This protocol will include fertile women who suffer from ovarian pathology without other medical disease and are scheduled to undergo bilateral oophorectomy associated with or without hysterectomy. Patients who suffer from uterine pathology and undergo hysterectomy only will serve as controls. Blood pressure and all biochemical characteristics will be measured one week before surgery and 1, 3, 6 and 12 months after operation. All individual measurements will be blinded as to the hysterectomized/oophorectomized status of the patients. The entire data group will be reported as mean ± SE. Differences in vascular parameters between oophorectomized women and controls and between values recorded prior to and following surgery will be assessed using paired and unpaired Student’s t-tests.