ii) Baseline Visit (Day 0): Determination of diagnostic eligibility criteria and the results of blood and urine analysis studies will be reviewed. Evaluation will include weight, heart rate, blood pressure, and respiratory rate, physical examination, rating scales for tics, obsessive-compulsive problems, ADHD, depression, and anxiety. As part of the baseline visit, the PI and Study Coordinator will meet with the parent to explain the procedures for dose titration, review in detail the outcome measures, and review approaches to administering medication (e.g., providing the pill with water or other beverage, observing the child swallow the medication without biting or chewing). Following confirmation of study eligibility, Dr Singer will forward a request for medication to the Johns Hopkins Research Pharmacy.