This is a multi-center trial involving the University of Minnesota, Ohio State University Comprehensive Cancer Center, and Roswell Park Cancer. Cigarette smokers who are eligible will be randomized to Snus, E-cigarette, Nicotine Gum or Lozenge, or Control Group. Participants will enter a 1 week sampling phase. Smokers interested in continuing with the study after the sampling phase will undergo a 2 week baseline assessment phase and will then enter an 8 week intervention. Tobacco use patterns, subjective responses to product, and nicotine and toxicant exposure will be assessed.