A mixed effects model of repeated measure will be used to compare the changes in cognition and clinical symptoms among the three groups. With mixed effects model, all available data of each subject at each time point will be used (R. Gueorguieva & J. H. Krystal, 2004). This strategy was based on the assumption that data were missing at random (Ralitza Gueorguieva & John H Krystal, 2004).With the unstructured covariance structure (Joe et al., 2009), differences between the three intervention groups over time were assessed with a Group x Time interaction term. Primary outcome measures (HKLLT, Digit Span test, Letter Cancellation test) will be first analyzed by including all three groups. For analyses meeting this criterion of statistical significance, follow-up, the priori comparisons of the active intervention groups with the waitlist group were carried out with the same strategy. All tests will be based on two-sided probabilities set at a significance level of 0.05. The Bonferroni correction procedure will be conducted to adjust for the multiple comparisons among groups.The effect size (Cohen's d) will be calculated as well to compare the therapeutic effects of yoga and aerobic exercise among the three groups.