Nail problems pose substantial problems for patients with breast cancer undergoing chemotherapy in terms of quality of life. It is a difficult challenge for health care professionals to manage and provide advice, mainly due to the lack of evidence on effective solutions. There is a need to look at the options that may have potential benefit to patients, including toxic-free formulation of dark nail polish and OnicoLife drops ® which appear to be useful, however, there is no research based evidence to support their use.