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The Chinese Communist Party (CCP) yesterday began a key meeting to dictate the direction of the world's second-biggest economy for the next decade.
Xinhua news agency said the gathering of the party's Central Committee would discuss a draft document on "major issues concerning comprehensively deepening reforms" in the Chinese economy, a key driver of regional and global growth.
The meeting, which is known as the Third Plenum and takes place amid intense security and secrecy, has traditionally set the economic tone for a new government, and past meetings have been used to signal far-reaching changes
Recent reports in party and state media have singled out key issues at the four-day meeting as potentially including land and administrative reforms, as well as reducing protections for powerful state-owned enterprises.
A government think tank called for dismantling the residency registration system known as hukou, which restricts access to medical insurance and other benefits for migrants. China also faces other important issues, including oppressive air and environmental pollution, and how to retool its economy to ensure more sustainable growth.
The meeting comes a year after China embarked on a once-a-decade leadership transition, with Chinese President Xi Jinping (習近平) taking over as party general secretary before becoming president in March.
Although the economy is no longer completely party and state-controlled, the CCP holds huge sway, with officials in charge of key elements, such as the exchange rate, that in other countries are left mostly to markets.
Xinhua said the party's draft document "pools the wisdom of the whole party and from all aspects" and is expected "to advance the reform that has lasted for more than three decades."
China's leadership recognizes that the country's economic growth model, largely based on state-financed investment, needs to give way to one in which consumers and other private actors take the lead in propelling expansion.
However, changing direction is no easy task given entrenched interests and ways, as well as the economy's increasing complexity.
The Global Times newspaper, which has close links to the party, alluded to such challenges in an editorial.
"Different groups in society have different — or even conflicting — interests," it said.
Analysts say broad brushstrokes rather than firm details are more likely to emerge from the meeting after it concludes on Tuesday.
"Expectations are not very high for the economic reform blueprint which will be spelt out at the plenum," said Willy Lam (林和立), an expert in Chinese politics at the Chinese University of Hong Kong.
"This is because Xi Jinping has emphasized the values of stability and also incremental changes," he said.
China most notably signaled major reforms at a Third Plenum in 1978, when it embarked on the landmark drive that has seen it transformed over the past three decades from a communist-style command economy into a key driver of global growth, trade and investment.
However, "intellectuals in Beijing are not very optimistic that the reforms introduced at the weekend will be as forward-looking and sweeping as those introduced by [late Chinese leader] Deng Xiaoping (鄧小平) 35 years ago," Lam said.
The People's Daily newspaper, the official party mouthpiece, firmly rejected any Western-style political reforms on the eve of the gathering.


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Nazi Germany and the Jews, 1933-1945 is an abridged edition of Saul FriedlAnder's definitive Pulitzer Prize-winning two-volume history of the Holocaust: Nazi Germany and the Jews: The Years of Persecution, 1933-1939 and The Years of Extermination: Nazi Germany and the Jews, 1939-1945. The book's first part, dealing with the National Socialist campaign of oppression, restores the voices of Jews who were engulfed in an increasingly horrifying reality following the Nazi accession to power. FriedlAnder also provides the accounts of the persecutors themselves-and, perhaps most telling of all, the testimonies of ordinary German citizens who, in general, stood silent and unmoved by the increasing waves of segregation, humiliation, impoverishment, and violence. The second part covers the German extermination policies that resulted in the murder of six million European Jews-an official program that depended upon the cooperation of local authorities and police departments, the passivity of the populations, and the willingness of the victims to submit in desperate hope of surviving long enough to escape the German vise. A monumental, multifaceted study now contained in a single volume, Saul FriedlAnder's Nazi Germany and the Jews, 1933-1945 is an essential study of a dark and complex history.
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subset: commoncrawl


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TECH NOW: Making a splash with Sony's Xperia Tablet Z
Sony's new Xperia Tablet Z makes quite a splash. It's a super thin, sleek 10-inch touchscreen that weighs just over a pound. It's about as thick as a print magazine — just 6.9mm, which Sony says makes it the thinnest 10.1-inch tablet in its class. It has an upscale, elegant, all-glass aesthetic, and fits into a purse or backpack with room to spare. It also makes for a handy TV remote control, and can pair with an app to keep you tweeting, texting, and totally tuned in to all kinds of multimedia entertainment on your TV. The Tablet Z is also the first to use Qualcomm's Snapdragon S4 quad-core processor, which means that it's fast too.
The tablet is expected to be available at the end of May at $499 for a 16-gigabyte version or $599 for 32GB.
If thin, stylish, and fast were enough to truly take on the iPad, this would be an OK alternative for someone who simply prefers the Android operating system to Apple's iOS, or has other Sony gadgets for its One-touch sharing technology that makes use of near-field communication (NFC). But at the same price point as the iPad, it seems Sony knew it needed a product that could do something important that the iPad cannot: get wet.
RELATED:Scientifically tested Tablet reviews from Reviewed.com
RELATED:4 ways to make tablets better
The Tablet Z is waterproof. It can get splashed, soaked, and even downright submerged in water up to three feet for as long as 30 minutes. It's safe to spill on in the kitchen, snap photos on while perched poolside, and even lean up on the side of the tub to watch an episode of Downton Abbey while you relax in a bath. This is a feature that makes a messy busy mom like me very happy.
Will the waterproofing help make a serious dent against the market-leading iPad? No. After all, the iPad still has, as USA TODAY's Ed Baig points out, an embarrassment of riches when it comes to apps and overall ecosystem. Still, this is a device that should make Apple take note; it's time to up the game again — or at least waterproof it — if it wants to continue to float at the top of the tablet pool.
Jennifer Jolly is an Emmy award-winning consumer tech contributor and host of USA TODAY's digital video show TECH NOW. Email her at email@example.com. Follow her on Twitter: @JenniferJolly.


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LIEC: Continental Environment Interdisciplinary Laboratory
LIEC is a joint research laboratory (UMR 7360) created in January 2013 from the merger of LIEBE UMR 7146, LIMOS UMR 7137 and LEM UMR 7569, who contribute approximately half of the total staff.
The main objective of LIEC is to improve our understanding of continental ecosystems that have been highly disturbed by human activity, with the ultimate goal of their restoration.
To this aim, LIEC is involved in multi-disciplinary research that allies concepts and methods in environmental mineralogy, soil sciences, microbial ecology, physics and colloidal chemistry, eco-toxicology and functional ecology.


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Bob enters his 33rd season at the Academy. He is the leader of the Bears nationwide recruiting efforts and through his direct efforts, the Bears have consistently brought in outstanding freshmen classes.
Bono was an assistant coach at St. Bernard's High for 10 years prior to coaching at the Academy, as the Saints won a pair of state titles.
Bob has been a three-time selection to coach the Southeastern Connecticut entry in the Nutmeg games. His 1990 team won the gold medal.
Bono and his wife of 32 years, Doreen, have four children; Mike, Rob and twin daughters Jaclyn and Lisa.
(updated Oct. 2019)


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Sony Ericsson Xperia neo Pictures
The Sony Ericsson Xperia neo takes Android 2.3 Gingerbread mainstream, with its 3.7" 480x854 pixels screen, utilizing the Mobile BRAVIA Engine for enhanced sharpness and contrast when watching multimedia. The Sony Ericsson Xperia neo will come with support for HD video playback, HDMI-out port, an Exmor R sensor for the 8MP camera with LED flash. It is powered by a second generation 1GHz Snapdragon processor, so you can rest assured performance won't be an issue here.


