This trial is a multi-center, parallel design comparing open label BoNT-A paired with rehabilitation therapy (OT) versus BoNT-A alone in patients diagnosed with post-stroke focal upper limb spasticity. Cohort 1 will receive BoNT-A plus rehabilitation therapy for the duration of the study (for up to 2 injections of BoNT-A) while Cohort 2 will receive BoNT-A alone. The injection protocol will closely follow the design of the Allergan 191622-056 study with the inclusion of rehabilitation therapy intervention. Those randomized to BoNT-A alone will not be able to start any new therapy or exercise therapy while in the study. Two types of patients will be recruited for the study, those naïve to BoNT-A and those who have received BoNT-A for treatment of their spasticity. Given that BoNT-A has temporary effects, the second group of patients is not expected to react differently that patients naïve to the intervention. The sites will contact patients previously enrolled in the 191622-008, 025 and 056 protocols to determine if they are eligible for involvement in the BoNT-A / rehabilitation study. In addition, the sites will recruit from the local community patients who have and have not received BoNT-A treatment for their spasticity by placing a notice in the stroke club newsletters, contacting local physician and rehabilitation offices, and posting fliers in area hospitals. Patients will be screened for eligibility during an interview with a study team member. Eligible patients will complete the informed consent process, sign a consent form, HIPPA. A blinded study physician will perform a physical examination and focal exam of the affected limb obtaining Modified Ashworth Scale scores for the elbow, wrist, finger, and thumb. Following the baseline visit, appointments will be scheduled for the next visit (Study Visit 1 {Week 0}, injection of BoNT-A. Prior to injection,, patients will be evaluated by a Therapist, blinded to treatment who will do the Functional Independence Measure (FIM) and the Fugl-Meyer Assessment of Sensorimotor Recovery after Stroke (Upper Extremity subsection). Participants will receive IM injections of BoNT-A between 200 and 400 Units with the total dose not to exceed 6 U / kg. The primary targets for BoNT-A injection are the wrist and finger flexor muscles (flexor carpi radialis, flexor carpi ulnaris, flexor digitorum profundus, flexor digitorum superficialis). Additional target muscles include biceps, brachioradialis, brachialis, pronator quadratus, pronator teres, flexor pollicis brevis / opponens, adductor pollicis, flexor pollicis longus, and lumbricales / interossei. The goal of the injections is to reduce spasticity causing such events as flexed elbow, pronated forearm, flexed wrist, thumb in palm, clenched fist, and hand deformity. It is not necessary to administer the same dose or inject the same muscles at each injection visit. The treatment should be guided by the spasticity measured and the clinical judgment of the Investigator. All injections will be performed with the assistance of EMG guidance for muscle localization. Randomization to either BoNT-A + rehab or BoNT-A alone will occur after the first injection. Randomization schedule will be determined by sequential lettered sealed envelopes sent to each site, generated by the independent analyst.