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Red and yellow leaves adorn trees along the Big Thompson River on Wednesday, Sept. 24, 2008 that have changed colors for fall.
Sally Wabeke, left, board of directors president for the Community Kitchen, and Joseph Findley, board president for Meals on Wheels, share a laugh while holding pots and pans shortly before the official groundbreaking for the new Community Kitchen on Monday at Meals on Wheels.
Wood carver Brian Odermatt of Westminster studies a wood carving during the Northern Colorado Wood Carvers 17th annual Show, Sale and Competition on Sunday at The Ranch.
Harold Nickerson of Fort Collins darkens areas of a wood burning he did of a wagon on his grandfather's homestead near New Raymer while at the Northern Colorado Wood Carvers 17th annual Show, Sale and Competition on Sunday at The Ranch.
Steve Scott of Erie and Catherine Blichfeldt of Longmont stroll across Jefferson avenue eastward on Fourth Street Sunday after an early afternoon shower blew through the area. Today is expected to be cooler with highs reaching the upper 50s and a 50 percent chance of precipitation in the afternoon.
A Denver psychic known only as Jyoti talks with Tasha Shropshire, right, of Fort Collins on Sunday at the Fall Holistic Health Fair at The Ranch. Area fortune tellers, psychics and healers set up booths over the weekend to offer Northern Coloradans alternatives to physical and spiritual healing.
Scott Allen, back left, and Joy Jackson perform during open mic night on Thursday at the Pourhouse 124 E. Fourth St. in downtown Loveland.
Marjorie Ford, who lives at the Good Samaritan Society Estes Park Village walks in memory of her husband Thomas Ford Saturday during the 20th annual Memory Walk along the Recreation Trail.
Walkers crowd the Recreation Trail near Centennial park on Saturday during the 20th annual Memory Walk. They gathered and walked to and from Wilson Avenue to honor those who have died or suffer from Alzheimer's disease.
Kari Till, 19, right, and Adam Ellzey, 20, of Greeley walk in support of Till's grandmother Karen McKelvey who lives with Alzheimer's disease on Saturday during the 20th annual Memory Walk along the Recreation Trail.
Big Thompson Elementary third-graders separate pumpkin seeds from the "guts" Friday at the High Plains Environmental Center. From left they are Emily Soule, 9, Tessa Dawson, 7, and Anthony Pierro, 8. The students will return next spring to plant the seeds they harvested.
John Gaisthea, dressed in Hopi attire, dances for students from three Loveland schools Friday at the High Plains Environmental Center in east Loveland.
Berthoud resident Sheila Gowin, left, and Cindy Coughenour of Loveland share a laugh while having a meal at Henry's Pub, 234 E. Fourth St. on Thursday, Sept. 17, 2009 in downtown Loveland.
File photo: Two years ago, Monroe Elementary School third-graders sat in a tepee while they learned about American Indians. From left they are Ernesto Romero, Lily Trapp and Isabella Vasquez. Two tepees set up at Garfield Elementary this week were heavily damaged by vandals and had to be taken down.
To prepare for the Monday opening of the Island Grill in Loveland, general manager Lisa Archibeque, left, and Jessica Kuk, bartender, proofread the menus.
Large screws fill a bin in the foreground as Jason Kupkovits, sales manager at Therm-Tech, gives a tour of the new facility to Diana Duncan of Loveland on Thursday, Sept. 17, 2009.
Cleanup at a suspected meth lab on Jo Ann Court in southwest Loveland on Thursday, Sept. 17, 2009.
Carlin Barkeen of Berthoud walks with her sons, Gavin 4, left, and Grant, 2, Wednesday evening, Sept. 16, 2009, in Berthoud. Barkeen runs with the Berthoud Run/Walk Club, an exercise group open to anyone in the community.
Loveland firefighters Shelby Vrem, left, and Cliff Shuffler try to get the horn to stop blowing on a pickup that smashed through a fence and into a garden in the 800 block of North Madison Avenue in Loveland on Thursday, Sept. 17, 2009.
Longtime elementary school teacher Ellen Javernick of Loveland has written a number of books and articles. Her most recent published work is a story in "Chicken Soup for the Soul — Living Catholic Faith."
Lily Lake in Rocky Mountain National Park.
George McGovern, 87, retired senator and 1972 presidential candidate, talks about health care, his new book about President Abraham Lincoln and more Wednesday while speaking with members of the media in Fort Collins.
Ducks at Lily Lake in Rocky Mountain National Park.
Former Sen. George McGovern's book on Abraham Lincoln.
Workers install a box culvert on Tuesday, Sept. 15, 2009 west of Interstate 25 at the intersection of Highway 392 and the Poudre River Trail.
Boaters take advantage of the warm weather and the historic high water levels Tuesday afternoon at Carter Lake. The swim beaches and boat ramps at both Carter Lake and Horsetooth Reservoir will remain open through the end of September.
Bradyn Cronin of Loveland, 21 months, dips his toes in the Big Thompson River with some help from his mother, Kim Cronin, and his grandma, or mimi, Karen Cronin, Monday afternoon a Fairgrounds Park in Loveland.
Larimer County Sheriff Jim Alderden points Monday to an area on a map where two women were attacked by a man with a knife on Sunday. The women used a walking stick to fight back and escaped.
Charlotte Hinger sits in her Loveland home office with her newest book, "Deadly Descent."
Larimer County Sheriff Jim Alderden speaks to members of the media about two women who were attacked Sunday near the Pingree Park area in Larimer County.
A wooden bowl created by Fort Collins resident Trent Bosch on display at the 11th Annual Rocky Mountain Woodturning Symposium on Sunday, Sept. 13, 2009 at The Ranch.
Tom Steyer of Omaha, Neb. demonstrates a tool of his called the TransFormer as he carves on a block of wood during the 11th Annual Rocky Mountain Woodturning Symposium on Sunday, Sept. 13, 2009 at The Ranch.
Fort Collins resident Trent Bosch holds up a wooden bowl as he demonstrates how to make it during a class at the Eleventh Annual Rocky Mountain Woodturning Symposium on Sunday, Sept. 13, 2009 at The Ranch. For more information on upcoming workshops taught by Bosch visit http://www.trentbosch.com or call (970) 568-3299.
Raymond Cole, 17, left, and Bob Butcher lay out their cards while playing a hand of bridge on Sunday, Sept. 13, 2009 during the Northern Colorado Summer Sectional at The Ranch.
Teams compete in the Northern Colorado Summer Sectional bridge tournament on Sunday, Sept. 13, 2009 at The Ranch. Clockwise from left are Jim Allen, Irene Bock, Bill Dorin and Nancy Herdfelder. The twice-a-year tournament drew hundreds of competitors of all ages.
Boulder resident Raymond Cole, 17, contemplates his next move while playing bridge in the Northern Colorado Summer Sectional on Sunday, Sept. 13, 2009 at The Ranch.
Eleven-year-old Burke Snowden of Fort Collins plays a hand of bridge during the Northern Colorado Summer Sectional tournament on Sunday, Sept. 13, 2009 at The Ranch.
Kathy Reams, left, and Rick Roberts, both members of the Loveland Road Runners, pose for a photo dressed as vampires. The running club is trying to break a world record by gathering the largest number of people dressed as vampires in one place.
Alia Jackson, 11, left, chats with Terry Madigan during the Peace in the Park event on Saturday at Civic Center Park in Loveland.
Loveland resident Joyce Caufman holds her umbrella as she walks past Ben Baca, 12, front, Maria Chacon, 17, and Danny Zaiger, 19, as they draw with sidewalk chalk at Civic Center Park during Peace in the Park.
Colorado State University football fans Sam Hoffecker, 11, left, of Fort Collins and Cameron Naseman, 10, of Highlands Ranch cheer on the Rams as they take on the Wildcats of Weber State on Saturday, Sept. 12, 2009 at Hughes Stadium in Fort Collins. The Rams won, 24-23, and have an undefeated record of 2-0 on the season.
Loveland resident Brandon Soule stands in his driveway as he talks about his 1969 GMC half-ton pickup that he has owned since 1995.
An American flag flying in the wind frames flags flying at half-staff Friday morning at Resthaven Memory Gardens north of Loveland. Staffers at the cemetery raised flags throughout the grounds to commemorate the anniversary of the Sept. 11, 2001, attacks and to honor and salute American heroes.
Five-year-old Jonah Speyer of Westminster sports a sailor hat as he prepares to wave goodbye to his great-grandpa, John May, who headed off Friday morning from the Embassy Suites in Loveland to catch an Honor Flight to Washington, D.C., with other local veterans. May served in the Navy during World War II and was part of a group being taken to the capital to visit the World War II Memorial and other sites.
Chip Jansma, owner of Loveland Auto Salvage, takes inventory information Thursday from a row of vehicles on his lot that were part of the Cash for Clunkers program.
Orange rays from the setting sun stream between mountain peaks and over the old sugar factory on Friday, Sept. 12, 2009, in this view from east Loveland.


