Siberian Ginseng Uses, Benefits & Dosage - Drugs.com Herbal Database

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# Siberian Ginseng

Scientific Name(s): Eleutherococcus senticosus ﻿(Rupr. et Maxim.) Maxim
Common Name(s): Ciwujia, Devil's shrub, Eleuthero, Eleutherococcus, Ezoukogi, Kan Jang, Shigoka, Siberian ginseng, Touch-me-not, Wild pepper, Wujiasheng, Wushaseng

Medically reviewed by Drugs.com. Last updated on Jan 11, 2022.

## Clinical Overview

### Use

Eleutherococcus is similar to common ginseng in its properties and alleged effects; however, documentation is limited. Extracts of the root have been used for a wide variety of therapeutic purposes and are said to have an adaptogenic effect. It exhibits cardiovascular as well as mood- and energy-enhancing effects.

### Dosing

Doses of powdered root 1 to 4 g per day have been used in trials. Doses of E. senticosus extracts are recommended at less than 1 g/day. Limited trials have been conducted in elderly patients and in children.

### Contraindications

Information is lacking. Patients in a compromised state, who are febrile, or have unstable cardiovascular or diabetic conditions should not use eleutherococcus.

### Pregnancy/Lactation

Information regarding safety and efficacy during pregnancy and lactation is lacking; however, because of a potential effect on developing myocytes, consider Siberian ginseng contraindicated during pregnancy.

### Interactions

Interactions with digoxin and hexobarbital have been described. Mechanisms for interaction are not established.

### Adverse Reactions

Few adverse reactions have been reported.

### Toxicology

Use of eleutherococcus extract has been associated with little or no toxicity.

## Scientific Family

- Araliaceae

## Botany

E. senticosus belongs to the same family (Araliceae) as Panax ginseng and is synonymous with Acanthopanax senticosus (Rupr. ex Maxim.) Harms. The geographical distribution of eleutherococcus coincides with that of P. ginseng in forests of broadleaf trees, including spruce and cedar. It grows at elevations of up to 800 m or more above sea level. The plant is a shrub, commonly growing to a height of 2 to 3 m or, less commonly, 5 to 7 m. It has gray or grayish-brown bark, numerous thin thorns, and long-stalked and palmate leaves. Eleutherococcus has separate male and female plants with globular umbrella-shaped flowers. Male plants produce violet flowers, while female plants have yellowish flowers; the fruit are black, oval berries. Most commonly, the root is used in herbal medicine; however, the leaves and berries also produce pharmacologically active metabolites. Because it grows abundantly in areas such as Russia and China, eleutherococcus has become a popular substitute for Chinese ginseng.Brekhman 1980, USDA 2006

## History

Eleutherococcus has been used and studied extensively in Russia. It is used as a health food, tonic, and sedative in China and wider Asia, as well as in traditional Korean folk medicine as a tonic, an adaptogen, and to strengthen "qi" (life force).Bu 2005, Park 2004

As with its relative Chinese ginseng, root extracts of the plant have been promoted as "adaptogens," which aid the body in responding to external (eg, environmental) and internal (eg, disease) stress. The plant extract has been traditionally used to normalize high or low blood pressure, to stimulate the immune system, and to increase work capacity. Reputed effects include increasing body energy levels, protecting from motion sickness and against toxins, controlling alloxan-induced diabetes, reducing tumors, and controlling atherosclerosis.Brekhman 1980, Brekhman 1991

## Related/similar drugs

Ginkgo Biloba, turmeric, saw palmetto

## Chemistry

The chemical composition of the roots and leaves varies with season. The roots contain the maximum active ingredient in October, with the level dropping sharply in July. Methanolic extracts of eleutherococcus root contain a glycoside fraction that includes various eleutherosides (isofraxidin, sesamin, syringin) as well as glucose, sucrose, betulinic acid, vitamin E, beta-carotene, caffeic acid, and beta-sitosterol. The eleutherosides found in the roots, leaves, and berries are designated as A through M and have varied structures belonging to different groups of chemical compounds.Brekhman 1980, Farnsworth 1985

