Reproduction is authorised provided the source is acknowledged. • the combination of doxorubicin and cyclophosphamide for 12 weeks, followed by Taxotere/ Docetaxel Winthrop for 12 weeks, either alone or in combination with trastuzumab; • the combination of Taxotere/ Docetaxel Winthrop, trastuzumab and carboplatin for 18 weeks.