After anesthesia induction, a left sided double-lumen endotracheal tube will be inserted and pressure support ventilation will be adjusted to optimize gas exchanges and minimize lung hyperinflation with low tidal volume (5-6 ml/kg), high inspiratory oxygen fraction (50-80%) and positive end expiratory pressure levels (PEEP, 4-12 cm H2O). Periodically, lung recruitment maneuvers will also be performed to re-open alveolar collapsed areas. Anesthesia will be maintained by infusing propofol targeted to achieve bispectral electroencephalographic values between 40 and 60. Lung resection with systematic lymph node dissection will be performed through an anterolateral muscle-sparing thoracotomy.