PLAN OF THE STUDY All consecutive patients who present in Pediatric Emergency and OPD in Advanced pediatric Centre with suspected Infantile tremor syndrome will be screened for inclusion in the study. Those found eligible would be included after an informed consent. Baseline clinical and demographic profile will be recorded on a proforma..The study aims at assessment of vitamin B12 status in children with ITS. The various manifestations of the syndrome, the presentations, the clinical picture, the development profile, various haematological and biochemical markers would be studied in a detailed manner and recorded on a proforma (annexure).