Gravely concerned that, despite continued increased efforts by States, relevant international organizations, civil society and non-governmental organizations, the drug problem is still a challenge of a global dimension, which constitutes a serious threat to the health, safety and well-being of all mankind, in particular young people, in all countries, undermines development, including efforts to reduce poverty, socio-economic and political stability and democratic institutions, entails an increasing economic cost for Governments, also threatens the national security and sovereignty of States, as well as the dignity and hope of millions of people and their families, and causes irreparable loss of human lives,
严重关切各国、有关国际组织、民间社会和非政府组织虽继续加紧努力，但毒品问题仍然是一项全球性的挑战，严重威胁全人类，特别是各国青年的健康、安全和福祉，破坏发展，包括减轻贫穷的努力，危及社会经济和政治稳定以及民主体制，使各国政府付出不断增加的经济代价，还威胁到各国的国家安全和主权以及千千万万人民及其家庭的尊严和希望，造成无法挽回的人命损失，