I. To compare response rate, time to response, duration of response, toxicity, and survival in the two regimens (vincristine sulfate, carmustine, melphalan, cyclophosphamide, prednisone [VBMCP] vs. VBMCP alternating with high-dose cyclophosphamide and then with recombinant interferon alfa-2b [r alpha2b-IFN]) in patients with previously untreated multiple myeloma.