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New Hydrogel From the Institute of Bioengineering and Nanotechnology and IBM Corporation Destroys Superbugs and Drug-Resistant Biofilms
IBN Executive Director Professor Jackie Y. Ying said, "As a multidisciplinary research institute, IBN believes that effective solutions for complex healthcare problems can only emerge when different fields of expertise come together. Our longstanding partnership with IBM reflects the collaborative creativity across multiple platforms that we aim to foster with leading institutions and organizations. By combining IBN's biomaterials expertise and IBM's experience in polymer chemistry, we were able to pioneer the development of a new nanomaterial that can improve medical treatment and help to save lives."
Dr Yi-Yan Yang, Group Leader at IBN said, "The mutations of bacteria and fungi, and misuse of antibiotics have complicated the treatment of microbial infections in recent years. Our lab is focused on developing effective antimicrobial therapy using inexpensive, biodegradable and biocompatible polymer material. With this new advance, we are able to target the most common and challenging bacterial and fungal diseases, and adapt our polymers for a broad range of applications to combat microbial infections."
More than 80% of all human microbial infections are related to biofilm. This is particularly challenging for infections associated with the use of medical equipment and devices. Biofilms are microbial cells that can easily colonize on almost any tissue or surface. They contribute significantly to hospital-acquired infections, which are among the top five leading causes of death in the United States and account for US$11 billion in healthcare spending each year.
In Singapore, antimicrobial drug resistance is a major healthcare problem because of the extensive use of antibiotics and medical equipment such as intravascular catheters and orthopedic implants in patients. Once in the body, these instruments become potential breeding grounds for bacterial growth. This provides a continuous source of contamination, which could result in prolonged hospitalization, higher medical costs, and greater risk of death. Research has shown that patients in Singapore with microbial infections were 10.2 times more likely to die during their hospitalization, had 4.6 times longer hospitalization, and incurred 4 times higher hospitalization cost compared to patients with no infections. The emergence of new strains of superbugs and shortage of new drugs has exacerbated the need for an effective antimicrobial solution. Traditional household antiseptics and disinfectants are also proving to be ineffective in eliminating drug-resistant germs.
Under Dr Yang, IBN's Nanomedicine group has been conducting research on polymer and peptide nanoparticles as antimicrobial agents since 2007. Her lab has published 15 papers in high-impact factor journals such as Nature Nanotechnology, Nature Chemistry, Nano Today, Advanced Materials, ACS Nano, Biomaterials, and SMALL and filed 10 patents on their antimicrobial technologies.
Recently, Dr Yang's group and their collaborators from IBM Research co-developed a synthetic gel that is biodegradable, biocompatible and cost-effective. With over 90% water content, the hydrogel is highly flexible and easy to adapt for different uses. This gel can target the bacteria and fungi behind seven of the most common hospital-acquired infections such as MRSA (methicillin-resistant Staphylococcus aureus), VRE (vancomycin-resistant enterococcus), multidrug-resistant Acinetobacter baumanniiand Klebsiella pneumoniae, E. coli, Candida albicans and Cryptococcus neoformans fungi.
This new gel is comprised of the novel polymer material jointly developed by IBN and IBM Research in 2010. When mixed with water and heated to body temperature, the polymers form spontaneously into a moldable gel, due to the self-associative interactions between the polymer molecules. This allows the hydrogel to target multidrug-resistant biofilms at various parts of the body and surfaces without being flushed away. Once the antimicrobial function is activated and performed, the biodegradable gel can be naturally eliminated by the body.
Using the new polymer material as a basic building block, IBN can now provide a comprehensive antimicrobial solution to combat drug-resistant bacteria and fungi for a range of medical and consumer products.
"Bacterial biofilms are a serious health threat and the ability to disperse such films is critical. The soft consistency of our non-toxic materials makes them ideal for injectable and topical applications as well as coatings and lubricants for medical devices such as catheters," said Dr James Hedrick, Advanced Organic Materials Scientist, IBM Research. "Whether it's designing degradable materials to eliminate polymers occupying landfills or new antimicrobial hydrogels that don't have drug resistance, our partnership with IBN has allowed us to take what the industry has deemed really important and create solutions that are applicable to many technologies in medicine."
This latest research breakthrough was recently published in the leading peer-reviewed journal, Angewandte Chemie International Edition.
This research is funded by the Institute of Bioengineering and Nanotechnology. ETPL, the technology transfer arm of the Agency for Science, Technology and Research, funded the skin biocompatibility testing of the antimicrobial hydrogel for its commercial development for consumer care.
1. "Y. Li, K. Fukushima, D. J. Coady, A. C. Engler, S. Liu, Y. Huang, J. S. Cho, Y. Guo, L. S. Miller, J. P. K. Tan, P. L. R. Ee, W. Fan, Y. Y. Yang, and J. L. Hedrick, "Broad-Spectrum Antimicrobial and Biofilm-Disrupting Hydrogels: Stereocomplex-Driven Supramolecular Assemblies," Angewandte Chemie International Edition, 135 (2013) 702-706.
2. "S. Q. Liu, C. Yang, Y. Huang, X. Ding, Y. Li, W. M. Fan, J. L. Hedrick and Y. Y. Yang, "Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition," Advanced Materials, 24 (2012) 6484-6489.
3. X. Ding, C. Yang, T. P. Lim, L. Y. Hsu, A. C. Engler, J. L. Hedrick and Y. Y Yang, "Antibacterial and Antifouling Catheter Coatings Using Surface Grafted PEG-b-Cationic Polycarbonate Diblock Copolymers," Biomaterials, 33 (2012) 6593-6603.
For interviews, queries and photo requests, please contact:
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About the Institute of Bioengineering and Nanotechnology
The Institute of Bioengineering and Nanotechnology (IBN) was established in 2003 and is spearheaded by its Executive Director, Professor Jackie Yi-Ru Ying.
Professor Ying was a Professor of Chemical Engineering at the Massachusetts Institute of Technology (1992 - 2005). She was recognized as one of "One Hundred Engineers of the Modern Era" by the American Institute of Chemical Engineers in 2008 for her groundbreaking work on nanostructured systems, nanoporous materials and host matrices for quantum dots and wires.
Under her direction, IBN conducts research at the cutting-edge of bioengineering and nanotechnology. Its programs are geared towards linking multiple disciplines across engineering, science and medicine to produce research breakthroughs that will improve healthcare and our quality of life.
IBN's research activities are focused in the following areas:
Nanomedicine, where functionalized polymers, hydrogels and biologics are developed as therapeutics and carriers for the controlled release and targeted delivery of therapeutics to diseased cells and organs.
Cell and Tissue Engineering, where biomimicking materials, stem cell technology, microfluidic systems and bioimaging tools are combined to develop novel approaches to regenerative medicine and artificial organs.
Biodevices and Diagnostics, which involve nanotechnology and microfabricated platforms for high-throughput biomarker and drug screening, automated biologics synthesis, and rapid disease diagnosis.
Green Chemistry and Energy, which encompass the green synthesis of chemicals and pharmaceuticals, catalytic conversion of biomass, utilization of carbon dioxide, and new nanocomposite materials for energy applications.
IBN's innovative research is aimed at creating new knowledge and intellectual properties in the emerging fields of bioengineering and nanotechnology to attract top-notch researchers and business partners to Singapore. Since 2003, IBN researchers have published over 820 papers in leading journals.
IBN also plays an active role in technology transfer and spinning off companies, linking the research institute and industrial partners to other global institutions. The Institute has a portfolio of over 581 patents/patent applications, and welcomes industrial and clinical partners to collaborate on and co-develop its technologies. IBN has successfully commercialized 46 patents/patent applications, and has established 6 spin-off companies.
IBN's current staff and students strength stands at over 150 scientists, engineers and medical doctors. With its multinational and multidisciplinary research staff, the institute is geared towards generating new biomaterials, devices, systems and processes to boost Singapore's economy in the medical technology, pharmaceuticals, chemicals, consumer products and clean technology sectors.
IBN is also committed to nurturing young talents. Besides the training of PhD students, IBN has a Youth Research Program (YRP) for students and teachers from secondary schools, junior colleges, polytechnics, and universities. Since its inception in October 2003, IBN's YRP has reached out to more than 59,860 students and teachers from 289 local and overseas schools and institutions. Over 1,670 students and teachers have completed research attachments at IBN for a minimum period of four weeks.


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As if the arrival of board shorts and bikini season wasn't enough, there's new evidence about the negative effects of carrying extra poundage on the male body. Fortunately, science is also giving us some cool new tools to deal with our increasingly portly profiles.
The Heart and Stroke Foundation confirms that "almost 60 per cent of all Canadian adults and 26 per cent of our children and adolescents are overweight or obese." So it was no accident that the 9,300 experts who converged recently for the Endocrine Society's Annual Meeting spent a lot of time talking about the obesity epidemic.
Anne Turner and her colleagues from Australia's Deakin University may have found one of the biological roots of overeating. At the San Francisco conference she reported that, at least for obese and overweight men, the simple act of eating triggers secretion of the stress hormone cortisol.
Her numbers were impressive. "Overweight/obese men responded to food intake with a significant elevation (51 per cent) in salivary cortisol" compared to a five per cent increase in lean men. "If overweight/obese men have an elevated cortisol response every time they ingest food," Turner writes, "they may be more susceptible to the development of stress-related disease."
There's a sort of vicious circle at work here, because many people deal with stress by, you guessed it, eating more. Dr. Valerie Taylor, psychiatrist-in-chief at Women's College Hospital in Toronto, talks about the "obesity-mental illness dyad," even suggesting a chemical association between being fat and being depressed.
"The most common biological perturbation associated with depression is an increase in cortisol," she writes in an article in the Canadian Journal of Psychiatry. She goes on to explain that high cortisol levels tend to make the body store up fat. Taylor suggests that "a type of MDD (major depressive disorder) characterized by an increase in the need for sleep and food, may actually characterize the most typical presentation of MDD."
Most people who are overweight or obese already know it; but if there's any doubt, the body mass indicator (BMI) calculator at goo.gl/vc295 may be helpful. There's even a BMI smartphone app at that site, so you can go around being obnoxiously health conscious at the office. Of course, it might be more fun to bring a tape measure to assess your colleagues' waist-to-hip ratio. There's a guide for doing that at www.healthcalculators.org and some say it's a better metric than BMI.
BMI is definitely misleading for certain body types, such as athletes with a high percentage of lean body mass. They're liable to be pegged as overweight despite being in great shape. The waist-to-hip ratio helps to sort out if you are pear shaped, with fat around the hips, or apple shaped, storing fat in the belly. Apple-shaped people generally face more health risks.
Rather than just leave you despairing about your apple shaped body or over 25 BMI, I'd like to share some of the wisdom of Dr. Michael Mosley. He's a U.K. medical doctor who, for more than two decades, has made science and medical documentaries for the BBC, often using his own body for demonstration purposes. Mosley is disarmingly candid, revealing, for example that an MRI scan showed he is a TOFI — Thin on the Outside and Fat Inside.
He laments that he has "the most dangerous sort of fat, visceral fat . . . it wraps itself around your internal organs and puts you at risk of heart disease and diabetes."
Mosley and co-author Mimi Spencer recently released a book called The Fast Diet, available in hardcover or as an ebook at books.simonandschuster.ca. The title is a tad ironic, because this diet is anything but speedy — it's actually a lifelong eating plan. The fast part refers to the fact that you abstain from eating on two non-consecutive days each week.
Mosley does a great job of explaining the science behind Intermittent Fasting and its benefits on insulin levels, genetics, even the brain, which he wryly quotes Woody Allen as saying, "is my second favourite organ."
There's a real guy feel to this diet because it doesn't involve calorie charts or diet foods or even jumping on the scale for that matter. Mosley says many men enjoy the challenge of keeping away from food for two days a week. Best of all, you can eat and drink what you darn well please on the other five days, though he suggests your tastes may change towards healthier food even on the eating days.
One obvious objection is that you'll just gorge yourself on those days, but Mosley says that's not what happens. He quotes researcher Krista Varaday of the University of Chicago. "I thought when I started running these trials," she says, "that people would eat 175 per cent the next day; they'd just fully compensate and wouldn't lose any weight. But most people eat around 110 per cent, just slightly over what they usually eat."
Mosley doesn't actually eat zilch on his fast days — he limits himself to two very light meals totalling no more than 600 calories.
"In the evening I have a bit of meat or fish and piles of steamed vegetables," he writes, "and having abstained since breakfast I find them particularly delicious."
On the other five days, he implies, it's fine to fire up the barbecue and crack a beer or two.
Dr. Tom Keenan is an award winning journalist, public speaker, and professor in the Faculty of Environmental Design at the University of Calgary.

subset: commoncrawl


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At this year's Australian Open, though, players were once more dropping like flies, denting the draws and leaving the physiotherapists at Melbourne Park severely overworked.
The nine first-round retirements, eight men and one woman, equalled the record for the most retirements or walkovers in a grand slam event.
Many of them, including the withdrawal of Palona Hercog of Slovenia after just one game, were clearly a result of a pre-existing injury.
Others, like Czech Radek Stepanek, suffered an injury early in the match and were unable to finish.
The WTA Tour ends in late October, giving the leading women nine weeks off, while the ATP Tour has a seven-week break after the conclusion of the ATP World Tour Finals in London in early November.
The spate of retirements in Melbourne have led some to question whether players are not taking advantage of the longer break to rest their bodies but instead over-training in the off-season.
It may not be as simple as that.
Andy Murray, who famously uses the off-season to train hard in Miami, said there could be any number of reasons for a high number of injuries at this time of year.
"There's a big difference between someone having a muscular injury and twisting your ankle," the Wimbledon champion said.
"Twisting your ankle is bad luck. If there's a lot of muscular sort of injuries and stuff, then that's something different. That can be down to either not training hard enough or training too much.
"Sometimes, if you've been in Europe for a long time and it's freezing cold, coming to this heat, guys can get exhausted pretty quickly, muscles get tired faster.
"When your muscles get tired, it puts pressure on other parts of your body."
The injuries continued into the second week in Melbourne as Serena Williams and Maria Sharapova both suffered problems as their title chances bit the dust.
Williams' coach, Patrick Mouratoglou, said he thought it was most likely down to the difference between practice and competition.
"All the players, you can ask them, if they practice for four hours, every day, for two months, then the first match they play, they're going to be so sore, because competition is completely different," he said.
"They push themselves much more. Even though they feel they push themselves 100 percent in practice, that's not true.
"Stress plays a very important role in that. Because of the stress they also sometimes hit the ball in extreme positions, which can lead to injuries."
Murray, who did not play between September and late December after back surgery, agreed.
"We push ourselves hard in training and in practice, but playing matches, you always will tend to push yourself that little bit harder," he said.
"No matter how much training you've done, you might have been training for four weeks in December, you can wake up after playing the first match and feel terrible just because you're going that few percent harder."
For the past few years, Mouratoglou has taken his players to a training camp in Mauritius in December.
The last month of the year is one of the few opportunities players have to work on technical changes to their game, which Mouratoglou said can be a problem in itself.
"Every technical change, especially if you repeat it every day, can also bring an injury," he said.
"If you're not used to working on a physical aspect, because during the year you cannot, and then suddenly you focus on it too much, then you can also have an injury.
"There are 100 reasons to have an injury because you have a pre-season and you're away from competition.
"The off-season is the time to improve physical things but you also have to do it in a clever way, always step by step, always giving enough recovery."
(Reporting by Nick Mulvenney; Editing by John O'Brien)


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Local Search Marketing Solutions for Small & Medium Businesses
Tired of getting passed around from manager to manager at a medium to large online marketing agency? We don't blame you!
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Walnut Cove police chief running for town commissioner
Commissioners voted to disband apartment Aug. 1
Walnut Cove's Police Chief Chad Williams has filed for election as Walnut Cove Town Commissioner. Williams became police chief in 2012, after serving as lieutenant and acting chief after the resignation of the former police chief. He is 34 years old.
Williams is a native of Walnut Cove and was hired as a patrol officer in 1999, was promoted to sergeant in 2006 and named as lieutenant in 2011. He was Walnut Cove's first field training officer and the town's first general instructor.
The Walnut Cove Police Department will no longer exist after August 1 after the Walnut Cove Commissioners voted to disband the department and sign a contract for police services with the Stokes County Sheriff's Office.
Mayor Lynn Lewis has filed for re-election as mayor of Walnut Cove.
Williams and Lewis are the only candidates who have filed as of July 9.


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|Ellicott City, Md.
|High School:
|Mt. Hebron
2014 Outdoor: Competed in the 3,000m steeplechase at the Colonial Relays at William and Mary, finishing the run with a time of 13:06.05… The time ranks as the seventh-best in UMBC program history.
2013-14 Indoor: Ran the 3,000m event three times during the winter season, posting a top time of 10:48.81 at the Rider/Lafayette Winter Games where she finished eighth… Competed in the 5,000m event at the Terrapin Invitational, clocking a time of 19:56.84.
Background: Named to the All-County Second Team for cross country in 2010 and 2011… Earned the Coaches' Award in XC in 2010… Placed 15th at the state meet in 2010 and 16th in 2011… Helped lead Mount Hebron to a second place finish at the state championships in 2010.
Personal: Daughter of Robert and Pamela Vane… Has two sisters, Paige and Lauren, and one brother, Phillip… Plans to study engineering and mathematics… Born Dec. 26, 1994.


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Edinburgh PAT Testing
The Health and Safety Executive in the UK, and legislation such as the Electricity at Work Regulations, state that electrical appliances should be maintained to ensure that they are safe and pose no risk of injury to the persons using them. The only real way to comply with the various pieces of legislation is known as PAT testing and in Edinburgh it is an important part of any health and safety policy within the workplace.
With over twenty five percent of reported accidents involving electrical equipment, statistics show that in situations where PAT Testing does not take place in Edinburgh, electrical equipment has failed to be correctly maintained. Additionally, incidents of fire frequently start by electrical appliances either not being kept in good condition or by equipment being used for purposes other than intended or by being stored in unsuitable conditions.
The level to which the equipment has to be tested depends on the type of appliance, the nature and location in which it is used and the likelihood of it becoming faulty. The Health and Safety at Work Act places a legal obligation on employers and the self employed in situations where electrical appliances are used by employees in the workplace. This also applies to such places where repairs or services of equipment are carried out, or by the public for example, in shops, hotels, schools, medical centres, and rental shops with equipment for hire.
If you fall into any of the above mentioned categories or one similar, then you need to ensure your portable electric appliances have their PAT testing done in Edinburgh.


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Managed Commodity Accounts
In a managed commodity account, you're essentially transferring the responsibility of making all buying and selling decisions to a trained professional instead of making those choices yourself.
Open a managed account in these cases:
You don't follow the markets on a regular (that is, daily) basis but are interested in getting exposure to commodities.
You follow the markets regularly but are unsure about which trading strategy will maximize your returns.
You don't have the time to manage a personal account.
You feel comfortable knowing that someone else is making trading decisions for you.
If these statements apply to you, you're ready to open a managed account. So how do you get started? First, you need to determine your investment goals, time horizon, and risk tolerance. Then you need to find out about any minimum capital requirements, commissions, or management fees you may face. When you have this information, you can move on to choosing a commodity trading advisor (CTA) to manage the account.
If you have mutual funds, the CTA is similar to a fund manager. The FCM, on the other hand, is more like a stock brokerage house. The FCM provides you with a trading platform, whereas the CTA actually manages your accounts for you.
A CTA is a securities professional who is licensed by the National Association of Securities Dealers (NASD) and the National Futures Association (NFA) to offer advice on commodities and to accept compensation for investment and management services. Before you select a CTA, perform a rigorous background check.
Because a CTA is required to register with the NFA to transact with the public, you can find out a lot about a CTA by simply visiting the NFA website.
You want to find out this info about your CTA:
How many years of market experience does he have?
What is his long-term performance record?
What is his trading strategy, and does it square with your investment goals?
Does he have any complaints filed against him? (This information is publicly available through the NFA.)
Many CTAs manage more than one account. Try to find out how many accounts he's currently managing. If the number seems too high (more than 100), maybe your account won't be a high priority for him.
Does he have a criminal record? If so, find out the details of any arrests or convictions he has. This information is also available through the NFA.
If you perform due diligence on your CTA and feel comfortable with him, you're ready to turn over trading privileges to him. How do you do that? You have to sign a power of attorney document.
After you sign that document, your CTA gets full trading discretion and complete control over the buying and selling of commodities in your account. He then makes all the decisions, and you have to live with the good (and sometimes bad) decisions he makes.
If you trade stocks, this account is similar to having a discretionary individual stock account, in which your stockbroker makes trading decisions for you. The main benefit of the managed account is that you get a trained professional managing your investments. The drawback is that you can't blame anyone but yourself if you incur any losses.
A CTA is allowed by law to manage more than one account and have more than one client. However, a CTA must keep all managed accounts separate. Thus, there's no commingling of funds allowed and no transferring profits or losses between accounts. When you choose a managed account, make sure you get a CTA who will manage your account based on your personal risk profile.


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Casa Kids designs, manufactures and sells modern kids bunk beds, loft beds, chairs, desks, storage units. We specialize in custom kids rooms and furniture.
Casa Kids | 106 Ferris Street, Brooklyn, NY 11231, Kings


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Adrian making major impact on LA Latino community
LOS ANGELES -- The home runs and RBIs are archived for all to see, but many of Adrian Gonzalez's contributions, if less visible, are arguably even more important.
Gonzalez is not only in the middle of the Dodgers' batting order, in little more than a year, he's become an impact player in the franchise's community outreach, especially as it impacts fellow Latinos, which make up roughly half of the City of Los Angeles' four million residents.
LOS ANGELES -- The home runs and RBIs are archived for all to see, but many of Adrian Gonzalez's contributions, if less visible, are arguably even more important.
Gonzalez is not only in the middle of the Dodgers' batting order, in little more than a year, he's become an impact player in the franchise's community outreach, especially as it impacts fellow Latinos, which make up roughly half of the City of Los Angeles' four million residents.
"In the little over a year that Adrian has been in Los Angeles, his impact has already been felt on the civic, cultural and sports front," said Renata Simril, the club's senior vice president of external affairs. "Adrian's outlook on this civic responsibility has endeared him to a fan base that's been looking for someone who shares a similar life story and cultural upbringing. That is why the Latino community of Los Angeles loves him."
Much of Gonzalez's charity work benefits PADRES Contra El Cancer, an organization committed to improving the quality of life for Latino children with cancer and their families. The organization promotes a comprehensive understanding of childhood cancer and other blood disorders, as well as effective methods for treatment.
Honoring the commitment he made in Boston, Gonzalez made a significant performance-based monetary contribution to PADRES at the end of last season. In 2013, he invited families served by PADRES to the Dodgers game on Mother's Day. The families were treated to parking and tickets in the all-you-can-eat section so that meals were provided for all invited. This invitation was the first date of a season-long program Gonzalez initiated, "Adrian Gonzalez's Viva Los Dodgers Days."
Gonzalez, the Dodgers' nominee for the 2013 Roberto Clemente Award, was an honorary Co-chair for the PADRES Contra El Cancer "Stand for Hope Run/Walk" that took place in June in Los Angeles. He was on the road with the team, but supported it through social media efforts, recorded a public service announcement, lent his image to the marketing campaign and donated tickets to a game, parking and a meet-and-greet with him for the top fundraiser of the walk to incentivize the participants.
While in San Diego, and continuing in Boston during his time with the Red Sox, Gonzalez formed the Adrian Gonzalez Scholarship, a program providing financial assistance to underprivileged students attending four-year colleges and universities. Scholarships are granted to students from low- to middle-income families with strong academic records who are involved in a balance of community, school and work activities with a focus on community service.
Adrian and his wife, Betsy, financially support two baseball fields in Tijuana, Mexico, for youth -- "Campo Adrian Gonzalez en la Liga Municipal de Tijuana." He attended rededication ceremonies for both fields last November and donated Dodgers items to the youth baseball players.
The couple also host families at each Sunday home game for his "Viva Los Dodgers Days," which started on Mother's Day. The program provides all-inclusive all-you-can-eat tickets and parking for families in greater Los Angeles by partnering with various nonprofit organizations that provide various services to the underprivileged and low-income communities.
Last winter, Gonzalez was a non-stop outreach machine. In December, he hosted the annual Dodgers Children's Holiday Party at which 300 local youth were invited to read with Santa, play games with current Dodgers and Dodgers alumni, eat lunch and receive Dodgers goodie bags.
Also in December, Adrian and Betsy purchased and donated $25,000 in toys that they helped to distribute to children in East Los Angeles at a children's holiday celebration. They have stated that they will do this annually for a deserving charity.
In January 2013, Adrian, along with many other teammates, made a special trip to Los Angeles to take part in the annual "Pitching in the Community" Caravan, a full day of community service.


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Harijans (hâr´Ĭjănz´) [children of God], in India, individuals who are at the bottom of or outside the Hindu caste system. They were traditionally sweepers, washers of clothes, leatherworkers, and those whose occupation it was to kill animals. The term is also sometimes applied to the hill tribes of India, who are considered unclean by some because they eat beef. Originally called untouchables or pariahs, they were given the name Harijans by the Indian political and religious leader Mahatma Gandhi, who worked for many years to improve their lives. Many now refer to themselves as Dalits [Marathi,=broken] to indicate their oppressed position outside Hindu society; legally the Indian government groups them as
"scheduled castes."
Until the Indian constitution of 1949, Harijans, who constitute 15% to 20% of India's population, were subject to discrimination and social restrictions because of their "polluting" effect on those with whom they came into contact. Under the constitution, the Harijans were recognized as scheduled castes and tribes entitled to educational and vocational opportunities, as well as representation in parliament; however, widespread discrimination still exists.
Some Harijan leaders have become powerful in Indian politics. Jagjivan Ram, one of the first of his caste to receive a formal education, held several cabinet posts under Indira Gandhi and was a leader of the Janata coalition that unseated her in 1977. K. R. Narayanan was a government minister and served as India's president (1997–2002), and Meira Kumar was the first woman to be elected (2009) speaker of the Lok Sabha, India's lower house of parliament. Others have obtained a strong voice in state politics, particularly in Maharashtra and Uttar Pradesh. Militant untouchables formed the Dalit Panthers in Mumbai, while many have sought to escape the stigma of their birth by conversion to Buddhism, Christianity, or Islam.
See B. R. Ambedkar, The Untouchables (1948); J. M. Mahar, The Untouchables in Contemporary India (1972); D. Hiro, The Untouchables of India (1982).


