How will investigators assess the potential participant's capacity to consent? Capacity to consent will be assessed by research assistants (RA) who will be extensively trained by the PI and co-investigators using a standardized procedure. Investigators first provide the consent form to the patient and caregiver together and allow them to review it. RAs then describe the key points of the form, pointing to the areas on the form where the information is described in more detail. They then ask a series of yes/no questions to assess understanding of the information in the form. If the participant cannot answer the questions, RAs review the material again and point to the section on the form. Investigators then repeat the questions. If participants are unable to answer all of the questions on their own after review, RAs consider them to lack capacity to consent. RAs then ask them if they would like to participate in the study to obtain their assent. RAs say that they are going to ask the caregiver to sign the form on the participant's behalf to obtain written consent. Most of the team's research assistants have been and are psychology graduate students who are highly sensitive to working with vulnerable patients. Investigators train new research staff by having them role play the consent process until senior personnel determine that they are adequately prepared. They then observe senior personnel performing the consent process on at least one study participant. Subsequently they are observed performing the consent process until senior personnel determine that they are competent. Investigators/RAs also have weekly team meetings to discuss any difficulties that arise during consent or any other study procedure.