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Sund Aldring > Publikationer > Videnskabelige publikationer > Publikationer 2010
Publications 2010
The list of publications by scientists from Center for Healthy Aging is only in English as most publications are published in English.
Listen over videnskabelige publikationer af forskere fra Center for Sund Aldring er kun på engelsk, da de fleste publikationer kun bliver offentliggjort på engelsk.
- Program 1a - Molecular and Cellular: Molecular Aging
- Program 1b - Molecular and Cellular: Neurobiology
- Program 2 - Molecular and Cellular: Muscle and Matrix
- Program 3 - Body and Life
- Program 4 - Society and Culture
- Program 5 - Health Promotion and Innovation
Program 1a - Molecular and Cellular: Molecular Aging
Identifying patients with therapy-resistant depression by using factor analysis. Andreasson K, Liest V, Lunde M, Martiny K, Unden M, Dising S, Bech P. 2010 Nov.
INTRODUCTION: Attempts to identify the factor structure in patients with treatment-resistant depression have been very limited. METHODS: Principal component analysis was performed using the baseline datasets from 3 add-on studies [2 with repetitive transcranial magnetic stimulation and one with transcranial pulsed electromagnetic fields (T-PEMF)], in which the relative effect as percentage of improvement during the treatment period was analysed...
Associations between labial and whole salivary flow rates, systemic diseases and medications in a sample of older people. Smidt D, Torpet LA, Nauntofte B, Heegaard KM, Pedersen AM. 2010 Oct.
OBJECTIVE: To investigate the associations between age, gender, systemic diseases, medications and labial and whole salivary flow rates in older people. METHODS: Unstimulated labial (LS) and unstimulated (UWS) and chewing-stimulated (SWS) whole salivary flow rates were measured in 389 randomly selected community-dwelling Danish women and 279 men aged 65-97 years. Systemic diseases, medications (coded according to the Anatomical Therapeutic Chemical (ATC) Classification System), tobacco and alcohol consumption were registered..
Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.Yang JL, Tadokoro T, Keijzers G, Mattson MP, Bohr VA. 2010 Sep 3.
Glutamate, the major excitatory neurotransmitter in the brain, activates receptors coupled to membrane depolarization and Ca(2+) influx that mediates functional responses of neurons including processes such as learning and memory. Here we show that reversible nuclear oxidative DNA damage occurs in cerebral cortical neurons in response to transient glutamate receptor activation using non-toxic physiological levels of glutamate...
Helicobacter pylori infection generates genetic instability in gastric cells. Machado AM, Figueiredo C, Seruca R, Rasmussen LJ. 2010 Aug.
The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis. Gastric cancer shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair pathways. As such, this review highlights the consequences of H. pylori infection on the integrity of DNA in the host cells...
The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism. Desler C, Lykke A, Rasmussen LJ. 2010 Aug.
Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis...
BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells. Chu WK, Hanada K, Kanaar R, Hickson ID. 2010 Aug.
In this study, we report the characterization of mouse embryonic stem cells with disruption of Blm and/or Rad54 genes. We show that Blm has roles both upstream and downstream of the Rad54 protein, a core HR factor...
Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage. Skovgaard T, Rasmussen LJ, Munch-Petersen B. 2010 Jun.
Balanced deoxynucleotide pools are known to be important for correct DNA repair, and deficiency for some of the central enzymes in deoxynucleotide metabolism can cause imbalanced pools, which in turn can lead to mutagenesis and cell death. Here we show that cells deficient for the thymidine salvage enzyme thymidine kinase 1 (TK1) are more resistant to UV-induced DNA damage than TK1 positive cells although they have thymidine triphosphate (dTTP) levels of only half the size of control cells...
VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy. Cao R, Xue Y, Hedlund EM, Zhong Z, Tritsaris K, Tondelli B, Lucchini F, Zhu Z, Dissing S, Cao Y. 2010 Jan.
Here, we show that systemic delivery of VEGF and placental growth factor (PlGF) by protein implantation, tumors, and adenoviral vectors ablates pericytes from the mature retinal vasculature through the VEGF receptor 1 (VEGFR1)-mediated signaling pathway, leading to increased vascular leakage. In contrast, we demonstrate VEGF receptor 2 (VEGFR2) is primarily expressed in nonvascular photoreceptors and ganglion cells. Moreover, blockade of VEGFR1 but not VEGFR2 significantly restores pericyte saturation in mature retinal vessels...
Program 1b - Molecular and Cellular: Neurobiology
Glial and neuronal control of brain blood flow. Attwell D, Buchan AM, Charpak S, Lauritzen M, MacVicar BA, Newman EA. 2010 Nov.
Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders....
Program 2 - Molecular and Cellular: Muscle and Matrix
Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight. Sonne MP, Højbjerre L, Alibegovic AC, Vaag A, Stallknecht B, Dela F. 2010.
Low birth weight (LBW) is associated with increased risk of type 2 diabetes and cardiovascular disease. We studied endothelial function and insulin sensitivity in young men with LBW (n = 22) and controls (n = 22)...
Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial. Helmark IC, Mikkelsen UR, Børglum J, Rothe A, Petersen MC, Andersen O, Langberg H, Kjaer M. 2010.
The microdialysis method was applied to the human knee joint with osteoarthritis (OA) in order to reveal changes in biochemical markers of cartilage and inflammation, intraarticularly and in the synovium, in response to a single bout of mechanical joint loading.
Validation of the Falls Efficacy Scale and Falls Efficacy Scale International in geriatric patients with and without cognitive impairment: results of self-report and interview-based questionnaires. Hauer K, Yardley L, Beyer N, Kempen G, Dias N, Campbell M, Becker C, Todd C. 2010.
Frail, old patients with and without cognitive impairment are at high risk of falls and associated medical and psychosocial issues. The lack of adequate, validated instruments has partly hindered research in this field. So far no questionnaire documenting fall-related self-efficacy/fear of falling has been validated for older persons with cognitive impairment or for different administration methods such as self-report or interview. OBJECTIVE: To validate the self-report and interview version of the Falls Efficacy Scale (FES) and the Falls Efficacy Scale International Version (FES-I) in frail geriatric patients with and without cognitive impairment.
Tensile properties of human collagen fibrils and fascicles are insensitive to environmental salts. Svensson RB, Hassenkam T, Grant CA, Magnusson SP. 2010 Dec.
[I]n this study, we focus on the tensile mechanical properties of two hierarchical levels from human patellar tendon, namely: individual collagen fibrils and fascicles. Investigations on collagen fibrils and fascicles were made at pH 7.4 in solutions of phosphate-buffered saline at three different concentrations as well as two HEPES buffered solutions containing NaCl or NaCl + CaCl2....
Increased cellular proliferation in rat skeletal muscle and tendon in response to exercise: use of FLT and PET/CT. Skovgaard D, Bayer ML, Mackey AL, Madsen J, Kjaer M, Kjaer A. 2010 Dec.
The purpose of this study is to investigate exercise-induced cellular proliferation in rat skeletal muscle/tendon with the use of 3'-[F-18]fluoro-3'deoxythymidine (FLT) and to quantitatively study concomitant changes in the proliferation-associated factor, Ki67...
Distribution of myogenic progenitor cells and myonuclei is altered in women with vs. those without chronically painful trapezius muscle. Mackey AL, Andersen LL, Frandsen U, Suetta C, Sjøgaard G. 2010 Dec.
This study investigated the distribution of satellite cells (SCs), myonuclei, and macrophages in muscle biopsies from the trapezius muscle of 42 women performing repetitive manual work, diagnosed with trapezius myalgia (MYA; 44 ± 8 yr; mean ± SD) and 20 matched healthy controls (CON; 45 ± 9 yr). Our hypothesis was that muscle of MYA, in particular type I fibers, would demonstrate higher numbers of SCs, myonuclei, and macrophages compared with CON...
Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining. Hvid L, Aagaard P, Justesen L, Bayer ML, Andersen JL, Ørtenblad N, Kjaer M, Suetta C. 2010 Dec.
Very little attention has been given to the combined effects of aging and disuse as separate factors causing deterioration in muscle mechanical function. Thus the purpose of this study was to investigate the effects of 2 wk of immobilization followed by 4 wk of retraining on knee extensor muscle mechanical function (e.g., maximal strength and rapid force capacity) and muscle fiber morphology in 9 old (OM: 67.3 ± 1.3 yr) and 11 young healthy men (YM: 24.4 ± 0.5 yr) with comparable levels of physical activity....
Skeletal muscle myofibrillar and sarcoplasmic protein synthesis rates are affected differently by altitude-induced hypoxia in native lowlanders. Holm L, Haslund ML, Robach P, van Hall G, Calbet JA, Saltin B, Lundby C. 2010 Dec.
As a consequence to hypobaric hypoxic exposure skeletal muscle atrophy is often reported. The underlying mechanism has been suggested to involve a decrease in protein synthesis in order to conserve O(2). With the aim to challenge this hypothesis, we applied a primed, constant infusion of 1-(13)C-leucine in nine healthy male subjects at sea level and subsequently at high-altitude (4559 m) after 7-9 days of acclimatization....
GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients. Doessing S, Holm L, Heinemeier KM, Feldt-Rasmussen U, Schjerling P, Qvortrup K, Larsen JO, Nielsen RH, Flyvbjerg A, Kjaer M. 2010 Dec.
We hypothesized that the local production of collagen is associated with the level of GH/IGF1.DESIGN AND METHODS: As primary outcomes, collagen mRNA expression and collagen protein fractional synthesis rate (FSR) were determined locally in skeletal muscle and tendon in nine ACRO and nine GHD patients. Moreover, muscle myofibrillar protein synthesis and tendon collagen morphology were determined...
Intermuscular force transmission between human plantar flexor muscles in vivo. Boejsen-Moeller J, Schwartz S, Kalliokoski K, Finni T, Magnusson SP. 2010 Dec.
The exact mechanical function of synergist muscles within a human limb in vivo is not well described. Recent studies indicate the existence of a mechanical interaction between muscle actuators that may have functional significance and further play a role for injury mechanisms. The purpose of the present study was to investigate if intermuscular force transmission occurs within and between human plantarflexor muscles in vivo...
Impact of physical inactivity on subcutaneous adipose tissue metabolism in healthy young male offspring of patients with type 2 diabetes. Højbjerre L, Sonne MP, Alibegovic AC, Dela F, Vaag A, Meldgaard JB, Christensen KB, Stallknecht B. 2010 Nov.
OBJECTIVE: Physical inactivity is a risk factor for type 2 diabetes and may be more detrimental in first-degree relative (FDR) subjects, unmasking underlying defects of metabolism. Using a positive family history of type 2 diabetes as a marker of increased genetic risk, the aim of this study was to investigate the impact of physical inactivity on adipose tissue (AT) metabolism in FDR subjects...
Early osteoarthritis and microdialysis: a novel in vivo approach for measurements of biochemical markers in the perisynovium and intraarticularly. Helmark IC, Mikkelsen UR, Krogsgaard MR, Belhage B, Petersen MC, Langberg H, Kjaer M. 2010 Nov.
The microdialysis technique was evaluated as a possible method to obtain local measurements of biochemical markers from knee joints with degenerative changes. Seven patients scheduled for arthroscopy of the knee due to minor to moderate degenerative changes had microdialysis catheters inserted under ultrasonographic guidance, intraarticularly and in the synovium-close tissue....
Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men. Alibegovic A.C., Sonne, M.P., Højbjerre, L., Bork-Jensen, J., Jacobsen, S., Nilsson, E., Færch, K., Hiscock, N.J., Mortensen, B., Friedrichsen, M., Stallknecht, B., Dela, F., Vaag, A. 2010 Nov.
Physical inactivity is a risk factor for insulin resistance. We examined the effect of 9 days of bed rest on basal and insulin-stimulated expression of genes potentially involved in insulin action by applying hypothesis-generating microarray in parallel with candidate gene real-time PCR approaches in 20 healthy young men...
Hip abduction strength training in the clinical setting: with or without external loading? Thorborg K, Bandholm T, Petersen J, Weeke KM, Weinold C, Andersen B, Serner A, Magnusson SP, Hölmich P. 2010 Oct.
The side-lying hip abduction exercise is one of the most commonly used exercises in rehabilitation to increase hip abduction strength, and is often performed without external loading. The aim of this study was to compare the effect of 6 weeks of side-lying hip abduction training, with and without external loading, on hip abduction strength in healthy subjects...
Intake of total dietary sugar and fibre is associated with insulin resistance among Danish 8-10- and 14-16-year-old girls but not boys. European Youth Heart Studies I and II. Kynde I, Johnsen NF, Wedderkopp N, Bygbjerg IB, Helge JW, Heitmann BL. 2010 Oct.
OBJECTIVE: To examine the dietary intake of total sugar, added sugar, non-added sugar and starch as well as dietary fibre and glycaemic index (GI) and their respective associations with insulin resistance. DESIGN: Mixed linear models were used to study both cross-sectional and prospective associations between carbohydrate components and insulin resistance separately in girls and boys. Diet was assessed by a single 24 h recall interview and insulin resistance was calculated using the homoestasis model assessment (HOMA)...
Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes. Rabøl R, Boushel R, Almdal T, Hansen CN, Ploug T, Haugaard SB, Prats C, Madsbad S, Dela F. 2010 Sep.
AIM: Skeletal muscle insulin resistance has been linked to mitochondrial dysfunction. We examined how improvements in muscular insulin sensitivity following rosiglitazone (ROSI) or pioglitazone (PIO) treatment would affect muscle mitochondrial function in patients with type 2 diabetes mellitus (T2DM)...
Measuring protein breakdown rate in individual proteins in vivo. Holm L, Kjaer M. 2010 Sep.
PURPOSE OF REVIEW: To outline different approaches of how protein breakdown can be quantified and to present a new approach to determine the fractional breakdown rate of individual slow turnover proteins in vivo.
Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes. Hey-Mogensen M, Højlund K, Vind BF, Wang L, Dela F, Beck-Nielsen H, Fernström M, Sahlin K. 2010 Sep.
AIM/HYPOTHESIS: Studies have suggested a link between insulin resistance and mitochondrial dysfunction in skeletal muscles. Our primary aim was to investigate the effect of aerobic training on mitochondrial respiration and mitochondrial reactive oxygen species (ROS) release in skeletal muscle of obese participants with and without type 2 diabetes....
Arm and leg substrate utilization and muscle adaptation after prolonged low-intensity training. Helge JW. 2010 Aug.
This review will focus on current data where substrate metabolism in arm and leg muscle is investigated and discuss the presence of higher carbohydrate oxidation and lactate release observed during arm compared with leg exercise. Furthermore, a basis for a possible difference in substrate partitioning between endogenous and exogenous substrate during arm and leg exercise will be debated. Moreover the review will probe if differences between arm and leg muscle are merely a result of different training status rather than a qualitative difference in limb substrate regulation...
Muscle ceramide content in man is higher in type I than type II fibers and not influenced by glycogen content. Nordby P, Prats C, Kristensen D, Ekroos K, Forsberg G, Andersen JL, Ploug T, Dela F, Storlien L, Helge JW. 2010 Jul.
Human muscle is studied during glycogen depletion and repletion to understand the influence of exercise and muscle glycogen on total ceramide content. In addition, fiber-type-specific ceramide storage is investigated. Ten healthy males (26.4 +/- 0.9 years, BMI 24.4 +/- 0.7 kg m(-2) and VO2max 57 +/- 2 mL O2 min(-1) kg(-1)) participated in the study...
Regulation of human skeletal muscle perfusion and its heterogeneity during exercise in moderate hypoxia. Heinonen IH, Kemppainen J, Kaskinoro K, Peltonen JE, Borra R, Lindroos M, Oikonen V, Nuutila P, Knuuti J, Boushel R, Kalliokoski KK. 2010 Jul.
Although many effects of both acute and chronic hypoxia on the circulation are well characterized, the distribution and regulation of blood flow (BF) heterogeneity in skeletal muscle during systemic hypoxia is not well understood in humans. We measured muscle BF within the thigh muscles of nine healthy young men using positron emission tomography during one-leg dynamic knee extension exercise in normoxia and moderate physiological systemic hypoxia (14% O(2) corresponding to approximately 3,400 m of altitude) without and with local adenosine receptor inhibition with femoral artery infusion of aminophylline...
Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients. Dela F, Stallknecht B. 2010 Jul.
Physical training affects insulin secretion and action, but there is a paucity of data on the direct effects in skeletal muscle and adipose tissue and on the effect of training in first-degree relatives (FDR) of patients with type 2 diabetes. We studied insulin action at the whole body level and peripherally in skeletal muscle and adipose tissue as well as insulin-secretory capacity in seven FDR and eight control (CON) subjects before and after 12 wk of endurance training....
Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity. Kraunsøe R, Boushel R, Hansen CN, Schjerling P, Qvortrup K, Støckel M, Mikines KJ, Dela F. 2010 Jun.
Adipose tissue exerts important endocrine and metabolic functions in health and disease. Yet the bioenergetics of this tissue is not characterized in humans and possible regional differences are not elucidated. Using high resolution respirometry, mitochondrial respiration was quantified in human abdominal subcutaneous and intra-abdominal visceral (omentum majus) adipose tissue from biopsies obtained in 20 obese patients undergoing bariatric surgery....
FAT/CD36 is localized in sarcolemma and in vesicle-like structures in subsarcolemma regions but not in mitochondria. Jeppesen J, Mogensen M, Prats C, Sahlin K, Madsen K, Kiens B. 2010 Jun.
The primary aim of the present study was to investigate in which cellular compartments fatty acid trans-locase CD36 (FAT/CD36) is localized. Intact and fully functional skeletal muscle mitochondria were isolated from lean and obese female Zucker rats and from 10 healthy male individuals...
The initiation of embryonic-like collagen fibrillogenesis by adult human tendon fibroblasts when cultured under tension. Bayer ML, Yeung CY, Kadler KE, Qvortrup K, Baar K, Svensson RB, Magnusson SP, Krogsgaard M, Koch M, Kjaer M. 2010 Jun.
Tendon fibroblasts synthesize collagen and form fibrils during embryonic development, but to what extent mature fibroblasts are able to recapitulate embryonic development and develop normal tendon structure is unknown. The present study examined the capability of mature human tendon fibroblasts to initiate collagen fibrillogenesis when cultured in fixed-length fibrin gels...
Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation. Axelsen LN, Lademann JB, Petersen JS, Holstein-Rathlou NH, Ploug T, Prats C, Pedersen HD, Kjølbye AL. 2010 Jun.
Metabolic syndrome and obesity-related diseases are affecting more and more people in the Western world. The basis for an effective treatment of these patients is a better understanding of the underlying pathophysiology. Here, we characterize fructose- and fat-fed rats (FFFRs) as a new animal model of metabolic syndrome. Sprague-Dawley rats were fed a 60 kcal/100 kcal fat diet with 10% fructose in the drinking water...
Fat oxidation at rest predicts peak fat oxidation during exercise and metabolic phenotype in overweight men. Rosenkilde M, Nordby P, Nielsen LB, Stallknecht BM, Helge JW. 2010 May.
OBJECTIVE: To elucidate if fat oxidation at rest predicts peak fat oxidation during exercise and/or metabolic phenotype in moderately overweight, sedentary men.
The pathogenesis of tendinopathy: balancing the response to loading. Magnusson SP, Langberg H, Kjaer M. 2010 May.
Despite the ability of tendons to adapt to loading, repetitive use often results in injuries, such as tendinopathy, which is characterized by pain during activity, localized tenderness upon palpation, swelling and impaired performance...
Childhood hypo-adiponectinaemia but not hyper-leptinaemia is associated with insulin insensitivity 6 years later. Kynde I, Heitmann BL, Bygbjerg IC, Andersen LB, Helge JW.2010 May.
BACKGROUND: Biomarkers of metabolism and inflammation may predict children with increased diabetes risk.
Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C. 2010 Apr.
Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-gamma1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells...
Muscle function and postural balance in lifelong trained male footballers compared with sedentary elderly men and youngsters. Sundstrup E, Jakobsen MD, Andersen JL, Randers MB, Petersen J, Suetta C, Aagaard P, Krustrup P. 2010 Apr.
The present study investigated whether elderly subjects exposed to lifelong football training have better rapid muscle force characteristics, body composition and postural stability in comparison with untrained elderly....
Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients. Suetta C, Clemmensen C, Andersen JL, Magnusson SP, Schjerling P, Kjaer M. 2010 Apr.
Hypertrophy of developing skeletal muscle involves stimulation by insulin-like growth factor-I (IGF-I), however, the role of IGF-I in adult muscle is less clarified. In the present study, the mRNA splice variants of IGF-I (IGF-IEa and MGF) and the changes in muscle fiber cross sectional area after 12 weeks of training were studied in elderly post-operative patients...
Effect of 10 days of bed rest on metabolic and vascular insulin action: a study in individuals at risk for type 2 diabetes. Sonne MP, Alibegovic AC, Højbjerre L, Vaag A, Stallknecht B, Dela F. 2010 Apr.
Physical inactivity is a known risk factor for type 2 diabetes. We studied whole body and forearm insulin sensitivity in subjects at increased risk for type 2 diabetes [persons with low birth weight (LBW group; n = 20) and first-degree relatives to type 2 diabetic patients (FDR group; n = 13)] as well as a control (CON) group (n = 20) matched for body mass index, age, and physical activity levels before and after 10 days of bed rest...
Fibril morphology and tendon mechanical properties in patellar tendinopathy: effects of heavy slow resistance training. Kongsgaard M, Qvortrup K, Larsen J, Aagaard P, Doessing S, Hansen P, Kjaer M, Magnusson SP. 2010 Apr.
BACKGROUND: Patellar tendinopathy is characterized by pathologic abnormalities. Heavy slow resistance training (HSR) is effective in the management of patellar tendinopathy, but the underlying functional mechanisms remain elusive.
The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest. Alibegovic AC, Sonne MP, Højbjerre L, Hansen T, Pedersen O, Van Hall G, Holst JJ, Stallknecht B, Dela F, Vaag A. 2010 Apr.
OBJECTIVE:The aim of this study was to determine whether the type 2 diabetes-associated T-allele of transcription factor 7-like 2 (TCF7L2) rs7903146 associates with impaired insulin secretion to compensate for insulin resistance induced by bed rest...
Time trends in physical activity in leisure time in the Danish population from 1987 to 2005. Petersen CB, Thygesen LC, Helge JW, Grønbaek M, Tolstrup JS. 2010 Mar.
AIMS: To examine time trends in leisure-time physical activity in the Danish population from 1987 to 2005. METHODS: Analyses were based on four national representative population surveys of 4752 respondents in 1987, 4667 in 1994, 16,688 in 2000, and 14,566 in 2005....
Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle. Nielsen J, Mogensen M, Vind BF, Sahlin K, Højlund K, Schrøder HD, Ortenblad N. 2010 Mar.
The purpose of the study was to investigate the effect of aerobic training and type 2 diabetes on intramyocellular localization of lipids, mitochondria, and glycogen. Obese type 2 diabetic patients (n = 12) and matched obese controls (n = 12) participated in aerobic cycling training for 10 wk. Endurance-trained athletes (n = 15) were included for comparison...
Increased rate of whole body lipolysis before and after nine days of bed rest in healthy young men born with low birth weight. Alibegovic A.C., Højbjerre, L., Sonne, M., Hall, G. van, Alsted, T.J., Kiens, B., Stallknecht, B., Dela, F., Vaag, A. 2010 Mar.
Individuals born with low birth weight (LBW) are at risk of developing type 2 diabetes mellitus (T2D), which may be precipitated by physical inactivity. Twenty-two LBW subjects and twenty-three controls were studied before and after bed rest by the hyperinsulinemic euglycemic clamp combined with indirect calorimetry and infusion of stable isotope tracers and preceded by an intravenous glucose tolerance test...
Regional anatomic differences in skeletal muscle mitochondrial respiration in type 2 diabetes and obesity. Rabøl R, Larsen S, Højberg PM, Almdal T, Boushel R, Haugaard SB, Andersen JL, Madsbad S, Dela F. 2010 Feb.
Previous studies on leg skeletal musculature have demonstrated mitochondrial dysfunction associated with type 2 diabetes mellitus (T2DM), but it is not known whether mitochondrial dysfunction is present in the upper extremities. Objective: The aim of the study was to compare mitochondrial respiration and markers of mitochondrial content in skeletal muscle of arm and leg in patients with T2DM and obese control subjects...
A COX-2 inhibitor reduces muscle soreness, but does not influence recovery and adaptation after eccentric exercise. Paulsen G, Egner IM, Drange M, Langberg H, Benestad HB, Fjeld JG, Hallén J, Raastad T. 2010 Feb.
The aim of this study was to investigate the effect of a cyclooxygenase (COX)-2 inhibitor on the recovery of muscle function, inflammation, regeneration after, and adaptation to, unaccustomed eccentric exercise. Thirty-three young males and females participated in a double-blind, placebo-controlled experiment. Seventy unilateral, voluntary, maximal eccentric actions with the elbow flexors were performed twice (bouts 1 and 2) with the same arm, separated by 3 weeks...
Contraction intensity and feeding affect collagen and myofibrillar protein synthesis rates differently in human skeletal muscle. Holm L, van Hall G, Rose AJ, Miller BF, Doessing S, Richter EA, Kjaer M. 2010 Feb.
Exercise stimulates muscle protein fractional synthesis rate (FSR), but the importance of contractile intensity and whether it interplays with feeding is not understood. This was investigated following two distinct resistance exercise (RE) contraction intensities using an intrasubject design in the fasted (n = 10) and fed (n = 10) states...
Comparison of exogenous adenosine and voluntary exercise on human skeletal muscle perfusion and perfusion heterogeneity. Heinonen I, Kemppainen J, Kaskinoro K, Peltonen JE, Borra R, Lindroos MM, Oikonen V, Nuutila P, Knuuti J, Hellsten Y, Boushel R, Kalliokoski KK. 2010 Feb.
In the present study, we measured thigh muscle capillary nutritive blood flow in nine healthy young men using PET at rest and during the femoral artery infusion of adenosine (1 mg min(-1) l thigh volume(-1)), which has previously been shown to induce a maximal whole thigh blood flow of approximately 8 l/min. This response was compared with the blood flow induced by moderate- to high-intensity one-leg dynamic knee extension exercise...
Role of the nervous system in sarcopenia and muscle atrophy with aging - training as a countermeasure. Aagaard P, Suetta C, Magnusson SP, Kjaer M. 2010 Feb.
The impairment in muscle mechanical function is accompanied and partly caused by an age-related loss in neuromuscular function that comprise changes in maximal MN firing frequency, agonist muscle activation, antagonist muscle coactivation, force steadiness, and spinal inhibitory circuitry. Strength training appears to elicit effective countermeasures in elderly individuals even at a very old age (>80 years) by evoking muscle hypertrophy along with substantial changes in neuromuscular function, respectively...
Viscoelastic behavior of discrete human collagen fibrils. Svensson RB, Hassenkam T, Hansen P, Peter Magnusson S. 2010 Jan.
In the present work an atomic force microscopy (AFM) approach was used for tensile testing of two human patellar tendon fibrils. Fibrils were obtained from intact human fascicles, without any pre-treatment besides frozen storage. In the dry state a single isolated fibril was anchored to a substrate using epoxy glue, and the end of the fibril was glued on to an AFM cantilever for tensile testing. In phosphate buffered saline, cyclic testing was performed in the pre-yield region at different strain rates, and the elastic response was determined by a stepwise stress relaxation test...
Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training. Petersen SG, Saxne T, Heinegard D, Hansen M, Holm L, Koskinen S, Stordal C, Christensen H, Aagaard P, Kjaer M. 2010 Jan.
OBJECTIVE: To investigate changes in levels of serum cartilage oligomeric matrix protein (COMP) and urine c-telopeptide of type-2 collagen (CTX-II) as markers for cartilage turnover in patients with osteoarthritis (OA) of the knee, in response to muscle strength training in combination with treatment with glucosamine, ibuprofen or placebo...
Lower strength of the human posterior patellar tendon seems unrelated to mature collagen cross-linking and fibril morphology. Hansen P, Haraldsson BT, Aagaard P, Kovanen V, Avery NC, Qvortrup K, Larsen JO, Krogsgaard M, Kjaer M, Peter Magnusson S. 2010 Jan.
We hypothesized that changes in fibril morphology and collagen cross-linking would parallel differences in material strength between the anterior and posterior tendon. Tendon fascicles were obtained from elective ACL surgery patients and tested micromechanically. Transmission electron microscopy was used to assess fibril morphology, and collagen cross-linking was determined by HPLC and calorimetry...
Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis. Doessing S, Heinemeier KM, Holm L, Mackey AL, Schjerling P, Rennie M, Smith K, Reitelseder S, Kappelgaard AM, Rasmussen MH, Flyvbjerg A, Kjaer M. 2010 Jan.
To test the hypothesis that GH promotes matrix collagen synthesis in musculotendinous tissue, we investigated the effects of 14 day administration of 33-50 microg kg(-1) day(-1) recombinant human GH (rhGH) in healthy young individuals. rhGH administration caused an increase in serum GH, serum IGF-I, and IGF-I mRNA expression in tendon and muscle. Tendon collagen I mRNA expression and tendon collagen protein synthesis increased by 3.9-fold and 1.3-fold, respectively (P < 0.01 and P = 0.02), and muscle collagen I mRNA expression and muscle collagen protein synthesis increased by 2.3-fold and 5.8-fold, respectively (P < 0.01 and P = 0.06).....
Program 3 - Body and Life
Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. Johannsen TH, Ripa CP, Carlsen E, Starup J, Nielsen OH, Schwartz M, Drzewiecki KT, Mortensen EL, Main KM. 2010.
Background. Our knowledge on long-term outcome in CAH remains incomplete. Methods. In a prospective study (33 CAH patients, 33 age-matched controls), reproductive outcomes, self-rating of genital appearance and function, and sexuality were correlated to degree of initial virilisation, genotype, and surgery...
Time limited psychodynamic group therapy. Jensen HH, Mortensen EL, Lotz M. 2010 Dec.
We explore predictors of participation in additional treatment within one year after termination of 39 sessions of psychodynamic group therapy (n=130)....
Excess mortality rate during adulthood among Danish adoptees. Petersen L, Sørensen TI, Mortensen EL, Andersen PK. 2010 Dec.
The aim was to investigate whether the cohort of domestic adoptees used for these studies in Denmark is similar to the general population with respect to all-cause mortality and cause-specific mortality rates...
A cohort study of leisure time physical activity and depression. Mikkelsen SS, Tolstrup JS, Flachs EM, Mortensen EL, Schnohr P, Flensborg-Madsen T. 2010 Dec.
OBJECTIVE: The objective of the study was to examine the role of leisure time physical activity on the risk of developing depression in a large longitudinal setting. METHODS: A prospective cohort study was used, comprising three updated measures of leisure time physical activity and covariates and 26 years of follow-up data on 18,146 individuals from the Copenhagen City Heart Study, Denmark...
Are negative aspects of social relations predictive of angina pectoris? A 6-year follow-up study of middle-aged Danish women and men. Lund R, Rod NH, Christensen U. 2010 Dec.
During a 6-year follow-up, the authors aimed to assess if negative aspects of social relations were associated with angina pectoris among 4573 middle-aged Danish men and women free of heart disease at baseline in 2000...
Sun protective behaviour in renal transplant recipients. A qualitative study based on individual interviews and the Health Belief Model. Skiveren J, Mortensen EL, Haedersdal M. 2010 Nov.
BACKGROUND: Renal transplant recipients (RTRs) are at high-risk of developing aggressive and potentially lethal non-melanoma skin cancer, which emphasizes the need for consistent sun protective behaviour. OBJECTIVE: To identify factors that exert an influence on the sun protective behaviour of RTRs....
Early identification of non-remission in first-episode psychosis in a two-year outcome study. Simonsen E, Friis S, Opjordsmoen S, Mortensen EL, Haahr U, Melle I, Joa I, Johannessen JO, Larsen TK, Røssberg JI, Rund BR, Vaglum P, McGlashan TH. 2010 Nov.
OBJECTIVE: To identify predictors of non-remission in first-episode, non-affective psychosis. METHOD: During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years
Preventive home visits to older home-dwelling people in Denmark: are invitational procedures of importance? Ekmann A, Vass M, Avlund K. 2010 Nov.
Since 1998 all municipalities in Denmark have been required by law to offer two annual preventive home visits to all home-dwelling citizens aged 75 or over. The influence of invitational procedures on acceptance rates has not been investigated. The aim of this study was to describe and investigate whether different invitational procedures were associated with first preventive home visit acceptance rates....
Late mental health changes in tortured refugees in multidisciplinary treatment. Carlsson JM, Olsen DR, Kastrup M, Mortensen EL. 2010 Nov.
The aim of this study was to examine long-term changes in symptoms of post-traumatic stress disorder, depression, anxiety, and in health-related quality of life in traumatized refugees 23 months after admission to multidisciplinary treatment. The study group comprised 45 persons admitted to the Rehabilitation and Research Centre for Torture Victims in 2001 to 2002....
Mobility disability in midlife: a longitudinal study of the role of anticipated instrumental support and social class. Nilsson CJ, Avlund K, Lund R. 2010 Oct.
On the basis of the evidence of a protective effect of social support on the functional ability of older people and social inequalities in mobility the present study aims to (1) study if onset of mobility disability in a middle-aged cohort is associated with social class and (2) study if anticipation of instrumental support has a protective effect on mobility at 6-year follow-up, and whether this effect is modified by social class....
The importance of individual preferences when evaluating the associations between working hours and indicators of health and well-being. Nabe-Nielsen K, Kecklund G, Ingre M, Skotte J, Diderichsen F, Garde AH. 2010 Oct.
Previous studies indicate that the effect of a given shift schedule may depend on individual factors. The aim of the present study was to investigate whether a misfit between individual preferences and actual working hours affected the association between working hours and self-reported indicators of health and well-being...
Deficient maturation of aspects of attention and executive functions in early onset schizophrenia. Jepsen JR, Fagerlund B, Pagsberg AK, Christensen AM, Nordentoft M, Mortensen EL. 2010 Oct.
The current 5-year follow-up study compared the development of specific cognitive functions in EOS patients (N = 17) from the time of first-episode to chronic phase with that of healthy controls (N = 38) and secondarily to patients with other early onset, non-organic, non-affective psychoses (EOP) (N = 11)...
Occupational position and its relation to mental distress in a random sample of Danish residents. Rugulies R, Madsen IE, Nielsen MB, Olsen LR, Mortensen EL, Bech P. 2010 Aug.
PURPOSE: To analyze the distribution of depressive, anxiety, and somatization symptoms across different occupational positions in a random sample of Danish residents. METHODS: The study sample consisted of 591 Danish residents (50% women), aged 20-65, drawn from an age- and gender-stratified random sample of the Danish population....
Premorbid IQ and adult schizophrenia spectrum disorder: verbal Performance subtests. Sørensen HJ, Mortensen EL, Schiffman J, Ekstrøm M, Denenney D, Mednick SA. 2010 Jun.
The present prospective high-risk study examined associations between childhood scores on five Wechsler Intelligence Scale for Children (WISC) subtests (vocabulary, similarities, block design, object assembly, and mazes) and later development of schizophrenia spectrum disorders (SSD). The sample comprised 244 high-risk or control children who were administered the WISC subtests at age 10 to 13 years in 1972...
Social inequality in onset of mobility disability among older danes: the mediation effect of social relations. Nilsson CJ, Avlund K, Lund R. 2010 Jun.
OBJECTIVE: This article investigates social inequality in onset of mobility disability and in measures of social relations and whether social relations mediated the effect of socioeconomic status on mobility. METHOD: A total of 2,825 nondisabled older men and women, enrolled in the Danish Intervention Study on Preventive Home Visits, constituted the study population...
Early developmental milestones and risk of schizophrenia: a 45-year follow-up of the Copenhagen Perinatal Cohort. Sørensen HJ, Mortensen EL, Schiffman J, Reinisch JM, Maeda J, Mednick SA. 2010 May.
The aim of the present study was to investigate the relationship between age of neuromotor milestone attainment and risk of adult schizophrenia. 5765 mothers of the Copenhagen Perinatal Cohort recorded 12 developmental milestones during the child's first year of life. Cohort members were followed until they were 46-48 years old through record linkage with the Danish Psychiatric Central Research Register...
Can the higher risk of disability onset among older people who live alone be alleviated by strong social relations? A longitudinal study of non-disabled men and women. Lund R, Nilsson CJ, Avlund K. 2010 May.
PURPOSE: to investigate if the increased risk of disability onset among older people who live alone could possibly be moderated by either high social participation or by being satisfied with the social relations. DESIGN AND METHODS: logistic regression models were tested using two waves in a study population of 2,697 non-disabled older men and women from The Danish Longitudinal Study on Preventive Home Visits..
Education reduces the effects of genetic susceptibilities to poor physical health. Johnson W, Kyvik KO, Mortensen EL, Skytthe A, Batty GD, Deary IJ. 2010 Apr.
Greater education is associated with better physical health. This has been of great concern to public health officials. Most demonstrations show that education influences mean levels of health. Little is known about the influence of education on variance in health status, or about how this influence may impact the underlying genetic and environmental sources of health problems. This study explored these influences...
Course of intelligence deficits in early onset, first episode schizophrenia: a controlled, 5-year longitudinal study. Jepsen JR, Fagerlund B, Pagsberg AK, Christensen AM, Hilker RW, Nordentoft M, Mortensen EL. 2010 Apr.
The objective of the current study was to compare the development of intelligence in EOS patients (N = 10) from their first psychotic episode to 5 years of post onset with that of healthy controls (N = 35) and patients who at baseline had been diagnosed with other non-affective psychoses (N = 8)...
Effectiveness of short-term psychodynamic group therapy in a public outpatient psychotherapy unit. Jensen HH, Mortensen EL, Lotz M. 2010 Apr.
BACKGROUND: Short-term psychodynamic group therapy in heterogeneous patient groups is common in the public Danish psychiatric system but is in need of evaluation. AIM: To investigate improvement in 39-session psychodynamic group therapy using three criteria: 1) effect size (Cohen's d), 2) statistically reliable improvement, and 3) clinical significant change (CSC)...
Fatigue in older adults: an early indicator of the aging process? Avlund K. 2010 Apr.
The aim of this paper is to give an overview of research on fatigue in older adults, with a focus on fatigue as an early indicator of the aging process. Fatigue is a strong predictor of functional limitations, disability, mortality, and other adverse outcomes in young-old and old-old populations, between men and women, and in different geographic localities...
Late introduction of complementary feeding, rather than duration of breastfeeding, may protect against adult overweight. Schack-Nielsen L, Sørensen TIa, Mortensen EL, Michaelsen KF. 2010 Mar.
BACKGROUND: Early nutrition may affect the risk of overweight in later life. OBJECTIVE: The objective was to explore the effect of the duration of breastfeeding (BF) and age at introduction of complementary feeding (CF) on body mass index (BMI) during childhood through adulthood...
Emotional distress and quality of life in relatives of patients with severe brain injury: the first month after injury. Norup A, Siert L, Lykke Mortensen E. 2010 Feb.
PRIMARY OBJECTIVE: To investigate emotional distress and quality of life in a sample of Danish relatives of patients with severe brain injury at admission to intensive rehabilitation in the sub-acute phase...
Integration of healthcare rehabilitation in chronic conditions. Frølich A, Høst D, Schnor H, Nørgaard A, Ravn-Jensen C, Borg E, Hendriksen C. 2010 Feb.
Three entities-Bispebjerg University Hospital, the City of Copenhagen, and the GPs in Copenhagen-collaborated on a quality improvement project focusing on integration and implementation of rehabilitation programmes in four conditions...
Gestational weight gain in relation to offspring body mass index and obesity from infancy through adulthood. Schack-Nielsen L, Michaelsen KF, Gamborg M, Mortensen EL, Sørensen TI. 2010 Jan.
We analyzed whether this effect persists into adulthood and is mediated by effects in childhood. DESIGN: The design of the study a prospective birth cohort study established in 1959-1961. SUBJECTS: The subjects were offspring (n = 4234 of whom 2485 had information from the last follow-up) of mothers included in 'The Copenhagen Perinatal Cohort' during pregnancy or at birth...
Program 4 - Society and Culture
Sexede seniorer. Opgør med et tabuiseret felt. Oxlund B. 2010 Oct.
Aldring og seksualitet er begreber, der sjældent optræder i samme sætning. Det skyldes, at ældre menneskers seksuelle aktivitet længe har været et tabuiseret felt...
Time for me to be told off - On putting care into words. (Nu skal jeg ind og have skældud: Om at sætte ord på omsorg). Ludvigsen B, Overgaard Mogensen H. 2010 Apr.
The article throws new light on care and dialogue using the analytical term ''relatedness". Discussion of how to create social relatedness is another way of talking about something akin to what nurses already do, and are aware of, but which they call care and being in dialogue...


