The use of external irradiation has also been reported in the treatment of symptomatic systemic amyloidosis. In published peer reviewed articles treatment sites have include trachea-pulmonary, ocular, laryngeal and for use as a conditioning agent for autologous BMT in patients with systemic amyloidosis. These reports used external beam irradiation that ranged from 5.5 - 45 Gy and detail durable local control with these doses.