Several phase II trials have investigated the efficacy and safety of Gemcitabine as a single agent, second-line therapy. Table below summarizes the results of the phase II trials.These trials concluded that gemcitabine has a modest activity as second-line chemotherapy for NSCLC. It has the advantage to be well tolerated and may thus be one drug to be proposed to the patients who have disease progression after a first-line chemotherapy and who ask for further treatment.