9.2 AEs, SAEs and SUSARs 9.2.1 Adverse events (AEs) See also section 8.7. Serious adverse events caused by a missed appendicitis will be reported immediately when they occur. If a missed appendicitis leads to a prolongation of hospitalization of less than 10 days the investigators will consider this as an adverse event and take no further action unless this exceeds 2% after inclusion of every quartile of patients.