text: Litigation Funding: Six Frequently Asked QuestionsNov 13, 2017 Sponsored by Bentham IMF | Lexpert Magazine October 2017 Issue Tweet Well-established in other common law jurisdictions, litigation funding is rapidly growing in Canada. Six questions that are frequently asked about litigation funding are below, as well as additional resources for learning more. Q1:What type of claim is suitable for commercial litigation funding and what are the investment criteria? A:A commercial litigation funder will fund all types of litigation or arbitration, including claims relating to breach of contract, breach of duty, intellectual property and insolvency. The claim should have strong prospects of success and a defendant able to satisfy a judgment. The budget should be approximately one-tenth of the realistic claim size to ensure that, on success, the litigant receives the majority of any recovery. A funder will undertake due diligence to ensure the case is meritorious and also consider factors such as how the litigation is to be managed, exposure to court ordered costs, and the likely time to resolution. Q2: What can a litigation funder provide and how does the funder get paid? A:Litigation funders typically cover all or a portion of legal fees and disbursements, as well as court-ordered costs. Litigation funders may also provide working capital, enabling a litigant to maintain or expand its business during litigation. The funding is non-recourse, meaning the funder is paid only on the successful resolution of the case. The funder's fee may be a multiple of the invested amount or a percentage of the resolution sum. If the case is lost, the funder receives no return, and will pay any court-ordered costs. Funding therefore enables a litigant to pursue a case without cost, and without risk. Q3: Is there any judicial guidance on funding of single-party commercial actions in Canada? A: In Schenk v Valeant Pharmaceuticals (2015) Justice McEwen examined the terms of the litigation funding agreement and found that there was "no reason why such funding would be inappropriate in the field of commercial litigation." He further held that funding agreements are acceptable if the funder did not stir up litigation, does not control the litigation, and its return is reasonable. Schenk also provides guidance on certain ethical issues, including reasonable funder returns, the funder attorning to the court's jurisdiction and funder's termination rights. For a more detailed discussion, visit the Legal Landscape section of Bentham's website. Q4: Why would a well-capitalized client use litigation funding? A: Sophisticated companies use external sources of capital to finance many parts of their business and see litigation funding as a financing and risk management tool to monetize litigation assets. As a funder pays the legal fees and disbursements, capital is freed up for other parts of the business. Further, because litigation funding is non-recourse and the funder typically covers any costs if the litigation is unsuccessful, the potential downside of pursuing litigation is removed. Shrinking legal budgets can mean that plaintiff-side litigation is left on the table. Litigation funding enables such claims to be pursued without stretching the budget. Q5: Who controls the proceedings where a litigation funder is involved? A: With a reputable litigation funder, the client controls the litigation. The funder will require updates on key developments and ask to be consulted on important decisions in order to monitor its investment. Where the litigation funder is an experienced ex-litigator, the funder can be used as a strategic sounding board. This consultative process is often considered valuable by clients and their lawyers. Control issues become most acute in the rare event that the funder and client disagree about a settlement offer. Bentham IMF's funding agreement includes a short fuse arbitration mechanism to resolve any dispute, as discussed here. Q6: Must the plaintiff obtain court approval of a litigation funding arrangement? A: The prevailing view is that court approval is not required outside the class action and insolvency contexts, where the court has an established supervisory role. This approach was confirmed by the recent decision in Seedlings v. Pfizer Canada Inc. (2017), where Case Management Judge Tabib held that there was no need to seek court approval, as "the manner in which [a plaintiff] chooses to fund a litigation it has every right to bring is of no concern to the Court or to the Defendant." For more information, visit www.benthamimf.ca or read one of the below articles dealing with a variety of issues and frequently asked questions: •eLitigation Funding in Arbitration: Three Recent Developments •eWhy Would a Well-Resourced Client Use Litigation Funding? •eWhere litigation is funded, who decides whether a settlement offer should be accepted? •eLet's Talk: Conversations About Litigation Funding •eThe Law on Maintenance and Champerty


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WASHINGTON — President Barack Obama claimed "full responsibility" Wednesday for fixing his administration's much-maligned health insurance website as a new concern surfaced: a government memo pointing to security worries, laid out days before the launch.
On Capitol Hill, Health and Human Services Secretary Kathleen Sebelius apologized to frustrated people trying to sign up, declaring that she is accountable for the failures but also defending the health care overhaul.
The website sign-up problems will be fixed by Nov. 30, she said, and the gaining of health insurance will make a positive difference in the lives of millions of Americans.
Obama underscored the administration's unhappiness with the problems so far: "There's no excuse for it," he said during a speech in Boston to promote his signature domestic policy achievement. "And I take full responsibility for making sure it gets fixed ASAP."
The website HealthCare.gov was still experiencing outages as Sebelius faced a new range of questions at the House Energy and Commerce Committee about a security memo from her department. It revealed that the troubled website was granted a temporary security certificate Sept. 27, four days before it went live Oct. 1.
The memo, obtained by The Associated Press, said incomplete testing created uncertainties that posed a potentially high security risk for the website. It called for a six-month "mitigation" program, including ongoing monitoring and testing.
Security issues raise major new concerns on top of the long list of technical problems the administration is grappling with.
"You accepted a risk on behalf of every user … that put their personal financial information at risk," Rep. Mike Rogers, R-Mich., told Sebelius, citing the memo. "Amazon would never do this. ProFlowers would never do this. Kayak would never do this. This is completely an unacceptable level of security."
Sebelius countered that the system is secure, even though the site's certificate, known in government parlance as an "authority to operate," is of a temporary nature. A permanent certificate will be issued only when all security issues are addressed, she stressed.
Spokeswoman Joanne Peters added separately, "When consumers fill out their online … applications, they can trust that the information they're providing is protected by stringent security standards and that the technology underlying the application process has been tested and is secure. Security testing happens on an ongoing basis using industry best practices."
Temporary certificate
The security certificate is required under longstanding federal policy before any government computer system can process, store or transmit agency data. The temporary certificate was approved by Medicare chief Marilyn Tavenner, the senior HHS official closest to the rollout. No major security breaches have been reported.
The memo said, "From a security perspective, the aspects of the system that were not tested due to the ongoing development, exposed a level of uncertainty that can be deemed as a high risk for the (federal marketplace website)."
It recommended setting up a security team to address risks and conduct daily tests, and said a full security test should be conducted within two to three months of the website going live.
A separate page stated that "the mitigation plan does not reduce the risk to the (website) itself going into operation on October 1, 2013. However, the added protections do reduce the risk to the overall Marketplace operations and will ensure that the … system is completely tested within the next 6 months."
That page was signed by three senior technical officials below Tavenner at the Centers for Medicare and Medicaid Services. All the officials deal with information security issues.
GOP questioning
Republicans opposed to Obama's health care law are calling for Sebelius to resign. She apologized to people having trouble signing up but told the committee that the technical issues that led to frozen screens and error messages are being cleared up on a daily basis.
Sebelius' forthright statement about her ultimate accountability for problems with the sign-up rollout came as Rep. Marsha Blackburn, R-Tenn., peppered her with questions about the "debacle."
"Hold me accountable for the debacle," Sebelius said. "I'm responsible."
Rep. Henry Waxman of California, the ranking Democrat on the committee, scoffed at Republican "oversight" of a law they have repeatedly tried to repeal.
"I would urge my colleagues to stop hyperventilating," Waxman said. "The problems with HealthCare.gov are unfortunate, and we should investigate them, but they will be fixed. And then every American will have, finally have, access to affordable health insurance."
Throughout the 3½-hour hearing, Sebelius was respectful, often addressing lawmakers as "sir" or "congresswoman." She kept her cool as some lawmakers repeatedly cut off her answers. But she did not shy a few times from tersely interjecting her views while a member was speaking.
The standing-room-only hearing room was silent when she swore an oath to tell the truth and began her opening statement. Addressing consumers who've tangled with the confusing system, Sebelius added, "So let me say directly to these Americans, you deserve better. I apologize."


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Set of Valentine's Cards - Stock Vectors
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Sources tell NBC 4 New York that earlier in the night, Brown sent a bottle of Champagne to Drake's table as a peace offering because the pair have had an ongoing dispute. Drake then allegedly sent back the bottle with a note that he was still sleeping with Rihanna, Brown's ex-girlfriend.
Brown's bodyguard has told detectives that the rappers exchanged words, sources said. And then as Brown was leaving the SoHo club with his bodyguard, members of Drake's entourage confronted him.
Witnesses say there was a brief staredown between the groups, and members of Drake's group removed their shirts. Pushing and shoving then ensued.
Sources tell NBC 4 New York that someone in the crowd threw ice, and then bottles were thrown.
Brown's bodyguard was struck in the head and Brown was escorted out of the club into a waiting car.
Five other people who were injured appeared to have no association with either singer.
At this point, a source says there's no indication Brown or Drake committed a crime.
Get the latest from NBC 4 New York anytime, anywhere. Follow us on Twitter, Facebook and Google+. Get our apps here and sign up for email newsletters here. Get breaking news delivered right to your phone -- just text NYBREAKING to 639710. For more info, text HELP. To end, text STOP. Message and data rates may apply.


