The generalized leakage of fluid from tiny blood vessels ("capillary hyperpermeability") seen in DME has been described as being somewhat analogous to the leakage or "hyperpermeability" seen from the abnormal blood vessels (choroidal neovascularisation) associated with AMD. [10] Therapeutic effects from blockade of the VEGF(165) isoform previously demonstrated in AMD have been demonstrated in DME. That particular study, detailed below, did not specify the degree of macular ischaemia that these patients had.