All patients will undergo thorough surgical resection of the primary lung tumor, and evidence of promoter hypermethylation of gene(s) must be present in the tumor specimen and/or blood sample (plasma or WBC). The collection of tumor specimen will be considered a priority to correlate the tumor "methylation pattern/profile" with the serum "methylation pattern/profile". If tumor specimen is not available for any reason, but the patient has at least one of the 9 targeted genes hypermethylated in the serum, the patient is eligible to be enrolled into the trial.