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The 110611 model Pool Pump & Filter Cover is primarily designed to enclose equipment at the side of the house / tight areas - where access / thoroughfare is often limited. The reduced depth of 660mm (710mm if backless) will still fit most common sand and cartridge filters, yet allowing enough access between the box and the boundary fence / other hard surfaces. This model fits one large size filter (sand or cartridge), a motor / pump and a chlorinator.
This model is also available in Backless at no extra cost
Reduces noise by 80%! - Assembles in 15 minutes with absolutely NO NUTS / BOLTSor any TOOLS. Galvanised & Powder Coated - Rust Proof. Protects your Pool Pump / Filter with engineered ventilation gaps, easy lift our access from front & top.
The price does not include GST
1300 781 041 or Email us
The 110611 model Pool Filter / Pump Cover can be assembled in 15 minutes (on average) by one person with no handiwork experience or any tools.
The Material & Fabrication
The Pool Filter & Pump Cover weights approx. 60 KGS (in total) and made of 0.9mm thick Galvanised steel and finished with dense Powder coating. All external and internal accessories are either galvanized or made of solid stainless steel.
The Galvanization means that the box will not rust for 15+ years. The unique design and fabrication ensures withstanding the harsh Australian environment and extreme weather conditions.
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The box has 20mm thick dressed pine timber piece on the rear panel - for affixing controller units, Chlorinators and Power Points.
Engineered Ventilation Gaps
There're also 25mm ventilation gaps at the front and back of the box allowing for proper air-flow in and out of the box to protect the equipment.
Easy access – servicing equipment
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* Reduce noise by 80% wwhen purchased with optional acoustic foam - certified by an Acoustic Engineer -download the report here
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* Save money on design - A custom designed box made from timber or other material will usually cost more - and won't look as good!
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The Swimming Pool Filter & Pump Enclosure / Pool Equipment Cover / Shed - reduces noise by 80%! with our optional acoustic foaming - assembles in as little as 15 minutes with absolutely NO NUTS / BOLTS or any TOOLS. The Pool Pump Cover is made of Galvanised steel with powder coat finishing - providing protection against rust. The Pool pump shed is designed to protect your Pool Pump / Filter and other equipment.
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External: 1100(W) X 660(D) X 1145(H)
Internal: 1045(W) X 604(D) X 1100(H)
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1. The external measurements are actually the same as the internal measurements throughout the box with the exception of the bottom and top of the box - where the metal bends to allow for the acoustic foaming to be housed.
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The unique design of our Pool Filter & Pump Covers means that there are absolutely NO NUTS & BOLTS and NO need for any TOOLS to assemble the box. The 110611 box will take 15-30 minutes (on average) to assemble by one person with no prior handiwork experience.
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It's a really tough choice this week and your final decision is ultimately going to come down whether you want to play the man (Van Persie or Rooney) or the fixture (Balotelli, Bale, Adebayor, Dempsey etc). One of my off season projects is going to be to look back over the past few seasons to try and pin down which of these factors is more important, but until then we need to just use common sense. I would venture (though I'd be open to opposing opinions) that at the top end of the spectrum, the player is more important, regardless of who they are playing. Within reason then, you would captain Van Persie against virtually any opponent rather than a very good, but not world class player like Dempsey against a weaker one. This won't always hold up of course, but I think that's the way I'm leaning, at least when Van Persie/Rooney's fixture is still pretty promising.
[It isn't important here, but at the mid-low end of the price range I would generally rather have the player with the easier fixture than the better performances to date, so long at the two were somewhat comparable. I might, for instance, in a one week vacuum prefer Matt Jarvis at home to Bolton rather than Sigurdsson on the road at Spurs, despite the Icelandic midfielder's heroics so far].
With that in mind then, we're probably left with the same old duo of Rooney and Van Persie. On paper Rooney enjoys the slightly better fixture with Blackburn surrendering 27 goals at home to QPR's 24. However, if you place more stock in recent form, you will see that Blackburn have reduced their home GPG conceded from 2.1 over the first 7 home games to 1.5 over the last 8, while QPR's numbers are trending in the wrong direction, going from 1.4 over the first 7 to 1.8 over the last 8. I'm not sure there's enough here to suggest that Blackburn are now a much better defence than QPR, but it's probably enough to essentially make the strength of the fixture this week a tie.
Van Persie has the edge in terms of his performances on the road, though his last 5 games haven't quite been as spectacular as we had grown accustomed (5-13-2-2-6-2). Rooney has enjoyed a nice run over the last games but overall has fairly similar numbers to Van Persie over a comparable period. (5-8-12-2-2-7). Members at Fantasy Football Scout will also note that the pair are neck-and-neck in the ICT Index, which incorporates all elements which generally lead to fantasy success.
Van Persie is more likely to get a portion of any Arsenal goals scored (50% vs Rooney's 46%) though that too is a close race. I would venture that United are probably more likely to score more than Arsenal based on their better road attack (2.3 GPG vs 1.8 for Arsenal) along with their recent performances at Wolves, Tottenham and Chelsea, so Rooney probably gives you more chances of success. So again, we face a choice: do you want a bigger piece of a smaller pie or a smaller piece of a bigger pie? (Anyone else getting hungry now?)
If you've made it this far (well done), you are probably going to be mad that I am now going to totally sit on the fence and suggest this one is just too close to call. I think Van Persie has a higher upside and has delivered elite form on a more consistent basis this year, but Rooney plays on the stronger side who generate a lot of chances against all opponents and generally avoid the kind of off-days which have cursed Arsenal over the past few seasons. There isn't a hint of either player being rested, though in that category I'd say Van Persie has the slight edge given the quality behind Rooney (Hernandez, Welbeck, Berbatov) ready to come in for the odd game.
I will be handing Van Persie the armband once again but it's an incredibly close call, and to honest, one you shouldn't agonize over. Both are excellent plays this week and whatever happens, the decision to captain either will be a good choice.
As a final note, a couple of you may be wondering where the likes of Cisse and Pogrebnyak are in the above listings. My spreadsheet has a minimum number of minutes needed to qualify for captain consideration and neither player has yet met the mark. For reference, if they were included, Pogrebnyak would be the first choice player for the week with a 100 rating, while Cisse would come in with a very impressive 94, tied with Van Persie (whose number would be depressed by Pog's presence).
I considered reducing the requirements to allow these two players in, but the fact that Pogrebnyak would then be number one overall, confirms my hesitancy to include them. He's had a fine start to his Fulham career but I just don't see this form as being sustainable, given that he has scored on every single shot he's had on target. The best players in the world don't touch a goal every two shots so after the sample size increases you're going to see his production decline. Granted, that may not be in the next week but I'd prefer to avoid the perverse scenario where people quickly check the rankings and think I like these guys over the Van Persies of the world, hence their exclusion from the rankings until we understand their sustainable returns a bit more.
I've been a bit slow (at best) with responding to questions these past few weeks, but post them below or @plfantasy and I will get a reader questions post knocked out tonight, hopefully before the east coasters go to bed, and before the GMTers wake up in the morning. Thanks for your loyalty while the service has been down a bit, my task for the next year is to find a job whose busy period is outside the football season!


