A Phase I trial demonstrated that docetaxel could be administered weekly at a maximum tolerated dose of 43 mg/m2/week, with fatigue and asthenia as the dose-limiting toxicities (Hainsworth JD et al 1998). At a weekly dose of 36 mg/m2, docetaxel was extremely well tolerated, with no significant myelosuppression and only occasional NCIC-CTG Grade 3 or 4 non-hematologic toxicities. The recommended dose was 36 mg/m2.