In women younger than 40, at least two menopausal FSH levels (≥40 IU/L) will be sufficient for the diagnosis of POF. It is not essential to have amenorrhea for the diagnosis of POF, because spontaneous menstrual cycles can sometimes be seen after the diagnosis as well. Resumption of normal ovarian function, albeit temporary, in patients with normal karyotypes has been documented in 10 to 20% of patient; thus, resumption of fertility is possible .