Lokelma Uses, Side Effects & Warnings - Drugs.com

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# Lokelma

Generic name: sodium zirconium cyclosilicate [ SOE-dee-um-zir-KOE-nee-um-SYE-kloe-SIL-i-kate ]
Drug class: Cation exchange resins

Medically reviewed by Drugs.com on Sep 21, 2022. Written by Cerner Multum.

## What is Lokelma?

Lokelma is used to treat hyperkalemia (high levels of potassium in the blood) in adults.

Lokelma works directly in the intestines and is not absorbed into your bloodstream.

Lokelma may also be used for purposes not listed in this medication guide.

## Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

## Before taking this medicine

Tell your doctor if you have ever had:

- slow digestion;

- a bowel obstruction or severe constipation;

- heart problems; or

- if you are on a low-salt diet.

Because Lokelma is not absorbed into the bloodstream, it is not expected to be harmful during pregnancy or while nursing a baby. Tell your doctor if you are pregnant or breast-feeding.

## How should I take Lokelma?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

You will need medical tests to help your doctor determine how long to treat you with Lokelma.

Store at room temperature away from moisture and heat.

Lokelma can make it harder for your body to absorb other medicines you take by mouth. If you take any other medicines, take them 2 hours before or 2 hours after you take this medicine.

Detailed Lokelma dosage information

## What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

## What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

## What should I avoid while taking Lokelma?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

## Lokelma side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Lokelma contains sodium and may cause swelling or rapid weight gain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Lokelma side effects (more detail)

## What other drugs will affect Lokelma?

Other drugs may affect Lokelma, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Lokelma drug interactions (more detail)

## Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

## Popular FAQ

How does the drug Lokelma work?

Lokelma (sodium zirconium cyclosilicate) is an oral medicine that works by binding to potassium in the small and large intestines to help remove potassium from the blood. It binds to potassium and exchanges it for hydrogen and sodium. Lokelma is used to treat high potassium levels (hyperkalemia) in adults. Lokelma should not be used as an emergency treatment for life-threatening high potassium levels because it has a delayed onset of action. Continue reading

## More about Lokelma (sodium zirconium cyclosilicate)

- Check interactions
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- Drug images
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- FDA approval history
- Drug class: cation exchange resins
- Breastfeeding
- En español

### Patient resources

- Advanced Reading

### Professional resources

- Prescribing Information

### Related treatment guides

- Hyperkalemia

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 1.01.