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Noriaki Shimokawa*
Department of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma, Japan
Received Date: October 22, 2012; Accepted Date: October 23, 2012; Published Date: October 25, 2012
Citation: Shimokawa N (2012) CIN85 is a Key Mediator in the Regulation of Behavior and Metabolism. Endocrinol Metab Synd 1:e114. doi: 10.4172/2161-1017.1000e114
Copyright: © 2012 Shimokawa N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Endocrinology & Metabolic Syndrome
Adaptor proteins are non-catalytic polypeptides that contain one or more domains that are capable of binding to other proteins or nonprotein ligands [1]. These molecules are essential for intracellular signal transduction involved in the regulation of endocrine action, metabolic activity, neuronal function, and cell growth. Recently, there has been growing evidence that adaptor proteins play critical roles in behavioral control and metabolic regulation. Glutamate receptor interacting protein 1 (GRIP1) regulates social behavior and modulates the autistic phenotype [2]. Maiya et al. [3] reported that a Lin11, Isl-1 and Mec-3 (LIM) adaptor protein, LIM domain only protein 4 (LMO4), regulates fear learning. The G protein-coupled receptor kinase-interacting protein-1 (GIT1) deficiency in mice causes psychostimulant-responsive attention deficit hyperactivity disorder (ADHD)-like phenotypes [4]. On the other hand, the hepatic tumor necrosis factor receptor-associated factor 2 (TRAF2) autonomously promotes hepatic gluconeogenesis by enhancing the hyperglycemic response to glucagon and other factors that increase cyclic adenosine monophosphate (cAMP) level, thus contributing to hyperglycemia in obesity [5]. In the present editorial, I briefly review a novel function of the adaptor/scaffold protein Cbl-interacting protein of 85 kDa (CIN85) in the regulation of behavior and metabolism.
CIN85 was independently identified as CIN85 [6], regulator of ubiquitous kinase (Ruk) [7], SH3 domain-containing gene expressed in tumorigenic astrocytes (SETA) [8] and SH3 domain kinase binding protein 1 (SH3KBP1) [9]. These genes were isolated from either human (CIN85), rat (Ruk and SETA) or mouse (SH3KBP1) sources and show between 92% and 97% sequence identities, suggesting that they represent homologues of one gene. The CIN85 gene is localized on the distal arm of the X chromosome (Xp22.1-p21.3) and its length is approximately 353.7 kb in humans (http://www.ncbi.nlm.nih.gov/sites/entrez?db= geneandcmd=retrieveanddopt=full_reportandlist_uids=30011). The main 3.2 kb CIN85 mRNA is expressed in all adult and newborn tissues [6,7]. Owing to alternative splicing and the use of different promoters, multiple CIN85 mRNA signals have been detected, which showed a more restricted pattern of expression [7]. CIN85 is composed of three N-terminal SH3 domains, followed by a centrally located proline-rich region and a C-terminal coiled coil domain [10]. Initially, CIN85 was identified as a negative regulator of epidermal growth factor receptor (EGFR) signaling and phosphoinositide 3-kinase (PI 3-kinase) signaling pathways via its interaction with c-Cbl [6,7]. Then, CIN85 was identified as a central adaptor molecule involved in the recruitment of the endocytic machinery required for the internalization of various cell surface receptors, including receptor tyrosine kinases such as EGFR [11,12], hepatocyte growth factor receptor (HGFR, Met) [13], and vascular endothelial growth factor receptor (VEGFR) [14], and also immunoglobulin IgE receptors in mast cells [15]. Recently, it has been reported that CIN85 is involved in the regulation of the immune system and cytokinesis. Using B cell-specific CIN85 knockout mice, Kometani et al. [16] found that CIN85 links the B cell receptor to IκB kinase-β/nuclear factor-kappa B (IKK-β/NFκB) activation, thereby contributing to T cell-independent immune responses. Haglund et al. [17] reported that Cindr, a Drosophila CD2AP/CIN85 ortholog, interacts with Anillin and that depletion of either Cindr or Anillin gives rise to binucleate cells and fewer intercellular bridges in vivo, therefore, Cindr is involved in complete and incomplete cytokinesis in Drosophila. In the future, as these reports, a novel function of CIN85 might be identified since CIN85 is expressed ubiquitously.
Recently, we have found a novel function of CIN85 in the regulation of the signaling of behavior and metabolism [18]. In the mouse brain, both of the major isoforms expressed, CIN85-xl and CIN85-l, were found to be abundant in most brain regions examined [18,19]. Interestingly, CIN85-xl is expressed only in the central nervous system (CNS). Furthermore, CIN85 colocalizes with postsynaptic density protein 95 (PSD-95) at postsynaptic sites in the somatodendritic compartment, in which it frequently clustered in dendritic shafts, as well as within dendritic spines [18]. Dendritic spines are small protrusions extending from the surface of dendrites, which are believed to be the main sites of excitatory synapses and are thus vital centers for synaptic transmission in the brain [20]. To investigate the function of CIN85 in the CNS, we generated mice deficient in the two major CIN85 isoforms expressed in the brain (CIN85-xl and CIN85-l) [18]. By homologous recombination, we deleted exon 2 of the CIN85 genomic locus (CIN85Δex2). As expected, all CIN85 protein variants encoded by transcripts initiated from promoter #1 (CIN85-xl, CIN85-l, and the shorter CIN85-ΔCP) were abolished in CIN85Δex2 mice.
CIN85Δex2 mice are viable and fertile, and display no obvious abnormalities in appearance. We subjected the CIN85Δex2 mice to extensive analyses of a broad range of parameters in accordance with the physiological screens defined by the German Mouse Clinic (http://www.mouseclinic.de/). Among the parameters tested, the mice showed a clear knockout-specific phenotype in behavior and energy metabolism. When subjected to the modified hole-board test [21], which assays spontaneous behavior such as forward and vertical locomotor activity, speed of movement, and exploratory behavior in a novel environment, the CIN85Δex2 mice showed significantly increased activities, as compared with the wild type. Specifically, the CIN85Δex2 mice exhibited increased forward locomotor activity, as manifested by increases in total distance travelled, number of line crossings, mean and maximum velocities, as well as turning frequency. In addition, CIN85Δex2 mice showed enhanced exploratory behavior, namely, entering the board more frequently and exploring a larger number of holes on the board than the wild-type mice.
Interestingly, the CIN85Δex2 mice display abnormally high levels of dopamine and D2 dopamine receptors (D2DRs) in the striatum, an important center for the coordination of animal behavior. Importantly, CIN85 localizes to the postsynaptic compartment of striatal neurons, in which it co-clusters with D2DRs. Moreover, it interacts with endocytic regulators such as dynamin and endophilins in the striatum. In neurons of the wild-type mice, CIN85 resides postsynaptically and associates with endocytic regulators, such as dynamin and endophilins, and it clearly has a crucial function in stabilizing endophilin binding to D2DRs in the striatum. The internalization of D2DRs is caused by the coordination of these endocytic proteins. As a result, dopamine signals are attenuated, and then the appropriate locomotor activity is maintained (Figure 1). As a consequence, the absence of CIN85 gives rise to insufficient endocytic internalization of D2DRs owing to the defect of endophilin recruitment to the endocytic complex after dopamine stimulation, increasing striatal dopamine receptor levels, which can, at least in part, explain the enhanced locomotor and exploratory behavior we observe in the CIN85Δex2 mice (Figure 1). The resulting increase in the expression levels of surface-associated D2DRs in CIN85Δex2 mouse striatal neurons and the ensuing hyperactivity phenotype are in line with earlier findings, showing that activation of postsynaptic D2DRs results in increased locomotor activity and that D2DR knockout mice display reduced spontaneous movements [22,23].
Figure 1: Model for involvement of CIN85 in internalization of D2DR. CIN85 localizes to the postsynaptic compartment of striatal neurons where it coclusters with D2DRs. CIN85 interacts with endocytic regulators such as dynamin, β-arrestin, and endophilins in the striatum (left panel). The absence of striatal CIN85 causes insufficient complex formation of endophilins with D2DRs in the striatum and ultimately attenuates D2DR endocytosis in striatal neurons in response to dopamine stimulation. The defect of D2DR endocytosis induces hyperactivity (right panel) [18].
When comparing CIN85Δex2 mice with wild-type animals, we found that the mice deficient in CIN85-xl and CIN85-l showed abnormalities in several metabolic parameters, including higher energy uptake level, higher lean mass, and lower fat content. Both male and female CIN85Δex2 mice showed a higher lean mass, as well as lower total and subcutaneous fat contents than their wild-type littermates. Female CIN85Δex2 mice also showed a significantly increased energy uptake level compared with their wild-type littermates. However, CIN85Δex2 mice did not show any significant alterations in insulin metabolism. The explanation for this phenotypical trait may be directly linked to the observed alterations in dopaminergic activity, given the previously reported involvement of D2DR-mediated signaling in the regulation of appetite, energy intake, and obesity. Multiple studies have shown correlations between striatal D2DR expression level and body composition and between low D2DR expression level and obesity [24]. A recent report has furthermore showed a strong link between certain D2DR allelic variations and obesity, suggesting that individuals with certain genotypes resulting in dopaminergic hypofunction are prone to obesity [25]. An enhanced dopaminergic signaling is, therefore, consistent with the slim appearance of CIN85Δex2 mice.
The involvement of dopaminergic signaling in the regulation of movement, emotion, reward feelings, and obesity is well established [26,27]. In agreement with this idea, aberrations in dopaminergic pathways have been strongly linked to various neurological or metabolic disorders, including Parkinson's disease, schizophrenia, ADHD, Huntington's disease, and obesity [26-28]. The molecular defects underlying these pathologies have not been fully characterized, but may include alterations in the expression levels of dopamine ligands and/or receptors, as well as defects in downstream signaling events [29,30].
CIN85 is a novel regulator of D2DR endocytosis, involved in controlling behavior as well as metabolism, and the use of CIN85Δex2 mice enables new developments in ADHD or obesity research.


