Artesunate should produce parasite reduction ratios of approximately 10,000/cycle, which result in parasite clearance times which are usually less than 48 hours. If six patients in either treatment group have PCTs >96 hours then the dosage of artesunate in that treatment arm will be increased AS7 2mg/kg/day increases to AS7 4mg/kg/day MAS3 4mg/kg/day increases to MAS3 6mg/kg/day The sample size will be reviewed at this time.