The FSIGT was performed 72 hours following the baseline CET after an overnight fast. Intravenous cannulas were placed in the antecubital vein of each arm. A glucose injection (500mg/kg as a 50% solution) was given over 1 minute starting at time 0 minutes. Blood samples for the determination of glucose and insulin were taken at -10, -5, 2, 3, 4, 5, 6, 8, 10, 12, 14, 16, 19, 22, 24, 25, 27, 30, 40, 50, 60, 70, 80, 90, 100, 120, 140, 160, and 180 minutes following the conclusion of the glucose infusion. Twenty minutes following the start of the intravenous glucose, 0.04 U/kg of human insulin (Novolin R) was injected. Insulin sensitivity was determined using the validated MINMOD-IS technique. The MINMOD-IS determination was made by one of the investigators (DF) blinded to the patient's group allocation.