Laboratory abnormality Λ Significantly associated with Extavia treatment for patients with first event suggestive of MS, p < 0.05 * Significantly associated with Extavia treatment for RRMS, p < 0.05 ° Significantly associated with Extavia treatment for SPMS, p < 0.05 § Injection site reaction (various kinds) comprises all adverse events occurring at the injection site, i. e. the following terms: injection site haemorrhage, injection site hypersensitivity, injection site inflammation, injection site mass, injection site necrosis, injection site pain, injection site reaction, injection site oedema, and injection site atrophy & “ Flu-like symptom complex” denotes flu syndrome and/ or a combination of at least two adverse events from fever, chills, myalgia, malaise, sweating.