- Cardiovascular disease with clinical significance (such as active), including but not limited to transient ischemic attack (< 6 months before selected), myocardial infarction (< 6 months before selected), unstable angina, the classification of the New York heart association class II or higher congestive heart failure, needing drug treatment during the study period, which may interfere with the treatment, serious arrhythmia that drugs cannot control;