Daptomycin (Cubicin¨, Novartis Pharma AG, Basel Switzerland) is a cyclic lipopeptide antimicrobial agent active against most Gram-positive bacteria including strains that are resistant to methicillin, vancomycin or linezolid. It binds to the membrane of Gram-positive bacteria and causes rapid depolarization of membrane potential leading to bacterial cell death. Thereby, daptomycin exerts a bactericidal, but non-bacteriolytic effect and does not cause release of subcapsular bacterial components.