So far, attempts to discontinue NA therapy before HBsAg seroclearance had yielded variable results. Concerning hepatitis B e antigen (HBeAg)-negative CHB, prior studies found rates of disease relapse to range from 45% to 66% after treatment cessation. A recent multicenter prospective study involving three Hong Kong institutes (including our center) and 184 patients found the 48-week cumulative rate of virologic relapse to be 91.4%. While variations in relapse rates could be explained by the difference in study design and definition of endpoints, an important factor which could play a role is the serum HBsAg level of recruited subjects.