Patient level QA Radiotherapy plans and dose-volume histogram (DVH) data for the first two patients on trial from a center will be submitted for central review, if possible in electronic form. During the period when a center is accruing patients for the trial, the Data Center will randomly select a subset of patients (5-10%, a smaller proportion reviewed for highly accruing centers) for a 'crossed' review where 3-4 centers will review cases. It is expected that the total number of cases reviewed for HYPNO will not exceed 50.