Based on observations, the investigators hypothesized that inhibition of platelet activation by reducing both thrombosis associated with cancer and tumor growth could constitute an interesting therapy to treated cancer and thrombosis. To test the hypothesis the investigators then developed a syngeneic orthoptic model of pancreatic cancer and could confirm that when mice were treated with Clopidogrel or Aspirin, the growth of the primary tumor was significantly reduced and the development of metastasis was limited (Mege et al.). However the benefit from aspirin was observed in mice only when treated immediately at time of onset of cancer, id est when injection of cancer cells were performed. On the contrary, the effects of clopidogrel were obtained independently of the tumor size, and tumor development or onset and even once cancer was at an advanced stage. Altogether with the action of anti-platelet drugs on thrombosis, these results indicate that Clopidogrel does represent a promising therapeutic drug to limit thrombosis and reduce the development of tumors and metastasis.