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Bulldogs Enter Final Weekend Two Games Behind Crimson
Yale Game Notes | Harvard Game Notes | Dartmouth Game Notes
Yale Statistics | Harvard Statistics | Dartmouth Statistics
Yale Basketball On Facebook | Yale Basketball On Twitter
NBC Sports Network Channel Finder
Yale-Dartmouth Video: Ivy League Digital Network | Live Stats
NEW HAVEN, Conn. – It's the final weekend of the regular season and Yale remains alive in the race for the Ivy League title. The Bulldogs host first-place Harvard on Friday at 7:30 p.m. in a game that will be televised nationally on the NBC Sports Network. Yale then has a Saturday night date with Dartmouth on Senior Night. Tipoff is slated for 7 p.m. Jesse Pritchard, Jeremiah Kreisberg and Isaiah Salafia, Yale's three seniors, will be honored prior to the tip.
The Bulldogs (15-11, 9-3 Ivy) are two games behind Harvard. Yale needs to sweep the weekend and have Harvard lose at Brown on Saturday to earn a share of the Ivy title. Yale and Harvard would then meet the following week at the Palestra in Philadelphia to determine the league's automatic bid to the NCAA Tournament. Yale's last Ivy championship came in 2001-02 (three-way tie between Yale, Princeton and Penn). The Bulldogs haven't been to the NCAA Tournament since 1961-62.
It could also be a milestone weekend for James Jones, the Joel E. Smilow, Class of 1954 Head Coach of Men's Basketball at Yale, who enters the weekend with 205 victories, all during his time at Yale. Jones is one win away from tying Joe Vancisin as the school's all-time winningest men's basketball coach. Vancisin guided the Bulldogs to 206 wins from 1956 to 1975.
Sophomore Justin Sears has played a key role Jones' 15 wins this season. Sears, an Ivy League Player of the Year candidate, is among the league leaders in several categories, including scoring (3rd, 16.3 ppg.), rebounding (3rd, 6.8 rpg.), field goal percentage (7th, .495), steals (6th, 1.3 per game) and blocked shots (2nd, 1.9 per game). He has been named the Ivy League Player of the Week five times which is tied for second all-time for most player of the weeks in a season.
Start Strong –Quick starts in both games should only energize what should already be an amped up John J. Lee Amphitheater.
Finish Strong – Regardless of what happens on Friday, it's important for the Bulldogs to end the regular season on a high note if for no other reason than to send the three seniors out on a winning note.
Rebound – The Bulldogs controlled the glass (+11.0 rebounding margin) in sweeping Dartmouth and Harvard on the road last month. They will need a similar effort to do it again.
• After missing the Cornell-Columbia weekend with an ankle injury, Javier Duren returned and made a big impact on the two games last weekend. Against Princeton, he had 13 points, four assists and three steals, and in the win at Penn, he scored 14 points, including going 9-of-9 from the free throw line, and added six assists and two steals in 34 minutes.
• Nick Victor had a solid all-around game last Saturday against Penn, scoring six points, grabbing five rebounds, handing out three assists and adding three steals in 34 minutes.
Yale and Harvard have played some memorable games at the John J. Lee Amphitheater in recent years. In 2010, the Crimson escaped with an 82-79 victory in overtime. Harvard's Oliver McNally made 1-of-2 free throws with two seconds left to force the extra period. A year later, the Bulldogs exacted some revenge when Jeremiah Kreisberg's layup with 41 seconds left turned out be the winning basket in a 70-69 Yale victory that knocked Harvard out of first place. The teams went toe-to-toe again last year with the Crimson escaping with a 72-66 win. The score was tied at 56 with eight minutes remaining. Yale leads the all-time series 116-73, including a victory in the first meeting last month in Boston. The 116 wins are the most for Yale against any opponent. The Bulldogs have a chance to sweep the season series from the Crimson for the first time since 2008.
The Bulldogs have won 14 straight games over Dartmouth in Lee Amphitheater. Dartmouth's last win in the building was an 80-65 decision in 1999. Yale is looking to sweep the Big Green for the fourth time in the last five years. Brandon Sherrod scored 15 points to lead a balanced Bulldogs attack in a 67-54 victory in Hanover, N.H., last month. Yale leads the all-time series 108-95.
The Crimson (24-4, 11-1 Ivy) has already clinched at least a share of the Ivy League title. It is the fourth straight year Harvard has won at least a share of the Ivy crown. The Crimson's 24 wins are the second most in program history, trailing only the 26 victories posted by the 2011-12 squad. Harvard has six players averaging at least 9.4 points, led by Wesley Saunders at 14.0 ppg. Siyani Chambers, who averages 11.0 points and has a team-best 129 assists, is a 2014 Bob Cousy Collegiate Point Guard of the Year Award Watch List Finalist.
The Big Green (10-16, 3-9 Ivy) plays at Brown on Friday. Alex Mitola (11.0 ppg) and Connor Boehm (10.6 ppg.) lead Dartmouth in scoring. Mitola has a team-best 58 three-pointers. The Big Green is coming off an 87-78 victory over Cornell last Saturday. Mitola scored a career-high 33 points to lead the way. Dartmouth will almost undoubtedly end up with more rebounds than its opponents this year. It has been 27 years since the Big Green finished a season with a positive rebound margin.
Report filed by Tim Bennett, Yale Sports Publicity


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Where the Rubber Meets the Road
But outside of our tight little audiophile community, high-end audio is virtually unknown—I'm sure at least 98 out of 100 of the Carnegie Hall or Blue Note jazz club faithful are clueless about even the most prominent high-end brands. To succeed, those companies must not only produce great-sounding products and earn positive reviews, they must also rely on an active dealer network to reach most of their customers—folks who never read an audio or home-theater magazine but appreciate the difference a superb system can make. The dealer is the all-important link between audiophiles and "civilians" and the manufacturers.
To learn more about high-end retailers' modus operandi, I met with three of New York City's key players: Michael Kay of Lyric Hi-Fi & Video, Andrew Singer of Sound by Singer, Ltd., and Elliot Fishkin of Innovative Audio Video Showrooms. These retailers have not only survived countless bear markets and upheavals in the high-end industry, they've prospered. I met with each man, armed with the same set of questions, and as you'll see, they have very definite opinions about where the high-end industry is and where it's going. I'd worked as a salesman for both Singer and Fishkin, but I'd had little interaction with Lyric's owner, Michael Kay, and so began my interview sessions with him.
These interviews took place in late August, before the horrific attacks of September 11, 2001.

