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Project 1: Adenosine Deaminase Deficiency Genetic deficiency of adenosine deaminase (ADA) can result in severe T, B and NK cell lymphopenia, but also non-immunological abnormalities of the skeleton, liver, lungs, kidney and central nervous system. We follow a cohort of 40 ADA-deficient patients in whom we have recently noted additional remarkable hematologic features that include neutropenia and dysplastic changes in peripheral blood and bone marrow examinations. These findings are associated to prolonged marrow suppression after low-dose chemotherapy and I.V. antibiotic-induced neutropenia (Sokolic R., Maric I., Kesserwan C., Garabedian E., Hanson C.I., Dodds M., Buckley R., Issekutz A., Kamani N., Shaw K., Tan B., Bali P., Hershfield M.S., Kohn D.B., Wayne A.S., Candotti F.: Myeloid dysplasia and bone marrow hypocellularity in adenosine deaminase-deficient severe combined immune deficiency. Blood 2011;118:2688-94). We hypothesize that these myelodysplastic features underline a yet unrecognized hematopoietic stem cell defect due to ADA deficiency. To test this hypothesis, we will take advantage of the available Ada KO mice and perform in vitro (CFUs) and in vivo (competitive repopulation assays) analysis of stem/progenitor cell potential. We will also assess whether ADA deficiency results in hematopoietic defects in developing zebrafish. We have also observed a high prevalence of dermatofibrosarcoma protuberans (DFSP) among our ADA-SCID patients (Kesserwan C., Sokolic R., Cowen E.W., Garabedian E.K., Heselmeyer-Haddad K., Lee C.R., Pittaluga S., Ortiz C., Baird K., Lopez-Terrada D., Bridge J.A., Wayne A.S., Candotti F.: Multicentric dermatofibrosarcoma protuberans in patients with adenosine deaminase-deficient severe combined immune deficiency. J Allergy Clin Immunol 2012;129:762-9). DFSP accounts for 0.1% of all cancers and only about 180 pediatric cases have been reported. The striking association between two rare conditions suggests the possibility of a shared cause. Because adenosine plays an important role in the development of fibrosis and ADA deficiency predisposes to increased susceptibility to DNA strand breaks, we postulate that the combination of the fibrogenic milieu induced by increased adenosine levels and the intrinsic genomic instability of ADA-deficient cells may be responsible for the high risk of DFSP. To test this hypothesis, we will assess the rate of gross chromosomal rearrangement and analyze chromosomal segregation in S. cerevisiae deleted of AAH1, the yeast homolog of the human ADA gene. In addition, we will to assess genomic instability in primary lymphocytes and lymphoblastoid cell lines from ADA-deficient patients by measuring their sensitivity to radiation and methyl methanesulfonate (MMS) treatment. The natural history of multicentric DFSP in ADA-SCID patients is unclear and presents significant clinical management challenges. We will monitor the natural history of these unusual tumors through a combination of conservative surgical approach, close observation and experimental evaluation of topical administration of receptor tyrosine kinase inhibitors. Project 2: Wiskott-Aldrich Syndrome (WAS) WAS is a rare X-linked disorder caused by mutations of the WAS gene and presenting with life-threatening hemorrhages, infections, autoimmunity and cancer. For yet unclear resons, WAS patients shoe high frequency of spontaneous reversion events. We have recently shown that the general mutation rate is not increased in WAS compared to controls (Davis B.R., Yan Q., Bui J.H., Felix K., Moratto D., Muul L.M., Prokopishyn N.L., Blaese R.M., Candotti F.: Somatic Mosaicism in the Wiskott-Aldrich Syndrome: Molecular and Functional Characterization of Genotypic Revertants. Clin Immunol 2010;135:72-83). Autoimmune disorders are diagnosed in 40-70% of WAS patients and complicate post-HSC transplant outcome in >20% of cases. We and others have characterized the CD4+CD25+FOXP3+ natural regulatory T cells (nTregs) in Was KO mice and WAS patients and shown abnormal capabilities of WAS nTreg to suppress T and B cell proliferation, which may contribute to autoimmunity (Adriani M., Jones K.A., Uchiyama T., Kirby M., Silvin C., Anderson S., Candotti F.: Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells. Blood 2001;117:6608-11). A level of complexity is added by the existence of a second group of Treg cells that are induced in the periphery (iTreg) in the appropriate cytokine milieu (IL-2+TGF-b). We hypothesize that the iTreg cell function may be affected in WAS. To test this hypothesis, Was KO iTreg cells will be generated and tested in T and B cell suppression assays. In vivo studies will also be conducted to evaluate the capability of Was KO iTreg to prevent the lethal autoimmune syndrome in Scurfy mice. Was KO mice are susceptible