A range of alternative analgesic techniques can be used for major liver or pancreatic resections. A single dose of intrathecal morphine (ITM), administered immediately before surgery, followed by postoperative patient-controlled morphine analgesia (IV PCA), has been demonstrated to provide satisfactory postoperative pain relief which was not inferior to continuous epidural analgesia up to 48 hours after hepatic surgery [8, 9]. Another study in patients undergoing hepato-pancreato-biliary surgery has shown that ITM, compared with thoracic epidural analgesia, is associated with a reduced incidence of postoperative hypotension, intravenous fluid requirements, hospitalization, and incidence of respiratory complications [10]. Alternatively, few reports have demonstrated the advantage of using continuous administration of intravenous (IV) short-acting opioids, such as remifentanil. This regime has been shown to facilitate earlier extubation, to provide excellent intraoperative hemodynamic stability and rapid recovery [11]. Nevertheless, as remifentanil is rapidly metabolized, there is a need at the end of surgery to initiate another post-operative pain strategy to prevent unacceptable pain in the post-operative period. This has been accomplished by the administration of morphine which has been shown to provide an effective postoperative pain control (a bolus followed by IV PCA).