subset: commoncrawl


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Top Items:
Wall Street Journal:
Microsoft Is in Talks To Buy Facebook Stake — SAN FRANCISCO — Microsoft Corp. is in talks with Facebook Inc. about making an investment in the social-networking startup that could value Facebook at $10 billion or more, according to people familiar with the matter.
Discussion: Silicon Alley Insider, CenterNetworks, Reuters, paidContent.org, mathewingram.com/work, GigaOM, IP Democracy, Webware.com, Read/WriteWeb, HipMojo.com, Andy Beal's Marketing Pilgrim, TechCrunch, 24/7 Wall St., Search Engine Land, FaceReviews.com, Greg Galitzine's VoIP …, Valleywag, IP Telephony, VoIP, Broadband, The Viral Garden, Clickety Clack, All Facebook and ResourceShelf
Allen Stern / CenterNetworks: Microsoft Looking to Buy 5% of Facebook
Staci D. Kramer / paidContent.org: Microsoft Negotiating For Equity Stake In Facebook: Report
Om Malik / GigaOM: Microsoft Wants A Piece Of Facebook?
Cynthia Brumfield / IP Democracy: Is Facebook Worth $10 Billion?
Caroline McCarthy / Webware.com: REPORT: MICROSOFT PLANS TO INVEST IN, NOT ACQUIRE, FACEBOOK
Ashkan Karbasfrooshan / HipMojo.com: MSFT/Facebook Rumor Creeps Back Up Again: Will it Help or Hurt Facebook?
Jordan McCollum / Andy Beal's Marketing Pilgrim: Rumor Mill: Microsoft Buying a Stake in Facebook
Michael Arrington / TechCrunch: Microsoft May Invest in Facebook At $10 Billion Valuation
Barry Schwartz / Search Engine Land: Microsoft May Buy $10 Billion Stake In Facebook
Rodney Rumford / FaceReviews.com: Microsoft and Facebook Business Connection Strengthens
Russell Shaw / IP Telephony, VoIP, Broadband: Poll: With Microsoft now talking to Facebook, who should buy them?
Mack Collier / The Viral Garden: Facebook worth $10 billion?
Junior Hines / Clickety Clack: Microsoft Wants To Buy A Piece Of Facebook
Nick O'Neill / All Facebook: Microsoft to Invest in Facebook
Larry Dignan / Between the Lines:
Microsoft reportedly eyeing Facebook stake — Microsoft is eyeing an investment in Facebook that would value the social networking company at about $10 billion. — The investment, which was reported by The Wall Street Journal citing "people familiar with the matter, connects a few dots on the social networking landscape.
Discussion: InfoWorld and alarm:clock
Juan Carlos Perez / InfoWorld: Report: Microsoft seeks Facebook stake
Louise Story / New York Times:
Company Will Monitor Phone Calls to Tailor Ads — Companies like Google scan their e-mail users' in-boxes to deliver ads related to those messages. Will people be as willing to let a company listen in on their phone conversations to do the same? — Pudding Media, a start-up based in San Jose …
Terrence Russell / Epicenter: Pudding Media Raises Privacy Concerns by Monitoring VoIP Calls
John Paczkowski / Digital Daily: Guess 'Puddin' Head Media' Was Already Trademarked, Huh?
Shelly Palmer / MediaBytes with Shelly Palmer Video: MediaBytes - 09.24.07 — Click to view today's MediaBytes video.
Henry Blodget / Silicon Alley Insider:
Today's Terrible Idea: Pudding Media — A new start-up called Pudding Media is offering free PC-based telephone calls—if users allow the company to listen in on their conversations and serve targeted ads based on what they're talking about (NYT). This is one of the worst business ideas we've heard …
Cynthia Brumfield / IP Democracy: Just Say No to Pudding Media — In what Henry Blodget deems …
John Murrell / Good Morning Silicon Valley: ThePudding? More like Wiretapioca
Erica Ogg / Webware.com: THE PUDDING: EAVESDROPPING TO SELL YOU STUFF
Mark Hendrickson / TechCrunch: ThePudding: Targeted Advertising Comes to Phone Calls
Jason Lee Miller / WebProNews: The Privacy Is In The Pudding (Or Not)
Dennis Bouchand / 901am: Pudding Media delivers free calling by delivering fun, entertaining …
Mark Hachman / AppScout: Would You Like Advertisers Listening to Your Calls?
Joel Durham Jr / ExtremeTech: Ad Software Listens In to Internet Phone Calls
Junior Hines / Clickety Clack: Algorithms Grab The Spotlight
Russell Shaw / IP Telephony, VoIP, Broadband: New service would display ads based on keywords you say in phone calls
Zac Bissonnette / BloggingStocks: Big brother: Company to listen in on phone calls to target ads
Andy Abramson / VoIP Watch: Henry Blodgett on Pudding
Om Malik / GigaOM:
The Mad Ad World & Cheap Calls — Technology business often goes through periods where rationality and reality are suspended. We just might be in that phase, and nothing highlights that than the launch of ad-supported phone services. In UK, Blyk, an ad-supported mobile service we wrote about eons ago launched.
Discussion: Search Engine Land and TechCrunch
Mike Butcher / TechCrunch: Blyk launches ad-based mobile network
Peter Svensson / Associated Press:
New service eavesdrops on Internet calls
New service eavesdrops on Internet calls
Discussion: Newlaunches.com, Gizmodo, dslreports.com, CrunchGear, ReveNews Online Revenue … and The Raw Feed
Wilson Rothman / Gizmodo: VoIP: ThePudding.com Phone Service Listens to Your Calls, Makes You Watch Ads
Karl / dslreports.com: 'The Pudding' Listens In On VoIP - And displays context-sensitive advertisements...
Peter Ha / CrunchGear: Your VoIP Calls Are Being Tapped
Sam Harrelson / ReveNews Online Revenue News …: Contextual Advertising: How Far Is Too Far and What if Google Goes Evil?
Mike Masnick / Techdirt:
'Free, With Ads' Phone Calls Trying Yet Again
'Free, With Ads' Phone Calls Trying Yet Again
Discussion: Geek News Central
Matthew / Geek News Central: Maybe ad supported food?
Jonathan Fildes / BBC:
'$100 laptop' to sell to public — Computer enthusiasts in the developed world will soon be able to get their hands on the so-called "$100 laptop". — The organisation behind the project has launched the "give one, get one" scheme that will allow US residents to purchase two laptops for $399 (£198).
Discussion: Read/WriteWeb, The Browser, Cinema Blend Feeds, Daggle, broadstuff, Wikinomics, Guardian Unlimited, Between the Lines and Mashable!
Josh Catone / Read/WriteWeb: Selling OLPC Laptops in USA - Good Idea?
Oliverryan / The Browser: A better alternative to One Laptop per Child?
Danny Sullivan / Daggle: $100 Laptop? Don't Wait — Get Yours Now
Dan Herman / Wikinomics: Tech solutions to under-development.
Jack Schofield / Guardian Unlimited: Buy one, give one away — OLPC for everyone
Larry Dignan / Between the Lines: OLPC to offer two-packs to jump start sales
Pete Cashmore / Mashable!: $100 Laptop: Get Your Own!
Steve Lohr / New York Times:
Buy a Laptop for a Child, Get Another Laptop Free — One Laptop Per Child, an ambitious project to bring computing to the developing world's children, has considerable momentum. Years of work by engineers and scientists have paid off in a pioneering low-cost machine that is light, rugged and surprisingly versatile.
John Murrell / Good Morning Silicon Valley: One Laptop Per Child issues pitch to fix slow boot sequence
Marius Chitosca / Smart Mobs: "Buy a Laptop for a Child" Project going steady
Carolyn Y. Johnson / Boston Globe: Building a critical mass
Jessica E. Vascellaro / Wall Street Journal: Laptop Charity Seeks Help From Home Market
Nick Mokey / Digital Trends: OLPC XO-1 Goes On Sale to Public
Scott Gilbertson / Compiler: OLPC Laptops Available In The U.S. With "Give One Get One" Program
Cynthia Brumfield / IP Democracy: One Laptop Per Child Aims for the Heart
Jeremy Kirk / InfoWorld:
Virgin drops Windows Media-based music download service — San Francisco (IDGNS) - Virgin Group Ltd. will shut down its online music subscription and download service in the U.S. and U.K. next month, leaving one less competitor for Apple Inc.'s iTunes Music Store.
Discussion: Ars Technica, Download Squad and Infinite Loop
Jacqui Cheng / Infinite Loop: Starbucks to spread 50 million pieces of iTunes love
Associated Press:
Starbucks to Give Away 50 Million Songs
Starbucks to Give Away 50 Million Songs
Discussion: Engadget, Gizmodo, Yahoo! News, Gadget Lab, Orbitcast, Newlaunches.com, The Globe and Mail, ExtremeTech and Ubergizmo
Wilson Rothman / Gizmodo: Apple: Starbucks To Start Up iTunes Wi-Fi Store with 50 Million Free Songs
Charlie Sorrel / Gadget Lab: Starbucks 50 Million Song Giveaway
Mathew Ingram / The Globe and Mail: Pay $5 for a coffee, get a free song
Joel Durham Jr / ExtremeTech: Starbucks to Give Away iTunes Tunes
Candace Lombardi / CNET News.com:
Think tank to EU: Unbundle Windows on PCs — The Globalization Institute, a Brussels-based EU think tank, has recommended the European Union require all PCs to be sold without pre-loaded operating systems such as Microsoft Windows. — There is no reason why computer operating systems …
Discussion: TECH.BLORGE.com and Macsimum News
Jonathan Schlaffer / TECH.BLORGE.com: Globalization Institute wants EU to unbundle Windows with PCs
Dennis Sellers / Macsimum News: Globalization Institute: 'unlock' PCs from Windows
Ted / Ted's Take:
"PayPal Meets MasterCard" Without The High Fees — MEDIA CONTACT: — Brad Burns — 202-776-1400 — firstname.lastname@example.com — REVOLUTION JOINED BY INDUSTRY LEGENDS AND MAJOR BANKS TO LAUNCH REVOLUTIONARY PAYMENT SYSTEM — Steve Case, Ted Leonsis, Larry Summers, David Pottruck …
Discussion: paidContent.org and Mashable!
Joseph Weisenthal / paidContent.org: Steve Case, Ted Leonsis Launch Online Credit-Card Firm Revolution …
Adam Ostrow / Mashable!: Steve Case Launches Free Money Transfer Service
James Kendrick / jkOnTheRun:
We need a real handheld computer, who will build one? Apple of course — It's a great time to be a handheld PC enthusiast, not because there are so many good devices to choose from, because I don't think there are, but because public awareness of handheld PCs are at an all-time high.
Discussion: Channel 9 and GottaBeMobile.com
Warner Crocker / GottaBeMobile.com: Slip Sliding Away
Adam Frucci / Gizmodo:
Military: Lockheed Martin Developing 'Maple Seed' Flying Cameras — The Pentagon is giving the war profiteers over at Lockheed Martin a nice chunk of change to develop a spy camera modeled after a maple seed. Loaded up with two rockets, the wee, single-winged camera would be used …
Discussion: Crave, Gadget Lab, Ubergizmo and The Raw Feed
Will Greenwald / Crave: The gadget blog: The trees have eyes — Military and spy tech just keeps getting weirder and weirder.
Rob Beschizza / Gadget Lab: Lockheed Martin's Spy Seed
Prince McLean / AppleInsider:
Updated Leopard requirements to exclude 800MHz systems — Just weeks ahead of its public launch, Apple Inc. has updated the minimum system requirements for its next-generation Leopard operating system to exclude 800MHz PowerPC-based Macs, AppleInsider has learned.
Discussion: Byte of the Apple, Compiler, CrunchGear, Gizmodo, The Unofficial Apple Weblog and Ubergizmo
Arik Hesseldahl / Byte of the Apple: So Long PowerPC — It had to happen sometime, and it looks …
Scott Gilbertson / Compiler: Rumor: OS X Leopard Nears Completion
Vince Veneziani / CrunchGear: Leopard To Exclude Legacy Apple Systems?
Wilson Rothman / Gizmodo: Apple: 800MHz G4 Macs Are Dead to Leopard
Dave Caolo / The Unofficial Apple Weblog: Leopard to exclude 800MHz systems
TDavid / Things That:
Tablet PC users will like Sketchcast for non-commerical usage — The first thing I thought of was the Tablet PC when I saw Sketchcast as a delicious popular post in my RSS reader this morning. With Sketchcast you can share drawings with or without voice all through a pen-friendly Flash interface in the browser (Firefox or IE).
Discussion: CenterNetworks, CyberNet Technology News, TechCrunch and Google Blogoscoped
Michael Arrington / TechCrunch: Sketchcasting - Another Weapon In The Blogging Arsenal
Philipp Lenssen / Google Blogoscoped: New: Sketchcast.com — When Rich Ziade came up with the idea …
Duncan Riley / TechCrunch:
Pownce vs Digg: Who Will Kevin Rose Back? — I've speculated previously on the growing conflict Kevin Rose has between his roles at Digg and Pownce, and now it would appear that we may finally be on the eve of Rose being forced to decide between the two. — Leah Culver, a co-founder …
Discussion: Valleywag, WebProNews, mathewingram.com/work, Pronet Advertising and Mashable!
David A. Utter / WebProNews: Digg, Pownce Have Gender Issues
Muhammad Saleem / Pronet Advertising: Don't Spread Yourself Too Thin
Adam Ostrow / Mashable!: Pownce Co-Founder Upset Over New Digg Features
Doug Aamoth / CrunchGear:
Who Else Got Burned By An 'End Of Summer' Promise? — Long Zheng of istartedsomething.com is mad. So am I, although not quite about the same thing. Zheng is brassed off that the Windows Ultimate team hasn't delivered DreamScene (basically, the ability to use a video file as your desktop background) …
Discussion: InfoWorld
Matt Marshall / VentureBeat:
Tubes, offering Web site editing offline, now works on mobile — Tubes, a service that lets you recreate entire Web sites for viewing and editing offline, has launched with new mobile features. — Tubes, based in Boston, is useful because many people like to work offline — for example on planes …
Discussion: Mashable!
Sean P. Aune / Mashable!: Tubes Announces RC2 and The Hub


