sildenafil AUC ↓ 0.43 (0.36-0.51) sildenafil Cmin ND sildenafil Cmax ↓ 0.55 (0.40-0.75) N-desmethyl-sildenafil AUC ↓ 0.59 (0.52-0.68) N-desmethyl-sildenafil Cmin ND N-desmethyl-sildenafil Cmax ↓ 0.75 (0.59-0.96)