Lupron Depot Injection: Uses, Dosage & Side Effects - Drugs.com

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# Lupron Depot

Generic name: leuprolide [ LOO-proe-lide ]
Brand names: Eligard, Lupron Depot
Drug classes: Gonadotropin releasing hormones, Hormones / antineoplastics

Medically reviewed by Sophia Entringer, PharmD. Last updated on Jun 30, 2022.

## What is Lupron Depot?

Lupron Depot overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily. This medicine reduces the amount of testosterone in men or estrogen in women.

Lupron Depot is used in men to treat the symptoms of prostate cancer (but does not treat the cancer itself).

Lupron Depot is used in women to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids.

Lupron Depot-Ped is used to treat precocious (early-onset) puberty in both male and female children at least 2 years old.

## Warnings

Your symptoms may become temporarily worse when you first start using Lupron Depot. Tell your doctor if this continues for longer than 2 months.

Call your doctor at once if you have a seizure, or unusual changes in mood or behavior.

Lupron Depot can harm an unborn baby or cause birth defects. Do not use if you are pregnant or breastfeeding.

## Before taking this medicine

You should not use Lupron Depot if you are allergic to leuprolide or similar medicines such as buserelin, goserelin, histrelin, nafarelin, or if you have abnormal vaginal bleeding that has not been checked by a doctor.

Lupron Depot can cause birth defects. Do not use if you are pregnant. Tell your doctor right away if you become pregnant.

Certain brands or strengths of leuprolide are used to treat only men and should not be used in women or children. Always check your medicine to make sure you have received the correct brand and strength. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.

To make sure Lupron Depot is safe for you, tell your doctor if you have ever had:

- depression, mental illness or psychosis;

- seizures or epilepsy;

- a blood vessel disorder;

- a brain tumor or spinal cord injury;

- heart disease, congestive heart failure, long QT syndrome;

- an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or

- risk factors for bone loss (personal or family history of osteoporosis, smoking, alcohol use, taking steroid or seizure medicines long term).

Do not give this medicine to any child without medical advice.

Lupron Depot usually causes women to stop ovulating or having menstrual periods. However, you may still be able to get pregnant. Use a condom or diaphragm with spermicide to prevent pregnancy. Lupron Depot can make hormonal birth control less effective (birth control pills, injections, implants, skin patches, vaginal rings).

Call your doctor if your periods continue while you are being treated with this medicine.

You should not breast-feed while using Lupron Depot.

Lupron Depot pregnancy and breastfeeding warnings (more detail)

## How should I use Lupron Depot?

Use Lupron Depot exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Different brands or strengths of leuprolide are used to treat different conditions. It is very important that you receive exactly the brand and strength your doctor has prescribed. Always check your medication to make sure you have received the correct brand and type prescribed by your doctor.

Lupron Depot is injected under the skin or into a muscle, once every month or once every 3 to 6 months. A healthcare provider can teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use Lupron Depot if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

Your symptoms may become temporarily worse as your hormones adjust to leuprolide.

Keep using the medicine as directed, and tell your doctor if your condition is still worse after 2 months of using Lupron Depot.

You may need frequent medical tests while using Lupron Depot.

Store Lupron Depot in the original carton at room temperature, away from moisture and heat. Protect from light.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

## Dosing information

Usual Adult Dose for Endometriosis:

3.75 mg IM once a month for up to 6 months
OR
11.25 mg depot every 3 months
Comments:
-In women receiving this drug for endometriosis, hormone replacement therapy is recommended to reduce bone mineral density loss and vasomotor symptoms.
Uses: Management of endometriosis (including pain relief and reduction of endometriotic lesions), preoperative hematologic improvement of patients with anemia caused by uterine leiomyomata

Usual Adult Dose for Uterine Leiomyomata (Fibroids):

3.75 mg IM once a month for up to 6 months
OR
11.25 mg depot every 3 months
Comments:
-In women receiving this drug for endometriosis, hormone replacement therapy is recommended to reduce bone mineral density loss and vasomotor symptoms.
Uses: Management of endometriosis (including pain relief and reduction of endometriotic lesions), preoperative hematologic improvement of patients with anemia caused by uterine leiomyomata

Detailed Lupron Depot dosage information

## What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

## What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

## What should I avoid while using Lupron Depot?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

## Lupron Depot side effects

Get emergency medical help if you have signs of an allergic reaction to Lupron Depot (hives, sweating, fast heartbeats, dizziness, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

- problems with your pituitary gland - sudden severe headache, vomiting, problems with your eyes or vision, changes in mood or behavior;

- bone pain, loss of movement in any part of your body;

- swelling, rapid weight gain;

- a seizure;

- unusual changes in mood or behavior (crying spells, anger, feeling irritable);

- sudden chest pain or discomfort, wheezing, dry cough or hack;

- painful or difficult urination; or

- high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor.

