1.3 Adverse Drug Reaction (ADR) Reports 1.31 Any life threatening and/or unexpected and serious (grade 3 or 4) toxicity will be reported within 48 hours to the principal investigator: Li-Tzong Chen M.D. Cancer Clinical Research Center, National Health Research Institutes, A191 Ward Veteran General Hospital Taipei, 201, Shih-Pai Road, Sec 2, Taipei 112, Taiwan Tel:886-2-8712121-2737; Fax: 886-2-8716467; and/or Per-Jei Chen, M.D., Ph.D. Department of Internal Medicine, National Taiwan University Liver Disease Research Center, National Taiwan University Hospital. Tel: 886-2-3970800-7072 Fax: 886-2-3317624. The initial contact should be made by calling the Coordinate Center of TCOG,at 886-2-7852459. A written report will follow within 7 working days.