The following is a recommended premedication regimen: dexamethasone (8 - 20 mg) given orally (12 and 6 hours) or intravenously (30-60 mins) prior to Paxene, chlorpheniramine 10 mg intravenously or an equivalent antihistamine 30 to 60 minutes before Paxene and cimetidine (300 mg) or ranitidine (50 mg) intravenously 30 to 60 minutes before Paxene.