Do not start taking Activelle: • If you are allergic (hypersensitive) to estradiol, norethisterone acetate or any of the other ingredients of Activelle (listed in section 6,“Further information”). • If you have or have had breast cancer, or if it is suspected • If you have cancer of the womb lining (endometrium), or if such an oestrogen dependent cancer is suspected • If you have any vaginal bleeding, which has not been diagnosed by your doctor • If you have endometrial hyperplasia (excessive growth of the womb lining) that is not being treated • If you have a blood clot (like deep vein thrombosis or lung embolism) or previously have had a blood clot without obvious cause, e.g. in connection with surgery or pregnancy • If you have recently had a heart attack, stroke, or have angina • If you have or have had a liver disorder and your liver tests have not returned to normal • If you have porphyria (a liver enzyme disease)