No formal analyses will be performed. All data collected for each subject will be incorporated into a narrative of the subject's medical events during the follow-up period. The narrative will recreate the clinical course and evolution of disease history for the subjects and allow assessment for evidence of residual or new adverse events potentially related to their exposure to GSK2248761. Listings of AEs will be generated for each subject. Data on AEs collected quarterly will be combined with the subject's demographic and medical history details in the listing reports. The listings will be delivered to GSK every six months in coordination with the safety advisory committee meetings.