1. Inclusion Criteria 1）HCC (confirmed by pathology or meet clinical diagnostic criteria), 2）The patients are not candidates for curative surgery, which should be determined in consultation with two oncology surgeons of the same center, 3）Tumor was confined in intrahepatic, without extrahepatic metastasis and macro-vascular invasion (secondary vascular branches or below it), and the number of tumor was≤3 , 4）Child-Pugh A，normal renal function including serum creatinine and urea nitrogen level, white blood cell count >3×109/L、Hb>90g/L、PLT>50×109/L, 5）The score of Eastern Cooperative Oncology Group(ECOG): 0-2, 6）The estimated survival time > 3 months, 7）Without midsection history of radiation therapy, 8）Informed consent was signed, 9）Age: from 18 to 75 years old.