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Dallas heard that his father, grandfather and great-grandfather had all walked on water on their 21st birthdays.
So, on his 21st birthday, Dallas and his big brother Damon, headed out to the lake. "If they did it, I can too!" he insisted.
When Dallas and Damon arrived at the lake, they rented a canoe and began paddling. When they got to the middle of the lake, Dallas stepped off of the side of the boat... and nearly drowned.
Furious and somewhat embarrassed, he and Damon headed for home.
When Dallas arrived back at the family home, he asked his grandmother for an explanation. "Grandma, why can't I walk on water like my father, and his father, and his father before him?"
His sweet old grandmother took Dallas by the hand, looked into his eyes, and explained, "That's because your father, grandfather, and great-grandfather were born in January, You were born in June, dear."


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If you think you might be interested in law as a future career, but have little (or no) idea what that really involves, The Beginner's Guide to a Career in Law is for you. The guide has been designed with people like you in mind – on the one hand, we've assumed no prior knowledge, while on the other, we've assumed you'll have lots of questions. Within these pages you will find information about the job of a lawyer, the differences between the three main types of legal professional (solicitors, barristers and chartered legal executives), and the courses and training you need to complete in order to qualify. There is also a selection of key questions, a welcome reality check and – for those who want to find out more – ideas on some of the next steps to take. The Beginner's Guide is brought to you by LawCareers.Net (LCN), the number one resource for those interested in joining the legal profession. On the website you will find employer profiles; interviews with law firm recruiters, trainees, associates and partners; advice from LCN's resident agony aunt, the Oracle; blogs and videos from people at different stages of their legal careers; information on law courses (undergraduate and postgraduate); and a searchable database of training contract and pupillage vacancies.
Welcome to the first stage of your legal career!
Made with FlippingBook - Online magazine maker

subset: commoncrawl


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how can we say that point mutations alter synthesis of essential amino acids? - (Nov/04/2012 )
Hi there!
I am preparing for my viva about " point mutations in the BCR-ABL kinase domain of chronic myeloid leukemia (CML) patients"
I need some help about:
A common point mutation found in CML is M244V....as we know that our body can't synthesize essential amino acids. Where M (methionine) and V (valine) both are essential amino acids...
The question is that how can we claim that the normal codon was coding for "methionine" and after a mutation it started coding for "valine"? although both are essential amino acids....hesis
Do we write "M244V" just to represent the nucleotide altered behind ...or an actual change in amino acid synthesis?
Three dimensional structure prediction may give some clue. Note whether mutation is in functional region of protein or do it influence three dimensional structure overall.
but my concern is that when we say that our body cant produce essentil amino acids..then how we are talking about methionine alterations???
Just to clarify a few things..
Are you aware that genetic code ancodes the amino acid in a protein chain, that is taken from the pool of amino acids already present in a cell? The availability of the amino acids is not important for differences between normal and mutated protein. It's just there, methionine, valine, whatever. Essential only means body can't synthetise them and must take them from food, that's all. Unless there is serious starving, this doesn't change, and if there is one, all protein synthesis as whole is seriously affected. But probably before that, person would already die.
Now the mutation happens in DNA and changes the code, so that insted of methionine, valine is added, as the code says. There is bunch ov valines and methionines waiting, but only valine now gets a ticket.
Change in the amino acid sequence makes a different protein that has an altered function, in this case a mutation altering a kinase sensitivity to its inhibitor, that is used as a treatment for CML, so meaning worse prognosis for the patient.
Just please tell me you already knew that and just I either didn't understand the question or you wasn't clear enough in asking it... otherwise I would have to live with a finding that people exist, who are obviously supposed to have an exam from a Bcr-Abl mutations and probably CML pathology and they don't have a clue about how proteins work. Please, I desperately hope you'll prove me wrong..
There are amino acid that we can't synthethise at all, and those that we can, but may be not enought always.
But I still don't get why are you asking this regarding BCR-ABL and M244V. This mutation does not alter any methabolic pathway (it's a kinase, a signaling molecule) connected to amino acid synthesis or anything.
There is difference between protein synthesis - connecting the already present complete amino acids in cell together by peptide bond - and between amino acid synthesis - synthesis of the building blocks alone from some simple chemical structures (plus the fact that some bulding blocks you can't syntetise and need to get from food).
It's like you want to build houses from LEGO bricks, you have plan for a house and just add bricks together to build it. You need the free bricks pool, luckily you have a small factory, that can make some of them by pouring melted plastics into matrice, but some special bricks you can't make and you must get them regulary from a supplier. But that thing usually works fine.
If you have a mutation, it means a change in plan, you just use other brick than the original. That's all, it has nothing to do with the brick factory.
It's still obvious that there are still some concepts you are not aware of, since you wouldn't ask this way.. M244V by the way is a notation of a change of amino acid Methionine on the codon number 244 to Valine. But this protein change has to have it's origin in the DNA. This amino acid change is usually caused by single nucleotide substitution c.730A>G of guanine for adenine at possition of 730 of coding sequence.


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|After-school Clique, 4th-6th grades
Event Type: Program
Age Group(s): Children
Date: 12/18/2018
Start Time: 3:00 PM
End Time: 4:00 PM
Favorite books, new books, never-knew-existed books plus puzzles, games, crafts and more! Geared specifically for children in 4th grade through 6th grade. Snack provided.Sanibel Public Library
The public is invited to this Library Program. There is no registration required and no additional cost to participate.
Location: Children's Area
Contact: Deanna Evans
Contact Number: 2394722483
Presenter: Deanna Evans


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You've seen it, I've seen it, we've all seen it. But what exactly is "it"?
I'm talking about those "viral" quote images that people EVERYWHERE have been sharing on various social networks, blog posts, and all over the place for years now.
The funny thing about this is that a lot of people just share quotes that apply to them, whether it's on that given day, moment, or whatever.
Most of us don't care where the quote comes from, we just share it because it communicates for us.
It's similar to music in a way, except, well, it's with text, so it's actually transmitting a message.
Anyway, these images can range from super basic, to fancy and eye capturing. More importantly is that many marketers have taken advantage of this "viral" sharing approach with these kinds of images.
Nowadays, they're often referred to as "social posters" or some other fancy name. You may see them as bonuses for products, maybe in PLR packages, or anywhere else.
I often times see them on Pinterest. Not that I go on there or anything... HAHA!
Realistically though...
Whether it's on Facebook, Twitter, Pinterest, a blog, or anywhere else.
When you put them out there and tag them properly, maybe including a link back to your site, blog, product, or anything else - you plant the seed.
This seed then has the potential to grow when others passively share it across networks.
All of the hard work is being done for you, so you really just need one thing...
That thing is the "social poster" images, based around a specific topic.
And now, drum roll please...
That's where we here at "Viral Social Posters" come in and save the day like some kind of awkward nerdy internet marketing super heroes or something.
Alright, enough with my bad puns and jokes. It's time for the big reveal...
Viral Social Posters Present The...
We've done all of the hard work, hired top notch graphic designers, and prepared an awesome package of "Healthy Eating" based social poster images for you to use.
Better yet, you'll even receive the .PSD Photoshop source files as well. This means you can easily go in and modify any of the quotes in any way you'd like.
To top it all off, you ALSO get the "private label rights" license to this full package, plus some awesome reseller kit modules too.
You can use these images for yourself and your clients, OR you can resell them and keep every single cent or revenue that you earn.
When you truly think about it, the possiblities are MASSIVE with this kind of package. By leveraging our hard work, building an audience and generating viral traffic has NEVER been easier.
Of course, no sales page is complete without some sort of epic module breakdown that explains every aspect of the (PLR) package that you're receiving.
In this case, we really did want to explain everything in depth just so you understand what's going on.
So... wait no longer, because the entire breakdown of each of the 10 modules is right below.
Module # 1
100 Healthy Eating Based Social Posters
If you're looking for fresh content, especially content that you KNOW will generate real engagement (ie: images), then this is by far one of the easiest and quickest ways to do it.
You'll receive 100 (sometimes more with variations) social poster "quote" images in PNG file format. Each image will contain a different quote, and a stock (royalty-free) photo as the background scene.
Everything is clean, safe, and entirely ready to use right from the get go.
File Format(s) Included:
Module #2
100 PSD Photoshop Source Files
Want to edit any of these social posters? You can effortlessly do that because we've included all 100 PSD source files for the quotes.
This means you can change the font colors, font type, add a different image, brand it, or really do anything else that you'd like.
You could even make new social posters using the basis (templates) from these 100 posters.
File Format(s) Included:
Module # 3
100 Quotes In A Spreadsheet
With 100 quote images, you'll probably want to check out the various quotes in text format as well. This will allow you to utilize them in various ways.
We are including a nifty little spreadsheet packed full of every single quote and who said it.
This means you can include the text in your blog posts or where ever you choose to post these images.
File Format(s) Included:
Module #4
Professional Reseller Graphics Package
Making this product look even MORE professional and top notch, we went ahead and had our graphic designer whip up an absolutely beautiful minimalistic e-cover.
This cover graphic perfectly highlights the power and simplicity of this product, and you'll even receive editable source files and blank files so you can rebrand it however you'd like.
File Format(s) Included:
Module #5
Front End Sales & Thank You Pages
Considering that you can resell this graphics package and profit from it, as well as using it for your own traffic efforts - you need some assets to sell it.
What would a PLR package be without a completely done-for-you high quality sales page with effective sales copy and beautiful graphics?
And of course, we're including just that. Check out the preview of the sales page below. Better yet, we're including Darren's standardized "2-step" download page sequence as well. (It's all explained inside)
And the sales page has a bit more in between those two images. Plus you receive legal pages as well so that you can stay fully in the lines.
File Format(s) Included:
Module #6
'WOW' Sales Video & Voice Over
With the digital age, and everybody being wired to the Internet and constantly on the go, people don't really have the time to be reading through tons of text.
That's why we decided to put together a unique but highly effective explainer style sales video that is fully geared towards the topic of the product. Complete with a professional voice over as well.
You will be receiving a 1080p MP4 video file for the sales video. Furthermore, this sales video is already implemented into the sales page, so that saves you the hassle of doing it yourself.
File Format(s) Included:
Module #7
Swipes Kit For Reselling Package
Tying a lot of the promotional efforts together with this package, we felt that just providing "email swipes" was really skimping out.
That's why we went all out and decided to put together a kit of swipes that you can use for various methods of promotion.
All you have to do is determine which way you'd like to promote, assemble your swipe using the various pieces of the kit, and then proceed to post away.
File Format(s) Included:
Module #8
Camtasia Studio Video Project File
As another massive added value to this package, you'll also receive the Camtasia Studio Video Project File for the high def sales video.
What this means is that you can easily go in and edit the text, change the colors, add to it, hire for a new voice over, or do anything else you'd like.
This project file is yours to edit and modify however. And it's super easy to use.
File Format(s) Included:
Module #9
License Package
Not only will you receive the private label rights license that outlines everything that you CAN and CANNOT do with these images and this package, you'll get something even more.
You'll receive a professional written and elegantly formatted end user license agreement which is based around an extended (commercial) royalty-free license agreement.
You can provide this to your customers so that they know what their usage rights are with the images.
File Format(s) Included:
Module # 10
Step-by-Step Setup Guide
We're not going to send you out into the wild without a sense of what to do or where to go with this kind of super lucrative graphics package.
That's why Darren took the time to record a series of videos that will show you not only how to use these social posters, but also how to set up the reseller kit including the sales page, graphics, and uploading it to your web host as well.
You'll know exactly how to utilize this package and start benefitting from it immediately.
File Format(s) Included:
There's 100 images to choose from, and they cover all sorts of quotes, sayings, and even statistics related to the main topic. Meaning you should have no trouble find more than a few "social posters" to fit your audience.
Whether you have Adobe Photoshop (Paid) or GIMP (Free), you can easily add your name, website title, brand logo, or URL to any of these quote images. Heck, you can even use an online image editor if you'd like to do it that way. Or you can skip it!
This is perhaps the easiest step of the process. All you have to do is venture out to one of the many websites populated by people that will share your image. Simply post your quote image, add some relevant tags, add a link to your site, and enjoy.
Due to the nature of this product and being that it's both a graphics package and a PLR package, there will be no refunds available for this.
That means that all sales of this package are final. There are 100% no refunds.
Please view the details of this product carefully before making your purchase.
Putting together this entire package yourself, just the images, might end up costing you a pretty penny, not to mention finding the proper freelancers, organizing everything, and then bringing it all together as a product.
Just take a look at everything that's crammed into this awesome graphics based PLR package for you:
Instead of charging you an arm and a leg for this package, I've decided to let you in at the bottom dollar for a limited time. However, I don't plan to keep this offer open forever, because I don't want the content to become oversaturated around the web.
Because of that, I'm running a limited time dimesale. That means the price is low at the moment, and it's going to increase with every other sale until it hits a ceiling.
From there, I'll be gauging the number of sales, and when I hit a certain number, I'll pull this entire PLR package down from this page and it will be gone permanently.
Having said that, if you'd like to get in at the lowest possible price, have a ton of traffic generating images with tons of potential, and even receive a reseller kit for this package (so you can profit from your investment), then right now you have to make a decision.
Just one simple payment and you have this massive graphics package at your disposal to utilize again and again howver you see fit to benefit your efforts.
Are you ready to take action? We'll see you on the inside!
PS: This offer is only available for a limited time at the current pricing you see above. Furthermore, the PLR to this package is only going to be available during this time (and MAYBE a little bit after). So, you're looking to have an essentially evergreen graphics product at your disposal, whether to use or to resell - this is the deal.
You will receive PNG files for the actual social poster images themselves. Additionally, you'll receive the PSD Photoshop source files for each of the social posters as well, so that you can easily edit them.
Yes, you are permitted to modify these images in any way you see fit, whether by using the PSD files or not.
Due to the nature of this product being mostly images, and you being able to see the quality of the images clearly on this page, there are no refunds.
Yes, you can sell these social posters with personal use rights only. Whether as a whole or individually.
Absolutely, you will receive a license agreement that outlines what your usage rights are. You will also receive a license you can give to your customers too.
There's really no limit to where you can post them, examples are Facebook, Instagram, and Pinterest.
Yes, the images used in this entire package for the backgrounds or any icons, are indeed royalty-free or fully compensated for. Guaranteed!
No, the license you are receiving allows you to only distribute these images with personal use. You cannot distribute this package with resell rights in any way.
This is the bottom slider area. You can edit this text and also insert any element here. This is a good place if you want to put an opt-in form or a scarcity countdown.


