Dose: The recent study of Shifren et al [2000] used continuous transdermal patch and reached blood levels of 3.0nmoles/L (5x baseline) in post-menopausal women, with no side effects over 12 weeks. Goldstat et al [2003] looked at transdermal gel 10mg, which is applied daily but washes off as the day wears on, for 12 weeks with no side effects in pre-menopausal women. They reached blood levels of 2.6nmoles/L (2.5x baseline). Tuiten et al [2000] used sublingual one time dose of 0.5mg, reaching a peak blood level of 25nmoles/L (10x baseline) at 10 minutes which returned to baseline within 90 minutes. We propose to minimize side effects and maximize benefit by single application use of 50mg testosterone in transdermal gel to be used only up to twice a week. Blood levels from this dose from Wang et al [2000] should be about 20nmoles/L. Since patients are instructed to shower after intercourse, these blood levels should exist for only 4-8 hours twice a week. Based on Tuiten et al [2000] a short pulse of testosterone up to these levels is necessary to achieve psychophysiological effects, and thus we request permission to use a dose of 50mg Androgel which would be too high if used daily chronically in women.