Isotretinoin is contraindicated in women of childbearing potential unless all of the following conditions of the Pregnancy Prevention Programme are met: • She has severe acne (such as nodular or conglobate acne or acne at risk of permanent scarring) resistant to adequate courses of standard therapy with systemic antibacterials and topical therapy (see section 4.1 “ Therapeutic indications”). • She understands the teratogenic risk. • She understands the need for rigorous follow-up, on a monthly basis.