Indomethacin Intravenous Advanced Patient Information - Drugs.com

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# Indomethacin (Intravenous)

Medically reviewed by Drugs.com. Last updated on Jul 16, 2022.

## Commonly used brand name(s)

In the U.S.

- Indocin

Available Dosage Forms:

- Powder for Solution

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Acetic Acid (class)

## Uses for indomethacin

Indomethacin injection is used to treat patent ductus arteriosus (PDA) in premature infants (babies born too early) who weigh between 500 and 1750 grams. PDA is a heart problem where a blood vessel, the ductus arteriosus, fails to close normally after birth. This blood vessel is only used before birth, and is no longer needed after the baby is born. Indomethacin injection works by causing the PDA to constrict, and this closes the blood vessel. Indomethacin is used when other medical treatment for PDA fails after 48 hours.

Indomethacin is available only with your doctor's prescription.

## Before using indomethacin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For indomethacin, the following should be considered:

### Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to indomethacin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

### Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of indomethacin injection in premature babies.

### Geriatric

No information is available on the relationship of age to the effects of indomethacin injection in geriatric patients.

### Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

### Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving indomethacin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using indomethacin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

- Ketorolac

Using indomethacin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

- Abciximab
- Acenocoumarol
- Amiloride
- Amineptine
- Amitriptyline
- Amitriptylinoxide
- Amoxapine
- Anagrelide
- Apixaban
- Ardeparin
- Argatroban
- Aspirin
- Bemiparin
- Bendroflumethiazide
- Benzthiazide
- Betamethasone
- Betrixaban
- Bivalirudin
- Budesonide
- Bumetanide
- Cangrelor
- Certoparin
- Chlorothiazide
- Chlorthalidone
- Cilostazol
- Citalopram
- Clomipramine
- Clopamide
- Clopidogrel
- Cortisone
- Cyclopenthiazide
- Cyclosporine
- Dabigatran Etexilate
- Dalteparin
- Danaparoid
- Deflazacort
- Desipramine
- Desirudin
- Desmopressin
- Desvenlafaxine
- Dexamethasone
- Diazoxide
- Dibenzepin
- Diflunisal
- Digoxin
- Dipyridamole
- Dothiepin
- Doxepin
- Duloxetine
- Edoxaban
- Enoxaparin
- Eplerenone
- Epoprostenol
- Eptifibatide
- Escitalopram
- Ethacrynic Acid
- Feverfew
- Fluocortolone
- Fluoxetine
- Fluvoxamine
- Fondaparinux
- Furosemide
- Ginkgo
- Glucagon
- Gossypol
- Heparin
- Hydrochlorothiazide
- Hydrocortisone
- Hydroflumethiazide
- Ibuprofen
- Iloprost
- Imipramine
- Indapamide
- Inotersen
- Ketoprofen
- Lepirudin
- Levomilnacipran
- Lithium
- Lofepramine
- Lornoxicam
- Loxoprofen
- Lumiracoxib
- Macimorelin
- Magnesium Salicylate
- Meadowsweet
- Meclofenamate
- Mefenamic Acid
- Melitracen
- Meloxicam
- Mesalamine
- Methotrexate
- Methyclothiazide
- Methylprednisolone
- Metolazone
- Milnacipran
- Morniflumate
- Nabumetone
- Nadroparin
- Naproxen
- Nefazodone
- Nepafenac
- Niflumic Acid
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Nortriptyline
- Olsalazine
- Opipramol
- Oxaprozin
- Oxyphenbutazone
- Paramethasone
- Parecoxib
- Parnaparin
- Paroxetine
- Pemetrexed
- Pentosan Polysulfate Sodium
- Pentoxifylline
- Phenindione
- Phenprocoumon
- Phenylbutazone
- Phenyl Salicylate
- Piketoprofen
- Piroxicam
- Polythiazide
- Potassium
- Potassium Citrate
- Prasugrel
- Prednisolone
- Prednisone
- Probenecid
- Proglumetacin
- Propyphenazone
- Proquazone
- Protein C
- Protriptyline
- Reboxetine
- Reviparin
- Rivaroxaban
- Rofecoxib
- Salicylamide
- Salicylic Acid
- Salsalate
- Sertraline
- Sibutramine
- Sodium Salicylate
- Spironolactone
- Sulfasalazine
- Sulindac
- Tacrolimus
- Tenofovir Disoproxil Fumarate
- Tenoxicam
- Tianeptine
- Tiaprofenic Acid
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tirofiban
- Tolfenamic Acid
- Tolmetin
- Torsemide
- Trazodone
- Treprostinil
- Triamterene
- Trichlormethiazide
- Trimipramine
- Trolamine Salicylate
- Valdecoxib
- Vasopressin
- Venlafaxine
- Vilazodone
- Vorapaxar
- Vortioxetine
- Warfarin
- Xipamide

