Other than the AVP effects on blood pressure and water homeostasis, the hormone is implicated in a variety of other functions including pain, bone and lipid metabolism, hypertension, social behavior, aging, cognitive function, cellular proliferation, inflammation, infections, homeostasis, hypothalamic-pituitary-adrenal axis, and diabetes. All these effects could provide useful insight into many diseases. Therefore, the focus of this application is on the effects of AVP on glucose regulation in healthy humans.