Background and Rationale (Treatment of warfarin associated coagulopathy) Other than simply withholding warfarin and allowing the INR to fall to the desired range, two "active" approaches are used to lower the INR in excessively anticoagulated patients. Transfusion of coagulation factor concentrates replaces missing coagulation factors. Supplemental vitamin K antagonizes the effect of warfarin, thus increasing endogenous synthesis of these same factors.