PROCEDURES Subjects will be screened by the clinicians in outpatient units in Hong Kong. They will be asked to sign the consent form when they agree to attend the study. Afterwards, they will be randomly divided into their respective intervention group. Each subject will be given a subject number, which will correspond to the group assignment. There will be two sessions of assessments. In the first session, all 120 subjects will be assessed by an investigator for their cognitive function, severity of symptoms, physical fitness, body-perception, drug adherence, quality of life, and medication side-effects. In the second session, the first 20 subjects recruited into each group will undergo a structural MRI and functional MRI (resting) scan at baseline.