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Clinical Islet Xenotransplantation
How Close Are We?
Type 1 diabetes (T1D) is a major health problem throughout the world. In the U.S., it is estimated that about 1.5 million people suffer from T1D. Even when well controlled—by frequent monitoring of blood glucose and administration of insulin, the long-term complications of the disease are significant and include cardiovascular disease, nephropathy, retinopathy, and neuropathy (1). Here we review recent progress in preclinical models of pig islet xenotransplantation and discuss the remaining challenges that need to be addressed before the application of this form of therapy can be established in patients with T1D.
During the past decade, islet allotransplantation alone (without previous kidney transplantation) using deceased human donor pancreata has been indicated mainly in patients who have had T1D for >5 years with life-threatening hypoglycemic episodes and wide fluctuations in blood glucose levels. Although the initial long-term results were rather disappointing (2), the results of islet allotransplantation have improved significantly in recent years, with 5-year insulin-independent normoglycemia achieved in >50% of patients at experienced centers (3). There is increasing evidence that successful islet allotransplantation greatly reduces the incidence of hypoglycemic episodes (2) and reduces or slows the incidence of late complications of T1D (4). This may extend the indications for islet transplantation to patients with progressive complications. For example, islet transplantation in a patient with preterminal renal failure may prevent disease progression, possibly avoiding the need for hemodialysis and kidney transplantation, provided that nonnephrotoxic immunosuppressive drug therapy is administered.
Currently, in the U.S., the median waiting time for a kidney allograft from a deceased human donor is >4 years (5). However, islets from two deceased human donor pancreata are frequently required to achieve normoglycemia in a diabetic patient. Because of the limited number of suitable deceased donor pancreata, the overall number of treated patients is small, with fewer than 1,000 procedures carried out in Western countries during the past 10 years (2). It is likely that the demand for this procedure will increase, resulting in a growing need for new sources of islets for transplantation. Although there is a prospect that this need can be filled by islets from pigs (Sus scrofa), it is unlikely that nonhuman primates (NHPs) will be used for this purpose because there are significant concerns associated with ethics, logistics, and, potentially, safety.
The first scientific attempt to transplant pig islets into patients with T1D by Groth et al. (6) in 1994 resulted in detectable pig C-peptide in urine beyond 300 days and insulin-positive staining of graft biopsies in patients receiving combined human kidney and pig islet transplants. Despite these results, glucose metabolism remained unaltered. In Mexico, pediatric diabetic patients have been transplanted with pig islets that were co-transplanted with Sertoli cells placed in a stainless steel chamber that was implanted under the skin (7). In New Zealand, pig islets have been encapsulated individually in alginate and transplanted into the peritoneal cavity, an immunoisolating approach that avoids the need for immunosuppressive therapy (8). A trial of this approach is underway with appropriate regulatory oversight, and publication of the results is anticipated.
Regardless of the results of these xenotransplantation trials, lively discussion about their justification on regulatory and ethical grounds has emerged. Whereas the level of regulatory oversight of the Mexican trial was likely insufficient, the trial in New Zealand is being regulated carefully by that country's Ministry of Health (8). Nevertheless, none of these clinical studies was preceded by peer-reviewed, preclinical data in NHPs proving the efficacy of the therapy. The World Health Organization and the International Xenotransplantation Association have both stressed that, in addition to the need for strict procedures to guarantee a safe pig product, patients should be exposed to islet xenotransplantation only if there is a relatively high expectation of benefit (9,10). Although convincing preclinical data from experiments in NHPs was not required in the past before the introduction of islet allotransplantation, these data remain the best indication of the potential therapeutic benefit of islet xenotransplantation. In recent years, significant progress has been made, with pig islets providing sustained (>1 year) normoglycemia in a small number of NHPs in which diabetes had been induced.
Six groups have independently reported that pig islets transplanted into NHPs can maintain normoglycemia for periods in excess of 6 months (Table 1) (refs. 55–59). When free islets have been transplanted, immunosuppressive therapy has been essential to prevent rejection. When encapsulated islets have been transplanted, however, encouraging results have been achieved in the absence of immunosuppressive therapy (11). Furthermore, 6-month graft survival has been achieved after either adult or neonatal free islet transplantation, as well as after fetal pancreas transplantation (Table 1). Collectively, these results indicate that there is reason to believe that pig islet xenotransplantation, either of free islets or encapsulated islets, will be clinically successful in due course.
Successful clinical application of islet xenotransplantation currently is inhibited by a number of barriers. These include the immediate loss of islets in an instant blood-mediated inflammatory reaction (IBMIR) and strong T cell–mediated rejection, requiring the use of excessive immunosuppression. The optimum age of donor pigs (e.g., fetal, neonatal, or adult) and the optimum anatomical site for transplantation are the subject of ongoing investigation. We discuss recent insights into these challenges and propose strategies to overcome them.
Inflammation after islet xenotransplantation.
The initial hurdle faced by islets transplanted into the portal vein is IBMIR, which results in significant destruction of islets within minutes. IBMIR is believed to be a nonspecific (i.e., nonimmune) inflammatory response related to the transplantation of islets directly into the blood stream of the portal vein, which is the current site for clinical islet transplantation. Isolated islets can express tissue factor, which activates coagulation. As a result, platelets and complement are activated and the islets become infiltrated with neutrophils and macrophages (12) (Fig. 1). The extent of tissue factor expression on the islet graft negatively correlates with the clinical success of allotransplantation (13). Incompatibilities between the human and pig coagulation-anticoagulation systems render IBMIR even more problematic in xenotransplantation. Inhibition of tissue factor expression or thrombin formation prevented islet damage in vitro (14,15). However, in vivo, anticoagulation does not fully prevent IBMIR (12).
When wild-type pig organs (rather than islets or cells) are transplanted in NHPs, they are subject to hyperacute rejection. The vascular endothelium of pigs expresses the important galactose-α1,3-galactose (Gal) oligosaccharide against which humans have natural anti-Gal antibodies (16). The binding of antibodies to Gal antigens results in almost immediate complement activation, with ensuing destruction of the graft. Although fetal and neonatal pig islets express Gal, the expression of Gal on islets is reduced as the pig matures (17). It was, therefore, originally anticipated that hyperacute rejection might not occur after transplantation of adult pig islets, although that concept is now being questioned.
Although it was first concluded that complement activation in IBMIR occurred mainly through the alternative pathway (18), recent studies suggest that human preformed IgM and IgG antibodies bind to human and, particularly, pig islets and activate complement through the classical pathway (19,20). In patients with preformed antibodies, particularly when there are high antibody titers against foreign human leukocyte antigens, success rates in achieving sustained normoglycemia after islet allotransplantation have been lower (21).
Neonatal pig islets express Gal, making them a target of anti-Gal antibodies. Neonatal islets from pigs that do not express Gal, that is, α1,3-galactosyltransferase gene-knockout (GTKO) pigs, are less susceptible to IBMIR in an NHP model (22). The expression of Gal on adult pig islets is low (13), suggesting that antibody binding to other (i.e., non-Gal) antigens may be an initiating factor in complement activation. These results suggest that IBMIR is less "nonspecific" than previously anticipated and involves a mechanism comparable to the hyperacute rejection of a pig organ.
To date, the identity of non-Gal antigens on pig islets has not been determined, although N-glycolylneuraminic acid is likely to be a target when clinical xenotransplantation is undertaken. However, this oligosaccharide is not important in pig-to-NHP islet transplantation because NHPs also express it and therefore do not produce natural antibodies against it (23).
Rejection of pig islets by the adaptive immune sys-tem.
After the IBMIR, and likely driven, in part, by this event, the adaptive immune response to xenografted islets is largely T cell–mediated (24). Success in NHPs has been achieved only when costimulatory signals between antigen-presenting cells and T helper cells are blocked, especially with an anti-CD154 monoclonal antibody (mAb). Unfortunately, the increased risk of thromboembolic complications with the use of anti-CD154 mAb (25) prevents this biological from being applied clinically, and alternative strategies are warranted.
The autoimmunity associated with T1D is caused by self-reactive T and B cells directed against proteins expressed in pancreatic β-cells. Proinsulin, islet antigen-2, glutamic acid decarboxylase-65 and -67, and islet cell autoantigen of 69 kDa are the major targets. After allotransplantation of islets, autoimmune lymphocytes can react against the same antigens expressed on grafted islets, thereby contributing to graft failure (26). Although it is largely unknown whether this will occur after islet xenotransplantation, T cells from patients with T1D proliferate when incubated with fetal pig islet-like cell clusters (27), and they are specifically directed against pig glutamic acid decarboxylase. It can be anticipated, therefore, that xenografted pig islets will be subjected to autoimmune activity, as well as xenoimmune activity, to some extent.
The current evidence is that pig islet transplantation, even if associated with xenosensitization, would not lead to sensitization against alloantigens, and therefore would not compromise subsequent islet or kidney allotransplantation (reviewed in Cooper et al. [28]).
Donor age and preparation of pig islets.
Significant debate has taken place about whether the ideal islets for clinical transplantation should be from fetal, neonatal, or adult pigs (Table 2). It generally is known that adult pig islets are more difficult to isolate successfully than adult human islets. In young adult pigs (<2 years old), islets are smaller than in pigs >2 years old, making them more likely to become fragmented during the isolation procedure and reducing their in vitro and in vivo functional capacities (29). Although isolation procedures for adult islet donors have improved significantly, pigs aged >2 years, particularly retired breeder sows, may have certain benefits. The period of ex vivo culture of adult islets between isolation and transplantation has ranged from 16 to 48 h (24,30).
Neonatal islets may be preferred for several reasons (Table 2), including their higher resistance to hypoxia (31). From a logistical perspective, it is preferable to recover the pancreas from neonates during the first week of life (usually at 1–3 days of age [22,32]) than to maintain pigs under barrier conditions in a "clean" environment for >2 years, an approach that is space- and time-consuming as well as expensive. However, logistical success may depend on methods to store or cryopreserve neonatal islets. After isolation, the current approach is for the so-called neonatal islet cell clusters to be maintained in culture for 7 days, during which they proliferate, a consideration that is also important after transplantation (32).
Recent data indicate that fetal pancreata, excised at 42 days of fetal life, can result in successful implantation after transplantation into NHPs (32). However, it can take up to 5 months for the tissue to become fully functional (32), a period during which patients would be required to maintain insulin therapy as well as immunosuppressive therapy. Moreover, a large number of fetal pigs (60 fetuses as extrapolated from studies of NHP recipients [33]) would be required to provide sufficient tissue to induce normoglycemia in a single adult human.
The number of free pig islets needed to achieve normoglycemia in NHPs has been estimated at ≥25,000 islet equivalents (IEQ)/kg for adult islets and ≥50,000IEQ/kg for neonatal islets (22,24). This is significantly in excess of the number of human adult islets needed in clinical allotransplantation (10–15,000 IEQ/kg). The exact number of islets required to cure diabetes in humans is as yet uncertain, but with the numbers of pig IEQ per kilogram in NHPs, and based on a yield of 400,000 IEQ per adult pig (29), islets from several adult pigs may be required to cure one patient. However, islets from neonatal pigs maintain a proliferative capacity after transplantation (32), which may result in a functional islet mass after transplanting a smaller number of islets.
Alginate encapsulated pig islets (30,000 IEQ/kg), loaded onto a macrodevice and placed subcutaneously, reversed diabetes in NHPs (11). This is an attractive approach because encapsulation prevents the need for immunosuppressive therapy. However, several technical challenges need to be overcome, including degradation of capsules over time, reduced islet viability inside the capsules from a lack of nutrients, induction of antipig antibodies, and possibly humoral rejection.
Genetic engineering of pigs.
Our ability to genetically engineer pigs has increased significantly during the past 20 years, resulting in the production of pigs with different genetic modifications (Table 3) (refs. 61–74). These pigs can be cross-bred to produce an "ideal" pig for islet transplantation. The genetic engineering of pigs currently is aimed at providing resistance to the effects of IBMIR and to both the innate and adaptive immune responses.
Although encouraging results have been reported after transplantation of wild-type (unmodified) pig islets into NHPs, it is almost certain to be advantageous (particularly if fetal or neonatal islets are to be transplanted) to transplant islets from GTKO pigs. Development of methodology to disrupt the GT gene (34), in combination with cloning techniques (35), resulted in the first GTKO pigs in 2003 (36). A recent report indicates that there is less antibody binding and immediate injury to neonatal islets from these pigs compared with those from wild-type pigs (22). Therefore, the background for pigs to be used for clinical islet transplantation is likely to be GTKO (particularly when neonatal pig islets are used), but expression of one or more human complement-regulatory proteins (hCRPs), for example, CD46, CD55, and CD59, also will be advantageous (30). Thus, the deleterious effects of anti-Gal antibody binding will be obviated, and, although the anti–non-Gal antibody will bind to the pig islets, its effects will be mitigated by the protection offered by hCRP expression.
Theoretically, it would seem worthwhile to have GTKO/hCRP pigs in which one or more anti-inflammatory genes also are expressed, for example, CD39, heme oxygenase-1, and A20. To help diminish the IBMIR, expression of one or more "antithrombotic genes" (e.g., tissue factor pathway inhibitor, thrombomodulin) is likely to prove beneficial. Cells from pigs in which the major histocompatibility complex class II transactivator has been knocked down (CIITA-DN pigs) also are likely to reduce the direct T cell response to swine leukocyte antigen class II (Table 3), which is expressed on a subset of islet cells (37).
Genes can be specifically expressed in islets with the use of an insulin promoter. Expression of molecules for blockade of costimulatory pathways, such as porcine or human cytotoxic T-lymphocyte antigen 4 (CTLA4)-Ig, might provide local protection from the T cell–mediated response (Table 3). Pigs with multiple genetic modifications (e.g., GTKO/hCD46/hTFPIIns/pCTLA4-IgIns, with and without hCD39Ins) currently are available (Fig. 2), and islets from such pigs adequately correct hyperglycemia in diabetic monkeys (Fig. 3C) in an ongoing trial at our center.
Immunosuppressive drug regimen.
To date, a clinically applicable immunosuppressive drug regimen that can prevent the xenoimmune response has not been established. In particular, an alternative to the efficacious but clinically inapplicable anti-CD154 mAb remains an obstacle. Thromboembolic complications possibly could be prevented using a fragment crystallizable region–disabled mAb (38).
Other costimulatory blockers, such as CTLA4-Ig, may be effective, especially when used in combination with endogenous "immunosuppressive" genetic manipulations (CTLA4-IgIns, CIITA). Alemtuzumab for deep lympho-depleting induction therapy currently is included in the most successful clinical regimens for islet allotransplantation. We have recently developed an NHP model for the use of alemtuzumab (39), and we plan to use alemtuzumab in our next islet xenotransplantation experiments.
Alternative anatomical sites for islet transplantation.
Even though the pig could provide an unlimited supply of islets, the inefficiency of islet transplantation into the portal vein resulting from IBMIR remains an obstacle for applying islet xenotransplantation on a clinical scale. To avoid or minimize IBMIR, an alternative approach is to place the islets in a site where they are not immediately exposed to blood, and investigation in this area is ongoing. A number of sites have been investigated, some of which seem worthy of continued assessment.
Transplantation into the gastric submucosal space can be achieved through endoscopy (40) and offers the advantage of possible endoscopic biopsy of the graft for investigation of rejection, apoptosis, or both (41). Intramuscular transplantation has already reached the clinical stage in islet autotransplantation (42). In diabetic monkeys, islets loaded onto a biodegradable scaffold, wrapped with omentum and placed between abdominal muscle layers, resulted in significant metabolic improvement in allotransplantation experiments (43).
After infusion into the portal blood stream, transplanted islets depend heavily on diffusion of oxygen from the hypoxic portal blood until revascularization (mainly from the hepatic artery) is completed, a process that may take up to 14 days (reviewed in Jansson and Carlsson [46]). Both donor intra-islet endothelial cells and recipient endothelial cells contribute to this process (47,48).
Pig insulin differs from human insulin by only one amino acid and it was administered to patients with T1D for many years before recombinant human insulin became available. Nevertheless, there are differences in glucose metabolism among pigs, NHPs, and humans, and these have been discussed by Casu et al. (48). In pigs, fasting blood glucose values are higher and C-peptide levels are lower when compared with values in cynomolgus monkeys (48) (Fig. 4). As a result, when pig islets are transplanted into monkeys they have to perform at "supraphysiologic" levels. Nevertheless, maintenance of normoglycemia for >1 year after pig islet transplantation in a diabetic monkey has already been demonstrated (30) (Fig. 3). Because C-peptide levels in humans lie between those in the pig and monkey, it may be easier to achieve and maintain normoglycemia in humans after pig islet xenotransplantation using fewer islets per kilogram of body weight than in NHPs (49).
Pigs that will be used for clinical islet transplantation are almost certainly going to be genetically engineered, even in the case of encapsulated islets. Accordingly, it is important to ascertain that islet function in these genetically engineered pigs remains within the normal range for pigs. Glucose metabolism has been investigated in GTKO pigs and has been found to be similar to that in wild-type pigs (50). More recently, pigs have become available to us (through Revivicor, Blacksburg, VA) that, through the use of an insulin promoter, have transgenes that are expressed selectively in the β-cell of the islets. Our initial studies indicate that glucose metabolism in these pigs is similar to that in wild-type pigs.
After islet allotransplantation, aggregation of islet amyloid polypeptides in the transplanted islets can promote amyloidosis and β-cell apoptosis. Differences in the amyloid polypeptide sequence between humans and pigs may explain observations showing a lack of amyloid formation after porcine islet transplantation, indicating improved survival (51) (Fig. 5).
Safety has been discussed for many years; much of the discourse has focused on the potential for the transfer of pig microorganisms to the islet recipient and, more importantly, to the general population. Guidelines from U.S. regulatory authorities direct that pig donor organs and cells must be free of specified bacteria, viruses, protozoa, and fungi (52). Breeding and housing of pigs in biosecure barrier facilities can eradicate many pathogens with zoonotic capabilities. For example, porcine cytomegalovirus (pCMV) can be excluded relatively easily from the islet source herd by early weaning from the sow (53). Although rare, occasional isolated pig islets have tested positive for pCMV (54), potentially constituting a risk for patients receiving immunosuppressive therapy. However, active transmission into NHPs after islet transplantation has not been documented. Efforts to continue testing for pCMV and to exclude it from the pig herd are warranted.
Even if the pigs are housed in an ideal "clean" barrier environment, they will inevitably carry the porcine endogenous retrovirus, which is integrated in the genome of pig cells and therefore will be transplanted with the islets. However, monitoring of humans exposed to pig tissues and cells and of NHP recipients of pig grafts has never identified active replication of the porcine endogenous retrovirus (10). Currently, transfer of this virus is not considered to be a serious risk, and although national regulatory authorities (e.g., the U.S. Food and Drug Administration) will insist on monitoring for the virus, these bodies are unlikely to preclude clinical xenotransplantation on the basis of the presence of the virus alone (52). Furthermore, if absolutely essential, techniques of small interfering RNA have been developed in which activation of the virus could be prevented successfully after transplantation (55).
Because the need for clinical islet xenotransplantation may be considerable—with several thousand patients benefitting from the procedure each year—housing of pigs under barrier conditions will be expensive. In the U.S., a barrier facility to house even 100 pigs may cost US$10 million to erect, and approximately $1–2 million annually to maintain. Because islets will be isolated from the excised pancreas and subsequently cultured (possibly for 1–3 weeks in the case of neonatal pig islets), it could be argued that testing of the islets alone—the ultimate xenograft "product"—for the presence of microorganisms will be sufficient to ensure that the cells to be transplanted are safe. If this proves to be the case and is acceptable to regulatory authorities, then source pigs may not need to be maintained under such rigorous conditions. Regardless, a "clean" environment and regular monitoring of the pigs for microorganisms obviously will be essential.
Regulatory requirements relating to xenotransplantation are intricately interwoven with the microbiologic safety of the procedure itself and will require additional discussion when immunologic problems have been overcome and clinical islet xenotransplantation is fully warranted.
With the increasingly promising results from both clinical islet allotransplantation and experimental islet xenotransplantation, we can be cautiously optimistic that genetically engineered pigs will provide islets in sufficient numbers to allow treatment of T1D within years rather than decades. Just as with allotransplantation, patients with episodes of severe hypoglycemia or patients with stable kidney grafts probably would be the first candidates. However, problems associated with IBMIR need to be overcome, either by further genetic manipulation of the pig islets, therapy with drugs that reduce its severity, or identification of a successful alternative site for islet transplantation.
Against this backdrop, it should be stressed that the need for intensive, long-term immunosuppressive therapy needs to be reduced. This might be achieved by successful encapsulation or by further genetic engineering of the pig that will provide at least some local "endogenous" protection from the T cell immune response. The more that the pig islets can be genetically manipulated in this respect, the less exogenous immunosuppressive therapy will be required.
We suggest that the transplantation of islets from GTKO/hCD46/pCTLA4-IgIns/TFPIIns/hCD39Ins pigs combined with an effective, clinically applicable immunosuppressive regimen (e.g., induction alemtuzumab and maintenance tacrolimus and mycophenolate mofetil, which is currently associated with favorable results after clinical islet allotransplantation [3]) may be sufficiently successful in an NHP model to fulfill published criteria for a clinical trial (9). Results of such studies of NHPs should be available within the next 18 months. If the results do not fulfill the criteria for a clinical trial, then testing of pigs with further genetic modification, for example, expression of heme oxygenase-1, and alternative immunosuppressive regimens will be required.
D.J.v.d.W. is supported by a research grant from the American Society of Transplantation and by the Derek Gray Traveling Scholarship Award of the International Pancreas & Islet Transplant Association. B.E. is the recipient of a National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases training grant (T32-AI-074490). H.H. is the recipient of an NIH RO3 grant (AI-096296). Work on xenotransplantation at the University of Pittsburgh has been supported in part by Department of Defense Grant W81XWH-06-1-0317 (M.T.), Juvenile Diabetes Research Foundation Grant 6-2005-1180 (M.T.), NIH grants U19-AI-090959-01, U01-AI-068642, and R2-1A-1074844 (D.K.C.C.), and by Sponsored Research Agreements between Revivicor, Inc., Blacksburg, VA, and the University of Pittsburgh. D.A. and C.P. are employees of Revivicor, Inc., a subsidiary of United Therapeutics. No other potential conflicts of interest relevant to this article were reported.
D.J.v.d.W. and D.K.C.C. selected the topics for review, performed the main literature search, coordinated the contributions of the coauthors, contributed to sections about immunology, and provided data for Figs. 2 through 5. B.E., H.H., N.M., and F.G.L. contributed to sections about immunology. R.B., M.W., A.C., and M.T. contributed to sections about islet isolation and culture and physiology. G.K. and M.E. contributed to sections about alternative sites and immunomodulation. B.E. provided Table 3. G.K., H.H., M.E., C.P., and D.A. contributed to sections about genetic engineering. R.B., A.C., C.P., D.A., and M.T. provided data for Figs. 2 through 5. All authors contributed to the writing of the manuscript and approved the final version.
- Received January 11, 2012.
- Accepted June 6, 2012.
- © 2012 by the American Diabetes Association.
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.


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No team likes to lose.
But the experience the Salesian High girls basketball team gathered in a 64-56 loss to perennial powerhouse St. Mary's-Stockton on Saturday could prove beneficial in the future for the Pride.
Salesian coach Steve Pezzola said Tuesday that it's the best his team has played all season.
"I thought that we played with a lot of heart and a lot of character," said Pezzola, whose squad is ranked No. 6 in this week's Bay Area News Group East Bay girls basketball poll. "The chemistry of the team is starting to get to where I think it needs to be."
St. Mary's-Stockton, ranked No. 8 in the country by calpreps.com's Freeman Ratings, took a 20-9 lead at the end of the first quarter. But visiting Salesian rallied and led by one point with approximately four minutes to go in the fourth quarter, Pezzola said. He said the Pride executed better after the first quarter.
"Our girls stood up at that time and played them even, more than even, the rest of the way," he said.
The Pride has another big game this week, as they face St. Mary's-Berkeley (ranked No. 2 in the East Bay poll) on Friday at 8:30 p.m. at Saint Mary's College.
"It's always an interesting game because it's a rivalry game. But it's just one game in our league," Pezzola said about Friday's game. "They are a very good team and they are a challenge. I'm hoping that we will be up for the challenge."
Pride star Mariya Moore is one of the most complete players in the East Bay. The 5-foot-11 junior wing/point guard was averaging 17.6 points, 8.2 rebounds, 7.2 assists and 3.8 steals per game following Monday's win over El Cerrito.
Salesian's inside attack has also been fortified by the play of Zoe Correal, Deja Stallworth and Alana Horton. The three juniors combined to average 25.4 points and 18.0 rebounds per game after Monday.
Kian McNair is a floor leader for the team, and the Pride's depth has been bolstered by two transfers who became eligible on Jan. 1. Taylor Crowder transferred from American Canyon and Justice Toailoa played for Encinal last season. Both players are juniors.
MLK MADNESS: De La Salle's annual Martin Luther King Classic, which is now in its 16th year, has a way of bringing together the top local teams and will do so again. But it's not the only place to see quality boys basketball on Monday's holiday.
The Martin Luther King "I Have a Dream" Classic, which features teams from the Oakland Athletic League, will be played at Merritt College. The highlighted games will be the contests between Oakland and Castro Valley (6 p.m.) and McClymonds and San Leandro (7:30 p.m.).
At Dougherty Valley, a slate of games pitting teams from the East Bay Athletic League and Diablo Foothill Athletic League is highlighted by a 7 p.m. game between Dublin and Monte Vista.
It's still hard to top the Martin Luther King Classic at Haas Pavilion in Berkeley, particularly the final three games of the night. Sacramento battles Bishop O'Dowd in a showdown of Division III teams at 3:45 p.m.
The headliner comes at 5:45 p.m., when Salesian, the top-ranked team in the East Bay, faces De La Salle for the first time in recent memory. The Pride will be led by senior Jabari Bird, one of the top players in the country, who will be playing on his future home court at Cal. The Spartans are paced by Arizona-bound Elliott Pitts.
Kentucky-bound Marcus Lee and Deer Valley close out the night by facing Newark Memorial.
Discounted tickets are available through Friday via a presale at De La Salle or can be purchased at the door at full price. Doors open at 10 a.m.
Also a part of the holiday fun is the girls basketball event at St. Mary's-Stockton that includes a 5:30 showdown between defending state champions La Jolla Country Day and Bishop O'Dowd. The teams also met earlier this season, with the Dragons winning 65-43.
Staff writer Jimmy Durkin contributed to this notebook. Follow Phil Jensen at Twitter.com/JensenPhil and Jimmy Durkin at Twitter.com/Jimmy_Durkin.


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Inspired by real events, Molly Crows tells the story of a small town in Middle-England being torn apart, because of a wicked act that took place there centuries ago.
Based on the true story of a 17th Century witch and set in modern times. A seven year old girl avenges a wicked act, and tears a small town apart.
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Molly Crows - The Movie Trailer
Mercy Gaiger Feature
Mercy Gaiger began her acting career at the tender age of 3 when she expressed an interest is modeling for her parents (both of which were photographers). She proved so good at pulling faces and conveying emotion that she soon had a reputation amidst the alternative model/photographer community and the 'Chucky' image went viral.
She began undertaking small supporting roles in short film and adverts for companies such as Marks and Spencer and the BBC as well as music videos before undertaking the role of 'Jess' in Molly Crows - the movie ( a part originally written for a 10-14 year old girl) at the tender age of 7yrs old after her original casting video had the director (Ray Andrew Wilkes/Flashgun films) cast her on the spot and after filming finished the director gave her a glowing reference.
I cast Mercy as the lead actor in my most recent film entitled MOLLY CROWS. I was of course skeptical at first given her age (6) and was advised against this by some of my trusted actors and contemporaries. Accordingly I ran a video audition and was surprised by the results. Still not 100% sure I cast Mercy on a trial basis. From thereon Mercy never ceased to amaze us on set. She remembered all her lines and outperformed most of the adult cast (she usually delivered what we needed in one take). Some people say that this is because she's young and has no sense of fear. But I don't buy that - Mercy has demonstrated a complex understanding of human emotion and how to express them in both her actions and speech Furthermore, she has a sublime look on film and a very expressive face.
I would have no hesitation in casting Mercy again and will be very surprised if she is not. an A-List Actor in the future.
Currently Mercy is working on a short cannibal apocalypse movie with filming beginning in February.
Thanks for stopping by. Have a great day and be inspired!


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Many people developing IoT for living. It is getting popular and people want to use IoT Platform to ease their process in building IoT system. The Internet of Things has been hype for couple of years since it began to be recommended by Kevin Ashton on 1999 and started popular through Auto-ID centre in MIT. At this moment, we can see many people is using Internet of Things. Not only in daily life but it begins a university project for their student.
Basically, Internet of Things platform has similar features and basic needs as any other platform to build IoT devices. Some IoT platform providers basic service of a platform. But the main use of IoT Platform is to ease developer/maker to build solution faster by using a platform (IaaS, PaaS, or BaaS) to get lower cost infrastructure.
IoT Platform has became one of regular tools. Most developers will use IoT Platform to develop their product and solution also help them scale up globally. IoT Platform is simply helping engineers to build their Internet of Things project faster and also manage them regularly. This includes building engagement with their user.


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England v Georgia, Rugby World Cup, September 18
History against Georgia
ESPNscrum Staff
September 14, 2011
Jason Robinson slides in to score one of England's 12 tries in the 2003 Rugby World Cup © Getty Images
History suggests that Georgia should be feeling some trepidation as they head into their Pool B clash with Enlgand in Dunedin.
The only previous time the two teams met England obliterated their opponents as they ran in 12 tries in an 84-6 victory in the pool stages of the 2003 Rugby World Cup in Perth. Ben Cohen and Will Greenwood both scored two tries while Neil Back, Lawrence Dallaglio, Dan Luger, Mark Regan, Jason Robinson, Matt Dawson, Steve Thompson and Mike Tindall all touched down. Jonny Wilkinson landed two penalties and five conversions with Paul Grayson slotting four more conversions. The comprehensive victory was England's first match of their ultimately successful Rugby World Cup campaign as they went on to lift the Webb Ellis trophy at Telstra Stadium in Sydney.
However, Georgia are a much improved side and suffered their first international defeat of the year to Scotland in the previous round. Of course their six victories in 2011 have come over smaller nations and their fixture lists over the years largely explains why they have a 62.78% win ratio since their first international game in 1989.
England v Georgia
All-time record: Played: 1, England won 1, Georgia won 0.
Biggest winning margin: Eng: 78 (84-6 Perth 2003)
Highest score: Eng: 84 (84-6 Perth 2003); Geo: 6 (6-84 Perth 2003)
Most tries: Eng: 12 (84-6 Perth 2003)
Most points (individual): Eng: 16 Jonny Wilkinson (Perth 2003); Geo: 3 Malkhaz Urjukashvili and Paliko Jimsheladze (Perth 2003)
Most tries (individual): Eng: 2 Will Greenwood and Ben Cohen
Previous World Cup meetings: One
Statsguru archive:
Click here for England's Test record courtesy of Statsguru
Click here for Georgia's Test record courtesy of Statsguru
Click here for a record of all England v Georgia matches courtesy of Statsguru
© ESPN Sports Media Ltd.
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Business Telephones
A Buyer's Guide
IP business telephones can help small businesses be more efficient, improve existing capabilities, and meet business goals.
Business telephones offer an ever-growing range of features, benefits, and configurations for small businesses. The most advanced business telephones run on Internet Protocol (IP) networks, which many small businesses use to connect employees, devices, and information resources.
How do you choose from all the business telephones currently available? What is the best way to deploy business telephones for your company?
When evaluating and implementing business telephones, you must:
- Understand what your employees need. Business
telephones can give your employees more tools to
be more efficient. Do they need easy access to rich-media
conferencing? Or do they need one phone number that
simultaneously rings on multiple devices?
Business telephones offer many features and capabilities, including:
- Videoconferencing
- Mobile softphones
- Automated attendant
- Paging and intercom
- Presence technology
- Wireless IP capability
- Integration with a customer relationship management (CRM) system
- Unified messaging
- Be prepared for change. Today's business telephones can improve how daily business transactions are conducted. For example, using wireless IP business telephones, your sales floor staff can quickly check if an item is in stock in your warehouse, without ever having to leave a customer's side.
- Talk to your trusted advisor. Consult with your local service provider or reseller to make sure that your business telephones and their features and capabilities will meet your company's short- and long-term business goals.
For more information please visit: Voice and Conferencing


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Latest News
Pakistan may overshadow Afghanistan in Washington talks
WASHINGTON — With nuclear-armed Pakistan increasingly threatened by Islamist militants, President Barack Obama will urge the country's leader on Wednesday to confront the threat head-on, while offering promises of long-term U.S. support, senior U.S. officials said Tuesday.
Obama is simultaneously hosting presidents Asif Ali Zardari of Pakistan and Hamid Karzai of Afghanistan at the White House, but fear for Pakistan's future has now eclipsed the deteriorating situation in Afghanistan and risen to the top of U.S. security concerns.
The administration has called the religious extremists' advances a "mortal threat" to the U.S. and the world. Nevertheless, top administration officials decided at a meeting Saturday to postpone until June 20 a gathering to decide how to implement a U.S. strategy for Pakistan, three U.S. officials told McClatchy, requesting anonymity because of the matter's sensitivity.
In the meantime, Obama and his team are urging Zardari to mount a sustained offensive against the Taliban and its allies, who're imposing a brutal form of Islamic rule across the country's northwest.
Religious militants, who aspire to fundamentalist religious rule like the Taliban maintained in Afghanistan for five years until 2001, took advantage of a cease-fire with the government to win control over the scenic Swat valley and have since moved into neighboring districts, some of which are 60 miles from the capital of Islamabad.
The government began a counteroffensive this week, but Obama aides are skeptical that Zardari's government will persist or that Pakistan's armed forces will overcome their deep-seated reluctance to fight fellow Muslims.
Moreover, as McClatchy reported on Monday, the Pakistani government is using heavy-handed military force in Buner district, flattening villages, killing civilians and creating refugees — steps that could further undermine support for the government.
"All they're doing is displacing civilians and hurting people," said a U.S. defense official who asked not to be further identified because he isn't authorized to speak to the media. "It's not going to work."
U.S. officials emphasize nonetheless that Pakistan must take the fight to the Taliban.
Obama's message to Zardari will be "don't hedge your bets. We're prepared to be your partner for the long term," a senior administration official said.
The key "is for them to not take partial steps, but engage heavily," the senior official said.
"We need to put the most heavy possible pressure on our friends in Pakistan to join us in the fight against the Taliban and its allies," Richard Holbrooke, Obama's special representative for the region, told the House Foreign Affairs Committee. "We cannot succeed in Afghanistan without Pakistan's support and involvement."
Zardari, in an interview on CNN, said his government would take on the Taliban, but he offered no specifics and seemed to hold out hope for the cease-fire, which Washington says has failed. "The cease-fire agreement is not holding. But we are going to try and hold them to it," the Pakistani leader said.
The White House focus on Pakistan is a sharp turnabout from just six weeks ago, when Obama announced a new regional strategy heavily focused on Afghanistan. Additional U.S. troops are due to arrive in Afghanistan next month.
"There's been a shift in focus from Afghanistan-Pakistan to Pakistan in recent weeks," a second senior administration official said. It is "not because we are de-emphasizing Afghanistan," he said. "Quite the contrary. We're asking for more money, we're sending troops, we have dramatically upgraded our embassy."
Yet Obama's efforts to press Pakistan into action could backfire on several fronts.
Zardari's fragile civilian government can't afford the perception that it's doing Washington's bidding. The U.S. has limited leverage over Pakistan and has no plans to send troops into the country.
U.S. officials argue that the events in Swat, Buner and elsewhere have been a wake-up call to the Pakistani government, or at least to the army, the country's strongest institution.
"One of the positive features is a Pakistani desire to in fact fight their own war, that it should be their war . . . . There is always their desire not to be seen to be fighting our war, frankly, which is, again I think it's a good situation," one of the senior officials said.
Finally, Pakistan's elite is suspicious that the U.S. will abandon them at the end of the day, as they think it's done in the past.
Many Pakistanis were infuriated by Secretary of State Hillary Clinton's remarks two weeks ago that the government was "basically abdicating" to the Taliban and allied extremists.
The Obama administration rapidly backed away Tuesday from news reports that it was pushing a "national unity government" in Islamabad between Zardari and the chief opposition leader, former prime minister Nawaz Sharif.
U.S. officials insisted that was never the plan. Rather, they said, Washington is urging Zardari and Sharif, bitter rivals, to set aside their differences, at least on the question of Pakistan's security. "They need to find a way to have a bipartisan strategy, if you will," the first senior official said.
By bringing Zardari and Karzai together — along with legions of their aides — Obama hopes to begin overcoming Afghanistan's and Pakistan's deep mutual suspicions and get the countries to confront an extremist threat that spans their border.
After they visit the State Department, Obama will meet the two men separately, and then host a three-way meeting. The president plans to host such sessions approximately every three months, officials said.
Thousands flee as Taliban take control of Pakistan's Swat
U.S. experts: Pakistan on course to become Islamist state
Pakistani army flattening villages as it battles Taliban
Despite Taliban turmoil, Pakistan expands nuke plants


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The family studies program strongly focuses on integrating theory, research and practice. It encompasses a wide range of family structures, dynamics and functions with an emphasis on the development of interpersonal skills and professional practice. The Family Studies program prepares students for a variety of positions that focus on families or family members at all stages of the life continuum in social service, government and education.
Southeast's family studies program is an accredited Certified Family Life Educator program. The National Council on Family Relations (NCFR) oversees our program, which includes course work that follows the standards and criteria needed for students to become Provisional Certified Family Life Educators. For more information, visit the NCFR website.
Previous Degree Maps


