 Check your syringe contains 1 ml of water for injections.  If you are not sure how to fill your syringe ask your doctor or nurse.  Make sure your syringe does not contain any air bubbles.  With the Enbrel vial upright on a flat surface, such as a table, insert the syringe needle straight down through the centre ring of the grey stopper of the vial (see Diagram 2).