The intended use of these samples is to enable future research into the diagnostics, prognostics and biologic understanding of depression. The samples will be primarily used by investigators affiliated with UT Southwestern, but will also be released to public and private collaborators in a HIPAA compliant fashion (i.e., de-identified). Development of cell lines and DNA libraries may occur with these samples. Samples may be used by investigators not affiliated with UT Southwestern if they are collaborating with a UTSW investigator. Also, samples may be used by colleagues at other institutions who are conducting their own IRB -approved research. Furthermore, de-identified samples can be provided to collaborators in industry if appropriate technology transfer agreements are in place. Samples sent to investigators or private entities outside of UT Southwestern will have a charge associated with them based on sample cost and projected use of the samples. Any specimen or data can be released to collaborators (outlined above) as long as it is released in a HIPAA compliant fashion (i.e., de-identified).