EMSELEX should not be used in people who may be hypersensitive (allergic) to darifenacin or any of the other ingredients, and in patients with: • Urinary retention (difficulty in passing urine) • Gastric retention (when the stomach doesn ’ t empty properly) • Uncontrolled narrow-angle glaucoma (increased eye pressure even with treatment) • Myasthenia gravis (a disease of the nerves causing muscle weakness). • Severe hepatic impairment (severe liver disease). • Severe ulcerative colitis (severe inflammation of the large intestine causing ulceration and bleeding) • Toxic megacolon (a very serious complication of colitis – see above) EMSELEX should not be given to patients at the same time as medicine such cyclosporine (in transplant patients), verapamil (a heart medicine), protease inhibitors (medicines such as ritonavir, used in AIDS patients) or ketoconazole and itraconazole (used to treat fungal infections).