Side effects. No cases of death have ever been reported in studies of BCP. While the typical dose is 10g/day [8-10] doses as high as 10 g four times daily have been studied[11]. Adverse reactions have been few in number and slight in severity. In most clinical studies on the efficacy of bovine colostrum there have been no demonstrable adverse effects[9, 10, 12-15]. When they have occurred, they have mostly consisted of nausea, emesis, flatulence, and mild diarrhea[8, 11, 14, 16, 17]. In one study, transient moderate elevations in serum levels of hepatic transaminases were observed in volunteers who received bovine immunoglobulin concentrates prepared against E. coli (5/10) and rotavirus (2/10). This effect was attributed to diets high in protein provided at the hospital (13). More recently, bovine colostrum was well-tolerated in HIV-infected persons for the treatment of HIV-associated diarrhea (18).