In another experiment, the Wistar-Furth rat, an inbred strain resistant to actions of mineralocorticoids, was used to study the concept that mineralocorticoids contribute to progressive renal injury. Renal damage, as evidenced by albuminuria and glomerulosclerosis, in response to 5/6 nephrectomy was markedly less in Wistar-Furth rats compared to Wistar rats. Treatment of hypertension seen in the nephrectomized Wistar rats did not protect them from renal injury suggesting again that mineralocorticoid mediated deleterious effect was independent of the blood pressure effect.