Group 1 (ADT-Naïve): Patients who have not received LHRH analogue, LHRH antagonist or any anti-androgen for metastatic disease. Prior use of androgen deprivation therapy in the (neo)adjuvant, salvage, or biochemically recurrent setting is allowed provided the last day of effective androgen deprivation was more than 12 months prior to study entry. Androgen deprivation therapy must be planned to start within 28 days of baseline tumor biopsy.