Data Management and Analysis: Differences in hs-CRP, TNF-α and IL-6 levels between the 3 vascular access groups for all time periods (baseline, 1 week, 1, 3, 6,12 months) will be analyzed using a random effects (mixed) model, with time as a random effect. A Power analysis was performed by Kathrine Freeman, PhD in the Department of Biostatistics and Epidemiology at Montefiore Medical Center, using multiple comparisons between groups. We hypothesize a 100% increase in hsCRP level from baseline in the catheter group and a 10% increase in the AVF group. We predict that the AVG group will have an increase in hs CRP between 10-100%. The initial power analysis (80%, 2-tailed α=0.05) predicted that 51 subjects per group would be needed. Anticipating a 20% dropout rate per year, we will recruit 61 subjects will be required in each group. All hsCRP data will be transformed, most likely using a log scale, as per prior studies and upon review of the distribution of the data. Dunnett's multiple comparison procedure will be performed for the 2 contrasts (each group, ie. the AVF and AVG groups, compared with the tunneled catheter group. A multivariate analysis using a mixed effects model will be performed to determine the factors related to a change in CRP level at baseline and at 1 week, 3, 6, 12 months. Patient and access survival will be analyzed using Kaplan-Meier method and Cox proportional hazards regression analysis.