Cipro HC Advanced Patient Information - Drugs.com

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# Cipro HC (Otic)

Generic name: ciprofloxacin and hydrocortisone (otic route) [ sip-roe-FLOX-a-sin-hye-droe-KLOR-ide, hye-droe-KOR-ti-sone ]
Drug class: Otic steroids with anti-infectives

Medically reviewed by Drugs.com. Last updated on Oct 1, 2022.

## Commonly used brand name(s)

In the U.S.

- Cipro HC

In Canada

- Cipro Hc

Available Dosage Forms:

- Suspension

Therapeutic Class: Anti-Infective/Anti-Inflammatory Combination

Pharmacologic Class: Adrenal Glucocorticoid

Chemical Class: Ciprofloxacin

## Uses for Cipro HC

Ciprofloxacin and hydrocortisone is a combination medicine used to treat otitis externa. Otitis externa, also known as Swimmer's ear, is an infection of the outer ear canal caused by bacteria. The ear canal and outer part of the ear may be swollen, red, and painful.

Ciprofloxacin belongs to the class of medicines known as fluoroquinolone antibiotics. It works by killing the bacteria or preventing their growth. Hydrocortisone is a corticosteroid (cortisone-like medicine) that is used to relieve the redness, itching, and swelling caused by ear infections.

This medicine is available only with your doctor's prescription.

## Before using Cipro HC

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

### Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

### Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ciprofloxacin and hydrocortisone combination in children.

### Geriatric

No information is available on the relationship of age to the effects of ciprofloxacin and hydrocortisone combination in geriatric patients.

### Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

- Agomelatine
- Bepridil
- Cisapride
- Desmopressin
- Dronedarone
- Eliglustat
- Flibanserin
- Levoketoconazole
- Mesoridazine
- Pimozide
- Piperaquine
- Rotavirus Vaccine, Live
- Saquinavir
- Sparfloxacin
- Terfenadine
- Thioridazine
- Tizanidine
- Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