to autoimmune disorders, such as inflammatory bowel disease, IgA nephropathy and production of antinuclear antibodies (Shimizu M., Nikolov N.P., Ueno K., Ohta K., Siegel R.M., Yachie A., Candotti F.: Development of IgA nephropathy-like glomerulonephritis associated with Wiskott-Aldrich syndrome protein deficiency. Clin Immunol 2012;142:160-6). These features will allow testing pharmacological intervention aiming at altering the equilibrium between immune suppressing Treg cells and pro-inflammatory Th17 cells as a potential therapeutic option. In addition to experiments in mice, we will characterize the suppression defect of WAS nTregs on B lymphocyte proliferation and the ability of generating functional iTreg using T cells isolated from WAS research subjects with different clinical presentations in terms of autoimmune complications and presence or absence of auto-antibodies. Project 3: Reticular Dysgenesis (RD) RD represents less than 3% of all SCID and is characterized by profound neutropenia and severe T-cell lymphopenia. Affected newborns often show sensorineural deafness. We have recently shown that RD is caused by mutations of the adenylate kinase-2 (AK2) gene (Lagresle-Peyrou C., Six E.M., Picard C., Rieux-Laucat F., Michel V., Ditadi A., Demerens-de Chappedelaine C., Morillon E., Valensi F., Simon-Stoos K.L., Mullikin J.C., Noroski L.M., Besse C., Wulffraat N.M., Ferster A., Abecasis M.M., Calvo F., Petit C., Candotti F., Abel L., Fischer A., Cavazzana-Calvo M.: Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nat Genet 2009;41:106-11). AK2 is expressed in the mitochondrial intermembrane space in a variety of tissues such as the liver, kidney, spleen and heart, where it regulates the homeostasis of cellular adenine nucleotides by converting ADP into ATP+AMP. The molecular mechanisms responsible for the biological defects of the disease remain unclear. We set out to develop mouse and zebrafis models of the disease. Ak2 conditionally targeted mice will be generated and crossed to Cre deleter strains, such as Lck-Cre, CD19-Cre, Lyz2-Cre, Mx-Cre, CMV-Cre. Resulting animals will be characterized for development and function of the myeloid and lymphoid compartments. We are also generating zebrafish models, including Ak2 knockdown morphants and Ak2 mutant fish. The latter will also be recovered from an ENU-mutagenized zebrafish library that contains an Ak2 missense mutation with predicted severe functional effects and by using zinc finger nuclease-mediated gene targeting. We will also generate induced pluripotent stem (iPS) cells starting from skin biopsies of RD patients. RD iPS will be differentiated into hematopoietic progenitors and mature T, B, NK and myeloid cells. The results from these experiments will characterize the hematological differentiation steps that are affected by AK2 deficiency and provide a framework for preclinical studies of AK2 gene correction.
|Simon, Karen L; Anderson, Stacie M; Garabedian, Elizabeth K et al. (2014) Molecular and phenotypic abnormalities of B lymphocytes in patients with Wiskott-Aldrich syndrome. J Allergy Clin Immunol 133:896-9.e4
|Wilson, Michael R; Naccache, Samia N; Samayoa, Erik et al. (2014) Actionable diagnosis of neuroleptospirosis by next-generation sequencing. N Engl J Med 370:2408-17
|Sadhukhan, Sanjoy; Sarkar, Koustav; Taylor, Matthew et al. (2014) Nuclear role of WASp in gene transcription is uncoupled from its ARP2/3-dependent cytoplasmic role in actin polymerization. J Immunol 193:150-60
|Sood, Raman; Carrington, Blake; Bishop, Kevin et al. (2013) Efficient methods for targeted mutagenesis in zebrafish using zinc-finger nucleases: data from targeting of nine genes using CompoZr or CoDA ZFNs. PLoS One 8:e57239
|Oh, Julia; Freeman, Alexandra F; NISC Comparative Sequencing Program et al. (2013) The altered landscape of the human skin microbiome in patients with primary immunodeficiencies. Genome Res 23:2103-14
|Prislovsky, Amanda; Zeng, Xueying; Sokolic, Robert A et al. (2013) Platelets from WAS patients show an increased susceptibility to ex vivo phagocytosis. Platelets 24:288-96
|Barber, John S; Yokomizo, Lauren K; Sheikh, Virginia et al. (2013) Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases. Proc Natl Acad Sci U S A 110:8164-9
|Lawrence, Monica G; Barber, John S; Sokolic, Robert A et al. (2013) Elevated IgE and atopy in patients treated for early-onset ADA-SCID. J Allergy Clin Immunol 132:1444-6
|Shimizu, Masaki; Kanegane, Hirokazu; Wada, Taizo et al. (2013) Aberrant glycosylation of IgA in Wiskott-Aldrich syndrome and X-linked thrombocytopenia. J Allergy Clin Immunol 131:587-90.e1-3
|Horino, Satoshi; Uchiyama, Toru; So, Takanori et al. (2013) Gene Therapy Model of X-linked Severe Combined Immunodeficiency Using a Modified Foamy Virus Vector. PLoS One 8:e71594
Showing the most recent 10 out of 22 publications


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7 Signs You're an Employedpreneur
I've been meeting more and more people like myself who are holding down a 9 to 5 and building a business on the side. I like to call us "employedpreneurs" and have compiled a short list of the ties that bind us together. Being an employedpreneuer ain't easy on our minds, bodies, or lifestyles but we do it because we want something more meaningful, that makes sense, and that is owned and embraced by our natural abilities.
1. You work full time for someone else and are building your own business after work and on the weekends. You've been in the workforce for a little while and am now working on an exit strategy that supports your dream to work for yourself and doing something that you genuinely care about.
2. You feel a sense of relief when you meet someone who tells you they too work full-time and have a side hustle. It feels good to know there are other people in the world who get and understand it. All of it.
3. At least once a day, you find yourself thinking, "this is temporary." Because it is. We know we will not live the "workforce" life forever and we have an addiction to coffee (or tea), sleepless nights, can't talk too much last night's episode, never ending to-do list, and notebooks filled with thoughts to prove it.
4. You keep your entrepreneur business on the low at work. Unless you are doing the exact same work as your full-time employer for the same customers, there is no conflict of interest and so you don't feel obligated to share your outside activities with your employer or co-workers.
5. When sitting in meetings at the full-time that have absolutely nothing to do with you, you find yourself thinking about and writing down the 100 other things you could be and need to be doing for your own business. Some call it boredom but employedpreneuers refer to it as time management.
6. You step out during the day to take and make calls all while trying to be discreet – mostly around the lunch hour. You strategically set up calls during your lunch hour because employedpreneurs maximize any and all free time. (I think most of our efforts are built around time-management).
7. You are sometimes amazed at how hard you grind and "work" but you understand that it's necessary. Others don't get it. You have a job that pays well, why this too? Employedpreneurs know that there is more to our lives than just having a job that pays well. We want to be responsible for creating a life on our own terms and for having a direct impact on others.
I believe the saying is "the dream is free but the hustle is sold separately." Keep on keepin on my fellow employedpreneurs.

