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HIV JournalView
August 2004
Table of Contents
An Alternative for Peripheral Neuropathy
Hart AM, Wilson ADH, Montovani C, et al. Acetyl-l-carnitine: a pathogenesis based treatment for HIV-associated antiretroviral toxic neuropathy. AIDS. July 23, 2004;18(11):1549-1560.
It is difficult to imagine: pain with every step, lying awake in bed, feet on fire, a tingling numbness that doesn't allow you to think of anything else. Painful distal peripheral neuropathy (PN) is a particularly insidious adverse effect of certain HIV therapies, and a common complaint in clinical practice.
To a great extent, the incidence of antiretroviral-related PN has been pegged to the popularity of the deoxynucleotide analogue agents -- stavudine (d4T, Zerit), didanosine (ddI, Videx) and zalcitabine (ddC, Hivid); as use of these agents has waned, so too has the incidence of drug-associated PN. However, for various reasons, some patients still require these antiretrovirals. Therapy for painful PN has had limited success and there are no licensed effective therapies to date. Once the cornerstone of therapy, tricyclic antidepressants have given way to anticonvulsants such as gabapentin (Neurontin) and lamotrigine (Lamictal). Yet, for many PN sufferers, these agents -- even in combination with narcotic analgesics -- provide less than complete relief and add additional pill burden to standard HIV regimens. Withdrawal of the offending antiretroviral is often possible, although, in some cases, there is the risk of loss of control of HIV viremia. Further, the heavy reliance on stavudine in the developing world insures that PN may become a major issue in the management of HIV in these areas. Therefore, an effective therapy for relief of antiretroviral-associated PN remains an important priority.
The etiology of treatment-associated PN is thought to be rooted in the mitochondrial toxicity of certain antiretrovirals. With a drug-mediated reduction in neuronal mitochondrial DNA, disruption of oxidative metabolism within these organelles ensues. Neurons, with their long axons, become unable to meet the demands of their unique metabolism and eventually wither. Biopsies of epidermis confirm that patients with PN have fewer peripheral nerves than those without PN. This putative mitochondrial toxicity mechanism has sparked investigations into therapeutic approaches that aim to protect mitochondrial function.
Acetyl-L-carnitine (ALCAR) is an integral transport molecule for free fatty acids as well as an acetyl-group donor in high-energy metabolism and free fatty acid beta-oxidation within mitochondria. In addition, ALCAR has been shown to promote nerve regeneration and to be neuroprotective in patients with diabetes, preventing development of PN and reducing pain scores in those with the sensory neuropathy. Less is known about the effect of ALCAR in antiretroviral-associated PN.
To assess the efficacy of ALCAR, researchers in the United Kingdom administered the drug orally at 1500 mg twice a day for up to 33 months in 21 patients who had established antiretroviral-associated PN and were not on other PN therapies. In addition, 5 HIV-uninfected individuals who did not have PN were recruited as controls. Nerve biopsies were performed in both subjects and controls. The subjects were fairly antiretroviral experienced and had a median exposure to 6 antiretrovirals in the past. The median viral load was <400 copies/mL and the median CD4+ cell count was 286 cells/mm3. All had grade 1 or higher PN and most required some form of analgesic, although only 3 subjects were taking narcotics. The median duration of PN was 11 months.
Among the 21 subjects, 15, including 2 of the 3 subjects who had grade 3 PN at entry, had improvement in their neuropathy by standard adverse event grading score. More detailed pain or quality of life scores were not reported. One subject had worsening of PN on treatment; 3 subjects switched from stavudine or didanosine to an alternative antiretroviral during the study. Whether these subjects were responders was not described. Those who stopped ALCAR had worsening of symptoms in this open-label study. Apparently, ALCAR was well tolerated.
Biopsies of the skin from the most effected leg were performed at baseline in all subjects and in the 5 controls. Eleven subjects had a follow-up biopsy. The controls had normal cutaneous innervation patterns. The subjects with PN had almost complete absence of nerve fibers in the epidermis, subepidermal plexus and around the sweat glands. The use of ALCAR by those with repeat biopsies at 6 months led to marked normalization of the innervation of these structures. Quantification of fiber types was accomplished by immunostaining and dramatic increases in small sensory fibers in particular were found.
This study provides initial evidence for the efficacy of ALCAR for antiretroviral-associated PN. The biopsy results are striking and bolster the clinical improvements observed. These exciting findings certainly support larger clinical investigation of this agent and offer renewed hope for people who are suffering from antiretroviral-associated PN. The results also suggest that this may be a potential, and maybe cheap, therapy for other mitochondrial toxicity disorders and this too requires further study.
Stable Viral Load but Evolving Drug Resistance
Kantor R, Shafer RW, Follansbee S, et al. Evolution of resistance to drugs in HIV-1-infected patients failing antiretroviral therapy. AIDS. July 23, 2004;18(11)1503-1511.
While the major goal of antiretroviral therapy (ART) is to drive plasma HIV levels to below the lower limit of an ultrasensitive assay, in real life many, if not most, patients have detectable viremia while on HIV therapy. For instance, a common clinical scenario is the patient on potent ART who has had a 2 or more log10 decline in plasma HIV RNA and has sustained CD4+ cell count increases but continues to have low-level, detectable viremia. For many clinicians, this has been the equivalent of an Olympic silver medal -- it's not gold, but it's close. However, emerging data suggest that some patients with stable, low-level viremia do accumulate new ART resistance.
To evaluate the risk of resistance cultivation in patients with viremia, researchers at Stanford University in California searched their database for patients with known treatment histories, 2 genotypic resistance tests performed at least 2 months apart and no change in ART during the period between the 2 genotypic resistance tests. Their search yielded 106 patients.
They found that the median duration of the ART regimen prior to the patients' first genotypic resistance test was 29 months. The median time between genotypic resistance tests was 14 months. Patients had a median exposure to 6 drugs at the time of the first genotypic resistance test and almost 73% of the patients were protease inhibitor (PI) experienced. There was little, if any, ritonavir (RTV, Norvir)-boosted PI use.
For the first genotypic resistance test, the median viral load and CD4+ cell count were 3.7 log10 cpm and 336 cells/mm3, respectively. At the time of the second genotypic resistance test, these were 4.0 log10 cpm and 339 cells/mm3, respectively, which was statistically significant only for the change in viral load.
In the period of time between the 2 genotypic resistance tests, 75% of the patients had developed a new drug resistance mutation. There were PI mutations in 62% of those on PIs, nucleotide reverse transcriptase inhibitor (NRTI) mutations in 42% of those on drugs of this class and non-nucleotide reverse transcriptase inhibitor (NNRTI) mutations in 29% of those on efavirenz (EFV, Sustiva, Stocrin) or nevirapine (NVP, Viramune).
Among patients with a viral load of less than 5000 cpm at first test, 37% developed new drug resistance, as did 12 of the 13 patients who maintained a viral load of 50-999 cpm. Conversely, 21% of the patients "lost" resistance mutations from the first to the second genotypic resistance test (i.e., these mutations were no longer detected, although they were almost certainly still present). The total number of drugs predicted by resistance testing to be "resistant" increased from a median of 8 to 10.
Interestingly, there was no major difference in the acquisition of new resistance mutations between patients who experienced virologic and/or immunologic improvement in between assays and those who did not. Not surprisingly, patients who had fewer resistance mutations at the time of their first genotypic test were more likely to develop new mutations -- probably because those with lots of resistance at baseline already developed their resistance mutations. Further, longer time between assays was associated with an increased risk of resistance.
These results are cause for concern. While, reassuringly, CD4+ cell counts and viral loads changed little while ART was continued and viremia remained detectable, drug resistance increased in the great majority of patients nonetheless. Similar results were presented at the International AIDS Conference in Bangkok.1
Clinicians confronted with a patient who has reduced but persistently detectable viremia must balance these findings with other factors. This includes a consideration of available treatment options as well as patient willingness to change therapy that, by clinical criteria are successful, as evidenced by rising CD4+ cell count and reduced viral load. Chasing viral load to undetectable is not without its own risks (i.e., toxicity, poor adherence) and whether in this case the enemy of "good enough" is "even better" needs to be considered and certainly studied prospectively. I must admit I am now eyeing my persistently viremic, ART-receiving patients less sanguinely than before and have begun to intensify therapy when possible.
Niacin Revisited
Gerber MT, Mondy KE, Yarasheski KE, et al. Niacin in HIV-infected individuals with hyperlipidemia receiving potent antiretroviral therapy. Clin Infect Dis. August 1, 2004;39(3)419-425.
Niacin (Niacor, Niaspan) is an effective lipid-lowering therapy in HIV-uninfected patients that, like statins, can lower low-density lipoprotein (LDL) cholesterol but can also raise high-density lipoprotein (HDL) cholesterol and reduce triglycerides. The use of traditional niacin has been limited by its toxicities, which include cutaneous flushing and insulin resistance. Extended-release niacin (niacin ER) has been associated with lower rates of flushing and improved hepatic safety. However, use of this agent in the setting of HIV-associated dyslipidemias has been cautious, as there remains the potential for hyperglycemia with niacin ER.
In this pilot study, Gerber and colleagues at Washington University administered 2000 mg of niacin ER to 14 patients receiving highly active antiretroviral therapy (HAART) -- PI or NNRTI based -- who had fasting triglyceride levels >200 mg/dL and/or direct LDL cholesterol >130 mg/dL. All subjects were to follow a National Cholesterol Education Program (NCEP) Step I diet that began 4 weeks prior to niacin ER administration. Simultaneously, all lipid-lowering agents were discontinued.
Niacin ER was started at a dose of 500 mg daily, increased to 1000 mg at week 2 and titrated by 500-mg increments every 4 weeks up to 2000 mg daily, with the aim of driving triglyceride levels below 200 mg/dL or to the NCEP goal for LDL cholesterol. Aspirin was recommended 30 minutes before niacin ER dosing as a prophylaxis against flushing. Niacin ER was stopped after 14 weeks. Numerous evaluations were conducted during the study, such as lipid profiles that included direct LDL cholesterol measurements and 5-hour, 11-point oral glucose tolerance testing.
The 14 subjects were all male and, save for one, all white. The median age was 48.9 years and the median baseline CD4+ cell count was 421 cells/mm3. Only 4 subjects were taking statin therapy at baseline (2 of whom were also on a statin). The efficacy results of the study are presented below. Recall that study entry is 4 weeks prior to administration of niacin ER and is when the NCEP diet commences. Median values are presented.
Of the 14 subjects enrolled, 12 completed the study. The 2 patients who did not complete the study were both hospitalized -- one for exacerbation of preexisting heart failure and the other for pneumonia. Six (43%) of the subjects reported adverse effects from therapy, mostly flushing, itching or headache -- none of which led to treatment discontinuation and, generally, the symptoms improved during the course of the study. There were no significant changes in hepatic transaminases, uric acid, CD4+ cell count or HIV viral load.
Eleven subjects underwent an oral glucose tolerance test (OGTT). Incredibly, 6 of the 11 subjects were found to be glucose intolerant (2-hour OGTT value >140 mg/dL) at the start of treatment with niacin ER. After 14 weeks of niacin ER, 3 additional subjects met the criterion for glucose intolerance while 2 subjects with glucose intolerance at the start of therapy had 2-hour levels below 140 mg/dL (113 mg/dL and 136 mg/dL) at the end of treatment. Based on the homeostasis model of insulin resistance (HOMA-IR), insulin sensitivity was found to be significantly reduced after niacin ER therapy. No subject developed frank diabetes.
Niacin ER, given its lack of drug-ART interaction and effect on HDL cholesterol and triglycerides, is an attractive therapy for HIV-associated dyslipidemia. The risk of developing or exacerbating glucose intolerance limits the attractiveness of this agent in this setting. This pilot investigation suggests that niacin ER may be better tolerated than suspected, but that caution regarding its use in those with glucose intolerance is justified. Overall, there was an increase in insulin secretion secondary to heightened beta cell sensitivity to stable glucose levels, but this insulin resistance did not lead to overt diabetes. However, keep in mind that this was a small study of relatively short duration and the maximal dose of niacin ER was not achieved until shortly before the study ended.
Further, these results can hardly be categorized as blockbuster. Since it is a small cohort, one cannot read too much into the magnitude of response seen; however, the absence of significant reductions in LDL and HDL cholesterol levels tempers enthusiasm for an agent that is designed to do just that -- especially since statins are being used with some measure of success in HIV-infected persons. But evaluation of alternatives is warranted because there are patients already receiving or who can not tolerate a statin who may benefit from niacin. For these patients, these data assuage some of the concerns regarding toxicity and provide a green light for bigger and better studies of the efficacy of extended-release niacin in HAART-treated patients.
HIV on Campus
Centers for Disease Control and Prevention. HIV transmission among black college student and non-student men who have sex with men -- North Carolina, 2003. MMWR. August 20, 2004;53(32)731-734.
The role of men who have sex with men (MSM) and also have sex with women in the spread of HIV has received considerable attention of late. A cover story in The New York Times Magazine, an "Oprah" show dedicated to the topic and segments on the nightly news programs have introduced the term "living on the down low" to the HIV/AIDS lexicon.
The focus of attention has been concentrated on those African-American men who, although they have sex with both men and women, consider themselves straight. In urban areas where HIV infection is prevalent, there is a 14% incidence and 32% prevalence of HIV among young, African-American MSM. Further, the dramatic increase in the proportion of African-American women in the United States who acquire HIV via heterosexual contact has led to renewed examination of the intimate behaviors of the men from whom they acquired the virus.
In North Carolina, a program designed to identify acute HIV infection among those presenting for HIV antibody testing, in November 2002 identified 2 male, African-American college students with acute HIV. A retrospective review of all men between 18 to 30 years of age with HIV diagnosed during January 2000 to May 2003 indicated an increase in HIV case reports among male college students, from 2 cases in 2000 to 56 cases during January 2001 to May 2003. Of these 56, a total of 49 of the cases (88%) were African-American, and nearly all were MSM, including some men who had sex with both men and women.2
In follow-up, a case control study was initiated to identify behavioral risk factors for HIV infection in young, black MSM. Cases were black, HIV-infected, MSM college students, age 18 to 30 years, diagnosed during 2001 to 2003. All were North Carolina residents. These cases were compared to 2 groups of HIV-uninfected controls: college students and non-students, all of whom also were also black MSM, aged 18 to 30 years, who lived in North Carolina.
Face-to-face interviews were conducted to obtain epidemiological and behavioral information, data on sexual behaviors during the year prior to HIV diagnosis for the HIV-infected college students or the date of interview for HIV-uninfected college students and non-students. In addition, according to the report, 3 discussion groups were held during which approximately 60 black male and female students from 11 colleges in North Carolina discussed perceived barriers to sexual risk reduction and suggestions for prevention programs targeting college students.
Importantly, during the study, the overall rates of newly reported HIV infection in North Carolina were higher in black men in all age groups compared with white men overall (see Figure). The increase in HIV infection among black men aged 18 to 24 years increased significantly from 65 per 100,000 population in 1998 to 92 per 100,000 population in 2002 (P<.01).
The study recruited 17 (35%) of the 49 African-American men who were college students and identified by the state surveillance system as being HIV infected. The 2 groups of HIV-uninfected controls: 19 HIV-uninfected college students and 15 HIV-uninfected non-students were recruited during HIV pre- or post-test counseling activities at local health departments (n = 5), gay nightclubs (n = 26) and the North Carolina Pride Festival (n = 3).
The general characteristics of the 3 groups (HIV-infected MSM college students, HIV-uninfected MSM college students and HIV-uninfected MSM non-college students) were similar; however, there were higher rates of sexually transmitted diseases among the HIV-uninfected students compared to the HIV-infected group. College students, not surprisingly, were younger than non-students, and the mean number of lifetime sex partners was lower for college students (mean no. of partners was 20 for HIV-infected students and was 18 for HIV-uninfected students) than for non-students (mean no. = 13). The mean number of steady male partners during the preceding 12 months was similar for the 3 groups and the frequency of unprotected receptive anal intercourse with steady partners ranged from 38% among non-students to 56% among HIV-infected students. More non-students tended to have casual male sex partners than students. Approximately 20% of all the study participants had a female sex partner during the preceding 12 months and this did not differ between the groups. While one third of both HIV-infected and HIV-uninfected college students met sex partners on college campuses, most met their sex partners at gay nightclubs or over the Internet. Compared to non-college students, fewer college students identified themselves as gay or disclosed their sexual identity.
This report identifies several concerns. First, surprisingly, despite high-risk behaviors and high rates of prior sexually transmitted disease, HIV-infected African-American college students in this study did not perceive themselves to be at risk for HIV infection prior to their diagnosis. Second, these men did not always identify themselves as gay and a substantial proportion had sex, often unprotected, with women. Therefore, these men may be transmitting HIV to female partners.
In addition, prevention messages aimed at MSM may not be effective at reaching these men as they do not always identify as MSM. Lastly, while much attention is paid to the spread of HIV in urban settings, this study suggests that the epidemic has become well entrenched in the more rural South. As a transplanted Northerner treating HIV in North Carolina, this author can attest to the need for additional resources to develop an improved understanding of HIV transmission in the southern United States and, ultimately, effective prevention interventions for our at risk populations.
This article was provided by TheBodyPRO. It is a part of the publication HIV JournalView.


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Even in an age of superlatives, the British Museum has something special -- the oldest known figurative art in the world.
The artworks on display in the new exhibition "Ice Age Art" are so old that many are carved from the tusks of woolly mammoths.
But it's not just their age that may surprise visitors. It's their artistry.
These are artworks, not just prehistoric artifacts. Some of the sophisticated carvings, sculptures and drawings of people and animals look like something Pablo Picasso or Henry Moore might have created.
That shock of recognition is the aim of the show, which is subtitled "arrival of the modern mind" and explores the moment the human brain began to embrace abstraction, symbolism and imagination.
We don't know what these distant ancestors believed or how they communicated, but we know how they thought -- like us.
"They are fully modern humans," Jill Cook, the museum's curator of Paleolithic exhibitions, said Tuesday. "What these works of art show is that they have a visual brain capable of imagination and creativity.
"They really are us. They are our ancestors."
Although early humans were making sophisticated tools, abstract items and music in southern Africa 100,000 years ago, the earliest surviving works representing people and animals appear after groups of people moved into eastern and central Europe some 45,000 years ago.
The plentiful wildlife roaming the grassy plains helped these communities of hunter-gatherers grow and flourish.
"The living was quite easy," Cook said.

subset: commoncrawl


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Srixon Qualifier Series
Tedesco Country Club
Marblehead, Mass. • July 22, 2007
STOW, Mass. -Michael Cheng of Woodbury, N.Y., carded a 3-under-par 69 to medal in the Boys Division of the Fidelity Investments Junior Classic Srixon Qualifier Sunday. Harin Lee of Bayside, N.Y., recorded a 3-over-par 75 to medal in the Girls Division.
Conducted by the American Junior Golf Association, the Fidelity Investments Junior Classic Srixon Qualifier was an 18-hole stroke play event held at Stow Acres Country Club — South Course. The 100-player field featured players from 12 states and Mexico. The course was played at 6,440 yards for the Boys Division and 5,785 yards for the Girls Division.
Cheng said he used his strong putting to save pars and make birdies.
"My two birdies in a row kept me motivated," Cheng said. "It helped me to keep going."
With birdies on Nos. 5, 8, 12, 13 and 18 Cheng finished with a 1-under-par 35 on the front nine and a 2-under-par 34 on the back nine.
Ten additional boys qualified for the tournament. Jeff Hatten of Farmington, Conn., fired a 2-under-par 70. Joshua Briere of Newport, Vt., and Adam Vaccari of Winsted, Conn., posted even-par 72s. Parker Bova of Avon, Conn., and Spencer Bova of Avon, Conn., recorded 1-over-par 73s. Bryan Otis of Yarmouth, Maine, and Michael McCarthy of Tolland, Conn., finished with 2-over-par 74s. Qualifying after a sudden-death playoff were Manny Tulumaris of Burlington, Conn., Robert Jorgensen of New Hartford, N.Y., and Doug Kleeschulte of Kingston, N.Y., carding 3-over-par 75s.
Qualifying but opting to take a Tournament Exemption in lieu of playing in this week's event were Nick Harris of Marlborough, Mass., posting an even-par 72, Kyle Sargis of Lexington, Mass., shooting a 1-over-par 73 and Brendan Meagher of Weston, Mass., recording a 2-over-par 74.
In the Girls Division, Lee said her chip in on No. 3 for birdie helped her feel confident about her round.
"My parents were cheering really loud for me," Lee said. "That gets me excited for the next hole."
Also qualifying for the tournament were Brooke Stepanek of Guilford, Conn., posting a 5-over-par 77, Eunae Jo of Ridgewood, N.J., carding a 6-over-par 78 and Alice Choi of Whitestone, N.Y., recording an 8-over-par 80.
Qualifying but opting to take a Tournament Exemption in lieu of playing in this week's event was Lynda Kwon of North Wales, Pa., finishing with a 7-over-par 79.
SRIXON Sports USA, Inc., based in Lawrenceville, Ga., has been distributing premium golf balls and equipment in the U.S. since 1997 and is a subsidiary of SRI Sports Limited. SRI Sports Limited is the number one golf club manufacturer in the world's second largest market, Japan, and is one of the world's leading patent holders in golf ball technology. SRIXON golf balls earned 26 tournament victories on multiple professional tours around the world in 2006.
AJGA alumni have risen to the top of amateur, collegiate and professional golf. More than 160 former AJGA juniors currently play on the PGA and LPGA Tours and have compiled more than 300 wins. AJGA alumni include Tiger Woods, Phil Mickelson, Jim Furyk, Stewart Cink, Davis Love III, Cristie Kerr, Pat Hurst, Paula Creamer, Brittany Lincicome, Morgan Pressel and Julieta Granada.
First-round tee times for the Fidelity Investments Junior Classic will run from 7-8:57 a.m. off the Nos. 1 and 10 tees at Tedesco Country Club. For more information about the tournament, please contact tournament headquarters at (781) 631-8263.


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Free Legal Resources, Pennsylvania - 2014 Update
May 28, 2014
By Ed Greenlee, Associate Director of Public Services
If you are seeking to perform Pennsylvania legal research, a variety of free legal web-based Pennsylvania resources are available. While these sites do not replace Lexis Advance, WestlawNext, or Bloomberg Law, they are great starting points to begin your research. This post collects a sampling of some free Pennsylvania primary sources covering case law, statutes, bills, administrative codes and regulations, and the constitution.
To access information about Pennsylvania Courts visit the Unified Judicial System of Pennsylvania, this site contains appellate court opinions, statewide dockets, annual statistical reports and more. You will find information on the Pennsylvania Supreme Court, Superior Court, Commonwealth Court, Common Pleas Courts and minor courts. There is information dates back to 1996 for the Supreme Court and 1997 for Superior and Commonwealth Courts.
PA Statutes and Bills
You can access Pennsylvania's statues via the Pennsylvania General Assembly's webpage, which allows browsing by title. Statutory text is available in PDF, Word, and html formats. It also links to the Pennsylvania Senate and House as well. State bills are also searchable via the General Assembly webpage, by bill number, keyword, or topic.
This link offers a guide to compiling a Pennsylvania Legislative History from free internet resources.
PA State Codes and Regulations
The Pennsylvania Code is an official publication of the Commonwealth of Pennsylvania. It contains regulations and other documents filed with the Legislative Reference Bureau. This link will provide access to the Pennsylvania Code – which includes the full-text of Pennsylvania's administrative regulations. Keyword searching allows searching across the entire Code, as well as within individual code titles. A browse feature is also available.
PA Constitution
In 1776, Pennsylvania enacted its first state constitution, in direct response to the Declaration of Independence and upon instructions of the Second Continental Congress. The above link provides the full text of the current state constitution.
Additional Links
Jenkins Law Library located in Center City Philadelphia offers a number of useful research guides that are specific to Pennsylvania Legal Research.
A listing of local government websites throughout the Commonwealth.
The Pennsylvania Governor's Website which includes links to state agencies as well as to Cabinet Officials and Offices & Commissions.
For an in-depth look at Pennsylvania Legal Resources, please consult the Pennsylvania Legal Research Handbook by Frank Y. Liu, et al.


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Asked by san78 at 12:59 PM on Dec. 10, 2012 in Crazy for CreditsLevel 48 (294,258 Credits)
Answer by Alisim at 1:20 PM on Dec. 10, 2012
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Interview- Borderless: Canadian folk-rockers challenge Americana dominance
For all the hype about the revamping of Americana tunes with an influx of indie-folk bands, the North American music scene is in no way limited to American artists– just ask Toronto-based folk rockers Great Lake Swimmers.
"Music shouldn't have borders around it, but I'm very proud that Canada is doing so well with music right now," says frontman Tony Dekker, little Arcade Fire and Broken Social Scene sprites no doubt appearing in thought bubbles above his head. "I like to think there's something uniquely Canadian reflected in our music."
Heralded as a "national treasure" by Canadian critics, GLS began as a solo singer-songwriter project by the Ontario native in 2001. Gaining steam– and a full five piece band– over the years, the folk-rock ensemble recently released Lost Channels, its fourth studio album, which garnered a coveted spot on the short list for the 2009 Polaris Music Prize, an annual award for best full-length Canadian album.
The Hook: How was making Lost Channels different from earlier albums?
Tony Dekker: I tried to say as much as I could in the short amount of space that the medium requires– I listened a lot to the original Carter family and was fascinated that they could get across big ideas about hardship in such a small period of time. It was an inspiration to try and really use the medium of a song and say everything I had to say.
The Hook: You've said that the move from small-town Ontario to Toronto was a culture shock for you. How is that tension reflected in your music?
TD: On the first album, you can see clearly a part of [my] culture shock– through the course of our albums, people have picked up on themes of the natural world.
The Hook: Critics have consistently raved about your "timeless style." Do you think it's important to modernize the traditional?
TD: I would say we're not making traditional music, but using traditional tools. I was raised on old country and western records, but when I got into music, it was punk rock, DIY music– and that was the lens I used to see music through. I first started playing because of the music of Sonic Youth, the Dead Kennedys, conscious punk rock. I feel we're adding a DIY independent fusion into a traditional base.
The Hook: Reviews have said your music sounds "haunted" and "lonely." Are you haunted? Are you lonely?
TD: Sometimes.
Great Lake Swimmers perform at The Southern on 10/3. Wooden Birds and Sharon Van Etten open. The show starts at 8:00 pm and tickets are $14 at the door.


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Walmart is buying menswear online seller Bonobos, intensifying retail competition with Amazon on the same day its archrival announced its acquisition of Whole Foods.
The nation's largest retailer said Friday that it would pay $310 million for Bonobos, which also has 35 brick-and-mortar shops, as it continues to scoop up niche retail sites.
The move was immediately overshadowed by Amazon's seismic acquisition of Whole Foods, sending Walmart shares down 5.2% in early trading to $74.84.
But it reflects Walmart's bid to grow its customer base into niche areas where its stores are not as strong. The company said it would offer Bonobos brands through its recently-acquired Jet.com division and "possibly other Walmart brands in a variety of countries over time."
"Bonobos is a brand with loyal customers, premium price points, and expertise in a differentiated niche,'' said Stephen Beck, managing partner of management consultancy cg42. "It attracts exactly the kind of buyer who does not frequent Walmart today.''
In recent months, Walmart has begun to offer free two-day shipping for a minimum purchase of $35, and sought to leverage its network of locations by offering a discount on thousands of online-only products if customers are willing to pick them up at a local store.
At the same time, it has been enhancing its online offering by buying other sites. In August, it acquired the online marketplace, Jet, for $3 billion and made that company's top executive, Marc Lore, the CEO of e-commerce for Walmart in the U.S.
The latest addition to the Walmart digital team is Bonobos CEO and founder Andy Dunn, who will oversee Walmart's digital brands.
"Adding innovators like Andy will continue to help us shape the future of Walmart, and the future of retail," Lore said in a statement. "I'm thrilled to welcome Andy and the entire Bonobos team. They've created an amazing product and customer experience, and that will not change. In fact, Andy will be a great influence on the company, especially in leading our collection of exclusive brands offered online."
In December, Jet bought online footwear seller ShoeBuy for roughly $70 million. Two months later, Walmart scooped up Moosejaw, an online outdoor gear and clothing retailer. And in March, Walmart announced that it had purchased ModCloth, an online seller of women's clothing and accessories that targets customers looking for full sizes.
"Apparel and accessories are now the number one category for digital commerce,'' Ravi Jariwala, a Walmart spokesman, said in an interview prior to the Bonobos announcement. "So with so many customers shopping there. as you're looking to grow your e-commerce presence, it's important to be where your customers are . . . . And at the same time these acquisitions do allow us to reach essentially new customers that may have not shopped within our ecosystem in the past.''
Along with potentially ushering new customers into the Walmart fold, the new sites provide deep wells of expertise about products ranging from shoes to apparel, and Walmart has kept the sites' management teams and staffs intact.
The Boston-based ShoeBuy, for instance, kept its CEO Mike Sorabella and staff of roughly 200. ModCloth CEO Matthew Kaness is still in place. And Moosejaw CEO Eoin Comerford and his team are still at the helm of their outdoor-focused site.
"Think about the expertise these teams inherently bring,'' Jariwala said. "Moosejaw has been in business almost 25 years and focused that entire time on the outdoor space so they have deep industry knowledge, deep industry relationships . . . The type of content, visuals, product descriptions you need to sell something like specialty apparel is different than the content you need to sell a video player or box of diapers.''
That knowledge is also being drawn upon to benefit the entire e-commerce network. Moosejaw's CEO oversees the outdoor category for both Walmart and Jet.com, Jariwala says, while Sorabella helms the footwear category for the various sites.
"That will enhance the customer experience for our existing customers,'' he said, while Walmart "can help the business of the companies that are new to our e-commerce family through synergies, through efficiencies in cost of goods and shipping rates.''
Still, Beck said that Walmart's latest acquisition may hobble Bonobos, and not do as much to bolster Walmart's customer base as it may hope.
"Unfortunately, while this may make sense on a spreadsheet or in a conference room, in the real world it represents the end of the Bonobos brand,'' he said, adding that some Bonobos customers were not pleased with news of the pending deal. "Therefore, if Walmart's play is to acquire Bonobos to broaden its appeal to customers who do not see Walmart as relevant, the negative perceptions associated with the Walmart brand and its inconsistencies with the Bonobos brand mean the strategy is doomed to fail."


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If i remember correctly, the last time this happened it didn't end well.
Immaculate conception != virgin birth.
A lot of people make the mistake of equating "Immaculate Conception" to the virgin birth of Jesus. Actually, it refers to the birth of Mary (mother of Jesus) being born without Original Sin. What the author is referring to is the Annunciation, which is the virgin conception of Jesus within Mary.
http://en.wikipedia.org/wiki/Immaculate_Conception [wikipedia.org]
A lot of people making that mistake includes the vast majority of Roman Catholics.
Asexual reproduction isn't the same as virgin birth.
For all we know, that snake is a slut.
First Spielberg/Chrichton makes movie Raptors 6ft tall before they find real ones, now female lizards can spontaneously reproduce?
Someone should be asking those guys about their reality-altering machine.
The mother in question gave birth to not one, but two snake litters of all-female snakes with WW-chromosomes. Male snake cells have two Z chromosomes, while female snakes have a Z and a W. This is the first time a reptile has been seen with two W chromosomes, something thought peculiar to fish and amphibians. The snakes' litters also retained the mother's rare genetic coloring
Also direct links to the study are here [royalsocie...ishing.org] and here [royalsocie...ishing.org](pdf). The paper is "Evidence for viable, non-clonal but fatherless Boa constrictors" by Warren Booth, Daniel H. Johnson, Sharon Moore, Coby Schal, and Edward L. Vargo.
welcome our new immaculate boa overlords (or shall I say overladys?).
And it's actually fairly common in the insect world. Worker bees, for example, lay unfertilized eggs (which, as always, give birth to "drones," or male bees, the same as when the queen lays unfertilized eggs). But for bees, this is almost certainly a throwback to millions of years ago, before the current roles were set in stone -- as drones are incapable of fertilizing non-queens, and workers wouldn't be laying if there were any queens in residence. The modern day outcome is A Bad Day, though in years go
For what it's worth, immaculate conception isn't unheard of in humans: http://journals.lww.com/greenjournal/Abstract/1979/03001/Pregnancy_in_a_True_Hermaphrodite.14.aspx [lww.com]
Last time this sort of thing happened, I remember it didn't end well for the fellow. What was his name?
Oh well. Good luck, baby snake.
> Last time this sort of thing happened, I remember it didn't end
> well for the fellow. What was his name?
I'm not really up on Christian doctrine, but from reading the rest of this discussion, I believe you are referring to Raptor Jesus.
Yet more proof of creationism. Just look at the word parthenogenesis. It's got the word genesis right in it!
Interesting tidbit: The vast majority of known snake species are capable of swimming. Get a snake washed out to sea, let it drift between islands on flotsam, and with this mutation, a lone female is suddenly capable of being the foundation of a new population in a new ecosystem.
While not advantageous to individuals, this female-only birth trait would be a powerful force in mass extinction events, as it leads to a diverse set of multiply adaptive groups being formed, each specialized in a different direction for a different ecosystem niche. If a meteor equivalent hits, and all the rules of living change to some degree, you have a greater chance of having some in the right niche to survive.
The downside is if female-only births become too common, you stand a chance of losing genetic diversity in the smaller groups - so it being in the background like this, only occasionally popping up makes sense for a species that might have gained benefit from it in more ancient life cycles.
Ryan Fenton
If anyone's thinking about cloning any dinosaurs, may this be a warning.
As the story's tag notes, the Immaculate conception refers to the conception of Mary, not Jesus. Next time, samzenpus, aim for the slightly higher hanging fruit when going for the cheap pun.
The Immaculate Conception was the conception of _Mary_ conception so that she would not be burdened by Original Sin, leaving her a suitable vessel for her to carry The Christ Child. It's "Mary _of_ the Immaculate Conception, or _who_ _was_ immaculately conceived.
That isn't even my mythos, but it always amazes me how many people don't have the first clue about the facts of their own. Wasn't there a post here recently that said the people who know the least about faith are the faithful, or maybe it was that
Although science may gasp at immaculate conception in a snake Christians have it from an authoritative source that Virgin births in human females has happened at least once.
1) virgin birth != immaculate conception
2) why the completely unnecessary religious reference? It looks like yet another attempt to insert flamebait in the summary.
Immaculate Conception was Mary, not Jesus
The dogma of the Immaculate Conception has nothing to do with the Virgin Birth of Christ. The Immaculate Conception was the conception of Mary without the taint of Original Sin.
Mary was a snake! It's obvious!
1) immaculate conception != virgin birth
2) why have an unnecessary and irrelevant religious reference at all? It looks like an attempt to put flamebait in the summary (again).
This is quite amazing.
Essentially if the female is unable to find any mate in this year's mating season, it still have the option to reproduce regardless. There is a penalty of having exactly the same genetic code, but I guess it is a much better option than dying without passing any genes at all.
At the same time if the male is available, she can make use of all the advantages of extra genotype permutations that comes with sexual reproduction. It really is a win-win!
This raises the question though: Since it
Wasn't this part of the premise of Jurassic Park? Nature finds a way.
In Catholic Theology, the Immaculate Conception doesn't refer to the Virgin Birth of Jesus, but to the conception of Mary without original sin.
I guess it's possible that these baby boa constrictors are especially sinless, but you probably won't be able to decide on that issue by reading Biology Letters.
I seem to recall reading about this many years ago. Not seeing anything on the web older than a few days though. As I recall it only happens under certain circumstances relating to the age of the snake and specific environmental factors including availability (or lack?) of food, temperature, humidity(?) etc.
Anybody else hear this before?
Immaculate Conception is a whole 'nother thing than parthenogenesis. Has everything to do with (not having) Original Sin, and nothing to do with the messiness of sex leading to conception.
Praise be to Boa Jesus!
Chaos theory at work, ladies and gents. You were warned.
This is why I love science as much as I do: if not for science, we wouldn't have learned that real virgin birth happens in serpents.
Wow. I've never seen a story go dead like this on Slashdot.
Server problems, or just a boring story?
Surely somebody can come up with something witty and biblically snide. Snakes? Immaculate conceptions? I mean, come on!
I for one find the idea of snakes creepy, and self-replicating snakes even creepier. Brr.
Reptiles suck.
That's virgin birth, not immaculate conception. Immaculate conception is what the story tells how Mary was born: no original sin. I'm not even Christian and this is clear to me.
I believe the term you're looking for (and finally spit out in the last sentence) was "virgin birth." Immaculate conception is something else entirely. Specifically, it's the uniquely Catholic doctrine, developed as part of the cult of the Virgin Mary over the past 500 years (finalized only about 100 years ago), that Mary was conceived without sin. God put a kind of "sin shield" around the egg as it was being fertilized apparently, and so she was born without the taint of the original sin (i.e., "immacul
This may sound like a grammar nit, but I found it really distracting to read "commoner" in the summary. Although "commoner" can technically be used as an adjective, it is strongly discouraged due to the potential for confusion with the noun "commoner" which in some sentence constructions can function as an adjective with a somewhat different meaning. For example:
"The commoner dress of the era was rags."
This can be read in two ways:
Daphne dear, I think we should do an inventory of the terrarium.
Raptor Jesus will return!
Virgin birth != immaculate conception
Virgin birth = conceived without sex
immaculate conception - conceived (by sex!) without the taint of original sin
According to traditional (Catholic) Christian beliefs, Christ was born of a virgin, and MARY (not Christ) was born without the taint of original sin
So the two terms refer to two totally distinct events: the immaculate conception occurred a generation before the virgin birth.
So, this is proof that Mary was actually a Boa Constrictor?
Oh, and FP, I think.
LOL. Way to go, Slashdot.
Either Slashcode sucks big hairy donkey balls, or 250+ motherfuckers just jumped in to destroy my first fp try in about ten years. I'll go with the motherfucker theory because Perl code can never, ever fail.
Immaculate conception is not the same concept as virgin birth. If the original sin of Adam and Eve have tainted all births since Genesis, consider what the serpent's offspring have had to deal with.
To the religious minded it may be even more inconceivable that a snake be born without sin than without a father.
Interesting implications if it turns out to be possible in humans too!
"Commoner" is somebody not of the gentry.
OTOH, cool story, half-clones. Almost like an egg cell divided and then recombined somehow.
... This is absolutely fascinating. However, I suppose I might as well be the person to point out that while this is a virgin birth, it's not an "immaculate conception" [wikipedia.org] since that apparently has do with a Catholic doctrine regarding Mary being born free of original sin.
We now return you to your discussion of snake genetics.
interesting and all, but the headline is nonsense. immaculate conception refers to Jesus' mother being herself born free of original sin.
The debate about whether Boas have original sin is theological and not biological.
The Immaculate Conception [wikipedia.org] refers to the birth of Mary (a child conceived without the taint of original sin). The Virgin Birth [wikipedia.org] refers to the birth of Jesus (a child born to a virgin). They are not at all the same thing. You are approximately the 6,696,844,874th person to get them confused.
For those wondering about the calculation:
6,697,254,041 - world population (from Google)
- 409,166 Catholic priests (source [thaindian.com])
- 1 (me)
Considering what young females of our species tell their moms, virgin birth in humans is not a rare thing either.
He told me the Bible was all lizard people
Extremely interesting. What the summary doesn't point out is that the boa had in fact mated with multiple males before this virgin birth, so in fact it could have used the traditional method too. I thought animals only did this when they had no access to sperm.
Jesus was the snake all along?
The son of God was actually born to a snake?
Oh, I'm being eaten
By a boa constrictor,
A boa constrictor,
A boa constrictor,
I'm being eaten by a boa constrictor,
And I don't like it--one bit.
Well, what do you know?
It's nibblin' my toe.
Oh, gee,
It's up to my knee.
Oh my,
It's up to my thigh.
Oh, fiddle,
It's up to my middle.
Oh, heck,
It's up to my neck.
Oh, dread,
It's upmmmmmmmmmmffffffffff . . .
Shel Silverstein
"Commoner"?! - You mean "more common". I guess you'll tell me that 'commoner' sounds betterer....
I'm trying to understand what in TFA means that the snake was born without original sin. It's been a while since I read the Bible, but I seem to remember somewhere near the start that the snake was cast out of the garden of eden for being a bit of a git and had its legs removed. A snake without original sin would therefore have legs.
Can we just say asexual reproduction when we mean asexual reproduction, and leave misquoting the Bible to Christians please?
I guess this explains why there are so many mothafuckin' snakes on this mothafuckin' plane.
There's no such thing as a free lunch. -- Milton Friendman


text:
4G Takes Off
The use of long-term evolution networks -- or 4G -- is also set to skyrocket over the next five years.
By Cisco's measures, 4G networks will support 10 percent of all mobile devices and M2M connections by 2017, a figure that may seem small, but represents a hefty jump from the 1 percent of mobile devices 4G networks fueled in 2012. It also means 4G connections will account for 45 percent of worldwide mobile data traffic within just five years.
Cisco did the math, and figured out 4G traffic will grow 40-fold from 2012 to 2017, representing a 109 percent compound annual growth rate (CAGR).


text:
POTSDAM, N.Y.—Danny Biega scored the tie-breaking goal in the third period and the Harvard men's hockey team killed a five-minute penalty to seal a 3-2 win at Clarkson in the Crimson's first road game of the season Friday night at Cheel Arena.
Clarkson (6-4-3, 1-3-1 ECAC Hockey) tied the game after Eric Kroshus scored first for Harvard (2-2-1, 2-2-1) and Tommy O'Regan netted his first collegiate tally. Steve Michalek logged 30 saves to outduel the Golden Knights' Paul Karpowich, who made 24 stops.
Barely a minute after Clarkson's Matt Zarbo evened the game at 2-2 in the third period, the forward line of Marshall Everson, Luke Greiner and Eric Kroshus battled for the puck along the wall, freeing it for Biega at the point. The junior defenseman rocketed a shot off a defender's leg and past Karpowich for the winning tally with less than seven minutes remaining.
With 5:05 left on the game clock, the Crimson was left shorthanded after being whistled for hitting from behind. Harvard limited Clarkson to three chances during the advantage, and Michalek stopped them all.
Clarkson finished 1 for 7 on the power play, while Harvard was 1 for 9. The Golden Knights owned a 32-27 shots advantage.
Harvard earned the only three power plays of the first period. The Crimson moved the puck well on the first, but its best chance came when Colin Blackwell's one-timer rang off the post. Kroshus converted on the second man advantage. After getting the puck from Patrick McNally, he exchanged passes with Daniel Moriarty and skated in from the left along the goal line. He moved to his backhand to tuck the puck between Karpowich's pad and the post at the 6:18 mark.
The Golden Knights, however, answered the Crimson with their own score just 29 seconds later on a five-hole backhand shot by Nick Tremblay. The Crimson generated several chances in the following minutes, before Michalek kept Clarkson from taking the lead with a stellar save on Louke Oakley.
Karpowich started the second period by denying Alex Killorn on a 2-on-1 chance set up by a pass from David Valek and Blackwell taking a hit at the offensive blue line. The first of four Clarkson power plays soon followed, but the Crimson killed each, including a two-man advantage for the Golden Knights that lasted 39 seconds.
On the first of three Crimson power plays in the middle frame, McNally fired a wrist shot wide that shattered a pane of glass behind the net, delaying the game for about 15 minutes. After the teams came back out, O'Regan gave Harvard the lead by stealing the puck from a defenseman and slipping a shot through Karpowich on a breakaway.
After Karpowich kept the game close in the third period with huge saves on Blackwell on a shorthanded chance and Mike Seward at even strength, Matt Zarbo tied the game with a power-play goal at 12:04. That set the stage for Biega and the Crimson penalty killers.


text:
July 29, 2011 > Your Teen May Need a Whooping Cough Vaccination
New Rules Require Students to Get Immunized Before School Starts
If you have a child in middle or high school, he or she needs to get a whooping cough vaccination before going back to school this year. Whooping cough, also called pertussis, is a highly contagious bacterial disease that can cause uncontrollable coughing. After California experienced a significant spike in cases last year, a law was passed requiring all students entering grades 7 through 12 to get a whooping cough booster called Tdap. Some students may have an additional 30 days after school starts to get vaccinated due to a new state law that gives schools the option of allowing students to attend class as long as they get the Tdap within 30 calendar days of the start of school. According to the California Department of Public Health, there were about 8,000 cases of whooping cough in California last year, more than any other year since 1947. Previously, the peak was 3,184 cases reported in 2005. "Whooping cough is a serious public health threat," said Ruth Traylor, community outreach director at Washington Hospital. "The disease is most contagious before the coughing starts, so students can easily infect each other and members of their household before they realize they have whooping cough." The respiratory infection at first resembles an ordinary cold, but can turn serious and even deadly. Often a whooping sound can be heard as the infected person breathes in after coughing. The bacteria are spread from person to person when someone with the disease coughs or sneezes. The best way to protect against whooping cough is by getting a vaccination, according to Traylor. "Those who have not been vaccinated or have lost their immunity over time, or people with compromised immune systems, are most at risk," she said. "Babies seem to be at greatest risk of death due to whooping cough. They are too young to be fully immunized." While most adolescents and adults receive the Tdap, children under age 7 are vaccinated with the DTaP. Both formulations also protect against tetanus and diphtheria, Traylor said. Combining the vaccines reduces the number of shots needed, she explained. It takes five doses of DTaP to build up enough antibodies to protect against whooping cough, she added. Babies get their first dose between the ages of 15 and 18 months and should have their fifth dose before they start kindergarten.Booster Needed to Stay Protected "The immunity from the vaccine wears off over time, requiring a booster shot to stay protected," Traylor said. "It is generally recommended that adolescents and adults get immunized against whooping cough every 10 to 15 years." The dramatic rise in whooping cough cases last year focused attention on the need for adolescents and adults to get re-vaccinated against whooping cough, she added. The new law takes effect this school year and affects all students in grades 7 through 12. Students in those grades will be required to show proof of a Tdap shot before starting school or within 30 days depending on the school, according to the California Department of Public Health. For the next school year (2012-2013), only students entering 7th grade will need to show proof of a Tdap. Students can get the vaccine from their primary care doctor, Traylor said. To make it easier for families in the Tri-City area, Washington Hospital is offering special vaccination clinics at school sites in the Fremont and Newark Unified school districts, she added. To learn more about these special clinics, call (510) 608-3203. For those without health insurance or a primary care provider, Washington Hospital is offering the vaccines through its Washington on Wheels (W.O.W.) Mobile Health Clinic. The W.O.W. van will provide walk-in whooping cough vaccinations (Tdap) every Tuesday at the Fremont Family Resource Center, 39155 Liberty Street in Fremont, from 9:30 a.m. to 3:30 p.m. Parents should check with their child's school to determine whether their child must get the vaccine before starting school or if they have an additional 30 days to get the Tdap. For more information about whooping cough and where to get the vaccine, visit www.whhs.com/cough or call (510) 608-3203.


text:
New Delhi: Prime Minister Manmohan Singh on Wednesday met Myanmar's pro-democracy iconic leader Aung San Suu Kyi and discussed the process of national reconciliation and democratisation in her country. (Agencies) Latest News from India News Desk
Talks between Manmohan Singh and Suu Kyi lasted for half-an-hour following which they met without aides, said official sources. Expressing his happiness at receiving her in New Delhi, Manmohan Singh thanked her for accepting the invitation to deliver the Jawaharlal Nehru lecture.
In his interaction with Suu Kyi, the Prime Minister said: "Our good wishes are with you as indeed with your struggle for democracy. We admire you for the indomitable courage you have shown". "The two discussed a variety of issues including the national reconciliation process underway in Myanmar and the process of democratisation in this context.
Prime Minister welcomed the progress made by Daw Suu Kyi and President Thien Sien," said sources. "They agreed that people-to-people relations were important. There was also a discussion about greater cooperation between the parliaments and judiciaries in the two countries," he said.
Suu Kyi began her six-day visit to India on Tuesday, her first trip to the country where she studied after a quarter century. "It is good to be back in India," the Nobel laureate told a TV news channel on Wednesday morning. "...I am glad that I can still recognise parts of Delhi," she said.
Suu Kyi studied at the Convent of Jesus and Mary School and graduated in political science from Lady Shri Ram College, one of Delhi's most reputed colleges for women, when her mother was Burma's envoy to India. She is expected to meet students and the faculty of LSR, as her college is known.
On the political level, she said she wanted closer relations between the people of the two countries because a gulf had emerged in recent years.
Suu Kyi and her mother -- Suu Kyi's father was a friend of Nehru -- lived in the 1960s on 24 Akbar Road, now the headquarters of the Congress party. Suu Kyi is also scheduled to meet Vice President Hamid Ansari, Lok Sabha Speaker Meira Kumar, Congress president Sonia Gandhi and External Affairs Minister Salman Khurshid.
She will visit The Energy and Resources Institute (TERI) in Gurgaon, before flying to Bangalore and Andhra Pradesh. India honoured Suu Kyi with the Jawaharlal Nehru Award for International Understanding in 1992 while she was under house arrest under the military government in Myanmar.
New Delhi: Prime Minister Manmohan Singh on Wednesday met Myanmar's pro-democracy iconic leader Aung San Suu Kyi and discussed the process of national reconciliation and democratisation in her country.
Latest News from India News Desk


text: traumatic brain injury Organizers: New Veterans' Center In Carbondale Will Meet A Need By Marci Krivonen • Mar 27, 2014 Flickr/Russell Sellers An effort is underway to expand services for local veterans and better tackle problems like Post Traumatic Stress Disorder and brain injuries. It's estimated more than 14,000 veterans live in the Roaring Fork and Colorado River Valleys and, a center is opening up before summer to help deliver services to them. Aspen Public Radio's Marci Krivonen reports.


text:
My stepson was due for shots - TWO of them - in order to return to school. I can't remember what the two shots were, but he ended up getting six. One of the six was the HPV vaccine.
Just FYI: I did not take him to get his shots, his BM did. DH & I do not vaccinate our children together. We did until the age of 3 when one suddenly had extreme signs of aggression & still struggles with it. Our 6 year old twins were vaccinated until 3, our 4 year old until 1, and our almost 2 year old has had no shots.
Anyway, when BM dropped him off after getting his shots, she told me how many he got. My jaw dropped, four shots that were not required for him to return to school were given to him - I'm really wishing I would have just written a letter saying we no longer vaccinate, but it's too late for that. So he got a chicken pox booster, and the HPV. I'm not sure what others he got, but those are the 'extras' that she told me about. The first thing out of my mouth was "Gardasil, you got him the Gardasil shot?!!?" She immediately looked appauled and said "NO!" .... I've been researching since I got home this evening (I had a long day at the hospital with one of the twins), and the only shot I can find for boys is, in fact, gardasil.
There have been a lot of deaths and serious life altering side effects because of this shot. I'm devestated by the fact that she unnecessarily gave her son (a child who has lived in my home and been a part of my life for almost 8 years, and I raise everyday) a shot that she had no idea what it was.
What is your stance on Gardasil? Is it something you would give your child? Especially a 12 year old who isn't even interested in the opposite sex?
BM texted me today to ask if SS was okay. I told her he has had headaches for the last two days, but that I didn't know how he was today since DH gets him off for school & I sleep with the littles til' they get up. "Okay thanks. I read up on the shot and the paralysis it may cause and don't want him to be worried about it. I believe we worry about it enough." was what she said in response. I think she's a bit worried about it now that she realizes that she gave him this specific shot without even thinking about what it was. She just assumed they wouldn't give him something dangerous? What, like wheat isn't dangerous to his body, and you continue to give it to him? ... Whatever, I'm really irritated.


text:
Revision as of 16:51, 16 August 2009 by D a carver.yahoo.com (Talk | contribs) (→Chapters)
The Documentation Guidelines maintain a reference to important information when using the Eclipse Wiki for single sourcing eclipse project documentation. The eclipse documentation guidelines are heavily influenced by two very successful open source documentation projects:
This guide will may make reference and where appropriate cite the various sections from these guides.
The goals
The DocumentationGuidelines are made of of several pages and sub-pages. This section as well as the Category:Documentation and Category:Draft_Documentation pages can be used to review the relevant chapters.


text:
Residence: Hendersonville
What is a book artist?
A book artist is a person that puts their creative ideas into the form of a book. Some people fold books, some cut designs into the pages and some like to paint the pages. I have done a little bit of everything with them, but I enjoy the folding the best.
What is the process?
Once I have a request for a book, I try to find out a little bit about the person that the book is for. Sometimes I can locate a book that compliments them and that makes it a little more personal. For instance, if the book is for a baseball fan, I will try to find a book that has their team's favorite colors on the hardcover. Afterward, it involves some simple math to center the word in the book, and then I start folding the pages into a design.
What kind of books do you make?
The majority of books that I make have been for sports teams. NFL teams seem to be a favorite among requests. Also, first and last names are high on the list. If I can find a book that will hold the word or words, I can usually fold them into the book.
Who do you make the books for?
I get requests to make books for individuals, businesses and schools have used them in auctions to raise money. I donate folded books to local charities when they have special events where they give away door prizes. A lot of individuals are requesting wedding books where I fold the book with the bride and groom's name, or the wedding date.
When did you start your business Candies Book Art and how many books have you made?
I started folding books at the end of 2011 after much trial and error and practicing while sitting at our local bar, The Dugout. I decided to start selling them for a little extra money. Business has been good so far, word of mouth, and good friends have helped me start to grow my business with an estimated 400-plus books sold in the last year.
What was your most unusual request and why?
Believe it or not I have not had any unusual requests as of yet; some funny nicknames, but everything has been normal so far. I'm looking forward to unique requests though, and I am sure they are out there waiting to be folded for that special someone.
How did you get into the craft?
In 2011, I was laid off from my job that I had been employed at for 6 years. I spent hours each day looking for a new career and something to focus on. I ran across a picture of a folded book and was hooked. I would spend hours late at night working on the formula to create the alphabet into the pages of the book. It took me about a month and half to get it figured out and entered onto a spread sheet. I made the capital letters first, then last year I was able to work on the lower-case alphabet. Next challenge will be a cursive or script font, at some point in the future.
What do you like most about creating book art?
I love books, and in this day and age most people are using e- readers, including myself. I had hundreds of hardback books lying around my house, collecting dust. I decided to recycle them into art. They can still be used to read, displayed on a shelf or table and some lucky person gets to have a unique piece of art. I like the fact that the books find a new home and are repurposed in an unusual way.
What is the most challenging part of creating book art?
I find the most challenging part for me is keeping up with my count on the pages. When I am uptown folding a book, I have people stop and ask me questions (which I love.) But I tend to get distracted and lose my place in the folding process. I have missed letters in the word or realized I spelled the word wrong.
It's trial and error.
What are some of your customers' reactions when they see the finished product?
Most people are amazed that it can be done. I love the look on their faces, just seeing them smile and telling me how it's going to look in the house or that they are taking the book to work and displaying it for everyone to see.
If someone wanted to request a book, how would they contact you?
If you would like to request a book or have questions, I can be reached by phone at 843-267-8911, leave a message or send a text. I can also be reached by email at email@example.com, or you can visit my Facebook page Candies Book Art. Leave me a message and I will contact you as soon as possible.
Got a Minute with Candie Ray
Residence: Hendersonville


text:
Munchie Legaux threw for 262 yards with two touchdowns and also ran for another, as the 21st-ranked Cincinnati Bearcats rolled over the Fordham Rams, 49-17, Saturday at Nippert Stadium.
Travis Kelce had 101 receiving yards with a score and Danny Milligan also caught a touchdown pass for the Bearcats, who rang up 472 yards of total offense on the night.
R.D. Abernathy carried the ball five times for 51 yards and a score, while Jordan Luallen and Brendon Kay each had short touchdown runs for Cincinnati (5-0), which improved their win streak at home against non- conference opponents to 24 games.
George Winn had a game-high 75 rushing yards on 13 carries and on defense, Deven Drane staked the Bearcats to an early lead when he returned a fumble 76 yards for a touchdown in the first quarter.
Rams quarterback Ryan Higgins completed 31-of-42 passes for 262 yards and a touchdown, and Carlton Koonce rushed 22 times for 72 yards for Fordham (4-3).
Sophomore receiver Brian Wetzel caught nine balls for 121 yards and had the Rams' lone touchdown, and Patrick Murray was 3-of-4 on his field goal attempts, hitting a 55-yarder in the second quarter in defeat.
Cincinnati's defense put the Bearcats out to a quick 7-0 lead after Fordham received the opening kickoff and drove down to threaten inside the Cincinnati red zone.
After converting on 4th-and-1, Higgins dropped back to pass on first down, but was sacked by defensive lineman Dan Giordano. The ball came loose and Drane was able to scoop it up at the 24 and run it back for the game's first score.
Fordham bounced back, however, and immediately drove down the field again to get to the Cincinnati 28. But the Rams were unable to move the ball further, and settled for a 46-yard field goal from Murray that made it a 7-3 game.
It didn't take long for Cincinnati to respond, however, as Legaux hit Kelce in the flat on a 5-yard out three plays later, which the senior tight end managed to turn into a 78-yard touchdown reception.
After Murray missed a 48-yard attempt early in the second quarter, he connected on a 55-yard try with 43 seconds left in the first half to make it a 14-6 game.
The Bearcats' offense came to life after halftime, though, with Legaux leading them on a 9-play scoring drive to start the third quarter, which he ended with an 8-yard TD run.
After a three-and-out by Fordham, Cincinnati struck again on a 5-play, 81-yard drive, with Abernathy finding the end zone on a 36-yard run.
Luallen tacked on another score late in the third, getting the ball on 1st- and-goal from the 1-yard line on Cincinnati's next possession and putting the Bearcats ahead 35-6.
Fordham finally found the end zone at the 1:28 mark in the third, when Higgins hit Wetzel for a 12-yard TD throw to cap a 7-play, 68-yard drive.
Cincinnati tacked on 14 more points in the fourth quarter compared to just a field goal for the Rams, with Milligan catching a 29-yard throw from Legaux with 12:48 left and Kay rushing for a 1-yard score with under two minutes to play.
Game Notes
The game was the first meeting between two of the oldest programs in college football. Fordham (1881) and Cincinnati (1885) both trace their lineage over 125 years and have combined to play over 2,000 games (2,424) ... Fordham was 2-for-2 on 4th-down conversions ... The Bearcats finished with 262 yards on the ground and 210 through the air.


text:
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Acapulco, Mexico
series: Body Electric
air date: 12/13/13 6:00 AM
Jane, Berneice, and Margaret lead you through a spirited workout poolside at the Mayan Hotel in tropical Acapulco.
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Thursday, April 27, 2006
Separted at Birth
Since he committed to the Irish, Claussen will have to learn the words to the Notre Dame Victory March. He could have saved some time by committing to Ole Miss or UNLV since he already knows "Rebel Yell."
7 comments:
I think he looks more like this this guy.
Deryk from Sum 41
- April 27, 2006 4:36 AM
- Yost said...
Yeah, I must admit you're right there.
- April 27, 2006 4:44 AM
- CrimeNotes said...
A commentor elsewhere suggested that he looks more like Lisa Simpson. I'm going to vote Lisa Simpson, because I don't want Billy Joel's good name tarnished by a Clausen.
- April 27, 2006 10:27 AM
- The King said...
What he really looks like is John Hotti, but I'm not going to get into that here.
He does not look like Billy Idol. He has a similar hairdo, in a different color. And that's it.
- April 27, 2006 11:08 AM
He definitely was born on the wrong coast and should be part of the Hotti crew.
As an alternative though, it's been suggested that he could put chrome all over his car and become the fourth Icy Hot Stunta.
- April 27, 2006 12:46 PM
I thought he looked weallt tewwt in this photo.....
- April 27, 2006 1:13 PM
- Oregonweim said...
I love all my Notre Dame friends telling me how humble he really is... yeah.
- April 27, 2006 9:55 PM


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Submission + - Amazon's Free Graphic Novel Could Become A Movie? (corporate-ir.net)
destinyland writes: Amazon's just announced that they're giving away a free graphic novel — a supernatural "horror" comic set during the Civil War — that you can read online or with a Kindle app (or the Kindle Fire tablet). But it looks like Amazon's ultimate plan is to film it as their own movie. "If we made this comic into a full-budget feature film, would you go see it?" Amazon asks on the first page of the graphic novel. In the last two years, "Amazon Studios" pored through more than 10,000 possible movie screenplays, and ultimately settled on just 17 finalists (along with nine possible TV series), saying crowdsourcing convinced them to test this idea "for viability as a major motion picture."


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Did you read today's front page stories & breaking news?
From the Wires
How You Can Make Your Brain Healthier, Slow Potential Memory Loss
-- Live Internet Chat with Leading National Brain Health Expert --
By: PR Newswire
Nov. 20, 2012 06:00 AM
SEATTLE, Nov. 20, 2012 /PRNewswire/ -- Individuals and families across America are invited to ask questions of a leading national expert on brain health on ways to increase cognitive fitness and delay the potential onset of memory loss. Emeritus Senior Living National Director of Brain Health Dr. Paul Nussbaum will hold a live Internet chat at 4 p.m. ET / 1 p.m. PT, Monday, Nov. 26. To participate, visit www.Emeritus.com and click on "Click to read more" on the event announcement at the top of the homepage.
Emeritus, the nation's largest assisted living and memory care provider, offers brain health programming designed by Dr. Nussbaum at its more than 470 senior living communities in 44 states. In addition to his position with Emeritus, Dr. Nussbaum is a clinical neuropsychologist and adjunct professor of neurological surgery at the University of Pittsburgh School of Medicine. He is the author of Save Your Brain.
Brain health questions can be submitted online during the live chat or before the event to firstname.lastname@example.com.
Among the topics likely to be discussed are:
"While researchers continue to search for a cure or preventive measure for Alzheimer's, the good news is that there are specific steps each of us can take right now to increase the health of our brain and slow the potential onset of memory loss," Dr. Nussbaum said.
About Emeritus Senior Living
Emeritus Senior Living is the nation's largest memory care and assisted living provider, with the ability to serve nearly 50,000 residents at more than 470 communities throughout 44 states. Emeritus offers the spectrum of senior residential choices, care options and life enrichment programs that fulfill individual needs and promote purposeful living throughout the aging process. Its experts provide insights on senior living, care, brain health, and caregiving topics at www.Emeritus.com. Emeritus is based in Seattle, Wash.; its common stock is traded on the New York Stock Exchange under the symbol ESC.
SOURCE Emeritus Senior Living
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The youth of First United Methodist Church will provide a special 6:30 a.m. Sunrise Service on Easter morning in the church's fellowship hall.
Immediately after the Sunrise Service and continuing until 10:30 a.m., an Easter Breakfast will be cooked and served by the youth in the church dining room. A freewill offering will be received for supporting their summer mission trip.
The traditional Easter worship service begins at 8:30 a.m. The Jubilee Ringers bell choir will play "He's Risen, Hallelujah." The Chancel Choir, under the direction of Rachel Faidley, will sing "Go Ye Into All the World." There will be a special Easter dramatic reenactment "On the Road to Emmaus." Jean Ibbotson will be the organist. Pastor Gary Marzolf will present the Easter message. The FUMC praise team will lead the 11 a.m. contemporary Easter service, with Pastor Marzolf giving the Easter message.
A nursery will be provided during both worship services. All are welcome to attend.


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QOS BASED RESOURCE MANAGEMENT FOR INTERNET APPLICATIONS by Yan Yang A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (COMPUTER SCIENCE) December 2010 Copyright 2010 Yan Yang
Object Description
|QoS based resource management for Internet applications
|Yang, Yan
|Author email
|firstname.lastname@example.com; email@example.com
|Doctor of Philosophy
|Document type
|Degree program
|Computer Science
|Viterbi School of Engineering
|Date defended/completed
|Date submitted
|Restricted until
|Date published
|Advisor (committee chair)
|Golubchik, Leana
|Advisor (committee member)
Horowitz, Ellis
Kuo, C.-C. Jay
|In recent years, many Internet based applications have arisen to take advantage of widespread inexpensive broadband connections. However, congestion on Internet is still significant. Therefore, efficient management of Internet resource that lead to improvements in Quality of Service (QoS) for Internet based applications remains an important problem. In this dissertation, we focus on this problem in the context of several important applications.; Specifically, we consider three classes of Internet based applications, as follows. File downloading is an important class of applications, due its high bandwidth usage, mainly due to the success of applications such as BitTorrent (BT). While the current BT systems use a single torrent based approach, torrent files are related to each other and empirical evidence suggests that most nodes participate in multiple torrents. Consequently, in this part of the dissertation, we propose a multi-torrent BT system and illustrates that our approach improves the overall system performance provides incentives for nodes to act as seeds.; The use of P2P-based design in providing large scale video streaming services has become more popular due to its effective use of Internet and server resources. Live streaming and Video-on-Demand (VoD) streaming are typical examples which can take advantages of a P2P-based approach. In this part of the dissertation, we focus on a number of fundamental open questions in designing P2P-based VoD systems. We explore practical solutions to these questions and show they result in better QoS.; Although P2P-based design of VoD systems received much attention in recent years, most existing VoD systems do not have built-in incentives. In this part of the dissertation, we consider a BT-like VoD system and study the following questions: (1) why an incentive mechanism is needed, and (2) what are appropriate incentives for a BT-like VoD system. We propose a layered coding based incentives approach and show that: (a) our approach does provide better incentives than BT's current Tit-For-Tat (TFT) mechanism, and (b) our approach improves system performance as well as uses system resource efficiently.; Uploads correspond to another important class of Internet based applications. In this part of the dissertation, we consider the following problem in the context of Bistro, a system that focuses on collection of data over the Internet. We focus on a data assignment problem within the Bistro fault tolerance protocol. We formulate this problem as a non-linear optimization problem and develop a genetic algorithm based heuristic as an approximation. We show that our approach is more accurate than several simple heuristics used for comparison, and efficient, as compared to a brute-force approach.
|distributed system; incentives; peer-to-peer; QoS; resource management; streaming
|Part of collection
|University of Southern California dissertations and theses
|Publisher (of the original version)
|University of Southern California
|Place of publication (of the original version)
|Los Angeles, California
|Publisher (of the digital version)
|University of Southern California. Libraries
|Electronically uploaded by the author
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|University of Southern California
|Yang, Yan
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|Libraries, University of Southern California
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|Los Angeles, California
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|University of Southern California
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|QOS BASED RESOURCE MANAGEMENT FOR INTERNET APPLICATIONS by Yan Yang A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (COMPUTER SCIENCE) December 2010 Copyright 2010 Yan Yang


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Software Development
Curtis Tsang, CEO Ying Leung, Principal Consultant
Smart Development Environment 2.0
Visual Paradigm
If Visio jolted the development world in years past, Smart Development Environment (SDE) is jolting us today. The team at Hong Kong–based Visual Paradigm has now morphed their stand-alone Java and UML modeling environments to provide the same functionality across nine popular IDEs: Microsoft Visual Studio .NET, Eclipse/WebSphere, JBuilder, NetBeans/Sun ONE, IntelliJ IDEA, Oracle JDeveloper and BEA WebLogic Workshop. Now, Java developers can use the capable code-development facilities in their favorite IDE with UML 2.0 round-trip synchronization to generate Java and EJB code from UML models, generate UML models from Java and EJB code, and a whole lot more. SDE models employ a resource-centric display: Hover over a diagram element, and SDE adorns it with all valid UML symbols that can be used.
Not only does SDE support UML use case diagrams, it lets you associate multiple descriptions with each use case. SDE then dissects the use case to identify candidate classes, and even provides automated support for CRC card definition. The mouse-gestures capability grabs the "cool feature" laurels: You can create new modeling elements in your diagrams just by moving your mouse pointer according to a prescribed recognition pattern. You can add any Visio drawing to any UML diagram, and create your own stencils and shapes. The Visual Studio version supports round-trip engineering for C#, VB, C++ and ASP.NET projects. Plus, SDE is fast!
Gary Evans
Productivity Award Winners
MagicDraw UML 9.0
Headquartered in Golden, Colo., No Magic has released a winner: MagicDraw UML, a well-designed and highly usable UML modeling tool that supports UML 2.0 notation and the UML 1.4 metamodel. While highly Java-centric, it also supports C#, C++, WSDL, XSD and CORBA IDL, and can generate GoF design patterns and JUnit test patterns. Database schema modeling is supported via JDBC connectors, with improved Oracle round-trip engineering support in this version. It integrates with many popular Java development environments, including Borland JBuilder, Sun ONE, Eclipse, NetBeans and IntelliJ IDEA. Teams can collaborate on a single model using Teamwork Server, and the new visual-model differencing feature makes it easier to see changes between two versions of a model. A 100 percent Java application, MagicDraw can also be extended with plug-ins written in Java or Jython.
John Lam
Together Designer 2005
From Scotts Valley, Calif., Borland is a perennial favorite at the Jolt Awards for one simple reason: Its products work really well. Together Designer is geared toward project teams that need good requirements-modeling functionality but still require the code-generation features that made Together famous. I've used Together for years for its round-trip code-generation abilityif a modeling tool isn't intimately connected with source code, it simply doesn't offer the power that application developers need. Together is one of a handful of tools that meet my mission-critical needs.
Together Designer enables you to create platform-independent models (PIMs) using the UML, and from those PIMs generate code for either the .NET platform as C# or C++ code, or the J2EE platform as Java code. Most important, your models and code stay in sync as you work, ensuring that they remain first-class artifacts.
Scott Ambler
Rational Software Architect
UML design tools are gaining popularity, and IBM's Rational Software Architect (RSA) is probably the most complete and refined UML-centric design tool available. It provides UML 2.0 modeling capabilities and coverage of diagram notations. RSA also has excellent support for working with design patterns, including uniquely extensible support for creating new patterns. And its heritage is strong. Built on the Eclipse 3.0 IDE, RSA provides a seamless extension that matches the quality and consistency of the Eclipse UIsomething that can't be said for many other design tools that feel like add-ons rather than integrated tools. In addition, RSA offers enterprise application developers class-diagram editing of data-layer objects, Web services support, high-quality presentation-layer design tools, and integration with popular Rational tools and processes such as RequisitePro and RUP.
Mik Kersten


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New Jersey Governor Chris Christie to Attend Stevens Institute of Technology Homecoming on Oct. 4, 2013
Hoboken, N.J.—New Jersey Governor Chris Christie will be the guest of honor at a special Stevens Institute of Technology event to mark the launch of two innovative technology projects to spur science, technology, engineering and mathematics (STEM) education and fuel innovation and economic growth. The event, which will take place during Stevens' 2013 Homecoming celebration, is scheduled for Friday, Oct. 4 at 1:30 p.m. on the lawn in the center of the Stevens campus in Hoboken, N.J.
Gov. Christie will be welcomed by Stevens President Nariman Farvardin and Chairman Emeritus Larry Babbio to the pre-Homecoming celebration. "Enabling Innovation" is the theme of the event, which will focus on the impact a recent $7.25 million award from State of New Jersey bond funds will make on enhancing the information technology infrastructure at Stevens. The funds will support two pioneering IT infrastructure projects, the Unified Communications and Collaboration Environment (UCCE) and the Virtual Learning Environment (VLE), which will have a transformative impact on faculty and student capabilities to engage with course content, collaborators, and graphic- and computing-intensive technology applications for learning. These upgrades will position Stevens as a national leader in delivering STEM education using state-of-the-art technology tools.
Stevens is a leader in educating the next generation of technology talent for New Jersey's workforce. Home to three national research centers of excellence, the university was recently ranked seventh in the nation and first in New Jersey in the percentage of STEM degrees awarded as well as seventh in the nation and first in New Jersey in the number of engineering master's degrees awarded. PayScale recently ranked Stevens third in the nation and first in New Jersey for mid-career salaries of graduates and ninth in the nation and first in New Jersey for return on investment of a college education.
"The link between technological innovation and economic growth is well known," said Stevens President Nariman Farvardin. "Stevens is proud to be known as 'The Innovation University,' grateful that the State of New Jersey is investing in our future, and delighted to welcome Governor Christie to our campus. Through these projects, Stevens will create a state-of-the-art technological infrastructure befitting the next generation of technological innovators who will fuel our state's and nation's economy."
The Stevens community—students, faculty, staff, alumni and parents—as well as other invited guests are welcome and encouraged to attend the Enabling Innovation event with Governor Christie.
About Stevens Institute of Technology
Stevens Institute of Technology, The Innovation University®, is a premier, private research university situated in Hoboken, N.J. overlooking the Manhattan skyline. Founded in 1870, technological innovation has been the hallmark and legacy of Stevens' education and research programs for more than 140 years. Within the university's three schools and one college, more than 6,100 undergraduate and graduate students collaborate with more than 350 faculty members in an interdisciplinary, student-centric, entrepreneurial environment to advance the frontiers of science and leverage technology to confront global challenges. Stevens is home to three national research centers of excellence, as well as joint research programs focused on critical industries such as healthcare, energy, finance, defense and STEM education and coastal sustainability. The university is consistently ranked among the nation's elite for return on investment for students, career services programs and mid-career salaries of alumni. Stevens is in the midst of a 10-year strategic plan, The Future. Ours to Create., designed to further extend the Stevens legacy to create a forward-looking and far-reaching institution with global impact.


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Department of Nursing
Bachelor of Science in Nursing
A BSN degree from the University of Central Missouri opens the door to a variety of rewarding and flexible career opportunities in the health care industry.
This highly competitive program offers a wide-range of learning and hands-on experiences in a range of medical facilities.
- Student groups like the Student Nursing Organization offer a sense of community.
- Foundation and departmental scholarships are available.
Online RN to BSN
The RN-BSN program offers a greater understanding of the health care industry by enhancing critical thinking and communication skills. Attaining an RN-BSN degree leads to a greater chance of employment and more career options.
- Flexible courses fit your schedule
- Completion attainable in one calendar year
- Recognized nationally as a "Best Buy"
Master of Science in Nursing
The master's program has two areas of emphasis: Nurse Educators and Family Nurse Practitioners. This degree offers more career opportunities in administration, research, consultation, private practice and more.
- Availability of online courses provide flexibility
- Focus your career with a specialty concentration


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Bethanie Mattek is totally like the Michael Jordan of tennis fashion. She can be anywhere on the court (even off it) and hit her mark every time. Even on her deathbed she'll come up with stuff like this!
By the way, Ms. Mattek, if tennis doesn't work out, there's always Broadway.
Thanks to Stephanie Myles over at Open Court for digging up the deets (and pics) of Mattek's November 2009 wedding to insurance man Justin Sands.
She wore a black Romona Keveza dress and some zebra-print stilettos from Marciano (hmm, nothing from her tennis clothing sponsor, bebe?). And her 5.5 carat engagement ring almost doubled in weight with her 3.5 carat wedding band — made with black and white diamonds to resemble zebra stripes.
Other minutiae: She skipped the Aussie Open to get hitched. When she returns on the court, you'll see her name on the scoreboard as Bethanie Mattek-Sands.
Mazel tov, Bethanie!


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Welcome to Ultimate Subaru Message Board, my lurker friend!
|Welcome to Ultimate Subaru Message Board, an unparalleled Subaru community full of the greatest Subaru gurus and modders on the planet! We offer technical information and discussion about all things Subaru, the best and most popular all wheel drive vehicles ever created.
We offer all this information for free to everyone, even lurkers like you! All we ask in return is that you sign up and give back some of what you get out - without our awesome registered users none of this would be possible! Plus, you get way more great stuff as a member! Lurk to lose, participate to WIN*!
* The joy of participation and being generally awesome constitutes winning
** Not an actual guarantee, but seriously, you probably won't regret it!
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gotta gremlin
Posted 27 November 2005 - 04:35 PM
Posted 27 November 2005 - 06:13 PM
86 turbo wagon. just swapped a previously running engine into it. had it crank, started for a couple seconds, now when i turn the key there is no power, just a very dim oil light coming on. checked the fusable links and they're all there, even did continuity test on the backs of em to make sure. any idea what this sudden loss of all power could be? oh and the button that locks and unlocks the rear hatch still works for some reason..... AHH
Did you check the fuses under the dash? I had a fuse blow under the dash that did what you have described. Does it try to turn over? If it tries to turn over but doesn't start then check timing belts.
Posted 27 November 2005 - 07:54 PM
Posted 27 November 2005 - 08:25 PM
Posted 27 November 2005 - 08:32 PM
checked all fuses even under dash, battery is fine is less than a year old optima and has been starting my z the entire time. the thing is that it has pretty much no power whatsoever. the only signal that there is some power getting from the battery is that the oil light comes on in that bar of red lights, but is incredibly dim, and the hatch button works
Check your grounds. My friends and I have had trouble with bad grounds on these cars and that would do it. Sometime the cable from the battery to the car body is corroded or broke.
Posted 28 November 2005 - 12:12 AM
the rx would have intermittent power, but only after I opened and closed the door, turns out it was a bad connection with a fuse link, iirc, the green one opposite end of the black one
the brat, dead unless I run a wire from the alternator B+ terminal to the battery, which also has the car white wire?
if it will start, but not charge, the 2 terminal connector on the alt may be disconected
if it will show 18+, you are running from the alt
Posted 29 November 2005 - 06:10 PM
Posted 04 December 2005 - 02:17 PM
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text: A Stoughton firefighter displaced from his Abington home by a Dec. 21 fire said he has been overwhelmed by the support from his fellow firefighters. An electrical problem caused the fire that heavily damaged the Doris Drive home of Jack Hussey, his wife, and daughter, and they have been living with relatives since the blaze. Hussey started his firefighting career as a call firefighter in Abington and knew many of the firefighters from Abington, Rockland, Whitman, and Holbrook who responded to the fire. Stoughton firefighters also responded to the blaze to give him support. Two funds have been set up to aid his family, one by the Professional Firefighters of Massachusetts and the other by Stoughton firefighters. "This event, while unfortunate, has given me a new perspective on the aftermath of how a fire like this affects a family,'' Hussey said, "and I hope to be able to counsel fire victims in the future."


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BARRINGTON — Four candidates for state representative are running for two open seats in District 4, which consists of Barrington.
On the Nov. 6 ballot will be Republicans Bill O'Connor, an incumbent, and Devon Claire Boyd. On the Democratic side are candidates Ken Grossman and Dennis Malloy.
O'Connor, 43, of 145 Beauty Hill Road, is an airline pilot and a six-year Barrington resident. He is the chairman of Strafford County Republican Committee and member of N.H. House Science, Technology and Energy Committee.
"I am running for re-election to continue the work from last term of making our state government more affordable, efficient, and accountable to taxpayers," said O'Connor in a recent email. "The only way to reduce taxes is to reduce spending, and N.H. citizens need to keep more of their own money."
Malloy, of 112 Stone Farm Drive, is a Barrington selectman who has lived in town for 10 years.
He said in a recent email that he's running for state representative because he feels strongly about he tone of the current debate in the Legislature.
Malloy also emphasized that investment in education is critical.
"Funding for New Hampshire's public schools, colleges and universities keeps college affordable and helps produce the next generation of leaders and entrepreneurs who are essential to our future," said Malloy.
He also stated support for balanced budgets that "meet our needs, helps create a stable economic base and encourages new business development. Our elected officials have a duty to ensure that our revenues match our expenses every year."
Grossman, 69, of 435 Scruton Pond Road, is a retired educator who now works in real estate. He has a doctorate in educational leadership from the University of Massachusetts in Amherst. He serves on the Barrington Conservation Commission.
Grossman said support for public education, particularly for K-12 schools, is his biggest issue during this election year.
"I'm running to see that New Hampshire's quality of life in business climate, educational opportunities, health care, and environment don't fall victim to our state Legislature's misguided efforts to remove the State of New Hampshire from responsible support of these areas of concern," he wrote in a recent email.
Boyd could not be reached for this article.
Four candidates running for two seats in Barrington's District 4
BARRINGTON — Four candidates for state representative are running for two open seats in District 4, which consists of Barrington.


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Anti-Nuclear protest in Tokyo
Anti Nuke protest outside Prime Ministers House, Tokyo
A protest flag flies in front of the Diet Building as several thousand people gather outside the Prime Minister's house and in front of the Diet building in Tokyo to protest against nuclear power. Nagatacho Tokyo, Japan. Friday August 10th 2012. Protests have been held every Friday from 6pm to 8pm since March 2012 and participants have been growing in number as Prime Minister Noda carries out his policies of restarting Japan's nuclear reactors. All japan's nuclear reactors were shut down for...
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PET Clinics
As the clinical applications of positron emission tomography (PET) increase, PET Clinics brings together the combined expertise of leading authorities in the field to provide you incisive clinical reviews on advances in the use of PET. Published quarterly (January, April, July, and October), PET Clinics examines this technology's effectiveness in cancer diagnosis and staging, as well as exploring PET's usefulness in the areas of dementia, myocardial viability, and other conditions. Full-color images featured throughout. Topics include breast cancer, Alzheimer's disease and dementia, lymphoma, lung cancer, cardiology, pediatric applications, infection and inflammation, as well as oncologic imaging, neurologic imaging, cardiac imaging, pediatric imaging, PET/CT imaging, and PET/MRI imaging. In addition, you can also purchase a CME subscription that offers up to 60 AMA Category 1 credits per year.
Consulting Editor Abass Alavi, MD
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