Different standard invasive approaches as percutaneous coronary angioplasty (PCI) and coronary artery bypass grafting (CABG) have been shown to increase myocardial perfusion when serial studies were compared before and after the intervention. Furthermore, non invasive anti-anginal medications as calcium channel blockers, beta blocker and nitrates as well as statins have been shown to similarly produce improvement in myocardial perfusion images as are combinations of these treatments, as required by modern evidence-based guidelines. It is presumed that these non-invasive approaches either decrease myocardial oxygen demand (e.g. Beta blocker) or increase coronary dilation (e.g. Nitrates) as the therapeutic means by which they contribute to ischemia reduction.