Epidemiologic studies in adults have found that associated with the development of coronary artery disease are a number of risk factors including age, sex, hypercholesterolemia, hypertension, cigarette smoking, diabetes, a family history of coronary artery disease, obesity, lack of physical activity, and perhaps coronary prone behavior. Of the modifiable factors, hypercholesterolemia, hypertension, and cigarette smoking have the greatest predictive value.