text:
"What a VOICE!'...Random House, Andrea Robinson
"A book full of passion, soul and powerful writings..." Appalachian Voices Magazine
"Your writing is eloquent. It transports me back to my mountain. I cherish my copy."...Earl Hamner, noted author and creator of The Waltons series
"With deep Appalachian roots, Diane appreciates your book.'...Voice message Diane Sawyer's office, ABC News
"Some books are the real deal--this is one of them."...Gwen Mansini, Virginia
"Words matter. Barbara has expressed in well-written, beautifully descriptive words who, what, when and where she wishes to spend her time within God's creation, using the oldest art known to man--storytelling. "A Time For Every Purpose" is her crowning glory. I recommend it highly."...Amy Ammons Garza, Catch the Spirit of Appalachia


text: Darren Reed writes: >> I think he's asking if there is a proper directory structure to hold the >> install files on the CD in addition to make the CD bootable. >Right. I don't want to make /NetBSD-1.3 if sysinstall requires >/pub/NetBSD-1.3 on the CD. AFAIK, sysinst gets this wrong too :). Those of us working on sysinst never got good feedback from anyone acutally wanting to produce CDs. I think the 1.3 release sysinst looks in /Release/NetBSD/NetBSD-1.3. Maybe the anticipation was that someone producing a CD distribution would make sysinst use something sensible for their production. I'd welcome feedback on what we should do here. It'd be nice if we could pick a `standard' that would work for all ports, even if multiboot CDs is not currently an option. If it needs changing, perhaps we can get a change into the next patch release. If that fails you can always install from the CD (which is otherwise a coaster), using the the "unmounted fs" option. Note that the `directory' is the directory, relative to the root of the mounted-from local filesystem (e.g., the CD) in which to find a release(7) hierarchy.

subset: commoncrawl


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Real Madrid took their customary team photo before the UEFA Super Cup match with Sevilla. Metro UK dutifully noted Ronaldo stood on his tip toes to look taller than his Real Madrid teammates. A quick run through the photo archives indicates this is his standard operating procedure.
Here is Ronaldo from the Champions League semi-final match with Bayern Munich on April 29th.
Here he is before Real Madrid played Schalke in the second leg of the Champions League Round of 16 on March 18th. French defender Rafael Varane, standing to his right, is 6'3″.
He wasn't going to let the unfashionable orange kits daunt him in the first leg either.
In case you figured this was strictly a Real Madrid thing, he did it at the World Cup too. Here he is before the Germany match…
We'd call him vain. But if our images were worth nine figures to advertisers across the globe, we'd do whatever it takes.
[Photos via Getty]
RELATED: Cristiano Ronaldo and Gareth Bale Hooked Up For a Nice Goal at the UEFA Super Cup
RELATED: Cristiano Ronaldo Has Some Very Weird Japanese Endorsements
RELATED: Cristiano Ronaldo Unveiled His Underwear To The Entire Western World


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Later, 'gator: Deputies pull small intruder from pool
WINTER HAVEN (FOX 13) - What better way to celebrate Water Safety Month than by making sure your pool is alligator-free? That's what some Polk County deputies found themselves doing Monday.
The deputies were called to the home in the Cedar Cove neighborhood of Winter Haven after the little alligator was spotted taking a dip in a pool. They were able to pull the trespasser out and "make the pool safe again," the sheriff's office joked in a Facebook post.
Wildlife experts have warned that alligators – already aggressive as mating season arrives – may be even more mobile because of low water levels around the state.
Florida's alligator population is about 1.3 million, and alligators live in all 67 counties.
More stories about alligators:
- WATCH: Horse clashes with alligator in Florida state park
- WATCH: Massive gator saunters across path at Polk County reserve
- Meet 'Pearl,' the rare albino alligator at Gatorland
- Gargantuan alligator is big draw after viral video
- VIDEO: Burmese python fights alligator in Big Cypress swamp
- Alligator swims peacefully with manatees at Blue Spring
- Rambo the alligator allowed to stay with owner in Lakeland home
- WATCH: Gator jumps into vacationer's boat during Facebook Live


text:
JCPenney recently sent home (now former) employee Sylva Stoel for wearing shorts deemed "too revealing" for work, which is hilarious because the shorts are from JCPenney. What makes it even funnier is that Stoel worked in the store's Career section. And with one tweet, featuring the supposed scandal of a clothing item, Stoel set the social media world aflame.
Boss sent me home for wearing "too revealing" shorts that I bought from the store I work at in the career section. pic.twitter.com/vrAnN4beC2— Sylva (@queenfeminist) July 24, 2015
Now everyone wants to know why this isn't like some sort of fashion world entrapment, so a JCPenney spokesperson recently told People:
JCPenney's dress code policy for store associates prohibits the wearing of shorts of any length. This policy applies to both male and female associates. We have reached out to the associate who blogged about this policy, but she has not returned our telephone calls thus far.
Stoel, however, says she was never informed of this, and the whole thing since has become a much larger conversation.
"Rules are rules" but when the rule is unfair we must question WHY it's a rule, WHO made the rule, and then BREAK THAT RULE.— Sylva (@queenfeminist) July 28, 2015
Dress codes benefit patriarchy bc they shame women for "dressing provocatively" and absolve men from all blame. Break the dress code.— Sylva (@queenfeminist) July 28, 2015


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On Thursday, March 16, at the New School in New York City, the National Book Critics Circle (NBCC) announced the recipients of its book awards for publishing year 2016. As with last November's National Book Awards, a sense of political urgency hung over the proceedings. Michelle Dean, awarded the Nona Balakian Citation for Excellence in Reviewing, set the tone by arguing that "what a writer is supposed to do is pay attention," particularly to worldwide suffering and the role of power in society. Distinguished Canadian author/activist Margaret Atwood, who received the Ivan Sandrof Lifetime Achievement Award, cemented these sentiments by proclaiming "Never has democracy felt so challenged."
The impulse to social engagement extended to the books themselves. Expanded from an op-ed in the Washington Post, criticism winner Carol Anderson's White Rage: The Unspoken Truth of Our Racial Divide (Bloomsbury USA) portrays white America's repeated angry resistance whenever African Americans advance. Nonfiction winner Matthew Desmond's Evicted: Poverty and Profit in the American City (Crown), also an LJ Best Book and winner of the Andrew Carnegie Medal for Excellence in Nonfiction, highlights homelessness in America by chronicling landlords and their struggling tenants in Milwaukee. As Desmond explained in his acceptance speech, "The majority of poor people in this country spend nearly half of what they have on housing costs, and the evictions are coursing through our cities, acting like a cause and not just a consequence of poverty." Thanking the people of Milwaukee, he added that the award was "an affirmation of their lives."
Louise Erdrich carried on her highly regarded exploration of Native American life with fiction winner LaRose (Harper), the story of two families dealing with a child's accidental killing, and also carried on the spirit of the evening in her acceptance speech. "I am happy to be in a room full of searchers. Let us all be fiery and dangerous about truth," she proclaimed. Erdrich's first novel, Love Medicine, also won an NBCC award.
Erdrich went on to praise the NBCC Emerging Critics Fellowships, which aims to identify and nurture the best young critics and whose first recipients were announced at the ceremony. Of young people, she said, "We need your spirit," an observation that might extend to Yaa Gyasi, whose Homegoing (Knopf) received the John Leonard Prize, awarded by membership vote to an outstanding first book in any genre. Gyasi's far-reaching novel extends from 18th-century Ghana to the African American experience of slavery.
Ruth Franklin's Shirley Jackson: A Rather Haunted Life (Liveright: Norton), which won the biography honors, expands our understanding of an iconic author by clarifying her frustrations as a woman and a mother trying to make her mark as a writer in mid-20th century America. "I'm happy that Shirley Jackson is getting this recognition," observed Franklin from the stage.
Autobiography winner Hope Jahren's Lab Girl (Knopf) clarifies the joys of geobiology and the challenges of being a woman scientist. Currently working in Norway, Jahren was blocked from attending by the snowstorm that hit the Northeast 48 hours before the ceremony, which she said in letter read by her editor, Knopf vice president and editorial director Robin Desser, "hurt worse" than missing her chance for front-row seats at a Thompson Twins concert in her youth, also owing to snow.
Finally, poetry winner Ishion Hutchinson's House of Lords and Commons (Farrar) builds from sometimes fraught memories of a Jamaican childhood to take on a larger world of greed and violence in condensed, beautifully complex language. There are moments of desolate tenderness, too, as when the poet imagines spotting his father in crowd. Like all good writing, Hutchison's embraces the personal as well as the political, which he emphasized by dedicating his award to the grandmother who encouraged him to write.
The same can be said of Erdrich's or Gyasi's address of culturally weighty issues through family or Desmond's empathetic treatment of all parties involved in eviction. If, as Atwood said in a speech often directly addressing the critics, "there are places on earth where to be caught reading you–or even me–would incur a severe penalty," this year's NBCC winners are to be valued not just for their fighting spirit but for the bracing roundness and individuality of their vision.


