2.1.7. 'Rescue treatment' If a patient develops signs of severe malaria, parenteral artesunate and parenteral quinine will be given in standard doses [9]. The combination is safe, and would be expected to be effective in case of high level artemisinin resistance [11]. If the patient has a less than 75% fall in parasitaemia by day 3 or has any persisting parasitaemia by day 7, he/she will require rescue treatment consisting of artesunate 6 mg/kg in combination with doxycycline 4 mg/kg for 7 days. In children below the age of 8, doxycycline should be replaced by clindamycin (10 mg/kg/dose, two times a day for 7 days)