The study was renewed in 1996 through August, 2001. A 3.25 year followup examination (FU1) of a cohort of 2,296 Mexican men and women, ages 35-64 years at baseline, was completed. The cohort was re-examined at 3.25-year intervals (6.5 years (FU2) and 9.75 years (FU3) after baseline). The investigators tested the hypothesis that different risk factors would prevail in the early (more than 3.25 years prior to conversion to diabetes) than in the late (3.25 years or less prior to conversion) prediabetic period. They hypothesized that in the early prediabetic period risk factors associated with the Insulin Resistance Syndrome would predominate, i.e., high "specific" insulin concentration (measured by a specific immunoassay), hypertriglyceridemia, low HDL-cholesterol, and hypertension, whereas in the late prediabetic period factors associated with insulin secretory failure, i.e., increased proinsulin and low "specific" insulin, would predominate.