Telavancin Uses, Side Effects & Warnings - Drugs.com

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# Telavancin

Generic name: telavancin [ TEL-a-VAN-sin ]
Brand name: Vibativ
Dosage form: intravenous powder for injection (750 mg)
Drug class: Glycopeptide antibiotics

Medically reviewed by Drugs.com on Feb 26, 2021. Written by Cerner Multum.

## What is telavancin?

Telavancin is an antibiotic that is used to treat severe skin infections caused by bacteria.

Telavancin is also used to treat pneumonia in a hospital setting, or pneumonia that can develop while using a ventilator (artificial breathing machine).

Telavancin may also be used for purposes not listed in this medication guide.

## Warnings

Certain people may be at greater risk of death from using televancin compared with another antibiotic called vancomycin, especially people with kidney problems who use telavancin for pneumonia that can develop while in a hospital.

Tell your doctor if you have a history of kidney problems. Your kidney function will need to be checked before, during and after treatment with telavancin.

You may not be able to use telavancin if you are pregnant. In animal studies, telavancin caused birth defects. You may need to have a negative pregnancy test before starting this treatment.

## Before taking this medicine

You should not use telavancin if you are allergic to telavancin, or if you are also using a certain type of heparin.

Certain people may be at greater risk of death from using televancin compared with another antibiotic called vancomycin. This risk has been highest in people with pre-existing kidney problems who use telavancin to treat pneumonia they had developed while in a hospital.

Tell your doctor if you have ever had:

- kidney problems;

- diabetes;

- heart disease, high blood pressure;

- long QT syndrome (in you or a family member);

- if you are allergic to vancomycin; or

- if you have routine "INR" or prothrombin time tests.

If you are able to become pregnant, you may need a pregnancy test before you start using telavancin. You are considered able to become pregnant unless you have ovarian failure, have had a tubal ligation or hysterectomy, or have been in menopause or not had a menstrual period in 2 years.

You may not be able to use this medicine if you are pregnant. In animal studies, telavancin caused birth defects. However, it is not known whether these effects would occur in humans. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of telavancin on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

## How is telavancin given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Telavancin is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Telavancin is usually given once every 24 hours for 7 to 21 days. This medicine must be given slowly, and the infusion can take at least 1 hour to complete. Follow your doctor's dosing instructions very carefully.

Telavancin must be mixed with a liquid (diluent) and then further diluted in an IV bag before using it. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine has particles in it. Call your pharmacist for new medicine.

Your kidney function will need to be checked before, during and after treatment with telavancin.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using telavancin.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Telavancin will not treat a viral infection such as the flu or a common cold.

Store unused vials in a refrigerator.

After mixing the diluent into a vial, you may keep the vial at room temperature for up to 12 hours before you further dilute the mixture in an IV bag and give the injection. If you store the vial in a refrigerator, you must further dilute and use it within 7 days.

The final mixed solution in the IV bag may also be kept frozen for up to 32 days at temperatures between 14 degrees and -22 degrees Fahrenheit (-10 degrees and -30 degrees Celsius).

Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

## What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

## What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

## What should I avoid while receiving telavancin?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

## Telavancin side effects

Some side effects may occur during the injection. Tell your caregiver if you feel itchy or tingly, or have a red rash during the injection.

Get emergency medical help if you have signs of an allergic reaction: hives; rapid heartbeats; difficult breathing, fainting; swelling of your face, lips, tongue, or throat.

Telavancin may cause serious side effects. Call your doctor at once if you have:

- severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);

- fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); or

- signs of kidney problems--little or no urinating, swelling in your ankles or feet, weight gain, or urine that looks foamy.

Common side effects of telavancin may include:

- foamy urine;

- nausea, vomiting;

- diarrhea; or

- changes in your sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Telavancin side effects (more detail)

## Telavancin dosing information

Usual Adult Dose for Skin and Structure Infection:

10 mg/kg by IV infusion over 60 minutes every 24 hours for 7 to 14 days
Comments:
-Therapy duration should be guided by the severity and site of the infection and the patient's clinical progress.
Use: Treatment of complicated skin and skin structure infections (cSSSI) caused by susceptible isolates of the following Gram-positive microorganisms: Staphylococcus aureus (including methicillin-susceptible and -resistant isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus anginosus group (includes S. anginosus, S. intermedius, S. constellatus), or Enterococcus faecalis (vancomycin-susceptible isolates only).

Usual Adult Dose for Nosocomial Pneumonia:

10 mg/kg by IV infusion over 60 minutes every 24 hours for 7 to 21 days
Comments:
-Therapy duration should be guided by the severity of the infection and the patient's clinical progress.
-This drug should be reserved for use when alternative treatments are not suitable.
Use: Treatment of hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) caused by susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and -resistant isolates).

Detailed Telavancin dosage information

## What other drugs will affect telavancin?

Telavancin can harm your kidneys or cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, HIV, osteoporosis, organ transplant rejection, bowel disorders, or pain or arthritis (including Advil, Motrin, and Aleve).

Tell your doctor about all your other medicines, especially:

- a diuretic or "water pill";

- heart rhythm medicine;

- a blood thinner--warfarin, Coumadin, Jantoven;

- certain heart or blood pressure medicine--benazepril, candesartan, captopril, enalapril, irbesartan, lisinopril, losartan, olmesartan, telmisartan, trandolapril, valsartan, and others; or

- NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may affect telavancin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Telavancin drug interactions (more detail)

## Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

## More about telavancin

- Check interactions
- Side effects
- Dosage information
- During pregnancy
- Drug class: glycopeptide antibiotics
- Breastfeeding
- En español

### Patient resources

- Advanced Reading

#### Other brands

Vibativ

### Professional resources

- Prescribing Information

### Related treatment guides

- Nosocomial Pneumonia
- Pneumonia
- Skin and Structure Infection

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 4.02.