Sample size calculation Despite of the characteristics of this observational study (an international survey) with multiple objectives to evaluate, we decided to include patients according with the calculation of the sample size for the main objective (ICU mortality). In this way, we estimated that 2,600 patients would need to be enrolled for the study to have 90% power to detect a rate of survival to ICU discharge of 23% versus 28% in the previous study, at an overall two-sided alpha level of 0.05, and assuming 20% of missing patients. The secondary ob-jectives will be tested using the same sample size.