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The 17th-century building sat last Wednesday morning on Fort Hill Street in Hingham, but by the end of the day it had entered a new chapter in its history, 1½ miles away on Lincoln Street.
As crews shepherded the 19-foot-tall building along the journey to its new site, drivers in passing cars watched with open mouths, and spectators trailed alongside the slowly moving structure.
"It's been very interesting," said Andrea Young, Hingham's preservation administrator. "The real story is how people came together and volunteered their time. That was most gratifying."
Moving the historic munitions depot from 99 Fort Hill St. to the property of the Old Ordinary Museum on Lincoln Street has been the focus of history-loving minds since the house faced demolition last fall.
Yet a demolition delay bylaw, mandating a waiting period before historic buildings would be razed, enabled the town to come together to act.
"Probably without that delay, we wouldn't have been able to save the house," said Tom Willson, chairman of the Hingham Historic District Commission. "The delay gave us the possibility, the likelihood that we could bring the coalition together. Someone ultimately came up with the idea that it would fit [on Lincoln Street] wonderfully as a museum of a 17th-century house. The historic society was enthusiastic about keeping it. It just worked out."
The building had been hoisted onto a flatbed truck by Tuesday. Then on Wednesday, with police escorts to stop traffic, a bevy of utility crews normally seen only during storms, and professional movers, the house made its way through several winding Hingham roads, squeezing under moved wires and knocking down a few skinny branches along the way.
The house finally came to rest behind the Old Ordinary Museum, and will remain closed until funding can be found to place the property on the lot and turn it into a museum.
The fate of the house is a fitting one.
Previous owner John Richardson was a noted Hingham historian, who dedicated his life to the study of the small South Shore suburb.
He lived in the old fort from 1965 until his death in 2011, and his collection of antiques, town records, photos, and notebooks lined the house wall to wall.
"I'm thrilled it's being preserved. It's what he wanted," said Sarah Asnes, Richardson's niece. "He wanted it all turned into a museum. We couldn't do it all ourselves. We're normal people. So we worked with the historic society and the historic commission to preserve the oldest part of the house. We donated tons of his stuff so they can set it up with all his antiques."
The house will be Richardson's legacy, said his sister Joyce Ciccolo. Still, it was both weird and rewarding to see the house start down a new path — literally.
"It's really wonderful. It was happy and sad both today," she said.
Interestingly enough, the house had been moved before.
Constructed in 1685 by Captain Thomas Lincoln, the building was a munitions depot within what is now the Fort Hill Cemetery, serving to fend off natives during King Philip's War. By 1730, the building had been moved to 99 Fort Hill St. and converted into housing.
A number of owners would pass through its doors, including the Stowell, Hersey, Binney, Manuel, Spring, and Cain families. The Bouve family owned the property from 1938 to 1965, but did not live on the premises.
From fort to home, the building will change uses once again to become a museum and an example of first period architecture. The building is also the only remaining fort from early settlements in the United States, local historians say.
Yet the value of the building is bigger than its singular place in history.
"That story of Hingham is a story that isn't often told, I think, in New England and the US, because we tend to focus on exceptional histories," said Suzanne Buchanan, executive director of the Hingham Historical Society. "We focus on Salem and the witch trials; on the East Indian trade; Plymouth, the whole history of the Pilgrims. But here is Hingham, this little working town, fishers, farmers, builders, plugging away, for centuries in a very Yankee kind of context. People rarely moved out of their houses."
"That stability is a story in and of itself. And walking around Hingham you get that snapshot sometimes, with a little imagination, what it was like to live in a community."
The house is part of that context, and the documents compiled by Richardson, put side to side with genealogies and thousands of historic photographs, create a fascinating glance at daily life, Buchanan said.
Though a master plan for the building is still in the works, and neither a funding source or timeline has been specified for the building's permanent location and renovation, those involved in the process are optimistic of what future history books will say about the property.
"I think they all really want it to happen," Ciccolo said of the plans. "They worked really hard."Jessica Bartlett can be reached at firstname.lastname@example.com.


text: Mark your calendars today to save Friday, November 15th to attend the 15th Annual Miracle on Main in downtown Reinbeck. The committee has put together a myriad of activities to appeal to participants of all ages. Watch the paper in the coming weeks for a glimpse into what has become Reinbeck's gateway to the holiday season.

subset: commoncrawl


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Surgical treatment of hip fractures in Norway. The Norwegian Hip Fracture Register
(The University of Bergen, 2009-04-17)
Each year in Norway, approximately 9,000 patients are hospitalised and operated on due to hip fractures (femoral neck fractures, trochanteric fractures, and subtrochanteric fractures). There are several treatment methods ...
Wear, fixation, and revision of hip prostheses
(The University of Bergen, 2007-01-19)


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For those of you not familiar with it, in March, 2006 CowherdItSomewhereElseFirst "borrowed" one of our bits, read it on his radio show without attribution, then wouldn't give credit when he was called out on his act of douchebaggery.
At the time, the story actually became pretty big news in the sports blogosphere as bloggers rallied to our defense and some in journalism quarters noted it due to the ethical questions Cowherd's actions raised.
In any event, since I had not read the book, Craig was kind enough to send us the excerpt:
COLIN COWHERD: "That 'end zone' thing was really just nothing. That was more Internet babble. I read something that somebody sent to me anonymously. I'd never seen it before. I just said, 'This is funny,' and then we read it on the air. We didn't know who it was. And then we got a bunch of people e-mailing us and killing us for it, and after a while I e-mailed back to somebody and said, 'Come on, dude. Get over it. We get it. We made a mistake.' And then I wanted to apologize, and the company said, hey, they wanted to review the situation. ESPN's an aircraft carrier, not a sailboat. Our turning radius is pretty slow; when controversy happens, it takes twenty-four or thirty-six hours to get everybody huddled, listen to the tape, see what they think. So I would have apologized immediately but management said, 'Stay away from it for twenty-four hours, then we'll address it.' And I did. But that was nothing."
Shales, Tom (2011). Those Guys Have All the Fun: Inside the World of ESPN (p. 620). Little, Brown and Company. Kindle Edition.


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Sex assault charges against a former Northern Illinois University police officer were dropped Tuesday after new revelations of possible irregularities in the investigation surfaced, the officer's attorney said.
The charges against Andrew Rifkin were dropped following a hearing where a campus police IT specialist testified that he was summoned around 10 p.m. on Nov. 9, by NIU Police Chief Donald Grady and was told to remove between 60 and 70 files from the chief's computer, Rifkin attorney Bruce Brandwein said.
Earlier that day, university administration had appointed a new supervisor to oversee Grady and the department. That same day, a DeKalb County judge had ordered the NIU police to sign an affidavit confirming that all evidence in the Rifkin case had been handed over to county prosecutors, following a previous finding that the department had withheld evidence.
Grady was placed on administrative leave the following day.
Brandwein said the specialist did not know whether the files he removed pertained to the Rifkin investigation, but Brandwein said he found the timing curious. After hearing about the removal of the files, DeKalb County State's Atty. Clay Campbell told the judge that prosecutors would drop the charges against Rifkin, Brandwein said.
"It was incredible," he said. "I applaud the state's attorney for doing the right thing."
An attempt to reach Campbell for comment was not successful Tuesday night.
Rifkin, 25, was fired from the department in October 2011 after it was alleged he sexually assaulted an NIU student. However, the NIU police's investigation of the case came under fire this month when it was learned that the department had failed to turn over reports of witnesses who indicated that Rifkin and the student had engaged in consensual sexual activity.
Those reports ended up in a personnel file in what the NIU police said was an oversight. But DeKalb County Judge Robin Stuckert called it an "egregious" error and ruled that the department had purposely withheld the evidence.
That prompted university officials to place Grady on leave, pending a final disciplinary action. NIU also said it plans to terminate the officer who conducted the investigation against Rifkin.
Twitter: @chicagobreaking


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SEOUL — Park Geun Hye, the presidential nominee of South Korea's ruling party, said Monday that she wants to meet North Korean leader Kim Jong Un to improve relations if she wins next month's election.
''I am willing to meet the leader of North Korea for the advancement of inter-Korean relations,'' Park said at a televised press briefing in Seoul to announce her foreign affairs and national security policy pledges.
Park, whose mother was killed in 1974 during a North Korean assassination attempt on her father when he led South Korea, pledged to reverse outgoing President Lee Myung Bak's hard-line stance against Kim's regime. North Korea two days ago blasted the ruling New Frontier Party and said ties would worsen if Park is elected.
The 60-year-old Park is seeking to become the first female leader of Asia's fourth-largest economy in the Dec. 19 vote.
She is outpolling two challengers in her bid to succeed Lee, whose approval ratings have plummeted. She is seeking to revive a party hurt by scandals by promising to address a widening income gap, create jobs in the technology industries, and expand welfare spending.
On Monday, Park called for installing offices in Seoul and North Korea's capital of Pyongyang to improve communication and said she would form a crisis management bureau to centralize control over national security, diplomacy, and unification issues.
She said she would help North Korea join global financial and trade organizations, and pledged assistance in promoting foreign investment into the totalitarian state.
North Korea's Secretariat of the Committee for the Peaceful Reunification blasted the New Frontier Party as ''a source of disasters of the nation and the root cause of all misfortunes,'' in a Nov. 3 statement carried by the official Korean Central News Agency.
Relations will be ''worse than what they were during the Lee regime'' if Park is elected, according to the statement.
Park served as acting first lady after her mother was killed in the assassination attempt on her father, Park Chung Hee. The elder Park was South Korea's longest-serving military ruler until he was killed by his deputy and intelligence chief in 1979, ending an 18-year dictatorship.
Park Geun Hye's approval rating stood at 42.8 percent, ahead of independent candidate Ahn Cheol Soo's 26.8 percent and main opposition party candidate Moon Jae In's 23.6 percent, according to a weekly poll by Seoul-based Realmeter.
Moon and Ahn will meet Tuesday to discuss joining forces to secure an opposition victory next month, Ahn's spokeswoman Chung Yeon Soon said in a text message.


