- Subjects in Groups A to G and Groups I to K will be males of any ethnic origin between 18 and 55 years of age and with a body mass index (BMI) between 18 and 31 kg/m2 inclusive. Subjects in Groups H and L will be females of any ethnic origin between 18 and 65 years of age and with a body mass index (BMI) between 18 and 31 kg/m2 inclusive. All subjects will have a body weight greater than 50 kg. For Group H, women will be of non-childbearing potential, defined as follows: Female subjects 50 years of age or less must be surgically sterile or post-menopausal (defined as at least two years post cessation of menses and/or follicular stimulating hormone >18 mIU/mL and serum oestradiol <110 pmol/L), non-lactating and have a negative serum pregnancy test Female subjects of more than 51 years of age must be surgically sterile or post-menopausal (defined by a value of follicular stimulating hormone >18 mIU/mL and no spontaneous menstruation for at least one year before the first dose), non-lactating and have a negative serum pregnancy test.