Study Design Summary 24-month randomized controlled parallel-group study (IRMCI Study) of overweight-or-obese pre-diabetes older patients (IRMCI-1) or untreated type 2 diabetes (IRMCI-2) older patients, all with amnestic MCI or non-amnestic multi-domain MCI, will be randomly assigned within Apolipoprotein E4 (ApoE4) positive and ApoE4 negative strata to: