For the WP2, results will be described as mean±SD or median [IQR], according to the normality in data distribution, analyzed by the Shapiro-Wilk test. Effects of the PAEP on the group of patients receiving the combined treatment (PR+PAEP) will be assessed by comparing PAL before (Visit 1) and after 3 months of the beginning of PR (Visit 2) using a paired student t-test (or the correspondent test for non-normally distributed variables). Effects of the PAEP on the main outcome (physical activity levels) will be assessed by comparing the differences (post-pre PAEP) in physical activity levels between PAEP and Control by unpaired student t-test (or the correspondent Mann-Whitney test). Correlations of PADL with other variables will be assessed either by the Pearson's or Spearman's coefficients depending on the distribution of the variables. The level of significance for all comparisons will be set at p<0.05. Data will be analyzed using the statistical package SAS version 9.3 (SAS Institute Inc, Cary, NC, USA).