Subjects will record the following information in a Daily eDiary starting at the first Screening visit: the amount of low back pain while standing, walking, and/or in motion during the preceding 24 hours (using a 100 mm visual analog scale [VAS]), Oswestry Low Back Pain Disability Questionnaire, the times and number of sprays for each administration of study medication (starting at the first screening visit), the times when the subject washes his/her low back and/or takes a shower, the number of tablets of rescue medication taken that day and the times taken, the reason for taking the rescue medication (eg, low back pain, headache, knee pain, hip pain), any other concomitant medications taken that day, the use of Curél Itch Defense Lotion, and any AEs occurring that day. The study treatment may cause dry and/or itchy skin; therefore, Curél Itch Defense Lotion (available at any pharmacy) can be applied to treat the affected area and recorded in the diary.