Adjuvant treatment already at diagnosis of thyrotoxicosis has been chosen in the aim to prevent clinical ophthalmopathy due to the fact that morphological changes of ophthalmopathy in the orbital room exist in Graves´ thyrotoxicosis in up to 98% of the patients without clinical symptoms. The long period of time for treatment with diclofenac is justified by the knowledge that the majority of patients at risk for developing ophthalmopathy exhibit clinical symptoms within 18 months.