This study has been active since 1992 and all blood samples have informed consent for PrCa predisposition gene studies. Outside tumour blocks and pathological samples have informed consent for molecular studies. Many of The Royal Marsden NHS Foundation Trust PrCa tumour samples also have consent under a clause in the operation consent form in use at that time that 'material removed may be used for research purposes'. Some tissue was collected from local hospitals under the auspices of the previous protocol and the consent form did not explicitly state separate consent for the use of tissue at that time, although it was part of the approved protocol. Many patients are now deceased. It is therefore proposed that tissue and medical record data collected retrospectively will be analysed anonymously with no results fed back to patients as this would not impact upon their care. An exception is results from the studies on blood where findings in PrCa predisposition genes could have implications for relatives.