Previous studies in animal models have shown that NaP is essential for the production of rhythmic firing to sustained or slowly rising inputs, such as the action potential afterhyperpolarization (AHP) (Kuo et al. 2006; Lee and Heckman 2001). Blocking NaP with riluzole decreases repetitive-firing capabilities (Harvey et al. 2006; Kuo et al. 2006; Kuo et al. 2005; Ptak et al. 2005; Theiss et al. 2007; Urbani and Belluzzi 2000) and reduces gain accompanied by a rightward bias shift in the input-output relation (Kuo et al. 2006; Theiss et al. 2007), which is indicative of an increase in input needed to initiate output. In addition, NaP amplifies and prolongs depolarization responses to brief stimuli (Prescott and De Koninck 2005). CaP, such as the L-type calcium current, are responsible for plateau potentials, which are a sustained depolarization following cessation of current input (Hounsgaard and Kiehn 1989; Morisset and Nagy 1999; Russo and Hounsgaard 1996; Voisin and Nagy 2001). In addition, CaP contributes to prolongation of depolarizing responses to brief stimuli (Prescott and De Koninck 2005).