Duloxetine, a new dual action drug, has shown promising efficacy with an early onset of action and a high remission rate both in short- and long-term treatment. Thus, Raskin found an impressive remission rate of 50.8% after six weeks and 81.8% after 52 weeks of treatment. The primary objective of the present study is to examine whether the combination of duloxetine and chronotherapeutic methods induces higher remission rates at an earlier time point and obtains a 50% percent remission rate after three weeks of treatment.