- Melanoma lesion accessible for tissue biopsy defined as a superficial skin lesion or a deeper soft-tissue lesion felt to be of minimal risk for an image-guided biopsy. This includes superficial hepatic lesions but does not include pulmonary nodules or deep hepatic lesions near critical anatomic structures. Each patient will be individually discussed by a physician panel comprised of the study PI, a study sub-investigator, and an independent interventional radiologist prior to enrollment.