Ventilatory capacity will be assessed by spirometry recorded by the EasyOne™ PLUS spirometer to record average FEV1 over three reproducible trials. Kidney function will be assessed by obtaining a basic metabolic panel (BMP) at baseline and follow up. Blood pressure and pulse will be measured in the right arm, using an automatic Omron device, with the participant in a seated position after having rested quietly for 5 minutes. Subjects will sit with feet flat on the floor and legs uncrossed and will be asked not to talk during the rest period or during the measurement. Appropriate cuff size will be used. Systolic and diastolic blood pressure will be defined as the average of two repeated measures. Interleukin-6 will be assessed in plasma samples that will be measured in blood drawn after an overnight fast at baseline and follow up. Finally, serum and plasma will be collected and stored for later assessment of biomarkers to identify potential mechanisms underlying the effects of the intervention on muscle and bone loss during weight loss.