Vyndaqel Uses, Side Effects & Warnings - Drugs.com

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# Vyndaqel

Generic name: tafamidis [ ta-FAM-id-is ]
Brand names: Vyndamax, Vyndaqel
Drug class: Transthyretin stabilizers

Medically reviewed by Drugs.com on Aug 29, 2022. Written by Cerner Multum.

## What is Vyndaqel?

Vyndaqel affects a protein called transthyretin (TTR, made primarily in the liver). Transthyretin-mediated amyloidosis (ATTR) is a condition in which abnormal deposits of TTR protein build-up in many parts of the body, interfering with normal function. A build-up of TTR in the heart can lead to heart failure.

People with hereditary ATTR amyloidosis have a DNA mutation that can be passed from one generation to the next. People with wild-type ATTR amyloidosis do not have abnormal DNA and cannot pass on the condition.

Vyndaqel is used in adults with hereditary or wild type ATTR to treat cardiomyopathy (damage of the heart muscle) caused by a build-up of TTR.

Vyndaqel may also be used for purposes not listed in this medication guide.

## Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

## Before taking this medicine

Tell your doctor if you have ever had:

- liver disease.

Your name may be listed on a Transthyretin Amyloidosis Outcome Survey registry to track the effects of tafamidis on your condition.

Vyndaqel may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

If you become pregnant, tell your doctor or contact the manufacturer of tafamidis at 1-800-438-1985.

You should not breastfeed while using Vyndaqel.

## Related/similar drugs

Vyndamax, tafamidis, Amvuttra, Onpattro, inotersen, patisiran

## How should I take Vyndaqel?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Vyndaqel and Vyndamax are not equivalent medicines and may not have the same dosing schedule.

Take either Vyndaqel or Vyndamax exactly as your doctor has recommended. Avoid medication errors by using only the form and strength your doctor prescribes.

Swallow the capsule whole and do not crush, chew, break, or open it.

You may take Vyndaqel with or without food.

Store at room temperature away from moisture and heat. Keep each capsule in the blister pack until you are ready to take a dose.

Detailed Vyndaqel dosage information

## What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

## What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

## What should I avoid while taking Vyndaqel?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

## Vyndaqel side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Vyndaqel side effects (more detail)

## What other drugs will affect Vyndaqel?

Other drugs may affect Vyndaqel, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Vyndaqel drug interactions (more detail)

## Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

## Popular FAQ

What’s the difference between Vyndaqel and Vyndamax?

The difference between Vyndaqel and Vyndamax lies in the form of tafamidis, their active ingredient, that they contain.

Vyndaqel contains the micronized meglumine salt of tafamidis, while Vyndamax contains the free acid form of tafamidis.

Vyndamax was developed for patient convenience and this formulation allows patients to take just one capsule once per day. Patients taking Vyndaqel, on the other hand, need to take four capsules once a day. Continue reading

How does Vyndaqel work for ATTR-CM?

Vyndaqel works in ATTR-CM (cardiomyopathy of transthyretin-mediated amyloidosis) by binding to and stabilizing the transthyretin (TTR) transport protein. This slows down the production of amyloid deposits in the heart that lead to ATTR-CM.

Continue reading

How long does it take Vyndamax to work?

Vyndamax, when compared to a placebo, was shown to improve the survival rates (71% vs. 57%, respectively) for patients with wild-type or hereditary transthyretin-mediated amyloidosis (ATTR-CM) over a 30-month long clinical study. Quality-of-life measurements improved as early as 6 months. Continue reading

How long does it take for Vyndaqel to start working?

It takes at least 6 months for Vyndaqel to start working and it may take up to 18 months for the full effects to be seen, but these persist for at least 30 months. There was significantly less decline in functional capacity (as measured by a 6-minute walk test [6MWT]) and health status (as measured by the Kansas City Cardiomyopathy Questionnaire-Overall Summary [KCCQ-OS]) with Vyndaqel at 6 months than placebo. It may take at least 18 months before Vyndaqel makes a difference in all cause mortality compared to placebo, but this difference persists and trials have reported a survival rate of 71% in those taking Vyndaqel compared to 57% taking placebo. Those receiving Vyndaqel had 32% less hospitalizations due to heart problems, also statistically significant. Continue reading

## More about Vyndaqel (tafamidis)

- Check interactions
- Pricing & coupons
- Imprints, shape & color data
- Side effects
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: transthyretin stabilizers
- En español

### Patient resources

- Advanced Reading

#### Other brands

Vyndamax

### Professional resources

- Prescribing Information

### Related treatment guides

- Amyloid Cardiomyopathy
- Amyloidogenic Transthyretin Amyloidosis

## Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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