In a study of 1254 subjects treated with clobetasol propionate spray 0.05% as monotherapy twice daily for four weeks, 35.7% of patients achieved clearance and 37.3% of patients were almost clear using a 6-point target plaque severity scale. Additionally, at week 4, 80% of subjects achieved target plaque severity (TPS) success, p<0.001. This was specifically defined as a score of clear, almost clear using the TPS scale or an improvement in severity of 2 grades. Topical steroids have the potential for adrenal suppression. However, when topical steroids are used for one month or less at a time, this transient adrenal suppression that may result is not a clinical problem.Furthermore, when using Clobex® spray, patients are required to have a steroid-free interval after 4 weeks of therapy. The effect of Clobex® spray can be maintained with a safe, non-steroidal topical medication, such as Vectical. This newer Vitamin D topical agent can be used up to 210 g weekly, as compared to topical calcipotriol (Dovonex®) which is limited to 100 g weekly, due to the better safety profile of Vectical. Thus, Vectical can be used for patients with generalized plaque psoriasis covering up to 35% body surface area. In addition, a comparative study in 250 patients demonstrated that Vectical caused significantly less skin irritation as compared to calcipotriol ( ). Thus, with the imminent approval of Vectical, we are entering a new era where a Vitamin D analogue can be used to treat patients with generalized psoriasis. With these three "storms" gathering force, we propose the following study.