Other less common adverse events (between 1 and 10 patients out of 100 treated) reported in association with interferon beta include diarrhoea, loss of appetite, vomiting, sleeping difficulty, dizziness, nervousness, itching, rash, nettle-rash, hair loss, dilatation of the blood vessels and palpitation, irregularities and/or changes in menstrual flow and serious reactions of the skin and mucous membranes.