Percutaneous coronary intervention (PCI) is the standard of care for patients with acute coronary syndrome (ACS). Approximately 1,200,000 PCIs were performed in 2002 in the United States. Drug-eluting coronary stents have nearly abolished the clinical problem of in-stent restenosis at a cost of increased susceptibility to in-stent thrombosis, a catastrophic event associated with a 6-month mortality rate of 8.9% and a myocardial infarction rate that exceeds 50%.