The principal goal of ovulation induction in infertile patients with regular menstrual cycles is to achieve two to three mature synchronous follicles to maximize chance of pregnancy and minimize risk of ovarian hyperstimulation syndrome. Poor responders, by definition, have a lower likelihood of sufficient follicular recruitment. Lesser recruitment can be compounded by follicular dysynchrony that necessitates human chorionic gonadotropin (hCG) administration based on larger follicles when lagging smaller follicles are less likely to be mature. Follicular dysynchrony can be compounded by the rise in follicle stimulating hormone (FSH) in the luteal phase.