Orphenadrine, aspirin, and caffeine Advanced Patient Information - Drugs.com

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# Orphenadrine, aspirin, and caffeine (Oral)

Medically reviewed by Drugs.com. Last updated on Oct 6, 2022.

## Commonly used brand name(s)

In the U.S.

- Norgesic
- Norgesic Forte
- Orphenadrine w/A.C.
- Orphengesic
- Orphengesic Forte

Available Dosage Forms:

- Tablet

Therapeutic Class: Skeletal Muscle Relaxant, Centrally Acting/Salicylate, Aspirin Combination

Pharmacologic Class: Orphenadrine

Chemical Class: Salicylate, Aspirin

## Uses for orphenadrine, aspirin, and caffeine

Orphenadrine, aspirin, and caffeine combination is used to relieve mild to moderate pain in patients with acute (short-term) muscle or bone problems. It helps relax certain muscles in your body, which relieves the pain and discomfort caused by strains, sprains, or other injury to your muscles. However, orphenadrine, aspirin, and caffeine does not take the place of rest, exercise, or other treatment that your doctor may recommend for your medical problem.

Orphenadrine acts in the central nervous system (CNS) to produce its muscle relaxant effects. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and reduce fever. Caffeine is a CNS stimulant that is used together with pain relievers to increase their effect.

Orphenadrine, aspirin, and caffeine is available only with your doctor's prescription.

## Before using orphenadrine, aspirin, and caffeine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For orphenadrine, aspirin, and caffeine, the following should be considered:

### Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to orphenadrine, aspirin, and caffeine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

### Pediatric

Because of aspirin's toxicity, use in children younger than 12 years of age is not recommended. Do not give aspirin to a child who has chickenpox or flu symptoms, unless approved by a doctor.

### Geriatric

No information is available on the relationship of age to the effects of orphenadrine, aspirin, and caffeine combination in geriatric patients.

### Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

### Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking orphenadrine, aspirin, and caffeine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using orphenadrine, aspirin, and caffeine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

- Abrocitinib
- Defibrotide
- Dichlorphenamide
- Influenza Virus Vaccine, Live
- Ketorolac
- Potassium Citrate
- Riociguat
- Viloxazine

Using orphenadrine, aspirin, and caffeine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

