A strong argument against waiting for the coagulopathy to develop before treating is that the consequences of the coagulopathy are so grave that they should be avoided. The coagulopathy of hemorrhagic shock is a major component of the 'lethal triad' seen in hemorrhaging patients (in conjunction with acidosis and hypothermia). The lethal triad has a very high mortality rate (over 70%) with limited ability of physicians to treat it. Evidence supporting this argument has primarily come from the conflicts in Central Asia. Several retrospective studies have been published by the US Army Institute of Surgical Research that have not only challenged this practice but have resulted in changes in how the US armed forces manage trauma patients. The US military now uses plasma in a 1:1 ratio in their traumatized soldiers (i.e. 1 unit of plasma given for every unit of packed RBC).