- Sample size analysis: Sample size is estimated to demonstrate statistically significant difference in cardiovascular event rate up to 5 years after inclusion between patients with moderate or extensive intraplaque neovascularization (vulnerable lesions/patients) and no intraplaque neovascularization (stable lesion), assuming a 2-sided level of statistical significance of .05, 80% power, and an event rate of 30% in the group with intraplaque neovascularization compared to 15% in the group without intraplaque neovascularization.This results in a requirement of total 240 individuals in this study project.