A recent study from the investigators' group, looking at the rest time required for recovery and resensitization of the OTR following desensitization, showed that there were no improvements in oxytocin-induced myometrial contractility after either a 30, 60 or 90 minute rest period. The reason for why resensitization does not occur remains unknown, but a possible explanation is that the OTRs undergo structural and functional changes during desensitization that prohibit their recovery.