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Holland Phillips serves as the principal violist of the Salem Chamber Orchestra and the Eugene Symphony. Reviewers have praised the "spirit and clear tone" of her playing (Leipziger Volkszeitung) and the "serious intensity" that she brings to performances (Register-Guard). She also performs with other Oregon-based ensembles: Chamber Music Amici, TARDIS Ensemble, Oregon Mozart Players, and Oregon Bach Festival. In 2012 Ms. Phillips completed her doctoral studies at the University of Oregon with her dissertation, "Tidens Fylde: Temporality and Tradition in Carl Nielsen's Works for Violin." She also holds degrees from Vanderbilt University and the New England Conservatory. Her principal teachers include Dr. Leslie Straka, James Buswell, Kathryn Lucktenberg, and Connie Heard.
- 1996: H.S. diploma: North Carolina School of the Arts, Winston-Salem, NC
- 2000: B.M. Vanderbilt University, Nashville, TN
- 2003: M.M. New England Conservatory, Boston, MA
- 2004: G.D. New England Conservatory, Boston, MA
- 2011: M.M. (viola) University of Oregon, Eugene, OR
- 2012: D.M.A. (violin, musicology) University of Oregon, Eugene, OR


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Like many of us, I have kept up with the stories of Rita Crundwell. I was always somewhat incredulous as to how it may have happened, but it did.
This month's Chicago magazine has a multi-page article on the whole fiasco, and it brought it all up again. We should be embarrassed. It almost hurts to read it. The whole story is so far-fetched that it could not be real, or could it? Sadly, yes.
What also strikes me is that no one has been fired, demoted or even scolded. I have known Mayor Burke for a number of years and believe him to be an honest sort, but given the scope of what transpired, he should have resigned along with the rest of the staff. It would have been the honorable course of action.


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Samantha Stosur was in irresistible form as she beat top seed Victoria Azarenka 6-2 6-3 to win the Southern California Open in Carlsbad.
Amazingly this was the Australian's first tournament win since defeating Serena Williams to lift the US Open back in 2011, and only the fourth title of her career.
Her opponent Victoria Azarenka just never got going, and couldn't get a grip on the match at any stage.
Overall the Belarusian can be pleased with her week's work considering this was her return from the injury sustained at Wimbledon back in June, but she'll want to forget this performance, as she was completely
Having broken back at the first time of asking at 2-0 in the first set, Azarenka then let her serve slip again as Stosur went on to convert all three of her break points in the first set.
This was in stark contrast to Azarenka, who just couldn't grasp the opportunities she made for herself. Stosur dominated the big points, managing to claw her way out of trouble when she needed to.
The second set followed a similar pattern to the first, as Azarenka struggled to control her serve, hitting seven double faults in the match, and disappointingly, only hitting one ace.
Stosur had never beaten Azarenka in their eight previous meetings but at last she was able to break her duck against the world number three, but it could have all been different had her opponent been able to convert more of her break points.
As it happened, Azarenka converted just one of her twelve break points. Stosur however, was far more prudent in this regard, converting four of her five break points as she came up trumps when it mattered.
Stosur defeated Sesil Karatantcheva, Agnieszka Radwanska and Virginie Razzano on her route to the final. After this impressive performance, there is no reason why she can't regain her US Open crown if she can keep up this kind of form. Obviously Serena Williams would have something to say about that.
Despite this defeat, Azarenka climbs above Maria Sharapova to world number two, whilst Stosur, who had had a relatively indifferent year up to this point, climbs up to just outside the top 10 to 11th.
Victoria Azarenka will hope that this performance was just a blip, whereas Sam Stosur will know she must keep up this kind of form if she wants to challenge for Grand Slams again. But can Stosur still mount a challenge on the world's biggest stages?
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Maple Pork Slices Recipe
Lori Comstock of Chesterfield, Virginia combines fresh garlic, herbs and sugar-free maple syrup to turn pork tenderloin into a distinctive entree. "The touch of sweetness makes the meat dish a big hit with my family," Lori says.
VERIFIED BY Taste of Home Test Kitchen
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- 1 pork tenderloin (1 pound), cut into 1-inch slices
- 1 garlic clove, minced
- 1 teaspoon dried marjoram
- 1 teaspoon dried thyme
- 1/4 teaspoon salt
- 1/4 teaspoon onion powder
- 1 tablespoon butter
- 2 tablespoons sugar-free maple syrup
- Flatten meat to 1/2-in. thickness. In a resealable plastic bag, combine the garlic, marjoram, thyme, salt and onion powder. Add pork, a few slices at a time; shake to coat.
- In a nonstick skillet, cook pork in butter over medium heat for 2-3 minutes on each side or until meat is no longer pink. Drain and discard pan juices. Add syrup to meat in skillet. Cook over medium-high heat, turning several times, for about 3 minutes or until syrup is absorbed. Yield: 4 servings.
Originally published as Maple Pork Slices in Light & Tasty February/March 2004, p43
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Visit the pattern department in store to browse our patterns available in store.
SHIPPINGShipping your purchase is easy at JOANN! Orders typically leave our warehouses within 1-3 business days (Mon-Fri). Delivery date depends on the destination address and the shipping method. You'll receive an email with tracking information when your order is shipped.
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August 31 – Happy Birthday Eddie Plank
The 1917 season had ended, Miller Huggins had just taken over as manager of the Yankees and he was intent on completely re-hauling New York's underachieving roster. The new skipper desperately wanted to add a good second baseman to his new team's lineup. That second baseman's name was Del Pratt, who was playing for the St. Louis Browns at the time and was considered the second best player at that position in the American League, behind only the future Hall-of-Famer, Eddie Collins. Huggins got the permission of Yankee co-owner, Jacob Ruppert, to send three Yankee starting position players and two of the team's younger pitchers to the Browns for Pratt and the future Hall-of-Fame pitcher Eddie Plank. The problem was that Plank, who was already 42-years-old at the time, had already told the Browns he was retiring. Huggins knew that but he told Ruppert he could talk the veteran southpaw out of quitting to pitch for New York.
Plank had spent the first 14 years of his brilliant career pitching for Connie Mack's Philadelphia A's. He had perfected a distinctive cross-body, side-arm pitching motion that helped him win 326 games and throw 69 shutouts. Though he pitched in an era of pitching legends and was often pushed out of the headlines by the likes of Cy Young, Christy Matthewson and Walter Johnson, "Gettysburg Eddie" was as good as it gets on a Major League pitching mound. To visualize Plank at work, think of Mark Fydrich. Like "the Bird," Plank employed constant motion and muttering on the pitching mound. When he wasn't tugging at his jersey, tightening the laces on his spikes or furiously rubbing up the baseball, he'd be talking to himself, the batter, his catcher, the ump or anyone who'd listen to him. If you're one of the many who thinks it takes Josh Beckett too long to throw a pitch, you'd probably would have been screaming at Plank. He could take forever to agree on a sign with his catcher and God forbid if there was a runner on first base because Eddie would often just stare at him until the player shortened his lead or Plank's stare lulled him to sleep and he picked the guy off.
In 1915, Plank had abandoned the A's and jumped to the rival Federal League to play for the St. Louis franchise, where he won 21 games. When that franchise went under, its owner purchased the Browns and brought Plank back to the AL. Though he was able to win 16 games at the age of 40, the years were catching up to him and when he went 5-6 for St Louis in 1917, he told the team he was going back to his farm in Pennsylvania and staying there.
Huggins assured the New York sports press that he would convince Plank to pitch again in 1918. The Yankee skipper's plan was to stop by Plank's farm on the way to spring training, make him an offer he couldn't refuse and bring Plank south with him. But when Huggins arrived at spring training he was alone and Plank was still on his farm. The Browns sent the Yankees a rebate check for $2,500, a great career was over and the newest Yankee was never a Yankee after all.
This former Yankee outfielder shares Plank's August 31 birthday.


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Submission + - Researchers bypass spinal cord paralysis with brain-computer interface (extremetech.com)
MrSeb writes: "Scientists at Northwestern University in Chicago, with funding from the National Institutes of Health, have successfully bypassed the spinal cord and restored fine motor control to paralyzed limbs using a brain-computer interface. The researchers have created a neuroprosthesis that combines a brain-computer interface (BCI) that's wired directly into 100 neurons in the motor cortex of the subject, and a functional electrical stimulation (FES) device that's wired into the muscles of the subject's arm. When the subject tries to move his arm or hand, that cluster of around 100 neurons activates, creating a stream of data which can then be read and analyzed by the BCI to predict what muscles the subject is trying to move, and with what level of force. The end result is a computer network that effectively replaces the nervous system and restores remarkably accurate fine motor control to a paralyzed arm. The subject, in this case, was a rhesus monkey rather than a human — but our anatomy is very, very similar to that of our primate cousins. The research paper notes that, worldwide, 130,000 people per year sustain spinal cord injury — with half of those becoming paralyzed from the neck down. Many of these could be helped with such a neuroprosthesis."


