Recurrent infections following the 7 day regimen will receive artesunate 4 mg/kg/day for 7 days. Recurrences following the MAS3 regimen will receive artesunate 6 mg/kg/day for 7 days Children aged over 8 years will receive doxycycline 200mg day in addition, and those between 6 and 8 will receive clindamycin 10mg/kg bid Patients with recrudescences will be restudied as above provided they agree.