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This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.
Langerhans cell histiocytosis is a disease that can damage tissue or cause lesions to form in one or more places in the body.
Langerhans cell histiocytosis (LCH) is a rare disease that begins in LCH cells (a type of dendritic cell which fights infection). Sometimes there are changes in LCH cells as they form. These changes may cause the LCH cells to grow and multiply quickly. This causes the LCH cells to build up in certain parts of the body, where they can damage tissue or form lesions.
LCH is not a disease of Langerhans cells that normally form in skin.
Scientists do not agree on whether LCH is a type of cancer or is a condition caused by a change in the immune system. LCH is mainly treated with anticancer drugs. Some of these drugs are also used to treat immune system conditions.
LCH may occur at any age, but is most common in young children. Treatment of LCH in childhood is different from treatment of LCH in adults. The treatments for LCH in children and adults are described in separate sections of this summary.
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with childhood Langerhans cell histiocytosis. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.
Family history and having a parent who was exposed to certain chemicals may increase the risk of LCH.
Anything that increases your risk of getting a disease is called a risk factor. Having a risk factor does not mean that you will get the disease; not having risk factors doesn't mean that you will not get the disease. Talk with your doctor if you think you may be at risk. Risk factors for LCH may include the following:
The cause of LCH is not known.
The signs and symptoms of LCH depend on where it occurs in the body.
These and other symptoms may be caused by LCH. Other conditions may cause the same symptoms. Check with your doctor if you have any of the following problems:
In infants, signs and symptoms of LCH may include:
In children and adults, signs and symptoms of LCH may include:
Signs and symptoms of LCH may include:
Lymph nodes and thymus
Endocrine system (including the pituitary gland)
Central nervous system
Liver and spleen
Bone marrow
Tests that examine the organs and body systems where LCH may occur are used to detect (find) and diagnose LCH.
The following tests and procedures may be used to detect (find) and diagnose LCH or conditions caused by LCH:
Certain factors affect prognosis (chance of recovery) and treatment options.
LCH in organs such as the skin, bones, lymph nodes, or pituitary gland usually gets better with treatment and is called "low- risk". LCH in the spleen, liver, or bone marrow is harder to treat and is called "high-risk".
The prognosis (chance of recovery) and treatment options depend on the following:
In infants up to one year of age, LCH may go away without treatment.
There is no staging system for Langerhans cell histiocytosis (LCH).
The extent or spread of disease is usually described as stages. There is no staging system for LCH.
Treatment of LCH is based on where LCH cells are found in the body and whether one or more body systems are affected.
LCH is described as single-system disease or multisystem disease, depending on how many body systems are affected:
LCH may affect low-risk organs or high-risk organs, depending on where it occurs in the body:
Recurrent Langerhans cell histiocytosis (LCH) is disease that has recurred (come back) after it has been treated. The disease may come back in the same place or in other parts of the body. It often recurs in the bone, ears, skin, or pituitary gland. LCH often recurs the year after stopping treatment. Recurrent LCH is also called reactivation.
There are different types of treatment for patients with Langerhans cell histiocytosis (LCH).
Different types of treatments are available for patients with LCH. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Whenever possible, patients should take part in a clinical trial in order to receive new types of treatment for LCH.
Clinical trials are taking place in many parts of the country. Information about ongoing clinical trials is available from the NCI Web site. Choosing the most appropriate treatment is a decision that ideally involves the patient, family, and health care team.
Children with LCH should have their treatment planned by a team of health care providers who are experts in treating this disease in children.
Treatment will be overseen by a pediatric oncologist, a doctor who specializes in treating children with cancer. The pediatric oncologist works with other pediatric healthcare providers who are experts in treating children with LCH and who specialize in certain areas of medicine. These may include the following specialists:
Some treatments for LCH cause side effects months or years after treatment has ended.
Some treatments cause side effects that continue or appear months or years after treatment has ended. These are called late effects. Late effects of treatment for LCH may include the following:
Some late effects may be treated or controlled. It is important to talk with your child's doctors about the possible late effects caused by some treatments.
Nine types of standard treatment are used:
LCH is usually treated with anticancer treatments. These treatments stop the LCH cells from growing and dividing.
Watchful waiting
Watchful waiting is closely monitoring a patient's condition without giving any treatment until symptoms appear or change.
Surgery may be used to remove LCH lesions and a small amount of nearby healthy tissue. Curettage is a type of surgery that uses a curette (a sharp, spoon-shaped tool) to scrape LCH cells from bone.
Radiation therapy
Radiation therapy is a treatment that uses high-energy x-rays or other types of radiation to kill cells or keep them from growing. External radiation therapy uses a machine outside the body to send radiation toward the LCH lesion.
Photodynamic therapy
Photodynamic therapy is a treatment that uses a drug and a certain type of laser light to kill cells. A drug that is not active until it is exposed to light is injected into a vein. The drug collects more in LCH cells than in normal cells. For LCH, laser light is shined onto the skin and the drug becomes active and kills the LCH cells. Photodynamic therapy causes little damage to healthy tissue. Patients who have photodynamic therapy should not spend too much time in the sun.
In one type of photodynamic therapy, called psoralen and ultraviolet A therapy (PUVA), the patient receives a drug called psoralen and then ultraviolet radiation is directed to the skin.
Chemotherapy is a treatment that uses drugs to stop the growth of cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly onto the skin or into the cerebrospinal fluid, an organ, or a body cavity such as the abdomen, the drugs mainly affect cells in those areas (regional chemotherapy).
Nitrogen mustard is a drug that is put directly on the skin to treat small LCH lesions.
Biologic therapy
Biologic therapy is a treatment that uses the patient's immune system to fight disease. Substances made by the body or made in a laboratory are used to boost, direct, or restore the body's natural defenses against disease. This type of treatment is also called biotherapy or immunotherapy.
Interferon is a type of biologic therapy used to treat LCH of the skin.
Targeted therapy
Targeted therapy is a type of treatment that uses drugs or other substances to find and attack LCH cells without harming normal cells. Imatinib mesylate is a type of targeted therapy called a tyrosine kinase inhibitor. It stops blood stem cells from turning into dendritic cells.
Other drug therapy
Other drugs used to treat LCH include the following:
Stem cell transplant
Stem cell transplant is a method of giving chemotherapy and replacing blood-forming cells destroyed by the LCH treatment. Stem cells (immature blood cells) are removed from the blood or bone marrow of the patient or a donor and are frozen and stored. After the chemotherapy is completed, the stored stem cells are thawed and given back to the patient through an infusion. These reinfused stem cells grow into (and restore) the body's blood cells.
New types of treatment are being tested in clinical trials.
Information about clinical trials is available from the NCI Web site.
Patients may want to think about taking part in a clinical trial.
For some patients, taking part in a clinical trial may be the best treatment choice. Clinical trials are part of the medical research process. Clinical trials are done to find out if new treatments are safe and effective or better than the standard treatment.
Many of today's standard treatments for disease are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.
Patients who take part in clinical trials also help improve the way diseases will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.
Patients can enter clinical trials before, during, or after starting their treatment.
Some clinical trials only include patients who have not yet received treatment. Other trials test treatments for patients whose disease has not gotten better. There are also clinical trials that test new ways to stop a disease from recurring (coming back) or reduce the side effects of treatment.
Clinical trials are taking place in many parts of the country. See the Treatment Options for Childhood LCH and the Treatment Options for Adult LCH sections for links to current treatment clinical trials. These have been retrieved from NCI's clinical trials database.
When treatment of LCH stops, new lesions may appear or old lesions may come back.
Many patients with LCH get better with treatment. However, when treatment stops, new lesions may appear or old lesions may come back. This is called reactivation (recurrence) and may occur within one year after stopping treatment. Patients with multisystem disease are more likely to have a reactivation. More common sites of reactivation are bone, ears, or skin, and diabetes insipidus also may develop. Less common sites of reactivation include lymph nodes, bone marrow, spleen, liver, or lung. Some patients may have more than one reactivation over a number of years.
Follow-up tests may be needed.
Some of the tests that were done to diagnose the disease may be repeated. This is to see how well the treatment is working and if there are any new lesions. These tests may include:
Other tests that may be needed include:
Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.
Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your condition has changed or if the disease has recurred (come back). These tests are sometimes called follow-up tests or check-ups.
Treatment of Low-Risk Disease
Skin Lesions
Treatment of childhood Langerhans cell histiocytosis (LCH) skin lesions may include the following:
Bone Lesions and Other Low-Risk Organ Lesions
Treatment of childhood LCH bone lesions in the front, sides, or back of the skull, or in any other single bone may include the following:
Treatment of childhood LCH lesions in bones around the ears or eyes may lower the risk of diabetes insipidus and other long-term problems. Treatment may include:
Treatment of spine or hip bone lesions that have weakened the bone and may lead to a broken bone in childhood LCH may include:
Treatment of two or more bone lesions may include:
Treatment of combinations of childhood LCH skin, lymph node, pituitary gland, and bone lesions may include:
Treatment of High-Risk Disease
Treatment of childhood LCH multisystem disease lesions in the spleen, liver, or bone marrow (with or without skin, bone, lymph node, lung, or pituitary gland lesions) may include:
Treatment of childhood LCH central nervous system lesions may include various combinations of the following:
Treatment Options for Recurrent, Refractory, and Progressive Childhood LCH
Recurrent LCH is disease that cannot be detected for some time after treatment and then comes back. Treatment of recurrent childhood LCH in the skin, bone, lymph nodes, gastrointestinal tract, pituitary gland, or central nervous system (low-risk organs) may include:
Refractory LCH is disease that does not get better with treatment. Treatment of refractory childhood LCH in high-risk organs and in multisystem low-risk organs may include high-dose chemotherapy. Treatment of childhood LCH in multisystem high-risk organs that did not respond to chemotherapy may include stem cell transplant.
Progressive LCH is disease that continues to grow during treatment. Treatment of progressive childhood LCH in patients with multisystem disease may include anticancer drugs that have not been given to the patient before.
Langerhans cell histiocytosis (LCH) in adults is a lot like LCH in children and can form in the same organs and systems as it does in children. These include the endocrine and central nervous systems, liver, spleen, bone marrow, and gastrointestinal tract. In adults, LCH is most commonly found in the lung as single-system disease. LCH in the lung occurs more often in young adults who smoke. Adult LCH is also commonly found in bone or skin.
As in children, the signs and symptoms of LCH depend on where it is found in the body. See the General Information section for the signs and symptoms of LCH.
Tests that examine the organs and body systems where LCH may occur are used to detect (find) and diagnose LCH. See the General information section for tests and procedures used to diagnose LCH.
In adults, there is not a lot of information about what treatment works best. Sometimes, information comes only from reports of the diagnosis, treatment, and follow-up of one adult or a small group of adults who were given the same type of treatment.
Treatment Options for LCH of the Lung
Treatment for LCH of the lung in adults may include:
Sometimes LCH of the lung will go away or not get worse even if it's not treated.
Treatment Options for LCH of the Bone
Treatment for LCH that affects only the bone in adults may include:
Treatment Options for LCH of the Skin
Treatment for LCH that affects only the skin in adults may include:
Treatment for LCH that affects the skin and other body systems may include:
Treatment Options for Single-System and Multisystem LCH
Treatment of single-system and multisystem disease in adults may include:
For more information about LCH trials for adults, see the Histiocyte Society website.
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with adult Langerhans cell histiocytosis. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Changes were made to this summary to match those made to the health professional version.
Call 1-800-4-CANCER
For more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 8:00 a.m. to 8:00 p.m., Eastern Time. A trained Cancer Information Specialist is available to answer your questions.
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They sent one to their newsletter subscribers some years ago - I think it was before Chris took over the press. It keeps getting reactivated through all the website changes, so I assume they intend for people to be able to use it.
I have a permanent 20% off code from joining their book club a few years back. Club ended long along but code never stopped working.
The majority of the time, the only reason I buy a special edition book direct from a publisher is to keep a numbered/lettered set together. A lot of books just never sell out (or don't until deep discounts are offered), and even for the ones that do, the vast majority of those simply do not hold their value on the secondary market.
I want to be able to support publishers, but between rapid-fire releases from individual publishers, the number of publishers producing books I want, and the slow but steady rise in cost, something has to give, and it's usually my ability to buy a whole bunch of new books direct from their publishers.
I remember the permanent code as well and I had received one myself. I probably have it filed away somewhere in my email, but I don't believe I ever used it once. I'm surprised they haven't deactivated the codes since the advent of their collector's club through Patreon.
Ultimately, I like supporting the publishers directly. It's a small marketplace and these companies aren't making a fortune from the books. If I pay a little more occasionally, I'm okay with that. Especially considering the customer service from CD or Thunderstorm is so far beyond what you get from Ebay and the like.
All that being, this still has not diminished my desire to get my hands on one. If anybody is keeping track: there are only 3 lettered editions left and I still haven't received my gift certificate yet...
Except that both (or maybe it's just CD) have promoted the book in their email newsletters, touting the book as for sale through them and to, ahem, hurry before supply runs out. So CD's (and Sub's?) customers have been made aware of it and word has been spread...in fact, the title is even up on the Other Publishers pre-order page at CD:Like Dan said previously, DRP is a smaller small press and maybe the word of mouth hasn't spread like it would with a CD or a Sub Press.
That one doesn't surprise me, either, though not because of price...it already had a S/L HC edition published earlier by Overlook Connection Press just, what, a decade or less earlier? Multiple S/L HC variants and all these Anniversary Editions may work for Stephen King (and perhaps Joe Hill, and even that is questionable, given the remaining stock of 20th CENTURY GHOSTS at PS Pub.), but for everyone else there is a finite demand, as evidenced by this DR Ketchum release and several of the Anniversary Editions from other publishers that from all appearances seem to be sales-challenged. I love Ketchum, but had no interest in a S/L HC of a title of which I already had a S/L HC. Completists are few and far between...again, only King has enough of those to justify multiple collectible editions of the same title...and even that balloon's probably going to burst someday as each new release from him seems to come out with an exponential number of variants (e.g. GWENDY'S BUTTON) and collectors tire of the chase.They also have roughly 160 copies left of Off Season left as well and that's been available for preorder since October 2016. I would expect that to have sold quite a bit better as well considering the standing of Jack Ketchum and the book's place in horror literature. So obviously, what do I know?
Okay, that concludes my cynical rant of the day.
Also about Gwendy, there really aren't any more variants for that than there are for basically any other King book. There a mass market THC and TPB, we have a Signed Limited and a Signed Lettered, SST is doing a Gift Editions, then there just the standard international releases of trade editions. It just seems like there are a lot of different releases because we're doing the Limited and Lettered and someone else is doing the Gift Edition, instead of one publisher doing all three versions.
CD Email: email@example.com
Non-Work related social media and what not:
Buy my stuff! - https://www.etsy.com/shop/HockersWoodWorks
Dan, is there a UK edition other than the SST copy?
I know I've seen the covers for several European editions as well. Specifically the Greek and Polish editions.
CD Email: email@example.com
Non-Work related social media and what not:
Buy my stuff! - https://www.etsy.com/shop/HockersWoodWorks
Reality is a nice place to visit, but you wouldnt want to live there.
-John Barth
When it comes to pricing, perception about what is reasonable comes into play. Most people would balk at a $50 price tag for a book. I've had people be flabbergasted at the price of some of my books, like the $250 price tag for Summer of Night. Don't even ask me what my wife first said when I told her about the five hundred dollars I spent on the Ultra Deluxe Midnight Meat Train and that was a smoking price for that book. I think that I get used to seeing some crazy prices (Stephen King lettered editions, anyone?) and that can skew things a bit. I'm used to dropping $80 for a Thunderstorm book so the price tag for Bird Box didn't phase me in and of itself.
Great conversation, guys. I love hearing the different points of views and discussing the varying aspects of our hobby in a constructive manner!
Okay, so it wasn't that dramatic, but I was doubting things would break my way.
I had the money saved up to be able to get both the lettered editions of Off Season and Bird Box, but then stumbled upon the Kickstarter perk of the Midnight Meat Train for $500 plus matching gift certificate. While that edition of the book had never really been on my radar due to the price tag, I saw this as a once-in-a-lifetime opportunity and jumped on it, hoping that the lettered editions of the other two books would hold out long enough for the gift certificates to be dispersed. Luckily, the gift certificate came in the nick of time and I was able to snatch up both lettered editions.
In short, I was able to pick up the Ultra Deluxe Midnight Meat Train, and lettered editions of both Off Season and Bird Box for $550 plus shipping! Probably one of the best deals I've been able to swing ever!


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James Harden overshadows Jeremy Lin in Rockets debut vs. Pistons
Jeremy Lin, there's an even newer sheriff in town.
James Harden scored 37 points and added a career-high 12 assists in his Houston Rockets debut alongside Lin, giving Detroit Pistons defenders fits in his eighth career start. Harden, traded from the Oklahoma City Thunder last week, signed a five-year, $80 million contract extension Wednesday, then made good on his superstar-sized deal the same day.
The Rockets beat the Pistons 105-96 in both teams' season openers.
MORE:Harden's big contract extension
BOX SCORE:Houston Rockets 105, Detroit Pistons 96
Lin added 12 points, eight assists, four steals and four rebounds in his first regular-season action for the Rockets. But this was all about Harden.
"I think I just wanted to get out there and play," Harden said. "All the talking and all the craziness that has been happening this last week — I just wanted to go out there and play basketball."
WEIRD:Fog machine disrupts Pistons-Rockets game
Houston is gambling Harden, the reigning sixth man of the year, has starter-level talent. He does. Harden played 44 minutes and added four steals and six rebounds to his 14-for-25 shooting night. The offense flowed through him, with Lin serving as a very viable second option.
That's a superstar performance. From a giving superstar.
Harden scored 31 points in the first three quarters but spent the fourth, when Houston stormed back and pulled away, passing. Carlos Delfino, who joined Harden, Lin and Chandler Parsons in playing the final 12 minutes, scored 12 points on 4-for-5 shooting in the final stanza. Harden had five assists as the Rockets held a 33-15 edge in the quarter.
"I just tried to score and create opportunities," Harden said. "Carlos Delfino came in hot. I just tried to get my bigs involved. A lot of different guys stepped up, and I think that's how it's going to be throughout this entire season."
The other big Rockets addition of the offseason, former Chicago Bulls center Omer Asik, contributed 12 points, nine rebounds and two blocks. He was 5-for-6 from the field, but he didn't need to shoot much more.
Contributing: The Associated Press


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- Current Topics for Public Discussion
- Emergency Notification System
- Enforcement
- Information for Citizens
- Public Records Requests
- Social Media
- Contact Pullman PD
- Online Services
- News & Statistics
- About Pullman PD
- Frequently Asked Questions
- Department Services
- Crime Prevention
- Lost & Found
- Crime Mapping
Pullman Police to start targeted patrols to enforce cell phone and texting laws
Last Updated on Tuesday, 10 September 2013 09:14
For Immediate Release
June 8, 2011
Cmdr. Chris Tennant
(509) 334-0802
Pullman Police to start targeted patrols to enforce cell phone and texting laws
Pullman – Friday June 10th marks the one year anniversary of the state's updated cell phone and texting laws, which shifted the use of handheld phones or texting to a primary offense. The Pullman Police Department will increase traffic patrols targeting the illegal use of cell phones and text messaging while driving.
State law (RCW 46.61.668) prohibits "texting" while driving which is defined as a person who, "by means of an electronic wireless communications device, sends, reads, or writes a text message."
State law (RCW 46.61.667) prohibits a person operating a motor vehicle from holding a wireless communications device to his or her ear. Operating a cell phone in "Hands-free mode" is legal. Hands-free mode includes the use of a speaker phone, headset or earpiece. It is legal to use a wireless communications device to report illegal activity, summon medical or other emergency help, or prevent injury to a person or property.
The cell phone and texting laws are both primary offenses, which means an officer can pull you over for an observed violation. The penalty for a violation is $124.
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Lifelong Learning Institutes offer non-credit, college-level educational experiences, but with little or no homework and at a fraction of the cost. Classes are taught by members, retired and active faculty, and outside experts. But perhaps best of all — the life experience of all members elevates the intellectual discourse.
We work closely with the administrators and members of the more than 400 LLIs in our network to develop and share educational resources that help fulfill our shared educational missions. Road Scholar's network also facilitates communication and collaboration between member LLIs and helps to improve the visibility of LLIs in their communities.
Find out what local LLIs in your community have to offer. By joining an LLI, you'll meet new people who also love learning, gain access to a wide range of enriching classes and benefit from taking part in lively educational discourse.
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Shopping centres are adventure worlds where the customers are supposed to feel good. Excellent service and exceptional campaigns are intended to produce a positive buying mood. Today the parking system plays a key role in this scenario and not only because virtually every visitor is also a parking space user. In particular, it's because attractive and relevant value added can be generated for customers through the medium of the car park ticket.
Accordingly, a store of special tickets held in PM ABACUS can be issued by a random generator and raffled off in a prize draw. Customer loyalty cards are a part of the "mandatory programme" in retail nowadays, and these can also be deployed practicably in the field of car parking. Reduced rates for regular customers or discounts on parking fees depending on the value of goods purchased create an incentive and intensify the feeling of being appreciated as a customer.
Since discount systems are one of the great strengths of PM ABACUS, it only stands to reason that this technology is greatly appreciated by operators. Whether the devices operate on or off-line, vouchers are issued or accounting is
done by cost centre, PM ABACUS fits flexibly into existing or planned structures. The fact that special occupancy reports can be issued for shopping centre tenants, and further charging is possible on the basis of parking area utilisation, increases the benefits for operators.
If the parking management system is also connected to a registration number
recording and parking control system via the TCP/IP interface, extensive customer service opportunities are opened up. Apart from the rapid identification of vacant spaces upon arrival, the exact location of a vehicle can also be determined at any time at electronic information terminals by entering the registration number. Without any doubt, with PM ABACUS, you are ideally prepared for the challenges of tomorrow.