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Bobby Roode Interview – Losing World Title Match Last Year, Hogan's Critical Remarks
July 4, 2012 · 0 Comments
This past Sunday night TNA Champion Bobby Roode stopped by The LAW to promote this Sunday's 'Destination X' (presented by Viewer's Choice in Canada) pay-per-view he headlines against Austin Aries. The full interview is available at FightNetwork.com and also on iTunes (subscribe to 'Live Audio Wrestling'). Here are a few excerpts from the interview:
On his first singles run after Team Canada broke up: "In hindsight, I honestly thought that when I broke off from Team Canada, I was gonna get that push. I was starting to be elevated slowly; I obviously had that match with Jeff Jarrett, I had a run with Booker T, and I was right on the brink. That extra push, I think, would have put me through the top, and I think for whatever reason it didn't happen. Now, when I got the opportunity to step away from Beer Money, I kinda remembered that, and I wanted to really make the best of the opportunity that I had as a singles competitor, and really stand out. Whether I had two minutes on TV or twenty minutes on TV, I wanted to be remembered. I wanted that segment to be remembered; I wanted to be the best thing on the television show; I wanted to entertain people, and really show what I had to prove. I think I've done that, and obviously being a world champion has shown that I'm able to be a top guy outside of a tag team. It's been a learning experience, the whole thing has been a learning experience, and I continue to learn even now. It's been different, definitely a different run than the first time."
The events during the day of 'Bound for Glory' last year: "It was interesting to say the least, but the only thing I can say is that obviously things happen for a reason. Looking back, if I had defeated Kurt Angle that night and went on as a world champion as the babyface, who knows how long I would have lasted? I think just the character change, and turning into the "It Factor" and the "Leader of the Selfish Generation" gave me that little bit extra, and obviously has done well for me. It's not only helped elevate myself, but it's elevated other people. It's elevated James Storm as well. Like I said, everything happens for a reason. People were obviously disappointed. I was really disappointed, but a short time after that, it was November the 3rd, I ended up winning the world title."
Hulk Hogan's assessment of Roode at the time: "Like I said, things happen for a reason, and things are said for a reason. It's professional wrestling, and everybody's entitled to their own opinion. I just took it as an eye-opener, and it did put a chip on my shoulder. When I went out there that night and I lost to Kurt, that pissed me off. Hulk's comments, and losing that night on such a big night, after such a big build-up, getting the opportunity again on television to go out there and possibly be a world champion changed my focus and changed my attitude."
Transcribed by Chris Maffei
Source: LordsofPain
By Adam
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subset: commoncrawl


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RICHMOND, Va. - VCU Head Women's Basketball Coach Marlene Stollings has named 21-year coaching veteran Niki Dawkins as the Rams' top assistant coach and recruiting coordinator.
Prior to joining VCU, Dawkins spent seven seasons as an assistant coach and recruiting coordinator at Old Dominion University under legendary head coach Wendy Larry. Combined, Dawkins helped the Lady Monarchs to a 158-67 overall mark, four Colonial Athletic Association Tournament titles, which was part of an unprecedented 17 overall league championships, and four NCAA Tournament appearances, including a run to the Sweet 16 in 2008. Old Dominion remained the dominating force in the CAA during her tenure as Dawkins helped the Lady Monarchs post an astounding 105-21 record in league play.
"It is such a privilege to have someone as decorated as Coach Niki Dawkins joining our staff," said Stollings. "Her coaching accomplishments coupled with her playing accolades will provide our program with invaluable insight. Coach Nik is an experienced and relentless recruiter with an exceptional ability to interact with student-athletes. She will have an immediate impact on our ability to attract top talent to VCU. I am thrilled she is joining our Ram family."
During her career as both a head coach and an assistant, Dawkins has participated in five NCAA Tournaments, including a trip to the Sweet 16, and five league championships (four CAA and one Horizon League). She has also coached five WNBA players, 15 All-CAA honorees, five CAA All-Defensive Team selections, three All-Horizon recipients, four Tournament MVPs, eight All-Academic honorees and four Dean's List recipients, while also signing several top rated recruiting classes. In 2005, Dawkins was named one of the best Head Coach/Assistant Coach combinations in the country.
"It gives me great pleasure to work with one of the brightest young minds in the game today," added Dawkins. "Coach Stollings has proven at Winthrop that she is extremely talented, but more importantly a winner. She has just scratched the surface on the impact she will make on women's basketball in the future. I am extremely excited about being a part of her staff and a tremendous university in VCU."
As a player at The Ohio State University, Dawkins garnered All-Big Ten First Team honors, Chicago Tribune Player of the Year accolades and Scarlet & Gray Player of the Year status. She is also a member the Big Ten All-Decade Second Team, the Ohio State University All-Century squad, and the school's Athletic Hall of Fame. From 1985-89, Dawkins helped the Buckeyes to three Big Ten Championships and four NCAA Tournament appearances (two Sweet 16 and two Elite Eight finishes), while receiving First Team All-America honors from both Kodak and Street & Smith. She is also the recipient of four gold medals (three as a player and one as a coach), a silver medal, and was named one of the most influential African American athletes to ever play at The Ohio State University.
Dawkins has extensive coaching and playing experience, including head coaching stints at New Mexico State and Detroit Mercy, as well as assistant coaching positions at Texas Tech, New Mexico State, Ohio State, and Michigan.
Internationally, Dawkins has been active with USA Basketball both as a coach and a player. In 2002, she was an assistant with the U.S. 20-and-Under squad that won the gold medal at the COPABA Young Women's World Championships in Ribeirao Preto, Brazil. During her collegiate days, Dawkins was a member of two USA Select Teams (1988 & 1990), the World University Team (1989), and the Junior National Team (1987).
Dawkins and her husband, Tony, a men's college, NBDL and WNBA official, gave birth to twin girl and boy babies, Amani and Isiah, on Sept. 14, 2011.


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Africa is often glossed over as an insignificant contributor when it comes to tech innovation and yet, it is one of the greatest. We all know of Elon Musk and his futuristic visions, but how about the lessor known Jamila Abass – a 30 year old woman from Nairobi who invented an SMS aggregator platform for subsistence farmers who require best-practice farming knowledge as well as product news and sources; or the simple M-Pesa, an effective mobile based money transfer system. Innovated in Kenya with the drive to find a way to enable rural communities to pay vendors without cash, the system runs on a rudimentary cell-phone with endless battery life and no complicated clutter. Africa is an innovator, but the caution with which business embraces new technology is still prohibitive.
Early adoption comes with pitfalls, the main being cost and failure. The conundrum is the balancing of these risks with the prospective catapulting effect early adoption can offer. Competitive advantage is the key to survival in an increasingly challenging market. With the recent exit of the United Kingdom from the European Union, investors have withdrawn their capital and redirected it into bankable commodities and stable markets. The piece of pie is smaller and the need to grab the crumbs is higher than ever. So at what point does early adoption become critical to survival as opposed to an enabler to failure?
The biggest hurdle seems to be perceived prohibitive costs, and when faced with un-tested costs, the C-suite is playing a conservative game. Adopting new technology before your competition can be an unnecessary gamble. It can hurt the business sufficiently to end it. Furthermore, Africa, whilst an innovator, is not at the forefront of widespread tech accessibility and the baby boomers of the boardroom would rather wait than lead, resulting in a subdued take-up. After all, not everyone is a Microsoft, Google or Tesla. Technology and early adoption is less imperative to each sector.
That being said, as tiresome as it gets, the taxi industry was certainly not reliant on technology. As recently as a couple of years ago, radio dispatch was the primary form of communication between the call-centre, the taxi driver and the customer. Uber removed the entire call-centre. In fact, they removed the taxi as a cost to company. Whilst an extreme story of industry disruption, those left behind, have been left behind for good.
But isn't it better to allow the creases to be ironed out first, you may be asking, and certainly, this is a valid and rational approach. Even the great tech giants, Apple, are allowing their competitors to test the waters and fix the problems with virtual reality. That being said, Apple has a loyal customer base that will wait alongside their brand. On the flipside is the caution of camera company Nikon. Canon introduced video to their DSLRs in 2008 which saw many purists dismiss the innovation. Nikon concurred with the purists and waited. In this cutthroat sector, they quickly lost market share to Canon and were forced to scramble into the segment, spending numerous years on the video back foot, slowly regaining their customers.
Financial benefits aside, perhaps the biggest benefit of early adoption is that of talent. The current workforce of the future is still in school. They're tapping away on their cell phones, snapchatting, tweeting and tumblring away. Their world is vastly different from the leader of today's traditional business, and certainly, a company pioneering their industry will be seen as the employee of choice to these emerging minds. If early adoption is ignored whilst the competition plunges ahead absorbing those risks, talent acquisition may just become the greatest obstacle for those left behind. So one has to propose, although Africa is still technologically immature (despite our rich culture of innovation) is our conservative approach to technology laying the groundwork for future failure in securing our most precious resource, human capital? In light of this, it is time to investigate the financial pitfalls of early adoption more closely. Perhaps the risk is less severe than anticipated, particularly if we consider the loss of choice employees.


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This gorgeous wavy swept-to-the-side hairstyle is a staple on the red carpet and the perfect go-to do' for any holiday party. Slight changes can make the style lean towards classic or read more edgy (the difference is in what you do to the slick side). If clean and simple is what you're going for, follow Amanda Seyfried's lead and pull one side of your hair back and secure with bobby pins, sweeping the rest of your hair over your shoulder. For something a little more daring, copy Scarlett Johansson's faux-undercut and French braid a few strands from the ear to the crown in a diagonal pattern. Either way, spray the hell out of it with a strong-hold hairspray like Redken Forceful 23 Super Strength Finishing Spray, $17 and you'll be good to go for the rest of the night. Here are more pretty versions. Which do you like best?
Go Ahead, Sweep Your Hair To One Side


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Breckenridge PD, CPW confirm mountain lion living in Cucumber Gulch
Officials with Colorado Parks and Wildlife have confirmed the presence of a mountain lion living in the area of Cucumber Gulch in Breckenridge.
The mountain lion has not behaved in a threatening way and has not been visible during daylight hours, according to a Breckenridge Police Department news release.
It is important to note that wildlife, including mountain lions, are not new to Summit County, the release stated.
Breckenridge police issued the following tips for residents living or recreating in mountain lion country:
• Make plenty of noise from dusk to dawn when mountain lions are most active.
• Closely supervise children whenever they play outdoors in areas where mountain lions are active. Talk with children about lions and teach them what to do if they meet one.
• When walking or hiking in lion country, travel in a group and make plenty of noise.
• If a lion is encountered, stay calm, move slowly and speak firmly. Stop or back away slowly if it is safe to do so. Running may stimulate a lion's instinct to chase and attack.
• Appear larger by raising your arms and opening your jacket if wearing one.
• If a lion becomes aggressive, throw stones, branches or anything else in arm's reach to convince it you are not prey and that you are a danger to it.
• Predators follow prey. Do not feed any wildlife.
• Keep your pet under your immediate control. Obey lease laws. Roaming pets are easy prey and can attract lions and other wild animals. Bring pets indoors at night.
• Don't feed pets outside, as it can attract other animals that are eaten by lions. Store all garbage securely.
• Encourage neighbors to follow these simple precautions to prevent a possible lion confrontation.
More tips and information about mountain lions are available online at http://www.wildlife.state.co.us or http://www.townofbreckenridge.com.
Start a dialogue, stay on topic and be civil.
If you don't follow the rules, your comment may be deleted.


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Obama's day: Countdown to default
Only three days left.
With the government set to breach its $16.7 trillion debt ceiling on Thursday -- thereby losing its borrowing authority, setting up a default on its debts -- President Obama has an open day Monday.
The partial government shutdown remains in effect, though much of the government would be closed anyway — it's Columbus Day, a federal holiday.
Obama has not been seen in public since Wednesday, and has no public events on his schedule Monday.
The president has been speaking with members of Congress about the debt ceiling and shutdown negotiations.
He will likely continue to do so as Senate leaders try to work out an agreement to increase the debt ceiling — a deal that would also have to be approved by the Republican-run House, also by Thursday.
Only three days.