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Unlike previous games of Blitz, which came across like a pickup game of football with NFL players in stadiums, Blitz Pro focuses on a more realistic, simulation style 11-on-11 game of pigskin. Gone are the days of 1st and 30, and get ready for 1st and 10 gains again. Along with the refocusing of the yardage scheme, Blitz Pro welcomes the addition of a running game, something that has been missing from the series (some would argue) since its inception. It's now a conceivable option to perform a sweep for a considerable gain just as it used to be easy to throw for 15 or 20 yards in previous Blitz games.
However, you won't be able to rest on your laurels, because the AI for the game has been boosted significantly, enabling defenders to sniff out run or pass plays and adjust their protection accordingly. The fast and loose style that once controlled the game has been reined in significantly, meaning that the number of wild fumbles, massive numbers of interceptions and off the wall untouchable catches. This can be exceedingly tricky for veterans of the Blitz series to get used to; considering the accelerated speed of the computer, quarterbacks no longer have the luxury of sitting in the pocket and getting a player open. Such conservative control will only result in numerous sacks and punts. That's right, you'll also have to worry about special teams in Blitz Pro, including physically attempting field goals.
Fortunately, players can use impact players to even their chances for big plays. Typically selected from the big offensive and defensive stars of a particular team, the impact player can be used to drop back and pass protect, go on an "audiblized" pass route, or delay a rush on the quarterback, amongst other things. Throw in a widely expanded number of playbooks (each one unique to every team) and you have a re-envisioned form of Blitz football. Yet, while there has been a lot of attention paid to bringing up Blitz's loosened approach to the sport, the outlandish features of the game still remain. Players retain the option to stomp mudholes in any running back or wide receiver foolish to cross the line of scrimmage with the football, just as players have the option to showboat their way down the sideline towards the endzone. The boost meter makes its return once again, which can be used to shake off opposing players or give a back a jolt of speed. Oh yeah, and those players in the zone still catch on fire, too
Aside from the typical quickplay or exhibition modes, which allows you to play a match between any of the NFL teams on any of the gridirons around the league (in any weather condition), gamers can establish a number of tournaments against computer or human opponents to see which team is best. They can also create a player or establish their personal info to keep track of their wins, losses and other statistics. Now, however, season and franchise modes have been boosted and added, respectively, leading to a more "Madden"-esque feel to gameplay. These modes include a fantasy draft, personal player stats, and other managerial tasks. Successful games or seasons can net you cash that can be used to purchase new fantasy teams, stadiums, game modes or upgrade player stats in the Blitz shop.
Stadiums and field effects in Blitz Pro look particularly nice, showing a particular attention to detail that hasn't really been seen in previous Blitz titles. Unfortunately, if you're looking for anything in particular to distinguish between football players, you're not going to find it here. Blitz Pro features similar character models for every player on the field; hell, even kickers seem huge in this game, which is obscene in today's league. Animations of tackles, catches and celebrations are wild, and still evoke the similar laughter and cringing from previous games. However, other animations come across rather wooden and stiff, especially before boosts or other rule breaking moves are enacted.
Sound is just as mixed as the graphics, which is unfortunate. Hits still sound particularly painful in the game, which is exactly what you'd want to hear from a fierce game like this. Other sound effects seem appropriate to the onscreen action, but that's about all. The music, while pulling from popular licensed rock artists, is very limited, with only four tracks constantly playing in the background. Needless to say, this gets very old very fast. The commentary falls into this trap as well. While the color commentator and play-by-play announcer are hilarious, and come with great material, you'll notice that they tend to repeat themselves often, meaning that the amount of lines for these comedians is rather shallow.
Shallow, in fact, is the perfect term for gameplay in Blitz Pro, because it feels like the designers lost focus with what they were trying to develop for the game. To this end, the amalgamation of realistic, simulation football and over-the-top, arcade smashmouth gaming doesn't go far enough in either direction. For instance, there's a draft, but no training camp. There are trades, but they're so exorbitant that they're unrealistic within franchise play. What's worse, you may work hard at saving up a ton of money to upgrade a player, simply to have that guy retire shortly thereafter. Simply put, this blows. Plus, the inclusion of kicking meters for special teams is way too loose and uncontrolled. I don't mind trying to line up a scrolling bar in the green area in the kick meter, but there's no explanation for the green area to consistently move from kick to kick. Additionally, some sections of the "successful" green bar cause catastrophic failures or inaccurate kicks. This system needs to be worked on or eliminated entirely.
The extreme action feels somewhat toned down also
Now that you actually have to worry about always picking up 10 yards and establishing running games, the rush of adrenaline previous Blitz titles provided seems to be missing. If I'm playing a Blitz game, I don't care about tracking player's stats and trying to improve them; I want to rip an opponent's head off. This is highlighted by the inclusion of Classic Blitz within the Blitz shop, which shows just what's lacking in this year's version. Tackling players feels sufficient, and the bodyslams, choke holds or other moves almost feels superfluous. Unfortunately, unlike Midway's other "realistic/extreme" sports title, NHL Hitz, there's no option to tweak the gameplay settings, meaning what you see is what you've got. (As a side comment, it takes way too long to load a game or even switch screens between plays, which is inexcusable, especially on an Xbox.) The final straw that breaks Blitz's back is the lack of serious multiplayer options, with the exception of the PS2, which doesn't provide a lot of depth. Downloading similar weather conditions or updated rosters with accurate stats isn't going to improve the quality of the game or impart new features to gameplay. This means that your major competition, aside from the computer, will have to be a friend. However, both of you will probably find yourself switching football games quickly.
Fans of the Blitz series were alarmed when it was announced that Blitz Pro was going to be more realistic this year, and rightfully so. Players not interested in statistics or hardcore accurate football liked the cartoonish, inflated violence that Blitz provided. Unfortunately, the inclusion of half-hearted simulation elements and toned down arcade gameplay result in Blitz Pro turning into a watered down shadow of its former self. Hopefully next year's version will restore some glory to this now tarnished franchise.
Rating: 69%
Written By: Jeff 'Linkphreak' Haynes
Game Over Online - http://www.game-over.com
Ask any football fan what their favorite part of the game is, and you'll probably get a range of answers: the strategy of the game, the beauty of the pass versus the power of the run, the drama of close games and propensity for last minute heroics. However, all fans can't deny their love of bone crushing hits. They're almost like car accidents waiting to happen; you don't want to watch, but you just can't turn away. Why else would ESPN run a segment on their Monday Night Countdown show called "Jacked Up," featuring the meanest impacts of the week? NFL Blitz was created to capitalize on this desire for pain, with an over the top focus on crushing your opponents, and quickly became a fan hit. So you can imagine their shock when it was announced that the latest game in the series would take a more realistic tone. Get ready to eat some grass with the new football title from Midway Sports, NFL Blitz Pro.
Fans of the Blitz series were alarmed when it was announced that Blitz Pro was going to be more realistic this year, and rightfully so. Players not interested in statistics or hardcore accurate football liked the cartoonish, inflated violence that Blitz provided. Unfortunately, the inclusion of half-hearted simulation elements and toned down arcade gameplay result in Blitz Pro turning into a watered down shadow of its former self. Hopefully next year's version will restore some glory to this now tarnished franchise.
Back to Game Over Online


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When ACC commissioner John Swofford called Monday, Virginia football coach Mike London anticipated a reprimand for his criticism of officials. Far from it.
Swofford informed London that he is the conference's 2011 Coach of the Year.
After Tuesday's public announcement, London said he was "humbled" by the award and credited his players and staff.
"More than anything I am extremely proud of the performance by our players and coaches this season," he said. "This is really a reflection on their efforts this year. Quite honestly, I do not think there were very many people outside of our locker room who felt we could go into the final week of the season with a chance to advance to the ACC championship game. As a coach, you live for the kind of moments where your team buys in, puts in the work and the effort and sees the positive results that come from it.
"We accomplished so many things this year and grew into a team that believed in itself and was confident about what it could achieve on the field. We went from just trying to win a game to managing to win four on basically the last play. That builds a lot of character."
Virginia is the ACC's most-improved team this season. With upsets of nationally ranked Georgia Tech and Florida State, the Cavaliers (8-4, 5-3 ACC) remained in contention for the Coastal Division title until Saturday's 38-0 loss to Virginia Tech. This following a 4-8, 1-7 finish in 2010, London's debut season.
Virginia is poised to reward that progress. London said that he and the school are negotiating a contract extension that will keep him with the Cavaliers "for a long time."
London's original deal was for five years with annual compensation of approximately $1.7 million. He said university president Teresa Sullivan has made a "commitment" to him and that he is equally committed to Virginia.
While U.Va.'s administration appears willing to bump London's salary, I don't believe the school will repeat the mistakes it made with former basketball coach Pete Gillen and former football coach Al Groh. Virginia overpaid for both, saddling itself with considerable buyouts when those programs bottomed out.
Nor do I believe London is job-hunting -- ESPN floating him for Penn State notwithstanding. He's a Virginian, and neither he nor his family wants to relocate again.
In balloting by the Atlantic Coast Sports Media Association, London received 31 of 45 votes. Virginia Tech's Frank Beamer had 12, Clemson's Dabo Swinney two.
Beamer's Hokies (11-1, 7-1 ACC) overcame a rash of defensive injuries to defend their Coastal title and reach the conference championship game for the fifth time in seven years. Swinney's Tigers (9-3, 6-2) won the Atlantic Division for the second time in three seasons.
A Bethel High graduate, London joins Bill Elias (1961), George Blackburn (1968), George Welsh (1983, '84, '89, '91, '95) and Al Groh (2002, '07) as Cavaliers coaches to win the honor. Like London, Welsh and Groh received the award in their second years at Virginia.
The Cavaliers' nine coaches of the year are more than any ACC program. Clemson, Maryland and Wake Forest have eight.
In 2008, his first season as a head coach, London earned national Coach of the Year honors from the American Football Coaches Association for guiding Richmond to the Championship Subdivision national title.
London is the first African-American to win the ACC award. Conference football programs have employed only three other black head coaches: Wake Forest's Jim Caldwell (1993-2000), Miami's Randy Shannon (2007-10) and North Carolina interim Everett Withers (2011).
This season media picked Virginia to finish fifth among six teams in the Coastal Division. But thanks to marked progress, especially on defense, the Cavaliers used a four-game winning streak late in the regular season to vault into title contention. They tied Georgia Tech for second in the division.
Virginia is bowl-eligible for the first time since 2007, and its most likely postseason destination is the Music City Bowl, scheduled for Dec. 30 in Nashville, Tenn. The Cavaliers defeated Minnesota in the 2005 Music City.
For what it's worth, I voted for London. Beamer, who won the award in 2004 and '05, did another outstanding job this season, but coach of the year honors often go to those who most exceeded expectations, and there London had no equal.
"I am both honored and humbled by this selection," London said. "I greatly respect the coaches in our conference and you could argue there are others who are deserving of this recognition."
I can be reached at 247-4636 or by e-mail at firstname.lastname@example.com. Follow me at twitter.com/DavidTeelatDP


text: hehehhee, what can I say??? I don´t need to keep on using perfection as adjective but I can tell you for me Jesse is....."The Sweetest Thing" the reason why I watch Supernatural and be aware guys!!! if a man says his favorite body part is his cock is because he must be very proud of his dick´s size...so Jesse make a softporn film and show us your nice hung buddy!!! Please!!!!!!!!!!For the Fans!!


text:
As thousands of spectators watched, Nevada's M.S. Dixie II edged California's Tahoe Queen in the sixth annual Great Lake Tahoe Sternwheeler Race.
The 450-passenger Nevada boat beat its 500-passenger California rival by nine seconds Saturday over the six-mile course off South Lake Tahoe in the closest finish ever in the series.
The Nevada sternwheeler won for the first time in three years to take a 4-2 series lead.
Billed as the only authentic race of its kind west of the Mississippi River, the contest pits the two largest paddlewheelers at the Sierra lake straddling the California-Nevada border.
The Zephyr Cove, Nev.-based M.S. Dixie II and South Lake Tahoe-based Tahoe Queen haul tourists to Emerald Bay and other popular attractions at North America's largest alpine lake.
The Nevada boat's winning time was 35 minutes, 20 seconds. The California-Nevada line serves as the race's start and finish line.
Both sternwheelers were filled to capacity with visitors, many of whom wore 1800s-period costumes. Among them was actress Loni Anderson, who was aboard the Tahoe Queen.
The race kicks off an annual Labor Day weekend celebration at Tahoe that also includes air and fireworks shows.


text:
The Gravesend, Brooklyn Handicap 1904 [07:21]
The Brooklyn Handicap in Gravesend, Coney Island, Brooklyn, May 26, 1904 American Biograph & Mutoscope Co. Camera: GW "Billy" Bitzer Coney Island's Gravesend Race Track opened in 1887 and remained in operation until 1910. The first 'Handicap' was a 1 1/4 miles left-handed race on dirt and became part of the 'Handicap Triple' which today is preceded by the Metropolitan Handicap and followed by the Suburban Handicap. The Brooklyn Handicap is an American Thoroughbred horse race run annually in early June at Belmont Park in Elmont, New York, on Long Island. It currently is a Grade II event open to three-year-olds and up willing to race one and one-half miles on dirt. The first segment of this film begins with the horses and their entourages entering the track and getting organized. The handicap seen here begins at 4:00 viewed in five edits, each view is from a stationary camera with virtually no panning. The racing segment itself lasts two minutes with the last minute of film focused on The Picket in what I presume is the winners circle. The Picket was ridden by Jockey Oscar Helgesen who took the prize in 2:06.60. The Picket was trained by Carroll B. Reid and owned by Waldeck Stable. Four horses have won the Handicap Triple: Whisk Broom II (1913), Tom Fool (1953), Kelso (1961), Fit to Fight (1984). 01/05/12 - 3
Tags: newyorkcity, new york city, nycny, nyc, ny, gravesend, coney island, brooklyn, king's county, horse, horses, equestrian, handicap, thoroughbred, flat racing, dirt, left-handed, picket, jockey, oscar helgesen, carroll b. reid, waldeck stable, actuality, ac
Horse Racing at Sheepshead Bay, Brooklyn 1897 [00:29]
Edison Manufacturing Co. Filmed June 22, 1897, at Sheepshead Bay Race Track, Coney Island, New York. From Edison films catalog: The finish and weighing out of a running race with nine starters, won by famous Clifford, Sloane up. Sheepshead Bay Race Track was an American thoroughbred horse racing facility built on the site of the Coney Island Jockey Club at Sheepshead Bay, Brooklyn. Old railroad track diagrams for the Long Island Railroad spur that served both the club and the racetrack show the entrance to the club was located on the east side of Ocean Avenue between Avenues X and Y. The racetrack was built by a group of prominent businessmen from the New York City area who formed the Coney Island Jockey Club in 1880. Led by Leonard Jerome and the track's President, William Kissam Vanderbilt, the Club held seasonal race cards at nearby Prospect Park fairgrounds until construction of the new race course was completed in 1884. - excerpt from wikipedia Sheepshead Bay Neighborhood in southeastern Brooklyn, overlooking an ocean inlet of the same name to its south and bordered to the north by Marine Park, to the east by Shellbank Creek, to the south by Manhattan Beach, and to the west by Gravesend. The area was the site of a large Canarsee Indian village and remained undeveloped for more than a century and a half after the English settled Gravesend in 1645 only a short distance to the northwest. During the 1870s John Y. McKane, the notorious political ''boss'' of Gravesend ...
Tags: newyorkcity, new, york, city, nycny, nyc, ny, brooklyn, sheepshead, bay, brighton, beach, gravesend, coney, long, island, railroad, lirr, horse, racing, race, thoroughbred, equine, equestrian, clifford, starters, track, ocean, avenue, jockey, club, actual


text:
03 April 2007 06:45
HubbleSite - Picture Albumby 2 others
search & index | about us | contact us | copyright
1 (1 marks)
Founded in late 2003 and heartquartered in France, we are non-profit and independant.
We believe in the open web, think internet services should be sustainable, build for the long term.
While we are re-launching the service, we only accept new members through invitation.


