− hypersensitivity to rosiglitazone, glimepiride, other sulphonylureas or sulphonamides or to any of the excipients − cardiac failure or history of cardiac failure (NYHA class I to IV) − an Acute Coronary Syndrome (unstable angina, NSTEMI and STEMI) (see section 4.4) − hepatic impairment − severe renal impairment i. e. creatinine clearance less than 30 ml/ min (including renal dialysis). − insulin dependant diabetes − diabetic ketoacidosis or diabetic coma.