Recently, we have demonstrated that the Colombian population with a lower abdominal circumference than those reported in Caucasian populations presented an increased risk of developed metabolic syndrome and coronary artery disease. Moreover, abdominal obesity in our population is associated with higher levels of inflammatory markers, as C-reactive protein (CRP) and proinflammatory cytokines. Nowadays, the relationship between abdominal obesity, inflammation, insulin resistance, diabetes mellitus type 2, metabolic syndrome and cardiovascular disease is a crucial aim of research, especially in populations as the Colombian, that is in high risk of being affected by the epidemic of diabetes mellitus and cardiovascular disease. The occurrence of DM2 is associated with a 2 to 4 fold increase in the risk of developing coronary disease. The diabetic patients that present unstable angina have a greater risk of developing acute myocardial infarct (AMI) and the diabetic patients with AMI have more risk of death than the non-diabetic patients. Additionally, the subjects with DM2 have an increased risk of experiencing cardiovascular events (1.5 to 3 times), and greater recurrence and mortality for these causes. The incidence and severity of the peripheral arterial disease are also increased from 2 to 4 times in diabetic patients.