New research acknowledges that long-term treatment with ACEI or ARB does not reliably suppress RAAS over the long term, a well-documented phenomenon known as aldosterone escape. Aldosterone is a potentially important component of RAAS, which has not been well investigated in the context of AF prevention in patients without heart failure. After a period of initial suppression, aldosterone concentrations increase to normal or above normal levels. Spironolactone can prevent aldosterone escape and prohibit fibrosis more effectively than ACEI and ARB. It was shown to reduce mortality in patients with heart failure, but data on the effect on the incidence of atrial fibrillation are still limited.