Then a comparative analysis will compare the proportions of main variables between the different treatment groups (peripheral, placenta, and cord blood parasitaemia, LBW, prevalence of resistant strains, mutations profiles, clinical and parasitological responses) using the chi-square test. The means (birthweight, haemoglobin concentrations, and number of clinical attacks) will be compared between groups by t-test and one way analysis of variance. Stratified or multivariate analysis tests will be used when necessary.