rifabutin AUC ↓ 0.83 (0.75-0.94) rifabutin Cmin ↓ 0.76 (0.66-0.87) rifabutin Cmax ↓ 0.90 (0.78-1.03) 25-O-desacetyl-rifabutin AUC ↓ 0.83 (0.74-0.92) 25-O-desacetyl-rifabutin Cmin ↓ 0.78 (0.70-0.87) 25-O-desacetyl-rifabutin Cmax ↓ 0.85 (0.72-1.00) etravirine AUC ↓ 0.63 (0.54-0.74) etravirine Cmin ↓ 0.65 (0.56-0.74) etravirine Cmax ↓ 0.63 (0.53-0.74)