- Patients taking any agent reported to have symptom relief for arthritis or be a disease/structure modifying drug (e.g. doxycycline, long-term tetracycline, s-adenosylmethionine [SAM], dimethyl sulfoxide [DMSO], dietary supplements or any herbal remedy taken for arthritic and joint conditions within the past month. Exceptions are products containing glucosamine/Chondroitin/methylsulfonylmethane (MSM) if stable for 4 months prior to Screening and remain stable throughout study and fulfill the VAS pain entry criteria).