After cleaning the skin with alcohol swabs, an acupuncture needle (30 Gauge, 0.30X30 millimeter, Mac Spring Handle Needle, Korea) will be swiftly inserted approximately 5-10 mm deep bilaterally at both LI-4 and LI-11 acupoints of each arm and at ST-36 acupoint of each leg. Electroacupuncture (EA) will be delivered by a stimulator (Digital Electronic Acupunctoscope 4-C, Model AWQ-104L™ Hong Kong, Dist by Lhasa Medical, Weymouth, MA) via electrodes from the stimulator at 10 Hz frequency with the electrical current of continuous wave. This setting showed significant anti-hyperalgesic effects in a rat inflammation model (22, 23) and also inhibited the up-regulation of IL-1β and its messenger Ribonucleic acid (mRNA) compared to the sham control in a rat model of bone cancer pain (24). EA is a particularly therapeutic method in which a small electrical charge is applied to acupuncture needles inserted at the acupoints. EA has the advantage of combining the stimulation of both needles and electricity compared to manual acupuncture alone, and may potentiate the effect of the acupuncture treatment along the meridians. One end of electrode will be attached to the acupuncture needle handle at LI-4 acupoint, and another end will be attached to the acupuncture needle handle at LI-11acupoint bilaterally. For EA on ST-36, one end of electrode will be attached at the right side ST-36 acupoint and another end will be attached at the left side ST-36 acupoint. A symmetrical biphasic wave will be delivered to the electrodes so that the electrode will be alternately positive and negative and the bilateral LI-4, LI-11, and ST-36 acupoints will be stimulated alternately. Mild muscle twitching will be observed.