Recurrent abdominal pain has long been acknowledged to be one of the most common chronic pain entities in children. In the US, ~13-17% of school-aged children and adolescents report abdominal pain that occurs at least weekly and 21% of these report pain severe enough to interfere with daily activities. (1) For most of these children (~90%), no specific organic disease is found. However, these children experience decreases in quality of life that are comparable to children with identifiable organic diseases such as inflammatory bowel disease and gastro-esophageal reflux. (2) In addition, children with no identifiable organic disease do not appear to get better on their own and often continue to have problems with abdominal pain and associated symptoms into adulthood. (3,4)