Compared with patients with normal renal function, the mean (%CV) tenofovir exposure increased from 2,185 (12%) ng·h/ ml in subjects with CrCl > 80 ml/ min to respectively 3,064 (30%) ng·h/ ml, 6,009 (42%) ng·h/ ml and 15,985 (45%) ng·h/ ml in patients with mild, moderate and severe renal impairment.