The following parameters (predicted mean ± SD) were estimated for a dose of 8 mg/ kg tocilizumab given every 4 weeks: steady-state area under curve (AUC) = 35000 ± 15500 h µg/ ml, trough concentration (Cmin) = 9.74 ± 10.5 μ g/ ml and maximum concentration (Cmax) = 183 ± 85.6 µg/ ml, and. the accumulation ratios for AUC and Cmax were small, 1.22 and 1.06, respectively.