Randomisation schedules will be in blocks, with the proposed treatment delivered in writing in sequentially numbered, opaque, sealed envelopes. If inferiority of efficacy is demonstrable on preliminary statistical analysis, the trial will be stopped prematurely to prevent harm to patients. We aim to perform a preliminary analysis of the pooled data at 6/12/18/24 months or when 100/150/200 patients have been entered into the trial; whichever comes first will prompt preliminary analysis. Each adverse event will be included in the electronic file of each patient in the study. The data will then be communicated with the PI at each site participating in the study. In the event of one technique being of greater risk to patients, the lead center in Dublin, Ireland will terminate the study prematurely. Similarly, in the event of a PI in the study being unhappy with the outcomes of the study, they are free to withdraw from the trial at any time. This withdrawal will be reported in publishing the data.