Renal patients In patients with severe renal impairment (creatinine clearance less than 30 ml/ min), the dose of methylnaltrexone bromide should be reduced from 12 mg to 8 mg (0.4 ml RELISTOR) for those weighing 62 to 114 kg, or from 0.15 mg/ kg to 0.075 mg/ kg for those whose weight falls outside the 62 to 114 kg range (see section 5.2).