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As orignially appeared in AMi Living Whisk magazine:
The Culinary Journey
Over the next few months, Whisk is taking you on a culinary adventure. Every four weeks, you'll meet another Jew from across the globe, cooking with their distinctive flavor and flair.
Though our time zones are different, we'll catch up with each of them for a quick chat…before we're treated to a delectable meal. As you learn about their culinary styles and peruse the fresh the recipes every month, you're certain to end up with a few original ideas to bring excitement to your own cooking.
Victoria Dwek - Mangaing Editor Leah Schapira - Food Editor
In our first stop, we're meeting Shulie Madnick. Shulie is of Indian Jewish ancestry, born and raised in Israel. That explains the Indian and Mediterranean flavors in these recipes and on her Food Wanderings blog.
A Little Bit of Cardamom
Recipes and Photos by Shulie Madnick
"Hi Shulie…we know that some people are born with a wooden spoon in their hands and some find it only later. When did you fall in love with cooking?"
"When I was growing up, cooking was like an assembly line. We were four girls and two boys. We girls all had tasks; I was great at rolling out perfect circles with a rolling pin for breads or stuffed steamed sweet dumplings called Laru, similar to Chinese dumplings. The dough was stuffed with sweetened coconut and nuts or sweetened semolina and nuts. There's a fun contest that newly married couples have a custom to play—they challenge each other as to who can take the Laru out of the steamer intact. Back then, I think I got some of my mom's touch in me but I didn't realize it until much later on in life."
"Your mom is a good cook?"
"My mom is an excellent cook! She is truly gifted. She got that special touch not many possess. She mostly cooked Indian food while we were growing up."
"Did you start out cooking only Indian food too?"
"Yes! Most foods other than Indian and Israeli tasted bland to me. Slowly I began to like Thai, no wonder, as it's packed with a punch of flavor. Now I can even appreciate steak and potatoes. I like to be minimal at times and let ingredients shine without masking their pure flavor. So now, while my main repertoires is Mediterranean and Indian food, my cooking is versatile a fusion of sorts. I can cook pretty much anything. If I am unfamiliar with a certain cuisine it's just a matter of something sparking my interest and me putting my mind to it. I can make Italian pasta sauce and gnocchi from scratch, sushi, and recently explored Indonesian cuisines. I also like to develop fused recipes that cross different cultures."
"What's your family's favorite?"
"Chicken curry! I bring the mixed spices back from Israel. It's the exact ratios of different ingredients that go into a curry mix I grew up on. The base is nicely caramelized onions, cilantro, jalapenos, tomatoes, garlic, and curry powder, then chicken and potato added once the base is cooked well."
"And what's your personal favorites? If you were stuck on a desert island, what three foods could you live on."
"Hmmm, I can live off Indian food every day. It has coconut, it has mango and its range is versatile. Not many people know that Indian food can sometimes be subdued. If I had to pick…my three favorites are samosas, halwa, and the chicken curry. Samosas are fried triangle dough filled with spiced potatoes and peas. Some of the spices in there are red pepper and cumin seeds. Halwa is a desert. It's sweetened milk with corn flour and cardamom, and churned on stove until smoothly thickened. It's poured into a shallow dish called Talla and chilled in the fridge. The consistency becomes jello-like. Halwa tastes similar to the Israeli/Mediterranean Malabi."
"What special ingredients do you use that make your dishes Indian-inspired or flavored?"
"An instant simple Indian touch can be a cheap and accessible herb, the cilantro. That will give your dish a bit of an exotic touch without any heat added. Also, add a touch of cardamom to desserts. If you put anything sweet with a hint of cardamom in it in front of me it will always be a success in my book! Never fails!"
"What if someone is new to Indian food and wants to incorporate these new flavors without putting a whole menu of new things on the table. What do you recommend?"
"If you buy curry powder, use just a sprinkle, not the full dose asked for in an authentic recipe. Also start with something you can relate to, like the peach salsa to add to a latke, for example, instead or in addition to apple sauce."
"You obviously know your stuff. Would you admit to any kitchen disasters?"
"Yes! Two in fact. Early on, just after I got married, I made super burnt popcorn. We had to toss away the microwave and air the house for days. I also once left house with hard boiled eggs on the stove and came back to an incredible mess! It was in our first rented apartment in old Ramat Aviv in Israel."
"Lastly—what's your favorite cookbook on your shelf today?"
"I like Paula Wolfert's Couscous and Other Foods of Morocco. It's very well researched. As much as I love visuals, even without a single image, I adore it. There's some amazing recipes, especially for the holidays, like lamb and honey."
"Thank you Shulie…now let's look at those refreshing recipes."
20 Minute Indian Salmon in an Envelope
This is a quick and easy oil free recipe. You can be creative with it. One day you can bake for 20 minutes with an Indian flair as shown in this recipe. The next time you make it, slather it with, even a store bought, basil pesto for an Italian fare. It's wonderful for a midweek casual meal, as well as to wow your guests on a special occasion with the eye catching parchment paper envelope presentation. Whether you serve at the dinner or buffet table as a center piece, or individually wrapped in personalized envelopes of parchment paper, you're sure to draw many compliments for the flavor, technique and presentation. Serve with the peach chutney/salsa on the side or as a touch above.
1 pound salmon fillet (whole or cut into four ¼ lb each)
Couple dashes—½ teaspoon curry powder (found in any supermarket spice isle), optional
Salt to taste
Black pepper to taste
1 sliced tomato
1 sliced lemon
Few sprigs of fresh cilantro leaves and a couple extra as a garnish. If not using curry powder, you can use parsley sprigs instead of cilantro
Parchment paper or aluminum foil
1. Heat up oven to 400°F.
2. Wash salmon fillet in cold water and tap gently with paper towel to dry.
3. Layer a baking dish with foil or parchment paper. Lay washed and patted dry salmon fillet on top of parchment, salt and pepper to taste and sprinkle some curry powder on top.
4. Layer with sliced lemons and sliced tomato on top of salmon. Add cilantro leaves on top of tomato and lemon slices.
5. Cut another large enough parchment paper as a tent to cover salmon on top. Fold bottom and top edges of the parchment paper all around to keep moisture in.
6. Bake for 20 minutes. Watch out for the steam as you open parchment envelope while the salmon is still hot.
7. Garnish with additional fresh cilantro leaves and serve with peach chutney/salsa.
Yield: serves 4
Cook's note:I will let you in on a secret if you are short on time. Layer foil or parchment paper on a baking sheet. Prep the fish as described above and layer another sheet of foil or parchment paper on top like a tent, without folding edges and voila—into the oven. It works just the same!
Indian Chutney/Salsa/Relish
I like to give the original mango chutney (an Indian salsa/relish) a seasonal twist and use a fruit that is in season, such as yellow peaches I see everywhere nowadays. You can use nectarines and mangoes. If you do not like too much heat, you can leave the jalapeno out and the salsa will have a fresh fruity cooling effect complimenting grilled chicken or the 20 minute Indian salmon. You can use it as a condiment or scoop some with tortilla chips. I diced all the ingredients but you can always whizz all ingredients in a food processor while giving it only a few pulses or more depending on the consistency desired. I prepare it both ways. My mom, in Israel, likes to grind it in a meat grinder reserved only for this and her other pareve dishes.
4 just ripe yellow peaches, cored, peeled and diced
Juice of ½ lime
1/4 of large red onion diced
1-2 minced garlic (optional)
4-8 fresh mint leaves chopped (julienned)
4-8 sprigs of fresh cilantro, chopped
1/2-1 seeded jalapeno, diced (optional)
1/4 teaspoon salt
1-2 teaspoons sugar
Coconut flakes as a garnish (optional)
1-2 tablespoons oil if keeping longer than couple days refrigerated
1. Add diced peaches into a bowl and drizzle lime juice immediately onto the peaches and mix. This avoids peaches from oxidizing and turning brown. They will stay beautifully vibrant.
2. Add the onion, garlic, mint leaves, cilantro, jalapeno, salt, and sugar. Mix and garnish with coconut flakes.
3. Or as in the introduction above, whizz all ingredients in a food processor including the coconut if you wish. Serve with 20 minute Indian Salmon.
Yield: serves 4
Shekem, Simple Dough and Eggplant Roulade
Israeli Shekem doughis the go-to Israeli sour cream dough. It's simple, yet packed with flavor. It's perfect for the many vegetarian meals Israeli tables are adorned with, whether at their famous brunches or at the dinner table. Shekem is an acronym, stands for three letters in the alphabet Shin, Koof, and Mem.Shin stands for Shamenet,which would be plain yogurt or sour cream in the States. Koof stands for Kemach, which is flour and Mem stands for margarine or as in this case, I used butter. Eggplant and yogurt are staples in the Indian kitchen and this roulade can be adapted to compliment many cuisines from European, American menus as well.
About 7 ounces sour cream
2 1/2-3 plus cups self-rising flour
7 ounces unsalted butter at room temperature
¼-½ teaspoon salt
Eggplant Filling:
1 pound eggplants (enough for 3 roulades)
2 tablespoons canola oil (or any other vegetable oil)
Pinch salt
Freshly ground black pepper
Handful parsley, chopped
Any grated or crumbled cheese you have at home, about ¾ cups, 1/3 cup for each roulade (optional)
1 egg for egg wash (brushing the filled dough on top to achieve a golden hue)
1. To prepare the dough, mix 2 1/2 cups flour, salt, butter, and sour cream in a mixer (or by hand) with paddle attachment. If the dough is too moist, add a bit more flour and continue kneading by hand until a (very) soft delicate dough is formed.
2. Wrap in plastic wrap and keep refrigerated for at least two hours until use. It's best when chilled. Cut dough into three portions before rolling out. Dough advantage: Dough can be prepared 3-5 days ahead and kept chilled in the refrigerator. It can also be frozen and used later.
3. To prepare the eggplant filling, cut the stem off. Cut eggplant into roughly ¼ of an inch thick round slices or lengthwise, brush with oil and sprinkle with salt on both sides.
4. Preheat oven to 350°F.
5. Lay sliced eggplant on a parchment paper lined cookie sheet and roast for 25-30 minutes. Flip eggplant slices with a spatula and continue roasting for 15-20 minutes longer or until golden on both sides. Remove from oven and let cool. Filling advantage: This step can be done a day or two in advance and roasted eggplant can be kept in refrigerator.
6. To assemble the roulade, dust a rolling surface with some flour and roll out 1/3 of the dough into a thin rectangle.
7. Layer the filling 1/3 way up from the edges of rolled out dough along the longer side in a long strip. Leave some unlayered dough space for folding around wider sides as well. Do not spread filling over entire surface; a thick strip is enough.
8. Add parsley and grated or crumbled cheese on top of eggplant.
9. Fold narrow/wider side edges in and then fold bottom and top parts (longer sides) of dough to envelope the filling into a roulade form.
10. Beat the egg and brush top of roulade with the egg wash. Place roulade into an oiled parchment lined baking sheet and proceed to assemble next two roulades.
11. Once assembled, bake for 35 minutes.
12. Serve immediately or at room temperature. You can also freeze roulades. Let thaw and reheat for about 20 minutes. Reheat in oven only (not in a microwave) before serving.
Variations:You can assemble individual servings instead of long roulades. You can also add roasted bell peppers to the eggplant mixture.
Yield: 3 long roulades
Israeli Fruit Salad
In this classic Israeli fruit salad you can use any fruit you have in the house other than watermelon and melons. Apples, bananas, and citrus (at the least orange juice) are keys as a base. You can go from there and be creative. This is a large fruit salad and keeps well in the fridge for a couple of days. You can serve it with a dab of whipped cream, scoop of sorbet, vanilla ice cream, or meringue kisses broken into pieces for contrast of textures. I added mango as it is in season and gives this Israeli fruit salad an exotic Indian twist. During the winter you can use sectioned citrus, in the summer, peaches and so on. You can add ¼ teaspoon of cinnamon or two cinnamon sticks. For an Indian twist you can add ground cardamom found in any supermarket spice isle. I only cored the apples and pear since I liked the depth the color of the skin adds. You can certainly peel the fruit. You must peel the mangoes (I used a potato peeler). Sugar and honey are optional but I like to add sugar to mine; my friends don't. So this salad can be super healthy or you can just a tad indulge!
4 medium apples, cored and diced
1 large pear, cored and diced
2 large bananas, peeled and diced
2 handful grapes (about 40), halved
Juice of one large lemon
2 cups orange juice
0-4 tablespoons sugar or honey (depending on taste)
2 mangoes, peel, slice along pit while holding mango standing on stem, dice
¼ teaspoon cinnamon, 2 cinnamon sticks or ¼ teaspoon of cardamom (optional)
1. Immediately after dicing apples, bananas, and pear sprinkle these three fruits with some of the lemon juice to avoid oxidizing and turning brown.
2. Combine all fruit together, mix in remaining lemon juice, orange juice, sugar or honey if you wish according to taste (4 tablespoons at the max).
3. Stir in cardamom, cinnamon or cinnamon sticks if you wish. If adding spices, add only one of the three.
4. Cover with a plastic wrap and chill before serving.
4. Serve salad on its own or as suggested above.
Yield: serves between 10-12 people
To rate and review the recipes: Israeli Fruit Salad, Shekem, Simple Dough and Eggplant Roulade, Indian Chutney/Salsa/Relish and 20 Minute Indian Salmon in an Envelope
Thank you so much Leah and Victoria. The feature turned out so well. Was such a pleasure working with you both. You gals are the best!! Was such a fun process for me to snap the shots and develop the recipes for this article. Thank you so much for the opportunity!! Leah you are such a shadchanit!! Love your site!!
Thanks Shuli. Likewise!
Nice! Looking forward to read more interviews.
Loved this! Can't wait until the next adventure-almost as good as going to these countries. Very exciting and looking forward to trying out these recipes. You guys have great ideas!!!!!!!!!Thanks


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students are enrolled at RWTH Aachen University in the winter semester of 2017/18.
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read more...zu: 5 vor 12 – The RWTH Aachen Night of Science

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LSC-PA Seahawks upset top ranked team at NCJAA tourney
HUTCHINSON, KS - The NJCAA's top-ranked team coming into the tournament was eliminated Thursday afternoon when Lamar State - Port Arthur upset Missouri State - West Plains 69-62 at the Hutchinson Sports Arena. Poor shooting and 25 turnovers were the demise of the Grizzlies.
LSC-PA also won the battle of the boards, out-rebounding MSUWP 40-31. Vonn Jones led the Seahawks with 19 rebounds, five rebounds and four assits. Darrion Booker came off the bench to score 17in the second half and also had nine rebounds.
Twann Oakley scored 17 to lead the Grizzlies, who finish up the year at 31-4.
LSC-PA (26-10) will next play in the consolation semifinals on Friday against Cape Fear Community College (25-8) of Wilmington, N.C., at 1 p.m.


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|Assistant Coach
|Alma Mater:
|UC Davis
|Graduating Year:
|10 Years
Mike Kuoppamaki is in his ninth year as pole vault coach for the University of California San Diego track and field program in 2018. Kuoppamaki adds a wealth of experience to the Triton staff, having coached in the college ranks since 1999 at UC Davis, Boise State and San Francisco State.
Kuoppamaki has worked with two individual national champions, as well as several California Collegiate Athletic Association champions and national All-Americans. In addition, he has sent two athletes to the U.S. Olympic Trials.
In his first year with the program in 2010, Kuoppamaki coached Donna LeFever, who set the school record in the pole vault with an impressive mark of 12'6". LeFever went on to finish sixth (12'2.75") at the NCAA Championships in Charlotte, N.C., becoming the first Triton to earn All-America accolades in the vault on the women's side.
Kuoppamaki graduated from UC Davis with a bachelor degree in Neuro Physiology and Behavior in 1998. He placed fourth at the NCAA Championships in the decathlon while competing for the Aggies, and then went on to place 13th at the U.S. Nationals in 2003. Kuoppamaki received his Doctorates of Chiropractic in 2008 and now works in San Diego.


