CED improves chemotherapeutic delivery to brain tumors intraparenchymally by utilizing bulk flow, or fluid convection, established as a result of a pressure gradient, rather than a concentration gradient. As such, CED offers markedly improved distribution of infused therapeutics within the central nervous system (CNS) compared to direct injection or via drug eluting polymers, both of which depend on diffusion for parenchymal distribution. Additionally, CED obviates the challenges of systemic agents crossing the blood brain barrier while minimizing systemic exposure and toxicity. Through the maintenance of a pressure gradient from the delivery cannula tip to the surrounding tissues, CED is able to distribute small and large molecules, including high molecular weight proteins, to clinically significant target volumes centimeters rather than millimeters in diameter. Although developed independently, work combining the two delivery options, liposomes and CED, is presently underway in an effort to improve treatment efficacy in the treatment of CNS malignancies. This clinical trial is a step in this direction with a prospective, single-arm, open-label trial that delivers liposomal-irinotecan and gadolinium (which provided real time imaging of delivery) by CED in patients with recurrent malignant glioma.