Albuminuria. Albumin and creatinine will be measured during the 2nd run-in/assessment /Baseline session by urine sample (see Core B). Serum creatinine will also be measured. Patients will be excluded if there is evidence of renal disease (i.e., urine dipstick protein 4+; serum creatinine ≥ 1.4 mg/dL in women or 1.5 mg/dL in men; or currently receiving dialysis). In those patients who meet criteria for entry into the study, the incidence and progression of microalbuminuria or greater level of excretion will be assessed using an albumin/creatinine ratio at both 6 month and 12 month follow-up. Serum creatinine will also be measured at these times.