subset: commoncrawl


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16th ANNUAL EARLY HEARING DETECTION & INTERVENTION MEETING
February 26-28, 2017 • Atlanta, GA
DSHPSHWA Registration
Registration for the DSHPSHWA Annual Meeting is open for those persons charged with the responsibility of directing and developing speech-language and/or hearing programs in the administrative units of State and Territorial Health and Welfare Agencies, or in other State and/or Federally Supported Programs for Children with Special Health Care Needs. DSHPSHWA Membership is granted upon registration for the Annual Meeting. If you have questions about registration or whether you qualify, please send an email to Kirsten Coverstone, Membership Committee Lead, at email@example.com with "Registration Question" in the subject line.
To Register:
- Register On-line with our secure server
Download the registration form
(download Adobe Acrobat free if you do not have it)
Fax to:
Mail to:
EHDI Annual Meeting
USU Conference Services
Utah State University
5005 Old Main Hill
Logan, UT 84322-5005
Registration Questions:
Call USU Conference Services at 800-538-2663 or 435-797-0421
Send an email to: firstname.lastname@example.com


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Oh Hi! Hi!
That's what Edward says when I catch him getting into something he shouldn't be getting into. It's actually fairly genius because it throws me off for a second, which is just long enough for him to move away from whatever it is he's not supposed to be playing with i.e. Daddy's telescope, candle wax, Mommy's shoes, scissors.
As much as I'm on his case, it's time for me to give myself a big "no ma'am" for all of the procrastinating I have been doing. I just realized I have about a week to get myself, my family and my house ready for the move. I'm clearly in denial, which is weird because I'm so excited! So today my goal is to get at least five boxes packed and cleanse my mind of any potential house decorating until we move in. Okay, just kidding on the last part. That's like telling me not to breathe air.
But first, I wanted to share this lovely farmhouse bedroom and sitting area from my favorite Dallas interior designer, Cathy Kincaid. I was poking around her website looking for inspiration and this caught my eye because of the black and white striped awnings peeking through the windows - our new house has similar awnings and I love the extra layer it adds to the interiors.
So many textures and colors and patterns and yet it all feels so relaxing. This bedroom is giving me lots of inspiration for the new house. Okay y'all, off to pack.
Oh Hi!
Posted by Jennifer @ Belclaire House at 8:46:00 AM
Labels: Bedrooms , Cathy Kincaid
1 comment :
Tell me somethin' good! I love your comments!
* I'll try to Reply to your Comments directly in the Comments section as much as I can especially if you have a question, so check back here if you've left a super-important comment that requires a response.
(i.e. Your Comment: what's up with the Biebs and Selena Gomez? My Reply: I don't know but it's keeping me up at night. He's so cryptic on Instagram, it's hard to really know)
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HITS.py Dan Levy, Conrad Dean, Andy Freeland An implementation of HITS using the power method and sparse matrices to reduce memory usage. Takes in a dictionary where each key is a page url. The value is a list of links at that page url. See example program in main for how to run.
src/h/i/hitsearch-HEAD/hitsearch/query.py hitsearch(Download)
from search.models import * import HITS import utils


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Meetings and Events at Parklane Motor Inn are far from business as usual. We have 3 Rooms, varying in size and layout, the central Takapuna is the perfect venue for conferences, meetings and special events.
Our Conference Rooms Feature:
View our Conference Pack by clicking here.Please contact us directly to make a booking on 09 486 1069 or use our enquiry form.


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Sheryn Lee is a doctoral candidate at the Strategic and Defence Studies Centre, The Australian National University, and a non-resident WSD Handa Fellow at Pacific Forum, Center for Strategic and International Studies (CSIS), Honolulu. She holds an AM in Political Science from the University of Pennsylvania, where she was a Benjamin Franklin Fellow and Mumford Fellow. Previously, she has been a researcher, tutor, and TB Millar scholar at the SDSC, and Robert O'Neill scholar at the International Institute of Strategic Studies-Asia in Singapore. She has previously published in Asian Security and Survival, and co-edited Insurgent Intellectual: Essays in Honour of Professor Desmond Ball (with Brendan Taylor and Nicholas Farrelly).
Geography, Power, Strategy and Defence Policy »
Essays in Honour of Paul Dibb
Edited by: Desmond Ball, Sheryn Lee
ISBN (print): 9781760460136
ISBN (online): 9781760460143
Publication date: May 2016
Power and International Relations »
Essays in Honour of Coral Bell
Edited by: Desmond Ball, Sheryn Lee
ISBN (print): 9781925022117
ISBN (online): 9781925022124
Publication date: November 2014


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Acrylic Double Walled Insulated Ice Bucket
Item: 556976
€36.95 €6.95
The Acrylic Double Walled Insulated Ice Bucket includes a lid and ice tongs. This smart and modern looking ice bucket is a great piece to have for your dining room and for entertaining guests. Comes gift boxed.
Write Your Own Review


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Dual Entrance Henderson Retail
Henderson, Waitakere City
By Negotiation
- Proposed Usage
- Retail
- Floor Area
- 100.00 m²
- Property ID
- 1bz6hr3
- Popular & busy retail centre
- Floor area 100sqm (approx.)
- Neighbouring tenancies include Fruit World, Aussie Butcher, Bakery, Curtain Studio etc.
- Generous car parking
Located on Railside Avenue the retail premises is in the heart of Henderson retail precinct. In close proximity is Henderson Train Station, Unitec, Bus stops etc.
The property has dual access with frontage to Railside Avenue and Catherine Street.
Contact the listing agent now for further information. .


