Consequently, it is estimated that a sample of 45 patients per group would achieve a power of 80% (type II error = 0.2) to detect a medium-to-large effect size of d = 0.6 as regards the primary outcome measures. This effect size is selected as it may be considered a clinically relevant difference to seek. The test statistic used is the two-sided t test and significance is targeted at the 95% confidence level (type I error = 0.05).