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subset: commoncrawl


text:
Two Tibetan teenagers die in self-immolations
Two Tibetan teenagers have died after setting themselves on fire in Sichuan province, activists and US media said.
Lobsang Kalsang, an 18-year-old monk, and Damchoek, a 17-year-old former monk, set themselves on fire on Monday morning, London-based Free Tibet said.
It happened outside the Kirti Monastery in Aba county, where many of the self-immolations have taken place.
This brings the number of Tibetans who have set themselves on fire since 2009 to 51, the group added.
The BBC is unable to verify this figure. Foreign media are banned from the region, making reports hard to confirm. Chinese state media have confirmed some of the self-immolations but not all.
More than half of those who have set themselves on fire are believed to have died.
'No information'
The teenagers died on Monday evening after being taken to a hospital by Chinese authorities, Free Tibet said.
The young men were shouting slogans against Chinese rule and policies in Tibet as their bodies burned, Radio Free Asia (RFA) reported, citing witnesses.
"Witnesses saw them run about 20 steps with their bodies on fire, and then they fell to the ground," two monks based in India told RFA.
Former monk Damchoek has been identified as the brother of Tenzin Choedon, a teenage nun who died after setting herself on fire earlier this year, the reports said.
Lobsang Kalsang's roommate at the monastery was detained on Monday, both Free Tibet and RFA reported.
Aba county police said they had no information on the self-immolations, an Associated Press report said.
Kirti Monastery, which has been the focus of protests for more than a year, is surrounded by heavy security.
China's leaders blame the Dalai Lama, the Tibetans' exiled spiritual leader, for inciting the self-immolations and encouraging separatism.
He rejects this, and both activist groups and the Tibetan government-in-exile say the self-immolations are protests against tight Chinese control of the region and religious repression.


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So I have noticed a lot of talk on the Internet, magerzines and social media sites like twitter & instagram regarding "STROBING" Make up. It's talk that contouring is out and in is strobing. I've read that strobing is the brilliant new face sculpting hack for the lazy girls, but in my honest opinion , from what I've read it's basically alot of highlighting and NO contouring .
Instead of rounding up your best shading hues, dig out all your illuminating products. Strobing focuses exclusively on highlighter, applied where light would naturally hit your face (so, your cheekbones, brow bones, the center of your forehead, down your nose, and on your chin.) Dabbing on these soft, shimmery shades will make your complexion look radiant, fresh, and healthy while giving you an ethereal oomph that is sure to turn heads. The best part? Your skin won't feel suffocated by layers and layers of makeup in the Summer heat because you're only using one extra product.
IN my personal opinion I will still continue my normal highlight and contour routine , but I will give strobing a try during the summer time because it is a very glowy look .
I've attached a few pictures for examples of what strobing make up looks like
I will also do a strobing make up tutorial on my YouTube channel and I will post a blog with pictures of my look and more details along with the link to the video
Stay tuned 🙂
Kristen moodley


text:
Thiruvananthapuram: Two women were killed in separate rain-related incidents as heavy rains lashed several parts of Kerala, police said Thursday.
A woman died as earth caved in at nearby Balramapuram last evening while another woman died as an uprooted tree fell on her at Malappuram, they said.
Several long distance trains were delayed and some passenger trains cancelled as tracks were submerged in Kochi, officials said.
Power supply was disrupted in many places as trees and supporting poles were brought down by strong winds that accompanied the downpour, also causing extensive damage to crops and property, they said.
More than 250 houses were partly damaged.
The Meteorological Department here has forecast heavy rains and strong winds till tomorrow morning.
According to official figures, 20 persons have died and losses amounting to Rs 70 crore were reported across the state in summer showers since April. The crop destruction alone was around Rs 12 crore during the period.
As the heavy rain and wind continued, government opened a control room here to coordinate relief work. The District administration had been instructed to co-ordinate relief work.
A 24-hour helpline has been opened and people in low lying areas are being shifted to safer places, Ernakulam District Collector M G Rajamanikkam was quoted as saying in Kochi report.


text:
When personality differences cause ripples in the workplace, what are some of the thoughts that run through our heads?
- My boss just doesn't seem to get it!
My supervisor doesn't understand me!
I wish my co-worker would see things from my point of view!
Why won't my team leader take the time to really listen to my ideas!
There are many proven personality assessments being applied to the work environment. The information obtained from these assessments can offer individuals and employers some very valuable information for staff and organizational development. The process doesn't end with the results of an assessment. Rather the results can represent the first step toward enhanced communication and understanding between individuals and throughout an organization. If you have taken a personality assessment, such as the MBTI® (Myers Briggs Type Indicator), revisit your results and ask your human resources (HR) manager if additional feedback is available from a qualified assessment specialist. If you have not had the opportunity to take a personality assessment, ask your HR manager if this may be available, as a staff development tool. You can also be pro-active and visit a career professional, such as a counselor or coach, to complete the MBTI and obtain a qualified interpretation.
Personality assessments can provide valuable feedback on the various dimensions of your personality type, as well as insight into the other types of personality we encounter, as we interact with people each day. The MBTI® instrument, for example, defines 16 distinct personality types. When an individual receives an interpretation of their MBTI® results, they are introduced to some very powerful information concerning the characteristics, preferences, strengths and challenges associated with their personality type. One distinct version of the MBTI® is the Career Report, which is often used to guide individual's through a process of career exploration or career transition. The ultimate benefits to learning more about theories of personality and personality types may be the understanding and appreciation we gain for the people around us, as well as enhanced communication and relationships.