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Take a look at the merchandise we are offering this year, and then click on one of the links to register your interest
Want to impress your friends and family by making them cocktails? Then buy one of our Cocktail Shakers, comes complete with a measuring jigger so you're all set!
Cocktail shaker and jigger – £10
Society hoodies – you'll be able to order your very own Cocktail Club hoodie, more to be posted soon!


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Business owners are finding it increasingly difficult to extract profits from their business tax-efficiently, and the recent pension legislation changes have restricted the amount of money that can be invested in a personal pension if the investor wants to keep all of the associated tax benefits.
To complicate matters more, the investment landscape has changed too, historically low interest rates have forced individuals to shun cash deposit accounts and to look for better returns elsewhere.
Businesses holding large sums of cash on deposit have even fewer options. Leaving business owners looking for ways to not only reduce their personal tax liabilities, but put their business cash to work.
At this event, Kay Johnson Gee and The Financial Options Group will present business owners with a few solutions to help their money work harder, earn more and make your lives a little easier.
Date: 27th April 2017
Venue: Kuits Solicitors, 7th Floor, Blackfriars House, Parsonage, Manchester M3 2JA
Cost: Free
8:30am – Registration & Breakfast
9:00am – Event start
10:00am – Event close
In Association With:


text: i've some doubt about install ios 60 , 61 , 70, 80, and these ones..because they're of other system menus, right? i have ciosx rev 19, and i want to know if a can istall other cios rev , like 20 or other number...how risky is this? my wii just accept bootmii as boot 2 like ios


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|CORRECTING and REPLACING Penske Automotive Increases Dividend
BLOOMFIELD HILLS, Mich., Nov 02, 2011 (BUSINESS WIRE) --
The dividend is payable to shareholders of record on November 14, 2011 (sted November 10, 2011).
The corrected release reads:
Penske Automotive Group, Inc. (NYSE:PAG), an international automotive retailer, today announced that its Board of Directors has approved a 12.5% increase in the Company's dividend to $0.09 per share.
The dividend, which is payable on December 1, 2011, to shareholders of record on November 14, 2011, represents the second increase this year and restores it to the level paid by the Company prior to its suspension in the fourth quarter of 2008 due to the recession. "The increase in the dividend, coupled with the 2.4 million shares we have reacquired so far this year, demonstrates the strength of our financial position, the confidence we have in the improving auto sales environment and our commitment to shareholders," said President Rob Kurnick.
About Penske Automotive
Penske Automotive Group, Inc., headquartered in Bloomfield Hills, Michigan, operates 325 retail automotive franchises, representing 42 different brands and 28 collision repair centers. Penske Automotive, which sells new and previously owned vehicles, finance and insurance products and replacement parts, and offers maintenance and repair services on all brands it represents, has 170 franchises in 17 states and Puerto Rico and 155 franchises located outside the United States, primarily in the United Kingdom. Penske Automotive is a member of the Fortune 500 and Russell 2000 and has approximately 15,000 employees.
Statements in this press release may involve forward-looking statements, including forward-looking statements regarding PAG. Actual results may vary materially because of risks and uncertainties as well as external factors such as consumer credit conditions; adverse conditions affecting a particular manufacturer, including the adverse impact to the vehicle and parts supply chain due to natural disasters such as the earthquake and tsunami that struck Japan in March 2011; macro-economic factors; interest rate fluctuations; changes in consumer spending; and other factors over which management has no control. These forward-looking statements should be evaluated together with additional information about PAG's business, markets, conditions and other uncertainties, which could affect PAG's future performance, which are contained in the Company's Form 10-K for the year ended December 31, 2010, and its other filings with the Securities and Exchange Commission and which are incorporated into this press release by reference. This press release speaks only as of its date, and Penske Automotive Group, Inc. disclaims any duty to update the information herein.
Find a vehicle: http://www.penskecars.com
SOURCE: Penske Automotive Group, Inc.
Inquiries should contact:


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Codfish for christmas
Today I decided for 2 new things.
First, to post here the exact same post as in my other blog (if you are reading the cooking one this is it), chef Nuno where I post my culinary deeds.
Secondly, for some time now, I was willing to introduce something (kind of) invented by me.
Here it is.
Doesn't have a name yet, so I launch a challenge, please post on "comments" the name you would give it, I will then ellect the best name, and the person who wins gets a bottle of Branu wine.
The pics are not the best sorry.
Basicly this is, codfish, some spinachs, sme shrimp, some garlic, some potatoe (both stewed and mashed) all built ito what you see.
I have to confess (modesty aside) it is delicius (I am eating as i write :))
Take care ya'll


