More recently there has been even more compelling science indicating that one should consider DNA repair as an Achilles heel in pancreatic cancer. A team led by Nurse Practitioner Gayle Jameson recently reported on the phase Ib/II trial of the combination of paclitaxel protein-bound plus gemcitabine plus cisplatin. In 24 evaluable patients with stage IV pancreatic cancer they reported a response rate of 71% (Complete Response (CR) + Partial Response (PR)) along with a 88% disease control rate (CR + PR+ Stable Disease (SD) at 9 weeks). Utilizing this highly active therapy in the neoadjuvant setting may lead to further improvement in overall survival and progression free survival in patients with pancreatic cancer.