A sub-study will be added that will recruit 60-75 newly diagnosed (within 3 months) patients admitted with acute heart failure. These patients will have serial biomarkers measured within 24 hours of admission, at 3-4 days after admission, at discharge, at 1, 3 and 6 months post discharge from hospital. These serial biomarkers will allow us to assess the effects of heart failure treatment on biomarkers.