- Abametapir
- Acalabrutinib
- Acarbose
- Acecainide
- Aceclofenac
- Acemetacin
- Albiglutide
- Aldesleukin
- Alfentanil
- Alfuzosin
- Alogliptin
- Alosetron
- Alprazolam
- Amiodarone
- Amisulpride
- Amitriptyline
- Amoxapine
- Amtolmetin Guacil
- Anagrelide
- Apomorphine
- Aripiprazole
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Artemether
- Asenapine
- Astemizole
- Avapritinib
- Azimilide
- Azithromycin
- Balofloxacin
- Bemiparin
- Bendamustine
- Benzhydrocodone
- Besifloxacin
- Betamethasone
- Bosutinib
- Bretylium
- Brigatinib
- Bromfenac
- Budesonide
- Bufexamac
- Buprenorphine
- Bupropion
- Buserelin
- Canagliflozin
- Celecoxib
- Ceritinib
- Chlorpromazine
- Chlorpropamide
- Cholera Vaccine, Live
- Choline Salicylate
- Cilostazol
- Ciprofloxacin
- Citalopram
- Clarithromycin
- Clofazimine
- Clomipramine
- Clonixin
- Clothiapine
- Clozapine
- Cobicistat
- Codeine
- Conivaptan
- Corticotropin
- Cortisone
- Cosyntropin
- Crizotinib
- Cyclobenzaprine
- Dabrafenib
- Dapagliflozin
- Daridorexant
- Dasatinib
- Deflazacort
- Degarelix
- Delamanid
- Desipramine
- Deslorelin
- Deutetrabenazine
- Dexamethasone
- Dexibuprofen
- Dexketoprofen
- Dexmedetomidine
- Diclofenac
- Diflunisal
- Dihydrocodeine
- Dipyrone
- Disopyramide
- Dofetilide
- Dolasetron
- Domperidone
- Donepezil
- Doxorubicin
- Doxorubicin Hydrochloride Liposome
- Droperidol
- Droxicam
- Dulaglutide
- Duloxetine
- Efavirenz
- Empagliflozin
- Encorafenib
- Enoxacin
- Entrectinib
- Erlotinib
- Ertugliflozin
- Erythromycin
- Escitalopram
- Etodolac
- Etofenamate
- Etoricoxib
- Exenatide
- Fedratinib
- Felbinac
- Fenfluramine
- Fenoprofen
- Fentanyl
- Fepradinol
- Feprazone
- Fexinidazole
- Finerenone
- Fingolimod
- Flecainide
- Fleroxacin
- Floctafenine
- Fluconazole
- Fludrocortisone
- Flufenamic Acid
- Flumequine
- Fluocortolone
- Fluoxetine
- Flurbiprofen
- Formoterol
- Foscarnet
- Fosnetupitant
- Fostemsavir
- Gatifloxacin
- Gemifloxacin
- Glasdegib
- Glimepiride
- Glipizide
- Glyburide
- Gonadorelin
- Goserelin
- Granisetron
- Halofantrine
- Haloperidol
- Histrelin
- Hydrocodone
- Hydrocortisone
- Hydroxychloroquine
- Hydroxyzine
- Ibrutinib
- Ibuprofen
- Ibutilide
- Ifosfamide
- Iloperidone
- Imipramine
- Indomethacin
- Infigratinib
- Inotuzumab Ozogamicin
- Insulin
- Insulin Aspart, Recombinant
- Insulin Bovine
- Insulin Degludec
- Insulin Detemir
- Insulin Glulisine
- Insulin Lispro, Recombinant
- Ivosidenib
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lapatinib
- Larotrectinib
- Lefamulin
- Leflunomide
- Lemborexant
- Lenvatinib
- Leuprolide
- Levofloxacin
- Linagliptin
- Liraglutide
- Lixisenatide
- Lofexidine
- Lomefloxacin
- Lopinavir
- Lornoxicam
- Loxoprofen
- Lumateperone
- Lumefantrine
- Lumiracoxib
- Lurasidone
- Lurbinectedin
- Lutetium Lu 177 Dotatate
- Macimorelin
- Magnesium Sulfate
- Mavacamten
- Meclofenamate
- Mefenamic Acid
- Mefloquine
- Meloxicam
- Meperidine
- Metformin
- Methadone
- Methylprednisolone
- Metronidazole
- Midazolam
- Mifepristone
- Miglitol
- Mirtazapine
- Mitapivat
- Mobocertinib
- Moricizine
- Morniflumate
- Moxifloxacin
- Mycophenolate Mofetil
- Nabumetone
- Nadifloxacin
- Nadroparin
- Nafarelin
- Naloxegol
- Naproxen
- Nateglinide
- Nepafenac
- Netupitant
- Niflumic Acid
- Nilotinib
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Nitisinone
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olaparib
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxaprozin
- Oxycodone
- Oxyphenbutazone
- Ozanimod
- Pacritinib
- Paliperidone
- Panobinostat
- Parecoxib
- Pasireotide
- Pazopanib
- Pazufloxacin
- Pefloxacin
- Pemigatinib
- Pentazocine
- Pexidartinib
- Phenylbutazone
- Piketoprofen
- Pimavanserin
- Pioglitazone
- Pirfenidone
- Piroxicam
- Pitolisant
- Pomalidomide
- Ponesimod
- Porfimer
- Posaconazole
- Pramlintide
- Pranoprofen
- Prednisolone
- Prednisone
- Procainamide
- Prochlorperazine
- Proglumetacin
- Promethazine
- Propafenone
- Propyphenazone
- Proquazone
- Protriptyline
- Prulifloxacin
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Rasagiline
- Repaglinide
- Ribociclib
- Rimegepant
- Rofecoxib
- Rosiglitazone
- Rufloxacin
- Salicylic Acid
- Salsalate
- Sargramostim
- Saxagliptin
- Selpercatinib
- Selumetinib
- Semaglutide
- Sematilide
- Sertraline
- Sevoflurane
- Simeprevir
- Simvastatin
- Siponimod
- Sirolimus Protein-Bound
- Sitagliptin
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Sodium Salicylate
- Solifenacin
- Sonidegib
- Sorafenib
- Sotalol
- Sparfloxacin
- Sufentanil
- Sulindac
- Sulpiride
- Sunitinib
- Tacrolimus
- Tasimelteon
- Tazemetostat
- Tedisamil
- Telavancin
- Telithromycin
- Tenoxicam
- Teriflunomide
- Tetrabenazine
- Theophylline
- Tiaprofenic Acid
- Tolazamide
- Tolbutamide
- Tolfenamic Acid
- Tolmetin
- Tolvaptan
- Toremifene
- Tosufloxacin
- Tramadol
- Trazodone
- Triamcinolone
- Triclabendazole
- Trifluoperazine
- Trimipramine
- Triptorelin
- Ubrogepant
- Valdecoxib
- Vandetanib
- Vardenafil
- Vemurafenib
- Venetoclax
- Venlafaxine
- Vilanterol
- Vinflunine
- Voclosporin
- Voglibose
- Voriconazole
- Warfarin
- Zanubrutinib
- Zolpidem
- Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

- Aceclofenac
- Alcuronium
- Aminolevulinic Acid
- Amlodipine
- Atracurium
- Auranofin
- Chloroquine
- Colestipol
- Cyclosporine
- Diclofenac
- Dutasteride
- Fosphenytoin
- Gallamine
- Hexafluorenium
- Itraconazole
- Lanthanum Carbonate
- Licorice
- Metocurine
- Phenytoin
- Primidone
- Probenecid
- Rifapentine
- Ropinirole
- Ropivacaine
- Saiboku-To
- Sildenafil
- Suvorexant

### Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

- Caffeine

### Other medical problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

- Viral ear infections (e.g., varicella or herpes simplex)—Should not be used in patients with these conditions.

## Proper use of Cipro HC

This medicine is to be used only in the ear. Do not use it in the eyes and do not take it by mouth. If this medicine is accidently swallowed, call your doctor right away.

It is important that the infected ear remains clean and dry. When bathing, avoid getting the infected ear wet. Avoid swimming unless your doctor has instructed you otherwise.

To use the ear drops:

- Wash your hands thoroughly with soap and water.
- Hold the bottle in your hands for 1 or 2 minutes to warm up the solution before putting it in your ear. Putting a cold solution in your ear could cause you to become dizzy.
- Shake the bottle well.
- Lie down on your side with your infected ear facing up.
- Put the drops in the infected ear. You should remain on your side for at least one minute.
- Repeat the above steps if both ears are infected.

To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the ear). Also, keep the container tightly closed.

Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon. Do not miss any doses.

### Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

- For ear drops dosage form:
  - For ear infections:
    - Adults and children above 1 year of age—Place 3 drops in the affected ear two times a day.
    - Children younger than 1 year of age—Use and dose must be determined by your doctor.

### Missed dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

### Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Cipro HC dosage information

## Precautions while using Cipro HC

If your symptoms do not improve, or if they become worse, check with your doctor.

This medicine may cause serious allergic reactions including anaphylaxis, which can be life-threatening and require immediate medical attention. Stop using this medicine and call your doctor right away if you have itching; hives; hoarseness; rash; shortness of breath; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth.

## Cipro HC side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

- Blistering, crusting, irritation, itching, or reddening of the skin
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- cracked, dry, or scaly skin
- hives or welts
- itching
- redness of the skin
- skin rash
- swelling

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

- Headache

Incidence not known

- Cough
- hair loss or thinning of hair
- headache, severe and throbbing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Cipro HC side effects (more detail)

## More about Cipro HC (ciprofloxacin / hydrocortisone otic)

- Compare alternatives
- Pricing & coupons
- Reviews (1)
- Side effects
- Dosage information
- During pregnancy
- Drug class: otic steroids with anti-infectives
- En español

### Patient resources

- Drug Information
- Cipro HC

### Professional resources

- Prescribing Information

### Other formulations

- Cipro
- Cipro I.V. injection
- Cipro XR

### Related treatment guides

- Acute Otitis Externa

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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