A recent trial in non diabetic nephropathies found that combined RAS inhibition with ARBs and ACE inhibitors decreases progression to ESRD by 50% as compared to ARB or ACE inhibition alone. Evidence that combined therapy more effectively than ACE inhibitor or ARB therapy alone reduces albuminuria or proteinuria in patients with type 2 diabetes, suggests that a similar renoprotective effect could be achieved also in overt nephropathy of type 2 diabetes. Indeed, short-term proteinuria reduction is a strong predictor of slower progression of renal disease and reduced cardiovascular mortality in the long term.