Anticipated Findings and Conclusions During the hypertonic saline infusion trial water balance will be artificially manipulated (hypertonic hypervolemia). The increase in plasma osmolality will stimulate vasopressin secretion. It is anticipated that AVP stimulation will elevate insulin to a greater degree than glucose resulting in higher insulin resistance. It is also expected that great urine osmolality as a response to elevated vasopressin levels and lower urinary output.