CRP values were measured on two different point-of-care CRP devices in 100 children and compared with the laboratory CRP results in hospitalised children and children consulting an outpatient paediatric clinic of a university hospital. To verify whether the devices were user-friendly and reliable, a CRP measurement was performed on children and adults attending in 5 General Practice surgeries by 2 different Point-of-Care CRP devices. The inter-device (by 1 physician) and inter-observer (by two physicians) variability was tested on 10 patients in one GP surgery each on two different POC devices of the same brand.