POTENTIAL RISKS OF INVESTIGATIONAL INTERVENTIONS AND THEIR PREVENTION. Potential risk: Barotrauma. Preventive measures: This potential risk is equally high during CMV or HFO. We also do not anticipate any notable clinical complications due to the use of high-frequency, high mPaw HFO without cuff leak, as its duration of use will not exceed the protocol-pre-specified time limit of 60 min.