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Friday, August 28, 2009
Fall Thanks
Sorry, I don't have coloring photos for this one. I accidentally deleted all my leaf photos, but I'll be sure to do pictures the next time I use this set. I did used Copic markers to color and sponged the background. The vertical panel is a piece of my new All About Autumn digital paper.
Melanie has an A Year of Leaves project on her blog today and her guest designers are all posting projects, so for some great Leaf inspiration be sure to visit Melanie, Geri, Laurie and Sharon.
I'll be back tomorrow with a project using my new stamp set, Autumn Beauty and I'll have lots of details photos to go along with it.
Thanks for stopping by. Have a great day!
12 comments:
- Anesha said...
Beautiful colouring. Great layout as well. Anesha
- August 28, 2009 at 8:24 AM
- Patti J. said...
Beautiful card, Theresa! I love your fall colors, and as always, your coloring and execution is sheer perfection! Thanks for sharing!
- August 28, 2009 at 8:32 AM
- http://www.treesawardincrafts.blogspot.com/ said...
Theresa, I have just found you and I am so glad I have, I love this card and your previous tutorials, they are just what I need to improve my skills. Thank you so much.
- August 28, 2009 at 10:02 AM
- Payne Holler Cards said...
really enjoyed the release party last night - your cards were absolutely tremendous!!! gotta wait though to get this set :(, its either buy Autumn or Christmas...and I know I will want everything you do for Christmas also!!! LOL
- August 28, 2009 at 1:01 PM
- August 28, 2009 at 7:48 PM
- Dawn Frost said...
I love the deep rich colours! Gorgeous card.
- August 29, 2009 at 7:30 AM
- Heather "Hev" said...
Popping by to say hi :)
Missing my time to blog hop - but hope to pop by and comment properly soon :)
Finally managed to make a card or two :)
Hope you are well
- August 29, 2009 at 10:33 PM
- Carol said...
Another beautiful card! I love fall colors. And I love your new digi paper-sooo pretty!
- August 30, 2009 at 6:50 AM
- froebelsternchen Susi said...
perfect and lovely!
- August 30, 2009 at 11:11 AM
- Melanie said...
this is so gorgeous, thanks for spreading the word! :)
- August 30, 2009 at 1:53 PM
- Whimcees said...
This is gorgeous! You are a most creative amd talented artist!
Thank you for sharing!
Barbara Diane
- September 1, 2009 at 8:28 AM
- melissac said...
Stunning!! thank you again and again for the wonderful directions and pictures on how to create beautiful cards and projects! blessings and hugs!
- September 1, 2009 at 4:26 PM


text:
Jamaican Sorrel Drink
If you like it, save it!
Save and organize all of the stuff you love in one place.Got it!
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Click the heart, it's called favoriting. Favorite the stuff you like.Got it!
Author Notes: This is a traditional Jamaican drink that is based from a hibiscus flower that is harvested in the winter. It is slightly spiced and spiked with Jamaican white rum. Traditionally served during the Christmas holiday season, however, Jamaicans drink it at any celebratory occasion all year round. —Briana Riddock
Serves 4
- 1 1/2 cups dried sorrel petals
- 1 cinnamon stick
- 1 piece dried orange peel
- 4 whole cloves
- 2 cups sugar
- 8 cups boiling water
- 1/4 cup Jamaican white rum
- 5 pimento seeds (allspice seeds)
- 1/4 cup freshly crushed ginger
- Bring water to a boil and remove from the heat. Add sorrel petals, cinnamon, orange peel, cloves, sugar, ginger, and pimento seeds. Allow ingredients to steep for 4 hours. (If you have more time allow mixture to steep over night.)
- Strain the drink with a fine mesh strainer and stir in the rum. Refrigerate the drink and serve chilled.


text:
These heels feature a pointed toe look, top buckle strap, gold stud accents, Heel measures about 4.5 inches from top to bottom.
You're reviewing: BLACK POINTED TOE TOP BUCKLE STRAP GOLD STUD ACCENT HIGH HEELS
You may also be interested in the following product(s)
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text:
Please note: For your convenience, this calculation has been rounded up slightly.
Important reminder: Every effort has been made to ensure the accuracy of this calculation. But before purchasing materials for any project, please check amounts with your suppliers or contractors.
Helpful Information
When choosing a window air conditioner, don't assume that buying the most powerful model is the best choice. An air conditioner that is too powerful for the room will not remove enough humidity, because it cools too quickly. And of course, a model that is too weak will fail to make a room comfortable. The cooling power of an air conditioner is calculated in British Thermal Units (BTUs). (One BTU is enough energy to heat one pound of water by 1 degree F.)
A few tips: If you need to install a unit that delivers 12,000 BTUs or more, have an electrician install a 240-volt receptacle. Smaller units can be plugged into a standard 120-volt receptacle, but make sure that by doing so you will not overload the circuit (see our Circuit Load estimator).
Other factors to consider: If the room is directly above a room with no air conditioning; if more than three people typically inhabit the room; or if the room's door will often be opened and closed, buy a model approximately 1,000 BTUs stronger than indicated by this calculator.


text:
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: Life in Pictures by cowardlylion
thanks to Gambit from TDA. <3
Rose Weasley has made a tragic mistake, and she lives with it every day. But when scary things start happening and the past replays itself, she goes on the run, battling time to find answers.
Genres: Horror/Dark, Romance, Angst Era: Next Generation Characters: Albus, Harry, Hermione, Hugo, James (II), Molly, Ron, Rose , Scorpius, Seamus Pairings: Rose/Scorpius
Advisory: Strong Language, Strong Violence, Scenes of a Mild Sexual Nature, Sensitive Topic/Issue/Theme
Published: 2010.12.02 Latest Chapter: 2010.12.20 Updated: 2010.12.20 Status: WIP (4191 words)
: I Swear, This Time I Mean It by cowardlylion
Banner by KaylaJ @ RC&R
So I'll sing a melody, and hope to god she's listening
sleeping softly while I sing, and I'll be your memory,
your lullaby for all the times, hoping that my voice can get it right.
- I Swear This Time I Mean It, by Mayday Parade.
Lyrics in Story Title and Summary belong to Mayday Parade
Genres: Drama, General, Romance Era: Post-Hogwarts Characters: Draco, Ginny, Harry, Hermione, OtherCanon , Ron Pairings: Draco/Hermione, Harry/Ginny, Ron/Hermione, Ron/Lavender
Advisory: Strong Language, Mild Violence, Scenes of a Sexual Nature, Sensitive Topic/Issue/Theme, Contains Spoilers
Published: 2010.01.25 Latest Chapter: 2010.02.25 Updated: 2010.02.25 Status: Abandoned (1119 words)
: I Remember... by cowardlylion
TY nantes @TDA
Genres: Horror/Dark, Romance Era: Next Generation Characters: Albus, Draco, Harry, Hermione, James (II), Ron, Rose , Scorpius Pairings: Rose/Scorpius, Draco/Pansy, Harry/Ginny, Ron/Hermione
Advisory: Strong Language, Mild Violence, Scenes of a Sexual Nature
Published: 2010.02.07 Latest Chapter: 2010.02.25 Updated: 2010.02.25 Status: WIP (2105 words)


