Sickle cell disease (SCD) disease is inherited as an autosomal recessive trait that results in several interactive processes: polymerization of hemoglobin S (HbS), hemolysis, nitric oxide depletion, and vaso-occlusion.[3] The most common manifestations of sickle cell disease are vaso-occlusive pain events, specifically dactylitis which typically occurs as the first clinical manifestation.[4] As patients age, the early onset peripheral pain moves to more central regions resulting in increased severity of vaso-occlusive crises.[4] Pain from the blockage of sickeled cells in vessels causes poor blood flow to a localized area. There are few clinical and laboratory findings to indicate the severity of pain associated with sickle cell crisis,[4] making it difficult for a physician to identify the amount of pain the patient actually experiences. Length of stay in the hospital depends largely on physician discretion and patient report.