The optical and operating trocars are inserted through the access device and the procedure is carried out as a conventional laparoscopic procedure. Many short case series and reports have been published describing the feasibility of SILS in performing complex surgical procedures for both benign and malignant disease[13,14,15]. Specialised, complex colorectal procedures such as proctocolectomy with ileal pouch-anal anastomosis (IPAA), ileocolic resection for terminal ileal Crohn's mass and colonic resection for cancer have been successfully performed using single incision laparoscopic surgery[16,17,18,19]. To date, several short series of SILS right hemicolectomy have been published in the literature[20,21].Thus, rather than a new or novel technique, SILS is a derivation of laparoscopic surgery, performed through a single incision. There is no evidence in the literature that SILS colectomy confers any disadvantages over conventional laparoscopic surgery and to dtae, there are no reports of SILS putting patients at increased risk of complication. Postulated benefits of SILS colectomy over conventional laparoscopic colectomy include reduced number of incisions, improved cosmesis, less pain, faster return to normal activities/work and shorter hospital stay. Heretofore, there has been no randomised controlled clinical trial comparing SILS and standard laparoscopic right hemicolectomy for cancer. Having previously demonstrated the benefits of laparoscopic resection over open resection in the treatment of colon cancer we feel the time is ripe to further extrapolate these data by comparing laparoscopic right hemicolectomy with a proposed new treatment modality, single incision laparoscopic right hemicolectomy, in the format of a multicentre, international randomised controlled clinical trial.