- Currently treated with depot medications. Because of the long half-life of depot medications such as paliperidone palmitate (Invega Sustenna), applicants to our program will be excluded if they are currently receiving depot medications monthly. However, applicants may decide to switch from depot to oral medications on their own, in conjunction with their personal physician, before coming to the program. This is not part of research and we do not participate in this decision. A sufficient washout period based on the particular long-acting injectable medication s elimination half-life will be required in order for prospective participants to be eligible. Most such medications require a 6-month washout period, but some with shorter elimination half-lives, such as risperidone powder (Risperdal Consta), only require 3 months. Subjects may complete the last 3 months of washout in the inpatient unit while being evaluated under the standard protocol.