- Major co-morbid conditions precluding full evaluation, i.e., active lung cancer, acute coronary syndrome, heart failure exceeding New York Heart Association class 2; a diagnosis of metastasized malignancy; renal failure in excess of creatinine clearance < 30 mls/min calculated by the Cockcroft-Gault formula, which would severely complicate administration of aminoglycosides and capreomycin, considered as the major second-line TB drugs; obesity (Body Mass Index >30 kg/m2); chronic liver disease - Child-Pugh class C;