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Latin America strongly rejects extreme right wing violence & destabilisation plans in Venezuela
In response to the extreme right wing violence unleashed to oust the legitimate and democratically elected government of Venezuela, nations across Latin America have come out strongly in support of President Maduro's call for dialogue and peace and rejected the recent wave of violence.
Amongst those to make a clear statement on the matter include the two regional bodies UNASUR (Union of South American nations) and Mercosur (the common market of the South).
The Mercosur (common market of the South) country members, official statement rejects all acts of violence and condemns the destabilization attempts against the government of President Maduro, repudiating "all kind of violence and intolerance which pretends to attack democracy and its institutions, whatever its origin", and reiterating "its strong commitment [to] the full exercise of democratic institutions, and in that framework rejects the criminal actions from violent groups that want to disseminate intolerance and hatred as an instrument of political struggle" in Venezuela.
Furthermore, the statement calls on all sides "to continue addressing the nation's problems through dialogue in the framework of the democratic institutions, rule of the law, as has been promoted by President Nicolas Maduro in recent weeks". (Read more here )
Meanwhile, on the 15th February, at an emergency meeting, the important body UNASUR (Union of the South American countries) also issued a statement condemning the violence in Venezuela and in support of dialogue for the peaceful resolution of domestic differences, reading that "UNASUR Member States express their strong opposition both to the recent violence in the Bolivarian Republic of Venezuela and the attempt to destabilize the legitimately democratic order constituted by popular vote.
In expressing solidarity with the families of the victims of the events, we are calling for peace and tranquility in the country and we reaffirm our commitment to the preservation of democratic institutions as a fundamental pillar of the regional integration process.
Members of Unasur repudiate any attempt to break the rule of law in the Bolivarian Republic of Venezuela and also highlight the conviction that any demand must be channeled through democratic means.
In that sense, we appeal to all political and social forces of the country to prioritize and seek dialogue for the peaceful resolution of their differences, within the existing juridical and constitutional order." (Source here)
Additionally, statements to this effect have been issued individually by numerous governments in the region, including:
- Ecuador's President Rafael Correa expressed outright condemnation of the violence and strong and unequivocal support for President Nicolas Maduro. Correa pointed out that his government has also been the target of externally-funded destabilisation plans.
- Colombia's President, Juan Manuel Santos, regretted the loss of life and the violence and called upon respectful and open dialogue. The Colombian government stated in communique that the stability of Venezuela is vital for Venezuelans, Colombians and the region.
- The government of Argentina issued a strongly worded statement warning that a destabilisation plan was afoot and regretting the opposition march that brought about violence. Argentina's statement added that the people of Venezuela had peacefully and democratically elected Nicolas Maduro as their president and that this had been confirmed by results at the 8 December municipal elections. For Argentina, the priority duty of the region's democracies was to carry act collective solidarity against "those who are seeking to replace legitimate governments that have been elected by the people."
- Cuba, Bolivia and Nicaragua also made statements along similar lines (some of these can be seen here) with the Cuban government expressing "its full support| and "call[ing] for the broadest international solidarity, convinced that the Venezuelan people will defend … the government that it freely and sovereignly elected, headed by President Maduro."
Although fortunately they have been successful only in Honduras and Paraguay, it should be borne in mind that many other Latin American countries have been recently the target of similar destabilisation plans to those seen in Venezuela in recent years, with many becoming extremely weary of externally-funded, externally-organised, and violent, campaigns of destabilization.


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New programme of business-funded scholarships announced at University of Leicester
Santander announces £175,000 three-year funding package for students and academic staff
Issued on 28 September 2010
Photo Opportunity: Friday October 1 at 11.30am in the Activities Resource Centre in the Percy Gee Building, University of Leicester
A new business-funded £175,000 scholarship programme for students is being announced at the University of Leicester.
Santander Universities Global Division has announced the three-year funding programme which includes International Scholarships and Travel Awards for undergraduates, postgraduates and academic staff.
The package of funding opportunities will mean that students can receive cash contributions towards the costs of their courses, funding towards language training and for research trips. An internship programme for students from different disciplines is also being developed.
The announcement was made as Santander opened a new branch in the University's Percy Gee Students' Union Building following a £15m refurbishment by the University.
Vice-Chancellor Professor Sir Robert Burgess said: "We are very pleased to develop this association with Santander as it provides much needed additional support for our students. We support their educational programme through a global network of universities and are keen to work with them on developing new opportunities for Leicester. We are also pleased to house one of the Bank's branches in our new Students' Union Building which will provide a useful resource for staff and students."
Luis Juste, Director of Santander Universities UK and Portugal, said: "We are delighted to support the educational development of students and staff at the University of Leicester and welcome them to our global network of universities on the eve of their 90th Anniversary. The institution is recognised for its dedication to innovation and nurturing talent, ideals we promote at Santander. I have no doubt that this partnership will be long-lasting and beneficial to all parties involved, bringing a fruitful exchange of academic, entrepreneurial and cultural knowledge."
Under the new scholarship package, scholarships will be made available for postgraduate students - beginning with the 2010 intake - from any of Santander Universities in Spain, Portugal and Latin America (Argentina, Brazil, Chile, Colombia, Mexico, Puerto Rico, Uruguay & Venezuela).
In addition, Santander will provide funds for Travel Awards for undergraduate and postgraduate students and academic staff. It is anticipated that this will be particularly attractive to outgoing exchange students from Modern Languages as well as academics in all departments.
Funding is also available for other projects including, for example, subsidised English language training for incoming students. Spanish language training for non-linguists wishing to undertake an exchange to a Santander country is also available. In addition, Santander has offered five scholarships, of up to £3000 each over three years, for the 2010 intake of Home/EU undergraduates to assist students from low income backgrounds, and particularly care leavers, to fulfil travel ambitions while they are studying. Two International/EU postgraduate scholarships of up to £5000 each will also be available.
Tania Gomez-Zapata from Mexico, who will be studying for an MA in Globalisation and Communications at the University, is one of the recipients of a scholarship. She said:
"I am extremely happy to receive one of the University of Leicester-Santander Scholarships. This support gives me the opportunity to follow my studies which, otherwise, would have been almost impossible. As a Latin American student I feel very grateful to my university and to Santander as they have opened the door for me to accomplish two dreams: to study for a Master's in the United Kingdom and then to return to my country in order to collaborate in the future of my nation."
Sandra Gomez-Sanchez, from Colombia, who will study for an MSc in Clinical Criminology, said: "I was ecstatic when I found out that I'd won the Santander scholarship as it has enabled me to further my education at a world-class university. I will therefore be able to advance my career as a Psychologist."
Banco Santander channelled 600 million Euros into sponsorship of academic, research and technological projects in support of Higher Education in the period from 1996 to 2008. There are now 900 academic institutions in Spain, Portugal and Latin America receiving support from Banco Santander including 44 in the UK.
Note to Newsdesk:
The Scholarships will be announced at a ceremony in the Percy Gee Building on Friday October 1 with the Vice-Chancellor Professor Sir Robert Burgess, Luis Juste Santander Director UK and Portugal shall be in attendance.
For more information please contact Steve O' Connor, Director of Development, University of Leicester on 0116 252 2466
*A member of the 1994 Group of universities that shares a commitment to research excellence, high quality teaching and an outstanding student experience.
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o Winner of Outstanding Student Support award, Times Higher 2009/10
o Named University of the Year by Times Higher (2008/9) Shortlisted (2006, 2005) and by the Sunday Times (2007)
o Ranked 12th in the UK by The Guardian and 15th by The Times out of more than 100 universities
o Ranked in world's top 2% of universities by the-QS World University Rankings
o Described as Elite without being Elitist by the Times Higher Education magazine
This is Leicester: http://www2.le.ac.uk/about/facts
About Santander Universities
Banco Santander, one of the largest banks in the world, created 'Santander Universities' in 1996 to support the Higher Education sector in such areas as teaching and research, international cooperation, knowledge and technology transfer, entrepreneurial initiatives, student mobility and innovation.
Santander Universities Global Division has signed co-operation agreements with 900 universities in Argentina, Brazil, Chile, China, Colombia, Mexico, Morocco, Peru, Portugal, Puerto Rico, Russia, Spain, the United Kingdom, the United States, Uruguay and Venezuela.
'Santander Universities' was introduced in the UK in 2007 through Abbey National plc and the bank is already collaborating with twenty-nine British Universities and Higher Education Institutions, with agreements focused in promoting international exchange, entrepreneurial activities and the mobility of students and researchers within the network.
For Banco Santander, investing in education is the most powerful means of promoting the development and prosperity of society.
- Interviewees needed for reception study of Holocaust films
- IRIS launch event for the Colleges of Arts, Humanities & Law and Social Science
- Participants need for online study about the need for cognitive closure
- 'Faith and Politics'
- Undergraduates wanted, for a paid opportunity to take part in a short memory study


