Therefore, we are to determine the impacts of CYP 3A5 genetic polymorphisms on tacrolimus trough blood concentration during the first post-operative week and acute rejection rate at 3-month post-transplantation comparing between CYP3A5 expressers (CYP3A5*1 homozygotes or heterozygotes) and CYP3A5 non-expressers (CYP3A5*3 homozygotes).