Rationale for the study, potential risks and benefit In the immediate postoperative period following STN DBS, simplification of the medication regimen is advised, given the complexity of the interactions between stimulation and medication. Both L-dopa and DAs can be used, however, there are no formal studies examining which type of antiparkinsonian medication may be more effective and/or better tolerated following STN DBS. In spite of the need of simplification of the medication regimen after STN DBS in PD, to date there are no clinical trials specifically designed to compare the efficacy (in terms of motor and non-motor outcomes) and safety of L-dopa monotherapy versus DAs monotherapy following STN DBS.