A personalized genetic approach to toxicity prevention would be important because cardiotoxic drug response is not specific to a single class of drugs; risk prediction for arrhythmogenicity can be applied across medications used in a variety of conditions. Narrowly, this research can enable drugs with currently marginal risk/benefit profiles to be brought to market, sparing those at-risk and providing access to new therapies for those who are not. From a public health perspective, it will reduce potentially fatal toxicity and thus improve human health through identification of particular at-risk individuals. But more broadly the application of human genetics requires rigorous definitions of association and well-powered and -designed tests of pharmacogenetics before broad application can be considered.