PEG 3350's safety and efficacy has been documented in multiple studies on children undergoing colonoscopy (15, 16). A recent single arm feasibility study described in a letter to the editor in the American Journal of Gastroenterology 2008 found the use of Miralax (PEG 3350) as colonoscopic preparation to be tolerable and safe in adults (17). Moreover the study reported high compliance. It included 29 patients who underwent screening colonoscopy with PEG 3350 in 64 oz of Gatorade® (The Gatorade Company, Chicago, IL). A "good prep" was described in 97% of cases; patient rated tolerance was good in 86%. Insomnia was the most common adverse effect. Of note, 18 patients had prior 4L PEG bowel cleansing experiences- of these, 50% reported PEG 3350 was better tolerated. Beyond this data, these investigators at a community center (Urbana, IL) have a 3 year exclusive experience with PEG 3350 as their colon preparation; they report anecdotally better patient tolerance and compliance over prior preparations. The inclusion of Gatorade® is to reduce the potential for electrolyte disturbances.