For the major end point change in NORRISK Score (3) a systematic review of the literature to estimate sample size for a power estimate was done in association with a pilot study to estimate the variability of the score. The outcome variable is difference in risk score between baseline and three years follow-up. Considering the analysis of the pilot study, the investigators estimated the variability of the score difference (delta) of NORRISK to be standard deviation = 6.18%. As the median age of this sample was 51 years it is considered a change in the probability of ten years cardiovascular death of 1.5% to be clinically interesting. For a power of 90% and a type-I error of 5% the study will need two times 358 patients. Accepting a 10% dropout in the actual population, the corrected sample size will be two times 394. A total of 800 patients, two times 400, could be enough to pinpoint substantial risk change between baseline and three years follow-up for the NORRISK score.