Open study of creatine in depression: A preliminary open study of creatine monohydrate (Roitman S, Green T, Osher Y, Karni N and Joseph Levine, submitted), suggested a statistically significant beneficial effect of creatine augmentation to antidepressant treatment in resistant major depression, but possible precipitation of a manic switch in resistant bipolar depression (see table 1 for results). Adverse reactions were mild and transitory and included mild nausea and flatus.