-DOCK8 deficiency patients with 9/10 matched related or 9/10 matched unrelated donors will receive a pre-transplant conditioning regimen consisting of cyclophosphamide 14.5 mg/kg on days -6 and -5, fludarabine 30 mg/m2/day on days -6, -5, -4, -3 and -2, busulfan 3.2 mg/kg IV once daily for three days on-4, -3 and -2, and 200 cGy TBI on day -1. The busulfan dosing will be adjusted based upon a test dose of busulfan given prior to the start of the conditioning regimen. Donor hematopoietic stem cells will be infused on day 0. Post-transplant immunosuppression for graft-versus-host-disease (GVHD) prophylaxis for recipients of 9/10 matched related or unrelated donors will consist of cyclophosphamide 50 mg/kg IV once daily for two days on day s +3 and +4, along with mycophenolate mofetil from day +5 to day +35 and tacrolimus from day +5 to day 180. If there is no evidence of graft-versus-host disease, tacrolimus will be stopped at approximately day+180.