5. Adequate hematologic (ANC > 1500/mm^3, platelet count > 100,000/mm^3), renal (serum creatinine < 1.5mg/dL), hepatic [serum bilirubin count < 1.5 x upper limit normal (ULN) and SGOT or SGPT < 2.5 x ULN, for subjects with known liver metastases < 5 x ULN] functions.