Thus, whether dual more than single drug RAS blockade reduces the need for renal replacement therapy in high risk patients with type 2 diabetes and whether ACE inhibitors shear with ARBs a similar or even superior beneficial effect in this typology of patients is worth investigating. This could be of clinical relevance in these terms: 1. Effective prevention of ESRD in people with type 2 diabetes is expected to translate in a remarkable reduction in costs for renal replacement therapy by chronic dialysis or kidney transplantation; 2. A better definition of the cost/effectiveness profile of different study treatments may help optimizing the allocation of available resources in order to achieve more effective prevention at lower costs. 3. The definition of individual risk profiles may allows identifying subjects at increased risk that may benefit the most of intensified treatment, which should translate in a further optimization of the use of available resources at population level. Moreover, in addition to verify whether dual RAS blockade by combined ACE inhibitor and ARB treatment more effectively than single drug RAS blockade may prevent progression to ESRD, the present study will offer the opportunity to compare the renoprotective effects of equivalent doses of ACE inhibitors or ARBs.