Several studies have differentiated between the botany, chemistry, and pharmacology of common ginseng (P. ginseng and P. quinquefolium) and Siberian ginseng (E. senticosus).Wagner 1994 Only eleutheroside A has a saponin structure similar to that of ginseng ginsenosides/panaxosides.Wagner 1977 While some eleutherosides share common properties with panaxosides, others exhibit very different effects. Seven glycans (eleutherans A, B, C, D, E, F, and G) have been isolated from aqueous extract of the crude drug shigoka (Siberian ginseng) root.Hikino 1986 The following new lignans have been isolated from the root of eleutherococcus: 7SR,8RS-dihydrodrodiconiferyl alcohol, dehydrodiconiferyl alcohol, 7,8-trans-dihydrodehydrodiconiferyl alcohol-4-O-beta-D- glucopyranoside, meso-secoisolariciresinol, and (-)-syringoresinol-4-O-beta-D-glucopyranoside.Makarieva 1997 The antiplatelet compound 3,4-dihydroxybenzoic acid has also been isolated from this species.Yun-Choi 1987 Eleutherosides have been isolated, identified, and measured in the rhizomes, roots, and liquid extracts of eleutherococcus.Solovyeva 1989 Other relatively new compounds that have been isolated include phenylpropanes and polysaccharides, ciwujianosides C1 and D1Umeyama 1992 and at least 10 phenolic compounds such as isofraxidin.Nishibe 1990 Chemical analysis methods for eleutherococcus, such as reversed phase high-performance liquid chromatography, have been published.Anetai 1995, Chen 1999, Yat 1998

## Uses and Pharmacology

Many clinical studies in the literature use combinations of several natural products, including eleutherococcus, making it difficult to attribute outcomes to any single plant or extract.

### Anti-inflammatory effects

#### Experimental data

Results from in silico studies predict eleutheroside B to have anti-inflammatory activity that may be similar to meclofenamic acid based on molecular docking to the cyclo-oxygenase-2 (COX-2) enzyme.(Ahmed 2021) Strong inhibition of eicosanoid signaling was exhibited by E. senticosus root extract in neuroglial cells, which decreased gene expression of ALOX12 by 7.4-fold, the arachidonic acid enzyme associated with neurotoxicity. Additionally, a 3.7-fold decrease was seen with ALOX5AP that is associated with inflammation, chemotaxis, allergic asthma, Alzheimer disease, tau phosphorylation, and vascular permeability. In contrast, the extract increased gene expression of PTGER3 related to bicarbonate secretion that reduces damage to the duodenum and is also associated with reducing allergic reactivity, fever, and pain.(Panossian 2019)

Aqueous extracts of Siberian ginseng showed a protective effect in transient focal cerebral ischemia induced by artery occlusion in rats, possibly due to COX-2 inhibition.(Bu 2005)

### Antiviral

#### Clinical data

A 2020 systematic review summarized 6 clinical studies published between 1977 and 1986 that documented reduced complications (ie, pneumonia, bronchitis, genyantritis, otitis), morbidity, and mortality rates related to influenza infections in adults and children with administration of E. senticosus. Preclinical studies demonstrated efficacy of eleutherodises against human rhinovirus, RSV, and H1N1.(Panossian 2020)

### Cardiac effects

Although not clearly established, eleutherococcus appears to exert an endothelium dependent, nitric oxide-mediated vascular relaxation.(Kwan 2004)

#### Animal data

At high dosages, Siberian ginseng led to abrupt cessation of myocardial contractions in rats with increased levels of intracellular calcium. At low doses, the extract induced cells to beat with a regular and strong rhythm and had no effect on calcium levels, suggesting a negative effect on developing fetal myocytes.(Poindexter 2006) In mice with pressure overload-induced cardiac hypertrophy, the eleutherococcus extract syringin decreased the expression of hypertrophic markers attenuating hypertrophy by mechanisms that appeared to be most closely related to autophagy.(Li 2017)

