Dostarlimab-gxly Intravenous Advanced Patient Information - Drugs.com

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# Dostarlimab-gxly (Intravenous)

Medically reviewed by Drugs.com. Last updated on Nov 11, 2022.

## Commonly used brand name(s)

In the U.S.

- Jemperli

Available Dosage Forms:

- Solution

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Dostarlimab

## Uses for dostarlimab-gxly

Dostarlimab-gxly injection is used to treat endometrial cancer (cancer of the lining of the uterus or womb) that is mismatch repair deficient (dMMR) in patients whose cancer has returned, or it has spread or cannot be removed by surgery. It is given to patients who have received other cancer medicines (eg, platinum) that did not work well. Your doctor will perform a test to check for the dMMR tumor before you use dostarlimab-gxly.

Dostarlimab-gxly is a monoclonal antibody that changes the immune system to help control the growth of cancer cells.

Dostarlimab-gxly is to be given only by or under the direct supervision of your doctor.

## Before using dostarlimab-gxly

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dostarlimab-gxly, the following should be considered:

### Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to dostarlimab-gxly or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

### Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of dostarlimab-gxly injection in the pediatric population. Safety and efficacy have not been established.

### Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dostarlimab-gxly injection in the elderly.

### Breastfeeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using dostarlimab-gxly.

### Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

### Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

### Other medical problems

The presence of other medical problems may affect the use of dostarlimab-gxly. Make sure you tell your doctor if you have any other medical problems, especially:

- Colitis (inflammation of the bowels) or
- Diabetic ketoacidosis or
- Hepatitis (inflammation of the liver) or
- Hyperthyroidism (high levels of thyroid hormone) or
- Hypophysitis (inflammation of the pituitary gland) or
- Hypothyroidism (low levels of thyroid hormone) or
- Immune system problems or
- Nephritis (inflammation of the kidneys) or
- Pneumonitis (inflammation of the lungs) or
- Type 1 diabetes—Use with caution. May make these conditions worse.

- Organ transplant (eg, kidney or liver transplant), recent—Use with caution. May increase risk for organ transplant rejection.

- Patients who have had allogeneic hematopoietic stem cell transplant (HSCT)—Use with caution. May cause side effects to become worse.

## Related/similar drugs

methotrexate, Keytruda, hydroxyurea, pembrolizumab, medroxyprogesterone, megestrol, Provera

## Proper use of dostarlimab-gxly

A nurse or other trained health professional will give you dostarlimab-gxly. It is given through a needle placed into one of your veins. It must be given slowly, so the needle will have to remain in place for at least 30 minutes. The infusion will be given every 3 or 6 weeks, depending on your dose.

Dostarlimab-gxly comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

### Missed dose

Dostarlimab-gxly needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Detailed Dostarlimab dosage information

## Precautions while using dostarlimab-gxly

It is very important that your doctor check your progress at regular visits to make sure that dostarlimab-gxly is working properly. Blood and urine tests may be needed to check for unwanted effects.

Receiving dostarlimab-gxly while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using dostarlimab-gxly to make sure you are not pregnant. Use an effective form of birth control to keep from getting pregnant during treatment with dostarlimab-gxly and for at least 4 months after the last dose. If you think you have become pregnant while receiving the medicine, tell your doctor right away.

Tell your doctor right away if you have a cough, chest tightness, or any type of breathing problem with dostarlimab-gxly. These could be symptoms of a serious lung problem.

Colitis (swelling of the colon or bowel) may occur with dostarlimab-gxly. Tell your doctor right away if you have stomach pain or tenderness, watery or bloody diarrhea, or a fever after receiving the medicine.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Serious problems with the adrenal, pituitary, or thyroid glands (hormone glands) may occur while you are receiving dostarlimab-gxly. Tell your doctor if you start having continuing or unusual headaches, changes in mood or behavior (eg, being irritable or forgetful), lightheadedness, dizziness, or fainting, unusual sluggishness, or an increase in weight.

Dostarlimab-gxly may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

Dostarlimab-gxly may cause serious kidney problems (eg, nephritis, kidney failure). Tell your doctor right away if you have bloody or cloudy urine, nausea, vomiting, trouble breathing, swelling of the face, feet, or lower legs, unusual tiredness or weakness, or unusual weight gain.

