This study will last 14 weeks. Adult patients, who are non-diabetic or tightly controlled diabetic, and, who have chronic venous leg ulcers, that are not infected and have been open/not healed for at least 12 weeks, will be enrolled in this study. Patients will be recruited from the OSU Wexner Medical Center Comprehensive Wound Center (CWC). On days 0, 14 and 28, patients will have the following performed: measurements and photographs taken of their wound; TCOM (transcutaneous oxygen measurement) or ABI to measure the amount of oxygen in the wound tissue; and two 3-mm punch biopsies from the same wound/ulcer. Biopsies will not be taken if the wound has closed by day 14 or day 28. Additionally, patients' medical records will be reviewed throughout the study to obtain information about the patient (age, sex, race/ethnicity, current medications, TCOM, would location and type, other illness/diagnoses, wound care treatment and instructions, nutritional status based on albumin levels), and at 14 weeks after enrollment to determine the final status of the wound (healed or not healed).