Current evaluation for DKA-related CE necessitates a high index of clinical suspicion and often times such patients receive advanced brain imaging such as computed tomography (CT) scans. While CT scans can identify CE, this imaging modality exposes patients to ionizing radiation, is expensive, and may take considerable time in some instances. Moreover, CE can occur in the absence of acute change on CT and some patients with subclinical CE may go unidentified. Magnetic resonance imaging (MRI) has been used to identify subclinical DKA-related CE, however this is often time-consuming, expensive, requires sedation, or may be unavailable at some centers. Ocular sonography (ultrasound) is an alternative imaging technique that can provide immediate diagnostic capability at the bedside and minimize radiation exposure. This technique has been used to rapidly and accurately detect increased brain swelling through measurement of the optic nerve sheath diameter (ONSD) in a number of clinical situations including pediatric head trauma, hydrocephalus and ventriculoperitoneal shunt malfunctions, and altitude sickness in adults.