Using indomethacin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

- Acebutolol
- Alacepril
- Atenolol
- Azilsartan
- Azilsartan Medoxomil
- Benazepril
- Betaxolol
- Bisoprolol
- Candesartan
- Captopril
- Carteolol
- Carvedilol
- Celiprolol
- Cilazapril
- Enalapril
- Enalaprilat
- Eprosartan
- Esmolol
- Fosinopril
- Gentamicin
- Irbesartan
- Labetalol
- Levobunolol
- Lisinopril
- Losartan
- Metipranolol
- Metoprolol
- Moexipril
- Nadolol
- Nebivolol
- Olmesartan
- Oxprenolol
- Penbutolol
- Perindopril
- Pindolol
- Practolol
- Propranolol
- Quinapril
- Ramipril
- Sotalol
- Spirapril
- Telmisartan
- Timolol
- Trandolapril
- Valsartan
- Zofenopril

### Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

### Other medical problems

The presence of other medical problems may affect the use of indomethacin. Make sure you tell your doctor if you have any other medical problems, especially:

- Active bleeding (e.g., brain hemorrhage or stomach bleeding) or
- Bleeding problems (e.g., thrombocytopenia) or
- Congenital heart disease or
- Infection, untreated or
- Kidney problem or
- Necrotizing enterocolitis, known or suspected (an inflamed intestine)—Should not be used in babies with these conditions.

- Liver disease—Use with caution. Effects may be increased because of slower removal of the medicine from the body.

## Proper use of indomethacin

A nurse or other trained health professional will give indomethacin to your baby. Indomethacin is given through a needle placed in one of your baby's veins.

Detailed Indomethacin dosage information

## Precautions while using indomethacin

Indomethacin injection may change how the body reacts during an infection. Your baby's doctor will monitor your baby for any signs of infection (e.g., fever, chills, or other unusual behavior).

Indomethacin may affect the action of platelets, which are necessary for clotting the blood. This may increase the chance of bleeding for your baby. Your baby's doctor will monitor your baby for any unusual bleeding or bruising, any dark-colored urine or stools, or other signs of bleeding in your baby.

Indomethacin may decrease your baby's urine volume. This may increase your baby's chance of having kidney problems or low sodium in the blood (hyponatremia). Blood and urine tests will be needed to check for any signs of these risks.

Liver problems may occur while your baby is receiving indomethacin. Stop using indomethacin and check with your baby's doctor right away if your baby is having more than one of these symptoms: abdominal pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

## Indomethacin side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

- Abdominal or stomach pain
- ammonia-like breath odor
- bloody or black, tarry stools
- coma
- confusion
- constipation
- convulsions
- decreased urine output
- difficult breathing
- dizziness
- fast or irregular heartbeat
- headache, sudden, severe
- increased thirst
- irregular heartbeat
- loss of appetite
- muscle pain or cramps
- nausea and vomiting
- nervousness
- numbness or tingling in the hands, feet, or lips
- severe stomach pain
- shortness of breath
- swelling of the face, ankles, or hands
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
- weakness or heaviness of the legs
- weight loss

Less common

- Anxiety
- blurred vision
- chills
- cold sweats
- cool, pale skin
- depression
- full or bloated feeling
- heartburn
- increased hunger
- indigestion
- nightmares
- noisy, rattling breathing
- pressure in the stomach
- seizures
- severe abdominal or stomach pain, cramping, or burning
- severe constipation
- severe vomiting
- shakiness
- slurred speech
- swelling of the abdominal or stomach area
- swelling of the fingers, hands, feet, or lower legs
- troubled breathing at rest
- unusual bruising or bleeding
- vomiting of material that looks like coffee grounds, severe and continuing
- weight gain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Indomethacin side effects (more detail)

## Frequently asked questions

- What is Ardosons called in the U.S?
- Why is my poop green? What does this mean?
- Can I take Tylenol while taking indomethacin and can these drugs be alternated every 3 hours?

View more FAQ

## More about indomethacin

- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (203)
- Drug images
- Latest FDA alerts (6)
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Drug class: Nonsteroidal anti-inflammatory drugs
- Breastfeeding
- En español

### Patient resources

- Drug Information
- Indomethacin (Advanced Reading)
- Indomethacin Rectal (Advanced Reading)
- Indomethacin Capsules
- Indomethacin Extended-Release Capsules
- Indomethacin Suppositories

#### Other brands

Indocin, Indocin SR, Tivorbex

### Professional resources

- Prescribing Information

### Related treatment guides

- Back Pain
- Ankylosing Spondylitis
- Bursitis
- Bartter Syndrome

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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