Patients were randomised to platinum-based chemotherapy, cisplatin 80 mg/ m2 i. v. infusion on day 1 and gemcitabine 1250 mg/ m2 i. v. infusion on days 1 and 8 of every 3-week cycle for up to 6 cycles (CG) with placebo or CG with Avastin at a dose of 7.5 or 15 mg/ kg IV infusion day 1 of every 3-week cycle.