Recently, some clinical trials have demonstrated that the angiotensin converting enzyme inhibitors (ACEIs) and ARA II, reduce the risk of presenting new cases of DM2 as compared with other antihypertensive therapies. However, no clinical trials have addressed specifically the study of the effects of the ARA II in the improvement of the dysglycemia and in the prevention of the diabetes type 2. Additionally, the treatment with ACEI and ARA II has shown to improve the resistance to peripheral insulin both in animal models and clinical studies. The mechanism by which the renin-angiotensin-aldosterone system blockade has a beneficial effect on the responsiveness to insulin has not been totally cleared. In obese Zucker-type rats, it was demonstrated that the chronic treatment with a selective ARA II receptor produced a significant increase in the GLUT 4 transporter expression in skeletal muscle and a reduction in the concentrations of plasma fatty acids associated with an improvement of the responsiveness to insulin.