This phase will last 10 months. During the follow-up, the patients will be seen by the research group in 4 opportunities. The first visit will take place the day after the end of the treatment (day 21) in which new blood samples will be taken for biochemical determinations. The second, third and fourth visits will be realized on day 45, 90 and 180 respectively. During these visits the healing process of the ulcer, the presence of recidivisms and/or reinfection and the health of the participants will be assessed. The evolution of the ulcers will be photographically registered.