Schiller JH et al. conducted a randomized study to determine whether any of three chemotherapy regimens was superior to cisplatin and paclitaxel in patients with advanced non-small-cell lung cancer (Schiller JH et al. 2000). Patients with advanced non-small-cell lung cancer were randomly assigned to a reference regimen of cisplatin and paclitaxel or to one of three experimental regimens: cisplatin and gemcitabine, cisplatin and docetaxel, or carboplatin and paclitaxel. However, none of four chemotherapy regimens offered a significant advantage over the others in the treatment of advanced non-small-cell lung cancer. GC provided longer time to progression than other three regimens.