- Progressive Castration-resistant Prostate Cancer defined as: a rising PSA; or development of new sites of disease in the presence of a suppressed testosterone (<1.5 nmol/l); or if testosterone >1.5 nmol/l, maximum androgen blockade failure (MAB) (MAB = GnRH analogue and peripheral anti-androgen - flutamide 250 mg 3x/day or bicalutamide 50 mg/ day or cyproterone 100mg 3x/day)