The aim is to test if serum level of myokines are associated with protein energy wasting, inflammation and atherosclerotic vascular disease among Taiwanese dialysis patients. Some novel myokines levels, anthropometric parameters, cardiovascular risk factors, and presence of endothelial dysfunction will be examined in 250 subjects. The distribution of some recently identified myokines such as irisin, myotatin etc levels will be studied and correlated markers of malnutrition, endothelial dysfunction, inflammation and insulin resistance. In the present study, the investigators will further follow and investigate whether serum myokines levels are associated with long-term mortality from all causes and from cardiovascular disease.