Vemurafenib Uses, Side Effects & Warnings - Drugs.com

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# Vemurafenib

Generic name: vemurafenib [ VEM-ue-RAF-e-nib ]
Brand name: Zelboraf
Dosage form: oral tablet (240 mg)
Drug class: Multikinase inhibitors

Medically reviewed by Drugs.com on Mar 15, 2022. Written by Cerner Multum.

## What is vemurafenib?

Vemurafenib is used to treat melanoma (skin cancer) that has spread to other parts of the body or cannot be removed by surgery.

Vemurafenib is also used to treat Erdheim-Chester Disease (a rare blood cancer).

Vemurafenib is used only if your cancer has a specific genetic marker (an abnormal "BRAF" gene). Your doctor will test you for this gene.

Vemurafenib may also be used for purposes not listed in this medication guide.

## Warnings

Vemurafenib is used to treat melanoma, but vemurafenib can increase your risk of developing other types of skin cancer. Report any new or worsening skin lesions to your doctor right away.

Many drugs can interact with vemurafenib. Tell your doctor about all your current medicines and any you start or stop using

## Before taking this medicine

You should not use vemurafenib if you are allergic to it.

Tell your doctor if you have ever had:

- liver or kidney disease;

- heart problems;

- long QT syndrome (in you or a family member); or

- an electrolyte imbalance (such as low levels of calcium, potassium, or magnesium in your blood).

Tell your doctor about all radiation treatments you are scheduled to receive, or have received in the past.

Using vemurafenib may increase your risk of developing other types of skin cancer. Report any new or worsening skin lesions to your doctor right away.

Vemurafenib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine, and for 2 weeks after your last dose. Tell your doctor if you become pregnant.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

## How should I take vemurafenib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take the medicine every 12 hours, with or without food.

Swallow the tablet whole and do not crush, chew, or break it.

If you vomit shortly after taking vemurafenib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

You will need frequent medical tests.

To make sure vemurafenib is not causing harmful effects, your skin condition will need to be checked often. Your heart function may also need to be tested with an electrocardiogram (ECG or EKG) on a regular basis. You may also need eye exams. Your cancer treatments may be delayed based on the results of these tests.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Your doctor may want to check your skin for several months after you stop using vemurafenib. Visit your doctor regularly.

## Related/similar drugs

Keytruda, pembrolizumab, nivolumab, Opdivo, dabrafenib, ipilimumab, Zelboraf

## What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 4 hours. Do not use two doses at one time.

## What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

## What should I avoid while taking vemurafenib?

Vemurafenib could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

## Vemurafenib side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Vemurafenib may cause serious side effects. Stop using vemurafenib and call your doctor at once if you have:

- skin changes--a new wart or lesion, a skin sore or red bump that bleeds or does not heal, or any change in the size or color of a mole;

- unusual thickening of tissues under the skin on the palms of your hands or the soles of your feet;

- a finger or fingers that feel tight or are bent inward;

- fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

- eye problems--vision changes, eye pain or swelling, severe eye redness, small white or yellow patches on the surface of your eye; or

- liver problems--stomach pain (upper right side), nausea, vomiting, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects of vemurafenib may include:

- joint pain;

- feeling tired;

- nausea;

- hair loss;

- mild rash or itching;

- skin growths; or

- sunburn, increased sensitivity to sunlight.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Vemurafenib side effects (more detail)

## Vemurafenib dosing information

Usual Adult Dose for Melanoma -- Metastatic:

960 mg orally every 12 hours until disease progression or unacceptable toxicity
Comments:
-Confirm the presence of BRAF V600E mutation in tumor specimens prior to initiation of therapy.
Use: BRAF V600 mutation-positive unresectable or metastatic melanoma

Usual Adult Dose for Histiocytosis:

960 mg orally every 12 hours until disease progression or unacceptable toxicity
Comments:
-Confirm the presence of BRAF V600E mutation in tumor specimens prior to initiation of therapy.
Use: For Erdheim-Chester Disease (ECD) with BRAF V600 mutation

Detailed Vemurafenib dosage information

## What other drugs will affect vemurafenib?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect vemurafenib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Vemurafenib drug interactions (more detail)

## Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

## More about vemurafenib

- Check interactions
- Reviews (4)
- Side effects
- Dosage information
- During pregnancy
- Drug class: multikinase inhibitors
- Breastfeeding
- En español

### Patient resources

- Advanced Reading

#### Other brands

Zelboraf

### Professional resources

- Prescribing Information

### Related treatment guides

- Erdheim-Chester Disease
- Melanoma, Metastatic

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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