text:
FORT DETRICK, Md. - The new Armed Forces Reserve Center here officially opened for business during a ribbon-cutting ceremony March 13.
The event was hosted by Maj. Gen. William Monk III, commanding general of the Army Reserve's 99th Regional Support Command, headquartered at Joint Base McGuire-Dix-Lakehurst, N.J.
Attendees included Julianna Albowicz representing U.S. Sen. Barbara Mikulski, Bud Otis representing U.S. Rep. Roscoe Bartlett, Josh Russin representing Lt. Gov. Anthony G. Brown, Frederick County Commissioner President Jan H. Gardner, Frederick City Aldermen Shelley Aloi and Karen Young, and former U.S. Rep. Beverly Byron.
"I welcome all of you here today to be part of this very important ribbon-cutting ceremony as we take another step in ensuring that our Citizen-Soldiers and Marines have the best possible facilities in which to prepare to fight and win our nation's wars," Monk said to the crowd gathered inside the new Armed Forces Reserve Center.
The center will be home to the Marine Corps Reserve's Company B, 4th Light Armored Reconnaissance Battalion, the Army Reserve's Company A, Detachment 1, 392nd Expeditionary Signal Battalion, and the Army Reserve's 27th and 21st Military History Detachments. The Marine company, which is currently deployed to Afghanistan, will be the AFRC's largest tenant.
"To all the Soldiers and Marines here today who will call this center home, I challenge you to make the very best use of this wonderful gift your nation has given you," Monk said. "Use it to train hard and to be ready - ready to answer the call to duty, as if you knew the hour and the day that call will come."
Also speaking at the event was Col. Jeffrey Davies, chief of staff for the U.S. Army Medical Research and Materiel Command.
"This new facility stands as testimony to our commitment to this mission and the many dedicated men and women who serve our nation in the reserve component," Davies said. "The Marines and Soldiers who occupy this structure now have a state-of-the-art facility with maintenance bays, a weapons simulator training room, an outstanding fitness center, classrooms and administrative space to facilitate the required training as they prepare for their respective missions."
The $14-million, 58,600-square-foot AFRC and its accompanying Organizational Maintenance Facility are located on Fort Detrick's Area B, replacing the Flair Memorial AFRC and its organizational maintenance shop in Frederick. The new facility - a result of 2005 Base Realignment and Closure Commission recommendations - will provide service members educational support, assembly areas, a library and learning center.
"This re-stationing is a fiscally wise move; always an important goal, but especially so in these economically challenging times," Monk explained. "It will allow the Department of Defense to save millions in sustainment, renovation and modernization funds on old, outdated facilities and focus those monies instead on other critical needs to better support our forces, recruit quality personnel, modernize equipment and infrastructure, and develop the capabilities needed to meet 21st Century threats."
The design-build contract was awarded in July 2007 to Harkins Builders of Marriottsville, who designed and constructed the new AFRC with architectural and engineering support from VOA Associates, STV Incorporated, and Nayyar and Nayyar. Design management was provided by the Louisville District of the Corps of Engineers, while the Baltimore District of the COE conducted the construction management.
"Our military deserves the very best in training, equipment, technology, facilities, BASOPS support, and everything that contributes to success on and off the battlefield, " Monk said. "Today marks yet another significant step along this path."
|Date Taken:
|Date Posted:
|03.15.2010 16:56
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text:
VTX-2337 and Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01666444
Recruitment Status : Active, not recruiting
First Posted : August 16, 2012
Last Update Posted : July 22, 2016
- Study Details
- Tabular View
- Results Submitted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to compare the overall survival of patients treated with VTX-2337 + pegylated liposomal doxorubicin (PLD) versus those treated with PLD alone in women with recurrent or persistent, epithelial ovarian, fallopian tube or primary peritoneal cancer.
VTX-2337, a small molecule agonist of Toll-like Receptor 8 (TLR8), activates multiple components of the innate immune system and is being developed as a novel therapeutic agent for use in oncology. Experimental data obtained in an animal model of ovarian cancer supports the combination of VTX-2337 with PLD. In this model, the combination of VTX-2337 and PLD resulted in a significant reduction in tumor growth compared to either agent alone and an increase in the number of T lymphocytes infiltrating the tumor. The combination of PLD and VTX-2337 has been tested in a small number of women with ovarian cancer in a Phase 1b study and appears to be generally well-tolerated.
|Condition or disease
|Epithelial Ovarian Cancer Fallopian Tube Cancer Primary Peritoneal Cancer
|Drug: pegylated liposomal doxorubicin (PLD) Drug: VTX-2337 Drug: Placebo
|Phase 2
Primary Objectives:
- To compare the overall survival (OS) of patients treated with VTX-2337 + PLD versus those treated with PLD alone in women with recurrent or persistent, epithelial ovarian, fallopian tube or primary peritoneal cancer.
- To compare the progression-free survival (PFS) between the two treatment groups using Immune-Related Response Evaluation Criteria in Solid Tumors (irRECIST).
Secondary Objectives:
- To compare the progression-free survival (PFS) between the two treatment groups using Response Evaluation Criteria In Solid Tumors (RECIST 1.1).
- To compare the nature, frequency and severity of drug-related adverse events (AEs) between the two treatment groups.
Exploratory Objectives:
- To compare the best overall response rate (ORR) and duration of response (based on the probability of being in response function [PBRF]) between the two treatment groups using irRECIST and RECIST 1.1.
- To compare the disease control rate (DCR) between the two treatment groups using irRECIST and RECIST 1.1.
- To assess the impact of immune status and response on the clinical effects (OS, PFS, DCR, ORR, PBRF, AEs) of study treatment.
- To assess the effect of TLR8 polymorphisms and BRCA1/BRCA2 mutations on the clinical effects (OS, PFS, DCR, ORR, PBRF, AEs) of study treatment.
- To assess the effect of immune cell subsets, as measured by immunohistochemistry and micro RNA in primary tumor tissue (e.g. immune score), on the clinical effects (OS, PFS, DCR, ORR, PBRF, AEs) of study treatment.
- To assess whether the presence of autoantibodies to tumor-derived proteins are predictive of the clinical effects (OS, PFS, DCR, ORR, PBRF, AEs) of study treatment.
This is Phase 2 multicenter clinical study to evaluate the efficacy and safety of the combination of VTX-2337 + PLD compared to PLD + Placebo.
The dosing schedule will be the same for both treatment arms, and will be based on a 28-day cycle. The starting dose schedule is PLD on Day 1 plus VTX-2337 or placebo on Day 3, Day 10, and Day 17 for the first 4 cycles. Starting with cycle 5, the dose regimen will be PLD on Day 1 plus VTX-2337 or placebo on Day 3.
Blood samples are collected periodically during cycle 1 for pharmacodynamics, pharmacogenomics, and other research studies.
Patients will receive therapy until disease progression based on Immune-Related RECIST or until adverse effects prohibit further therapy. Following treatment completion, all patients will be followed with physical exams and histories every three months for the first two years, and then every six months for the next three years, and then
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|290 participants
|Intervention Model:
|Parallel Assignment
|Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
|Primary Purpose:
|Official Title:
|A Randomized, Double-Blind, Placebo-Controlled Phase II Study of VTX-2337 in Combination With Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer
|Study Start Date :
|October 2012
|Estimated Primary Completion Date :
|October 2016
|Estimated Study Completion Date :
|October 2016
Experimental: PLD 40 mg/m2 plus VTX-2337
The dosing schedule will be be based on a 28-day cycle. The starting dose schedule is PLD on Day 1 plus VTX-2337 on Day 3, Day 10, and Day 17 for the first 4 cycles. Starting with cycle 5, the dose regimen will be PLD on Day 1 plus VTX-2337 on Day 3 only, without additional doses of VTX-2337 on Days 10 and Day 17.
Drug: pegylated liposomal doxorubicin (PLD)
Other Names:Drug: VTX-2337
TLR8 Agonist
Active Comparator: PLD 40 mg/m2 plus placebo
The dosing schedule will be based on a 28-day cycle. The starting dose schedule is PLD on Day 1 plus placebo on Day 3, Day 10, and Day 17 for the first 4 cycles. Starting with cycle 5, the dose regimen will be PLD on Day 1 plus placebo on Day 3 only.
Drug: pegylated liposomal doxorubicin (PLD)
Other Names:Drug: Placebo
- Overall survival (OS) of patients treated with VTX-2337 + PLD versus those treated with PLD alone [ Time Frame: Approximately 15 months after the last patient is randomized. ]Overall Survival analysis will occur when 146 deaths have occurred.
- Progression-free survival (PFS) of patients treated with VTX-2337 + PLD versus those treated with PLD alone using Immune-Related Response Evaluation Criteria In Solid Tumors (irRECIST). [ Time Frame: Approximately 15 months after the last patient is randomized. ]Progression is assessed at Week 12 and at 8-week intervals thereafter.
- Frequency and severity of drug-related adverse events (AEs) of patients treated with VTX-2337 + PLD versus those treated with PLD alone. [ Time Frame: Up to 6 months after the last patient is randomized. ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients must have recurrent or persistent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.
- Patients with the following histologic cell types are eligible: serous adenocarcinoma, endometrioid adenocarcinoma, mucinous adenocarcinoma, undifferentiated carcinoma, clear cell adenocarcinoma, mixed epithelial adenocarcinoma, transitional cell carcinoma, malignant Brenner's tumor or adenocarcinoma not otherwise specified.
- Patient must have measurable disease as defined by RECIST 1.1.
Patients must have received treatment with a platinum-based chemotherapeutic regimen for management of primary disease containing carboplatin, cisplatin or another organoplatinum compound. This initial treatment may have included intraperitoneal therapy, consolidation, non-cytotoxic agents or extended therapy administered after surgical or non-surgical assessment.
Patients are allowed to receive, but are not required to receive, one additional cytotoxic regimen for management of recurrent or persistent disease.
Patients are allowed to have received, but are not required to have received, biologic/targeted therapy (e.g., bevacizumab and/or PARP inhibitor) as part of their primary treatment regimen or for management of recurrent or persistent disease.
- Patients must have platinum-resistant disease, defined as having a platinum-free interval (PFI) of < 12 months after first- or second-line platinum-based chemotherapy, or having disease progression while receiving second-line platinum-based chemotherapy.
Patients must have adequate bone marrow, renal, hepatic, and neurologic functions as defined by the following:
- Bone marrow function: absolute neutrophil count (ANC) ≥ 1,500/mm3. This ANC cannot have been induced or supported by granulocyte colony stimulating factors. Platelets ≥ 100,000/mm3. Hemoglobin ≥ 9 g/dL.
- Renal function: creatinine ≤ 1.5 x institutional upper limit normal (ULN).
- Hepatic function: bilirubin < 1.2 mg/dL, SGOT (AST) and SGPT (ALT) ≤ 3.0 x ULN and alkaline phosphatase ≤ 2.5 x ULN.
Patients must have recovered from effects of recent surgery, radiotherapy or chemotherapy:
- Patients should be free of active infection requiring parenteral antibiotics.
- Any hormonal therapy directed at the malignant tumor must be discontinued at least one week prior to registration. Continuation of hormone replacement therapy is permitted.
- Any other prior therapy directed at the malignant tumor, including chemotherapy, biologic/targeted agents and immunologic agents, must be discontinued at least three weeks prior to registration.
- Any prior radiation therapy must be completed at least four weeks prior to registration.
- Patients must have a GOG performance status of 0 or 1.
- Patients of childbearing potential must have a negative pregnancy test prior to the study entry and be practicing an effective form of contraception. If applicable, patients must discontinue breastfeeding prior to study entry.
- Patients must meet the entry requirements and undergo the baseline procedures.
- Patients must have signed an IRB-approved informed consent form and authorization permitting release of personal health information.
Exclusion Criteria:
- Patients who have had treatment with VTX-2337, doxorubicin, PLD, or any other anthracycline.
- Patients who have received an investigational agent < 30 days prior to registration.
- Patients who have received oral or parenteral corticosteroids < 2 weeks prior to registration or who require ongoing systemic immunosuppressive therapy for any reason.
- Patients with active autoimmune disease. "Active" refers to any condition currently requiring therapy. Examples of autoimmune disease include systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis.
- Patients with a history of other invasive malignancies, with the exception of non-melanoma skin cancer, are excluded if there is any evidence of the other malignancy being present within the last three years.
- Patients who have received prior radiotherapy OTHER THAN for the treatment of ovarian, fallopian tube or primary peritoneal cancer within the last three years are excluded.
- Patients who have received prior chemotherapy OTHER THAN for the treatment of ovarian, fallopian tube or primary peritoneal cancer within the last three years are excluded.
- Patients with history or evidence upon physical examination of CNS disease, including primary brain tumor, seizures not controlled with standard medical therapy, any brain metastases, or history of cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA) or subarachnoid hemorrhage within six months of the first date of treatment on this study.
- Patients with clinically significant cardiovascular disease.
- Patients who are pregnant or nursing.
- Patients under the age of 18.
- Patients with clinical symptoms or signs of gastrointestinal obstruction and/or who require parenteral hydration or nutrition.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01666444
Hide Study Locations
|United States, Arizona
|St. Joseph's Hospital and Medical Center
|Phoenix, Arizona, United States, 85013
|United States, Arkansas
|Winthrop P. Rockefeller Cancer Institute - University of Arkansas
|Little Rock, Arkansas, United States, 72205
|United States, California
|Providence Saint Joseph Medical Center
|Burbank, California, United States, 91505
|Kaiser Permanente Medical Center
|Hayward, California, United States, 94545
|Long Beach Memorial Medical Center
|Long Beach, California, United States, 90806
|Kaiser Permanente Medical Center
|Oakland, California, United States, 94611
|Kaiser Permanente Medical Center
|Roseville, California, United States, 95661
|Sutter Cancer Center
|Sacramento, California, United States, 95816
|Kaiser Permanente Medical Center
|Sacramento, California, United States, 95825
|Kaiser Permanente Medical Center
|San Francisco, California, United States, 94115
|Kaiser Permanente Medical Center
|San Jose, California, United States, 95119
|Kaiser Permanente Medical Center
|Santa Clara, California, United States, 95051
|Kaiser Permanente Medical Center
|South San Francisco, California, United States, 94080
|Stanford University School of Medicine
|Stanford, California, United States, 94305
|Kaiser Permanente Medical Center
|Vallejo, California, United States, 94586
|Kaiser Permanente Medical Center
|Walnut Creek, California, United States, 94596
|United States, Colorado
|University of Colorado Cancer Center
|Aurora, Colorado, United States, 80045
|United States, Connecticut
|Hartford Hospital
|Hartford, Connecticut, United States, 06102
|St. Francis Hospital and Medical Center
|Hartford, Connecticut, United States, 06105
|The Hospital of Central Connecticut
|New Britain, Connecticut, United States, 06050
|Yale - New Haven Hospital
|New Haven, Connecticut, United States, 06520
|United States, Florida
|MD Anderson Cancer Center - Orlando
|Orlando, Florida, United States, 32806
|Women's Cancer Associates
|St. Petersburg, Florida, United States, 33701
|United States, Georgia
|Northside Hospital
|Atlanta, Georgia, United States, 30342
|Georgia Regents University
|Augusta, Georgia, United States, 30912
|Northeast Georgia Medical Center
|Gainesville, Georgia, United States, 30501
|Central Georgia Gynecologic Oncology
|Macon, Georgia, United States, 31201
|Memorial Health University Medical Center
|Savannah, Georgia, United States, 31404
|St. Joseph's - Candler Gynecologic Oncology
|Savannah, Georgia, United States, 31405
|United States, Hawaii
|Kapiolani Medical Center for Women and Children
|Honolulu, Hawaii, United States, 96826
|United States, Illinois
|Northwestern University - Robert H. Lurie Comprehensive Cancer Center
|Chicago, Illinois, United States, 60611
|Rush University Medical Center
|Chicago, Illinois, United States, 60612
|Sudarshan K. Sharma, MD, LTD
|Hinsdale, Illinois, United States, 60521
|Carle Cancer Center
|Urbana, Illinois, United States, 61801
|United States, Indiana
|Indiana University Medical Center
|Indianapolis, Indiana, United States, 46202
|St. Vincent Gynecologic Oncology
|Indianapolis, Indiana, United States, 46260
|United States, Iowa
|McFarland Clinic
|Ames, Iowa, United States, 50010
|University of Iowa Hospitals and Clinics
|Iowa City, Iowa, United States, 52242
|United States, Kansas
|University of Kansas Medical Center
|Westwood, Kansas, United States, 66205
|United States, Maine
|Maine Medical Partners Women's Health
|Scarborough, Maine, United States, 04074
|United States, Maryland
|University of Maryland Medical Center
|Baltimore, Maryland, United States, 21201
|Greater Baltimore Medical Center
|Baltimore, Maryland, United States, 21204
|Sinai Hospital of Baltimore
|Baltimore, Maryland, United States, 21215
|Johns Hopkins Medical Institution
|Baltimore, Maryland, United States, 21287
|United States, Massachusetts
|Lahey Hospital & Medical Center
|Burlington, Massachusetts, United States, 01805
|University of Massachusetts Memorial Healthcare
|Worcester, Massachusetts, United States, 01605
|United States, Michigan
|St. Joseph Mercy Hospital
|Ann Arbor, Michigan, United States, 48106
|Bronson Battle Creek
|Battle Creek, Michigan, United States, 49017
|Karmanos Cancer Institute - Wayne State University
|Detroit, Michigan, United States, 48201
|Henry Ford Health System
|Detroit, Michigan, United States, 48202
|Grand Rapids Clinical Oncology
|Grand Rapids, Michigan, United States, 49503
|Saint Mary's Health Care
|Grand Rapids, Michigan, United States, 49503
|Spectrum Health at Butterworth Campus
|Grand Rapids, Michigan, United States, 49503
|Gynecologic Oncology of West Michigan
|Grand Rapids, Michigan, United States, 49546
|West Michigan Cancer Center
|Kalamazoo, Michigan, United States, 49007
|Mercy Health Partners - Mercy Campus
|Muskegon, Michigan, United States, 49444
|Reed City Hospital - Spectrum Health
|Reed City, Michigan, United States, 49677
|Munson Medical Center
|Traverse City, Michigan, United States, 49684
|United States, Minnesota
|Minnesota Oncology Coon Rapids Clinic
|Coon Rapids, Minnesota, United States, 55433
|Fairview Southdale Hospital
|Edina, Minnesota, United States, 55435
|Abbott Northwestern Hospital
|Minneapolis, Minnesota, United States, 55404
|Metro Minnesota Clinical Oncology Program
|St. Louis Park, Minnesota, United States, 55416
|Park Nicollet Frauenshuh Cancer Center
|St. Louis Park, Minnesota, United States, 55426
|Minnesota Oncology Hematology - St. Paul Cancer Center
|St. Paul, Minnesota, United States, 55102
|Woodbury Clinic - CornerStone Medical Specialty Centre
|Woodbury, Minnesota, United States, 55125
|United States, Mississippi
|St. Dominic-Jackson Memorial Hospital
|Jackson, Mississippi, United States, 32916
|University of Mississippi Medical Center
|Jackson, Mississippi, United States, 39216
|United States, Missouri
|Ellis Fischel Cancer Center - University of Missouri
|Columbia, Missouri, United States, 65211
|United States, Nevada
|Women's Cancer Care Center of Nevada
|Las Vegas, Nevada, United States, 89169
|United States, New Hampshire
|Dartmouth-Hitchcock Medical Center
|Lebanon, New Hampshire, United States, 03756
|United States, New Jersey
|Cooper University Hospital
|Camden, New Jersey, United States, 08103
|Hackensack University Medical Center
|Hackensack, New Jersey, United States, 07601
|United States, New Mexico
|Southwest Gynecologic Oncology Associates
|Albuquerque, New Mexico, United States, 87016
|University of New Mexico Cancer Center
|Albuquerque, New Mexico, United States, 87106
|Memorial Medical Center
|Las Cruces, New Mexico, United States, 88011
|United States, New York
|Women's Cancer Care Associates
|Albany, New York, United States, 12208
|SUNY Downstate Medical Center
|Brooklyn, New York, United States, 11203
|Roswell Park Cancer Institute
|Buffalo, New York, United States, 14263
|Monter Cancer Center
|Lake Success, New York, United States, 11042
|North Shore University Hospital
|Manhasset, New York, United States, 11030
|Long Island Jewish Medical Center
|New Hyde Park, New York, United States, 11040
|NYU Langone Medical Center - Cancer Institute
|New York, New York, United States, 10016
|Columbia University Medical Center
|New York, New York, United States, 10032
|Memorial Sloan Kettering Cancer Center
|New York, New York, United States, 10065
|Gynecologic Oncology of Central New York - SUNY Upstate
|Syracuse, New York, United States, 13057
|United States, North Carolina
|Hope Women's Cancer Center
|Asheville, North Carolina, United States, 28806
|Alamance Regional Cancer Center
|Burlington, North Carolina, United States, 27215
|Carolinas Medical Center / Levine Cancer Institute
|Charlotte, North Carolina, United States, 28204
|Carolinas Medical Center - Northeast
|Concord, North Carolina, United States, 28025
|Wake Forest University Health Science
|Winston-Salem, North Carolina, United States, 27157
|United States, Ohio
|Summa Health System
|Akron, Ohio, United States, 44304
|University of Cincinnati
|Cincinnati, Ohio, United States, 45267
|University Hospitals of Cleveland
|Cleveland, Ohio, United States, 44106
|Fairview Hospital Moll Pavilion Cancer Center
|Cleveland, Ohio, United States, 44111
|Cleveland Clinic Foundation
|Cleveland, Ohio, United States, 44195
|Ohio State University Medical Center
|Columbus, Ohio, United States, 43210
|Women's Cancer Center at Kettering Medical Center
|Kettering, Ohio, United States, 45429
|Hillcrest Hospital - Cleveland Clinic
|Mayfield Heights, Ohio, United States, 44124
|Lake University Seidman Cancer Center
|Mentor, Ohio, United States, 44060
|United States, Oklahoma
|Peggy and Charles Stephenson Cancer Center
|Oklahoma City, Oklahoma, United States, 73104
|Tulsa Cancer Institute
|Tulsa, Oklahoma, United States, 74146
|United States, Pennsylvania
|Abington Memorial Hospital; Hanjani Institute for Gynecologic Oncology
|Abington, Pennsylvania, United States, 19001
|Geisinger Medical Center
|Danville, Pennsylvania, United States, 17822
|University of Pennsylvania Medical Center
|Philadelphia, Pennsylvania, United States, 19104
|Fox Chase Cancer Center
|Philadelphia, Pennsylvania, United States, 19111
|Hillman Cancer Center - University of Pittsburgh
|Pittsburgh, Pennsylvania, United States, 15213
|Western Pennsylvania Hospital
|Pittsburgh, Pennsylvania, United States, 15224
|Reading Hospital (McGlinn Family Regional Cancer Center)
|West Reading, Pennsylvania, United States, 19611
|United States, Rhode Island
|Women and Infants Hospital of Rhode Island
|Providence, Rhode Island, United States, 02905
|United States, South Carolina
|Medical University of South Carolina
|Charleston, South Carolina, United States, 29425
|Bon Secours St. Francis Hospital
|Greenville, South Carolina, United States, 29601
|Gibbs Cancer Center
|Spartanburg, South Carolina, United States, 29303
|United States, South Dakota
|Avera Cancer Institute
|Sioux Falls, South Dakota, United States, 57105
|United States, Texas
|UT Southwestern Medical Center
|Dallas, Texas, United States, 75390
|University of Texas Medical Branch
|Galveston, Texas, United States, 77555
|MD Anderson Cancer Center
|Houston, Texas, United States, 77030
|The Methodist Hospital
|Houston, Texas, United States, 77030
|United States, Utah
|Huntsman Cancer Institute, University of Utah
|Salt Lake City, Utah, United States, 84112
|United States, Virginia
|Mid Atlantic Pelvic Surgery Associates
|Annandale, Virginia, United States, 22003
|Virginia Gynecology Oncology
|Richmond, Virginia, United States, 23229
|Carilion Clinic Gynecological Oncology
|Roanoke, Virginia, United States, 24016
|United States, Washington
|Pacific Gynecology Specialists
|Seattle, Washington, United States, 98104
|Seattle Cancer Care Alliance
|Seattle, Washington, United States, 98109
|Northwest Hospital - UW Medicine
|Seattle, Washington, United States, 98133
|Women's Cancer Care of Seattle
|Seattle, Washington, United States, 98133
|University of Washington Medical Center
|Seattle, Washington, United States, 98195
|United States, Wisconsin
|Green Bay Oncology at St. Vincent's Hospital
|Green Bay, Wisconsin, United States, 54301
|St Vincent Hospital
|Green Bay, Wisconsin, United States, 54301
|Green Bay Oncology at St. Mary's Hospital
|Green Bay, Wisconsin, United States, 54303
|University of Wisconsin-Madison
|Madison, Wisconsin, United States, 53792
|Holy Family Memorial Medical Center
|Manitowoc, Wisconsin, United States, 54221
|Bay Area Medical Center
|Marinette, Wisconsin, United States, 54143
|Marshfield Clinic
|Marshfield, Wisconsin, United States, 54449
|Aurora St. Luke's Medical Center Gynecologic Oncology
|Milwaukee, Wisconsin, United States, 53215
|Medical College of Wisconsin
|Milwaukee, Wisconsin, United States, 53226
|Aspirus Regional Cancer Center
|Wausau, Wisconsin, United States, 54401
|Study Chair:
|Bradley J. Monk, MD
|St. Joseph's Hospital and Medical Center, Phoenix AZ
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|VentiRx Pharmaceuticals Inc.
|ClinicalTrials.gov Identifier:
|NCT01666444 History of Changes
|Other Study ID Numbers:
|First Posted:
|August 16, 2012 Key Record Dates
|Last Update Posted:
|July 22, 2016
|Last Verified:
|July 2016
Keywords provided by VentiRx Pharmaceuticals Inc.:
recurrent epithelial ovarian cancer
recurrent fallopian tube cancer
recurrent primary peritoneal cavity cancer
ovarian serous cystadenocarcinoma
ovarian endometrioid adenocarcinoma
ovarian mucinous cystadenocarcinoma
ovarian undifferentiated adenocarcinoma
ovarian clear cell cystadenocarcinoma
ovarian mixed epithelial carcinoma
Brenner tumor
Additional relevant MeSH terms:
Ovarian Neoplasms
Fallopian Tube Neoplasms
Peritoneal Neoplasms
Neoplasms, Glandular and Epithelial
Endocrine Gland Neoplasms
Neoplasms by Site
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Genital Neoplasms, Female
Urogenital Neoplasms
Endocrine System Diseases
Gonadal Disorders
Fallopian Tube Diseases
Abdominal Neoplasms
Digestive System Neoplasms
Digestive System Diseases
Peritoneal Diseases
Neoplasms by Histologic Type
Liposomal doxorubicin
Antibiotics, Antineoplastic
Antineoplastic Agents
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action


