These side effects may occur with certain frequencies, which are defined as follows:  very common: affects more than 1 patient in 10  common: affects 1 to 10 patients in 100  uncommon: affects 1 to 10 patients in 1,000  rare: affects 1 to 10 patients in 10,000  very rare: affects less than 1 patient in 10,000  not known: frequency cannot be estimated from the available data.