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FIFA Street 2
What do you need help on? Cancel X
FIFA Street 2 is second installment in EA's four-on-four soccer game. FIFA Street 2 will feature improved controls, many more tricks, and a new juggle mechanic. Take part in game modes, such as friendly, rule the street, and skills challenge. Choose from 20 national teams and 300-plus real-life soccer stars. There are 10 playable venues ranging from London's Westway Leisure Center to the sandy beaches of Brazil.
Game News
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2 Users
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WoodWing Enterprise 8.1 Simplifies Multi-Channel Publishing
By: Press Release | WoodWing
WoodWing has released version 8.1 of its publishing system Enterprise, offering further optimizations to multi-channel workflows. Content Station and InDesign have also been integrated more tightly.
Users of WoodWing Enterprise 8.1 and its editorial management application Content Station will benefit from enhanced usability and efficiency. The Content Station multi-channel text editor now features a visual mode that displays various forms of text formatting. Thanks to this, copywriters will get a realistic look at how their articles will appear on the Web or in the final print layout – even when InDesign Server is not being used.
Users will also appreciate a new panel in InDesign that shows all dossiers related to the current layout. As WoodWing dossiers correspond to the individual stories on the layout, this offers quick access to the assets that belong to these stories. Content Station can also now be used to conveniently place files onto an InDesign layout via drag-and-drop.
Easy animations and improved support for alternate layouts
For Digital Publishing users, WoodWing has simplified the creation of animations through one of its Widgets. Using the new Widget snapshot feature, designers can select a frame on their page that contains an image or text and turn it into an animation. The frame can be animated based on various parameters, such as effects and duration. Additional Digital Publishing improvements include enhanced support for alternate layouts.
2013 will be a busy year for WoodWing´s development team
"We constantly strive to offer our customers the best multi-channel publishing environment," said Erik Schut, President of WoodWing Software. "We help them address the challenges they are facing, especially in terms of efficiency and profitability. You can expect a number of additional significant steps along this path this year."
"Further development of WoodWing's Digital Asset Management solution Elvis DAM is also a key point on the roadmap for 2013," Schut added. "On top of that, WoodWing will continue to expand its collection of Digital Publishing Widgets, helping users at any level of expertise to easily add great interactivity to their digital publications."
Version 8.1 of WoodWing's publishing system is available via the WoodWing community site.


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Cairns Airport
OpenRegister ▻
Deferral Program
Athletes who register for 2020 IRONMAN Cairns or 2020 IRONMAN 70.3 Cairns on or before 11.59pm, September 15, 2019 are eligible to defer their entry into the corresponding 2021 event free of charge. All deferral requests will be honoured until 11.59pm, April 23, 2020 regardless of the reason for deferral. The deferral may only be used once. Athletes who elect to defer their entries forfeit any partial refund or insurance refund. Deferrals are only available for individual entries and not for relay teams.
Payment Plan Option (only available for 2020 IRONMAN Cairns)
Athletes who register for 2020 IRONMAN Cairns on or before 11.59pm September 15, 2019 may elect to pay via a three-part payment plan. Athletes will be charged three instalments. To elect the payment plan, an athlete needs to register under the "Payment Plan" category during the first 90 days of general entries being available and make the initial payment. All three payments must be completed for an athlete to race – partial payments will not be refunded or honoured as race entries. Athletes electing the payment plan may also utilize the deferral option or transfer option once all three payments have been completed. *NOTE: Payment Plan Option will use tier 3 pricing. In the event that general entry pricing moves to tier 4, payment one of the payment plan will increase to reflect tier 4 pricing.
Tiered Pricing
2020 IRONMAN Cairns and 2020 IRONMAN 70.3 Cairns will also offer tiered pricing based on entry allocation rather than dates. Once allocations are exhausted at each level the price will go up.
|Tier 1 - $805.80
|Tier 1 - $372.30
|Tier 2 - $841.50
|Tier 2 - $392.70
|Tier 3 - $877.20
|Tier 3 - $413.10
|Tier 4 - $912.90
|Tier 4 - $433.50
|Please note the above prices do not include the 8% active fee.
Entry Opening Timings
|Entries Open
|AWA Members
2019 IRONMAN Cairns participants
2019 IRONMAN 70.3 Cairns participants
|Monday, June 10, 2019 - 11am AEST
|TriClub members
|Wednesday, June 12, 2019 - 11am AEST
|General online entries open
|Monday, June 17, 2019 - 11am AEST


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Line Series
Archival Pigment Print, 2009
Line Series #17 (Archival Print)
from 36.00
Archival Pigment Print, 2009
Printed on 100% Acid-Free Cotton Rag Paper
With Archival Inks
Signed & Numbered by Artist
Ready-to-Frame Sizes
Limited Editions of 25
This piece is a reproduction of an original screenprinted monoprint from a series that makes use of five films of various line weights and textures to explore unlimited variations in color, transparency, frequency and order. The screens from this series were repurposed for a limited edition run of hand-printed textiles available here.
* View original art for sale from this series.
Size/Framing Option:


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New to Bullseye? Subscribe to our podcast in iTunes or with your favorite podcatcher to make sure you automatically get the newest episode every week.
And if you're looking for a particular segment to listen to or share, check us out on Soundcloud.
In the early 1990s, the hip hop group Digable Planets broke through with their single "Rebirth of Slick (Cool Like Dat)". The single was jazzy and laid-back, and became a crossover hit. The trio were pegged by some as a counterpoint to gangsta rap, but they didn't love the efforts to categorize their sound. They went further on their next boundary-pushing release, the classic record Blowout Comb. The album was critically acclaimed, but didn't sell well, and the group drifted apart shortly afterward.
Founding member Ishmael Butler was only in his mid 20s when Digable Planets broke up. And so he tried other things, like filmmaking. He still made music, but the releases were few and far between. About five years ago, he teamed up with Tendai Maraire to form a new group called Shabazz Palaces.
Shabazz Palaces' new release is called Lese Majesty, and it expands on their interstellar sound.
Butler spoke to us about his days as a indie label gopher, the awkward audition Digable Planets had to endure for a record company executive, and the the transformative sounds of Shabazz Palaces.
Is there still good pop-punk out there? What's the musical equivalent of a drunk text? Music critic Todd Martens of the Los Angeles Times stops by to answer both of those questions!
He recommends a listen to two new albums: the Muffs' first release in ten years, Whoop Dee Doo, and a new record from Chicago garage rockers Twin Peaks called Wild Onion.
You can find Todd's writing in the LA Times and on their blog, Pop and Hiss.
There's a certain kind of feeling to the director Michel Gondry's films. A little bit of happiness mixed with sadness. Nostalgia for something that you experienced, or maybe something you wish you had experienced. You may have felt it watching Eternal Sunshine of the Spotless Mind, The Science of Sleep, or his new film Mood Indigo.
For "The Song That Changed My Life", Gondry describes the feeling of saudade and how he felt watching Nico Ferrer perform the song "Le Sud" on a Saturday night.
Gondry's new film Mood Indigo is a fantastical story of love and loss, starring Audrey Tatou and Romain Duris. You can find it in theaters now.
If you've seen Allison Janney on television lately, it's been in one of two very different roles. On the Showtime series Masters of Sex, Janney guest stars as a somewhat naive, vulnerable 1950s housewife who experiences a breakthrough after many years in a sexless (but not loveless) marriage. Her story is both heartbreaking and hopeful. In the CBS sitcom Mom, she plays Bonnie, a recovering alcoholic who's outrageous, biting, and very funny. Bonnie's been down, but she's making peace with her estranged daughter and getting her life back together. Janney's characterizations are versatile; they allow her to be warm, steely, confident, and thin-skinned by turns. Janney is currently nominated for Emmys for both roles; 'Outstanding Guest Actress in a Drama' for Masters of Sex, and 'Outstanding Supporting Actress in a Comedy' for Mom.
She spoke to us about her early acting days (including auditioning for an intimidatingly handsome Paul Newman), getting comfortable with the inevitable nude scenes for Masters of Sex, and the ways that her mom's background and brother's struggle with addiction gave her insight and empathy for her current roles.
Jesse explains why the last Hollywood picture Orson Welles directed, Touch of Evil, tells us so much about Welles as an artist.


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DURHAM, N.C. – Following an ACC dual meet Friday evening against nationally-ranked Virginia, the Duke women's swimming and diving team returned to the pool in strong form Saturday afternoon, defeating the Richmond women by a score of 160-131. With the win, the Blue Devils improved to 4-3 overall heading into next weekend's regular season finale against North Carolina.
On the day, Duke totaled wins in eight individual events and took first in both relays.
"Credit goes to the ladies on having great energy and determination," said head coach Dan Colella. "From start to finish, they were just really engaged and did an absolutely great job today … I was very proud of the way they came in and were able to perform this afternoon after swimming the way they did last night."
Freshman Brittany Friese paced the squad individually with first-place finishes in the 200-yard butterfly (2:04.39) and the 500 freestyle (5:07.76). Fellow rookie Jessie Sutherland led a one-two-three-four finish for the Blue Devils in the 100 backstroke, touching first at 57.13 with sophomore Megan McCarroll taking second (57.85), graduate student Francesca Tocci third (57.92) and sophomore Kathryn Eckhart fourth (58.27).
The Blue Devil sprinters had another impressive outing Saturday, sweeping the top three spots in the 50 and 100 freestyle. Senior Lauren Weaver won the 50-yard race with a 23.46 clocking, followed by sophomore Chelsea Ye (24.21) and senior Kelly Hagerty (24.32). Ye and Hagerty were also second and third, respectively, at the 100-yard distance, with freshman Maddie Rusch taking first at 51.83. Senior Christine Wixted added a win in the 200 breaststroke, while graduate student Emily Barber was second in the 100 breaststroke.
In diving, freshman Kirby Quinn collected her second win of the season on the 3-meter springboard, earning a personal-best award of 333.15. Sophomore Kendall McClenney came in second with 275.70 points, and was also second on the 1-meter board at 263.40.
After edging the Cavaliers Friday night in the 200 freestyle relay, the Duke women had more success in the relay events Saturday against the Spiders. The Blue Devils swept the top two places in the 200 medley relay, with Sutherland, Wixted, Rusch and Weaver placing first at 1:43.51 and McCarroll, Barber, sophomore Linsay Cooper and Ye following in second at 1:45.33.
The final event of the day saw the team of Rusch, Ye, Sutherland and Weaver combine for a time of 1:33.80 to win the 400 freestyle relay as well.
"We knew that we had to come in hard for the Spiders," Ye said. "With all of us combined, it was really easy to get pumped and ready to race."
The Duke men and women will be back in Taishoff Aquatic Pavilion next weekend, hosting North Carolina in the Blue Devils' regular season dual meet finale Saturday, Feb. 1 at 11 a.m. The program will honor its senior class prior to the beginning of the meet.
Press release courtesy of Duke University.
Full results.


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Here's an odd comment from Google CEO Larry Page on Steve Jobs' rage over Android.
He gave an interview to Bloomberg BusinessWeek's Brad Stone to commemorate his one year anniversary as CEO.
At the end, Stone asks, "According to the Steve Jobs biography by Walter Isaacson, when you became CEO you went to Jobs for advice. I know you had your differences at the end around Android, but what did you take from him as a mentor and a friend?"
And here's what Page said in response:
I think the Android differences were actually for show. I had a relationship with Steve. I wouldn't say I spent a lot of time with him over the years, but I saw him periodically. Curiously enough, actually he requested that meeting. He sent me an e-mail and said, "Hey, you want to get together and chat?" I said, "Sure, I'll come over." And we had a very nice talk. We always did when we had a discussion generally. He was quite sick. I took it as an honor that he wanted to spend some time with me. I figured he wanted to spend time with his family at that point. He had a lot of interesting insights about how to run a company and that was pretty much what we discussed.
Stone interrupts and asks: Wait, the fury around Android was for show?
Page responds:
I think that served their interests. For a lot of companies, it's useful for them to feel like they have an obvious competitor and to rally around that. I personally believe that it's better to shoot higher. You don't want to be looking at your competitors. You want to be looking at what's possible and how to make the world better.
Get the latest Google stock price here.


text:
While we've come up with ingenious methods of escaping avalanches, science still isn't well-versed in their inner mechanics. A Montana State University researcher is trying to change that by setting off his own mini-avalanches—just, you know, indoors.
Engineering professor Ed Adams performs his research out of the Subzero Science and Engineering Research Facility at MSU. The 2,700 square foot lab has been in operation since 2008, making it one of the most state-of-the art facilities of its kind.
Adams is researching the effects of radiation recrystallization when deeper snow get warmer than the powder on top and creates instability in the snow pack. For his experiments, Adams "grows" snow in specialized, -5-degree cold rooms that house small 65-degree pools of water. He blows air over the water, channeling the vapor up a chimney, and through an array of strings that collect and crystallize the vapor.
The ice crystals are then harvested and transported to an Environmental Chamber—one with a refrigerated ceiling that mimics natural snow fall. Why? Because "Once snow gets on the ground, it's in an ongoing state of change," Adams told Popular Science.
To mimic the radiation recrystallization, he warms the snow with lamps, then slices it in half lengthwise, sets marker spots that can be followed by a modelling program. He'll then add greater and greater loads until the snowpack cracks.
This may seem like a strange way to learn about avalanches but it certainly beats Adams' previous method. He used to tie a reinforced shed to a boulder on the side of a mountain, then set off explosives on the hill above, causing an avalanche, burying the cabin, and allowing him to study the snowpack. [PopSci - MSU]
Image: Galyna Andrushko / Shutterstock


text:
- Championship Central
- Video Highlights
BALTIMORE – The UMBC women's soccer team capped off a Cinderella turnaround, going from last in the conference last season, to capturing a share of its first-ever regular season title. Sophomore back Nikki Boretti (Crofton, Md./Archbishop Spalding) and junior midfielder Lilly Rydon (Stirling, South Australia/Concordia College) scored 53 seconds apart to complete the 2-1 come-from-behind victory against New Hampshire in Sunday afternoon's regular season finale at Retriever Soccer Park. The Retrievers will make their first postseason appearance since 2005, as the No. 1-seed in the America East Championship.
The Retrievers conclude the regular season by matching their highest win total in program history, finishing with an 11-5-2 overall mark and a 6-2 record in the league play. UMBC becomes the first team in America East history to earn a regular season title after finishing last in the conference the season before. New Hampshire (4-8-6, 2-4-3 AE) misses out on postseason play with the loss.
After a scoreless first half, the Wildcats took a 1-0 advantage in the 49th minute as senior midfielder Kristi Zarrilli lofted a ball over the top and sophomore back Kirsten O'Neil punched in a shot under UMBC goalkeeper Lauren Kadet (Oakville, Ontario/St. Thomas Aquinas).
Moments later, Kadet kept it at a one-score game, picking up one of her six saves on a header from three yards out by O'Neil.
For the second straight game, the Retrievers waited until there was less than 10 minutes left in the game to ignite their comeback. Although UMBC was unable to take advantage of its first of two corner kicks within 20 seconds, junior back Melissa Hummel (Downingtown, Pa./Downingtown East) sent a long ball that Boretti was able to head in for her first-career goal.
A free kick less than a minute later setup the sequence for the game-winner, as Hummel sent in a cross that was knocked out by a Wildcat defender. Freshman forward Amanda Dailey (Howell, N.J./Freehold Township/Monmouth) headed the ball to red-shirt junior midfielder Jessy Brown (Plantation, Fla./American Heritage), who headed it towards the net for the Rydon tip-in in the 84th minute.
The Retrievers solidified the first seed in the tournament with Stony Brook's 2-1 double overtime victory against Maine. With Stony Brook and UMBC tied with 18 points apiece during conference play, each captured a share of the title, with UMBC taking the top spot in the tournament due to its head-to-head victory against the Seawolves on Oct. 17.
UMBC earned a bye during quarterfinal action and will host the winner of No. 4 Hartford and No. 5 Vermont on Sunday, Nov. 3 at 1 p.m. at Retriever Soccer Park.
Game Notes
-UMBC earns just its second victory against the Wildcats in 11 tries.
-The Retrievers will make their third appearance in America East Championship action, but will be looking for their first postseason victory since joining the league.
-After posting a 1-11-5 record last season, UMBC is in the top-three in the nation in winning percentage turnarounds, a difference of .461.


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Medicine for Tourette's Disorder
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Topic Overview
Medicine is generally not needed for Tourette's disorder (TD). Usually doctors first work with parents and other caregivers (such as teachers) to educate them about the condition. Behavioral training, such as habit reversal training, creating an appropriate home and school environment, and helping build your child's self-esteem are often tried first.
Sometimes medicines are added to a treatment program when tics are severe or are causing your child a lot of physical, mental, or emotional problems. The goal of using medicine for tics is to improve a child's overall functioning, not to make the tics go away completely.
An overall program that includes medicine may ease a child's general frustration and make him or her more comfortable around other people. Medicine sometimes helps a child with TD feel better mentally and function better at school and at home.
It is important to find out whether a child with TD also has symptoms of other conditions, such as behavior problems or mood disorders. Often problems such as depression or anxiety need to be treated first.
In the United States, treating tics with medicine is often an unlabeled use . This means that the U.S. Food and Drug Administration (FDA) has not approved the medicine specifically for treating tics or has not approved it for use in children. If a doctor suggests that your child take medicine to control tics, ask for an explanation of the benefits and risks. Ask how the medicine works, how long your child can take it, and whether there are any short-term or long-term side effects.
It is sometimes difficult to know whether medicine is helping to control tics. This is because the tics in Tourette's disorder can come and go. Also, tics may return or seem worse when medicine is stopped. Always work with a doctor when you want your child to start or stop taking medicine.
Medicines may target tics or symptoms of associated disorders, such as obsessive-compulsive disorder .
Medicines to treat tics include:
- Clonidine (Catapres), which has been shown to reduce tics by 25% to 35% over 8 to 12 weeks. footnote 1 Known side effects include drowsiness and low blood pressure. It's important to check your child's blood pressure and pulse both at the start of treatment and during it. People who have heart conditions should talk with a doctor about whether they can take clonidine.
- Risperidone (Risperdal) or aripiprazole (Abilify) may be used if other medicines do not help.
For safety, it is important that your child's doctor know about all the medicines your child is taking.
Botulinum toxin (Botox) is sometimes used as a short-term treatment for severe tics. The medicine is given as an injection (shot) into the area where tics occur frequently, such as the vocal cords, neck, face, arms, or legs. The medicine's effects typically last about 3 or 6 months. footnote 2 In rare cases, serious side effects can occur. Talk to your child's doctor about the risks and benefits of this medicine.
Other medicines are being studied as possible treatments for tics.
Medicines commonly used to treat symptoms of other disorders that are frequently associated with TD include:
- Guanfacine (Tenex), which may be used to treat attention deficit hyperactivity disorder (ADHD) .
- Risperidone (Risperdal) and olanzapine (Zyprexa), which may be used to treat mental health problems, such as bipolar disorder .
Medicines to treat a child for ADHD when the child also has Tourette's disorder
Many doctors consider it safe to give medicines to treat attention deficit hyperactivity disorder (ADHD), with a few exceptions, to children who also have TD. Although high doses of stimulant medicines have been reported to increase tics in some children, controlled research suggests that most children's tics do not get worse with these medicines. And some stimulant medicines have been shown to improve tic symptoms. footnote 3
Related Information
- Bloch MH, Leckman JF (2007). Tic disorders. In A Martin, FR Volkmar, eds., Lewis's Child and Adolescent Psychiatry, 4th ed., pp. 569-583. Philadelphia: Lippincott Williams and Wilkins.
- Kurlan R (2010). Tourette's syndrome. New England Journal of Medicine, 363(24): 2332-2338.
- Bloch MH, et al. (2009). Meta-analysis: Treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders. Journal of American Academy of Child and Adolescent Psychiatry, 48(9): 884-893.
ByHealthwise Staff
Primary Medical Reviewer John Pope, MD - Pediatrics
Kathleen Romito, MD - Family Medicine
Specialist Medical Reviewer Louis Pellegrino, MD - Developmental Pediatrics
Current as ofMay 3, 2017
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Using your 23andMe data: exploring with MDS
Note: please read the the earlier post on this topic if you haven't.
The above image is from 23andMe. It's from a feature which seems to have been marginalized a bit with their ancestry composition. Basically it is projecting 23andMe customers on a visualization of genetic variation from the HGDP data set. This is actually a rather informative sort of representation of variation. But there has always been an issue with the 23andMe representation: you are projected onto their invariant data set. In other words, you can't mix & match the populations so as to explore different relationships. The nature of the algorithm and representation produces strange results, so varying the population sets is often useful in smoking out the true shape of things.
With the MDS feature I wrote about yesterday you can now compute positions with different weights of populations and mixes. This post will focus on how to manipulate the overall data set. You should have PHYLO from the the earlier post. Open up the .fam file. It should look like this:
Malayan A382 0 0 1 -9
Paniya D36 0 0 1 -9
BiakaPygmies HGDP00479 0 0 1 -9
BiakaPygmies HGDP00985 0 0 1 -9
BiakaPygmies HGDP01094 0 0 1 -9
MbutiPygmies HGDP00982 0 0 1 -9
Mandenkas HGDP00911 0 0 1 -9
Mandenkas HGDP01202 0 0 1 -9
Yorubas HGDP00927 0 0 1 -9
BiakaPygmies HGDP00461 0 0 1 -9
BiakaPygmies HGDP00986 0 0 1 -9
MbutiPygmies HGDP00449 0 0 1 -9
Mandenkas HGDP00912 0 0 1 -9
Mandenkas HGDP01283 0 0 1 -9
Yorubas HGDP00928 0 0 2 -9
And so forth. PHYLO has 1,500+ individuals. This is a bit much, which is why the – -genome command took so long. To ask particular questions it is often useful to prune the population down. I have a friend who is 1/4 Filipino who is curious as to whether his ancestry was more Chinese or native Filipino. How to answer this?
– You want a range of East Asian populations, north to south.
– You want a good out group. I'll use the Utah whites.
All you need to do is go through the .fam file and keep only those lines you want, and put them into a new file, keep.txt. Then you run this command:
plink – -noweb – -bfile PHYLO – -keep keep.txt – -make-bed – -out PHYLONARROW
So I've now made a new pedigree data set which is a subset of the original. Now I merged my friend and my daughter's genotype into this data set. What about if I wanted to remove some individuals, for examples, the ones in keep.txt? You do it like so:
plink – -noweb – -bfile PHYLO – -remove keep.txt – -make-bed – -out PHYLOAFEWGONE
With – -keep and – -remove, and making files drawn from the .fam file(s), you can customize your own data set for your own purposes. Again you want to produce an MDS, so run:
– -plink – -noweb – -bfile PHYLONARROW – -genome
-plink – -noweb – -bfile PHYLONARROW – -read-genome plink.genome – -mds-plot 6
This time – -genome will run very fast, because there are far fewer individuals. Here is my plot of the result of the outcome (my friend is "RF," my daughter is "RD"):
Note that RF is aligned straight toward the "Dai" population, an ethnic group from South China, but not Han (they are related to the Thai). It seems plausible that my friend is of mixed Chinese and Filipino background. My daughter's minimal East Asian ancestry is indeed Southeast Asian, and this is clear from this plot, as she is shifted further toward the Cambodians (this may be due to South Asian affinities as well).
The point is not to rely on one plot, but to generate many so as to explore the possibilities, and develop and intuition.


