Elahere: Uses, Dosage, Side Effects & Warnings

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# Elahere

Generic name: mirvetuximab soravtansine-gynx
Dosage form: injection, for intravenous use
Drug class: Miscellaneous antineoplastics

Medically reviewed by Judith Stewart, BPharm. Last updated on Nov 15, 2022.

## What is Elahere?

Elahere is a prescription medicine used to treat adults with ovarian cancer that has not responded to platinum-based chemotherapy.

Elahere is an antibody-drug conjugate that works by targeting folate receptor-alpha (FRα), a cell-surface protein highly expressed in ovarian cancer.

## What is Elahere used to treat?

Elahere is used to treat folate receptor-alpha positive ovarian cancer, fallopian tube cancer, or primary peritoneal cancer who have not responded to or are no longer responding to treatment with platinum-based chemotherapy, and who have have received 1 to 3 prior types of chemotherapy.

Your healthcare provider will perform a test to make sure that Elahere is right for you.

It is not known if this medicine is safe and effective in children.

## Important information

Elahere can cause serious side effects, including:

- Eye problems. Eye problems are common with Elahere and can also be severe. Tell your healthcare provider right away if you develop any eye problems during treatment, including blurred vision, dry eyes, sensitivity to light, eye pain, or new or worsening vision changes.
  - Your healthcare provider will send you to see an eye care professional to check your eyes before you start, and during treatment, and as needed for any worsening signs and symptoms of eye problems.
  - Your healthcare provider will prescribe steroid eye drops and lubricating eye drops before you start and during your treatment. You should use eye drops as directed by your healthcare provider.
  - Do not wear contact lenses throughout your treatment unless you are told to use them by your healthcare provider.

See Elahere side effects for more information about side effects.

## Before receiving Elahere

Before you receive Elahere, tell your healthcare provider about all of your medical conditions, including if you:

- have vision or eye problems.
- have liver problems.
- are pregnant or plan to become pregnant. Elahere can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment.
  Females who are able to become pregnant:
  - Your healthcare provider should do a pregnancy test before you start treatment.
  - You should use an effective birth control (contraception) during treatment and for 7 months after your last dose.
- are breastfeeding or plan to breastfeed. It is not known if Elahere passes into your breast milk. Do not breastfeed during treatment and for 1 month after your last dose.

## What other drugs will affect Elahere?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking certain other medicines during treatment with Elahere may affect how the medicines work, or cause side effects.

Especially tell your doctor of if you are taking any of the following medicines:

- macrolide antibiotics (clarithromycin, erythromycin)
- antifungal medicines (itraconazole, ketoconazole, posaconazole, voriconazole)
- HIV medicines that contain atazanavir, darunavir, efavirenz, etravirine, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir, or cobicistat
- heart or blood pressure medicines (quinidine, amiodarone, diltiazem, verapamil)
- cimetidine
- mifepristone
- nefazodone

Elahere drug interactions (more detail)

## How will I receive Elahere?

- Elahere will be given to you by infusion into your vein (intravenous or IV).
- Before each dose, you will receive medicines to help prevent infusion related reactions, nausea, and vomiting.
- Elahere is usually given every 3 weeks (21-day cycle). Your healthcare provider will decide how many cycles you need.

## Dosing information

Usual Adult Dose for Ovarian Cancer

6 mg/kg adjusted ideal body weight administered as an intravenous infusion every 3 weeks until disease progression or unacceptable toxicity

Comments:
-Administer as an intravenous infusion only after dilution in 5% Dextrose Injection, USP.
-Premedicate with a corticosteroid, antihistamine, and antipyretic.
-Premedicate with an antiemetic, ophthalmic topical steroids, and lubricating eye drops.

Use:
-treatment of adult patients with FRα positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer, who have received one to three prior systemic treatment regimens. Select patients for therapy based on an FDA-approved test.
This indication is approved under accelerated approval based on tumor response rate and durability of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.

## Elahere side effects

Elahere can cause serious side effects, including:

- See Important information
- Lung problems (pneumonitis). Elahere can cause severe or life-threatening inflammation of the lungs that may lead to death. Tell your healthcare provider right away if you get new or worsening symptoms, including trouble breathing, shortness of breath, cough, or chest pain.
- Peripheral neuropathy. You may develop nerve problems called peripheral neuropathy during treatment. Your healthcare provider will monitor you for signs and symptoms of nerve problems. Tell your healthcare provider if you get new or worsening numbness or tingling in your hands or feet or muscle weakness.

The most common side effects include:

- feeling tired
- increased liver enzymes in the blood
- diarrhea
- decreased albumin level in the blood
- nausea
- stomach-area (abdominal) pain
- decreased red or white blood cell counts
- constipation
- decreased magnesium level in the blood

Your healthcare provider may change your dose, delay treatment, or completely stop treatment if you have certain side effects.

These are not all of the possible side effects of Elahere.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Elahere side effects (more detail)

## General information about the safe and effective use of Elahere.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information that is written for healthcare professionals.

## What are the ingredients in Elahere?

Active ingredient: mirvetuximab soravtansine-gynx
Inactive ingredients: glacial acetic acid, polysorbate 20, sodium acetate, sucrose, Water for Injection.

## References

1. Elahere Product Label

## More about Elahere (mirvetuximab soravtansine)

- Check interactions
- Pricing & coupons
- Drug images
- Side effects
- FDA approval history
- Drug class: miscellaneous antineoplastics
- Breastfeeding

### Patient resources

- Advanced Reading

### Professional resources

- Prescribing Information

### Related treatment guides

- Ovarian Cancer
- Peritoneal Cancer
- Fallopian Tube Cancer

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer