- Group C: Cohort C1A: Subjects age ≥ 18 years with relapsed/refractory AML by WHO criteria; Cohort C2: Subjects age ≥ 18 years with relapsed/refractory AML with MLL; Cohort C3: Subjects with previously untreated AML by WHO criteria and who would have met disease eligibility criteria for Group A or B but refuse or are unable to receive chemotherapy and hypomethylating agent as determined by the treating physician