• Hypersensitivity to lisinopril or to any other angiotensin converting enzyme (ACE) inhibitor. • Hypersensitivity to amlodipine or to any other dihydropyridine derivatives. • Hypersensitivity to any of the excipients. • Severe hypotension. • A history of angioedema relating to previous ACE inhibitor therapy. • Hereditary or idiopathic angioedema (see section 4.4). • Haemodynamically significant obstruction in the outflow tract of the left ventricle (aortic stenosis, hypertrophic cardiomyopathy), mitral stenosis or cardiogenic shock. • Heart failure after acute myocardial infarction (during the first 28 days). • Unstable angina pectoris (excluding Prinzmetal’ s angina). • Pregnancy and lactation (see section 4.6).