Therefore, terfenadine is contraindicated in the following conditions: − significant impairment of hepatic function (e. g. in patients with jaundice, hepatitis, cirrhosis). − concomitant treatment with azole antifungals/ antimicrobials (including topical antifungals) − concomitant treatment with macrolide antibiotics (including topical macrolide antibiotics) − concomitant treatment with mibefradil dihydrochloride − concomitant treatment with other medicinal products known to inhibit hepatic metabolism of terfenadine.