We and others have shown common SNPs at the chr4q25 locus are associated with increased risk of AF and modulate symptomatic response to AADs. Furthermore, our preliminary data suggests that there is a differential response to class I vs. class III membrane-active drugs. Here, we propose a pilot study to obtain preliminary data regarding AF burden in patients receiving AADs and to demonstrate feasibility for a future study to test the hypothesis that chr4q25 risk SNPs modulate differential response to AADs in patients with frequent symptomatic paroxysmal AF using reduction in mean AF burden as a metric of drug efficacy. Therefore, the Specific Aim of this pilot/feasibility study is to obtain preliminary data regarding AF burden in patients receiving AADs and to demonstrate feasibility for a future study to test the hypothesis that chr4q25 SNPs modulate differential response to class I vs. class III AADs in patients with frequent symptomatic AF.