Firstly, randomising up to 100 suitable patients over a 1 year period, identified at the upper gastrointestinal cancer specialist multidisciplinary team meeting in 6 expert English centres. Patients will have either high grade dysplasia (HGD) or early cancer in Barrett's oesophagus (BE) and will be randomised to two curative endoscopic non-surgical therapies (endoscopic resection [ER] and argon plasma photocoagulation [APC] versus ER and radiofrequency ablation [RFA]). All techniques are used in current clinical practice, but have never been directly compared.