The study tested the hypothesis that prescribing exercise in multiple short bouts would improve long-term exercise adherence and long-term weight loss, and that the addition of home exercise equipment would further improve these outcomes. A total of 148 overweight women were recruited and randomized to one of three treatments: 1) long-bout exercise; 2) short-bout exercise; 3) short- bout exercise + home exercise equipment. All subjects participated in an 18-month behavioral weight loss program, in which body weight was assessed at 0, 6, 12, and 18 months and exercise adherence was assessed throughout the 18 months. Cardiorespiratory fitness and cardiovascular disease risk factors were measured at 0, 6, and 18 months.