text:
|18th week of 2009 patent applcation highlights part 39
|Patent application number
|POLYPEPTIDE REGULATING PHOSPHATE METABOLISM, CALCIUM METABOLISM, CALCIFICATION AND VITAMIN D METABOLISM AND DNAS ENCODING THE SAME - A DNA, which encodes the following polypeptide (a), (b), (c) or (d):
|RECEPTOR ANTAGONISTS FOR TREATMENT OF METASTATIC BONE CANCER - The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering an IGF-IR antagonist and/or a PDGFRα antagonist. The invention also provides antibodies that bind to human PDGFRα and neutralize activation of the receptor. The invention further provides a methods for neutralizing activation of PDGFRα, and a methods of treating a mammal with a neoplastic disease using the antibodie alone or in combination with other agents.
|Methods and compositions for pulmonary administration of a TNFa inhibitor - The invention describes methods of pulmonary delivery of a TNFα inhibitor to a subject having a disorder in which TNFα is detrimental, such that the disorder is treated. Also included is a method of achieving systemic circulation of a TNFα inhibitor in a subject comprising administering the TNFα inhibitor to the central lung region or the peripheral lung region of the subject via inhalation, such that systemic circulation of the TNFα inhibitor is achieved.
|Combination of an anti ED-B fibronectin domain antibody and gemcitabine - Disclosed is a combination of an anti edb fibronectin domain antibody and gemcitabine.
|Anti-M-CSF Antibody Compositions - The present invention provides for compositions of anti-M-CSF antibodies comprising a chelating agent and/or histidine. Also provided are methods of treating M-CSF-mediated disorders with pharmaceutical formulations of anti-M-CSF anti-bodies, including inflammatory diseases and neoplasia disorders.
|Antibody Having Inhibitory Effect on Amyloid Fibril Formation - Disclosed is an antibody having a high inhibitor effect on amyloid fibril formation. An antibody is produced by using a liposome containing a GM1 ganglioside at a predetermined ratio as an immunogen. Thus, the sequences of four types of antibodies each having a high inhibitory effect on amyloid fibril formation can be provided.
|MONOCLONAL ANTIBODIES AGAINST ACTIVATED PROTEIN C - The present invention provides monoclonal antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. Other antibodies inhibit both activated protein C and activation of unactivated protein C. Methods of treatment employing these antibodies are described herein as are methods of screening for and detecting these antibodies.
|Neutralizing monoclonal antibodies to respiratory syncytial virus - The present invention relates to the identification and cloning of a novel neutralizing human monoclonal antibody to the Respiratory Syncytial Virus. The invention provides such antibodies, fragments of such antibodies retaining RSV-binding ability, chimeric antibodies retaining RSV-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Finally, the invention provides for diagnostic and therapeutic methods employing the antibodies and nucleic acids of the invention.
|Treatment and prevention of viral infections - Disclosed is polynucleotide encoding a polypeptide comprising an antibody binding site, the polypeptide being able to bind to HCV E2 samples representative of each of HCV genotypes 1-6, as well as polypeptides having such properties and uses of such polypeptides in detecting and treating HCV infection.
|Antibodies against CCR5 and uses thereof - An antibody binding to CCR5 characterized in that the heavy chain variable domain comprises an amino acid sequence of SEQ ID NO: 1, and has advantageous properties for the treatment of immunosuppressive diseases.
|COMPOSITIONS AND METHODS RELATED TO TIM 3, A TH1-SPECIFIC CELL SURFACE MOLECULE - The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.
|COMBINATION THERAPY OF TYPE II ANTI-CD20 ANTIBODY WITH A PROTEASOME INHIBITOR - The present invention is directed to a combination therapy involving a type II anti-CD20 antibody and a proteasome inhibitor for the treatment of a patient suffering from cancer, particularly a CD20-expressing cancer.
|IMMUNOSUPPRESSION COMPOUND AND TREATMENT METHOD - A method and compound for suppressing an immune response in a mammalian subject, for the treatment or prevention of an autoimmune condition or transplantation rejection are disclosed. The compound is an antisense oligonucleotide analog compound having a targeting sequence complementary to a preprocessed CTLA-4 mRNA region identified by SEQ ID NO: 22 in SEQ ID NO: 1, spanning the splice junction between intron 1 and exon 2 of the preprocessed mRNA of the subject. The compound is effective, when administered to a subject, to form within host cells, a heteroduplex structure (i) composed of the preprocessed CTLA-4 mRNA and the oligonucleotide compound, (ii) characterized by a Tm of dissociation of at least 45° C., and (iii) resulting in an increased ratio of processed mRNA encoding ligand-independent CTLA-4 to processed mRNA encoding full-length CTLA-4.
|Hiv Gp120 Crystal Structure and Its Use to Identify Immunogens - The present disclosure relates to stabilized forms of the HIV gp120 envelope protein in complex with the broadly neutralizing CD4-binding site antibody b12, to crystalline forms of the stabilized forms of the HIV gp120 envelope protein in complex with the broadly neutralizing CD4-binding site antibody b12, and to the high resolution structure obtained from these crystals by X-ray diffraction methods. Methods for identifying immunogenic polypeptides based on these structures are also disclosed.
|Ehrlichia canis DIVA (Differentiate Infected from Vaccinated Animals) - The invention provides
|ISOLATED COMPLEXES OF ENDOTOXIN AND MODIFIED MD-2 - Applicants have produced and isolated water soluble complexes of endotoxin and modified MD-2.
|MULTIMERIC COMPLEXES OF ANTIGENS AND AN ADJUVANT - The invention relates to a product which comprises a C4bp domain of a non-mammalian origin, particularly SEQ ID NO:1, SEQ ID NO:23 or SEQ ID NO:37, or a variant thereof, and an antigen. The product is desirably in the form of a fusion protein. The chicken C4bp domain of SEQ ID NO:1 and SEQ ID NO:23 is also described. Antigens include monomeric antigens such as malarial and influenza antigens. The C4bp domain provides for assembly of multimeric complexes of the antigen, or mixtures thereof. The complexes are useful as vaccines.
|Anti-Inflammatory Proteins and Improved Vaccines - A recombinant poxvirus lacking a functional gene corresponding to BI4R in the WR strain of VACV for use as a medicament especially as a vaccine against a disease caused by a poxvirus or another pathogenic agent or for use as a medicament against a disease associated with aberrant cells. An isolated nucleotide or polypeptide encoding a poxvirus sequence corresponding to the sequence of B14 in the WR strain of VACV especially for use as a medicament against undesirable inflammation, immune activation or NF-κB activation. Related compositions and methods.
|Compositions Comprising a Recombinant Adenovirus and an Adjuvant - The invention relates to pharmaceutical compositions comprising replication-defective adenoviruses, said adenoviruses generally comprising an adenoviral genome wherein a heterologous nucleic acid of interest is incorporated, and wherein said nucleic acid typically encodes an antigen. Such compositions are suitable for vaccination purposes. The pharmaceutical compositions of the present invention further comprise an adjuvant, which stimulates and increases the immune response towards the antigen encoded by the heterologous nucleic acid. Preferred adjuvants are oil-emulsion based adjuvants and aluminium-based adjuvants.
|Mycobacterial SecA2 Mutants - Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are not
|INACTIVATED BOVINE HERPES VIRUS-1 AND METHODS - This invention related to a method of immunizing cattle to reduce the effects of infection by bovine herpes virus 1, including abortion and stillbirth, by administering inactivated bovine herpes virus 1 prior to breeding.
|METHOD OF DETERMINING VACCINE COMPLIANCE - A protein (xylanase) has been identified that produces a strong immune response in pigs when added to a vaccine. The protein is added to vaccines at a particular concentration. The protein is delivered to the animal as part of the vaccine and elicits an immune reaction (antibodies are generated by the animal against the compliance marker protein). The antibodies are then detected in sera samples by a diagnostic test, enzyme-linked immunosorbent assay (ELISA). In the ELISA compliance marker assay, the marker protein (antigen) in coated onto polystyrene plates and is used to detect antibodies against the marker in sera samples. This combination of marker protein added to vaccines and the ELISA to detect antibodies raised against the marker protein can be used to determine whether a particular animal(s) has been vaccinated. The selected protein is commercially-available, identified as Generally Recognized as Safe by the FDA, and does not cause adverse reactions in animals.
|Antigen-Adjuvant Compositions and Methods - Vitreous compositions of an antigen and adjuvant, and methods for making the compositions are disclosed. Also disclosed are pharmaceutically acceptable formulations of the vitreous compositions, reconstituted liquid formulations of the vitreous compositions, vaccine compositions, and kits containing the vitreous compositions. Also disclosed are devices for administering the vitreous compositions to mammals and methods for eliciting an immune response in mammals by administering the compositions.
|ACELLULAR IMMUNOGENIC COMPOSITIONS AND ACELLULAR VACCINE COMPOSITIONS AGAINST BACILLUS ANTHRACIS - The invention concerns an acellular immunogenic or vaccine composition for producing antibodies against
|T-CELL MODULATION - The invention provides methods and materials for use in modulating T cell activation, based on the production and secretion of soluble cytotoxic T-lymphocyte antigen-4 (sCTLA-4) by cells of the immune system. The method involves stimulating secretion of endogenous sCTLA-4 by T cells, which have preferably previously been exposed to an antigen, by exposing the said cells to a stimulatory agent, preferably a peptide which comprises at least one antigenic determinant of said antigen. The cells may also be exposed to a CD28 stimulatory binding agent, either alone or in combination with the antigenic peptide. In preferred embodiments, the method may be used for treatment or prophylaxis of a disease characterized by a pathogenic immune or autoimmune response. The invention also provides a system for inhibiting sCTLA-4 secretion by T cells.
|Mesothelin Vaccines and Model Systems and Control of Tumors - Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell response include bacteria and viruses. A mouse model for testing vaccines and other anti-tumor therapeutics and prophylactics comprises a strongly mesothelin-expressing, transformed peritoneal cell line.
|Cosmetic composition comprising polyorganosiloxane and uses thereof - The invention relates to a cosmetic composition comprising a cosmetically acceptable vector and polyorganosiloxane. The polyorganosiloxane comprises a group that includes a sterically hindered amine.
|COSMETIC COMPOSITION BASED ON A MAGNETIC OR MAGNETISABLE MATERIAL, THE PREPARATION THEREOF AND USE THEREOF FOR CLEANSING THE EPIDERMIS - The present invention relates to a cosmetic composition based on a magnetic or magnetisable material, the preparation thereof and use thereof for surface and deep cleansing of the epidermis. Said cosmetic composition has revealed to be particularly useful for preparing a mask for cleansing the epidermis of the face, breast, hands and body and, simultaneously, for maintaining the aesthetic appearance and functional efficiency thereof.
|MOISTURIZERS COMPRISING ONE OR MORE OF gamma-POLYGLUTAMIC ACID (gamma-PGA, H FORM), gamma-POLYGLUTAMATES AND gamma-POLYGLUTAMATE HYDROGELS FOR USE IN COSMETIC OR PERSONAL CARE PRODUCTS - The present invention relates to a moisturizer comprising γ-polyglutamic acid (γ-PGA, H form), and/or one or more of its salts (i.e., γ-polyglutamate in Na
|PAIN RELIEF COMPOSITION AND UTILIZATION THEREOF - A titanium-impregnated tape uses a material treated by fine dispersion water containing citric acid or its salt in which fine metal titanium particles are dispersed. The titanium-impregnated tape provides a physiological structure that acts upon the function to interfere with the pain memory system affecting neurons.
|Methods for Producing Pesticide Compositions - Disclosed are compositions and methods related to powder and granular emulsifiable concentrate pesticide formulations. As disclosed, emulsions from non-aqueous based liquid or solvent soluble pesticide actives may be prepared using a high purity, high molecular weight sulfonated lignin as the emulsion stabilizer. The resulting emulsions may then be dried to obtain a powder or granular emulsion concentrate where the high molecular weight sulfonated lignin acts as a solid matrix for the pesticide active. The powder or granular emulsifiable concentrate formulations thus formed have high loading rates, good storage properties and are easily reconstituted when added to water.
|ANIMATE TISSUE ANTISEPSIS - A method and device provide for inactivating microorganisms on tissue exposed through a surgical incision. The method includes the steps of: applying a coating of a solution comprising hydrogen peroxide to the tissue; and force drying the solution on the tissue so as to concentrate the solution on the tissue. The concentrated solution kills microorganisms.
|ELASTIN PROTECTIVE POLYPHENOLICS AND METHODS OF USING THE SAME - Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.
|DEVICES AND METHODS FOR TREATING DEFECTS IN THE TISSUE OF A LIVING BEING - An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may be "matched" to provide the implant with similar physical and/or chemical properties as the host tissue.
|IMPLANTABLE DEVICE HAVING A SLOW DISSOLVING POLYMER - The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.
|Methods and systems for use of photolyzable nitric oxide donors - The present disclosure relates to methods and systems for use of photolyzable nitric oxide donors for the treatment of sexual dysfunction.
|Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices - The present invention is directed to polymeric materials (e.g., coatings) comprising biodegradable copolymers and implantable devices (e.g., drug-delivery stents) formed of such materials. The biodegradable copolymers are derived from at least two relatively polar monomers and at least one relatively nonpolar monomer. Incorporation of at least one relatively nonpolar monomer into the copolymer improves controlled release of a hydrophobic drug from the polymeric material by increasing the copolymer's miscibility with and permeability to the hydrophobic drug. The polymeric materials can also contain at least one biocompatible moiety, at least one non-fouling moiety, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric materials are designed to improve the mechanical, physical and biological properties of implantable devices formed thereof.
|Medical or veterinary digestive tract utilization systems and methods - Systems and methods are described for implementing or deploying medical or veterinary utility modules comprising a first module operable in a digestive or respiratory tract to engage a second module, optionally by a magnetic field. Alternatively or additionally, systems may be operable to remain in situ and also operable to permit a therapeutic material dispensation. In some contexts, for example, systems or methods may dispense a therapeutic material via a subject's throat or elsewhere in the digestive or respiratory tract.
|Edible film Package Having Product for Oral Intake Enclosed Therein - This invention aims to provide a novel taking or having-or-swallowing form for an oral material, such as drugs or foodstuffs.
|ORALLY DISINTEGRATIVE DOSAGE FORM - The present invention features an orally disintegrating dosage form including from about 5% to about 40%, by weight, of at least one hydrated salt and a pharmaceutically active agent, wherein the at least hydrated salt has a dehydration temperature of from about 20 to about 120° C.
|TRANSMUCOSAL COMPOSITION - The invention provides a composition for delivering active agents through transmucosal administration, more particularly through the buccal mucosa. The composition is a unique transmucosal disk (
|Derivatives of tiacumicin B as anti-cancer agents - New derivatives of tiacumicin B are disclosed and are presented by the general formula:
|Polyamine modified particles - A particle composition comprising a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, and a combinatorial delivery polymer comprising a plurality of particles that comprises a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, a plurality of nucleic acids electrostatically loaded onto the particles, a plurality of chemokine molecules, and a biodegradable polymer network, in which the loaded particles and chemokine molecules may be entrapped, are disclosed. Also disclosed is a method for treating a subject comprising administering a therapeutically effective dose of a pharmaceutical composition, the pharmaceutical composition comprising a particle composition that comprises a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer.
|Use of compounds for the prevention of drug-induced cell toxicity - The present invention relates to the use of compounds for the manufacture of a medicament for the prophylaxis and/or treatment of induced cell toxicity, such as nephewrotoxicity and ototoxicity, in particular where the cell toxicity is induced by a medical treatment. In a preferred embodiment, the compounds have at least two nitrogen atoms, more preferably at least two amino groups. The compounds according to the invention are capable of docking binding of cell toxic compounds to the megalin receptor, and thereby inhibiting uptake of the cell toxic compounds into cells. The invention further relates to novel compounds for use in said treatment, as well as a method for reducing the cell toxicity of cell toxic compounds.
|Paneled capsule shells for release of pharmaceutical compositions - Capsule shells for use in multi-part dosage forms have generally cylindrical shell members with a snap fit component on an interior surface adjacent an open end, for connection to a linker part of the dosage form. The shell member also has a plurality of spaced apart integrally formed thin (relative to circumferentially adjacent shell member portions) panels located adjacent a closed shell member end, for preferential dissolution and release of pharmaceutical compositions from the shell member interior. The ratio of the thickness of the panels to the thickness of the shell member ranges from about 0.2 to about 0.6. The panels can be integrally formed together with the shell member as reliefs or depressions on the inner surface of the shell member by injection molding, and panel thicknesses as thin as about 0.1 mm can be achieved,
|Composition - A pharmaceutical composition comprising licarbazepine acetate, especially eslicarbazepine acetate, in combination with suitable excipients, in particular a binder, and a disintegrant. Also disclosed is a granulation process, especially a wet granulation process, for making the pharmaceutical composition.
|Linkers for multipart dosage forms for release of one or more pharmaceutical compositions, and the resulting dosage forms - A linker for multicomponent dosage form has a preformed drug substance tablet and an injection molded jacket including one or both axial jacket ends open for dispensing the preformed drug substances. The jacket has snap-fit connection elements on the outer surface adjacent each end for engagement with complementary snap-fit element on capsule-type and cap-type dosage form units. Another multicomponent drug form linker is injection molded with a raised circumferential band and snap-fit elements between the band and respective ends engageable with complementary snap-fit elements on dosage form units to provide compressive abutting contact between ends of the units and the band. The band can have an axially tapered outer surface to accommodate dosage form units of different diameters. Still another multicomponent dosage form linker has separable male and female parts each engageable with, and separately sealing, respective dosage form units to be linked. Circumferential complementary grooves, groove segments, ridges and ridge segment-type snap-fit elements are disclosed, as are dosage forms using the above-described linkers.
|COMPOSITIONS AND METHODS FOR TREATMENT OF PAIN - The present invention relates to compositions and methods for treatment of various forms of pain. Specifically, the method involves administering to a patient a composition comprising butalbital, acetaminophen and caffeine in the gelcap dosage form, to treat and/or alleviate the occurrence or negative effects of various forms of headaches.
|SOLID, ORODISPERSIBLE AND/OR DISPERSIBLE COMPOSITION, WITHOUT AN EXCIPIENT OF KNOWN EFFECT AND ITS PROCESS OF PREPARATION - The present invention relates to a solid, orodispersible and/or dispersible composition comprising (a) from 0.1 to 59% by weight of at least one active substance with particle size not exceeding 50 μm; (b) from 40 to 99% by weight of at least one diluent without known effect, non water-soluble; (c) from 0.1 to 15% by weight of at least one disintegrating agent; and (d) from 0.05 to 10% by weight at least of one sweetening agent with particle size not exceeding 50 μm, percentages by weight being expressed compared to the total weight of the aforementioned composition. The present invention also relates to the use of said composition as a drug, a food supplement or in cosmetics and a method of preparation of an orodispersible and/or dispersible compound implementing said composition.
|FORMULATION HAVING ACCURATE DOSE-DIVIDING FUNCTION - The present invention provides a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, and having a scored line capable of dividing the whole tablet on the connecting part; particularly, a coated tablet in which a connecting part and a coating layer have the same or different drug release controlling functions; a tablet having an insoluble coating on a drug-containing part having a scored line, wherein the drug-containing part has a structure or composition such that the drug is substantially released after the tablet is divided along the scored line and then ingested; and a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, wherein at least two drug-containing parts have different compositions.
|Extended release compositions of proton pump inhibitors - The invention provides extended release compositions comprising at least one proton pump inhibitor. The invention also provides methods for treating gastrointestinal disorders by administering the compositions of the invention to patients in need of gastrointestinal therapy.
|Zero-Order Modified Release Solid Dosage Forms - The invention comprises a solid dosage form for delivery of water soluble pharmaceutical agents. The solid dosage form comprises a matrix core containing the pharmaceutical agent and a hydrophobic material, and a coating containing a hydrophilic pore-forming agent and a hydrophobic polymer. The dosage form exhibits a zero-order release profile upon dissolution.
|SOLID ORAL COMPOSITIONS BASED ON S-ADENOSYL METHIONINE AND/OR NADH AND PROCESS FOR OBTAINING THEM - This invention relates to solid oral compositions based on SAMe and/or NADH or their salts in association with calcium oxide and/or calcium hydroxide and a process for obtaining them.
|Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same - The present invention relates to the use of certain microspheres, nanospheres, and other structures to provide a method of marking or masking identifying marks in individual biological hosts. Biological hosts for the present invention may include humans, other animals, or plants. Such methods may be used to sense, signal, track, mark, or identify individual biological hosts. Microspheres, nanospheres, and other structures of the present invention may be implanted, injected, ingested, or attached to individual biological hosts. Microspheres, nanospheres, and other structures of the present invention comprise poly[bis(trifluoroethoxy)phosphazene] and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The microspheres, nanospheres, and other structures may also comprise a core having a hydrogel which may further comprise one or more dyes or other chromophoric agents covalently bound permanently to the hydrogel core material. The microspheres, nanospheres, and other structures and/or the hydrogel core may further comprise radio frequency or other electronic chips or nanochips, capable of transmitting and/or receiving electronic signals from external transmitters and/or receivers.
|Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same - Particles are provided for use in restorative procedures to treat and/or retard alopecia The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in various colors or with customized coloration to match desired scalp colors. Moreover, such particles may be loaded to provide localized treatment with an active component agent directed at restoration of normal function and hair production within the hair follicle.
