This is a single arm, open label, phase II drug study. This study will be conducted at the Breast Care Center at Baylor College of Medicine and its affiliated hospital, and at Ben Taub General Hospital in Houston. Patients who were diagnosed with CNS metastases (brain +/- leptomeningeal disease) will be identified prospectively. All eligible patients will receive capecitabine concurrently with WBRT followed by combination capecitabine with sunitinib. WBRT will be administered at 30 Gy in 10 fractions together with capecitabine to be given on the first day of WBRT at 1000 mg/m2/day and continued daily for 14 days. After a 7 days rest period, capecitabine will be restarted at 2000mg/m2/day for 14 days followed by a 7 days rest period. This will be given together with sunitinib at 37.5 mg daily. This is the dosing determined by the phase I study with capecitabine and sunitinib. Dose reduction and/or treatment postponement will be done for significant toxicity. Capecitabine with sunitinib will be administered until disease progression in either CNS and/or non-CNS sites. Efficacy assessments will be performed on all subjects via imaging studies in the CNS and extra-CNS sites 8 weeks after starting study, then every 12 weekly. Neurological examination will be performed at baseline, 3 weeks after starting treatment, then every 6 weekly. Assessment of treatment toxicity will be performed at baseline, 3 weeks after starting treatment, then every 3 weekly using the NCI Common Toxicity grading system. Clinical and laboratory parameters will be assessed until disease progression or withdrawal from study (due to unacceptable toxicity or withdrawal of consent). Subjects with progression of CNS and / or extra-CNS disease will be considered progressors. Subjects withdrawn from treatment will be followed for survival until death.