Using the nQuery statistical program, with the assumption that the proportion of discordant examinations is 0.15(or the conditional probability of positive finding in standard CTE is 0.90 if given a positive finding on the ASIR or MBIR CTE), the sample size needed to detect no more than 0.1 difference in sensitivity of the two procedures for patients with disease is 118, with a 80% power and a type I error of 0.025, one sided. Assuming that 80% of target population will have disease, approximately 148 subjects will need to be recruited. We have factored in a 10% drop out rate ( patients who leave the study for any reason) bringing the total number of patients to be recruited to 163.