In aggregate, this study will investigate the effects of weight loss on (1) Rho kinase activity obtained from peripheral leukocyte (2). Aortic stiffness, central aortic pressure and hemodynamic by a noninvasive technique (3) Brain function specifically reflecting by circulating BDNF levels (4). Aortic elastic properties and left ventricular function by using MRI examinations, in non-diabetic individuals of metabolic syndrome. Findings from this integrated proposal will provide valuable information as mild to moderate weight loss (5% of initial body weight) in cellular, cardiac and central nervous system in additional to well-known effects on lipids, inflammatory cytokines and insulin resistance in non-diabetic subjects with metabolic syndrome.