- Patients enrolled on the dose escalation for intermittent ABT-888 portion of the study must histologically or cytologically confirmed diagnosis of malignancy that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective or for whom CPT-11 treatment would be a viable therapy regimen; patients with solid hematologic malignancies (Hodgkin's and non-Hodgkin's lymphomas) may be included as long as a bone marrow has been performed within 6 weeks of treatment; once the recommended phase 2 dose is determined, additional patients will be enrolled who MUST have a deleterious mutation in BRCA and have human epidermal growth factor receptor 2 (Her-2) negative, estrogen receptor (ER) negative (defined as less than 1% ER by immunohistochemistry [IHC]) and progesterone receptor (PR) negative breast cancer (defined as less than 1% PR staining by IHC)