text:
Wednesday, January 30:
-Sacred Heart St. Patrick's in Eau Claire has canceled Lector and Eucharistic Minister In-Service tonight, and all religious education classes for all catholic parishes in Eau Claire have also been canceled
- Church at the Fair prayer meeting at Landmark Christian Church in Hallie has been canceled
- All youth and adult activities at Landmark Christian Church in Hallie have been canceled.
- All Eau Claire area catholic church religious education programs have been canceled.
-Calvary Baptist Church in Eau Claire has canceled all Wednesday evening activities
-First Church of Christ in Ladysmith has canceled Supper and Impact Program for Wednesday
-EAU CLAIRE, Wis. (Blugolds.com) – Due to deteriorating weather conditions across the state today, the UW-Eau Claire men's and women's basketball games vs. UW-Oshkosh have been postponed January 31. The men were scheduled to host UW-Oshkosh in Zorn Arena at 7 p.m. while the women were scheduled to play at UW-Oshkosh. Both games have been rescheduled for tomorrow (January 31) at 7 p.m.
-Faith Evangelical Free Church in Stanley has canceled Awana Club for Wednesday evening
-Western Technical College: Viroqua, Tomah and Mauston Regional Locations – Closing at 1:00 pm. All classes starting after 1:00 pm are canceled.
Sparta GED Center and Sparta Public Safety Training Facility – Closed at Noon. All afternoon and evening classes are canceled.
La Crosse, Black River Falls and Independence Locations – Closing at 3:30 p.m. All classes starting at 3:40 and later are canceled."
-All Eau Claire Wesleyan Church Actives are canceled Wednesday night