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Abiraterone Acetate in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01503229
Recruitment Status : Active, not recruiting
First Posted : January 2, 2012
Last Update Posted : September 19, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Hormone-Resistant Prostate Cancer Metastatic Prostate Carcinoma Recurrent Prostate Carcinoma Stage IV Prostate Adenocarcinoma
|Drug: Abiraterone Acetate Other: Laboratory Biomarker Analysis Other: Pharmacological Study Drug: Prednisone
|Phase 2
I. To determine the magnitude of tissue testosterone suppression by abiraterone acetate in metastatic castrate-resistant prostate cancer (CRPC) (resistant to luteinizing hormone-releasing hormone [LHRH] agonist or orchiectomy ± antiandrogen) after one month of treatment to establish tissue based mechanism of action.
I. To determine the ability of abiraterone acetate to suppress tumor testosterone after 12 weeks of treatment.
II. To determine tissue testosterone from metastasis at time of progression during abiraterone acetate treatment.
III. To determine response to dose escalation of abiraterone acetate at clinical progression.
IV. To determine potential mechanisms of resistance to abiraterone acetate by analyzing pharmacokinetics at clinical progression, tissue androgen levels at baseline and at radiographic progression, evaluating wild type and splice variant androgen receptor (AR) levels at baseline and at time of progression and complementary deoxyribonucleic acid (cDNA) microarray at progression.
V. To determine if micro-ribonucleic acid (RNA) acquired from peripheral blood reflect molecular changes in tumor metastases and are a potential biomarker for mechanisms of sensitivity and resistance.
VI. To evaluate pharmacokinetics of dose escalated abiraterone (abiraterone acetate) at 1000 mg twice daily.
Patients receive abiraterone acetate orally (PO) once daily (QD) and prednisone PO twice daily (BID) on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up periodically.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|28 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Open Label Pharmacodynamic Study of Abiraterone Acetate in the Treatment of Metastatic, Castration Resistant Prostate Cancer
|Actual Study Start Date :
|December 2012
|Estimated Primary Completion Date :
|March 12, 2020
|Estimated Study Completion Date :
|March 12, 2020
Experimental: Treatment (abiraterone acetate and prednisone)
Patients receive abiraterone acetate PO QD and prednisone PO BID on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Drug: Abiraterone Acetate
Given PO
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Other: Pharmacological Study
Correlative studies
Drug: Prednisone
Given PO
Other Names:
- Change in tissue testosterone, dihydrotestosterone (DHT), androstenedione and dehydroepiandrosterone (DHEA) [ Time Frame: From baseline to week 4 ]Tissue testosterone, DHT, androstenedione, and DHEA measurements will be summarized numerically and graphically using plots of patient- and cohort-specific longitudinal patterns and side-by-side boxplots at each time point. A 2-sided paired t-test will be used and an attained significance level of 5% will be considered statistically significant.
- Ability of abiraterone acetate to suppress tumor testosterone, assessed by changes in testosterone levels [ Time Frame: From baseline to 12 weeks ]
- Potential mechanisms of resistance to abiraterone acetate, determined by assessment of changes in tissue androgen levels, evaluating wild type and splice variant AR levels, and cDNA microarray [ Time Frame: Baseline and time of progression, up to 4 years ]
- PSA response to dose escalation of abiraterone acetate, defined as decline from the PSA at initiation of therapy and with dose escalation of abiraterone acetate, assessed using Prostate Cancer Working Group 2 criteria [ Time Frame: Up to 4 years ]The subsequent response to dose escalation (if any) will be correlated with tumor androgens.
- Reflection of molecular changes in tumor metastases by microRNA (miRNA) acquired from peripheral blood [ Time Frame: From baseline to time of progression, up to 4 years ]Candidate miRNA strongly associated with response or progression will be quantitated in biopsy tissue as possible.
- Tissue testosterone from metastasis at time of progression [ Time Frame: Up to 4 years ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Have signed an informed consent document indicating that the subjects understands the purpose of and procedures required for the study and are willing to participate in the study
- Written authorization for use and release of health and research study information has been obtained
- Be willing/able to adhere to the prohibitions and restrictions specified in this protocol
- Able to swallow the study drug whole as a tablet
- Willing to take abiraterone acetate on an empty stomach; no food should be consumed at least two hours before and for at least one hour after the dose of abiraterone acetate is taken
- Patients who have partners of childbearing potential must be willing to use a method of birth control with adequate barrier protection as determined to be acceptable by the principal investigator and sponsor during the study and for 1 week after last dose of abiraterone acetate
- Histologically proven adenocarcinoma of the prostate
- Eastern Cooperative Oncology Group (ECOG) performance status =< 2
Metastatic castration resistant prostate cancer as defined by serum testosterone < 50 ng/ml and one of the following:
- Prostate specific antigen (PSA) level of at least 2 ng/ml that has risen on at least 2 successive occasions at least 1 week apart
- Evaluable disease progression by modified RECIST (Response Evaluation Criteria in Solid Tumors)
- Progression of metastatic bone disease on bone scan with > 2 new lesions
- Maintenance of Lupron or antagonist unless previously treated with orchiectomy
- The presence of metastatic disease amenable to computed tomography (CT) or ultrasound guided biopsy; this may include thoracolumbar vertebral bodies, pelvis, femur or humerus, or soft tissue or nodal metastasis amenable to biopsy (excluding lung or pleural lesions)
- Patients may have received secondary hormonal manipulations (excluding prior abiraterone acetate, MDV3100 or TAK700) or up to two lines of chemotherapy; all prior therapy except Lupron must have been discontinued for more than 4 weeks before enrollment
- Serum potassium of >= 3.5 mEq/L
- Aspartate aminotransferase (AST), alanine aminotransferase (ALT) < 1.5 x upper limit of normal (ULN)
- Bilirubin levels < 1.5 x ULN
- Serum albumin of >= 3.0 g/dL
- Total bilirubin =< 1.5 x ULN
- Calculated creatinine clearance >= 60 mL/min
- Platelet count of >= 100,000/uL
- Absolute neutrophil count of > 1,500 cell/mm^3
- Hemoglobin >= 9.0 g/dL
Exclusion Criteria:
- Active infection or other medical condition that would make prednisone/prednisolone (corticosteroid) use contraindicated
- Patients who are currently receiving active therapy for other neoplastic disorders will not be eligible
- Patients with histologic evidence of small cell carcinoma of the prostate will not be eligible
- Known brain metastasis
- Uncontrolled hypertension (systolic blood pressure [BP] >= 160 mmHg or diastolic BP >= 95 mmHg); patients with a history of hypertension are allowed provided blood pressure is controlled by anti-hypertensive treatment
- Active or symptomatic viral hepatitis or chronic liver disease
- History of pituitary or adrenal dysfunction
- Clinically significant heart disease as evidenced by myocardial infarction, or arterial thrombotic events in the past 6 months, severe or unstable angina, or New York Heart Association (NYHA) class II-IV heart disease or cardiac ejection fraction measurement of < 50 % at baseline
- Atrial fibrillation, or other cardiac arrhythmia requiring medical therapy
- Administration of an investigational therapeutic within 30 days of screening
- Patients with dementia/psychiatric illness/social situations that would limit compliance with study requirements or would prohibit the understanding and/or giving of informed consent will not be eligible
- Patients with any condition that, in the opinion of the investigator, would compromise the well-being of the subject or the study or prevent the subject from meeting or performing study requirements
- Patients requiring therapeutic anticoagulation (e.g., warfarin, dabigatran, heparin, or low molecular weight heparins [Lovenox, dalteparin])
- Patients with poorly controlled diabetes
- Patients with a history of gastrointestinal disorders (medical disorders or extensive surgery) that may interfere with the absorption of the study agents
- Patients with a pre-existing condition that warrants long-term corticosteroid use in excess of study dose
- Patients with known allergies, hypersensitivity, or intolerance to abiraterone acetate or prednisone or their excipients
- Child-Pugh class B or C hepatic impairment
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01503229
|United States, Washington
|Fred Hutch/University of Washington Cancer Consortium
|Seattle, Washington, United States, 98109
|Principal Investigator:
|Robert Montgomery
|Fred Hutch/University of Washington Cancer Consortium
|Responsible Party:
|University of Washington
|ClinicalTrials.gov Identifier:
|NCT01503229 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
NCI-2011-03745 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
7639 ( Other Identifier: Fred Hutch/University of Washington Cancer Consortium )
P30CA015704 ( U.S. NIH Grant/Contract )
|First Posted:
|January 2, 2012 Key Record Dates
|Last Update Posted:
|September 19, 2019
|Last Verified:
|September 2019
Prostatic Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Genital Diseases, Male
Prostatic Diseases
Abiraterone Acetate
Anti-Inflammatory Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Antineoplastic Agents, Hormonal
Antineoplastic Agents
Steroid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Hormone Antagonists
Cytochrome P-450 Enzyme Inhibitors


text:
"Odd Man Out": The Blogosphere Reacts to NYT Article
Earlier today I posted an entry about an article in today's New York Times which alleged that "many portions of [Odd Man Out] are incorrect, embellished or impossible."
Several professional blogs have reacted to the story. Here are a few.
Regarding the latter, blogger Jeff Bercovici wrote:
Of course, for now, the author is sticking to his script, insisting there were, at most, a "handful of details" he might've invented to fill in memory gaps. But we've all seen how this plays out. The publisher — Viking, in this case — will dig in for a couple days as pressure mounts; then it will flip, toss McCarthy overboard and apologize to all and sundry.
Some of these bloggers have referred to A Million Little Pieces, author James Frey's biography about his recovery from supposed alcoholism, drug addiction, and crime. The 2005 book, which earned Frey an appearance on Oprah, was exposed by TheSmokingGun.com to be a fraud.
Police reports, court records, interviews with law enforcement personnel, and other sources have put the lie to many key sections of Frey's book. The 36-year-old author, these documents and interviews show, wholly fabricated or wildly embellished details of his purported criminal career, jail terms, and status as an outlaw "wanted in three states."
Bercovici wrote last December about a phony Holocaust memoir and commented:
With the book business in a deep swoon, no one is going to seriously consider adopting measures that could add tens of thousands of dollars to the cost of publishing a title. And the lesson of Frey's "A Million Little Pieces" was that readers don't necessarily care whether a memoir is true as long as it packs a punch.
Still, while across-the-board fact-checking may be off the table, publishers interested in avoiding future humiliations would do well to take a page from the world of journalism. Here's a little piece of advice every reporter hears not long after starting out: When a story sounds too good to be true, it usually is.
Bercovici noted that the fake Holocaust book and another work about life in gangland L.A, that also turned out to be bogus were both published by Penguin — the same subsidiary of Viking that published Odd Man Out.
His December column was titled, "Phony Holocaust Memoir Won't Be the Last."
He was right.
UPDATE 7:45 PM PST — More articles on the New York Times revelations:
NBC Philadelphia "Baseball's Million Little Pieces".
Village Voice "Times Pounces on Bogus Memoir, But Still Protects Another".
The Sporting News "Baseball Memoir Turns Out To Be Fiction".
DeadSpin.com "Crazy Baseball Memoir Probably Didn't Happen".
PowellsBooks.Blog "Mound of Lies".
Ron Kaplan's Baseball Bookshelf.
Examiner.com "Matt McCarthy's Baseball Memoir Stirs Questions About Truth-Telling".
Can't Stop the Bleeding "First Do No Harm To Easily Checked Facts: The Times on Matt McCarthy's Memoir".
About.com "Odd Man Out book under attack."
IrishTimes.com "Doctor's tall tales fail to stand up to examination".
The Common Man "Faulty Memories".
The Perpetual Post "Odd Man Out, or Who Do You Trust?"
Examiner.com "Washout pitcher's book revealed to have massive errors".
IvyGate "Kaavya Meets Aleksey Meets A Million Little Pieces".
LibraryJournal.com "Another Memoir in Trouble? Baseball and Lilacs".
SantaFeNewMexican.com "Anti-Fan: Despite advice, I forge ahead".
BookListOnline.com "The New York Times: It Giveth and It Taketh Away".
Yahoo! Finance "Odd Man Out is this year's all-star baseball book".
InsideCatholic.com "What's The Truth Worth, Anyway?".
Along with plenty of posts on amateur blogs across the nation …


text:
St. Stephan's Day Lyrics
I stumbled into Merrion tow to listen to a tune. I fought my way down Grafton by the rising of the moon. I sat on the floor of my poxy room just me and the BBC eating bachelor's beans out of the tin, there's nothing here for me. And a rovin' you will go. You are not the one she wants. You are just a ghost from an evening haunt and a rovin' you will go. And you wish that she would stay for now your day is empty and it's just another day. I put my pen to paper but there's nothing to be said. I might as well be in the desert with a turban on my head. I could go to Trader John's or I could shower and could shave. I could go on up to Wicklow and throw a rose on Ronnie's grave. I drank until my bones shook and gathered all my pay. I stood outside the locked up bar along the bachelor's quay. I had absolutely forgotten that it was Christmas day and now there's nothing open and there's nothing left to say. And it's only Christmas day. And it's just St. Stephen's day.


text:
Our guide to all the rumours, news and speculation surrounding the Apple iPad Pro, which is expected to feature a larger screen and be priced above the iPad Air.
Expected Key Features:
- 12.9in screen with 4K resolution
- Priced between iPad Air and MacBook Air
- October 2014 release date
LAST UPDATED: 24 December
As soon as Apple named its latest iPad the Air, it was immediately obvious a Pro model would soon join the lineup. Following in the footsteps of the company's MacBook lineup, a larger, more powerful and more expensive Pro model would fit neatly above the current Air and mini.
Add this logic to an increasing mass of rumours claiming Apple is working on tablets larger than the 9.7in iPad Air, and a Pro being released in 2014 seems a foregone conclusion.
Apple iPad Pro: Design
We're yet to see any leaked photos of the iPad Pro, but you'd be brave to bet against Apple adopting a similar style for the Pro as it has for the Air and mini. This means glass on the front, aluminium on the back, and a chrome chamfered edge around the sides.
Given the new Air mimics the mini's narrower screen bezels, we'd expect the Pro to get a similar treatment, but its extra size and a focus on work rather than play could negate the need for making portability the device's forte.
If portability isn't as crucial to the iPad Pro as it is to the two smaller models - and work is very much on the agenda - we wonder if Apple will give the larger tablet an integrated stand, similar to that of the Microsoft Surface 2. Then, the Pro could be seen as Apple's entry-level work machine filling the gap between tablet and computer.
Apple iPad Pro: Screen [UPDATED]
Stepping away from the realms of pure speculation, various sources familiar with the company's supply chain claim Apple is experimenting with 12.9in displays for use in a tablet.
Speaking to Chinese website Pad News, the unnamed insiders claim Apple is working on prototypes with 2K and 4K screen resolutions; while the former seems unlikely given the iPad Air's resolution of 2048 x 1536, a 4K or Ultra HD iPad makes sense, as it would take Apple ahead of high-resolution rivals like the Kindle Fire HDX.
Apple's tablet for professionals could have a resolution as high as 4096 x 3072, double that of the iPad Air and producing a pixel density of 397 pixels per inch, much higher than the Air's 264ppi.
The news tallies with reports from the Wall Street Journal, which said in July that Apple is working on a new tablet measuring "slightly less than 13 inches diagonally."
This was followed in September by reports that Apple manufacturing partner Quanta Computer was helping to create a 12in iPad; the company has previously worked with Apple on its iPod range and the MacBook Air.
The iPad Pro's screen will no doubt be its defining feature, and offering a 4K Ultra HD resolution would be the PR boost Apple needs, having not updated the regular iPad's screen for almost two years.
UPDATE: On 23 December, Chinese publication DigiTimes also stated Apple is developing a 12.9in iPad Pro, which it believes the company will aim at the North American educational market.
Apple iPad Pro: Processor
A complete unknown for now, the processor Apple chooses will likely depend on the iPad Pro's operating system - will it get iOS, or will Apple bet big and bring OS X to the professional tablet?
iOS has always felt worse on the iPad than on the iPhone, and adding an extra three inches of screen space will start to make the operating system feel incredibly (and unnecessarily) spread out. Apple's earliest tablet prototypes, created before the iPhone was even considered, envisioned a touch-optimised version of Mac OS X running on a MacBook-sized tablet - a return to such a device must surely be on the minds of Apple staff.
By bringing OS X to the iPad, Apple would be firing a direct shot at Microsoft and its Surface 2, which runs the widely disliked Windows 8 RT.
Expect to see 3GB or even 4GB of RAM, and storage options somewhere between 64GB and 256GB, with a 4G option for £100 more.
Apple iPad Pro: Price
The iPad Air starts at £399, while the cheapest MacBook Air (Apple's 'budget' laptop) comes in at £849 - there's a huge gap here for a new tablet, and Apple's continuous merging of iOS and OS X points neatly towards the software it could run.
Expect prices to range from £500 to £1,000, but again this is purely speculative for now, based on Apple's current offerings.
Apple iPad Pro: Release Date [UPDATED]
An announcement to coincide with the Mac's 30th birthday in late January would be superb timing, but at less than two months away this seems unlikely given the lack of leaks thus far.
Apple and other technology companies test and develop prototypes which never see the light of day, so news that devices with 12.9in screens are floating around Apple's factories doesn't mean a launch is imminent - but we fully expect an addition to the iPad family sometime in 2014, a claim backed up by industry sources speaking to the Korea Times in November.
UPDATE: Sources of DigiTimes claim the larger iPad will go on sale in October, 2014, and its performance is "expected to be a major factor as the tablet is being considered as a substitute of the 11-inch MacBook Air."
Read More:


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text:
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Congratulations to Alisa of One Frugal Foodie for winning the potato soup and salad challenge with this lovely Creamy Potato Miso Soup. She certainly had some tough competition.
I'm especially eager for Spring right now and after much thought, decided to focus on a cuisine from a warmer area of the globe and to go with a theme that falls in line with my specialty. For March, the challenge is to come up with an Indian or Indian-style vegetarian soup or salad. Soupy dal dishes are also welcomed. You have until the 20th to email us your entry. For a recap of the submission guidelines, please go here.
No Croutons Required - The Winner for February and the Theme for March
Posted by Lisa Turner on Sunday, March 01, 2009
6 comments:
- Bellini Valli said...
Congratulations to the winner Lisa. I lopk forward to March:D
- March 1, 2009 at 5:24 PM
- Holler said...
Good challenge Lisa! I am liking my soup spicey, so this one will be spot on for me :)
- March 1, 2009 at 5:45 PM
- Ivy said...
Congrats to the winner. The soup does look delicious. Must see if I can find any Indian style soups.
- March 3, 2009 at 3:30 PM
- Anonymous said...
Nice event coming up. I am looking forward to send my entry!
- March 6, 2009 at 10:31 AM
- VnV said...
Just so happened we made 3 soups last weekend, 2 of them Indian style! So I sent in my entry.
- March 9, 2009 at 2:37 PM
- Soma said...
Just sent in my entry Lisa.
- March 13, 2009 at 9:13 AM
Subscribe to: Post Comments (Atom)


text:
Thanks to The Daily Post for the word prompt fearless yesterday. Also, thank you to The Daily Post for today's word prompt footsteps.
You said, be fearless.
Some fears are hard to conquer,
Nothing to fear but fear —
Itself, it's said all the time.
No one knows how hard it is.
Be brave; be bold,
Fearlessness is born fraught,
With thoughts running wild,
I'm terrified inside to try,
Conquering fears is difficult.
May your footsteps lead,
You on the path, being —
Someone who isn't —
Afraid of what the future —
Holds, because we're all human.
Don't be scared to go,
Where ever your footsteps need,
Time will tell you step,
Leap, don't be full of fear.
Life for the living, is hope.
Don't be afraid our —
Saviour said, be strong.
On earth, we fight hard.
Life is a while we are breathing.
Breath, have faith, it will work out.
Days our tough, tiring.
Follow where He leads us fearless.
You're in no danger.
He lights pathways taken, beams–
Lustrous light leads.
Telling you where,
To place each footstep, travel
Where He knows, we go,
Unafraid, fearless,
We're strong, He's with us always.
©Mandibelle16. (2016) All Rights Reserved.


