8. The initial HFO mPaw will exceed the mPaw of the preceding CΜV by 8-10 cm H2O and will be titrated (by ±3 cmH2O) to the best oxygenation response (predicted to correspond to a "target" SaO2 of >= 95%) during a 60-min period of standard, low frequency HFO with cuff leak. The aforementioned period will precede the below-described 180-min period of HFO strategy testing.