PCT-day-to-day change analysis Standard empiric antimicrobial treatment of sepsis in this ICU includes: Meropenem and Ciprofloxacin, when relevant supplemented with: Metronidazole, Vancomycin, Linezolid and occasionally other antibiotics according to clinical findings, patient tolerance, suspected site of infection and bacterial cultures from foci and from surveillance cultures combined with susceptibility patterns. Treatment of invasive fungal infection included Caspofungin, Liposomal Amphotericin B or Voriconazole, or combination therapy with these according to Candida species identification and susceptibility pattern from Minimal Inhibitory Concentration (MIC) in surveillance cultures.