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What Is HIV?
The Human Immunodeficiency Virus (HIV) is a microscopic particle that, once it gets into your body, can make you sick. HIV renders your body susceptible to other infections and illnesses by undermining your immune system.
How Do You Get HIV?
Simply put, you can get HIV through unprotected sex or via other risky activities such as sharing needles for injecting drugs. The virus is transmitted from person to person through contaminated fluids, notably blood, sexual bodily fluids (including vaginal secretions, pre-ejaculate, and ejaculate), and breast milk. Certain factors increase the risk of infection, including actively having a sexually transmitted infection (such as herpes or syphilis), the amount of HIV present in the contaminated fluid, and the length of time of exposure.
How Do You NOT Get HIV?
Tears, saliva, and intact skin are not capable of transmitting the virus from one person to another. The contaminated fluid needs to gain access into the body, typically through a mucous membrane (such as the rectum or vagina) or directly into the bloodstream (such as by sharing needles).
How Do I Know If I Have HIV?
There is only one way to know if you have HIV: get an HIV test. While some people exhibit symptoms shortly after being infected (usually described as flu-like), many people stay infected for ten years or more without being symptomatic in any way.
If I Have HIV, How Long Will I Live?
Thanks to a variety of medicines available to infected individuals, HIV-positive people can expect to live almost as long as their HIV-negative peers. Living with HIV involves taking your HIV medicines property in order to keep your CD4 count up and your viral load down, as well as living a generally healthy lifestyle.
How Many People Have HIV?
HIV has a worldwide distribution with an estimated 34 million people currently living with the infection. HIV affects everyone regardless of gender, race, sexual orientation, or socioeconomic status. Despite public health initiatives, new infections continue to occur, and no cure has been discovered yet. The field of HIV medicine is vast and continues to evolve, but there is much known about its life cycle and ways to prevent its spread.
OK Really: How Does HIV Work?
HIV is in the family of viruses called Retrovirus. Its genetic information is in the form of RNA instead of DNA. In order for HIV to infect human cells and cause destruction, the HIV RNA must be transformed into DNA. It can do this with the help of an enzyme called reverse transcriptase (RT). Without this enzyme, the HIV cannot make new copies of itself. HIV looks like a ball with an inner core, which contains the RNA and the necessary enzymes that we do not have in our cells. The virus is not "alive" per se; it requires the resources of our cells in order to replicate (make more of itself). If the virus cannot penetrate into our cells, then it cannot survive. It would continue circulating around our body trying to find a way to make more copies, but ultimately our immune system would take care of it.
Once HIV enters into the body, it has to dock onto one of our cells to actually cause infection. The HIV docking is specific, notably to cells that contain a complementary receptor called CD4. There are different types of cells that contain CD4, including a part of your immune system called helper T-cells. These cells act like whistleblowers, calling in the heavy-duty cells of your immune system in order to attack foreign invaders and control infection. HIV enters into the cells and then, once in the form of DNA, integrates into the DNA of our cells. It then hijacks the cell and forces it to become a factory designed to produce new HIV particles. Through several biological processes, new HIV copies are made and are then released into the bloodstream allowing the ability for new CD4 cells to become infected. This cycle ultimately kills the CD4 cells.
Every day, millions of CD4 cells in the body are destroyed, releasing billions of HIV particles into the bloodstream; however, your body is hard at work making millions more new CD4 cells which aid in destroying billions of HIV particles. Soon after initial infection, this back-and-forth process of killing and making new CD4 cells and virus can cause acute symptoms, similar to having a bad flu-like illness. This can last days to weeks before a balance is struck between destruction and regeneration. This seesaw battle can persist for years, and it typically is not associated with any symptoms such as fever, fatigue, or weight loss. Over time, though, the body cannot keep pace with replenishing the CD4 cells, and the numbers continue to decrease. As a result, the number of HIV particles increases. This imbalance continues, favoring the HIV, until there is so much destruction of the immune system that it can no longer fight off certain infections like it used to. These infections now have the opportunity to cause disease because the weakened immune system cannot control them. These are called opportunistic infections, and they serve as a hallmark of severe immunodeficiency, or AIDS (Acquired Immune Deficiency Syndrome). Without intervention or treatment, the body will succumb to the overwhelming infection.
The virus is rather careless when it is trying to make copies of itself, and it often makes mistakes (mutations). Sometimes, the mutations are self-destructive, thereby preventing further replication. Other times, the mistakes may be fortuitous, rendering the virus resistant to certain medications. The more resistant mutations that are present, the fewer medications that can be used to treat the virus.
Not all immune systems work the same. Some people may have a genetic alteration in their CD4 dock; consequently, it will be more difficult for HIV to penetrate into these cells. If the virus cannot enter the cell, then it cannot replicate. These individuals tend to have a slower course of infection, and often can be found to have a stable immune system for decades. Certain factors can impact negatively on the immune system, including substance use (e.g., crystal meth), poor nutrition, steroid use, and other infections or illnesses (e.g., Hepatitis or cancer). This could cause a more rapid course of decline, with symptoms and opportunistic infections appearing earlier.


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Facial atrophy, which can give patients being treated with AIDS drugs a gaunt appearance, can be successfully treated with injections of solution containing polymethylmethacrylate (PMMA), a type of bone cement, Dr. M.S. Serra announced at the 15th International AIDS Conference in Bangkok.
The Rio de Janeiro-based doctor presented five-year follow-up data for 441 men and 63 women who underwent the procedure, which can be performed on an outpatient basis. Serra said the procedure was "demonstrated to be long-lasting, easy to be performed and safe."
In the study, a solution containing PMMA and a local anesthetic was injected into atrophic areas on the face. Patients were followed at six-month intervals for up to five years and were photographed before and after the procedure. Study patients reported high levels of satisfaction with the procedure and improved quality of life. Serra noted there were no unexpected side effects related to the procedure and no effects on the patients' immune cells.
"This is not a cosmetic procedure," said Serra. "It is corrective surgery," that should be available to all patients who develop facial wasting as a result of anti-HIV therapy. A full-face treatment, which requires two sessions, costs about $500, he added. Serra is currently working with the Brazilian government to provide the procedure for free for patients undergoing AIDS treatment.


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BLUE Wilderness® Chicken For Large Breed Adult Dogs
Inspired by the diet of wolves, true omnivores whose endurance is legendary, BLUE Wilderness is a grain-free, protein-rich food that contains more of the delicious chicken your dog loves.
Made with the finest natural ingredients – and no grains.
- Deboned chicken, chicken meal and fish meal supply the protein your dog needs
- Sweet potatoes, peas and potatoes provide healthy complex carbohydrates
- Blueberries, cranberries and carrots support antioxidant-enrichment
And to support the special needs of bigger dogs, BLUE Wilderness for Large Breed Dogs is formulated with glucosamine and chondroitin to help promote joint health.Available in 24-lb. bags.
Exclusive LifeSource Bits®
BLUE LifeSource Bits are a precise blend of antioxidants, vitamins and minerals selected by holistic veterinarians and animal nutritionists that support:
- Immune system health
- Life stage requirements
- Healthy oxidative balance
And LifeSource Bits are cold-formed to help retain the potency of their ingredients. This means that we minimize the amount of heat that LifeSource Bits are exposed to during the manufacturing process. It's the same concept as when you cook vegetables at high heat — the longer you do, the more heat-sensitive nutrients are lost.
Product Benefits
Joint Health
Glucosamine, Chondroitin, and EPA help support healthy joint function and overall mobility.
Lean Muscle Development
High-quality protein from Deboned Chicken, Chicken Meal and Fish Meal, plus L-Carnitine help develop and maintain lean muscles.
Strong Bones & Teeth
A precise blend of Calcium, Phosphorus and essential vitamins helps promote strong bones and teeth.
Healthy Heart
Taurine is an important amino acid that helps maintain heart health.
Healthy Skin & Coat
An optimal balance of Omega 3 & 6 Fatty Acids helps promote a shiny coat and healthy skin.
Immune System Health
Essential vitamins, chelated minerals and important antioxidants help support the immune system.
ALWAYS Starts with Protein-Rich CHICKEN
- NO Chicken (or Poultry) By-Product Meals
- NO Corn, Wheat or Soy
- NO Artificial Flavors or Preservatives
Guaranteed Analysis
|Crude Protein
|32.0% min
|Crude Fat
|13.0% min
|Crude Fiber
|7.0% max
|10.0% max
|0.1% min
|1.2% min
|0.9% min
|0.1% min
|Omega 3 Fatty Acids*
|0.75% min
|Omega 6 Fatty Acids*
|2.25% min
|100 mg/kg min
|700 mg/kg min
|Chondroitin Sulfate*
|550 mg/kg min
*Not recognized as an essential nutrient by the AAFCO Dog Food Nutrient Profiles.
Nutrition Statement
BLUE Wilderness Nature's Evolutionary Diet with Chicken for Large Breed Dogs is formulated to meet the nutritional levels established by the AAFCO Dog Food Nutrient Profiles for maintenance.
Feeding Guidelines
Calorie Content: 3,487 Kcals/kg, 377 Kcals/cup
*Use a standard 8-oz. measuring cup.
Note: Individual dog's requirements may vary due to age, breed, environment, and activity level. Adjust food as required to maintain optimal body condition, and ask your veterinarian if you are unsure.


