Materials and methods This double-blind, placebo-controlled, randomized (1:1 ratio) controlled trial with two parallel arms involved 48 patients with advanced adult periodontitis. They were recruited at the periodontology department of the Cukurova university, Turkey. All patients referred for periodontal treatment were screened for eligibility.The project was approved by the ethical committee for clinical trials of the Cukurova University in Turkey with number . No changes in the trial design were made after approval by the Ethical Committee.