We have not received in the past five years reimbursements, fees, funding or salary from any organization that may in any way gain or lose from the publication of this manuscript, either now or in the future. We don't hold any stocks or shares in an organization that may in any way gain or lose financially from the publication of the manuscript, either now or in the future. We don't hold or are currently applying for any patents relating to the content of the manuscript. We have not received reimbursements, fees, funding or salary from an organization that holds or has applied for patents relating to the content of the manuscript.