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Course recording (Echo360)
Lecture Capture
Echo360 lecture capture system records the video and audio feeds of the classroom lecture as well as the VGA or image feed (often presented through PowerPoint slides) via the classroom projectors.
For a course to be recorded, the course has to take place in a fully equipped classroom. Only 80 classrooms are currently equipped with this technology. Use our Searching tool to see the complete list.
It also requires that the professor who offers his or her course in this type of room uses the course registration application at least 72 hours in advance.
Once the scheduled recording is done, the professor will receive an e-mail at the end of each session containing a link to the new video. These videos can be shared with the students according to the settings established by the professor. Shared videos are protected by a password and only the students can see them.
For more information on this technology, please contact the CITE at 613-562-5900 or by e-mail. We also offer workshops on techno-pedagogical tools, so please do not hesitate to consult the training program.
Echo360 Explained
See a short video on how works Echo360 (our current provider).
Video Transcription (pdf 185 kb)
You can also visit Echo360's website.
Course recording requestPlease visit our page that explains how to make a request.


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Center State Bank of Florida in Winter Haven seems to have entered the correspondent banking business at the perfect time.
The business has been earning the $2.3 billion-asset bank $1.5 million per quarter — largely because of soaring demand from community banks for bonds, said John Corbett, its president and chief executive.
"The great thing about the bond business is that it's countercyclical," Corbett said. "When banks are feeling the most credit stress, which they are now, bond sales are typically better."
Center State lately has been selling more than $1 billion worth of bonds per month to its 508 community-bank clients throughout the Southeast, Corbett said.
Bond sales account for half of the correspondent banking business, Corbett said. That helped correspondent banking contribute nearly a quarter of Center State's $6 million of income in the second quarter.
And there is no end in sight to the demand for bonds, said Steve Young, Center State's chief financial officer.
In the lending heyday that preceded the financial crisis, loan-to-deposit ratios of 100% were common.
"Because of the 'great deleveraging," it's now 90%, and I predict it will fall into the 80% or 75% range," Young said. "So there's tons of liquidity on banks balance sheets."
Center State entered the correspondent banking business in November of 2008. Early that year, Alabama National BanCorp., along with its 11 subsidiary banks and affiliated businesses, was acquired by Royal Bank of Canada's RBC Centura Banks Inc., for $1.6 billion. In the fallout from that deal, Center State was able to hire 17 bankers who had helped run the correspondent banking business for Alabama National.
Center State moved decisively again after the April 2009 failure of Silverton Bank of Atlanta, a wholesaler bank with roots as a banker's bank.
At the time of its failure, Silverton had approximately 1,400 bank customers and $4.1 billion of assets.
Silverton's collapse opened the door for more correspondent banking growth at Center State. It snapped up Silverton's capital markets team and some of its operations employees, increasing its correspondent banking staff to 70.
With its team in place, it was able to help fill the huge vacuum left by the demise of Silverton and Alabama National, Corbett said.
"There was a big void in the Southeast with the loss of those two banks," he said.
Key Silverton employees who joined Center State included three senior vice presidents — Brad Jones, who was senior vice president and led the bankers' bank's capital markets operation; Kellie Endres, who oversaw the payment solutions group; and Brett Rawls, head of business development and marketing.
That trio was tapped to manage the correspondent banking business out of Atlanta.
Center State now has a fixed-income desk in Atlanta and another in Birmingham.
When Center State hired the management team, the bank had about 200 bank clients throughout the Southeast.
Largely by courting former Silverton clients, it has more than doubled that number.
Other banks that provide bonds to community banks are thriving as well.
At United Bankers Bank in Bloomington, Minn., bond sale volume and revenue are running at double 2007's rate, according to the bank's chief investment officer, Ben Eskierka.
Through the first half of 2010, United Bankers Bank sold $1.1 billion of fixed-income securities to 533 community banks, Eskierka said.
Those bank clients, located throughout the upper Midwest and Pacific Northwest, are buying agency bonds, agency mortgage-backed securities and municipal bonds, along with a sliver of low-yielding Treasuries, Eskierka said.
Community banks are buying more bonds because of the combination of higher deposits and fewer loans, regulatory pressure for more on-balance-sheet liquid assets and the low rates of Treasury bonds, Eskierka said.
When the economy improves and Fed funds rate rises, he said, demand for fixed-income instruments should fall.
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On these hot summer days, it can be hard to find something to keep your active toddler occupied.
Here is a list of 5 fun activities to keep your toddler occupied! 🙂
1. Water fun outside!
Whether it is in a kiddie pool, playing in the sprinklers, or having a "tea party" with water, letting little one play outside in the water is a great way to escape the heat and keep them entertained for hours! Throw in a few pool toys, squishy toys {waterproof, of course}, or even some ice cubes and you have yourself some great sensory play, as well! Just be sure to apply lots of sunscreen 😉
2. Send them on an indoor scavenger hunt!
On those days that it's too hot to even be outside in the water, you can create an indoor scavenger hunt for them. Even for the ones that can't read clues yet, you can do picture clues. My little one loves the adventure in finding things. Start with a clue with a picture of one of their toys hidden {where they can find it} and then have that toy holding the next clue. You can also have them find different people in your house for the next clue or send them to the fridge to find the next clue. Be as creative as you want! You can make this game as short or long as you want. For the final thing that they need to find, have a "prize" or "surprise" waiting for them! The feeling of accomplishment and finishing a task will be a great boost for your little one! 🙂
3. Build a fort!
I'm sure that you remember building forts as a kid. Do you remember how much fun it was building it and then hanging out in it all afternoon? Well your kids would have just as much fun building their own fort! You can show them how to start it, and then let them finish building it. Turn it into a family event. Give them blankets and pillows to put inside, show them how to keep a part open to see the t.v., let them make popcorn and have a movie night together in the fort! You will be making memories that will last them a lifetime 🙂
4. Art time!
Depending on how much your kids like arts and crafts, this activity could keep your kids busy all day long! You can set up your table with crayons, markets, paint, and paper and let your kids go wild! {Use your judgment on what your kids like.} Give them a prompt like "draw or create mommy's day" or "draw or create a superhero world". I guarantee what they come up with in their huge imaginations will amaze you!
5. Obstacle Course
You can create an obstacle course in your house that consists of pillows, blocks, toys, chairs, etc. that they have to get over, under, around… Whatever you want, and whatever you are comfortable with, wear and tear wise, with your furniture. I know my little one LOVES to be climbing all over everything. This is a fun way to channel that energy. You can put rules on it, like you can't touch a certain color on the ground, or you have to hop on one foot. You get the idea 😉 This will keep them engaged and entertain for hours!
6. Mix and Match
Depending on the age of your little one, you can create flash cards with upper case letters and lower case letters and have your kiddo match them. If that is too advanced for them, try matching shapes or colors. If letters is not challenging enough for them, have them match rhyming words or words that start with the same letter. If you need help creating these or templates, let me know!! 🙂 I'm glad to help!
Enjoy these activities and have fun with your little ones this summer!!! I would love to hear from you guys if you need more ideas or would like me to post some fun games {with rules and set up included} 🙂
Don't forget to go and check out www.thedesignermama.com for other great articles.


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Cheap hotel, close to beach, free wifi. That's all about this hotel. The room is small and dirty. The bathroom looks even scarier. The lift is very old and it shook every time we used it. We felt unsafe. The breakfast is terrible.
this is a big hotel but in this hotel don't have any special. me and my friend have been here for 3 days. the room is nice, comfortable but their service is nothing special. they not too good to predict what their customer want. anyways...More
The hotel is very good location - near the sea and not so far from the center.
Good Breakfast, clean rooms.
A very friendly staff.
Near the market and many rfst bars and restaurants.
For the three stars is not even bad.
Near the hotel...More
I felt more than 5 stars hotel...so lovely staffs, excellent service. The manager was so professional and helpful. She always helped us with tours arround Nhatrang. We loved having dinner with her sometimes.
There is nothing to recommend this hotel. It was a major error on my part to have booked it in the first place. I usually do a better job.
Arrived early so room was not prepared. Not fault of the hotel. But, the lobby area...More
"room on top floor is nice view"
"Strongly advise against staying at this hotel"


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There is an enormous clinical need for liver transplant tissue, with millions of patients all over the world. Now, scientists have successfully produced the most realistic liver tissues ever created – bringing new hope to many lives.
Scientists at a The Saban Research Institute of the Children's Hospital Los Angeles created the liver with the help of both people and mice, the study published in the journal Stem Cells Translational Medicine said.
Using stem and progenitor cells obtained from human and mouse livers the researchers generated the so-called liver organoid units (LOU) which were later implanted into mice. The LOU then developed into a liver with bile ducts, blood vessels, hepatocytes (liver cells involved in bile production) and other cells required for it to function. What is more, the tissue-developed organ produced albumin – the same protein a human liver generates.
The tissue-engineered liver did not fully resemble a human one as there were differences in cellular structure, scientists noted.
Scientists came up with the idea of obtaining a lab-grown liver after a series of fruitful experiments aimed at generating intestinal tissue.
"Based on the success in my lab generating tissue-engineered intestine and other cell types, we hypothesized that by modifying the protocol used to generate intestine, we would be able to develop liver organoid units that could generate functional tissue-engineered liver when transplanted," said Tracy C. Grikscheit, a pediatric surgeon and researcher at The Saban Research Institute of CHLA and co-principal investigator on the study.
So far donor liver transplantation has remained the only effective method for coping with end-stage liver diseases. The method is considered challenging due to the scarcity of donors and the need for patients who undergo liver transplants to be treated with immunosuppressive drugs during their whole life so their body would not reject the implanted organ.
While there continues to be a need for a more durable treatment, scientists express great hope in the new development, saying the lab-grown liver might be capable of easing the plight of many patients.
"A cellular therapy for liver disease would be a game-changer for many patients, particularly children with metabolic disorders," said Kasper S. Wang, a pediatric surgeon and researcher at The Saban Research Institute of CHLA and co-principal investigator on the study. "By demonstrating the ability to generate hepatocytes comparable to those in native liver, and to show that these cellsare functional and proliferative, we've moved one step closer to that goal."
Source: Science Mag, RT


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A 23-year-old man was hospitalized after he was cut in the face and body with a broken bottle at the Green Dolphin Street nightclub early today, police said.
The incident happened at about 1:45 a.m. at the nightclub, 2220 N. Ashland Ave., police said.
The victim told police that he was involved in a verbal altercation with two men, said Chicago Police News Affairs Officer John Mirabelli.
After the verbal altercation, the men returned with a broken bottle and they cut him in the face and body with the bottle, Mirabelli said. The men fled after the attack, Mirabelli said.


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November 3, 2009 (CHICAGO) --A federal judge could decide Tuesday if a Chicago businessman accused of plotting a terror attack overseas will be released on bond.During a hearing last week, prosecutors called Tahawwur Rana, 48, a danger to the community and a flight risk and said he should be denied bond.
Rana's attorney says he's innocent and was duped by the other man charged in the plot, David Headley, 49.
An attorney says friends and family of the Chicago man accused of taking part in a terrorist scheme to attack a Danish newspaper are willing to post $1 million in real estate and cash to win his release on bond.
Rana and Headley are accused of plotting to attack a Danish newspaper that published cartoons in 2005 depicting the prophet Mohammed.
Rana, who owns a business on Devon and a farm southwest of Chicago, is due in court Tuesday afternoon.
The Associated Press contributed to this report.


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CHATSWORTH, Calif. — Steve Driver, the murderous "mope," who in the summer of 2010, took his life after fatally stabbing performer and friend Herbert Wong — aka Tom Dong — and wounding two others with a samurai sword at the production offices of Ultima DVD, is the subject of an upcoming episode of "Fatal Encounters."
Set to air in May on the Investigation Discovery channel, the show features interviews with people who either knew or came into contact with Driver (legal name Stephen Clancy Hill) during his misguided, often disappointing, pursuit of porn stardom, including Ultima DVD owner Eric Jover, who had allowed Driver to live at his production studio up until Driver's behavior became unbearably erratic.
Jover told XBIZ, "The events of that day made me realize how easily and swiftly one's mortality can be taken away by the anger of another person, and this made me more intuitive in handling all types of relationships and situations. It has shifted my focus on creating a strong, positive atmosphere with everyone on and off set, and it really has driven me to become more focused on creating mutually beneficial relationships throughout the industry that are beyond monetary value."
While Jover understands the sensational appeal of Driver's story, he hopes that the Discovery Communications program will "put the many people in the adult industry under the proper light."
He explained, "I shared with them how much labor is actually involved in the creation and distribution of adult content, and I hope they portray us to be ambitious, hard-working Americans instead of people who are glamorized or superficial."
Also slated to appear in the episode are Christopher Rachal, the Ultima studio manager who was nearly hacked to death by Driver when he attempted to evict and fire him, Driver's heartbroken father David Hill, porn star Charley Chase, who starred opposite Driver in Robert Hill Releasing's "Tea Baggin' Party," and would later comment to the media about his horrible on-set body odor and writer Mike Albo, whose piece on the events "Porn Machete Murder" was the most popular story of 2011 on LAWeekly.
Albo, a former adult industry publishing veteran, told XBIZ that he believes the tragedy of Driver's story will resonate with viewers more so than its porno elements.
He said, "I think people will see that everybody has dreams and aspirations and when those are shattered and taken away, it's devastating. Most people accept it and readjust their sights. But an unstable person — especially one with a history of failures and disappointments — can lose his grip and become a danger to himself and those who are unlucky enough to be around him when it happens."
Driver eluded police for three days after the attack at Ultima DVD, but was finally tracked down to a hillside bluff near the Chatsworth Nature Preserve in the San Fernando Valley. He held LAPD SWAT at bay for eight hours, while threatening to kill himself with yet another sword. When authorities finally attempted to bring Driver in with the aid of tasers and bean-bag projectiles, he leapt off the cliff to his death 50-feet below.
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