In the initial development of docetaxel and paclitaxel, these drugs routinely were administered once every 3 weeks. However, weekly administration of both these agents appears to offer several advantages in terms of toxicity. Both agents can be administered weekly with markedly decreased myelosuppression, while maintaining the same or increased dose intensity( Fennelly D et al 1997; Seidman AD et al 1998; Hainsworth JD et al 1998).