Cytarabine liposome Intrathecal Advanced Patient Information - Drugs.com

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# Cytarabine liposome (Intrathecal)

Medically reviewed by Drugs.com. Last updated on Jun 28, 2022.

Intrathecal route(Suspension)

Chemical arachnoiditis, a syndrome manifested primarily by nausea, vomiting, headache, and fever, was a common adverse event in all clinical studies. Chemical arachnoiditis may be fatal if left untreated. Patients receiving cytarabine liposome should receive dexamethasone concurrently to mitigate the symptoms of chemical arachnoiditis .

## Commonly used brand name(s)

In the U.S.

- Depocyt

Pharmacologic Class: Antimetabolite

## Uses for cytarabine liposome

Liposomal cytarabine belongs to the group of medicines known as antineoplastics. It is used to treat cancer of the lymph system that has spread to the brain.

Liposomal cytarabine interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Some of these may be serious and must be reported to your doctor. Some effects may occur after treatment with liposomal cytarabine has been stopped.

Before you begin treatment with liposomal cytarabine, you and your doctor should talk about the good cytarabine liposome will do as well as the risks of using it.

Liposomal cytarabine is to be administered only by or under the immediate supervision of your doctor.

## Before using cytarabine liposome

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For cytarabine liposome, the following should be considered:

### Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to cytarabine liposome or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

### Pediatric

Studies on cytarabine liposome have been done only in adult patients, and there is no specific information comparing use of liposomal cytarabine in children with use in other age groups.

### Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of liposomal cytarabine in the elderly with use in other age groups.

### Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

### Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking cytarabine liposome, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using cytarabine liposome with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

- Measles Virus Vaccine, Live
- Mumps Virus Vaccine, Live
- Rotavirus Vaccine, Live
- Rubella Virus Vaccine, Live
- Varicella Virus Vaccine, Live
- Zoster Vaccine, Live

Using cytarabine liposome with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

- Adenovirus Vaccine
- Bacillus of Calmette and Guerin Vaccine, Live
- Cedazuridine
- Cholera Vaccine, Live
- Dengue Tetravalent Vaccine, Live
- Influenza Virus Vaccine, Live
- Poliovirus Vaccine, Live
- Smallpox Vaccine
- Typhoid Vaccine, Live
- Yellow Fever Vaccine

### Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

### Other medical problems

The presence of other medical problems may affect the use of cytarabine liposome. Make sure you tell your doctor if you have any other medical problems, especially:

- Active meningitis—Use is not recommended

- Blockage to cerebrospinal fluid flow— Increased risk of neurotoxicity

## Proper use of cytarabine liposome

Cytarabine liposome often causes nausea and vomiting. However, it is very important that you continue to receive the medicine, even if you begin to feel ill. Ask your health care professional for ways to lessen these effects.

### Dosing

The dose of cytarabine liposome will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of cytarabine liposome. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Detailed Cytarabine liposomal dosage information

## Precautions while using cytarabine liposome

It is very important that your doctor check your progress at regular visits to make sure that cytarabine liposome is working properly and to check for unwanted effects.

## Cytarabine liposome side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

- Back pain
- fever
- headache
- nausea
- neck pain or rigidity
- sleepiness
- vomiting
- weakness

Less common

- Black, tarry stools
- blood in urine or stools
- chills
- cough or hoarseness
- lower back or side pain
- painful or difficult urination
- pinpoint red spots on skin
- sore throat
- swelling of fingers, hands, arms, lower legs, or feet
- unusual bleeding or bruising

Rare

- Fast or irregular breathing
- puffiness or swelling around the face
- shortness of breath
- sudden, severe decrease in blood pressure
- unusual tiredness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

- Constipation
- urinary incontinence

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Cytarabine liposomal side effects (more detail)

## More about cytarabine liposomal

- Check interactions
- Side effects
- Dosage information
- During pregnancy
- Drug class: antimetabolites

### Patient resources

- Patient Information

#### Other brands

DepoCyt

### Related treatment guides

- Meningitis, Lymphomatous

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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