Fibrin formation at the site of laser-induced injury was significantly more important (P<0,01) in mice following injection of Panc02-High TF in comparison with wild type mice. Treatment of these mice by Clopidogrel diminished the production of fibrin at a level comparable to the ones observed in wild type mice. When the pathological TF was shut down, production of fibrin was strongly reduced in comparison with both the group of mice injected by Panc02 cells and the group of wild type mice. the investigators conclude that when cancer cells and cancer cell-derived microparticles express active TF, their incorporation to a growing thrombus participates to the generation of a thrombotic phenotype. When TF expressed by cancer cells is shut down, cancer cells microparticles still incorporate at the site of thrombus formation, but reduces activation of TF, inhibiting fibrin generation and thrombus formation by bringing TFPI at the site of injury.