Recently, another member anti-tumor class of taxane, Docetaxel (Taxotere) has been shown to be active in advanced head and neck cancer. In a randomized phase III trial of intensification of induction chemotherapy followed by radiation, the addition of docetaxel to the induction regimen of cisplatin and 5-fluoruracil when compared to cisplatin and 5-fluoruracil alone resulted in a 3-month improvement in overall survival (Vermorken et al, 2004). Thus both members of the taxane family, paclitaxel and docetaxel, have proven anti-tumor activity in head and neck cancer.