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Very rarely are we treated to a nexus of talent that echoes the great duos: Bacharach and David, Webber and Rice, Morrissey and Marr, to name a few. The inability for critics and music services to "pigeonhole" Room 29 is ample evidence of the novel space the album holds; not to say the record companies haven't tried, with made-up categories such as "Classical Crossover." After repeated listenings, Room 29 solidly remains in a category unto itself – a musical and lyrical adventure. Feist pointed out that Room 29 (the album) is actually the soundtrack to Room 29 (the performance), but while the majority of us miss out on the added visceral benefits of a live performance, Room 29 (the album) evokes powerful mental images of our own creation – a unique and personalized Room 29 performance for each listener. The review below is obviously based on our own experience (save a few choice quotes) and our familiarity with the unbelievably high water mark Gonzales sets for himself. Continue reading
Category Archives: Album Reviews
Room 29
Honing and refining his skill, moving from Solo Piano to chamber music and now to voice and piano (and chamber music), Gonzales' trajectory appears to focus on re-introducing classic techniques to new audiences. And one senses that listeners are ready for something with deeper and lasting meaning; not since the heyday of disco have audiences been subjected to deep and relentless domination of dance-oriented 4/4 pop – people are looking for a different relationship with music. Room 29 is a collaborative effort, bringing together the witty and insightful lyrics of Jarvis Cocker and the deep and emotional Gonzales piano that we know and love. From the pre-release tracks, it's easy to hear how well this pairing works, but (as with any Gonzales release), there's a lot of background to discover and layers to peel back – let's have a closer look. Continue reading
Freud Analyzes Chambers
It's curious how a concert can be construed as a therapy session en-masse with characters on both sides of the stage divide standing to benefit. The "psychologist" wears comfortable slippers and sits on a padded leather chair. He or she has a bevy of tools at hand for eliciting responses from audiences, including musical instruments, voice, other musicians, and willing (and not-so-willing) audience members. In North America, traveling illusionists such as "The Amazing Kreskin" or the late "Reveen", blur the lines between entertainer, therapist, and illusionist, often employing therapy or other devices to not only entertain, but also to make grand statements on the nature of consciousness and one's ability to believe. Continue reading
Octave Minds Debut: Inspiring and Evocative
Many of Gonzales' albums have a central theme, much in the same way that many of his songs were driven from a central theme or challenge (e.g. compose an emotional song only on the white keys). In the case of Solo Piano, it's the (apparent) intimacy and solitude of an upright piano, and in "The Unspeakable Chilly Gonzales", it's the insightful and bombastic rapper (with no beats), and so on. The original Boys Noize collaboration, Ivory Tower was also a concept album of sorts – a 'pure' artist struggling with the pressures of becoming an 'Entertainer'. For Ivory Tower, the duo were soundtracking to an actual movie, but in the case of Octave Minds, the music is written to a movie that only exists in our minds. This is much more powerful and effective, as the evocative imagery that comes from within us is shaped from our personal environment and experiences. Without a singer (for the most part), the music is universal as we don't have to strain to interpret words. Continue reading
Octave Minds Think Alike
When we first heard that Chilly Gonzales and Boys Noize were "Working Together" again, we speculated on what the result would be: Touching electronic-infused piano melodies and harmonies. On July 18th. Chilly Gonzales and Boys Noise announced the first freely downloadable single ("In Silence") from their forthcoming album "Octave Minds", which will be released in Sept, 2014. "In Silence" sets the bar very high for the rest of the album, which is sure to be beyond what anyone was expecting. Continue reading
Gonzales Über Alles: Music, Humour, Personality
Gonzales has created a mish-mash of beats, samples, pop melodies and harsh tokes that sticks in your head, sticks to the wall, leaves a mess on the floor, makes long distance phone calls and never does the dishes. You need fun friends like this.
- James Keast – exclaim.ca (2000)
Über Alles signals the imminent rise to world domination of a major talent. Twisted pop genius.
- Dave Stelfox – spannerd.org (2000)
Continue reading
Life, Death, and Wolfstein
"I could live in this parking lot; I could be here, and I cannot"
"Parking Lot" from Wolfstein by Son
There's something to be said about incumbents; the warm robe and worn slippers feeling of comfort and stability that comes with familiarity. But familiarity and conformity have a dark, Faustian side that is inherently accepted by those who choose 'establishment' over innovation and discomfort. Continue reading
Rap's Unspeakable Libretto
A rap rhyme review of "The Unspeakable Chilly Gonzales"
What if your inner voice just started speaking out?
And everyone could hear what you really are about
Would you have the guts to lay it down on wax? Continue reading

subset: commoncrawl


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Are you interested in doing more than the average sightseer on your next vacation? Are you like the rest of us at Texas Book Festival and want to test just how many new books you can fit in your luggage? Then check out some of the best independent bookstores in popular vacation spots for your next get-away (and try to survive this bookshelf envy).
1. The Booksmith – San Francisco, California
Haight-Ashbury, the notorious spot for the conglomeration of hippie culture in the 1960's, is still frequented by tourists and native San Franciscans alike. However, this bookstore sets itself apart from the record stores and small boutiques with its blending of both popular and uncommon literary finds. With an open, comfortable layout, The Booksmith seamlessly fuses the best sellers with genres like photography and science fiction. The Booksmith also sells various unique (and affordable) editions of classics such as Jane Austen or Charles Dickens (you can never own enough copies of Pride and Prejudice).
2. Small World Books – Venice, California
One of the staples of a good independent bookstore is a bookstore cat; Small World Books has this part covered. Tucked inside a restaurant front on the Venice Beach boardwalk, Small World Books is easy to walk past. But, you would miss out on the company of the bookstore cat, aptly named Conan the Librarian. Additionally, the staff is wonderful and motivated to help you find the perfect book. There are also hundreds of staff recommendation cards around the store, so you can find what you're looking for even if a staff member isn't present. You know you'll need a book in your hands when you're confronted with Muscle Beach a little further down the boardwalk.
If you stop in to this 1,000 square feet location, you'll inevitably notice one thing: WORD is small but mighty. The size of WORD only betters the bookstore, as it ensures each book will pack a punch. Also located in Jersey City, New Jersey, WORD is your ideal neighborhood bookstore. The staff are utterly devoted to their customers, with reasonable prices and a frequent buyer reward program. They love their customers so much, they even have an entire blog devoted to pictures of customers' dogs. Stop by for one of their free events, and get lost checking out their in-home book clubs (there's even a Gilmore Girls one!).
4. Upshur Street Books – Washington, D.C.
Before you wander over to Politics and Prose, Washington D.C.'s most widely known independent bookstore, give Upshur Street Books a try. Barack Obama surely did on Small Business Saturday in 2015! Upshur Street Books is a fairly recent opening in the D.C. area, but customers have been loyal to this business since 2014 for all the right reasons. The store offers a generous variety of books on various topics, but the staff is also selective over orders to ensure you leave with a quality read. Hop on over during the weekend, and you can pair your book shopping with a fresh pastry and a cup of coffee. Maybe you can even buy the same books as the Commander in Chief!
5. Women and Children First – Chicago, Illinois
One of America's most well-known feminist bookstores, Women and Children First holds true to its slogan, "Shop as independently as you think". Women and Children First creates a safe atmosphere for not only women and members of the LGBTQ community, but anyone and everyone. This store is a place for people to gather and share stories and ideas while searching for their next great read. The store carries more than 30,000 books by women, and the staff is more than willing to find whatever you're looking for, even if it's not in the store. Stop by Women and Children First on your way to see the Cloud Gate, and you won't regret it.
6. Malaprop's Bookstore/Cafe – Asheville, North Carolina
If you ever find yourself in downtown Asheville, make sure to give Malaprop's Bookstore/Cafe a try. Malaprop's manages to bring the focus back to the books in its spacious area that feels both exciting and familiar. The owner's goal is to own a place "where the books are the stars", and they succeed by bringing a little spice to book buying. If you're unsure of what to buy on your own, you can head over to the "Blind Date with a Bookseller" section, where books are hand-wrapped with paper to conceal their identity, leaving only a few words of description by the selector. If all of these reasons aren't enough to give Malaprop's Bookstore/Cafe a visit, the fun name in itself should be the final push you need.
7. Left Bank Books – St. Louis, Missouri
Another observer of the indie bookstore cat (Spike is always available for a pat), Left Bank Books is the oldest and largest independent bookseller in St. Louis. Left Bank Books is known in the community for their impeccable customer service. They even have a personal rule, to never point to a book, and to instead walk each customer to the actual location. Left Bank Books also has a fantastic selection of used books in the basement, along with recent publications on the ground floor. Finally, they house over 300 events PER YEAR, so chances are you will wander in on either a poetry reading, author signing, or a book club meeting during your stop.
8. Boulder Bookstore – Boulder, Colorado
Ever dreamed of perusing through THREE STORIES of an independent bookstore? Well, wake up and get on over to Boulder Bookstore in Colorado. This bookstore is simply gorgeous, with large aisles that invite you to sit down on a comfy rug and get lost in a book. Despite the size, Boulder Bookstore manages to be surprisingly intimate, with a strong emphasis on community. The only downside of Boulder Bookstore is the amount of time you will inevitably need to wander, and is that really even a downside? Just be sure not to throw your entire vacation out the window in order to visit each of the 100,000 titles in stock.
9. Garden District Book Shop – New Orleans, Louisiana
As if you really needed another reason to immerse yourself in New Orleans, Garden District Book Shop is just one more excuse for the road trip. Located in a building that used to be an ice skating rink, Garden District Book Shop is packed to the brim with books. Books are nearly overflowing off of the shelves, giving you the feeling of browsing through a friend's bookshelf for your latest read. This bookstore also has a wide variety of regional books, satisfying your curiosity for the rich New Orleans culture. You can even find a signed edition of your favorite book leftover from the author signings that are often held in-house.
10. Inkwood Books – Tampa, Florida
If you're in Tampa, Inkwood Books will inevitably draw your attention due to the fact that it's the sole full-service independent bookseller in the city. Despite this, Inkwood Books is a treasure in itself, remodeled out of an old house and given the breath of life it has today. The store is remarkably quaint, and truly lives up to the idea of "shop local". The store also has a fantastic children's section, with plenty of seats and interesting displays that will keep your children happy while you browse. Stop by Inkwood Books for your latest beach read before heading over to the shore.


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This week the team discuss the impact mobile technology will have on our relationships and use of cars. Discussions quickly move from in-vehicle entertainment to look at ways vehicle data could usefully be provided to drivers even before they get in a car. Options for personalisation are also considered - if cars can access data about our movement and preferences how could they further adapt to our needs?
Special Guest
Special guest Ilicco Elia from (our generous studio hosts) DigitasLBi joins to describe some of the issues and opportunities his team are examining through work with vehicle manufacturers bringing connected vehicles to the market.
The Chat
Ewan says he doesn't just want connected vehicles. He wants his entire access to a car (and all it's maintenance and fuelling) to be mediated by a mobile app-type experience. He has recently failed to buy a Volvo.
Rafe says it's a long time until the future. And that the lifetime of vehicles means any transition to connected - or even remotely managed - cars is some way off.
Ben says he doesn't understand how current options on even expensive cars are so poor. He envies the facilities offered to buyers of new electric vehicles to monitor status and setup via smartphones.
The Survey
Tell us what you think - we'll report the results in a future episode. If you want to say more, drop us a comment!


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New Documentary To Make A Farm Premieres at the Vancouver International Film Festival
The new documentary To Make A Farm by filmmaker Steve Suderman is premiering at the Vancouver International Film Festival on October 7th and 8th. You can find details and see clips at http://tomakeafarm.ca/.
The documentary follows several new farmers, including Jeff Boesch and Leslie Moskovits from Cedar Down Farm and Tarrah Young and Nathan Carey from Green Being Farm, whom all farm outside of Neustadt in Grey County. We're pretty sure that you'll find these four farmers as inspiring as we do here at FarmStart, so make sure to keep an eye out for this film! (You have likely already met these farmers, leading a workshop or course for FarmStart.)
"Starting a farm from scratch takes more than just imagination, but it's a good place to start. Often considered a way of life from the past, today there is a movement of young people without farming backgrounds taking up this challenging profession. To Make A Farm follows the lives of five such young people through their first seasons on the land, as the joys and disappointments of bringing life from the earth become a quiet manifesto for social change. Documentary filmmaker Steve Suderman searches his own family history in farming to wonder if the mistakes of the past can be avoided this time through."
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Why go
Tobacco Free?
Healthcare services worldwide play a vital role in proactively addressing the tobacco epidemic in order to protect population health. So, if your healthcare service wants to get involved, this is a great place to start…
What are the Global Standards?
Reviewed in 2015, these evidence-based standards address key elements known to be important in achieving outcomes for tobacco management and tobacco cessation within healthcare services. Together with a process of self-audit, they support sustained commitment and continuous improvement.
Why participate in the GOLD Forum Process?
The GOLD Forum recognises healthcare services working at the highest level of implementation of tobacco control in accordance with the Global Standards. In addition to recognition, the GOLD Forum provides a learning and sharing opportunity for the exchange of good practice.
General Assembly 2018
AND Swiss Autumn Workshop
13th and 14th September 2018 in
Town Biel Switzerland
Other events
18th Annual Conference of the SRNT Europe
6-9 September 2018, Munich Germany
The International Society For The Prevention Of Tobacco Induced Diseases (ISPTID) – 14th Annual Conference
WHEN: 4-6 October 2018
LOCATION: Izmir, Turkey (Ege University Ataturk Cultural Center)
CALL FOR ABSTRACTS: Close 24 May 2018
ICO-WHO Symposium on Tobacco Control
The 4th ICO-WHO Symposium will focus on bridging the gap between research and policies in tobacco control
More information to come.
For more tobacco related events visit the 'Events Calendar' on the website.
Member activities
Target 2025: VNSHS signed up!
In an effort to 'virtually eliminate' smoking in Victoria, 24 organisations (including the Victorian Network of Smokefree Healthcare Services - VNSHS) have signed on with great enthusiasm to Target 2025 - which aims to reduce the daily smoking prevalence to 5% by 2025.
Achieving a target of 5% in 2025 would effectively mean halving the number of Victorians who currently smoke (prevalence of adults smoking daily was 13.7% in 2014-15) and a total saving of $4.0 billion in tangible costs - including over $602 million in healthcare costs!
View the video made by staff at Hospital Sierallana (Torrelavega) especially for this year's World No Tobacco Day!
This year two healthcare service members of the Swiss network share their activities on how they engaged staff about the effects of smoking for World No Tobacco Day.
This year for World No Tobacco Day (31 May), the Tobacco Free Ireland partners came together to mobilise and empower community action at a conference at Farmleigh. The event supported the drive towards achieving the government's Tobacco Free Ireland 2025 goal of less than 5% smoking prevalence in Ireland.
Other news
New report (26 June 2018) released by the Royal College of Physicians calls for radical change for smoking cessation within the NHS system. Key recommendations include identification of smokers, delivery of smoking cessation support and training to be incorporated as a systematic and component of all NHS services.
On 28 June 2018, the World Trade Organization (WTO) released the panel report on the challenges to Australia's tobacco plain packaging laws. The panel found in favour of Australia, dismissing the claims brought by Cuba, the Dominican Republic, Honduras, and Indonesia.
March 2018 UK National Centre for Smoking Cessation and Training (NCSCT) publication on how to accompany smoking policies in mental health services with appropriate nicotine dependency treatment pathways, staff education, pharmacotherapy (including short acting formulations) and behavioural support options.
People have died from tobacco-related diseases since the opening of the first FCTC working group on 28 October 1999
The Death Clock keeps a running tally of how many people have died from tobacco related diseases since 28 October 1999. That's the date of the first meeting of the working group on the future World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC)..
One of the largest comprehensive regional health services in Australia.
With consumers at the forefront, Barwon Health's mission is to excel in delivering efficient integrated care, education and research to advance health and wellbeing for all.
Together with our community we build healthier lives, inspired by world class standards.


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Eoin Campbell (c)
This weekend we will pay a visit to the annual Kings of Concrete Festival which was fantastic last year. Held on the grounds of the Civic Offices (Dublin City Council) there is a whole lot going on over the course of the weekend, but we will meet at our usual time of 2pm, Sunday at the entrance nearest to Dame Street (on the start of Fishamble Street) just before Christchurch Cathedral and opposite the Bull and Castle pub.
Last year there was great weather so we were lucky, but if the weather is bad, then there is the Bull and Castle to keep you warm, watered and fed if needed!
All meet together again at 4pm at the same entrance and head for the Bull and Castle for coffees etc.
I'm off to Cork this weekend so I won't be out myself and the following weekend is the Plein Air Festival in Wexford, which I am really looking forward to. There are a few Dublin Sketchers heading down again this year but if anyone is interested in coming with us - it really is a great weekend of painting :-) Can't wait! http://www.artintheopen.org/ for more info.
Enjoy Sunday - remember to send us in photos of your work so we can put them on the website!


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Encourage And Teach Entrepreneurship To Kids Workshop
I have been an entrepreneur most of my adult life. I love the profession. I believe we should be teaching our kids about this great profession as early as the first grade.
Cameron Herold, also a successful entrepreneur and MIT professor, did this Ted Talk which has over 1.5 million views about why he thinks kids should be encourage about entrepreneurship. Click here to listen to the Ted Talk.
This course is about encouraging your kids to make and save money.
I define a "kid entrepreneur" as a young person who: makes money, saves money, and can handle all the responsibilities of school, family, and friends. A kid entrepreneur is different from an adult entrepreneur.
There is a very strong possibility that someday your child will become an entrepreneur. Over 50% of Americans have either started a business or have wanted to start a business by the time they reach 50 years old.
Learning entrepreneurial skills early will help your child in the future become a successful entrepreneur, leader and will help build self-esteem and confidence.
Schools are not teaching entrepreneurship, mostly because they don't know how. But, I do. I produced these 10 easy to follow lessons that will guide you to becoming an entrepreneur coach for your kids. Each whiteboard lesson is between 7 and 15 minutes. Notes are included with each lesson. Most of the lessons have homework, which are activities for you and your child to do together.
Making and saving money builds self-esteem and confidence in your child like nothing else can!
Encouraging and teaching your kids about entrepreneurship
This 10 part course is about encouraging you to start learning this amazing profession today. This course is for kids, parents, teachers, relatives, coaches, senior citizens and ministers. This course is for everyone. Feel free to take the lessons in any order.
Introduction to the course
1. Benefits of learning Entrepreneurship early
2. What is an entrepreneur?
3. Entrepreneurship by the numbers
4. Teach, encourage dreaming, goal setting
5. Different types of kids
6. 5 Qualities of great leaders
7. Things kids can do to make money
8. Reinforce your child
9. Money goal setting
10. Wrap up, review and more
These videos are designed to help give you and your child some ideas on what they can do to make money.
1. Kids jobs 10 fun easy job ideas for kids
2. Kids Jobs Become A Outdoor Vendor
3. Kids Jobs Become An Umbrella PEDDLER
4. Kids Jobs Becoming A Designer
5. Kids Jobs Making And Selling Pizza
6. Kids Jobs Omars Trash And Lawn Service


