The initial/loading dose of cetuximab is 400 mg/m2 IV administered over 120 minutes. Patients must be continuously observed during the infusion for signs of anaphylaxis and standard resuscitative meds should be in close proximity. Vital signs should be taken prior to, during, post and 1-hour post infusion for the initial dose. For subsequent infusions, vital signs are recommended to be taken to and 1-hour post infusion.