These new imaging techniques have a theoretical advantage which is extendedly used for sales purposes but has however so far not been proven in ulcerative colitis patients. We want to test their clinical use in the screening for neoplastic lesions in patients with long standing ulcerative colitis. The scientific and clinical relevance of this study is clear. If NBI and/or FICE and/or I-scan have a better detection rate than chromo-endoscopy, the latter can be replaced by virtual chromo-endoscopy. Even if the detection by NBI and/or FICE and/or I-scan is not statistically different from standard chromo-endoscopy, they still can replace the latter because it is technically easier to use. If however these techniques have a lower adenoma detection rate than classical chromo-endoscopy we will be able to show that there is no place for these techniques in the detection of UC related neoplasia, despite the theoretical advantage.