Treatment description No investigational or commercial agents or therapies other than Sorafenib may be administered with the intent to treat the patient's malignancy. Sorafenib will be given at the dose of 2 tablets of 200mg (400 mg) to be taken twice a day in the morning and in the evening without food (at least 1 hour before or 2 hours after a meal). If a dose reduction is necessary, the Sorafenib dose may be reduced to 200 mg twice a day. If additional dose reduction is required, the dose may be reduced to a single 400 mg dose every other day. Reported adverse events, potential risks, and appropriate dose modifications for are described below. Informed Consent: If a patient is found to meet the eligibility criteria and expresses an interest in participation, Other treatment options will also be discussed with the patient prior to completing informed consent. No study related procedures will be conducted prior to the patient signing the informed consent. The subject will be provided with a copy of the Patient Information Sheet and will be given the opportunity to ask any question or seek clarification.