Study subjects The study is expected to run for about 3 years and patients will be followed for a period of 24 months. All consecutive patients presenting with HCC satisfying study inclusion and exclusion criteria will be approached for participation. At an average, about 200 patients with HCC are evaluated annually in the multi study centres. We anticipate that 60 patients would be eligible for the study of whom 40 would be recruited for the study. A total of 40 patients will be recruited from 2 - 3 centers in KSA (KSU, LDRC; KAMC-Riyadh). Of these 15 patients will be recruited from King Abdulaziz Medical City, Riyadh. Recruitment is planned to be completed in the first year of the study.