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This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.
Primary central nervous system (CNS) lymphoma is defined as lymphoma limited to the cranial-spinal axis without systemic disease. An increasing incidence of this disease has been seen among patients with acquired immunodeficiency syndrome (AIDS) and among other immunocompromised persons. The natural history of this disorder differs between patients with AIDS and those without AIDS. Computed tomographic (CT) scans may show ring enhancement in 50% of AIDS patients while patients without AIDS almost always show only homogeneous enhancement.[1] Both groups do equally poorly without therapy (1–3 month mean survival), but the overall survival for treated patients is much better for patients without AIDS (18.9 months) than for those with AIDS (2.6 months).[1,2]
Poor prognostic factors include the following:[3,4,5]
When tumor progression occurs, it is usually confined to the CNS and/or the eye. Occult systemic disease can be excluded by staging with bone marrow biopsy and CT scans of the chest, abdomen, and pelvis.[6,7]
In one prospective, case series of 282 patients, 17% were found to have meningeal dissemination by cytomorphology, polymerase chain reaction of rearranged immunoglobulin heavy-chain genes, or meningeal enhancement on magnetic resonance imaging.[8] The clinical impact of meningeal involvement on prognosis and therapy remains to be evaluated.
Although more than 95% of patients with primary CNS lymphoma have lymphoma of B-cell origin, 45 patients with CNS lymphoma of T-cell origin showed no difference in presentation or outcome in a retrospective series with data collected from 12 cancer centers.[9] Almost all primary CNS lymphomas are aggressive neoplasms of the diffuse large B-cell type. In a retrospective case series derived from 18 cancer centers in five countries of 40 patients with low-grade primary CNS lymphoma, a better long-term outcome was shown (7-year median survival) than is associated with the usual aggressive CNS lymphoma.[10][Level of evidence: 3iiiDiv] Anecdotal cases of primary CNS Hodgkin lymphoma have also been reported.[11]
Related Summaries
Note: Other PDQ summaries containing information related to primary CNS lymphoma include:
Because of the diffuse nature of central nervous system (CNS) lymphomas, aggressive surgical decompression with partial or gross total removal of the tumor is of no benefit to the patient. Median survival with surgery alone is in the range of only 1 to 5 months. Until the mid 1990s, radiation therapy had been the standard treatment, with doses of up to 45 Gy using standard fractionation. A prospective trial by the Radiation Therapy Oncology Group (RTOG-8315) used 40 Gy whole-brain radiation therapy (WBRT) and a 20 Gy boost to the tumor and found that the results were no better than had been previously reported with a median survival of 1 year and 28% of the patients surviving 2 years.[1,2] Disease recurs in the brain in 92% of patients despite high doses of radiation. The addition of spinal-axis radiation does not affect survival because it does not prevent cerebral relapse.
Two multicenter, prospective trials (including RTOG-8806) used preirradiation cyclophosphamide, doxorubicin, vincristine, and dexamethasone followed by WBRT.[3,4] Median survival times were no better than for radiation therapy alone. The failure of these and other combined modality trials [5] has been attributed to poor penetration of standard drugs through the blood-brain barrier and to increased neurologic toxic effects.[3,5,6,7,8,9,10] A retrospective review of 226 patients suggested improved results with the use of high-dose methotrexate or cytarabine with radiation therapy rather than with other combination regimens.[11]
A multicenter trial (RTOG-9310) of 102 patients used high-dose methotrexate (2.5 g/m2) for five cycles, intravenous vincristine, oral procarbazine, intraventricular methotrexate, and either 45 Gy of WBRT or 36 Gy in a hyperfractionated schedule.[12] Median progression-free survival (PFS) was 24 months, and median overall survival (OS) was 37 months.[13][Level of evidence: 3iiiA] Severe delayed neurologic toxic effects were seen in 15% of patients.
Another multicenter trial (EORTC-20962), which is now closed, was comprised of 52 patients younger than 66 years who used high-dose methotrexate, teniposide, carmustine, methylprednisolone, intrathecal methotrexate, cytarabine, and hydrocortisone followed by 40 Gy of radiation therapy; the median survival was 46 months, but a 10% toxic death rate occurred even in this younger patient population.[14][Level of evidence: 3iiiA] Follow-up was too short (median 27 months) to fully assess severe delayed neurologic toxic effects.
Because of unsatisfactory results of WBRT alone and the neurologic toxic effects of chemotherapy and radiation therapy, a major focus is now on trials with chemotherapy alone.[15] Multiple reports have described systemic chemotherapy, which has been employed alone or with osmotic blood-brain barrier disruption, usually including high-dose methotrexate with frequent hospitalizations.[8,10,16,17,18,19,20,21]
A multicenter trial (NABTT-9607) evaluated high-dose methotrexate alone (8 g/m2) for newly diagnosed patients, with WBRT administered only at disease recurrence. With a median follow-up of 2 years, median PFS was 13 months and median OS had not been reached at 23 plus months.[22][Level of evidence: 3iiiA] Another multicenter trial (EORTC-26952) of 50 patients older than 60 years used high-dose methotrexate (3 g/m2 /cycle), lomustine, procarbazine, methylprednisolone, and intrathecal methotrexate and cytarabine. The 1-year PFS was 40%, and the median OS was 14.3 months in this older patient group with a median age of 72 years.[23][Level of evidence: 3iiiA] Another multicenter trial of 65 patients used both high-dose methotrexate and high-dose cytarabine, including ifosfamide, cyclophosphamide, vinca alkaloids, dexamethasone, and intrathecal methotrexate, cytarabine, and prednisolone. The median time-to-treatment failure was 15 months with a median survival of 34 months; 57% of patients age 60 or younger were still alive at a median follow-up of 8 years.[24,25][Level of evidence: 3iiiA]
Severe delayed neurologic toxic effects were rarely seen in these chemotherapy-only trials (in the absence of subsequent radiation therapy). Reduction of dosage for subsequent radiation to 23.4 Gy has been applied for patients who achieve clinical complete response after induction chemotherapy.[26][Level of evidence: 3iiiDiii] Intensive chemotherapy with autologous peripheral stem cell transplantation is also under evaluation; neurologic toxic effects were not reported in the absence of radiation therapy.[27,28,29,30,31] These phase II results have never been tested in a randomized setting because of an insufficient number of patients.
Severe cognitive deficits are reported with all intensive therapies due to iatrogenic leukoencephalopathy. Retrospective data suggest a decreased risk of dementia when chemotherapy is employed prior to radiation therapy and even less when radiation therapy is avoided.[11,32,33] The use of systemic chemotherapy alone, with or without osmotic blood-brain barrier disruption, may avoid the cognitive loss observed with radiation therapy.[11,16,17,33] Comparative trials with validated measures of cognitive function will be necessary to determine the value of delaying radiation therapy until relapse after high-dose chemotherapy.[22,33,34,35,36] Glucocorticoids can also produce substantial but short-lived remissions. Steroid efficacy may complicate the diagnostic evaluation by obscuring the histologic findings. Other drugs that cross the blood-brain barrier are under clinical evaluation.[37,38]
In a prospective, randomized trial of 551 immunocompetent patients with newly diagnosed primary CNS lymphoma, all patients received induction chemotherapy with six cycles of high-dose methotrexate (4 g/m2) with or without ifosfamide.[39] Upon completion of chemotherapy, responders were randomly assigned to WBRT (45 Gy) or to no treatment for complete response patients and cytarabine for partial response patients. There was no statistical difference in median OS with 32.4 months for patients receiving radiation therapy versus 37.1 months for those not receiving radiation (hazard ratio [HR] = 1.06; 95% confidence interval [CI], 0.80–1.40, P = .71).[39][Level of evidence: 1iiA] Treatment-related neurotoxicity was significantly worse on the radiation therapy arm, and such toxicity must be weighed against the possibility that the survival from chemotherapy alone may be marginally inferior to the survival when radiation is added.
Patients with acquired immunodeficiency syndrome (AIDS) associated primary CNS lymphoma usually have very advanced human immunodeficiency virus (HIV) infections with CD4 counts less than 50 cells/mm3.[40] Consequently, most patients die of opportunistic infections regardless of therapy for the lymphoma. Groups that benefit most from radiation therapy, with or without antecedent chemotherapy, include those HIV-seropositive patients with no prior opportunistic infections or tumors for whom the CNS lymphoma is the AIDS-defining illness, and those patients with a good performance status, high CD4 lymphocyte count (>100mm3), and symptoms referable only to the CNS lymphoma.[32,41] Treatment of these patients requires special consideration. (Refer to the PDQ summary on AIDS-Related Lymphoma Treatment for more information.)
An international consortium performed a retrospective review of 83 HIV-negative patients with primary intraocular lymphoma.[42] In selected patients with no evidence of disseminated CNS disease, localized therapy with intraocular methotrexate or ocular radiation therapy is associated with equivalent outcomes seen with systemic chemotherapy and/or WBRT. Localized therapy with intraocular methotrexate or ocular radiation therapy did not affect relapse rate, median PFS, or median OS as compared to systemic chemotherapy and/or WBRT.[42][Level of evidence: 3iiiDiv]
Current Clinical Trials
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with primary central nervous system non-Hodgkin lymphoma. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Editorial changes were made to this summary.
Purpose of This Summary
This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of primary CNS lymphoma. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.
Reviewers and Updates
This summary is reviewed regularly and updated as necessary by the PDQ Adult Treatment Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH).
Board members review recently published articles each month to determine whether an article should:
Changes to the summaries are made through a consensus process in which Board members evaluate the strength of the evidence in the published articles and determine how the article should be included in the summary.
The lead reviewers for Primary CNS Lymphoma Treatment are:
Any comments or questions about the summary content should be submitted to Cancer.gov through the Web site's Contact Form. Do not contact the individual Board Members with questions or comments about the summaries. Board members will not respond to individual inquiries.
Levels of Evidence
Some of the reference citations in this summary are accompanied by a level-of-evidence designation. These designations are intended to help readers assess the strength of the evidence supporting the use of specific interventions or approaches. The PDQ Adult Treatment Editorial Board uses a formal evidence ranking system in developing its level-of-evidence designations.
Permission to Use This Summary
PDQ is a registered trademark. Although the content of PDQ documents can be used freely as text, it cannot be identified as an NCI PDQ cancer information summary unless it is presented in its entirety and is regularly updated. However, an author would be permitted to write a sentence such as "NCI's PDQ cancer information summary about breast cancer prevention states the risks succinctly: [include excerpt from the summary]."
The preferred citation for this PDQ summary is:
National Cancer Institute: PDQ® Primary CNS Lymphoma Treatment. Bethesda, MD: National Cancer Institute. Date last modified <MM/DD/YYYY>. Available at: http://cancer.gov/cancertopics/pdq/treatment/primary-CNS-lymphoma/HealthProfessional. Accessed <MM/DD/YYYY>.
Images in this summary are used with permission of the author(s), artist, and/or publisher for use within the PDQ summaries only. Permission to use images outside the context of PDQ information must be obtained from the owner(s) and cannot be granted by the National Cancer Institute. Information about using the illustrations in this summary, along with many other cancer-related images, is available in Visuals Online, a collection of over 2,000 scientific images.
Based on the strength of the available evidence, treatment options may be described as either "standard" or "under clinical evaluation." These classifications should not be used as a basis for insurance reimbursement determinations. More information on insurance coverage is available on Cancer.gov on the Coping with Cancer: Financial, Insurance, and Legal Information page.
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Before I lived in NYC, I paid $30 a month for a very decent gym. But after my move to the big city, my gym membership fees – along with the cost of rent, a glass of wine, and a cheeseburger – skyrocketed. Now I'm shelling out $95 each month so I can squeeze in a little cardio. And at the end of each month, when my account is drained, I wonder about ways I can keep in shape on the cheap.
High prices aren't the only reason to forgo a gym membership. Some of us are too busy to fit it in; others don't like sharing treadmills or pouring sweat around strangers; others just struggle with commitment. Regardless, it's important we stay active in our 20s. And though our energy may come in spurts (often hindered by working long hours or pulling all-nighters), and our daily "routines" don't always fall in line, staying in shape can be simple – and cheap! If the gym isn't for you, here are some other ways to keep moving.
1. Ride a bike.
The upside: Riding your bike not only gets you where you want to go, it's a great workout and a lot of fun. I ride whenever I have the chance, and if you've never gotten into the habit, it's worth a try. Not to mention, it's a greener way to get around. Try swapping out your car keys for a simpler set of wheels next time you're out running errands.
The downside: Helmets are no fashion statement, and I'm a wimp in winter weather; during the colder months, my bicycle doesn't see the light of day very often. In addition, if you don't currently have one, buying a bike can put a dent in your funds. (If you're not picky, you can find an old rickety ride for less than 100 bucks.) Also to keep in mind: if you're new to biking, brace yourself for a bruised butt.
2. Play ball.
A few pros: If you do a little digging, you'll find that most cities and communities have sports leagues for folks of all levels of athletic prowess. Whatever you like to play – basketball, kickball, fencing – there is likely a league for you. Joining a team gives you a reason (and a schedule) to get out of the house and break a sweat. And you may make some new friends while you're at it. But if there's not an official league for your sport of choice, grab a group and start your own.
A few cons: While it varies from sport to sport, joining a league can get a little pricey. A friend of mine who plays soccer in NYC forks up $200 each season (for four seasons a year). Still, do the math: it's cheaper than my gym membership. Other cons include a lack of variety and greater chance for injury.
3. It may not sound like much, but walk!
Why: Experts say that if you can walk 30 minutes a day, you're making your way towards a healthy lifestyle. Living vehicle-less in NYC, I walk more now than I ever imagined I would. While other cities aren't as conducive to pedestrianism, it's easy to get going. Programs such as 10,000 steps promote a walking lifestyle and suggest wearing a pedometer to keep track of your tracks. If you have trouble getting motivated, make changes to your lifestyle that make it necessary to walk (been thinking about getting a dog?).
Why not: If shedding pounds is your goal, you may need to step it up a bit. Add walking to your regimen.
4. Take a class.
The good: Have you ever seen the abs on a belly dancer? Plenty of classes offer workouts that break the mold of your average spinning or aerobic sessions. Tap dancing. Salsa. Kickboxing. Karate. Trampolining. You get the picture. Most classes are commitment-free and a blast.
The bad: If you pay per class, costs can add up.
5. Turn on the TV.
Advantages: If you are forgoing gym membership costs in exchange for a plethora of TV channels (hey, we all have our priorities), there's a good chance your tube includes a channel dedicated to exercise. Somewhere up in the 1000s, I can access Exercise on Demand, giving me the ability to control my workout with my remote. Choices include 10 Minute Workouts (great for a pre-work workout), Yoga Body Makeover, Hollywood Body, Jillian Michaels (of The Biggest Loser fame), Dance Party, and more. If you can get yourself up off the couch, you're good to go.
Disadvantage: Every once in a while, we all need to get some fresh air.
Put on your iPod and run up and down some stairs. Mow the lawn. Run around the block. Do some gardening. Walk to your friend's house. Just get moving.
What do you do to stay active?


