The grant was renewed in 1994 through November 1998 to conduct a new study entitled Modifiers of Myocardial Infarction Onset (Modifiers Study) . The Modifiers Study elucidated the pathophysiology of acute myocardial infarction (Ml) onset and utilized the methodologic techniques, 50-hospital national study group, and findings of the completed NHLBl-funded Determinants of Myocardial Infarction Onset Study (Determinants Study). The Modifiers Study identified factors that increased or decreased the susceptibility of patients to the triggers of acute Ml previously identified.