7. Abnormal liver function（Note：total bilirubin ＞1.5 times the upper limit of normal，AST or ALT ＞2.5 times the upper limit of normal （Note：5 times the upper limit of normal for patients with liver involvement）），abnormal renal function（Note：serum creatinine ＞1.5 times the upper limit of normal），fluid and electrolyte disorders