Recently, it has been proven for experimental pneumococcal meningitis that daptomycin leads to a substantially reduced inflammatory reaction compared to ceftriaxone. Additionally, it has been shown that compared to ceftriaxone monotherapy, daptomycin plus ceftriaxone lowers the levels of pro-inflammatory mediators in the cerebrospinal fluid (CSF) and reduces brain damage in the form of hippocampal apoptosis and hearing loss in infant rat pneumococcal meningitis.