Null hypotheses H0: Mean reduction of proviral DNA < 1 log. Alternative hypotheses H1: Mean reduction of proviral DNA ≥1 log Level of significance : 0.05 Statistical test: One-tailed paired t-test MUC_NewEra_v3.3 Protocol: EudraCT: 2008-002070-35 date: 6.11.2014 page 27 The null hypotheses will be rejected if the p-value of the test is less than the significance level (0.05).