uncontrolled diabetes mellitus, cardiac failure (The New York Heart Association [NYHA] Functional Classification ≥ Class III), myocardial infarction, cerebral infarction, unstable angina, arrhythmia requiring treatment, coronary/peripheral bypass surgery, pulmonary thrombosis, uncontrolled deep vein thrombosis, clinically severe thromboembolic event, or autoimmune disease requiring treatment. Has a history of myocardial infarction and unstable angina within 6 months before registration; symptomatic congestive heart failure (CHF; NYHA classes III-IV); congenital long QT syndrome; or ventricular arrhythmia requiring treatment.