Pasque Flower Uses, Benefits & Dosage - Drugs.com Herbal Database

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# Pasque Flower

Scientific Name(s): Pulsatilla patens (L.) Mill., Pulsatilla pratensis L., Pulsatilla vulgaris Mill.
Common Name(s): Easter flower, Meadow anemone, Pasque flower, Pulsatilla, Wind flower

Medically reviewed by Drugs.com. Last updated on Aug 16, 2022.

## Clinical Overview

### Use

Pasque flower has confirmed antibiotic and uterotonic activity; however, it is not recommended for human use.

### Dosing

There is no recent evidence to support specific doses of pasque flower. The fresh plant is toxic; classical doses of the dried herb were from 0.1 to 0.4 g daily.

### Contraindications

No longer considered safe.

### Pregnancy/Lactation

Documented adverse effects. Avoid use. Uterine stimulant.

### Interactions

None well documented.

### Adverse Reactions

No data.

### Toxicology

Pasque flower is extremely toxic and should not be ingested or applied to the skin.

## Scientific Family

- Ranunculaceae (buttercup)

## Botany

Several closely related species of pulsatilla have found medicinal use in Europe and North America. They are perennial herbs that grow in well-drained, sandy or rocky soil, blooming early in spring soon after snow has melted. The single large flower is characterized by the large, colored bracts, which have the appearance of petals. The whole plant is covered with silky hairs that give the ripe fruit the appearance of a mop head. All parts of the fresh plant have an acrid taste. Molecular research has defined the relationships between different species of pulsatilla and related genera, and has suggested that the genera Pulsatilla, Hepatica, and Knowltonia should be merged into the single genus Anemone.Hoot 1994

## History

The dried whole plant of pulsatilla has been used in Europe for a variety of medicinal purposes, including dysmenorrhea and other gynecological disorders, skin diseases, asthma, and eye infections, and as a diuretic and expectorant.Grieve 1931 It is widely used in homeopathic preparations, once being considered specific for measles, and also used for toothache, earache, and indigestion. A large number of Asian species of pulsatilla (eg, Pulsatilla cernua. Spreng, Japanese name "Hakutoo," Pulsatilla chinensis (Bunge) Regel. and others, Chinese name "Bai Tou Weng") have also been used medicinally.Shimizu 1978, Ye 1999

## Chemistry

The most notable compounds in pulsatilla and many other Ranunculaceae are ranunculin, protoanemonin, and anemonin. Ranunculin is a glycoside that is enzymatically hydrolyzed when the tissues are crushed to the volatile unsaturated lactone protoanemonin, which then dimerizes to anemonin on exposure to air. Protoanemonin is extremely volatile and vesicant. Anemonin was first isolated in 1792Heyer 1792 and protoanemonin was elucidated in 1920.Asahina 1920 Ranunculin was characterized in 1951, and the gross structure of anemonin was proposed.Hill 1951 The complete stereostructure of anemonin was determined by x-ray crystallography in 1965.Moriarty 1965

Triterpene saponins are found in various species of pulsatillaLi 1990, Shimizu 1978, Ye 1995, Ye 1996, Ye 1998, Ye 1999 while flavonoids also have been isolated.Yoshitama 1998 A novel bicyclic quinone was recently reported from P. koreana.Moon 2000

## Uses and Pharmacology

Protoanemonin has been reported to have antibacterialBaer 1946, Carlson 1946, Holden 1974, Seegal 1945 antimalarialCarlson 1946 and antifungalMartin 1990, Misra 1980 activity, and has been found to be cytotoxic as well.Campbell 1979 These properties may be due to the ability of protoanemonin to alkylate reactive moieties on proteins and other biomolecules.

The saponins of pulsatilla species have been reported to have cytotoxicMimaki 1999 antifungal, molluscicidalEkabo 1996 and sucrase inhibitory properties.Zhang 2000 The lignan beta-peltatin, isolated from P. chinensis, was strongly cytotoxic.Mimaki 1999 Antibacterial properties were reported for pulsaquinone, the quinone isolated from P. koreana.Moon 2000

### Animal data

In animals, protoanemonin and anemonin have a sedating effect, while anemonin was antipyreticMartin 1988 effects also seen in screening of the extract of P. alpina.Martin 1987 A uterotonic effect of the extract has also been documented.Farnsworth 1975

Paradoxically, protoanemonin is antimutagenic in the Ames test.Minakata 1983 Sheep and other animals have been killed by overgrazing on protoanemonin-containing plants, and abortions and teratogenic effects have been observed.American Botanical Council 1998

## Dosing

There is no recent evidence to support specific doses of pasque flower. The fresh plant is toxic; classical doses of the dried herb were from 0.1 to 0.4 g daily.

## Pregnancy / Lactation

Documented adverse effects. Avoid use. Uterine stimulant.Brinker 1998, Ernst 2002 A uterotonic effect of the extract has also been documented.Farnsworth 1975

Pulsatilla was identified as the most common herb used for malpresentation/breech labor induction by certified or licensed midwives in state-wide surveys conducted in California, Texas, and North Carolina.Dennehy 2010

## Interactions

None well documented.

