Uretron D/S Advanced Patient Information - Drugs.com

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# Uretron D/S (Oral)

Generic name: hyoscyamine, methenamine, methylene blue, phenyl salicylate, and sodium phosphate (oral route) [ hye-oh-SYE-a-meen-SUL-fate, meth-EN-a-meen, METH-i-leen-BLOO, FEN-il-sal-I-si-late, SOE-dee-um-FOS-fate, mono-BAY-sik ]
Drug class: Urinary antispasmodics

Medically reviewed by Drugs.com. Last updated on Jul 19, 2022.

## Commonly used brand name(s)

In the U.S.

- Phosphasal
- Urelle
- Uretron D/S
- Uribel
- Urimar-T
- UR N-C
- Ustell
- Uticap
- Utira-C
- Utrona-C

Available Dosage Forms:

- Tablet
- Capsule

Therapeutic Class: Urinary Antispasmodic

Pharmacologic Class: Hyoscyamine

Chemical Class: Salicylate, Non-Aspirin

## Uses for Uretron D/S

Urelle® is a combination of five medicines: hyoscyamine, methenamine, methylene blue, phenyl salicylate, and sodium phosphate. It is used to relieve discomfort, swelling, pain, frequent urge to urinate, and cramps or spasms of the urinary tract caused by an infection or a diagnostic procedure.

Hyoscyamine is an antispasmodic drug, which relieves muscle cramps or spasms. Methenamine and methylene blue are antiseptic drugs, which help clear a urinary tract infection. Phenyl salicylate is a pain reliever. Sodium phosphate makes the urine more acidic, which helps methenamine work better.

This medicine is available only with your doctor's prescription.

## Before using Uretron D/S

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

### Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

### Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Urelle® in children. However, use is not recommended in children 6 years of age and younger.

### Geriatric

No information is available on the relationship of age to the effects of Urelle® in geriatric patients.

### Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

### Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

- Acetazolamide
- Amitriptyline
- Amoxapine
- Amphetamine
- Atomoxetine
- Benzphetamine
- Bepridil
- Bupropion
- Burosumab-twza
- Carbamazepine
- Carbidopa
- Carbinoxamine
- Cisapride
- Citalopram
- Clomipramine
- Codeine
- Cyclobenzaprine
- Desipramine
- Desvenlafaxine
- Deutetrabenazine
- Dexmethylphenidate
- Dextroamphetamine
- Doxepin
- Doxylamine
- Dronedarone
- Duloxetine
- Entacapone
- Escitalopram
- Fenfluramine
- Fluoxetine
- Fluvoxamine
- Hydroxytryptophan
- Imipramine
- Isocarboxazid
- Levodopa
- Levoketoconazole
- Levomilnacipran
- Linezolid
- Lisdexamfetamine
- Mafenide
- Maprotiline
- Meperidine
- Mesoridazine
- Methamphetamine
- Methylphenidate
- Milnacipran
- Mirtazapine
- Nortriptyline
- Ozanimod
- Paroxetine
- Phenelzine
- Phentermine
- Pimozide
- Piperaquine
- Potassium
- Potassium Citrate
- Protriptyline
- Pseudoephedrine
- Rizatriptan
- Safinamide
- Saquinavir
- Selegiline
- Serdexmethylphenidate
- Sertraline
- Silver Sulfadiazine
- Solriamfetol
- Sparfloxacin
- Sulfabenzamide
- Sulfacetamide
- Sulfacytine
- Sulfadiazine
- Sulfamerazine
- Sulfamethazine
- Sulfamethoxazole
- Sulfanilamide
- Sulfapyridine
- Sulfasalazine
- Sulfathiazole
- Sulfisoxazole
- Sumatriptan
- Tapentadol
- Terfenadine
- Thioridazine
- Tramadol
- Tranylcypromine
- Trazodone
- Trimipramine
- Tryptophan
- Venlafaxine
- Vilazodone
- Viloxazine
- Vortioxetine
- Ziprasidone
- Zolmitriptan
- Zonisamide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