text:
Asked by Kayla, North Carolina
Hi, I got multiple sclerosis about a year ago, and I'm very young. I was curious if there has been any further information about a possible cure or not. I know that people have been searching for a cure, but I'm curious as to how close they really are.
Conditions Expert
Dr. Otis Brawley
Chief Medical Officer,
American Cancer Society
Multiple sclerosis is a neurologic disease that affects women more often than men. Onset is most commonly in the 20s or 30s.
MS is an autoimmune disease in which there is initially focal inflammation and then permanent damage to nerves of the central nervous system. The damage is really removal of the insulating material surrounding nerves. The tissue that insulates nerves is called myelin, and the damage is referred to as demyelination.
As a nerve that controls sensation or movement of a part of the body loses some of its myelin covering, the nerve may become dysfunctional. This can manifest itself as loss of that nerves function which can be sensation, vision, movement or coordination of movement. Affected sensory nerves can also cause pain.
There have been tremendous advances in our ability to diagnose and assess MS with the development of magnetic resonance imaging. Unfortunately, our understanding of the cause of this disease remains limited, as does our ability to treat it. There is some limited success in stopping or decreasing the severity of an MS attack. We would also like to stimulate a regrowth of the damaged myelin over the nerve. Unfortunately, this is not possible at this time.
There are several types of MS. Some patients have disease that will have an acute exacerbation followed by a prolonged quiet period, which can last years or decades. This form of disease is referred to as relapsed remitting MS, or RRMS. Others have a disease that gets progressively worse over time. There are two types of progressive disease. In primary progressive MS, or PPMS, symptoms steadily worsen over time from the very beginning. Secondary progressive MS, known as SPMS, begins as relapsed remitting disease and becomes progressive over time.
For an acute exacerbation of multiple sclerosis that can result in neurologic symptoms and increased disability or impairments in vision, strength or coordination, the preferred initial treatment is usually a type of steroid called a glucocorticoid. Patients who do not have a good response to steroidal therapy are often treated with plasma exchange. Plasma exchange is an extreme therapy that removes antibodies to myelin from the blood.
Patients with RRMS are often treated with immune-modulating drugs such as interferon or glatiramer acetate. Glatiramer is an exciting drug. It is a series of small proteins that are similar to myelin protein. It is thought to prompt the immune system to avoid attacking myelin.
Available treatments of primary and secondary progressive MS are of limited efficacy and have significant side effects. An additional fact to consider is that most trials have not lasted longer than two or three years and give only hints about long-term results of treatment.
In brief, no clinical trial has shown convincing evidence of benefit in the treatment of primary progressive MS. All suggested treatments for PPMS are empiric. Several drugs that are more commonly used in the treatment of malignancy, cladribine and mitozantrone, appear to have some activity.
In contrast, there is definite modest benefit in some treatments for secondary progressive MS. These treatments include various regimens of steroid therapy and the use of some drugs that modulate the immune system. Many of these drugs are more commonly used in treatment of cancer and rheumatoid arthritis such as cyclophosphamide, methotrexate and interferon.
MS should be treated by a neurologist with experience in managing it. The American Academy of Neurology has published treatment guidelines for MS.
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text:
The United States is coming off one of its most successful Olympic Games ever: The 121 total medals, including 46 gold, were the third-most ever for the U.S., and more than 50 medals ahead of any other country. The U.S. passed the 1,000 gold medal mark all-time, and 2,500 total medals.
Take an in-depth look at how the United States pulled off the feat, and how other countries fared.


text:
Our Advanced Search is the quickest way to find the perfect Jersey or Guernsey self catering holidayAdvanced Search
Sleeps 4 (+1)
or near here
Facilities at Farm Based Apartments, St Pierre Du Bois
click here to see other units at this property
THE DELIGHTFUL SETTING of a livery stables of 11 acres in St Peter adds to the appeal of this farm style property. The elevated position provides views across the countryside to the sea together with a peaceful green valley to the rear of the property adds to the general ambience.
There are many country walks along the lanes and paths around the vicinity. L'Eree bay is is approximately 10 minutes walk away through beautiful lanes. A choice of other wondeful beaches are under 10 minutes drive. The village is 5 minutes drive where there is a small supermarket, bank, post office, hairdressers and dry cleaners.
The owners are true animal lovers and have two Golden Guernsey goats, 3 dogs and also two cats along with horses. Guests pets are accepted in Mirus Cottage or The Wing only. All in all a great holiday location in a unique setting.
Portelet - 2 Bedroom Apartment - Maximum 4 adults, 1 child, 1 infant.
First floor: Lounge-kitchen-diner. 1 Double/twin bedroom. 1 Twin bedroom with roll-out single bed. Bathroom. Space in the twin bedroom becomes limited when 3 persons are accommodated.
More about the accommodation
Hairdryer. Children welcome. Infants accommodated free, otherwise nominal charge of 50 pounds per person per week if 5 persons are accommodated in a 2 bedroom. Pay phone available. Pets accepted in Mirus Cottage & The Wing only.
What is provided
Top Tip! Make a list of the accommodation reference numbers that appeal.


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How did we get halfway through the season already? Where did my life go? Why was there no Tyrion this episode? And what is this rash?
No matter, I'm sure the itching will stop. And it's best to be a glass half full kind of gal and remember there are still five episodes to go. Also, Jon Snow totally skewered a guy through the face with his sword, which was horrible and awesome.
This was another slow-burner of an episode, which might have annoyed some of you, my beloved Throners. But it was a lovely character study, full of small decisions, big revelations and a great dollop of comeuppance to finish off.
Reminder: spoilers will be included below, so only read on if you've seen the episode. We're discovering the storyline through the TV series (reading the books after each has finished), so no dropping important future plot points in the comments, or we'll totally skewer you in the face because that is horrible and awesome).
So is it wrong that I found myself a bit cranky at not seeing Lysa Arryn creepily breastfeed her son? Don't get me wrong, I'm glad the loopy Lady of the Vale has stopped spearing the chest kegs for someone who is well onto his adult teeth. But I'm so battle-hardened by this show now, that I was kinda hoping she'd roll out the barrels just so I could yell "Your breasts don't scare me!", which incidentally is how I like to be asked out (hint, hint).
Lysa has been hanging at the Eyrie since we last saw her in season one, but while her fortress remains impenetrable, her virtue most certainly isn't. It turns out she's crazy in love with Petyr Baelish, and the pair have been in machiavellian cahoots for some time.
That is to say she thinks they've been in cahoots, but no doubt Littlefinger is playing her like a crazy fiddle in his own special way. By the gods that man is slimy. Even the way he pashes is creepy. He's a mouth-coverer, which is never good. I appreciate it's a metaphor for how he's trying to shut Lysa up and not talk about the whole "We did the nasty so I totally killed my husband and lured Ned Stark into a trap for you" plan, but still, leave some breathing room, dude.
Lysa gives the term "crossbow wedding" new meaning by having a sept pop straight in and marry them, declaring that she's going to scream so loud when they re-consummate their relationship that they'll hear her across the Narrow Sea. Poor Sansa, just a stone's throw away, had such trouble trying to sleep that she probably spent the rest of the night inventing soundproofing and therapy.
It gets worse for Sansa, because despite Lysa's initial warm welcome, she's soon pinned her niece to the lemoncake tray demanding to know why her new husband is so concerned for Sansa's safety.
Only after Sansa yells "Virgin!" more times than Richard Branson at his first brand development meeting does her aunt relax, comforting Sansa with the knowledge that soon Tyrion will be dead and she can marry her cousin Robin. Oh, joy.
Back in King's Landing, Joffrey is being fondly remembered by absolutely no one, as they applaud the ascension of his brother Tommen. The teen greets his subjects with grace and humility (nice to see Pycelle and Varys popping their heads up briefly), while simultaneously trading goo-goo eyes with Kate Middleton.
I thought Cersei was about to launch another bitchkrieg on Margeary, but instead she does something strange and unnerving - she's nice to her. Cersei admits Joffrey was a terrible human being, she loved him anyway because he was her first born, but really Tommen will be much better and perhaps Margaery would be interested in re-applying for the role of Queen?
Cersei then has what can only be described as a civilised conversation with her father, in which she seems resolved to marry Margaery's brother Slow Loris for the good of the family. Tywin drops a truth bomb of his own - the Lannisters' gold mines are kaput and they're all broke. They need the Tyrells like James Packer needs a title fight.
There was more grave discussion of the Iron Bank of Braavos, a plotline that's coming into clearer view now that Stannis Baratheon looks set to appeal to the bank for funding (Stannis' absence again this week indicates a lengthy queue at his local branch).
Then there's Cersei's chat with Inigo Montoya, whom she interrupted while he was composing a poem (If you're up for it, why not compose your own Game of Thrones-inspired limerick and leave it in the comments?). The pair discuss the troubles of parenthood, and the feeling of helplessness when one cannot protect one's family. Oberyn tells Cersei that her daughter Myrcella is very happy in Dorne, but Cersei feels she'd be happier with a big-ass sailboat.
Now maybe Cersei is just orchestrating all this relative niceness to convince her father and Martell to find Tyrion guilty of Joffrey's murder, but I'd like to think she's made some sort of conscious decision to not be a complete cow for a while.
There's plenty of tension over in Meereen, where Daenerys is faced with rebellion in Astapor and Yunkai, the cities whose slaves she just liberated.
Meanwhile Maario has swiped her 93 ships, which should earn him a lot of gold coins and the ability to throw fireballs, but instead causes more consternation about whether her army is big enough to take Westeros.
Dismissing her council, Dany confides to Jorah Mormont that no one will trust her if she can't keep her freed people safe. So she decides to do what queens do and rule, which seems to indicate we'll be in Meereen for a while yet. Dany's dragons haven't showed their scaly faces for a few eps now, so we can only imagine producers are saving their CGI dollars for something spectacular.
There's a lovely sequence with Brienne and Pod as they start their road trip together. It turns out Pod has no idea how to skin a horse or ride a rabbit, and certainly not the other way around.
Brienne keeps trying to get him to sod off, but Pod is determined to be a proper squire. Brienne's resolve is softened when he reveals he killed a Kingsguard to protect Tyrion. All of a sudden Brienne realised that loyalty was perhaps a better foundation for a good squire than the ability to cook, and let Pod remove her armour.
Fighting was also the topic of choice for Arya and The Hound, who are still on their way to the Eyrie. Sandor Clegane discovered Arya's bedtime routine of reciting her To-Kill list, prompting a delightful spray of invective.
He wakes to find Arya gone, but soon discovers her practising her water dancing by a river (metaphor). She defends her training as being the best in the world, but after Needle bounces off the Hound's chestplate, he knocks her to the ground and tells her that real fighting involves armour and a "big f*ing sword". Hard to argue, really.
Finally, it's time for the horrible mutinous Crows to get what's coming to them, hopefully in the most brutal manner possible.
Locke is the Crow sent off to scout ahead, and spies Bran and the Scooby gang tied up in a hut. Cunningly, he tells Jon Snow and the rest to avoid it, saying the dogs inside will smell them out.
Of course, Locke's plan is to make off with Bran, to rid him as a rival to Roose Bolton. But Bran is quick enough to take over control of Hodor's body, using the giant's strength to break free and perform extreme chiropractic manipulation on Locke's neck.
There was a heartbreaking scene where Bran crawled towards Jon, who was fighting heroically in the firelight, his carved physique poetry in motion (somebody bring me a fan). He was calling out for his brother, but Jojen convinced him that Jon would not allow him to go further north, and the pair both knew Bran had to get to the great heart tree of their visions for reasons that I'm sure will become clear at some point in about two series' time. It was the closest two Starks had been in ages, but Bran chose to put duty before family.
Inside Craster's Keep, Jon finds Karl Tanner, the leader of the motley crew, and the pair fight hard until Tanner is knifed by one of the daughter-wives. He's about to strike back at her when SLICE! The sharp point of Longclaw appears from Tanner's mouth. Jon Snow totally skewered his face with a sword, and it was horrible and awesome.
Jon was reunited with Ghost, whom he hasn't seen since Series Two, and the sister-wives made the call to burn the whole damn keep to the ground. Battered and bruised, the women were not broken, and refused Jon's offer of help to find their own sort of safety.
Zing! Best Lines
"I bet his hair was greasier than Joffrey's c!#&"
The Hound's assessment of Sylvio Forel can't really be topped.
Yay! Best Moments
I imagine I wasn't the only person who felt punched in the guts by Cersei's aching summary of inequality: "All over the world they hurt little girls."
I know I don't normally go into serious real world stuff in what's supposed to be a funny recap, but with the shocking and unconscionable enslavement of hundreds of Nigerian schoolgirls on my mind, this line was enough to make me choke back a breath. It was heart-wrenching, and it was beautifully done.
Ewww, gross
Karl Tanner's toe-curlingly horrid assault on Meera, and his declaration that his deputies can have "what's left of her". Jojen's taunts that he would die that night were glorious, and I'm so glad Tanner took a sword through the face.
No Tyrion! Barely any Jaime! Not a single boob or wang! Denied!


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Thanks to Alastair Forbes for holding this week's SPF.
The White Horse is a popular bar and inn for tourists to stay at while visiting museums and decaying buildings in town.
Many old ones have been restored in the style of their time period. However, some buildings have rotted away. These past glories are left in ruin because they cannot be torn down as historical sites.
Although some people wish to restore these ancient buildings, the process of doing this correctly, with trades who are trained in forgotten skills, is frustrating. As well, there are a plethora of permits needed from the city, county, and state, along with, random inspections.
Architects and knowledgable art history professors complain, saying that the quality of work by rare trades is not accurate. Or perhaps, they say the right materials have not been used, despite these materials now being nonexistent. But few so-called experts understand that the price paid for not restoring ancient buildings is having them collapse, having history disappear.
The White Horse, however, is an exception to such procedures. The popular bar and inn has been passed down from generations of family since the thirteen-hundreds. Over time, the same lineage has updated the bar and inn through each successive family. The building contains upgrades from the fourteenth century until early 2010.
For some reason, there isn't much any government official or anyone else, can say about this. The same family line has lived here for over seven-hundred-years, having always owned the bar and inn. Can the state and historical societies reprimand them now? Not likely.
©Mandibelle16. (2017) All Rights Reserved.


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Dear Abby: My husband committed suicide 21/2 years ago. We had been married for 13 years and had two daughters who are now 15 and 9. The l5-year-old seems to be doing fine. The 9-year-old is not.
But my biggest problem is my live-in boyfriend, "Tim." While I love him and mostly enjoy his company, he appears to dislike my 9-year-old. She needs male attention because her dad was an attentive, wonderful father. I have discussed this with Tim. His response is he has a hard time doing it because she is "totally out of control and crazy."
Abby, she is none of that. She is a child with a lot of energy. I don't know what to do. I know it isn't fair to my daughter, but I'm lonely and miss Tim when he's not there. - Trying to Move On in Ohio
Dear Trying: I am so sorry for your loss. However, parents get only one chance at parenting, which is why it's so important to do it right the first time. What is happening in your household is unfair to your daughter. She should not be forced to live with a man who doesn't like her and can't give her positive reinforcement. If you choose him over your daughter, you will later regret it and could cause her serious emotional problems for decades.
Dear Abby: The holidays are right around the corner, and my husband and I have had a difficult couple of years financially. I'm a full-time student; he is the only one bringing in an income while we raise two young boys.
I love the holidays - except for shopping for others. I hate spending money I don't have looking for that perfect gift for everyone on my list. More often than not, the gift ends up being re-gifted or in the summer garage sale. For the past two years I have asked that if people want to give gifts, to please give them to the kids and leave us adults out of it. My requests have been ignored.
I know for a fact that my extended family is as strapped for cash as I am, but they charge on credit cards. Should I refuse a gift I can't reciprocate, or thank them and try not to feel guilty? The name exchange option didn't work.
I feel there should be more to the holidays than going into debt for gifts. - Ma Humbug in Oregon
Dear Abby is written by Abigail Van Buren, also known as Jeanne Phillips, and was founded by her mother, Pauline Phillips. Write Dear Abby at www.dearabby.com or P.O. Box 69440, Los Angeles, CA 90069.


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The lawyer for a black woman whose hostile workplace claim against a black boss's N-word rant produced a $280,000 jury award says she hopes the case teaches society something.
"It's the most offensive word in the English language," attorney Marjorie M. Sharpe said outside federal court in Manhattan after a jury Tuesday added $30,000 in punitive damages to go with a $250,000 compensatory damages award it imposed last week against STRIVE East Harlem and founder Rob Carmona.
Sharpe stood with her client, 38-year-old Brandi Johnson, after a jury of six men and two women determined Carmona owes her $25,000 and STRIVE $5,000 in additional damages in a case that put a legal microscope to the concept that the word that is a degrading slur when spoken by whites can be used without retribution and sometimes affectionately among blacks, even in the workplace.
Sharpe said the double standard had persisted far too long as "people have tried to take the sting away from the N-word."
Johnson said she hopes the word now "won't be tolerated no matter what your race is."
Carmona, a 61-year-old black man of Puerto Rican descent, had testified at the trial that he was dispensing tough love in language he faced from counselors who turned him from a drug addict with an arrest record into the creator of an often-praised organization that has helped nearly 50,000 hard-to-employ people find work since 1984.
Johnson had recorded the March 2012 tirade about inappropriate workplace attire and unprofessional behavior that was aired for the jury and described by both sides as the trial's centerpiece. She said she cried for 45 minutes in the restroom afterward.
"I was offended. I was hurt. I felt degraded. I felt disrespected. I was embarrassed," Johnson testified.
Outside court after her victory, Johnson said she was "very happy" and rejected Carmona's claims from the witness stand Tuesday that the verdict made him realize he needs to "take stock" of how he communicates with people he is trying to help.
"I come from a different time," Carmona said hesitantly, wiping his eyes repeatedly with a cloth. Sharpe told jurors they were "ghost tears."
"So now, now you're sorry?" Johnson said outside court, adding she doubted his sincerity and noting Carmona had refused to apologize to her in court last week. She said he should have been sorry "the day when he told me the N-word eight times."
Carmona left the courthouse without immediately commenting, as did all eight jurors. When he testified last week, he tried to defend his use of the word, saying it had "multiple contexts" in the black and Latino communities, sometimes indicating anger, sometimes love.
In a statement, STRIVE said it was disappointed but was exploring options, including an appeal and looking forward to the "judicial process taking its entire course." A STRIVE executive testified Tuesday that the organization already has changed because of the verdict with plans to provide its staff additional diversity, discrimination and anti-harassment training.
It also cited Johnson as a "prime example of the second chances that STRIVE provides to both its participants and nonparticipants alike."
It noted that Johnson, who was never a STRIVE participant, was employed there despite a previous conviction for grand larceny that required her to pay about $100,000 in restitution. The judge barred lawyers from telling jurors about the conviction.


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Perfect – the ultimate kitchen thermometer (Canceled)
Inspired by professionals, available for everyone with a passion for cooking.
Perfect – the ultimate kitchen thermometer (Canceled)
Inspired by professionals, available for everyone with a passion for cooking.
Funding paused – project proceeds
In agreement with Kickstarter we have decided to pause the funding of this project. Kickstarter have kindly made us aware that we have involved our backers too early in the production process. A "working prototype" must be developed before seeking funding.
We will carry on our work with Perfect according to the production plan available here on Kickstarter. And when we have a working prototype, at the latest in January 2018, we will relaunch.
We hope you will back us then! Thank you for your support and for your patience!
If you love cooking, help us!
Professional Secrets is all about passion for cooking. We make it our business to supply knowledge and tools from the professional kitchen to all cooks. But when we went looking for the best kitchen thermometer we were surprised to find: There wasn't one.
So we decided to create the ultimate kitchen thermometer ourselves, here on Kickstarter.
The money we raise will go towards development, engineering and design of this entirely new product. We have a prototype, but we need the help of passionate home cooks everywhere to make this essential kitchen tool come true.
Please back us. And please help us spread the word to anyone you know who is passionate about cooking!
Perfecting an important kitchen tool
Ask any chef: The thermometer is one of the most important tools in a professional kitchen. It is essential for cooking meat and fish – and when making sauces, desserts, pastries, bread, and more. However:
• Thermometers available to home cooks are generally of poor quality and equipped with a sub-standard, blunt probe that leaves holes in – or even damages – tender food.
• The industrial thermometers (preferred by professional chefs) are, in turn, extremely expensive and also inconvenient. They have been designed for industrial food inspection, not for intense work in the kitchen.
That is why we want to to create the perfect kitchen thermometer for everyone with a passion for cooking.
With the help of professional chefs
In collaboration with talented chefs we listed the most important qualities and details for a kitchen thermometer. We spent an awful lot of time looking for the right technology and – not least – the right probe. And, employing some of the best talent in the business, we worked hard on the design.
The result is "PERFECT". Here's why we were unable to come up with a more humble name for this thermometer:
For a professional it is all about the probe. That is where this instrument comes into contact with food and where measuring takes place. A blunt, clumsy probe can make meat bleed, leave holes in bread, and damage tender fish.
It took some time, but we were able to find just the probe we were looking for:
- Very thin. (Food inspectors can't leave big holes in inspected food.)
- Very accurate. (Food inspection saves lives.)
- Very fast. (For the sake of effectivity.)
Sensitive, cutting edge technology accurately measures decimals.
Measuring decimals can seem a bit exaggerated in a kitchen, but that is not the point. The decimals allow you to follow – in real time – the rise or fall in temperature. With this thermometer you can actually see where your cooking is heading.
The thermometer will be possible to switch between Celsius and Fahrenheit reading.
Always upright reading. It doesn't matter if you are a professional chef or a passionate home cook, everyone has their own style in the kitchen. And ovens are situated on different levels in different kitchens. That is why we gave PERFECT a display that flips (a bit like the screen on your mobile phone) and that works for everyone, everywhere.
The most sensitive part of the thermometer is the thin probe. So we created a sheath – that is also a form of packaging – that keeps it from harm when the thermometer is not in use. The click-on sheath fits snugly in your apron pocket.
Water resistant and hygienic
Hygiene is a must in all kitchens. "Perfect" is water resistant, allowing for effective, easy cleaning under the tap. (But do not wash in dishwasher or submerge under water for a long time.)
For all uses in the kitchen:
Last but not least: The right price
From the very start of this project it has been our intent to make a professional quality cooking thermometer available and affordable for everyone who is passionate about cooking.
The materials used, the technology incorporated and the design applied will be of professional standard. Despite this the price is affordable price and puts PERFECT within reach for all passionate cooks.
Backer rewards
You can choose from a number of exciting Backer rewards that will make it worth your while to support this Kickstarter. We are itching to go ahead with this project and we are going to make great efforts to get your rewards out to you as soon as possible.
Make a difference with your support
By contributing to our project and helping us make this kitchen tool come true, you will not only improve your own cooking with the help of a great cooking thermometer, you will also be helping us in our greater goal: To spread the joy of cooking and a greater awareness of what constitutes good food and the impact it has on people's health and the health of the planet.
Your contribution will be used to:
- Build the prototype
- Compliance testing & Certifications
- Investments in mechanical tooling
- Source components for the first sales batch
- Finalize the design of the Perfect Thermometer
Ways to Contact Us
1. Back our campaign and leave a comment on our Kickstarter page.
2. Send a direct message to us on Kickstarter.
3. For further support, contact email@example.com
Press Kit
If you are a member of the press and need more material, please contact firstname.lastname@example.com
Here's another project you may like
Risks and challenges
The Perfect Thermometer is a complex product with several unique components that leaves us dependant on our suppliers and partners. To lower the risk, we have built up a supply-chain with sourcing partners and manufacturing partners.
Technically there will be obstacles as there always are, but we will tackle them as we go and we will share all our efforts.
Schedule is a risk, depending on so many factors. The main risk though, is poor quality from assembly and mechanical suppliers. We'll reduce this risk by visiting mechanical suppliers and we will be present during product-builds assembly and testing.
Our most important asset is the people who support us, believe in us and make The Perfect Thermometer possible. We want to thank you and we promise you that we will deliver you the The Perfect Thermometer ever used in the kitchen.Learn about accountability on Kickstarter
Funding period
- (30 days)


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Redwork Winter Twitterings
Back by popular demand!
Combine simple embroidery stitches, red embroidery floss plus red and white fabrics, and soon you will have created the sweet designs in this book. Whether you start with the whimsical quilt or make a set of tea towels, these unique designs will be sure to bring a smile to your face as you stitch. Have fun making each of our twittering bird friends and then feature them on the projects we suggest -- or add them to any item you choose. You'll enjoy making these projects to add a special touch to your home -- and they make great gifts! Includes 8 projects; 48 all-color pgs.
Overall rating:
5 out of 5
(1 reviews)
(1 reviews)
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Redwork Winter Twitterings
Cheryl Z
November 6, 2015
November 6, 2015
The motifs in this book were just want I was looking for. I have started embroidering one to a stocking already. Great illustrations and directions. I would recommend this book to all who love embroidery.
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