Calculating sample size phase 2 The sample size was calculated to detect a difference of 2100 mg / dl * min. of glucose AUC measured between 0 and 120 minutes after an oral glucose load in the group treated with LibramedR and the placebo group, with 90% power and 5% alpha error. The mean and standard deviation of the AUC glucose placebo arm were taken from our internal database of 100 patients who performed a glucose tolerance curve and the arm's standard deviation with LibramedR was supposedly equal to that of the other arm.