Using the XTRAC® Ultra machine, in a pilot study of 9 patients receiving excimer laser therapy twice weekly for 12 weeks, 77% of patients achieved a Psoriasis Area Severity Index (PASI) 75 response ( ). In another study of 124 patients with stable plaque psoriasis (n = 124) covering less than 10% body surface area (BSA) were enrolled and 80 completed the study ( ). Seventy-two percent of patients achieved at least 75% clearing in an average of 6.2 treatments. Thirty-five percent achieved 90% clearing in an average of 7.5 treatments. In another study of 40 patients treated with the excimer laser under a protocol determined by MED of the involved skin, patients cleared in approximately half the number of treatments compared to patients treated under a protocol where dosage was determined by MED of non-involved skin ( ). However, aggressive laser therapy can also irritate the skin, and Clobex® spray can be an ideal partner to enhance the efficacy and prevent irritation of the skin from aggressive, supra-erythemogenic UVB irradiation. Moreover, beyond prevention of skin irritation, there are additional merits of combining Clobex® spray with excimer laser. These are the following: