HSC, mononuclear cells, and gran collection from patients with PID may be used for laboratory research or may be designated for future clinical treatment of the patient under separate treatment protocol. HSC collections from healthy sibling/related donor of those patients with PID in need of an allogeneic stem cell transplant will be designated for clinical treatment of the related patient. HSC, mononuclear cells, and gran collection from healthy volunteers will be designated entirely for laboratory research.