If the rate of increase in haemoglobin exceeds 2 g/ dl (1.25 mmol/ l) per month or the haemoglobin level exceeds 13 g/ dl (8.1 mmol/ l)m, the dose adaptation detailed in section 4.2 should be thoroughly performed to minimise the risk for thrombotic events (see section 4.2 Treatment of patients with chemotherapy induced anaemia - Dosage adjustment to maintain haemoglobin concentration between 10 g/ dl - 12 g/ dl).