Previous experiment in remnant kidney model also showed that adrenalectomy with adequate glucocorticoid replacement reduced the proteinuria and other evidence of renal injury usually seen in REM rats. Similarly heparin administration provides remarkably complete protection from injury in remnant kidney model. Although this effect could be due to any of several actions of heparin (anticoagulant and hemodynamic), it could be due to known suppressive action of heparin on aldosterone synthesis.