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AIDS Treatment News
Limited Immune Recovery After Treatment with Antiretrovirals, IL-2; Interview with Clifford Lane,M.D.by John S. James
A person's "CD4 count" (the number of CD4+ T-cells per cubic millimeter of blood) is used as a rough indicator of immune system health. But the CD4 cells which are counted are not all the same. In a healthy individual, there are a billion or more different kinds of CD4+ T-lymphocytes -- each programmed to recognize only one specific antigen (foreign substance, such as part of a protein produced by a bacterium or virus).
In HIV infection, when the CD4 count becomes low (especially under 200), some of this "repertoire" of cells is lost; it is probably not immediately restored when the CD4 count rises in response to antiretroviral treatment (or to treatment with antiretrovirals plus IL-2 (Proleukin®), which causes growth of the CD4 cells which are still there). Eventually there may be some natural recovery of the repertoire -- or researchers might learn how to restore the repertoire by cell transplantation. Meanwhile, it may be possible for the immune system to function adequately even though some of its diversity is lost.
On May 31 AIDS Treatment News interviewed Clifford Lane, M.D., Clinical Director of the U.S. National Institute of Allergy and Infectious Disease. Dr. Lane is senior investigator of a research team which published a recent paper on immune recovery after treatment of HIV with antiretroviral therapy, or with antiretrovirals plus IL-2.(1) To introduce the interview, we wrote the following background section to explain some of the immunology involved.
Background: Different Kinds of CD4+ T-Cells
AIDS Treatment News often uses the term "CD4 cells" as a less complicated way of saying "CD4+ T-lymphocytes" -- which is technically more accurate, since there are CD4 cells which are not T-cells at all. This article is only concerned with T-cells, however.
T-lymphocytes are often named according to the molecules on their surface. CD4+ T-lymphocytes are those immune-system T- cells which have the CD4 molecule on their surface; CD8+ T- lymphocytes have the CD8 molecule. Both cells also have antigen-specific receptors on their surface. Each cell has approximately 10,000 or more copies of its antigen-specific receptor molecules on the cell surface.
The billion or more different kinds of these cells are due to a billion or more variations in the T-cell receptor. These variations occur when the cell is formed (usually near the beginning of life, in the womb or in early childhood). T- cells begin as undifferentiated stem cells -- special cells which are able to mature into any kind of blood cell. Certain stem cells are programmed by the thymus gland to become T- cells; when this happens, certain genes of the cell combine randomly, forming the immense number of different possible combinations. Many of the resulting receptors would cause the cells to attack the body itself, leading to autoimmune disease; these unwanted cells are destroyed in the thymus shortly after they are formed. A billion or more combinations remain -- probably enough to recognize some parts of all of the viruses, bacteria, or other disease-causing organisms the person will ever encounter.
Once a T-cell has been programmed, it can only recognize one antigen; its receptor cannot change further. It begins as a "naive" T-cell (one which has never encountered its antigen). If it does encounter its antigen (many cells never do), it changes into what is known as a memory cell. In a healthy adult, about half of the CD4+ T-cells are naive and half are memory cells; in people with HIV disease, the naive cells are more rapidly depleted, for reasons which are not entirely known.
Both naive and memory cells can divide and reproduce in the blood. This increases the number of cells, which can improve the immune response. But this kind of cell reproduction cannot expand the repertoire, because the new cells, whether naive or memory, are programmed the same as their parent (to recognize the same antigen). Only new CD4+ T-cells formed in a thymic environment can add to the repertoire -- and in adults, the thymus is largely inactive, so these new kinds of cells are usually formed very slowly.
Any group of cells -- usually just a few cells -- which have the identical receptor are referred to as a clonal population, since they probably all arose from a single cell (or clone). Since there can be a billion or more different clones in a healthy adult, it is not possible to count and study them all individually and know which ones are effective against which diseases. To make it possible to study this system, the clones have been divided into various families of related cells; one common system is to divide the many clones into "V-beta" families (the name is from a region of the genes which provide a major part of the variability). The recently published work of Dr. Lane and others(1) studied 22 of these families (which probably account for at least 95% of the total diversity in this cell population).
In the following interview, we occasionally added explanatory comments; these are shown [in brackets].
Interview with Clifford Lane, M.D.
ATN: What has been learned about the loss of diversity of CD4+ T-cells in advanced HIV disease? How much of the immunity comes back when the total CD4 count increases after treatment with antiretrovirals, or with IL-2 in addition to antiretrovirals?
Dr. Lane: The ability of the immune system to come back, following antiretroviral therapy, will depend on how much has been destroyed. The reason for this limited recovery is that the immune system is initially generated by stem cell differentiation through a thymic environment -- and this particular pathway [involving the thymus] appears to play a very small role in the mature adult human.
This has been confusing to immunologists because much of the work on this aspect of immunology has been done with mice and rats -- in which the lifespan of the animal and the lifespan of the thymus are not that different. But in humans, thymic function drops off greatly in childhood and then drops again in puberty, and the adult has very little remaining. There is some left; how much varies between people.
To understand this, it helps to look first at what happens to the adult human immune system following a major insult when HIV is not there -- for example, when the system is decreased through radiation or chemotherapy. The immune system can come back, but generally not all the way back to where it was.
With HIV, it is now clear that as immune health declines, the diversity in the repertoire of cells declines. You can block the virus and allow the total count to come up -- but what comes up, at least immediately, is mainly an expansion of the cells that were already there. The number of cells can increase to a new plateau, which may be higher or lower depending on the patient, and depending on the level of ongoing viral replication.
Even though the count does not go all the way back to normal, and some of the original diversity of cells is missing, you might still have an adequately functioning immune system. This is because the immune system has great redundancy in it. If the virus can be stopped, then with repeated antigenic challenge, what had been in effect a second-line set of clones can expand and become a first-line defense. The T-cell immune system's ability to adapt to the environment is phenomenal; this adaptability is its key characteristic.
Animal studies suggest that the number of different T-cell receptors you need [to maintain good health] is much smaller than the number you can make. You do not necessarily need a great number to be protected. In studies in rats, in which cells were transferred from a healthy animal to an ablated animal [one with its immune system destroyed], it was found that the best protection was from the memory cells compared to the naive cells -- and that it only takes a transfer of about a thousand clones to provide a good defense [in the animal; no similar experiment could ethically be done with humans]. The immune system can adapt, and low-affinity clones [those which are not especially good in recognizing a disease-causing organism] can expand to meet the needs of the environment.
ATN: And in HIV disease, the loss of diversity begins even at CD4 counts above 200, but becomes worse below 200?
Dr. Lane: It appears to be more pronounced as the count drops below 200.
ATN: Is there a similar repertoire with CD8 cells as with CD4 cells?
Dr. Lane: The CD4 repertoire is quite similar over time for a person, almost like a fingerprint; we can look at a diagram of the repertoire even after a year or more, and often tell whose blood it is. The patterns do change if a person has HIV infection, but the changes tend to be gradual over time. CD8 T-cells, on the other hand, are always coming and going in the blood, and they have a very chaotic repertoire. This difference may reflect the role of the CD4 cells as the control center of the immune system, vs. some of the more effector limbs of the system [such as the CD8 cells], that need to change more rapidly to deal with whatever the emergency is. The CD4 cells are more for surveillance, keeping an eye on things.
ATN: I heard that in cancer, after chemotherapy there could be some slow immune recovery over years.
Dr. Lane: That is true, but usually the system does not get all the way back to normal. Part of this slow recovery over time may be a trickling of cells through a thymic environment, in patients who have some remaining degree of thymic function.
ATN: What does this mean for prophylaxis of opportunistic infections -- pneumocystis, for example?
Dr. Lane: To me the first message is that if you are following a patient with a CD4 count of 50 who is on Bactrim, and start combination antiretroviral treatment and a month later the count is over 200, I would not stop prophylaxis at that point, as [immune recovery] takes time. Six months out, it would be a good question for a clinical trial. We simply do not know the answer today. Each physician needs to use his or her own judgment about the risks and benefits of prophylaxis [when it might or might not still be necessary, after partial immune recovery due to antiretroviral treatment]. The risk of an opportunistic infection is probably somewhat less [after the T-cell count rise] -- but how much less is unclear. It's not black and white; the immune system is not static but is actively changing, to try to do its best in host defense. Once the negative influence of HIV is taken away, what is left of the immune system can probably do a pretty good job.
IL-2 and CD4 Cell Increase
[Note: Dr. Lane suggested that AIDS Treatment News disclose that, as part of his government duties, he received a patent for his work with IL-2.]
ATN: In the recent paper(1), your team studied not only antiretroviral therapies to increase T-cell counts, but also IL-2 [which stimulates the growth of T-cells]. Is it the same picture with IL-2, of increasing only the cells that are already there?
Dr. Lane: Yes, with IL-2, the cell increases you get are an expansion of the cells already present. But there is one slight difference. The paper(1) looks at the increase in two different ways. Besides the V-beta families, our study also measured naive vs. memory cells, and found that in the setting of antiretroviral therapy alone they increased in parallel. (Naive cells are depleted most rapidly in HIV, and some patients with CD4 counts under 50 may have almost no naive cells.)
With IL-2 there is some preferential increase in naive cells. But though this makes the ratio of naive to memory cells more normal, it is probably not a benefit -- it may make the increase with IL-2 a little less desirable than the increase with antiretrovirals. Because with antiretrovirals, the cells that increase will tend to be in proportion to what antigens, what pathogens, are there. So, with antivirals alone, you may get a cell expansion which is directed more appropriately to each individual patient -- while with IL-2 you may get more of an expansion of whatever clones are there.
I do believe that the new cells [produced by IL-2 treatment] are totally functional CD4 T-cells.
ATN: But the only way to prove that is a large clinical trial -- since we do not have an accepted marker, like viral load, for immune treatments?
Dr. Lane: I feel very strongly that a phase III trial is needed. Before using IL-2 on a large scale for HIV treatment, we need to be sure that its benefits outweigh its disadvantages. There is often a burst of virus when IL-2 stimulates T-cell growth. And there are side effects of this drug. The T-cell increases are substantial and impressive. But unless they provide clinical benefit, they would not be very meaningful.
The problem is that to deliver IL-2 easily, you want to work with an earlier patient population -- because then you can use lower doses and give the drug less often. But to obtain clinical endpoints in an early cohort requires many patients to be followed for a long time.
This is a central challenge now in HIV medicine -- how do we determine the best way to manage patients? While short studies looking at changes in viral load will be helpful in determining the most potent antiviral drugs, I am not sure they will give us a clear picture on how best to manage patients over years.
ATN: What patient population should be studied with IL-2?
Dr. Lane: We are talking about those with a CD4 count of 350 and above -- and letting the antiretroviral strategy be at the discretion of the physician-investigator.
ATN: In that case, if the antiretrovirals work well enough, the trial will not get clinical endpoints, and it will not prove anything. But in case the antivirals do not work well enough over the long period, then you will see if there is any additional benefit from the IL-2. Is that the rationale of this trial?
Dr. Lane: Exactly. You are trying to increase your margin, increase the safety net. If drug resistance eventually develops, the patient will probably be better off with a CD4 count of perhaps 1,000 than with a CD4 count of 200. But if we can totally block the virus and maintain a healthy immune system with antiretrovirals alone, there will be no role for IL-2.
We now know how to use IL-2 with less toxicity than before and how to generate similar results with self-administered subcutaneous dosing(2), especially in early patients (in advanced patients you need higher doses). In early patients, my guess is that after three 5-day cycles of IL-2 over a six month period of time, we will be able to almost double the CD4 count. Then we can spread out the cycles of IL-2 -- maybe once a year, or once every two years.
ATN: Measure the CD4 count and give IL-2 only when they need it?
Dr. Lane: Yes. This is like the induction vs. maintenance used with many different kinds of therapies.
ATN: But with advanced patients you would have to treat more often?
Dr. Lane: Probably. It would become a more difficult clinical trial to carry out. And the answer for one group of patients should apply to the other as well -- since the key question is whether increasing the CD4 count as a result of IL-2 therapy is of clinical benefit. I think that the strategy of running a trial with more patients for a longer period of time, but with a regimen which is easier to administer, is probably more effective [than a smaller trial which uses a higher dose of IL-2 with more side effects].
ATN: The ethics and acceptability of this trial look quite good. It would not interfere with peoples' antiretroviral treatment at all; they would use whatever they want, and the IL-2 treatment would not be onerous.
Dr. Lane: This trial would find out if the benefit of T-cell expansion with IL-2 is enough to warrant the cost and trouble, and the side effects.
ATN: Is such a trial likely?
Dr. Lane: I believe we are going to do it -- but am not yet entirely sure of all the researchers and organizations who will be there when we start. A group of European and U.S. investigators who have expressed strong interest in such a trial will be at a meeting in mid June to make some final decisions on a draft protocol for review by the entire group. Hopefully at a meeting of the CPCRA (NIAID's Community Program for Clinical Research on AIDS) in July, we will come to final decisions on the protocol. In addition to the CPCRA and intramural NIAID, a consortium of European and Australian investigators, and the Canadian trials network, are currently part of this effort. My hope is that we will build the support close to a critical mass, and then get the additional help that we need so that this trial can happen.
The data are quite solid. The clinical data we have fit with the immunologic data. The viral levels certainly have not been going up in the randomized study. Our knowledge of many of the immunological and virological subtleties is in place as well.
[Note: An earlier clinical trial in 60 patients(3) found that when IL-2 was added to an antiretroviral regimen for 12 months, the average CD4 count increased from 428 to 916. In the control group with the same treatment except for the IL- 2, the average CD4 count fell from 406 to 349. But this trial was too small to show whether or not increasing the CD4 count in this way was beneficial to patients. In the long-term followup of this cohort there have been seven patients with AIDS-defining events among the patients originally randomized to the control arm, compared to two AIDS-defining events among the patients originally randomized to IL-2.]
1. Connors M, Kovacs JA, Krevat S, Gea-Banacloche JC, Sneller MC, Flanigan M, Metcalf JA, Walker RE, Falloon J, Baseler M, Stevens R, Feuerstein I, Masur H, and Lane HC. HIV Infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. NATURE MEDICINE May 1997; volume 3, number 5, pages 533-540.
2. Davey, Jr., RT, Chaitt DG, Piscitelli SC and others. Subcutaneous administration of interleukin-2 in HIV-1 infected individuals. JOURNAL OF INFECTIOUS DISEASES 1997; volume 175, number 4, pages 781-789.
3. Kovacs JA, Vogel S, Albert JM, and others. Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus. NEW ENGLAND JOURNAL OF MEDICINE October 31 1996; volume 335, number 18, pages 1350- 1356.
Viral Load in Clinical Trials: FDA Advisory Committee Meeting July 14-15, 1997
An important public meeting on using sustained changes in viral load as a substitute for clinical endpoints in certain trials of antiretroviral drugs will be held July 14 and 15 near Washington, D.C. The FDA's Antiviral Drugs Advisory Committee will meet from 8:30 a.m. to 5:00 p.m. each day in Room 204 of the Armory Place, 925 Wayne Avenue, Silver Spring, Maryland. (On July 16 the Advisory Committee will also meet at the same time and place, but on a separate topic -- approval of AmBisome® liposomal amphotericin B as empirical therapy for presumed fungal infection in febrile, neutropenic patients.) All three days of meetings are open to the public.
Persons who want "to participate in the open public hearing or to submit data, information or views to the committee" may do so during a public hearing scheduled for July 14 from 11 a.m. to noon. Those who want to speak should notify Rhonda Stover or John Schupp, at the Center for Drug Evaluation and Research (HFD-21), Food and Drug Administration, 301/443- 5455, or by fax at 301/443-0699, by July 7.
The Armory Place is near the Silver Spring Metro stop. Long- term metered parking is available at Fenton Street and Pershing Drive (payable with quarters only), and there is other parking in the area.
If there are any changes to the meeting schedule, they will be announced on the FDA Advisory Committee Hotline, 800/741- 8138 or 301/443-0572. The 5-digit code number for information about the Antiviral Drugs Advisory Committee is 12531.
Meetings Calendar, June 1997 - 1998
The following list includes research conferences (where new scientific information will be presented), plus selected other meetings that may interest our readers. We have not included invitation-only conferences.
If you know of other meetings that should be on this list, please let us know.
June 1997
** New Perspectives in Treatment: Eradication, Suppression, & Lifelong Adherence: Where Are We? June 14, Cambridge, Massachusetts. Contact: New England AIDS Education and Training Center, 617/566-2283.
** HIV Treatment in the New Millennium: Is HIV Eradication Possible, June 18, New York. Contact: Saint Vincents Education & Training Department, Max Vaval or Andrew Boreland, phone 212/228-8000 x243 or x231.
** Fourth International Symposium on Clinical Immunology, June 19-22, Amsterdam, The Netherlands. Contact: Conference Secretariat, Fourth International Symposium on Clinical Immunology, Amsterdam RAI-OBA, P.O. Box 77777, 1070 MS Amsterdam, The Netherlands. Web site: http://www.rai.nl/congress/cic/en/welcome.html.
July 1997
** FDA Antiviral Drugs Advisory Committee, July 14-15, also July 16, Silver Spring, Maryland. Contact: FDA, 301/443-5455. (See separate announcement in this issue.)
** AIDS Clinical Trial Group (ACTG), July 19-22, Washington, D.C. Contact: NIAID, 301/496-8215.
August 1997
** HIV/AIDS in Cuba: Building Bridges, Crossing Borders, August 6-13, Havana, Cuba. Contact: U.S.- Cuba Medical Project, One Union Square West, Suite 211, New York, NY 10003. 212/727-3247, fax 212/727-3265, email firstname.lastname@example.com .
** National Black Nurses Association, 25th Institute and Annual Conference, August 7-10, New York, NY. Contact: NBNA, 1511 K Street NW, Suite 415, Washington, D.C. 20005; 202/393- 6870, fax 202/347-3808.
** The 15th Annual Symposium of the Gay & Lesbian Medical Association, August 21-23, San Francisco, California. Contact: GLMA Symposium, 459 Fulton St., Suite 107, San Francisco, CA 94102; 415/255-4547, fax 415/255-4784, email firstname.lastname@example.com, web site http://www.glma.org.
** Clinical Care of the AIDS Patient: Summer Symposium, August 21-26, Sun Valley, Idaho. Contact: Department of Medicine at the University of California San Francisco, School of Medicine, 415/476-5208, web site http://cme.ucsf.edu/.
September 1997
** A Conference on Global Strategies for the Prevention of HIV Transmission From Mothers to Infants, September 3-6, Washington, D.C.
Logistics and abstract submission: Contact Ms. Andrea Hall, Social & Scientific Systems, Inc., 7101 Wisconsin Ave., Suite 1300, Bethesda, MD 20814-4805; 800/749-9620 (U.S. calls only), 301/986-1216 (dedicated meeting phone number), 301/986-4870 (accepts collect calls from outside the United States for "Global Strategies Conference" between 9:00 a.m. and 5:00 p.m. Eastern time), fax 301/913-0351, email email@example.com. (Dates: Early registration by July 3 receives discount. Abstracts due by June 27, late-breaking research by August 15.)
Scientific Program: Contact Arthur Ammann, M.D., 415/451- 1814, fax 415/456-2622, email email@example.com.
** Community Programs for Clinical Research on AIDS (CPCRA), September 4-5, Washington, D.C. Contact: Elaine Allison, CPCRA Operations Office, 301/230-9670, fax 301/230-7190, email email@example.com.
** AIDS, Medicine and Miracles: 10th Annual HIV Conference Retreat, September 4-7, Phoenicia, New York. Contact: AIDS, Medicine and Miracles, 800/875-8770, email email@example.com.
** HIV-1 Infection, Mucosal Immunity & Pathogenesis, September 11-13, Natcher Conference Center, National Institutes of Health, Washington, D.C. Contact: Mr. Fred Hill, Conference Manager, HIV-1 Infection, Mucosal Immunity & Pathogenesis, c/o ComputerCraft Corporation, 6707 Democracy Blvd., Suite 101, Bethesda, MD 20817; 301/493-9674, fax 301/530-0634. (Registration Deadline: August 1, 1997; due to space limitations, early registration is encouraged.)
** International Congress on Biomedical Peer Review and Global Communications, September 17-21, Prague, Czech Republic. Contact: Annette Flanagin, American Medical Association, 515 N. State St., Chicago, IL 60610; 312/464- 2432, fax 312/464-5824.
** United States Conference on AIDS, September 18-21, Miami Beach, FL., sponsored by the National Minority AIDS Council (NMAC) Contact: Conference Registrar, The United States Conference on AIDS, 1931 13th St. NW, Washington, D.C. 20009- 4432; 202/483-6622 x313, fax 202/483-1127.
** 37th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), September 28- October 1, Toronto, Ontario, Canada. Contact: American Society for Microbiology (ASM), Meetings Department, 1325 Massachusetts Ave. NW, Washington, D.C. 20005-4171; 202/942- 9356, fax 202/942-9340. [Comment: ICAAC is likely to be important this year, because in odd-numbered years there is no International Conference on AIDS (now named World AIDS Conference) to draw research presentations away. Note: Future ICAAC meetings have been scheduled for September 1998 in San Diego, and September 1999 in San Francisco.]
October 1997
** 6th European Conference on Clinical Aspects and Treatment of HIV Infection, October 11-15, Hamburg, Germany. Contact: K.I.T. GmbH, Kingress und Incentive-Organisation, Karl- Liebknecht Strasse 5, D-10178 Berlin, Germany; +49 30 2382 6900, fax +49 30 2382 6940, email email@example.com , web site: http://www.kit.de.
** Sixth Regional Symposium on the Design & Methods of Clinical Trials, October 17-18, San Francisco. Contact: Office of Continuing Medical Education, University of California, San Francisco, 415/476-5808 to register, 415/476- 4251 to receive a brochure when it is available.
** International Congress of Sexually Transmitted Diseases, October 19-22, Seville, Spain. Contact: International Congress of STD, Apartado 6077, 41080 Seville Spain; +34 5 4903409, fax +34 5 4377413. Or, HCC/ICSTD, One Bridge Plaza, Suite 350, Fort Lee, NJ, 07024, 201/947-5545, fax 201/947- 8406.
** 3rd Annual Conference: A Time for Healing--Women and HIV, October 22-24, Las Vegas, NV. Contact: Pat Stachewicz or Marlo Tonge, 702/383-1397.
** 4th International Congress on AIDS in Asia and the Pacific, October 25-29, Manila, Philippines. Contact: Secretariat, 2nd Floor, Physicians' Tower, 533 United Nations Ave., Ermita, Manila 1000, Philippines; +63 2 526-8103, or +63 2 526-8105, fax +63 2 522-1090 or +63 2 522-8130, email firstname.lastname@example.com, web site http://www.hain.org/ aidsphil.html.
November 1997
** GNP 8th International Conference for People Living with
HIV/AIDS, November 5-12, Chiang Mai, Thailand. Contact:
GNP/ICW Conference Secretariat, 12/14 Rajchiangsaen Road,
Soi 2 Kot, Haiye, Chiang Mai 50100, Thailand, phone 53 206 760,
fax 53 206 761, email firstname.lastname@example.com;
Or, Conference Secretariat, Bangkok, +66 2 526 8311, fax +66 2
968 8021, email firstname.lastname@example.com. Or, GNP+ central
Secretariat, Amsterdam, +31 20 689 8218, fax +31 20 689 8059,
email email@example.com. Or, ICW Secretariat, London, +44 171
222 1333, fax +44 171 222 1242, email firstname.lastname@example.com.
** Tenth Annual Association of Nurses in AIDS Care Conference, November 6-9, Miami Beach, FL. Contact: ANAC Tenth Annual Conference, 11250 Roger Bacon Dr., Suite 8, Reston, VA 20190-5202; 800/260-6780.
** National AIDS Treatment Advocates Forum, November 9-12, San Diego, CA. Contact: David Barre, NATAF Registration, c/o National Minority AIDS Council, 1931 13th Street NW, Washington, D.C. 20009; 202/483-6622 x327, fax 202/483-1135, email firstname.lastname@example.com
** Healthcare Resource Allocation for HIV/AIDS and Other Life-Threatening Illnesses, November 10-11, Washington, D.C. Contact: Paul Rathe, International Association of Physicians in AIDS Care, 312/419-7074, fax 312/419-7079, email email@example.com .
** International Conference on AIDS Wasting, (title may change), November 16-19, Ft. Lauderdale, Florida. Contact: IFARA (International Foundation for Alternative Research on AIDS), 954/630-8002.
December 1997
** Clinical Care of the AIDS Patient, December 4-6, Palace Hotel, San Francisco. Contact: University of California San Francisco, Department of Medicine, Postgraduate Programs, Box 0656, San Francisco, CA 94143-0656; phone 415/476-5208, web site http://cme.ucsf.edu/ .
** AIDS Clinical Trial Group (ACTG), December 5-10, Washington, D.C. Contact: NIAID, 301/496-8215.
** Xth International Conference on AIDS & STD in Africa, December 7-11, Abidjan, Cote d'Ivoire. Contact: Programme National de Lutte contre le SIDA les MST et al Tuberculose, 04 BP 2113, Abidjan 04, Cote d'Ivoire; +225 243013, or +225 243014, or +225 244306, fax +225 243119, web http://www.us.unaids.org/lowband/events/abidjan/introduction. html
** T Lymphocyte Activation, Differentiation and Death, January 26-February 1, Keystone, Colorado. Contact: Keystone Symposia, Drawer 1630, Silverthorne, CO 80498; 800/253-0685 or 970/262-1230, fax 970/262-1525, email email@example.com, web site http://www.colorado.net/symposia .
** 5th Conference on Retroviruses and Opportunistic Infections, late January or early February, 1998. In previous years this conference has been held in Washington D.C., but other cities are now being considered.
** Molecular Aspects of Viral Immunity, February 16-22, Tamarron, Colorado. Contact: Keystone Symposia, Drawer 1630, Silverthorne, CO 80498; 800/253-0685 or 970/262-1230, fax 970/262-1525, email firstname.lastname@example.com, web site http://www.colorado.net/ symposia.
** Cell and Molecular Biology of Dendritic Cells, March 7-13, Santa Fe, New Mexico. Contact: Keystone Symposia, Drawer 1630, Silverthorne, CO 80498; 800/253-0685 or 970/262-1230, fax 970/262-1525, email email@example.com, web site http://www.colorado.net/ symposia.
** HIV Pathogenesis and Treatment, March 13-19, Park City, Utah. Contact: Keystone Symposia, Drawer 1630, Silverthorne, CO 80498; 800/253-0685 or 970/262-1230, fax 970/262-1525, email email@example.com, web site http://www.colorado.net/ symposia.
** Angiogenesis and Vascular Remodelling, March 28-April 3, Steamboat Springs, Colorado. Contact: Keystone Symposia, Drawer 1630, Silverthorne, CO 80498; 800/253-0685 or 970/262- 1230, fax 970/262-1525, email firstname.lastname@example.com, web site http://www.colorado.net/ symposia.
** TB: Molecular Mechanisms and Immunologic Aspects, April 2- 8, Keystone, Colorado. Contact: Keystone Symposia, Drawer 1630, Silverthorne, CO 80498; 800/253-0685 or 970/262-1230, fax 970/262-1525, email firstname.lastname@example.com, web site http://www.colorado.net/ symposia. (Note: registration for this conference also allows for attendance at the meeting below.)
** Opportunistic Infections in AIDS, April 2-8, Keystone, Colorado. Contact: Keystone Symposia, Drawer 1630, Silverthorne, CO 80498; 800/253-0685 or 970/262-1230, fax 970/262-1525, email email@example.com, web site http://www.colorado.net/ symposia. (Note: registration for this conference also allows for attendance at the meeting above.)
** 12th World AIDS Conference, June 28 - July 3, 1998, Geneva. Deadline for regular abstract submission, and for scholarship applications, is February 2, 1988. Contact: Secretariat, 94 rue des Eaux-Vives, CH-1207 Geneva, Switzerland; phone +41 22 737 33 44, fax +41 22 700 33 11, email firstname.lastname@example.com, web site http://www.aids98.ch.
** 4th International Congress on Drug Therapy in HIV Infection, November 8-12, 1998, Glasgow, Scotland. Contact: Gardiner- Caldwell Communications Ltd., +44-1625-664000, fax +44-1625-610260.
Copyright 1997 by John S. James.
Permission granted for noncommercial reproduction,
provided that our address and phone number are included
if more than short quotations are used.


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The natural gardens of North Carolina: with keys and descriptions of the herbaceous wild flowers found therein
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2-lipped 3-lobed Anther areas aster base blades blue bracts branches calyx calyx tube carpels chiefly basal coarsely toothed coastal plain color corolla tube dune eastern erect exserted False Family flat-topped Flowers bilateral flowers borne Flowers radial Flowers solitary forest fruit garden grass habitat heads herbaceous herbs hypanthium inflorescence KEY TO SPECIES lance-shaped leaf-blades leaf-blades ovate leaflets leaves alternate leaves opposite Leaves simple linear lobes Lower petal margin narrow nial North Carolina numerous orchid oval ovary peren Perennials perianth petals borne Petals separate Petals united petioles piedmont pine pink pinnate plants pocosin pubescent purplish racemes salt marsh sand sandhills savannah seeds Sepals and petals sessile showy shrub slender spike spreading Spring and summer stamens stem swamp tall terminal cluster trees turkey oak umbels Upland woods upper leaf axils weed white flowers whorled wild flowers wild ginger yellow flowers

subset: commoncrawl


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The Page Hilltop third grade cast of "Good Manners".
"Good Manners" narrator Annika Preston addresses the audience.
Lezlie Walker and Jayden Ndjigue as Sir Gwendolyn and Sir Dancelot try to restore polite behavior to their village in the play "Good Manners"
By Katrina Drew
AYER -- Two classes of budding third-grade thespians delighted the student body of the Page Hilltop School in February with their production of "Good Manners: A Medieval Quest for Polite Behavior." This play, along with 50 other productions, was penned by Bad Wolf Press' John Heath and Ron Fink as a way to incorporate mandated curriculum facts with humor and music.
"Good Manners" was performed by Mrs. Oppenheim and Ms. Boudreau's classes of 8- and 9-year-olds. "We are so proud of our students," Oppenheim said. "They worked so hard over the last few months to put on a show that both entertained and educated the audience."
This dramatic piece was set in the Middle Ages and focuses on a kingdom that has had a wicked spell cast on it. The spell eliminates good manners, and it is up to Sir Gwendolyn and Sir Dancelot to reverse the curse by helping the characters rediscover polite behavior. An alchemist invents hygiene to dispel germs, a black knight inspires the audience to learn to help others, a damsel -- who was not in distress -- teaches to respect people's privacy, an abbot sings the praises of table manners, and a kind-hearted dragon urges people to not name-call because it hurts people's feelings.
Third-grader Annika Preston served as the narrator throughout this journey to restore manners back to the village. "I was a little nervous at first, but then it was really fun," Preston said. Preston's mother, Kathleen, whose older son was in one of Oppenheim's previous annual productions, was impressed with the show.
"I have seen how much Annika and her classmates learned through this process. This is such an invaluable experience for these students."
Page Hilltop Principal Fred Deppe agreed with Preston and was very clearly proud of these students and their teachers. "The grade 3 production of 'character education' plays is an annual tradition that is looked forward to by students and teachers alike," Deppe said. "I, personally, enjoy not only viewing these productions but also being invited to play a small role by the students each year."
Deppe added, "These play productions encompass a variety of skillsets as they align with numerous learning standards. For many of these young students, this is the beginning of a passion for the dramatic arts. What sets these plays apart from many other school-time productions is that they all have a thematic basis in social-emotional learning. The student audience learns positive character skills while enjoying the show."
Oppenheim and Boudreau both wanted to give special thanks and recognition to Mrs. Reeves, Mr. Morandi, Ms. Oliveira, and Ms. Swenson for all of their help and support of "Good Manners." They also extended their gratitude to the Page Hilltop PTO for providing the funding to purchase the play.


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I've got a serious case of bird envy. Turns out there's a Red-tailed Hawk who thinks he's got his own Fifth Avenue penthouse in NYC.
I'd be lucky to catch a cab on Fifth Avenue, let alone perch there long enough to ogle the passersby.
The bird, dubbed "Pale Male," started "raising his young atop a Fifth Avenue high-rise" during the 1990s. Apparently it wasn't enough for "Pale Male" to garner the attention of urban "birdwatchers, movie stars, poets, children, dogs, reporters and celebrities."
He's flying high on the prospect of fame, having already starred in one movie. Naturally it's called "Pale Male." But come Wed, June 15, he'll be spotted near a Scottsdale high-rise as "The Legend of Pale Male" is screened at Harkins Camelview 5 Theatre — where I enjoyed seeing "The Beaver" with my daughter Lizabeth Monday afternoon.
The latest tale of "Pale Male" is one of two films being shown during Audubon Arizona's "9th Annual Nature Film Festival & Silent Auction." Don't expect "Pale Male" to coast in for the event. He doesn't do personal appearances.
I wonder how he feels about sharing top billing with a bunch of hummingbirds. Their film, titled "Hummingbirds: Magic in the Air," will also be shown that evening.
Sounds like a fun way to introduce kids to the magic of film festivals — especially if you couple the evening with reading about "Pale Male" or birds of other feathers.
The Audubon Arizona event kicks off at 5:30pm with a "picnic supper" and silent auction. Organizers promise "one-of-a-kind" items including "unique art, jewelry, restaurant certificates, sporting and cultural events." Also "travel-themed packages, including local resort stay-cations and a thrilling African safari!" Films start at 7pm.
It'll be quite a step up for me, since most of my animal time involves watching nature shows on PBS. Lately I've had great fun getting to know more about birds featured in the BBC "Wild Australasia" and "Wild Caribbean" series. (I remember my mom doing the same thing when she was my age.)
Seating for the film festival is limited, and RSVPs for advance admission are due no later than June 12.
Tickets are just $25 in advance and $30 at the door (if space is still available) — and include the two bird films, a picnic supper, popcorn and soda.
You can pop for a VIP ticket if you'd like to enjoy reserved seating and express auction check-out. VIP tickets are $100, and include a $75 donation to Audubon Arizona.
General admission and VIP tickets can be purchased through Valerie Ramos at 602-468-6470, ext. 103 or email@example.com. They'll be held for you at the door. Unless, of course, part of the "Pale Male" entourage sweeps down to snatch them up for nesting material.
— Lynn
Note: Lizabeth and I both enjoyed "The Beaver," but wouldn't recommend it for children. It's solid storytelling with fine acting and direction. Those who find its premise absurd don't know the power of depression. Watch the credits carefully for a movie-related website with mental health resources.
Coming up: Arizona arts with a Tony Awards® twist?


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Assisted Living
A Place to Call Your Own — With Assistance When You Need It
Benchmark Senior Living is where traditional assisted living is at its best—secure, at ease, pleasant and supportive. From assistance with basic activities of daily living, such as bathing and dressing, to transportation and reminders to take medication, to providing more complex care, we give our residents the help they need and the respect they deserve.
Personalized Care to Meet the Needs of Each Resident
The word "home" means different things to different people, and we understand that. Each resident's individuality is honored, and residents are encouraged to participate in whatever activities are most meaningful to them. We offer different assisted living service plans, and provide care that fits our residents' lifestyles. With our care model, we can adjust our care with the resident's needs in mind.
Contact Benchmark Senior Living
201 Jones Road Suite 300 West Waltham, MA 02451
Live Now, Live Well™ for Fun and Fitness
At Benchmark Senior Living we help every resident stay well, live well, and be well. Our calendar of programs and events centers on promoting wellness and providing residents plenty of opportunities to learn, socialize, exercise, create and explore. Guided by our award-winning Live Now, Live Well Program and supported by our Resident Care Associates, residents can get the support they need to connect and stay engaged.
Inspired Dining with a Seasonal Flair
Benchmark Senior Living takes a dedicated approach to providing every resident with a personalized dining experience. Our Dining Services Directors and Chefs meet with residents to discuss and understand their dietary needs, special requests, and favorite recipes. Residents can select from an assortment of menu choices designed with their health, tastes and preferences in mind. As the seasons change, we offer variety by providing new and seasonally inspired choices.
Traditional Assisted Living
- Assistance with activities of daily living, including physical and mobility
- Live Now, Live Well wellness program for enhancing health and quality of life
- Personal Care Plans based on individual needs
- Parallel Programming, the option to choose from personal and group activities every hour
- Leadership Presence Model, with management onsite 7 days a week
- Family and Community Support Groups, forums, events and education
- Medication Assistance


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This resource is no longer available
Benefits of a Cloud-based Security Provider
Between an evolving threat landscape and complex regulatory requirements, the need for effective messaging security has never been higher. Unfortunately, common appliance and software security solutions are proving inadequate and ineffective for securing email, Web, and instant messaging (IM) communications.
This resource describes how a cloud-based approach to messaging security can provide comprehensive protection. Read on now to learn solution benefits and more.


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Barham Wedding
Kendal Layne Adams of Big Spring and Casey Barham of Archer City exchanged vows March 23, 2013, at Trinity Baptist Church in Big Spring. Kendal is the daughter of Ricky and Patti Adams of Big Spring and the granddaughteer of Sonya Swindell of Big Spring. She is a Speech-Language Pathologist at United Regional Hospital. Casey is the son of Charlie and Deniese Barham and the grandson of Joyce Barham and Donna Williams. He is a petroleum engineer. Maid of honor was Haley Lefever of Big Spring. Bridesmaids were Brennan Bailey, Christi Jones and Heather Vassar, all of Big Spring and Alyssa Campbell and Kalli Donaway, both of Abilene. Best man was Riley Barham of Archer City. Groomsmen were Ty Robertson and Caleb Truette, both of Archer City and Justin Swinhoe and Jordan Teel, both of Wichita Falls. Ushers were: Kyle Campbell of Wylie, Shelby Lefever, Landon Adkins and Kyle Piercefield, all of Big Spring. Ellorie Jones was Jr. Bridesmaid and Brooks Jones was Jr. Groomsman. The couple spent their honeymoon in Jamaica.


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Changes made from version 2.60 to 2.70:
* Added one second recording setting. Located at Menu -> Settings -> Bike Settings -> Data Rec. -> Data Recording.
* Fixed issue causing ANT sensors to not pair as expected when switching between bike profiles.
* Fixed display issues while editing %FTP, %HRR, and %HR Max in a workout step.
* Fixed a display issue with the elevation value in a saved elevation point.
Changes made from version 2.10 to 2.20:
* Added setting to turn on 1 second recording in Settings > System > Data Recording.
* Fixed an issue that could cause large jumps in position and distance.
* Added Last Lap Power data field.
* Fixed an issue that was causing ANT sensors to not pair as expected.
* Added a setting to enable a prompt to recalculate during navigation.
* Courses are now usable with GPS turned Off and a connected ANT+ Speed sensor.
* The Virtual Partner can now be manually synchronized by pressing and holding on the Virtual Partner graphic.
* Fixed a speed zone field display issue.
* Improved course navigation.
* Fixed issues viewing an activity in progress from the history menu.
* Fixed issue with some Mac users not being able to connect to device without resetting the timer.
* Fixed some display issues when using a weight scale.
* Fixed an issue that could cause distance to not accumulating after switching bike profiles while the timer is running.
* Fixed a few issues while editing workouts and a display issue while doing a workout in night mode.
* Fixed a display issue while doing a workout in night mode.
* Improved elevation calibration when manually setting device elevation.
I have noticed two issues with v2.70 which did not occur in prior firmware releases:
1. The Edge 500 no longer remembers the ANT+ id of my Heart Rate Strap. Instead it will synch with any close HRM, rather than the paired HRM.
See Garmin Forum Post https://forums.garmin.com/showthread.ph ... #post88669
2. The Edge 500 has twice not computed calories for my activities. All other recording has been correct (trackpoints, CAD, HRM, Speed, Distance, Power). This has never happened prior to v2.70.
See Garmin Forum Post https://forums.garmin.com/showthread.ph ... #post88846
Changes made from version 2.70 to 2.80:
* Fixed issue causing multiple heart rate monitors to be found.
* Fixed a speed display issue in history, speed zone setup, and workouts.
Users browsing this forum: No registered users and 2 guests


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Metallica will perform at 2013's Summer Sonic festival in Japan. The band will headline the event on August 10 in Tokyo and will close the proceedings on August 11 in Osaka. Metallica last played Summer Sonic in 2006.
And in a new interview with Classic Rock magazine, Lars Ulrich says Metallica's upcoming 3D movie will combine concert footage with a fictional storyline. Ulrich cites the 1976 Led Zeppelin movie The Song Remains the Same as a major influence, explaining, "There are four members in Led Zeppelin, four members in Metallica, it's a full-length movie, and there's a lot in this film that does not take place onstage. The major difference is that the stuff that takes place offstage in the Metallica movie does not feature any members of Metallica. It's two separate worlds — a Metallica show and a story that unfolds in a parallel universe — and at some point they intertwine."
The movie has no title as yet. Ulrich says, "It's sort of fun, it's intimidating… it's a little overwhelming, to be honest, because it's a whole different league."


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Nature at 6 pm Sunday takes viewers into the secretive world of the largest and least known member of the weasel family to reveal who this dynamic little devil truly is in "Wolverine: Chasing The Phantom".
Call The Midwife at 7 pm Sunday and 9 pm Saturday witnesses the snatching of a baby girl recently delivered by Jenny, causing great anguish to her family and uniting the local community as they search for the missing child.
On Masterpiece Classic Presents: Upstairs Downstairs, Series 2 at 8 pm Sunday, Blanche comes face-to-face with her former lover when a scandalous novel is published while Beryl's decision to take a stand causes serious disruptions in the running of the house.
PBS Newshour at 8 pm Monday presents coverage of the 2012 presidential debates.
Cuban Missile Crisis: Three Men Go To War at 7 pm Tuesday tells the inside story of the Cuban Missile Crisis, exploring how in October 1962 the earth teetered on the very brink of nuclear holocaust.
Secrets of the Dead at 8 pm Tuesday follows the drama and debate that surrounded the most critical point in the Cold War in "The Man Who Saved The World."
Nature at 7 pm Wednesday explores the world of the snowy owl and takes an intimate look at how these majestic birds survive in one of the most isolated and inhospitable places on the planet in "Magic of the Snowy Owl."
Nova at 8 pm Wednesday attempts to unravel more mysteries from Otzi the Iceman than ever before, revealing not only the details of the ancient mummy's death, but an entire way of life in "Iceman Murder Mystery."
Nova ScienceNow at 9 pm Wednesday explores the lives of people stretching the boundaries of what the human mind can do in "How Smart Can We Get?"
Evan talks with performance artist and musician Laurie Anderson on Overheard at 7 pm Thursday.
Arts in Context at 7:30 pm Thursday profiles local Austin music-makers Mother Falcon.
Meet some of the innovators who've helped make Austin the nation's third largest video game production community on Capital Innovation at 8 pm Thursday.
Chet goes on the "best little day trip in Texas" to paddle the Colorado River, explore Texas Czech culture, eat at a 100 year old BBQ joint, and enjoy some kolaches from Hruska's on The Daytripper at 8:30 pm
Add some punch with standout perennials that stand up to weather swings on Central Texas Gardener at noon Saturday. On tour, see how a gardener sliced out lawn for perennials that thrive in watering restrictions.
American rock n' roll dominates the stage with Dr. Dog followed by The Shins' indie pop eloquence on Austin City Limits at 7 pm Saturday.


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The Estee Lauder Companies Cosmetic Beauty Sales-Estee Lauder (SPANISH FORT) in Spanish Fort, Alabama
Cosmetic Beauty Sales-Estee Lauder (SPANISH FORT)
Spanish Fort,AL
Looking for trendsetters seeking a unique opportunity to become part of an elite team of skin care specialists and makeup artists who will service Estee Lauder.
Estee Lauder Beauty Advisor -Part time positions available!
Responsibilities for Cosmetic Beauty Sales:
• Attract new clients with trendsetting image
• Create an amazing experience for all clients with exemplary custom service
• Assist in planning and execution of events
• Flexible retail schedule including days, nights and weekends
• Execute Estee Lauder's signature services including skin care and makeup application
• Recruit clients within the store
• Achieve all sales goals
• Attend all training and development opportunities
Qualifications for Cosmetic Beauty Sales:
• Highly skilled makeup artist
• Experience with skin care application
• Strong Selling Skills
• Goal Oriented
• Fun and Outgoing personality
If this sounds like you, please read the directions below to apply:
After clicking the application link, you will be prompted to complete a registration page. Please enter the following:
Estee Lauder Companies Brand
Select preferred brand - ESTEE LAUDER
What prompted you to this site?
Select Job Posting
Please include referral name or ad code
Enter RT 999cp
Continue with the registration and complete application.
The site supports; Internet Explorer 10, Firefox, Chrome and Safari
Brand Estee Lauder
Job Ref: RT 999cp


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You have no items in your cart.
Availability: In stock
Call us at 888.807.1900
The Zeiss Compact Prime CP.2 35mm/T2.1 Cine Lens for EF Mount is a second generation lense that continue to provide cinema lenses to full-frame DSLRs. What manes this lens a greater value is the interchangable camera mount. So whether you need a EF or F mount for your primary shooter, this camera lense will have your back. Zeiss continues to create the best possible solution for filmmakers and amatuers by providing a lightweight and versatile accessory to your arsenal. The 35mm Compact Prime CP.2 lensesメ improved functionality means improved ergonomics compared to standard SLR lenses, standard housing dimensions, standard focus and iris gear positions, a consistent front diameter, a robust construction,longer focus rotation and a manual focus, thereby providing the flexibility users demand. With precision and speed - Compact Prime CP.2 lenses are the perfect tool for Independent filmmakers, professional still photographers expanding their services or large studios using HDSLRメs as a second camera for TV and feature film productions.
General Features:
Copyright © 2017 Filmtools, a Magnasync/Moviola Company.
Add items to your cart. Go to the shopping cart page and click "Request a Quote". Fill in your information and submit your quote
Send an email with the item or items you want quoted to email@example.com or call us at 888.807.1900.
For expendables please download our spreadsheet HERE and send it to email@example.com


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R.B.I. Baseball (Tengen/NES, 1988)NES saw its fair share of great baseball games, but nothing could top R.B.I. Baseball. With its undemanding yet entertaining gameplay, it was hard to resist. We'll see this series return this month, courtesy of MLB's game publishing division, but will it be able to live up to its legacy?
BaseWars (Ultra Games/NES, 1991)Why play baseball with humans when you can play baseball with robots? Ultra's BaseWars offered a futuristic slant on America's game, with droids hitting fast balls, and actually fighting to take control of bases. This one's still a lot of fun to play, especially if you have a powerhouse team that can blow the opponents into metal rubble.
Super Baseball 2020 (SNK/Neo-Geo, 1993)Ultra wasn't the only studio that could do futuristic baseball right. SNK also nailed it out of the park with Super Baseball 2020, a game featuring a huge variety of characters, as well as plenty of exciting gameplay, including the ability to use power-ups, including a guaranteed home run.
Baseball Stars 2 (SNK/Neo-Geo, 1992)Speaking of the Neo-Geo, it got a contemporary baseball game as well, following the heels of the original Baseball Stars. Featuring improved gameplay in the outfield, and a great presentation by 90's arcade standards, it was easily a grand slam for avid fans of the sport.
World Series Baseball (Sega/Genesis, 1994)Sega made an impressive baseball debut on the Genesis years before with Sports Talk Baseball, but it improved greatly on the formula with its debut Sega Sports title. Featuring dynamic visuals and strong gameplay that covered every aspect of the sport, it would become a legacy for the company for years to come, eventually concluding on the Sega Saturn.
3D Baseball (Crystal Dynamics/PlayStation, 1996)The 90s were a good decade for Crystal Dynamics, after it moved away from 3DO development in favor of PlayStation and Sega Saturn. There, it managed to make a number of classics, including 3D Baseball. What this sim lacked in official licensing, it made up for with great, contemporary visual design and solid gameplay. It's still a good game by today's standards.
MVP Baseball 2005 (EA Sports/PlayStation 2 & Xbox, 2004)Before 2K exclusively scooped up the license for Major League Baseball, EA Sports made one of the best baseball games in town with MVP Baseball 2005. Featuring a variety of splendid modes to choose from (including Dynasty and Owner's modes), and a "Batter's Eye" technique that made it a cinch to reach a pitcher's throw right down to the plate, it remains an appreciated classic.
All the arcade style, without steroids
MLB Slugfest (Midway/Xbox & PlayStation 2, 2002)Considering the popularity of NBA Jam and NFL Blitz, it was a bit surprising that it took so long for baseball to get a turn on the arcade-style front. However, Midway filled the void with MLB Slugfest, with four games featuring plenty of grand-slam hits, sliding-into-base violence and ridiculous commentary. The best of the series was easily Loaded, which featured an unlockable Sub-Zero and Scorpion of Mortal Kombat fame.
Redefining the grand slam
The Bigs (2K Sports/Xbox 360 & PlayStation 3, 2007)Where Slugfest left off, The Bigs easily picked back up. 2K Sports attempted to make the most out of its MLB contract with this silly yet entertaining arcade baseball series, featuring plenty of power-up driven gameplay and exciting visuals to separate the sport from the more-serious MLB 2K games. The gamble paid off quite well, leading to the release of a sequel, The Bigs 2, a couple of years later.
Redefining the grand slam
MLB 2K series (2K Sports/Xbox 360 & PlayStation 3, 2006-2013)After getting its start as ESPN Major League Baseball published by Sega, the MLB 2K series would eventually go over to 2K Games, where it would spend numerous years providing baseball fans with plenty of hard-hitting action. The series would eventually get better over the years, with more dynamic pitching and hitting controls and visuals, as well as in-depth features, including a yearly Perfect Game Challenge tournament for a million dollar top prize. Eventually, the series came to a close with MLB 2K13, the final game under 2K's deal with Major League Baseball.
Sony's MLB 14: The Show is ready for its PS4 debut


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I went of a news site and saw "Amanda Bynes to get mental health evaluation." I rarely read any of the dozens of stories about her, and am not a psychologist by any means, but have seen the headlines over and over about her the past many months. Why is the fact that she needs a "mental health evaluation" news to anyone? And why does that get a headline? Why do "news" outlets continue to cover/hound/papparazzi stalk someone who is in obvious trouble, whether it is mental health issues or addiction or whatever it is? Do you think this helps that person or hurts them, or has no effect?
Curious as to other sane people's opinions about this.


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First Day Of My Life by Bright Eyes
eines der schönsten lieder, find ich.
conor oberst ist so wunderbar aufrichtig und seine lieder immer ein bisschen zerbrechlich.
The relaxed-look is just divine.
Good work.
Ich liebe dieses Lied :)ReplyDelete
Love that sweet pic! :)
such a lovely song and a fitting photograph!
where's the shirt from?
this song is beautiful and sweet. i love it. thanks for sharing.ReplyDelete
the t-shirt is from WeekdayReplyDelete
you know Pascal,,, the BIG power of your personal style is.. CHARMING!!
Beny Ricardo Sadewo
Such a great song... love the picture!!!
Your glasses are from Moscot, aren't they? What modell is it? Is it Lemtosh?
Thanks for the answer!
greetings Jakob
just love it,
Pearl xo
I like your style photographic !
Are you in school of photography?
In Switzerland ?
Jakob: Yes!
Johanne Morrison: Thanks! I'm starting photography at the art school of zurich next month.
I've been reading this blog for a while now and I just want to say it's great to see there are people like you in the world. I mean people who dress like that. And where do you get these nice songs from?? is there a secret Myspace that has these amazing bands and singers? :D Are there any negative comments really? I haven't seen and this blog definitely doesn't deserve one.
May you and the readers have a great day!
really like your blog!ReplyDelete
deine lieder sind immer so schön, vielleicht magst du city and colour - the girl
viele grüße!
this has always been one of my absolute favorite songs. :DReplyDelete
TÚ y esa hermosa canción hace que me sienta en las nubes!!
Totalmente PERFECTO <3
so so herzig mein lieber pascal!ReplyDelete
fabulous blog u have, love all the pix.
come follow me xxo
I got married to this song.ReplyDelete


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by Mike Masnick
Wed, Jan 11th 2006 11:38am
- Google Comes Down On The Wrong Side Of The TPP
- iPhone Developer Creates App Criticizing The iPhone; App Is Quickly Pulled
- Leaked HBGary Documents Show Plan To Spread Wikileaks Propaganda For BofA... And 'Attack' Glenn Greenwald
- Publishers Remove 2500 Journals From Free Access In Bangladesh; Put Them Back When People Notice
- Just Weeks After Cutting Off Wikileaks, Amazon Brags About How US Federal Gov't Is One Of Its Biggest AWS Customers?
Reader Comments
Subscribe: RSS
Matt, 11 Jan 2006 @ 12:35pm
No Subject GivenHopefully we can keep this terrible 100% retention idea out of America.
It's sad that it's now required in europe. This just makes the bigger, wealthier ISPs more powerful, so they can stamp on their customers even more.
john, 11 Jan 2006 @ 12:43pm
Re: No Subject GivenI was there, another interesting (terrible) thing he said to Cisco's government relations advisor was that when they start their new investment cycle into new product development, they ought to take into account the EU data retention directive and make their products function accordingly. Quite how he intends to relate that to globlal investment plans I'm not quite sure. He also refused to guarantee that the government wouldn't go further in future demands of data retention policy.
Rikko, 11 Jan 2006 @ 12:54pm
No Subject Given"Our toughest problem is future-proofing, as there will be a massive change in technology. We request that all engage with us," said Clarke.
This line pisses me off more than anything.. They completely disregard the added complexity and cost required for ISPs to archive this data and now make this implication that the ISPs should also be throwing more resources into keeping accessible in the future.
The ISPs should just dump all relevant logs onto DVDs and throw them in a pile. Maybe to be generous they can scribble the date on each one. Let the feds sort it out.
crystalattice (profile), 11 Jan 2006 @ 1:08pm
Why is it the ISP's job?Why do the ISP's have to retain the data? If the gvt. wants the data so bad, then make a law that the ISP's have to provide copies of their data to the gvt. Then the gvt. can pay to store the data.
ISP's shouldn't have to shoulder the burden of an unfunded mandate, especially if there's no proof that it will make a difference.
Phil, 15 Mar 2006 @ 6:15pm
Re: Why is it the ISP's job?Maybe the ISPs should store junk data on the disks, or use some sort of arcane data format which makes it almost impossible to use.
And what would be the situation of someone who used an EU ISP from anothe, non-EU country, which is quite probably possible, at least on dial up
Brewski, 11 Jan 2006 @ 1:13pm
No Subject Given> < I>telecommunications companies and ISPs will have to save information about customers' phone calls and electronic communications for up to two years
Why two years? Why not five? Ten? Forever? Did some genius politico pull this out of their azz?
> ISP's concerns that their economic competitiveness would be affected by having to store data
Technically, not so much. If everyone is burdened with the same costs, it's a*2 = b*2 = c*2
> We combat this by collecting intelligence.
Anyone know how the US's National Security Agency (the famous NSA/No Such Agency) stores all their shizzle in Fort Meade, Maryland?
Brewski, 11 Jan 2006 @ 1:18pm
Re: More...Sorry, another thought popped into my head after I clicked "Submit". (Only enough storage capacity in there for one idea at a time, I guess...)
>businesses that don't already retain data won't have to in the future
Would corporations that do serve up mail internally for their employees also need to store this data? How would the law apply if the company is based outside the UK, but the mail servers are physically in the UK? What if the servers are in the US, but the employees are in the UK? Sounds to me like this would make doing business in the United Kingdom (and the other countries that have this dumbass unfunded mandate in place) expensive.
Andrew Strasser, 11 Jan 2006 @ 3:31pm
Any Govt.You expect any different.... The brits weren't much more supportive. Actually there have been a few Govts. I've tried to get info from and we've seen how easy it is for stuf to disappear if they don't want you to know. You may have a window, but it'll be gone.


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Um, Mr. lawyer, this was a crime not an accident.http://m.azstarnet.com/...touch=true
Posted By 79 pmooney on 01/14/2014 12:45 PM
My take? Mr. Hernandez should have received 5 years and 15 years parole. That last 10 years of his sentence probably will not improve he outcome when he leaves prison and we tax payers eat it to the tune of a 1/4 million $$s. But one of the conditions of parole is that any alcohol will return him to the slammer for a year. And he has to go to AA meetings. Ben
Nah, throw away the key and let the guy rot in prison. The world can do without this pile of crap. No mercy for killers.


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GENEVA – After four years of litigation, Geneva District 304 and embattled former employee Margaret Pennington have come to a settlement, with the district agreeing to pay her $287,000.
The nine-page settlement agreement was released Tuesday following a Freedom of Information Act request filed with the district's attorney, James Petrungaro.
The monetary part of the nine-page settlement covers Pennington's back pay, crediting her with unused sick days and personal days.
The agreement calls for the district to subtract $73,500 from Pennington's settlement and cut a separate check to be sent to pay her attorney, Ruth Major.
The remaining $213,500 is to have all taxes and pension deductions made before it is paid to her. The district also agreed to pay $3,498.76 to the Teachers Retirement Service and health insurance service as the employer's contribution for her earnings, which is included in the total amount.
Through its attorney, the district issued a statement announcing the two sides "have mutually resolved their legal disputes."
Officials referred questions to Petrungaro, who said there was no comment beyond the prepared statement. Pennington's attorney had no comment, and Pennington did not return a voicemail message seeking comment.
All payments to Pennington and her attorney, as well as the district's litigation expenses, were covered by the district's liability insurer, IAG, officials said.
In addition to the settlement cost, the litigation cost to the insurer was about $180,000, according to a Freedom of Information Act request.
Without admitting fault on either side, the settlement agreement states it is a compromise in the interests of avoiding additional litigation costs. Other terms of the agreement include dropping all legal claims and each side not publicly disparaging the other side.
It also requires that evaluation reports and the nonrenewal of her contract be removed from Pennington's employment record with the district. Instead, the district will provide a letter of reference in Pennington's formal personnel file, according to the settlement.
Pennington, who has a Ph.D. in education and 27 years of experience, was principal at Heartland Elementary School for the 2008-09 school year. She was reassigned as coordinator of special projects for the district for the 2009-10 school year, then her contract was not renewed for the 2009-10 school year.
In 2009, Pennington sued the district in federal court, alleging age – she was 52 in 2008 – and gender discrimination and said the district tried to intimidate her from pursuing discrimination complaints.
In a 2011 complaint of age and gender discrimination with the Illinois Human Rights Commission, Pennington, then 54, of Geneva, claimed school officials engaged in a two-year pattern of abuse and humiliation against her, in violation of state and federal law.
A federal judge ruled in favor of the district's motion to dismiss her suit, but gave her leave to file an amended complaint.
The district also sued Pennington in 2011, seeking more than $100,000 in damages on behalf of itself and two assistant superintendents, alleging that Pennington tape-recorded meetings despite being told not to.
In February, Kane County Circuit Court Judge David Akemann dismissed the district's case, saying the state's eavesdropping law is unconstitutional.
The school board voted in September to authorize a settlement with Pennington. The agreement was released after a period of time allowed for the parties to review the terms.


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Linda Haack Worley, 61, of Minburn passed into eternal rest Saturday, Jan. 25, 2014, at her home, surrounded by her beloved family. For Linda, rest was relative. A close friend said it best, "There is a new event coordinator sitting at the right hand of God today."
Born in Emmetsburg April 8, 1952, to parents Bernard and Lavonne Haack, Linda was one of 10 siblings. From the beginning, Linda's life had a foundation of fun. Growing up on the family farm near Cylinder, hard work was always balanced by games, dancing, and singing.
Linda's love of music was later passed down to her own family. Such was the scene even in the final hours of her life.
Linda graduated from Emmetsburg High School. She and H.B. Worley were married June 20, 1970. Linda began a career with Team National after her children were grown.
Linda loved her gardens, traveling, and sunsets, but most of all she loved others. She lived joyfully in all seasons. She left nothing unsaid. She wanted to know, to share, to listen, to dissect, to explore, to help, to guide, to bless, and to encourage at every opportunity. This is a rare blessing. She was a rare person. We thank God we were chosen to experience her.
Survivors include her husband, H.B. Worley; four children, Scott (Tami) Worley of Des Moines, Nicole (Ron) Short of Waukee, Chris (Sally) Worley of Grimes, and Kari (Justin)?Lantz of Urbandale; and seven grandchildren.
Also surviving are her mother, Lavonne Haack of Dallas Center; eight siblings, Sandy (Dan)?Naig of Graettinger, Mike (Terri)?Haack of Coats, KS, Greg (Norma)?Haack of Spencer, Dave (LuAnn)?Haack of Cylinder, Cheryl (Ivan)?Abernathy of Brooksville, FL, Marsha (Dennis Kramer of Alden, Julie (Jan)?Reimann of Leland and Laurie Brewington of Cedar Rapids; and her aunts, uncle, cousins, nieces and nephews.
Linda is preceded in death by her infant brother, John Eugene; and her father, Bernard Haack.
Funeral service was held Friday, Jan. 31, at Point of Grace Church in Waukee. Interment was in Elmwood Cemetery, Minburn.


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NFC pioneer packs in proximity payments
Bling Nation failed in bring in the bling
Having failed to find a business model that worked, the pioneering proximity payment company Bling Nation has stopped processing payments – although it claims the move is temporary while it finds a workable business model.
The pay-by-sticker system was launched in 2009, striking deals with community banks and under cutting credit card processing fees, but despite its involvement in trials by Facebook and PayPal, American Banker tells us that the company just couldn't make enough money and has suspended services while it thinks over its business model.
Bling Nation was interesting in that it eschewed the overwhelming security normally applied to new payment systems, focusing instead on simplicity and usability. A Bling tag is just a sticker, often applied to the back of a cellphone, which responds with a serial number when queried by a custom reader that Bling nation supplied to traders who signed up to the scheme.
The number isn't encrypted, and as the Bling tag is RFID (rather than the cryptographically-secured NFC standard) it is vulnerable to interception and various forms of attack. But Bling reckoned the small-value transactions possible on the pre-paid tag made such an attack unlikely, and sure enough it's not lack of security which has downed Bling.
"We found it was easier to kind of pause and fix [our business model] than try to tweak and fix," the company told American Banker, declining to explain what kind of fix might work.
The company's last attempt to bump revenue, by introducing a Facebook-connected loyalty scheme called FanConnect, fell flat when the merchants declined to get involved: "They wanted to start charging for a loyalty type programme" one of those merchants told American Banker, continuing: "I didn't need to pay them ... for that because I already had my own loyalty program."
FanConnect was later made optional, but the reluctance of merchants to pay someone else to run their loyalty scheme is bad news for some other players who have aspirations in the same space. ®
Sponsored: Minds Mastering Machines - Call for papers now open


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Difference between revisions of "User talk:Gboyers/archive6"
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Thanks for the additions there,I will add more and more to the weapons section.
Thanks for the additions there,I will add more and more to the weapons section.
--[[User:Snake yo!|Snake.]] 22:12, December 3, 2009 (UTC)
--[[User:Snake yo!|Snake.]] 22:12, December 3, 2009 (UTC)
Revision as of 22:51, 3 December 2009
To leave a message, please Reply Here.
- Use : at the start of all your lines to indent your replies to someone else, like this line.
- Also, Use four tildes (~~~~) to sign your name with the date, like this - Xenon 18:52, 29 July 2006 (BST)
For previous discussion, see: /archive, /archive2, /archive3, /archive4, /archive5
Consistency is one of the policies on the Wiki and it is something that people ignore, so I have been going back to renaming the character images, as I had been doing before. The other, 'more useful', things are more likely to be done by other members of staff. It is also something I have no problem in doing at the moment and is a project big enough to keep me going for quite a while, as it is something I would eventually spread to all/most images across the site. And thank you for the welcome back, just started to play GTA San Andreas again and remembered how awesome the series used to be. A-Dust 02:20, December 2, 2009 (UTC)
- Just to say that you might want to think about new staff members. I've updated the Staff page and moved a number of staff to the inactive list. Not sure on who would be suitable, having not been around for a while. As the contributions, over 13,500 so far. A-Dust 02:39, December 2, 2009 (UTC)
I'm glad to the site doing so well after a lot of work has been put in by the community. Another quick question, is there anything we can do about the Social Profiles? They look awful and people tend to message me more than edit my talk page, which makes it difficult to easily see who has sent the message. The way they used to look was fine, so I don't know whether we can get them back that way or not. As for the edits thing, remember: quality over quantity. A-Dust 02:53, December 2, 2009 (UTC)
Thanks for the comment and certainly thanks for telling me how to remove it and the help. I'll try and help with that too,just got to try and use my capture card again haha.
Could i have help on how to add them please?--Snake. 21:56, December 3, 2009 (UTC) Don't worry mate,i found out i guess i should stop being so dumb haha :)--Snake. 21:58, December 3, 2009 (UTC) Thanks for the additions there,I will add more and more to the weapons section. --Snake. 22:12, December 3, 2009 (UTC) I appear to have a problem trying to move pics on edit,it keeps crashing my browser and saying that this application might make windows slower. Do you know why this may be occuring?--Snake. 22:51, December 3, 2009 (UTC)


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The movie Courageous will be shown at 8:30 p.m. May 24 in front of Beekman School. The public is invited to attend and a donation of $5 per person is asked. Bring chairs and blankets and concessions will be available.
Choose the plan that's right for you. Digital access or digital and print delivery.


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Killer spits on Bradford policeman
SMETHPORT -- Unlike some previous court appearances when he drew attention to himself by giggling and making crude remarks, confessed murderer Thomas Paul Haggie sat quietly Thursday and spoke only when questioned by Judge John Pavlock during a 65-minute hearing on a plea agreement.But Haggie's mellow demeanor took a sudden turn for the worse as he was leaving the courtroom in shackles and handcuffs. Just outside the entrance to the courtroom, Haggie without provocation turned his head and spit directly into the right eye of Assistant Bradford Police Chief Mike Ward, who was standing nearby.Ward rushed to a bathroom to douse his eye with water. Haggie was escorted from the courthouse and returned to the McKean County Jail, where he will await sentencing next month for the Bradford murder of a pregnant woman in September 2009.Spitting on a police officer while a prisoner is reportedly a serious crime of assault. McKean County District Attorney Ray Learn said charges may be filed against Haggie even though Haggie won't be able to serve more time in prison for the spitting incident. Haggie is expected to be sentenced next month to two life terms in state prison without the possibility of parole.For more on this story, see the Dec. 17 edition of The Daily Press.


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NORTH KOREA - There was no sign of Kim Jong Il at a closely watched parade Tuesday marking the 60th anniversary of North Korea's founding, and Western officials said the dictator may be gravely ill.
North Korea's state media was silent about his absence from the parade, a relatively low-key ceremony that unexpectedly lacked North Korea's trademark military display. In a broadcast monitored in Seoul, Korean Central Television showed North Korea's No. 2 leader and other officials atop a viewing stand. Kim Jong Il was not shown.
In Washington, a Western intelligence official said there is reason to believe the 66-year-old, known to his people as the "Dear Leader," was gravely ill after he failed to show up at the celebration.
"There is reason to believe Kim Jong Il has suffered a serious health setback, possibly a stroke," the official said.
Another official said rumors and reports of a possible illness were based in part on intelligence gathered by other nations. At her White House briefing, press secretary Dana Perino initially said she had no information on Kim's health.
A senior U.S. official said rumors had been circulating for weeks about Kim's health and his control over North Korea's highly centralized government. That official said the United States has no independent confirmation that Kim is ill. He has not been seen in public for nearly a month.


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(SportsNetwork.com) - The Winnipeg Jets are trying desperately to build some momentum. A road win Wednesday against the Chicago Blackhawks would certainly help in that regard, but first the Jets have to put a recent blowout loss against the defending Stanley Cup champions behind them.
The Jets halted a three-game losing streak with Monday's win against visiting Detroit, but that victory came just two days after Chicago recorded an easy 5-1 triumph in Winnipeg.
Winnipeg did get a good start against the visiting Blackhawks on Saturday, taking a 1-0 lead just over five minutes into the contest, but it was all downhill from there. The Blackhawks scored five unanswered goals, including three in a 4:55 span early in the second period to chase Winnipeg goaltender Ondrej Pavelec from the game.
Saturday's rout marked Chicago's fifth straight win over the Jets, and the second since the franchise moved from Atlanta to Winnipeg prior to the 2011-12 season. Wednesday's contest marks the second stop in Chicago for the Jets since the franchise relocated.
Winnipeg is coming off a 4-2 victory over the Red Wings on Monday. Matt Halischuk scored the winning goal early in the third period to help the Jets win for just the second time in eight games (2-4-2).
Andrew Ladd, Bryan Little and Michael Frolik each posted a goal and an assist for the Jets. Al Montoya stopped 26 shots in the win.
"I thought one of the things we did very well was we got the pucks to the goal line and I thought we put a lot of pressure on their defense, a lot of shots to the net so there was a lot of really good things in that game," said Winnipeg head coach Claude Noel. "I thought a lot of guys had a really good game."
Forward Evander Kane did not play in Monday's win due to a lower-body injury, but was expected to make the trip to Chicago and could return tonight.
Pavelec expects to get back on the horse tonight against the Blackhawks. The Czech netminder is 0-2-2 with a lofty 4.49 goals against average in four career outings versus Chicago.
Corey Crawford, who made 26 saves to help the Blackhawks down Winnipeg on Saturday, is expected to get the call in net for Chicago in tonight's rematch. His start against the Jets last weekend was Crawford's first appearance against the Atlanta/Winnipeg franchise.
Crawford started Sunday's game against Calgary, but he couldn't prevent the Flames from recording a 3-2 overtime decision in the Windy City. Kris Russell scored the game-winner 1:32 into the extra session, beating Crawford with a blistering slap shot from the point.
Patrick Kane had one goal and one assist and Marian Hossa also lit the lamp for the Blackhawks, who had won three in a row before the OT loss. Chicago sent 44 shots on net, but Reto Berra stopped 42 of them to earn an impressive win in his NHL debut.
"We did put pucks at him, but we didn't get enough rebounds and we didn't get enough traffic," Blackhawks head coach Joel Quenneville said. "Certainly, he was pretty good at controlling those rebounds tonight as well."
Crawford turned away 27 shots in the setback.
Despite the OT setback against Calgary, the Blackhawks still only have one regulation loss on home ice this season. Chicago is 5-1-3 at the United Center this season after going 18-3-3 as the host during last year's lockout- shortened campaign.
Winnipeg is 2-3-1 on the road this season and has lost its last two away games in regulation.


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Ch Braeburn's Close Encounter with handler, George Ward
The Terriers always get a good look at Westminster. As a matter of record, Terriers have won BIS 44 times, three times more often than any other group. Wire Fox Terriers have won BIS 13 times, twice as often as the second most successful breed…Scottish Terriers with seven. One of the top winning dogs in AKC history was the 1985 BIS winner, the Scottish Terrier, Ch Braeburn's Close Encounter, who won a incredible 214 all breed Best In Shows.
No one knows Terriers better than this year's Terrier Group Judge, Peter J. Green. Peter Green is one of two people to win BIS both Westminster, which he has done four times, and Crufts, the giant (20,000 dogs plus) British dogo show. He also was the handler of five number one all breed dogs. He judged the FCI World Show in Sweden in 2008 and will judge Best in Show at Crufts in March this year.
CH Efbe's Hidalgo At Goodspice
One of Green's Westminster wins came with the Sealyham Terrier, CH Dersade Bobby's Girl, and 2008's best Terrier, the Sealyham, CH Efbe's Hidalgo At Goodspice, is the winningest one ever, with a lifetime 91 BIS, including four this year. "Charmin", the 2007 AKC/Eukanuba National Championship winner and the 2008 Westminster Terrier Group winner, was bred by Frances Bergeron and is owned by handler Margery Good, Richard Good, and Sandra Middlebrooks.
Last year's Terrier Group runner up and the 2008 number two Terrier is the Scottish Terrier, CH Roundtown Mercedes of Maryscot. "Sadie" won 24 BIS last year and has won two this year. Sadie was bred by Mary O'Neal & Anstamm Kennelss (2008 Terrier Breeder of the Year), is owned by Amelia Musser, and handled by Gabriel Rangel. However, last Sunday, Rangel won a BIS over the number one dog in America, the Giant Schnauzer, CH Galilee's Pure Of Spirit, with a West Highland White Terrier, CH Arbroath's Rosewood Rise 'N' Shine.
CH Hi-Kel Terrydale Soldier of Fortune
The Lakeland Terrier, CH Hi-Kel Terrydale Soldier of Fortune, returns to Westminster hoping to better her breed winning performance last year and the odds are good that "Ranger" will do so. She finished 2008 twelfth over all and third among the Terriers, with 24 BIS. She is well ahead of that pace with five BIS already. Ranger was bred by Maripi Wooldridge & D Hull McIndoe, owned by Carol Dowd & B Dowd & C Ruggle & Terrydale Kennels, and is handled by Scott Sommer.
Westminster is often a coming out party for dogs beginning a national campaign. One such dog is the young Smooth Fox Terrier, CH J'cobe Kemosabe Vigilante Justice, who last month took three out of four rounds with the Sealyham, Charmin, winning three Terrier Groups and a BIS along the way. "Dodger" was bred by William Dalling & Stacy Turner, is owned by William Dalling and Phil & Amy Booth, and handled by Amy.
CH Sanherpinc Paisa
Another new kid on the block is the Welsh Terrier, CH Sanherpinc Paisa, who came out of the classes in December to win the Terrier Group at the Shoreline DFA of Orange County, beating the Scottish Terrier, Sadie. Since that time, she has never looked back winning the group on both days of the Palm Springs, Kennel Club, the country's largest shows and snagging his first BIS She capped off January with her first BIS on 18 January. "Paisa" was bred by Santiago Pinto, is owned by Bruce Schwartz & Larisa Hotchin, and is handled by Terrier expert Wood Wornall.
Next, the Toy Group.


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News Release
Please note: As of January 20, 2017, information in some news releases may be out of date or not reflect current policies.
ETA News Release: [03/08/2012]
Contact Name: Jason Kuruvilla or Dave Roberts
Phone Number: (202) 693-6587 or x5945
Release Number: 12-0446-NAT
US Department of Labor announces availability of $346 million in grants through Senior Community Service Employment Program
WASHINGTON The U.S. Department of Labor today announced the availability of $346 million in grants through the Senior Community Service Employment Program to provide community service-based job training opportunities for unemployed older Americans.
"The job training programs funded through these grants will enhance employment opportunities for seniors through training while also linking them with businesses that are looking for qualified employees," said Secretary of Labor Hilda L. Solis.
The Labor Department anticipates awarding 10 to 20 grants that will serve a total of approximately 35,700 individuals. Eligible grant applicants include nonprofit organizations, federal public agencies, and tribal organizations and consortia. Applicants must have the ability to administer a multi-state program that meets all of the eligibility and responsibility requirements.
The Senior Community Service Employment Program, authorized by Title V of the Older Americans Act, is the only federally-sponsored employment and training program targeted specifically to unemployed, low-income seniors 55 and older. The program has dual goals of promoting community service and helping participants achieve economic self-sufficiency by guiding them into unsubsidized employment, where appropriate. Program participants provide more than 48 million hours of community service to public agencies and nonprofit organizations annually.
The solicitation for grant applications will be published in the March 9 edition of the Federal Register. Both the solicitation and information on how to apply for a grant are available at http://www.doleta.gov/grants/find_grants.cfm.
For more information on the Senior Community Service Employment Program, visit http://www.doleta.gov/seniors.


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I would like to clarify my position. I am not a member of the group "Mayors Against Illegal Guns." Some of their ideas make sense to me, some do not. I did not sign a letter endorsing more restrictive gun control. I might have signed such a letter if I had the time to research it and if I thought the proposed changes were constitutional and if there was benefit to the community, but I didn't.
The actual letter that I agreed to sign (but didn't actually sign, either) was rather innocuous in my opinion, and in any event, my name was listed as Citizen Greer, not Mayor Greer as the writer implied.
I want our existing gun laws to be enforced. I want to close loopholes in the laws that allow convicted criminals to easily purchase firearms and would like to see stiffer penalties for those who choose to disobey our laws and sell weapons to known convicted violent criminals.
I support the Second Amendment and the right our Americans to keep and bear arms. I also support the position of the Supreme Court in District of Columbia v. Heller, which invalidated DC's decades-old handgun ban and firearm storage law.
Challenges to the Second Amendment have been numerous since that ruling in 2008, and the overwhelming majority of those challenges have been rejected by the courts. The courts are finding that sensible gun laws are not just constitutional, but they are critical to keeping our communities safe.
I do not oppose any law-abiding citizen's right to own any gun that they choose. I would like to see gun owners bear more responsibility when a gun they own is used to intentionally injure or kill innocent people, but I have not signed anything proposing that, either.
I agree with 74 percent of NRA members and 87 percent of non-NRA gun owners who, according to a 2012 survey conducted by GOP pollster Frank Luntz, support requiring criminal background checks of anyone purchasing a gun. In addition, 68 percent of the NRA members polled believed concealed permits should only be granted to applicants who do not have prior arrests for domestic violence.
One out of five law enforcement officers slain in the line of duty is killed with assault weapons. I do not wish to see these weapons banned, but I believe we must do more to prevent them getting into the wrong hands and being used to kill innocent people. To say that any law to that end would be unenforceable -- so why bother -- is not a good enough answer.
We can't possible cite every driver that speeds through a school zone, but we have laws that prohibit that and we enforce those laws the best we can. Countless school children are saved every year as a result.
I am not anti-gun, and I am not anti-NRA. I support the Constitution of the United States and all 27 Amendments, not just the ones I like.
God Bless America.
Tony Greer is the mayor of Cañon City.


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Equity Models' Network Launch
Start:20 February 2014
Time:7.00pm - 10.00pm
LocationThe Rag Factory, Shoreditch, London
Download as vCalendar (for Microsoft Outlook etc.)
Are you a professional model who wants to make improvements to the industry? Do you believe that models need a strong collective voice to ensure their fair treatment?
Come to the free Equity Models' Network Launch to have your concerns heard and meet other models who are also passionate about improving the industry. We've also organised a panel discussion titled 'Models Own Image: The ethics of fashion photography' to look at questions of our branding, how our images are used, intellectual property, and how we imagine ourselves.
Pannellists include:
Paul Bevan - London College of Fashion
Charlotte Gush - All Walks Beyond the Catwalk
Eva Fahler - Equity Models Network
Carlos Lumiere - Fashion Photographer
Anne Mannion - Swan Turton LLP, Media and Entertainment Law
Equity's Models Network is dedicated to fair treatment, respect, and dignity in the workplace for all professional models working in the UK. It is a network built by models to give us an independent collective voice in the industry.
Join us for an evening of passionate discussion and networking and get involved in improving our industry! Book your free place
Further details and contact information
Kristin Hamada
Email: email@example.com


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Google's Secure WiFi Access Not So Secure?
from the whoops dept
There's been a lot of discussions going on around Google's release of a VPN solution. It seems like many of the stories have misinterpreted what it is. The press has turned this into a big thing about Google launching WiFi -- which it isn't (well, at least not yet). Google has been offering some free WiFi hotspots for a while already -- so that aspect wasn't new. The only thing that's new is this VPN offering. So, as a security offering, how secure is it? The folks over at Full Mesh/WiTopia took a look and sent us their analysis suggesting "not very" is the best answer. Full Mesh certainly is a biased party, considering that WiTopia offers a competing solution, but assuming the basic claims they're making are true (and it would be pretty easy for someone with the VPN client to check), then this solution really isn't particularly secure -- which is surprising, because it wouldn't have been hard to lock this down much tighter. The basic summary sent in by Feed Mesh is that the VPN uses PPTP instead of SSL. That's not entirely horrible if the PPTP offering is better locked down, but it doesn't appear to be (and SSL would have been a better overall solution no matter what). They're allowing both CHAP and MS-CHAP (v1) which have well known issues (as the Full Mesh guys point out, just check Google for lots of info on the problems with CHAP and MS-CHAP). Finally, they let pretty much everything pass through the VPN, rather than just TCP/IP. These are things that both WiTopia and HotSpotVPN do a much better job with. Obviously, the Google offering is quite beta, so it's possible they'll improve on this, but it's still worth noting that the "secure" part of the "secure" access might be a little misleading at this point.


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STERLING – Whiteside County residents likely will see a request for a 1 percent sales tax increase to support school facilities on the ballot in April – that is, if the Sterling School Board passes a resolution in support of the proposal by Jan. 22.
Three districts already plan to back the measure, Sterling Superintendent Tad Everett told the board Wednesday. Sterling, with its 36 percent of the enrollment in the county, would tip the scale toward a ballot measure.
The Sterling Public Schools would get the lion's share of revenue – more than $1.5 million a year or more than $30 million over the 20-year life of the tax – from a 1 percent sales tax increase, Everett told the board. That would cover what the district typically has bonded out for Health/Life Safety funds every 10 years, he said.
"This is a new revenue source," Everett said. "It takes a large amount of money for us to keep our facilities up and running. ... Assuming we stick with the status quo, every 10 years, we bond $8 million to $10 million of taxpayer money to deal with these ongoing facilities issues, or, with the tax, one thing we could offer the community is some relief from that."
The board will review a detailed list of proposed facilities needs and could vote on a resolution to place the 1 percent sales tax increase on the ballot at its December meeting.
Also Wednesday, the board:
n Discussed the annual school report card. Everett noted that the district, although it did not make adequate yearly progress toward national education standards, continues to make strides, with 81 percent of students meeting or exceeding standards on state tests last year.
n Approved a tentative tax levy of $13.84 million. Finance director Tim Schwingle noted the estimated equalized assessed value of the district decreased 1 percent from last year and the tentative levy increased 1.07 percent over last year. He noted the tax rate decreased 0.81 percent.
n Approved the annual financial audit. Schwingle said the auditors gave the district a clean report, but recommended several measures to increase internal controls, mostly because auditors are coming down more sternly on government organizations as a result of the Rita Crundwell scheme.


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Re: mirror image of a square matrix
- To: mathgroup at smc.vnet.net
- Subject: [mg66333] Re: [mg66318] mirror image of a square matrix
- From: Bob Hanlon <hanlonr at cox.net>
- Date: Wed, 10 May 2006 06:33:18 -0400 (EDT)
- Reply-to: hanlonr at cox.net
- Sender: owner-wri-mathgroup at wolfram.com
mat=Array[a,{4,3}]; Reverse/@mat == Transpose[Reverse[Transpose[mat]]] True Bob Hanlon ---- ravi <rv15i at yahoo.se> wrote: > Let me define the mirror image of a matrix as the operation of flipping > the columns such that the last column becomes the first, the second > last becomes the second and so on. I would like to know if this can be > done simpler than as follows: > > mat=Table[Random[],{n},{n}] > matR=Transpose[Reverse[Transpose[mat]]] > Are there any built in functions for operations like these? > /ravi >