text:
Eighty yards. Fifty seconds. A couple laser-guided passes not many other NFL quarterbacks, if any, are capable of completing. An instantaneous decision for a QB sneak rather than clocking the ball resulting in an improbable game-winning touchdown vs. Dallas Sunday.
It was quarterback brilliance, the type which might be viewed as a coming of age for the Lions� Matthew Stafford, except he has done this many times before considering it is just his fifth NFL season, and he has started only 52 games because of injuries earlier in his career.
There was the Cleveland game as a rookie in �09. The rallies at Dallas, Minnesota and Oakland the playoff year in �11. Even in �12, a season which went horribly wrong in its totality, Stafford engineered come-from-behind wins over the Rams, the Eagles and the Seahawks before the collapse.
According to pro-football-reference.com, Stafford has produced 12 game-winning, fourth-quarter drives. That�s 23 percent of his NFL starts.
It�s a higher percentage than Peyton Manning (22), Tom Brady (21) and Joe Montana (20).
It�s an especially phenomenal stat when compared to Lions� quarterbacks of the past. Greg Landry was the last Lions� Pro Bowl quarterback. He had eight game-winning drives in 11 years in Detroit. Earl Morrall, who later was the NFL Player of the Year with the Colts, had seven in seven years with the Lions. Scott Mitchell and Charlie Batch had eight each, Gary Danielson nine in eight years. Erik Kramer and Rodney Peete had six apiece. Jon Kitna four.
Stafford still has many detractors. They�re loud on social media and persistent callers to sports talk radio, but the facts get in the way of the perception of his critics. He has reached 15,000 passing yards faster than any QB in NFL history. There will be a pointing to his overall record (22-31, 19-21 since �11), but Stafford joined the worst team in NFL history, which had been an unprecedented 0-16 the year before he was drafted first overall. By 2011, he quarterbacked the Lions to the playoffs. He played extraordinarily well down the stretch as the Lions made the postseason for the first time since 1999, and had a very good playoff game at New Orleans, despite the loss.
The idea Stafford is just a product of the greatness of wide receiver Calvin Johnson is preposterous. Johnson starred on the 2008 version of the Lions, catching passes for more than 1,331 yards and an NFL-leading 12 TDs. The Lions still went 0-16. A receiver, even one as genuinely great as Johnson, can only have so much bearing on a game. The quarterback has impact on many more offensive plays. Quarterback had been the missing piece for the Lions dating back to the 1950s, and the position�s importance is especially true in this day and age of the NFL, which is undeniably passing-oriented.
Stafford is much better because of Calvin Johnson. Any QB would be, but when Johnson was playing hurt earlier this season and not nearly as effective, Stafford still made plays.
Chicago was 3-0 when the Lions beat the Bears. A less-than-healthy Johnson caught passes for 44 yards. The Lions rallied to beat Cleveland, which had won its previous three games, on the road. Johnson, still ailing, had 25 receiving yards.
At Green Bay without Johnson, Stafford threw for 248 yards. The Lions lost, but they have never won at Green Bay with Johnson in the lineup, either.
Stafford rolled right and gunned the ball left down the left sideline in double-coverage right on target to Kris Durham for 40 yards on the game-winning drive Sunday. It was remindful of a throw for 43 yards Stafford made the previous week against Cincinnati to Kevin Ogletree. Durham and Ogletree are castoffs from other teams signed by the Lions out of necessity because of poor drafting at wide receiver and an off-the-field injury to veteran Nate Burleson. Rookie tight end Joseph Fauria has five touchdown receptions this season. He wasn�t drafted out of UCLA.
That�s nearly a third of the 16 TD passes Stafford threw the first half of this season. Oh, is Stafford�s success merely a product of the unstoppable Joseph Fauria?
In the Dallas game, Johnson, Ryan Broyles, Brandon Pettigrew and Reggie Bush all dropped passes. Johnson made a remarkable catch-and-run for 87 yards. He also won a jump ball between two defenders for another huge gain. Still, Stafford threw for 488 yards and would have approached 600 were it not for the drops.
At minimum Matthew Stafford is a very good NFL QB trending toward elite.
It�s strange, in a town which has been clamoring for such a player since Bobby Layne was traded to the Steelers in the 1950s, there is a splitting of hair suggesting the reasons are everything but Stafford himself.
This has been going on since the day Stafford was drafted.
So has the part of Stafford proving the skeptics wrong.


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Under-fire QPR boss Mark Hughes saw his side's winless start to the Barclays Premier League season extend to a 12th match as they slipped to a 3-1 defeat to Southampton.
Rickie Lambert bundled home his fifth of the season after 23 minutes to put the Saints ahead before Jason Puncheon doubled the advantage from the edge of the box at the end of the first half.
Junior Hoilett clawing one back four minutes into the second half but that was to be as good as it got for QPR as Southampton wrapped up victory when Anton Ferdinand deflected home Morgan Schneiderlin's late cross.
Copyright (c) PA Sport 2012, All Rights Reserved.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: https://www.givemesport.com/writeforgms


text: Hey everyone I have made a ported enclosure for my car 2 cubes tuned to 33 hz. It has 38.5 square inches of port area. I hit 131.9DB on the termlab using various test tones with the back seats down which is very sad. The sub is firing up and the port is firing back kind of like a crx style enclosure. I have two options, I could face the sub towards the rear or build another enclosure with the sub firing back towards the trunk tuned to 35hz but I will lose 5.5 square inches of port area. I don't know what you guys think? I know my car is a trunk car and not a hatchback like how my older car was so I understand I will not hit high numbers but I was expecting at least 140DB :(.


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text:
Mothership director David Rosenbaum teamed with Nike to create a launch spot for its new Flyknit technology and shoe collection. "Flyknit" sounds like it's knitted on the fly, and oh dear that's exactly what happens in this ad, a rather impressive post-feat starting with no feet, bare feet then flyknitting on feet. One is left with the impression that these shoes weigh nothing at all, and this jogging dude might want to consider socks.
Director David Rosenbaum of Digital Domain's advertising and entertainment production company Mothership was tapped by Nike to launch its revolutionary new Flyknit technology and shoe collection. Rosenbaum worked directly with NIke to conceive "Biomorph," the :51-second short to mark the debut of the new shoe technology. The spot premiered at the annual 2012 Nike Innovation Summit on February 21st and is also featured on Nike's website and YouTube channel, where it has generated almost 400,000 views. Sister company Digital Domain handled visual effects.
Nike approached Mothership with the mandate that the launch film should be performance-driven and an expression of how Flyknit shoes are knit seamlessly to form to a runner's foot like a second skin. Based on that brief, Rosenbaum developed a thirty-page story with images and a concept to convey both the unique attributes of the shoe and how those attributes impact the running experience.
"I was inspired by the concept of body schema—a term used across disciplines to describe the way that tools work with, and become extensions of the body. That really resonated with the way their Flyknit technology is designed—becoming an extension of the runner's foot, seamless and lightweight," said Rosenbaum. "From there the story of the progression of a barefoot runner's stride with threads that weave themselves around his foot to reveal the Flyknit shoe began to take shape."
The Flyknit shoes are the first to be manufactured entirely in-house at Nike headquarters in Portland, Oregon. Rosenbaum met with Nike engineers and watched the shoes get made on customized industrial knitting machines. Nike tackled a complex runner's challenge by creating a new material and method for making shoes; Rosenbaum worked with Digital Domain's artists to develop a visual expression for the innovative weaving process in which these shoes are made. In addition to developing the spot concept, every aspect of the execution from storyboards to shoot, edit and effects were done in-house at Mothership and Digital Domain; Rosenbaum also commissioned the music, a custom track composed by David Wittman at Elias Music.
A very limited run of Nike Flyknit shoes was issued to coincide with the debut, however the highly-anticipated collection will be available in a wider release this summer.
Client: Nike Andy Walker: Creative Director Jesse Canright: Executive Producer Barb Freeman: Production Manager The Bergeron: Producer Production by: Mothership David Rosenbaum: Director Ed Ulbrich: Chief Creative Officer, Digital Domain and President, Mothership Tanya Cohen: Executive Producer Scott Gemmell: Head of Production Tiffani Manabat: Producer Birthe Lauchengco: Production Supervisor Paul Cameron: Director of Photography Animation, Editorial & Visual Effects by: Digital Domain Ed Ulbrich: Chief Creative Officer, Digital Domain and President, Mothership Tanya Cohen: Executive Producer Scott Gemmell: Head of Production Aladino Debert: Visual Effects Supervisor David Liu: CG Supervisor Nicola Wiseman: Producer William Lemmon: Producer Rachel Mariscal: Digital Production Manager Colin Woods: Editor Richard Poulain: Storyboard Artist Brian Creasey: Generalist Casey Benn: Generalist Dave Carlson: Generalist Gideon Vandergrift: Generalist Kevin Culhane: Animator Adrian Dimond: Technical Director Michael Lori: Data Integration Ken Jones: FX Artist Eric Ebeling: FX Artist Jason Mortimer: FX Artist Rafael Colon: Lead Nuke Compositor Scott Hale: Nuke Compositor Sven Dreesbach: Nuke Compositor Jeff Heuser: Flame Artist Music by: Elias Arts Composer: David Wittman Creative Director: Dave Gold Executive Producer: Ann Haugen


text:
The lights are on
Last week during E3, Killer Instinct was one of the many emotional roller coasters that took gamers for a ride. When it was announced during Microsoft's press conference, the contingent that had been clamoring for the series return erupted in applause. Then, things got a little weird.
News started trickling out that Killer Instinct's return was marred by free-to-play tactics. Players will get one character (Jago) with the initial free download. Others are available as individual purchases.
What got lost is that the title will be optionally sold with a traditional price tag (whether that's equivalent to retail or what we now know as Xbox Live Arcade is unknown). This was cleared up when we interviewed Microsoft corporate vice president Phil Spencer at E3. Those that want the full experience and don't want to purchase piecemeal can do so.
It all sounds a bit like the traditional MOBA model pioneered by League of Legends and others. There are some key differences that make the implementation for Killer Instinct problematic.
The free character doesn't rotate. It's always Jago from the moment you download the title into the foreseeable future. Unless Microsoft enables some sort of character demo, you'll have to buy blind.
This is also challenging because of the genre. Fighting game aficionados have explained to me the importance of experimentation before settling on a primary character (a "main"). On the surface, Killer Instinct doesn't encourage that kind of testing opportunity.
Microsoft has used this model before. 2011's Crimson Alliance, an action RPG with classes that fit traditional and expected roles (tank, caster, balance), offered a packaged deal or individual character purchases. In a title like that, it's easy to pair your play style with one of the few options. Not so in a fighting game, especially one that hasn't been heard from since 1996.
Double Helix and Microsoft have some time to work out the kinks, but from what we currently know, the a la carte option doesn't seem like the way to go.


