We anticipate that majority of newly diagnosed patients will be eligible and will subsequently proceed to autologous stem cell transplant as part of standard therapy of myeloma (NCCN Guidelines 2004) if, as hypothesized, bexxar treatment does have the potential to eliminate clonogenic myeloma stem cells; stem cells collected post-bexxar treatment should be depleted of re-populating myeloma cells. Therefore, this combination of chemotherapy and targeted therapy against clonogenic cells may have a potential of eliminating myeloma clones. Although stem cell collections and autologous stem cell transplants have been used without apparent difficulties in the past in patients treated with anti-CD20 radio-conjugates (Ratanatharatorn et al, 2001; Kaminski et al, 2001; Ansell et al, 2002), we plan to collect backup stem cells prior to treatment with Bexxar, to allow to proceed with the standard stem cell transplant in the unlikely cases of failure of collection of stem cells post-Bexxar. Anti-CD20 radioimmunotherapy was previously used in combination with chemotherapy without additional toxicity (Emmanoulides et al, 2001; Gregory et al, 2001, Press et al, 2003).