We recently reported in Colombia, the existence of a strong association between the presence of cardiovascular risk factors and altered fasting plasma glucose, this association being greater with the presence of abnormal glucose blood levels after the glucose overload test. This association has been explained since the hyperglycemia per-se may be implicated in the development of atherosclerosis due to metabolic and structural changes at the endothelial level. At long term it may result in irreversible alterations; a "non-returning" point leading to cardiovascular complications typical of diabetes. According to these observations, our group has recently shown that patients with altered glycemia in fasting, regardless of other classic factors of cardiovascular risk, present a greater risk of coronary disease, supporting the hypothesis that the hyperglycemia leads to structural changes in the endothelial wall.