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God Is Over All
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Christmas Fest Dec 2017
Praise Til you Drop Worship Service July 21, 2017
Testimony Tuesday Serviceon July 11th, 2017
Fathers Day Group Picture
Sunday NIght Live March 2017
MLK Jr Brunch Jan 2017
WHIP Christmas Tea & Crumpets Party, Dec 2016
Christmas Fest Dec 2016 pt.1
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Youth Outreach Porch Praise, Dec 2016
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CMI Present a published report on "Global Dry Shampoo Market Industry Analysis, Growth and Forecast 2019 – 2026" delivering key insights and providing a competitive advantage to clients through a detailed report. The Dry Shampoo Market is the foundation of the improvement edges and prospects, as the progression of an explicit plan needs various imaginatively maintained theory, musings, and methodologies. The report contains exhibit on current market analysis scenario, upcoming as well as future opportunities, revenue growth, pricing and profitability.
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Our mission is to provide each Webelos Scout and leader a most positive first Boy Scout camping experience!
Gear and Meals: Bring your own camping gear and tent as well as a sack dinner for Friday night. All meals on Saturday and breakfast on Sunday will be provided by our staff. Please note on the registration if there are any allergies. We highly recommend that if you or a boy has an allergy to nuts/peanuts that you provide your own food. We can not guarantee that the cooking equipment that we use is free of nuts or peanut oil.
Activities: While the boys are off learning Scout skills by trained Boy Scouts, the adults will be attending Webelos Outdoor Training. The adults and boys will be together only for meals and in the evenings.
Boy Scout Staff
Boy Scouts and Leaders: Are you interested in running a station? Are you interested in being a Patrol Leader? We're putting together the most enthusiastic, energetic, and terrific staff Webelos Weekend has ever seen! Join us and help carry on a 37 year tradition of giving Denver Area Webelos Scouts the best camping experience they've ever had.
Staff meeting are being held every third Thursday at Faith Christian Academy (4890 Carr Street Arvada - I-70 Frontage Road and Carr) from 7pm-8pm starting March 20, 2014. Come meet the rest of the team, get valuable information and learn skills to help lead the Webelos, their Parents, and Adult Leaders.
It is highly recommend that you download and print the Leader's Guide. It includes the health form that is a mandatory item for each Scout and adult.
Cost for Webelos Weekend as a staff member is $27.00.


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S k a t e L o g F o r u m
Inline Skating and Quad Roller Skating
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|Quad Vert All kinds of aggressive skating on quad roller skates including quad vertical roller skating, quad bowl skating, quad skatepark tricks, and street skating tricks in quad skates.
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|February 23rd, 2012, 02:04 PM
Join Date: Jan 2012
Location: Charlotte, NC
Posts: 68
How do you learn to grind?
There are no other quad skaters at the park I go to and very few inliners either, so I am reduced to Youtube and message boards to try to get this sorted out. I am also the only adult female I have seen on wheels at this skate park, and the only adult who is trying to learn (there are quite a few grown men, but they have been skateboarding for years) which puts me even farther out of the mainstream. But I really want to learn to do this!
They only have coping at this particular park on the really steep areas. The less intense slopes, you just roll over. And this makes it hard to learn on the coping. They have some box thingys with coping on the edges, but they are on top of bumps and slopes, so again, it is hard to learn.
Looking at Youtube, the way to learn and practice is a grind bar or box in the driveway. Which is easier to learn on? I saw one vid with a kid grinding on a heavy waxed up fence post. I could go get one of those at Lowes for like $20. My husband is handy, so it would be easy to make a box. I see many designs for free in the interwebs. We can say it is for the kids I saw bars for sale online, which would be easier than making one since we don't have welding tools.
And what is this skate wax? I can get it at the local skate shop I guess. But I feel embarrassed to ask too much.
So I am looking for easy to learn on/cheap/easy to make in pretty much that order.
|February 23rd, 2012, 09:30 PM
Senior Member
Join Date: Oct 2007
Posts: 2,026
I find that a wooden half pipe is the best place to learn, with metal pipe coping. As long as it is about 4 to 6 feet tall, it makes falling more like sliding down. Not so hard on the body. Also, you can carve into the grind more as you progress to slide farther and farther.
Factory Rider for Pro'Designed Inc.
..................Biff Riley.................
|August 23rd, 2013, 05:48 PM
Junior Member
Join Date: Aug 2013
Location: USA
Posts: 5
I am posting this a bit late but hopefully, someone else will benefit from it if you already mastered your goal of grinding.
Grinding is a bit difficult but since you mention you are on quads, you can start by just jumping lines cracks on the ground.
Start by jumping while standing still on skates to find balance
Move on to skating slowly while jumping a single crack- move up to several cracks or lines on the road in a row while skating (moving) it sounds like a task you can do in about 5 seconds but it takes more energy and focus then people realize. Eventually you notice you go from barley lifting your feet, to three inches, eventually 6 inches and when you feel ready, you can try to incorporate moving the hips towards, say a curb to start with and work your way up to this structure your husband built.
Also, I know it feels weird going to skate shops but at the end of the day, they are there to sell things to people. If you feel really super embarrassed just go to an online skate shop, email them and buy through them- or just do not go to the local skate shop you typically go to and go to the next closest one.
Good luck!!
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A Monroe County Sheriff's Office deputy was arrested after he was caught buying fake Oxycodone pills in an undercover operation Saturday night, authorities said.
Deputy Jaime Miranda, 30, is facing charges of conspiracy to purchase narcotics, possession of synthetic narcotics, possession of a controlled substance without a prescription and possession of drug paraphernalia, the MCSO said.
He was booked into jail and it is unknown whether he has an attorney.
Tornado Touches Down in Florida Keys
According to the MCSO, Miranda was on duty and in his marked patrol car at the Winn Dixie shopping center on Big Pine Key when the transaction took place.
Detectives had arranged for an undercover operative to meet Miranda and sell him the 10 fake pills. Miranda accepted the pills and agreed to pay the operative on Monday, the MCSO said.
After the transaction took place, a detective searched Miranda's patrol car and found nine and one quarter of the fake pills, as well as 12 Hydromorphone pills in the glove compartment, the MCSO said.
Man Killed After Boat Capsizes Off Miami Beach
The detective also found a pipe with marijuana residue in it inside Miranda's pocket, authorities said.
Miranda admitted to taking part of one of the fake pills just after the transaction, and admitted to taking the Hydromorphone pills from his aunt's home without her permission, authorities said.
Miranda, who was hired by the Sheriff's Office in 2008 and has been working as a road patrol deputy in the Lower Keys district, has been suspended without pay.
"The integrity, honesty and professionalism of the Monroe County Sheriff's Office is crucial to our ability to perform the job of law enforcement. I will not tolerate any behavior that compromises these values," Sheriff Rick Ramsay said in a statement. "I am proud of the detectives who investigated this case. They did the right thing under difficult circumstances."
More Local Stories:


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Reggie Martin
Lives and works in South L.A.
Reggie Martin is a professional artist with special needs who has been working out of ECF Art Centers' South L.A. studio. He is represented by DAC Gallery, where he regularly exhibits. ECF Art Centers is an adult program of the Exceptional Children's Foundation, a Los Angeles-based nonprofit organization that provides services to adults and children with developmental disabilities.


