- Evaluate whether CR reduces the glomerular filtration rate (GFR) in subjects with abdominal obesity and type 2 diabetes, but still no evidence of renal disease [serum creatinine <1.2 mg/dL and albuminuria <20 μg/min (median of the 3 consecutive measurements in overnight urine collections)], and to assess whether CR reduces also kidney perfusion and/or filtration fraction, and whether these hemodynamic changes correlate with a concomitant reduction in urinary albumin excretion rate.