Moreover, studies in endogenous hypergastrinemia support an incretin effect of gastrin in man. All the basic research shows gastrin has a significant role in BG control by Beta cell proliferation, increase insulin secretion particularly post prandial peak and incretin like action. The findings of this study provide modest support for the proposition that PPIs may be a useful adjunctive therapy for type 2 diabetes. The postulated mechanism for this effect is PPI causing elevation of serum gastrin, enhancing pancreatic β-cell function, and stimulating increased insulin secretion. Proton pump inhibitors (PPIs) can raise serum gastrin concentration significantly and therefore, affect to glucose metabolism through promoting b-cell regeneration/expansion and also enhancing insulin secretion.