Since this is an observational study that has the aim to evaluate the effectiveness of conservative approaches after neoadjuvant therapy in terms of capacity preservation of organ, they were not given directions on the type of radio and/or chemotherapy treatment. Patients will be enrolled in the study only when patients are candidates (as shown in the studies published on the subject) to a conservative approach. The "registration" of all patients is only meant to evaluate how many patients are potentially candidates for conservative treatment who are undergoing neoadjuvant treatment (secondary endpoint of study). The collection of data concerning the staging of the tumor and basal schemes neoadjuvant therapy aims to identify what type of cancer and what type of neoadjuvant therapy are associated with a higher number of pathological complete responses (secondary endpoint). Finally, for patients who show a cCR, is leaving the ability to run both LE and wait-and-see approach, as the current state, there are no data indicating which option is best in terms of both oncological results and rate of organ preservation.