Hepatocellular carcinoma based on the diagnostic criteria of European Association for the Study of the Liver (EASL), either confirmed cyto-histologically or confirmed non-invasively (restricted to cirrhotic patients) by radiological criteria (two coincident imaging techniques and focal lesion >2 cm with arterial hypervascularization) or combined criteria (one imaging technique associated with alpha-fetoprotein (AFP), focal lesion >2 cm with arterial hypervascularization, and AFP levels >400 ng/ml); Hepatitis B virus carrier serologically; Child-Pugh grade A for cirrhosis; The patients should be considered not suitable for surgery, ablation therapy, or trans-arterial chemoembolization judged by the caring physician. In addition, no systemic anti-cancer therapy with high priority is available judged by the caring physician.