The long-term goal of this research program is to improve education provided to African Americans and, thereby, increase rates of LDKT. The objective of this application is to determine the relative effectiveness of three strategies for increasing LDKT in African Americans. In a recently completed HRSA-funded (2002-2006) randomized clinical trial, we demonstrated that a home-based LDKT intervention program was superior to standard clinic-based education in increasing LDKT rates at one transplant center. The proposed study seeks to replicate and extend the evaluation of a home-based (HB) educational intervention in an African American patient population. The central hypothesis is that a HB intervention yields higher LDKT rates relative to other interventions in African Americans. This hypothesis has been formulated on the basis of strong preliminary data. The rationale for the proposed research is that, by identifying the interventions most likely to yield higher LDKT rates in African Americans, we can further develop and refine the interventional methodology that will allow the most effective education to be disseminated to all kidney transplant programs. We are especially well-prepared to conduct the proposed research due to the multidisciplinary nature of the research team, as well as the expertise and experience of the team in developing LDKT and live donation educational materials, implementing and evaluating novel LDKT interventions, conducting LDKT research with African Americans, and producing meaningful outcomes. Specifically, the research team includes investigators who are funded in the conduct of ESRD, kidney transplantation, and organ donation research and who are dedicated to the scientific advancement of LDKT. Also, the research will be conducted in an environment that is conducive to the successful completion of this project.