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- New
[BIOCHEM] ?-Arbutin Whitening Lotion (120ml)
Brand Owner of Arwin/Biochem Malaysia
Due to influences of the external environment, the skin is easily to be lack of water and have dryness and thick cuticles. Lotion is able to supplement a great amount of water and soften cuticles and moisturize the skin, helping maintain the health of cuticles.Two ingredients bring the effect of whitening and improve dark spots. Arbutin-restrain the formation of melanin Tranexamic acid-restrain the inflammatory cells.
Oleh kerana pengaruh persekitaran luaran, kulit mudah kekurangan air dan kekeringan dan kutikel menjadi tebal. Losyen mampu menambah sejumlah besar air dan melembutkan kutikel dan melembapkan kulit, membantu mengekalkan kesihatan kutikel. Dua bahan memberi kesan pemutihan dan mencerahkan bintik hitam. Arbutin-menahan pembentukan melanin. asid Tranexamic-menghalang radang sel.
[Main Ingredients/Bahan Utama]:
- Arbutin
- Tranexamic acid
- Hamamelis virginiana
- Scutellaria baricalensis
- Bread yeast
- Rice germ
- Acetylglucosamine
- Hyaluronic acid
- Cucumber
- Dipotassium glycyrrhizate
- Coffee extracts
- vitamin E
Dengan kesan membaiki bintik gelap 3 kali ganda, ia adalah losyen memutihkan kulit dari bintik-bintik gelap. Dengan ramuan terkini dan teknologi pemutihan, losyen pemutih ini membantu menghilangkan bintik gelap.
Daytime Care: Cleanse, Lotion, Biochemical nutrition, Mighty pen, Essence, Gel, Emulsion, Cream, Eye care, Sunscreen lotion, Make-up
Night Care: Make-up Remover Cleanse, Lotion, Biochemical nutrition, Mighty pen, Essence, Gel, Emulsion, Cream, Eye care.
Selepas membasuh muka, gunakan kapas atau tangan untuk menyapu losyen ke muka.
Penjagaan Harian: Cleanser, Losyen, Biochemical nutrition, Mighty Pen, Essence, Gel, Emulsi, Krim, Penjagaan Mata, Sunscreen Lotion, Solekan
Penjagaan Malam: Make-up Remover Cleanse, Lotion, Biochemical nutrition, Mighty pen, Essence, Gel, Emulsi, Krim, Penjagaan Mata.
Basic Information
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Please be reminded that using skin care products is not the same as having a medical or surgical treatment and the effects cannot be immediately observed, you may require long-term usage to see the improvements on your skin. Please stop using the product immediately if any red spots, swelling, itching, or skin irritation symptoms occurring. If you do experience any discomfort or allergic reaction after using the product, please consult a dermatologist or a doctor.
Since individual skin condition is different and the skin may react differently to the product, please apply a small quantity of the product behind the ear using a cotton bud to check if you are allergic to the product. If you feel any discomfort, you should immediately stop using the product and consult a doctor as soon as possible.
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We would only accept a return within 7 calendar days, which begins on the date you receive the item. This period is subject to restrictions and exclusions. 7 calendar days is measured from the date you receive the item to the post stamp date of your return parcel.
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We would not accept a product return when:
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Participant Page: Dizzy Dashers- Lifemark Amherst NS
Do you now anyone who suffers from dizziness, vertigo, vision impairment, hearing changes, cognitive or psychological changes, headaches? Sadly many people get undiagnosed due to lack of awareness.
I created this campaign because I would like to make a difference in the lives of vestibular patients worldwide!
"For over 25 years VEDA has been helping people with inner ear balance disorders learn how the vestibular system works and how to better understand and cope with their symptoms. We direct people to qualified professional services and provide a community of support so they don't feel like they are suffering alone." - See more at: http://vestibular.org


text:
Red Hat Bugzilla – Bug 848019
Kernel 3.5.x Fails To Boot / FC17 i686 with LVM
Last modified: 2012-10-03 02:20:46 EDT
Hi all,
I'm looking for assistance on where to report technical errors to the people that maintain the kernel.
Our Sony Vaio (VPCW216AH) has been running happily with LVM+EXT4 encryption on FC17 (32 bit), up until when linux kernel 3.5.0-2 was released.
We are currently upto date with all software, and v3.5.1-1.fc17.i686 still contains whatever error is causing our problem.
I have set auto-update completely off so that nothing else gets updated as our GRUB still has v3.4.6-2.fc17.i686 which still works fine, and I don't want that to go off the list. (It seems that it keeps the latest 3 kernels in place).
Who can I pass the relevant information to, to get this issue resolved.
They'll need to tell me what they need to know so that I can note in down and post/email it.
Basically, after it boots on 3.5.x, I get dropped to a "Welcome to emergency mode" prompt that asks for the root password and then to a shell (root) prompt.
I can get no further than this point, other than to be returned back to emergency mode.
There's a whole page load of info on the screen, but I don't know what is relevant for an investigator to see, and what's not.
I have another, newer, Sony Vaio which is booting v3.5.1-1.fc17 (but 64-bit) without issues. That machine is my work-horse and would be dramatic if I hit the same issues with that machine.
Can anyone point me in the right direction to get this critical error assessed and fixed?
Thanks in advance.
6 days passed already guys (and gals)...
When we're living on your 'bleeding edge' with the latest Fedora, it would be nice to get some feedback from bug reports that come under the 'fail to boot' due to a kernel update.
Sorry to be a grind.
After 10 days of waiting for a response, I wiped Fedora from the machine.
I wont be able to provide any informatio relating to this error.
This bug can be closed due to "no response".
Hi, I've the same issue with a Vaio FC16/64bit LVM+EXT4 encryption + preupgrade -> FC17
after the upgrade to FC17 the only kernel that boot is the 3.4.9-1-fc16
with the 3.5.2-1.fc17 and the 3.5.2-3.fc17 I've the same problem of Mr.Morris:
"Basically, after it boots on 3.5.x, I get dropped to a "Welcome to emergency mode" prompt that asks for the root password and then to a shell (root) prompt."
is possible to open the bug again? if is possible I'll prefer keep Fedora :)
Case re-opened for "sbobber". Good luck...
Hello, all!
I'm no longer a Fedora Linux user, since I switched to Archlinux sometime ago.
When I recently updated to kernel 3.5.x, on my first boot afterwards, I noticed I was also dropped to the systemd emergency console. What is more, if I remove the kernel command line argument quiet, systemd outputs just before mounting partitions that it cannot find root and swap partitions, which in my case are lvm logical volumes.
This is also a problem with some archlinux users and like in fedora, archlinux maintainers are unable to find a solution. I guess it's something which has to be fixed upstream (kernel or lvm or device mapper, i don't know...). Anyway, we in archlinux at least found a sucessful workaround at explained in this thread: https://bbs.archlinux.org/viewtopic.php?id=145714&p=1.
Add the folowing kernel command line argument: lvmwait=<lvm logical volume containin your root partition>. It will cause systemd to wait for 10 seconds to find the root volume.
Thank you for sharing this information.
very interesting, I will try, thanks
not work for me... Andy, what you have choose after Fedora?
I went back to Ubuntu. Chosen for stability. I took Ubuntu 12.04.1 LTS 32-bit for the wifes machine, and removed LVM from the equation too, just in case I hit the same issue again (as that machine is 2yrs older than my own). That being said, I have a 12.04.1 LTS 64-bit with full LVM encryption too, and no issues with that yet, although Ubuntu is still only running kernel 3.2.0-31, which isn't the version where the issue of this Bug relates to. I would hope that later kernels avoid this issue. I will, at all costs, be sure to avoid kernel 3.5.x with any LVM configuration just in case. Good luck.
Thanks for the suggestion, IMHO similar issue should be considered with more care by fedora team