Tell your doctor right away if you have changes in your eyesight, severe or persistent muscle or joint pain, or severe muscle weakness after receiving dostarlimab-gxly.

Dostarlimab-gxly may increase your risk for possible organ transplant rejection. Talk to your doctor about this risk.

Serious skin reactions (eg, exfoliative dermatitis, Stevens-Johnson syndrome, drug rash with eosinophilia and systemic syndrome (DRESS), and toxic epidermal necrolysis) can occur with dostarlimab-gxly. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, chills, cough, diarrhea, itching, joint or muscle pain, red irritated eyes, red skin lesions, often with a purple center, severe acne or skin rash, sores or ulcers on the skin, mouth or lips, or swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness with dostarlimab-gxly.

Dostarlimab-gxly may cause infusion-related reactions. These can be life-threatening and require immediate medical attention. Tell your doctor right away if you start to have a fever, chills or shaking, dizziness, trouble breathing, itching or rash, lightheadedness or fainting after receiving dostarlimab-gxly.

## Dostarlimab-gxly side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

- Bladder pain
- bloody or cloudy urine
- constipation
- depression
- difficult, burning, or painful urination
- dry skin and hair
- feeling cold
- frequent urge to urinate
- hair loss
- hoarseness or husky voice
- loss of appetite
- lower back or side pain
- muscle cramps and stiffness
- pale skin
- slow heartbeat
- sore tongue
- trouble breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
- weight gain

Less common

- Agitation
- chest pain or tightness
- chills
- coma
- confusion
- cough
- cough producing mucus
- decreased urine output
- diarrhea
- dizziness
- fever
- general feeling of discomfort or illness
- headache
- hostility
- irritability
- lethargy
- muscle twitching
- nausea
- nervousness
- rapid weight gain
- seizures
- sensitivity to heat
- stomach cramps, tenderness, or pain
- stupor
- sweating
- swelling of the face, feet, lower legs, ankles, or hands
- thickening of bronchial secretions
- trouble sleeping
- watery or bloody diarrhea
- weight loss

Rare

- Anxiety
- back or leg pain
- black, tarry stools
- bleeding gums
- bloating
- blood in the stools
- blue or pale skin
- blurred vision
- burning, tingling, numbness, or pain in the hands, arms, feet, or legs
- burning feeling in the chest or stomach
- change in vision
- chest pain, possibly moving to the left arm, neck, or shoulder
- dark urine
- darkening of the skin
- drowsiness
- dry mouth
- eye pain
- fainting
- fast heartbeat
- general body swelling
- inability to move the arms and legs
- indigestion
- joint pain
- light-colored stools
- lightheadedness
- loss of consciousness
- loss of strength or energy
- muscle aches, pain, tenderness, or weakness
- nosebleeds
- numbness or tingling in the fingers, face, or feet
- pains in the stomach, side, or abdomen, possibly radiating to the back
- partial or slight paralysis
- pinpoint red spots on the skin
- rapid, shallow breathing
- redness of the eye
- sensation of pins and needles
- sensitivity of the eye to light
- severe headache
- skin rash, redness, soreness, or itching
- sores, welting, or blisters
- stabbing pain
- stiff neck or back
- stomach discomfort or upset
- sudden numbness and weakness in the arms and legs
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- tearing
- upper right abdominal or stomach pain
- vomiting
- yellow eyes and skin

Incidence not known

- Blistering, peeling, or loosening of the skin
- cracks in the skin
- flushed, dry skin
- fruit-like breath odor
- increased hunger
- increased thirst
- increased urination
- loss of heat from the body
- red irritated eyes
- red skin lesions, often with a purple center
- red, swollen skin
- scaly skin
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

- Constipation

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Dostarlimab side effects (more detail)

## More about dostarlimab

- Check interactions
- Side effects
- Dosage information
- During pregnancy
- Drug class: anti-PD-1 monoclonal antibodies
- Breastfeeding
- En español

### Patient resources

- Drug Information

#### Other brands

Jemperli

### Professional resources

- Prescribing Information

### Related treatment guides

- Endometrial Cancer
- Solid Tumors

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer