Pharmacokinetics of toremifene were investigated in an open study with four parallel groups of ten subjects: normal subjects, patients with impaired (mean AST 57 U/ L - mean ALT 76 U/ L - mean gamma GT 329 U/ L) or activated liver function (mean AST 25 U/ L - mean ALT 30 U/ L - mean gamma GT 91 U/ L - patients treated with antiepileptics) and patients with impaired renal function (creatinine: