In order to support and improve the efficiency of clinical research in oncology, the University of Pavia and the IRCCS Fondazione Salvatore Maugeri of Pavia developed and implemented a novel ICT platform, called Onco-i2b2, grounded on the i2b2 software and installed in the IRCCS Fondazione S. Maugeri, Pavia. Onco-i2b2 is able to integrate data from different sources inside the i2b2 data warehouse through the implementation of a complex IT architecture, which includes development of new i2b2-cells for data analysis.