Sleep is instrumental to many aspects of physical and emotional health during childhood and adolescence. Sleep disruption from pain is a significant concern in patients with sickle cell disease due to the prevalence of their acute and chronic pain.[7] In a study conducted by Daniel et al., sickle cell patients between 4-10 years old, were more likely to exhibit disrupted sleep, specifically night-waking and sleep-disordered breathing, than children who were not diagnosed with sickle cell disease from similar demographic backgrounds. [7] Furthermore, children with more severe forms of sickle cell disease were reported to have more restless sleep than children with less severe forms. [7] Overall, the literature suggests that sleep disruptions may interfere with children's daily functions, along with their ability to cope with SCD and its complications.[7] Daniel et al. recommends discussing ways to improve sleep habits with children suffering from SCD because it may increase efficacy in pain management, priapism, and enuresis.[7] Another study by Valrie etal., suggests that poor quality of sleep is correlated with increased occurrence of sickle cell disease pain the following day.[9] They also discovered that high pain severity was related to poor sleep quality and this relationship was exacerbated during stressful situations.[9] Developing a suitable sleeping environment (e.g. removing the television, or limiting the lighting) will maximize sleep efficacy resulting in better health outcomes and quality of life.[7] There has been minimal research on evaluating the relationship between exercise and sickle cell disease in children and adolescents. Studies conducted on sickle cell disease in adults with respect to the effects of exercise have produced mixed results partly due to patient comorbid illnesses. In 2012, Chirico et al. compared two fitness level group including, subjects who did not partake in regular physical activity for two years prior to the study versus subjects who partook in regular, weekly physical activity for several years leading up to the study. [5] Both groups contained sickle cell trait carriers and subjects with normal hemoglobin. [5] Subjects performed an incremental maximum exercise test while data was collected on heart rate via a chest monitor and on oxidative stress levels via blood samples at various points following completion of the exercise task. [5] Results indicated regular physical activity helped to blunt the increase in oxidative stress and the decrease in nitric oxide metabolism and up regulation of antioxidant enzyme activities in response to exercise in sickle cell trait carriers. [5] These findings suggest an attenuated sickle cell crisis in the subjects with regular exercise when compared with the sedentary group.