Clinical Outcomes: proportion of patients requiring treatment for a gout flare and tophi size change The proportion of subjects requiring treatment for a gout flare (APEX and FACT Study) was numerically lower in the groups that achieved an average post-baseline serum urate level < 6.0 mg/ dl, < 5.0 mg/ dl, or < 4.0 mg/ dl compared to the group that achieved an average post- baseline serum urate level ≥ 6.0 mg/ dl during the last 32 weeks of the treatment period (Week 20-Week 24 to Week 48 - 52 intervals).