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Mixed-use mayhem
Windows 8 provides a solid desktop experience. Its tablet experience is, in spite of the rough edges, workable, with many enjoyable parts. And as long as you stick to one way of working or the other, you can be pretty happy.
Where it falls down, hard, is when you try to mix and match. Microsoft has done precious little to bring the Metro environment and the desktop environment together. They're two separate worlds. The charms, in particular, are off-limits to desktop apps. The Search charm won't search the foreground desktop app. Desktop apps can't share or be share targets. Desktop apps don't know about devices, and don't store their settings behind the Settings charm.
This makes a mix-and-match approach deeply flawed. I can't even send an e-mail via Outlook from the Metro world. Outlook. Probably one of the most important business applications of all time, and Metro doesn't even know it exists.
We get the same problem in reverse, too. If you use the Metro Mail app as your e-mail client, you might expect that you could right-click a file in Explorer, and then go to Send to, Mail Recipient, and for this to create a mail in the Mail app. You might expect that, but it won't work. Send to Mail Recipient can only use desktop Mail apps. How about sending someone a URL to a webpage from within the desktop Internet Explorer using the Share charm? Nope, not an option; desktop Internet Explorer can't send to the Share charm. Nothing on the desktop can.
Making matters worse is that, by default, Windows 8 is configured to use this mix-and-match approach. I already mentioned things like defaulting to using the Metro Photos app instead of the desktop Photo Viewer app, so let's explore that in detail. I often get sent ZIP files of images (product photos, that kind of thing). So I unzip them all into a directory somewhere. I then want to look at them, so I double-click one of them. In Windows 7, this would open up Photo Viewer, and I can just use the arrow keys to cycle through all the images in the same directory. Quick and easy.
In Windows 8, however, the first image opens up in the Metro Photo app. And here's the problem: the Metro Photo app can't view the rest of the images in the directory. Why? It doesn't have permission. It's another one of those security things: Metro apps can't read arbitrary directories on disk. They can only read files explicitly selected by the user, and files in one of the libraries (which, incidentally, can only be managed from the desktop).
So instead, you open the first file, then either quit the Photo app or alt-tab back to Explorer, open the next file, then switch back to Explorer, open the next, and so on.
OK, you might say, so put the folder in the Pictures library. Do that, and the Metro Photo app does the right thing; you can open the first file and then navigate to its siblings just fine, without having to flip back to Explorer the whole time. But I may not want to put the pictures in the Pictures library. I probably want to put them in the Documents library, alongside the PDFs, Word documents, and Markdown files that comprise a piece of work. But if I do that, the same problem occurs. The Metro Photos app can't read from the Documents library. It's only allowed into the Pictures one.
The separation also makes the Start screen's Live Tiles much less useful. Again, to use Outlook as an example: Outlook can't display Live Tiles. It can't give me a mail notification on the Start screen, nor on the lock screen. It can't show me my next appointment on the Start or lock screens either. Why? Because only Metro applications are allowed Live Tiles.
This is vexing in Windows 8; it's arguably even more annoying in Windows Server 2012. The Start screen could make an ideal at-a-glance console, with Live Tiles to indicate the health of various system components and services. Except it can't do this, because doing that would require Live Tiles that were generated by desktop applications, system services, and PowerShell scripts.
There is a hard and dividing line between the two worlds. Far from allowing seamless switching between the two environments, they barely even acknowledge the other's existence. It's extremely limited, and it means that as a person who has to use the desktop for some things, I find myself avoiding Metro apps for all things. Bridging the gap is just too painful and annoying.
The only silver lining to this cloud is that there's no real technical reason for these restrictions. It would be relatively easy to, for example, allow desktop applications to participate in the share contract and other mechanisms. I've heard claims that other scenarios are being considered too, such as allowing drag and drop from the desktop into Metro apps. So the situation could improve in some future version.
Right now, though, it's a big pain point. Until this gap is closed, it leaves Windows 8 feeling like two separate operating systems poorly grafted together. You can never avoid the join entirely, but your happiness with Windows 8 will depend heavily on just how often you have to cross over. The more you try to treat the two worlds as equal, integrated peers, the worse Windows 8 gets. The more you stick to one paradigm or the other, the better it is.
Store stuttering
If Windows 8's only revolution was its new user interface, that would be significant enough. There are other sea changes in store, however. In the Windows Store.
Metro apps do not merely have a new user interface. They're also distributed, downloaded, and (optionally) purchased in a new way. They all have to be vetted by Microsoft and then distributed through the Windows Store.
App stores have become expected, mandated parts of smartphone and tablet platforms. The Windows Store is in the familiar Apple mold. Microsoft exercises strict editorial and technical control over apps listed in the store, restricting both their content and access to the operating system.
While enterprise customers will be able to bypass the store and privately distribute custom applications, there won't be any general-purpose way for normal users to side-load Metro applications that haven't gone through—or couldn't go through—Microsoft's validation processes.
I'm not a fan of this approach when Apple does it, and I'm not a fan when Microsoft does it. While I understand that there's a certain amount of peace of mind that comes from a tightly controlled store and a locked-down system, there's also a tremendous loss of freedom. I don't mind that Windows 8 has a store, and I'll probably make purchases on it myself. I do, however, think there needs to be the facility to at least opt in to allowing side-loaded applications. I don't think Microsoft should have the final say about what applications I can run on my PC.
The Store experience itself is mediocre at best. It does all the basic things. It has a categorized listing of apps and a spotlight section for promoting hot apps. It features searching, app ratings, and so on. That's all fine, if unexceptional. It also has a hugely convenient "install all the apps I have licensed" capability, something I find sorely missing from Windows Phone. This will fetch all the free and paid apps that you have used on other machines and install them locally.
Where it falls down is that I've not found it very reliable. Its Live Tile will show that I have updates available, and I'll click the update notification within the store... only to be shown that there aren't any updates available.
Other times, when installing or updating apps, it will appear to get stuck and not manage to download anything. One time it showed me updates for two apps, I told it to install the updates, and nothing happened. It just stayed on the same page, showing me the two updatable apps.
For the most part, quitting and restarting the app, or failing that, rebooting, would fix its problems—at least temporarily. But the overall experience isn't very good. Installing and updating apps is a core experience: it shouldn't be unreliable, and it shouldn't be unpredictable. Yet the Store app is both.
In fact, I would even go so far as to say that the Store app is the worst of the built-in apps. Some of the other apps frustrate me due to their simplicity, but none of the others are as janky as the Store app. As often as not it will do something weird and unwanted. For such an important use case, I don't really think this is good enough.
Head in the clouds
The final big change in Windows 8 is Windows' new relationship to networked cloud services in some significant ways, particularly concerning user accounts.
When creating user accounts on Windows 8, two options are available. You can create a regular local account that works just like any user account on prior versions of Windows, or you can use a Microsoft Account. With a Microsoft Account, your local account is cloud-connected.
Microsoft Accounts were formerly known as Windows Live IDs. They're accounts and credentials used to sign in to various Microsoft services, and they're often paired to things like Hotmail or Outlook.com e-mail accounts and SkyDrive storage. They can also be associated with Facebook, Twitter, and Skype identities (among others) and can carry around billing information.
If you sign in to Windows with a Microsoft Account, a few things happen that don't occur with regular local accounts. First, certain applications get plumbed in to their respective services automatically. For example, the Mail app gets configured to use your Hotmail or Outlook.com account. SkyDrive knows your identity and can sync your cloud files. The media apps like Music and Video can similarly log in and have the ability to use your stored billing information for making purchases.
The cloud connectivity does more than just let your local apps know who you are. Windows 8 offers synced settings via the cloud. Log in at a machine for the first time, and it will configure your color scheme, passwords, browser history, preferences in Explorer, linguistic predilections, keyboard options, and even third-party application settings. Almost as soon as you log in, the machine is made your own, with all the familiar setup that you expect.
I only wish the feature were extended. To use Microsoft Account you still have to explicitly create a machine account that is configured to use a specific Microsoft Account. What I'd like even more is a kind of combined Microsoft Account/Guest account—so that I could log on temporarily to someone else's computer, using my own Microsoft Account, have it plumbed into my e-mail and apps appropriately, and then discard all the personal data when I log back out.
Beyond the interface
There's a lot more to Windows 8 than its user interface. In a normal Windows release, these other aspects—a new storage subsystem that lets you join multiple disks together, a new backup system, reduced memory usage, greater protection against security exploits, portable installations on USB memory sticks and more—would be prime considerations when assessing the operating system.
In the coming days, we're going to take a closer look at some of these features, but the user interface changes in Windows 8 threaten to overshadow them all. Some people have had visceral, negative reactions to the new user interface, and they're more than willing to forego these other improvements so that they can stick with Windows 7's much more familiar face.
If you're a desktop user, then yes: the new interface is not perfect. Despite what Microsoft says, the new interface is a compromise. The new interface makes some things worse. It also makes some things better. If you're a multimonitor user, I would think long and hard before upgrading; as welcome as the new taskbar is, the ease of use of the new interface is a severe problem with multiple monitors.
With a single screen, however, just treat the Start screen as little more than app launcher and be selective about your use of Metro, and it turns into something that actually works pretty well. Maybe even something better than Windows 7.
That may not be enough for everyone, particularly in corporate environments scared of retraining costs, but Windows 8 shouldn't be dismissed out of hand. Should you go for the new operating system, you won't lose any performance, and you can even get away with an in-place upgrade.
If you're willing to look beyond the desktop, Windows 8 offers something altogether more exciting. There have been hybrid and convertible laptops in the past; machines that can switch between being what is essentially a laptop and what is essentially a slate/tablet, typically through some form of docking keyboard or exotic hinge mechanism. These machines have always been better laptops than they were tablets due to the weaknesses of Windows interfaces of old.
Windows 8 lets these machines become truly useful. In their tablet guise, they have Metro apps (though these are currently a little thin on the ground). In their laptop guise they have full-strength desktop software. There are still rough edges. The integration of the two interfaces needs to be better. But Windows 8 works. It's one operating system that can support tablet and desktop apps side-by-side. And that might just be worth a little compromise.


