After which, measurements including HR, NiBP, SpO2, RR will be recorded every 5 minutes while Numerical Rating Scale of anxiety every 15 minutes. Sedation is evaluated by investigator using Observer Assessment of Alertness/ Sedation (OAA/S]) scale every 15 minutes. Both the investigators and the subjects are blinded to the study medications. The patient will be shown 2 cards of picture about 1 hour after the study drug administration.