Demographic and socio-economic characteristics will be recorded. History of fever and antimalarial drug use will also be recorded. Women will be randomly allocated to the SP + CQ (CQ 300 mg weekly) or SP + placebo group (IPT twice during pregnancy). All women will receive supplementation of 120mg elementary iron daily and 5mg folic acid weekly. IPT with SP will be started in the second trimester and a second dose in the third trimester. Women will be encouraged to deliver in health units and TBAs will be involved to follow-up of those who deliver in the villages. Health workers will liaise with TBAs to collect information and samples (birth weight and blood slides). The general health conditions of the mothers (including Hb, clinical malaria, body temperature, body weight, foetal heart sound, urine analysis) will be assessed throughout pregnancy. Clinical malaria cases will be treated according to national guidelines with CQ and SP. In case of treatment failure quinine will be given as second line treatment.