Subjects that take part in this voluntary study will undergo 6 clinic visits during the 8-week study period. The first visit may last up to 3 hours, with all other clinic visits lasting approximately 45 minutes. Once the consent form has been read and signed, subjects will be enrolled in the study. At the first visit, medical and psychiatric histories will be reviewed. All participants will undergo the standardized protocol for establishing depression, the Structured Clinical Interview for DSM-IV (SCID), in addition to being rated by symptom rating scales that include the Clinical Global Impression (CGI) and the Hamilton Depression Rating Scale (HAM-D (17-item). All participants will also undergo an entry interview that will include a psychiatric and substance use history (including data regarding use of alcohol, tobacco, and illicit substances). During the initial exam, vital signs (height, weight and blood pressure) will also be recorded for all participants. In addition, all subjects that are enrolled must have had a gynecologic exam within the past year, or if not, will be given a referral for such an exam. Blood (approximately 3 teaspoons) will be drawn for routine laboratory testing (thyroid function tests (TFTs) and complete blood count (CBC)) and a lipid profile. Blood will also be drawn (approximately 3 teaspoons) at the last visit for the purpose of repeating the lipid profile. Subjects will also complete the Greene Climacteric Scale (GCS), which is used to quantify the severity of perimenopausal somatic symptoms, including hot flashes.