− Initiation of treatment in pregnancy (see section 4.6). − Patients with a history of hypersensitivity to natural or recombinant interferon beta, human albumin or to any of the excipients. − Patients with current severe depression and/ or suicidal ideation (see sections 4.4 and 4.8). − Patients with decompensated liver disease (see sections 4.4, 4.5 and 4.8).