Hyper-reflexia, spasms and loss of motor coordination are common impairments in individuals with SCI. Though not thoroughly understood, recent studies suggest that persistent inward currents (PICs) in motoneurons play an important role in generating hyper-reflexia and involuntary spasms (Gorassini et al. 2004; Nickolls et al. 2004; Norton et al. 2008; Thomas et al. 2002). Animal models of chronic spinal cord injury point further to the differential involvement of increased sodium and calcium PICs in prolonged reflexes associated with spasticity (Harvey et al. 2006; Li and Bennett 2003; Li et al. 2004a; Li et al. 2004c). In addition, oral administration of the drug Rilutek®, a selective, progressive persistent sodium current inhibitor, has been shown to decrease flexion withdrawal responses in individuals with chronic SCI (Theiss et al. 2008), presumably because of the reduction of persistent sodium currents in participating neurons.