Tebentafusp-tebn Intravenous Advanced Patient Information - Drugs.com

Skip to main content
Print
Save

# Tebentafusp-tebn (Intravenous)

Medically reviewed by Drugs.com. Last updated on Oct 5, 2022.

Intravenous route(Solution)

Warning: Cytokine Release SyndromeCytokine Release Syndrome (CRS), which may be serious or life-threatening, occurred in patients receiving tebentafusp-tebn. Monitor for at least 16 hours following first three infusions and then as clinically indicated .

## Commonly used brand name(s)

In the U.S.

- Kimmtrak

Available Dosage Forms:

- Solution

Therapeutic Class: Antineoplastic Agent

## Uses for tebentafusp-tebn

Tebentafusp-tebn injection is used to treat uveal melanoma (eye cancer) that has spread or cannot be removed by surgery in patients who are HLA-A*02:01 positive. Your doctor will perform a test to check for the HLA-A*02:01 gene to make sure tebentafusp-tebn is right for you.

Tebentafusp-tebn is to be given only by or under the direct supervision of your doctor.

## Before using tebentafusp-tebn

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For tebentafusp-tebn, the following should be considered:

### Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to tebentafusp-tebn or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

### Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of tebentafusp-tebn injection in the pediatric population. Safety and efficacy have not been established.

### Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tebentafusp-tebn injection in the elderly.

### Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

### Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

### Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

### Other medical problems

The presence of other medical problems may affect the use of tebentafusp-tebn. Make sure you tell your doctor if you have any other medical problems, especially:

- Liver disease—Use with caution. May make this condition worse.

## Related/similar drugs

Kimmtrak, tebentafusp

## Proper use of tebentafusp-tebn

Medicines used to treat cancer are very strong and can have many unwanted effects. Before receiving tebentafusp-tebn, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

A nurse or other trained health professional will give you tebentafusp-tebn in a medical facility. It is given through a needle placed into one of your veins. The medicine must be given slowly, so the needle will have to remain in place for at least 15 to 20 minutes. The injection is usually given every week.

Your doctor will check you closely for at least 16 hours after receiving the first 3 treatments and for at least 30 minutes after future treatments with tebentafusp-tebn.

Detailed Tebentafusp dosage information

## Precautions while using tebentafusp-tebn

It is very important that your doctor check your progress at regular visits to make sure that tebentafusp-tebn is working properly. Blood tests may be needed to check for unwanted effects.

Receiving tebentafusp-tebn while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using tebentafusp-tebn to make sure you are not pregnant. Use an effective form of birth control to keep from getting pregnant during treatment with tebentafusp-tebn and for at least 1 week after the last dose. If you think you have become pregnant while receiving the medicine, tell your doctor right away.

Tebentafusp-tebn may cause cytokine release syndrome (CRS), which may be life-threatening and requires immediate attention. Tell your doctor right away if you have fever, chills, headache, nausea, lightheadedness, dizziness, fainting, skin rash, trouble breathing, or tiredness or weakness.

Tebentafusp-tebn may cause skin reactions. Check with your doctor right away if you have a rash, itching, or swelling of the skin.

Check with your doctor right away if you have dark urine, clay-colored stools, stomach pain, or yellow eyes or skin. These may be symptoms of a serious liver problem.

## Tebentafusp-tebn side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

- Blurred vision
- chills
- confusion
- diarrhea
- dizziness
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- faintness
- fast, pounding, or irregular heartbeat or pulse
- feeling of warmth
- fever
- general feeling of discomfort or illness
- headache
- muscle or joint pain
- nausea
- nervousness
- pounding in the ears
- rash, itching, or skin swelling
- redness of the face, neck, arms and occasionally, upper chest
- redness of the skin
- sweating
- unusual tiredness or weakness
- unusually warm skin
- vomiting

Rare

- Anxiety
- chest pain
- clay colored stools
- cough
- dark urine
- loss of appetite
- problems with movement, walking, or speech
- seizures
- stomach pain or tenderness
- swelling of the feet or lower legs
- trouble breathing
- yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

- Back pain
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- constipation
- difficulty in moving
- dry skin
- joint pain or swelling
- lightening of the normal skin color
- loss or thinning of the hair
- muscle aches, cramps, pain, or stiffness
- night sweats
- pain in the arms or legs
- runny nose
- shivering
- sore throat
- trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tebentafusp side effects (more detail)

## More about tebentafusp

- Side effects
- Dosage information
- During pregnancy
- Drug class: miscellaneous antineoplastics
- En español

### Patient resources

- Drug Information

#### Other brands

Kimmtrak

### Professional resources

- Prescribing Information

### Related treatment guides

- Uveal Melanoma

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer