GLUCOSE METABOLISM AND MIGRAINE The relationship between migraine headaches and hunger is an accepted and well documented phenomenon. Missing meals can precipitate or trigger a migraine in susceptible individuals. Shaw et al., 1977 showed that migraine patients had impaired tolerance to glucose during migraine attacks compared with control studies. There was an elevation of plasma free fatty acid (FFA) levels during the migraine attacks. Growth hormone and cortisol were elevated and insulin was depressed during attacks. Patients with migraine have impaired insulin sensitivity (Rainero, et al., 2005). During the oral glucose tolerance test (OGTT), glucose plasma concentrations were significantly higher in migraineurs than in controls. Insulin sensitivity (measured by ISI-stumvoll and OGIS-180 indexes) was significantly altered in migraine. Cavestro et al. (2007) reported that headache patients had elevated blood glucose levels when compared to controls. They also documented that insulin levels were elevated in migraineurs when compared to control patients and other headache patients. Additional studies are needed to explore the role of impaired glucose metabolism in migraine including the role that glucose metabolism may play in the development of new therapies for migraine.