CR, disappearance of all nontarget lesions and normalization of tumor markers, confirmed at ≥4 wk; PD, unequivocal progression of nontarget lesions or appearance of new lesions; non-PD: persistence of one or more nontarget lesions or tumor markers above normal limits; PD must be ''unequivocal'' in nontarget lesions (e.g., 75% increase in volume); PD can also be new ''positive PET'' scan with confirmed anatomic progression. Stably positive PET is not PD if it corresponds to anatomic non-PD