Intervention study - Enrolment procedure The study will be explained to women as a group before each day's ANC activities begin. In order not to interfere with the routine ANC activities women who may want to be recruited will then proceed to the study team after their routine ANC care. After obtaining informed consent, socio-demographic information, an obstetric history including previous ANC attendances during current pregnancy, a history of any illness in the past week, and information on bed net use will be collected. Gestational age will be obtained from the ANC card as assessed by the midwife. Anthropometric indices measured will be weight, height and mid-upperarm circumference. The blood pressure and axillary temperature will also be measured. Fingerstick blood sample will be drawn for haemoglobin testing, malaria thick blood smear and filter paper samples, after which each woman will be assessed for eligibility. Subjects will be randomized individually to receive the study drugs. The code on the envelope will be written on all the study forms and samples. The subject's name, address and date of first dosing will be noted on the envelope, to ensure that each woman receives the right regimen over the three-day period and also during subsequent doses of IPTp. To ensure compliance, all doses will be supervised either at the health facility, or through home visits (on Days 1 and 2). Women will receive between one and three doses of the drugs, depending on gestational age at recruitment, thus women recruited at 16 - 19 weeks will receive three doses, those recruited at 20 -26 weeks, two doses and those recruited from 27 -32weeks, one dose. The interval between dosing schedules will be 8 weeks, however the minimum interval allowed will be 4 weeks.