To standardized the protocol the patient's left side is chosen as the test side.The surgical procedure is carried out under local anesthesia containing 2% epinephrine with 1:100,000 epinephrine. The surgical guide is placed on the teeth and is used to mark the position of the implant with round drill till it hits the bone. Mucoperiosteal flaps were raised with mid crestal incision and intrasulcular incision extending to one tooth mesially and another tooth distally. After full thickness flap elevation, the osteotomy sites are prepared using the drilling sequence instructed by the manufacturer. the stem cells are centrifuged in a sterile environment as per the instructions are given by the stem cell bank.(Thawing protocol )Human mesenchymal stem cells (hMSC) are primary cells which can be successfully used for infusion purpose.The following is the recommended protocol for thawing and infusion of these cells:Remove the Cryovial of stem cells from dry ice,defrost the vial containing stem cells by placing in between both the palms with constant, moderate agitation, until ice in the ampule is no longer visible,immediately disinfect the vial with 70% isopropanol.Working under laminar flow hood, open the vial and transfer the contents to a sterile 15ml centrifuge tube and centrifuge at 3500 RPM for 5 minutes. Decant the supernatant and to the pellet add 1 ml of saline.Mix properly and the cells are ready for infusion at the osteotomy site. Remove the contents in a sterile dappen dish and before infusion of stem cells at the osteotomy site the implant is dipped in the solution for 3 minutes so that the stem cells adhere to the titanium implant surface. The same dental surgeon performs all the cases. The dental implants Nobel Biocare Replace select (4.3 *10mm size) 4.3mm diameter and 10mm length is selected and placed in the osteotomy site with IF of 40 Ncm11.Before approximation of the flap, the primary stability of the implant is recorded with the ostell device, which has a transducer attached to the device and a magnetic attachment smart peg is attached to the implant with a plastic peg holder each implant is measured twice from two different angles,around 90 degrees and parallel to the crestal line.The two measurements buccolingually and mesiodistally are recorded and an average of both the values are taken.The measurements values are then transferred into implant stability quotient (ISQ) units, which are given on a scale of 1- 100, with 100 being the highest degree of stability and it works on the principle of resonance frequency analysis (RFA).The smart peg is removed and Healing abutments are placed over the dental implants. The flap is sutured monofilament sutures 4-0.IOPAR are taken with KKD radiograph system, which standardizes the distance between the collimator and the IOPAR.