The single-dose pharmacokinetics of nevirapine have been compared in 23 subjects with either mild (50 ≤ CLcr < 80 ml/ min), moderate (30 ≤ CLcr < 50 ml/ min) or severe renal dysfunction (CLcr< 30 ml/min), renal impairment or end-stage renal disease (ESRD) requiring dialysis, and 8 subjects with normal renal function (CLcr> 80 ml/ min).