Benefits to the Community: There is a disproportionately high incidence of HCC in developing countries, and over 50% of HCC cases occur in Asia. Hepatitis B is closely linked to liver cancer, which is almost always fatal. It is estimated that nearly 80% of all liver cancer worldwide is caused by hepatitis B infection. Therefore, there is a need for new treatments with minimal to no side effects to combat these diseases. This study will determine the potential of MGN-3/Biobran combined with conventional therapy to improve the outcome of these diseases.