The included patients will be randomly assigned in one of two groups. A culture in Novy-Nicole-McNeal (NNN) medium will be taken for strain identification and a blood sample withdrawn from the antecubital vein for hepatic enzymes, creatinine, and pancreatic amylase determination. During this visit, a complete medical evaluation will be performed, the ulcer will be measured and a picture will be taken. Before taking the picture, a graduated rule will be placed next to the ulcer along with a sticker marked with the identification code of the participant, and the date of the visit. The first NOP (active or placebo) will be applied covering the lesion and the first shot of meglumine antimoniate (active or placebo) administered. The patients will receive information on how not to damage the patches and how to identify and report adverse events. To help the patients to do so, they will receive a diary to register them. The two groups randomly composed will be divided as follows: