The results of a multicenter study of ibuprofen intervention in patients with sepsis performed at two medical centers between 1985 and 1987 demonstrated the antipyretic effect of ibuprofen with accompanying decrease in heart rate, reduction in peak airway pressure during the time of intervention, and evidence from urine assays of reduced in vivo production of PGI2 and TxA2. Results suggested that PGI2 production correlated inversely with systemic vascular resistance and the TxA2 production correlated directly with pPA and airway resistance. Several parameters indicating beneficial effects tended toward improvement during ibuprofen intervention.