The Salmeterol± Corticosteroids (SLIC) study examined the addition of a long acting beta-agonist, salmeterol, on a scheduled basis for patients with moderate asthma whose symptoms were sub-optimally controlled by using an inhaled beta-agonist on an "as needed" basis and an inhaled corticosteroid on a scheduled basis. The study determined if the addition of salmeterol on a scheduled basis permitted a reduction in dose, and/or elimination of inhaled corticosteroids over time, without a concomitant increase in asthmatic symptoms or a decrease in the bronchoprotective effect to aerosolized methacholine. Recruitment of randomized patients with moderate asthma began in January 1997. Additional patients were randomized at the Harlem Center, a center added to the network in December 1995. The enrollment of 175 patients ended in July 1998 and the last patient visits were completed in January 1999. Results have been published.