Clinic examinations were completed in June 1999. The cohort will continue to be followed with bi-annual phone calls to assess study endpoints, including: myocardial infarction (MI), stroke, congestive heart failure, peripheral claudication, angina, TIA and death. CHS investigators will also continue analyses of previously collected serum and DNA samples; analyses of recently collected cross-sectional data and analyses of longitudinal data. Close-out of reading centers is underway, but the reading center principal investigators will continue their study involvement, primarily through continued data analyses and publication of study results.