Optional biopsies will be performed in adult patients only at baseline and after 3-5 days of treatment (D3-D5) to evaluate early drug effect. A third optional biopsy after completion of 4 weeks of therapy (between C1D28 and C2D7) may be collected with the intention of providing further information about disease response to treatment. Depending on results of initial gene expression profiles, the timing of the biopsies may be adjusted, but without change in total number of biopsies per patient.