- Main outcome measures: high-resolution manometry(HRM) parameters includes maximal pressure, area integral, rise time, duration of the velopharynx and tongue base, maximal pressure of preeupper esophageal sphincter (UES), low pharynx, cricopharyngeus, minimal UES pressure, UES activity time, and nadir UES duration. After apply the SESD, compared the HRM data with the initial data which was obtained before treatment