To evaluate the safety and efficacy of targeted renal sympathetic denervation using SyMapCath I™ in patients with pharmacotherapy and uncontrolled hypertension for at least 6 months, then after standardized antihypertensive drug therapy (at least two drugs) for at least 28 days, office systolic blood pressure (BP) is still ≥ 150mmHg, ≤180mmHg.