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PEEKSKILL, N.Y. -- Peekskill Police are looking for two men who tried to lure a 13-year-old boy into a van Thursday night.
The teenager told police that as he was walking on Spring Street, a man in his 40s or 50s exited the passenger side of the white van with black bumpers and tinted windows, and asked him if he wanted a ride home, police said.
A man in his 20s then exited the driver side of the vehicle and said, "Come on, I have candy," police said.
The teenager then turned and ran north on Spring Street, fleeing the area, police said.
The passenger had dark bushy hair, was clean shaven, wearing a brown colored "Polo" brand shirt and blue jeans, red colored Nike "Hyper Dunk" sneakers, with a Spider tattoo on the left hand and wearing a blue colored charm bracelet on the right wrist, police said.
The driver had a medium build, dark colored short cropped hair, tattoos covering both arms from shoulders to the wrists, tattoos covering the neck, wearing blue colored Nike basketball shorts, a white colored tank top and having a nose ring in the right nostril, police said.
Anyone with any information is asked to contact the Peekskill Police Department at 914-737-8000.
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|The Pentrals by Crystal Mack, pub. November 2013, 246 pg.
Antares follows people for a living. Her job is to track one person's movements. She has to monitor them as closely as possible, and there are drastic consequences if she strays from her job.
No, Antares is not a spy or secret operative of some government organization. Instead, the main character of The Pentrals by Crystal Mack is something much more common – a shadow.
Antares is the Shadow assigned to Violet, a teenage girl living in the opulent, mirrored city of Talline. She is a Class Two Pentral, or a Shadow or Reflection assigned to mirror the movements of a living creature. She doesn't feel emotions, and her only form of interaction is the brief moments she crosses paths with other Shadows and can exchange thoughts.
After tragedy strikes Violet's group of friends, Antares begins to notice drastic changes in her Person. Violet becomes withdrawn and starts taking Lift! – a drug that makes it impossible for Antares to remember anything that happens afterwards.
Eventually, Antares has enough of Violet's changed attitude and suddenly is filled with a blinding rage and tries to rip away from her Person. Violet falls and collides with the Shadow, and, after briefly losing consciousness, Antares wakes up in Violet's body. Suddenly able to openly communicate, emote, and move freely for the first time, Antares comes face to face with a city-wide conspiracy and has to expose the truth before it is too late.
To say this book is unique would be an understatement. As soon as I realized the story was told from the point of view of a Shadow, I realized it was going to be unlike anything else I'd ever read. And I was right.
The futuristic setting is just one of the many appealing aspects of this book. In Talline, paper and ink are almost never used. Instead, everyone has Holopanes – tablet-like devices that are used to communicate, record events, browse databases, and do pretty much anything anyone could ever need. Instead of cars, citizens of Talline travel in self-driven carpods. Their technology is incredibly advanced, and it progresses even more throughout the course of the book.
The Pentrals handles a lot of topics that we all see daily. Body image and trying to understand what real love is are just two of the recurring themes. When Antares wakes up in Violet's body, she realizes that her Reflection is hideous and monster-like, and, even though it looks nothing like Violet's true appearance, she begins to believe that she really is ugly and unworthy of attention.
This book has a very unique love triangle. Because Antares spends some time inhabiting Violet's body, everyone thinks she is Violet, including Violet's boyfriend. However, Antares starts to have feelings for another boy and has to figure out how to cope with them without ruining Violet's life.
One of Antares's main struggles throughout the book is balancing what she thinks is right with what she thinks the real Violet would do in many of the situations. She occasionally communicates with Shadow Violet, but often she has to decide what the best course of action is on her own. Antares truly cares about Violet and doesn't want to change her relationships, so she faces the challenge of weighing what she feels is right against what Violet would actually do.
Although it took me a little while to get into this book, once Antares's complicated background was explained and the plot began picking up pace, I couldn't put it down. As the story progresses, author Mack throws more and more balls into the air for her characters which makes the story even more gripping. As more challenges are placed in front of Antares, Violet, and their friends, it becomes even more interesting to see how things will turn out.
This book really brought out my inner sci-fi nerd. The Pentrals in their many forms are almost-but-not-quite-human creatures with unique personalities. Seeing how their lives intertwined with those of the people they are assigned to was one of my favorite aspects of this book. Even though it took a bit for the story to really get going, I think The Pentrals should definitely be on the must-read list of anyone who enjoys the sci-fi and fantasy genres.


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I quite liked Bernard Porter's suggestion in the London Review of Books that MPs should be removed from the Palace of Westminster during its impending refurbishment. But not for the reason he gave. To suggest that it is only by relocating parliament that "they would see the shuttered-up shops, the desolation caused by deindustrialisation, as well as the many positive and promising aspects of provincial life" is to miss – probably deliberately – a fundamental point about the nature of our politics. Take a look at some of the more progressive moments in our parliamentary history. Maybe they had to drag Disraeli around the Potteries in order to pilot the Reform Act of 1867 but I can't be sure. My A Level History finished in 1860.
The MPs that meet in the House of Commons are representatives of constituencies. Even if you despair of the world's foolishness, as Porter appears to, you have to appreciate that the people who actually sit in the Commons DO spend some time in the places that they represent. Indeed, as we found out during the expenses scandal, it is something our politicians do all too well. Now you may not agree with the policies they produce but it is not simply a case of them being oblivious. It's not the physical proximity of the political class which makes them out of touch with the voters, but their ideas. Porter's suggestion does have something to it though.
The recent debate in the House of Lords called by Dame Betty Boothroyd is revealing. The prompt to the debate was UNESCO's threat to withdraw World Heritage site status to the Palace of Westminster because of tall development's at the Shell site and the adjacent Elizabeth House. Where you might imagine that there would be some discussion of how a city balances its need to move forward with its need to conserve the past, the discussion though shows how incapable parliamentarians – admittedly the old pointless ones – are of addressing this and quickly return to a discussion of the parliament's status as a monument.
The Lords main response is to consider the UNESCO comments within the context of the impending refurbishment to the Palace of Westminster. §In one way it is understandable, after all the early cost estimates suggest it will cost £3 BILLION to get parliament up to scratch, although An independent assessment of options is being undertaken currently by a consortium led by Deloitte Real Estate and including AECOM and HOK. But perhaps understandably given that they are old relics too, the talk turns mainly to the status and the history of the parliament building itself. Lord Dobbs made liberal use of quotations about the destruction of the previous building from a popular history by Caroline Shelton, The Day Parliament Burned Down. Shelton is herself is head archivist at the parliament. The discussion shows people trying to merge their role and their status with the physical structure of a building.
This strange fetishisation of the parliament as a monument is more than just an accidental quality of a single debate. It was telling that last year it was announced that the statues of former prime ministers that stand in the House of Commons, the lower house of the British parliament would need to be protected from members of Parliament who touch them for luck, particularly an effigy of Winston Churchill which has been rubbed away at the knee by tribute-paying fortune-seeking Tories. This obsession with the material qualities of the parliament-as-monument is likely to increase over the coming years due to the renovation.
We will also hear more about the story of the parliament's origins as we move into the refurbishment phase. In addition historians are turning to the relatively unknown story of its chief architect Charles Barry. Shenton herself is writing a book which tells his story particularly in relationship to his role as chief architect of the parliament. And yet we must consider that whilst the structure itself is being refurbished this is not the same as the institution itself being addressed.
Porter's suggestion for an itinerant parliament makes us wonder: is a monument the best place for a parliament? The debate in the Lords shows how individuals within an institution can use their relationship with a monument to dispense with their individual agency to address the reality of our built environment: to discuss the competing demands on our city. When Cedric Price made his quick design for a Pop-Up parliament – the first time, I have found the term "Pop-up" being used in relation to architecture – he was clearly addressing this feature. He wrote at the time: "if we want an efficient parliament, let's give it a whole efficient building to work . . . replace the present historic monument with an up-to-date structure – flexible, accessible and dispensable."
It is an intoxicating argument. However, – let's be honest – it is extremely unlikely. We are too attached to the Palace of Westminster to ever conceive of moving our democratic institutions from it, let alone replacing it. Still, I believe that it might be beneficial for parliamentarians to forget the physical structure of the place and consider its achievements in an abstract but ultimately more enduring way – universal suffrage, representative democracy – rather than events that have been enshrined in the material fabric of a structure.


