Interestingly, with the exception of investigations by Theiss (project co-investigator) and colleagues on the effects of riluzole and isradipine on flexion-withdrawal response and changes in volitional strength (Theiss et al. 2008, Theiss et al, 2011), the effects of either agent on motor function, spasms, spasticity and motor unit firing behaviors in chronic SCI have not been systematically studied. As studies by Theiss et al. (2008, 2011) have shown, they provide a safe mechanism to examine contributions of intrinsic neuronal currents to motor impairments.