Rare (affects 1 to 10 users in 10,000): • Inability to reach orgasm, menstrual disorder • Dandruff • Drug allergy, coldness in arms and legs, lip swelling, lip inflammation • Glaucoma, reduced visual clarity, eyelid margin crusting, eye rolling • Lack of emotion • Change in consciousness with increased body temperature and twitching of muscles, edema all over the body, drug withdrawal syndrome, body temperature decreased • Fast shallow breathing, trouble breathing during sleep, chronic otitis media • Obstruction of intestine, • Reduced blood flow to the brain • Decrease in white blood cells, inappropriate secretion of a hormone that controls urine volume • Breakdown of muscle fibers and pain in muscles (rhabdomyolysis), movement disorder • Coma due to uncontrolled diabetes • Yellowing of the skin and the eyes (jaundice) • Inflammation of the pancreas.