- Aceclofenac
- Acemetacin
- Alfentanil
- Alfuzosin
- Almotriptan
- Alprazolam
- Amifampridine
- Amineptine
- Amiodarone
- Amisulpride
- Amitriptyline
- Amitriptylinoxide
- Amoxapine
- Amtolmetin Guacil
- Anagrelide
- Apomorphine
- Aripiprazole
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Asenapine
- Astemizole
- Atropine
- Azithromycin
- Balsalazide
- Bedaquiline
- Benzhydrocodone
- Bismuth Subsalicylate
- Bromazepam
- Bromfenac
- Brompheniramine
- Bufexamac
- Buprenorphine
- Bupropion
- Buserelin
- Buspirone
- Butorphanol
- Calcium Oxybate
- Cannabidiol
- Celecoxib
- Ceritinib
- Cetirizine
- Chloroquine
- Chlorpheniramine
- Chlorpromazine
- Choline Magnesium Trisalicylate
- Choline Salicylate
- Ciprofloxacin
- Citalopram
- Clarithromycin
- Clobazam
- Clofazimine
- Clomipramine
- Clonazepam
- Clonixin
- Clothiapine
- Clozapine
- Cocaine
- Crizotinib
- Dabrafenib
- Daridorexant
- Dasatinib
- Degarelix
- Delamanid
- Desipramine
- Deslorelin
- Deutetrabenazine
- Dexibuprofen
- Dexketoprofen
- Dexmedetomidine
- Dextromethorphan
- Dibenzepin
- Diclofenac
- Difenoxin
- Diflunisal
- Dihydrocodeine
- Diphenoxylate
- Dipyrone
- Disopyramide
- Dofetilide
- Dolasetron
- Domperidone
- Donepezil
- Droperidol
- Droxicam
- Efavirenz
- Eletriptan
- Encorafenib
- Entrectinib
- Epinephrine
- Erdafitinib
- Erythromycin
- Escitalopram
- Esketamine
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Fenoprofen
- Fentanyl
- Fepradinol
- Feprazone
- Fexinidazole
- Fingolimod
- Flecainide
- Flibanserin
- Floctafenine
- Fluconazole
- Flufenamic Acid
- Fluoxetine
- Flurbiprofen
- Formoterol
- Foscarnet
- Fostemsavir
- Frovatriptan
- Furazolidone
- Gabapentin
- Gabapentin Enacarbil
- Gatifloxacin
- Gemifloxacin
- Glasdegib
- Glucagon
- Glycopyrrolate
- Glycopyrronium Tosylate
- Gonadorelin
- Goserelin
- Granisetron
- Halofantrine
- Haloperidol
- Histrelin
- Hydrocodone
- Hydromorphone
- Hydroxychloroquine
- Hydroxyzine
- Ibuprofen
- Ibutilide
- Iloperidone
- Imipramine
- Indomethacin
- Inotuzumab Ozogamicin
- Iobenguane I 123
- Iobenguane I 131
- Iproniazid
- Ivabradine
- Ivosidenib
- Ketamine
- Ketoconazole
- Ketoprofen
- Lapatinib
- Lasmiditan
- Lefamulin
- Lemborexant
- Lenvatinib
- Leuprolide
- Levocetirizine
- Levofloxacin
- Levorphanol
- Lithium
- Lofepramine
- Lofexidine
- Lopinavir
- Lorcaserin
- Lornoxicam
- Loxapine
- Loxoprofen
- Lumefantrine
- Lumiracoxib
- Macimorelin
- Magnesium Oxybate
- Magnesium Salicylate
- Meclofenamate
- Mefenamic Acid
- Mefloquine
- Melitracen
- Meloxicam
- Mesalamine
- Metaxalone
- Methacholine
- Methadone
- Metoclopramide
- Metronidazole
- Midodrine
- Mifepristone
- Mirtazapine
- Mobocertinib
- Moclobemide
- Morniflumate
- Morphine
- Morphine Sulfate Liposome
- Moxifloxacin
- Nabumetone
- Nafarelin
- Nalbuphine
- Naproxen
- Naratriptan
- Nefazodone
- Nepafenac
- Nialamide
- Niflumic Acid
- Nilotinib
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Norepinephrine
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olsalazine
- Ondansetron
- Opipramol
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxaprozin
- Oxycodone
- Oxymetazoline
- Oxymorphone
- Oxyphenbutazone
- Ozanimod
- Pacritinib
- Paliperidone
- Palonosetron
- Panobinostat
- Parecoxib
- Pasireotide
- Pazopanib
- Pentazocine
- Periciazine
- Phenylbutazone
- Piketoprofen
- Pimavanserin
- Piroxicam
- Pitolisant
- Ponesimod
- Posaconazole
- Potassium Oxybate
- Pregabalin
- Procainamide
- Procarbazine
- Prochlorperazine
- Proglumetacin
- Promethazine
- Propafenone
- Propyphenazone
- Proquazone
- Protriptyline
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Rasagiline
- Remifentanil
- Remimazolam
- Revefenacin
- Ribociclib
- Rofecoxib
- Ropeginterferon Alfa-2b-njft
- Salicylamide
- Salicylic Acid
- Salsalate
- Scopolamine
- Secretin Human
- Selpercatinib
- Sertraline
- Sevoflurane
- Sibutramine
- Siponimod
- Sodium Oxybate
- Sodium Salicylate
- Solifenacin
- Sorafenib
- Sotalol
- St John's Wort
- Sufentanil
- Sulfasalazine
- Sulindac
- Sulpiride
- Sunitinib
- Tacrolimus
- Telavancin
- Telithromycin
- Tenoxicam
- Tetrabenazine
- Tianeptine
- Tiaprofenic Acid
- Tiotropium
- Tolfenamic Acid
- Tolmetin
- Trazodone
- Triclabendazole
- Trimipramine
- Triptorelin
- Trolamine Salicylate
- Valbenazine
- Valdecoxib
- Vandetanib
- Vardenafil
- Vemurafenib
- Vilanterol
- Vinflunine
- Voclosporin
- Voriconazole
- Ziprasidone
- Zolpidem
- Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