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High Point: Irish Wolfhound Breeders
Below is a sample search of our Irish Wolfhound breeders with puppies for sale. The search tool above returns a list of breeders located nearest to the zip or postal code you enter. From there you can see photos of their pups, find detailed information on their web page and contact them by email, phone or even get driving directions.
(Detailed contact information has been omitted. Enter your zip or postal code above to access our up-to-date directory).
This is a FREE search tool! Use the form at the top to get complete listings for breeders in your area!
Additional Information: 10 healthy unregistered Irish Wolfhound pups. Mom and Dad both on site, Mom is registered, Dad is not.
We first bought our male (Kano) 4 years ago, he was a birthday present for my husband. We didn't know much about the breed and it was very... ...
ShagBark Irish Wolfhounds
Additional Information: My wolfhounds are household companions and my wish is that pups go to forever homes where they are with you indoors and out. They are microchipped, AKC reg., UTD on vaccines & heartworm prevention.
$1800. Non-refundable down payment is $200. Liver shunt tested. Microchipped ...
Additional Information: We have 36 years of experience breeding champion quality Irish Wolfhounds. We breed for temperament, health and longevity. No line breeding. AKC registered out of excellent pedigrees. All puppy shots.
Updated 08/20/2019: Beautiful litter of six Irish Wolfhound puppies born 6-23-19. Off to a great start. Four males and two females. Ready to go.... ...
Important: breeders.NET has not screened the listed breeders and accepts no responsibility for their reputation or quality. It is your responsibility to investigate. See How to Find a Dog.


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The liquid version of our deodorant crystal. Simply, purified water and pharmaceutical grade mineral salts, and Lavender scent. Highly recommended by doctors--oncologists, dermatologists, and allergists. 100% pure and natural, hypoallergenic, 24 hour protection, and fragrance free. Extremely gently yet amazingly effective.
For those who prefer a scented deodorant, we now offer Lavender as an Allergen Free fragrance to our formula. Our fragrances are 100% Phtalate and Allergen Free, and 100% pure and natural. The fragrances are a blend of natural oils, resins and extracts. They follow INCI regulations for fragrances and labeling, and are IFRA Certified.
* [1] Note: Unless otherwise noted, this product has not been evaluated by the Food and Drug Administration. Our natural products are not intended to diagnose, treat, cure, or prevent any disease.


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June 29, 2010, 5:43 pm
Three-way statehouse primary stirs up Douglas County Republicans
The Colorado Statesman examined Douglas County politics when looking at the three-way GOP primary to replace House Minority Leader Mike May, who is term limited.
"The contentious contest has erupted with snipes at the candidates and exposed an undercurrent of factions in the Douglas County GOP that some say pits a powerful 'good old boy' club against rank-and-file Republicans," the Statesman writes.
The candidates are Parker mayor and school teacher David Casiano; Chris Holbert , former president of the Colorado Mortgage Lenders Association; and Polly Lawrence, a principle in Lawrence Construction Co.
The full article can be read here.


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Food, Family and Fun
Animals for Adoption
Your Fork
cream and historic trees at Lincoln Tomb
Association offers ice cream social and new tour of
trees at historic Oak Ridge Cemetery on May 24
Send a link to a friend
[May 17, 2014]
The Lincoln Tomb State Historic Site will mark Memorial Day weekend
with an old-fashioned ice cream social and a brand-new presentation
on historic trees.
From 1-4 p.m. on Saturday, May 24, visitors can enjoy cake and
ice cream for a nominal fee – an event reminiscent of the past, when
families would gather at scenic Oak Ridge Cemetery for picnics on
summer Sundays.
The Springfield Municipal Band will be there, along with
representatives who will describe restoration of the "original"
First Street entrance to the cemetery.
The Lincoln Monument Association will also introduce a new tree tour
that uses modern technology to present the history of the cemetery.
Twelve historic trees have been given markers that describe the
tree, provide GPS coordinates and offer a QR code that provides
pictures and additional information.
Each tree will have an interpreter to relate important historic and
horticultural facts.
A new website describes the trees:
They include oaks that stood when Abraham Lincoln was buried, a
cottonwood that may be the biggest tree in Springfield and an
example of the only magnolia native to Illinois.
[to top of second column]
Eventually, about 250 trees will be identified on future tours.
The tree tours are a joint effort of the Lincoln Monument
Association, Oak Ridge Cemetery Foundation, Illinois State
Historical Society and Guy Sternberg from Starhill Forest Arboretum.
[Text received; CHRIS WILLIS,
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John Barnes Chosen to Lead Youngstown State's Women's Basketball Program
by YSU
Saturday, Apr 6, 2013 1:09 pm
Barnes, who will be introduced to the Youngstown community and media next week, is the seventh head coach in program history. The 40-year old comes to the Penguins after serving as associate head coach at Green Bay last season and spending the previous two seasons as an assistant in the Big Ten. He led Division II Michigan Tech to 156 wins and five appearances in the NCAA Tournament as the Huskies' head coach from 2003-10.
Barnes has been to the postseason 12 times in his 17 seasons as a college coach, including each of his three seasons at the Division I level. He has spent his entire collegiate career in the Midwest, and his teams have posted a winning record in all 17 of his seasons.
"Coach Barnes has an incredible track record of success as both a head coach and an assistant in our region," Youngstown State Executive Director of Intercollegiate Athletics Ron Strollo said. "He was outstanding at resurrecting Michigan Tech into a national powerhouse as its head coach, and he has worked for very successful head coaches at prominent programs at the Division I level. He has built recruiting relationships throughout the Midwest, and he is obviously familiar with the Horizon League from his time at Green Bay. We're very excited to welcome Coach Barnes to Youngstown State, and we look forward to him continuing to lead us toward the top of the conference."
Most recently, Barnes was the associate head coach under Kevin Borseth at Green Bay as the Phoenix won the Horizon League regular season and tournament titles in 2012-13. Green Bay finished 29-2 and was ranked in the top 20 in both the Associated Press and USA Today Coaches polls. Barnes also coached with Borseth at Michigan in 2011-12 and helped lead the Wolverines to just their fourth 20-win season in school history and their first at-large berth into the NCAA Tournament in 11 years. Barnes helped lead Wisconsin to the second round of the Women's National Invitational Tournament and a third-place finish in the Big Ten in 2010-11, which was his first at the Division I level.
Prior to joining Wisconsin's staff, Barnes spent seven seasons leading one of the top Division II programs in the country at Michigan Tech. The Huskies went 156-55 in his seven campaigns, qualified for the NCAA Tournament five times and won the Great Lakes Intercollegiate Athletic Conference Tournament three times. Michigan Tech advanced to the Elite Eight of the NCAA Tournament in each of his last two seasons, and Barnes culminated his career by being named the WBCA Region Coach of the Year in 2009-10. The Huskies went 31-3 that season, setting school records for wins and winning percentage while being ranked No. 1 in the country for seven weeks. Barnes was named the GLIAC Coach of the Year in each of his final three seasons at Michigan Tech.
On the individual level, Barnes has a proven record as a recruiter and on-floor coach. He had a hand in signing Wisconsin's Miss Basketball at Green Bay, Michigan's Miss Basketball at Michigan and the Michigan Miss Basketball runner-up at Wisconsin. Barnes was in charge of coaching Green Bay's defense that allowed 49 points per game, the second-fewest in the country. He worked primarily with the Wolverines' post players while coordinating all scouting of opponents in his season in Ann Arbor, and he focused on offensive efficiency and player development in his year at Wisconsin. At Michigan Tech, Barnes recruited and developed the only First-Team All-American in school history, two GLIAC Players of the Year and two Academic All-Americans. The Huskies' team grade-point average ranked in the top five nationally four times in his seven seasons.
Before becoming the head women's coach at Michigan Tech, he spent six years on the men's staff at the Houghton, Mich., campus as an assistant coach. Barnes played an integral role in building the men's program into national prominence as the Huskies went 133-48 while winning the GLIAC North Division four times and making four NCAA Tournament appearances. In 2002-03, his final season on the men's staff, Michigan Tech went 29-3 overall, captured GLIAC regular season and tournament titles and was ranked atop the national poll for a period.
Barnes was a four-year member of the men's team at Michigan Tech from 1991-95 and earned a spot on the GLIAC All-Defensive Team as a senior. He got his start as a collegiate coach as an assistant at Lake Superior State in 1995-96, helping the Lakers win the GLIAC North Division. Barnes spent a year overseas serving as a player-coach for the St. Nicolai Basketball Club in Denmark in 1996-97 before starting his six-year stint at his alma mater.
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The Jan. 1, 1951, issue of LIFE magazine featured a number of articles that, today, feel very much of their own time. For instance, there was a cheerful portrait of an Atomic Energy Commission plant at Oak Ridge, Tenn., "where half of the nation's A-bomb fuel is made"; a celebration of the GM Le Sabre as "the car of the 1960s"; and a photographic paean to "West Coast Youth" captured by LIFE's Loomis Dean in an article subtitled, "Brawny and Buoyant, It Is a Bright Asset for the U.S. Future."
Noting that "just as the West Coast tends to produce bigger and better fruits and vegetables, it is producing a healthier and statistically bigger crop of youngsters," the article continued:
From the sun-drenched valleys of Southern California to the rain-drenched inlets of Puget Sound this new race of children . . . [has] one big thing in common. It is a lust for the outdoors, and the richly scenic coast offers kids a maximum of temptation and a minimum of inconvenience in fulfilling it. . . . [Here] LIFE shows some splendidly healthy West Coast youth energetically using its splendid outdoors. What use this generation eventually will make of its own tremendous energy, heaven only knows, but properly directed it should be sufficient to move the world.
Anyone who makes it all the way through the photo gallery above, meanwhile, will surely notice that, with perhaps one or two hard-to-find exceptions, the youth pictured here are exclusively white. In the early 1950s, it seems, LIFE magazine—even after the cataclysmic, worldwide "fight for democracy" of the previous decade—didn't feel compelled to acknowledge the millions of black, Asian and Latino kids living on the West Coast.
Seen in that light—and with the knowledge that the first rumblings of the nascent Civil Rights Movement were just a few years away—it's tempting to view these pictures as historical artifacts of a specific type: namely, a quaint record of what so many in the media wished 1950s America to be, rather than a chronicle of what 1950s America really looked, acted and sounded like.


