Randomization. As soon as possible, but always within 48 hours of admission, participants will be randomly assigned (1:1) to receive either standard care or the intervention using offsite-independent randomization protocols (www.randomization.com). Randomization will be stratified according to presence or absence of sepsis and the availability of a biopsy at baseline. Concealed allocation will be performed using sequentially numbered opaque sealed envelopes only accessible by research personnel with no involvement in the trial.