Drug eluting stents have shown great promise in coronary artery interventions. One of these drugs, sirolimus, that is a natural macrocyclic lactone with potent immunosuppressive and antimitotic action, has been tried also at femoral arteries. Sirolimus-eluting self-expanding nitinol SMART stent was compared in a small (57 patients) randomized, double-blind multi-center study with the bare metal stent (SIROCCO II trial) in treating femoral artery lesions with average length of 8 cm (Duda et al 2005). Exceptionally low angiographically verified binary restenosis rate of 7.7% was registered at the bare metal stent group. Although the restenosis rate was zero and there was less mean late loss in diameter in the drug stent group the difference did not reach statistical difference.