When correction of the potential causative factors for delirium fails to reverse delirium, clinicians frequently turn to antipsychotic therapy. (21) Haloperidol remains the first-line pharmacologic therapy for the treatment of delirium by critical care clinicians and is advocated for use in this population by practice guidelines. (14, 22) One large retrospective cohort analysis, where potential confounding variables were addressed, found that use of haloperidol within 2 days of mechanical ventilation reduced death. (23)