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I got the quilt square removed and repaired from my stupidity. Now I am sewing it back into position on the quilt top.
I deicded to do it by hand. I just had a fit trying to decide the best way to maneuver that thing one 3 sides with the machine.
I would provide pics, but my battery is dead after our trip to the zoo a couple weeks ago. Maybe later.
Kim WW


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Once again .... its a Time thing. What gets done and what doesn't is often less of a choice than there just isn't any more minutes in the day!!! Do you ever run into that?
I have still been having some computer issues, but finally I think I have it figured out. It was one or both of my Photo programs... both have been banished from the computer.... for the time being, but it also means that editing pictures is now a bigger difficulty other than just not liking to do it, it also means that getting the pictures off the camera... is not possible! (I hate the way Windows handle photographs.)
I had a great time in Paducah and had my first opportunity to explore the town since moving to Kentucky. Paducah was supposed to be our move destination in Kentucky, but for some reason we couldn't find a house that would work for us. Oh well, we're close.
To fill the time between Fall Paducah and now... one of the local quilt guilds I belong to held our annual quilt show. I have a large job and a major responsibility on the show committee, so I was a busy bee...helping to set up/hang, work and then of course the take down/clean up, and I also manned the "I Have a Notion" booth. It wasn't a big space. It was the debut...
Yeah I know not too exciting and quite frankly I am looking forward to some quiet... time hanging around the house and not doing too much for a few days! HA!!! I'm going to keep dreaming.
More Later-Beth
Wednesday, October 4, 2017
Saturday, August 20, 2011
Point, Click, Quilt by Susan Brubaker Knapp Book Review & GIVEAWAY
This post has been edited to include a GIVEAWAY too. See the bottom for details :)
Admittedly I'm a book worm....and always have been. On any given day you will find no less than 6-8 books next to my bed and my chair...yep over 16 books....I'm insatiable. I LOVE BOOKS and I LOVE Susan Brubaker Knapp's latest book, Point, Click, Quilt.
Point, Click, Quilt was the first book I grabbed when I got to review the newest releases at Checker Distributors . I sat down and went through each page and gobbled it right up. If you have been a long time reader of the IHAN blog you already know how much I adore Susan's work. Believe it or not, I actually am fortunate enough to own one of her pieces...true :)
Look at how beautiful the Introduction page is to Point, Click, Quilt. The colors, stitching, and design just grab me....and that is just the beginning!
Susan shares how to take great photos for translation into an art quilt. Then she discusses design and composition before she moves on to the process of translating that photo into a great art quilt. After reading through her book I felt so much more confident and encouraged to create more art quilts of my own.
Did you know Susan also has DVD's....she does and I own both of them and have to say they are excellent...I highly recommend not only Point, Click, Quilt but also her DVD's - Master Machine Quilting and Master Machine Stitching.
If it were not for watching Susan's DVD's I don't think I would have ever even considered doing any thread painting. I thought that was for artists and clearly I'm not an artist (I know we are all creative...but honestly there is a real difference...trust me:)
This is "Red Eyed Tree Frog" my treasured Susan Brubaker Knapp (Blue Moon River) art quilt. It hangs in my kitchen and I absolutely love it. Go check out the Gallery at Blue Moon River...I promise you will really enjoy yourself. After your visit, I'm sure you will then completely understand why I highly recommend Point, Click, Quilt and Susan's DVDs.
Susan would love to giveaway an autographed copy of Point, Click Quilt to one very lucky IHAN blog reader. Isn't that fantastic? Make sure you leave a comment by Friday August 26, 2011 on this post and a winner will be drawn by random number generator. Best of luck to everyone....this is such a wonderful opportunity. THANK YOU Susan....this is terrific!!!
Thursday, February 17, 2011
IHAN CEO Goes To 2nd Grade
You know when you have "arrived" in mommy life when you are invited to give a talk at your child's school. A rare and savored moment when my son was so proud and pleased that it was "his" mommy talking to the entire 2nd grade class. Remember those days?
The kids are reading a book about a quilt so I was invited to come and talk about quilts today. I literally had 10 minutes to set up and 10 minutes to take down ....that is why the quilts are piled on the table.
I brought my current sewing machine and an older model (made before I was born...good to know I was not the oldest in the room :) I was thinking that children who come from families who don't sew might not have ever had the opportunity to see a sewing machine. There were several who raised their hands when I asked if this was the first time they had seen a sewing machine.
This is a mug rug (one of you will recognize it, it was a gift : ) that I sent around for kids to touch. The loved seeing such a "small quilt." I told them that people from all over the world swap these and fabric postcards too.
Nanny, Rick's Grandma, made this one and gave it to Rick and I for our wedding. She was 89 when she made this and it is hand appliqued. Could we all be so lucky? I sure hope so.....especially since I have projects to keep me busy until I'm 124 years old.
Then just 18 very short months later came Zach so he got a panel quilt....nursing one and two in diapers does not leave much time for piecing....know what I mean? It has a lot of hand embroidery and trapunto. (I made it while living in PA. Took it to Needles to show the girls and they said, "I love your trapunto." I said, "No that is not trapunto....I stuffed it." ROFL....I had no idea what trapunto even was...gotta love it.)
My only sampler quilt, "Many Hands." I thought it would be a good one to show all the variety of blocks.This was not even washed....it was taken straight off the sofa and put into a box and to the school....nice ay?
My signature quilt, "Crossroads." Given to me by MJ...she had all my PA friends sign it when I moved away. I cherish this piece. The kids liked that you could "write" on your quilts. Hope they don't go home and start autographing without permission....yikes.
These two are Diane's stained glass quilts. One of the kids said, "hey, they have that at my church." I need to Google "possession" again....because if I remember correctly.....possession is 9/10ths of the law isn't it?
This was the show stopper. All at once the room went, "ooooooohhhhhhhhh" and they smiled. I loved it...Thanks again Diane :)
Of course I took my, "Red Eyed Tree Frog" made by Susan Brubaker Knapp. It was a fun to see the kids eyes light up. Who could not love this tree frog? (my ears are plugged....and I'm humming loudly..I love frogs)
Amani Ya Juu. What fun being able to share a little of Africa with them today.
This was the insane part. When I was asked to come and talk about quilting I opened my big mouth and said I thought it would be cool if the kids could make a paper quilt. That was when it was just Aaron's class....then it was all of the 2nd graders....106 of them. So, it went from a paper quilt...to one block! We cut a zillion little pieces of scrapbook paper and put them into envelopes....a little block kit for each child. I showed them how they could use their pencil or marker to do the stitching. Note to self.....cutting a zillion little pieces of paper and counting them into kits takes a lot of time....next time....let them color in a quilt made on my EQ 7 Software!!!
Speaking of the Electric Quilt Company, I phoned them yesterday to see if they had ever presented to children before and did they have any recommendations. (Ya gotta go to the experts!!). They were so kind to e-mail me a little demo so I could show the kids that quilting has gone high tech and you can design quilts on the computer (fascinating to this middle aged mind). McSteamy came home for lunch and helped me pack up the van and off I went to the school. Guess what was not in the van? Yep....my laptop. He figured I did not need it (he had didn't know what I had planned). But....I'm ready to go next time :) Thank You Penny and everyone at EQ who helped me out! They rock....but IHAN blog readers already knew that, right? Right!
Well....sheepishly I share this pix......my new Tutto Machine on Wheels Bag....was delivered the day before yesterday but I did not open it because I've been sick. So this morning, I figure if I'm taking Martha to school....she needs her Mercedes to ride in....so I put baby Martha into her new Mercedes and off we went. Dang....I love this Tutto Machine on Wheels. Wanna know why I did not pick that pretty Red, Lime or Purple? Yes you do....don't act like you don't care....ok, so you don't care....just let me tell ya anyway....come on please...... because everything I have gets dirty...this won't show the dirt so quickly.
Thanks for listening :)
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Digital Currency Crypto Forum › Forums › All That Is Crypto › Types Of Written Essay – 407746
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Types Of Written Essay
The Four Major Types of Essays Time4Writing different types of essays has become critical to academic success. Essay writing is a common school assignment, a part of standardized tests, and a requirement on college applications. Often on tests, choosing the correct type of essay to write in response to a writing prompt is key to getting the question nbsp; 4 Types of Essay Writing Time4Writing This will help homeschool students and teachers learn more about essay writing with tips for each different kinds of essay students may be faced with. Four types of essay: expository, persuasive, analytical, argumentative , not tacked on at the end. Conclusion (related to the analysis and the argument) Your conclusion should explain the relation between the analyzed text and the presented argument. Tips for writing analytical essays: Be well organized. Plan what you want to nbsp; Purdue OWL: Essay Writing The essay is a commonly assigned form of writing that every student will encounter while in academia. Therefore, it is wise for the student to become capable and comfortable with this type of writing early on in her training. Essays can be a rewarding and challenging type of writing and are often assigned nbsp; General Classification of Main Essay Types: The Top 10 of essays. It will help you understand the main features of essay writing and composition. Date: Dec 15, 2017. What is an essay? Interestingly, but the majority of students gets confused or even stressed the very moment they are asked to come up with this piece of academic nbsp; Types of Essays Writig Guides and Topics – Essay Info . Essays can be a difficult business for a college student. There 39;s rules to follow for each different type of essay, and it can be complicated to keep them all in order. Take a look at these types of essays and remind yourself of what the rules are for each. 5-paragraph Essay middot; Admission Essay middot; Argumentative nbsp; Kinds of Essays – Writing Tips – TestDEN of essays there are to help an English learner improve their writing skills or as a review for a student taking the TOEFL test. Different varieties of essay, different kinds of writing will require different types of writing and sometimes a single essay will require more than one type of writing. Here 39;s a guide to some of the most common sorts of writing and ways of organizing essay nbsp; Types of Papers amp; Student Samples of Papers amp; Student Samples. Analysis Essays middot; Argumentative Essay middot; Persuasive/Persuade middot; Cause and Effect Essays middot; Comparison and Contrast Essays middot; Definition Essays middot; Narrative amp; Descriptive Essays middot; Division amp; Classification Essays nbsp; Essay Writing – 6 Common Types Analysis Essay Writing activities in almost all of their subjects. The initial step is usually to decide on what topic to discuss. But the next big decision that essay writers confront is what type of essay to employ. What technique works for the selected topic? What kind of writing style is suitable? What tone is efficient?
4 Types of Essays – Udemy Blog
An expository essay is a specific kind of essay that involves investigating an idea, evaluating the evidence, presenting the idea, and supporting the presentation with an argument. Expository essays are usually written through comparison and contrast, definition, example, and the analysis of cause and nbsp; Types of Essay Literary Devices of Essay. An essay is a short academic composition. The word essay is derived from a French word essai or essayer, which mean trail. In composition, however, an essay is a piece of non-fiction writing that talks or discusses a specific topic. Presently, essay is part of every degree program. Essay Examples – Examples on YourDictionary examples would vary according to the type of essay you wish to write. Four kinds of essays exist including: narration, description, exposition, and argument. The following is an example of a famous narrative written by John Updike, quot;Hub Fans Bid Kid Adieu quot;: quot;The afternoon grew so glowering that in the sixth inning nbsp; Writing Overview – Types of Academic Essays – Aims Community in an academic setting fall into one of four categories, or modes: exposition, narration, description, and persuasion. There are variations (or subcategories) of different essays that are written in each main mode, but each variation ultimately has the same overall purpose: Exposition: an essay that attempts nbsp; 3 Types of Essays Are Models for Professional Writing Forms of essay most commonly assigned in school the narrative essay, the persuasive essay, and the expository essay conveniently correspond to those writing forms most frequently published online and in print. Your experience with these prose forms is ideal preparation for writing for publication. Four Different Types of Writing Styles: Expository, Descriptive It is a subject-oriented writing style, in which authors focus on telling you about a given topic or subject without voicing their personal opinions. These types of essays or articles furnish you with relevant facts and figures but do not include their opinions. This is one of the most common types of writing. 5 Different Types of Essays Pen and The Pad In high school and college there are several types of essays that students face. These styles encompass writing skills that students need throughout life, excluding technical writing, and mastering the styles early allows students to focus their efforts on content rather than form. Each instructor will have nbsp; Essay – Wikipedia and styles of essay writing. These forms and styles are used by an array of authors, including university students and professional essayists. Types of essay writing – Custom-ESSAYS. org of essays on Custom-Essays. org. Types of essays RRU Library of assignments during your program, but four of the most common types of essays are described below. To receive similar information via a video, please view quot;Four types of academic writing quot; (4:31), which is a section of the quot;Introduction to Academic Writing quot; video (also nbsp; 14 Types of Hook sentences with examples Flashcards Quizlet topic. Example: quot;As a child I was deathly afraid of water, so naturally I joined the swim team. quot; Rhetorical question. A question that inspires curiosity, but that cannon be simply answered (but it should be addressed in your essay).
The difference between essays and other forms of writing – Scribbr
Barring the obvious answer (to get a degree), in answering this question we need first to ask, what distinguishes an essay from any other form of writing? Most people will have strong intuitions that newspaper articles, scientific reports, and short stories, for example, are not forms of essay, but it might be nbsp; Different Types of Essays Samples starting from Basic Essay of essay they have been assigned with. It seems to them that writing within essay type boundaries doesn 39;t allow them to think out the box, limits their potential. But writing a paper without any directions could be even more confusing than the class assignment you got. Do not think nbsp; Essay Types Help with different types of essay – UK Essays – Essays are written for different purposes and for different occasions so to help you further we have listed all the different essay types. Essay Structure – Harvard Writing Center – Harvard University an academic essay means fashioning a coherent set of ideas into an argument. Because essays are essentially linear they offer one idea at Although there are guidelines for constructing certain classic essay types (e. g. , comparative analysis), there are no set formula. Answering Questions: The Parts of an Essay. Essay Tips for Essay Types C English Essay Writing : C. by Owen Fourie. What is involved in each of these kinds of essays? (If you are a new reader of this blog, the introduction to this particular category will help you to understand how this post fits into the bigger picture. ) Cause-and-Effect. Examine a situation, a condition, or an idea to understand what caused it nbsp; How to Write a Good Hook for Your Essay – Bid4Papers So, the very first step in writing a strong essay hook is to do some planning. Consider the overall presentation of your work: What type of essay are you writing? What type of writing style and tone will you need to use? Who is your intended audience? What kind of structure do you need to establish? What Are The Different Types Of Essay Writing? – YouTube Time4writing time4writing writing resources types of essays url? Q webcache. General classification of main essay types the top 10essay writing 5th slideshar The Types of Imagery in Essay Writing Pen and The Pad Imagery has its root in the word image, but as an idea it encompasses so much more than just our visual senses. Imagery in writing is capable of communicating to all five of our senses. When placed in the appropriate order, words can evoke sensations like the heat of the sun on our bodies, the smell of nbsp; Write My Essay for Me Services by of Papers Can I Order? Thinking quot;I need someone to write an essay for me quot; is nice but lacking. Please clarify the type of essay you need: Critical Thinking; Coursework; Creative writing; Presentation; Research paper; Term paper; and more!
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Greenwich artists commanded a great deal of attention at this year's National Cowboy & Western Heritage Museum Prix De West Invitational Art Sale and Exhibition.
Curt Walter's walked away with the Nona Jean Hunsley Buyer's Choice Award for his stunning work, Enigmatic Long House. Chris Blossom, Steve Hanks, Dan Smith and Morgan Weistling sold-out their paintings at the show. Other members of the Greenwich Family of Artists in attendance included Dean Mitchell, Loren Entz, Carrie Ballantine and Greg Beecham.
Monday, June 13, 2011
Curt Walters Wins Prix De West Buyer's Choice
Posted by Scott Usher at 12:03 PM
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|Awesome mechanical structure
|It was moving fast.
Who do not love to rush their adrenalin to their brain?
Well, I don't.
The Berjaya Times Square is unique because it has a playground inside. The best part is, the playground even has a roller coaster high rise mechanical structure which keeping human adrenalin at the high high level.
I always wanted to play this thing when I was a child, but after a freaking adrenal high high level I got while riding roller coaster in Genting Highland, I sure did deleted this one from my play list wish ever. I hate heights because it gave me nausea. So long dear roller coaster.