#### Clinical data

In a study that examined the effects of eleutherococcus in hypotensive children between 7 and 10 years of age, an eleutherococcus extract improved subjective signs, raised systolic and diastolic blood pressures, and increased total peripheral resistance.(Kaloeva 1986) In another study in 20 hypertensive elderly patients, no effect on blood pressure was found at 300 mg/day of dry extract. Higher dosages were not studied.(Cicero 2004)

Other reported cardiovascular actions include effects in myocardial infarction(Afanaseva 1987) malignant arrhythmias(Tian 1989) and myocarditis.(Shang 1991)

### Chronic fatigue/mental stress

In a review of older studies, a trend toward improved performance in mental tasks was observed.(Panossian 2005)

#### Clinical data

A study investigating the effect of eleutherococcus 2 g/day in adults with chronic idiopathic fatigue showed an improvement after 1 month, but this effect was not sustained at 2 months.(Hartz 2004) In a study in elderly patients, self-reported mental health and social functioning was enhanced by administration of dry eleutherococcus extract 300 mg for 4 weeks. With continued use of the extract, these differences were attenuated(Cicero 2004) possibly consistent with the concept that adaptogens should only be used in a "pulsed" manner. Similarly, supplementation with E. senticosus for 8 weeks alone or in combination with stress management techniques did not produce any difference in salivary cortisol concentrations compared to stress management alone in adults with asthenia and chronic stress. The trial was an unblinded, randomized controlled study conducted in 144 adults with reduced work capacity.(Lopresti 2021)

### CNS

#### Animal and experimenta data

In vitro studies support anti-inflammatory and a neuroprotective effects of Siberian ginseng that include downregulation of arachidonic acid signaling pathwatys involved in neurotoxicity, Alzheimer disease, neuronal survival, neurogenesis, neuroinflammation, blood-brain barrier integrity, plaque load, and Tau physophorylation.(Panossian 2019)

Aqueous extracts of Siberian ginseng showed a protective effect, possibly due to COX-2 inhibition, in transient focal cerebral ischemia induced by artery occlusion in rats.(Bu 2005) Oral administration of E. senticosus leaf aqueous extract in mice for 17 days significantly improved object recognition memory but did not affect memory retention or locomotion. Leaf extract compounds were identified in the cerebral cortex within 3 hours of administration indicating that cognitive effects were associated with penetration of Siberian ginseng across the blood-brain barrier.(Yamauchi 2019)

### Diabetes

#### Animal data

In an animal study of endurance, oral administration of eleutherococcus extract did not affect plasma lactic acid, glucagon, insulin, or liver glycogen. Decreased plasma glucose levels were found in resting rats.(Martinez 1984)

#### Clinical data

In a small trial in healthy, nondiabetic adults, postprandial glucose levels were raised following eleutherococcus administration,(Sievenpiper 2004) suggesting that caution should be used when administering the product to diabetic patients.

### Hepatoprotective

#### Animal data

Aqueous extracts of the stem of the eleutherococcus plant reduced serum tumor necrosis factor and aspartate and alanine transaminases, improved histology, and inhibited hepatocyte apoptosis in mice with induced hepatic failure.(Park 2004)

### Immunomodulation

#### Clinical data

Some studies indicated a modulatory effect on the immune system with enhanced T cell and lymphocyte activity(Bohn 1987, Borchers 1998) while others have shown no effect.(Gaffney 2001)

### Insecticidal

The essential oil of E. senticoccus leaves showed moderate activity as a biting deterrent against the dengue mosquito vector, Aedes aegypti, with the alpha-bisabolol moiety exhibiting equivalent activity to DEET in in vitro assays. However, less significant effects were observed in cage-based repellency studies.(Zhai 2017)

