Patients must have the following clinical laboratory values: (a) Granulocyte count of greater than or equal to 2,000/mm(3); (b) Platelets greater than or equal to 100,000/mm(3); (c) Serum creatinine less than or equal to 1.5 mg/dl; (d) Bilirubin less than or equal to 1.6 mg/dl, ALT, AST less than or equal to 1.5 times the upper limit of normal, alkaline phosphatase less than or equal to 1.5 times the upper limit of normal, (ALT, AST, alkaline phosphatase less than or equal to 3 times the upper limit in presence of liver metastases); (e) Prothrombin Time (PT) and activated partial thromboplastin time (aPTT) less than or equal to 1.5 times the upper limit of normal; (f) Hematocrit greater than or equal to 30% (may be corrected by transfusion); (g) Patients should have daily T max less than or equal to 38.0 degrees C.