It must not be used in the following groups:  patients with an auto-immune disease (a disease caused by the body’ s own defence system attacking normal tissue);  patients who have an active infection at the operation site or have had repeated infections;  patients who do not have adequate skin covering or blood supply at the operation site;  patients who have received a medicine containing BMP in the past;  patients with cancer or being treated for cancer;  patients whose bones are still growing such as children and adolescents.