### Osteoporosis

#### Animal and in vitro data

A protective effect is suggested based on experiments in induced osteoporotic mice. Decreased urinary excretion of calcium and increased plasma levels of calcium and phosphorous were observed.(Kropotov 2002)

Eleutherococcus extract binds to progesterone, mineralocorticoid, and glucocorticoid receptors.(Pearce 1982) Siberian ginseng extracts exerted no effect on prolactin in rats despite the high concentrations and long periods of exposure used in experimentation.(Di Carlo 2005) Additionally, eleutherococcus compounds bind to estrogen receptors, with no apparent effect in cell cultures.(Bennetau-Pelissero 2004)

### Physical stress/endurance

#### Animal data

In animal experiments, various eleutherosides have been evaluated for endurance effect, with certain compounds more effective than others.(Kimura 2004, Lewis 1983, Martinez 1984)

#### Clinical data

Eleutherococcus has been dubbed the "herb of Russian athletes,"(Gaffney 2001) but both supporting evidence and negative trials exist regarding outcome variables, such as oxygen consumption, respiratory exchange, heart rate, and plasma glucose.(Gaffney 2001) Dosing in these trials has been up to 4 g/day.

Measurements of testosterone and cortisol have shown a detrimental effect on the recovery process similar to that of overtraining.(Gaffney 2001)

### Radioprotective effects

Eleutherococcus extract appears to protect cell cultures from the effects of gamma radiation but to a lesser degree than common ginseng. The mechanism seems to involve alteration of cellular metabolism rather than DNA repair.(Ben-Hur 1981, Minkova 1987)

## Dosing

As an adaptogen, eleutherococcus has been given as powdered root in doses of 1 to 4 g/day.Gaffney 2001

Eleutheroside compounds have 36 to 143 times the physiologic activity of the roots from which they are extracted. Extracts of E. senticosus are recommended at less than 1 g/day.Brekhman 1991

Use in elderly patients and children has been studied to a limited extent.Cicero 2004, Hartz 2004, Kaloeva 1986

## Pregnancy / Lactation

Information regarding safety and efficacy during pregnancy and lactation is lacking.

Because of a potential effect on developing fetal myocytes, use of Siberian (and other) ginseng is contraindicated during pregnancy.Poindexter 2006

## Interactions

Based on experiments with standard comparators (dextromethorphan for CYP2D6 and alprazolam for CYP3A4), it is unlikely that eleutherococcus compounds rely on the CYP-450 pathways for elimination.(Donovan 2003)

The interaction of Siberian ginseng with digoxin has been the subject of many papers and case reports. Interference with the digoxin assay, impaired elimination of digoxin, and possible confounding with compounds other than eleutherococcus have all been suggested as reasons for this apparent effect.(Dasgupta 2003, Dasgupta 2005, Donovan 2003, Kaloeva 1986, McRae 1996)

Mice exhibited increased sleep latency and duration when exposed to eleutherococcus extract and hexobarbital, which may be due to inhibition of hexobarbital metabolism.(Medon 1984)

In rats, no significant effect on the kinetics of warfarin was observed with concomitant "Kan Jang" (mixed eleutherococcus extract preparation) administration.(Hovhannisyan 2006)

Atorvastatin: Ginseng (Siberian) may enhance the hepatotoxic effect of atorvastatin. Monitor therapy.(Laube 2019)

## Adverse Reactions

Adverse reactions, toxicity, contraindications, and warnings similar to those for Panax species (see Ginseng, Panax) apply.

High doses of eleutherococcus are associated with irritability, insomnia, and anxiety. In human trials, few adverse reactions are reported.Bohn 1987, Cicero 2004 Adverse reactions have included skin eruptions, headache, diarrhea, hypertension, and pericardial pain in rheumatic heart patients; however the contraindication of aterial hypertension reported for eleutherococcus has been disputed as not being evidence-based.Schmidt 2014

Eleutherococcus was associated with increased aggressive behavior in mice.Lewis 1983

In a small study, Siberian ginseng demonstrated a hyperglycemic effect in healthy adults so caution should be used when administering to diabetic patients.Sievenpiper 2004 In other reports, adverse reactions have included slight languor or drowsiness immediately after administration, possibly due to a hypoglycemic effect.

