Currently, we are at the threshold of a new era, where the possibility exists of treating generalized psoriasis with absolute systemic safety and better efficacy than any systemic or biologic agent. This possibility can only become a reality with a "perfect storm," in which three storms collide. This "perfect storm" may achieve a result which no other therapy has yet achieved: a Psoriasis Area Severity Index (PASI)75 response in 100% of patients after only 4 weeks of therapy. The three "storms" include Clobex® spray, Vectical® ointment, and the excimer laser machine XTRAC® Velocity.