All enrolled study subjects, after cessation of therapy, will be evaluated at baseline, week 6, 12, 18, 24, 36 and 48, with liver biochemistry, alpha-fetoprotein, HBV DNA, HBsAg and HBcrAg levels determined at each clinic visit. A regular 6-week follow-up will be in place for the first 24 weeks, since approximately 75% of all virologic relapse occurs in the first 24 weeks - the regular monitoring will allow detection of relapse at an early stage. In addition, a dedicated research assistant will follow-up all study subjects and assist on all monitoring logistics. A telephone hotline will be provided to all study subjects if they have any additional queries.