2.8.4. Discontinuation/Withdrawal of Participants from Study Treatment Each participant had the right to withdraw from the study at any time. The investigator would withdraw a participant if the participant had blood transfusion or a fall in Hb to less than 7g/dL or a macroscopic haemoglobinuria or a fall in Hb by >25% (within the first 14 days or 8 weeks, as above) or significant protocol deviation, disease progression, lost of follow up, use of drugs with antimalarial activity, an important adverse event or an emergency event.