4. Patient has taken the anti-emetic agents within the last 48 hours prior to the start of treatment with study drug: (1). 5-HT3 antagonists (ondansetron, granisetron, dolasetron, tropisetron, etc.). Palonosetron is not permitted within 7 days prior to administration of investigational product; (2). Phenothiazines (prochlorperazine, fluphenazine, perphenazine, thiethylperazine, chlorpromazine, etc.); (3). Benzamides (metoclopramide, alizapride, etc.); (4). Domperidone; (5) Cannabinoids; (6) NK1 antagonist (aprepitant); (7) Benzodiazepines (lorazepam, alprazolam, etc); (8) herbal medications or preparations in doses designed to ameliorate nausea or emesis