Then Dubois & al compared the effect of an inhibitor of platelet activation, Clopidogrel, and an inhibitor of the activation of the coagulant cascade, low molecular weight heparin (LMWH) on tumor growth and thrombosis associated with cancer. Concentrations of drugs used were calculated to induce a 50% reduction of thrombus formation following a laser-induced injury in healthy mice. A diminution of kinetics of tumor growth was observed in mice treated by the 2 drugs in comparison with non-treated mice. Twenty days following injection of cancer cells, the volume of the tumor was reduced by 85% and 87% when LMHW or Clopidogrel were used, respectively. However, kinetics of tumor growth and volumes of tumors 20 days post-injection were similar in mice treated by Clopidogrel in presence or absence of pathological TF expressed by cancer cells.