Impaired renal function: on the basis of pharmacokinetics, no dosage adjustment is necessary in patients with mild to moderate renal impairment (creatinine clearance of 30-80 ml/ min), while< Nimesulide containing medicinal products > are contraindicated in case of severe renal impairement (creatinine clearance < 30ml/min) (see sections 4.3 and 5.2).