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Written by David Postlethwaite
There are several ways that you can audit who has logged in to your SQL Server. The easiest way is to turn on logon Auditing under server properties. Here you can audit failed logins, successful logins, or both.
This will put the audit records into the Windows event log. The failed logins is pretty useful because there shouldn't be many of them. But the successful logins turns out not to be so helpful because it records every single login which includes the service account. It turns out this logs into the server every few seconds so you end up with so much data in the event log that it's impossible to find anything else, especially the rogue user.
The Enterprise version has a built in auditing option which writes to a user defined event log but again this still suffers the same problem in that it audits every login.
What would be better is a way of selectively auditing only those logins we want to see (or not recording those we aren't interested in).
One way this can be achieve is by using a login trigger to write the login information to a table. We can easily collect the login information we want:
App_Name() will tell us the calling application
HOST_NAME() will tell us the calling computer
eventdata() can return the login name
The trigger can capture the login data and run a query to filter out the logins we don't want to record and then write the data to a table.
In this case I chose to filter on the application name rather than a login name. My thinking here was that a user who can use the application might be tempted to try and use Excel or Access to view the raw data. This worked well but I found the table was filling up with records of me using SSMS. I didn't want to audit the DBA team doing their day to day job but I definitely wanted to audit anyone else using SSMS. So I added a second filter to look for a combination of User Name, Application Name and connecting Host Name.
1st create a table to hold the login information
CREATE TABLE [dbo].[Succ_Logins](
[Succ_ServerName] [varchar](100) NULL,
[Succ_EventTime] [datetime] NULL,
[Succ_EventType] [varchar](100) NULL,
[Succ_LoginName] [varchar](100) NULL,
[Succ_IPAddress] [varchar](100) NULL,
[Succ_HostName] [varchar](100) NULL,
[Succ_AppName] [varchar](100) NULL,
[Succ_EventData] [xml] NULL
2nd create a table to hold the logins that we don't want to audit
CREATE TABLE dbo. LoginsNotToAudit(
[App_AppName] [varchar](100) NULL,
[App_HostName] [varchar](100) NULL,
[App_LoginName] [varchar](100) NULL
ALTER TABLE [dbo].[ LoginsNotToAudit] ADD CONSTRAINT [DF_LoginsNotToAudit_App_HostName] DEFAULT ('') FOR [App_HostName]
ALTER TABLE [dbo].[ LoginsNotToAudit] ADD CONSTRAINT [DF_LoginsNotToAudit_App_LoginName] DEFAULT ('') FOR [App_LoginName]
Add some records . Note you can use a % in the value
insert into dbo.LoginsNotToAudit (App_AppName) values ('Microsoft SQL Server')
insert into dbo.LoginsNotToAudit (App_AppName) values ('Report Server%')
insert into dbo.LoginsNotToAudit (App_AppName) values ('SQL Server Data Collector%')
insert into dbo.LoginsNotToAudit (App_AppName) values ('SQLAgent%')
insert into dbo.LoginsNotToAudit (App_AppName) values ('Data Collector%')
insert into dbo.LoginsNotToAudit (App_AppName) values ('DatabaseMail%')
insert into dbo.LoginsNotToAudit (App_AppName) values ('Microsoft SQL Server Management Studio - Transact-SQL IntelliSense')
insert into dbo.LoginsNotToAudit ([App_AppName],App_HostName,App_LoginName) values('.Net SqlClient Data Provider%','Computer1','User1')
And here is the trigger
CREATE TRIGGER AuditSQLLogins
on all server
with execute as 'sa'
for LOGON
DECLARE @event XML
SET @event = eventdata()
IF (select count(App_AppName) from auditDB.dbo.LoginsNotToAudit
where App_Name() LIKE App_AppName AND APP_HostName='' AND App_LoginName=''
App_Name() LIKE App_AppName AND APP_HostName=HOST_NAME()
AND App_LoginName=CAST(@event.query('/EVENT_INSTANCE/LoginName/text()') AS VARCHAR(100))) = 0
INSERT INTO auditDB.dbo.Succ_logins (Succ_EventTime,Succ_EventType,Succ_LoginName,Succ_IPAddress,Succ_AppName,Succ_HostName,Succ_ServerName,Succ_EventData)
VALUES(CAST(CAST(@event.query('/EVENT_INSTANCE/PostTime/text()') AS VARCHAR(64)) AS DATETIME),
CAST(@event.query('/EVENT_INSTANCE/EventType/text()') AS VARCHAR(100)),
CAST(@event.query('/EVENT_INSTANCE/LoginName/text()') AS VARCHAR(100)),
CAST(@event.query('/EVENT_INSTANCE/ClientHost/text()') AS VARCHAR(100)),
-- This will not stop the trigger from returning an error
I've run this on several 2008 servers without any noticeable degradation in performance.
But there is a major drawback of using a Login trigger.
If the code causes an error then the trigger will fail. If it fails then the users can't login. They will receive an error Logon failed for login 'Domain\username' due to trigger execution.
No amount of try- catch, error trapping or transaction rollbacks will help. Any error will cause the trigger to exit as failed I found this out when a new application started using the server but it wasn't added to the LoginsNotToAudit table, the database ran out of room so the insert failed and so the trigger failed and no one could login I now have a daily job that counts the records in the table to check it's not filling up too quickly
If the trigger is failing then the only way to login is to use the Dedicated Administrator Connection or DAC. The Login Trigger doesn't fire when you login using the DAC.
- Only sysadmins can use DAC
- There can be only one DAC connection at a time
- To use DAC with SSMS, prefix the server name with ADMIN: The important point with SSMS is you can only open a query window with DAC you can't use Object Explorer since this uses more than one connection -you will get an error.
- You can also use SQLCMD with the "-A" switch SQLCMD –A –S [SQL Server Name] –U [User Name] –P [Password] –Q [query]
- By default you can't connect remotely using the DAC so make sure you can RDP to the SQL Server
To allows remote connections use sp_configure, but there is are security implications of allowing remote DAC connections
sp_configure 'remote admin connections', 1
reconfigure with override
Once you have your DAC connections you can disable the query using
disable trigger AuditSQlLogins ON ALL SERVER
If you do need to audit logins to SQL this does work very well but does require some administration. Make sure all the DBAs know how to disable the trigger in the event it does fail and keep an eye on the number of records you are collecting. In my experience once you filtered out he DBAs and the application connections there aren't that many records. Which makes looking for the rogue user a bit easier.


text:
The Hottest Girls app hit the Apple App Store Thursday morning -- the first app to feature full frontal nudity. TechCrunch later reported that users were no longer able to access Hottest Girls, and in our very scientific tests, we too were unable to download porn to our iPhone. Sad.
Apple did not immediately respond to a request for comment.
The company has had a rocky history with certain apps and its own approval process. Everything from farts to baby shaking to the pricey but useless "I Am Rich" app have come under fire, and it looks like porn will soon be added to that list.


text:
Monthly payments required. Valid on Amount Financed of $2,500 or more of new 2018 Star Venture & Eluder purchases made between 9/1/19 and 11/30/19 on your Yamaha installment loan account. Rate of 0%, 5.99%, 9.99%, 13.49% or 16.99% will be assigned based on credit approval criteria. Example: A 60-month term on a $24,000 purchase, at a 0% rate requires monthly payments of $400. A 60-month term on a $24,000 purchase, at a 16.99% rate requires monthly payments of $596.33. Program minimum amount financed is $2,500 and minimum 0-10% down payment required. Offer is subject to credit approval by Synchrony Bank. CANNOT BE COMBINED WITH CUSTOMER CASH OFFER.
Customer cash offer good on select models 10/1/2019 through 12/31/2019. See dealer for additional customer cash available on prior year models.
Transcontinental Touring
$2500 Customer Cash
D.J. George - 2011 Novice Rider of The Year!!


