Measures Number of seizures Since Lennox-Gastaut Syndrome compose of many seizure types. All seizures were classified according to the International League Against Epilepsy Revised Classification of Seizures [29]. The participants were monitored by video-EEG in order to classify the types and frequencies of seizures, and all of the caregivers were taught how to count and classify seizures on the basis of observations and video recordings. The caregivers were also taught the rules for diary recording prior to the baseline period. All of the caregivers were blinded to both treatment and sham group. In case of the participant who had more than 1 caregiver. The investigator suggested them to refer the daily diary to the person who cared the participant in time.