Although the mechanisms are still speculative, the beneficial effects of the renin-angiotensin system blockade, demonstrated in several studies such as HOPE, LIFE, VALUE, on the responsiveness to insulin and in the prevention of the development of new cases of DM2, suggest that angiotensin II produced in the adipocytes of obese subjects is associated to the insulin resistance syndrome and supports the execution of clinical trials oriented to establish the beneficial effect of ARA II in the prevention of DM2 in susceptible individuals coming from populations at high risk of developing CVD and diabetes mellitus, as the Colombian one.