CD39 and CD73 was known protein expressed on surface of Th1 and Th17 cell and modulate immune related reaction. Cardiopulmonary bypass (CPB) can induce inflammatory reaction during cardiac surgery, and induce immunosuppression. In recent previous studies, CD39 and CD73 was known to have important role in cancer patients for inducing immunosuppressive reaction and consequently induce cancer cell proliferation. However, the immunosuppressive effect of CD39 and CD73 during CPB time was not evaluated in previous studies.