At baseline the following data will be obtained retrospectively from medical records for each patient and will be recorded in the electronic case report forms: demographics, diagnosis, agitation information of current/previous episode (date/time of the onset, time to improvement and patient status rate at 2h of ADASUVE® administration [CGI-I scale]), respiratory disease history and risks factors, co morbidities/medical history (non-respiratory), concomitant medications, previous ADASUVE® treatment (date and dosing data).