-DOCK8 deficiency patients with 10/10 matched related donors and unrelated donors will receive a pre-transplant conditioning regimen consisting of fludarabine 40 mg/m2/day on days -6, -5, -4, and -3, and busulfan 3.2 mg/kg IV every day for 4 days on days -6, -5, -4, and -3. The busulfan dosing will be adjusted based upon a test dose of busulfan given prior to the start of the conditioning regimen. Donor hematopoietic stem cells will be infused on day 0.