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Browse and Buy e-Books from Your Kindle Fire HD
You'll find that reading books on Kindle Fire HD is convenient and economical (e-books are typically a few dollars less than the print version, and you can borrow e-books from your local library for free).
To browse through e-books from Amazon on your Kindle Fire HD, follow these steps:
Tap the Books button on the Kindle Fire HD Home screen.
Tap the Store button.
The Amazon Bookstore sports a Recommended for You section at the top which suggests books for you based on your buying history.
Swipe right to left to scroll through the recommendations at the top.
You also see categories such as Kindle Select 25, Best Sellers, and Editor's Picks.
As with the Newsstand, when you locate and tap an item in the bookstore you see a screen with that item's pricing and description. In the bookstore, the buttons you see at this point are labeled Try a Sample, Add to Wish List, and Buy (or Buy for Free).
Here's how these three buttons work:
Try a Sample: Tap this button, and it changes to a Downloading button, and then to a Read Now button. Tap the Read Now button to open the sample of the book.
Add to Wish List: Tap to add the selection to your Wish List. You can view your Wish List at any time by tapping the Menu button on the Options bar and tapping Wish List.
Buy or Buy for Free: Tap this button, and it changes to a Downloading button. When the download is complete, the button label changes to Read Now. Tap the Read Now button to open the book. Remember that the book is now stored in your Books library, where you can tap it to open and read it at your leisure.
After you've read a bit of your new book, it will appear both in your Books library and on the Carousel on the Home screen.
To remove a book from your device (remembering that it will still be stored in the Amazon Cloud), open your Book library, press and hold the book, and tap Remove from Device from the menu that appears.


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Liaison - Palm Tree
Liaison - Palm Tree
100% Polyester
Acrylic Backing with NanoSphere®
60,000 Double Rubs (cotton duck)
11.5 ounces per linear yard
7" H x 6-7/16" V (Pattern is woven up the roll and suitable for railroading)
Liaison is part of the Suite Life Collection. For more information about specifications and available colors, click here to download the Suite Life sample card.
Request Sample


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Despite loss, Bergman has debut to remember
DENVER -- Right-hander Christian Bergman has little to regret about his Major League debut, except perhaps that his was one of only three hits the Rockies could muster against Braves right-hander Gavin Floyd.
Outfielder Corey Dickerson homered in the eighth, otherwise Braves pitchers fooled Rockies batters all evening to secure a 3-1 victory in the series opener at Coors Field on Monday.View Full Game Coverage
DENVER -- Right-hander Christian Bergman has little to regret about his Major League debut, except perhaps that his was one of only three hits the Rockies could muster against Braves right-hander Gavin Floyd.
Outfielder Corey Dickerson homered in the eighth, otherwise Braves pitchers fooled Rockies batters all evening to secure a 3-1 victory in the series opener at Coors Field on Monday.View Full Game Coverage
"I felt like Bergman was outstanding," said manager Walt Weiss. "He certainly pitched well enough to win, but we got shut down by Floyd."
Bergman (0-1) began his Major League career by tossing three no-hit innings before outfielder B.J. Upton broke through with a swinging bunt single to start the fourth. After stealing second, Upton scored on a groundout by catcher Evan Gattis. The Braves added a run on a two-out single from third baseman Chris Johnson.
"That inning, I think there was one ball hit hard," said Bergman. "It's hard to find any fault in that. Maybe you throw a different pitch, but it's easy to look back and say that."
The Braves got to Bergman for three more hits after that, but none for extra bases.
"He knows how to pitch off the barrel," said Weiss. "He makes the ball move late and makes it tough on hitters."
Bergman, a former 24th-round pick, refused to be rattled through the six innings he pitched, dancing around the damage while striking out four. But it was the damage that has already been done to the Rockies' lineup that proved to be the difference.
On a day when Michael Cuddyer's fractured right shoulder socket and Carlos Gonzalez's scheduled exploratory finger surgery were announced, the Rockies' offense looked lifeless, with four hits.
"You look at the guys that are out … [Gonzalez], a former All-Star left fielder; a former All-Star right fielder [in myself]; and [Nolan Arenado], a guy who was probably going to be an All-Star third baseman," said Cuddyer. "There's no question that's tough, but at the same time, nobody in the league is going to feel sorry for us."
Rather than wallow, Weiss chose to credit Floyd (1-2).
"What made [Floyd] tough was his slider," said Weiss. "He pitched well with his fastball away, particularly to our right-handed hitters and [left] very little in the middle of the plate."
Floyd had only made one previous start in Coors Field in his 11-year career. Although he wasn't fazed by the altitude in that 2011 outing, his seven-inning, two-run performance couldn't secure the victory. This time around he had little trouble earning his first win of the season.
"When you pitch and you get ahead of hitters, it doesn't matter where you pitch -- you're going to have low-scoring games," said Braves manager Fredi Gonzalez.
Though his young hurler had only thrown 89 pitches, Weiss decided to play it safe and brought in right-hander Rex Brothers after Bergman worked his way out of a bases-loaded jam to end the sixth.
Following the loss, Weiss said he felt that Bergman was capable of going back out but saw little else for him to accomplish.
"At that point I felt like he did his job," he said. "I felt like it was good for him to finish on a positive note, so that's why I went to Rex."
Brothers, too, had a positive note. The hard-throwing reliever entered the game having allowed 10 earned runs over his previous seven appearances, but he shut down the Braves in his inning of work, striking out three and walking one.
"I saw some depth to his slider and some angle to his fastball," said Weiss. "I know he's been working on some minor things mechanically, but it looks like it paid off tonight."
The Rockies' best chance to strike came in the seventh. Dickerson sent a 2-1 pitch into the left-field bleachers to lead off the inning, but Floyd settled down for two quick outs before walking second baseman DJ LeMahieu.
After that free pass ended Floyd's night, pinch-hitter Brandon Barnes welcomed left-handed reliever Luis Avilan with a ground ball up the middle and hustled into second for a double. Yet with runners on second and third, outfielder Charlie Blackmon grounded out softly to Avilan to kill the rally. Right-handers Shae Simmons and Craig Kimbrel took it from there and closed it out for the Braves.
The Rockies have now lost 10 of their last 11 and 14 of 17 dating back to the start of their previous road trip.
Cody Ulm is an associate reporter for MLB.com.


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On last night's episode of T&T, there was a lot of bad blood between two moms whose young daughters (Gabby and Alaska) often compete in the same age division of the same pageants. On camera, they repeatedly made barbed comments each other—about Alaska's mom's missing teeth, bitchy judgement about the color of a Gabby's dress, etc. Alaska's mom even accused the Gabby's mom of stalking her and Alaska in an effort to rip off her daughter's routine. But it was what happened behind the scenes that got the pageant director involved in their feud. Apparently they were involved in some kind of drama on Facebook, saying negative things about each other. Aren't they too busy gluing rhinestones onto costumes, dying their daughters' eyelashes and living vicariously through their children to have enough time for this nonsense?
Pageant Moms Chided for Inane Facebook Feud


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The amniotic sac, or amnion, is a lining (membrane) inside the
uterus that contains the fetus and the fluid that cushions the fetus (amniotic
fluid). The amniotic sac is also called the "bag of waters."
Last Revised:
January 8, 2013
Healthwise Staff
Medical Review:
Sarah Marshall, MD - Family Medicine & William Gilbert, MD - Maternal and Fetal Medicine
This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.
To learn more visit Healthwise.org
© 1995-2012 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.


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- Chifley Sports Reserve (Previously: Womens Athletic Field), Chifley, NSW 2036
- 10-20 km from Rose Bay
T-Ball Activities for Kids - Rose Bay (2029)
Best match results for t-ball activities for kids in Rose Bay + 30km.
The not-for-profit club offers Aussie T ball and baseball for junior players over summer aged from 6 years old to 16 years old. Over winter the club offers senior/adult baseball.
Welcome to Castle Hill Softball Club (CHSC)! We are an incorporated Softball and Tee-Ball club that plays under the Cumberland Nepean Softball Association (CNSA), and have teams compete in their summer competitions (October to March). In 2019, we are celebrating over 45 years of Softball and Tee-Ball in the Hills District! CHSC caters for players of all ages and abilities! Junior players can start in the Blast Ball and Tee-Ball competition as early as 3 years of age, and live-pitch Modball and ... Read more Softball can be played from the age of 10. For our Senior players, there are graded competitions for Ladies and Men, as well as Mixed Division competitions. Ladies and Mixed Division teams play on a Saturday at either Stanhope Gardens Softball Fields or International Peace Park (IPP) in Seven Hills, and the Men's and Ladies Over 35's divisions play on Friday and Wednesday nights respectively at Stanhope Gardens. If you are looking for some friendly competition and fun in the sun, then we would ...
AMAZING club!
16-08-2019 by Michelle
My daughter and I have been playing at Castle Hill Softball Club for the last 15 years, and we couldn't have picked a better club to join all those years ago! Fun and friendly atmosphere, training and teams to cater for everyone, and great team and club spirit. Could not recommend more!
We are Sports Camps Australia and we offer our camps in every school holiday. Our camps are running in Sydney, regional NSW, Queensland, Victoria and Western Australia. We have a dedicated team of camp directors all well known in their particular sport who are passionate about teaching your kids to be the best they can be in their favourite sports and making friends along the way. Please contact us so we can find the closest camp for you.
Junior Baseball Club located in the Manly Warringah District playing throughout the area and Sydney wide. Cater for all ages and abilities from 4-104yrs. Aussie Tee Ball, Tee Ball, Junior Baseball & Senior Baseball.
Well established Baseball & Softball Club, catering for children from 4 yrs old to adults, men and women over 60 yrs old. Established in 1977, Stealers continues to provide Great facilities for Great members in a Great Club. Why not play ball, either Tball, Baseball or Softball with us and you can be a part of the Stealers family. Celebrating over 40 years of playing ball
The Five Dock Falcons Baseball Club is a family oriented baseball club located in the inner western suburbs of Sydney. From T-ball through to Seniors, both men and women, we promote a friendly, family oriented baseball club. The Falcons cater for all level of player from beginner to A Grade.
We are a non-for-profit junior baseball club, catering for kids aged 5 to 16. We pride ourselves on providing a positive and nurturing environing for all kids wanting to be part of this fun-filled sport, regardless of background or natural sporting ability. Please visit our website or give us a call for more information.
Other related businesses in and around Rose Bay (within 50km)
Local club running in Seven Hills Toongabbie area.
Club Values
25-10-2015 by T'sMum
This Club is KEEN. Expansion is their drive, playing baseball is their passion. Good sportsmanship is the primary drive of the Club and enjoying the game brings enormous satisfaction to all Players and Visiting Teams. If you want to play the game, enjoy yourself and enjoy affordable Registration Fees, this is the Club for you!
We are a new family friendly club joining the Central Coast Softball Association for the upcoming 2018/19 season summer. Based on the Woy Woy Peninsula we are looking for players male and female from 5yrs to 65+. Any skill level from beginner to experienced, there is a team for you. Training is based at Woy Woy whilst ALL games are played at Bateau Bay Sports Field, Passage Rd, Bateau Bay. All junior games are played Saturday morning with senior games in the afternoon. Our season runs from ... Read more October to March with a break over the Christmas school holidays. If you're looking for a new sport why not give softball a try. We are an approved active kids voucher provider. We look forward to seeing you on the diamond this season.


