The main investigator of the trial is professor Hannu Manninen, Kuopio University Hospital. The other investigators in KUH are M.Ds. Kimmo Mäkinen, Petri Saari, and Jussi Kärkkäinen. The main investigator in Helsinki, Oulu, Tampere, and Turku University Hospitals are Jukka Perälä, Kimmo Lappalainen, Janne Korhonen, and Riitta Rautio, correspondingly. Randomization is performed centralized by a study coordinator (Marja-Liisa Sutinen, Kuopio) Analysis of imaging studies is performed in a core lab. The trial will possibly be monitored, which will be performed by an authorized person and coordinated by the research unit of Kuopio University Hospital.