N-acetylcysteine (NAC) is a precursor of reduced GSH. It is an acetylated form of amino acid L-cysteine, and is an excellent source of sulfhydryl groups. It is converted in the body into metabolites capable of stimulating GSH synthesis, promoting detoxification, and acting directly as free radical scavengers. It has been used clinically for more than 30 years primarily as a monolithic. It is now commonly used for pre-treatment to prevent renal injury secondary to intravenous dye in patients with renal insufficiency. It is also a mainstay of treatment in cases of acetaminophen overdose since the 1980s. In this time period, NAC has been shown to be safe without any significant toxicity or side-effects.18 Other studies have shown that NAC can prevent apoptosis and promote cell survival. It reduces endothelial dysfunction, inflammation, fibrosis, cartilage erosion, and transplant prolongation.19 It has also been useful in improving ischemia-reperfusion related liver injury, cocaine and methanol related liver injury.20-23