A novel formulation of conditioning that could condense the pattern of delivery of physiologically-effective, dose-related stimuli, while simultaneously maintaining the vast proportion of potential gains in performance, would offer advantages to patients and clinicians for logistical versatility with which a package of conditioning might be delivered. This would be especially important within the relatively short period of time between the patients electing for surgery after clinical consultation and a surgical procedure, if pre-habilitation were to be incorporated effectively within care pathways. Recent studies have shown that with careful periodization and micro-cyclical management of the mode of exercise-conditioning, patterning of exercise intensity and work/recovery ratios, and progression of increasing physiological stimuli for adaptation, it is possible to deliver gains in neuromuscular performance within a programme lasting 2-3-weeks, which match 70% of the effects expected during longer programmes (Peer and Gleeson, in press; Peer et al. under review). Additional adaptations to this intervention model would be needed to counteract arthrogenic and autogenic sources of inhibition associated with long-term disease conditions such as OA (Rice et al. 2010), limiting neuromuscular performance and conditioning gains by the intrusion of nociceptive stimuli such as an increase in intra-articular joint pressure (Palmieri-Smith et al. 2007). The cost-neutrality of the embedding pre-habilitative conditioning for improved motor performance might be feasible if a portion of the end-phase rehabilitation following a surgical procedure, which has been shown recently to offer limited gains in performance within the formal care pathway (Bailey et al. 2014), could be sacrificed in favour of an equivalent time- period of conditioning prior to surgery.