text:
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text:
Underground - Snap #428
This week Snap digs deeper with amazing stories of the hidden, the secret... the subterranean. On the next Snap Judgment from NPR and PRX, "Underground."
Lowdown on the High Fade
Glynn finds out just how far he'll go to look good.
Producer: Pat Mesiti-Miller
The Little Girl Who Traveled With America's Most Wanted
What happens when a nine year old is forced to sever ties with everyone she knows and go underground.
Producer Anna Sussman.
(Find out more about the world of Jeff Greenwald here. )
The Long, Strange, 60-Year Trip of Elmer McCurdy
Elmer McCurdy led a life of poverty, illness and crime. But the injustices subjected to his corpse after his death made his afterlife much, much worse.
Learn more about Elmer's story by reading "Elmer McCurdy: The Misadventures in Life and Afterlife of an American Outlaw by Mark Svenvold."
Producer Stephanie Foo
How One Woman's Secret Discovery Under A Parking Lot Changed 500 Years of History
Philippa Langley got a weird feeling when she walked over a parking lot in Leicester one day. A feeling like maybe a dead king was buried underneath it. So she invested all her time and money on a search for King Richard III.
Read Philippa's incredible story in her book: The King's Grave.
Producer Stephanie Foo


text:
jeanniebigbed 4
jeanniebigbed 4
from 300.00
Fine Art Giclée Print
Limited Edition: 250
[click on image to enlarge]
Print Size:
Add To Cart
LAMENSCH DOUGLAS FINE ART (LDFA) PUBLISHING is making available Jamie Adams Artist's Limited Edition Prints. Each limited edition Giclée print is signed by the artist and numbered within the edition of 250.
PAPER - The following works are printed on Fine Art Archival Paper and Pigmented Inks.
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PRINTS NOT LISTED? - For questions regarding prints of other works or sizes not listed, contact the studio at: firstname.lastname@example.com.


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High-End Server Chips Debut at Hot Chips '12
While Intel and AMD account for most of the volume, a fair number of servers (which make up a substantial part of revenue) run other chip architectures. At the annual Hot Chips conference yesterday, representatives from IBM, Oracle, and Fujitsu discussed the architectures their organizations will use in creating high-end microprocessors, typically used in applications ranging from mainframes to high-performance computing. All of these are large processors and tend to use the most advanced techniques. In addition, Applied Micro showed off what is likely to be the first 64-bit ARM server chip to ship, while Intel detailed its existing Xeon E5 processor. (I wrote about other AMD and Intel's offerings yesterday.)
IBM's Scott Taylor discussed the next Power 7+ microprocessor, used in the company's Power systems, typically used for ERP, OLTP, and Java. This chip features eight processor cores, with four-way symmetric multithreading, allowing for a total of 32 threads per chip. Each core has 256KB of level 2 cache, and, in a concept introduced with the earlier Power 7, the chip has 80MB of embedded DRAM as a shared level 3 cache (in contrast with the SRAM usually used as cache in most chips). It is designed to support systems up to 32 sockets. As you might expect, this is a big chip, measuring 567 square millimeters manufactured on a 32nm SOI process.
What's new in this version? It has 2.5 times the amount of level 3 memory, an improved core that allows for up to a 25 percent improvement in frequency, a doubling of single precision floating-point performance, dedicated accelerators to speed up tasks like SSL and file encryption, random number generation, and more power gating for better power management. The Power 7+ is meant to be socket-compatible with the older Power 7, including support for a dual-chip module, which would give a system twice the number of cores and five times the amount of L3 cache as with the earlier chip.
For its mainframe business, IBM showed off its zNext, its third-generation high frequency microprocessor capable of running at up to 5.5GHz, the highest rated speed I've seen for a mass produced server chip. This is the heart of the new zEnterprise EC12 mainframe.
Compared with the previous version (the z196), the zNext will have six cores instead of four and runs at 5.5GHz rather than 5GHz. IBM's Chung-Lung (Kevin) Shum touted advances in the cores themselves, including improved out-of-order operations and a streamlined pipeline, as well as improvements in the cache subsystem. The chip has 48MB of embedded DRAM as a shared level 3 cache, twice as much as the previous version. IBM says this will be the first general purpose microprocessor to support hardware transactions memory and self-directed runtime profiling to help the system tune itself.
Overall, the processor uses 2.75 billion transistors on a 597 square millimeter chip produced on a 32nm SOI process.
In the SPARC family, both Fujitsu and Oracle showed new 16-core architectures, as each takes the architecture originally designed by Sun in different directions.
Fujitsu's Takumi Maruyama showed off the SPARC64 X, a new generation process aimed at UNIX servers. The idea here is to combine features from the company's previous generations aimed at UNIX servers (SPARC64 VII+, which offered a high frequency, up to 3GHz) and high performance computing (SPARC64 VIIfx, which had a higher memory bandwidth). In addition, it adds new hardware acceleration for decimal operations, encryption, and database acceleration.
The Sparc64 X has 16 cores with two threads each, 24MB of level 2 cache, and runs at up to 3GHz, with over 100GB/s peak memory bandwidth. Overall, it uses 2.95 billion transistors on a 540 square millimeter die on a 28nm CMOS process. Fujitsu claims top performance at 382 Gigaflops (billions of floating point instructions per second), and says it has shown seven times the throughput of the Sparc64 VII+.
Oracle's Sebastian Turullols and Ram Sivaramakrishnan showed off the SPARC T5, a 16-core processor optimized for Oracle workloads and engineered systems produced at 28nm. The basic processor includes 16 of the SPARC S3 cores running at 3.6GHz, along with 8MB of shared L3 cache. The cores seem to be shrinks from the 40nm T4, with dynamic threading allowing up to eight "strands" per core, with advanced on-chip encryption acceleration designed to work with the Solaris ZFS file system for faster system encryption. Each core has a 128KB level 2 cache and a crossbar interconnect links the 16 cores to an 8MB 16-way level 3 cache.
This mostly seems to be a shrink of the SPARC T4, but what's different is that the chips are specifically designed to allow for eight-way "glueless scalability." (In other words, designers can connect up to eight chips without any other logic chips controlling them, compared with four chips in the previous generation.) This uses a directory to track all of the level 3 caches in the system and maintain coherency among them, with a high-speed internode coherency fabric. Oracle didn't disclose the chip size.
Perhaps the most interesting architecture, and certainly the newest, comes from Applied Micro, which showed off its upcoming 64-bit ARM-based CPU known as X-Gene, available later this year. Gaurav Singh and Greg Favor talked about how many workloads are moving from being CPU intensive to being data movement intensive. Applied Micro has an ARM architectural license, so it has designed its own cores around the ARMv8 instruction set. The company says it will result in a high-performance, but low-power microarchitecture aimed at balancing performance, power, and size.
This is built on compute modules which have two 64-bit cores (a four-way out-of-order superscalar microarchitecture) and a shared L2 cache. Each of these cores has its own 128-bit SIMD floating point unit. Multiple modules (it showed three in the diagram) would be connected to a shared L3 cache, and the system is designed to have multiple chips all connected on a interconnect bus with DRAM and 10Gbit networking. Applied Micro calls it the "world's first true low power server on chip." A number of other companies have started showing ARM-based server chips including Marvell and Calxeda (with indications that Cavium, Nvidia, and Samsung are working on it), but it looks like Applied Micro will be the first to bring a 64-bit ARM server chip to market.
Also in this session, Intel talked about its more mainstream Xeon E5 processor, known as Sandy Bridge-EP. This is an eight core, 16 thread chip produced on a 32nm process, using a high bandwidth ring interconnect that is already shipping as part of the company's Romley platform.
Intel's Jeff Gilbert and Mark Rowland described how the changes from the Nehalem/Westmere architecture to the Sandy Bridge cores, plus the addition of the on-die ring interconnect, additional memory channels and faster inter-socket communications (QPI) helped improve performance, while changes such as running average power limiting helped reduce power consumption.
This has quickly become the mainstream server processor and on a volume basis, I wouldn't be surprised if it outsold all the others combined. Still, it's interesting to see how other vendors continue to find niches and applications for a variety of other designs.


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Exclusively commissioned by TripAdvisor
About Kirsty S
Lives in London, United Kingdom
Since Feb 2015
I have travelled extensively through Southeast Asia. I know Thailand and Malaysia particularly well, but also love Vietnam, Cambodia and Singapore. I travel to this part of the world whenever I can, sometimes on a short trip while on route to Australia, and sometimes for extended periods of time so that I can really get beneath the skin of a particular area – whether I've been to that spot before or not. I've spent a lot of time in Bangkok – it's a fascinating melting pot of a city where there's always something new to explore. I also love Hanoi and have explored it both independently and as part of an organised tour. More than anything, I love discovering something new while travelling and sharing it with those who have the same passion for travel as I do. I'm a bit of a foodie and never get bored of the beach.
Tired of the same old tourist trails in the capital cities you've visited? Maybe it's a case of 'been there, done that' when it comes to Bangkok? Perhaps you simply like your travel experiences to be as unusual and unique as you are. Either way, get ready for Bangkok off the beaten path…
10 Places
4 City Tips
10 Places
Sacred & Religious Sites
Points of Interest & Landmarks
Speciality Museums
Speciality Museums
Flea & Street Markets
Flea & Street Markets
Architectural Buildings, Speciality Museums
Flea & Street Markets,
Flea & Street Markets
There's a phallus shrine at the back of the Swissotel Nai Lert Hotel in central Bangkok. Yes, it's exactly as it sounds. From small wooden sculptures to huge stone monuments, this is an unusual attraction even for Bangkok's standards. The shrine pays homage to Chao Mae Tubtim, a female fertility spirit. It sees local women visiting to pay their respects when trying to conceive but is also open to any visitors whose curiosity gets the better of them.
There's a Buddhist temple in Bangkok that has an effigy of David Beckham within it. Wat Pariwas sits right on the Chao Praya River within Chinatown. It's important to note that this is not a temple that's entirely dedicated to the man himself – but he's certainly in there, carved inconspicuously into the alter. In fact, half the fun is finding him amid the garudas (guardian demons).
Not for the faint of heart, the Siriraj Medical Museum is not only unusual, it's downright morbid. The museum is located inside the Siriraj Hospital on the west banks of the Chao Phraya River, and displays such artefacts as dissected and deformed body parts and preserved human skeletons. It's niche to say the least. Don't say I didn't warn you!
Located on Maha Chai Road (past Chinatown and just before Wat Suthat) the Corrections Museum is a highly unusual Bangkok attraction. It's situated in what's left of an old maximum security prison that was built in 1890. The museum serves to educate the public of the horrifying way the prisoners were treated there – and it certainly does just that.
You'll have to duck out of the city for this one, but it'll be worth it to see one of the most unusual markets in the country – if not the world. Situated in Samut Songkhram, just under 40 miles west of Bangkok, the unsuspecting Maeklong Railway Market sees trains passing directly through it up to eight times a day. Situated literally right on the railway line, the market vendors have to scoop up their wares to allow the trains to pass through, and then everything goes back to exactly how it was! Quite a bizarre occurrence that has to be seen to be believed.
A visit to the Khlong Toey Market is a real local experience – and definitely one for the foodies. It's a sprawling and chaotic fresh food market tucked away deep within the concrete city blocks near the centre of town. The market sells a lot of raw meat and seafood, along with a variety of freshly cooked dishes, and is a world away from the tourist-centric markets you may have visited in the past.
Already famous for reviving silk weaving in the country, it was American Jim Thompson's sudden and mysterious disappearance in 1967 while walking in the Cameron Highlands that turned him into a household name in Thailand. His house is made up of six teak buildings that are now home to artifacts from his private silk collection, as well as a museum. Sure, there's likely to be other tourists on your visit but its off-the-tourist-track location tends to keep numbers down. Plus it makes a change from visiting temples and palaces for the afternoon.
The Train Night Market is no more. Well it is, but it has moved and is now referred to as Rod Fai. Most tourists head to Chatuchak Market when they want to experience one of the capital's large markets. But for a more authentic feel of an open-air night bazaar selling everything imaginable, savvy visitors to Bangkok head here. It's unique in that it sells a vast array of vintage collectables and retro memorabilia alongside the usual fare, and you won't find a great deal of tourists here either.
It may be smaller, but Khlong Lat Mayom is much more of a local affair than the more popular Damnoen Saduak and Amphawa Floating Markets near Bangkok. A relaxed local market in a lush rural setting, here you can eat at a 'boat restaurant', hire a vessel to drift down the canal in, or browse the dry market for handicrafts and souvenirs to take home.


