- Diagnosis of MS based on combined MRI and clinical criteria (Polman et al., 2005) OR presentation with a clinically isolated syndrome consistent with MS and at least two abnormalities on MRI consistent with MS OR diagnosis of another neurological disease of the CNS (see Section 6.1.2) OR patients with other diseases who are receiving identical DMTs as the MS cohort OR patients who acquire an MS-like disease while receiving immunomodulatory agents for a different indication.