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Intruder Arrested at Sandra Bullock's Homeby Thomas Chau | PopCrush
An intruder this morning was arrested at Sandra Bullock's house after he broke into the actress' property while she was home.
NBC Los Angeles reports that the Oscar winning actress was unhurt and that the man was arrested without incident around 6:30 a.m. PT.
The man's name has not been released yet but it was revealed that he was in his late 30s. Investigators are also looking into whether he was a stalker.
A rep for Bullock told PEOPLE that the 'Gravity' actress is "unharmed and is fine."
Last night, Bullock attended Spike TV's Guys Choice Awards where she was presented with the Decade of Hotness award. Past co-stars Hugh Grant and Keanu Reeves gave speeches before presenting Bullock with the award.
E! Online reports that Bullock accepted the award on stage and delivered a joke-filled thank you speech. The 49-year-old actress said, "I feel like I'm at my funeral. Decade of Hotness…My question was what decade? I have several under my belt. It should really be Decade of Hot Mess. That I can own and I do that well and I'm still convinced I'm up here because someone dropped out and they needed someone quickly and we know I'm home on Saturdays."
The 2014 Guys' Choice Awards will air on Spike TV on Wednesday, June 11.


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Many people are raising their own food to save
Unfazed by losing her vegetable crop to a freeze last year, Debbie McNeill is more than just gearing up.
The 49-year-old Haslet housewife is upping the stakes, putting down twice as many tomato, onion and jalapeño plants in a 15-by-15-foot raised garden at her mother's home "because it's fun and because of the economy."
McNeill is not alone.
From seed producers and greenhouse growers to retailers, all are reporting booming sales. All attribute it largely to family financial issues.
"This happens every time we have a downturn in the economy," said Rick Archie, the third-generation owner of Archie's Gardenland on the west side of Fort Worth, founded during in 1934. He estimates that vegetable plant sales have increased 20 to 25 percent so far this year.
At Russell Feed in Haltom City, manager Carl Cathey reports that his vegetable plant sales have soared 50 to 60 percent this year.
"Of course, a lot of it are replacements for people who got frosted out and came back for more," Cathey conceded. "But all in all, people seem just hungry to grow vegetables. Seeds are just now starting to move, but they're up about 20 percent in the last couple of weeks."
Seed companies recognized the market demand.


text: This week ADAC, the German auto club, tried to convince automakers to consider small car crash compatibility when designing larger cars by obliterating a Fiat 500 with an Audi Q7. The point ADAC was trying to make is not that the Fiat 500 is unsafe — it actually scores five stars in Euro NCAP testing where the Audi Q7 only garners 4. Rather, the really awesome, slow-motion crash footage is intended to encourage automakers to engineer big cars with small-car crash survivability in mind. We don't know if it'll work, but you can just keep sending out crash test videos, ADAC. We'll keep scoring them to The Blue Danube. [Drive]


text:
Internet Librarian: Collaborating to Demonstrate Value
Collaborating to Demonstrate Value
Margaret Hazel, Louise Alcorn, Erik Bobilin
Margaret started by talking about her work with the City of Eugene as the Technology Manager for the City's Library. Their city's budget goals and framework are based on three goals – getting to a sustainable budget, maintaining services to citizens, and not laying people off. Brainstorming with the whole organization about what the City could do to work smarter. Some ideas – stop serving food at city meetings, look for expertise in-house instead of contracting out, promote cooperation across departments and divisions. The library intranet is City-facing. It's encouraged City staff to reach out to the library staff for information and help. Their tag line is "What do you want to know today?" They have links for library cards for employees, links to the library's online resources and services, etc. They did a dog and pony show for the different departments about how the library can help them with their work. They discovered that departments had been paying for article access that the library could also provide to them for free (saving the other departments $ again). Some of the research they've done for other departments – police funeral and mourning traditions, copyright permission info, commercial food waste programs, local aerial historical photos, search alerts for local mentions. They've had 30 research questions of varying complexity come from the different departments over the last year.
Erik talked about his work at the Brooklyn Public Library. Their budget went from great in 2007 to awful from 2008 on. They focused in their budget discussions with the city on loss of programs, collections, etc. They didn't focus initially on how it would negatively affect other city departments' abilities to do their jobs. They hadn't really taken an outcomes based approach before, and they had to think about how they were marketing themselves and offering meaningful experiences. They worked on the diversity visa lottery in 2006 – a literacy program, computer basics classes, etc. They did something called the Skills Training and Employment Project, part of WorkForce1—a mayoral initiative, kind of like a city-funded temp agency. They started creating programs with FINRA, a group trying to help communities in Brooklyn that were hit by the recession really hard. Lessons learned: own the content, and access is not enough anymore. They've partnered with the city on additional jobs initiatives. A big partnership is the MyLibraryNYC project – a partnership between the New York City Libraries (Queens, Brooklyn, & NYPL) and the Department of Education. They're going to have one unified interface to their catalogs now and allow for inter-library delivery of items between public and school libraries. Great stuff! They've had much better budget discussions as a result of the additional partnerships they've had with the city. Now they have tangible outcomes that connect library services with organizational values.
Louise closed off the panel by talking about a web design project for her city. There were 13 city departments represented on the web committee, only one of whom had web experience (Louise, the librarian, of course). She took the opportunity to project manage the entire web project, got everyone to agree on the design and color schemes, navigation, etc. No shouting matches, no back room conniving, no back-stabbing. Library staff were then perceived as a knowledge resource for future projects. For example, she trained people on the city's new help desk software system.


