Study design and participants This was a randomized controlled clinical trial of 48 weeks on subjects with T2DM between July 2011 and October 2012. Two hundred and four diabetic subjects aged 28-65 years were included in the study. Subjects had A1C >8.0% and had indication for starting insulin. They were randomly allocated to two groups using a simple randomization method. Any current and prior medications were acceptable for inclusion of participant except any type of insulin being evaluated. Demographic and anthropometric variables were recorded. Hypoglycemia events and laboratory data including FPG, HbA1c and lipid profiles were measured every three months. In addition, quality of life was assessed with self-administered standard EQ-5D questionnaire (Brooks, Rabin et al. 2003).