Vasopressor agents are commonly used to correct hypotension in patients with acute circulatory failure. Their variable alpha, beta, or dopaminergic receptor stimulation, may result in different hemodynamic and metabolic effects. Several experimental and human studies have indicated that dopamine and norepinephrine may have different effects on the kidney, the splanchnic region or the pituitary axis, but the implications of these findings have not been assessed. Hence, both agents are widely used, and several consensus or expert recommendations still recommend the use of both agents 1,2. An observational study has reported that dopamine and epinephrine may be associated with a higher mortality rate than norepinephrine 3. In addition, The results of the SOAP study indicated that dopamine may be associated with higher mortality rates than norepinephrine, but various uncontrolled factors may have influenced these results. Therefore, we will address this issue in a prospective, randomized, double blind study. We hypothesize that both agents have similar effects on survival.