Total clearance of paliperidone was reduced in subjects with impaired renal function by 32% in mild (Creatinine Clearance [Cr Cl] = 50 to < 80 ml/ min), 64% in moderate (CrCl = 30 to < 50 ml/ min), and 71% in severe (CrCl = < 30 ml/ min) renal impairment.
A paliperidon teljes clearance- e 32% - kal csökkent az enyhe (kreatinin- clearance [CrCl] = 50 - < 80 ml/ perc), 64% - kal a közepes fokú (CrCl = 30 - < 50 ml/ perc), 71% - kal a súlyos (CrCl = < 30 ml/ perc) vesekárosodásban szenvedő betegeknél.