Statistical Analysis Sample Size The sample size calculation was based on the proportion of patients that remain episode-free after 12 months following a group intervention. Previous studies utilizing TAU exhibited a decrease of bipolar relapses in 30% of patients after a one-year follow-up. The present study anticipates a 55% success rate in prevention of mood relapses, during the same period, in patients assigned to the Cognitive Behavioral Rehabilitation. Thus, considering an 80% power to obtain a 5% significance, an estimated sample of 28 individuals per group, 56 in total, should be sufficient to achieve significant results. A previous study conducted by the same research team measured a drop-out rate of 10% in a one year follow-up, for this latter reason, the study will consist of 60 participants.