6. CONCOMITANT AND DISALLOWED MEDICATIONS As per standard of care (and irrespective of the research study), in addition to doxycycline, patients will take 400 mcg of misoprostol buccally 3 hours before their procedure. It is also standard of care that patients are able to take either Ibuprofen or Tylenol #3 as needed for pain before their procedure. They will also be permitted to take any other medications that they take on a daily basis. None of these medications are part of the research protocol. They will be instructed not to take any antiemetics. The investigators will record any medications that are used.