With regard to the safety and use of ciprofloxacin in children, see also section 4.4 • children and growing adolescents except for the treatment of acute pulmonary exacerbations of cystic fibrosis in children aged 5 to 17 years. • pregnancy and lactation • patients with a history of tendon disorder related to fluoroquinolone administration • Concurrent administration of ciprofloxacin and tizanidine