- Acarbose
- Aceclofenac
- Acemetacin
- Acenocoumarol
- Acetazolamide
- Alfentanil
- Alipogene Tiparvovec
- Alprazolam
- Alteplase, Recombinant
- Amifampridine
- Amiloride
- Amineptine
- Amitriptyline
- Amitriptylinoxide
- Amoxapine
- Amtolmetin Guacil
- Anagrelide
- Anisindione
- Apixaban
- Ardeparin
- Argatroban
- Bemiparin
- Bendroflumethiazide
- Benzhydrocodone
- Benzthiazide
- Betrixaban
- Bivalirudin
- Bromazepam
- Bromfenac
- Bufexamac
- Bumetanide
- Buprenorphine
- Butorphanol
- Calcium Oxybate
- Cannabidiol
- Caplacizumab-yhdp
- Capmatinib
- Celecoxib
- Certoparin
- Cetirizine
- Chlorothiazide
- Chlorpropamide
- Chlorthalidone
- Choline Salicylate
- Cilostazol
- Citalopram
- Clobazam
- Clomipramine
- Clonazepam
- Clonixin
- Clopamide
- Clopidogrel
- Clozapine
- Codeine
- Cyclopenthiazide
- Cyclosporine
- Dabigatran Etexilate
- Dalteparin
- Danaparoid
- Daridorexant
- Desipramine
- Desirudin
- Desmopressin
- Desvenlafaxine
- Dexibuprofen
- Dexketoprofen
- Dexmedetomidine
- Diazoxide
- Dibenzepin
- Diclofenac
- Dicumarol
- Diflunisal
- Digoxin
- Dihydrocodeine
- Dipyrone
- Donepezil
- Dothiepin
- Doxepin
- Doxylamine
- Droxicam
- Duloxetine
- Edoxaban
- Enoxaparin
- Eplerenone
- Eptifibatide
- Escitalopram
- Esketamine
- Ethacrynic Acid
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Fenoprofen
- Fentanyl
- Fepradinol
- Feprazone
- Feverfew
- Flibanserin
- Floctafenine
- Flufenamic Acid
- Fluoxetine
- Flurbiprofen
- Fluvoxamine
- Fondaparinux
- Furosemide
- Gabapentin
- Gabapentin Enacarbil
- Ginkgo
- Givosiran
- Glimepiride
- Glipizide
- Glucagon
- Glyburide
- Glycopyrrolate
- Glycopyrronium Tosylate
- Gossypol
- Heparin
- Hydrochlorothiazide
- Hydrocodone
- Hydroflumethiazide
- Hydromorphone
- Ibrutinib
- Ibuprofen
- Imipramine
- Indapamide
- Indomethacin
- Inotersen
- Iobenguane I 131
- Ketamine
- Ketoprofen
- Lemborexant
- Lepirudin
- Levocetirizine
- Levomilnacipran
- Levorphanol
- Lithium
- Lofepramine
- Lofexidine
- Lornoxicam
- Loxapine
- Loxoprofen
- Lumiracoxib
- Macimorelin
- Magnesium Oxybate
- Meclofenamate
- Mefenamic Acid
- Melitracen
- Meloxicam
- Meperidine
- Metformin
- Methacholine
- Methadone
- Methotrexate
- Methyclothiazide
- Metoclopramide
- Metolazone
- Midazolam
- Milnacipran
- Morniflumate
- Morphine
- Morphine Sulfate Liposome
- Nabumetone
- Nadroparin
- Nalbuphine
- Naproxen
- Nateglinide
- Nefazodone
- Nepafenac
- Nicorandil
- Niflumic Acid
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Nortriptyline
- Opipramol
- Oxaprozin
- Oxycodone
- Oxymorphone
- Oxyphenbutazone
- Parecoxib
- Parnaparin
- Paroxetine
- Peginterferon Alfa-2b
- Pemetrexed
- Pentazocine
- Pentosan Polysulfate Sodium
- Pentoxifylline
- Phenindione
- Phenprocoumon
- Phenylbutazone
- Piketoprofen
- Piracetam
- Piroxicam
- Pixantrone
- Polythiazide
- Potassium Citrate
- Potassium Oxybate
- Pranoprofen
- Prasugrel
- Pregabalin
- Proglumetacin
- Propyphenazone
- Proquazone
- Protein C
- Protriptyline
- Quetiapine
- Remifentanil
- Remimazolam
- Repaglinide
- Reteplase, Recombinant
- Revefenacin
- Reviparin
- Rivaroxaban
- Rofecoxib
- Ropeginterferon Alfa-2b-njft
- Salicylic Acid
- Salsalate
- Scopolamine
- Secretin Human
- Selumetinib
- Sertraline
- Sodium Oxybate
- Sodium Salicylate
- Spironolactone
- Sufentanil
- Sulindac
- Sulodexide
- Tacrolimus
- Tapentadol
- Tenofovir Disoproxil Fumarate
- Tenoxicam
- Tianeptine
- Tiaprofenic Acid
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tiotropium
- Tirofiban
- Tolazamide
- Tolbutamide
- Tolfenamic Acid
- Tolmetin
- Torsemide
- Tramadol
- Trazodone
- Treprostinil
- Triamterene
- Trichlormethiazide
- Trimipramine
- Valdecoxib
- Varicella Virus Vaccine, Live
- Venlafaxine
- Vilazodone
- Vortioxetine
- Warfarin
- Xipamide
- Zolpidem

Using orphenadrine, aspirin, and caffeine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

- Acebutolol
- Atenolol
- Betamethasone
- Betaxolol
- Bisoprolol
- Captopril
- Carteolol
- Carvedilol
- Celiprolol
- Cortisone
- Delapril
- Dexamethasone
- Enalaprilat
- Enalapril Maleate
- Esmolol
- Imidapril
- Labetalol
- Levobunolol
- Lisinopril
- Methylprednisolone
- Metipranolol
- Metoprolol
- Nadolol
- Nebivolol
- Nitroglycerin
- Oxprenolol
- Paramethasone
- Penbutolol
- Perphenazine
- Pindolol
- Practolol
- Prednisolone
- Prednisone
- Probenecid
- Propranolol
- Sotalol
- Streptokinase
- Tamarind
- Temocapril
- Tenecteplase
- Timolol
- Triamcinolone
- Valproic Acid

### Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using orphenadrine, aspirin, and caffeine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use orphenadrine, aspirin, and caffeine, or give you special instructions about the use of food, alcohol, or tobacco.

