National immunization coverage has consistently fallen short of Healthy People 2010 and 2020 goals and has remained relatively stagnant over the past few years for many immunizations. One important group with a high risk of under-immunization are children with chronic medical conditions (CMCs), who are also at increased risk of serious morbidity and even death from vaccine preventable diseases. One of the key interventions to improve immunization coverage in both the general population and children with CMCs is to decrease missed opportunities for immunization. Immunization reminders in the electronic health record (EHR) are a type of clinical decision support (CDS) that can reduce missed opportunities. In a recent project, the investigators successfully employed such reminders to increase influenza immunization.