There is an ongoing discussion on whether antibiotic regimens used for eradication and selective digestive tract decontamination (SDD) might lead to the emergence of multi-drug resistant bacteria.11 Emergence of resistance under long-term administration of SDD to ICU patients has been previously reported.12 However, a recently published meta-analysis, including 64 studies in ICUs, of which 47 were randomized controlled trials and 35 included data for the detection of antimicrobial resistance, no relation between the use of SDD and the development of antimicrobial resistance could be detected.13 Even without this information, the risk for emergence of resistance should be classified as very low, considering that patients will receive eradication treatment for the duration of only seven days. Nevertheless, the possible emergence of non-ESBL multi-drug resistant bacteria in the intestine will be assessed during the study intervention.