The study is comprised of validated methods. Overall society, patients and future patient will benefit from the new insights into liver physiology in the state of obesity and diabetes before and after bariatric surgery. Future patients will also benefit from the new insights into the effects of the gastric sleeve surgery that entails less risk for complications. This can lead to improved treatments and more carefully selection of patient elective for surgery. The overall benefits for patients, future patients and society outweigh the risk and side effects the subjects endure.