The metabolic effects of new HCV therapies are unknown in HCV-Infection Three HCV protease inhibitors (simeprevir, telaprevir, boceprevir) have been approved for the treatment of genotype 1 infection in combination with interferon and ribavirin. Telaprevir and simeprevir are dosed in combination with PEG-IFN and ribavirin for the initial 12 weeks of treatment. Interferon and ribavirin are dosed for 12 to 36 additional weeks based on early virological response and patient characteristics including liver fibrosis stage. Sofosbuvir is a nucleotide dosed in combination with pegylated interferon and ribavirin for 12 weeks in genotype 1 infected individuals. It can also be used in combination with simeprevir +/- ribavirin for 12 weeks without interferon. Sofosbuvir and ribavirin for 24 weeks is a third viable option of sofosbuvir-containing therapy in genotype 1 infection. Other orally administered HCV antivirals (protease inhibitors, nucleosides, non-nucleosides, assembly inhibitors) in development are effective against genotype 1 and other genotypes as well. Abbvie has developed a 12-week combination DAA regimen consisting of a HCV protease inhibitor (ABT-450 based with ritonavir), a NS5a inhibitor (ABT-267; Ombitasvir), a polymerase inhibitor (ABT-333; Dasabuvir) with or without ribavirin. This regimen was licensed in Canada in December 2014.