- Need for supportive care treatment(s) interfering with study treatment. E7. Treatment with any of the following anti-cancer therapies prior to the first dose of study treatment: radiation therapy, surgery or tumor embolization within 14 days prior to the first dose of study treatment OR immunotherapy within 28 days OR chemotherapy, biologic therapy, investigational therapy or hormonal therapy within 14 days or 5 half-lives of a drug (whichever is longer). Palliative radiotherapy is authorized only if the irradiated field does not include target lesions.