After signing the informed consent, patients will be randomized in 1:1 manner into the treated or the control-cross group. After the randomization, patients will be invited for baseline evaluation that included full review of their medical status and complete physical examination. Patients will be instructed to refrain from any changes in their chronic medications or life style (e.g. exercise regimen) and to avoid new medications unless clinically indicated and approved by the study investigators. Quality of life (QOL) assessments (Seattle Angina Questionnaire [SAQ] translated to Hebrew) will be completed at baseline and every 2 month in the control period or following the treatment period.