Haemoglobin (Hb) ≥ 9.0 g/dL; Absolute neutrophil count (ANC) ≥ 1.5 x 10^9/L; Platelet count ≥ 100 x 10^9/L; Serum bilirubin ≤ 1.5 x upper limit of normal (ULN); Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 x (ULN) unless raised due to tumour in which case up to 5 x ULN is permissible; Either: Calculated creatinine clearance ≥ 50 mL/min (uncorrected value) Or: Isotope clearance measurement ≥ 50mL/min (corrected); Serum calcium (corrected for albumin levels) ≤ 1.0 x ULN; INR and PTT ≤ 1.5 x ULN