Extensive research has been ongoing to try to find various ways in which the excess deposition of β Amyloid, the removal of excess β Amyloid, the initiation sequence that it is involved in with phosphorylated TAU and other selective processes can be altered in an effort to mitigate the devastating end term results. To date, there have been several trials, including a vaccine trial performed in Europe and in the United States, which seem to show that clearance of the β Amyloid is possible. However, there was not significant improvement in neurocognitive function (NCF), which led to the discontinuation of these trials.