Clinics or health care facilities collaborating with CDRCC will approach their patients to participate in this cohort. Research staff from UTSW or staff at these clinics (or health care facilities) who have received training on how to obtain informed consent will then ask interested patients to sign the IRB-approved Informed Consent and HIPAA authorization documents. Initially, the Informed Consent and HIPAA authorization will be documented on paper, and these documents will be scanned and stored in the master log of the Cohort database in addition to securely storing the paper copy. In the future, patients will be asked to complete Informed Consent and HIPAA authorization documents using computers or handheld electronic devices (including signatures). Paper documents will be made available to those who prefer and request them. Staff from CDRCC will be available either in person, by email, or by phone to answer any questions that arise during the informed consent process that cannot be answered by clinic staff. If patients are under the age of 18, they will provide assent, and a parent or LAR will provide consent. The CDRCC will also develop materials in print and electronic format to publicize the UTSW Depression Cohort. Other patients or healthy individuals who are not involved with a CDRCC collaborator can also join the registry if they complete the informed consent process. The UTSW Depression Cohort will include comprehensive information collected as part of routine care by the patient's provider(s). During routine care at their medical providers' offices, patients may fill out screening questionnaires and self-rated behavioral health assessments, provide medical and psychiatric history, undergo laboratory tests, electrocardiogram (EKG), radiologic or other clinically relevant investigations and be given treatment recommendations. Some of the self-rated assessments completed as part of measurement based care may include Patient Health Questionnaire 2 (PHQ-2), Patient Health Questionnaire 9 (PHQ-9), Patient Adherence Questionnaire (PAQ), Frequency, Intensity, and Burden of Side Effects Rating (FIBSER), Generalized Anxiety Disorder 7 (GAD-7), Concise Associated Symptoms Tracking - Self-Report Scale (CAST-SR), Pain Frequency, Intensity, and Burden Scale (P-FIBS), Concise Health Risk Tracking Scale (CHRT), and Alcohol and Drug usage screen. The information in the Cohort database will be stored indefinitely unless a participant requests the principal investigator to remove his/her name and associated information.