Although the proposed study is exploratory in intent and does not require a formal power statement, we can nonetheless estimate power for the primary outcome of no central sensitization in patients with seborrheic dermatitis versus controls for the planned sample size of 20 subjects. The expected average mean score for a patient with central sensitization is 3 out of 10 and for a control patient 1 out of 10 with a standard deviation of 1. Therefore, for there to be no difference between both groups, we would expect both groups to have a mean score of 1 with a standard deviation of 1. In this case, if there is truly no difference between the control and experimental group (ie, no central sensitization), then 36 total patients (18 per group) are required to be 80% sure, 40 total patients (20 per group) are required to be 85% sure, and 44 total patients (22 per group) are required to be 90% sure, that the 90% two-sided confidence interval will exclude a difference in means of more than 1. We feel that in this instance, certainty over 80% will be clinically meaningful and have opted for 40 instead of 36 to better ensure the date achieves at least 80% certainty.