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BANAL: Lacking in freshness, originality, or vigor-bored by his banal remarks. Synonyms: commonplace, hackneyed, prosaic, trite, stereotyped, vapid. Antonyms: racy, original, vivid.
BANEFUL (noun: BANE: poison; source of harm): Destructive, poisonous - a baneful effect, causing serious injury. Synonyms: deleterious, pernicious, virulent, noxious, toxic. Antonym: beneficent.
BANTER: Good-natured teasing or ridicule-The two wits I exchanged banter, to the amusement of the audience. Synonyms: raillery, chaff
BATON: A stick or staff - The conductor wielded his baton gracefully.
BELIE: To give a false idea of - His gracious manner belled his evil purpose. Synonym: misrepresent
BELLICOSE; Inclined to quarrel; warlike - His bellicose attitude often got John into fights. Synonyms: pugnacious, contentious, disputatious. Antonyms: pacific, conciliatory.
BELLIGERENT: Engaged in war - two belligerent nations warring fiercely.
BENEVOLENT: Kindly; charitable - like a benevolent monarch, bestowing many favors. Synonyms: benign, benignant, gracious, magnanimous. Antonyms: malevolent, malignant.
BEREAVE: To deprive or leave desolate by loss - a widow just bereaved of her husband.
BESMIRCH: To soil or dirty - besmirched his opponent's good name with vile epithets. Synonyms: stilly, defile, smirch, bespatter.
BIASED: Prejudiced - misled by a biased point of view. Synonyms: bigoted, arbitrary, partial, partisan. Antonyms: disinterested, equitable.
BIBLIOPHILE: A lover of books - The bibliophile fingered the old book fondly. Antonym: bibliophobe.
BIZARRE: Queer; unusual in appearance- bizarre clothes, outlandish in the extreme. Synonyms: odd, fantastic, grotesque, eccentric.
BLAND: Gentle; polite; agreeable - a bland diet, without irritating foods. Synonyms: mild, suave (affable or persuasive in manner), soothing, non-irritating. Antonyms: piquant, tart, racy, caustic, acrid, pungent.
BLANDISHMENT: A flattering speech or act - attracted people by his blandishments.
BLEMISH (verb): To scar or spoil - Bad associates blemished his character; (noun): A disfigurement, defect - a character without a blemish.
BLIGHT: To ruin or decay - the rotting wheat, blighted by incessant rain. Synonyms: wither, blast
BLITHE: Gay and light-hearted in spirit or mood - spread cheer with her blithe spirit. Synonyms: jocund, merry, joyous. Antonyms: dejected, forlorn, abject.
BOG: A swamp - sank into the spongy bog. Synonyms: morass, fen, quagmire, mire.
BOMBASTIC (noun: BOMBAST): High-sounding; pretentious in language - a bombastic speech, inflated with meaningless high-flown words. Synonyms: ranting, pompous, fustian.
BOORISH: Unrefined in speech or manners - exhibited the boorish manners of a backwoodsman. Synonyms: churlish, uncouth, uncultured, crass. Antonym: suave.
BUCOLIC: Pertaining to the country - a bucolic poem - the joys of the shepherd. Synonyms: pastoral, rustic, rural.
BUFFOON: A clown - acting like a buffoon, full of ludicrous tricks. Synonym: harlequin.
BULWARK: (1) An embankment used as a fortification - a lofty bulwark for defense. Synonym: rampart. 2) A person, idea, or object serving as a protection - acted as a bulwark in the fight against crime.
BUMPTIOUS: Obnoxiously conceited or self-assertive - a bumptious monitor, puffed up with his own importance. Synonyms: aggressive, arrogant, contumelious, overbearing.
Please leave a comment IF you like the entry. It's like visiting a place where there is a guest book by the front door. Before you exit, you sign it to leave a note about your experience of the place.I know that people are visiting by virtue of site meter, but almost no one leaves a comment.If you are in a hurry (and who isn't these days?), just leave a "thanks".Thanks


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Uranium: October 2010 World Uranium Resources Data: "Paladin should be celebrated for opening not one but two African mines, Langer Heinrich in Namibia and Kayelekera in Malawi. Paladin is meant to be increasing production from its African mines to 7.3 million pounds this year, more than double final year's effort. Yet a first-quarter report showed manufacture at 1.36 million pounds, but with sales and the received price both 20 per cent lower than they were in the earlier quarter"
'via Blog this'


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Sayaka, Eri, and Miki all gather up for a chat before sucking on each other's tits. The forth person comes in and lays down while the three girls experiment on him. They lick his nipples and find out that his cock gets really hard. Eri starts by grabbing it and puts it in her mouth, sucking it hard and deep before he sits up and fucks all three of them!
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One Month Update in Korea!
December 18, 2015
Happy Holidays!!! I can't believe I have been teaching and living (if you don't count the first week of training) in Korea for a whole MONTH! 🙂 I haven't really shared much about my classroom, students, or life in Korea in general, but I promise it's all been great! This past month, I've grown immensely as … More One Month Update in Korea!


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Trading with MetaTrader 4 allows you to plan and execute your orders fast and easy. The platform gives you the opportunity to trade currencies, CFDs, and commodities.
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Almost daily I head into life as if I didn't know better, as if history and experience have impressed nothing on me. Lalalala – oops. There I am, right in the middle of humans behaving very badly. Disappointing, betraying, insulting, wounding, being cruel frauds. And I'm not even judging. That's observation.
It's okay, though. It takes only a moment of enchantment and my best me is restored. I wonder if this is true for all people.
I hope so.


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NEW DELHI — Defense Secretary Donald H. Rumsfeld began a peace mission to India and Pakistan on Tuesday, aiming to build on an easing of tensions that had brought the nuclear-armed rivals to the brink of war over the disputed Himalayan region of Kashmir.
In Washington, President Bush said American efforts to lower the heat had made progress, but he cautioned that with 1 million troops in place along the India-Pakistan border, the risk of war had not passed. India did announce earlier that it was ordering warships back to port, and it has reopened its airspace to Pakistani flights.
"The situation is getting better, but so long as there's troops amassed and people are still hostile, there's always a threat something could happen," Bush said.
Rumsfeld said that although recent comments from the South Asian neighbors had been positive, intelligence data appeared to suggest that the situation on the ground had not improved as much as the public statements implied.


