Before the beginning of the study and in accordance with the local regulation followed, the protocol and all corresponding documents will be declared for Ethical and Research approval by the Council of OB/GYN Department, Ain Shams University. Furthermore, the approval of the study protocol will be granted by Ethics Research Committee (ERC), Faculty of Medicine, Ain Shams University (ASU), with presentation of patient's information leaflet, consent form, and case record data form (CRF).