The treatment phase of the trial terminates at 8 months. At T= 12 months, diagnostic high resolution endoscopy is performed with targeted biopsies of any abnormal areas as well as 4 quadrant biopsies at 2 cm intervals of the area containing or previously containing the BE. The biopsies are in order to identify 'buried' Barrett's glands under the new squamous epithelium. The clinical endpoint is at 1 year when recurrent or persistent HGD or cancer will be assessed. Any residual BE (not containing HGD or cancer) will be assessed and recorded.