- This study has two separate consent forms at the NIH: patients at the NIH Clinical Center can opt to donate their samples for ongoing research on assay development and studying pathways. In addition, patients can opt to donate samples to create preclinical models to study tumor biology and genetics, and to develop new therapies for cancer. Patients enrolled onto this protocol in participating sites will be donating specimens (tumor, blood) for the creation of preclinical models to study tumor biology and genetics, and to develop new therapies for cancer.