Valproic acid (VPA), as a HDAC inhibitor, can specifically target at class I a, I b, and II a HDACs (8). VPA also down regulates expression of proteins essential for chromatin maintenance: Structural Maintenance of chromatin (SMC), DNA methyl transferase-1 (DNMT1), and heterochromatin protein-1 (HP1) (9). VPA had been shown to induce histone 3 methylation which would increase transcriptional activity (8). VPA had been shown some anticancer effect, major through its HDAC inhibitor, in single agent or combined with other anticancer medication including myeloid and lymphoid malignancies, breast cancer, prostate cancer, and NPC (10-13) Long-term VPA treatment may cause central nervous system (CNS) dysfunction, liver toxicity, and coagulopathy including thrombocytopenia and platelet dysfunction (7).