The components of the extended controlled release antibiotic formulation are doxycycline hyclate, poly (DL-lactide-co-glycolide) or PLGA, and a lipid matrix comprised of cholesterol, and 2 phosphatidyl-choline phospholipids, specifically dipalmitoylphosphatidylcholine (DPPC) and distearoyl phosphatidylcholine (DSPC).