Renal impairment Pharmacokinetic parameters of tenofovir were determined following administration of a single dose of tenofovir disoproxil 245 mg to 40 non-HIV, non-HBV infected patients with varying degrees of renal impairment defined according to baseline creatinine clearance (CrCl) (normal renal function when CrCl > 80 ml/ min; mild with CrCl = 50-79 ml/ min; moderate with CrCl = 30-49 ml/ min and severe with CrCl = 10-29 ml/ min).