Four clinical studies of single-agent weekly docetaxel in patients with NSCLC have been reported. As second-line therapy for NSCLC, weekly docetaxel has been studied by 3 groups (Baylor-Charles 2000; Serke M et al 2001; Garcia-Lopez JL et al 2000 ), and Hainsworth JD and his colleagues studied weekly docetaxel as first-line treatment of NSCLC (Hainsworth JD et al 2000).