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Long Mile Road, Walkinstown, Co. Dublin
The Long Mile Inn was taken over in 2005 by Larry O'Shea and Kevin Bissett. It was renovated in 2007 to a higher standard which has resulted in teh pub winning wards for "Best Shop Front". The bar has been extended to cater for our sporting
Read more about The Long Mile Bar and Bistro | View Map of Area | Photos


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You know the Alien? He's back in town! I will be showing you "how to draw Aliens step by step". H.R Giger was the creator of the Alien. James Cameron came across his work at an art gallery. After seeing H.R Giger's work James Cameron contacted Giger, and asked him to design one of his Aliens for the sci-fi move Alien. Alien was a big blockbuster hit in the 1970's lead star was Sigourney Weaver who played Ellen Ripley. After the success of Alien, it was followed by parts two, three and four. Seven years after Alien Resurrection, AVP was released in 2004, which was labeled as a mediocre movie. This tutorial teaches the artist "how to draw alien", or this acid filled creature from outer space. All you need is a clean sheet of paper, a pencil and you might wanna grab an extra eraser as well. I also have a new version that will teach you how to draw an alien. Enjoy your lessons guys!
DragoArt members upload artwork and drawing tutorials! They are also allowed to leave comments on tutorials, profiles, etc. Many more features, as well; it's way better than just being a boring guest! Register Now!


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- Marussia news
Marussia to launch at Jerez
- Teams:
- Manor
Marussia will unveil the MR02 at the first pre-season test at Jerez on February 5.
The new 2013 car will be launched in the pit lane at 08.15 CET (07.15 GMT) ahead of the first day of testing, with Max Chilton driving the car on the opening day of the test. Chilton's team-mate has yet to be confirmed after Timo Glock left the team by mutual consent early in January, with reports in Brazil claiming Luiz Razia will take the vacant seat.
A press release from Marussia stated that the rest of the team's pre-season testing schedule will be announced on the day of the launch.
The launch will follow Mercedes and Toro Rosso on February 4, with Caterham also opting for a pit lane launch on the same day as Marussia. The announcement confirms Williams as the only team not to have its 2013 car ready for the opening test of the year, with the team having opted to launch its car in time for the second test in Barcelona on February 19.


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ROCHESTER — Police are searching for two armed gunmen who robbed the Shell station on Milton Road Wednesday evening, during a pouring rainstorm that swept through the area.
ROCHESTER — Police are searching for two armed gunmen who robbed the Shell station on Milton Road Wednesday evening, during a pouring rainstorm that swept through the area.
The robbery occurred Wednesday at 5:14 p.m. at the Shell gas station located at 198 Milton Road. Police said both suspects, described as white males, entered the store with guns — one suspect was holding what police suspect was a sawed-off, gray camouflaged pattern shot gun. The other was holding what police described as a long-barreled handgun. No one was hurt in the robbery.
After the suspects demanded money, the clerk gave them an undetermined amount of cash from the register and the suspects fled. Police said the suspects were seen running towards Milton Road heading northerly.
Several customers were at the store as were two store clerks, during the robbery, police said.
At 6 p.m., Rochester police officers were seen walking along the side of Milton Road (Route 125) with a police bloodhound, as officers investigated the scene. Assistance was provided by Maine and N.H. State Police K9 units.
The Shell gas station was closed after the robbery, but was expected to later reopen.
Police Sgt. Eric Babine said both suspects had a piece of clothing, such as a bandana, covering their faces. He said police plan to review the video surveillance at the store to identify the suspects.
One suspect is described as a white male with a heavy build, 5-foot-8 to 6-feet tall, with light skin, 18-25 years old, with blonde hair, wearing a New England Patriots baseball hat with a red bandana covering his face. He was wearing a blue shirt with white stripes.
The other suspect is said to be thin, standing 5-foot-8 to 6-feet tall, wearing a dark blue hoodie and had a cloth covering his face. He was wearing a dark brimmed baseball hat and brandished a long-barreled hand gun.


