Preparation of urine and plasma sample collected at the 30th, 65th day (21 days later after cranberry juice/placebo consumption) will follow established protocols. UHPLC (Ultra high-performance liquid chromatography) -Q-Orbitrap-HRMS (High-resolution mass spectrometry) analyses, Multivariate data processing and statistical analysis will be the same as the experiment process discussed in Specific aim 2.