Measure of daily functions The Lawton's Instrumental Activities of Daily Living (IADL) will be used to assess complex activities of daily functions that are impaired early in patients with SVD. It take about 10 minutes to administer and contains 8 items including ability to use telephone, shopping, food preparation, housekeeping, laundry, taking transportation, handling medications and finances. It is has been used as a primary outcome instrument in the Pan-European Leukoaraiosis and Disability in the Elderly Study in SVD.