- If a subject is currently taking an ACE inhibitor, the study team will instruct the subject to HOLD their ACE inhibitor the following day. The subject would then start the study medication at least 36 hours after the missed dose of ACE inhibitor. For example, if study visit is on day 1, subject will HOLD ACE inhibitor morning of day 2, and start taking assigned study medication on study day 3 in the evening. Subjects will continue on their current treatment for their heart condition except for their ACE inhibitor.