Secondary analyses. We plan to perform three secondary analyses. First, we will examine the influence of single SNPs of stronger effect on QT response to moxifloxacin. As power calculations, and study enrollment are based on the aggregated genotype score, we expect these secondary analyses to be underpowered. Second, if we observe a significant difference in QT response between top and bottom quintiles of QT genotype score, we will examine the influence of deciles on observed results comparing the 9th (80-90%ile) and 10th deciles (>90%ile) of score to the bottom decile or quintile, although given the composite nature of the genotype score and additive nature of the variants, we do not expect a threshold effect. Lastly, we will determine the impact of baseline QTc on QT response and test whether additional adjustment for baseline QTc alters any observed effect of genotype score on QT response to moxifloxacin.