Docetaxel plus cisplatin is one of options of front line treatment. TAX326- a phase III trial studied docetaxel + cisplatin or carboplatin vs vinorelbine/cisplatin (VC) as first-line therapy for advanced non-small cell lung cancer (NSCLC). The schedule of chemotherapy was 75 mg/m² of docetaxel followed by 75 mg/m² of cisplatin repeated every 3 weeks and Vinorelbine 25 mg/m2 IV day 1, 8, 15, 22 and Cisplatin 100 mg/m2 IV day 1 every 4 weeks. The overall response rate were 32% (docetaxel+cisplatin) and 25%(VC). Docetaxel plus cisplatin showed survival benefit compared to VC (1-year survival rate: 46% v.s. 41%).