In addition to clinical care, all subjects will complete a diagnostic work up which will take approximately 4 hours and include diagnostic, functional, cognitive and physical assessments including routine blood and urine tests. Then weekly visits/contacts for up to one (1) hour in duration for at least eight (8) weeks, then monthly follow-up visits of up to one (1) hour. Brief clinical assessments and self-report questionnaires will be completed at these visits and further blood tests every six months will be required along with weight, waist/hip circumference, blood pressure and pulse rate. Additional blood tests may be required as clinically indicated.