All participants will be queried at each visit regarding the occurrence of adverse events (AE) or serious adverse events (SAE). All unexpected AE and all SAEs will be reviewed by the Site Principal Investigator and reported to the local IRB and reported to Dr. Glenn Graham who will then report to the VA Research & Development Committee and the University of New Mexico Health Science Center Human Research Review Committee. (See Appendix I for AE and SAE definitions). Study sites will be in regular contact with study participants whether or not they receive weekly therapy.