1. Population Subjects will be selected according these inclusion criteria: aged above 35 years, history of type 2 diabetes and mild hypertension (blood pressure < 160 X 100 mmHg) no longer than 15 years, body mass index < 35 Kg/m2, and glycated hemoglobin (HbA1c) between 7,0 e 10,5%. Exclusion criteria are: smoking within the last six months, pregnancy or breastfeeding; creatinine clearance < 45 ml/min/m2 (MDRD); use of NPH (neutral protamine Hagedorn) or/and regular insulin, pioglitazone, GLP-1 receptor agonist, DPP-4 inhibitor or acarbose; a serum alanine aminotransferase or aspartate aminotransferase level of more than 3 times the upper limit of the normal range; subjects with ischemic heart disease, cerebrovascular disease, other atherosclerotic disease, cancer, or heart failure in functional classes II, III and IV; stress test with typical chest pain or with ST segment depression ≥ 1 mm, with horizontal or descendent and duration of 0.08 seconds after the J point; use of 3 or more anti hypertensive drugs, which characterizes a resistance hypertension; intolerance to metformin, and inability to give informed consent.