Actually, is approved for the treatment of chronic myelogenous leukemia 7 and progressed malignant gastrointestinal stromal tumors; since altered PDGF signaling play an important role in the skin and pulmonary fibrosis, Imatinib can have therapeutic potential in the treatment of disorders accompanied by overexpression of this growth factor. Since fibrotic complication are disfiguring and responsible for great suffering and mortality, we expect that this drug can confer substantial benefit in patient with scleroderma.