Low back pain disability as assessed by Oswestry Low Back Pain Disability questionnaire will be used for the Primary Efficacy Endpoints. Theses Efficacy endpoints will be assessed at Screening, Day 1 (Baseline) and at Week 2, Week 5, Week 10, Week 15, Week 20, Week 30, Week 40, and Week 52(EOS). Lumbar spine joint space, the K-L scoring, degenerative changes, Disc height and lordosis changes, cartilage thickness, in intervertebral kinematics changes, bone marrow lesion volume and size, disc compositional changes, Pain Visual Analog Scale (VAS) Score, mBPI-Severity Score, mBPI Interference Score, will be used for the Secondary Efficacy Endpoints. These Efficacy endpoints will be assessed at Screening and Baseline (Day 1) and at the Week 2, Week 5, Week 10, Week 15, Week 20, Week 30, Week 40, and Week 52(EOS).