|BIORESORBABLE COMPOSITION FOR REPAIRING SKELETAL TISSUE - Bioresorbable compositions for treating skeletal tissue are disclosed. The biomedical compositions are formed from a polylactide polymer, a polyglycolide polymer, or a poly(lactic-co-glycolic acid) polymer having a relatively low molecular weight. For instance, the average number molecular weight of the polymer is generally less than 10,000, such as from about 500 to about 5,000. Fumarate groups are incorporated into the low molecular weight polymer that provide crosslinking sites. If desired, ethylene oxide groups and ceramic particles may also be incorporated into the polymer for producing compositions having a variety of properties. For example, the biomedical composition of the present disclosure can be used to treat soft skeletal tissue or to treat hard skeletal tissue. The biomedical compositions are biodegradable and can contain various therapeutic, beneficial and pharmaceutical agents that may be released during degradation of the polymer.
|DELIVERY MEANS - A delivery means for delivering a deliverable material to a wound bed comprises a hydrogel (preferably an optionally cross-linked polyvinylalcohol) and a deliverable material comprising: (i) a decomposable material which in the absence of said hydrogel decomposes and/or is permanently denatured if sterilised using heat, electron beam radiation or gamma radiation; (ii) a protein, protein fragment, peptide or amino acid; or (iii) a secretion or excretion from the organism
|QUATERNISED AMMONIUM CYCLODEXTRIN COMPOUNDS - Use of a compound of formula (I):
|CONTROLLED RELEASE FORMULATIONS - The present invention provides stable, self-assembling, biocompatible and biodegradable hydrogel formulations, into which one or more compounds may be incorporated allowing for delayed release or controlled release of the incorporated compounds as the hydrogel is degraded in the body.
|ALLOPLASTIC INJECTABLE DERMAL FILLER AND METHODS OF USE THEREOF - A composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent is provided. A method of making a composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent, said method comprising admixing a biocompatible and pliable material with a physiologically acceptable suspending agent, is also provided. A method of augmenting soft tissue to provide long-term reduction of a skin defect, said method comprising stimulating collagen beneath the skin defect is further provided. In an embodiment of the method of augmenting soft tissue, the stimulation of collagen production is effected by injecting into the deep reticular dermis an a dermal filler, said dermal filler being an alloplastic injectable suspension and comprising a biocompatible and pliable material and a physiologically acceptable suspending agent.
|Orally Disintegrating Powder Comprising Cilostazol and Mannitol - The present invention provides an orally disintegrating powder comprising cilostazol as an active ingredient and mannitol in an amount of 70% by weight or more, which can be taken without water and can be disintegrated in oral cavity. Said powder is suitable for patients to whom cilostazol is applied, especially for aged patients and patients suffering from dysphagia.
|Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same - Particles are provided for use in therapeutic cosmetic and/or reconstructive procedures to augment defects in tissue to restore contours and/or function. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in various colors or with customized coloration to match desired tissues. Moreover, such particles may be loaded to provide localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided or used in conjunction with tissue adhesives or photoinitiator agents that may be activated by electromagnetic radiation or other energy sources to allow post-implantation cross-linking of the polymeric particles to cause their amalgamation to maintain their shape and location following implantation.
|Targeted cancer chemotherapy using synthetic nanoparticles - Compositions and methods for delivery of a pharmaceutical to an individual. Delivery vehicles are provided in a formulation of a pharmaceutical that is encapsulated in a synthetic self assembled nanoparticle that includes a lipid binding protein and a lipid monolayer. The interior of the particle represents a hydrophobic core region where lipophilic highly-water insoluble drug molecules may be incorporated. In contrast to liposomes, that include an aqueous interior core surrounded by phospholipid bilayer, the drug carrier nanoparticle described here is composed of a monolayer and a hydrophobic interior.
|Materials and Methods for Modulating Metabolism - The subject invention provides materials and methods for modulating a variety of biological factors to treat biological conditions associated with the factors. In one embodiment of the invention, a cysteamine compound is administered to a patient to treat hypercholesterolemia and/or complications associated with hypercholesterolemia. In another embodiment, a cysteamine compound is administered to a patient to prevent the onset of diabetes in an at-risk patient and/or treat or prevent the onset of diabetes-associated complications.
|METHOD AND COMPOSITIONS FOR POLYMER NANOCARRIERS CONTAINING THERAPEUTIC MOLECULES - A method of controlling a physical characteristic of polymeric nanocarrier-encapsulated protein particles includes altering or selecting a weight percentage of a hydrophobic polymer block in a total amphiphilic diblock copolymer of a primary emulsion of a double emulsion, freeze-thaw technique. The primary emulsion is formed using a freeze-thaw cycle of the amphiphilic diblock copolymer and a protein having a molecular weight of up to or equal to 300,000 Da. Selection of the hydrophobic polymer block percentage alters one or more characteristics of the resulting nanoparticles, such as shape. Thus, as one aspect, a method of producing filamentous polymeric nanocarrier-encapsulated protein (i.e., active enzyme) particles involves forming a primary emulsion using a freeze-thaw cycle of (i) an amphiphilic diblock copolymer, which has a molecular weight of about 10,000 to about 100,000 Da and comprises a conjugate of the hydrophobic polymer block and a hydrophilic polymer block, wherein the amphiphilic diblock copolymer comprises greater than 81% to about 95% by weight of the hydrophobic polymer block; and a protein having a molecular weight of up to or equal to about 300,000 Da. Various compositions comprising such filamentous-shaped nanocarrier particles, and methods of use for diagnosis and therapy are disclosed.
|Long-acting colloidal insulin formulation and its preparation - The invention relates to injectable long-acting insulin formulations for the treatment of types I and II diabetes in humans and animals.
|Porous beta-tricalcium phosphate granules and methods for producing same - A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous β-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous β-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous β-TCP material and inducing bone formation are also provided.
|SUSTAINED RELEASE PHARMACEUTICAL COMPOSITIONS - A sustained release microsphere composition comprising—
|Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging - The present invention provides methods for improving cognitive function, improving mood, and decreasing aggression in a normal adult subject, and in a subject having symptoms characteristic of a neurological disorder, by administration of a nutriceutical formulation of the invention to the subject. The invention additionally features methods of treating neurological disorders, depression, and aggression using nutriceutical formulations. Nutriceutical compositions and formulations for use in the methods of the invention, and kits containing nutriceutical compositions and formulations, are also provided.
|New class of therapeutics that enhance small modecule diffusion - The subject invention relates to novel compositions containing a diffusion enhancing compound and their use in treating a variety of disorders.
|DRUG AND/OR FOOD SUPPLEMENT CONTAINING NISYLEN R, CEPA, EUPHRASIA, BELLADONA AND/OR MERCURIUS SOLUBILIS - The present disclosure relates to a drug and/or food supplement with antiviral effects, in particular for the preventive and/or therapeutic treatment of herpes labialis and/or herpes genitalis, and/or with antibacterial and/or immunomodulating and/or antiphlogistic effects and/or for the preventive and/or therapeutic treatment of affections of the prostate, containing NISYLEN® and/or Cepa and/or Euphrasia and/or Belladonna and/or Mercurius solubilis.
|Biocompatible Material and Process for Manufacturing the Same - In order to provide a biocompatible material consisting mainly of a fish scale-derived hydroxyapatite and a fish scale-derived collagen, which is adjusted so that easily digested and absorbed in a human body, the material contains a composite consisting mainly of a fish scale-derived hydroxyapatite and a fish scale-derived collagen.
|Method and apparatus for producing a stabilized antimicrobial non-toxic electrolyzed saline solution exhibiting potential as a therapeutic - An improved method and apparatus is disclosed for producing a stable, non-toxic, antimicrobial electrolyzed saline solution with a broad range of anti-infective and therapeutic applications. The resulting solution is balanced to normal and hypertonic saline and has been shown to exhibit remarkable antimicrobial, antiviral and therapeutic characteristics. The nature of this solution makes it suitable for applications in food safety, animal health, agriculture and sterilization. The solution also exhibits a marked lack of toxicity upon intravenous, aspired, oral or topical application in mammals. The therapeutic applications represent a broad platform, possibly covering a variety of potential areas of use, including topical disinfection, antimicrobial application, wound treatment, oxidative stress reduction and enhancement of immune function to better detect malfunctioning cells.
|Antimicrobial Materials - A material for the treatment or prophylaxis of microbial, including bacterial, infections, comprising a metal species and a polymer, wherein the polymer stabilises the metal species. Compositions and devices comprising the material. A method for the treatment or prophylaxis of microbial, including bacterial, infections, comprising the use of such a material, composition or device.
|Compositions and Methods for Treatment of Diseases of the Foot of an Animal - The present invention is directed to an activator composition comprising copper sulfate, zinc sulfate, sodium chloride, and ammonium sulfate, for the activation of an anti-microbial composition. The resulting activated anti-microbial composition is used for the treatment of an infectious disease of a foot of an animal, particularly for the use of ungulates. Benefits of using the activator composition, either alone or in conjunction with other anti-microbial compositions, include the reduction of copper deposited into the environment from anti-microbial treatments, extended use of an anti-microbial composition, and maintenance of low levels of infectious diseases of the feet of animals.
|COMPOSITION FOR CONTROLLING BLOOD GLUCOSE AND METHOD THEREOF - A composition for controlling a blood glucose and a method thereof are provided. The composition comprises a far-infrared ray releasing substance, wherein the composition reduces the blood glucose of a subject via an irradiation of the far-infrared ray releasing substance. In another aspect, the method comprises the steps of providing a far-infrared ray releasing substance having an oxide mineral as a main component, and disposing the far-infrared ray releasing substance in a place close to a subject in an appropriate distance, wherein the subject has an insulin resistance and the appropriate distance is within an irradiation range of the far infrared ray.
|Enzyme-cleavable prodrug compounds - The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention.
|Stabilized Chlorine Dioxide and Hypochlorous Acid in a Liquid Biocide - A liquid biocide containing stabilized chlorine dioxide and hypochlorous acid for various uses, including use as a teat dip or dairy animals. The stable, prophylactic biocide consists essentially of 0.10-20.0% by weight of a chlorite salt, 0.1-3.0% by weight of an acid, 0.10-2.0% by weight of an alkaline agent, and the balance water. Chlorite salt reacts with the acid to form germicidal chlorine dioxide and hypochlorous acid. The acid constituency and the alkaline agent constituency regulate the pH of the solution such that the biocide is stable when mixed for a period greater than two months. The present disclosure also includes a method of producing a stable, prophylactic biocide for dairy cattle, the method comprising 0.10-20.0% by weight of a chlorite salt, 0.10-3.0% by weight of an acid, 0.10-2.0% by weight of an alkaline agent, and the balance water in a container, and sealing the container. In the method, the acid and alkaline agent constituencies regulate the pH of the solution such that the formation of hydronium ions from the acid is correspondingly regulated to stabilize the solution for a period greater than two months from the date of sealing.
|Compositions and Methods for Preventing Migraines - The present invention relates to compositions and methods for preventing migraines. The migraine prophylaxis composition is a single dosage form comprising at least one form of elemental magnesium and at least one NSAID. The prophylaxis composition, comprising at least one form of elemental magnesium and a therapeutically effective concentration of acetylsalicylic acid may also provide cardiac protection and prevent cardiovascular diseases.
|Methods and Compositions Related to PLUNC Surfactant Polypeptides - Embodiments include compositions and methods for lower the surface tension of a liquid-air interface by contacting such interface with all or part of a PLUNC polypeptide.
|Methods for modulating eicosanoid metabolism - The inventive subject matter relates to methods for treating prostate cancer, comprising administration of a composition comprising therapeutically effective amounts of supercritical extracts of rosemary, turmeric, oregano and ginger; and therapeutically effective amounts of hydroalcoholic extracts of holy basil, ginger, turmeric,
|COMPOSITIONS AND METHODS FOR PROMOTING WEIGHT LOSS - Compositions, which include psyllium and polyethylene glycol in a weight ratio of psyllium to polyethylene glycol of from about 1:3 to about 2:1, a gum, and one or more additional ingredients selected from the group consisting of water, salt, sweeteners, flavoring agents, and preservatives are presented.
|Pharmaceutical Composition for Use as a Laxative - The invention relates to a pharmaceutical composition which is suitable in particular for use as purgative (cathartic), where the composition comprises in combination and in each case in pharmaceutically effective amounts (A) senna fruit dry extract and (B) plantago seeds (plantaginis ovatae semen). The composition can advantageously be manufactured by fluidized bed granulation. The composition is in particular free of guar gum, is dust-free, is dispersible in water and has a pleasant taste and can be supplemented straightforwardly with vitamins, minerals, trace elements and the like.
|Lipometabolism improver containing pine bark extract - As a lipid metabolism improving agent for allowing lipids in the body to be metabolized efficiently, a lipid metabolism improving agent containing a pine bark extract as an active component is provided. The lipid metabolism improving agent of the present invention has abilities to promote cholesterol excretion, inhibit lipid absorption, reduce body fat, and inhibit fat accumulation, and the like.
|Extrusion Molding Apparatus for Resin Tube - The dimensions of a tube molded by an extrusion molding apparatus are made more accurate. The arrangement of the extrusion molding apparatus enabling the molding of the aforesaid accurate tube is simplified. The molding of the aforesaid accurate tube is facilitated. The extrusion molding apparatus (
|Hot runner having reduced valve-stem drool - Disclosed is a valve-gated hot-runner system, having: (i) a back-up sealing arrangement, including: (i) a plurality of radial gaps associated with a valve stem of a valve actuator, and (ii) a cooling system being positioned relative to the plurality of radial gaps, the cooling system being configured to freeze a drool being made to enter, under pressure, into the plurality of radial gaps, so that the drool that becomes frozen substantially reduces flow of the drool along the valve stem and toward the valve actuator.
|Material Delivery Tension and Tracking System for Use in Solid Imaging - A solid imaging apparatus and method employing a radiation transparent build material carrier and a build material dispensing system that accurately controls the thickness of the transferred layer of solidifiable liquid build material to the radiation transparent build material carrier to achieve high resolution imaging in three-dimensional objects built using an electro-optical radiation source.
|REPLACEABLE DOUBLE-PLATE-INJECTION MOLD - A replaceable double-plate-injection mold comprises a movable side mold plate having one side formed with a male mold core; a movable side assembly plate being connected to another side of the movable side mold plate; a fixed side mold plate having one side being formed with a female mold core; and a fixed side assembly plate having one side installed with a plurality of track supporting rods for passing through the fixed side mold plate, the movable side mold plate, and the movable side assembly plate. One side of the fixed side assembly plate is recessed for assembling a supporting plate of the male mold core; and another side thereof is corresponding to the fixed side assembly plate. A center of the movable side mold plate is formed with a receiving portion.
|Hot runner nozzle system - Disclosed is a hot-runner nozzle system, including: (i) a nozzle housing being configured to convey a molten molding material, (ii) a sieve being coupled with the nozzle housing, (iii) a nozzle tip being securely coupled relative to the sieve, and (iv) a retainer securely extending from the sieve, the retainer connecting with the nozzle tip.
|Coupling for Pelleting Mill - A pelleting die assembly includes a tubular die that is rotated by a quill flange. During rotation, particulate material inside the tubular die is extruded through extrusion holes by rollers inside the tubular die. The die is coupled to the quill flange by a flat, annular disc having one side attached to the die by bolts and an opposite side attached to the quill flange by other bolts. The bolts extend axially through the annular disc and face in opposite directions. The annular disc may include grooves to allow cyclic deflection of the die in a radially outward direction while reducing cyclic loading and strain on the quill flange.
|MOLD FOR INJECTION MOLDING - A mold for injection molding includes a male mold portion, and a female mold portion mating with the male mold portion to define a parting face therebetween. The female mold includes a mold cavity defined at the parting face, an injection aperture communicated with the mold cavity, an air channel defined at the parting face and evenly spaced from and partially surrounding the mold cavity, a spacing portion formed between the mold cavity and the air channel, and a gap formed between the male mold portion and the spacing portion for transmitting air from the mold cavity to the air channel during injection of molten plastic. When injecting molten plastic, air in the mold cavity can be expelled in time under pressure of the molten plastic and through the air channel. Therefore, the surface quality of the molded product can be improved, by avoiding formation of air holes, fissure.
|Microbiocidal Control in the Processing of Meat-Producing Four-Legged Animals - Methods of processing four-legged slaughter animals for consumption as meat and/or meat product(s) are described. The methods comprise: I) contacting exterior surfaces of the live animal at least once with a microbiocidal solution formed from mixing together at least (i) water and (ii) at least one 1,3-dibromo-5,5-dialkylhydantoin, such contacting occurring at least once when the animal is en route to being slaughtered but before it is killed by exsanguination; or II) contacting the carcass of the animal, after exsanguination, with a microbiocidal solution formed from mixing together at least (i) water and (ii) at least one 1,3-dibromo-5,5-dialkylhydantoin or III) contacting at least one raw meat product and/or at least one processed meat product derived from the carcass. The contacting can be done one or more times in each of I), II), and III). Considerable advantages, which are described, are realized when using such methods.
|Process for Producing Fermented Beverages Using Fermentation Raw Material Solutions of Low Maltotriose Ratio - It is an object of the present invention to provide fermented beverages that give no sweetness in aftertaste and which have less off-flavors by a technique that will not affect the principal taste and aroma characteristics and which is highly acceptable to consumers.
|Galactosidase With Alpha-Galactosyltransferase Activity - The present invention concerns a β-galactosidase with transgalactosylating activity isolated from
|SUGAR FREE LOW CALORIE SYRUP AND THE MANUFACTURING METHOD THEREOF - The invention concerns sugar-free syrup of low calories and a method of producing the same, which syrup is of low calories and is a healthy substitute of sugar because it has almost no calories but contains a lot of edible fiber. To this end, the sugar-free syrup of low calories according to one aspect of the invention is characterized in that it consists of 100 parts by weight of water-soluble edible fiber, 100 to 200 parts by weight of water, 0.2 to 2 parts by weight of gum, 0.2 to 2 parts by weight of natural stabilizer and a proper amount of sweetener. Also, a method of producing the sugar-free syrup of low calories according to another aspect of the invention is characterized in that it comprises the steps of adding 100 to 200 parts by weight of water to 100 parts by weight of water-soluble, edible fiber and then dissolving the mixture at 50° C. to 80° C. while agitating it, adding 0.2 to 2 parts by weight of gum when the water-soluble fiber is fully dissolved, and then dissolving the mixture while agitating it, adding 0.2 to 2 parts by weight of natural stabilizer when the gum is fully dissolved, and dissolving the mixture while agitating it, adding a proper amount of sweetener to the mixture and dissolving the resulting mixture, and then cooling it by placing the mixture at a room temperature
|WATER SOLUBILIZATION OF CELLULOSICS AND RELATED COMPOUNDS - The present invention is directed toward a method of solubilizing melaninic, ligninic, chitinic, and/or cellulosic material. The method includes providing melaninic, ligninic, chitinic, and/or cellulosic material and providing an oxoacid ester of phosphorus or a mixture of an oxoacid of phosphorus and an alcohol. A blend of the melaninic, ligninic, chitinic, and/or cellulosic material, the oxoacid ester of phosphorus or the mixture of the oxoacid of phosphorus and alcohol is formed. The blend is then treated under conditions effective to solubilize the melaninic, ligninic, chitinic, and/or cellulosic material.
|Fruit Snack with Probiotics and Method of Manufacturing a Fruit Snack with Probiotics - A fruit snack with probiotics that is stable at room temperature is manufactured by combining various ingredients including fruit juices/purees to produce a slurry and cooking the slurry to produce a center that contains a high moisture content. The fruit snack center is covered with a barrier layer which in turn is covered by an outer layer that contains heat sensitive ingredients, such as probiotic cultures. The barrier layer substantially prevents migration of moisture from the center to the outer layer, and the fruit snack is cooled prior to applying the outer layer to minimize damage/harm to the heat sensitive ingredients. In addition to including probiotic cultures and being stable at room temperature, the fruit snack has other desirable characteristics including a chewy soft texture and fruit-flavorings, and may be manufactured using traditional processes.
|HIGH ANTIOXIDANT LEVELS IN COCOA-BASED BEVERAGES - The invention provides, in one aspect, a method of producing a ready-to-drink cocoa beverage containing high levels of beneficial cocoa polyphenols in a milk or soymilk base. The method incorporates an ultra high temperature treatment followed by a homogenization step. Cocoa powder levels can be selected from about 3.5% to about 10% by weight, while the mouthfeel, solution stability over time, and taste remain acceptable.
|DISPOSABLE CARTRIDGE FOR USE IN A BEVERAGE MAKER, COMPRISING A NOVABLY ARRANGED NEEDLE MEMBER - A disposable cartridge (
|STAND-ALONE HOT-PREPARATION DEVICE FOR CONVENIENCE FOOD PRODUCTS, PARTICULARLY INSTANT HOT BEVERAGE MAKER - A stand-alone hot-preparation device for convenience food products, particularly instant beverage maker, includes


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Payment Reform Evaluation: Lessons from State and Regional Efforts
What's Happening in Vermont?
Vermont's new "All Payer Model" is changing how hospitals and providers are paid for health care statewide.
Health care leaders, policymakers, and researchers agree that health services delivery in the United States is in need of major change. Most experts believe many problems with the health care system can be attributed to compensation models which misalign financial incentives lead to undesirable outcomes. Recognizing these issues, various organizations seek to realign financial incentives with the goals of improving quality and enhancing value.
The Robert Wood Johnson Foundation awarded two grants to the University of Washington to perform cross-cutting evaluation of twelve payment reform efforts. These efforts were designed to promote high-value health care outcomes through leveraging existing market knowledge, partnerships and resources in different states and regions of the United States. Both evaluations draw lessons by comparing and contrasting implementation processes and outcomes of the projects.
- Payment Reform Evaluation Project 1 (2011-2013) studied eight projects in Maine, New Hampshire, Massachusetts, Pennsylvania, Oregon, and Washington.
- Payment Reform Evaluation Project 2 (2013-2015) is studying four projects in Vermont, Pennsylvania, Oregon and Washington.


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'One Night Stand: Creating a Play in a Day' to stream in 2 local movie theaters
Giving audiences an unbridled and candid look behind the scenes of the Broadway curtain, NCM Fathom Events, Overnight Musicals and The Broadway League present "One Night Stand: Creating a Play in a Day," a unique one-night event broadcast to movie theaters nationwide on Wednesday, Jan. 30 at 7:30 p.m. local time. (Two participating local theaters are Quality 16, at 3686 Jackson Road, and Rave Motion Pictures, at 4100 Carpenter Road.)
This film follows some of New York's top actors, including Cheyenne Jackson ("30 Rock," "Glee"), Jesse Tyler Ferguson ("Modern Family") and Rachel Dratch ("Saturday Night Live"), as well as teams of writers, composers and directors as they are given 24 hours to write, cast, compose, rehearse and perform four short musicals. At the end of the 24 hours, the musicals make their opening, and closing, night at New York City's Gramercy Theatre. The event will also present exclusive behind-the-scenes footage and interviews with the stars of "One Night Stand" as they share intimate stories of life on Broadway.
Tickets for "One Night Stand: Creating a Play in a Day" are available at participating theater box offices and online at www.FathomEvents.com. For a complete list of theater locations and prices, visit the NCM Fathom Events website (theaters and participants are subject to change). The event will be broadcast to nearly 450 select movie theaters across the country through NCM's exclusive Digital Broadcast Network.
Likened to "'A Chorus Line' meets 'Project Runway'" (by BroadwayWorld.com), "One Night Stand: Creating a Play in a Day," directed by Elisabeth Sperling and Trish Dalton, captures the excitement, anxiety, camaraderie and sheer panic that leads to the final thrill of the finished performance. From the blank page to the live stage, "One Night Stand: Creating a Play in a Day" unveils the magic as these talented artists take the dare to create something from nothing.
Four teams consisting of composers, writers, directors and actors use props to inspire the musicals: a zoot suit worn by Richard Kind ("Argo," "Spin City," "Mad About You") on a children's show in the 1970s inspires the "Islands" musical; a phobia pop-up book is the premise for "Multiphobia"; and an '80s prom dress prop is used in "Dr. Williams" featuring Jackson, Ferguson and Roger Bart ("Revenge," "Desperate Housewives"). Dratch brings her comedic timing to the fourth musical, "Rachel said Sorry."
"I love the whole process of birthing a new musical, from the first rehearsal until opening night, and 'One Night Stand' shows it all encapsulated in one day," said Ferguson in a press release. "It's just so exciting and really quite moving - a crazy birth in one night! You get to see some amazing New York talent on stage, me included."
Actors featured in the musicals include the aforementioned Bart, Dratch, Ferguson, Jackson and Kind as well as Mandy Gonzalez ("Wicked," "In the Heights"); Capathia Jenkins ("Newsies," "Chicago," "Nine"); Theresa McCarthy ("Queen of the Mist," "Saturn Returns," "Titanic"); Nellie McKay ("Home Sweet Mobile Home," "Rumor Has It"); Marnie Schulenburg ("As the World Turns"); Scarlet Strallen ("Mary Poppins," "The Witches of Eastwick"); Tracie Thoms ("Cold Case," "Rent"); Tamara Tunie ("Law and Order SVU," "Flight") and Alicia Witt ("Two Weeks Notice," "Urban Legend").
"The excitement is palpable as these talented writers, composers and actors work against the clock to bring their musicals from their imaginations to the stage in record time," said Shelly Maxwell, executive vice president of NCM Fathom Events, via press release. "Fans of live theatre will find this one-of-a-kind Fathom Event truly captivating."


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Update: Our winners are Wendy, Brian and Shannon (I got two extra adult tickets in my envelope).
For today's giveaway, I have two sets of tickets — one adult and two children per set — to the Northeast Family Chocolate Festival, scheduled for 10 a.m. to 4 p.m. Saturday, April 9, at the Washington Avenue Armory. There will be an abundance of chocolate, food vendors, live music, live magic, a dessert-making demo and family fun. Details here. Regular admission is $8 adults, $5 kids age 2 to 12.
As you know, we have rules here for our giveaways, and they go something like this:
- If you won in the last 90 days, you cannot win again.
- If you failed to pick up a prize, you are ineligible for one-year from date of the giveaway you won.
- Everyone can only answer once. Answering more than once will mean both answers are disqualified.
- The winner is chosen at random and all applicable answers stand an equal chance.
- If you don't answer the question, you aren't eligible to win (a lot of you ended up in this boat in the past).
- The contest closes at 5 p.m.
- Make sure your correct e-mail is included in the box that says "e-mail" when you submit your comment. That is how we notify winners.
- Unless another arrangement is made, prizes are to be picked up at the main Times Union building in Colonie during our business hours (8 a.m. to 5 p.m.) within a week of winning, or we will pick a new winner.
The question: Some people call themselves a chocoholic. What would be your -aholic, and why?


