The standard initial and maintenance immunosuppressive regime is Tacrolimus, Mofetil Mycophenolate and prednisone. The initial Tacrolimus doses are aimed to obtain blood trough levels of 10 to 15 ng/mL, until the 3rd month post-transplant; subsequently and in the absence of AR during the first trimester (clinical or by protocol biopsy), the trough levels are maintained between 8 and 10 ng/mL throughout the first year post-transplant. The maintenance dose of prednisone is 5 mg daily and that of Mofetil Mycophenolate is 1-1.5 g daily.