Subjects assigned to the “no coronary MSCT angiography” arm will follow up with their referring physician for further evaluation. Additional selection of testing, consultation, and choice of therapy is at the discretion of the referring physician. Coronary CT angiography will not be available to this group of subjects. Otherwise, the protocol will not predetermine the clinical diagnostic or treatment course for the subject. This approach will simulate the previous standard of care for the evaluation of possible angina (prior to the availability of coronary CT angiography in clinical practice). By excluding the option of coronary CT angiography in this group, any possible incremental value of the test can more accurately be assessed.