Prof. Stavros Konstandinides, University Hospital Göttingen, is a pulmonary embolism expert who will serve as Data Safety Monitoring Officer (DSMO). The Sponsor is responsible for reporting any adverse events to the DSMO as described above. In addition, safety endpoints will be reviewed by the DSMO after each 10 enrolled patients. The DSMO can suggest to terminate the study prematurely based on concerns about patient safety.