This is a longitudinal observational study designed to utilize health IT advances to collect information from patients undergoing routine care. This information will be collected as part of routine care and stored in a database for research purposes. Patients undergoing routine care from their providers will be invited to participate in the UTSW Depression Cohort. After obtaining informed consent, the CDRCC team will collect information from sources outlined in background section of protocol and store it in a secure UT Southwestern network database protected by a security firewall. A schematic representation of this information processing is shown on page 7 of the protocol. The CDRCC team will also collect specimens which are obtained as part of standard of care and are beyond the amount needed for routine clinical care. For research-only purposes, CDRCC team will also collect blood, saliva, stool and urine specimens at regular intervals described in subsequent section with the consent of study participant.