A lot has been speculated about the systemic absorption of Bevacizumab. In a study at the Bascom Palmer Eye Institute, doctors Rosenfeld, Puliafito et al demonstrated the effectiveness of the systemic application of Bevacizumab for the treatment of the age related macular degeneration applying dose of 5mg/Kg. thus Demonstrating, the passage of the molecule from the systemic circulation to specific tissue in both eyes(10). Recently, doctor Bakri and her team at Mayo Clinic in Rochester, Minnesota, establish that a small portion of intravitreal bevacizumab is able to pass to the systemic circulation (1.6% of the injected dose) obtaining detectable concentrations in the vitreous of the fellow eye (11.17ng/ml) at week number 4 after the treatment (21). In the same way, we have cases in our hospital, reported like anecdotal cases, of Bevacizumab application in one eye and improvement of the base pathology in the fellow eye.