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Narrows League cross country coaches are producing weekly updates this season. Here's the first installment:
7 September 2011
Bellarmine Invite
The pre-season No. 1-ranked Bellarmine Lion girls face off with the defending state champions and second-ranked Eisenhower Cadets Saturday at the 13th Annual Bellarmine Invite. The varsity girls race at 11:40 am. Top individuals to watch: Mayra Chavez, Eisenhower; Daryl Phill, Bellarmine Prep, Lily Engelbrekt, Bishop Blanchet, and Jordan McPhee, Mt. Rainier
On the boys' side, No. 11 Bellarmine, led by Ian Staeheli, No. 13 Puyallup, led by Brett Bertrand, and Central Kitsap, led by Michael Thorsen, will try to close the gap on No. 1-ranked Eisenhower, who is led by Santos Vargas.
Capital Invite
The No. 2 ranked Gig Harbor Tides boys will race at the Capital Invite, which is shaping up to be a showdown with No. 6 Auburn Riverside and No. 10 Jackson. The individual race should be full of early season fireworks with Gig Harbor's Will Drinkwater taking on Korey Krotzer of Auburn Riverside and Blake Nelson of Jackson in the senior boys' race.
The Stadium, Olympia, Gig Harbor, Shelton, Lincoln and Timberline will be racing on the girls' side in an early season battle for Narrows League No. 2.
In other news, South Kitsap will begin its season at the Tahoma Relays. Foss, Mt. Tahoma, Wilson, and Yelm will not be in action this weekend.


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Spring Egg Hunt
Children in preschool through third grade can bring a basket and gather eggs and candy at Watts Park. Bring a camera for pictures with the spring bunny. glencoeparkdistrict.com
Bring a basket to Clarkson Park and get ready to fill it with plastic eggs and prizes. The hunt is broken down by age group with a winner in each category. Other highlights include pictures with the bunny and face painting. northfieldparkdistrict.org
Linden Square Bunny Hop
Bring the family out to Linden Square to celebrate spring. The event includes hunting for surprises and hopping after the bunny who visits all of the participating businesses. There are pictures with the bunny, and a chance to meet local firefighters and extras like face painting and balloons. Free. wilmettechamber.org
Egg Hunt
Bring your own basket and get ready to fill it with fun. Children ages 3 to 8 can hunt for goody-filled eggs at West Elm Park. In case of rain the hunt is moved indoors. winpark.org
Children's Day
Hosted by Fleetwood-Jourdain Community Center, this day is dedicated to children. Events include face painting, food, games and entertainment. Free. cityofevanston.org
Springtime on the Farm
Spring is a busy time on a farm full of new beginnings. Visit friendly livestock, make a spring craft, work the fields with the farmers, and experience spring-cleaning farm chores as well as snacks and beverages. wagnerfarm.org
11 a.m.-7 p.m.
Skokie Festival of Cultures
Travel the world right in your own backyard. This annual fest celebrates Skokie's diversity with music, dance, food, crafts, children's games and more from a variety of world cultures. There are also cultural booths and displays. skokieculturefest.org


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As a family travels to a cancer clinic in Mexico, son Theo has been having strange dreams. And, as they're passing through Arizona, "the walls between worlds dissolve and Theo is kidnapped by the vampire prince Thorn".
There are no reviews for this title yet.
In the sequel to Riverrun, young Theo Etchison is drawn into Strang's terrifying dimension and begins a bizarre odyssey across an inverted land.
Follow the exploits of the Etchison family as their mortal world is rehaped by warring dragon-children under the control of the Darkling King Strang. Within Theo Etchison lies the power of a Turthsayer, a power the Darklings need to dominate the universe.


text: [ On Thursday, January 24, 2002 at 08:41:35 (+0100), firstname.lastname@example.com wrote: ] > Subject: Re: TTY virtualization driver > > > I personally think there's more benefit to doing this kind of name > > mapping in ttys, network interfaces (at least per physical layer type), > > THIS WOULD BE REAL MESS! On the contrary. It would be a joyful and elegant state of uniformity. > it would be almost linux. You really must learn to judge ideas just by their basic merits, not by botched implementations of them. > for me it's easier "i connected to my second cyclades card port 17, so i > need to use /dev/ttyZ1017" The world of systems supported by NetBSD is much wider and more varied than your view of it seems to be. -- Greg A. Woods +1 416 218-0098; <email@example.com>; <firstname.lastname@example.com>; <email@example.com> Planix, Inc. <email@example.com>; VE3TCP; Secrets of the Weird <email@example.com>


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Call To Book
Welcome to the TownePlace Suites Denver Tech Center hotel! A home away from home, our extended stay suites include full kitchens with ovens and a living space. Start your morning off right with our free breakfast buffet. Our hotel in Englewood, CO is conveniently located close to Park Meadows Mall, Fiddlers Green and IKEA. Want to explore the Denver area? Our Denver Tech Center hotel is just blocks from RTD Light Rail direct to downtown and in close proximity to many top Denver businesses. With such a convenient location & apartment-style accommodations, this extended stay hotel is ideal for corporate housing, family vacations, relocations & business travel. Take advantage of our high-speed Wi-Fi, full-service business center, fitness center and outdoor pool. Whether youre here for a business meeting or for a relaxing Colorado vacation, enjoy a comfortable stay at one of the top hotels in Englewood. Stay fit while you're traveling, take advantage of our partnership with Colorado Athletic Club.
USD 25 non-refundable cleaning fee Per Night; maximum of 2 pets allowed


