There are four operating stages depending on the symptoms of patients with heart failure, according to the classification in NYHA (New York Heart Association). At the operational stage I patients have symptoms of heart failure at a high level of exercise, beyond the ordinary. In stage II, the symptoms appear in a regular exercise level at stage III in small fatigue, while in stage IV symptoms occur at rest, so that patients are unable to look after themselves. Medication and diet can alter the operating phase which is the patient, without any significant change occurs in ventricular performance. It is particularly interesting that there is little correlation between symptoms and systolic left ventricular performance as expressed by the ejection fraction. Thus, patients with low ejection fraction <25% can be virtually asymptomatic, while others slightly influenced ejection fraction have serious discomfort. Changes of abdominal diatasimotitas of pericardial voltage, any valvular deficiencies and especially the function of the right ventricle are those factors which together with systolic left ventricular performance determine the occurrence or not of the symptoms of heart failure patients. In heart failure the function of the left ventricle is gradually worsening even in the absence of new effect damaging agent. This is the famous remodeling (Cardiac Remodeling) of the left ventricle, during which the investigators dilatation, hypertrophy and more spherical the shape. Thus, the mechanical performance of the ventricle decreases, increasing the mitral insufficiency due to distension of the mitral annulus, and increases the parietal stress. Ventricular remodeling contribute to continuous deterioration of symptoms, despite any treatment. The activation of the neurohormonal system proved to be the most important factor in why the cardiac remodeling and the unfavorable development of heart failure. Patients with heart failure have in their plasma levels of noradrenaline, angiotensin II, aldosterone, endothelin and cytokines which may act deleteriously on the structure and functioning of the heart. The mobilization of neurohormonal mechanisms in heart failure causes fluid retention and sodium, peripheral vasoconstriction, myocardial fibrosis and toxic effect on myocardial cells, creating a vicious cycle of deteriorating architecture and performance of the failing heart.