The primary outcome variable will be the genetic patterns (SNPs and haplotypes) in each population. We wish to evaluate SNP patterns and albuterol responsiveness using a case control study. Between-group comparisons will be made by analysis of covariance. The associations between baseline PEFR and the percent improvement following albuterol will be stratified for SNP pattern and will be assessed by analysis of covariance. Single polymorphisms may be insufficient and it has been suggested that haplotypes containing multiple polymorphisms may be more informative. Drysdale and coworkers identified 13 polymorphisms and organized them into 12 haplotype groups with varying frequencies between ethnic groups. The four most common were haplotypes 1, 2, 4 and 6. Haplotype 2, which contains Gly16 homozygotes, was associated with the greatest FEV1, reversibility while haplotype 4, which contains Arg16 homozygotes, was the least. Five haplotype pairs were common in asthmatics. Homozygotes, haplotypes 2/2 had the greatest impact on FEV1 and protein expression while haplotype pair 4/4 showed the least effect in both categories. Since no isolated SNP may have any predictive utility, that is why we are measuring the haplotypes. The haplotype combination 4/4 produces the smallest impact and may be operational in the non-responders. The haplotype pair 4/6 produces the largest improvement with albuterol, and, therefore, may be operational in the responsive group.