NO16966 This was a phase III randomised, double-blind (for bevacizumab), clinical trial investigating Avastin 7.5 mg/ kg in combination with oral capecitabine and IV oxaliplatin (XELOX), administered on a 3- weekly schedule; or Avastin 5 mg/ kg in combination with leucovorin with 5-fluorouracil bolus, followed by 5-fluorouracil infusional, with IV oxaliplatin (FOLFOX-4), administered on a 2-weekly schedule.