Rare but serious side effects may occur. Call your doctor if you have:

- pain or unusual sensations in your back, numbness, weakness, or tingly feeling in your legs or feet;

- muscle weakness or loss of use, loss of bowel or bladder control;

- heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or

- signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech.

Common Lupron Depot side effects may include:

- pituitary gland problems;

- cold symptoms such as stuffy nose, sneezing, sore throat, cough with or without mucus;

- fever, tiredness, not feeling well;

- stomach pain, nausea, vomiting, constipation;

- wheezing, chest tightness, trouble breathing;

- hot flashes, sweating;

- dizziness, mood changes;

- headache, general pain;

- vaginal swelling, itching, or discharge;

- weight changes;

- decreased testicle size;

- decreased interest in sex; or

- redness, pain, swelling, or oozing where the shot was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Lupron Depot side effects (more detail)

## What other drugs will affect Lupron Depot?

Lupron Depot can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Other drugs may interact with leuprolide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Lupron Depot drug interactions (more detail)

## Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lupron Depot only for the indication prescribed.

## Popular FAQ

How long should you take it for prostate cancer?

Patients treated with Lupron Depot (leuprolide acetate) for prostate cancer usually continue treatment upon development of castration-resistant prostate cancer, whether it has spread beyond the prostate (metastatic) or not. Continue reading

How do you inject it for prostate cancer?

Lupron Depot (leuprolide acetate) is a depot suspension formulation only injected by your doctor. Lupron Depot is injected into a muscle of your upper arm, upper thigh or buttocks once every month, or once every 3, 4 or 6 months for the treatment of prostate cancer. Depot formulations release medicine continuously over a certain period of time. Continue reading

Is this a chemotherapy treatment?

Lupron Depot (leuprolide acetate) injection is not a chemotherapy treatment, but a prescription hormone medicine used in the palliative treatment of advanced prostate cancer. Palliative treatment is used to relieve pain or other symptoms and improve the quality of your life. Lupron Depot is not a cure for advanced prostate cancer. Continue reading

Does it need to be refrigerated?

Before reconstitution, Lupron Depot for treatment of prostate cancer can be stored in its original container at room temperature (77°F [25°C]), with a range between 59°F to 86°F [15°C to 30°C]). Once Lupron Depot is reconstituted, inject the suspension immediately. Discard if not used within two hours, because Lupron Depot does not contain a preservative. Continue reading

What does this drug do for IVF?

During an vitro fertilization (IVF) protocol, your doctor may use leuprolide (Lupron) injection as part of an ovarian stimulation regimen. Leuprolide is a gonadotrophin-releasing hormone (GnRH) agonist. It reduces the amount of hormone that stimulates ovulation. This helps to control your ovulatory cycle and prevent premature ovulation, so that your doctor can have predictable access to your eggs for IVF. The brand name Lupron is no longer available in the U.S., but generic options are available. Continue reading

Will I get my period while on Lupron?

In clinical studies evaluating endometriosis, 95% of women started their periods (normal menstrual cycle) in the third month after treatment ended with Lupron Depot 3.75 mg. Continue reading

Are Lupron Depot and Eligard the same drug?

Lupron Depot and Eligard are brand name medicines that both contain the active ingredient leuprolide acetate. Both Lupron Depot and Eligard are prescribed to treat the symptoms of advanced prostate cancer. Lupron Depot is also approved to treat endometriosis, uterine fibroids, or central precocious puberty (CPP) in children (early puberty). Continue reading

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## More about Lupron Depot (leuprolide)

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### Patient resources

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#### Other brands

Lupron, Eligard, Camcevi, Viadur

### Professional resources

- Prescribing Information

### Other formulations

- Lupron Depot-Ped

### Related treatment guides

- Prostate Cancer
- Endometriosis
- Uterine Fibroids

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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