Further understanding of the mechanism of hypoxic pulmonary vasoconstriction will aid in prognosis and treatment in conditions of increased pulmonary vascular resistance such as congenital heart disease, pulmonary arterial hypertension, and COPD, in addition to high-altitude pulmonary hypertension and high-altitude pulmonary edema (HAPE). Furthermore, the current treatment modalities for HAPE have demonstrated variable and/or limited effectiveness, so riociguat could potentially be used to prevent or treat HAPE in susceptible individuals. Additionally, riociguat could substantially improve exercise performance in those who must operate in conditions of high-altitude, such as those conducting military operations or working in high-altitude rescue teams.