You will be taken off the study if you do not have a partial or complete response following 3 cycles of bortezomib/rituximab and 2 cycles of modified R-Hyper-CVAD. You will be taken off the study if the disease gets worse after all planned therapy that the study doctor feels requires repetition. You will be taken off the study if intolerable side effects occur. You will be taken off the study if treatment with bortezomib is delayed for more than 2 weeks. You will be taken off the study if you develop certain other illnesses, or if there are certain changes in your health that the study doctor decides may make further treatment with the study drugs to be unacceptable.