One subject group will lose 10% of initial body weight using a VLCD. There are no risks for the subjects in consuming the VLCD (Modifast, together with the recommended fruit and vegetables) as the macronutrient composition and vitamins/minerals content meet the Dutch recommended daily allowance. This VLCD will demand some energy from the subjects at home. However, due to extensive experience with VLCD in our laboratory and due to the benefit of weight loss for the participants we anticipate enough will-power to complete these 2 months VLCD.