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Icon celebrates 30th anniversary of Christmas & Hits tour
Embarking on his 30th anniversary of his Christmas & Hits Tour, fans will get an early Christmas present when the iconic Kenny Rogers performs in the Event Center at L'Auberge du Lac in Lake Charles on Friday, Dec. 9, at 8:30 p.m. Tickets for this show, which is restricted to ages 21 years and older, are $55-$45 and can be purchased at the L'Auberge Business Center, online at ticketmaster.com or by phone (800) 745-3000.
The Houston-born 73-year-old Rogers will sing some of his favorite holiday classics and will be joined on stage by a local children's choir during parts of the show. If that's not an incentive, Billy Dean will also share the stage with Rogers. Of course the night would not be complete without hearing some of Rogers' biggest hits.
"I think a Christmas audience comes to a show with a different mindset that any other," Rogers told Billboard magazine. "A Christmas audience comes in and they say, 'I really want to enjoy this.' Someone coming into a regular show wanting to hear the hits will say, 'Make me enjoy this.' I think they're there to be happy."
Rogers released his first holiday themed album in 1981 called Christmas, and he went on to record seven more including his first live holiday record in 2010.
"Thirty years is a long time to do anything, but a Christmas show seems to get easier every year, especially when I get a chance to work with friends like Billy Dean," added Rogers. "He always brings a great energy and beautiful music to the event."
Dean, who previously worked with Rogers, released his first of 10 studio albums in 1990 and saw success with the singles "Only Here for a Little While," "Somewhere in My Broken Heart," "Let Them be Little," "We Just Disagree," "If There Hadn't Been You" and "Billy the Kid."
Expect to hear songs such as "White Christmas," "Joy to the World," "O Holy Night," "Let It Snow! Let It Snow! Let it Snow!," "I'm Dreaming of a White Christmas," and "'Til The Season Comes 'Round Again."
After graduating from Davis High School in Houston, Rogers sang in groups like The Scholars, The Bobby Doyle Trio and The New Christy Minstrels before settling with Kenny Rogers and The First Edition, with whom he recorded "Ruby, Don't Take Your Love To Town."
His first original solo album came in 1976 with Love Lifted Me then came a string of five consecutive No. 1 albums, two of which, The Gambler and Kenny, combined to sell more than 10 million copies.
Singles like "Lucille," "Daytime Friends," "Love or Something Like It," "The Gambler," "She Believes in Me," "You Decorated My Life" and "Coward of the County" reached No. 1 on the country charts and helped Rogers become a household name.
It was also during that time that Rogers met up with the late Dottie West, and the two recorded a No. 1 album Every Time Two Fools Collide in 1978.
He later went on to score major success by teaming with Kim Carnes in 1980 with "Don't Fall in Love with a Dreamer," then with Sheena Easton in "We've Got Tonight."
Fellow musician Ronnie Milsap and Rogers recorded "Make No Mistake, She's Mine," and who could forget "Islands in the Stream" with Dolly Parton?
In 1981, Kenny also collaborated with the great Lionel Ritchie, who wrote and produced one of Rogers' biggest songs — "Lady."
It was also during that time that Rogers jumped to the big screen and landed the lead role as a racecar driver in the 1982 hit Six Pack, which also starred the young Diane Lane and Anthony Michael Hall. He later starred in made for television movies The Gambler and Coward of the County.
Hits continued during the second half of the '80s and Rogers also took part with 44 other musicians for the "We Are the World" charity song in 1984 and co-hosted the American Music Awards in 1987.
While Rogers wasn't as active in the studio during the '90s, he returned in 2000 with "Buy Me a Rose" and became the oldest (61) artist in the history of country music to have a No. 1 record, breaking what was then a 26-year-old record held by the legend Hank Snow. However, Rogers' record was broken some three years later by Willie Nelson (70).
In 2008, Rogers signed a deal to release an album titled 50 Years, which was sold exclusively at Cracker Barrel and also contained three new songs.
As of 2011, Rogers has recorded 65 albums, sold over 190 million records and is the only artist to chart a record in the last six decades. Popular soundtracks such as Urban Cowboy (1980) and later The Big Lebowski (1998) helped bring the music of Kenny Rogers to new generations of listeners.
Despite countless honors and a storied career, Rogers has recently claimed that he is working on a new album. So don't let the silver hair fool you. It's been that way for decades, and Kenny Rogers appears to have plenty of good music and live performances left. Drop in on him at L'Auberge on Dec. 9 and see what condition his condition is in.


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How to Style Your Sound in Mountain Lion
Out of the box, OS X Mountain Lion comes with a preset collection of beeps and controls. By using the Sound Preferences pane, however, you can change the way your Mac plays and records sound by changing settings on each of its three tabs: Sound Effects, Output, and Input.
Three items appear at the bottom of the Sound pane, no matter which of the three tabs is active:
To make your Mac's volume louder or softer, use the Output Volume slider. You can also change or mute the volume with the designated volume and mute keys found on most Apple keyboards.
Select the Mute check box to turn off all sound.
Click the Show Volume in Menu Bar check box to add a volume control menu to your menu bar.
A shortcut to the Sound System Preferences pane is to press Option while pressing any of the volume keys (usually the F4 and F5 keys on older laptops and keyboards or the F11 and F12 keys on newer laptops and keyboards).
How to change sound effects
On the Sound Effects tab, choose an alert (beep) sound by clicking its name; set its volume by using the Alert Volume slider control.
You can also specify the output device through which sound effects play (if you have more than one device) by choosing it from the Play Sound Effects Through pop-up menu.
The Play User Interface Sound Effects check box turns on sound effects for actions, such as dragging a file to the Trash. The Play Feedback when Volume Is Changed check box tells your Mac to beep once for each key press to increase or decrease volume.
Choose output and input options
If you have more than one sound-output device (in addition to the built-in speakers), you can choose it here. The Balance slider makes one stereo speaker — left or right — louder than the other.
If you have more than one sound-input device (in addition to the built-in microphone on many Macs or an iSight camera, which contains its own mic), you can choose it here.
The Input Volume slider controls the Input Level (how loud input from that device will be), which is displayed as a row of blue dots. If the dots light up all the way to the right side, your input volume is too loud. Ideally, the input level should light up with about three fourths of the little blue dots — and no more.


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Large Stroller Mobiles
Large trolley mobile with three animals on. It is of premium quality and has many beautiful details. The animals easily turn, so that both mother and child can see them. The animals have rattle inside, so it makes a soft rattle sound when you shake them It is hand crocheted from Oeko-Tex 100 certified (Confidence in Textiles) bamboo yarn. We use very soft bamboo yarn, which is perfect for babies and small children. Furthermore, the bamboo yarn has the FSC certification, which means that nature has been taken into consideration both when cultivating and harvesting the bamboo. The stuffing is polyester. It is very popular as maternity gift or as a christening gift. The animals can be hand washed at 30 degrees Celsius. The wooden discs and the clips can be washed with a wet cloth. The product also has the CE mark.


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With little more than a week until the scheduled start of the school year, B.C. Teachers' Federation president Jim Iker called on the government to enter mediation immediately.
During the BCTF summer leadership conference in Kamloops, where more than 500 striking teachers gathered during the weekend, Iker urged the government to come to the negotiating table as soon as Monday morning.
"We're ready to negotiate anytime. We have been ready all summer. We have been ready all this whole week. ... How about tomorrow?" Iker said Sunday.
The teachers held a special representative assembly Friday night, where voting members discussed the job action. The results of the discussion and any direction given to Iker is not public at this time, but the speech on Sunday was open to the media.
Last week, Education Minister Peter Fassbender said the government is ready to negotiate "24-7" with teachers, who went on strike June 17, closing schools during the final two weeks of the school year. Fassbender said the government is not prepared to legislate a settlement in the dispute.The minister wasn't available for comment Sunday.
With schools set to reopen Sept. 2, the two sides are hundreds of millions of dollars apart on class size and composition, although they are close on wages.Meanwhile, parents are left trying to make alternative arrangements for child care.Veteran mediator Vince Ready said earlier this month that he will monitor the situation and could mediate the dispute in the future if both sides reach a point where mediation would be productive.
The province has promised that if the dispute continues past Sept. 2, parents will be given a $40-per-day subsidy to help pay for child care for approximately 340,000 students under the age of 13 who will be out of class.
The payments will come from the $12 million the government estimates it will save during the strike, and will be given in a lump sum once the dispute is settled.B.C. has more than 40,000 teachers.
With a file from Bethany Lindsay, Vancouver Sun
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Equally lovely on both sides, our high thread count double face satin stands out with its bright, bold colors. It's elegant feel makes it an ideal choice for every occasion; including weddings and special events. Known for its high quality, you'll find this 100% polyester ribbon is colorfast and offers consistent coloring from spool to spool. It is machine washable and no ironing is required, so it is easy to use in fashion and décor projects.
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Hooray for the Rankings!
divThe following is cross-posted from SeeThruEdu.com, a new blog analyzing higher education:
Heaven knows there are oodles of problems with American higher education – and you'll get them all thoroughly dissected, diagnosed, and wellness plans delivered at SeeThruEdu – but I want to start my blogging here on a positive note. At least, a relatively positive note: American higher education is way closer to a free market than our moribund elementary and secondary system, and there's no better sign of that than the oft-maligned U.S. News and World Report college rankings released last week.
Just like higher education generally, the U.S. News rankings have huge problems. Heck, Emory University admitted to having sent inflated SAT and ACT scores, as well as class ranks, to the publication for years. As a result, in the latest rankings Emory moved…not one bit. The school stayed as number 20 among "national universities," and U.S. News apparently just accepted the data Emory submitted this time based on the school having "confirmed" them. More broadly, the rankings are based far more on inputs such as endowment funds, and dubious academic reputation surveys, than measures of what students actually learn.
But the good news isn't the perfection of the U.S. News rankings. It's what their very existence signifies: Higher ed consumers have real power, and institutions are sufficiently independent that they can both compete with one another and specialize in the needs of different students. It's why not only do the U.S. News rankings exist, they are essentially the magazine's flagship publication.
And college rankings are hardly restricted to U.S. News. Countless rankings and reviews are out there, giving prospective students and their parents myriad ways to slice and dice their options. No doubt the best of these – because of who's in charge of them – comes from fellow SeeThruEdu blogger, and higher ed gadfly extraordinaire, Richard Vedder, whose Forbes.com rankings assess schools using alumni success and costs. The Princeton Review will tell you where students have their noses most to the grindstone, or most obscured by beer-filled Solo cups. And the Associated Press just profiled two new entrants, one which ranks schools based on "revealed preference" – which schools students choose when accepted to multiple institutions – and one based on alumni satisfaction. And there are many, many more!
Unfortunately, part of the reason rankings are in such incredible abundance is that there is way too much consumer power in higher ed, if by power we mean money. Basically, students can demand all sorts of extravagant things (I need my massages and water park!) because third-parties – most notably the federal government – give them wads of cash to do so. Indeed, higher education is massively inefficient as a result of humongous subsidies both directly to schools and to students. But that will be the subject of many, far less giddy posts from me in the future. For now, a bit of a happy note: Hooray for the college rankings! Things in higher education could actually be worse!


