Paclitaxel is a mitotic inhibitor and another antiproliferative agent and widely used, effective agent in drug eluting stents to reduce restenosis in coronary circulation. Paclitaxel binds specifically to the beta-tubulin subunit of microtubules and appears to antagonize the disassembly of this key cytoskeletal protein; this action results in accumulation of microtubule bundles and aberrant microtubular derived structures in the mitotic phase of the cell cycle. Zilver PTX (Cook Medical) paclitaxel-eluting stent is designed for the SFA. It is a nitinol stent coated with paclitaxel only, with no polymer or binder. A recent prospective, randomized trial reported significantly better 24-month event-free survival among patient receiving PTX stent than among those treated with PTA (86,6% vs. 77.6%, p<0.01). Primary patency at 24 months of the PTX stent group was 74.8% vs 32.4% for the PTA group. (Dake , LINC 2011).