Subjects: Incident ESRD patients. Patients with Stage IV and V (GFR <30 ml/min using MDRD mod equation) will be recruited from the renal clinics and private practices. Sites include both the Moses and Weiler campuses of the Montefiore Medical Center in Bronx, NY. Type of vascular access to be inserted will be determined on clinical grounds by the patient's nephrologist and access surgeon, these include hemocatheter, arteriovenous graft, and arteriovenous fistula.