Therapeutic IV administration of 1g paracetamol results in a plasma concentration of ~12 mg/l. To achieve a desired concentration of ~25 mg/l, in the presence of a forearm blood blow of 50 ml/min, the investigators would intend to administer an IA infusion of 1.25 mg/min. To account for the presence of increased forearm blood flow, the investigators propose to administer 4 mg/min IA paracetamol. To achieve a higher local PA concentration of ~200 mg/l, a concentration comparable to potentially hepatotoxic concentrations following PA overdose, the investigators propose to administer 30 mg/min PA.