It had been reported that AML patients achieved lower MRD level had an extremely lower relapse rate. It had also been reported that patients treated with IA regimen had a significant higher long-term survival than those with DA regimen .22-24 Therefore, we speculated that the more favorable outcome in IA group may be associated with a lower MRD level and higher remission quality. This study is also to conduct a prospective analysis on the alteration of WT1 and MDR1 gene expression level after induction therapy with IA or DA separately to identify whether induction therapy with IA regimen has a lower MRD level and a higher remission quality than that of DA regimen.