Following surgical resection of NSCLC and test positive for promoter hypermethylation in at least one (1) of the targeted TSGs described, patient will start adjuvant conventional chemotherapy (doublet platinum-based chemotherapy) for stage IB-IIIA NSCLC. In the case a patient with stage IB refuses adjuvant chemotherapy, the patient still can be enrolled into Part B of the study if he/she understands the concept of the trial and sign an informed consent.