Metabolomics. Fasting blood and urine (second void of the morning) samples will be collected before and after the 12 week diet and exercise intervention as well as every 2 weeks during the 12 week intervention, and monthly during 6 month follow-up. Our project will use the metabolomics database developed at the NMRFAM at UW-Madison and made freely available through the BMRB59 at (www.bmrb.wisc.edu/metabolomics).