Phospholipidosis (intracellular phospholipid accumulation) affecting a number of organs and tissues (e. g., liver, kidney, lung, thymus, spleen, gall bladder, mesenteric lymph nodes, GI-tract) has been observed in rats and dogs administered telithromycin at repeated doses of 150 mg/ kg/ day or more for 1 month and 20 mg/ kg/ day or more for 3-6 months.