If you are found to be eligible to participate in this study, you will begin taking the study drugs. You will be given two 35-day cycles of bortezomib and rituximab. Bortezomib will be given through a needle in a vein over 3-5 seconds on Days 1, 8, 15, and 22. Rituximab will also be given through a vein on Days 8 and 22. The first rituximab infusion (by vein) usually takes 6-8 hours. Later infusions are generally shorter, taking about 4 hours to complete. While you are receiving bortezomib/rituximab (for 2-3 months), valacyclovir (an anti-viral drug) is taken by mouth, once a day.