Inflammatory disorders, including but not limited to those caused by viral, bacterial, fungal, and parasitic infections, and those associated with aberrant immunologic responses are exceedingly common acute and chronic disorders affecting humans. The pathogenesis of these various disorders are being investigated under a number of NIAID clinical research protocols. This protocol is an evaluation and long-term follow protocol of such disorders for the purposes of maintaining a group of patients on which LCID investigators draw for our other various protocols. The patients admitted under this protocol also provide training and experience for members of the NIAID infectious diseases and allergy and immunology fellowship training programs as well as to provide a mechanism for the members of the Laboratory of Clinical Infectious Diseases to maintain their clinical skills. It is anticipated that the patients will receive a degree of clinical evaluation, care and monitoring more extensive than that generally available and that specimens collected from them can sometimes be used for laboratory studies related to inflammatory conditions. Also, this protocol may serve as a start point to studies of syndromes or diseases not being addressed by specific protocols, and therefore, can be used to evaluate family members of patients with inflammatory conditions when appropriate in order to try to understand further the disease before embarking in a specific protocol.