3. Men or nonpregnant women age 35 to 75 years. Women of childbearing potential must have a negative human chorionic gonadotropin (HCG) test result immediately before (within 48 hours) catheter and pump implantation and repeated again immediately before (within 48 hours) the start of drug infusion; men and women of childbearing potential must practice adequate contraception during the course of the study.