- To assess the relationships, in the study group as a whole and within each treatment group, between renal outcome variables (ESRD, doubling serum creatinine, GFR decline, proteinuria) and fatal and non-fatal cardiovascular events, between achieved blood pressure or metabolic control and renal and/or cardiovascular outcome variables and between achieved proteinuria reduction or residual follow-up proteinuria and renal and/or cardiovascular outcome variables.