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Desk. Friday , February 09th , 2018 - 15:02:38 PM
Get a toothbrush and work some bleach into the stain. Try to be gentle, just gently rub the brush over the area of the white desk that has been stained. You just want to try to rub the bleach into the stain to take over the color. Put vinegar and some baking soda on the stain. This will produce a foaming action that is found in a lot of cleaners. The hope is that the foaming action will lift up some of the stain and all of your worries will go away.
The first step is to be aware of how you sit at your desk for long periods of time. Most people will slouch down into the chair, or they will lean forward onto the desk and hunch their shoulders. This posture can stretch out your spinal ligaments and strain the spine. To alleviate this problem, you should make sure you have adequate lumbar support from your chair, and align your lower back directly against the chair back. If you are unable to do this comfortably, invest in a lumbar support cushion so your lower back can rest directly onto the cushion. This will help insure that you sit up comfortably and don't slouch.
When setting up your workstation, the most important measurement will be the desired height of your computer desk. Once you have your desk configured properly, you then can adjust the computer desk chair to the height of your workstation. For example, your elbows should be at a 90-degree angle when you place your hands on your desk. If they are not, adjust your chair up or down until your elbows are the right angle. You also want to make sure you are allowing your gaze to easily fall into the middle of the computer screen. You may be unconsciously straining your neck if your gaze falls to high or to low.
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So I have a work trip to Hong Kong coming up and interested in recommendations both food and knife related.
Thanks in advance!
So I have a work trip to Hong Kong coming up and interested in recommendations both food and knife related.
Thanks in advance!
If you are interested in cleavers, you shd definitely check out Chan Chi Kee in Shanghai Street.
G/F.,, 316-318 Shanghai St, Yau Ma Tei, Hong Kong
Great suggestions and thanks. Any food spots or bar suggestions?
In terms of restaurants:
Yat Lok - Has a Michelin Star, but expect to sit in a very cramped space, next to strangers and be rushed out within 30 minutes, however the roast meats (especially the roast goose) are superb
Kwan Kee Claypot Rice - Traditional Cantonese claypot rice, expect a long queue, although there is another place nearby that sells the same thing (think it's called Four Seasons), also get an oyster pancake
Rainbow Seafood - Awesome Cantonese style seafood restaurant on Lamma Island
Ho Lee Fook - Modern Cantonese, get the wagyu short ribs
Lord Stow's Egg Tart at EXpresso, The Excelsior - Delicious Portuguese egg custard tarts
Mochi shop - There's an tiny unnamed mochi shop that does mango mochis at 311 Hennessy Rd
Tung Po - Classic, old school, busy, loud, manic, Hong Kong dai pai dong that specialises in seafood
Ming Court - Upscale Cantonese, (has two Michelin Stars) I had a good meal here back in 2013, expect to spend about £80 per head without drinks. I preferred it to the 2 Michelin starred Yan Toh Heen which I went to in 2015)
You'll probably come across the name 'Tin Ho Wan' if you do any research, personally I think the quality has dropped massively recently. Go somewhere else if you're looking for Dim Sum.
My list is only of Cantonese/Chinese places, there's loads of excellent western food and I've eaten very good sushi in Hong Kong too. I liked Sushi Hiro at 7/F, The Toy House, 100 Canton Road, Tsim Sha Tsui when I went to HK in 2013.
You're in for a treat if you like Asian food, Hong Kong is one of the best places in the world to eat, and also my personal favourite city in the world.
Bars, there are millions of western style bars. Definitely go to one on a rooftop to enjoy the view. I've been to Sugar and Ozone on the 118th floor of the Ritz Carlton (one of the tallest bars in the world).
Damn awesome suggestions. Much appreciated!
Hi Lim,
Food... I think there are many suggestions on the web :-) If you have any preferences do let me know.
For knives, beside Chan Chi Kee, you may want to check out
1. Chan Wah Kee at G/F, 278 Temple Street, Jordon, Kowloon
2. Syoukon Hamono at Room 1915, 19/F, Solo City, 505 Hennessy Road, Causeway Bay
See my post of earlier today about my return trip from Chiang Mai transferring through Shanghai. I've have transferred through Hong Kong a number of times with no problem but don't book a trip to Hong Kong that requires a transfer in Shanghai!!!!


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We have started re-introducing technology back into our lives. We are going to see how the week goes. I'm convinced Sammy is a college professor somewhere in his spare time, coaching people on manipulation and bargaining. He got us to agree to eating FOUR peas tonight (he despises vegetables) in order to get a few bites of dessert. After we agreed to the four peas, he looked at Dan and said, "Ok, four!" as he held up two fingers. Seriously!
Today Dan and I decided to each take a boy and have separate "date days" with our boys. It was a Sammy-Mama day and an Elijah-Daddy day. Sammy and I ran a few last-minute Christmas errands and then had lunch at his establishment of choice - Applebee's. During lunch, I learned that Sammy wants to be a "firefighter daddy" when he grows up. I explained that firefighters need to be strong and therefore eat their vegetables. Also that he will first need a wife if he wants to be a daddy. He told me that he wants to have FOUR boys and have a "pretty and nice" wife. :)
The boys are LOVING the Christmas season this year more than ever! It is so much fun. I got presents wrapped last night and they ooo-ed and aahhh-ed over the gifts that sat "under the tree" this morning. Ohhh dear...our tree. This year we got the prettiest, biggest, fullest tree we have ever had before. It is beautiful! About a week into having it as a part of our family, Dan and I started commenting on how much water this thing could drink! "I filled it up twice today!" "Me too!" A few days later our house had a unique scent. Our tree stand had a crack in the bottom, we found, and we had been pouring gallons and gallons of water straight into our carpet! GROSS! We got a new stand and all is well now for our pretty tree, minus the lingering wetness and smell. We have air fresheners, fans and towels all over our downstairs. So our presents aren't technically under our tree yet.
We are super excited about the next few days! When we said our bedtime prayers tonight, I was so happy to hear Sammy say, "I'm so happy for Jesus!" We try very hard to keep that at the forefront amidst this totally crazy time of year. It seems impossible sometimes, doesn't it?
I hope you all have a wonderful Christmas! Thank you so much for checking in!!


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Another Catholic Mom answered these five questions, and I thought I would, too. (By the way, head on over there because she'll be giving birth to her next baby sometime tomorrow, it seems. Be sure to congratulate her.)
Anyway on to the five questions.
1. Would you be willing to commit perjury in court for a close friend? What if your lie would save his life?
Oh, I am so terribly truthful. I have been pulled over for speeding once, and when the officer asked me, "Did you know you were doing 70 in a 60 MPH zone?" I answered, "Yes."
So I probably wouldn't commit perjury. And my husband knows that, so he'd better not get himself into any serious trouble!
2. Would you be willing to eat a bowl of live crickets for $40,000?
NO!!!! I cannot say that strongly enough. NO NO NO NO NO NO NEVER! Not for ANY amount of money.
To save the life of my children? Yes.
(Oh, I think I might have thrown up in my mouth a little there. Let's hope they are never kidnapped by sickos who want a ransom of Mommy eating bugs.)
3. Would you have one of your fingers surgically removed if it guaranteed immunity from all major diseases?
Maybe…won't it grow back? I think I might.
UPDATE: Um…no. Sorry, but every time I read this, I read "fingernail" and not "finger" (which is why I said it would grow back). Finger? NO WAY. I have a phobia about hand injuries between my interpreting job (that I used to have) and playing piano since the third grade. Now that I have properly read the question, I am DEFINITELY saying NO!
4. Would you be willing to give up all television for 5 years if it would induce someone to provide for 1,000 starving children?
Sure! Does that mean I can't have a DVR with a huge hard drive? I suppose if I miss anything THAT badly, I'll just get the DVD's. Now, can my CHILDREN live without Spongebob for 5 years? I know they can…but do THEY know that? Different story.
man…5 years without a single sporting event on TV…bummer…But I'd do it for the kids! 😉
5. Would you accept $1 million to leave the country and never set foot in it again?
Leave America for only $1 million dollars? Who asked THIS one? Dr. Evil?
No way, Jose! This is the greatest country on earth! As long as I'm free to live as God wants me to live and raise my children in the manner He sees fit, I'm here for the long haul, baby!
If you decide to do this, leave a comment so I can check out your answers, too. Why? Cuz I'm nosy, that's why!


