Statistical analysis All data will be statistically analyzed by a statistician blinded to randomization using SPSS 18.0 software. The successive normally distributed variables will be expressed as the mean ± SD. The non-normally distributed variables will be expressed as median and quartile. Classification variables will be expressed as count and percentage. A paired t-test or Wilcoxon Matched-Pairs Signed-Rank Test will be used to compare the continuous variables of the primary and secondary outcome measures at each time point. The chi-square test or Fisher's exact test will be used to compare the classification variables. A P level of <0.05 will be accepted as statistically significant.