- Discuss the plan to transition from the study medication to standard of care treatment per the discretion of heart heart failure provider and the subject. Information will be given to the provider and patient regarding results of the PARADIGM-HF trial and updated ACC/AHA/HFSA heart failure treatment guideline update. The study team will instruct the subject to re-start their standard of care ACE inhibitor at least 36 hours after their last dose of study medication. For example, if the subject takes their last dose of study medication on day 70, the subject will wait one day (day 71) and then re-start their standard of care ACE inhibitor day 72 in the evening.