incontinence • Clinical documentation for metered dose inhalers • Biostatistical/methodological guidelines (adjustment for multiplicity and related topics, missing data,* choice of delta, validity and interpretation of meta-analyses and one pivotal trial,* adjustment for baseline covariates) • Antimicrobial resistance • Thrombolytic treatment of acute myocardial infarction – Development of guidelines through multidisciplinary groups: • Comparability of medicinal products containing biotechnology-derived proteins