fMRI will be performed on three occasions: i) at the baseline, ii) 1 week after optimizing the treatment, iii) 8 weeks after optimization An fMRI block design with presentations of angry and fearful facial expressions interleaved with a sensorimotor control task will be used to elicit activations in amygdala. This paradigm of perceptual processing of facial expressions of negative emotions has been shown to effectively and consistently activate amygdala in previous studies (Hariri et al., 2002). The paradigm consists of a total of 6 runs and during each run, 3 blocks of emotional task interleaved with 4 blocks of sensorimotor control task will be presented. During the emotion task, subject will view a trio of faces and select one of two faces that expresses the same emotion as the target face in the top. Each emotion block will consist of 6 images, three of each gender, and target affect (angry and fear). Each facial stimulus will be presented for 5 seconds. The identity of all three faces will be always different. During the sensorimotor control task, subjects will view a trio of geometric shapes (circles, vertical and horizontal ellipses) and select one of two shapes that matches the target shape. Each control block consists of 6 different images, and each image will presented for 5 seconds. Accuracy and reaction time will be recorded during all scans.