text:
Bucs drop fourth straight game
Trying to end its current skid, the CVCC men's basketball team lost the lead late against Spartanburg Methodist, and eventually, lost the game in close fashion, 68-65.
The Bucs loss is their fourth in a row.
CVCC trailed at 36-32 at halftime, but a great offensive effort in the early stages of the quarter allowed them to pull back into the contest.
With 7:00 remaining in the game, free throws by Terrence Polk gave the Bucs (3-5) their first lead of the half, 55-54.
That CVCC lead grew to as many as four, but it quickly whittled down thanks to a persistent rebounding effort by the Pioneers.
Spartanburg Methodist regained the lead with just under a minute remaining with a free throw by David Lighty.
With a chance to tie or take the lead, a long three-point attempt by CVCC failed. The Bucs were forced to foul, which grew the Pioneer lead to 68-65, and a last-second heave by CVCC came up empty.
The Bucs return the court on Saturday, where they travel to face Louisburg College at 3 p.m. CVCC's next home game is next Friday at 7 p.m. against Wytheville Community College.


text:
Story highlights
- Twin explosions strike a market in the city of Jos
- "Terrorists usually want to cause fear and trepidation," says one official
- Another official warns the death toll could go higher
At least 118 people were killed Tuesday in twin blasts at a market in the central Nigerian city of Jos, an official said, warning the toll could climb.
The explosions, which targeted Terminus market, went off some 20 to 30 minutes apart, setting fire to the entire venue.
"The death toll stands at 118. This is the number of victims recovered from the scene of the explosions, but we are still searching through the smoldering debris for more bodies," said Mohammed Abdulsalam, coordinator for the National Emergency Management Agency in the city.
"The figure may rise when the search is over," Abdulsalam said.
A journalist on the scene of the first explosion called it "massive." People were screaming and running, some covered in blood. Some had to be carried away, the journalist said.
An ambulance driver who asked not to be identified said he saw at least 15 bodies and about 30 injured.
Plateau State Commissioner Chris Olakpe described the blasts as "terrorist activities," but refused to speculate on who might be responsible.
He said the first blast was a suicide car bomb, while the second was caused by an improvised explosive device in a separate car.
Olakpe said 46 people were killed in the blasts and that 45 were injured, disputing the higher death toll provided by Abdulsalam.
It is not uncommon for authorities to report conflicting death tolls in the immediate aftermath of attacks.
"Terrorists usually want to cause fear and trepidation," said Olakpe. "By tomorrow, we will get on top of the matter."
In a statement, President Goodluck Jonathan condemned the bombings as a "tragic assault on human freedom" and described those behind them as "cruel and evil."
"President Jonathan assures all Nigerians that government remains fully committed to winning the war against terror, and this administration will not be cowed by the atrocities of enemies of human progress and civilization," the statement said, adding that Nigeria was committed to implementing anti-terrorism measures and resolutions put forth at a recent summit in Paris.
When CNN tried to speak with a nurse at a local hospital by phone, she was unable to hear because of victims' cries and screams.
CNN had previously reported three blasts at two markets -- Terminus and Abuja. Terminus market is also known as the New Abuja market. A possible third blast may have been a gas canister ignited by the first bomb.
Late Sunday, a bomb in the northern Nigerian city of Kano killed at least four people, according to local police.
The blast occurred at a busy intersection in a predominantly Christian area of the city and left several cars burning, Kano police spokesman Rabilu Ringim said. It was not immediately clear who was responsible for the attack, the spokesman said.
Terrorism in Nigeria has been in the spotlight recently since more than 200 schoolgirls were kidnapped by the militant group Boko Haram.
The terror group abducted 276 girls on April 14 from a boarding school in Chibok in northeastern Nigeria. Dozens escaped, but more than 200 girls are still missing.
In his statement Tuesday, Jonathan reaffirmed his government's commitment to take "every necessary measure" to find the girls and cooperate with other countries in the region to combat the "Boko Haram menace."
The president also said Nigeria was determined to ensure safety and security in schools in Borno state and other parts of the country and to rebuild the school in Chibok.
The government will collaborate with U.N. education envoy, former UK Prime Minister Gordon Brown, to launch a safety program called the "Safe Schools Initiative," said presidential spokesman Reuben Abati.


text:
Of the three dudes listed above,
I'd go in the following order:
Third place: Jason Alexander (good for a one-nighter);
Second place: Kevin James (good for a summer-long relationship);
First place: Richard Karn (DEFINATELY would spend the rest of my days with him).
***As a teen, I always wanted to punch Ted "the toolman" Taylor in the face
for always picking on Al ***
By the way, how could you have forgotten James Belushi??? (According to Jim)
Thar y'all go!


text:
|Hey Mom! Learn more about the Gerber Life Insurance Grow-Up Plan!
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Join Date: Feb 2013
Posts: 19
Cleaning diapers
I am new to cloth, I don't have any diapers yet but am going to try prefolds and pockets. I am going to get a diaper sprayer and one of those potty pails, and a wet bag . I am not sure though on a few things on how to clean the diapers. First, do I spray both pee and poop diapers? Do they need to be sprayed soon after being soiled or later like that night, or even on wash day? I am planning on washing every two to three days. The other thing is, if I do spray off the diapers before washing, do I just put them in the wet bag or do they need to be wrung out/ dried before putting in bag? I am concerned about these wet diapers sitting for couple days getting moldy. We live in a humid climate and I even have to make sure used towels are completely dry before putting in clothes basket bc I have found mold in fibers after them sitting for five days. Thanks for feed back, I am really excited to get started and want to be successful!
Registered Users
Re: Cleaning diapers
I prefer to spray poo dipes when they happen because my toddler has nasty poos & the longer they sit, the longer it takes me to get them sprayed clean. Some people prefer to wait & do all the poos at one time (especially if they have someone not too cd savvy watching LO during the day). I let ours hang on the side of the toilet to drip (only if kiddy safe though). I keep a poo wetbag in the bathroom & the poo dipes go in that bag & then I have an additional smaller bag for the PUL covers. We trifold so we lose every cover to poo. I do a pre-soak with my diapers before every load & I don't soak PUL in my Bac Out soak. This is why I have a separate wetbag for just covers. It's not necessary. It's more of a convenience thing. I don't spray pee dipes. They drop right into the big basket in the nursery. Some people spray night dipes because of the heavy pee saturation & ammonia that begins to develop, but I never did. We live in a very hot environment, but I keep the house cool. I only do laundry once a week now that I'm pregnant, working full time, & exhausted, but I've always had a pretty good laundry system so I've never had issues.
ds (12/99), 4 mcs, LO (May 2010), Newb (April 2013), 5th mc
Registered Users
Re: Cleaning diapers
You only have to spray formula poo or poo once baby starts solids. Otherwise Breastfed poo is water soluble and you can just put in wet pail. Some people find its a good idea to rinse all the diapers but I wouldn't start there.
Doesn't matter when you spray but generally its easier around when you change it.
if you live in a humid area you probably want to wash every other day since you probably wouldn't want to dry out each diaper.
BTW you might just want to try using a sprayer before bothering with a potty pail -- see if you need it first. Seems like something that would take up alot of room for little gain.
Mom to LO#1 born 1/7/2010 (Cloth diapered since day 1; Part-time EC since 9 months; Daytime PL since 29 months; Nightime PL at 5.5 years) & LO#2 born 12/1/2013 (First diaper was cloth! Part-time EC since 12 months & Daytime PL at 26 months) Checkout my absorbency tests. Thoughts on how long a cloth diaper REALLY lasts. Thoughts on Yeast , here, here, here & here. How to Wash Wool & Sanitize Wool. Everything must go! Nighttime Trainers
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Schultz Collection
David Hall: The 1938-S Oregon is fairly easy to obtain in even the highest grades. Of the three 1938 Oregons, the 1938-D is the most common in Superb Gem condition, followed by the 1938-S and then the 1938, but all three come super nice and are not rare at all in spectacular condition. Nearly the entire mintage was saved at the time of issue so circulated examples are extremely rare. The average grade of this issue is MS63 to MS67. The srike is always bold and marks are hardly ever a problem. The luster is satiny.
© 1999-2018 Collectors Universe NASDAQ: CLCT


text:
If former US senator Scott Brown decides to run against US Representative Ed Markey in the special election for Senate, the two would be locked in a statistical tie, a new poll finds.
The Republican Brown would get 48 percent of the vote, while Markey, a Democrat, would get 45 percent of the vote, if the election were held today, according to the poll released by Public Policy Polling. But the gap between the two fell within the survey's margin of error, plus or minus 3.6 percentage points.
Brown has not yet announced whether he will run against the veteran Congressman.
A surprising group of people did not want him to run, according to the poll: many Republican voters.
The poll found that 48 percent of Republican voters preferred that Brown run for governor in 2014, compared with 38 percent who thought he should run in the June special election for the seat left vacant by the departure of John F. Kerry to become secretary of state.
The pollsters also said Brown would start out with a substantial lead against possible Democratic gubernatorial candidates Steve Grossman, Carmen Ortiz, and Donald Berwick.
"Scott Brown has a tough choice to make," said Dean Debnam, president of the polling company. "He could make another Senate run with a 50/50 chance of victory, or choose a Gubernatorial race that might give him better odds."
US Representative Stephen Lynch is expected to announce Thursday that he will vie with Markey for the Democratic nomination for the Senate seat.
But the poll had bad news for Lynch, saying that Markey would garner 52 percent of the votes in a primary, compared with 19 percent. The margin of error for the Democratic results was plus or minus 4.9 percentage points.
The poll surveyed 763 voters and 404 Democratic primary voters Tuesday and today.