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The Russia Investigations: Sessions On Edge, Bannon Exiled And Internecine CombatTrimis la 07.01.2018 de admin.
Attorney General Jeff Sessions holds a news conference at the Department of Justice on December 15, 2017, in Washington, D.C.
Chip Somodevilla/Getty Images
This week in the Russia investigations: Big problems for Sessions, Bannon cut adrift and Republicans search for more weapons to fire.
Living on the edge
A lighthouse can stand safely on a barrier island one morning and then when a big storm blows through, be teetering at land's end by the next.
Following the heavy cyclone of news this week, dawn in Washington, D.C., on Saturday found Attorney General Jeff Sessions on the slippery sand — and that could also mean peril for Justice Department special counsel Robert Mueller.
An explosive New York Times scoop revealed that Sessions tried to smear then-FBI Director James Comey before he was fired. The report, by Michael Schmidt, also said President Trump ordered White House counsel Don McGahn to lean on Sessions not to recuse himself from the Russia probe, and when Sessions did recuse, the president fustigated him. Sessions offered to quit but Trump said no.
So not only is Sessions persona non grata with the president — that's been the case for months. Now the public and people inside the Justice Department know Sessions was actively trying to undermine his own FBI director, as part of a pattern of conduct directed by Trump — who himself had asked Comey to lay off then-national security adviser Mike Flynn, then fired Comey, etc.
All this could make life very uncomfortable for Sessions inside DOJ and with the FBI. A small but vocal coterie of House Republicans has already been calling for Sessions' head. (They have no vote but they do keep the anti-Sessions drumbeat going inside the conservative sphere.)
Plus Trump did not invite Sessions to a retreat he's holding over the weekend at Camp David. Plus EPA Administrator Scott Pruitt felt comfortable enough with this state of play to wink and nod to Politico about how he'd be interested in becoming attorney general ... if the job were open.
What does it all mean? Sessions has been in hot water before with Trump but came through it, in part thanks to steadfast support from his longtime allies in the Senate. How strong is that firewall now? Judiciary Committee Chairman Chuck Grassley, R-Iowa, has said he had no plans to confirm a new attorney general. And Sen. Cory Gardner, R-Colo., has threatened to hold up all Justice Department nominees after Sessions rescinded earlier permissive guidelines on marijuana enforcement.
So if Sessions were to go for real this time, Trump might not be able to quickly and easily appoint someone else — someone not recused from the Russia probe — to wrangle the Justice Department on the president's behalf. But if the political dynamics change, that could change the play for the White House. As NPR's Carrie Johnson has reported, replacing the leadership at Justice is one way that Trump could try to control or get rid of Mueller.


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Diagnosis of asthma and allergies
New equipment for the diagnosis of the type of allergen recently received regional center laboratory-based technologies Krasnodar children's hospital number 1. The issue of how to organize free examination of children. Automatic analyzer sets the kind of allergen in blood, as it is intended for the diagnosis of asthma. Daily device 400 may perform a test, the panel comprising 660 to 20 allergens and autoimmune diseases.
The University of Southampton scientists a breakthrough in the field of asthma treatment approaches that will allow to develop new ways to fight the disease. In their view, the removal of ADAM33 gene can prevent the development of asthma. The gene, which drew the attention of specialists, responsible for the production of particles that attach to the airway walls. If his "turn off" disease in rodents is eliminated. ADAM33 alters airway without causing inflammation. Further studies may lead to new methods for the treatment of bronchial asthma.
Currently, there are more "intelligent" inhalers for asthma and chronic lung disease, and manufacturers strive to outrun each other in the invention of gadgets. An urgent problem is the improper use of devices to patients with asthma and COPD. According to experts, taking medication adherence will provide savings of 19 billion dollars a year in the US alone. High-tech innovations allow you to record doses, use a variety of sensors to monitor the flow of the drug, to conduct ambient air monitoring online. The data is stored on remote servers using cloud technologies. Large manufacturers closely collaborate with IT-companies to get ahead of the competition, because, in their opinion, the ability to control the use of inhalers by physicians and patients will justify the cost of medicines to the government and insurance companies.
Johns Hopkins experts have found out - the people living near active wells with natural gas, suffer from asthma attacks in some times more frequently than others. Specialists of the data were collected from medical records in Pennsylvania for the period 2005-2012g.g. It was found that among people from asthma living in the area affected more than 35,000 people from 5 to 90 years. Most asthma attacks flowed in a gentle manner, but the 4782 episode was severe, people hospitalized. 1870 people, without the need for hospitalization, had a mild form of asthma. In addition to the effects of the gas, other possible risk factors were taken into account - accommodation near major roads, the presence of asthma and smoking relatives.Scientists want to understand the exact causes of this relationship for the development of new safety measures.
The German League for the respiratory tract (DAL) and the German Society of Pulmonology and treatment of respiratory diseases (DGP) have developed new recommendations for the treatment of asthma, based on actual observations. The old system will be retained, but adjustments will be made to it. Use of theophylline, such as now assigned with great caution and a smaller dosages. This new patients prescribed the drug is not recommended to continue treatment for people who have had it before without any complications. Patients with a mild form of the disease in order to prevent damage to the lungs recommend taking inhaled corticosteroids in small doses in asthma fifth stage to destinations added antibody mepolizumab. Patients with the disease first degree only recommended medications fenoterol, salbutamol and terbutaline. The alternative therapy with cortisone serve leukotriene receptor antagonists. Starting from the third stage of asthma, in addition to the treatment of beta-2-antagonists, short-acting, it recommended a combination of inhaled corticosteroids and formoterol. For long-term therapy experts have approved the combination of inhaled corticosteroids and beta-2-simpatomimetrikov.
Scientists came to the conclusion that the beard in men can lower the risk of asthma and allergic episodes. As a kind of filter, beard holds small particles of dust and pollen, which has a positive effect on the condition of patients with bronchial asthma. In addition, experts from the University of Southern Queensland found: on the face of the vegetation reduces the risk of skin cancer because blocks 95% of ultraviolet radiation.
Some experts believe that eating foods glyutenosoderzhaschih babies up to 6 months leads to the development of their asthma, bronchitis and diabetes. According to scientists, the child's body can not cope with gluten, which is why disrupted immune system. It is noted that the consumption of such food the child's mother to infant health is not affected.
The structure of the elusive virus associated with severe acute exacerbations of asthma and respiratory infections in children, was found by a group of researchers from the University of Wisconsin-Madison and Purdue University. The findings provide the basis for the development of new antiviral drugs and vaccines. The virus is resistant to current antiviral drugs, there is no vaccine against it. It was opened 10 years ago and, according to experts, is responsible for 50-85% of all childhood hospital admissions for asthma. Studies show that people infected with the virus, have more severe symptoms of the disease. The information provides the basis for the beginning of new large research aimed at the development of vaccines and antiviral drugs, in particular, for the prevention of asthma exacerbations. It turned out that, unlike conventional rhinoviruses, has spikes on the surface of the particles. This and other modifications of its surface to help explain why clinical trials have failed antiviral drugs when exposed to the specimen. Also found: 30% of the virus particles are empty and do not contain genetic material. Such particles are not able to cause infection, but may be immune Manco - distracting the body to fight the non-infectious virus particles, allowing the infectious agent in the body activated.


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2007 Volkswagen City Golf Owners Manual - This is an online manual book guide for 2007 Volkswagen City Golf Owners Manual. Here you are not only able to download its free owners manual, but you also can read few review of it. Here is the review.
2007 Volkswagen City Golf. This Volkswagen has a rather unusual design problem. Because the front door frames cover the A-pillars, snow accumulates under the frame to plop down on your hand or cascade inside when you open the door. From a safety standpoint, the City Golf comes equipped with dual front airbags, five head restraints, and four-wheel anti lock disc brakes. Side and curtain airbags are available as options. The rear head restraints are too far back from the head. The automatic transmission usually shifts smoothly and is well suited to the engine. However, when coming to a complete stop or braking sharply, you clearly feel it downshift.
Download 2007 Volkswagen City Golf Owners Manual