Alka-Seltzer Plus Cold and Sinus Uses, Side Effects & Warnings - Drugs.com

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# Alka-Seltzer Plus Cold and Sinus

Generic name: acetaminophen and phenylephrine [ a-SEET-a-MIN-oh-fen-and-FEN-il-EFF-rin ]
Brand names: Alka-Seltzer Plus Cold and Sinus, Contac Cold+Flu Non-Drowsy, Excedrin Sinus Headache Caplet, Mapap Sinus Congestion and Pain, QlearQuil Daytime Sinus & Congestion, ... show all 11 brands Robitussin Nasal Relief, Sinus Congestion and Pain Daytime Cool Ice, Sinus Pain & Pressure, Sudafed PE Sinus Headache, Theraflu Daytime Severe Cold, Tylenol Sinus Congestion and Pain
Drug class: Upper respiratory combinations

Medically reviewed by Drugs.com on Aug 29, 2022. Written by Cerner Multum.

The Alka-Seltzer Plus Cold and Sinus brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.

## What is Alka-Seltzer Plus Cold and Sinus?

Acetaminophen is a pain reliever and a fever reducer.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Alka-Seltzer Plus Cold and Sinus is a combination medicine used to treat headache, fever, body aches, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu.

Alka-Seltzer Plus Cold and Sinus may also be used for purposes not listed in this medication guide.

## Warnings

Do not use Alka-Seltzer Plus Cold and Sinus if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).

In rare cases, acetaminophen may cause a severe skin reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

## Before taking this medicine

You should not use this medicine if you are allergic to acetaminophen (Tylenol) or phenylephrine.

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially:

- liver disease, cirrhosis, a history of alcoholism, or if you drink more than 3 alcoholic beverages per day;

- high blood pressure, heart disease, coronary artery disease;

- overactive thyroid;

- pheochromocytoma (an adrenal gland tumor); or

- if you take an anti-depressant.

It is not known whether Alka-Seltzer Plus Cold and Sinus will harm an unborn baby. Do not use cough or cold medicine without a doctor's advice if you are pregnant.

Acetaminophen and phenylephrine may pass into breast milk and may harm a nursing baby. Decongestants may also slow breast milk production. Do not use cough or cold medicine without a doctor's advice if you are pregnant.

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

## How should I take Alka-Seltzer Plus Cold and Sinus?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Dissolve one packet of the powder in at least 4 ounces of water. Stir this mixture and drink all of it right away.

Drop the effervescent tablets into a glass of water (at least 4 ounces, or one-half cup). Stir this mixture and drink all of it right away.

Stop taking the medicine and call your doctor if you still have a fever after 3 days of use, you still have pain after 7 days (or 5 days if treating a child), if your symptoms get worse, or if you have a skin rash, ongoing headache, or any redness or swelling.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken Alka-Seltzer Plus Cold and Sinus within the past few days.

Store at room temperature away from moisture and heat.

Detailed Alka-Seltzer Plus Cold and Sinus dosage information

## What happens if I miss a dose?

Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

## What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

## What should I avoid while taking Alka-Seltzer Plus Cold and Sinus?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

## Alka-Seltzer Plus Cold and Sinus side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking Alka-Seltzer Plus Cold and Sinus and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

The medicine may cause serious side effects. Stop using the medicine and call your doctor at once if you have:

- fast, slow, or uneven heart rate;

- confusion, hallucinations;

- tremor, seizure (convulsions);

- little or no urinating;

- nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

- dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, seizure).

Common side effects of Alka-Seltzer Plus Cold and Sinus may include:

- dizziness, weakness;

- mild headache;

- mild nausea, diarrhea, upset stomach;

- runny nose;

- feeling nervous, restless, or anxious; or

- sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Alka-Seltzer Plus Cold and Sinus side effects (more detail)

## What other drugs will affect Alka-Seltzer Plus Cold and Sinus?

Other drugs may interact with acetaminophen and phenylephrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Alka-Seltzer Plus Cold and Sinus drug interactions (more detail)

## Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

## More about Alka-Seltzer Plus Cold and Sinus (acetaminophen / phenylephrine)

- Check interactions
- Latest FDA alerts (3)
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations

### Patient resources

#### Other brands

Sudafed PE Sinus Pressure + Pain, Tylenol Sinus + Headache Day, Sinus Congestion and Pain Daytime Cool Ice, Vicks Sinex Daytime, ... +5 more

### Related treatment guides

- Nasal Congestion
- Sinus Symptoms

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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