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Pivot teams with Stanley Tucci for new TV series
BEVERLY HILLS, Calif. (AP) — Pivot is getting into scripted drama with a new TV series starring former Oscar nominee Stanley Tucci (TOO'-chee).
The nearly year-old network focuses on viewers 18 to 34. It plans to launch "Fortitude" in January with 12 one-hour episodes.
Tucci plays a detective who arrives in a small Arctic town called Fortitude to search for a killer alongside the local sheriff played by Richard Dormer, who's known for "Game of Thrones." The series was filmed in Iceland and Britain.
The show marks Tucci's first extended television role since he did a 10-episode arc on "ER" six years ago. He was nominated for a supporting actor Oscar in 2009 for "The Lovely Bones."
The network announced the show Friday at the summer TV critics' meeting.
Pivot also says it's bringing back comedy "Please Like Me" for a third season.
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The International Journal of Psychoanalysis
The International Journal of Psychoanalysis
Vol 98(6 Issues in 2017 ) Print ISSN: 0020-7578 Online ISSN: 1745-8315
Download Product Flyer
The International Journal of Psychoanalysis is a fully peer reviewed journal published six times a year (February, April, June, August, October and December) since its merger with The International Review of Psycho-Analysis in 1994. It is the only psychoanalytic journal regularly publishing extensive contributions by authors throughout the world - facilitated by a system of international editorial boards and the policy of allowing submission and review in all main European languages, followed by translation of accepted papers at the Journal's expense.
We publish contributions on Psychoanalytic Theory & Technique, The History of Psychoanalysis, Clinical Contributions, Education & Professional Issues, Psychoanalytic Psychotherapy, Interdisciplinary Studies, and Film Essays. The Journal also publishes the main papers and panel reports from the International Psychoanalytical Association's Congresses, book reviews, obituaries, and correspondence.


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ColorSnapper: A Slick, Simple Color Picker for the Mac• • ☕ 1 min read
If you're a web or graphic designer, you know how useful a desktop color picking application can be. There's nothing more ridiculous than loading up Photoshop just to identify a particular color value. Although OS X does have a native app for this in the form of DigitalColor Meter (in Applications/Utilities), it's a fairly simple app.
ColorSnapper bills itself as the missing color picker for Mac OS X. Although this is a little bit of an overstatement (OS X does have one, after all), this doesn't change the fact that it's a pretty neat app.
I know a color picker is something that I use on a regular basis, so let's see whether ColorSnapper really can offer an advantage over DigitalColor Meter…
Read the full article on Mac.Appstorm


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Funds That Support the Master's of Business Administration
Above: Two UIS MBA students.
Make a Difference for Master's of Business Administration Students
Business Administration Program Fund
- This fund provides money for special opportunities or extraordinary needs.
- Faculty and students can travel to a conference to present their research.
- Faculty can take part in a special opportunity to update their skills. Professors need to be aware of the latest developments in their field, so that they can pass this knowledge on to their students.
- The department can purchase special equipment, test materials, resources, or training modules to help our students attain success and achieve their goals.
These activities and others like them enrich our students immeasurably, enhancing the education they receive at UIS—but we could not do any of them without the discretionary money given to this fund.
Eugene R. and Elaine A. Wilkinson Scholarship Fund
Fifty percent of the Wilkinson Scholarship Fund award will be used to provide scholarships to undergraduate students enrolled in the Department of Business Administration while another fifty percent will be used to provide scholarships to undergraduate students enrolled in the Department of Management Information Systems.
Other Options
Not interested in any of the funds above? Then you can create your own named scholarship fund—either a current use scholarship or an endowed scholarship—that targets the students working on their Master's of Business Administration. As the principle donor of this new scholarship, you would get to name the fund and establish the selection criteria.
We welcome your inquiries. Please feel free to contact us.


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|Grave Danger, Part 1
|Carol Mendelsohn,
Naren Shankar,
Quentin Tarantino,
Anthony E. Zuiker
|Quentin Tarantino
|Original Airdate
|May 19, 2005
|Previous Episode: Iced
|Next Episode: Grave Danger, Part 2
Grave Danger, Part 1 is the twenty-fourth episode in season five of CSI: Crime Scene Investigation.
The separated graveyard-shift team join together as one of their own is kidnapped from a crime scene and held for a million dollars ransom by a mysterious and vengeful assailant. However, it soon appears that the kidnapping may be about more than the ransom
Nick is driving to the latest crime scene, listening to Bob Neuwirth's Lucky Too. Once he arrives, an officer shows him the "body," which is a set of intestines. After the officer wanders off to his cruiser to throw up, Nick starts taking pictures of the evidence, unaware that someone is watching him from behind a dumpster. Once Nick finds a Styrofoam cup in a yellow-sealed evidence bag, the unknown figure snatches him and puts a cloth over his mouth. 25 minutes later, police cars and CSIs swarm the scene. Conrad Ecklie tells Grissom and Catherine that "the crime lab has only one case tonight." Catherine finds Nick's vest with some white fibers on it. She then finds the bagged cup and realizes that he didn't bag it.
Several hours before, Sara and Grissom are reviewing a past homicide case, Greg and Hodges are playing a board game, and Nick and Warrick are deciding which case they will take: an assault at a strip club or a "trash run." Warrick takes the strip club sex
Meanwhile, Nick wakes up in the back of a car with his hands tied behind him. The car stops and someone gets out (we don't see that happen.) A gloved hand comes over Nick's mouth, and knocks him out.
At the crime scene, Warrick discovers a void in the rain and takes measurements. The getaway car is determined to be a White Ford Expedition.
Somewhere unknown, the kidnapper (not yet identified) places an unconscious Nick in a Plexiglas coffin, throws in a lit glow stick, his loaded pistol, several unlit glow sticks, and a Dictaphone. He shuts the lid and shovels dirt on top of it.
In the conference room, everyone is discussing the evidence they found. There were no prints or DNA on the coffee cup or bag. Outside, Hodges is fighting with the delivery man, and manages to grab the package labeled "RE: STOKES." Grissom cuts open the package and finds a flash drive and audio tape.
Nick wakes up and hits his head on the top of the coffin. After observing his new surroundings, he finds the Dictaphone. A taunting voice begins talking:
"Hi, CSI guy. You wondering why you're here? Because you follow the evidence. Because that's what CSIs do. So breathe quick, breathe slow, put your gun in your mouth and pull the trigger. Any way you like, you're going to die here."
Nick starts panicking and begins screaming for help, but unfortunately no one can hear him.
At the lab, Grissom plays the audio tape, which just taunted them by playing "Outside Chance" by The Turtles. The flash drive contains a message:
"One million dollars in 12 hours or the CSI dies. Drop-off instructions to follow. And now for your viewing pleasure...you can only WATCH."
The team watches in horror as Nick continues to panic and try to escape his prison.
Brass goes to the house where the delivery boy was paid to deliver the letter, but it turns out to be a dead end. The only person in the house is an extremely overweight drunk, sleeping on the couch.
Nick's parents arrive at the lab and Grissom shows them the video.
Catherine, desperate, asks her dad, Sam Braun, for a million dollars, since the city will not finance a ransom. After some hesitation, he does turn over the money.
She gives the money to Grissom, who is not happy that he received a criminal's money, but accepts it. A message pops up on the computer a few minutes later:
"4672 Carney Lane, Boulder Highway" — and a deadline: "Be there in 20 minutes, or don't bother coming."
Grissom heads alone to the address, finds a dog's corpse, and a vehicle that matches the description of the getaway car. He gives the money to the kidnapper, who is hesitant. He doesn't know if the money is real or not. The kidnapper begins taunting Grissom, saying that there is nothing that he can do to save his friend.
The perpetrator reveals a Semtex vest and blows himself up. Grissom is seen lying on the ground, covered in blood and money flying everywhere.
Main Cast
- William Petersen as Gil Grissom
- Marg Helgenberger as Catherine Willows
- Gary Dourdan as Warrick Brown
- George Eads as Nick Stokes
- Jorja Fox as Sara Sidle
- Eric Szmanda as Greg Sanders
- Robert David Hall as Dr. Al Robbins
- Paul Guilfoyle as Jim Brass
Guest Cast
- Scott Wilson as Sam Braun
- Andrew Prine as Rodger Stokes
- Wallace Langham as David Hodges
- Marc Vann as Conrad Ecklie
- Archie Kao as Archie Johnson
- David Berman as David Phillips
- Tony Curtis as Himself
- Frank Gorshin as Himself
- John Saxon as Walter Gordon
- Lois Chiles as Jillian Stokes
See Also
- List of CSI: Crime Scene Investigation episodes
- CSI:Crime Scene Investigation Season 5
- Category:Images from Grave Danger, Part 1
< Iced
|CSI:Las Vegas Season 5
|Viva Las Vegas • Down the Drain • Harvest • Crow's Feet • Swap Meet • What's Eating Gilbert Grissom? • Formalities • Ch-Ch-Changes • Mea Culpa • No Humans Involved • Who Shot Sherlock? • Snakes • Nesting Dolls • Unbearable • King Baby • Big Middle • Compulsion • Spark of Life • 4 x 4 • Hollywood Brass • Committed • Weeping Willows • Iced • Grave Danger, Part 1 • Grave Danger, Part 2