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Re: Welcome aboard fella
by Big D
Thanks. I look forward to many more hikes with him. Hey, I need the exercise.
Posted on Aug 18, 2012, 2:41 PM
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At least, that's what I get out of it. It's like a thinner, less rich, more synthetic take on Tonka Imperiale. While not a perfect replacement, I've never smelled something closer to Tonka Imperiale.
Whattya think?
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At least, that's what I get out of it. It's like a thinner, less rich, more synthetic take on Tonka Imperiale. While not a perfect replacement, I've never smelled something closer to Tonka Imperiale.
Whattya think?
Never tried the Guerlain, but i find EdB outstanding, and with some similarities with Tobacco Vanille.
Agree that it is a very good scent.
I find the Guerlain to be sweeter, more refined, a touch floral, just overall a little more "feminine", while EdB is denser, thicker maybe a little corniferous?
I find them to be distinctively different :)
We need to bring Puddle Monkey in on this . . . . he's becoming world renowned for associations between different frags
Ps: Nothing poor at Eau des Baux
I like Eau des Baux more than Tonka Imperiale.
I don´t know TI but I love EDB!
Eau des Baux is a quality fragrance with a fair price. Lightly sweet and elegant.
Count me in as an Eau des Baux fan. Some similarities to Tonka Imperiale, though, like timaru, I find TI to be a bit sweeter and leaning a little towards the feminine side of unisex. Eau des Baux is a little more broody and heavy. I like both equally.
Great price point on Eau des Baux.
Not familiar with Tonka Imperial, but for the price point EdB is a bargain and quality juice. Especially when L'Occitane has 20% off sales...
Trying them left / right and I can see where you're coming from - especially an hour and half in.
"Eau des Baux - A poor man's Tonka Imperiale" - hardly the most flattering of comments......
Obviously, Eau des Baux is well respected and is much more fairly priced.
Perhaps Tonka Imperiale should be described as "An Idiot's Alternative".... ?? ....
I don't mean to offend any TI lovers out there..... just take this as a tongue in cheek comment.
Maybe more now than before. I'm not a person that calls reformulation on most thing, but EdB has definitely changed, and to my nose for the worse. It used to be greener, and borderline sweet. Now it has went way past that border. Unusably sweet for me :(
After seeing EDB almost unanimously defeat Burberry London in a "What should I get?" poll earlier this week, I'm becoming very interested in it. Never heard of it until this Monday.
eh, unless I'm missing something, I wouldn't really compare these two... I find the EdB has a sort of raspy dryness in the opening, and the T.I. has a cherry liquor accord, so those two aspects don't compare at all.
I don't know what formulation I have - it's a sample I got in a swap awhile back. I'm not saying it's a dead-ringer for Tonka Imperiale, but there's a strong tonka presence in my Eau des Baux, and that, mixed with a coniferous element, draws a lot of parallels to TI with its rosemary and tonka. I get a noticeable dose of IES in the drydown of EdB though, and it definitely is thinner and more masculine than TI.
I just think that fans of one would probably be fans of the other.
I love them both, but one doesn't remind me much of the other.
Any thoughts on the reformulation? Was going to pick some up but if it's changed...


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Local teams advance to rocketry finals
Published 4:20 pm, Wednesday, April 3, 2013
Three San Antonio teams advanced to the finals in the Team America Rocketry Challenge, which bills itself as the world's biggest student rocket contest.
"Team Immortal" and "The Ninja Turtles," both from the Krueger School of Applied Technologies and "Team Eclipse" from the Engineering and Technologies Academy qualified for the event, to be held May 11 in Washington.
All three teams are from the North East Independent School District.
A total of 725 teams vied for a spot in the finals; the top 100 advanced.


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Product Features
*Available for US Shipment Only.
Oversized your field of view without compromising fit.
Key Features of Oakley Canopy Goggles:
- Large lens design expands peripheral view in every direction
- Oakley''s patented O-Flow Arch allows for easy breathing and unrestricted airflow
- Streamlined frame design provides full helmet compatibility
- Discreet frame notches at temples provide compatibility with most prescription eyewear, without compromising fit
- Dual-vented lenses with F3 anti-fog coating
- Large Fit
All Gear by: Oakley


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June 20, 1998
Jesse James, Chanel
Two and a half years old
Male, Female
Miniature Pinschers
Coquitlam, British Columbia, Canada
ere are a couple of Miniature Pinschers. They are very hyper but some of the best dogs I have ever known - smart, energetic and willing to please all the time. The left one standing is a male. He is 2.5 years old and his name his Jesse James. We call him that because he is a menace and likes to get into trouble. He yaps a lot and pretends to be the dominant one until someone or some dog comes after him, then he runs for me. Jesse is easy to train. He rolls over, sits, stays, heals and comes when you call him.
Chanel is a female and a little bigger than Jesse. She is quiet and will stand up to any thing or dog. Very brave. She loves to play with big dogs. She has her own mind and won't come the first time you call her. She plays stubborn. She is affectionate when she wants to be. Jesse and Chanel were supposed to be mates but we had them fixed. Now they both share in each others lives and love playing and cuddling with each other. They are very protective of each other, Jesse more so toward Chanel.
If you want a big dog in a small body, these are the dogs to get. Chanel weighs 14lbs. and Jesse is 8.5 lbs. They both stand around 12" high. We didn't crop the ears but the tail is cropped. Very clean dogs. They always get the "double-take looks" when we walk them.
Find out how
your pet
could be Pet of the Day.


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Prevent Cancer by Banning Bacon and Nixing Nicotine
The American Cancer Society's annual Great American Smokeout takes place this week, shifting the public's focus toward cancer prevention. Cigarettes are an easy target, since their link to cancer is well-publicized, and the vast majority of smokers already want to quit. But despite the drop in smoking, cancer rates are still high. So we need to go several steps further. The next culprits are processed meat products, such as bacon, hot dogs, and deli meats. Just as tobacco attacks the lungs, processed meats attack the digestive tract. The World Cancer Research Fund says the link between processed meat and cancer is so strong that it should be avoided completely. The EPIC study results published earlier this year show that eating processed meat is linked with a 44 percent increased risk of death. A recent study from the Journal of Clinical Oncology found that colorectal cancer survivors who consume large amounts of processed meat are at a 29 percent higher risk of death from general causes and a 63 percent higher risk of death from heart disease. While tobacco products have been the object of labeling efforts designed to maximize risk awareness, processed meat products have gone under the radar. Mayor Bloomberg just signed new legislation raising the legal purchasing age of cigarettes from 18 to 21. If he and other politicians truly have their constituents' health in mind, they will make the same efforts to label and restrict the purchase of hot dogs and other processed meat products. But consumers certainly don't have to hold out for a new law to can the cigarettes, scrap the bacon, or share a healthful recipe with some friends. Positive change can happen anytime—so start now and help lead the cultural shift towards better health.
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You play a dangerous game doing a Hitler parody. There is no link to the video - this is safe for work.
Jefferies Group wrongfully fired its former Asia head of equity trading Grant Williams over a newsletter that included a reference to a Hitler parody video, a Hong Kong judge ruled.
Bloomberg reports that Williams drafted a newsletter to subscribers which included a link to a video clip depicting Adolf Hitler, with subtitles created by a U.S. filmmaker that mocked JPMorgan Chase Chairman and CEO Jamie Dimon.
The newsletter was released prematurely and Jefferies fired Williams the next day for unacceptable and inappropriate conduct, according to the judge.
Jefferies management was 'hypersensitive' and 'irrational', in its response to the publication of the December 7th, 2010 client newsletter, Judge Conrad Seagroatt said in issuing his decision Thursday in Hong Kong's High Court.
Williams is seeking damages of at least $1.7m for wrongful dismissal and Jefferies' breach of trust and confidence, his lawyer Kevin Bowers said. Seagroatt said he would issue written reasons for his decision and rule on the damages later.
The YouTube Inc. parody video clip uses a scene from the 2004 German movie Downfall showing Hitler screaming at his subordinates at the end of the war. Subtitles suggested Hitler's character was Dimon, speaking in the context of bets on the price of silver.
'Jefferies was seen as a company associated with that video that insulted in a quite humiliating way a competitor and business partner', Jose Maurellet, a lawyer for the firm, told the court.
Williams had submitted a draft of the newsletter for approval to his London-based supervisor as required, his lawyer told the court in his closing statement. The newsletter was sent out from New York before being approved and without Williams's knowledge, said Ashley Burns, another lawyer representing Williams.
Hit the link below to access the complete Bloomberg article:
Jefferies Wrongfully Fired Asia Trader Over Hitler Video
Credit Suisse, Baer Seen Facing Delay in U.S. Tax Deal
Five Banks Must Raise $21 Billion in Fresh Capital
image: © Steve Jurvetson


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Public Rights: 1950-1985
Rationing public space and keeping subservient groups separate from dominant groups is one tactic for maintaining power in society. When a dominant group controls space, it can prevent members of subservient groups from banding together and it can insulate members of the dominant group from outside influences and ideas. Battles over the occupation of public space are, therefore, common in civil rights movements. In the early history of this country, as industrialization created more market jobs for men outside the home, women were relegated to the private sphere of home and family. Women who broke with tradition and claimed public space were shunned or, like Anne Hutchinson, condemned as heathen. Women entered the public sphere to protest slavery and later to demonstrate against drinking beer and whiskey. Some women even entered taverns and bars, places that were typically off-limits to women and where their mere presence challenged male customers and changed the political discourse over alcohol use. Other public arenas that were closed to women included wage-paying jobs, seats of government, voting booths, and juries. Feminist legal strategies and legal arguments challenged these exclusionary practices. But before the legal challenges occurred, feminist political action brought women together in spaces where they could meet safely. In the 1800s, those spaces were likely to be churches and schools. In the 1970s, women met in consciousness-raising sessions in private homes. Ultimately, women in both the first and second waves of feminism entered the public streets to demonstrate their solidarity and to announce that they would no longer be confined to the private sphere.