Codeine is a very effective agent in causing release of histamine from mast cells and is commonly used in addition to histamine. We plan to use codeine as well as histamine skin testing to evaluate histamine response. Comparison of codeine responses between the MAS patients and unaffected controls will be made. Age and sex do not exert major effects on histamine responsiveness. Only infants and adults over the age of 50 have been noted to have decreased responsiveness in comparison to other age groups. Menstrual cycles in females have been noted to cause slight variation with increased dermal reactivity around ovulation and lower reactivity during the menses. Because most girls with McCune-Albright have irregular menses it will be difficult to time skin testing with the menstrual cycle. Therefore, we will record the date of last menstrual period for each female patient and control.