Percogesic Original Strength Uses, Side Effects & Warnings - Drugs.com

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# Percogesic Original Strength

Generic name: acetaminophen and diphenhydramine [ a-SEET-a-MIN-oh-fen-and-DYE-fen-HYE-dra-meen ]
Brand names: Headache Relief PM, Legatrin PM, Midol PM, Percogesic Original Strength, Tylenol PM
Drug class: Analgesic combinations

Medically reviewed by Drugs.com on Sep 19, 2022. Written by Cerner Multum.

## What is Percogesic Original Strength?

Acetaminophen is a pain reliever and a fever reducer. Diphenhydramine is an antihistamine.

Percogesic Original Strength is a combination medicine used to treat occasional insomnia associated with minor aches and pains. Percogesic Original Strength is not for use in treating sleeplessness without pain, or sleep problems that occur often.

Percogesic Original Strength is also used to treat minor aches and pains such as headache, back pain, joint or muscle pain, tooth pain, or menstrual cramps.

Percogesic Original Strength is also used to treat runny nose, sneezing, itchy nose and throat, and pain or fever caused by allergies, the common cold, or the flu.

Percogesic Original Strength may also be used for purposes not listed in this medication guide.

## Warnings

Use this medicine exactly as directed. An overdose of acetaminophen can damage your liver or cause death. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.

Do not use this medicine to make a child sleepy. This medicine is not for use in anyone younger than 12 years old.

Ask a doctor or pharmacist before using any other medicine that may contain acetaminophen or diphenhydramine. Taking too much of either medicine can lead to a fatal overdose.

Drinking alcohol may increase your risk of liver damage while taking acetaminophen.

Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

## Related/similar drugs

Buprenex, aspirin, acetaminophen, ibuprofen, tramadol, amitriptyline, Tylenol

## Before taking this medicine

Ask a doctor before taking medicine that contains acetaminophen if you have ever had liver disease, or if you drink more than 3 alcoholic beverages per day.

Ask a doctor or pharmacist if Percogesic Original Strength is safe to use if you have ever had:

- liver disease;

- an enlarged prostate or urination problems;

- asthma, chronic obstructive pulmonary disease (COPD), emphysema, or other breathing disorder;

- glaucoma; or

- a condition for which you take warfarin (Coumadin, Jantoven).

Ask a doctor before using this medicine if you are pregnant or breastfeeding. Diphenhydramine may slow breast milk production.

## How should I take Percogesic Original Strength?

Use exactly as directed on the label, or as prescribed by your doctor. Percogesic Original Strength is only for short-term use until your symptoms clear up.

Do not take more of this medicine than is recommended. An overdose of acetaminophen can damage your liver or cause death. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.

Percogesic Original Strength is not for use in anyone younger than 12 years old. Do not use the medicine to make a child sleepy. Death can occur from the misuse of antihistamines in very young children.

Do not use this medicine for longer than 2 weeks to treat sleep problems, or longer than 7 days to treat cold or allergy symptoms.

Call your doctor if you still have a fever after 3 days, or you still have pain after 10 days (or 5 days if you are 12-17 years old). Also call your doctor if your symptoms get worse, or if you have any redness or swelling.

If you need surgery or medical tests, tell the doctor ahead of time if you have taken this medicine within the past few days.

Store at room temperature away from moisture and heat.

Detailed Percogesic Original Strength dosage information

## What happens if I miss a dose?

Since Percogesic Original Strength is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

## What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal or cause liver damage.

Overdose symptoms may include loss of appetite, vomiting, weakness, confusion, ringing in your ears, upper stomach pain, dark urine, no urination, very dry eyes and mouth, yellowing of your skin or eyes, dilated pupils, fast heartbeats, tremor, agitation, hallucinations, or seizure.

## What should I avoid while taking Percogesic Original Strength?

Avoid driving or hazardous activity until you know how Percogesic Original Strength will affect you. Your reactions could be impaired.

Ask a doctor or pharmacist before using any other medicine that may contain acetaminophen or diphenhydramine. This includes medicines for pain, fever, swelling, cold/flu symptoms, or anti-itch medicine used on the skin. Using too much acetaminophen or diphenhydramine can lead to a fatal overdose.

Drinking alcohol may increase your risk of liver damage while taking acetaminophen.

## Percogesic Original Strength side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

The medicine may cause serious side effects. Stop using the medicine and call your doctor at once if you have:

- severe drowsiness;

- painful or difficult urination; or

- liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects of Percogesic Original Strength may include:

- drowsiness;

- constipation;

- decreased urination;

- dry eyes, blurred vision; or

- dry mouth, nose, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Percogesic Original Strength side effects (more detail)

## What other drugs will affect Percogesic Original Strength?

Ask a doctor or pharmacist before using Percogesic Original Strength with any other medicines, especially drugs that can cause drowsiness (such as opioid medication, sleep medicine, a muscle relaxer, or medicine for anxiety or seizures). Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Percogesic Original Strength drug interactions (more detail)

## Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

## More about Percogesic Original Strength (acetaminophen / diphenhydramine)

- Check interactions
- Reviews (18)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: analgesic combinations
- En español

### Patient resources

#### Other brands

Tylenol PM, Headache Relief PM, Legatrin PM, Midol PM, Tylenol Severe Allergy

### Other formulations

- Percogesic Extra Strength

### Related treatment guides

- Headache
- Insomnia
- Pain

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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