During Part B of the study, 3 participants will be given the same dose of the study drug. If all 3 participants tolerate the dose of study drug well, another 3 participants will enrolled at a higher dose. These dose increases will continue until tumor biopsies show that the drug is having the required effect on the cancer in all 3 participants at 1 dose (this is called the optimal biologic dose, or OBD). However, if 2 participants at 1 dose experience the same intolerable side effect, additional participants will be enrolled at slightly lower doses until the highest well tolerated dose is identified (this is called the maximum tolerated dose, or MTD) this will be the maximum tolerated dose (MTD). Once the MTD or OBD is found, Part C will begin.