Following parental consent and child assent, children will wear a wrist actigraph to monitor sleep activity every day (during they are hospitalization various four times)(there are five days in each period )and be asked to complete the Taiwanese versions of the Memorial System Assessment Scale (MSAS, 10-18), Fatigue Scale (7-12, 13-18), and the QOLCC at day 1. Then the measurements will be repeated every other day for the following consecutive five days during each cycle of CXT for at least four cycles of inpatient CTX. Parents will be asked to complete the SF-36 for their quality of life and Parent Perception Uncertainty in Illness Scale at day 0 and every other day following consecutive five days during one cycle of CXT for at least four cycles of inpatient CTX.