- Tobacco

Using orphenadrine, aspirin, and caffeine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use orphenadrine, aspirin, and caffeine, or give you special instructions about the use of food, alcohol, or tobacco.

- Ethanol

### Other medical problems

The presence of other medical problems may affect the use of orphenadrine, aspirin, and caffeine. Make sure you tell your doctor if you have any other medical problems, especially:

- Bladder problem or
- Enlarged prostate or
- Esophagus problem (eg, achalasia) or
- Glaucoma or
- Myasthenia gravis or
- Stomach or bowel blockage (eg, pyloric or duodenal obstruction)—Should not be used in patients with these conditions.

- Blood clotting problem or
- Stomach ulcer—Use with caution. May increase risk for more side effects.

## Related/similar drugs

acetaminophen, ibuprofen, Tylenol, cyclobenzaprine, Paracetamol, diclofenac, naproxen

## Proper use of orphenadrine, aspirin, and caffeine

Take orphenadrine, aspirin, and caffeine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

You may take orphenadrine, aspirin, and caffeine with or without food.

### Dosing

The dose of orphenadrine, aspirin, and caffeine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of orphenadrine, aspirin, and caffeine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

- For oral dosage forms (tablets):
  - For mild to moderate muscle or bone pain:
    - Adults and children older than 12 years of age—One-half or one tablet 3 or 4 times a day. Each tablet contains 50 milligrams (mg) orphenadrine, 770 mg aspirin, and 60 mg caffeine.
    - Children younger than 12 years of age—Use is not recommended.

### Missed dose

If you miss a dose of orphenadrine, aspirin, and caffeine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

### Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

## Precautions while using orphenadrine, aspirin, and caffeine

It is very important that your doctor check your or your child's progress, especially if you will be using orphenadrine, aspirin, and caffeine for a long time. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it. Blood and urine tests may be needed to check for unwanted effects.

Using orphenadrine, aspirin, and caffeine during the later part of pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

Orphenadrine, aspirin, and caffeine contains aspirin, which may cause a condition called Reye's syndrome, especially in children with or recovering from a viral infection (including chicken pox, influenza). Do not give orphenadrine, aspirin, and caffeine in these patients, unless ordered by your doctor. Talk to your doctor if you have concerns.

Orphenadrine, aspirin, and caffeine may cause confusion, tremors, or lightheadedness, or make you less alert than you are normally. Do not drive or do anything else that could be dangerous until you know how orphenadrine, aspirin, and caffeine affects you. Sit or lie down if you feel dizzy. Stand up carefully.

Check with your doctor right away if you have black, tarry stools, chest pain, chills, cough, fever, painful or difficult urination, rash, sore throat, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, swollen glands, trouble breathing, unusual bleeding or bruising, or unusual tiredness or weakness. These may be symptoms of serious skin reaction called drug with eosinophilia with systemic syndrome (DRESS).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or non-prescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

## Orphenadrine, aspirin, and caffeine side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

- Agitation
- anxiety
- confusion
- fast or irregular breathing
- irritability
- nervousness
- nightmares
- restlessness
- seeing, hearing, or feeling things that are not there
- seizures
- tremors
- unusual feeling of excitement

Rare

- Black, tarry stools
- chest pain or tightness
- chills
- cough
- fever
- headache
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swollen or painful glands
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds

Incidence not known

- Decrease in the frequency of urination or urine volume
- difficulty in passing urine (dribbling)
- dizziness
- fainting
- fast, pounding, or irregular heartbeat or pulse
- lightheadedness
- painful urination

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

- Blurred vision
- constipation
- drowsiness
- dry mouth
- itching, red, skin rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Aspirin / caffeine / orphenadrine side effects (more detail)

## More about aspirin / caffeine / orphenadrine

- Check interactions
- Pricing & coupons
- Reviews (23)
- Drug images
- Side effects
- Drug class: skeletal muscle relaxant combinations
- En español

### Patient resources

- Drug Information
- Orphenadrine, Aspirin, and Caffeine

#### Other brands

Norgesic, Norgesic Forte, Orphengesic Forte, Orphengesic

### Professional resources

- Prescribing Information

### Related treatment guides

- Muscle Pain
- Muscle Spasm

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer