Children between the ages of 3 months to 16 years with acute bacterial meningitis will be recruited. After obtaining baseline blood parameters including muscular enzymes, renal function, hepatic function, and blood cultures, a lumbar puncture is performed and standard of care therapy with ceftriaxone 100mg/kg (top dose 4g i.v.) is initiated. 24 hours after hospitalisation a single dose of daptomycin at an age- dependent dosage, is administered i.v. over 15 min. shortly before or after the second dose of ceftriaxone. 4-8 hours after daptomycin administration a second lumbar puncture is performed to obtain a CSF sample for measurement of peak daptomycin levels. Serum concentrations of daptomycin are measured immediately after i.v. administration, at the time of lumbar puncture and 24 hours after daptomycin administration.