- Measurements on blood and 24h urine samples. Plasma, serum and urine samples will be divided into aliquots and stored (-20/-80°C) at the bio-bank of the Studies Coordinating Centre (SCC). Routine measurements include hemoglobin, hematocrit, red and white blood cell counts, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, differential white blood cells count, serum creatinine, uric acid, serum lipids (total, HDL-cholesterol), glycaemia and insulin. Measurements of metabolic, inflammatory and oxidative stress include: 8-hydroxy -2'-deoxyguanosine (8-OHdG), interleukin-6 and high sensitivity C-reactive protein[Pearson et al.]. Other measurements will be considered if enough samples are available (e.g. homeostasis model assessment index (HOMA)[Marcelis et al.], leptin, adiponectin [Marcelis et al., Yeon et al.], E-selectin, P-selectin, vascular adhesion molecule-1, plasma fibrinogen, tumor necrosis factor, superoxide dismutase or serum malondialdehyde[Rao et al., Sharma et al.]).