INTRODUCTION More than 30.000 individuals are living with a colorectal cancer (CRC) diagnosis in Denmark today. Due to marked advances in surgical and medical treatment, as well as novel screening programs, this number is expected to increase over the coming years. Numerous studies have shown that physical activity is inversely associated with colorectal cancer risk. A meta-analysis of 52 studies found that regular participation in physical activity reduced disease risk by 24% (HR: 0.76 , 95%Confidence Interval [95%CI]: 0.72 - 0.81). Recent evidence furthermore shows that physical activity after a CRC diagnosis is a strong independent predictor for overall survival, CRC-specific survival, and survival after disease relapse. CRC patients who adhere to the current recommendation of at least 150 min moderate intensity physical activity per week have an estimated 10-40% lower CRC-specific and 20-50% lower overall mortality risk in comparison to sedentary counterparts. The causative mechanisms responsible for this protective effect are not fully elucidated, but several studies have shown that metabolic health factors, i.e. overweight/adiposity, systemic levels of glucose, insulin, Insulin-like Growth Factor (IGF)-1, leptin, adiponectin and inflammatory cytokines (TNF-α, CRP) are associated with CRC prognosis. These factors are, under normal circumstances modifiable through physical activity and exercise, which may constitute a plausible mode of action, through which, exercise may reduce risk of disease progression as well as development and/or progression of cardio-metabolic co-morbid disorders.