3. Renal function: serum creatinine (Cr) ≤ 1.5 × ULN, or creatinine clearance rate (Ccr) ≥ 40 mL / min (calculated using Cockcroft / Gault equation) Female：CrCl= (140-Age) x Weight(kg) x 0.85 72 x Serum creatinine (mg/dL) Male：CrCl= (140-Age) x Weight(kg) x 1.00 72 x Serum creatinine (mg/dL)