Rammohan et al 25 noted that 200mg/day of Modafinil significantly improved symptoms of fatigue in an MS sample and was tolerated quite well.25 Given that Modafinil has been proven to be a safe, effective treatment of arousal and fatigue, and its neurochemical effects are likely to enhance cognition, we are seeking to apply this medication for the treatment of cognitive deficits in MS. Due to the fact that Modafinil has been shown to act on glutamate and aspartate receptors, specifically influencing the hippocampus, it is hypothesized that treatment with this medication will result in better performance in tests of new learning and memory in an MS sample.