## Adverse Reactions

Blistering of the skin is due to protoanemonin, which, since it is volatile and reactive, both evaporates or is converted to anemonin on drying of the plant.Hill 1951

## Toxicology

Fresh plant material of pasque flower is extremely toxic and should not be ingested or applied to the skin. Paradoxically, protoanemonin is antimutagenic in the Ames test.Minakata 1983 Sheep and other animals have been killed by overgrazing on protoanemonin-containing plants, and abortions and teratogenic effects have been observed.American Botanical Council 1998

## Index Terms

- Anemone
- Hepatica
- Knowltonia

## References

## Disclaimer

This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.

This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.

Asahina Y, et al. J Pharm Soc Jpn. 1920;455:1.
Baer H, et al. The nature of antibacterial agent from Anemone pulsatilla. J Biol Chem. 1946;162:65-68.
Brinker FJ. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications; 1998.
Campbell W, et al. Anemonin, protoanemonin, and ranunculin from Knowltonia capensis. Phytochemistry. 1979;18:323-324.216833
Carlson H, et al. Antimalarial and antibacterial substances separated from higher plants. J Bacteriol. 1946;52:155-168.16561159
Dennehy C, Tsourounis C, Bui L, King TL. The use of herbs by California midwives. J Obstet Gynecol Neonatal Nurs. 2010;39(6):684-693.21044150
Ekabo O, et al. Antifungal and molluscicidal saponins from Serjania salzmanniana. J Nat Prod. 1996;59:431-435.8699187
Ernst E. Herbal medicinal products during pregnancy: are they safe? BJOG. 2002;109:227-235.11950176
Farnsworth N, et al. Potential value of plants as sources of new antifertility agents. I. J Pharm Sci 1975;64:535.167146
Grieve M. A Modern Herbal. London, England: Jonathan Cape, Ltd.,1931:32-33.
Heyer M. Chemisch J V Crell. 1792;2:102.
Hill R, et al. Ranunculin: The precursor of the vesicant substance of the buttercup. Biochem J. 1951;49:332-335.14858339
Holden M, et al. The range of antibiotic activity of protoanemonin. Proc Soc Exp Biol Med. 1974;66:54-60.
Hoot S, et al. Structural rearrangements, including parallel inversions, within the chloroplast genome of Anemone and related genera. J Mol Evol. 1994;38:274-81.8006994
Li X, et al. Triterpenoid saponins from Pulsatilla campanella. Phytochemistry. 1990;29:595-599.
Martin M, et al. In vitro activity of protoanemonin, an antifungal agent. Planta Med. 1990;56:66-69.2356244
Martin M, et al. Pharmacologic effects of lactones isolated from Pulsatilla alpina subsp. apiifolia. J Ethnopharmacol. 1988;24:185-191.
Martin M, et al. Pharmacological screening of Pulsatilla alpina subsp. apiifolia. J Ethnopharmacol. 1987;21:201-206.3437772
Mimaki Y, et al. Triterpene saponins and lignans from the roots of Pulsatilla chinensis and their cytotoxic activity against HL-60 cells. J Nat Prod. 1999;62:1279-1283.10514313
Minakata H, et al. Protoanemonin, an antimutagen isolated from plants. Mutat Res. 1983;116:317-322.6339898
Misra S, et al. Antifungal principle of Ranunculus scleratus. Econ Bot. 1980;34:362-367.
Moon J, et al. Isolation and structural determination of a novel antimicrobial compound from the roots of Pulsatilla koreana. Nat Prod Lett. 2000;14(4):311-317.
Moriarty R, et al. The structure of anemonin. J Am Chem Soc. 1965;87:3251-3252.
Seegal B, et al. The antibiotic activity of extracts of Ranunculaceae. Science. 1945;101:413-414.17758732
Shimizu M, et al. Triterpenoid saponins from Pulsatilla cernua Spreng. I. Chem Pharm Bull. 1978;26:1666-1671.
The Complete German Commission E Monographs–Therapeutic Guide to Herbal Medicines. Austin, TX: American Botanical Council, 1998:363.
Ye W, et al. Five new triterpene saponins from Pulsatilla patens var. multifida. J Nat Prod. 1999;62:233-237.10075748
Ye W, et al. Patensin, a saponin from Pulsatilla patens var. multifida. Phytochemistry. 1995;39:937-939.7626268
Ye W, et al. Pulsatilloside C from the roots of Pulsatilla chinensis. J Nat Prod. 1998;61:658-659.9599271
Ye W, et al. Triterpenoids from Pulsatilla chinensis. Phytochemistry. 1996;42:799-802.
Yoshitama K, et al. An acylated pelargonin diglycoside from Pulsatilla cernua. Phytochemistry. 1998;47:105-107.
Zhang Q, et al. Cernuosides A and B, two sucrase inhibitors from Pulsatilla cernua. J Nat Prod. 2000;63:276-278.

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