Capsaicin and diclofenac topical Uses, Side Effects & Warnings - Drugs.com

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# Capsaicin and diclofenac (topical)

Generic name: capsaicin and diclofenac (topical) [ kap-SAY-i-sin-and-dye-KLOE-fen-ak-TOP-ik-al ]
Brand names: DermacinRx Lexitral PharmaPak, Diclotral Pak, Diclofex DC Therapy Pack, CapsFenac Pak, Dicloheal-60, Ziclocin
Dosage form: topical kit (0.025%-1.5%)
Drug class: Topical non-steroidal anti-inflammatories

Medically reviewed by Drugs.com on Jan 5, 2023. Written by Cerner Multum.

## What is capsaicin and diclofenac?

Capsaicin is the active ingredient in chili peppers that makes them hot. Capsaicin is used in medicated creams and lotions to relieve muscle or joint pain.

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID).

Capsaicin and diclofenac topical (for the skin) is a combination medicine used to treat joint pain, stiffness, and swelling caused by osteoarthritis of the knees. capsaicin and diclofenac may not be effective in treating arthritis pain elsewhere in the body.

Capsaicin and diclofenac may also be used for purposes not listed in this medication guide.

## Warnings

Diclofenac can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Diclofenac may also cause stomach or intestinal bleeding, which can be fatal.

## Before taking this medicine

Diclofenac can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use capsaicin and diclofenac just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Diclofenac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using capsaicin and diclofenac, especially in older adults.

You should not use this medicine if you are allergic to capsaicin or diclofenac, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Tell your doctor if you have ever had:

- heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;

- a heart attack, stroke, or blood clot;

- stomach ulcers or bleeding;

- asthma;

- liver or kidney disease; or

- fluid retention.

If you are pregnant, you should not use capsaicin and diclofenac unless your doctor tells you to. Using an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

This medicine is not approved for use by anyone younger than 18 years old.

## How should I use capsaicin and diclofenac?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not take by mouth. This medicine is for use only on the skin. If this medicine gets in your eyes, nose, or mouth, rinse with water.

Do not apply to open wounds or to sunburned, chapped, irritated, or infected skin. Do not cover treated skin with a bandage or expose it to heat from a hot tub, heating pad, or sauna.

Apply the solution only to clean, dry skin. Spread the solution over the front, back, and sides of the knee.

Wash your hands after applying this medicine. Wait at least 30 minutes before you bathe or shower.

Wait until the solution is completely dry before covering treated skin with clothing or applying any other skin products (cosmetics, sunscreen, lotions, insect repellant, or other medicated skin products).

Do not allow others to touch the area where you have applied the medicine.

Capsaicin can cause a burning sensation wherever it is applied. This sensation is usually mild and should gradually lessen over time with continued regular use of the medicine.

If the burning sensation is painful or causes significant discomfort, wash the treated skin area with soap and cool water. Get medical attention right away if you have severe burning, pain, swelling, or blistering.

If you use this medicine long-term, you may need frequent medical tests.

Call your doctor if your arthritis symptoms do not improve after 7 days of treatment, or if your symptoms get better and then worse within a few days.

Store at room temperature away from moisture and heat.

Capsaicin and diclofenac solution is flammable. Do not use near high heat or open flame. Do not smoke until the gel has completely dried on your skin.

## What happens if I miss a dose?

Since capsaicin and diclofenac is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

## What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222, especially if anyone has accidentally swallowed it.

## What should I avoid while using capsaicin and diclofenac?

Avoid exposing treated skin to heat, sunlight, or tanning beds.

Avoid taking a bath or shower within 30 minutes before or after you apply capsaicin and diclofenac to your skin. Also avoid vigorous exercise. Warm water or perspiration can increase the burning sensation caused by capsaicin.

Avoid getting this medicine in your eyes, nose, or mouth.

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to diclofenac (such as aspirin, ibuprofen, ketoprofen, or naproxen).

## Capsaicin and diclofenac side effects

Get emergency medical help if you have signs of an allergic reaction (sneezing, runny or stuffy nose, hives, wheezing or trouble breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Serious side effects are unlikely when capsaicin and diclofenac is applied to the skin, but can occur if the medicine is absorbed into your bloodstream.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

This medicine may cause serious side effects. Stop using this medicine and call your doctor at once if you have:

- a skin rash, no matter how mild;

- shortness of breath (even with mild exertion), swelling, rapid weight gain;

- signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

- liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

- kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or

- low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

Common side effects of capsaicin and diclofenac may include:

- skin rash, itching, redness, blistering, tingling, or other irritation where the medicine was applied; or

- dryness or hardening of treated skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Capsaicin / diclofenac topical side effects (more detail)

## What other drugs will affect capsaicin and diclofenac?

Tell your doctor about all your other medicines, especially:

- cyclosporine;

- lithium;

- methotrexate;

- a blood thinner (warfarin, Coumadin, Jantoven);

- heart or blood pressure medication, including a diuretic or "water pill"; or

- steroid medicine (prednisone and others).

This list is not complete. Other drugs may affect capsaicin and diclofenac, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Capsaicin / diclofenac topical drug interactions (more detail)

## Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

## More about capsaicin / diclofenac topical

- Check interactions
- Side effects
- Drug class: topical non-steroidal anti-inflammatories
- En español

### Patient resources

#### Other brands

DermacinRx Lexitral PharmaPak, Diclotral Pak

### Related treatment guides

- Pain

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 2.01.