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text:
Summary: ADP-ribosyl cyclase
Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.
This is the Wikipedia entry entitled "BST1". More...
The Wikipedia text that you see displayed here is a download from Wikipedia. This means that the information we display is a copy of the information from the Wikipedia database. The button next to the article title ("Edit Wikipedia article") takes you to the edit page for the article directly within Wikipedia. You should be aware you are not editing our local copy of this information. Any changes that you make to the Wikipedia article will not be displayed here until we next download the article from Wikipedia. We currently download new content on a nightly basis.
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BST1 Edit Wikipedia article
ADP-ribosyl cyclase 2 is an enzyme that in humans is encoded by the BST1 gene.[5][6]
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population.[6]
See also
- ^ a b c GRCh38: Ensembl release 89: ENSG00000109743 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029082 - Ensembl, May 2017
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ Kaisho T, Ishikawa J, Oritani K, Inazawa J, Tomizawa H, Muraoka O, Ochi T, Hirano T (Jul 1994). "BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth". Proc Natl Acad Sci U S A. 91 (12): 5325–9. PMC 43987 . PMID 8202488. doi:10.1073/pnas.91.12.5325.
- ^ a b "Entrez Gene: BST1 bone marrow stromal cell antigen 1".
External links
- Human BST1 genome location and BST1 gene details page in the UCSC Genome Browser.
Further reading
- Ortolan E, Vacca P, Capobianco A, et al. (2003). "CD157, the Janus of CD38 but with a unique personality.". Cell Biochem. Funct. 20 (4): 309–22. PMID 12415565. doi:10.1002/cbf.978.
- Lee BO, Ishihara K, Denno K, et al. (1996). "Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis.". Arthritis Rheum. 39 (4): 629–37. PMID 8630113. doi:10.1002/art.1780390414.
- Kajimoto Y, Miyagawa J, Ishihara K, et al. (1996). "Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity.". Biochem. Biophys. Res. Commun. 219 (3): 941–6. PMID 8645283. doi:10.1006/bbrc.1996.0327.
- Okuyama Y, Ishihara K, Kimura N, et al. (1997). "Human BST-1 expressed on myeloid cells functions as a receptor molecule.". Biochem. Biophys. Res. Commun. 228 (3): 838–45. PMID 8941363. doi:10.1006/bbrc.1996.1741.
- Muraoka O, Tanaka H, Itoh M, et al. (1997). "Genomic structure of human BST-1.". Immunol. Lett. 54 (1): 1–4. PMID 9030974. doi:10.1016/S0165-2478(96)02633-8.
- Wimazal F, Ghannadan M, Müller MR, et al. (2000). "Expression of homing receptors and related molecules on human mast cells and basophils: a comparative analysis using multi-color flow cytometry and toluidine blue/immunofluorescence staining techniques.". Tissue Antigens. 54 (5): 499–507. PMID 10599889. doi:10.1034/j.1399-0039.1999.540507.x.
- Yamamoto-Katayama S, Sato A, Ariyoshi M, et al. (2001). "Site-directed removal of N-glycosylation sites in BST-1/CD157: effects on molecular and functional heterogeneity.". Biochem. J. 357 (Pt 2): 385–92. PMC 1221964 . PMID 11439087. doi:10.1042/0264-6021:3570385.
- Liang F, Qi RZ, Chang CF (2001). "Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibroblasts.". FEBS Lett. 506 (3): 207–10. PMID 11602246. doi:10.1016/S0014-5793(01)02912-X.
- Yamamoto-Katayama S, Ariyoshi M, Ishihara K, et al. (2002). "Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities.". J. Mol. Biol. 316 (3): 711–23. PMID 11866528. doi:10.1006/jmbi.2001.5386.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Funaro A, Ortolan E, Ferranti B, et al. (2005). "CD157 is an important mediator of neutrophil adhesion and migration.". Blood. 104 (13): 4269–78. PMID 15328157. doi:10.1182/blood-2004-06-2129.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. PMID 15815621. doi:10.1038/nature03466.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. PMC 1850943 . PMID 16335952. doi:10.1021/pr0502065.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|This membrane protein–related article is a stub. You can help Wikipedia by expanding it.
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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
ADP-ribosyl cyclase Provide feedback
ADP-ribosyl cyclase EC:22.214.171.124 (also know as cyclic ADP-ribose hydrolase or CD38) synthesises cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion.
Literature references
Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD; , Nat Struct Biol 1996;3:957-964.: Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38. PUBMED:8901875 EPMC:8901875
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR003193
CD38, the HUGO gene name, is also called T10 or ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC). CD38 is a novel enzyme capable of catalysing multiple reactions, including NAD glycohydrolase, ADP-ribosyl cyclase, cyclic ADP ribose hydrolase and base-exchange activities. Two of the enzymatic products, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), are calcium messengers in a wide variety of cells from protist, plant, and mammal to human. CD38 is a positive and negative regulator of cell activation and proliferation, depending on the cellular environment. It is involved in adhesion between human lymphocytes and endothelial cells and is involved in the metabolism of two calcium messengers, cADPR and NAADP.
CD157 (also called BP-3/IF-7, BST-1 or Mo5) has ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities. CD157 supports the growth of a pre-B cell line, DW34. Anti-CD157 mAb IF-7 has synergistic effects on anti-CD3-induced growth of T progenitor cells, and facilitates the development of [alpha][beta] TCR+ cells in foetal thymic organ culture system.
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function
|NAD+ nucleosidase activity (GO:0003953)
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
The graphic that is shown by default represents the longest sequence with a given architecture. Each row contains the following information:
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- a link to the page in the Pfam site showing information about the sequence that the graphic describes
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
Note that you can see the family page for a particular domain by clicking on the graphic. You can also choose to see all sequences which have a given architecture by clicking on the Show link in each row.
Finally, because some families can be found in a very large number of architectures, we load only the first fifty architectures by default. If you want to see more architectures, click the button at the bottom of the page to load the next set.
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Pfam Clan
This family is a member of clan Nribosyltransf (CL0498), which has the following description:
This superfamily includes the N-deoxyribosyltransferase and ADP-ribosyl cyclase-like families as well as the family that includes the hypothetical protein PA1492 for which the structure is known. PA1942 has a very similar putative active site and is predicted by SCOP to have a deoxyribosyltransferase activity [1].
The clan contains the following 6 members:DUF1937 DUF4406 Nuc_deoxyri_tr2 Nuc_deoxyri_tr3 Nuc_deoxyrib_tr Rib_hydrolayse
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
There are various ways to view or download the sequence alignments that we store. We provide several sequence viewers and a plain-text Stockholm-format file for download.
Alignment types
We make a range of alignments for each Pfam-A family:
- seed
- the curated alignment from which the HMM for the family is built
- full
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- UniProt
- alignment generated by searching the UniProtKB sequence database using the family HMM
- alignment generated by searching the NCBI sequence database using the family HMM
- meta
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
- jalview
- a Java applet developed at the University of Dundee. You will need Java installed before running jalview
- an HTML page showing the whole alignment.Please note: full Pfam alignments can be very large. These HTML views are extremely large and often cause problems for browsers. Please use either jalview or the Pfam viewer if you have trouble viewing the HTML version
- PP/Heatmap
- an HTML-based representation of the alignment, coloured according to the posterior-probability (PP) values from the HMM. As for the standard HTML view, heatmap alignments can also be very large and slow to render.
You can download (or view in your browser) a text representation of a Pfam alignment in various formats:
- Selex
- Stockholm
You can also change the order in which sequences are listed in the alignment, change how insertions are represented, alter the characters that are used to represent gaps in sequences and, finally, choose whether to download the alignment or to view it in your browser directly.
You may find that large alignments cause problems for the viewers and the reformatting tool, so we also provide all alignments in Stockholm format. You can download either the plain text alignment, or a gzipped version of it.
View options
We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
|Representative proteomes
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
Format an alignment
Download options
We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
|Representative proteomes
|Raw Stockholm
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
If you find these logos useful in your own work, please consider citing the following article:
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
|Seed source:
|Pfam-B_3719 (release 5.2)
|Previous IDs:
|Sequence Ontology:
|Bateman A , Mian N
|Number in seed:
|Number in full:
|Average length of the domain:
|196.50 aa
|Average identity of full alignment:
|35 %
|Average coverage of the sequence by the domain:
|77.92 %
HMM information
|HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
|Model details:
|Model length:
|Family (HMM) version:
|download the raw HMM for this family
Species distribution
Sunburst controlsHide
Weight segments by...
Change the size of the sunburst
Colour assignments
|Other sequences
|Unclassified sequence
Align selected sequences to HMM
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
This chart is a modified "sunburst" visualisation of the species tree for this family. It shows each node in the tree as a separate arc, arranged radially with the superkingdoms at the centre and the species arrayed around the outermost ring.
How the sunburst is generated
The tree is built by considering the taxonomic lineage of each sequence that has a match to this family. For each node in the resulting tree, we draw an arc in the sunburst. The radius of the arc, its distance from the root node at the centre of the sunburst, shows the taxonomic level ("superkingdom", "kingdom", etc). The length of the arc represents either the number of sequences represented at a given level, or the number of species that are found beneath the node in the tree. The weighting scheme can be changed using the sunburst controls.
In order to reduce the complexity of the representation, we reduce the number of taxonomic levels that we show. We consider only the following eight major taxonomic levels:
- superkingdom
- kingdom
- phylum
- class
- order
- family
- genus
- species
Colouring and labels
Segments of the tree are coloured approximately according to their superkingdom. For example, archeal branches are coloured with shades of orange, eukaryotes in shades of purple, etc. The colour assignments are shown under the sunburst controls. Where space allows, the name of the taxonomic level will be written on the arc itself.
As you move your mouse across the sunburst, the current node will be highlighted. In the top section of the controls panel we show a summary of the lineage of the currently highlighed node. If you pause over an arc, a tooltip will be shown, giving the name of the taxonomic level in the title and a summary of the number of sequences and species below that node in the tree.
Anomalies in the taxonomy tree
There are some situations that the sunburst tree cannot easily handle and for which we have work-arounds in place.
Missing taxonomic levels
Some species in the taxonomic tree may not have one or more of the main eight levels that we display. For example, Bos taurus is not assigned an order in the NCBI taxonomic tree. In such cases we mark the omitted level with, for example, "No order", in both the tooltip and the lineage summary.
Unmapped species names
The tree is built by looking at each sequence in the full alignment for the family. We take the name of the species given by UniProt and try to map that to the full taxonomic tree from NCBI. In some cases, the name chosen by UniProt does not map to any node in the NCBI tree, perhaps because the chosen name is listed as a synonym or a misspelling in the NCBI taxonomy.
So that these nodes are not simply omitted from the sunburst tree, we group them together in a separate branch (or segment of the sunburst tree). Since we cannot determine the lineage for these unmapped species, we show all levels between the superkingdom and the species as "uncategorised".
Since we reduce the species tree to only the eight main taxonomic levels, sequences that are mapped to the sub-species level in the tree would not normally be shown. Rather than leave out these species, we map them instead to their parent species. So, for example, for sequences belonging to one of the Vibrio cholerae sub-species in the NCBI taxonomy, we show them instead as belonging to the species Vibrio cholerae.
Too many species/sequences
For large species trees, you may see blank regions in the outer layers of the sunburst. These occur when there are large numbers of arcs to be drawn in a small space. If an arc is less than approximately one pixel wide, it will not be drawn and the space will be left blank. You may still be able to get some information about the species in that region by moving your mouse across the area, but since each arc will be very small, it will be difficult to accurately locate a particular species.
Tree controlsHide
Download tree
- Save a text representation
Selected sequences
- (Uncheck all)
- graphically
- as an alignment
- sequence accessions
- sequences in FASTA format
The tree shows the occurrence of this domain across different species. More...
Species trees
We show the species tree in one of two ways. For smaller trees we try to show an interactive representation, which allows you to select specific nodes in the tree and view them as an alignment or as a set of Pfam domain graphics.
Unfortunately we have found that there are problems viewing the interactive tree when the it becomes larger than a certain limit. Furthermore, we have found that Internet Explorer can become unresponsive when viewing some trees, regardless of their size. We therefore show a text representation of the species tree when the size is above a certain limit or if you are using Internet Explorer to view the site.
If you are using IE you can still load the interactive tree by clicking the "Generate interactive tree" button, but please be aware of the potential problems that the interactive species tree can cause.
Interactive tree
For all of the domain matches in a full alignment, we count the number that are found on all sequences in the alignment. This total is shown in the purple box.
We also count the number of unique sequences on which each domain is found, which is shown in green. Note that a domain may appear multiple times on the same sequence, leading to the difference between these two numbers.
Finally, we group sequences from the same organism according to the NCBI code that is assigned by UniProt, allowing us to count the number of distinct sequences on which the domain is found. This value is shown in the pink boxes.
We use the NCBI species tree to group organisms according to their taxonomy and this forms the structure of the displayed tree. Note that in some cases the trees are too large (have too many nodes) to allow us to build an interactive tree, but in most cases you can still view the tree in a plain text, non-interactive representation. Those species which are represented in the seed alignment for this domain are highlighted.
You can use the tree controls to manipulate how the interactive tree is displayed:
- show/hide the summary boxes
- highlight species that are represented in the seed alignment
- expand/collapse the tree or expand it to a given depth
- select a sub-tree or a set of species within the tree and view them graphically or as an alignment
- save a plain text representation of the tree
Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.
There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Rib_hydrolayse domain has been found. There are 194 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
Loading structure mapping...


