Independent of whether a hypermethylated locus is specific for overt cancer (Type I) or not (Type II), it would be of interest for the study. These Type II changes would be "hypothesis generating". Since it has been well documented in the literature that DNA from cells can be shed into the blood stream (more so in the case of cancer patients), it would be expected that at least for some of the loci that are hypermethylated (Type I and II), this methylation would be detectable in the plasma. Tumor tissue methylation will be correlated with serum obtained at the time of tumor resection.