Anaesthesia will be induced with propofol (1.0-1.5 mg/kg), fentanyl (3-10 μg/kg), and cisatracurium (0.2 mg/kg). It will be maintained with sevoflurane (target BIS value 40-50) 11, and fentanyl (0.05-0.1 μg/kg/min). Patients will receive tranexamic acid (10 mg/kg after anaesthesia induction plus the same dosage in the CPB prime), depending on their kidney function.