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Plenty of prominent places have new faces in the coaching position as we head into the summer, including Texas, USC, Penn State and Washington, and it wouldn't be surprising to see more big-name programs join the list by the end of December. Coaches might be used to getting at least a full recruiting cycle to prove themselves, but with patience at an all-time low now in the sport, athletic directors can be quick to pull the trigger.
After disappointing seasons, coaches like Will Muschamp and Brady Hoke got the opportunity to make high-profile assistant coaching changes at the end of last year, but the blame can only be placed elsewhere for so long. Here are the head coaches who are under the most pressure in 2014.
Must Win Now
Will Muschamp, Florida. Ron Zook went 23-14 in his three seasons. Will Muschamp so far has gone 22-16. Zook unsuccessfully bridged the gap from Steve Spurrier to Urban Meyer, and Muschamp has struggled to come anywhere near the heights Meyer achieved. Both Spurrier and Meyer were revolutionary offensive coaches; Muschamp, a great defensive coordinator, has presided over offenses that ranked sixth, 12th and 14th in the SEC in yards per play. To be fair, Florida couldn't have suffered from worse injury luck last year, but the downward trend is still troubling. Florida fell from the Sugar Bowl to 4-8 -- its first losing record since 1979 -- and a loss to an FCS team, Georgia Southern, that had zero passing yards. The offense felt aimless and helpless, and that's especially unacceptable at a program that has peaked under two offensive innovators.
Muschamp now appears to be moving away from his ultra-conservative philosophy, hiring Kurt Roper to install a more modern, uptempo, spread offense, after Roper achieved nearly unprecedented success with the respected David Cutcliffe at Duke. Anchored by Dante Fowler and Vernon Hargreaves, Muschamp's defense should again find success, and it's simply a matter of the offense becoming competent enough to sustain drives without shooting itself in the foot repeatedly. Quarterback Jeff Driskel, who's been uneven and turnover-prone, is healthy again (with star recruit Will Grier waiting behind him should he falter), but the receiving corps has really struggled lately. Running back Kelvin Taylor -- the son of Fred Taylor -- might be poised to break out as a sophomore. Now on his third offensive coordinator in four years, Muschamp needs his offense to show signs of life. Even doubling the win total to eight may not be enough.
Mike London, Virginia. Despite going winless in the ACC and finishing 2-10 last year, London -- a man of few words, it seems -- still managed to sign a respectable recruiting class, but there's been little else to be happy about, and it's hard to imagine London actually guiding this class through their entire college careers. London is 18-31 in five seasons in Charlottesville, his one bowl appearance coming in an 8-5 season in 2011, and his record looks even worse given his high-priced assistants, including defensive coordinator Jon Tenuta and two former FBS head coaches. He's won a total of two conference games since that bowl appearance, while also losing to Louisiana Tech and Ball State. With that 48-27 home loss to Ball State last year, it seemed as if Virginia would be better off not letting Cardinals coach Pete Lembo leave campus without agreeing to replace London. Virginia seems like the only team that doesn't have even an outside shot at winning the wide-open ACC Coastal, and with UCLA, BYU, Florida State and Louisville also on the schedule, London will have trouble winning anough to stick around.
Dana Holgorsen, West Virginia. What appeared to be a happy marriage has fallen apart quickly. After the bizarre coach-in-waiting transition that saw Holgorsen get promoted to head coach a season earlier than expected, he began his stint in Morgantown with a 10-3 record and a 70-point outing in the Orange Bowl. His upward trajectory continued into the first half of 2012, when the combination of Geno Smith, Tavon Austin and Stedman Bailey raced out to a 5-0 record under Holgorsen's high-powered offense, including a jaw-dropping 70-63 win over Baylor. But the Mountaineers hit a wall in their Big 12 move in October, dropping six of their last eight games to finish 7-6. Smith's Heisman campaign fell apart rapidly, as did Holgorsen's standing as one of the game's best young coaches.
It only got worse last year, as they finished 4-8 with a revolving door at quarterback, ending the year with consecutive losses to Kansas and Iowa State. Since beating Texas on Oct. 6, 2012, West Virginia has gone 4-12 in Big 12 play. It's been a rough transition to a league where West Virginia is geographically out of place, and while a defensive shake-up -- the promotion of Tony Gibson to coordinator and the addition of longtime Penn State assistant Tom Bradley as associate head coach -- could help a unit that gave up 33 points per game, this season could get ugly in a hurry. The Mountaineers open with Alabama, visit a Maryland team that collbered them 37-0 last year and host Big 12 favorite Oklahoma -- all before the end of September. Holgorsen is a great offensive mind, but he has a whole lot to prove as a CEO.
Charlie Weis, Kansas. Weis has gone 4-20 in two years at Kansas, after going 16-21 in his final three years at Notre Dame. Nobody said winning in Lawrence was easy, but Weis' brash personality doesn't give him much margin for error. Two of his four wins have come against South Dakota State and South Dakota; one of the others was an unwatchable 13-10 win over Louisiana Tech. So, thus far, the only thing Weis can cling to is last November's 31-19 win over floundering West Virginia, which was followed by a 34-0 loss to Iowa State and a 31-10 loss to Kansas State. Weis has bet big on juco players (although not as many in 2014), following the model of in-state rival Bill Snyder, but so far it's not working. Now, Kansas leaves spring ball with the only talk being rumors about the possible transfer of quarterback Jake Heaps. Weis struggled to develop recruits at Notre Dame and has always felt like a better fit for the pro game. Thus far, all the reservations about his getting the Kansas job have borne out.
Tim Beckman, Illinois. One of the most bizarre occurrences in recent college football history has to be Illinois' appearance in the Rose Bowl in the 2007 season. The Fighting Illini didn't win the Big Ten and finished 9-3, but they got a bid to Pasadena anyway, because of the Rose Bowl's insistence on inviting a Big Ten replacement for Ohio State, who played for the national title. It was Illinois' first bowl bid since 2001, as Ron Zook had gone 4-19 in his first two seasons, and he then went 21-28 over the next four years before getting fired. Beckman has gone 6-18 in two years, with only one of those wins coming in Big Ten play, against hapless Purdue last November. He did double his win total last year, at least, as the offense found renewed life thanks to the inspired hire of coordinator Bill Cubit, but confidence is not exactly high in Champaign. Beckman might need to get to bowl eligibility to save his job, which probably will require winning three conference games. Good luck finding them on the schedule.
Kyle Flood, Rutgers. Just about every piece of Rutgers football news since the Big Ten invitation came has been bad. Flood has passed the time quietly and comes very cheap, by Big Ten standards, but any momentum that Greg Schiano had built up has petered out by now. Sure, the Scarlet Knights now have a stable place in the FBS hierarchy with a spot in the lucrative Big Ten, but last year, they finished 6-7 in the American Athletic Conference, were held under 20 points in five of eight league games, threw 22 interceptions and struggled on the recruiting trail. The once-stingy defense has also taken a big step back, and Flood has a pair of new lieutenants: former Maryland coach Ralph Friedgen as the offensive coordinator, and the promoted Joe Rossi on defense. The Big Ten has been down, sure, meaning there is room to move up in the league, but the Scarlet Knights are heading in the wrong direction when joining a division with Ohio State, Penn State, Michigan and Michigan State. With coaches like Urban Meyer, James Franklin and Brian Kelly capable of invading New Jersey, Rutgers may need to find a young, energetic recruiter to try to keep pace in the Big Ten East.
How Long Can It Last?
Bo Pelini, Nebraska. Pelini could be fired tomorrow or last another 10 years, for all we know. He's lost exactly four games in each of his six seasons, which is hardly unforgivable but not quite up to the lofty standards of Nebraska football. From a recording of a rant about Nebraska's fans to his recent cat diplomacy to his fiery temper, Pelini has always been in the news, even if it's not for actually winning many big games. January's Gator Bowl win over shorthanded Georgia was nice, but it came after a home embarrassment against Iowa. There's always bad news with the good news. Aside from the presence of running back Ameer Abdullah and defensive tackle Randy Gregory, two All-America candidates, Nebraska just hasn't been able to do anything particularly great as it sort of treads water as a back-of-the-top-25 team. Combined with the personality clashes, it's not hard to wonder how long all parties involved -- fans, administrators, players, Pelini -- will be satisfied with the arrangement.
Paul Johnson, Georgia Tech. Old-school option football is losing its luster. Johnson won ACC coach of the year his first two years on the job after leaving Navy, but there's a sense of restlessness now, after back-to-back seven-win seasons in a mediocre ACC Coastal. Johnson denied reports that he's unhappy with the school, but combined with the transfer of quarterback Vad Lee and losses in the final three games against FBS opponents -- including a 12th loss in 13 tries against Georgia -- there hasn't been much to be happy about. If Justin Thomas emerges as a legitimate threat at quarterback, Georgia Tech could compete for the Coastal title, but if the Yellow Jackets tread water again around .500, all involved may be ready for a change.
At a Crossroads
Brady Hoke, Michigan. Barring disaster, I'm not convinced it will happen in 2014. Still recovering from the poor match with Rich Rodriguez, Michigan can cling proudly to its Michigan Man, who's a good cultural fit, a good recruiter and a good defensive coach. Obviously, though, something has to change after last year's painfully inconsistent season, which included near-disasters against Akron and UConn, a 27-carries-for-27-yards performance from the starting running back in a loss to Penn State, 2.8 sacks allowed per game, 3.28 yards per rush attempt and a 7-6 final record after starting 5-0. The interior of the offensive line was a disaster, magnifying quarterback Devin Gardner's weak decision making, and the whole old-school, power-offense philosophy can't work if the offensive line struggles so much. As expected in such a situation, the blame was placed on offensive coordinator Al Borges, who was pushed out to make room for Doug Nussmeier, formerly at Alabama. Hoke initially took Michigan from 7-6 to 11-2, but now the program has gone back to 7-6. Hoke has to start closing the gap with Ohio State -- and Michigan State, for that matter -- sooner rather than later. It doesn't help that the Wolverines must go on the road to both places, plus Notre Dame, this fall.
Randy Edsall, Maryland. All you can ask for is progress. Edsall's tenure in place of Ralph Friedgen got off to a disastrous start, with a rash of transfers combined with a 2-10 record. But Maryland has gotten better each year, and it's done so despite ridiculously bad injury luck that saw freshman linebacker Shawn Petty play quarterback in 2012 (4-8 record) and arguably the team's two best players, receivers Stefon Diggs and Deon Long, both miss the second half of the 2013 season (7-6 record with a Military Bowl loss to Marshall). It's not like Maryland faces a huge step up in competition, entering the Big Ten East from a division that included Florida State and Clemson, but Edsall still has to prove that he can protect his recruiting turf in a division that includes Urban Meyer and former Terrapins coach-in-waiting James Franklin.
Kyle Whittingham, Utah It's hard to find fault with a guy who's gone 76-39 in nine seasons since replacing Urban Meyer, including the landmark Sugar Bowl win over Alabama in the 2008 season. But Whittingham is in a tough spot, trying to establish Utah's place in the Pac-12 after making the transition from the Mountain West, where the Utes were powers. The new conference experience got off to a solid start, with an 8-5 record in 2011, but the last two years have seen the Utes go 5-7 and miss bowl games for the first time since 2002, before Meyer arrived. To their credit, the Utes took down Pac-12 champion Stanford last year, but otherwise, they have a lot to prove in what's becoming an increasingly difficult Pac-12 South division. While Whittingham isn't in immediate danger given all he's accomplished at Utah, throw in a recruiting class that Rivals.com ranked 67th, and he's facing a season in which he needs to start reversing this downward trend before it becomes impossible to dig out.
Dan Mullen, Mississippi State. Mullen's in a tough situation and probably shouldn't be on this list. It's not impossible to compete in Starkville, but this also isn't anywhere close to a premier SEC job. The Bulldogs reside in the middle of a good recruiting area, but there are so many programs surrounding them that are competing for the same recruits with better resources and more prestigious histories. Since starting at 5-7 in 2009, Mullen has taken the Bulldogs to four straight bowl games, although he's yet to return to the 9-4 standard he set in 2010 -- a season that may have unfairly altered expectations. Maybe it was too much, too fast. Mississippi State is starting to get traction as a sleeper this year, though, and it makes sense: Dak Prescott appears to finally be the perfect fit for the offense of Mullen, an Urban Meyer protégé, and while no SEC West schedule is easy, their nonconference slate is a cakewalk, and they draw Vanderbilt and Kentucky in cross-division games. It's not often that Mississippi State can coast to seven wins, so Mullen needs to capitalize as expectations creep higher. If ever he's going to repeat 2010 or even better, this is the year. A disappointing season could change things in a hurry, even if expectations are out of whack with what should reasonably be expected.
The Kirk Ferentz Category
Kirk Ferentz, Iowa. He's kind of obligated to be mentioned at this point, and sometimes it feels like we'll be talking about his buyout until about 2050. He's essentially the Bobby Bonilla of college football, with Iowa destined to pay him forever. According to USA TODAY Sports, Ferentz made nearly $4 million last year, but with that hefty price tag has come just one 10-win season since 2004. The good news is that Ferentz engineered a solid rebound year in 2013, going from 4-8 to 8-5, and with a solid quarterback in Jake Rudock, a fairly deep cast of skill position talent and one of the league's easiest schedules, it's hard to see Iowa falling far enough to warrant even consideration of a move, given his pricey buyout. In fact, the Hawkeyes may be good enough and have a clear enough road to contend for the Big Ten West title. The problem with Ferentz, as always, is that his punt-to-win offense causes fans to lose patience much more quickly when expectations are not met. Nobody wants to be bored, especially at that price.
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Contact me at firstname.lastname@example.com and follow me on Twitter @MattBrownSoE.