## Toxicology

Use of eleutherococcus extract has been associated with little or no toxicity.Brekhman 1980, Wagner 1977, Wagner 1994 No pathologic, cytotoxic, or histologic changes were noted in mice that ingested infusions of the plant for up to 96 days.Lewis 1983

## Index Terms

- Acanthopanax senticosus (Rupr. ex Maxim.) Harms

## References

## Disclaimer

This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.

This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.

## More about siberian ginseng

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Afanaseva TN, Lebkova NP. Effect of Eleutherococcus on the subcellular structures of the heart in experimental myocardial infarct [in Russian]. Biull Eksp Bio Med. 1987;103:212-215.
Ahmed S, Moni DA, Sonawane KD, Paek KY, Shohael AM. A comprehensive in silico exploration of pharmacological properties, bioactivities and COX-2 inhibitory potential of eleutheroside B from Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. J Biomol Struct Dyn. 2021;39(17):6553-6566.32757816
Anetai M, Yamagishi T, Kaneshima H. Determination of some constituents in Acanthopanax senticosus Harms. Ill. Differences among part, diameter, age, and harvest time. Hokkaidoritsu Eisei Kenkyushoho. 1995;45:63-65.
Ben-Hur E, Fulder S. Effect of Panax ginseng saponins and Eleutherococcus senticosus on survival of cultured mammalian cells after ionizing radiation. Am J Chin Med. 1981;9:48-56.7304498
Bennetau-Pelissero C, Latonnelle KG, Lamothe V, Shinkaruk-Poix S, Kaushik SJ. Screening for oestrogenic activity of plant and food extracts using in vitro trout hepatocyte cultures. Phytochem Anal. 2004;15:40-45.
Bohn B, Nebe CT, Birr C. Flow-cytometric studies with Eleutherococcus senticosus extract as an immunomodulatory agent. Arzneimittelforschung. 1987;37:1193-1196.2963645
Borchers AH. Comparative effects of three species of ginseng on human peripheral blood lymphocyte proliferative responses. Int J Immunother. 1998;14:143-152.
Brekhman I, Favorov VV, Abramov AK, et al. Comparative study of Eleutherococcus preparations made from raw material of various origin [in Russian]. Farmatsiia. 1991;40:39-41.
Brekhman I, Fulder S. Man and Biologically Active Substances: The Effect of Drugs, Diet, and Pollution on Health. Oxford: Pergamon Press, 1980.
Bu Y, Jin ZH, Park SY, et al. Siberian ginseng reduces infarct volume in transient focal cerebral ischaemia in Sprague-Dawley rats. Phytother Res. 2005;19:167-169.15852490
Chen G, Lu C, Ma S. Determination of syrgingin in slices of radix Acanthopanax senticosi by RP-HPLC [in Chinese]. Zhongguo Zhong Yao Za Zhi. 1999;24:472-473.
Cicero AF, Derosa G, Brillante R, Bernardi R, Nascetti S, Gaddi A. Effects of Siberian ginseng (Eleutherococcus senticosus maxim.) on elderly quality of life: a randomized clinical trial. Arch Gerontol Geriatr Suppl. 2004;9:69-73.
Dasgupta A, Reyes MA. Effect of Brazilian, Indian, Siberian, Asian, and North American ginseng on serum digoxin measurement by immunoassays and binding of digoxin-like immunoreactive components of ginseng with Fab fragment of antidigoxin antibody (Digibind). Am J Clin Pathol. 2005;124:229-236.16040294
Dasgupta A, Wu S, Actor J, Olsen M, Wells A, Datta P. Effect of Asian and Siberian ginseng on serum digoxin measurement by five digoxin immunoassays. Significant variation in digoxin-like immunoreactivity among commercial ginsengs. Am J Clin Pathol. 2003;119:298-303.12580002