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Thursday on MSNBC, Rep. Maxine Waters (D-CA) said she believed there are "connections" between President Donald Trump and Russia which will cause him to be "eligible for impeachment."
Waters said, "I've always said that I believe if we get the investigations that need to be done if we drill down, we're going to see the connections. We're going to understand the role that this administration has played during the campaign with Russia. and when we see that, he certainly will be eligible for impeachment. I do believe that."
She continued, "I'm not satisfied yet. I'm worried about the Republicans who are still standing up for Trump, even in the face of growing information. So I still think the call for an independent commission is credible and that we should do that. Let's see what happens. They're going to do the investigations and I want the Democrats to be poised with all kinds of research and information to do the drilling down that I think is necessary to understand what Trump has done in connection with the Russians to undermine our democracy."
She added, "I am saying the investigations must be done, the drilling down must be done. We must get to the facts of what it has been about. I don't think you can do the impeachment just because I think or others think. But I think if we do the investigations, that we will find the connections and I do think that impeachment will be necessary."
Follow Pam Key on Twitter @pamkeyNEN


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A distinctive addition to any collection, and very exclusive with the mintage restricted to a mere 2,500, this vibrant release is beautifully presented in an elegant, glossy black case.
- Coin Highlights:
- Stunning poppy-shaped colour coin
- Struck from 1oz of 99.9% pure silver
- Smartminting technology
- Official Cook Islands legal tender
Product Code: 16630
Metal Content (Troy oz) 1
Monetary Denomination (Cook Is.) $5
Fineness (% purity) 99.9
Diameter (mm) 45.00
Maximum Mintage: 2500


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Following the election, family planning centers in Wyoming say they saw a sharp increase in women seeking long-term contraceptives. But that surge has not been accompanied by increased funding for the cash-strapped clinics.
Nationwide, donations have poured into reproductive health organizations like Planned Parenthood, but in Wyoming, there is only one Planned Parenthood clinic, in Casper.
In the rest of the state, the Wyoming Health Council oversees the funding for nine family planning centers under Title X, a federal law that funds health services to low-income people. Council Executive Director Susie Markus said the clinics' budgets can be tight, making it difficult to handle a surge in demand for expensive long-acting contraceptives like IUDs and implants.
"When they hear that access to reproductive health care and birth control that are publicly supported might be at risk, then they are more likely to want to try and get that now and have it last," said Markus.
But Markus is hoping to raise additional funds to help cover the recent surge in demand. Some clinics in the state have seen a slight uptick in donations in recent days.
"So it was very exciting, because I didn't expect it," said Markus. "So, yesterday we started getting emails from our PayPal account, that donations were coming in. But they weren't from Wyoming, they were from across the country."
Markus said because federal funding is not available to clinics that offer abortions, Wyoming's family planning clinics do not provide that service. Markus said they do, however, provide preventative care, like breast exams and cancer screenings.


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I am a passionate science communicator and have recently started two science outreach initiatives: Science in the Pub Adelaide and Science in the Pub Tasmania in Adelaide, South Australia and Hobart, Tasmania, respectively.
The principal goals of SciPub are to make science engaging, accessible and accountable to the public, and to enhance the ability of people with only a basic understanding of science to critically evaluate scientific data. SciPub events are held from 6-7:30 pm in a pub to foster a relaxed, congenial atmosphere for scientists and non-scientists to learn, discuss and think critically about hot topics in science.
Each monthly SciPub event features three panellists from varied backgrounds that all research a central topic. Each panellist delivers a 10-12 minute presentation related to the topic for the evening. In order to help non-scientists improve their ability to evaluate scientific evidence we ask that each panellist include at least one data slide in their presentation, and that the panellist provides an explanation about how the data were acquired and how they interpret the data. Following the short presentations the panellist then respond to questions from the audience via a moderator.
We attempt to select panellists who are not only enthusiastic and knowledgeable about a topic but are known as engaging science communicators. We have been floored by the positive feedback we have received from the community in response to this initiative. We plan to keep it up as long as we have topics and panellists at our disposal (which, in Hobart, will be for a long time!).


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n his research to identify what can make a company truly great for the long term, Jim Collins (2005) found an essential personal quality of senior executives that took his research team by surprise: humility combined with intense professional will. All the companies his research identified that made the leap to being truly great companies over a long period of time had a senior executive that exhibited these qualities. These executives were not particularly charismatic, stayed out of the public eye, and rarely boasted about their own professional accomplishments. Each guided his or her company through tough times, helped foster a sustainable organizational culture, and left his or her company with effective managers capable of sustaining success.
For this final Discussion, review the Learning Resources and think about your own professional experiences to identify the management practices that contribute to sustainable organizational culture. Also, reflect on the management practices you have observed or employed that create and sustain a positive and profitable work environment as you prepare for the discussion post below.
With these thoughts in mind:
By Day 5
Post an explanation of the direct and indirect contributions managers make to create a sustainable organizational culture. In your explanation, select and describe three management practices—from the resources or your professional experience—that you consider to be essential for contributing to a sustainable organizational culture.
Hint: Your answer needs to take into account that creating a sustainable organization culture is not an easy task—the direct and indirect contributions may require the managers make difficult choices that impact employees in different ways.
Click here to order this paper @Superbwriters.com. The Ultimate Custom Paper Writing Service


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We know that you can purchase our books from other sources and believe that treating customers right is the one thing that separates us from everyone else. Our office and warehouse is staffed Monday through Friday, 9am to 5pm Eastern Standard Time. On evenings and weekends, we can be reached via email.
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Transhair Europe
In 1989, Transhair started performing hair transplantations. At the time, the use of the hole-punch method was still one of the most popular methods. Five to eight treatments were necessary to achieve a reasonable result. This was one of the reasons for Transhair to scrutinise the limitations of the treatment and to look for a better solution. It had to be possible to cut and implant more and smaller follicular units/ grafts (hair transplant consisting of one or more hairs) within the same time frame. The demand for this solution appeared to be so large that over a period of three years Transhair quickly had five clinics in Germany and the Netherlands. Transhair, now located in Vlijmen and with clinics throughout the Netherlands and Germany, is one of the largest hair transplantation clinics in the world.
Our hair surgeons authorities in the field of hair surgery. They have more than six thousand treatments under their belts and perform six hundred treatments at Transhair Netherlands each year. The Transhair clinics in Germany and the Netherlands have already performed more than 30,000 successful treatments.
See our clinic
Quality is no coincidence in our clinic. We want to ensure our clients of excellent quality. Not only to meet the expectations of the client, but to exceed them. In addition, we realise that such expectations statements are subject to constant change. What is new today and is progressive, is old news tomorrow and outdated. Along with the endorsements that Transhair has achieved, we will give you the assurance that you are in safe and expert hands.
Practice makes perfect
What makes Transhair unique is the approach: a complete team of our specialists works simultaneously on a single hair transplantation. They exchange information and insights that contribute towards guaranteeing an optimum result. Above all, this helps them to accrue an enormous amount of knowledge and experience because, through the regular execution of a procedure, they can increasingly improve their skills. 'Practice makes perfect'. A saying that is borne out by Transhair.


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Working on +30 Master of Education - Specialization: Literacy
Master of Arts in Teaching, Content: Secondary English, Coastal Carolina University
Bachelor of Arts in English, Minor in Business Administration, Coastal Carolina University
AP Language and Composition, College of Charleston
Gifted and Talented, Charleston Southern University
Dear GHS Students,
Because English/Language Arts is a demanding course, it is important that you come to class everyday prepared and ready-to-go without interruption. I have extremely high expectations of all of my students, and I expect nothing less.
Our focus will be on grit, perseverance, and rigor. I want to challenge you to go beyond your comfort zone, to build your strength of character, to improve your listening and speaking skills, and to encourage you to become a life-long reader, writer, and learner.
Your engagement is vital; it will be an investment of your personal time, energy, and interests. Your success ultimately depends on you.
I am available to help you in every way.
"The mission of Georgetown High School, in cooperation with the home and community, is to provide educational opportunities for life long learning and for ethical, productive participation in a democratic society and the global community."
Copyright © 2018 Georgetown High School


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Perceptual Motion
Perceptual Motion, Inc. (Chicago, IL) is a dynamic intergenerational modern dance company directed by award-winning choreographer Lin Shook. Its mission is to transform the abstract imagery of dance into personal and meaningful experiences. PMI has performed at Ruth Page, Hamlin Park Theatre, Harold Washington Library, in Dance Chicago, The Coyote Festival, Millennium Park. It provides dance residencies, after-school programs and classes for people over 40.
Harvard Vallance studied with Shirley Mordine, Nana Shineflug, Joel Hall, and Victor Clottey. He founded The Kalamazoo African Dance Company, introducing West African dance and hip-hop to thousands throughout Southwestern Michigan. Lin and Harvard have collaborated since 2006. www.perceptualmotiondance.com


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Moving Sale! Save 15% Off 10lbs+ Each Variety!
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Same body at the FreshRoast SR300. The difference is the SR500 gives you more control of the roast.
by John on August 10, 2014
I have been "home" roasting for more than 10 years. I have never been disappointed by any product from Coffee Bean Corral. This includes the roasters. If you are considering home roasting, I strongly recommend this roaster. When you combine the fabulous information from the coffee bean matrix to your taste and you roast the coffee bean to your desired color. It's magic...
by Anonymous on January 2, 2011
Wonderful home roasting system! First roaster purchase for me. I was able to watch the roast, make adjustments with the variable speed fan and temperature selector. When I roast I run it on low temp and high fan for a minute, then cool for a minute. I do ths twice. It starts a nice even roast. I read about this online. Then I run it on a full cycle with a lower fan speed and wait on first crack. If I don't get anything, I up the temp to the middle setting. All beans are not created equal. I heard first crack loud and clear. 2nd crack sounds lower and comes in at different times depending upon the specific bean (almost right away or 2 minutes later). I've used it 5 times and its a breeze. Easy to clean too. I'd highly recommend it to anybody new to home roasting. Get the 500, not the 300. It costs a little more but the control it gives you is well worth it. The coffee was magnificent!
by Anonymous on December 17, 2016
I'm delighted, too, by the Fresh Roast 500, which has given great roasts without fail for more than two years. The first big plus is that the unit fits nicely under my stove's range hood, which in my case is 13 1/2" above the stove top. With the fan on high I can roast up to medium-dark color indoors year-round without smoking up the kitchen.
I start each roast at low heat, running the fan at full speed for about 4-5 minutes until the beans are rolling about evenly on the air bed. Next I move the heat up to medium and slightly reduce the fan speed for another 4 minutes or so. At that point the beans are beginning to brown nicely. Then, I turn down the fan to listen for the first crack, which starts almost immediately, then throw the fan into cooling mode at the start of the second crack (or sooner or later when tweaking roasts) to see what other flavors I can draw out of the bean.
To me, it's the ease of monitoring the roast by sight, aroma, and color that really makes this roaster a winner. In fact, even for someone looking to eventually move up to a larger roaster, I would recommend buying and keeping the Fresh Roast 500 as a sample roaster.
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After the visit to the Brahma Temple you can go to the ghats, where, most probably, a local guy will be waiting for you, and offer you a ritual. He will insist the ritual is free, then he will give you a tray with flowers and a bracelet.
♥ Visit Tagulandang Island ♥