Statistical analysis phase 2 In each group, average physical, biochemical and metabolic variables and area under the curve (AUC) glucose and insulin values at recruitment (baseline) will be compared with follow-up values, with Student's t tests for paired data, or non-parametric tests, if specified. The comparison between the delta of the variables measured at baseline and follow-up for the group treated with LibramedR and the placebo group will be performed with Student's t test with two queues for unpaired data or with non-parametric test, if specified. Hormonal and metabolic parameters change during afterload of glucose in the two groups will be compared with ANOVA for repeated measures.