All patients should be premedicated prior to paclitaxel or docetaxel administration in order to prevent severe hypersensitivity reactions (HSR). Such premedication may consist of: dexamethasone 20 mg orally administered approximately 12 and 6 hours before paclitaxel or docetaxel; diphenhydramine 50 mg intravenously and cimetidine (300 mg) or ranitidine (50 mg) intravenously 30 minutes before paclitaxel. In case of pemetrexed, patient will received an injection of vitamin B-12 1,000 mcg IM a week prior to start therapy as well as folic acid 1 mg po daily a week before pemetrexed infusion and during the entire course of treatment with this antifolate agent.