Similar to EIH induced by aerobic exercise, the relationship of anaerobic exercise with hypoalgesia indicates a common mechanism that may be related to the augmentation of the central and peripheral nervous system through modulation of descending inhibition as well as the release of pain-relieving substances. There is possibly an orchestra of overlying and inter-related physiologic, social and psychologic mechanisms that contribute to hypoalgesia response to exercise. Because of confounding effect of various processes of all of these possible processes, it is important to evaluate specific exercise regimens that may provide most pain relief within the context of clinical practice. Although there is good evidence that long-duration aerobic, and high-intensity exercises modulate pain, these strategies may be difficult to apply in a clinical setting due to the disabling nature of painful conditions. Patients with such conditions may be more apt to comply with shorter duration exercises at lesser intensity. No studies to date have specifically addressed differences in pain response when comparing the EIH following anaerobic exercises using concentric and isometric training bouts as well as to a non-exercising control condition. Investigation of EIH in this study will improve understanding of nociceptive changes following therapeutic exercises in a clinical setting.