The hypercoagulable state represents one of the physiological changes occurring during pregnancy. The hereditary thrombophilia (HT), a genetic predisposition to inappropriately form clots, significantly increases adverse outcomes including recurrent miscarriages, intrauterine fetal death and growth retardation, preeclampsia and placental abruption. It is well known that inflammation promotes coagulation and IL−6 high levels in plasma of HT affecting pregnant women with severe preeclampsia have been found. Moreover, elevated intra−amniotic IL−6 and IL−8 levels have been correlated to preterm birth.