Premature ovarian failure (POF) is defined as hypergonadotropic ovarian failure occurring prior to age 40 . It is surprisingly common and affects approximately 1% of women below the age of 40. The incidence is 10% to 28% in women with primary amenorrhea and 4% to 18% in women with secondary amenorrhea . The clinical manifestations include amenorrhea and abnormally high levels of luteinizing (LH) and follicle stimulating hormone (FSH). The etiology of POF is unknown in most cases. It can be caused by combination of inherited conditions, immune disorders, environmental toxins and iatrogenic injury. The majority of patients with POF are considered to have idiopathic premature ovarian failure because usually no cause can be identified . POF has been shown to be associated with an increased incidence of other conditions, including Alzheimer's, cardiovascular and immune system diseases, metabolic syndrome, osteoporosis, diabetes and cancer of reproductive organs. POF is characterized by loss of secondary follicles, arrested folliculogenesis, decreased estrogen production, and infertility . The mechanism of ovarian failure is most likely accelerated follicular atresia but detailed pathogenesis is yet to be fully understood .