This is a prospective, single-center, randomized, double-blind study. All participants will be recruited from a research center in Porto Alegre, Brazil, and provided written informed consent. This study will be approved by the local Ethics Committee of Associação Hospitalar Moinhos de Vento and all Good Clinical Practices, Declaration of Helsinki protocols and national regulations were followed. The main inclusion criteria are: female subjects aged between 18 to 60 years; presence of moderate to severe forehead wrinkles on both sides at maximum contraction of frontalis muscle according to Wrinkle Severity Scores (WSS) (Hexsel et al., 2012); positive sweating by the Minor's Test (Minor, 1927) and scores from III to V on the Sweat Intensity Visual Scale (Hexsel et al., 2010).