We will evaluate the associations of haplotypes 1-6 with response/non-response to adrenergic agonists using a case-control study. Using the data in Table 1 and assuming that the cases make up 25% of the study subjects, and using the function haplo.power.cc. We require a sample size of 1243 patients to be able to detect at least a 40% increase in risk of non-responsive to adrenergic agonists in patients with haplotypes containing Arg16Arg compared to haplotypes without Arg16Arg with 80% power at 0.05 level of significance. Under similar assumptions, we require a total sample size of 865 to be able to detect a 50% increase in risk of treatment failure in patients with haplotypes containing Arg16Arg compared to patients without. The number of subjects represents the total required to achieve sufficient power given a 75:25 treatment success-failure ratio.