Indeed, a convincing argument can be made that rather than monitoring HIV-exposed breastfeeding children for HIV infection, it may be more appropriate to simply monitor for treatment eligibility, followed by a definitive antibody test at 15-18 months or a few months after breastfeeding has stopped. Those children who meet criteria for treatment could be commenced on ART; those who do not would continue to undergo periodic screening until they were weaned and old enough to have a final (definitive) antibody test. For HIV-exposed infants without access to HIV PCR testing - the vast majority in Africa - development of such an algorithm would have the obvious benefit of providing reliable evaluation for treatment eligibility in the first 18 months of life. Even in settings where HIV PCR testing is available - but may be limited - the introduction of such algorithms could reduce the volume of HIV PCR tests required at a programmatic level, and thus lead to substantial cost-savings.