Previous treatment failure patients Retreatment of prior treatment failures (relapse and nonresponder patients) with peginterferon alfa-2b in combination with Ribavirin In a non-comparative trial, 2,293 patients with moderate to severe fibrosis who failed previous treatment with combination alpha interferon/ ribavirin were retreated with peginterferon alfa 2b, 1.5 microgram/ kg subcutaneously, once weekly, in combination with weight adjusted Ribavirin.