2. RATIONALE AND OBJECTIVES CRH is considered to be a prominent mediator of stress responses in the brain-gut axis. In particular, stress-related activation of CRH receptors has been reported to produce alterations in gastrointestinal function. In a first study, the investigators studied the effect of CRH on esophageal sensitivity in healthy volunteers (HV). Preliminary results demonstrated that CRH-administration increased esophageal sensitivity (pain perception threshold) to mechanical stimulation of the esophagus. In the present study the investigators want to study whether exogenous CRH changes the response to mechanical stimulation through an effect on esophageal contractility. Therefore, the aim of this study is to investigate the effect of CRH-administration on esophageal motility during a standard high resolution manometry (HRM) in HV.