The investigators plan to use Macugen [TM] to treat 30 patients with ischaemic DME. The investigators will diagnose macular ischaemia by assessing the size of the foveal avascular zone (FAZ). This is the area at the centre of the macula. It is usually devoid of blood vessels in order to maximise visual clarity. The FAZ may be abnormally enlarged and irregular in patients with diabetes and this is a requirement for the diagnosis of ischaemic DME. Enlargement of the FAZ is thought to be a sign of reduced blood flow, possibly related to the effects of VEGF, and is associated with reduced vision. Macugen [TM] will be given at the standard dose that is used for treating AMD and that which was identified as most effective in the phase 2 study of Macugen [TM] in DME, i.e. 0.3mg. Our primary outcome will be the change in size of the FAZ and secondarily we would like to look for a change in thickness of the retina at the centre of the macula or a change in visual acuity. The investigators hope that this pilot study will clarify whether Macugen [TM] might be able to reverse some of the effects of VEGF(165) and be of benefit for those with ischaemic DME, the more severe end of the DME spectrum.