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I have ordered Black Berry Curve from Basatne Electronics. They delivered me the phone after 2 days.
I am really impressed with such quick delivery and nice packaging. I have gone through the manual and started my phone for the first time. I like the phone and the functionality very much. I am glad to get the mobile at best deal from Basatne Electronics. If any body looking for latest gadgets, mobiles, electronics products have a look at Basatne Electronics online store.


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Dear Abby, Saturday, Nov. 10, 2012
DEAR ABBY: My daughter, "Renee," is 25 and is an intelligent and independent woman with a good job. She has been in a relationship with her boyfriend, "Bryan," for 6 1/2 years. They have been living together for the past two years.
Bryan is nice and has a decent job, and I like him. However, there is virtually no conversation between them about what their future together holds. Renee would like to get engaged, but she refuses to bring anything up to Bryan for fear that he will feel "pushed." She wants it to happen with no prodding. I maintain that it's perfectly acceptable to ask where he sees their relationship going.
At this point, I'd like to take Bryan aside and say that I love my daughter and would like to know what his intentions are. Is that totally inappropriate in this day and age?
I know Renee would not be happy if I approached Bryan with this. Should I just keep my mouth shut and let her handle it? -- MAMA ON A MISSION
DEAR MAMA: You are well-meaning, but this is one mission your daughter must complete for herself. Please tell her that after a relationship of six years -- and living together for two of them -- having a rational discussion with Bryan would not be "pushy." In fact, it's the intelligent thing to do. He may have commitment issues. Or he may need the "nudge."
DEAR ABBY: My niece is engaged to a really nice guy who is obviously gay and in denial because of his religion. My brother and his wife ignore it because, according to them, being gay is a "sin." This couple has been out of high school for two years. They are also both virgins, which is unusual.
I had a gathering at my home, and some gay friends attended. They noticed that he was gay and mentioned it to me. Should I just stand by and keep my mouth shut? -- UNSURE IN NEW JERSEY
DEAR UNSURE: Yes, you should. Unless you are 100 percent sure the man is, in fact, gay, you should keep your feelings to yourself. Your niece's fiance may be an effeminate straight man. And your gay friends' "gaydar" may have given them a false reading at your gathering.
DEAR ABBY: I have developed a horrible crush on my kids' tennis instructor. I am very happily married and would never, ever cheat on my husband, but this man makes my heart race.
By the way, I'm pretty sure my feelings are reciprocated. What to do? -- CRUSHING MOM
DEAR CRUSHING MOM: It's not a question of what you should do, but rather what you should NOT do. Do not act on your feelings, do not spend time alone with him and do not tell anyone about it. Enjoy feeling like you are 16, and take your kids home after their lesson. In time, the feeling will fade.
Dear Abby is written by Abigail Van Buren, also known as Jeanne Phillips, and was founded by her mother, Pauline Phillips. Write Dear Abby at www.DearAbby.com or P.O. Box 69440, Los Angeles, CA 90069.


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DEA Accused Of Leaking Misleading Info Falsely Implying That It Can't Read Apple iMessages
from the that's-not-the-truth deptSo this is interesting. Yesterday, CNET had a story revealing a "leaked" Drug Enforcement Agency (DEA) memo suggesting that messages sent via Apple's own iMessage system were untappable and were "frustrating" law enforcement. Here's a snippet from that article:
Encryption used in Apple's iMessage chat service has stymied attempts by federal drug enforcement agents to eavesdrop on suspects' conversations, an internal government document reveals.CNET posted an image of the letter:
An internal Drug Enforcement Administration document seen by CNET discusses a February 2013 criminal investigation and warns that because of the use of encryption, "it is impossible to intercept iMessages between two Apple devices" even with a court order approved by a federal judge.
That leads Sanchez to wonder if there might be some sort of ulterior motive behind the "leaking" of this document, done in a way to falsely imply that iMessages are actually impervious to government snooping. He comes up with two plausible theories: (1) that this is part of the feds' longstanding effort to convince lawmakers to make it mandatory that all communications systems have backdoors for wiretapping and (2) that it's an attempt to convince criminals that iMessages are safe, so they start using them falsely believing their messages are protected.
Which brings us to the question of why, exactly, this sensitive law enforcement document leaked to a news outlet in the first place. It would be very strange, after all, for a cop to deliberately pass along information that could help drug dealers shield their communications from police. One reason might be to create support for the Justice Department's longstanding campaign for legislation to require Internet providers to create backdoors ensuring police can read encrypted communications—even though in this case, the backdoor would appear to already exist.While both scenarios are plausible, both seem fairly cynical as well. I'd like to think that law enforcement is above attempting such tricks, but unfortunately that might just be naive these days.
The CNET article itself discusses this so-called "Going Dark" initiative. But another possible motive is to spread the very false impression that the article creates: That iMessages are somehow more difficult, if not impossible, for law enforcement to intercept. Criminals might then switch to using the iMessage service, which is no more immune to interception in reality, and actually provides police with far more useful data than traditional text messages can. If that's what happened here, you have to admire the leaker's ingenuity—but I'm inclined to think people are entitled to accurate information about the real level of security their communication enjoy.
Filed Under: dea, encryption, imessages, privacy
Companies: apple


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Over the last few years, Henry County Hospital in Indiana, which services patients from a four-county region, was experiencing a growing need for expanded wound care services because of the diabetes epidemic as well as the aging population. In 2011, the hospital responded to this need by relocating and expanding its Advanced Wound Center. Providing patients care for difficult wounds that are not healing and offering hyperbaric oxygen therapy, the new state-of-the-art center features extended hours and an expanded level of treatment.
When planning this renovation, Hospital Electrician Paul Wallace says lighting was a key consideration. According to Wallace, three primary objectives were established when specifying the ambient and hyperbaric chamber lighting in the new Advanced Wound Center. First, the facility needed to find another light source besides fluorescents for the hyperbaric chamber. Second, it needed lighting that was dimmable to ensure patients remain comfortable while receiving therapy in the hyperbaric chamber. Third, decreasing energy use, reducing maintenance, and being more environmentally conscious were top concerns.
Other factors were also considered in the lighting selection process. "There are health risks associated with fluorescent lighting in hyperbaric chambers," says Stephanie Taylor, director of the Advanced Wound Center. "For some patients, fluorescent lighting can cause seizures, making it necessary for us to find an alternative."
In addition, because patients spend about 2 hours per day in the hyperbaric chamber — sometimes receiving treatment for up to 60 days — having dimmable lighting as a convenience for patients wanting to sleep or watch television was essential, notes Taylor.
Because LEDs respond well to dimming and offer tremendous energy efficiencies, the hospital began researching options for a digital lighting system. However, this wasn't the first time it had looked into LEDs. "We researched LED lighting about three years ago, but we didn't find any fixtures that met our needs," explains Wallace. "This was mostly because the color of the LEDs was harsh, and we didn't like the look of the fixtures. However, the technology and fixture aesthetics have advanced immensely over the past few years."
Steve Vorhees from Kirby Risk Electrical Supply, Muncie, Inc., and John Edwards from LightSOURCE, Indianapolis, presented Henry County Hospital with an LED lighting solution from Lithonia Lighting, an Acuity Brands company, that met all of its goals. "The VTLED by Lithonia delivers high quality volumetric lighting and full-range dimming (0V to 10V) as standard features," explains Edwards. "Additionally, it provides a plug-and-play dimming functionality that allows end-users to easily connect fixtures together, reducing installation time and expenses."
The hospital installed VTLED fixtures throughout the Advanced Wound Center, including exam rooms, dressing rooms, nurse station, and the hyperbaric oxygen suite. Sensor Switch controls were installed in the hyperbaric chamber. In addition to the product's dimmability, Wallace likes the fact that the fixtures looked similar to the facility's current fixtures, ensuring there wasn't a dramatic difference aesthetically. Another benefit, says Wallace, is the reduced maintenance required because LED lighting and controls last longer and require less service. "This allows our facility staff to focus on more important aspects of running the hospital," says Wallace.
The new lighting and controls were also well received by the Advanced Wound Center staff and patients. "The LED lighting and controls have worked extremely well in our department because it gives us more control of the lighting intensity," says Taylor. "The hyperbaric chamber suite has the lighting split into two sections — one for each chamber. The lighting system allows us to dim the lights on one side and leave them up on the other side according to the patient's preference. This gives us a lot of control and flexibility."


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We may get to find out who would win in the titanic battle between Adam and Jamie and the legendary Vegas magicians. The two pairs of geek icons are launching a serious rivalry now that they're back-to-back on Wednesday evenings, judging from this exclusive new promo that Discovery sent us. So who's got your bet?
Mythbusters returns to Discovery this Wednesday at 9 PM, with Penn and Teller Tell A Lie starting Wednesday, Oct. 5 at 10 PM.


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12th SOMATOM World Summit 2015
A special year, a special summit: 40 years after Siemens' first computer tomograph, the Siretom, went into serial production in 1975, more than 300 dual source users from all over the world convened in Munich, Germany, for the 12th SOMATOM World Summit in the summer of 2015. It was an ideal opportunity to look back to a time in CT when a whole-body examination was a vision of the future, cardiac imaging was unimaginable, and when dose values below one millisievert were little more than a fantasy. And it provided time to discuss current issues as well as future trends and possibilities in computed tomography.
4 decades of CT
Watch the scientific lectures reflecting 4 decades of CT
Walter Märzendorfer, Siemens Healthcare / Prof. Maximilian Reiser, MD, Ludwig-Maximilians-University Munich, Campus Grosshadern, Departement of Clinical Radiology, Munich, Germany
40 years of CT
Prof. Willi Kalender, MD, Institute of Medical Physics, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
Why we went the Dual Source way
Thomas Flohr, PhD, Siemens Healthcare
40 years of CT – the clinical perspective
Prof. Maximilian Reiser, MD, Ludwig-Maximilians-University Munich, Campus Grosshadern, Departement of Clinical Radiology, Munich, Germany
Low kV and Right Dose imaging
Watch the scientific lectures reflecting Low kV and Right Dose imaging
The clinical, operational and financial impacts of low kV scanning
Harold Litt, MD, PhD, Perelman School of Medicine of the University of Pennsylvania, USA
The use of low kV in thoracic imaging
Martine Rémy-Jardin, MD, PhD, Calmette Hospital University Centre Lille, Lille, France
The effect of CARE kV on radiation dose - results of a multicenter evaluation
Felix Meinel, MD, University Hospital Munich, Campus Grosshadern, Munich, Germany
Dual Energy
Watch the scientific lectures reflecting Dual Energy
Genitourinary application of Dual Energy-CT
Prof. Wang Xiao Ying, MD, Peking University First Hospital, China
The Clinical Role of Monoenergetic Imaging in Abdominal CT
Carlo N. De Cecco, MD, PhD, Medical University of South Carolina, Charleston, USA
Clinical results with TwinBeam CT in abdominal imaging
Sebastian Schindera, MD, University Hospital Basel, Basel, Switzerland
Dual Energy – the untapped potential
Anders Persson, MD, PhD, Linköping University, Linköping, Sweden
Concepts of Dual Energy imaging
Bernhard Schmidt, PhD, Siemens Healthcare, Forchheim, Germany
Watch the scientific lectures reflecting therapy
Improved CT-skeletal diagnosis in oncological patients using innovative post-processing tools
Prof. Marius Horger, MD, Eberhard-Karls-University Tübingen, Germany
Imaged-guided Neurosurgery
David Roberts, MD, Geisel School of Medicine at Dartmouth, Dartmouth, USA
Next 4 decades of CT
Watch the scientific lectures reflecting the next 4 decades of CT
Personalized CT – transforming imaging into decision making
Stefan O. Schoenberg, MD, PhD, University Medical Centre Mannheim, Mannheim, Germany
Quo Vadis CT?
Thomas Flohr, PhD, Siemens Healthcare, Forchheim, Germany
Watch the scientific lectures reflecting cardiology
The challenging cardiac CT patient
Joseph Schoepf, MD, Medical University of South Carolina, South Carolina, USA
Stents and plaques in coronary CTA – where do we stand?
Koen Niemann, MD, PhD, Erasmus Medical Center, Rotterdam, the Netherlands
Enhancing morphology by function: Dynamic MPI, the Mie Experience
Kakuya Kitagawa, MD, PhD, Mie University Hospital, Mie Prefecture, Japan
Vascular imaging
Watch the scientific lectures reflecting vascular imaging
The role of CT in TAVI planning
Marco Das, MD, PhD, MBA Maastricht University Medical Center
4D vascular imaging
Thomas Henzler, MD, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany
The role of dual energy and iMAR in vascular imaging
Professor Fabian Bamberg, MD, University of Tuebingen, Tuebingen, Germany
Acute Care
Watch the scientific lectures reflecting acute care
Bone reading in the emergency room
Helmut Ringl, MD, Medical University of Vienna, Vienna, Austria
The role of CT in patients with acute chest pain
Hatem Alkadhi, MD University Hospital Zurich, Zurich, Schweiz
Imaging trauma patients in the ER
Savvas Nicolaou, MD, Vancouver General Hospital, Vancouver, Canada
Sliding Gantry - ER and routine examination rooms
Professor Ralf Bauer, MD, Goethe University, Frankfurt am Main, Germany
Watch the scientific lectures reflecting pediatrics
The role of Dual Energy in pediatrics
Marilyn Siegel, MD, Washington University School of Medicine, Washington, USA
Pediatric imaging with the SOMATOM Force
Debbie Watson, Children´s Health Queensland Hospital, Queensland, Australia
Watch the scientific lectures reflecting oncology
Lung cancer screening – the European perspective
Prof Matthijs Oudkerk, MD, CSO Center for Medical Imaging, University Medical Center Groningen, Groningen, The Netherlands
Routine use of Dual Energy in abdominal oncology
Alec J. Megibow, MD, NYU-Langone Medical Center New York, New York, USA
Current status of low dose CT lung cancer screening in the US
David P. Nadich, MD, NYU School of Medicine, Langone Medical Center, New York, USA
Watch the scientific lectures reflecting neurology
Stroke management optimizing door to needle time
Peter Schramm, MD, PhD University Lübeck, Lübeck, Germany
Role of 4D CTA
Christoph Ozdoba, MD, Bern University Hospital, Bern, Switzerland


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On A Positive Note: Nicole Rodarte, Gary Jackson become judges. Plus, awards, new jobs and a wedding
Here comes the judge(s): Congratulations to Nicole Rodarte, a partner in Casper & Rodarte, and Gary Jackson, a partner in DiManna & Jackson, on their appointment as Denver County Court judges. They'll fill vacancies created by the January, 2013, retirement of judges Aileen Ortiz-White and Andrew Armatas.
Before entering private practice, where she focuses on criminal defense, Rodarte served for several years in the state Public Defender's Office. A Denver native and graduate of John F. Kennedy High School, Rodarte serves on the PTA of Swigert International School in Stapleton.
Like Jackson, she earned her juris doctorate degree from the University of Colorado.


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Survival Island Map
Hurray! The contest winner of the Screenshot contest have been announced! Congrats to must smile and thank you everyone for participating. Have a fun time playing Minecraft! For others who lost, don't lose hope, try out our next contest coming up. For now lets look at a Minecraft map which the yogcast have been reviewing about, they made a series about it! Try checking it out.
Sounds fun right? It is fun.. I have already tried Survival island in my own Minecraft. At first, its very hard to mine and build things. But after a while u will see that its fun! The feeling of making your own house from little bits of wood into a huge thing! Well, playing survival with no goals sux right? So the developer (Ashien) gave us some awesome + hard goals to accomplish while playing this map. Me, I have completed not all of it But its fun to try out Surviving in this map. Intelligence must be used in order to survive!
Sadly it has been discontinued, but of course the map will still work with Minecraft future and current versions. You can find other cool survival maps on Minecraft DL. But for those of you that have not tried this map out yet, you must!
Survival Island Map for Minecraft 1.10.2, 1.9.4 and 1.8.9
- Survival Island maps has 3 maps all together.
1. Don't leave the island
2. play on at least normal
3. no cheating
1. Build a two story house/base with at least 20+ windows.
2. Build 10 bookcases.
3. Build an automated cactus farm.
4. Build an under ground tree farm.
5. Build an above ground animal trap.
6. Build a drowning trap around the skeleton spawner.
7. Build a cart system.
8. Build something with redstone.
9. Gather 10 unused diamonds.
10. Find the treasure left behind by the Lost Curator.Try to complete those without cheating!
How to Download and Install Survival Island Map for Minecraft 1.10.2, 1.9.4 and 1.8.9
[cliptag link="http://p.minecraftdl.verblickcoltd.netdna-cdn.com/vod/minecraftdl.verblickcoltd/hti/survival-island.mp4″]
- Download the map above the about the author.
- Open start/run/%appdata%/.minecraft/saves
- Drag the contents inside the zip file you donwloaded into .minecraft saves folder.
- Run Minecraft.
- Play!
*If you have problems you can comment*
Have a fun day surviving! 😀


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Blend of music, dance, martial arts takes hold in Mexico
MEXICO CITY — The sounds of Africa, Brazil and Arabia echoed through the tiny studio, bringing 25 students together in a circle to sing what sounded like an African-American spiritual.
Two fighters jumped into the middle of the circle, their movements so fluid and connected to the music that, at first glance, it looked like a choreographed dance. Yet the movements mimicked the martial arts in the blend of dancing, fighting, music and acrobatics that is capoeira.
"There are many dimensions to capoeira," said Adolfo Flores, a capoeira (pronounced cah-poh-AY-rah) master who teaches at a studio in Mexico City's Roma neighborhood. "A person needs to be a musician to learn capoeira; a person needs to be a dancer to practice capoeira; a person needs to be involved with martial arts, because at the very end, capoeira is martial arts."
The look and sound of the mysterious art form have become increasingly popular in Mexico in the last five years.
Every Saturday at around 4 p.m., the streets in one of Mexico City's southern neighborhoods transform into a stage for the Roda de Capoeira, the Circle of Capoeira, where the performances take place.
Jingling tambourines offset the low beat of the atabaque, a conga-like drum from Africa. Flores directs the capoeira ceremony with the berimbaus, a bow-shaped instrument with metal strings, as he glides a wooden stick across it while shaking a rattle in his other hand.
"Capoeira is exactly what you see," said Flores, who's been a teacher for the past seven years. Putting it into words is difficult, even for a capoeira master such as Flores.
Though it may look like a choreographed dance to the uninformed, it's much more than that, he said. Capoeira enables a follower to become a fighter and a singer, he said.
Its traditions are deeply rooted in African and Brazilian culture, and it has some Arabian musical influences, as well.
Its origins and even its name are widely disputed. Is it strictly a Brazilian form of dance integrated with African fighting techniques, or an African form of fighting with influences of Brazilian dance?
The most accepted explanation is that capoeira was born in the 16th century when slaves from Angola were taken to Brazil.
"In Brazil, particularly, the black people survived through capoeira," said Angel Rivero, a 25-year-old Venezuelan who moved to Mexico City to get his master's degree. "It was just a way of rebelling against the oppression, the slavery."
Capoeira became a way for the African slaves to defend themselves against their Brazilian masters. The movements within capoeira are acrobatic, mixing back flips and cartwheels with kicks and karate chops.
According to Princeton University's capoeira Web site, the dancelike appearance of capoeira was a way for Africans to disguise its practice from their Brazilian masters. Its lack of physical, direct contact and aggression was yet another way to disguise its purpose as a form of self-defense.
Although it once was banned in Brazil, capoeira has continued to grow since the 16th century, and it's become popular all over the world. It's played throughout Mexico, Australia, Brazil, Venezuela, Europe and the United States.
In Mexico City, the Roda de Capoeira is played as street fighting among teams like the one at Flores' studio.
"You know, being inside a circle of capoeira in which every single person is involved, something happens during that time that every single person is so committed to what is happening at that moment. That's wonderful," Flores said.
Capoeira's recognition in Mexico has grown over the last five years because of its portrayal in posters, magazines and TV, Flores said. It's most popular with youths ages 15 to 25, but it's practiced among people from ages 3 to 55.
"We believe there are no physical limits for capoeira. I truly believe that anybody can learn it," he said. "I have a person that weighs over 120 kilos" — 264 pounds — "and also I have seen people with Down's syndrome who practice capoeira. There was one guy who was armless, a couple of deaf people."
It's not limited to men, either, said 33-year-old Nora Flores, who's been practicing for a few years and who's no relation to Adolfo Flores.
"You know, women have to look for a place in whatever they like to do," she said. "Though the number of men is (larger) than the women, women are involved in the same way men are involved in capoeira."
The master and the students said that capoeira tested and strengthened them physically and mentally. The changes and challenges that each player faces are different, and the experience of capoeira is unique to each person.
"First of all, capoeira is life," Rivero said of his own experience. "Second, it is energy, it is humble, it is friendship and it is strength."
(Petri graduated this month from Penn State University. This story was reported from Mexico City for a class in international journalism.)
Despite grim economic news, some foresee recession's end
Afghan drug trade thrives with help, and neglect, of officials
Are health groups' voluntary actions enough? Likely not


text: The frustration of failed IVF cycles leads many women to seek explanations and investigate alternative options. from shutterstock.com November 10, 2016 Suppressing the immune system won't improve your chances of conceiving with IVF Sarah Robertson, University of Adelaide In pregnancy, immune cells help the uterus tolerate and nurture the embryo despite it carrying foreign genes from the father. In most women, suppressing immunity will likely cause more harm than good.


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Tuesday, September 30, 2008
Jumbomania! 1993 Bowman
Next up, a Jumbo pack from a time when Bowman baseball truly was "The Home of the Rookie Card," 1993. There are 22 cards in this pack, and the "money card" is a Derek Jeter RC; which after the SP RC, is probably his "best." There's also the only true RC of Andy Pettitte.
Posted by Chris Harris at 6:45 PM
Labels: 1993, Baseball, bowman, Chris Harris, Jumbo, video pack break
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Five buildings burned in Snake River fire
Thu., Aug. 7, 2014
LEWISTON, Idaho (AP) — Five structures have been destroyed by a wildfire burning in northern Idaho and fire managers on Thursday planned a burnout operation to halt the fire's northeast expansion.
Big Cougar Fire spokesman Tom Rhodes says it's unclear if the destroyed structures are homes or outbuildings in the remote area accessible only by boat.
The fire is on the east side of the Snake River across from Oregon and Washington state.
Rhodes says about 160 structures are threatened by the 64-square-mile fire burning in mostly grass but also some timber. Residents have been told to evacuate.
No injuries have been reported.
About 319 firefighters plus four helicopters are fighting the lightning-caused blaze that started Saturday.
Rhodes says the Snake River is preventing the fire from reaching Oregon and Washington.
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Gothic Dungeon Building
You are going to see a lot of dungeon sections below.
Don't feel that you have to build them all!
Begin with a few of the
Basic Gothic
pieces. You can cast, build, paint them in a couple of days and see how well you like them. Later you can add on Detailed sections and
all of the pieces will fit together!
Basic Gothic Pieces
These are simple pieces using
only molds #45
(gothic dungeon builder mold)
and #201
(floor tile mold). They don't take much time and are easy to make. These are the best pieces to start your dungeon and you can always add detailed pieces later.
Click here to go to Basic Dungeons
Advanced Gothic Dungeon Pieces
These pieces
use a number of different molds
and are much more detailed.
The possibilities here are endless!
This section shows how to build your own custom sections to fit seamlessly with everything shown here.
Click here to go to Detailed Dungeons.
http://www.hirstarts.com. All photos, articles and plans are copyrighted by Bruce Hirst and may not be used without permission.
"Castlemolds(R)" is a trademark of Hirst Arts Fantasy Architecture Inc.
For more information contact


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What To Wear: Heated Workouts
Some like their workouts hot. Like crank up the thermostat, make it sizzle-type hot. Bikram Yoga used to be the talked-about heated workout, but now New Yorkers are demanding their favorite workouts turn up the thermostat. Within the past few months I've seen (and tested) hotties including hot barre and boot camp classes, and it terms of outfit choices, it's a whole different approach.
Since working out naked isn't exactly an option, the next best thing is fabrics that are chafe-resistant, feature strategic cooling ventilation and won't cause embarrassing sweat stains or odors. My basic advice: avoid cotton--it becomes extra heavy as it soaks up the sweat. Look for sweat-wicking fabrics that draw the sweat to the outside of the garment to evaporate and leave skin dry and cool.
"Sweat is an athlete's best friend because it helps cool them down. If a garment gets heavy and soaked full of moisture, the cooling process won't work," Udo Mueller, Head of Technical Marketing Innovation at Adidas says. (See the technology Adidas came up with as a solution below.)
Here are some heated workout-approved picks:
The name says it all. Lululemon Hot & Sweaty short ($48, lululemon.com) were created specifically for hot yoga lovers. Featuring Power Luxtreme (an extra-fast wicking fabric) the shorts have drawcords which allow you to customize your fit because the last thing you want to waste energy doing is fidgeting with your shorts during a hot yoga session. The thick, smooth waistband has chafe-resistant flat seams that feel good against the skin, even when sweat-soaked.
The shorter the shorts the better when it comes to Bikram yoga wear. NUX's Focus Boy Shorts ($36, nuxusa.com) use a 3-way sweat-wicking fabric that stays dry and feels silky against the skin. The moisture-protecting features help prevent any embarrassing sweat stains (wear black for the most visualize protection!).
Adidas' ClimaCool technology is is a combination of performance fibers, wicking fabrics and open mesh designed to keep cool air flowing while heat and sweat out. The technology is integrated into various pieces and I tested the ClimaPower tank ($40, adidas.com) during a hot yoga session. The strategically placed ventilation mesh zones (under the bust and down the back) kept hot spots feeling cool!
Not every hot workout is done barefoot. Case in point, Chaise23's Hot TRX class and running outside anytime during the months of July and August. To keep feet cool, Adidas' Climacool sneakers ($100, adidas.com) feature ClimaCool ventilation around the entire foot, a comfortable mesh lining and perforated sockline to increase the shoe's breathability and reduce heat and sweat--its design acts like a mini air conditioning unit for your feet!
When you need an instant recharge before heading back to game, Mission Athletecare's EnduraCool cooling towel will be your sideline solution ($14.99, missionathlete.com and select sporting goods stores). Developed as response to athlete's complaints of overheating, EnduraCool is a dual-use product-- when it's dry the fabric acts as an absorbent cloth and when it's wet and snapped, the chilling technology is activated, cooling the fabric to near 59 degrees in about a minute.
Sweating is healthy, but it can also make for a dangerously slippery yoga mat. Lorna Jane's non-stick Yoga & Pilates Socks feature a rib knit and non-slip coating make sure your yoga practice doesn't become a slip and slide. The socks ($14.99, lornajane.com) also feature moisture-wicking proprieties, meaning no stink!
Expert Pick: Heather Burghorn, Hot TRX class instructor at Chaise23 in New York City.
Favorite Tank: Lole Women Zenith Tank ($60, lolewomen.com)
"It is the perfect tank to keep you cool and dry during sweaty workouts. The bonus with the Zenith tank is you get all the benefits of glistening but none of the smell (they put this tank through an anti-bacterial treatment process, so it prevents odors)."
Related Links:
33 Hot New Workouts You Can Try At Home
Heat Up Your Workout With Bikini-Bod Moves
Feeling Shy? The Best Anti-Cellulite Solutions
For daily fitness tips follow SELF on Facebook and Twitter.
Get SELF on your iPad and Kindle Fire!


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This whitepaper describes the formal and informal file-sharing methods business employees use to perform their daily functions and explains that, from sending small text documents to multi-gigabyte video files, the right managed file transfer (MFT) solution can allow such transfers to continue without risking the security of the corporate network. The paper explains that the right MFT solution can enable business growth, enhance operational efficiency, enable compliance, reduce costs, and increase ROI. Choosing the right MFT solution requires eight considerations described in the paper, and concludes by explaining why Globalscape solutions are the choice of our customers around the world.
© 2019 BenefitsPro. A Summit Business Media publication. All Rights Reserved. Privacy Policy


text:
Diplomat writing instruments have been manufactured in Germany since 1922. All Diplomat pens are handcrafted and then tested in their workshops; they believe no machine can replace the guidance and expertise of a passionate craftsman. Diplomat's fountain pen nibs are custom made from Stainless Steel offering a unique sensation of control. Schmidt's EasyFlow refill is used for ballpoint pens. It offers an incomparable writing experience. This 'old world craftmanship' demonstrates Diplomat's commitment to fine writing excellence.
The legacy of the Zeppelin is preserved in this sleek writer with smooth lines. Notice the aggressive aluminum body. The Aero features a full aluminum casing and matte black trims. The orange and black finishes are anodized for durability.
The Diplomat Skyline collection makes an aggressive color statement. Crafted from aluminum and finished in a brilliant red or blue finish. These finely crafted German pens are not your typical conservative colors.
The fountain pen features a stainless steel nib. The ballpoint arrives with Schmidt's EasyFlow refill. The fountain pen and rollerball both will post the cap onto the body. Use cartridges or your included converter for bottle ink.
A² is a new generation of Excellence, in a timeless design. This evolution has been focused on the experience of use, with a new exclusive closure system realized by its softness and durability. The Excellence A² is now equipped with a spring-loaded clip, making it easier to hold the pen to a pocket or a folder.
The lacquer is hand finished. The trims are gleaming gold. The fountain pen can be selected with a stainless steel nib or the ultra-flexible 14k gold. The ballpoint features Schmidt's EasyFlow refill. The fountain pen and rollerball both will post the cap onto the body. Use cartridges or your included converter for bottle ink.
That's what we think when we see one of these casual pens. Designed for both the liquid ink writer in a stainless steel nib or the ballpoint lover which features Schmidt's amazing EasyFlow ballpoint refill.
Crafted in brilliant multi-layered lacquer combined with chrome trim. A value and style that can't be matched.
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text: This line is aptly named, with it being simple and effective. These bags are designed to be ideal companions for your daily wanderings and trips. Their canvas is as delicate as it is robust, with each model featuring many practical storage spaces. The full-grain leather detailing comes in patent or with a glitter effect, depending on your preferences. As for their colours, they move with the seasons in line with the latest trends.


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Lol: Most Well Mannered Robber Pays For His Coffee, Pulls Out A Gun & Then Asks Politely For The Cash! "Its Not Personal. Its Just Business"
Friendly Robber
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text:
I thought there was not way you could make a Sandy disaster image look even worse that what they normally are but, as it turns out, it is possible. Just add a freaking puppet to it.
Reader Josef Abramov sent this image to us today:
I walked out of my house in Rockaway (one of the areas hit the hardest) and saw this terrifying puppet laying in all this destruction... it really deserves to be seen by a lot of people.
Indeed. Thank you for the extra nightmare.
You can't really beat this. Unless... unless you put a mime crying on a corner. [Thanks Josef!]


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Welcome to the amino acid powerhouse…
The THRIVE Experience, THRIVE Plus line and THRIVEFIT line of products are all technologically advanced and unique. However, THRIVEFIT CIRCULATE should win an award for the most developed, advanced, and results-driven fitness product of the year. This advanced BCAA (branch chain amino acid) formula is the perfect pre-exercise tool, formulated to give you the quality of life you deserve, even on days you don't exercise. A precise and proprietary blend of amino acids, powered by 3000mg of one of the purest and rarest forms of L-Arginine available, our core activated formula is going to provide noticeable results.
Due to the great benefits CIRCULATEcan produce, it's not just an exercise drink or just for people who exercise. CIRCULATEcan be taken on your days on and off exercise to maintain consistent amino blood levels, and it's a great product for anyone and everyone to enjoy regardless of exercise routine or lack thereof. Take your quality of life and your exercise routine to the next level with THRIVEFIT CIRCULATE.
3000mg of Premium
Grade L-Arginine


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Artist's description:
This is a drawing on high density watercolour paper I used markers, colored pencils and gel pens. I use only top quality art materials. Finest quality high grade professional markers. The colors may look a little bit different depending on the screen. An artwork is signed on the front. Original title is written on the back. A signed Certificate Of Authenticity will be included with the artwork.
Size: A5, 21 H 14.8 W x 0.1 cm, 8.3" x 5.8" x 0.04"
This original painting is currently for sale.
Please note, painting is being sold unframed. Framed picture is only for your reference. The mounted work will fit in a A5, 21 x 14.8 cm, 8.3" x 5.8" frame.
In order to protect your painting I will pack it with great care using quality shipping packing materials designed for art safe delivery. It will be packaged in reinforced envelope with bubble support for safety. Labeled: Fragile. All artworks are shipped within 1-5 business days. Worldwide shipping takes around 10 days to arrive, depending on it's destination. Each painting is inspected and professionally packaged for safe travel so that your artwork arrives to you in perfect condition. All works are insured for the whole evaluated price.
Please feel free to contact me if you would like to ask any questions.
© Pamela Rys
Materials used:
markers on paper
La Vida Biba : 8" x 6" - 21 x 15 cm - contemporary drawing by Pamela Rys (2017)
Ink drawing by Pamela Rys
- Ink drawing on Paper
- One of a kind artwork
- Size: 5.83 x 8.27 x 0.04 in (unframed)
- Signed on the back
- Style: Urban and Pop
- Subject: Flowers and plants
This artwork is sold by Pamela Rys from United Kingdom


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This is another Teed Off Tees original graphic print t-shirt. Printed on a classic black soft American Apparel t-shirt.
Add To Cart
Welcome to Teed Off Tees
Welcome to Teed Off Tees, your one stop destination for classic, retro, vintage and vibrant graphic t-shirts. We offer comprehensive range of cool T-shirts for menand women. Choose anything from Funny slogan t-shirts to Retro graphic t-shirt/tees, we offer something for everyone. Teed Off Tees have been delivering the highest quality designer graphic t-shirts exclusively for the fashion conscious for over 11 years.
We are inspired from all walks of life. We choose the best and funniest graphics, designs and slogans from around the world and it is Printed on American Apparel just for you. Just visit our store to choose from our exciting range of tees, Fun hipster t-shirt/tees, Cool vintage tees/t-shirts, Retro graphic t-shirt/tees and tons more all at one place. The days are gone when you have settle with the boring design and stretched out tees get the best with our exciting collection. Choose from our wide range of Cool t-shirt designs for a perfect night out and our t-shirts will definitely be a conversation starter. We also have offer jewelry and accessories handmade in Bali.
Teed Off Tees is your ideal selection for all your t-shirt needs. Get the best pricing and hassle free online shopping experience always with Teed Off Tees.
email@example.com (562) 714-7022