At the baseline, Structured Clinical Interview I and II will be performed to determine the DSM IV diagnosis of MDD and also to exclude other Axis I psychiatric disorders. Hamilton rating scale for depression (HRSD) (will be used to assess the severity of depressive symptoms (Hamilton 1960) and Hamilton anxiety rating scale (HAM-A) (Hamilton 1959) will be used to rate anxiety symptoms. Additionally, temperament and character inventory (TPI) (Cloninger et al 1994) and childhood trauma questionnaire (CTQ) will be administered to assess and control for the personality traits such as fear and anxiety and child hood abuse that are known to affect amygdala responses to fearful stimuli