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Viewing Your Tasks in Outlook 2007
Outlook 2007 comes with several ways to view your Tasks list and enables you to invent and save as many custom views as you like. The views that come with Outlook take you a long way when you know how to use them.
To change your view of your tasks, choose View–>Current View, and then choose one of the following views from the menu:
- Simple List view presents just the facts — the names you gave each task and the due date you assigned (if you assigned one). The Simple List view makes it easy to add new tasks and mark old ones complete. However, you won't see any extra information. If you want
details. . . .
- Detailed List view is a little more . . . uh, detailed than the Simple List view. It's really the same information, plus the status of the tasks, the percentage of each task complete, and whatever categories you may have assigned to your tasks.
- Active List view shows you only tasks that you haven't finished yet. After you mark a task complete, zap! Completed tasks vanish from the Active List view, which helps keep you focused on the tasks remaining to be done.
- Next Seven Days view is even more focused than the Active List view. The Next Seven Days view shows only uncompleted tasks scheduled to be done within the next seven days. It's just right for those people who like to live in the moment, or at least within the week.
- Overdue Tasks view means that you've been naughty. These are the tasks that needed doing yesterday but are still hanging around today.
- By Category view breaks up your tasks according to the category that you've assigned each task. You can open and close categories to focus on the type of tasks you're looking for. For example, you may assign a category of Sales to the sales-related tasks in your list. When you want to focus on sales, use the By Category view and click the Sales category.
- Assignment view lists your tasks in order of the name of the person upon whom you dumped, er, delegated, each task.
- By Person Responsible view contains the same information as the Assignment view, but the list is grouped to let you see the assignments of only one person at a time.
- Completed Tasks view shows (you guessed it) tasks you've marked complete. You don't need to deal with completed tasks anymore, but looking at the list gives you a warm, fuzzy feeling, doesn't it?
- Task Timeline view draws a picture of when each task is scheduled to start and end. Seeing a picture of your tasks gives you a better idea of how to fit work into your schedule sensibly.
- To-Do List view includes all the tasks you've entered, as well as any flagged e-mails that show up in the To-Do Bar. The other Tasks List views show only the items you've added directly to the Tasks List.


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Inspiration 101: "How I Wrote..."/
I just stumbled across The Guardian's live music series "How I Wrote..." where musicians tell of the inspiration behind their top songs -- and then perform them live in the studio. It's quite a find and worthy of burning off at least an hour today. From Cee Lo Green, British Sea Power, Warpaint, Antony & The Johnsons, to Rufus Wainwright and Corinne Bailey Rae. It's quite a collection.
You can follow them on Twitter to get the latest updates of course..


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A former Deutsche Bank and movie executive lost a $20 million lawsuit Friday accusing Los Angeles police officers of beating him up in 2012.
A jury returned the verdict after hearing testimony from Brian Mulligan and the two officers who said they restrained but did not beat him. Mulligan acknowledged using a drug known as bath salts in the weeks leading up to the incident.
Mulligan said he was driven to the drug to deal with sleeping problems but denied the substance made him paranoid during the May 2012 confrontation with officers.
The officers painted a portrait of an uncontrollable man frothing at the mouth. They denied beating him with batons.
Second Arrest Made, Third Woman Sought in Deadly Nightclub Beating
"This guy had gone crazy," Officer John Miller testified during the trial. "He'd lost his marbles. I was a bit scared. I'd never seen anybody frothing at the mouth and growling as an adult human being."
He and Officer James Nichols took the stand after lengthy testimony from Mulligan, whose excessive-force suit claims he suffered a broken nose and shoulder and other injuries along with mental torture from an unprovoked beating.
The one-time Deutsche Bank official said he had used the drug at least 20 times -- but not on the night of the encounter.
Nichols, however, said Mulligan told him he had taken a type of bath salts called "White Lightning" four days earlier and hadn't slept since. He painted a portrait of a delusional man who was spotted wandering the street with wads of crumpled $100 bills falling out of his pockets.
SUV Driver Strikes Five Family Members Near School
The case played out against a backdrop of horrifying photos of Mulligan's smashed nose and face. He said he suffered multiple fractures of the nose and lost his sense of smell. He said he still suffers panic and flashbacks to the incident. An expert witness testified the injuries clearly were inflicted by a baton.
Mulligan lost his job with the bank over the incident that was highly publicized. He also had been co-chairman of Universal Pictures and chief financial officer with Seagrams Co.
"Now is not the time to comment on the trial process," Mulligan said in a statement after the verdict was read. "I just want to thank family, friends, and the business community for their support."
A civilian oversight board found the officers' use of force to be appropriate, and a claim against the city over his lost bank job was dismissed.