Di Carlo G, Pacilio M, Capasso R, Di Carlo R. Effect on prolactin secretion of Echinacea purpurea, hypericum perforatum and Eleutherococcus senticosus. Phytomedicine. 2005;12:644-647.16194051
Donovan JL, DeVane CL, Chavin KD, Taylor RM, Mardowitz JS. Siberian ginseng (Eleutherococcus senticosus) effects on CYP2D6 and CYP3A4 activity in normal volunteers. Drug Metab Dispos. 2003;31:519-522.12695337
Eleutherococcus senticosus. USDA, NRCS. 2006. The PLANTS Database (http://plants.usda.gov, 14 February 2007). National Plant Data Center, Baton Rouge, LA 70874-4490 USA.
Farnsworth N, Kinghorn AD, Soejarto DD, Waller DP. Siberian ginseng (Eleutherococcus senticosus): Current status as an adaptogen. Econ Med Plant Res. 1985;1:155-215.
Gaffney BT, Hugel HM, Rich PA. The effects of Eleutherococcus senticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes. Life Sci. 2001;70:431-442.11798012
Hartz AJ, Bentler S, Noyes R, et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med. 2004;34:51-61.
Hikino H, Takahashi M, Otake K, Konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod. 1986;49:293-297.3734812
Hovhannisyan AS, Abrahamyan H, Gabrielyan ES, Panossian AG. The effect of Kan Jang extract on the pharmacokinetics and pharmacodynamics of warfarin in rats. Phytomedicine. 2006;13:318-323.16635739
Kaloeva ZD. Effect of the glycosides of Eleutherococcus senticosus on the hemodynamic indices of children with hypotensive states [in Russian]. Farmakol Toksikol. 1986;49:73.3770180
Kimura Y, Sumiyoshi M. Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice. J Ethnopharmacol. 2004;95:447-453.15507373
Kropotov AV, Kolodnyak OL, Koldaev VM. Effects of Siberian ginseng extract and ipriflavone on the development of glucocorticoid-induced osteoporosis. Bull Exp Biol Med. 2002;133:252-254.12360344
Kwan CY, Zhang WB, Sim SM, Deyama T, Nishibe S. Vascular effects of Siberian ginseng (Eleutherococcus senticosus): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size. Naunyn Schmiedebergs Arch Pharmacol. 2004;369:473-480.15095033
Laube R, Liu K. An unwanted complement: Rare case of potential liver injury induced by an interaction between ginseng and atorvastatin. Br J Clin Pharmacol. 2019;85(7):1612-1613.30980549
Lewis WH, Zenger VE, Lynch RG. No adaptogen response of mice to ginseng and Eleutherococcus infusions. J Ethnopharmacol. 1983;8:209-2146685799
Li F, Zhang N, Wu Q, et al. Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy. Int J Mol Med. 2017;39(1):199-207.27959392
Lopresti AL, Smith SJ, Drummond PD. Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials. Nutr Neurosci. 2021;2:1-27. doi:10.1080/1028415X.2021.189225333650944
Makarieva TN, Dmitrenok AS, Stonik VA, Patel AV, Canfield LM. Lignans from Eleutherococcus senticosus (Siberian ginseng). Pharm Sci. 1997;3:525-527.
Martinez B, Staba EJ. The physiological effects of Aralia, Panax and Eleutherococcus on exercised rats. Jpn J Pharmacol. 1984;35:79-85.6379247
McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. CMAJ. 1996;155:293-295.8705908
Medon PJ, Ferguson PW, Watson CF. Effects of Eleutherococcus senticosus extracts on hexobarbital metabolism in vivo and in vitro. J Ethnopharmacol. 1984;10:235-241.6727401
Minkova M, Pantev T. Effect of Eleutherococcus extract on the radioprotective action of adeturone. Acta Physiol Pharmacol BuIg. 1987;13:66-70.3448891