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(click to listen)
Hosted by AAA President Virginia R. Dominguez, "Inside the President's Studio" features interviews with anthropologists about their ideas, research and passions. It is part of an ongoing effort to foster public, visible and active engagement with anthropologists. Become a part of the conversation by reading and listening to the interviews, adding your comments to the blog, and suggesting people or topics for future pieces.
This month's guest is medical anthropologist and past SMA president Carolyn Sargent. She discusses her efforts to bring the expertise of medical anthropologists to the national health care debate and a recent meeting she had with Rep. Russ Carnahan (D-MO) on the issue. Listeners will also learn about Carolyn's love for piano and detective fiction, her training in anthropology under Max Gluckman, her Peace Corps experience, academic life, and a number of other topics.
Carolyn's written responses are copied below:
(1)What are you passionate about?
My lifelong passions are piano, detective fiction (female PI's), and medicine–
(2) How long has this been a passion?
I have a photo of myself playing the piano at age 2, mysteries captured me as an adolescent, and medicine intrigued me in different ways at different ages (plagues and epidemics, tales of epidemiological detection as an adolescent, colonial medicine in college, maternal and child health in the Peace Corps).
(3) Do you remember how and when it first became a passion of yours?
My academic engagement with health and medical systems really took shape in the Peace Corps, when (although I was officially part of an animal traction project to train draft animals) I spent a lot of time at the provincial maternity clinic, hanging out with the government midwives. Their clients were primarily elite women, wives of government officials or wealthy traders. I had what I thought was a bright idea of doing neighborhood outreach, weighing babies around town. The midwives were totally opposed. This and two years worth of observations at the clinics culminated in my graduate school research on reproductive health. Over the years, my interests have expanded to include bioethics (ten years on two hospital ethics committees), immigrant health, and the national health debate in the U.S. I have a deeply personal engagement with the health insurance debate because I have a daughter with chronic health issues who has been an aspiring actor (now in graduate school, still having a hard time with health insurance!)
(4) What makes you mad?
(5) What makes you smile?
Dogs (especially my bichon Quasimodo who had an eating disorder, he ate walls, furniture, doorstops, earphones…)
(6) If you were Secretary General of the UN or President of the U.S. or Surgeon General of the U.S. or head of the World Health Organization, what would you especially want to achieve (or at least work on)? Or… might such a position not appeal to you at all?
I have no desire to be President of the US or Secretary General of the UN. Head of WHO, on the other hand….I'd like to have the authority to prioritize integrated health projects, relying on interdisciplinary teams, including local representation, and taking a broad perspective on a particular health issue (e.g. environmental, preventive, curative). I think of this because I recently listened to a report at our medical school (Wash U) by a physician who has received a multi-million $ grant to eradicate microfilarial diseases in West and Central Africa. The plan focuses only on medication, and the team is not interested at all in crumbling dams that lead to mosquito breeding sites, other mosquito-borne diseases that won't respond to this medication, sleeping nets, local understandings of these diseases…. This is a huge and ambitious project in terms of financing and countries involved but regrettably narrow in scope. Now if I were in charge…..
(7) You have recently stepped down as President of the Society for Medical Anthropology. Have you, in fact, ever thought of quitting the academy and running for public office? If so, which office might actually appeal to you and why?
I have zero desire to run for public office. I am sure that I would hate campaigning and would be in a state of constant disappointment at having to compromise a great deal on positions of principle that matter a lot to me. On the other hand, participating on the SMA Health Task Force that I started as SMA president /is /an enterprise that I really value. I hope that we can interest medical anthropologists as well as anthropologists from all fields, academic and practicing, to join our initiative. We're currently exploring the feasibility of creating an infrastructure via which anthropologists could provide (collect, if necessary) data to policymakers in response to requests for information; another idea is to compile digests or abstracts of existing research to make these studies more accessible to legislators, among others.
(8) Is there a particular version of health care reform in the U.S. that you especially champion, and is it based on existing practices in some other country or region, or is it mostly an unrealized goal worth pursuing somewhere on our planet?
I champion a single-payer health care system for the U.S. similar to that in countries I have lived in (France, U.K.) where I have been a consumer of medical care. Every system has its flaws but I have been very impressed by the underlying values of the French system (the constitution guarantees the right to health care) and the extent to which social class is so much less a factor in access to care than in the U.S. Undocumented migrants have much less difficulty obtaining health care; women and children have extensive coverage. Also, health outcomes are among the best in the world. During ten years of research in France, I've been a "patient" several times, including once in an emergency. The costs were extremely reasonable and the care I received was excellent. And my French friends aren't living in a panic about their children's access to health care.
(9) What is something that only your closest friends and loved ones know about you?
Do I have to answer this? Too embarrassing.
(10) What did you think you'd be doing in your 40-50s when you were 17? Does it make you smile to remember that? Sad? Inspired? Amused?
When I was 17, I can't recall even imagining life at such an age–totally ancient. Looking back, I envision several of my great aunts, with arthritic fingers, playing bridge. I think I assumed, insofar as it crossed my mind, that eventually I would morph into such a person. Now it's quite obvious that I'm never going to be a bridge player, I don't have bejeweled fingers, & refuse to have blue hair.One of my best friends is 98 and in a study of the "old old" with remarkable cognitive capacities. She's my vision of the over 50 set now!
(11) Do you ever feel like giving up and just accepting the status quo? Have you come close to doing so in the past?
Yes, I feel like giving up and accepting the status quo periodically. So far, though, I eventually get mad enough to keep arguing.
(12) You and I worked together on the Eileen Basker Memorial Award Selection Committee over the past few years. What surprised you the most about that work? The books we read and considered for the prize? the level of agreement among selection committee members? the range of topics? absent books or topics? difficulties you experienced judging evidence of vision and courage? perhaps how easy you find it to determine those?
Working with the Basker Prize committee has been truly rewarding. We have the opportunity to read new and exciting works on topics that most interest me, and often most of us agree on the award recipient.I'm not sure we always consider courage as a factor in our selection, but "evidence of vision" is a priority and there, I'm impressed with how often we find this exemplified in the nominated works. For me, this committee has not been a chore, or controversial, but an opportunity to expand my thinking about research on gender & health.
(13) You recently moved from SMU to Washington University in St. Louis. Has the move been eye-opening in some way? If so, how?
Moving from SMU to Washington University in St. Louis has been more than eye-opening. My department at SMU is excellent but not well supported by the larger institution. I now find myself in a department with 32 faculty and an extraordinary student population. The undergraduates alone are spectacular (it was eye-opening to be told by a first-year student in my class that he thought we had an epistemological dilemma…) We have almost 300 majors and anthropology is a highly valued discipline and department on campus. We now have seven medical anthropologists, which is a great pleasure for me. AND in spite of the doubts of my friends who suspected St. Louis would be a dreary town (:what????you're leaving DALLAS for St. LOUIS??) it is actually a culturally dynamic, architecturally intriguing, ethnically diverse city with great restaurants and a fabulous park. Plus I can walk to work!
Past Interviews:


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Crytek, the studio behind the Crysis series and its eye-bleeding Cryengine graphics tech, are getting ready to launch their newest game. It's a free-to-play shooter. It's already out in some parts of the world and it's called Warface.
Yes. That is the name. "Warface".
Crytek would very much like you to take this game seriously. They have created a gaggle of dramatic promotional images like the one above, mostly of frowning men with guns. These men have a Job To Do. That job is written all over their faces. The writing looks... like war.
Crytek is attempting to take Warface and free-to-play seriously, according to a new article over at Polygon. That isn't going to happen. When I see "taking seriously" in the same sentence as "Warface", I don't take it seriously at all.
This isn't to say that dumb names can't catch on. After all, we're already tossing around "Wii U" like it's a perfectly normal, not-at-all ridiculous name. But it's been ages since Crytek's game was announced, and Warface sounds just as clunky and silly as ever.
"What are you going to do after school today, man?"
"Oh, you know. Go home. Have a Hot Pocket. Play some Warface."
It sounds for all the world like a playground insult:
Billy: "You're a big stinky-pants!"
Bobby: "Yeah, well you're a WARFACE!" [Starts crying]
I like Crytek's games. Warface might even be fun, in a meat-and-potatoes shooter kind of way. But I swear, as long as it continues sporting that ridiculous name, a huge subset of people, including me, are never going to take it seriously.
Crytek taking free-to-play seriously with 'Warface' [Polygon]


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MissionEasthampton Youth Soccer Association's mission is to organize and provide an environment for the children of Easthampton to learn and play soccer at both a recreational and competitive level. The focus of the soccer association's programs is to develop children's soccer skills and educate them in the rules and strategies of soccer in a fun atmosphere. Coaches and parents are encouraged to work together to foster a love of soccer while developing a strong sense of teamwork, sportsmanship, respect and community.
Volunteer!EYSA is completely run by volunteers and there is always some way to help out. Read through our list of Volunteer Opportunities and Contact us to get involved!
Find Us On Facebook!


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Books, Movies, Music
JCPL Catalog
Reading programs and Book Groups
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Kids Zone
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For Parents and Teachers
Student Portal
Main Content
Children's Book Week May 7-13
Teachers, librarians, parents, publishers - they're all focused on you this week! Children's Book Week is the time to celebrate the amazing choices you have at the library and bookstore. From comics to mysteries, from magic to history...you can find anything between the pages of a book!
Ideas for Celebrating Children's Book Week
- Make your voice heard with the Children's Choice Book Awards! Voting is open now! Children's Choice Book Awards are given to the winner in each age group at a gala ceremony in New York during Children's Book Week. Check out the 2012 finalists and vote!
- It doesn't need to be Book Week for you to find great books: the Children's Choices list is available all year round. Kids across the country pick their favorite books each year, and about 100 books make the cut. You can find the lists from other years here - come find out what other kids think are the best books of the past few years!
- Come test your skills with these Children's Book Week puzzles!
- Great authors have started a story... come help them finish the tale with Story Starters!
- Download the official Children's Book Week bookmark, or make your own charmed bookmark. Better yet, do both!
- Draw a picture from your favorite book, put your first name and age on it and send it to us in person, or by email, and we will post it here for everyone to see!
- Come to one or all of the library's events for Children's Book Week!


