Objective/Hypothesis: The objective of this proposal is to test these two advanced MRI methods, DTI and resting-state fMRI, in active-duty military blast-related TBI patients acutely after injury and correlate findings with TBI-related clinical outcomes 6-12 months later. These methods may add clinically useful predictive information following traumatic brain injury that could be of assistance in standardizing diagnostic criteria for TBI, making return-to-duty triage decisions, guiding post-injury rehabilitation, and developing novel therapeutics. The overarching hypothesis guiding this project is that traumatic axonal injury is a principal cause of impaired brain function following blast-related TBI. Specific hypotheses to be tested are: