CRP is a sensitive major acute phase protein, synthesized by hepatocytes under transcriptional control by IL-6. In the presence of human serum, CRP induces the expression of MCP-1, VCAM-1, ICAM-1, and E-selectin. (5). The interaction of CRP with monocytes in vitro results in the release of IL-1 β, IL-6, TNF-α, and tissue factor.(6)