Principle investigator will apply the created protocol and will continuously control its compliance including schedule, will process interim data, will evaluate data compliance with literature and will prepare their presentation and publication and will process final results. 2nd co-worker is guarantees the microbiological part of the project; 3rd and 4th co-workers will collect rather large amount of data and will enter them in created system. 5th and 6th co-workers will control including appropriate patients in study (it means acute procedure), % of included patients out of number of suitable patients is an important criterion for significance of gathered data. They also cooperate in presentation data processing. 7th co-worker controls correctness of data collection. 5 specifically educated independent nurses who do not attend the patient (24 hour service) will prepare infusions for patients according to acquired randomization data - placebo or monitored group. Administrative worker will select data from the information system and patients´ files, file and selects study cards and supervises their correct completion.