Telotristat ethyl Uses, Side Effects & Warnings - Drugs.com

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# Telotristat ethyl

Generic name: telotristat ethyl [ tel-OH-tri-stat-ETH-il ]
Brand name: Xermelo
Dosage form: oral tablet (250 mg)
Drug class: Miscellaneous GI agents

Medically reviewed by Drugs.com on Jun 10, 2021. Written by Cerner Multum.

## What is telotristat ethyl?

Telotristat ethyl is used in adults to treat carcinoid syndrome diarrhea, in combination with another medicine such as octreotide (Sandostatin).

Telotristat ethyl may also be used for purposes not listed in this medication guide.

## Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

## Before taking this medicine

Tell your doctor if you have ever had liver disease.

Tell your doctor if you are pregnant or breastfeeding.

Not approved for use by anyone younger than 18 years old.

## How should I take telotristat ethyl?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Telotristat ethyl is usually taken 3 times per day with food.

Telotristat ethyl comes in a monthly case that contains 4 weekly boxes; 1 box of 7 daily doses for use each week. Keep each tablet in the package until you are ready to take a dose.

Octreotide is usually given at least 30 minutes after taking telotristat ethyl.

Telotristat ethyl is only part of a complete treatment program that may also include other medications. Do not change your doses or medication schedule without your doctor's advice.

Store at room temperature away from moisture and heat.

Do not share telotristat ethyl with another person, even if they have the same symptoms you have.

## What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

## What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

## What should I avoid while taking telotristat ethyl?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

## Telotristat ethyl side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Telotristat ethyl may cause serious side effects. Stop using telotristat ethyl and call your doctor at once if you have:

- severe constipation; or

- severe or worsening stomach pain.

Common side effects of telotristat ethyl may include:

- nausea, loss of appetite, gas;

- headache, depressed mood;

- swelling in your hands or feet;

- fever; or

- abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Telotristat side effects (more detail)

## Telotristat ethyl dosing information

Usual Adult Dose for Carcinoid Tumor:

250 mg orally 3 times a day
Comments:
-Patients should take this drug with food.
-If needed, short-acting octreotide should be given at least 30 minutes after administration of this drug.
Use: Treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in patients whose diarrhea is inadequately controlled by SSA therapy

Usual Adult Dose for Carcinoid Syndrome:

250 mg orally 3 times a day
Comments:
-Patients should take this drug with food.
-If needed, short-acting octreotide should be given at least 30 minutes after administration of this drug.
Use: Treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in patients whose diarrhea is inadequately controlled by SSA therapy

Detailed Telotristat dosage information

## What other drugs will affect telotristat ethyl?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect telotristat ethyl, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Telotristat drug interactions (more detail)

## Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

## Popular FAQ

What type of diarrhea does Xermelo treat?

Xermelo (telotristat ethyl) is a tablet used to treat carcinoid syndrome diarrhea. This is a type of diarrhea that develops in people with carcinoid tumors. Continue reading

## More about telotristat

- Check interactions
- Reviews (1)
- Side effects
- Dosage information
- During pregnancy
- Drug class: miscellaneous GI agents
- En español

### Patient resources

- Advanced Reading

#### Other brands

Xermelo

### Professional resources

- Prescribing Information

### Related treatment guides

- Carcinoid Syndrome Diarrhea

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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