In 1998, the renewal has three specific aims. The first aim was to identify genetic influences on the risk factors that characterize ther metabolic insulin resistance syndrome (including fasting insulin, proinsulin, C-peptide and glucose; body weight and waist circumference; lipoproteins; blood pressure; fibrinogen; factor VII and plasminogen activator inhibitor. Statistical genetic analysis approaches used in the first aim included univariate complex segregation analysis, factor analysis, and quantitative multivariate genetic analysis. The second specific aim was to test for genetic linkage between specific candidate genes involved in lipid metabolism, carbohydrate metabolism, blood pressure, obesity, and hemostasis with genetically influenced risk factors of the metabolic syndrome in Japanese-Americans. The third specific aim was, when the DNA repository had been completed (750 samples by the end of year four), to apply to the NHLBI Mammalian Genotyping Service to perform a whole genome screen to identify new genes involved in susceptibility to the metabolic syndrome.