Nishibe S, Kinoshita H, Takeda H, Okano G. Phenolic compounds from stem bark of Acanthopanax senticosus and their pharmacological effect in chronic swimming and stressed rats. Chem Pharm Bull. 1990;38:1763-1765.2208394
Panossian A, Brendler T. The role of adaptogens in prophylaxis and treatment of viral respiratory infections. Pharmaceuticals (Basel). 2020;13(9):236.32911682
Panossian A, Seo EJ, Efferth T. Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells. Phytomedicine. 2019;60:152881.30987861
Panossian A, Wagner H. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytother Res. 2005;19:819-838.16261511
Park EJ, Nan JX, Zhao YZ, et al. Water-soluble polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice. Basic Clin Pharmacol Toxicol. 2004;94:298-304.15228502
Pearce PT, Zois I, Wynne KN, Funder JW. Panax ginseng and Eleutherococcus senticosus extracts—in vitro studies on binding to steroid receptors. Endocrinol Jpn. 1982;29:567-573.6303763
Poindexter BJ, Allison AW, Bick RJ, Dasgupta A. Ginseng: Cardiotonic in adult rat cardiomyocytes, cardiotoxic in neonatal rat cardiomyocytes. Life Sci. 2006;79:2337-2344.16945393
Schmidt M, Thomsen M, Kelber O, Kraft K. Myths and facts in herbal medicines: Eleutherococcus senticosus (siberian ginseng) and its contraindication in hypertensive patients. Botanics: Targets and Therapy. 2014;4:27.
Shang SY, Ma YS, Wang SS. Effect of eleutherosides on ventricular late potential with coronary heart disease and myocarditis [in Chinese]. Zhong Xi Yi Jie He Za Zhi. 1991;11:280-281, 261.1879032
Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides. J Am Coll Nutr. 2004;23:248-258.15190050
Solovyeva AG, Petukhova TV, Greshnykh RD. Anaylsis and standardization of Eleutherococcus roots and rhizomes and its liquid extract by the amount of biologically active compounds [in Russian]. Farmatsiia. 1989;38:25-27.
Tian BJ, Gao TL, Song ZL. Effects of ciwujia (Acanthopanax senticosus harms) on reperfusion-induced arrhythmia and action potential alterations in the isolated rat heart [in Chinese]. Zhongguo Zhong Yao Za Zhi. 1989;14:493-495, 508, 512.2508675
Umeyama A, Shoji N, Takei M, Endo K, Arihara S. Ciwujianosides Dl and Cl: powerful inhibitors of histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells. J Pharm Sci. 1992;81:661-662.1383492
Wagner H, Norr H, Winterhoff H. Plant adaptogens. Phytomedicine. 1994;1:63-76.
Wagner H, Wurmbock A. Chemistry, pharmacology and TLC of ginseng and Eleutherococcus drugs [in German]. Dtsch Apoth Ztg. 1977;117:743-748.
Yamauchi Y, Ge YW, Yoshimatsu K, et al. Memory enhancement by oral administration of extract of Eleutherococcus senticosus leaves and active compounds transferred in the brain. Nutrients. 2019;11(5):1142.31121888
Yat P, Arnason JT, Awang DV. An improved extraction procedure for the rapid, quantitative high-performance liquid chromatographic estimation of the main eleutherosides (B and E) in Eleutherococcus senticosus (Eleuthero). Phytochem Anal. 1998;9:291-295.
Yun-Choi HS, Kim JH, Lee JR. Potential inhibitors of platelet aggregation from plant sources, ΙΙΙ. J Nat Prod. 1987;50:1059-1064.3127544
Zhai C, Wang M, Raman V, et al. Eleutherococcus senticosus (Araliaceae) leaf morpho-anatomy, essential oil composition, and its biological activity against Aedes aegypti (Diptera: Culicidae) [published correction appears in J Med Entomol. 2017;54(5):1451]. J Med Entomol. 2017;54(3):658-669.28399215

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