(1) diameter <4mm or treatable length <25mm; (2) Multiple renal arteries and the main renal artery supplies a fraction of the blood flow less than 75% (3) Renal artery stenosis >50% or any renal artery aneurysms on either side (4) History of renal artery PTA, including balloon angioplasty and stenting 2. eGFR <45mL/min/1.73m2 (MDRD formula) 3. Hospitalized within one year due to hypertensive crisis 4. Average 24-hour systolic blood pressure (SBP) <135mmHg 5. Pulse pressure＞80mmHg 6. During running in period, using standardized antihypertensive drugs and other antihypertensive drugs 7. Participated other clinical trials including both drug and medical device studies within 3 months enrollment 8. Female with pregnant or lactating, or having plans for pregnancy within 1 year 9. Patient with sleep apnea who needs chronic oxygen-breathing or mechanical ventilation support (for example, tracheostomy) 10. Patients previously or currently suffering from following diseases: