Saquinavir ↑ Ritonavir ↔ In HIV-infected patients, Invirase or saquinavir soft capsules in combination with ritonavir at doses of 1000/ 100 mg twice daily provide a systemic exposure of saquinavir over a 24 hour period similar to or greater than that achieved with saquinavir soft capsules 1200 mg three times daily (see section 5.2).