Neubauer and colleagues [16] showed that the anti-VEGF drug Avastin [TM], which inhibits all isoforms of VEGF, caused a reduction in peripheral retinal ischaemia and an improvement in visual acuity in patients with diabetic retinopathy. They investigated changes in central and peripheral ischaemia after intravitreal injection of Avastin [TM] and were able to demonstrate in a small series of patients with DR that Avastin [TM] treatment improved peripheral ischaemia in the short term. They saw no evidence of increasing ischaemia, as might be feared. Limitations of their study include the small number of patients and short follow-up after only one administration. They believe that the observed reduction of ischaemia makes anti-VEGF therapy a promising approach in the treatment of DR, but further investigations with longer follow-up times are needed.