A retrospective study collected clinical information and plasma samples of 117 patients with pancreatic or biliary cancer, of which 68% were pancreatic cancer and 29% biliary cancers. Thrombotic events occurred in 52 (44.4%) patients. Mean and median tissue factor for all patients were 2.15 pg/mL and 1.20 pg/mL, respectively (range: 0.17-31.01 pg/mL). Elevated Tissue Factor levels were significantly associated with VTE events (P=0.04), and an elevated tissue Factor level was associated with a worse overall survival (hazard ratio, HR: 1.05; P=0.01).