Overall, investigations on folic acid supplementation with small groups of FRAX participants have yielded inconsistent findings, with favorable behavioral and/or biochemical effects for some but not others. Moreover, the findings cannot be generalized to the broader population of children with AD who do not have FRAX. Our search of the literature uncovered only one report of folic acid treatment prescribed for 2 children without FRAX, one of whom was described as psychotic with mental retardation and the other, as having a diagnosis of autism. For both children, behaviors were notably improved with treatment and returned to problematic levels when folic acid therapy stopped.