Because the study medication, mecamylamine, may cause a drop in blood pressure, we plan to monitor each subject’s blood pressure (sitting and standing) on a weekly basis. If a subject develops a systolic blood pressure < 100mm Hg, we will plan to monitor blood pressure twice weekly. If a subject develops a systolic blood <90mm Hg, we will plan to discontinue study medication. Lastly, if a subject experiences a systolic blood pressure drop >10mm Hg, we will plan to monitor twice weekly or until the problems resolves.