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Impact of Sequestration on the NIH – Fact SheetThursday June 6, 2013 | by Barb Gardner | Category: News
On March 1, 2013, as required by statute, President Obama signed an order initiating sequestration. The sequestration requires NIH to cut 5 percent or $1.55 billion of its fiscal year (FY) 2013 budget. NIH must apply the cut evenly across all programs, projects, and activities (PPAs), which are primarily NIH institutes and centers. This means every area of medical research will be affected.
The estimated numbers:
(FY 2013 figures compared to FY 2012. While much of these decreases are due to sequester, NIH funding is always a dynamic situation with multiple drivers:)
Approximately 700 fewer competitive research project grants issued
Approximately 750 fewer new patients admitted to the NIH Clinical Center
No increase in stipends for National Research Service Award recipients in FY2013
The impact:
Delay in medical progress:
Medical breakthroughs do not happen overnight. In almost all instances, breakthrough discoveries result from years of incremental research to understand how disease starts and progresses.
Even after the cause and potential drug target of a disease is discovered, it takes on average 13 years and $1 billion to develop a treatment for that target.
Therefore, cuts to research are delaying progress in medical breakthroughs, including:
development of better cancer drugs that zero in on a tumor with fewer side effects
research on a universal flu vaccine that could fight every strain of influenza without needing a yearly shot.
prevention of debilitating chronic conditions that are costly to society and delay development of more effective treatments for common and rare diseases affecting millions of Americans.
Risk to scientific workforce:
NIH drives job creation and economic growth. NIH research funding directly supports hundreds of thousands of American jobs and serves as a foundation for the medical innovation sector, which employs 1 million U.S. citizens. Cuts to NIH funding will have an economic impact in communities throughout the U.S. For every six applications submitted to the NIH, only one will be funded. Sequestration is reducing the overall funding available for grants. See the history of NIH funding success rates.
Frequently asked questions:
- How many fewer grants will be awarded?
Approximately 700 fewer research project grants compared to FY 2012.
- Have the institutes and centers announced their adjusted paylines based on these cuts?
The adjusted NIH Institute and Center (IC) paylines and funding strategies can be found here: http://grants.nih.gov/grants/financial/index.htm#strategies
- What percent cut will be made to existing grants?
Reductions to noncompeting research project grants (RPG) vary depending on the circumstances of the particular IC. The NIH-wide average is -4.7 percent.
- Will the duration of existing grants be shortened to accommodate the cuts?
In general, no.
- Will all grants receive the same percentage cut or will some grants be cut more than others?
Institutes and centers have flexibility to accommodate the new budget level in a fashion that allows them to meet their scientific and strategic goals. As noted above, there are different percentages for different ICs, and in some cases for different mechanisms within an IC (RPGs, Centers, etc.). In addition, there may be reductions to grants for reasons other than sequestration, as is the case every year.
- Will certain areas of science that are at a critical juncture be affected by these cuts?
All areas of science are expected to be affected.
- Will some areas of science be affected more than others?
The sequester does not stipulate the precise reduction to each scientific area. However, it is likely that most scientific areas will be reduced by about 5 percent because the sequester is being applied broadly at the NIH institute and center level.
- What will be the impact of these cuts to NIH's intramural research at its Bethesda campus and off-campus facilities?
The impact on NIH's intramural research is substantial, especially because it applies retroactively to spending since Oct. 1, 2012. That can double the effect — a full year's cut has to be absorbed in less than half a year.
- Will NIH be furloughing or cutting employees at its NIH campus and off-campus facilities?
There are no current plans to do so. At present, HHS is pursuing non-furlough administrative cost savings such as delayed/forgone hiring and reducing administrative services contracts so that furloughs and layoffs can be avoided. Additionally, employee salaries at NIH make up a very small percentage (only 7 percent) of the NIH budget.
- How will current patients at the NIH Clinical Center be affected?
Services to patients will not be reduced.
- Will the NIH Clinical Center see fewer patients because of the cuts?
Approximately 750 fewer new patients will be admitted to the NIH Clinical Center hospital in 2013 or a decrease from 10,695 new patients in 2012 to approximately 9,945 new patients in 2013. While much of this decrease is due to funding, clinical activity is always a dynamic situation with multiple drivers.
- Will the sequester cut need to be applied to the FY 2014 budget?
The President's FY 2014 Budget would replace sequestration and reduce the deficit in a balanced way. The President is ready to work with Congress to further reduce deficits while continuing to make critical investments.
Full article can be found at: http://www.nih.gov/news/health/jun2013/nih-03.htm


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BELVIDERE (WIFR) -- On Tuesday, February 5, 2013 the Belvidere Police Department arrested a woman on multiple drug charges after receiving neighborhood complaints.
27-year-old Sheena Kesler, of Belvidere, IL, was charged with one count of unlawful delivery of a controlled substance within 1000 feet of a senior citizen complex (cocaine – class x felony), one count of unlawful delivery of a controlled substance (cocaine – class 1 felony) and two counts of endangering the life or health of a child. Kesler is currently being held in the Boone County Jail on a $100,000.00 (10%) bond.
Kesler's arrest concluded a two month investigation by the Narcotics Unit of the Belvidere Police. Kesler allegedly sold cocaine to undercover officers while her two children, both under the age of eight, were present.
Kelsler was taken into custody on February 5th at a residence located in the 500 block of West Hurlbut Avenue, Belvidere. When detectives searched the residence, they seized cannabis, scales, drug packaging material, drug paraphernalia, U.S. currency and a vehicle. The children were also taken into protective custody and later turned over to the Department of Children and Family Services.
The investigation began after police received numerous complaints from area residents who reside in the 500 block of West Hurlbut Avenue. The arrest is another example of residents taking stock in their neighborhood and calling police. This partnership between the residents and the police department continue to help make Belvidere a safer community.
A Class X felony is punishable by 6-30 years in the Department of Corrections. A class 1 felony is punishable by 4-15 years in the department of corrections.

subset: commoncrawl


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Discussions about eggcorns and related topics
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Registrations are currently closed because of a technical problem. Please send email to
The forum administrator reserves the right to request users to plausibly demonstrate that they are real people with an interest in the topic of eggcorns. Otherwise they may be removed with no further justification. Likewise, accounts that have not been used for posting may be removed.
Thanks for your understanding.
Chris -- 2018-04-11
jorkel wrote:
I would break item D out into two separate thoughts (somehow).
. The eggcorn introduces a unique set of imagery,
and second
. The eggcorn applies in the context of the original.
I think we have to be careful to not connect the eggcorn too closely to the meaning of the original. We should tiptoe around the issue by using the word "context". I make the distinction because the utterer is only aware of the context in which the original is used, but may never understand the true meaning of the original.
Remark added after posting the above:
I just noticed that "context" is mentioned in item B.
Perhaps item D just needs a little more wordsmithing.
Last edited by jorkel (Today 11:00:58)
Last edited by DavidTuggy (2008-06-27 19:21:43)
*If the human mind were simple enough for us to understand,
we would be too simple-minded to understand it* .
For reference, D. reads
Perhaps most importantly, the eggcorn should introduce a new set of imagery that seems to refer on some level to the meaning of the original word.
I think I see where you're coming from, jorkel.
It seems right that, as you say, context is key when talking about the meaning match of the original and the eggcorn. Indeed, by definition, the eggcorn is a departure from the compositional meaning of the original, so we not only don't want to, we can't demand identity of meaning. So I think criterion B. gets that right. (A-D are all Pat's wording, not mine, fwtw.)
Context is key precisely because that's what we figure meanings out from in the first place. If two meanings always work in each other's place, that's good enough to communicate with. It's always fun when you can get some context where they don't work and you suddenly realize you've been miscommunicating for a while.
I think part of the problem may be in the word "refer" in criterion D. I'd rather it said "connects in interesting and/or reasonable ways to" or "can be seen as contributing on some level to something like" the original meaning. "Refer to" too often means "designate", and that doesn't work here.
Last edited by DavidTuggy (2008-06-27 19:22:58)
*If the human mind were simple enough for us to understand,
we would be too simple-minded to understand it* .
Another copied comment: from patschweiterman
JOrkel wrote
I think we have to be careful to not connect the eggcorn too closely to the meaning of the original.
What confusions might the use of the word "meaning" introduce? This isn't at all clear to me. True, the people committing the eggcorns probably don't know the original word—or they wouldn't be eggcorning. But it only makes sense to me to try and define the term "eggcorn" from the perspective of the person comparing a reshaping to its original—and not from the perspective of the eggcorner. Also, both "context" and "apply" seem to me too vague and general. I don't think attempting to avoid the word "meaning" when defining "eggcorn" is a good idea.
*If the human mind were simple enough for us to understand,
we would be too simple-minded to understand it* .
As we break the various criteria out into separate threads, it might be useful to keep a list of inter-links posted in the very first post in each thread. Whoever writes that first post could add new links as they show up. I'm already getting whiplash just switching between the two threads we've got going now—since a good deal of the two is currently shared material, it's easy to get lost.


text:
"Search Document Records - Juanita Stinette Chappelle Results "
Viewing 1 to 3 of 3
Vocal Blues & Jazz Vol 3 1921 - 1928
Genres: Blues, Classic Blues, Female Blues Vocal, Jazz.
Volume three of this three volume series presents an interesting selection of blues influenced popular and vaudeville tunes of the day. At the time of this CDs production most of the recordings were not included in the collectors Bible 'Blues and Gospel Records' which is regarded by many as a comprehensive discography.
The range of subject matter across these tracks covers many aspects of every day life but the main theme is love; Cora Green and Hamtree Harrington's trade insults with comedy dialogue on If I Can't Get In and Marjorie Royce uses her full bodied voice on the humorous My Daddy's Growin' Old. Gertrude Dwyer delivers her suggestive material with panache... Continued...
More Info on our New Store >>
Female Blues Singers Vol 4 C 1921 - 1930
DOCD-5508 Female Blues Singers Vol 4 C 1921 � 1930 Genres: Blues, Classic Blues, Female Blues, Jazz. Informative booklet notes by David Evans Detailed discography. The majority of tracks on this volume are sung in a dramatic style. This style is heard often in the very early 1920s but was pretty much pass� by 1923. Some of the characteristics of the style of the early recordings may be due to the fact that these records were aimed at both white and black customers. The collection is made all the more interesting with the appearance of some fine jazz accompanists including James P. Johnson, Bob Fuller, Louis Hooper and Buddy Christian. The female blues singers who made records in the 1920s and early 1930 are often simplistically characterized as "vaudeville" artists. This series of fourteen, concentrating on singers who made only a handful of recordings and who mostly remain biographically obscure, reveals the true diversity of the female artists of this era. Continued...
More Info on our New Store >>
Too Late Too Late Vol 13 1921 - 1940
More Info on our New Store >>


text:
next set of answer suggestions from JWW..
1 I had fine omens, O men, when offering sacrifices
2 it is now possible, for those who have been saved to proceed
or (?) it is now possible, since they have been saved, for them to proceed
3 although they feared the way, they followed
4 let us send men who will capture the heights
5 although they alone had been left behind, they were beyond the reach of those cutting down the watch/garrison
6 and he was waging war out of the Chersonese, setting forth to(wards) the Thracians who live(d) beyond the Hellespont
7 being most especially honoured at that time by Cyrus, he now tries to do us, the friends of Cyrus, evil
8 the mother, after having begged-him-off/gained-his-release, sends (?him) off again to the province
9 because of what wrong that you have suffered through me, said Cyrus, do you now plan against me?
Cyrus arrests Orontas, and calls together seven Persians from his staff to his own tent, and he ordered the Greek generals to bring the hoplites, these having been drawn up around his tent. These things they did, bringing about three thousand hoplites. He summoned Clearchus inside also (as) advisor; for this man, both by him and by the others, appears to have been most especially honoured of the Greeks.
1 the man is a friend worth-much/worthy-of-much
2 and a great and flourishing city was situated there
3 great/much was the fear of the barbarians (that they felt)
4 they began to encamp near to a large and fine park
5 he was sending Cyrus many things for his army
6 at the middle of this day's march, was a deep trench
7 he had many of the guards behind the beasts of burden
8 in this place/here is a spring of sweet water
9 he proceeded to the river, which had a width of one plethron, and (was) full of large fish
10 he had the half of the army
[face=SPIonic]a. o9 oi]no/j e0sti pa/nu h9du/j
b. au0to/qi tw|~ Ku/rw| h]san basi/leia kai\ para/deisoj m/egaj
g. oi9 stratiw~tai e0n e0lpi/si mega/laij h]san
d. e0nteu/qen e0poreu/onto ei0j to\ pedi/on me/ga kai\ kalo/n
e. e0n tou~to to\ pedi/on kw/mai pollai\ h]san[/face]
After the judgement of Orontas, Clearchus reported how it was conducted to his friends; for it was not a secret. He said that Cyrus began his speech as follows: "I called you, (my) men, friends, how to do-right/act-justly – both before God and before men – concerning this Orontas, after discussing (it) with you. For at first my father gave him to be-obedient-to/serve me; then having arranged, as he says by my brother, he makes war on me, having the citadel in Sardis, and warring against him, I made him stop the war against me."
1 he encircled Miletus with his ships
2 in the/their houses were oxen and birds
3 the interpreter says that they come from the great King of Persia to Cyrus
4 there was also present a certain Spartan general on the ships
5 if the King of Persian were to encamp on the plain, the cavalry would arm
6 the interpreter came towards the altar of Artemis
7 on account of this Cyrus, called for the/his ships
8 they left behind the old men and (old) women
9 and from (the side of) the great King, arrived Tissaphernes and the brother of the King's wife
10 did not therefore many desert the King for Cyrus, since they became enemies of each-other/to-one-another?
[face=SPIonic]a. toi~j tw~n 9Ellh/nwn strathgoi~j e1pemye to\n e9rmhne/a
b. diarpa/swmen th\n basile/wj xw/ran
g. basile/a bou=j h1|thsan
d. para\ basile/a me/gan e1stai h9 o9do/j
e. Ku=roj ga\r tw~| basilei~ e1pemye tou\j tw~n po/lewn dasmou/j[/face]
After these things, he said, "O Orontas, what wrong did I do you?" he answered that he had done nothing wrong. Again Cyrus asks, "Did you not then, the next day, as you yourself confess not being wronged against, treat my country badly?" Orontas said (yes). "Did you not then, when again you understood your own power, come to the altar of Artemis and persuade me, and again gave me pledges, and received (so) from me?" – and Orontas confessed these (were true).[face=Arial][/face]


text:
Did you read today's front page stories & breaking news?
From the Wires
Secure Files Services and Google Apps Support Business Growth for Merrimack Mortgage Company
By: PR Newswire
Dec. 26, 2012 01:01 PM
WESTBOROUGH, Mass., Dec. 26, 2012 /PRNewswire/ -- As one of the largest independent mortgage bankers in the Northeast, Merrimack Mortgage Company (MMC) continues to lead the market. With continued, exceptional growth, MMC's IT department must bring new loan officers and locations online quickly and effectively.
As a key component of their strategic plan, MMC chose Google Apps for Business for its integrated communication and file services. Enabling greater information sharing across existing and new offices, Google Apps also creates a consistent environment that meets governance and audit requirements.
"The business side of me saw Google Apps as a slam dunk from a ROI and TCO perspective, and the technologist in me also couldn't argue against introducing variable costs, scalability, availability, and OS and hardware independence," noted Matthew Seaton, CIO of Merrimack Mortgage Company. Cumulus Global recommended and helped us deploy CloudLock and Backupify for compliance, policy enforcement, risk mitigation, and data protection. This allowed us to fully embrace Google Apps and made both my Chief Compliance Officer and CFO very happy."
Integrating Google Apps and CloudLock, Merrimack Mortgage Company extends its security perimeter to the cloud. MMC ensures its use of email, calendars, contacts, and files stored and shared via Google Drive comply with regulations like SOX, GLBA, and ISO, as well as internal policies. Backupify protects data across Google Apps accounts against data damage or deletion due to user error.
"I am not sure if I would have felt confident with my decision to move our company's communication and collaboration needs to Google Apps for Business without the solutions and assistance from Cumulus Global. The integrated solution has relieved my anxiety over having our company data hosted by a third party," said Seaton. "Our management team was relieved by the value proposition. We pay as we grow rather than making large up-front capital investments."
Since MMC's initial Google Apps for Business implementation in June of 2011, MMC has increased sales staff by 15% and the number of physical locations by 26%. Operations staff increases have been minimal in comparison. The greatest benefit, in regards to increased sales staffing and locations, is the ability turn-up new team members literally in minutes. In more recent months, MMC has seen back-to-back monthly company record breaking sales numbers.
To learn more about Merrimack Mortgage Company, visit: http://www.merrimackmortgage.com.
About Cumulus Global
Cumulus Global (http://www.cumulusglobal.com) is Cloud Solutions Provider and a Google Apps Premier SMB Reseller helping small and mid-size businesses, non-profits, governments, and schools move to cloud computing solutions. Cumulus Global also offers a range of cloud-based security, storage, and server solutions.
CONTACT: Allen Falcon, 1-508-948-4071, email@example.com
SOURCE Cumulus Global
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text:
Microtel Inns Suttons Bay hotels are listed below. Search for cheap and discount Microtel Inns hotel rates in Suttons Bay, MI for your upcoming individual or group travel. We list the best Microtel Inns Suttons Bay hotels & lodging so you can review the Suttons Bay Microtel Inns hotel list below to find the perfect place.
This page will also provide Suttons Bay, MI hotels/properties that have a comparable rating of a Microtel Inns.
Booking a group or meeting? Set up a group hotel block in Suttons Bay MI


text:
PMR heads for areal density limit
Industry dithers over what's next
Current perpendicular magnetic recording (PMR) for hard drives is going to reach its areal density limit, and it looks like the industry has not yet decided on which candidate technology is going to replace it.
PMR reaches its limit when the magnetised area is so small its north or south pole state can be flipped by random heat fluctuations and changing the recording layer's chemistry to prevent that makes it much harder to write and read bits. There are two ways around this.
Heat-assisted magnetic recoding (HAMR) says go with the changed chemistry and heat the bit before writing data so that it is, temporarily, easier to change its magnetic state. It means adding a laser heating element to the write head.
The other way is to use existing recording media chemistry more or less but add an insulating ring around the bit so that it becomes relatively more impervious to heat-induced changes or other influences from the surrounding media layer. This is called bit-patterned media (BPM) and las an allied technology to layout tracks more precisely called discrete track recording (DTR).
It appears Seagate is more in favour at this stage of HAMR, whereas other suppliers are not so partial.
Steve Pereira, the EMEA head for Hitachi GST, says his company is looking at both BPM and HAMR possibilities and hasn't decided which to choose yet.
In conversations with Stifel Nicolaus analyst Aaron Rakers, Xyratex, which makes test equipment for hard disk drive suppliers, has said it sees a 2-year roadmap to 800Gbit/sq in with PMR, which is currently passing the 500Gbit/sq in level. That would roughly mean that today's 500GB capacity hard drive would then hold 800GB and a 3.5-inch 4-platter 2TB drive would store 3.6TB. After 800Gbit/sq in a change to either BPM or HAMR is needed to push areal density further and increase platter capacity.
Xyratex sees a post-PMR technology coming into place in the 2014/2015 period. Currently it is seeing a 60 per cent compound annual growth rate (CAGR) in storage HDD areal density, but this will slow to 20 per cent CAGR in the 2011/2012 period. ®
Sponsored: Minds Mastering Machines - Call for papers now open


text:
2013: A Year Of Huge Shifts For The Storage Industry
The storage industry went through a series of major upheavals in 2013.
It was a year in which we saw the rise of software-defined storage and the fall of storage hardware sales, growth in cloud storage and the death of cloud storage providers, and a massive rush to grab mind share in flash storage even as the flash storage industry started its inevitable consolidation.
CRN was there watching it all unfold. Turn the page to see just how interesting a year it was with a look at all the key trends and key players in storage in 2013.


text:
Gallery: 7 Best Types of Holiday Candy
The holidays might be over, such as they are, for November and December. But January marks the beginning of the best candy season — and I know this because I just finished savoring my first Cadbury egg of the year. It's a good day, ladies, and there will be many, many more.
Here are some other holiday candy favorites:[ITPGallery]


text:
Cancer Survivor and World War II Veteran Tom Mastin to Speak About the "Positive Side" of Cancer at UH Manoa
Mastin to participate in part II ofUniversity of Hawaiʻi
Kristen Cabral, (808) 956-5039
Public Information Officer
HONOLULU — The University of Hawaiʻi at Mānoa's Counseling and Student Development Center (CSDC) and Campus Center Meetings & Events Services presents part II of the "UH Breaking Bread Together to Make a Difference Speakers Series" with an inspirational talk by guest speaker Tom Mastin. The event will be held on Monday, November 17, from 8:30 a.m. to 1:30 p.m. at the UH Mānoa Campus Center (Rooms 306, 307, and 308).
A World War II Veteran, Mastin has survived three different types of cancer over the last three decades and is now a volunteer for the American Cancer Society where he works to increase awareness about the various aspects of terminal illness. He helped start and is a member of two support groups for cancer patients and their familiesUS TOO!, a support group for men with prostate cancer, and Make Today Count, a support group for people with cancer and other life threatening diseases and their families.
The "UH Breaking Bread Together to Make a Difference Speakers Series" was established to provide opportunities for self-improvement and to create an atmosphere of positivism at the UH Mānoa campus and throughout the larger island community.
For more information about the event and to register, contact Dr. Michi Fu at (808) 956-7927. There is a registration fee of $15, which includes lunch.


text:
SYS-CON.TV Webcasts
Did you read today's front page stories & breaking news?
Top Links You Must Click On
From the Wires
TCL Multimedia Makes Breakthrough with its Annual LCD TV Sales Volume Exceeding 15 Million Sets
Achieves Success in the PRC TV Industry
By: PR Newswire
Dec. 18, 2012 09:24 AM
HONG KONG, Dec. 18, 2012 /PRNewswire/ -- TCL Multimedia Technology Holdings Limited ("TCL Multimedia" or "the Group", HKSE stock code: 01070) is pleased to announce that its annual LCD TV sales volume exceeded 15 million sets as at 18 December 2012, marking the first time a Chinese TV manufacturer has reached 15 million sets in annual sales volume, a significant milestone in the development of the PRC TV industry. Meanwhile, the Group remains optimistic about the prospects for the PRC's TV industry and its business development, and is confident that it will achieve its 2012 LCD TV sales target of 15.2 million sets.
According to the latest DisplaySearch report, as of the third quarter in 2012, the Group's global LCD TV market share increased to 6.7% in the third quarter of 2012 from 5.0% in the second quarter of 2012, bringing its ranking up to No. 4 and marking the first time a Chinese television manufacturer has been ranked among the top four global LCD TV makers by market share. The Group has also maintained its No.1 position in the PRC LCD TV Market with a market share of 18.7%.
TCL Multimedia successfully secured its leadership in the TV market by virtue of putting a focus on "speed and efficiency" in its operational and marketing strategies, and to its dedication to the optimization of its product mix and sales channels. Having not only pioneered the "full cloud strategies" and announced a number of smart "cloud" products in April 2012, the Group also jointly launched with Tencent Holdings the iCE SCREEN, the world's first large screen mobile entertainment smart "cloud" product, creating a new form of consumer electronics product. This innovative cross-industry integration model has also set a new benchmark in innovation in the consumer electronics industry and internet industry in the PRC. In 2012, the Group signed a strategic cooperation agreement with a number of home appliance chain stores, including Suning Appliance, to further expand its emerging and traditional channels such as online shopping, making a leap in the PRC market. In the first three quarters of 2012, the sales volume of LCD TVs in the Overseas Markets increased by 75.97% year-on-year to 4.878 million sets.
In addition, with a brand value of RMB58,326 million, TCL maintained the top TV brand in China for the seventh year in a row in the "Most Valuable Chinese Brands Evaluation", co-organized by R&F Global Ranking Information Group Ltd. and Beijing Famous Brand Evaluation Co., Ltd. Apart from establishing a strategic partnership with the Hollywood film "Cloud Altas", TCL was also ranked among the "Global Competitiveness Brands -- Top 10 from China" for the third consecutive year.
In addition to pursuing its "full cloud strategies", TCL Multimedia continues to cement the layout of its strategies in the global market, to accelerate the development of innovative technology, optimize its product mix and take full advantage of vertical integration in order to enhance its core competitiveness. In the meantime, TCL Multimedia continues to increase its brand influence in the worldwide by taking advantage of its multi-brand strategy.
About TCL Multimedia
TCL Multimedia Technology Holdings Limited (stock code: 01070.HK) headquartered in China, is one of the leading players in the global TV industry. TCL Multimedia is engaged in the R&D, manufacture and distribution of consumer electronic products comprising television and audio visual products. Its ultimate shareholder is TCL Corporation. For more information, please visit its website: http://multimedia.tcl.com.
Investor & Media Inquiries
For further enquiries, please contact Hill +Knowlton Strategies Asia:
SOURCE TCL Multimedia Technology Holdings Limited
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text:
Jersey Shore 10 p.m., MTV
Please sit down. This will come as very sad news. Thursday night, "Jersey Shore" is ending its six-season run. The show peaked with about 9 million viewers, which is a lot bigger than the audiences for "Mad Men" or "Homeland." Oh sure, Snooki (left) and her pals will continue to appear all over cable TV, or you may run into them at the tanning salon; but their group adventure is over. Don't fret, though. Civilization-ending programming will continue, from the Kardashians and from TLC, which brings us "Here Comes Honey Boo Boo" and "Toddlers & Tiaras."
A White House Christmas: First Families Remember 8 p.m.,
Channel 7
It's a First-fest, hosted by Meredith Vieira. First lady Michelle Obama and former first ladies Laura Bush, Hillary Clinton, Barbara Bush, and Rosalynn Carter recall celebrating the holidays in the White House. Also adding their perspectives: former first children Jenna Bush Hager, Chelsea Clinton, Dorothy Bush Koch, Michael Reagan, Amy Carter, Susan Ford Bales, Tricia Nixon Cox, Julie Nixon Eisenhower, Lynda Johnson Robb, and Luci Baines Johnson.
2012: The End Is Now 9 p.m., History Channel
We're on the eve of destruction.
CMA Country Christmas 9 p.m., Channel 5
Martina and Dierks, but no Reba? I call Orangephobia.
Late Show With David Letterman 11:35 p.m., Channel 4
Katie Holmes talks about living in a shopping-trip loop.Matthew Gilbert can be reached at firstname.lastname@example.com. Follow him on Twitter @MatthewGilbert.


text:
Hoge Fenton Jones & Appel is pleased to announce that former shareholder James
E. Towery has been appointed by Governor Brown to serve on the bench
in the Superior Court of California, County of Santa Clara, with
swearing-in expected in December.
James E. Towery (Photo: Business Wire)
Towery, a renowned expert in legal ethics, has a decades-long history of
commitment to the legal profession. He recently served as Chief Trial
Counsel to the State Bar of California, was President of the State Bar
in 1995-96, chaired the Board of Governors Discipline Committee in 1994,
served on the California Chief Justice's Commission on
Multi-Jurisdictional Practice, and chaired its Task Force on Insurance
Disclosure. In 2008 he was selected as a Lawyer Representative to the
federal Ninth Circuit Judicial Conference. Towery also served in the
American Bar Association House ofDelegates for many years and has been
selected to the American Board of Trial Advocates.
In his 21 years at Hoge Fenton, Towery demonstrated a similar commitment
to leadership, serving on the firm's Executive Committee, acting as its
risk management counsel, and chairing its litigation practice group. He
acted as a mentor to young litigators and was instrumental in ensuring
that the firm's associates were afforded a high level of ongoing
training in trial advocacy skills.
Daniel W. Ballesteros, a shareholder and member of Hoge Fenton's
Executive Committee, commented, "Jim exemplifies Hoge Fenton's
commitment to the legal profession and to serving our community. He
joins a very distinguished class of Hoge Fenton alumni who have been so
honored to serve, and we could not be more proud of his appointment. We
wish him the very best in this next phase of his career."
Towery said, "I have been blessed during my career to work with some
outstanding trial lawyers and wonderful colleagues, such as those at
Hoge Fenton as well as my present firm of Rossi Hamerslough. Both firms
have a real commitment to public service which I greatly value."
About Hoge Fenton:
For many clients, we are the smart alternative to "big law." We are a
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RENO, Nev. It can happen at any time; as you walk to your car after work or in the middle of the night in your own home. Without notice, you can be approached by a person who wants to harm you.
"Women are statistically more vulnerable, or targeted more often than men are," Jay Hawkins, an instructor at U.S. Firearms Academy in Reno, said.
Which is why Hawkins, along with U.S. Firearms Academy co-owner Debbie Block are hosting two women's only 'Draw from Concealment' classes on August 7 and 8.
The goal is to make more women comfortable drawing their weapons and using them appropriately.
"Many people think, if I take a CCW class or purchase a fire arm- or any defensive tool- and throw it in my purse, that when I need it I'm just going to grab it and go," Hawkins said. "But that's not how it works."
Hawkins said it's important for women to have their hands on their gun, or defensive weapon of choice, while walking.
But knowing you can quickly pull out your gun or Taser when you need it is only half the battle.
"We do lose a lot of motor skills under stress," Block said. "So one of the things I wanted as an everyday person was to train under some stressful situations."
Just a few doors down from U.S. Firearm Academy's main store is a class room like setting. A few chairs circle around a video screen, and throughout the room, a few barriers are placed.
It's called MiScenario. It's a virtual tool used to place women in actual situations where they would have to draw, and possibly use, their weapon.
"We want to train you more in that environment you expect to perform in," Hawkins said.
Using a real gun converted to use air compression and sensors, women are placed in front of programmed scenarios where they have to react quickly and decided if they should fire.
Each scenario can be custom programmed, so you may never see the same one twice.
It may look like a video game, in fact many of the scenarios have an animated quality. But others, will take you by surprise.
"We want to open their eyes to 'these are your options, now let's see how you use them,'" Hawkins said.
The classes will be held Wednesday August 7th from 9-10 am and Thursday August 8th from 6-7 pm. Each class costs $50 and is limited to six women. You are asked to bring your own weapon and method of concealment if you have one. For more information or to sign up, call U.S. Firearms Academy at 826-2626.


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HIV JournalView
June 2004
Table of Contents
Resistance (to Resistance Testing of the Treatment-Naive) Is Futile
Many already do and if you don't now, you will. Testing for drug-resistant HIV among treatment-naive patients, once thought to be an exercise in futility, is becoming commonplace. This follows several studies from the United States and Europe demonstrating that a significant proportion of such patients harbors detectable levels of drug-resistant virus.1-3
The transmission of HIV that has reduced susceptibility to antiretrovirals has been well described and resistance testing of patients with acute HIV infection has become standard practice.4-11 Until recently, the dominant paradigm held that following primary HIV infection, in the absence of drug selection pressure, the relatively fitter "wild-type" virus would overgrow resistant variants and only wild type virus would be sampled during subsequent resistance testing. However, several recent studies of cohorts of chronically infected individuals have challenged the conventional thinking regarding the detection of drug resistance and have revealed that certain resistance mutations can persist for much longer than previously believed.1,12
The results of 2 studies focusing on the prevalence of drug resistance among HIV-infected persons, previously presented during conferences, were published this month and are described below. Although they examine different but overlapping patient populations, both studies add to an emerging picture of resistance rates among patients in clinical care.
Richman DD, Morton SC, Wrin T, et al. The prevalence of antiretroviral drug resistance in the United States. AIDS. July 2, 2004;18(10):1393-1401.
To estimate the prevalence of drug resistance among persons with HIV in the United States during the years following the availability of highly active antiretroviral therapy (HAART), investigators of the HIV Cost and Service Utilization Study (HCSUS) examined phenotypic resistance patterns in study participants who had received care in 1996 and survived at least until 1998 when their blood was drawn during the study.
HCSUS is a large cohort study comprised of HIV-infected persons under care in urban clinics nationwide. Its participants are considered to be representative of persons with HIV infection in the United States. Therefore, HCSUS investigators frequently extend the findings from their sample to the population of HIV-infected persons at large. The 2,864 study participants thus represent 231,000 individuals under HIV care in the contiguous United States, which makes for some impressive-sounding results although it should remain clear that 231,000 people did not actually participate in the study.
Among the cohort, 1,797 of the original 2,864 participants had survived from 1996 to 1998; of these, 1,099 had a viral load >500 copies/mL and phenotypic drug resistance testing results available. Among the 1,099 subjects, 76% had evidence of resistance by phenotype to 1 or more antiretrovirals.
Broken down by drug class, the rates of resistance were 71% for nucleotide/nucleoside reverse transcriptase inhibitors (NRTIs), 41% for protease inhibitors (PIs) and 25% for non-nucleoside reverse transcriptase inhibitors (NNRTIs). Lamivudine (3TC, Epivir) was the agent for which there was the highest rate of resistance (68%), which is not unexpected given the low resistance barrier of this ubiquitous antiretroviral. Almost half (48%) of the viremic subjects had multiple-class resistance, with 13% having resistance to all 3 drug classes. Extrapolating to the larger population, the investigators estimated that over 100,000 HIV-infected persons with a viral load >500 copies/mL have detectable drug resistance.
Several factors were identified as being associated with resistance, including, as can be expected, the use of HIV therapy and NRTIs in 1996, when the HAART era began. Not surprisingly, current use of antiretroviral therapy was associated with drug resistance among the patients with a detectable viral load, as was a higher current viral load, lowest self-reported CD4+ cell count and advanced disease stage.
Germane to the argument regarding resistance testing among patients not on HIV therapy, 30% of the participants who were not receiving antiretrovirals had evidence of drug resistance (22% for NRTIs, 11% for NNRTIs and 11% for PIs) and 11% were resistant to agents in 2 drug classes. Of the patients who had never been on an antiretroviral, 10.9% had drug resistance and almost all of these cases were due to NNRTI resistance (9.3%).
These data are interesting in a number of ways. Foremost, the characterization of the HCSUS cohort permits a quantitative reflection of how people with HIV currently in treatment, in general, are doing. A majority of the cohort (63%) had detectable viremia and, of these, 80% were receiving antiretrovirals. The finding that drug resistance was prevalent among those with viremia comes as little surprise to those of us who see patients, because patients with detectable viral loads who are on therapy are generally expected to have drug resistance. The high rates, however, are sobering and point to the need for thoughtful use of HIV therapy, including the need to properly balance potency, tolerability, salvage options and convenience, as well as the need for new agents that are effective against resistant variants. Fortunately, since the study period (1996-1998), HIV therapy has evolved and is arguably more potent and convenient.
In fact, data from on-going studies indicate that resistance rates among recently infected persons are actually starting to decline, presumably since improved therapeutics have led to a decrease in viremia and, therefore, reduced rates of transmission of resistant HIV by those on therapy.13,14
Potential for Transmission of Drug-Resistant Virus
That said, the potential for viremic patients with drug-resistant variants to transmit drug-resistant virus to others remains a concern and, although not a focus of this particular report, these data do illustrate the degree to which drug resistance can be detected even among patients naive to HIV therapy -- findings that are consistent with other studies.1,15-17
The resistance seen in treatment-naive patients is likely to be the tip of the proverbial iceberg, as NNRTI-associated mutations have less impact on viral fitness and, therefore, are relatively more stable than mutations associated with other treatment classes. These other mutations may not persist in sufficient quantities following infection to be detected by resistance testing, even though the resistant strains remain archived in some infected cells and can become dominant under treatment selection pressure. Also, this study was not able to assess the presence of resistant virus among patients with viral loads <500 copies/mL who may have acquired resistant virus at the time of infection but had too few circulating virus for resistance testing to be performed.
These results support resistance testing among treatment-naive patients -- particularly given the current reliance on NNRTIs as initial HIV therapy. The detection of NNRTI resistance in an individual naive to treatment and about to start an antiretroviral regimen would steer most clinicians away from prescribing an NNRTI. But, even if therapy is not being considered at the time of presentation to clinic, resistance testing can be useful to document any resistance that is present and may wane with time. Therefore, it is this author's opinion that this study, the study below and those referenced, support resistance testing of persons naive to HIV therapy, regardless of duration of HIV infection.
Weinstock HS, Zaidi I, Heneine W, et al. The epidemiology of antiretroviral drug resistance among drug-naive HIV-1-infected persons in 10 US cities. J Infect Dis. June 15, 2004;189(12):2174-2180.
Similar to the HCSUS study, this Centers for Disease Control and Prevention (CDC) investigation aimed to characterize antiretroviral resistance in urban populations in the United States. However, unlike HCSUS, the CDC study enrolled only patients naive to therapy. The study was conducted between 1997 and 2001 in 39 clinics in 10 cities: San Francisco, San Diego, Denver, Detroit, Grand Rapids, Houston, New York, Newark, New Orleans and Miami. A total of 1,104 adult patients were enrolled, of whom 1,082 had genotypic resistance assays successfully performed. Three quarters of the participants were male, 73% were non-white and 60% were men who have sex with men. Approximately 19% were determined to be recently HIV infected (within the prior 4-6 months) using a de-tuned antibody assay.
Men Who Have Sex With Men Most Likely to Have Drug Resistance
Not dissimilar to the HCSUS results, overall, 8.3% (90 patients) of the cohort harbored mutations detected by genotypic resistance testing. The breakdown of the prevalence of resistance mutations by antiretroviral class was 6.4% for NRTIs, 1.9% for PIs and 1.7% for NNRTIs. Only 1.3% had evidence of drug resistance to 2 or more antiretrovirals. Men who have sex with men were more likely to have resistance mutations than women and heterosexual men (12% versus 6.1% and 4.7%, respectively). Likewise, whites had higher rates of resistance (13%) compared to African-Americans (5.4%) and Hispanics (7.9%). These demographic factors are likely to be indicators of access to HIV care as groups with relatively less exposure to antiretrovirals have fewer opportunities to develop resistance to transmit to others.
The most commonly observed NRTI-associated mutations were M41L (19 patients), K70R (9 patients), M184V (9 patients) and D67N (7 patients). However, 27 patients had one of the T215D/S/C/E/I mutations; these are mutants of the 215 codon that have back-mutated from the thymidine analogue mutation T215Y and which can revert back to T215Y under treatment pressure. K103N was the predominant NNRTI mutation and L90M the most common PI mutation.
Among patients with recent HIV infection, the prevalence of genotypic resistance during the study period ranged from 7.1% in 1998 to 14% in 1999 to 8.9% in 2000 -- differences that were not statistically significant. However, resistance in patients not recently infected increased from 3.2% in 1998 to 9.0% in 1999 to 12% in 2000 (p = 0.004). Notably, resistance was detected more often among patients who reported having sexual partners who were themselves receiving antiretroviral therapy, suggesting a potential route for the acquisition of drug resistance.
This study complements the HCSUS study and, with previous reports, indicates that drug resistance is present in about 1 out of 10 treatment-naive patients. While the impact of pre-treatment resistance on response to therapy is being studied, many clinicians are deeming it prudent to test patients at baseline. Continued monitoring of resistance patterns in the treatment-naive will be essential to understanding the need for on-going pre-therapy testing and gauging whether drug resistance patterns are evolving with treatment trends.
Too Much Adherence Begets Resistance
Resistance to HIV therapies can develop for a number of reasons, including nonadherence, sub-optimal plasma concentrations of antiretrovirals due to malabsorption or drug interactions, and, as is evident from the above discussion, infection with drug-resistant virus. Most clinicians blame nonadherence for the lion's share of resistance seen. However, how much nonadherence it takes to produce drug resistance is still unclear. Very low adherence to therapy may actually carry little risk of resistance as there is insufficient pressure placed on viral strains to select for resistant mutants. Likewise, high rates of adherence may shut down viral replication and, subsequently, cut back opportunities for mutants to emerge. These considerations have led to the conception that the relationship between adherence and antiretroviral resistance is bell shaped, with the risk of resistance low during low levels of adherence, peaking with intermediate adherence (not too little, not too much) and falling with high-level compliance.
Many researchers suspect, however, that the relationship between adherence and resistance is more complex and that the risk of resistance may actually increase well beyond the midpoint of adherence to include rates that are clinically common and actually considered fairly good. This is most evident when a patient's viral load remains detectable despite taking combination antiretroviral therapy and when HIV replication persists at a level sufficient to produce resistance mutations. In such a situation, it is not clear precisely where is the tipping point beyond which more adherence will risk more resistance. Certainly, more adherence may increase the rate of achieving an undetectable viral load, but for patients falling short of this goal, more adherence, although laudable, means more drug exposure in the face of on-going replication and, as a consequence, drug resistance. This is not to say that clinicians should not be egging their patients on to better levels of adherence. Rather, in certain circumstances in which viral replication continues, more adherence is a double-edged sword in that although it may help shut down the replicative machinery, it may also make resistance more likely. The study below demonstrates these points nicely, taking advantage of the unique opportunity to study cohorts with well characterized adherence and virological data.
Bangsberg DR, Porco TC, Kagay C, et al. Modeling the HIV protease inhibitor adherence-resistance curve by use of empirically derived estimates. J Infect Dis. July 1, 2004;190(1):162-165.
Can the risk of developing PI resistance at varying levels of adherence be predicted? That's what investigators from California, with expertise in studies of antiretroviral adherence, tried to do by creating a model based on data from their clinical research. The data were generated from 2 cohorts of patients receiving antiretroviral therapy who had viral load determinations and unannounced pill counts performed regularly. One of the cohorts also had genotypic resistance testing performed. Importantly, both of the populations who were used to create the model were heavily treatment experienced.
Based on their study of these cohorts, the authors calculated that the probability of viral suppression below 50 copies/mL increased with greater adherence. This meant, for example, that at 100% adherence, close to half of the treatment-experienced patients would have undetectable viral loads. Among viremic patients, the risk of drug resistance actually increases with adherence. That is, for patients with detectable virus, the more drug they took, the greater their risk of resistance -- with the greatest risk being at their highest level of adherence. When the model considered all patients -- viremic and aviremic -- the maximal rate of new PI mutation acquisition occurred at a level of adherence of 87%, with the risk of resistance fading with additional adherence. The graph of the adherence-resistance relationship was therefore slanted considerably to the right and looked more like a plot of the Dow Jones Industrial Average from 1970 to 2003 than a bell.
The data used to generate the model were derived from patients who were receiving unboosted PIs, which are clearly less potent than boosted PIs. However, adding to the model the regimen's effectiveness as determined by the percentage of patients on that regimen who had undetectable viral loads at 100% adherence, resulted in the shifting of the peak of the adherence-resistance curve back to the left and down, with the most potent regimens yielding resistance less often and maximally at adherence rates of around 50%. More potent regimens therefore reduce the overall prevalence of resistance mutations and are more likely to suppress viral replication at lower levels of adherence than less potent regimens.
This model is useful in several ways because the adherence rates of most clinical populations that have been studied to date are at the range of 80 to 90%, which has been found to be most associated with PI resistance.18 That the levels of adherence which were calculated in this study to be associated with the greatest risk of the development of resistance in treatment-experienced patients are quite similar to those seen clinically provides a potential explanation for the high prevalence of resistance seen in the HCSUS cohort.
The results are also provocative because they suggest that increasing adherence in treatment-experienced patients on regimens may paradoxically increase the risk of resistance if viral suppression is not achieved (i.e., according to the model, improving a patient's adherence from 70 to 87% would appreciably increase the patient's risk of cultivating resistance mutations to his or her PI).
These results have several implications for clinical practice. First, they make plain that greater adherence, if it is unable to drive down a patient's viral load to very low levels, is not necessarily always better. Second, clinicians need to remain vigilant in monitoring for resistance even when a patient's viral load has fallen but remains above the limits of detection despite the patient's high-level swear-on-a-stack-of-bibles adherence. Lastly, to avoid further resistance, a low threshold for changing therapy (when possible) is advisable in cases where viremia persists.
Certainly, the problem with such models is simply that they are models. Further, this particular model is based on data from patients on therapies that are less potent than those being commonly employed today. It also assumes virologic failure to be a gradual process, in which resistance mutations accumulate, which is not always the case. Despite these limitations, the model is thought provoking and challenges our assumption that greater adherence is always better in patients who are heavily treatment experienced. As the potency of regimens increase, the odds shift and adherence pays off but high levels of adherence are still required to suppress viremia and prevent the cultivation of resistant virus.
What Do Patients Want?
Exactly what do patients desire in an antiretroviral regimen? What keeps them from the kinds of adherence that makes treatment success likely? Most of us think we know the answers. Some of us consider what we would want if we were faced with having to start an antiretroviral regimen. Others base their opinions on what their patients tell them. However, specifically what patients themselves desire in a long-term regimen may surprise those on the other end of the prescribing pen.
Stone VE, Jordan J, Tolson J, Miller R, Pilon T. Perspectives on adherence and simplicity for HIV-infected patients on antiretroviral therapy: self-report of the relative importance of multiple attributes of highly active antiretroviral therapy (HAART) regimens in predicting adherence. J Acquir Immun Def Syndr. July 1, 2004;36(3):808-816.
In a rather straightforward study, conducted in 6 cities across the United States and sponsored by GlaxoSmithKline (the manufacturer of popular twice-a-day regimens), 299 patients who were receiving a minimum of 3 antiretrovirals were surveyed regarding their HIV treatment preferences.
Participants were asked to evaluate 10 therapy attributes and predict their adherence to each of 7 actual regimens. The 10 treatment attributes were: total pills per day, pill size, side effects, dietary restrictions, dosing frequency, number of prescriptions, number of refills, number of copayments, number of medication bottles and whether bedtime dosing was required. The 7 regimens all contained 3 active antiretrovirals and were dosed either once a day (QD) or twice a day (BID). Participants were told to assume the potency of the regimens was equal but the actual names of the components were not provided.
The 3 QD regimens, although never disclosed, are presumed to have contained efavirenz (EFV, Sustiva, Stocrin) since 1 agent was always required to be taken at bedtime. Only 1 QD regimen had all 3 agents taken simultaneously and this sounded a lot like efavirenz + didanosine QD (ddI-EC, Videx EC) + lamivudine. None of the QD regimens were described as 3 pills before bed with little or no food (i.e., tenofovir [TDF, Viread] + lamivudine [or emtricitabine (FTC, Emtriva)] + efavirenz). The BID regimens ranged from a zidovudine/lamivudine/abacavir (ZDV/3TC/ABC, Trizivir)-like regimen, to a nelfinavir (NFV, Viracept) + tenofovir + lamivudine combo weighing in at 13 pills with food requirements.
The subjects were mostly male (76%), African-American (45%) and men who have sex with men (57%). Two thirds were on their third or more antiretroviral regimen. Only 26% said they had missed no doses of their HIV therapy during the preceding 3 months.
All 10 attributes were deemed to negatively affect adherence. Mean number of pills per day having had the greatest impact followed by dosing frequency, adverse events and dietary restrictions. Bedtime dosing was rated by patients as having the least impact on adherence. When evaluating actual regimens, respondents rated the zidovudine/lamivudine/abacavir regimen the most likely to be adhered to and the most convenient. The runners-up included 4 regimens that had received similar ratings, of which 3 were the QD regimens. As can be expected, the regimens with the most pills fared the worst.
Women rated dosing frequency and side effects as less of an issue than men, food restrictions were more of a concern among whites compared with non-whites and African-Americans reported less of an impact from side effects than whites or Hispanics.
This study, despite some limitations described below, provides an interesting perspective on what matters most to patients who are confronted with the need to take daily life-long therapy. Pill count, frequency and side effects were considered the most troublesome aspects of therapy and the greatest threat to adherence. Bedtime dosing, interestingly, despite the potential inconvenience of having to take a medication at a specific time of day, was not considered a relatively significant treatment liability.
The flaws? For one thing, the comparison of regimens was, unfortunately, somewhat stacked in favor of the 1-pill, BID option (the pill count and frequency of Trizivir, manufactured by the sponsor of this study). The QD regimens described had more negative attributes than can be found in the currently popular QD combination of tenofovir + lamivudine + efavirenz. Additionally, the soft-pedal warning regarding the "very slight chance your body will react to this medicine, which would require you to stop this medicine" -- otherwise known as the abacavir (ABC, Ziagen) hypersensitivity reaction -- which was included in the 1-pill, BID regimen did not provide participants with a completely balanced picture of this option. Lastly, the assumption of equal potency, which was understandably made for the purposes of this study, nevertheless should not extend to the interpretation of the results when crafting an antiretroviral regimen. When the chips are down, potency counts and I suspect many patients would be willing, to a point, to trade some convenience for efficacy, but fewer would agree to the reverse. Obviously, when potency and convenience are combined, everyone wins and, as mentioned above, powerful once-a-day therapies with low pill burdens are available today.
The range of responses in this study also demonstrate how individual treatment preferences can be. For some, pill count is paramount to frequency, for others food restrictions were a more important attribute. These results serve to remind clinicians not to assume we know exactly what regimen our patients would desire. Despite our understandable embrace of once-a-day regimens, a potential treatment regimen is not only about frequency. A frank discussion of the pros and cons of the treatment options is essential prior to handing over those prescriptions.
This article was provided by TheBodyPRO. It is a part of the publication HIV JournalView.


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"Inkspell indeed"
I am not sure why this book was rated 1 star by another customer, but I found the book to be a truly enjoyable title. I got lost in this inky world and can't wait for the last book.
Brendan Frasier was a little distracting at first and I don't like his "Elinor" voice, but after a while, I grew to like him. Though, I still prefer Lynn Redgrave's reading of Inkheart.
This is a worthy sequel to Inkheart (Please read that one first, or you will be lost). The translation is excellent and the book sounds as if it were originally written in English rather than German.
A must read for all book lovers who still have that sense of wonder about the worlds between the pages of a book.
"Hooked on Inkworld"
This is my first time providing feedback on an audiobook, although I've been an avid 'listener' for years now. On the recommendation of Audible, I downloaded Inkheart and thoroughly enjoyed the story and Lynn Redgrave's wonderful narration. I quickly went in search of the sequel, Inkspell, and was a bit disappointed when I heard Brendan Fraser's voice narrating it but was quickly surprised and impressed with his ability to bring the characters to life. This was one of those books that made me look for an excuse to drive somewhere so I could listen to it in the car, and made it really difficult to get out of my car once I got back home!
I was on the edge of my seat at the end of Inkspell, waiting for the whole story to get wrapped up, when I realized, with only 14 minutes left, that this wasn't going to happen and there would be a sequel. I'm disappointed that the sequel isn't available yet, but I'm counting on it being as wonderful as the first two books of the trilogy. This is a wonderful story for adults as well as children, and well worth the time spent listening to the unabridged edition.
"Brendan Fraser??"
While my husband and I are enjoying the story and writing in Inkspell even more than the original Inkheart, the switch in readers from the very talented Lynn Redgrave to the very.... um... good-looking.... Brendan Fraser has made listening to this series a chore. We have several times been tempted to go purchase the actual book so we can finish the story without Fraser's horribly jarring narration, but having spent so much money on the audiobook here at Audible, we feel like we might as well try to finish it.
Our chief complaint is his decision to voice almost all young or female characters as shrill and screeching. We dread the chapters featuring Elenor, though Redgrave's portrayal of her in the first book made her one of our favorite characters. Also irritating is how almost every character is given a strong foreign accent based apparently on cultural stereotypes. Even though almost all of these characters are supposed to live in the same general region and speak the same language, romantic women have thick Tuscan accents, evil women have a strong Russian accent heavily reminiscent of Bullwinkle cartoons, uppity characters have French accents so thick you can barely make them out, criminals are Cockney, heroes are Irish, the only character actually described in the story as Italian sounds like a Jersey mob boss, and the only Black character, of course, sounds like he could have starred in Forrest Gump. Finally, Fraser's constant. over. enunci. ation. of. words. for. em. pha. sis is driving us nuts. This isn't Star Trek!
This is a very entertaining and well-written story, but if the quality of the narration is at all important to you, I recommend purchasing the actual book and reading it yourself.
"loved it!"
I thought Inkheart was wonderful, but Inkspell outdoes it. The Ink world is so imaginative and evocatively realized. I also did not know it was the center of a trilogy so the ending was more of a non-ending in the way of the Empire Strikes Back from the Star Wars trilogy, which is not saying that it takes away from the book in any way (we all know Empire was the best of series). I am really looking forward to seeing how it's all going to be resolved. I'm not a child and found the story to be absolutely compelling and complex enough for adults; I actually think it may be a bit too much for younger children - there is violence and death.
BTW, although not withstanding a few quirks (a sometimes staccato delivery, wildly speeding up the narrative to convey exciting action, and placing too much emphasis on certain words when it's not really necessary) Brendan Fraser does an excellent job narrating. He's one of the few book readers that understands his job is to entertain and "perform" the story, which he does with exuberant enthusiasm. With some of the characters I actually forgot it was still him reading (although his Elinor was quite annoying). I do think Lynn Redgrave slightly outdoes him (her Elinor was quite a hoot and kept me looking forward to those parts of Inkheart when Elinor was included - very funny), but overall I really enjoyed him and hope to be able to hear more of him in future books.
"Great Book, but bring back Lynn Redgrave!"
This is a worthy sequel to Inkheart. Even as an adult, I love the plot within a plot and the characters. And Lynn Redgrave's reading of the first book in the series was exquisite and subtle yet shows the depth of the characters written by Cornelia Funke. I so wanted to enjoy this book equally well. But I didn't.
I never thought that the wrong narrator would make an achingly hard listen for me. But I found out I was terribly wrong.
Frankly, Brendan Fraser is the wrong narrator for this sequel. Perhaps no one can follow Redgrave. However, Fraser overacted every character using trite characterizations (see some of the other evaluations). I found myself cringing as Dustfinger, Elinor and others were voiced. And, sometimes I found it difficult to understand his words, the accents were so strong; this was frustrating as well.
Having said that, I do think that Brendan Fraser may be a good narrator for the right kind of book; and as his skill develops, perhaps his approach will become a little more subtle. Little pieces of his work in this title are actually very appealing (some of the sighs, the tempo, phrasing and other things) so I will not give up on him as a narrator.
However, if this book is ever re-released narrated by Lynn Redgrave, I'll not hesitate to buy another copy!
While I'm not a huge Cornelia Funke fan (I listen in the car, with my daughter, who is), I was drawn into "Inkheart" by Lynn Redgrave's skillful and coherent narration (full disclosure: we both have a certain preference for the stage-trained English voice).
Brendan Fraser's take on "Inkspell" is hugely disappointing (both listeners agree). His accents are inconsistent, and all over the (world) map, marked by bursts of strident enthusiasm, and ... gratuitous ... pauses ... for ... emphasis. But, judging from other reviewers' positive response, taste in narrators, as in all else, is ever personal...
"Not as good as the first"
I had a hard time staying engaged with this story as compared to the first. I think after hearing the voices of the lady reading it in the first one, it made listening to Brendan hard for me to get into. I kiss found myself tuning out a lot and missing minutes at a time, so I may not be the best reviewer. I do love this series though. You have to listen to this one before the third one of course.
"Still Fun"
Unlike (and I know I bash Potter too much)Rowlings books, the second installation of Inkheart still held my interest. The world inside the book remains realistic and the characters, despite admitted dimensionality stay clever. If you liked the first one, this is realiably more of the same.
"Silver Tongue Reads This One!!!"
Exceptionaly good book. My son started reading it before me and he kept saying that Brendan Fraser was too good of a reader. I laughed and didn't pay much attention. Now that I have listened to Brendan I am shocked at how wonderful he was. The voices were wonderful. "You felt the book comming to life, as if this is what it had been waiting for." Listening to this book I am almost shocked the characters were not next to me. I am disapointed that he did not read all three of the books. I will gladly purchase the book Dragon Rider that he reads also.
As for the book itself, If you didn't like the first one, give this a try. If you did like the first one... DO Not Pass this one!
Again it is hard to read Ink Death without Brendan!
"An excellent narrator"
I prefer not to make comments on books as I believe each person needs to delve into their realms untarnished by the judgements of others. As such, this review is actually for the narrator.
Brendan Fraser is an amazing reader. I've liked him well enough in the various movies I've seen, but I had no idea I would enjoy this book so much more because of him. He has a pleasant voice which tells the story easily and blends well into the narration, allowing the many characters in this book to really attain a life of their own. His accents, tones and lilts are wonderful. It's so much simpler for me listening to a book this way, since I'm rarely sitting still while reading. The ability to differentiate between characters without having to rewind is invaluable.
I've enjoyed this book very much, more so than I did Inkheart, because of his reading. What a delightful surprise!


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Summer Hours Begin: Central Library will close at 6 pm on Thursdays and will be closed Sundays until September. Enjoy your summer!
Log in
Storytime with Mr. Steve & Friends started off with a bang with special guest Professor Code from Western Michigan University's School of Music.
Professor Code shared four different instruments with us: the Swedish nyckelharpa (keyed fiddle), the Norwegian hardingfele (Harding fiddle), the Norwegian seljefløyta (willow flute) and the munnharpa (mouth harp).
He also broke our bean bag balance record, balancing 13 bean bags on his head while counting in Norwegian!
Join us for books, rhymes, crafts, parachute games, and a surprise special guest at the next Storytime with Mr. Steve & Friends on Monday, October 26 at 6:30 pm at the Central Library.
Posted by Steve Siebers at 09/29/2009 11:05:24 AM
Books for: Kids, Teens & Tweens


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What is your strategy to grow the channel faster with partners?
We want to build deeper links to the segment sales organizations that we have in the company and continue to build that knowledge of how to leverage each other and expand and grow together. The set of capabilities that we have—in terms of data center offerings, storage, networking, systems management, data protection, identity management, security— are unbelievably broad. Having done 30 or so acquisitions, we'll keep doing acquisitions. And, of course, as a private company we can be more aggressive. We are thinking about the medium term and the long term. We don't have to think in 89-day planning cycles.


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Instagram for Android: Open for Registration Now!
Instagram for Android: Open for Registration
Three months ago, Instagram made it known that they'll be bringing their popular photo-sharing app to the Android platform. We knew that a lean team of two was working on the project, although we didn't hear of any concrete release dates then. As announced by The Next Web recently, Instagram has created a site for Android users to sign up for a likely beta release before it hits Google Play. To do so, simply enter your email address in the single field found on the teaser page.
Upon registering, users would see a message "Thanks for signing up! We'll be in touch soon" which suggests users will be notified once the trial copy is available for download. According to The Next Web's report, Instagram has scored a massive hit on iOS devices with an impressive following of 27 million users to date. Instagram's CEO, Kevin Systrom, also hopes that their 'audience would double' with the upcoming release of the Android app.
Conversely, Instagram is a little late to the Android party considering that other similar applications such as Lightbox, Snapr, EyeEm and many others have already established a foothold on Google's mobile platform. It'll be interesting to see if the popular photo-sharing service would enjoy the same success as it did with Apple's mobile operating system.
Source: The Next Web


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Bearded Collie Description
Looking to adopt a Beardie or Beardie cross ("Neardie") from March 2017; female; pup or (preferably) rescue up to 3 years old. For loving home in Bristol.
Contact the Advertiser
Sorry, you are unable to contact this advertiser as you are not logged in. Please either login or register.
Registering takes 1 minute and is completely free of charge. Once registered, all contact details will be revealed.
We ask people to register to help build a safe community for the animals, buyers and sellers.
Problem with this Advert or Seller?
If you experience any problems with the seller or find the conditions and well being of the animals not satisfactory, please contact us immediately to let us know. We will then remove the seller from the site and may report them if we deem it necessary.
Don't buy a puppy if you suspect anything is wrong. The best thing to do is report this immediately.


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The #NRL Ladder after Round 11. Souths and Cronulla march up the table while at the other end, the T...
23 hours ago
Last night on 2GB Ray Hadley, Steve Roach and Tony Megahey were at the Penrith Football Stadium to see the Panthers upset the Roosters. But it was not smooth going for 2GB or Ray Hadley.
Midway through half time announcers said, "Steve, Tony and hopefully Ray Hadley back for the for the second half". Hadley returned but within 10 minutes he had to leave again. Jimmy Dolen filling in.
While on air, Hadley exclaimed, "I have felt crook 5 minutes before the game and have ever since". It was the same for the rest of the second half he kept going and coming back.
Ray believes that he will back today for the Souths vs Bulldogs game.


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Miami here I come!!
Ok, so basically I have a co-op this summer in Miami, FLthat I got through RIT's Student Co-Op Office, which is absolutely amazing bythe way!
My co-op is with Burger King Incorp. (Yes I will be workingfor THE Burger King!) and it gets even better; they are giving me a housingstipend so I can live where I want in the City of Miami. So I figured I wouldtake advantage of the opportunity to live in Miami over the summer, so I got astudio apartment in South Beach, FL! I am so excited but it's not going to befun and parties the whole time I'm there. I am also taking 2 summer courseswhile I am working over 40 hours a week at BK. But, that doesn't mean I can'tenjoy South Beach living and possibly meet a few celebrities along the way!
Ok, so now down to the nitty-gritty. I am a PackagingScience major at RIT and yes I do design more then just boxes. For my co-op Iam working in BK's Global Operation's Department for Sustainability; my maintask is to make BK's to go containers more environmentally friendly such asbeing biodegradable and easily recyclable. The main reason I have this task is because the Seattle,Washington passed a law that all restaurant to go containers must be recycledor biodegrade in less then 80 days and normally it's within 160 days.
I will be driving from Erie, PA to Miami, FL (which is about23ish hours) and then start my first day of work on June 1st.
Wish me luck!
Hopefully the traffic and the heat/humidity aren't too awful.


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Stitching can be its own art form and transform your quilt design. Our first guest is Ellen Anne Eddy. She has a basic lesson on darning feet and also tips for choosing batting. Then, meet Laura Wasilowski as she "arts" up a traditional quilt block with fusible web. We finish up with Carol Ann Waugh and adding texture to quilted pieces with couching.
Visit the Website: http://www.quiltingartstv.com/
Episode #1110 / Length: 28 minutes


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RACE walking and wheelchair rugby would appear to have little in common.
But both shared the spotlight at the Ballarat Sportsmen's Club's awards night at the Ballarat Lodge, with Jared Tallent and Greg Smith jointly named 2012 Ballarat Sportsperson of the Year last night.
Tallent won the award for the fourth time, his third in succession, while it was Smith's first Ballarat Sportsperson of the Year award.
It was only the second time in 53 years the honour has been bestowed on the two athletes in the one year, the only other occasion being in 2004 when Anthony Edwards (rowing) and Allison Tranquilli (basketball) shared the award.
Smith, who won gold at the London 2012 Paralympic Games and was the Australian team flag bearer at the games, said it was a privilege to share the prize with Tallent.
"It's fantastic really," the 45-year-old said.
"I kind of thought I'd come along and have a good night and enjoy a nice meal.
"I knew Jared was a big chance. He had an amazing year so it is great to share it with him. It's also a great end to my career as an athlete.
"I've been nominated two or three times before. One of those years Steve Moneghetti won it and the other was Russell Mark. They're all such icons of Ballarat."
Tallent was in Canberra last night, preparing for the national championships next weekend in Hobart, and was unable to attend the presentation ceremony. The 28-year-old's award was accepted by his mother Kath.
"They all mean a lot to him," Kath Tallent said. "He's very proud of being from Ballarat.
"He would have loved to be here but it is so hard for him to get here because the nationals are always this time of the year."
Tallent was a silver medallist at the London Olympics last year in the 50km walk, after silver in the 50km walk and bronze in the 20km at the 2008 Olympics in Beijing.
There were 13 nominees for the 2012 Ballarat Sportsperson of the Year: Luke Barby, Collis Birmingham, Anthony Fisher, Tamsin Hichley, James Marburg, Kathryn Mitchell, Tara Pilven, Aislinn Prendergast, Patrick Shaw, Shannyn Johnstone-Ward and Mathew Wiltshire, in addition to Smith and Tallent.


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Our nation is facing a paradox involving access to justice. On the one hand, too many people with low and moderate incomes cannot find or afford a lawyer to defend their legal interests, no matter how urgent the issue. On the other hand, too many law graduates in recent years have found it difficult to gain the practical experience they need to enter practice effectively.
The American Bar Association is uniquely positioned to connect the unmet legal needs of our society and the unmet employment needs of our young lawyers. At my request, the ABA is convening a task force of experts in legal education, legal aid and legal service delivery to determine how we can help resolve both problems together.
Legal "incubator" and residency programs, hosted by law schools and bar associations, are providing good practical experience for recent law graduates who serve populations with unmet legal needs.
Public interest models are also emerging. Lawyers for America, founded by the University of California's Hastings College of the Law, provides two-year fellowships during students' final year of law school and their first year as new lawyers.
Read the full letter from American Bar Association President James R. Silkenat in the ABA Journal here.


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What Herb walk with Brigitte Mars
When 10 a.m. to noon May 19
Where Meet at Pharmaca at 17th and Pearl streets, Boulder
Cost $20
Info Reserve a space at brigittemars.com
Etc. Walk helps identify common edible plants in urban environment
What a winter.
Anyone who has lived in Colorado is accustomed to wild temperature swings and the rapid switch from snow to sun. What Coloradans are not so accustomed to is so many snowy days on top of each other. It's been almost Midwestern. No wonder, then, that the old body is a little confused -- should it burrow down for more of the interminable shoveling snow and trudging through slush or lighten up for spring.
With all the confusing signals from Mother Nature, perhaps it's time to help the body through that transition to spring. One way is to take a look at traditional societies and how they handle the end of winter.
A main thrust is to eat lots of those newly available spring greens, as well as to drink teas that served as spring tonics.
"Burdock root as tea, dandelion root as a tea, nettles," says local herbalist Brigitte Mars. She adds that salads made with local greens and strawberries are a great way to jump into spring with both feet.
"Nature is coming to life again," she says. "It's time to begin new projects, clean our homes and rejuvenate our bodies. Rather than a heavy diet, eat salads, soups and green leafy vegetables."
She adds that people should follow their natural circadian rhythms by getting up earlier and getting out of the house more.
"It's a wonderful time to start visiting your friends and offering them a wonderful tea when they come around," she says.
As spring gets a little further along, she suggests soaking lilacs in a carafe of water for an hour.
"Strain it and make a beautiful lilac-infused water," Mars says.
Esther Cohen, a registered dietitian in Boulder and founder of the Seven Bowls School of Nutrition does a spring cleanse every year and recommends one for her clients.
"It's really about establishing a new baseline, like pressing the reset button on your computer," she says. "You reestablish your whole metabolic field."
While her cleanse classes ended the first week of May, many people who are still feeling stuck in winter can benefit from a cleanse -- or spring tonics and teas.
"It's the time of the liver in Chinese medicine," she says. "The liver is the main organ of detoxification. Liver also houses the emotion of anger. When you detoxify, you start to release old anger."
Sour flavors -- especially lemon -- are also part of the Chinese approach to spring, Cohen says.
"Hot lemon water in the morning is excellent," she adds. Cohen also suggests green drinks such as smoothies made with kale, chard and watercress. She adds ginger, which is warming. Smoothies also include berries.
Supplement-wise, she suggests Vitamin D3 with Vitamin K, which helps the body recover from getting less sun in the winter.
She also makes a tea from dried dandelion leaves, nettles, hibiscus, red clover and lemon balm, which she says helps with allergies.
Her favorite tonic -- one that she imbibes of year-round -- is one she learned about in Bali and which she calls a Turmeric Sunrise. The drink is made from orange juice, lemon juice, ginger, turmeric, tamarind and honey.
"It's very anti-bacterial and anti-microbial," she says. "I do it almost daily. (Clients with) arthritis and all kinds of conditions are able to diminish medications."
In the three-week cleanse she suggests, participants eliminate all processed foods from their diets, remove gluten, dairy and soy. They eat lots of vegetables, especially greens dressed with olive oil and lemon. Protein-wise, they start out eating red meat such as beef or lamb (for those who eat red meat), progress to chicken, fish, legumes, nuts and seeds, spend two days eating only vegetables and then a fast for one or two days with lemonade and broth made from beef and vegetables.
"It's an opportunity to give the digestive tract a bit of a vacation," she says.
Mars, the Boulder herbalist, says spring is a time to lighten your life in a myriad of ways.
"For those thinking about losing weight, when you clean your house and get rid of stuff, it becomes a metaphor for detoxifying the body," she says. "Get rid of the clutter in the basement and the garage. Get lighter, more streamlined."
Spring tea
1 cup dried dandelion leaves
1 cup dried nettles
1/2 cup hibiscus
1 cup dried red clover
1 cup lemon balm
Directions: Mix together and store. To make the tea, take a half cup of the mixed herbs and place in a glass quart jar. Cover with boiling water. Let steep two hours. Drink it hot or cold. Two cups a day will last for three days.
Source: Esther Cohen
Turmeric Sunrise
Juice of one orange
Juice of one lemon
1/2-inch piece of ginger, peeled
11/2-inch of turmeric root peeled (available at natural food stores and Asian markets)
1 teaspoon tamarind paste
Local honey to taste
Directions: Blend in a blender until smooth.
Source: Esther Cohen


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Hi, I'm having a problem implementing 2 things in my code. I am struggling to let the user input the number of the correct definition.
print ("1) ", answers[0])
print ("2) ", answers[1])
print ("3) ", answers[2])
z = realAns
for z in range (len(def)):
if realAns == def [z]:
position2 = z
CorrectOne = input("Pick correct definition and input number 1,2 or 3: ")
if Correctone == realAns[z]:
print ("Well Done you Solved it!")
I believe the problem is with this part of the code. People who are confused, I am trying to let the user input the correct number which corresponds to the definition. However, I am struggling to do this as the error comes up as string out of range? What do I need to do to fix this!? Furthermore, I have no idea how to start to implement a part of a code where when the correct definition is picked twice correctly for the same answer, the definition will automatically remove itself.
Thanks for any advice given!
(I am new to python)


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Broadway or Bust at 7 pm Sunday tracks the real-life stories of America's top high school musical performers, vying in the ultimate competition to find the nation's best young rising stars.
With Wallander's work now getting too close to home, he follows the leads of two investigations that become increasingly entangled on Masterpiece Mystery! at 8 pm Sunday.
The stakes could not be higher as visionary director Robert Lepage, some of the world's greatest operatic artists, and the Metropolitan Opera tackle Wagner's Ring Cycle on Great Performances at the Met on Monday at 8 pm. This documentary is followed by the complete Ring Cycle performance on Tuesday, Wednesday, Thursday and Friday at 8 pm.
Nova "Engineering Ground Zero" at 7 pm Tuesday captures the behind-the-scenes struggle of architects and engineers with the pressures of a tight schedule, the demands of practical office space and efficient, "green" architecture and the public's expectations of a fitting site for national remembrance.
In honor of the 50th anniversary of the publication of "Born Free" — a book and then a film that forever changed the way we think about wildlife, Nature at 7 pm Wednesday returns to tell the story of the lions profiled. What has happened to lions since this story? And what has happened to the people featured in the film?
Trouble Puppet Theater takes Arts In Context at 7:30 pm Thursday on a journey into the art of puppetry as the company produces one of their unique plays led by creative director and master puppeteer Connor Hopkins.
See how to grow olive trees for silvery leaves and maybe a few olives on Central Texas Gardener at noon Saturday. On tour, visit a lawn-reduction makeover with drought tough plants.
Modern rock band Wilco returns to Austin City Limits at 7 pm Saturday with tunes from its LP The Whole Love.


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Fun Friday Night Coming Up Tomorrow – Check out the videos
Even though this is a blog — and a blog is supposed to be an immediate YOU HEARD IT HERE FIRST medium — people have been telling us we should talk more about what's happening the day after our post because they often read the posts the next day. We get it. Not everybody sits at a computer all day — and even some of you who do have bosses that want you to get some work done, not surf the web all day. So here we go:
IT'S A BIG FRIDAY NIGHT on Cape Ann with music for every taste. If you play your cards right, you can get to at least 2 live shows. Start out with Linda Amero Menage a Trio at the Franklin or Mia Chung, Elisabeth Ann Larson and Soo Bae performing all three of Brahms Piano Trios at Shalin Liu in Rockport. Then finish up with Ned & The Big Babies @ Rhumb Line. Plus there's plenty more for nearly every other musical taste. See the full lineup here.
Here's a video for all you piano, violin and cello players of Brahms Piano Trio No. 1 where you can follow along with the score:
And here's one of my favorite clips (if a bit wobbly) of Ned & the Big Babies. Don't you just love that groove! Ned is always right there with you and he's one of those great bass players who plays bass like he LOVES it, not like he'd rather be playing lead guitar.


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Devil's KnotRSS
Movie Description(Click Here To Hide)
In 1993, in the working class community of West Memphis, Arkansas, three eight-year-old boys – Stevie Branch (Jurgensmeyer), Christopher Byers (Spink), and Michael Moore (Boardman Jr.) – go missing from their neighborhood. After an extensive search, their bound and beaten bodies are found the next day. The community and the police department are convinced that the murders are the work of a satanic cult due to the violent and sexual natures of the crime.
Devil's Knot News
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Sure, why not. I choose: Team Edward.
Jared Padalecki or Jensen Ackles.
Mine: Jared
Sure, why not. I choose: Team Edward.
Jared Padalecki or Jensen Ackles.
Mine: Jared
Jared Padalecki or Jensen Ackles?
"Love's for a life time not for a moment, so how could i throw one away, I'm only human and nights grow colder, so i should be loving bothways... yeahh"
Sorry for the rules, but i gotta pick both of them lolz
Superman for sure, way hott.
Tom Brady or Tom Cruise?
mmmmmmm Gotta be Brady, any way he wants it
definitely Paul Rudd.
Peyton Manning or Eli Manning
I have the hots for both, but I choose Peyton.
Peyton, for sure.
Chad Michael Murray or James Lafferty?
I choose Chad.
James Lafferty, for sure!
Zachary Quinto or Wentworth Miller?
Zac Efron definatley
David Beckham or Frank Lampard
Mine is a sandwich of both
Hot and Horny
Ryan Phillippe
Daniel Craig or Sean Penn
Mine: Craig...first at least. Sorry couldn't resist.
Mine: Lucas Till and Christiano Ronaldo...
I have to say Lucas..
that's a tough one...
I think I'd rather fuck Jamie...just grab him by those ears and plunge it in deep.
Channing's a little too groomed for my tastes.
Next Up: Anderson Cooper or Jon Hamm?
Tough one but I'd have to do Anderson Coopr. The eyes gave him the edge.
How about grandsons of famous actors who are now actors as well.
Ethan Peck
Stephen R. McQueen
I think I'd go with Stephen.
I'd go with Gerard Christopher.
Next Up: Dylan McDermott or Dermot Mulroney?
Justin Berfield or Frankie Muniz?
JUB's cuddle bunny since 2005
Kroy Biermann or
Tom Brady
Chris Evans, no doubt!
Next Up: Mike Posner or Robin Thicke?
Matthew Mcconaughey or
Woody Harrelson
Chord Overstreet by far.
Kris Allen or Joe Jonas?
Lenny Kravitz or
Shemar Moore
Based on a google search- chris by a landslide
Kris Allen
Adam Levine
Id have to go Kris--- though I'd be thrilled with either
Eminem or
Lil Wayne
Frankie Muniz or Paul Giamatti?
It's never too early in the year,
to spread some goodwill cheer!
John Cena or
dwayne Johnson (The Rock)
Dwane definitely. I'd bend him over and fuck him till he begged for mercy.
Cole Sprouse or Dylan Sprouse?
It's never too early in the year,
to spread some goodwill cheer!
Lmao Andrew
Josh Hopkins
Josh hutcherson
Hopkins for me
Patrick Stewart. Yeah. You like my black hole, Jean-Luc?
Dwayne Wade, or LeBron James?
Dwayne Wade by far wins over Lebron.
Ryan Reynolds or Colin Farrell?
Reynolds for me, hands down.
farrell would be fun, but i would definitely pick ryan reynolds. hot hunk of man.
adam lambert or james durbin?
Lambert if he scrubbed off the makeup
Scott baio
Ralph macchio
Ralph. He still looks cute.
Kevin Zegers or Corey Sevier
Corey for me.
It's never too early in the year,
to spread some goodwill cheer!
KEllan Lutz of Zac Efron?
I'd take Kellan.
id have to take zac-- even though kellan has a great body-- zac has a pretty face and an excellent body
jon stewart
steven colbert
i think a young jon stewart was SUPER sexy but now days ill take colbert
Egh...if I had to, Stewart I guess.
Garth Brooks or George Strait?
It's so hard to decide...I say George...
No no. Garth without a doubt
Antonio Banderas or Javier Bardem
Javier Bardem
Next Up:
Danny Masterson or Chris Masterson?
Chris Masterson.
Next one: Garrett Hedlund (Sam Flynn from TRON) or Sam Claflin (Phillip from Pirates 4)
My pick out of those two, I'd go with Garrett Hedlund.
Garrett Hedlund:
Sam Claflin
OMG! Chris, without a doubt!! He was the only reason to watch "MITM"!!!
Darren Criss or Chord Overstreet (dark-haired CO)...???
It's DC for me all the way!!!
"Don't wait for the world to be ready. Find what you're looking for."
Joey Graceffa
Sean Paul or Pitbull (singer)
Jason priestly
Matt Lanter
Hard one... Mr. Cena!
Chris Pine or Zachary Quinto
Chris pine
John Krasinkski
Milo ventimigilla
John for me
Domenic Purcell or
Ray Park
Ray Park, sleeping with a ninja sounds cool
Matt Damon or Hugh Jackman
I think Hugh for me
Hugh for me too
Hugh Grant
Richard Gere
Richard Gere.
Levi Johnston or
John Mayor
Levi only cause I feel like John would have an STD
Luke Wilson
Owen Wilson
I'd fuck Luke...Owen's misshapen nose is too distracting.
next up: Tom Hardy or Sam Worthington?
Sam Worthington.
Pitbull or Bruno Mars????


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Editor's note: This is one in a weekly series of profiles on locally owned and operated businesses in Southern Oregon.
What do you do and how long have you been doing it? I do custom mapping for property owners, real estate agents, appraisers; outdoor recreation maps for hunting, fishing, hiking, biking and motorcycle routes for outfitters, guides and lodges; military mapping as well as travel and tourism. I can also provide wide format printing, if they have their own digital file, for a banner or large picture. I've been mapping for nearly 10 years and started the business in 2010.
How long have you lived in the Rogue Valley? We relocated here from Billings, Mont., in October. We came here when we were vacationing and fell in love with it.
What inspired you to go into this line of work? I started doing mapping for Hall and Hall, a farm and ranch real estate company that sells all over the world. I did the mapping there 81/2; years before deciding to strike out on my own.
What decision or action would you change if you could do it again? I wish I would've started earlier. For quite some time, while I was doing the mapping I could see the need for a service such as that. I knew I could do it on my own, but I was afraid to take the plunge. It was the fear of the unknown. Can I really do this and will it work? Can I be successful on my own, or should I stay and work for someone else?
What's the toughest business decision you've made? It was a tough decision to leave my regular, full-time, stable job and concentrate on my own business. Leaving a stable income to boost my business and make it grow and hope I could generate the income that's going to support me on my own. When we decided to move over here, I wondered if relocating the business was going to hurt my business or keep going as I have been. It's been a good move because it's something I do from my home and I map all over the country anyway, because it's done electronically and I can communicate by email.
Who are your competitors? There are mapping companies such as Raven Maps, where its maps are more art detailed for showcase. Mine are more custom to what the customer wants for property they own or property a broker is listing. Mine are more of working maps with a specific purpose.
What are your goals? I hope to get to where I can get a storefront and have my equipment where people can come in and see various maps we've done and have a few employees. I can provide maps for anywhere in North America.
What training or education did you need? When I started working at Hall and Hall, they trained me to do maps. I took a variety of courses on software and general geographic information system work.
What's your advice for budding entrepreneurs? If you have an idea and think you can do it, don't be afraid just go for it.
To suggest ideas for this column about businesses that are at least five years old, contact reporter Greg Stiles at 541-776-4463 or firstname.lastname@example.com
Home Grown: Just Map It
Editor's note: This is one in a weekly series of profiles on locally owned and operated businesses in Southern Oregon.