Dyclonine Monograph for Professionals - Drugs.com

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# Dyclonine

Brand name: Sucrets
Drug class: Local Anesthetics
ATC class: R02AD04
VA class: DE700
CAS number: 536-43-6

Medically reviewed by Drugs.com on Jan 24, 2022. Written by ASHP.

## Introduction

Local anesthetic.

## Uses for Dyclonine

### Oral/Throat Analgesia/Anesthesia

Self-medication for the short-term relief of minor sore throat pain and mouth and gum irritation.

In fixed combination with menthol as self-medication for temporary relief of occasional minor irritation, pain, or soreness of mouth or throat, and for cough associated with a cold or inhaled irritants.

### Local Anesthesia

Has been used as a local anesthetic agent prior to laryngoscopy, bronchoscopy, esophagoscopy, or endotracheal intubation. However, oral solutions no longer are commercially available in the US.

## Dyclonine Dosage and Administration

### Administration

#### Oral Administration

Administer orally as a lozenge.

Allow the lozenge to slowly dissolve in the mouth; do not bite or chew it.

### Dosage

#### Pediatric Patients

##### Oral/Throat Pain

###### Oral

Children ≥2 years of age: 1 lozenge (1.2, 2, or 3 mg); repeat after 2 hours if necessary.

#### Adults

##### Oral/Throat Pain

###### Oral

1 lozenge (1.2, 2, or 3 mg); repeat after 2 hours if necessary.

### Prescribing Limits

#### Pediatric Patients

##### Oral/Throat Pain

###### Oral

Children ≥2 years of age: Maximum 10 lozenges daily. Not for self-medication of sore throat for >2 days or sore mouth >7 days.

#### Adults

##### Oral/Throat Pain

###### Oral

Maximum 10 lozenges daily. Not for self-medication of sore throat for >2 days or sore mouth >7 days.

### Special Populations

No special population dosage recommendations at this time.

Detailed Dyclonine topical dosage information

## Related/similar drugs

Buprenex, aspirin, acetaminophen, tramadol, Tylenol, naproxen, oxycodone

## Cautions for Dyclonine

### Contraindications

- Known hypersensitivity to dyclonine or any ingredient in the formulation.

### Warnings/Precautions

#### Sensitivity Reactions

##### Allergic Reactions

Use with caution in patients with a known allergy to dyclonine.

Sensitization and allergic reactions are infrequent. Possible hypersensitivity reactions to anesthetics may manifest as cutaneous lesions with delayed onset, urticaria, swelling, and edema.

#### General Precautions

##### Systemic Effects

Systemic (e.g., CNS, cardiovascular) effects possible with excessive dosage or rapid absorption of dyclonine.

Adverse CNS effects may include excitation and/or depression, nervousness, dizziness, blurred vision, or tremors followed by seizures, unconsciousness, drowsiness, and possibly respiratory arrest.

Adverse cardiovascular effects may include myocardial depression, hypotension, bradycardia, and cardiac arrest.

##### Patient Monitoring

If sore throat is severe or persistent (e.g., >2 days) or occurs with or is followed by a high fever, persistent headache, rash, swelling, irritation, and nausea, discontinue the drug and consult a clinician.

If sore mouth symptoms do not improve after 7 days, discontinue the drug and consult a clinician.

##### Infection or Trauma

Use with extreme caution in areas with traumatized mucosa and/or when sepsis is present in the region of intended application.

##### Use of Fixed Combination

When used in fixed combination with other agents, consider the cautions, precautions, and contraindications associated with the concomitant agents.

#### Specific Populations

##### Pregnancy

Safety has not been established in pregnant women. Manufacturers state that pregnant women should consult a clinician prior to use.

##### Lactation

Manufacturers state that nursing women should consult a clinician prior to use.

##### Pediatric Use

Safety of dyclonine lozenges not established in children <2 years of age; consult a clinician or dentist prior to use in such patients.

### Common Adverse Effects

Irritation, stinging.

## Dyclonine Pharmacokinetics

### Absorption

#### Onset

Following topical application of a 0.5 or 1% solution of dyclonine (both no longer commercially available in the US) to mucous membranes, local anesthesia occurs within 2–10 minutes.

#### Duration

Following topical application of a 0.5 or 1% solution of dyclonine, anesthesia persists for approximately 30 minutes.

## Stability

### Storage

#### Oral

##### Lozenges

Protect from excessive heat (temperatures >38°C).

## Actions

- Local anesthetic and analgesic.

## Advice to Patients

- Advise patients to suck rather than chew or bite the lozenge.

- Advise patients to consult a clinician prior to use for a chronic cough secondary to smoking, asthma, or emphysema or a cough accompanied by excessive phlegm.

- Advise patients to discontinue the drug and consult a clinician if sore throat symptoms or cough do not improve after 2 days or if sore mouth symptoms do not improve after 7 days.

- If irritation, pain, or hypersensitivity occurs, discontinue use and consult a clinician or dentist.

- Importance of informing clinician of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.

- Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.

- Importance of informing patients of other important precautionary information. (See Cautions.)

## Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Dyclonine Hydrochloride
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer
--- | --- | --- | --- | ---
Oral | Lozenges | 1.2 mg* | Sucrets Children’s | Insight
|  | 2 mg* | Sucrets Regular Strength | Insight
|  | 3 mg* | Sucrets Maximum Strength | Insight

Dyclonine Hydrochloride Combinations
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer
--- | --- | --- | --- | ---
Oral | Lozenges | 3 mg with Menthol 6 mg | Sucrets Complete | Insight

AHFS DI Essentials™. © Copyright 2023, Selected Revisions February 1, 2008. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

Reload page with references included

## More about dyclonine topical

- Reviews (3)
- Side effects
- Dosage information
- Drug class: mouth and throat products
- Breastfeeding

### Patient resources

- Patient Information

### Professional resources

#### Other brands

Dyclopro

### Related treatment guides

- Pain
- Sore Throat

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