Studies have shown that patients with SCH suffer from increased arterial stiffness and endothelial dysfunction. One of the non invasive techniques to evaluate arterial stiffness is pulse wave analysis (PWA). PWA gives information of blood pressure at the aortic site rather than more peripherally. Recently, calculated AIx was suggested as an independent risk marker for cardiovascular adverse events. Obuobie et al. analyzed the pressure wave velocity in 12 patients with overt hypothyroidism treated with levothyroxine. They concluded that hypothyroid patients treated with levothyroxine had a decrease in their arterial stiffness after treatment, although no difference in the lipid profile was found.