Compliance with the weekly CQ chemoprophylaxis will be controlled by giving the women a varying excess of tablets of CQ and placebo to take home and be requested to return the balance at each monthly visit. Health workers will administer the SP (DOT). The first dose of SP will be given at 14 - 24 weeks of gestation and the second dose will be given 28 - 32 weeks of gestation. Health workers will keep records of the gestational age.