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Fish and Game (Department of)
The California Department of Fish and Wildlife, together with the Fish and Wildlife Commission and the Wildlife Conservation Board, is responsible for managing the natural resources of fish and wildlife in California. The department enforces Fish and Wildlife Commission regulations, manages wildlife areas and ecological reserves acquired by the Wildlife Conservation Board, and administers programs to benefit the state's fish and wildlife resources. The department issues fishing, hunting, and other related licenses.
Complaint Jurisdiction
Violations of the Fish and Wildlife Code or the California Administrative Code sections pertaining to the Fish and Wildlife Commission.
Complaints Outside Jurisdiction:
Treatment of domestic animals or wildlife programs within the jurisdiction of local fish and Wildlife commissions or county boards of supervisors; availability of regulations for a particular hunting or fishing season before the opening day.
Department of Fish and Game
1416 9th Street, 12th Floor
Sacramento, CA 95814
(916) 445-0411
(916) 653-1856 Fax
To report poachers and polluters: (888) 334-2258
For information regarding DFG licenses consumers should contact their regional License Sales Office. A complete listing of regional offices can be found at the following website. www.dfg.ca.gov
Fishing and hunting license sales and regulations distribution:
License and Revenue Branch
1740 N. Market Blvd.
Sacramento, CA 95834
(916) 928-5805
(916) 419-7585 Fax
Directory of State Agencies Directory of Federal Agencies Return to DCA Home Page


text: It's time for another installment of Pot Psychology, the advice column in which everyone's problems are solved with an "herbal" remedy. (Remember, kids: Don't do drugs!) In this episode, the Hoda to my Kathie Lee, Rich, helps me dole out advice on stuff like death, balls, and hobos. Got a burning question? Send it to email@example.com with "Pot Psychology" in the subject line. (Please keep them short; they're verrrry hard to read when stoned.)


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Invicta Men's 23809 Subaqua Quartz Chronograph Gunmetal Dial Watch
Led with expert engineering, no feat or occasion will ever be too great for Invictas Subaqua to handle. The sheer magnitude of this mighty timepiece is superbly executed with surgical-grade stainless steel, Swiss movements and multiple color options of ionic plating. Managing up to 500 meters of water, finished off with a unidirectional rotating bezel, and integrated shock resistance- the Invicta Subaqua is the diver definitive in negotiating any adventure by land or by sea.
- Gender: Men
- Dial Color: Black
- Band Color: Black
- Band Material: Stainless Steel
- Case Type: Stainless Steel
- Case Tone: Black
- Case Diameter: 55.45
- Strap Size: 26mm
- Clasp Type: Fold over clasp with Safety
- Crown Type: Screw Down
- Water Resistant: 500m


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L-Carnitine to Treat Fatigue in AIDS Patients
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00079599
Recruitment Status : Completed
First Posted : March 10, 2004
Last Update Posted : September 4, 2008
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|HIV Infections AIDS
|Drug: L-carnitine Other: Placebo
|Phase 2
Fatigue is a commonly reported symptom in patients with end stage AIDS. Appropriate treatment can relieve suffering and improve quality of life. The role of progression of the disease, depression, anemia, and poor nutritional status in the development of fatigue is well recognized. However, the impact of micronutrient deficiencies has been minimally explored. AIDS patients are at risk for micronutrient deficiencies because of decreased caloric intake, increased metabolic requirements, and treatment with medications that can interfere with absorption, synthesis, and excretion. Patients with AIDS are particularly likely to be carnitine deficient.
Levocarnitine (L-carnitine) is a micronutrient found in meat and dairy products that plays a major role in energy metabolism. Preliminary research has shown that patients with end stage AIDS experienced decreased levels of fatigue after L-carnitine supplementation. This study will evaluate the effectiveness of L-carnitine to treat patients with carnitine deficiency, fatigue, and AIDS.
Participants in this study will be randomly assigned to receive either L-carnitine or placebo for 2 weeks. To reduce the possibility of side effects, the doses of L-carnitine and placebo will be titrated over 6 days to the desired study dose. After 2 weeks, participants receiving placebo will be switched over to receive L-carnitine. All participants will continue on L-carnitine for an additional 2 weeks.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|44 participants
|Intervention Model:
|Parallel Assignment
|Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
|Primary Purpose:
|Official Title:
|Phase II Developmental Study on Fatigue in AIDS Patients
|Study Start Date :
|November 2002
|Actual Primary Completion Date :
|March 2007
|Actual Study Completion Date :
|March 2007
|Experimental: 1
Drug: L-carnitine
A study drug, L-carnitine, titrating the doses from 0.5 g to 3 g to reduce the possibility of side effects, lasting for two weeeks followed by an extension phase where all patients recieved L-carnitine for an additional two weeks.
|Placebo Comparator: 2
Other: Placebo
A placebo, where patients underwent the dose titration identical to the study patients, lasting for two weeeks followed by an extension phase where all patients recieved L-carnitine for an additional two weeks.
- Level of fatigue, measured by the fatigue sub-scale of the FAHI [ Time Frame: Baseline; 2 weeks since starting L-carnitine or Placebo supplementation; 4 weeks (study termination) ]
- Changes in fatigue in the treatment and control groups [ Time Frame: Baseline; 2 weeks since starting L-carnitine or Placebo supplementation; 4 weeks (study termination) ]
- Changes in cognative status, mood, activity, and HGB levels mesured by BFI, LASA, KPS, and MSAS-SF [ Time Frame: Baseline; 2 weeks since starting L-carnitine or Placebo supplementation; 4 weeks (study termination) ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- AIDS at Stage IV-C and estimated life expectancy < 6 months
- Karnofsky Performance Score > 50
- Clinically significant, persistent fatigue
- If undergoing pre-existing treatment for fatigue, must have been on a stable regimen for at least 4 weeks prior to study entry
- Concurrent use of epoetin alfa (PROCRIT®) will be allowed if the patient has been on a stable dose of epoetin alfa for at least 60 days prior to study entry
Exclusion Criteria:
- Severe cardiovascular, pulmonary, or renal function
- Hemodialysis
- Treatment or replacement therapy with any form of carnitine within 12 months prior to study entry
- Known sensitivity to carnitine
- Acute illness within 30 days of study entry that in the opinion of the study investigator would interfere with participation
- Active drug or alcohol use or dependence
- History of any central nervous system disease involving the brain that may put the patient at risk for seizure (e.g., primary or metastatic brain tumor, stroke) or history of seizure
- History of dementia, aphasia, or other deficits of cognition or speech/language function
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00079599
|United States, New York
|Department of Pain Medicine and Palliative Care; Beth Israel Medical Center; First Avenue at 16th Street
|New York, New York, United States, 10003
|Principal Investigator:
|Ricardo Cruciani, MD, PhD
|Beth Israel Medical Center
|Responsible Party:
|Ricardo Cruciani, MD, PHD, Vice-Chairman, Department of Pain and Palliative Care, Director, Research Division, Beth Israel Medical Center
|ClinicalTrials.gov Identifier:
|NCT00079599 History of Changes
|Other Study ID Numbers:
1R21NR008295-01 ( U.S. NIH Grant/Contract )
|First Posted:
|March 10, 2004 Key Record Dates
|Last Update Posted:
|September 4, 2008
|Last Verified:
|September 2008
Carnitine Deficiency
Complementary Therapies
Signs and Symptoms


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Punk Bunny and the Flame
MUCH better than that useless piece of sh*t Sean Avery. And why hasn't he hooked up with Ebola Paris Hilton yet??? They deserve each other.
So Elisha Cuthbert has a thing for hockey players. After Sean there was supposedly a hook up with the Habs' Mike Komisarek, and now, I'm told it's Dion Phaneuf and everyone in Calgary will tell you…he's f*cking amazing.
Just signed 6 year contract reportedly worth over $6 million a year and he's only 22…one of the brightest young stars in the league. And his c*ck just got a little bigger. Because he's banging the girl next door.
Elisha has been spotted around Cowtown quite frequently of late, cheering on her man…made easier by the fact that she isn't exactly booked back to back. The career isn't so happenin' so much these days. Probably why I saw her making super nice with Jason Reitman at the Night Before Oscar party a few weeks ago.
Another victim of Ebola, see?
Hopefully, Calgary, for the sake of your hockey team, Elisha doesn't introduce Dion to the disease. Because if Ebola somehow manages to infect him, you can kiss your defence corps goodbye.


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Stearns and Foster
Stearns and Foster
Stearns and Foster Mattress - Big Savings on Stearns and Foster at Mancini's Sleepworld
Every Stearns & Foster mattress is built by only certified craftsman. The most experienced workers, held to the highest standards. Their work is constantly scrutinized to ensure perfection. And because of this detail-minded, hand-made crafting, each mattress takes twice as long to make as the average mattress. Everything from a stunning hand-tufted finish, styled handles, masterful embroidery and even a peek-a-boo fabric seen under the mattress are done by hand to attain rich luxurious looks and feels. To further the Stearns & Foster vision, only the finest materials are used.
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1971 imperorate edges VFU
1971 imperforate edges VFU (very fine used) with either one corner or the centre of stamp cancelled with a commercial cylindrical date stamp (stamps are never taken from first day covers). Pictures are for illustrative guidance only as the stamp you receive will be fine used.
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