- each center's data are the property of the same center; each investigator has free access to its own data and can divulge them, but without associating them with the study TRAJECTORIES. The Steering Committee alone is responsible for the whole, appropriately codified database, and can freely accede to it. Each investigator will be allowed to propose ancillary substudies/subanalyses which are to use data already provided in accordance with the protocol. Proposals have to be submitted to and approved by the Steering Committee;