Critically ill patients represent an absolutely discrete group because they may have acute decrease in renal function, multiple organ failure and they often receive multiple potentially nephrotoxic agents like antibiotics, vasoconstrictives, NSAIDs etc. Critically ill patients frequently required radiographic studies with contrast agent administration in order to improve diagnostic accuracy in the detection of abscesses, or in the diagnosis of suspected embolism. Radiographic studies are often done on an emergent or urgent basis so there is not enough time for patients to receive prophylactic regiments. Despite improvements in supportive care, acute renal failure increases the morbidity and mortality rates in critically ill patients.