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BY Ewy Mathé
As early as elementary school, I was fascinated by science and medicine and was convinced I would become a brain surgeon. By the time I went to college, this changed toward forensics, and by the end of college I was thoroughly confused and realized that I hadn't quite found my greatest interest yet.
Having been fortunate to find a job in a yeast genetics laboratory, I sequenced and ran Westerns for a year and realized that bench work was not my forté. Importantly, though, bench work provided a lot of downtime that I, like most everyone else, used to browse the Internet.
During that time, as I was waiting for my timer to go off, I found my new calling: bioinformatics – specifically, protein-structure modeling. I started calling around to different academic institutions that offered bioinformatics degrees and decided to embark on a Ph.D. at George Mason University. The learning curve was steep (I had no computer-science classes under my belt when I applied), but the field switch was exciting and proved to be the best decision.
Why bioinformatics?
One of the most exciting aspects of bioinformatics for me is its collaborative nature. Indeed, the field would not exist without large masses of raw data being generated that are of little worth without bioinformatics interpretation.
This dependency requires building a bridge between related yet diverse fields, both linguistically and knowledgewise, and thus provides opportunities to step out of your scope to better understand the challenges at hand. I find this aspect very exciting, as it allows me continuously to learn new biological aspects that I might not necessarily explore on my own.
Furthermore, bioinformatics can be thought of in the context of team-science approaches that are becoming more prevalent as scientific projects grow in size and complexity. Indeed, the high level of expertise required and the increasing demands from publishers make it difficult thoroughly to address all aspects of a given project.
Nowadays, bioinformatics is most always a component of larger scale projects that require a team of experts who may or may not know each other. This team-science approach requires strong communication and the ability to coordinate efforts and keep the project moving along. Keeping everyone in line with the vision of the project and making expectations clear are critical for building a successful team.
Another stimulating aspect of bioinformatics for me is that it is not routine. The majority of the projects I undertake require novel applications and interpretations. A typical project requires unique ways of looking at the data and thus also requires a strong understanding of the biological question at hand. Furthermore, the field is very fast paced. While this attribute may be daunting, it is also very exciting, as bioinformatics is always at the forefront of new technologies and applications.
A whole new world
Just as the bioinformatics field is very broad, the topics that I touched on in my training (and I am still training!) are also broad. During my Ph.D., I took advantage of lab rotations to touch on very different aspects, including image analysis, Monte Carlo simulations, genetic algorithms and computational geometry/protein-structure modeling.
While my thesis was centered on computational geometry and sequence alignments, I again switched gears in my postdoc and delved into genomics and metabolomics, all with a molecular epidemiology flavor. This switch has opened a whole new world for me, and, importantly, I had chosen to be in a wet lab environment as opposed to a purely computational laboratory.
The reason for this choice was to make sure that I stayed up to date with biology and learned how to communicate well with different participants in a given project. While you can stay up to date via the literature, I found it extremely valuable to be able to interact directly with bench scientists and have learned a lot from this direct interaction.
Life can shape your career path
On a more personal note, my career path also has been molded by the fact that cancer has plagued my family, as it has a large number of families. Right after applying to Ph.D. programs, my brother was diagnosed with stage 3 melanoma.
It was at that moment that I decided I wanted to invest my efforts in cancer research. I found a way to fit cancer research into my Ph.D. thesis by studying the p53 protein and mutations, which are very common in various cancer types. Since then, I have focused on finding diagnostic and prognostic markers in early stages of esophageal and lung cancers. This additional personal dimension to my research makes my work more personally valuable and drives me to do the best I can do.
Charting your path
As you are reading this, you may be asking yourself, "What is the best trajectory for a successful career?" My answer to this is none. I do not think there is a best trajectory. This last statement should be more reassuring than alarming.
Indeed, I believe that everyone has to carve his or her own trajectory, as there is most likely a variety of definitions of a successful career. Do you define success as having achieved independence? Or perhaps by how much recognition or awards you are getting? Or perhaps by salary? By having achieved a good balance between family and work? By doing "good science"?
I find it very important to do a bit of soul searching to determine what makes you happy and how you envision your success, with the understanding that another person's idea of success may not necessarily fit yours. Furthermore, recognize that your vision of success is not static and that it will probably evolve with time.
In this sense, it is useful to self-evaluate regularly and make changes accordingly. After all, your happiness in your work is directly correlated with drive and desire to accomplish tasks well. In other words, ensuring satisfaction with your work makes you most productive.
Finding and using mentors
It is very useful to discuss professional development with mentors. Often, a laboratory chief or primary investigator is a default mentor. However, mentors can also be peers and collaborators from within or outside your institute.
Seeking outside mentors can be beneficial, because there is less fear of crossing a line that may affect daily work.
In addition, being a mentor can be quite fruitful in that it may force self reflection, deepen your knowledge, help build leadership skills, establish valuable professional relationships and provide a sense of gratification from contributing to someone's advancement.
Taking this even a step further, it is essential to network. Participating in committees, attending and presenting at conferences, and forging collaborations are all avenues for networking. The ability clearly to delineate your work and interests is very important, and the ability to break past shyness or reservations and ask questions about others' work and interests is very rewarding.
In my experience, many scientists love to talk about their work and interests and are flattered by inquiries. Opening up communications can be a great self-confidence builder and can establish important relationships.
Overall, I apply all the various aspects I have mentioned here in my career as I advance on my journey toward my self-defined success. I hope at this point that one main message is becoming apparent: Following a career path is a personal journey that may be redefined as you move forward. Also, acquiring expertise and knowledge should not be the only aspirations, for they are baselines.
With lots of Ph.D.s and brilliant people out there, we are all competing against the cream of the crop. With this in mind, it is critical to evaluate yourself frequently, redefine your vision, network and communicate clearly. These are very high expectations, and some aspects come more naturally to some than others. However, the same drive that kept us working long hours to finish our theses should be kept alive so that we continuously challenge ourselves to keep improving and learning.
After all, continual learning may be the most exciting aspect of working at the doctoral level!
More from the current issue


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Successful Implementation of SPECTAcolor, the First Pan-European and EORTC Screening Platform, Proves that a Logistically Complex Infrastructure to Run Next Generation Trials in a Multinational Setting is Feasible
Over 500 patients in and availability of high quality biological materials
- Date: 22 Jan 2015
- Topic: Personalised medicine / Translational research / Gastrointestinal cancers
Screening Patients for Efficient Clinical Trial Access in advanced colorectal cancer's (SPECTAcolor) successful start has demonstrated its viability to facilitate next generation cancer clinical trials. It has been successfully implemented across 19 clinical centres located in nine European countries and has recruited over 500 patients since its launch in September 2013. The observed frequency of mutations is similar to that observed in previous colorectal cancer clinical trials.
In addition, pathological review and core analyses of tumour blocks shipped to the central biobank at Dresden University Hospital for central quality, deemed over 98% of the samples were adequate. Tumour samples are also analysed by Next Generation Sequencing for 360 key cancer genes in cooperation with the Sanger Institute (Cambridge, UK). After informed written consent, patients are screened for molecular alterations. Molecularly annotated patients can be offered so called "downstream" clinical trials.
The results were presented by SPECTAcolor's coordinator Dr. Gunnar Folprecht of the Dresden University Hospital at the 2015 Gastrointestinal Cancers Symposium held 15-17 January 2015 in San Francisco. This successful implementation is evidence that a logistically complex infrastructure to run next generation trials in a multinational setting is feasible.
Improving access to molecularly defined clinical trials for patients with colorectal cancer
Treatments for patients with cancer are becoming increasingly tailored to the molecular characteristics of the particular patient and disease. Consequently, molecularly characterising a patient's tumour is now a prerequisite for them to access the appropriate clinical trial for their particular cancer type. Assessing their tumours, however, is more easily said than done, because the required testing is beyond the scope of most hospitals. Molecular diagnostics can identify subgroups of colorectal and other cancers that are relevant for the mode of action of new anti-cancer agents. The efficient, GCP-conform and quality assured molecular screening to identify potential study patients is one of the major challenges for targeted drug development.
The European Organisation for Research and Treatment of Cancer (EORTC) built a collaborative molecular screening platform, SPECTAcolor, which provides the necessary infrastructure to screen adult patients with advanced-stage colorectal cancer for mutations in colorectal cancer biomarkers. As of 12 September 2014, 406 patients were enrolled – exceeding the expected accrual target of 300 patients in the first year. Of these 406 patients, 293 patients had their tumour block shipped to the central biobank.
A preliminary analysis of biological materials for five baseline cancer biomarkers showed:
- KRAS was wild type for exon 2, 3 and 4 in 151 of 284 patients (53%) and mutated in 133 patients (47%); 114 patients in exon 2 (40%), 8 patients in exon 3, and 11 patients in exon 4.
- NRAS was tested in KRAS wild type patients only and mutations were found in 14 patients (4,9%); 6 patients in exon 2 and 8 patients in exon 3.
- BRAF mutations, all in exon 15, were found in 18 patients (7%).
- PI3K mutations occurred in 41 patients (15%), 13 in exon 20 and 28 in exon 9.
- Immunohistochemistry staining was showing deficient mismatch repair in 16 patients.
SPECTAcolor provides an excellent opportunity for molecular-oriented clinical trials in Europe based on innovative and high-quality partnership models with the pharmaceutical industry. It is supported by a unique partnership between the EORTC Charitable Trust and the Corporate Social Responsibility Program of Alliance Boots.