After a Screening Period, a subject will be randomly assigned to 1 of 2 treatment groups in a 2:1 ratio of active: placebo (ie, 2 subjects to active treatment and 1 subject to placebo) and stratified evenly according to Modified Pfirrmann Grading system grade 3, 4, 5, or 6, gender, BMI (30≤vs.>30), and age (65≤vs.>65). Before the first screening visit, there is a pre-Screening Telephone Call or email interview, the Screening Period of at least 14 days up to 3 weeks will consist of two visits for the assessment of eligibility including radiographic evaluation of the low back. All tasks at screening visits and week 2, 5, 10, 15, and 20 visits are listed in Study Flow Chart of Double-blind Period and the open label period will be started from the Week 20 visit.