At screening a CT or MRI of the chest and abdomen/pelvis will be performed to assess baseline tumour status. In patients with suspected brain metastasis at Screening or if clinically indicated a CT or MRI of the brain will be performed. In patients with known bone metastases of the extremities or in case of suspected bone metastases of the extremities at Screening correlative imaging (X-ray, CT or MRI) has to be performed of the respective area(s). At Visits 8, 11, 14, and 17 (EOS) a CT or MRI of the chest, abdomen and pelvis will be performed. In patients with bone metastases of the extremities detected at baseline or during the study, repeat assessments of the sites of bone metastases (X-ray, CT or MRI) will be performed at Visits 14 and 17 (EOS). An assessment of brain metastasis will be performed only if clinically indicated during the course of the study.