Eating disorders: decrease in the amount of food eaten with a consequential dangerous loss in weight. • Skin disorders, burning sensation of the skin, itching, increased perspiration, night sweats. • Musculoskeletal disorders, abnormal increase in tightness of muscle tone, pain, joint pain, muscle pain, back and neck pain. • General disorders, tumour pain, becoming markedly red in the face and other areas of the skin, general discomfort or uneasiness, flu syndrome, fatigue, shaking, multi-organ dysfunction.