Secondary analysis of data from "The effects of Biobran/Lentin Plus in the adjuvant therapy of hepatocellular carcinoma and chronic hepatitis B" study. The study was a randomized controlled design that was conducted from 6/2006 to 7/2008 at the 108 Military Central Hospital, Hanoi, Vietnam with Dr. Mai Hong Bang as the Principal Investigator. MGN-3/Biobran was approved by Vietnam Ministry of Health with import VISA No.12577/2005/CBCL-YT. Therefore, The 108 Military Central Hospital approved the study for treatment of patients with HCC and hepatitis B too.