Cigarette smoking is now a leading cause of morbidity and mortality among people living with HIV (PLWH) engaged in highly active antiretroviral therapy (HAART) [2-5]. Between 40-70% of PLWH in the U.S. currently smoke [6-14], in comparison to 20.6% of the general population [15], and tobacco accounted for nearly 25% of all deaths in a multinational cohort of PLWH who used HAART [2]. PLWH who smoke are uniquely vulnerable, moreso than smokers without HIV, to developing cardiovascular [2, 16] and lung [2, 17] diseases, and also are at greater risk than non-smoking PLWH for a multitude of HIV-associated illnesses [3, 5, 18, 19]. Against this backdrop, HIV treatment providers acknowledge the importance of assisting PLWH with smoking cessation, but a significant proportion of them lack confidence, training, and/or time [10, 12, 20]. Very little research on smoking cessation interventions for PLWH has been published, and none has evaluated approaches that could be easily disseminated and integrated into standard HIV care. In this context, a sophisticated, efficacious [ORs, 1.4-1.6 in meta-analyses [21, 22]] tobacco quitline network is now available in every U.S. state via a national quitline portal, 1-800-QUIT-NOW and represents an untapped resource for PLWH. Notably, the most positive findings, to date, for smoking cessation in PLWH have involved telephone counseling delivered by clinical research staff [1], but no existing studies have reported on the efficacy of engaging PLWH with tobacco quitlines or on brief motivational approaches to facilitate this process.