8)Dissemination of project results: We will publish our results in high impact international medical journals to disseminate the results to colleagues around the world. Lectures and presentations in national and international congresses is a natural way to publish the results. An investigator education programme, PhD, is incorporated in the project, which includes presentations and posters in national and international congresses. The project will be registered in an international trial register, according to demands by many journals before publishing.