- Acarbose
- Aluminum Carbonate, Basic
- Aluminum Hydroxide
- Aluminum Phosphate
- Calcium Acetate
- Calcium Carbonate
- Calcium Citrate
- Chlorpropamide
- Dihydroxyaluminum Aminoacetate
- Dihydroxyaluminum Sodium Carbonate
- Glimepiride
- Glipizide
- Glyburide
- Insulin
- Insulin Aspart, Recombinant
- Insulin Bovine
- Insulin Degludec
- Insulin Detemir
- Insulin Glargine, Recombinant
- Insulin Glulisine
- Insulin Lispro, Recombinant
- Magaldrate
- Magnesium Carbonate
- Magnesium Hydroxide
- Magnesium Oxide
- Magnesium Trisilicate
- Metformin
- Nateglinide
- Repaglinide
- Tolazamide
- Tolbutamide

### Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

### Other medical problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

- Congestive heart failure or
- Coronary heart disease or
- Glaucoma or
- Heart disease (e.g., mitral stenosis) or
- Heart rhythm problems (e.g., arrhythmia) or
- Myasthenia gravis (severe muscle weakness) or
- Stomach or intestinal (bowel) blockage or
- Stomach ulcers or
- Urinary problems (e.g., bladder blockage due to an enlarged prostate)—Use with caution. May make these conditions worse.

- Allergy or intolerance to belladonna or salicylates—Use with caution. May be sensitive to this medicine also.

## Proper use of Uretron D/S

This section provides information on the proper use of a number of products that contain hyoscyamine, methenamine, methylene blue, phenyl salicylate, and sodium phosphate. It may not be specific to Uretron D/S. Please read with care.

Take this medicine for the full time of treatment, even if you begin to feel better. Also, keep your appointments with your doctor for check-ups so that your doctor will be better able to tell you when to stop taking this medicine.

Drink extra fluids after you take this medicine so you will pass more urine.

### Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

- For oral dosage form (tablets):
  - For treatment of symptoms of urinary tract infection or diagnostic procedure:
    - Adults—One tablet four times a day
    - Children 7 years of age and older—Use and dose must be determined by your doctor.
    - Children 6 years of age and younger—Use is not recommended.

### Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

### Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Uretron DS dosage information

## Precautions while using Uretron D/S

It is very important that your doctor check the progress of you or your child at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

If your or your child's symptoms do not improve or if they get worse, call your doctor.

Stop using this medicine and check with your doctor right away if you or your child have blurred vision, dizziness, or rapid pulse.

This medicine will make your urine to be colored blue. This is normal and is nothing to worry about.

This medicine will not cure a serious urinary tract infection and will only work to relieve symptoms as long as you continue to take it.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

## Uretron D/S side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

- Blurred vision
- dizziness
- rapid pulse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

- Blue-colored urine

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Uretron DS side effects (more detail)

## More about Uretron DS (hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate)

- Check interactions
- Drug images
- Side effects
- Dosage information
- Drug class: urinary antispasmodics

### Patient resources

- Patient Information

#### Other brands

Uribel, Vilamit MB, Urelle, Ustell, ... +15 more

### Professional resources

- Prescribing Information

### Related treatment guides

- Urinary Tract Infection

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer