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Silver: Publications
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- Auld, KL., Brown, CR., Casolari, JM., Komili, S. and Silver, PA. Genomic Association of the Proteasome Demonstrates Overlapping Gene Regulatory Activity with Transcription Factor Substrates. 2006. Molecular Cell, 21:861-871. Absract.
- Bachand, F., Lackner, D., Bahler, J., and Silver, PA. Autoregulation of ribosome bio-synthesis by a translational response in fission yeast. 2006. Mol Cell Biol., 26:1731-42. Absract
- Vandegraaff, N., Devroe, E., Turlure, F., Silver, P.A., and Engelman, A. Genetic and biochemical analyses of integrase-interaction proteins lens epithelium-derived growth factor (LEDGF/p75) and hepatoma-derived growth factor 2 (HRP2) in preintegration complex formation and HIV replication. 2006, Virology, in press. Abstract
- Hitchcock, A.L., Kahana, J.A., and Silver, P.A. The uses of green fluorescent protein in yeasts. 2006. Methods Biochem Anal. 47:179-201
- Robinson, M.A., Park, S., Sun, Z.Y., Silver, P.A., Wagner, G., and Hogle, J.M. Multiple conformations in the ligand-binding site of the yeast nuclear pore targeting domain of Nup116p J. Biol. Chem. 2005. Aug 16. Abstract
- Brodsky, A.S., Meyer, C.A., Hall, G., Swinburne, I.A., Keenan, B.J., Liu, X.S., Fox, E.A., and., Silver, P.A. Genomic mapping of RNA Polymerase II reveals sites of co-transcriptional regulation in human cells. Genome Biology. 2005. Jul 15:6(8): R64 Abstract
- McKee, A.E., Minet, E., Stern, C., Riahi, S., Stiles, C.D., and., Silver, P.A. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol. 2005. July 20;5(1):14 Abstract
- Carrol, J.S., Liu, X.S., C.R., Brodsky, A.S., Meyer, C.A., Li, W., Szary, A., Shao, W., Hesterman, E., Geistlinger, T.R., Fox, E.A., Silver, P.A., and Brown, M. Chromosome-wide mapping of estrogen receptor binding reveals long-range combinatorial regulation requiring forkhead proteins. Cell. 2005. July 15;122(1):33-43 Abstract
- Park, S., Isaacson, R., Kim, H.T., Silver, P.A., and Wagner, G. Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites. Structure (Camb) 2005. Jul; 13(7):995-1005. Abstract
- Casolari, J.M., Brown, C.R., Drubin, D.A., Rando, O.J., and Silver, P.A. Developmentally induced changes in transcriptional program alter spatial organization across chromosomes. Genes Dev. 2005. May 15;19(10):1188-98. Abstract
- Schroeder, F.C., Kau, T.R., Silver, P.A., and Clardy, J. The psammaplysenes, specific inhibitors of FOXO1a nuclear export. J Nat Prod 2005. Apr; 68(4):574-6. Abstract
- Devroe, E., Silver, P.A., and Engelman, A. HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. Virology 2005. Jan 5; 331(1):181-9. Abstract
- Hieronymus, H., and Silver, P.A. A systems view of mRNP biology. Genes Dev. 2004. Dec 1,18(23):2845-60.Abstract
- Lu, R., Limon, A., Devroe, E., Cherepanov, P., Silver, P.A., and Engelman, Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a post-nuclear entry step of human immunodeficiency virus type 1 replication. J. Virol. 2004. Dec; 78(23):12735-46.Abstract
- Hieronymus, H., Yu, M.C., and Silver, P.A. Genome-wide mRNA surveillance is coupled to the mRNA export. Genes Dev. 2004. Nov 1; 18(21):2652-62.Abstract
- Silver, P.A. and Way, Jeffrey. The potential for synthetic biology. The Scientist. 2004. Sept. 27; 18(18);30-1. Epub
- Cherepanov, P., Devroe, E., Silver, P.A., and Engelman, A. Identification of an evolutionarily-conserved domain in LEDGF/p75 that binds HIV-1 integrase. J. Biol. Chem. 2004; Sept. 14. Epub
- Turlure, F., Devroe, E., Silver, P.A., and Engelman, A. Human cell proteins and human immunodeficiency virus DNA integration. Front Biosci. 2004; Sept. 1; 9:3187-208. Abstract
- Yu, M.C., Bachand F., McBride, A.E., Komili, S., Casolari, J.M., and Silver, P.A. Arginine methyltransferase affects interactions and recruitment of mRNA processing and export factors. Genes Dev 2004, Aug. 15. 18(16):2024-35. Abstract
- McKee A.E.. and Silver, P.A. REF-ereeing the cytoplasmic fate of mRNA via nuclear export. Dev Cell 2004. July 7; 23(13):2641-50.Abstract
- Bachand, F. and Silver, P.A. PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits. EMBO J 2004. July 7; 23(13):2641-50.Abstract
- Casolari, J.M., Brown, C.R., Komili, S., West, J., Hieronymus, H., and Silver, P.A. Genome-wide localization of the nuclear transport machinery reveals coupling of transcriptional status and nuclear organization. Cell. 2004. May 14; 117(4):427-39.Abstract
- Casolari, J.M. and Silver, P.A. Guardian at the gate: preventing unspliced pre-mRNA export. Trends Cell B iol. 2004. May, 14(5):222-5 Abstract
- Devroe, E., Erdjument-Bromage, H., Tempst, P., and Silver, P.A. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. JBC. April 2, 2004. Abstract
- Devroe, E., and Silver, P.A. Therapeutic potential of retroviral RNAi vectors Expert Opin. Biol. Ther. 2004; 4(3):319-27.
- Kau, T.R., Way, J.C., and Silver, P.A. Nuclear transport and cancer: from mechanism to intervention. Nat. Rev. Cancer. 2004; Feb; 4(2):106-17. Abstract
- Jiang, Y., Minet, E., Zhang, Z., Silver, P.A., and Bai, M. Modulation of interprotomer relationship is important for activation of dimeric calcium-sensing receptor. J. Biol. Chem. 2004. Abstract
- Kau, T.R., Schroeder, F., Ramazwamy, S., Wojciechowski, C.L., Zhao, J.J., Roberts, T.M., Clardy, J., Sellers, W.R., and Silver, P.A. A Chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN deficient tumor cells. Cancer Cell. 2003; 4(6):463-76. Abstract
- Haggarty, S.J., Koeller, K.M., Kau, T.R., Silver, P.A., Roberge, M., and Schreiber, S.L. Small molecule modulation of the human chromatid decatenation checkpoint. Chem. Biol. 2003; 10(12):1267-79. Abstract
- Hitchcock, A.L., Auld, K., Gygi, S.P., and Silver, P.A. A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery. Proc. Nat. Acad. Sci. 2003, 100(22):12735-40.Abstract
- Devroe, E., Engelman, A., and Silver, P.A. Intracellular transport of human immunodeficiency virus type 1 integrase J. Cell. Sci. 2003; 116(Pt21):4401-8. Abstract
- Brodsky, A.S,, Johnston, A.P,, Trau, M., and Silver, P.A. Analysis of RNA-protein interactions by flow cytometry. Curr. Opin. Mol. Ther 2003; 5(3):235-40. Abstract
- Kau, T.R. and Silver, P.A. Nuclear transport as a target for cell growth. Drug Discov. Today. 2003; 8(2):78-85. Abstract
- Hieronymus, H. and Silver, P.A. Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery. Nat. Genet. 2003; 33(2):155-61. Abstract
- Beilharz T., Egan, B., Silver, P.A. Hofmann, K., and Lithgow, T. Bipartite signals mediate subcellular targeting of tail-anchored membrane protein in saccharomyces cerevisiae. J. Biol. Chem. 2003; [epub ahead of print].Abstract
- Damelin, M. and Silver, P.A. In situ analysis of spatial relationships between proteins of the nuclear pore complex. Biophys J. 2002; 83(6): 3626-36.Abstract
- Brodsky, A.S. and Silver, P.A. A microbead-based system for identifying and characterizing RNA-protein interactions by flow cytometry. Mol Cell Proteomics 2002; 1(12): 922-9. Abstract
- Lei, E.P., Stern, C.A., Fahrenkrog, B., Krebber, H., Moy, T.I., Aebi, U. and Silver, P.A., Sac3 is an mRNA export factor that localizes to the cytoplasmic fibrils of the nuclear pore complex. Mol Biol Cell 2002; In Press.
- Lei, E. P. and Silver, P.A. Intron status and 3'-end formation control cotranscriptional export of mRNA. Genes Dev 2002; 16: 2761-2766. Abstract
- Limon A., Devroe, E., Lu, R., Ghory, H.Z., Silver, P.A., and Engelman, A. Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import. J Virol. 2002; 76(21): 10598-607.Abstract
- Devroe, E. and Silver, P.A. Retrovirus-delivered siRNA. BMC Biotechnol. 2002; 2(1): 15. Abstract
- Moy, T.I., and Silver, P.A. Requirements for the nuclear export of the small ribosomal subunit. J Cell Sci 2002; 115 (Pt 14): 2985-95.Abstract
- Damelin, M., Silver, P.A., and Corbett, A.H. Nuclear protein transport. Methods Enzymol. 2002; 351:587-607.
- Brodsky, A..S. and Silver, P.A. Identifying proteins that affect mRNA localization in living cells. Methods 2002; 26(2):151-5.
- Moy, T.I., Boettner, D., Rhodes, J.C., Silver, P.A., and Askew, D.S. Identification of a role for Saccharomyces cerevisiae Cgr1p in pre-rRNA processing and 60S ribosome subunit synthesis. Microbiology 2002; 148 (Pt 4): 1081-1090. Abstract
- Damelin, M., Simon, I., Moy, T.I., Wilson, B., Komili, S., Tempst, P., Roth, F.P., Young, R.A., Carins, B.R., and Silver, P.A. The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress. Mol Cell 2002; 9 (3): 563-73. Abstract
- Lei, E.P. and Silver, P.A. Protein and RNA export from the nucleus. Dev Cell. 2002; 2 (3): 261-72. Abstract
- Valentini, S.R., Casolari, J.M., Oliveira, C.C., Silver, P.A. and McBride, A.E. Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling. Genetics 2002; 160 (2): 393-405. Abstract
- Hitchcock, A.L., Krebber, H., Frietze, S., Lin, A., Latterich, M., and Silver, P.A. The conserved Npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation. Mol Biol Cell 2001; 12 (10): 3226-3241. Abstract
- Lei, E.P., Krebber, H., and Silver, P.A. Messenger RNAs are recruited for nuclear export during transcription. Genes Dev. 2001; 15(14): 1771-1782. Abstract
- McBride, A.E. and Silver, P.A. State of the Arg: Protein methylation at arginine comes of age. Cell 2001; 106(1): 5-8.
- Tham, W., Wyithe, J.S., Ferrigno, P.K., Silver, P.A., and Zakian, V.A. Localization of yeast telomeres to the nuclear periphery is separable from transcriptional repression and telomere stability functions. Mol Cell 2001; 8(1): 189-199. Abstract
- Hood, J.K., Hwang, W.W., and Silver, P.A. The Saccharomyces cerevisiae cyclin Clb2p is targeted to multiple subcellular locations by cis- and trans-acting determinants. J. Cell Sci. 2001; 114 (3): 589-597. Abstract
- Brodsky, A.S. and Silver, P.A. Pre-mRNA processing factors are required for nuclear export. RNA 2000; 6(12): 1737-1749.Abstract
- Colas, P., Cohen, B., Ferrigno, P.K., Silver, P.A., and Brent, R. Targeted modification and transportation of cellular proteins. Proc.Natl.Acad.Sci. USA 2000 Dec 5; 97(25): 13720-13725. Abstract
- Weiss, V. H., McBride, A. E., Kim, H. K., Hogle, J. M., and Silver, P. A. The structure and oligomerization of the yeast arginine methyltransferase, Hmt1. Nat. Struct. Biol. 2000; 7: 1165-1171. Abstract
- Stage-Zimmermann, T., Schmidt, U. and Silver, P.A. Factors Affecting Nuclear Export of the 60S Ribosomal Subunit In Vivo. Mol Biol Cell 2000 Nov;11(11):3777-3789. Abstract
- Krebber, H. and Silver, P.A. Directing proteins to nucleus by fusion to nuclear localization signal tags. Methods Enzymol 2000;327:283-96. Abstract
- Prinz, W.A., Grzyb, L., Veenhuis, M., Kahana, J.A., Silver, P.A. and Rapoport, T.A. Mutants affecting the structure of the cortical endoplasmic reticulum in Saccharomyces cerevisiae. J Cell Biol 2000 Aug 7;150(3):461-74. Abstract
- Hood, J.K. and Silver, P.A. Diverse nuclear transport pathways regulate cell proliferation and oncogenesis. Biochim Biophys Acta 2000 Jul 31;1471(1):M31-41. Abstract
- Shen, E.C., Stage-Zimmermann, T., Chui, P., and Silver, P.A. The yeast mRNA binding protein Npl3p interacts with the Cap Binding Complex. J. Biol. Chem. 2000 May 22. Abstract
- Ferrigno, P. and Silver, P.A. Polyglutamine expansions: proteolysis, chaperones, and the dangers of promiscuity. Neuron 2000 Apr;26(1):9-12. Abstract
- Hood, J.K., Casolari, J.M., and Silver, P.A. Nup2p is located on the nuclear side of the nuclear pore complex and coordinates Srp1p/importin-alpha export. J. Cell Sci. 2000 Apr;113 (Pt 8):1471-80. Abstract
- Jones, A.L., Quimby, B.B., Hood, J.K., Ferrigno, P., Keshava, P.H., Silver, P.A., and Corbett, A.H. SAC3 may link nuclear protein export to cell cycle progression. Proc. Natl. Acad. Sci. USA 2000 Mar 28;97(7):3224-9. Abstract
- McBride, A.E., Weiss, V.H., Kim, H.K., Hogle, J.M., and Silver, P.A. Analysis of the yeast arginine methyltransferase Hmt1p/Rmt1p and its in vivo function. Cofactor binding and substrate interactions. J. Biol. Chem. 2000 Feb 4;275(5):3128-36. Abstract
- Damelin, M. and Silver, P.A. Mapping interactions between nuclear transport factors in living cells reveals pathways through the nuclear pore complex. Mol. Cell 2000; 5: 133-140. Abstract
- Morehouse, H., Buratowski, R.M., Silver, P.A., and Buratowski, S. The importin/karyopherin kap114 mediates the nuclear import of TATA-binding protein. Proc. Natl. Acad. Sci. U.S.A. 1999; 96(22):12542-7.
- Ferrigno, P. and Silver, P.A. Regulated nuclear localization of stress-responsive factors: how the nuclear trafficking of protein kinases and transcription factors contributes to cell survival. Oncogene 1999; 18(45):6129-34.
- Moy, T.I. and Silver, P.A. Nuclear export of the small ribosomal subunit requires the ran-GTPase cycle and certain nucleoporins. Genes & Dev. 1999; 13(16):2118-33.
- Krebber, H., Taura, T., Lee, M.S., and Silver, P.A. Uncoupling of the hnRNP Npl3p from mRNAs during the stress-induced block in mRNA export. Genes & Dev. 1999;13(15):1994-2004.
- Brodsky, A.S. and Silver, P.A. Nuclear transport HEATs up. Nat. Cell. Biol. 1999;1(3):E66-E67.
- Zeng, X., Kahana, J.A., Silver, P.A., Morphew, M.K. McIntosh,J.R.,Fitch, I.T., Carbon, J., and Saunders, W.S. Slk19p is a centromere protein that functions to stabilize mitotic spindles. J. Cell. Biol. 1999;146(2):415-25.
- Defossez, P.A., Prusty, R., Kaeberlein, M., Lin, S.J., Ferrigno, P., Silver, P.A., Keil, R.L., and Guarente, L. Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol. Cell 1999; 3(4):447-55.
- Hood, J.K. and Silver, P.A. In or out? Regulating nuclear transport. Curr. Opin. Cell. Biol. 1999;11(2):241-7.
- Valentini, S.R., Weiss, V.H., and Silver, P.A. Arginine methylation and binding of Hrp1p to the efficiency element for mRNA 3'-end formation. RNA 1999; 5(2):272-80.
- Ferrigno, P. and Silver, P.A. Analysis of nuclear transport in vivo. Meth. Cell Biol. 1999;58:107-22.
- Seedorf, M., Damelin, M., Kahana, J.A., Taura, T., and Silver, P.A. Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase. Mol. Cell. Biol. 1999;19(2):1547-57.
- Hood, J.K. and Silver, P.A. Cse1p is required for export of Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae. J. Biol. Chem. 1998; 273(52):35142-6.
- Silberstein, S., Schlenstedt, G., Silver, P.A., and Gilmore, R. A role for the DnaJ homologue Scj1p in protein folding in the yeast endoplasmic reticulum. J. Cell. Biol. 1998;143(4):921-33.
- Ferrigno, P., Posas, F., Koepp, D., Saito, H., and Silver, P.A. Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1. EMBO J. 1998;17(19):5606-14.
- Finley et al., Unified nomenclature for subunits of the yeast proteasome regulatory particle. TIBS 1998; 23:244-245.
- Taura, T., Krebber, H. and Silver, P.A. A member of the Ran binding protein family, Yrb2p, is involved in NES dependent nuclear protein export. Proc. Natl. Acad. Sci. USA 1998; 95:7427-7432.
- Shen, E.C., Henry, M.F., Weiss, V.H., Valentini, S., Silver, P.A., and Lee, M.S. Arginine methylation facilitates the nuclear export of hnRNPs. Genes & Dev. 1998; 12:679-691.
- Webb, C.D., Graumann, P., Kahana, J.A., Teleman, A., Silver, P.A. and Losick, R. Use of time-lapse microscopy to visualize rapid movement of the replication origin region of the chromosome during the cell cycle in Bacillus subtilis. Mol. Microbiol. 1998; 28:883-892.
- Kahana, J.A., Schlenstedt, G., Geiser, J.R., Evanchuck, D.M., Hoyt, A. and Silver, P.A. The yeast dynactin complex is involved in partitioning the mitotic spindle between mother and daughter cells during anaphase B. Mol. Biol. Cell 1998; 9:1741-1756.
- Huyett, A., Kahana, J., Silver, P., Zeng, X., and Saunders, W.S. Microtubule density controlled by antagonistic kinesin motors. J. Cell Sci. 1998; 111:295-301.
- Vodicka, M.A., Koepp, D.M., Silver, P.A. and Emerman, M. HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. Genes & Dev. 1998; 12:175-185.
- Kahana, J. and Silver, P.A. The uses of GFP in yeast. in GFP: Green Fluorescent Protein Strategies and Applications, ed. by M. Chalfie and S. Kain; John Wiley & Sons, Inc. 1998, in press.
- Scott, H.S., Antonarakis, S.E., Lalioti, M.D., Rossier, C., Silver, P.A., and Henry, M.F. Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). Genomics 1998; 15:330-340.
- Koepp, D. and Silver, P.A. Nucleo-cytplasmic transport and cell proliferation. BBA Reviews in Cancer 1998; 1377:39-47.
- Taura, T., Schlenstedt, G. and Silver, P.A. Yrb2 is a nuclear protein that interacts with Prp20p, a yeast Rcc1 homologue. J. Biol. Chem. 1997; 272:31877.
- Kessler, Henry, M., Shen, E., Zhao, J., Gross, S., Silver, P., and Moore, C.L. Hrp1, an RNA binding protein that shuttles between the nucleus and cytoplasm, is required for mRNA 3' end formation in yeast. Genes & Dev. 1997; 11:2545-2556.
- Lithgow, T., Cuezva, J.M., and Silver, P.A. Highways for delivery to the mitochondria. Trends in Biochemical Sciences 1997; 110-113.
- Corbett, A.H., Koepp, D.M., and Silver, P.A. Indirect immunofluorescence in Saccharomyces cerevisiae. in Cell Biology: a Laboratory Manual ed. by David Spector; Cold Spring Harbor Press, 1997.
- Silver, P.A. Scj1p. in Guidebook to Molecular Chaperones and Protein Folding Catalysts, ed. by M.-J. Gething; Sambrook & Tooze at Oxford University Press, 1997.
- Corbett, A. and Silver, P. Genetic analysis of nuclear transport. Microbiology and Molecular Biology Reviews 1997; 61:193-211.
- Lee, M. and Silver, P.A. RNA movement from the nucleus. Current Opinion in Genetics & Development 1997; 212-219.
- Seedorf, M. and Silver, P. A. Importin/Karyopherin protein family members required for mRNA export from the nucleus. Proc. Natl. Acad. Sci. USA 1997; 94:8590-8595.
- Clarkson, W.D., Corbett, A.H., Paschal, B.M., Kent, H.K., McCoy, A.J., Gerace, l., Silver, P.A., Stewart, M. Nuclear protein import is descreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran. J. Mol. Biol. 1997; 272:716-730.
- Campbell, K.S., Mullane, K., Aksoy, I., Pipas, J.M., Silver, P.A., Roberts, T.M., Schaffhausen, B.S., and DeCaprio, J.A. The J-domain of SV40 large TAg mediates Hsc70 binding and viral DNA replication. Genes & Dev. 1997; 11:1098-1110.
- Wong, D.H., Corbett, A.H., Kent, H., Stewart, M. and Silver, P.A. Interaction between the small GTPase Ran/Gsp1 and Ntf2 is required for nuclear import. Mol. Cell Biol. 1997; 17:3755-3767.
- Kahana, J. and Silver, P. Use of the A. victoria green fluorescent protein to study protein dynamics in vivo. Current Protocols in Molecular Biology 1996; 9.7.22-9.7.28.
- Koepp, D. and Silver, P. A GTPase that controls nuclear trafficking: Running the right way or walking RANdomly? Cell 1996; 87:1-20.
- Corbett, A., Ferrigno, P., Henry, M., Kahana, J., Koepp, D., Lee, M., Nguyen, L., Schlenstedt, G., Seedorf, M., Shen, E., Taura, T. and Silver, P. Genetic analysis of macromolecular transport across the nuclear envelope. (Proceedings from the Nobel Symposium) Exp. Cell Res. 1996; 229:212-216.
- Koepp, D.M., Wong, D.H., Corbett, A.H., and Silver, P.A. Dynamic localization of the nuclear import receptor and its interactions with transport factors. J. Cell Biol. 1996; 6:1163-1176.
- DeHoratius, C. and Silver, P.A. Nuclear transport defects and nuclear envelope alterations are associated with mutation of the Saccharomyces cerevisiae NPL4 gene. Mol. Biol. Cell 1996; 7:1835-1855.
- Henry, M. and Silver, P. A novel arginine methyltransferase (HMT1) modifies a poly(A) RNA-binding protein. Mol. Cell. Biol. 1996; 16:3668-3678.
- Haarer, K., Corbett, A.H., Kweon, Y., Petzold, A.S., Silver, P.A. and Brown, S.S. SEC3 mutations are synthetically lethal with profilin mutations and cause defects in diploid-specific bud-site selection. Genetics 1996; 144:495-510.
- Corbett, A.H. and Silver, P. A. The NTF2 gene encodes an essential highly conserved protein that functions in nuclear transport in vivo. J. Biol. Chem. 1996; 271:18477-18484.
- Lee, M., Henry, M., and Silver, P. A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export. Genes & Dev. 1996; 10:1233-1246.
- Henry, M., Borland, C., Bossie, M. and Silver, P. Potential RNA binding proteins in Saccharomyces cerevisiae identified as suppressors of temperature-sensitive mutations in NPL3. Genetics 1996; 142:103-115.
- 1995
- Koepp, D.M. and Silver, P. Rna1p, a GTPase activating protein, plays a direct role in nuclear transport. J. NIH Research 1995; 7:53-54.
- Schlenstedt, G., Wong, D., Koepp, D. and Silver, P. Mutants in a yeast Ran binding protein are defective in nuclear transport. EMBO J. 1995; 21:5367-5378.
- Corbett, A., Koepp, D., Schlenstedt, G., Lee, M., Hopper, A., and Silver, P. Rna1p, a Ran/TC4 GTP-activating protein, is required for nuclear import. J. Cell Biol. 1995; 130:1-10.
- Kahana, J., Schnapp, B. and Silver, P. Kinetics of spindle pole body separation in budding yeast. Proc. Natl. Acad. Sci. USA 1995; 92:9707-9711.
- Loeb, J.D.J., Schlenstedt, G., Pellman, D., Kornitzer, D., Silver, P.A. and Fink, G.R. A yeast nuclear import receptor homologue required for mitosis. Proc. Natl. Acad. Sci. USA 1995; 92:7647-7651.
- Schlenstedt, G., Harris, S., Risse, B., Lill, R. and Silver, P. A yeast DnaJ homologue, Scj1, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interaction with Hsp70s. J. Cell Biol. 1995; 129:979-988.
- Schlenstedt, G., Saavedra, C., Loeb, J., Cole, C. and Silver, P. The GTP-bound form of the yeast Ran/TC4 homologue blocks bi-directional transport across the nuclear envelope. Proc. Natl. Acad. Sci. USA 1995; 92:225-229.
- Flach, J., Bossie, M., Vogel, J., Corbett, A., Jinks, T., Willins, D., and Silver, P.A. A yeast RNA binding protein shuttles between the nucleus and the cytoplasm. Mol. Cell Biol. 1994; 14:8399-407.
- Osborne, M. A., Schlenstedt, G. Jinks, T. and Silver, P. Nuf2, a spindle pole body associated protein required for nuclear division in yeast. J. Cell Biology 1994; 125:853-66.
- Osborne, M. and Silver, P. Nucleocytoplasmic transport in the yeast Saccharomyces cerevisiae. Annual Review of Biochemistry 1993; 62:219-54.
- Silver, P. and Way, J. Eukarytotic DnaJ homologues and the specificity of hsp70 action. Cell 1993; 74:1-3.
- Schlenstedt, G. , Hurt, E., Doye, V. and Silver, P. Reconstitution of nuclear protein transport with semi-intact yeast cells. J. Cell Biology 1993; 123:785-98.
- Kurihara, T. and Silver, P. Suppression of a sec63 mutation identifies a novel component of the ER translocation apparatus. Mol. Biol. Cell 1993; 4:919-30.
- Nelson, M., Kurihara, T. and Silver, P. Extragenic suppressors of mutations in the cytoplasmic C-terminus of Sec63 define five genes in S. cerevisiae. Genetics 1993; 134:159-73.
- Stochaj, U., Bossie, M., van Zee, K. and Silver, P. Analysis of conserved binding proteins for nuclear localization sequences. J. Cell Science 1993; 104:89-95.
- Kurihara, T. and Silver, P. DnaJ homologs and protein transport. in Membrane Biogenesis and Protein Targeting, ed. W. Neupert and R. Lill; Elsevier Science Publishers, 1992; 309-27.
- Bossie, M., Barcelo, G., Dehoratius, C., and Silver, P. A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast. Mol. Biol. Cell 1992; 3:875-93.
- Stochaj, U. and Silver, P. A conserved phosphoprotein that specfically binds nuclear localization sequences is involved in nuclear import. J. Cell Biology 1992; 117:473-82.
- Silver, P. How proteins enter the nucleus. Cell 1991; 64:489-97.
- Blumberg, H. and Silver, P. A yeast protein containing two separated zinc fingers is required for normal cell growth. Gene 1991; 107:101-10.
- Stochaj, U., Osborne, M., Kurihara, T. and Silver, P. A yeast protein that binds nuclear localization sequences: Purification, localization and antibody inhibition of binding activity. J. Cell Biology 1991; 113:1243-54.
- Blumberg, H. and Silver, P. SCJ1, a DNAJ homologue that alters protein sorting in yeast. Nature 1991; 349:627-30.


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==Lindsay Ideson (Northside) ==
==Lindsay Ideson (Northside) ==
*[http://aries.jmrl.org/search/t?discovery+of+witches'''A Discovery of Witches'''] by Deborah Harkness
*[http://aries.jmrl.org/search/t?discovery+of+witches'''A Discovery of Witches'''] by Deborah Harkness
==Russ Lyttleton (Central) ==
==Russ Lyttleton (Central) ==
|Line 47:
|Line 51:
==Gail Ott (Louisa) ==
==Gail Ott (Louisa) ==
*[http://aries.jmrl.org/search/t?paris+wife '''The Paris Wife'''] by Paula McLain.
*[http://aries.jmrl.org/search/t?paris+wife '''The Paris Wife'''] by Paula McLain.
==Heather Pehnec (Central)==
==Heather Pehnec (Central)==
|Line 64:
|Line 71:
*[http://aries.jmrl.org/search/t?emily+alone '''Emily Alone'''] by Stewart O'Nan.
*[http://aries.jmrl.org/search/t?emily+alone '''Emily Alone'''] by Stewart O'Nan.
*[http://aries.jmrl.org/search/X?major+pettigrew's+last+stand '''Major Pettigrew's Last Stand'''] by Helen Simonson.
*[http://aries.jmrl.org/search/X?major+pettigrew's+last+stand '''Major Pettigrew's Last Stand'''] by Helen Simonson.
[[Category:Adult Fiction]]
[[Category:Adult Fiction]]
[[Category:Adult Nonfiction]]
[[Category:Adult Nonfiction]]
[[Category:Personal Picks]]
[[Category:Personal Picks]]
Revision as of 15:36, 31 October 2011
Article in Adult Fiction and Adult Nonfiction and Personal Picks categories.
See what staff are reading (and recommending!)
- 1 Bob Bjoring (Central)
- 2 Anne Chiles (Central)
- 3 Nancy Cook (Central)
- 4 Meredith Dickens (Gordon)
- 5 Krista Farrell (Central)
- 6 Noelle Funk (Scottsville)
- 7 Willow Gale (Bookmobile)
- 8 Gary Grant (Albemarle Trustee)
- 9 John Halliday (Central)
- 10 Holly Huffman (Greene)
- 11 Lindsay Ideson (Northside)
- 12 Rhonda Johnson (Crozet)
- 13 Russ Lyttleton (Central)
- 14 Joyce MacDonald (Central)
- 15 Gail Ott (Louisa)
- 16 Willoughby Parks (Central)
- 17 Heather Pehnec (Central)
- 18 David Plunkett (Central)
- 19 Ginny Reese (Greene)
- 20 Jacqueline Rice (Central)
- 21 Wendy Saz (Crozet)
Bob Bjoring (Central)
- How the Dead Dream by Lydia Millet.
- A Visit from the Goon Squad by Jennifer Egan.
Anne Chiles (Central)
- Molotov's Magic Lantern by Rachel Polonsky.
Nancy Cook (Central)
- Vanished by Sheela Chari.
- Wonderstruck by Brian Selznick.
Meredith Dickens (Gordon)
Krista Farrell (Central)
- Poster: My Life in Twenty-Three Yoga Poses by Claire Dederer.
Noelle Funk (Scottsville)
- The Illumination by Kevin Brockmeier.
Willow Gale (Bookmobile)
- The Wake of Forgiveness by Bruce Machart.
Gary Grant (Albemarle Trustee)
- The Orchard: A Memoir by Adele Crockett Robertson.
John Halliday (Central)
- Angle of Repose by Wallace Stegner.
Holly Huffman (Greene)
- Mandela's Way: Fifteen Lessons on Life, Love, and Courage by Richard Stengel.
Lindsay Ideson (Northside)
- A Discovery of Witches by Deborah Harkness
- This Life is in Your Hands: One Dream, Sixty Acres, and a Family Undone by Melissa Coleman.
Rhonda Johnson (Crozet)
- Vanished by Gary D. Schmidt.
Russ Lyttleton (Central)
- The Greater Journey: Americans in Paris by David McCullough.
Joyce MacDonald (Central)
- Let's Take the Long Way Home: a Memoir of Friendship by Gail Caldwell.
Gail Ott (Louisa)
- The Paris Wife by Paula McLain.
Willoughby Parks (Central)
- Battle Hymn of the Tiger Mother by Amy Chua.
Heather Pehnec (Central)
- The Small Adventure of Popeye and Elvis by Kevin Brockmeier.
David Plunkett (Central)
- The Dream of Perpetual Motion by Dexter Palmer.
Ginny Reese (Greene)
- The False Friend by Myula Goldberg.
- No Such Thing As Dragons by Philip Reeve.
Jacqueline Rice (Central)
- Revolution by Jennifer Donnelly
Wendy Saz (Crozet)
- Emily Alone by Stewart O'Nan.
- Major Pettigrew's Last Stand by Helen Simonson.
- Nothing Daunted: The Unexpected Education of Two Society Girls in the West by Dorothy Wickenden.

subset: commoncrawl


text:
Browsing by Subject "Cellular intelligence"
Now showing items 2-2 of 2
Temporal patterns in artificial reaction networks. (Springer Verlag. http://www.springerlink.com/content/?k=(lncs+7552)+AND+(claire+gerrard), 2012-09)GERRARD, C., MCCALL, J., COGHILL, G. M. and MACLEOD, C., 2012. Temporal patterns in artificial reaction networks. In: A. E. P. VILLA et al (eds.) Artificial Neural Networks and Machine Learning – ICANN 2012: 22nd Annual Conference on Artificial Neural Networks. 11-14 September 2012. Berlin: Springer. Pp. 1-8.The Artificial Reaction Network (ARN) is a bio-inspired connection-ist paradigm based on the emerging field of Cellular Intelligence. It has proper-ties in common with both AI and Systems Biology techniques including ...


text:
Sons of Anarchy Season 4
Buy Now! Add to Wishlist
Ride full-throttle with the Sons of Anarchy into the most intense, adrenaline-charged season ever! Out of prison and back in business, SAMCRO faces a powerful new nemesis as they forge an unlikely alliance and head in a dangerous new direction. As a deadly internal power struggle rocks the club to its very core, Jax struggles with the legacy of his father and makes plans for the future of his family amid chaos, corruption, betrayal, and murder. Action-packed with electrifying extended episodes, Sons of Anarchy Season Four will take you for the ride of your life!
Disc Information
Disc 1:
**Una Venta
**SOA Gear
**Deleted Scenes
**Dorylus - Extended Scenes
**Commentary on Out
Disc 2:
**With an X
**Fruit for the Crows
**Family Recipe
**SOA Gear
**Deleted Scenes
**Brick - Extended Scenes
**Family Recipe - Extended Scenes
Disc 3:
**Call of Duty
**SOA Gear
**Kiss - Extended Scenes
**Commentary on 'Hands' with Peter Weller
**Commentary on 'Hands' with Kurt Sutter, Katey Sagal, Maggie Siff
Disc 4:
**Burnt and Purged Away
**To Be, Act 1
**To Be, Act 2
**SOA Gear
**Deleted Scenes
**Pineys Farewell
**The Fans of Anarchy
**Anarchy at House of Blues
**Commentary on 'To Be - Act 1'
**Commentary on 'To Be - Act 2'


text:
Original URL: https://www.theregister.co.uk/2011/05/02/mozilla_ionmonkey_jit_compiler/
Mozilla answers Google's Crankshaft with IonMonkey
Another simian joins Firefox JavaScript engine
Posted in Software, 2nd May 2011 18:35 GMT
Mozilla is developing a new JIT compiler for SpiderMonkey – the Firefox JavaScript engine – aiming to provide a new set of JavaScript optimizations. Known as IonMonkey, this will be SpiderMonkey's third JIT, but Mozilla hopes to consolidate all its optimization work on the new platform.
The project is led by David Anderson and David Mandelin, who were instrumental in building the JaegerMonkey JIT that was added to Firefox 4. Anderson and Mandelin aim to at least match the speed of Firefox's Trace JIT and Google's Crankshaft JavaScript engine.
When Google first revealed Crankshaft last fall, Mandelin said that Mozilla's JavaScript team and developer community "definitely have the skills and resources to enhance" the Firefox engine in ways that rival Google's design, and he indicated that work would begin soon after the release of Firefox 4.
"Plenty to do after Firefox 4 comes out," Mandelin said . "In the words of David Anderson, 'The game's back on'."
Crankshaft was inspired by Sun's Java HotSpot performance engine, the revamped Java virtual machine that arrived in 1999, according to an exchange between The Register and Google engineer Eric Kay in December. Google Chrome developer Lars Bak was the lead man on the Sun HotSpot team, and Crankshaft uses HotSpot-like "adaptive compilation", identifying important code and optimizing that code as needed.
This is also reminiscent of what Mozilla does with the TraceMonkey extension to its JavaScript engine. But TraceMonkey "traces" code, detecting loops and converting them to assembly code. It works in tandem with JaegerMonkey. When TraceMonkey doesn't apply, JaegerMonkey kicks in and converts entire methods into assembly.
IonMonkey will make use of the Type Interface project from Mozilla man Brian Hackett, an effort to work around JavaScript's untyped setup. "[Hackett's project] is a hybrid static and dynamic analysis that is able to pinpoint, for certain, the types for every variable and property in a JavaScript program. This allows you to remove all sorts of run-time checks and perform optimizations that would otherwise be impossible," Anderson tells Infoq.
Mozilla intends to share all its IonMonkey code across the x86, x64, and ARM platforms. ®


text:
Fishermen in Rhode Island's Narragansett Bay were urged to keep a lookout this weekend for a brown pelican spotted on Prudence Island. Pelicans generally aren't seen north of the Carolinas, but experts say Hurricane Sandy blew many of the birds into the Northeast. Wildlife advocates asked fishermen to try to capture the Prudence Island pelican if they see it and bring it to a wildlife clinic. The Newport Daily News reported that another pelican found in Galilee on Nov. 7 and a third that landed on a fishing boat about 120 miles south of Block Island were expected to be flown to Florida this weekend by the Wildlife Rehabilitators Association of Rhode Island.
Newport, R.I.


text:
hi all
i have a mongoose teocali super 2009.
i had this problem for a long time but only now i want to fix it.
the problem are the loosening of the rear suspension bearings and the creaks and squeaks i hear from it (especially when i pedal hard).
i have put a lock-tight on all bearings.
one of the bearings keeps opening and my questions are:
1. does the creaks is the result of the bearing not being lock tightly enough? should i open them and put a new lock-tight and then close them really tight.
2. how tight should i close the bearings?
3. do i need to grease the bearings? how it should be done?
10x in advance
waiting for your help


text:
Welcome to DoubleCommand!
27th October 2013 - Thanks to the efforts of Adam Strzelecki DoubleCommand 1.7 is released, adding support for Mac OS X 10.9 (Mavericks), and dropping support for 10.4 and 10.5.
29th June 2011 - It has been a long time since anything has changed here, and so I'd just like to make you aware that if DoubleCommand does not fully support a new keyboard you use (like in a new Macbook perhaps), or if it doesn't support a feature you need, you might find some help at pqrs.org/macosx/keyremap4macbook.
24th November 2009 - DoubleCommand 1.6.9 released, fully supporting 64-bit for the prefpane and the kext (for those who want to use the 64-bit kernel). This is a universal binary, so only one kext and prefpane is needed for any Mac OS X 10.4 and up computer.
2nd September 2009 - Snow Leopard (Mac OS X 10.6) has been released, but I might not be able to have a copy running for a couple of weeks. However, most reports coming in are that the existing DoubleCommand works fine on 10.6 in 32 bit kernel mode, and if you're using DoubleCommand, chances are that 32 bit is not only the default, but is just fine for you right now. I have been sent a patch by Ryan Walklin (thanks!) that should support the 64 bit kernel, but I won't be able to release that until I can test that it works, which should be a couple of weeks at most.
10th March 2009 - DoubleCommand 1.6.8 just adds back the missing options from the preference pane.
5th February 2009 - Release DoubleCommand 1.6.7 is out, this fixes problems with the control key not working in certain situations, and adds an uninstaller script for when things go wrong.
9th May 2008 - New beta DoubleCommand 1.6.6b4 is out, this rolls back the control key fix from the last beta, which seemed to break some features, and adds a number of new features contributed by Sastira - Using the right Option key as forward delete, Control or Enter, swapping delete and forward delete, and using caps lock as forward delete.
25th March 2008 - New beta DoubleCommand 1.6.6b3 is out, this seems to fix kernel panics for some on Mac OS X 10.5, and should also solve a problem with the Control key becoming stuck. Please report whether it works for you or not, and what version of Mac OS you have, and the keyboards and type of computer you're using it on.
22nd February 2008 - I've just had a report that Mac OS X 10.5.2 seems to stop kernel panics when using DoubleCommand, so please post in the forum and let us all know your experience with this. I've also been told that there is a new Built-In Keyboard Firmware Update - please disable DoubleCommand before applying this update, you can safely add DoubleCommand back afterwards.
6th November 2007 - DoubleCommand 1.6.6b1 is available for testing, several reports of success on Mac OS X 10.5 have given me enough reason to post this here, however I have not yet tested this myself with the new OS. Please let me know how it works for you if you try it!
30th October 2007 - Mac OS X 10.5, Leopard, has been released, and I expect to have a copy at some point. Until then, reports have been mixed: some have had success running the current version of DoubleCommand as is, some seem to have required uninstalling then reinstalling, and some have experienced occasional kernel panics, only possibly related to DoubleCommand. My advice is to disable DoubleCommand before upgrading to avoid upgrade problems, then enable when you've got everything else sorted out.
6th August 2007 - Release 1.6.5 removes the unnecessary log output.
25th July 2007 - Release 1.6.4 adds Caps lock to delete feature for the Colemak keyboard layout. Also added internals for multiple keyboard support.
26th June 2007 - Updated website layout. The highest priority now is having settings per keyboard, or at least only applying DoubleCommand to a single keyboard. Also released DoubleCommand 1.6.3, a minor update which allows using backslash as delete with Option to delete to word boundaries.News Archive


text:
EAST RUTHERFORD, N.J., Feb. 10 /PRNewswire-FirstCall/ -- Cambrex Corporation (NYSE: CBM) reports fourth quarter results for the period ended December 31, 2009.
Fourth Quarter 2009 Operating Results
Fourth quarter 2009 sales of $58.7 million were 9.9% lower than the fourth quarter 2008. Excluding a 5.9% favorable impact of foreign exchange, reflecting a weaker U.S. dollar, sales decreased 15.8%. The decrease is primarily due to lower volumes of an active pharmaceutical ingredient ("API") that utilizes the Company's polymeric drug delivery technology, lower sales of two APIs manufactured under long-term supply agreements and lower custom development revenues, all due to the timing of orders throughout 2009. Volumes of a feed additive for which a contract expired earlier in 2009 were also lower. Partially offsetting these decreases were increased generic revenues resulting from improved order patterns.
Fourth quarter 2009 Gross Margin increased to 24.7% of sales from 24.2% during the fourth quarter 2008, with foreign currency unfavorably impacting gross margin by 0.6% in the fourth quarter 2009. Cost reductions, and to a lesser extent, positive product mix, were the main drivers of the higher margins. This was partially offset by lower pricing of generic APIs and lower volumes of an API manufactured under a long-term supply agreement.
Selling, General and Administrative Expenses in the fourth quarter 2009 were $8.8 million compared to $9.0 million in the same period last year. The decrease is a result of lower personnel costs and professional fees at the corporate headquarters and the benefit of the termination of certain postretirement benefits partially offset by higher legal fees, higher expenses at the Company's manufacturing sites and an unfavorable impact of foreign currency.
Research and Development Expenses increased to $2.0 million in the fourth quarter 2009 from $1.6 million in the fourth quarter 2008 due to higher costs related to the development of new products and technologies.
Operating Profit increased to $3.7 million in the fourth quarter 2009 from $1.8 million in the fourth quarter 2008. Excluding Restructuring Expenses and Strategic Alternative Costs of $3.3 million recorded in 2008, Operating Profit decreased $1.4 million quarter over quarter. EBITDA was $9.4 million, or 16.0% of sales, compared to Adjusted EBITDA of $10.5 million, or 16.0% of sales last year.
The Provision for Income Taxes totaled $5.7 million in the fourth quarter 2009 compared to $1.1 million in the fourth quarter 2008. Provision for Income Taxes includes a $5.3 million expense in the fourth quarter 2009 related to an ongoing audit of a European subsidiary. The Company's effective tax rates have been and are expected to remain highly sensitive to the geographic mix of income due to the Company's inability to recognize tax benefits where there has been a recent history of losses, primarily in the U.S.
Net Loss for the fourth quarter 2009 was $2.8 million or $0.09 per share compared to $1.0 million or $0.03 per share in the fourth quarter 2008.
Capital expenditures and depreciation for the fourth quarter 2009 were $2.9 million and $5.7 million compared to $7.3 million and $4.9 million in the fourth quarter 2008, respectively. The decrease in capital expenditures is largely due to fourth quarter 2008 spending on two large capital projects for which the majority of work has since been completed.
Steven M. Klosk, President and Chief Executive Officer, said, "We are pleased to finish 2009 at the high end of our prior earnings guidance, with just over $47 million in EBITDA. We successfully managed working capital and expense levels throughout the business and reduced net debt by nearly $23 million during the year.
"As we entered 2009 the macro-economy suggested a conservative approach that led us to focus on reducing costs and maximizing cash flow. While the outlook for the economy appears to have stabilized as we start 2010, our smaller customers continue to face a difficult funding environment and pricing pressures continue to exist in most product categories. The 2010 forecasts for certain of our larger products are lower than we expected, and in some cases lower than 2009, for a variety of reasons. We renegotiated an extension of an important contract for certain drug delivery products during the fourth quarter, and made price and volume concessions in order to maintain the majority of the share of this business over the next three years. These are key factors contributing to our guidance of flat to lower sales and profits for 2010.
"We have opportunities to grow revenues through the advancement of projects in our pipeline of late stage development products, within our controlled substances and drug delivery categories and through the launch of new generic APIs. However, we are convinced that we need to invest more aggressively, both internally and externally, in niche markets, novel technologies, and new geographies that generate sustainable growth. Of course, we will continue to identify ways to further reduce costs and increase cash flow as we focus on growing the business."
The Company currently expects that sales for 2010, excluding the impact of foreign currency, will be between a decline of 5% and an increase of 1% versus 2009. Full year 2010 EBITDA is currently expected to be between $41 and $47 million.
For 2010, capital expenditures are expected to be approximately $12 to $15 million and depreciation is expected to be $22 to $24 million.
The financial information contained in this press release is unaudited, subject to revision and should not be considered final until the 2009 Form 10-K is filed with the SEC.
Basis of Reporting
The Company has provided a reconciliation from adjusted and other non-GAAP amounts to GAAP amounts at the end of this press release. Management believes that this basis of reporting provides a more meaningful representation of the Company's historical operating results for the periods presented due to the magnitude and nature of certain recorded expenses in prior years.
Conference Call and Webcast
The Conference Call to discuss fourth quarter 2009 results will begin at 8:30 a.m. Eastern Time on Thursday, February 11, 2010 and last approximately 45 minutes. Those wishing to participate should call 1-888-634-4003 for domestic and +1-706-634-6653 for international. Please use the pass code 54652678 and call approximately 10 minutes prior to start time. A webcast is available from the Investors section on the Cambrex website located at www.cambrex.com and can be accessed for 30 days following the conference call. A telephone replay of the conference call will be available through Thursday, February 18, 2010 by calling 1-800-642-1687 for domestic and +1-706-645-9291 for international. Please use the pass code 54652678 to access the replay.
Forward Looking Statements
This document may contain "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 and Rule 3b-6 under The Securities Exchange Act of 1934, as amended, including, without limitation, statements regarding expected performance, especially expectations with respect to sales, research and development expenditures, earnings per share, capital expenditures, acquisitions, divestitures, collaborations, or other expansion opportunities. These statements may be identified by the fact that they use words such as "expects," "anticipates," "intends," "estimates," "believes" or similar expressions in connection with any discussion of future financial and operating performance. Any forward-looking statements are qualified in their entirety by reference to the factors discussed throughout the Company's public filings. Any forward-looking statements contained herein are based on current plans and expectations and involve risks and uncertainties that could cause actual outcomes and results to differ materially from current expectations including, but not limited to, global economic trends, pharmaceutical outsourcing trends, competitive pricing or product developments, government legislation and regulations (particularly environmental issues), tax rate, interest rate, technology, manufacturing and legal issues, including the outcome of outstanding litigation disclosed in the Company's public filings, the Company's ability to satisfy the continued listing standards of the New York Stock Exchange, changes in foreign exchange rates, uncollectible receivables, loss on disposition of assets, cancellation or delays in renewal of contracts, lack of suitable raw materials or packaging materials, the Company's ability to receive regulatory approvals for its products and other factors described under the caption "Risk Factors That May Affect Future Results" in the Company's Quarterly Report on Form 10-Q for the period ending September 30, 2009. Any forward-looking statement speaks only as of the date on which it is made, and the Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. New factors emerge from time to time and it is not possible for the Company to predict which will arise. In addition, the Company cannot assess the impact of each factor on its business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements.
For further details and a discussion of these and other risks and uncertainties, investors are cautioned to review the Cambrex 2008 Annual Report on Form 10-K, including the Forward-Looking Statement section therein, and other filings with the U.S. Securities and Exchange Commission. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise.
About Cambrex
Cambrex provides products and services to accelerate the development and commercialization of small molecule therapeutics including APIs, advanced intermediates, enhanced drug delivery, and other products for branded and generic pharmaceuticals. The Company currently employs approximately 850 people worldwide. For more information, please visit www.cambrex.com.
CAMBREX CORPORATION Statement of Profit and Loss For the Quarters Ended December 31, 2009 and 2008 (in thousands) 2009 2008 ------------- ------------- % of % of Amount Sales Amount Sales ------ ----- ------ ----- Gross Sales $58,709 100.0% $65,178 100.0% Allowances and Rebates 779 1.3% 962 1.5% ------ ------ Net Sales 57,930 98.7% 64,216 98.5% Other Revenues (63) -0.1% (83) -0.1% ------ ------ Net Revenues 57,867 98.6% 64,133 98.4% Cost of Goods Sold 43,353 73.9% 48,365 74.2% ------ ------ Gross Profit 14,514 24.7% 15,768 24.2% Operating Expenses Selling, General and Administrative Expenses 8,822 15.0% 9,010 13.9% Research and Development Expenses 2,005 3.4% 1,645 2.5% Restructuring Expenses - 0.0% 3,226 4.9% Strategic Alternative Costs - 0.0% 107 0.2% ------ ------ Total Operating Expenses 10,827 18.4% 13,988 21.5% ------ ------ Operating Profit 3,687 6.3% 1,780 2.7% Other Expenses/(Income): Interest Expense, net 1,224 2.1% 1,366 2.1% Other (Income)/Expense, net (502) -0.9% 295 0.5% ------ ------ Income Before Income Taxes 2,965 5.1% 119 0.1% Provision for Income Taxes 5,733 9.8% 1,069 1.6% ------ ------ Net Loss $(2,768) -4.7% $(950) -1.5% ====== ====== Loss per Share of Common Stock Basic $(0.09) $(0.03) Diluted $(0.09) $(0.03) Weighted Average Shares Outstanding Basic 29,286 29,175 Diluted 29,286 29,175 CAMBREX CORPORATION Statement of Profit and Loss For the Twelve Months Ended December 31, 2009 and 2008 (in thousands) 2009 2008 --------------- -------------- % of % of Amount Sales Amount Sales -------- ----- ------- ----- Gross Sales $236,277 100.0% $249,618 100.0% Allowances and Rebates 1,402 0.6% 2,099 0.8% ------- ------- Net Sales 234,875 99.4% 247,519 99.2% Other Revenues (325) -0.1% 1,709 0.6% ------- ------- Net Revenues 234,550 99.3% 249,228 99.8% Cost of Goods Sold 164,272 69.6% 175,485 70.3% ------- ------- Gross Profit 70,278 29.7% 73,743 29.5% Operating Expenses Selling, General and Administrative Expenses 35,711 15.0% 40,521 16.2% Research and Development Expenses 7,929 3.4% 7,590 3.0% Restructuring Expenses - 0.0% 4,695 1.9% Strategic Alternative Costs - 0.0% 1,515 0.6% ------- ------- Total Operating Expenses 43,640 18.4% 54,321 21.7% ------- ------- Operating Profit 26,638 11.3% 19,422 7.8% Other Expenses/(Income): Interest Expense, net 4,634 2.0% 3,668 1.5% Other (Income)/Expense, net (641) -0.3% 754 0.3% ------- ------- Income Before Income Taxes 22,645 9.6% 15,000 6.0% Provision for Income Taxes 12,253 5.2% 7,071 2.8% ------- ------- Net Income $10,392 4.4% $7,929 3.2% ======= ======= Earnings per Share of Common Stock Basic $0.36 $0.27 Diluted $0.36 $0.27 Weighted Average Shares Outstanding Basic 29,241 29,116 Diluted 29,267 29,161 CAMBREX CORPORATION Reconciliation of GAAP to non-GAAP Results For the Quarters and Twelve Months Ended December 31, 2009 and 2008 (in thousands) Fourth Quarter Fourth Quarter 2009 2008 -------------- -------------- Operating Profit, as Reported $3,687 $1,780 Depreciation and Amortization 5,731 4,940 Strat. Alt. & Restructuring Expenses* - 3,333 CEO Retirement** - 408 -------------- -------------- Adjusted EBITDA $9,418 $10,461 ============== ============== Twelve Months Twelve Months 2009 2008 -------------- -------------- Operating Profit, as Reported $26,638 $19,422 Depreciation and Amortization 20,505 21,055 Strat. Alt. & Restructuring Expenses* - 6,210 CEO Retirement** - 1,040 -------------- -------------- Adjusted EBITDA $47,143 $47,727 ============== ============== * During 2008, the Company incurred expenses related to restructuring activities and strategic alternative expenses pursuant to the sale of its Bioproducts and Biopharma businesses in February 2007 and for the consolidation of the New Jersey R&D facility. These costs are identified within the 2008 income statement and have been excluded from the calculation of certain profit measurements, including Adjusted EBITDA for 2008. ** During 2008, the Company incurred expenses related to the retirement of its former CEO. These costs are included within Selling, General and Administrative Expenses and have been excluded from the calculation of certain profit measurements, including Adjusted EBITDA for 2008. CAMBREX CORPORATION Consolidated Balance Sheet As of December 31, 2009 and 2008 (in thousands) December 31, December 31, Assets 2009 2008 ------ ----------- ----------- Cash and Cash Equivalents $52,365 $32,540 Trade Receivables, net 32,025 36,685 Inventories, net 58,369 61,133 Prepaid Expenses and Other Current Assets 6,654 8,798 ----------- ----------- Total Current Assets 149,413 139,156 Property, Plant and Equipment, net 161,149 161,500 Goodwill 36,360 35,374 Other Non-Current Assets 4,593 5,042 ----------- ----------- Total Assets $351,515 $341,072 =========== =========== Liabilities and Stockholders' Equity ------------------------------------ Accounts Payable $17,038 $19,700 Accrued Expenses and Other Current Liabilities 38,013 45,080 ----------- ----------- Total Current Liabilities 55,051 64,780 Long-term Debt 120,800 123,800 Deferred Tax Liabilities 17,305 16,138 Accrued Pension and Postretirement Benefits 40,963 44,165 Other Non-Current Liabilities 14,126 17,403 ----------- ----------- Total Liabilities $248,245 $266,286 Stockholders' Equity $103,270 $74,786 ----------- ----------- Total Liabilities and Stockholders' Equity $351,515 $341,072 =========== ===========
SOURCE Cambrex Corporation
|SOURCE Cambrex Corporation
Copyright©2010 PR Newswire.
All rights reserved


text:
Former chemistry department head Dixon dies at 93
Joseph Dixon, professor emeritus of chemistry and former head of the Penn State Department of Chemistry, died Feb. 7 at the age of 93.
Born in Philadelphia on Nov. 4, 1919, Dixon began his career in chemistry in 1937 as an undergraduate student at Penn State, receiving his bachelor's and master's degrees before earning his doctorate in chemistry in 1946. He then became a chemistry instructor at Penn State. From 1951 to 1955, he was a chemist with the California Research Corp. and an associate professor of chemistry at Lafayette College. He then returned to Penn State as a member of the chemistry faculty in 1955, attaining the rank of professor in 1961. His research interests included the study of compounds of organolithium and organomagnesium, the structure of molecules and the physical properties of organic systems.


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|2004-06-22, 10:54
|Link #1
Join Date: Mar 2004
Who wants to bet Kabuto is Itachi?
Frankily I hope this isn't the case....however there is SO much evidence and it is very possible that Kabuto is Itachi in disguise. I doubt I can remember all the things I came up with but I will do my best.
1) Take a look at Itachi and Kabuto's hair, no they arent "exactly" the same but very similar with the hair split down the middle and the ponytail in the back. No other characters in Naruto have this.
2) It was stated that Kabuto arrived in Konoha 6 years ago as an outside survivor if the Amato War (I think this is the right name). This is mentioned in the episode where Kabuto quits from the 2nd test in the Chuunin exam. I find it pretty interesting that it was 7 years ago that Itachi destroyed the Uchiha clan and left Konoha. Coincidentally this kid "Kabuto" shows up in Konoha a year after Itachi left and somehow managed to survive a huge war. Only someone with very impressive ninja skills could do this.
3) In anime episode 88 at the very beginning right after Orochimaru kills his servant and Kabuto walks in, Kabuto states (this is not word for word but very close)...."I was away for a while and I already need to clean up this mess". Yes he indeed was away, just so you remember this takes place right after Itachi and Kisame run away from Jiraya's ninjustu.
4) Itachi and Kabuto share very similar characteristics. Neither of them get mad or lose their cool. The are both extremely intelligent and can get to people's heads by just talking. Both are very powerful (everyone assumes Kabuto is hiding something because he is a mysterious character) yet tend to avoid fighting if possible.
5) Both are data gatherer's. Itachi seems to know a lot about Naruto, he even states after he runs from Jiraya that "we don't need to worry about Naruto in his current state". Pretty funny he knows all this considering Kabuto has been observing Naruto the entire time. In episode 88 Kabuto claims to have knowledge about Tsunade from the Amato War. Interesting how he was collecting information even back then like he was on a mission or something...*hint hint* Read the spoiler below.
6) Kabuto isn't intimidated by Orochimaru in the least. A lot of people are waiting for Orochimaru to get killed and many people think that Kabuto has some hidden motive. In fact I find it funny in the episode where Sasuke gets owned by Itachi, Itachi notices the seal (doesn't say anything but it shows him looking at it) when Sasuke is on the ground. Then in the next episode he is telling Sasuke he is weak because he doesn't have enough hate, basically implying he MUST go to orochimaru. Something weird is definately going on here.
There are probably a few more things I could put on here but I think it is enough. For those of you who have read the manga and are trying to give me a counter example read below.
Let me know what you guys think. Thanks!
|2004-06-22, 11:01
|Link #5
Join Date: Dec 2003
While I dont agree with you, its an interesting theory. The upcoming events seem to kill your theory in my opinion.
If you want another point, you can use Kabuto's glowing eyes or whatever from the chuunin exam when they are in teh forest of death or whatever. He was probably mad and the sharingan was coming through until he quickly realizes and regains composure.
|2004-06-22, 12:05
|Link #9
Join Date: Dec 2003
Basically no it's not Kabuto because, Kabuto was adopted as a baby by the captain of the med team. He's been around taking and failing the chuhnin exam for 7 years now.
PLEASE USE THE EDIT BUTTON! Christ.
Edit: Also ... how is this an interesting theory when it revolves around incorrect facts ...
|2004-06-22, 12:12
|Link #11
Yummy kakashi thighs...
If Kabuto was Itachi in disguise, I don't think Oro is that STUPID to fall for his trick. Kabuto even said that
So no, I don't think it's Itachi at all. Itachi is too COOL to "pretend" to follow someone around like a bitch. we all know that Kabuto is Oro's bitch!
|2004-06-22, 13:06
|Link #15
uukog proved you wrong
|2004-06-22, 13:37
|Link #20
Senior Member
hey .. u guys dont have to bash him like that ... his theory was good and was pretty well thought out, i dont think its true, but he did a good job at details with it instead of juss makin a thread and saying i think itachi is kabuto, like that gaara is the 4th thread
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Trans Latinas Seek City Funds
As transgender Latinas increasingly speak out about the discrimination and harassment they experience in San Francisco's Mission district, a nonprofit is asking city officials to fund its work to prevent such violence.
El/La Para Translatinas emerged in 2006 after Proyecto ContraSIDA Por Vida, where it had been a program, lost its funding. It is mainly volunteer-led but has been able to tap into HIV funds in order to hire three part-time staffers.
In 2012 El/La estimates it saw 300 trans Latinas utilize its services.
"What we have at El/La is a lot of expertise and a lot of trust with trans Latinas. We created a space for trans Latinas and actually built community," said Marcia Ochoa, El/La's unpaid program director.
Ochoa, who lives in Santa Cruz and teaches at the UC campus there, helped start El/La and travels to the city several times a week for the agency. Her academic work focuses on structural violence that trans women experience in Latin America and helped shape the agency's approach.
"It is about the emergence of the trans movement and political consciousness now," said Ochoa, 42, who is gender variant and identifies as a butch lesbian.
As the discourse around the needs of the transgender community has matured, said Ochoa, there has been greater awareness that trans people are oftentimes excluded in efforts to fight poverty or violence.
"It used to be when people thought about these bread and butter issues that queer and trans people were not seen as 'part of' but seen as 'additional' to it," she said.
Or policies meant to help ended up working against trans people. Ochoa pointed to homeless shelters as one example where certain rules can prevent trans people from accessing such housing.
"We are moving into a new period where finally we are having some recognition of not only trans women in particular but transgender people in general," said Ochoa.
For years the city's Department of Public Health has prioritized transgender women as being in need of HIV prevention services. As part of a collaborative of local agencies serving this population, El/La has received $90,000 a year that pays for an office coordinator, a health education coordinator, and an outreach coordinator who all work part-time.
El/La is now seeking an additional $80,000 from the city in order to hire a full-time case manager and expand the work it is doing around the domestic violence that trans Latinas experience.
"It would really supplement and complement what we are able to do," said Ochoa.
Violence against trans Latinas "is not a recent thing," pointed out Isa Noyola, 34, a transgender woman who has been with El/La for six years and serves as its volunteer office manager.
"Every year we are having to advocate for our community," she said. "We are dealing with the trauma that walks through our door when we are open for drop-in hours."
She added that El/La is "running at a very high level with very little. To me that is not sustainable."
In March El/La took part in a rally held to focus attention on several violent episodes involving trans women in the Mission. That led to the agency working with the office of gay District 9 Supervisor David Campos, who represents the Mission, on ways to bolster its funding.
Campos has become a vocal backer of El/La and helped raise $5,000 for the agency during a fundraiser last weekend that also netted enough money to save Mission gay bar Esta Noche.
He invited several El/La staffers and clients, including Noyola, to speak at a recent budget hearing Campos co-hosted with Mayor Ed Lee and gay District 8 Supervisor Scott Wiener. And he again pointed to the need for additional city resources for trans Latinas during a hearing he held last week at City Hall about the violence directed toward trans women.
"We need to set up a meeting with the key players to come up with a comprehensive strategy around the budget in terms of what additional resources are needed," Campos said during the May 16 hearing before the supervisors' Neighborhood Services and Safety Committee, which he chairs. "We need to create domestic violence funding for the trans community."
El/La has also courted support this year from the San Francisco Domestic Violence Consortium, a collaborative between 17 agencies that advocates around the issue and lobbies for funding.
"We are certainly on their side and want them to be successful," said Beverly Upton, the consortium's executive director.
The agency has begun conversations with the San Francisco Commission on the Status of Women about its funding process. While it has awarded grants to several nonprofits that serve transgender women, the commission has never directly funded an agency whose sole focus is on transgender clients.
Emily M. Murase, Ph.D., executive director of the city's Commission on the Status of Women, attended and spoke at the board hearing. In a later interview with the Bay Area Reporter, she said that she recognizes there is an urgent need to address the issues brought up both in public and during a private meeting she had with El/La.
"Really, the extent of the harm of the violence against this particular demographic has become painfully clear to this department recently. So in the light of that, clearly there is unmet need here and we would like to do what we can," said Murase. "We are looking to see what options are available for how can we improve San Francisco's response."
The commission operates on a three-year funding cycle. For fiscal years 2011-2012 through 2013-2014 it selected 25 different agencies, two of which are LGBT-focused, to share in $3.2 million earmarked for violence against women programs. It did not receive any requests for funding from a trans-specific program.
The commission is currently working on its next requests for funding, which would begin July 1, 2014. It is expected the lack of trans women programs will be highlighted in its next community needs assessment to be released sometime later this year.
It is possible that some funding for a trans program could be allocated off-cycle this year. If that were the case, El/La would have a chance to apply.
Ochoa expressed optimism about El/La receiving funding from the city for additional staff going forward.
"We are always cautiously optimistic," she said. "We could put them in place right away and make a huge difference in the lives of the people we work with day to day."
Until now the trans Latina program has not actively fought for additional funds, mainly due to being short staffed.
Noyola works full-time overseeing the workforce program for paid internships for LGBT youth at LYRIC, the Lavender Youth Recreation and Information Center. The agency serves as El/La's fiscal sponsor and does receive funding from the Commission on the Status of Women for its Queer Young Women's Health and Safety Project.
"For us, I think, we have kept insular for many reasons. We are definitely focused on the priorities of our women," Noyola told the B.A.R. "Our capacity to be part of so many different conversations in the city has been limited. To me, it is about kind of looking at reprioritizing where we are getting support."
Nor was El/La aware there is a vacant seat currently on the Commission on the Status of Women until asked about it by the B.A.R. The seat has been open since October.
The mayor appoints all seven commissioners who serve four-year terms. Currently, there is one lesbian member, political consultant Andrea Shorter.
There has not been a transgender appointee since March 2009, when Nikki Calma, also known by her drag name Tita Aida, resigned. Her appointment in 2008 marked the first time a trans woman had served on the commission.
It is unclear why Lee has yet to fill the seat, or if he is considering naming a trans woman. His spokespeople did not respond to the B.A.R. 's request for comment, while staffers at the commission were unaware of a trans woman applying for the vacancy.
While Noyola and Ochoa both stated they believe it is important for a trans woman to serve on the commission, neither was sure they would have the time to do so themselves as they are already juggling their duties at their paid jobs with their volunteer work.
Part of their mission is to build the leadership skills of the women El/La serves so they can be public advocates. That can be difficult, though, when many of the trans women they see do not speak English.
"We are starting from the ground up. It has been challenging finding resources for our community that is linguistically appropriate," said Noyola. "The fact our women are coming out to speak publicly is due to our work. There needs to be representation, whether myself or someone else, who can speak for the trans Latina community, the immigrant community, and the monolingual community."
El/La is located at 2940 16th Street, Suite 319, at Capp. It is open Tuesday to Friday from 5 to 9 p.m.
For more information, visit http://www.ellaparatranslatinas.org/about-us.php.


text:
If you have any doubt about the color of your 1990 Audi A8, please note:
The paint code is normally located in the back compartment panel in the trunk. Click here for an Audi paint code location diagram and label example.
Call 1-888-710-5192.
We probably have it.
I purchased my touch up kit from you a few weeks ago and tested the color on the inside of the trunk and it looks perfect to me. Now I am tossed between doing all the touch ups myself, which I am not too sure I can handle or take it to a full body shop to make sure it gets done right, and only because I am not a painter or body man.
Thanks for the good service.
Share your touch up story...
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I love my 'puter and my 'puter loves me
The "Terminator" movie franchise starring the currently unpopular Ahnold appears to have been more prophetic than the creators intended. The computers are indeed taking over, but not by way of a violent revolution.
They are passively winning our hearts. The need for human companionship on an emotional and intellectual level is fading into obsolescence. The advent of the android could make that concept a reality.
Although a functioning android is still an imagining of science fiction, so was today's high tech personal computer less than 50 years ago.
Think about it. Your personal computer is like having an erudite friend who is never in a bad mood, offensive, or too busy to spend time with you. Whenever you feel like asking a question, as long as you're specific, you'll get the answer you're seeking. It will never make you feel stupid, and it never has to get back to you. Instant gratification is at your fingertips.
When you are on the road and manage to get lost, your GPS is a touch screen away. On your cell phone or on your dashboard, in just a few seconds a GPS unit can tell you where you are and how to get where you want to go. It can, and usually does, employ a pleasant voice to give you directions. It is another product of computer magic.
If you want to play games, do research on any subject, go shopping, or even get a date with another human, your computer will do your bidding. Unlike a human companion, whenever you tire of your computer's company, you can just turn it off and it will never complain.
Furthermore, it doesn't care if you're a totally out-of-shape couch potato. If you want to do something to improve your physicality, you can get assistance from programs designed to help you do everything from losing weight to reshaping your body – all through your computer. What's not to like?
The many social networks like Facebook, Twitter and LinkedIn offer computer users the opportunity to network with others of the same mindset. You can be an active member of the virtual community in the safe confines of your home where you can communicate with people from all over the globe without the risk of face-to-face exposure.
However, if you want to meet someone face to face without actual physical confrontation, you can do that too, by using a webcam. Most computers come with one built in.
You can see and hear the person you're communicating with and they can see you. The difference is, when the conversation takes an uncomfortable turn, or if you don't like what you see, a click of a mouse makes the other person go away. A few more clicks, and that person can be blocked from sending you an IM, e-mail, or from communicating with your computer in any way. Cool, huh?
Well, maybe not. The downside of the virtual world has been evident for some time. It began with business. Shopping centers and malls are all but disappearing.
More people are shopping on the Internet where they can sit at home in their pajamas and compare prices in the middle of the night. Then they can make their purchases and have everything from their groceries to Christmas presents delivered to their doorsteps. Other than the groceries, they can have nearly everything else delivered to any doorstep on the planet.
I admit I am guilty. For the past few years, I have not stepped into a single store to do my Christmas shopping or to buy gifts of any kind. I have purchased concert tickets, books, toys, movies and household furnishings via the Internet. Lines, clerks in foul moods, out-of-stock items, bad weather and parking hassles have all been eliminated.
On the social side of the situation, young people no longer go on dates. They hook up when they need any degree of physical contact. If they want to talk, they text each other, converse on cell phones, or send IMs and emails. Long-distance marriages are becoming common. Married couples live and work in different cities, and get together on weekends for physical relations.
When the androids become a reality, our tribal social system will change dramatically. If the computers have their way, we could be totally dependent on technology if we want to exist in a system we can't understand.


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By Liam Twomey
When he arrived at Stamford Bridge from Wigan back in August, few expected Victor Moses to emerge from this season as a Chelsea success story. After a summer in which Roman Abramovich splashed out over £70 million on creative talent, a campaign spent mainly becoming acquainted with tracksuits and benches seemed the likelier outcome.
Yet, seven months and 38 appearances in all competitions later, the 22-year-old has established himself as a significant and consistent contributor to the Chelsea revolution, even as it has stuttered and lost its way. "I wasn't expecting to play so much but, if you look at the amount of games we've played this season, you would expect everyone to get a chance," Moses, speaking on behalf of Western Union's PASS initiative, tells Goal.com.
"But I do really appreciate the amount of games I've played, because the more you play, the more experience you get. I've played in the Champions League and the Europa League, so I'm really enjoying myself at Chelsea at the moment."
Chelsea's struggles on the pitch and seemingly insatiable appetite for chaos off it, however, have soured such personal achievements. The Europa League is the only one of eight trophies the club in which has competed for this term that remains a live target, while qualification for next season's Champions League is less assured than anyone could have expected.
"I can't say it's been a great season for us," Moses admits, "but it's not over yet. We just need to get ourselves together. We've got the Europa League semi-final [against Basel] coming up on Thursday and that's a massive game.
"But it's not just that. Every game we've got now is very important if we're going to finish in the top four and play in the Champions League next season. This season has been a bit of a disappointment, but I can still see us picking up a trophy."
Regardless of whether Chelsea end up claiming a second European trophy in as many years at Ajax's Amsterdam Arena in May, the enduring memory of the season for many Blues fans will be the brutal sacking of club legend Roberto Di Matteo in November.
The Italian's replacement, Rafa Benitez, is arguably the most loathed manager in the club's history and the Spaniard's continuing presence in the dugout has often led to a poisonous atmosphere at Stamford Bridge. He won just two of his first seven home games and has 11 wins from 17 overall.
But Moses insists that the vitriol has not hindered him or his team-mates. "I haven't seen it affecting the team," he insists. "We've just stayed focused on the games we're playing and tried to get three points every time, regardless of what's going on with the fans, because we want to be in the top four this season.
"Roberto and Rafa are both good managers. They've both won the Champions League and are very experienced, so I've enjoyed my time working with them. Rafa's doing well at the moment and Roberto won two trophies last season, so they're both very good."
|Chelsea are 5/4 favourites with William Hill to win the Europa League
"I think the squad rotation has been important for us with the number of games," he adds. "It's good to have that around the team. We've played a lot of games, especially with the Europa League, which is why everyone has needed to play. It's taken a lot out of us but we've managed it very well. We've had a couple of players out injured but they're back now and we're delighted with that."
One of the players to have shone in spite of Benitez's tinkering is Frank Lampard. The 34-year-old has scored 12 Premier League goals despite completing a full 90 minutes on just 13 occasions, as he edges ever closer to Bobby Tambling's all-time Chelsea scoring record of 202.
Lampard's future past the end of his contract in the summer is in doubt but Moses and his team-mates have no desire to say goodbye at the end of the campaign. "Everyone would love to see Frank stay next season," he insists. "He's been magnificent for us this year, scoring goals and creating goals as well, and he's a legend for the club."
For now, though, the focus at Stamford Bridge is very much on winning the top-four race and earning a shot at Champions League redemption next term.
"Every game is important but, having been knocked out like we were this year, we definitely want to be playing Champions League football next season," Moses continues. "It's a massive tournament for us, having won it last year, so to be playing in it again next season would be great."
Follow Liam Twomey on


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Here we go.
The two long range guys fire at the walker pilot.
and hit!
They then follow the rest of their team
The other troops head into the river, and one grabs the rocket launcher(2 shots left)
The hero grabs a guy...
And lobs him through the window
Then the rocket guy kills an undead.
The last diver long range guy fires out the window
He headshots! (must have been the wicked mustache)
The diver's last pistol guy, heads out the door...
... and dies
The last living deserter (in an actual solid form) heads inside the weapon stash
And kills the mad-evil
He then sets up a defensive position with the repeating cannon
Meanwhile, gore-ball absorbs more of his (its?) pieces
Three pirates move up and fire at the speeder. They failed
The clones walk
The speeder fires its last rocket
I think this picture explains what happened
The droids move up.
They kill the shield-wench.
The skeleton temporarily corrupts the zombies' weapons, allowing them to convert people this turn
The pistol zombie attacks a mad-evil, and fails
The other zombie heads into the building, and misses his target too.


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Terrible touch detection
This is a potentially great game that is greatly diminished by its wonky touch detection system (on iPad 3 and iPad Mini). You will find that on many occasions you'll need to make multiple swiping motions before the quarterback throws the ball. Previous games produced by this developer didn't have this touch detection problem, so hopefully they'll be able to rectify it soon.
Last edited by Grist; 01-25-2013 at 11:08 PM.


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Why isn't he on anxiety medication? If he is I've never read anything about him taking any.
Why isn't he on anxiety medication? If he is I've never read anything about him taking any.
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Even though Royce White is missing, he can't be too far because he is scared to fly.
We get it, it's an issue, but he's handling this the wrong way. He's only doing himself a disservice by tweeting about it every 2 seconds and blaming everyone for not being sensitive to his needs. Despite what he says, I think the Rockets have handled this well even though I think it was a mistake drafting him so high. I saw this ordeal coming together on draft night.
too bad. Looks like the rockets lost a draft pick. Sucks because he is a skilled guy but hopefully he gets it together
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I hope they are able to cut him on legal grounds and not pay him due him breaking legal grounds on his contract. how much effort is one #18 draft pick worth? At this point I don't care about how great he COULD be. I would throw stones at him if I saw him at the Rocket center. A young team like this has no need for one guy causing so many issues.
survival of the fittest, he is done....
C: Asik PF: PatPat SF: Parsons SG: Harden PG: Lin
seriously, if I were another team id low ball offer a trade for him, then say just play home games for now, and then get him an awesome doc and therapist and hope in the future he would be able to fly, if not you dont resign him after his rookie deal, and you still get 40 games a season from a guy who can no doubt play, hes on a rookie contract for not much cash anyway
As a Rockets fan, I have been as optimistic as I can about this situation, but my patience is about as thin as it can get. I completely understand that he has a mental condition that requires special circumstances. But there is a way to handle these situations and a way not to.
Not showing up for practice or games and then tweeting about how badly your employer (who is paying you millions) is treating you is about the worse way you can possibly handle the situation. He either needs to show up for practice and communicate better with the Rockets to the best of his ability or he needs to quit the NBA altogether. The Rockets are no different than any other franchise would be.
And reading his constant tweeting over the last 24 hours, this **** is getting old.
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|Hey Mom! Learn more about the Gerber Life Insurance Grow-Up Plan!
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I had a failed vbac(well not failed, I never got a chance to go into labor). When I found out I was pregnant I found a wonderful midwife and had a hba2c. It was the best choice for our family. I labored so long in denial my midwife arrived 45 min before he was born! Our kids slept thru the entire thing. Woke up to a baby brother. I was never scared of the risks. I was scared I'd fail. And I had many challenges. My broke broke without labor starting. I had 68 hours of broken waters by the time he was born. And he induced naturally with castor oil
Jaelyn(6-16-07) & Dominic (2-4-10)
HBA2C Damian(6-19-12)
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Didn't read anyone else's responses, so just responding to you. :-)
I had DS by cs after an induction and 5 hrs of pushing. He was 10lbs 12oz and had his head cocked to the side with his ear to his shoulder (acynclitic presentation, widest possible diameter), and I had a still mostly intact hymen (it's a mystery to me how!)
DD was born at home - a vbac - after a textbook perfect homebirth. Literally the best thing I could have ever imagined! She was 9lbs 15oz. No complications.
My recovery after both births felt the same. It was rough and I had rough ppd and a rough start nursing with both.
If/when we have a third I feel torn about what we will do. After having my "dream vbac" I realized the actual delivery doesn't mean anything to me compared to how much I love my babies. :-) I love them both exactly the same! And I can see the courageous effort I put into both deliveries.
I'm not comfortable homebirthing again, bc my babies are so big. After having the perfect homebirth and holding my baby in my arms I was really struck by how much I was risking by doing all of this away from emergency care. Especially bc of their size and body shape. They both had wider chests/torsos than heads - by an entire inch (the head is supposed to be the widest part) and babies with that body type are the ones with the worst outcomes in the RARE cases of true shoulder dystocia.
The statistics are largely in favor of a safe delivery, for sure. But when I held my little girl for the first time I finally saw her as MY little girl and not a statistic.
The thought of attempting a hospital vbac (even after a successful hbac) is a little scary to me, so I'm open to scheduling a repeat cs, especially bc we know a third baby would be our last and the main risks of repeat cesareans are to future pregnancies (and to mom).
Those are mythoughts.
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I'm due in Dec and have struggled with my choice for a repeat c/s. DS1 was only 8lbs 7 oz but presented in the same way as your first and sunny-side up. After 36 hrs of labor and 3 hrs of pushing, he was born by c/s with finger marks all over his head from where my MW tried to manually turn him between contractions. This time around, I have GD and an umbilical hernia that NEEDS repaired and my OB feels like I have too many things stacked against me for a successful VBAC although she is willing to let me do a TOL. Unfortunately I am terrified of being another "failure" and going through that torture again only to end up in the OR so I've pretty much opted for the repeat c/s but still keep second guessing myself. I dealt with MAJOR guilt and shame after DSs delivery as I'm the only one in my family to not have an unmedicated natural birth and no one really understood the rough recovery I had. I think, for me, choosing a repeat c/s this time and having time to plan accordingly will at least let me feel somewhat in control of my birth and focus on a healthy baby and self regardless of the delivery method.
OP-best of luck!!! I hope you get the birth that you want and a healthy LO!
Happily married to my prince charming and SAHM to R (2/2010) and L (12/2012)
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Every friend that I've had who has planned a cesarean delivery has shared that it was a very peaceful and gentle delivery and that their babies were alert and able to nurse in recovery. I wish you the best!
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Join Date: Oct 2012
Posts: 6
Re: REPEAT C/S OR VBAC?
I would like to try for a VBAC. I think I'm a good candidate assuming the reasons for my first c-section don't manifest themselves again (I had HELLP syndrome and couldn't risk the blood loss). I didn't mind the csection because it saved my life but in case I want a third child, I would prefer a VBAC due to the risks of multiple cs. However, if my doctor is against a VBAC I will likely defer to their judgment since they have a very low csection rate and are very in favor of as natural birth as you prefer.
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Re: REPEAT C/S OR VBAC?
I had my umbilical hernia repaired during my last c-section! I also have a music playlist that is relaxing and calms me down and warms up the O.R. You can talk with your doctor about kangaroo care when the baby comes. SOme are willing to let the baby stay in the OR with you the whole time and some docs will let you hold the baby too (with some help). I had some issues during the last one and DH had to take Baby Girl with him to the nursery, but I did get to touch her cheek and kiss on those cheeks a bit before that. It was really sweet.
I was also more prepared with coordinating help after my last 2 c/s babies were born (the other c/s was more of a wait and see what will happen). And I was also more prepared by making freezer meals and being ready for post-op recovery (the house was better set up, food was arranged, etc).
So there are perks to knowing what will happen too. That said, I also fully support women who want to VBAC (esp. if you are wanting a large family). I've had some issues from multiple c-sections and it's making me and, especially, my DH struggle with the thought of a 5th child.
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I did a VBAC. For me there was no question, but i hated my c section. I left my long-time OB over it and found one who was really supportive, knowledgable, and specializes in VBACs.
If you go VBAC, it helps tremendously to find a supportive OB. Mine explained to me that there are warning signs before rupture and they can have the baby out ASAP if it comes to that. He also told me that every time he's seen a complication (and never with his patients) there has always been induction involved. He refuses to induce a VBAC.
A good OB will obtain your records from your c section to see if you are even a good candidate for VBAC with regards to uterine rupture.
Good luck with your decision.
Registered Users
Re: REPEAT C/S OR VBAC?
I had a csection with my first for some of thesame reasons you mentioned. I was set on a VBAC but after doing my own research I decided to have a repeat Csection...I felt like it was best for my baby and I still believe that. I am now pregnant with what will be my 5th csection baby...you have todecide what is best for you! And you baby!
Wife to DH for 8 years...Mom to 5 kiddos
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Building Projects in St Paisius Monastery in Arizona
It is with joy that we write to describe the building of our new monastic quarters and guest center.
On the first day of the new year, back in 2001, the sisters of St. Paisius Monastery awoke to their first day on the newly purchased monastery property. Within days, they were already hosting a group of visitors for the feast of the Nativity, celebrated on January 7th. Even bare necessities were still all boxed up but somehow a meal was prepared and all rejoiced. That background scene of trying to make do, while gracefully fulfilling our desire to offer hospitality to those who come, repeated itself time and again over the following decade. For years, the total living quarters in the monastery consisted of a tight 7,000 square feet. Sisters were living in barns and outbuildings, all the while doing their best to offer hospitality to guests, seeking to hide the labor it required for the most minimal of tasks. Food, drinking water, dirty dishes were hauled up and down the back road day after day. Furniture was switched around in rooms to accommodate the pressing needs of the moment, which changed from one day to the next. Underlying all of the many labors was the pressing reality that the monastery (which still just consisted of a ranch house) was not set up to function properly as a monastic center, so even small tasks took great effort.
In 2003, the second floor was added to the main house, enabling all the sisters to live under the same roof. Meanwhile all services were conducted in the dearly loved (but very small!) Chapel of St. Anastasija. Though we barely fit ourselves, we would at times have up to one hundred guests squeezed in as well. Seeing the priority for a larger church as paramount, arduous work on the catholicon began in 2004. Now the catholicon stands as a joy to all.
From year to year the number of guests continues to increase; this year the monastery opened its doors to about 1500 visitors. As a continued response to the growing influx of faithful visiting the monastery, the sisters (of whom there are now 20) have begun the next phase of the monastery's development. This includes the construction of a new building, designed to adequately house the Abbess, the nuns and the young students of the monastery's Holy Protection Home School. Once completed, the original house will become available for a more suitable use as a guest center, including much-needed guest accommodations and an expanded bookstore, with an adjacent room for receiving and greeting visitors. Relocation of the bookstore from its former building will in turn provide more suitable accommodations for the many visiting clergy.
The expansion of our monastic community reflects the will and desire of our ruling hierarch, His Grace Bishop MAXIM, to offer a place of solace and healing for those who visit. We are committed to receiving those who come so as to contribute, in whatever way we can, to the spiritual renewal and healing of those who are seeking it. And this brings us to the main purpose behind the current construction project. The dormitory, designed as a monastic dwelling with separate cells for the sisters, provides an opportunity for the monastic sisterhood to deepen its interior life of sustained prayer—the heart of our monastic calling. Solitude and service—prayerful contemplation and action—might be viewed as mutually exclusive, but in the monastic life, it is quite the opposite. As it is the monastic's greatest service to pray for the entire world and for all those known and unknown to her, so, it is this prayer, humble as it may be, that we hope is our greatest service and spiritual offering. We remain grateful to those who feel led to labor together with us in the establishment of this monastery as a place dedicated to love for God and neighbor.
To those who have already donated of their time and financial resources to begin this project, we offer our sincerest gratitude and our faithful prayers in the monastery's liturgical services. In order to complete the project, we again turn to you and to any who feel led to offer the needed financial support. We humbly rely on your generosity.
Abbess Michaila,
together with the sisters in Christ with me
If you would like to make a donation through PayPal, please follow this link. Or, please feel free to contact us directly.


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Matt Frattin and Phil Kessel each netted third-period goals as the Toronto Maple Leafs edged the Winnipeg Jets, 3-2, at MTS Centre.
Tyler Bozak added a goal and an assist, while James Reimer made 23 saves in Toronto's second straight win.
"We didn't play our best in the first two periods, but it is the road and you got to win however you can and we'll take it," Bozak said.
The win was the Maple Leafs' first in Winnipeg since Nov. 1, 1995, when the Leafs defeated the original Jets, who are now known as the Phoenix Coyotes.
Zach Redmond and Grant Clitsome scored for the Jets, who have lost four of their last five games. Ondrej Pavelec allowed all three goals on just 18 shots.
The Jets took a 2-1 lead 3:46 into the third period when Clitsome's one-timer from the left point made its way through a crowd and into the top-right corner, but Toronto answered with 5:02 left in the frame with Frattin's deflection in front of a Cody Franson one-timer from the top of the right circle.
Winnipeg's Alexei Ponikarovsky was then whistled for holding less than 30 seconds later, and the Maple Leafs converted on the power play when Kessel grabbed a drop pass just inside the blue line and let loose with a wrister from the right circle that snuck inside the near post for his first goal of the season.
The Jets then failed to net the equalizer despite pulling Pavelec for the final minute of play as the Maple Leafs hung on for the victory.
"We struggled a bit in our zone. Even against their fourth line, there was a point there where we struggled." Jets coach Claude Noel said. "Why we're like that, I'm not quite sure."
Winnipeg broke a scoreless tie at the 3:32 mark of the second period while shorthanded as an offensive zone turnover by Toronto led to a 2-on-1 rush for the Jets, which Redmond finished with a wrister from the left circle that sailed past the glove of Reimer.
But Toronto knotted the game at a goal apiece while also shorthanded after Bozak poked the puck away from Winnipeg's Paul Postma at the Maple Leafs' blue line and raced down the ice on a breakaway, finishing with a wrister over the glove of Pavelec just under three minutes later.
Game Notes
Redmond recorded his first career goal ... Jets defenseman Tobias Enstrom had an assist to extend his point streak to eight games. He has two goals and 10 assists during that span ... Jets defenseman Dustin Byfuglien missed his fourth straight game with a lower body injury ... Toronto defenseman John- Michael Liles was playing in his 600th career game ... The Maple Leafs improved to 5-1-0 on the road this season, while Winnipeg fell to 3-2-0 at home.


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Tag: John Patterson
6 Tora Tora – Revolution Day (2011)
Thank You, Tora Tora, Thank You!!! I have been waiting a long time for the follow-up effort to Tora Tora's sophomore effort, Wild America from 1992. I had no idea it would take nearly two decades to have a copy of Tora Tora's Revolution Day in my hands! Tora Tora has finally made their third CD, Revolution Day available for purchase through FNA Records.
You can call it the introduction of grunge to the music scene, or label restructuring, but what ever reason fits, Revolution Day never received a proper release after it was recorded back in 1994. It is a crying shame, as music this good should not have been under wraps for so long.
Revolution Day sees that excellent Tora Tora sound well in tact, but it also shows signs of growth in the band's sound. The guitar work of Keith Douglas really shines on this CD. There are moments on this CD where his playing brings Jimmy Page to mind. The additions of horns into the music, really punches the songs up. Anthony Corder's unique vocals have never sounded better.
From the opening Led Zeppelin like intro of the title track, "Revolution Day", you almost know right out of the gate that you are about to hear something special, and it only gets better. "Revolution Day" should have been a blazing hot tune on the radio back in '94, and a few smart DJ's out there will likely play this now!
"Mississippi Voodoo Child" is so incredibly catchy, it will have you singing along after the first listen.
Some of my other favorites on Revolution Day include the tracks "Blues Come Home To You", and "Little Texas". There truly isn't a bad song in the bunch, and this CD gets better with every listen.
If you have one of those shoddy bootleg copies of Revolution Day that has been circulating across the net for years, you really owe it to yourself to hear the songs of Revolution Day recorded in all of their glory. This is way the CD was meant to be heard!
If you were a fan of Surprise Attack, or Wild America, you are going to love this. I highly recommend picking this up. Kudos to FNA Records for releasing one of the best hard rock records of 2011!
You can purchase Tora Tora's Revolution Day through FNA Records at this link!
Track Listing:
01. Revolution Day
02. Mississippi Voodoo Child
03. Candle And The Stone
04. Blues Come Home To You
05. Time And The Tide
06. Shelter From The Rain
07. Living A World Away
08. Rescue Me
09. Little Texas
10. Memphis Soul
11. Me And You
12. Out Of The Storm
Tora Tora is:
Anthony Corder – Vocals
Keith Douglas – Guitar
Patrick Francis – Bass
John Patterson – Drums


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"Some impressive facts from ign.com on the impact of iPads:
* Over 100 million sold
* iPad sales topped all other PC Manufacturers in the second quarter of 2012
* 94 percent of Fortune 500 companies use iPads "in an official capacity."
Despite these mind-blowing numbers, I am always interested in the discussion of what device is best in an educational setting. Audrey Watters wrote a post this week asking, "Why Tablets?" that got me thinking about this a bit more, especially given the fact that we currently have over 1,200 iPads in Burlington, a number that will soon be over 2,000 as we deploy iPads at the middle school level."