These randomized, double-masked, placebo-controlled trials will test the hypotheses that supplementation with antioxidant vitamins and with low-dose aspirin reduces the risk of age-related cataract and AMD. The study populations are the Women's Health Study (WHS) and the Women's Antioxidant Cardiovascular Study (WACS). The WHS is a randomized, double-masked, placebo-controlled trial using a 2x2 factorial design to test low-dose aspirin (100 mg on alternate days) and vitamin E (600 IU on alternate days) in the primary prevention of cardiovascular disease (CVD) and cancer. It is being conducted among 39,876 apparently healthy female health professionals age 45 years and older. The WACS is a randomized, double-masked, placebo-controlled secondary prevention trial using a 2x2x2x2 factorial design to test antioxidant vitamins (vitamins E [600 IU on alternate days] and C [500 mg daily], beta carotene [50 mg on alternate days]), and a combination of folate (800 mg daily), vitamin B6 (25 mg daily), and vitamin B12 (1 mg daily) among women who are at high risk for CVD morbidity and mortality. It is being conducted among 8,171 female health professionals, ages 40 years or older, who either have preexisting CVD or have at least three coronary risk factors and therefore are at high risk for the development of CVD.