Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of non-Hodgkin's lymphoma (NHL), comprising approximately 30% of new cases. Treatment results of DLBCL have significantly improved after the introduction of rituximab (R) into CHOP-like, anthracycline-based, treatment schedules, and it is now the standard of care. Nevertheless, even with current R-CHOP-like treatment, approximately 30-40% of patients will ultimately relapse or progress.