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Why do CEP supporters say their piece, accuse everyone of being against them, then leave?
If I was of the mind that I was on solid ground and others were wrong, I would make my point with facts and explanation, not innuendo and heresay, and I would stand my ground. I guess that is why our site is accused of "bashing" the CEP.
The CEP has obviously adopted Ghandi's methodology of no resistance on this site. So, if anyone says anything bad, the CEP just point at us and nods knowingly, calling us employer driven.
Don't be that gullible people, learn for yourselves and make your voice heard.
If past performance is any indication, (my experience that is, and Telus people back me up) the union will bring forth this proposal, sweating profusely, claim they fought and fought, but were vanquished by their evil foe.
The evil empire of SEPH will not budge, and they the benevolent CEP do not recommend its acceptance. They did their best, now the SEPH and their disciples are going to slit the collective throats of the community of PH by signing this disgusting pact with the devil cunningly disguised as a collective agreement.
If I am wrong, I will happily apologize for this statement… let's see.
Hey everyone. I got some time to do the latest update to the board software, but it meant that all the old modifications and styles wouldn't work anymore. So, here you have the newest iteration of LabourTalk. Please let me know by Private Message if you run into any issues with the new styling. Some new features on the board are:
We hope you like the changes!
- Latest HTML5 Responsive Styling - You can now see a new, more modern styling on the board. Along with this, you can resize the browser to see the board change with it. The board is now functional on all sizes of screens, including your cell phone, table and desktop/laptop.
- Post Sharing - Although you could previously, the new layout means the sharing icons are more visible on the lower right hand corner of each post. Click your favourite social media outlet to share the desired post with them.
- Multiple Themes - Previously there was only one theme in an attempt to lower the workload when modifications were put in place. Fortunately, the new modification system is much simpler to implement and we now have multiple colour options for you to enjoy. You can change these from your User Control Panel under the Board Settings heading.
- Announcements - Announcements can now be posted here (where you're seeing this one) and, in most cases, can be dismissed. To dismiss them, please click the "X" in the top right corner of this box.
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I am NOT CEP
For CEP supporters - Tell us your side of the story.
- Rookie Poster
- Posts: 73
- Joined: Fri May 19, 2006 11:39 am
Why should I go without simply because someone else decided to reject an offer knowing the consequences. I don't have the option to sit at home, I work or I lose my job.The posting of pictures is not for harassment or intimidation. It's to reveal those who have a lack of respect for the basic issues of survivial. It's information and a non-violent method of deterrment .
Management ran the boiler during the winter, no unionized employees have been onsite since the lockout.During the winter months, union personnel worked in the mill behind the picket lines to make sure nothing froze or was damaged because of the weather. Once the weather turned mild, they came out of the mill.
The letters you speak of were written to a member of the executive running for the NDP. The concerns by this staff person were sent privately to Mr. Murphy (candidate for MLA) and HE decided that this personal letter should be posted in the union hall for all to see - no doubt with the intention of having this staff member harassed by other union members. Is this how all his constituents will be treated if Mr. Murphy is unhappy with their comments or questions? It was a complete lack of professionalism from Mr. Murphy and it is no surprise that the staff member shot back in the public arena as Mr. Murphy chose that forum himself.Management personnel have written letters to the editor harassing union memebers and have even sent personal e-mails to workers under their supervision and have questioned their right to take part in the democratic process of our provincial election.
I would be curious to see all of the postings from the union supporters in one thread so that we can see what has been contributed to date (hint ). You may find that little has been provided to support their positions, merely statements that the company lies etc... Can you blame us for not being swayed by the arguments?I know you're all looking for the whole picture, but I've come to the conclusion that your minds are made up even before , and will not change even after. So that's it for me on this forum.
- Ash
- Site Wannabe Administrator
- Posts: 1604
- Joined: Mon Aug 29, 2005 9:11 pm
- Location: Calgary
- Contact:
Apparently they think the point of debate and discussion is to win everyone over to their side, which is incorrect as it isn't a contest. Its not about winning or losing, its about understanding. The point and purpose of such a discussion is to bring to light the issues that both sides think is important, and to understand where each other is coming from.Why do CEP supporters say their piece, accuse everyone of being against them, then leave?
"Shop smart. Shop S-Mart."
"Shop smart. Shop S-Mart."
- Ash
- Site Wannabe Administrator
- Posts: 1604
- Joined: Mon Aug 29, 2005 9:11 pm
- Location: Calgary
- Contact:
- dante666
- Experienced Poster
- Posts: 252
- Joined: Wed Nov 02, 2005 3:18 pm
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- Ash
- Site Wannabe Administrator
- Posts: 1604
- Joined: Mon Aug 29, 2005 9:11 pm
- Location: Calgary
- Contact:
Thank you my evil minion! Your adoration is well deserved.Awww you guys are so kind when you talk about my hero Ash like that!!!!
I can't help but worship the guy! He's awesome!
Keep the praises going! He never gets tired of them!
I hereby reward you with an extra spoonful of gruel for supper.
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text:
The latest Dante's Inferno trailer provides us with a quick recap of the sins of man - lust, gluttony, greed, anger, heresy, violence, fraud, treachery, and using leetspeak. I might have made up one of those.
It's a lovely trailer and all, but I can't help but wonder what changes Dante Alighieri would have made to his sin lineup had he written The Divine Comedy today. Would there be a circle for people who spoil the endings to movies? People who talk loudly on their cell phones in public? Folks who hold up the line at Starbucks? Perhaps back then it was easy to limit things to nine circles, but like a tree, I suspect hell has developed a few new ones since then. Somebody get that man a Spirograph.


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Subscribe To Saints Row 4 Collector's Edition Includes Dubstep Gun Updates
I've already subscribed
Deep Silver has announced a Collector's Edition, or Super Dangerous Wub Wub Edition, of Saints Row 4. The $99 bundle will include a 12-inch replica of the in-game Dubstep Gun.
The Dubstep Gun causes SR4 characters in its path to dance uncontrollably. The replica doesn't possess that kind of mind control power. However, it can play music and it's got a laser sight. You've hung worse things on your mantle. The gun is accompanied by a Dubstep Doomsday Button will let you summon the wub wub's from the comfort of your desk.
The third item in the CE is an 8-inch statue of Johnny Gat. Gat is a legendary member of the Third Street Saints who was slain earlier in the series. Now that the Saints are in the White House, perhaps they'll actually build this statue in the game world.
The full contents of the Commander-in-Chief Edition are also included. The C-in-C bundle provides a bonus weapon, vehicle and costume. All pre-order customers receive this content for free.
SR4 will debut worldwide in August.


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Vladimir Sobotka Lifts Blues Past Wild in OT
ST. LOUIS (AP) - Vladimir Sobotka scored from close range at 2:16 of overtime to give the St. Louis Blues a 5-4 victory over the Minnesota Wild on Sunday night
St. Louis is 5-1, its best start since winning seven of its first eight in 1997-98. Coming off a 4-3 victory in Dallas on Saturday night, the Blues improved to 3-0 at home.
Minnesota's Dany Heatley forced the overtime, tying it at 4 when he batted the puck out of the air with 4:08 left in regulation for his fourth goal of the season. The Wild have lost three straight.
Chris Stewart, Barret Jackman, Wade Redden and Patrik Berglund also scored for St. Louis, and Brian Elliott, getting his first home start, made 12 saves.
Zach Parise had two goals and an assist for Minnesota after also scoring twice in the Wild's 5-3 loss in Detroit on Friday night. Mikko Koivu added a goal, and Niklas Backstrom stopped 32 shots.


text:
Fontaines D.C.
O2 Institute, Birmingham.
14+ only. 14s to 15s must be accompanied by an adult. No refunds will be given for incorrectly booked tickets.
More information about Fontaines D.C. tickets
The HMV Institute takes the needs of disabled customers very seriously and
actively encourages people of all abilities to attend the events scheduled at
their venue.
Though built at the turn of the 1900's, the building has been modernized to
allow wheelchair access via front of house (please note there is no backstage
disabled access). Due to Health and Safety Assessments, we regret the number
of wheelchairs that we can admit to the building is limited.
In order to ensure that all disabled patrons to the HMV Institute are
adequately catered for, we request that in advance of ticket purchase all
disabled customers contact the venue to explain the nature of the disability.
Please email firstname.lastname@example.com or call 0121 643 0428. The telephone line
opens at 11am and closes at 5pm and operates Monday to Friday. Please do not
call outside of these hours as you will be asked to call back. Please note
that no other query can be dealt with on this number.
On the evening of an event, we do advise disabled customers to arrive at the
venue 15 minutes prior to doors, ideally accompanied by a companion over 18
years old who will be admitted free of charge.
The free companion ticket is available to patrons who are registered disabled.
Both the ticket to be paid for and the free companion ticket needs to be
booked in advance.
Please email firstname.lastname@example.com for specific requests, enquiries or
comments regarding access/personal needs and a member of our team will
endeavour to accommodate such requirements.


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Here you can find answers to questions about how the board works. Use the links or search box below to find your way around.
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text:
Zoomcar Mangalore Coupons: Flat 15% Off Code on Sedans & SUVs + Flat Rs 250 CashKaro CashbackHide Details
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text:
Game #53: White Sox at Blue Jays pregame
Chicago (24-24) at Toronto (24-28)
at 7:07 p.m. ET at the Rogers Centre
Today's lineups:
Darin Erstad, CF
Tadahito Iguchi, 2B
Jim Thome, DH
Jermaine Dye, RF
Paul Konerko, 1B
A.J. Pierzynski, C
Joe Crede, 3B
Rob Mackowiak, LF
Juan Uribe, SS
PITCHING: LHP Mark Buehrle
Alex Rios, RF
Lyle Overbay, 1B
Vernon Wells, CF
Troy Glaus, 3B
Frank Thomas, DH
Aaron Hill, 2B
Adam Lind, LF
Sal Fasano, C
John McDonald, SS
PITCHING: RHP Roy Halladay
NOTES: Hallday is making his first start since May 10 and is coming off the 15-day DL after undergoing an emergency appendectomy on May 11. … Halladay's next win will be the 100th of his career. … From 2002-06, Buehrle and Halladay ranked one and two in quickest time of game among MLB starters. … SS Royce Clayton (left foot injury) missed his second game in a row after fouling a ball off his foot, but was available off the bench. … The hot topic around the Rogers Centre was still A-Rod's controversal ninth-inning shout during Wednesday night's game. Check the Jays notes on bluejays.com later for more follow up.
5 Comments
Matt Stairs should be in the lineup almost every day until Reed gets back. He is obviously on fire with the bat right now.
What gibby is doing right now does not make any sense. He'll play Lind two straight days, while he promptly goes 0-8. Then Stairs comes in the lineup and hits a home run. And then sits another couple games.
For those who will defend this with a "developing player" argument, I think it is a little early to give up on this season. Come August, if we still can't do anything I have no problem with sitting guys like Stairs. But for now, while his bat is hot, he should be in the lineup.
I do agree that since Stairs is hot play him, if not in Left then DH
I agree to…I've expressed this feeling for some time now…I undestand that Lind did good things right out of spring training and last year but nows not the time to give him at bats to regain what he had. Stairs is doing great and might even be the most productive player in the line up right now if he played consistenly. Gibbons is making some very backwards decisions right now..I like the guy but he doesnt make sense sometimes.
5 games out of the wildcard is enough reasoning to keep Stairs in for more games than he should. This team still has a pretty legitimate chance and unlike Seattle, Baltimore and even Minnesota, has the pitching to sustain a run. (or so we hope).
However, should the team fail to close that wildcard gap, Lind must be played 80% of the time. Stairs isn't the star slugger of the future, Adam Lind is. Even now, if you can't get him at-bats, it may be necessary to send him down so he can. The short term advantage of having Stairs over Lind does not necessarily equate the long-term problem of Lind not develpoing on schedule.
Well, by the looks of things, Stairs will be in the lineup a bit more. But so will Lind. With Overbay gone, we lose a pretty good bat, but at least this will give both Stairs and Lind the at bats that they need. Just hate to lose a guy like Overbay. For what he's been missing this year in hitting, he's definitely been good on D.


text:
Strict controls on the sale of cigarettes to youth may also reduce adult smoking, a new study suggests.
States with tighter restrictions on the sale of cigarettes to teens also had lower adult smoking rates, especially among women, researchers found. These states also tended to have fewer adult heavy smokers.
"In most states for many years, it has been illegal to sell cigarettes to people under 18, but few provisions are in place to prevent those sales," study first author Richard Grucza, an associate professor of psychiatry at Washington University School of Medicine in St. Louis, said in a university news release. "This study shows that more restrictive policies can prevent teen smoking and be beneficial down the road."
He and his colleagues examined 1998 to 2007 data from more than 105,000 people, aged 18 to 34, involved in an ongoing U.S. National Cancer Institute survey that monitors smoking behavior throughout the country. They looked at whether people had ever smoked, whether they were current smokers and, if they did smoke, whether they smoked more than 10 cigarettes a day.
The researchers focused on nine smoking-related policies. In states with stricter rules and enforcement, 17-year-olds had more difficulty buying cigarettes and were less likely to smoke when they were in their 20s and 30s, according to the study published online June 13 in the American Journal of Health.
"We estimated that if all states had effective policies in place, it would reduce the prevalence of smoking by about 14 percent and the rates of heavy smoking by 29 percent," Grucza said.
The study found that the following were the four most effective restrictions:
- Eliminating cigarette vending machines or placing them in locations inaccessible to those under 18
- ID requirements for purchasing cigarettes
- Restrictions on repackaging cigarettes to prevent five or 10 being sold at a time, rather than the whole 20-cigarette pack
- Banning distribution of free cigarettes at public events
"A lot of states still have not adopted all of these policies. In 2006, which is the last year for which we have data, only four states required a photo ID, and only 20 states had any kind of identification requirements at all. So there's still a lot of room for improvement," Grucza noted.
However, as more states implement and enforce more restrictive antismoking policies, there may be further reductions in smoking rates, he added.
Source: Washington University School of Medicine, via HealthDay


text:
Sony Mobile Communications
The UK weather today is cold and wet – you could say it's a perfectly normal British Summer day…
But, despite a gloomy start to the week, we're excited to tell you about something cool we're kicking-off today – how YOU can accelerate the next Xperia smartphone public announcement.
Simply head on over to our global Facebook page and click the button to fast forward time and bring our announcement nearer – you can interact once a day (bringing our reveal a little closer each time) and share with friends to help speed things along!
You can also unlock secret competitions to win the next Xperia _____ 😉
So hurry, the power really is in your hands and that clock's ticking!


text:
The 1998 Induction Weekend Celebration kicked off on Friday with a special
appearance by former New York Islanders sniper Mike Bossy. Both young and
old came out for this rare opportunity to meet one of hockey's greatest
goal scorers.
Saturday was Kodak Photo and Fan Forum day at the Hall of Fame, which
meant there were numerous prizes given away. The grand prize went to Jim
Hutton of Scarborough, winning a weekend at the Royal York Hotel, 2 ticket's
to Saturday's Leaf game and 2 ticket's to the Induction Gala. Excitement
filled the air as five honoured members, representing 26 Stanley Cup championships,
each spent time in a question/answer session led by the FAN 590's Gord
Stellick. Yvan Cournoyer, Red Kelly, Pierre Pilote, Steve Shutt and Gerry
Cheevers brought back some great memories of a by-gone era, reminiscing
about former teammates, favourite memories and Stanley Cup victories. Then,
each relieved their glory days, posing with various fans and Lord Stanley's
Finally, the big day arrived. The Hall was closed to the
public on Monday, as preparations were in full force for
the evening's gala event. During this time, a luncheon was being
held to honour the newest Media Award winners. After 34 years of
covering the Montreal Canadiens, Yvon Pedneault was voted the winner
of the Elmer Ferguson Memorial Award for his contributions to the
print media.
At 6 p.m. the doors were opened and guests began to arrive. Two radio
stations set-up with live spots, the FAN 590 from Toronto and CHRC 80 from
Quebec City. With an exquisite buffet and plenty of drinks available, both
stations relived a little nostalgia, interviewing the likes of Ted Lindsay,
Bill Gadsby, Ted Kennedy and Johnny Bower.
1998 Inductees
Select A Topic
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text:
Complications of
strep throat are rare but can occur, especially if
strep throat is not properly treated with antibiotics. Complications can be
related either to the strep infection or to the body's
immune response to the infection.
Although rare, complications can result from the strep infection
spreading to other areas of the body. Infection can spread to the:
Other, more rare, complications include:
Sometimes in response to a strep infection, the body's immune
system will attack healthy tissues, causing complications such as
rheumatic fever, inflammation of the kidneys (glomerulonephritis), or pediatric autoimmune
neuropsychiatric disorders associated with streptococcal infections (PANDAS).
CitationsAmerican Academy of Pediatrics (2009). Group A
streptococcal infections. In LK Pickering et al., eds., Red Book: 2009 Report of the Committee on Infectious Diseases, 28th ed., pp.
616–628. Elk Grove Village, IL: American Academy of Pediatrics.
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Last Revised:
August 2, 2012
Healthwise Staff
Medical Review:
Kathleen Romito, MD - Family Medicine & Donald R. Mintz, MD - Otolaryngology
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