Recent studies suggest that stem cell therapy holds promise in treatment of variety of diseases including reproductive dysfunction. In a recent investigation by our lab, bone marrow stem cell (BMSC) treated animals revealed recovered ovarian function. Post bone marrow nucleated cell transplantation, treated animals revealed resumption of estrogen production and folliculogenesis . In another investigation by Lui et al (2014), granulosa cell apoptosis induced by cisplatin was reduced when BMSCs were migrated to granulosa cells in vitro. In this study, chemotherapy-induced POF rats were injected with BMSCs. The BMSCs treatment group's antral follicle count and estradiol levels increased after 30 days, compared with untreated POF group . In a recent clinical trial in Egypt, Edessy et al evaluated the therapeutic potential of autologous mesenchymal bone marrow stem cells transplantation in women with POF. Ten patients with POF were selected and their ovaries were injected with autologous BMSC via laparoscopy. The results revealed resumption of menstruation in one case after 3 months; two cases showed focal secretory changes after having atrophic endometrium . According to these results, BMSC seem to have the ability to revive prematurely failed ovaries both in its hormonal and follicular development abilities.