It can also be used in patients with severe rheumatoid arthritis who have not taken methotrexate before; • polyarticular juvenile idiopathic arthritis (a rare childhood disease causing inflammation of many joints) in children aged four to 17 years who have not responded adequately to or cannot take methotrexate; • psoriatic arthritis (a disease causing red, scaly patches on the skin and inflammation of the joints) in adults who have not responded adequately to other treatments; • severe ankylosing spondylitis (a disease causing inflammation of the joints of the spine) in adults who have not responded adequately to other treatments; • plaque psoriasis (a disease causing red, scaly patches on the skin) in adults with moderate to severe disease and in children from the age of eight years with chronic (long-term) severe disease.