Stop taking Activelle If you are experiencing any of the following conditions below, stop taking Activelle, and contact your doctor immediately: • If you get a migraine-type headache for the first time • If you develop yellow skin or eyes (jaundice) or other liver problems • If your blood pressure goes up while you’re taking Activelle • If you become pregnant • If any of the conditions listed in section 2,“Do not take Activelle”, occur.