METHODS: Fifteen HIV-infected subjects already being treated with IDV/RTV containing ARV therapy (800/100 mg bid) will be recruited from the Grady Infectious Disease Clinic (IDP). Initially, blood samples will be collected at time 0, 1, 2, 3, 4, 6, 8, 10, and 12 hours for a baseline 12-hour pharmacokinetics study of RTV and IDV. Fos-APV 700 mg bid will be added to this regimen for 5 days. At the end of which blood samples will be collected at time 0, 1, 2, 3, 4, 6, 8, 10, and 12 hours for IDV, RTV and APV pharmacokinetic parameters.