A published report of standard wheal and flare responses to histamine demonstrates that the sum of the longest (A) and orthogonal (B) (determined by the midpoint of A, labeled X) [Σ =A+B] diameter of the wheal and flare response to histamine was 7.0 cm ± 1.25 cm. (mean ± S.D.) Assuming that McCune-Albright patients will display a mean wheal and flare response 50% greater in diameter compared to controls, and using an alpha level of 0.05; testing of 10 patients will provide an 84% power to detect differences between patients and controls.