- Imaging will be correlated with histology of resected or biopsied lymph nodes when available. Occasionally, patients may not undergo biopsy or surgical excision of their lymph nodes. This may occur if their lymph nodes are overtly large and therefore highly likely to represent lymph node involvement. In such cases, patients will be evaluated with clinical follow up which typically occurs every three months in most NCI protocols. If the lesion demonstrates growth or regression based on RECIST 1.1 criteria on these follow up studies then the lesion will be considered positive for tumor. If it is stable for at least one year then it will be considered non-malignant. The MR imaging analysis will be intra-patient.