Duration of treatment and removal of subjects Patients will be followed for a period of 24 months. Patients removed from study for unacceptable adverse events will be followed until resolution or stabilization of the adverse event. Patients are to continue therapy with Sorafenib until • Disease progression • Until a criterion is met for stopping therapy like o Concurrent illness that prevents further administration of treatment o Unacceptable adverse events(s) o Patient decides to withdraw from the study o General or specific changes in the patient's condition render the patient unacceptable for further treatment in the judgment of the investigator. In the event of radiologic progression, patients may continue to receive the study drug. Decisions about continuing study medication will be made at the discretion of the investigator, based on the investigator's judgment about the patient's clinical status. In general, it is suggested that patients remain on Sorafenib if, in the opinion of the investigator, the patient may be benefiting from continuing on study drug Removal of subjects and the reason of the removal will be documented.