However, very high 1-year mortality (30-60%) was reported in early allogeneic bone marrow transplant studies, with disease free survival in only 15-30% of patients and no superior survival if compared to ASCT (Bensinger et al., 1996; Bjorkstrand et al., 1996; Barlogie et al., 1995). More recent studies, including allogeneic transplants with nonmyeloablative conditioning regimens, provide more encouraging results (Reynolds et al., 2001; Badros et al., 2002). Recently, a combined treatment with ASCT followed by a non-myeloablative allogeneic stem cell transplant showed very promising outcomes and improved, although still significant toxicity, with CR rates in 55-60% range (Kroger et al., 2002; Maloney et al., 2003). It is too early to determine whether improved responses using this approach will result in an increased survival.