The clearance of total doxorubicin was 5.1 ± 4.8 l/ h and the volume of distribution at steady state (Vd) was 56.6 ± 61.5 l whereas after conventional doxorubicin, clearance and Vd were 46.7 ± 9.6 l/ h and 1,451 ± 258 l, respectively.