In the industrialized and developing countries, the main cause of blindness is the diabetic retinopathy (9). Followed close in the United States and Europe by Age related Macular Degeneration (10). The most frequent cause of loss of vision in diabetic retinopathy is macular edema (7). Its incidence is between 13.9 to 25.4% (15). It is characterized by the accumulation of intraretinal liquid at level of the outer plexiform and internal nuclear layers, with the subsequent thickening of the macula (13,15). The diabetic macular Edema is associated to high levels of VEGF in the vitreous (7,8,9). At the moment, the gold standard in the treatment of the proliferative retinopathy is the laser photocoagulation(9). The photocoagulation of the macular area for the treatment of diffuse or focal edema, produces a 50% decrease risk of severe visual loss. Nevertheless the long-term prognosis continues being poor (15).