Information Working site of designer performs hundreds of the above given operations which a presumption for completion of the study aims. Especially young surgeon will participate in this study who will manage methodology of hospital care as well as surgery under supervision of experienced physician and will educated for patients´ monitoring. Statistical evaluation will be performed by professional statistician. Principle investigator has numerous experiences with clinical studies and she/she published his/her results in journals. Other specific equipment is not necessary for study procedure.