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MARIETTA, Ga. - The Georgia Roadrunners 15U showed up to play on Day 2 of the 2013 15U WWBA National Championship, shutting out the St. Louis Gamers 15U Gray, 13-0, and increasing their record to 3-0. When you thought the headline would be the offense, it was the pitching that stole the spotlight.
Sawyer Steele tossed the game of his life, throwing his first ever no-hitter on just 61 pitches. Steele went six innings and allowed just two walks, while striking out seven. He stayed around the plate the entire game, throwing first-pitch strikes to 16 of the 19 batters he faced and hitting the strike zone on over 75 percent of his pitches.
"It's like working a video game with him pitching today and hitting his spots," said Roadrunners pitching coach Bob Howard.
"The pitching's been fantastic and I hope we can keep it up."
One of Sawyer's teammates and a member of the rotation watched the performance from behind home plate, taking notes for his team. He was impressed with what he saw out of Steele.
"Being a fellow PO (pitcher only), I'm really proud of the way Sawyer pitched; hitting his spots, changing speed, and keeping the hitters off balance."
"We hooked our pitcher up today. We fought for him," said second baseman Cobie Vance. "We were working in the field. We just took advantage and made the plays."
Vance and shortstop Jahmai Jones made some tough plays to preserve the no-hitter, including a 6-4-3 double play.
"(We) just went out there and played defense behind him and there's not much more to be said," Jones commented. "He pitched a great game."
Steele kept it simple, saying, "It was good. I just went out there and threw."
He got more than enough run support to back him up for the win. The Roadrunners scored 13 runs on 15 hits, 7 walks, and a hit batter. The lineup hit from top to bottom. There was not really any standout player on offense.
The Roadrunners collected five doubles, some of which looked like they were going to leave the ballpark.
Kevin Strohschein collected two singles and an RBI and is 4-for-5 in the tournament. Michael Curry hit his second double of the tournament, batting in the cleanup spot.
Curry is the No. 84 ranked prospect in the class of 2015 and Junior National Showcase attendee who tied for the third best pop time (1.87 seconds) and had the second best catcher velocity (82 mph).
Curry isn't the only standout players on this loaded Roadrunners squad. The team excels throughout the lineup and on the mound.
In their three tournament games so far, the Roadrunners have outscored their opponents 26-0. They have tallied 25 base hits, including 11 extra-base hits and have walked 16 times.
No strangers to the WWBA National Championship, the Roadrunners project to be one of the better teams in the tournament this week.
The Roadrunners have four games remaining in pool play and will play the Frederick Rangers at 1130am today at Pinecrest Academy.


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The City Strategy for tackling unemployment and child poverty (United Kingdom)
The City Strategy aims to improve support to the jobless, in the most disadvantaged communities across the UK, through a bottom-up approach that devolves more decision and funding powers to the local level.
Host Country : United Kingdom
Place and date : 6. - 7.7.2009
Peer countries : Austria - Bulgaria - Czech Republic - France - Greece - Latvia - Lithuania - Norway - Portugal - Serbia
Stakeholders : ESN, Eurocities
The idea is to test how best to combine the work of government agencies, local government agencies, the private sector and voluntary associations in a concerted partnership and to test whether local stakeholders can deliver more by combining their efforts behind shared priorities alongside more freedom to innovate. The aim is to provide the support jobless people need to find and progress in work by ensuring that local employment and skills provision services are tailored to the needs of both local employers and residents. The host country hopes that it will contribute to the UK Government's long-term aims of increasing the number of people in work and tackling child poverty.
Pilot projects have been launched in 15 `Pathfinder' areas (mainly major cities and other urban areas, where employment levels are furthest from the UK's 80% target) and Ministers have agreed to continue the Department for Work and Pensions' (DWP) support for all Pathfinders until March 2011.
All Pathfinders agreed to set themselves standard targets in terms of reducing the number of people on out-of-work benefits and increasing the local employment rate. Also where areas have a significant ethnic minority population DWP also agreed an additional local target on reducing the numbers of ethnic minorities out of work.
Initial appraisal of the programme, which has been allocated £65m (around EUR 70-75m) in government funding from 2007 to 2009, has found that it acts as a catalyst in enhancing coordination between local activities and national policy, increasing the priority give to reducing unemployment, including increasing local resource both financially and in terms of staff capacity, and making those involved feel more accountable for achieving targets.
Peer Review manager
Ms Katja Korolkova (ÖSB Consulting GmbH)


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Ariana Grande's Big Brother Joins 'Big Brother' Castby Mandi Salerno | PopCrush
The Grande family is apparently full of stars! Ariana Grande's big brother Frankie Grande is following in her spotlighted footsteps and joining the cast of 'Big Brother' for its 16th season.
You might recognize Frankie from his YouTube channel, or the few times he's walked a red carpet with his half-sis Ariana. Soon he'll be hitting your TV screen, where he'll be battling 15 other contestants to win the $500,000 prize.
The 16 housemates were introduced today (June 19) when CBS posted the cast photos. The pink-haired 31-year-old is sporting a striped button-up and a smirk for his pictorial debut. (The smirk has us wondering what his 'BB' house strategy will be.)
Ariana tweeted her congratulations to Frankie shortly after the photos were shared. It's obvious who she'll be rooting for this season!
congrats to my big brother on being cast in season 16 of big brother…… so proud of u / I'm a nervous wreck #bb16 you're gonna kill it
— Ariana Grande (@ArianaGrande) June 19, 2014
Yesterday, 'Big Brother' host Julie Chen revealed to 'The Talk' that Season 16 is going to be crazier than ever, with lots of new twists. We're dying to know what's in store for Frankie and the other housemates!
The first episode of 'Big Brother' Season 16 will air on June 25 at 8PM ET.
See Ariana Grande + More Pop Stars Without Makeup


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Men's Pink Ribbon Team T-Shirt
- Show your support in our Pink Ribbon Logo T-Shirt...Great for Liberos!
- Great for upcoming Qualifiers and any special Awareness event
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In crime laboratories, scientists analyze evidence collected from crime scenes, suspects and victims. They may analyze anything from DNA or fingerprints to human remains or suspicious substances.
Due to the increasing reliance on scientific methodologies in criminal investigations, many laboratories have faced mounting workloads. NIJ has committed to helping crime laboratories increase their capacity by streamlining their processes, hiring more personnel, purchasing technology and supplies and providing up-to-date training to keep up with technological capabilities in solving crime. NIJ also supports accessible resources for crime laboratory personnel, such as Web-based databases.


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Musician Neil Young is gearing up to announce PonoMusic, a new service aimed toward audiophiles who want the best possible sound.
Young is expected to unveil the service, alongside an iPod competitor called PonoPlayer, tomorrow at SXSW. But details have already been leaked ahead of the announcement via Computer Audiophile.
"It's about the music, real music," Young said in a press release. "We want to move digital music into the 21st century and PonoMusic does that. We couldn't be more excited — not for ourselves, but for those that are moved by what music means in their lives."
PonoMusic will offer 192kHz, 24-bit recordings with "digital-to-analog conversion technology intended to present songs as they first sound during studio recording sessions," according to Rolling Stone. The service will include songs from major labels as well as indie labels.
The PonoPlayer has 128GB of memory and can store anywhere from about 100 to 500 high-resolution digital music albums. A big complaint music junkies have about the iPod is the lack of quality audio. That's what Young hopes to solve with PonoPlayer.
When it officially launches, the PonoPlayer will cost a hefty $400. It will be available for preorder at a discount via Kickstarter starting March 12.
Check it out below.


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Phone – 888.424.3336
Email – email@example.com
701 Tecumseh Road
Clinton, Michigan 49236
Soothing, satisfying tea of gas fired cauldron roasted tea twigs and mature leaves. Aged 2 to 3 years after roasting. Lowest caffeine of Eden imported teas, 90% less than brewed coffee. Ideal at meal's end. 50% kukicha tea and 50% apple juice is an excellent beverage. Antioxidant health benefits. Quick and easy, environmentally appropriate tea bags.
Eden Organic Kukicha Tea is crafted from four different clippings of the tea bush (Camellia sinensi). The first clipping is from three year old, semi-wild plants, from which twigs from the under part of the bush are trimmed in autumn. The second clipping consists of thick twigs, which are harvested every 10 years, usually in mid-winter. During the autumn and winter the caffeine level is at its lowest. The third and forth clipping, done every year in March and June, consists of small, thin twigs, stems and mature brown dried leaves. These are the pruning that stimulate the growth of fresh green shoots. After harvesting the twigs are steamed to soften them, and then place outside to dry in the sun for about one week depending upon the weather. Next, the sun dried twigs are placed in brown paper sacks and stored for 2 to 3 years in order to fully develop the best flavor. This process is called aging. After aging, the twigs are cut, and graded according to size. The twigs are separately roasted, according to size, to ensure even roasting, in gas fired cast iron rotating ovens. This patient and ceremonious roasting slowly develops the distinctive smoky flavor and aroma that has made Kukicha Tea so popular among macrobiotic and natural food aficionados.
Also known as 'twig tea', Kukicha is the lowest in caffeine of the traditional teas. Eden Organic Kukicha Tea contains 90 percent less caffeine than regular brewed coffee. It is soothing and balancing with a rich flavor and is an ideal meal's end serving.
Most tea bags contain a plastic that allows them to be heat sealed. We didn't think this was any way to treat good tea. Every part of an Eden tea bag reflects the highest care, from its unbleached manila fibers, to its crimped seal and 100 percent cotton string. No whiteners or plastics used.
The flavor of tea reflects the soil it is grown in, the season picked, and the curing process. Eden Organic Kukicha Twig Tea is nurtured according to strict organic standards. The growers are dedicated to the stewardship of their land, water,and tea bushes. This dedication shows in their skillful traditional handling that gives us the best organic tea in the world.
All true teas stem from the plant Camellia sinensis, an attractive perennial shrub about five feet tall with gentle rounded leaves and tender twigs. Tea become green, black or other varieties depending on the time of harvest, and the way they are cured and handled.
Kukicha tea was popularized in the U.S. and Europe in the 1960s by George Ohsawa, the founder of modern macrobiotics. Mr. Ohsawa considered kukicha to be the perfect complementary beverage for a grain based or mostly vegetarian diet, due to its alkaline qualities and very low level of caffeine.
Kukicha's natural tannins aid in digestion of grains, and gives it the peculiar ability to neutralize both acids and alkalines in food we consume. Kukicha blends well with apple juice. Simply mix half kukicha and half apple juice for a perfect beverage. Kukicha is one of the most popular teas sold in natural food stores.
Eden Organic Kukicha Tea is produced in the ancient traditional manner as it has been for centuries. Eden Traditional Teas contain no added flavorings, dyes, or additives whatsoever during processing.
|Kukicha, Twig Tea, Organic
|Item Number
|Roasted Organic Tea Twigs and Leaves (Camellia Sinensis)
|Case Quantity
|Package Size
|16 bags
|Package Size Metric
|16 bags
|UPC Code Each
|UPC Code Case
|Eligible for Flat Rate Shipping
|Gluten Free
|Wheat Free
|Non GMO


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Raltegravir + Lopinavir/Ritonavir Versus Efavirenz + Tenofovir + Emtricitabine in Treatment Naive Patients
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00752856
Recruitment Status : Completed
First Posted : September 16, 2008
Last Update Posted : April 2, 2014
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
CCTG 589 is a randomized, open-label, pilot study comparing the efficacy, safety and tolerability of RAL plus LPV/r to EFV plus TDF/FTC in HIV-infected, treatment-naïve subjects. Subjects will be ineligible if they have any evidence of drug resistant virus in the past or at the time of screening (if never previously tested). Those who are found to be eligible will be randomized 1:1 to initiate either LPV/r (400/100 mg) plus RAL (400mg), both given twice-daily, or fixed dose combination of EFV (600 mg), TDF (300 mg) and FTC (200 mg) given as once-daily Atripla® for 48 weeks.
The novel nucleoside-sparing combination of LPV/r + RAL will have a faster phase 1 viral decay rate compared to standard-of-care therapy with EFV/TDF/FTC in antiretroviral-naïve patients.
- Faster phase 1 viral decay dynamics will be associated with improved longer-term (week 48) viral suppression.
- Faster phase 1 viral decay dynamics will be associated with accelerated early (Day 0-14) clearance of cell-associated HIV DNA.
- Faster phase 1 viral decay dynamics will be associated with greater early (baseline to week 12) CD4+ T-cell recovery.
- The LPV/r + RAL arm will have greater decreases in early (baseline to week 4) CD4/CD8 T-cell immune activation and apoptosis which will be associated with greater late (week 12 to week 48) CD4+ T-cell recovery.
- Subjects treated with LPV/r + RAL arm will have smaller changes in total cholesterol and triglycerides from baseline than those receiving EFV/TDF/FTC.
|Condition or disease
|HIV Infections
|Drug: Kaletra + Isentress Drug: Atripla
|Phase 2
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|50 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Nucleoside-Sparing Combination Therapy With Lopinavir/Ritonavir (LPV/r) + Raltegravir (RAL) vs. Efavirenz (EFV) + Tenofovir Disoproxil Fumarate + Emtricitabine (TDF/FTC) in Antiretroviral-Naïve Patients
|Study Start Date :
|September 2008
|Actual Primary Completion Date :
|November 2010
|Actual Study Completion Date :
|November 2010
Experimental: 1
Kaletra (lopinavir/ritonavir 400/100 mg) + Isentress (Raltegravir 400 mg) twice-daily
Drug: Kaletra + Isentress
kaletra 2 tabs twice a day + Raltegravir 1 tab twice a day
Other Name: lopinavir ritonavir raltegravir
Active Comparator: 2
Sustiva (EFV 600 mg), Viread (TDF 300 mg) and Emtriva (FTC 200 mg) taken as Atripla® once-daily
Drug: Atripla
Atripla 1 tab once a day
- To compare the phase 1 viral decay rates between LPV/r + RAL vs. EFV/TDF/FTC treatment combinations. [ Time Frame: 14 days ]
- To determine the antiviral efficacy of LPV/r + RAL compared to EFV/TDF/FTC after 48 weeks of treatment. [ Time Frame: 48 weeks ]
- To compare early (baseline to week 12) and late (week 12 to week 48) CD4+ T-cell recovery rates between treatment regimens. [ Time Frame: 48 weeks ]
- To evaluate the association of phase 1 viral decay dynamics (baseline to day 14) on phase 1 (baseline to week 12) CD4+ T-cell recovery. [ Time Frame: 12 weeks ]
- To evaluate the association of early changes in immune subsets (baseline to week 4) on phase 2 (week 12 to week 48) CD4+ T-cell recovery [ Time Frame: 48 weeks ]
- To evaluate the safety and tolerability of this novel nucleoside-sparing combination of LPV/r + RAL compared to EFV/TDF/FTC therapy [ Time Frame: 48 weeks ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Documented HIV-1 infection.
- Treatment naïve (defined as having never received any HIV antiretroviral agents in past).
- CD4+ T-cell count greater than or equal to 50 cells/mm3
- HIV viral load greater than or equal to 5,000 copies/mL
Laboratory values obtained by screening laboratories within 30 days of entry:
- Absolute neutrophil count (ANC) greater than 750/mm3.
- Hemoglobin greater than 8.0 g/dL.
- Platelet count greater than 50,000/mm3.
Calculated creatinine clearance (CrCl) > 60 mL/min as estimated by the Cockcroft-Gault equation:
- For men, (140 - age in years) x (body weight in kg) ÷ (serum creatinine in mg/dL x 72) = CrCl (mL/min)
- For women, multiply the result by 0.85 = CrCl (mL/min)
- AST (SGOT), ALT (SGPT), and alkaline phosphatase less than 5 x ULN.
- Total bilirubin less than 2.5 x ULN.
- Females of childbearing potential must have a negative serum pregnancy test at screening and agree to use a double-barrier method of contraception throughout the study period.
- Men and women age greater than or equal to 18 years.
- Ability to obtain prescription for HIV antiretroviral medications and to have required prescriptions filled prior to entry.
- Ability and willingness of subject to give written informed consent
Exclusion Criteria:
- Pregnancy or breast-feeding
- Serious illness requiring systemic treatment and/or hospitalization until subject either completes therapy or is clinically stable on therapy, in the opinion of the investigator, for at least 30 days prior to study entry (day 0).
- Acute therapy for serious infection or other serious medical illnesses (in the judgment of the site investigator) requiring systemic treatment and/or hospitalization within 14 days prior to study entry (day 0).
- Evidence of HIV seroconversion within 6 months prior to study entry.
- Evidence of any major HIV drug resistance-associated mutation on any genotype performed prior to study entry or at the time of screening.
- History of chronic hepatitis C (defined as HCV antibody positive and HCV RNA detectable).
- History of chronic active hepatitis B (defined as surface antigen positive and/or HBV DNA detectable).
- Active drug or alcohol use or dependence that, in the opinion of the investigator, would interfere with adherence to study requirements.
- Use of any immunomodulator, HIV vaccine, or investigational therapy within 30 days of study entry.
- Use of human growth hormone within 30 days prior to study entry.
- Initiation of testosterone or anabolic steroids within 30 days prior to study entry. (Exception: Chronic replacement dosages in patient's with diagnosed hypogonadism is allowed).
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00752856
|United States, California
|Living Hope Clinical Foundation
|Long Beach, California, United States, 90813
|University Southern California
|Los Angeles, California, United States, 90033
|Univerisity California Irvine
|Orange, California, United States, 92868
|Desert AIDS Project
|Palm Springs, California, United States, 92262
|University California San Diego
|San Diego, California, United States, 92103
|Torrance, California, United States, 90502
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|California Collaborative Treatment Group
|ClinicalTrials.gov Identifier:
|NCT00752856 History of Changes
|Other Study ID Numbers:
|First Posted:
|September 16, 2008 Key Record Dates
|Last Update Posted:
|April 2, 2014
|Last Verified:
|March 2014
HIV treatment
RNA Virus Infections
Virus Diseases
HIV Infections
Lentivirus Infections
Retroviridae Infections
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Raltegravir Potassium
Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
HIV Protease Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
HIV Integrase Inhibitors
Integrase Inhibitors


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SAVANNAH, GA (March 6, 2012) - The Sacred Heart men's and women's golf teams opened the 2012 spring season playing at the Lonnie Barton Invitational at The Club at Savannah Harbor hosted by LIU Brooklyn. Both the Pioneer men and women finished second at the event.
On the men's side, SHU led after day one, shooting a team score of 309. On Tuesday, the Pioneers carded a 308 but High Point shot a 292 to win the event with a two-day score of 605. For the women, the Pioneers were in second place after day one's 333, trailing the host Blackbirds by six strokes. LIU held on for the win with a second day score of 320, holding off the Pioneers who shot a 326 for two day score of 659.
Two Pioneers finished in the top-10 in the field of 40 golfers in senior Leopoldo Garcia (Guaynabo, Puerto Rico) and junior Josh Salah (Gloucester, MA). Garcia finished second shooting a 75 on day one and a 73 on day two. Salah finished fourth with a two-day total 152 (77-75).
For the women, seniors Gabriella Riber (Stockholm, Sweden) and Carly Bergin (Binghamton, NY) finished second and third respectively. Riber shot a 76 on day one and finished with a two day total of 157, two strokes off the winning score posted by LIU's Cristina Santamaria. Bergin was one stroke back, carding an 81 on Monday and a 77 on Tuesday.
The Pioneer men are back in action at the Fireline Towson Invitational. The SHU women are up next at the C&F Bank Invitational in Williamsburg, VA.


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I hate the guy. I don't know why, maybe it's the sad look on his elephant mask. (I'd had that look too If I had to wear that mask in public)
Sure the staction made Snout Spout LOOK cool, but since This is MOTUC, more vintage features might appear on the sad Eternian Firefighter...
We know that there will be no Action Features so no squirting water.
What could the 4H do with him? (IF we even get to him.)
I can see them using the Standard male body(maybe Hordak's lower ab piece) He-Ro's loincloth
Hopefully Using Trap Jaw/Kronis arms and legs and new gloves and feet similar to the staction.
A head with poseable trunk (Hopefully more like the staction)
His Axe and a clip on attachment for his trunk to simulate a stream of water.
So let's talk about Snout Spout!! Show your love/hate/indifference towards the guy...


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guardian(redirected from legal guardian)
Also found in: Dictionary, Thesaurus, Medical, Financial, Encyclopedia, Wikipedia.
A person lawfully invested with the power, and charged with the obligation, of taking care of and managing the property and rights of a person who, because of age, understanding, or self-control, is considered incapable of administering his or her own affairs.
n. a person who has been appointed by a judge to take care of a minor child (called a "ward") or incompetent adult personally and/or manage that person's affairs. To become a guardian either the party intending to be the guardian or another family member, a close friend or a local official responsible for the child's welfare will petition the court to appoint the guardian. In the case of a minor, the guardianship remains under court supervision until the child reaches 18. Naming someone in a will as guardian of one's child in case of the death of the parent is merely a nomination. The judge does not have to honor that request, although he/she usually does. Sadly enough, often a parent must petition to become the guardian of his/her child's "estate" if the child inherits or receives a gift of substantial assets, including the situation in which a parent gives his/her own child an interest in real property or stocks. Therefore, that type of gift should be avoided, and a trust created instead. While the term "guardian" also may refer to someone who is appointed to care of and/or handle the affairs of a person who is incompetent or incapable of administering his/her affairs, this is more often called a "conservator" under a conservatorship. (See: conservator, ward)
guardiannoun argus, attendant, bodyguard, champion, chaperon, conductor, conservator, custodian, custos, defender, defensor, escort, guard, keeper, overseer, patron, praeses, preserver, protector, safeguard, safekeeper, sentinel, sponsor, superintendent, supervisor, trustee, tutelar, warden, warder, watchman
Associated concepts: de facto guardian, domestic guardian, general guardian, guardian ad litem, guardian by statute, guardian de son tort, guardian of the person, legal guardian, special guardian, testamentary guardian
Foreign phrases: Tuta est custodia quae sibimet creditur.That guardianship is secure which trusts to itself alone. Lucrum facere ex pupilli tutela tutor non debet. A guardian ought not to make money out of the guardianship of his ward. Custos statum haeredis in custodia existennis meliorem, non deteriorem, facere potest. A guardian can make the estate of an existing heir under his guardiannhip better, but not worse. Minor minorem custodire non debet, alios enim praesumitur male regere qui seipsum regere nescit. A minor ought not to be guardian to a minor, for a person who knows not how to govern himself is preeumed to be unfit to govern others.
See also: administrator, caretaker, custodian, fiduciary, patron, protective, sponsor, superintendent, trustee, warden


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Homemade Biscuits with Sour Cream, Chives and Parmesan
Sunny and I woke up very early this morning to prepare a festive brunch for the whole family. We made some fresh juices, smoothies, crêpes, hashbrowns and sour cream biscuits. Making biscuits is a little messy but so worth it. Our family is very fond of buttermilk biscuits, but sour cream biscuits are even more decadent and delicious. The sour cream imparts a tangy flavor and richness that is hard to beat. We flavored the biscuits with parmesan cheese and garlic chives from the garden.
I don't know if I've mentioned it, but my Aunt Elise is visiting us from Vietnam. She's never had biscuits before, and so she looked at the little rounds of bread with curiosity. After she took her first bite, she was absolutely hooked. Biscuits truly are universal in their appeal.
Yields: 25 biscuits4 cups flour (see tips)
4 teaspoons cream of tartar
2 teaspoons baking soda
1-1/4 teaspoons kosher salt
2 teaspoons sugar
2 teaspoons granulated garlic (garlic powder)
1 cup vegetable shortening (16 tablespoons), diced
3 tablespoons butter, cold
2 cups sour cream
3-1/2 tablespoons half and half, as needed
1/2 cup fresh garlic chives, finely snipped
6 tablespoons parmesan cheese, freshly grated
1/2 teaspoon white pepper, freshly ground
1 egg
Preheat the oven to 400°F.
For the dry ingredients:
Reserve about 1 tablespoon of flour for rolling the dough on the pastry board.
In a bowl, combine the flour, salt, sugar, cream of tartar and baking soda. Sift all the dry ingredients.
For the biscuit dough:
Reserve about 2 tablespoons of diced shortening.
In a bowl of a stand-mixer (or a large mixing bowl), place the dry ingredients. Grate the butter over the bowl using a cheese grater. Add the diced shortening. Mix the ingredients using the dough hook attachment of the stand-mixer (if you don't have one, the back of a fork works fine as well). Start with the lowest speed of the machine. Once all the butter pieces are coated with flour, add the sour cream, granulated garlic, 5 tablespoons of grated parmesan, white pepper and the chives. Mix until coarsely blended and still crumbly. Remove the bowl from the stand-mixer. Incorporate 2 to 2-1/2 tablespoons of half and half and the reserved shortening to the biscuit mixture. Do NOT over-mix; otherwise the biscuits will have a dense texture.
Sprinkle flour over a pastry board and transfer the biscuit dough. Using a rolling pin, even out the dough to about a 1-inch thickness. Create 23 disks using (2-5/8-inch diameter or 68 millimeters) biscuit cutters and form the last 2 disks with the remnants of dough (knead the dough as little as possible).
For the egg wash:
Using a fork, beat the egg with a tablespoon of half and half. Lightly brush the egg wash over the biscuits. Make sure to coat the entire outer surface. Sprinkle with the remaining grated parmesan.
Assembly time:
Place the biscuits on a baking sheet, previously lined with a silicone mat or parchment paper. Bake for 22-23 minutes.
Serve warm with a basil and chive flavored-butter, chive sour cream dip (see tips), gravy on the side or a sweet potato and roasted bell pepper soup.
Bon appétit!
The traditional way of making baking powder is by combining 1 part of baking soda and 1 part of cornstarch to 2 parts of cream of tartar. Corn starch is often used as a thickening agent and is not necessary in this recipe. You can always use baking powder if you don't have baking soda and cream of tartar on hand.
For the perfect texture, it's preferable to combine 3 cups of all-purpose flour and 1 cup of cake flour but if you like, you can also use 4 cups of all-purpose flour.
To ensure that the mixture remains cold, it's preferable not to knead the dough by hand.
The biscuits have a fluffy texture, thanks to the use of vegetable shortening and a buttery flavor from the addition of real butter. My trick is to place the butter in the freezer and grate the butter using a cheese grater. No need to grate the shortening; incorporating diced shortening helps create a flakier texture and a puffier result.
For a stronger butter flavor, I used butter-flavored shortening. And for easy measurement, I used shortening sticks.
Sifting dry ingredients helps to eliminate nasty lumps of flour and aerate the mixture when liquid is added. It's an important step when baking in order to get a moist result.
We made biscuits with both (2-5/8-inch diameter or 68 millimeters) regular and fluted biscuit cutters.
I added 2 tablespoons of half and half to thin the biscuit dough because of the thickness of the sour cream. You want the biscuit dough to be wet and rather sticky.
I've never tried making biscuits with crème fraîche but I'm pretty sure they'd be as rich as the ones with sour cream.
You can skip the step with the egg wash for anyone who's allergic to eggs and brush the biscuit with only half and half or melted butter. The egg wash gives a finished golden, glazed look and shine to the biscuits. It also helps the parmesan garnish to stick to the outer surface. You can also replace the half and half with cream, milk or water.
How to make chive and sour cream dip: In a small bowl, soften 2 ounces of cream cheese with 6 tablespoons of sour cream. Thin the mixture with the juice of half a lime (without the pulp). Add about a tablespoon of finely snipped garlic chives and a teaspoon of garlic powder. Season with salt and white pepper. Transfer to a dipping bowl. Garnish with additional garlic chives. Voilà!
Published By: on November 14, 2009.