The systemic or invasive fungal infection must be present at baseline and documented within four weeks preceding study entry as follows: (1) positive histopathology with evidence of tissue invasion by fungal elements, or (2) positive serology where diagnostic (CSF cryptococcal antigen; serum or CSF Coccidioides antibody; serum, CSF or urine Histoplasma antigen), or (3) positive mycologic culture from a normally sterile site, taken during the current episode of infection.