There are few primary care and multiple sclerosis (MS) clinics that provide full exercise and rehabilitation services for patients with MS, especially in mostly rural, low‐income areas such as Alabama and Mississippi. Telerehabilitation, or the delivery of rehabilitation services over the telephone and/or the Internet, can help fill service gaps for underserved MS patient populations in this region. The proposed study will determine if our evidence‐based rehabilitation and exercise program produces similar health outcomes when delivered in clinic or at home, using pre‐loaded tablets and Interactive Voice Response (IVR) system technology among 820 participants with MS from 30 clinics across Alabama and Mississippi.