text:
April 19, 2010
To help doctors give their patients the best possible care, the American Society of Clinical Oncology (ASCO) and the College of American Pathologists (CAP) developed evidence-based recommendations to improve the accuracy of testing for estrogen and progesterone receptors for breast cancer. This guide for patients is based on ASCO's and CAP's recommendations.
Key Points:
- Estrogen and progesterone receptors are found in breast cancer cells that depend on estrogen and related hormones to grow.
- All patients with invasive breast cancer or a breast cancer recurrence should have their tumors tested for estrogen and progesterone receptors.
- This testing should be performed by an accredited laboratory that follows specific testing procedures and handles the samples in a consistent way.
About estrogen and progesterone receptors
Estrogen receptors (ER) and progesterone receptors (PR; also called PgR) may be found in breast cancer cells. Cancer cells with these receptors depend on estrogen and related hormones, such as progesterone, to grow. Estrogen and progesterone influence many hormonal functions in women, such as breast development.
If breast cancer cells have estrogen receptors, the cancer is called ER-positive breast cancer. If breast cancer cells have progesterone receptors, the cancer is called PR-positive breast cancer. If the cells do not have either of these two receptors, the cancer is called ER/PR-negative. About two-thirds of breast cancers are ER and/or PR positive.
About hormone therapy
Learning whether a tumor has estrogen and/or progesterone receptors helps doctors determine a patient's risk of recurrence (return of the cancer after treatment) and whether the cancer can be treated with hormone therapy. Hormone therapy blocks the tumor from using estrogen and/or progesterone for cancers that are ER and/or PR positive, slowing or stopping tumor growth. Two types of drugs may be used; one type called tamoxifen (Nolvadex) can be used for women of all ages, while other types of drugs called aromatase inhibitors (AIs) stop tissues and organs other than the ovaries from producing estrogen. AIs must never be used alone for women who have not gone through menopause.
For women who have not gone through menopause, hormone therapy for ER and/or PR positive tumors may include stopping the production of estrogen and progesterone in the ovaries with surgery or injections.
Testing estrogen and progesterone receptors
Testing the tumor for both estrogen and progesterone receptors is a standard part of a breast cancer diagnosis. Because the results are used to guide treatment, it's important that the results be accurate. The most common method currently used to test a tumor for estrogen and progesterone receptors is called immunohistochemistry or IHC. IHC testing can detect estrogen and progesterone receptors in cancer cells from a sample of tissue. This tissue may come from a biopsy (removal of a small amount of tissue for examination under a microscope), or from the surgery to remove all of the tumor and some or all of the breast.
To improve the accuracy of ER and PR testing, ASCO and the CAP recommend the following:
- The ER and PR status should be tested on the primary tumor and/or areas of spread (called metastases) for each patient newly diagnosed with invasive breast cancer or a breast cancer recurrence.
- A tumor is ER and/or PR positive if at least 1% of the cells examined have estrogen and/or progesterone receptors, and for such a tumor, patients should talk with their doctors about considering hormone therapy.
- Testing is best done on larger tissue samples. If the cancer has spread, testing on those areas may be considered as well.
- Laboratories testing for ER and PR should be accredited by the CAP or meet the additional accreditation requirements in the guideline and show agreement with other validated ER and PR tests for both positive and negative results. The laboratory must also be inspected every two years to be sure that the testing methods conform to the guideline requirements.
What This Means for Patients
Because the results of ER and PR testing can make a difference in a patient's treatment and chance of recurrence, it's important that these tests are accurate. This guideline was developed to help both doctors and laboratories know how to improve the accuracy of ER and PR testing for patients with breast cancer. Understanding the ER/PR status of the primary tumor and any recurrent tumors can help doctors make sure that patients receive the appropriate treatment and avoid side effects of a treatment that may not work. Use this guideline to talk with your doctor about the accuracy of your ER and PR test results and what that means for your treatment.
Questions to Ask Your Doctor
To learn more about estrogen and progesterone receptor testing for breast cancer, consider asking your doctor the following questions:
- What are the results of the ER and PR tests on my tumor sample? What do they mean?
- Does this laboratory meet the standard guidelines like those from ASCO and the CAP?
- Is a board-certified pathologist on my treatment team?
- Do you know if this is an experienced lab and if my tissue was quickly given to the pathologist after my biopsy or surgery as recommended by guidelines?
- Can I obtain a copy of my pathology report (laboratory test results)?
- Is my ER and PR status indicated on the pathology report? Was the ASCO-CAP guideline recommendation used to define the status?
- Based on these test results, what treatments do you recommend and why?
- What are the possible side effects of these treatments?
Helpful Links
Read the entire clinical practice guideline published in the Journal of Clinical Oncology at www.asco.org/guidelines/erpr.
Cancer.Net Guide to Breast Cancer
What to Know: ASCO's Guideline on Hormonal Therapy for Hormone Receptor-Positive Breast Cancer
About ASCO's Guidelines
To help doctors give their patients the best possible care, ASCO asks its medical experts to develop evidence-based recommendations for specific areas of cancer care, called clinical practice guidelines. Due to the rapid flow of scientific information in oncology, new evidence may have emerged since the time a guideline or assessment was submitted for publication. As a result, guidelines and guideline summaries, like this one, may not reflect the most recent evidence. Because the treatment options for every patient are different, guidelines are voluntary and are not meant to replace your physician's independent judgment. The decisions you and your doctor make will be based on your individual circumstances. These recommendations may not apply in the context of clinical trials.
The information in this guide is not intended as medical or legal advice, or as a substitute for consultation with a physician or other licensed health care provider. Patients with health care-related questions should call or see their physician or other health care provider promptly and should not disregard professional medical advice, or delay seeking it, because of information encountered in this guide. The mention of any product, service, or treatment in this guide should not be construed as an ASCO endorsement. ASCO is not responsible for any injury or damage to persons or property arising out of or related to any use of this patient guide, or to any errors or omissions.
Good cancer care starts with good cancer information. Well-informed patients are their own best advocates, and invaluable partners for physicians. Cancer.Net brings the expertise and resources of ASCO, the voice of the world's cancer physicians, to people living with cancer and those who care for and care about them. ASCO is composed of more than 28,000 oncologists globally who are the leaders in advancing cancer care. All the information and content on Cancer.Net was developed and approved by the cancer doctors who are members of ASCO, making Cancer.Net the most up-to-date and trusted resource for cancer information on the Internet. Cancer.Net is supported by The ASCO Cancer Foundation, which provides funding for cutting-edge cancer research, professional education, and patient and family support.
Visit Cancer.Net to find guides on more than 120 types of cancer and cancer-related syndromes, clinical trials information, coping resources, information on managing side effects, medical illustrations, cancer information in Spanish, podcasts, the latest cancer news, and much more. For more information about ASCO's patient information resources, call toll free 888-651-3038.
About CAP
CAP is a medical society serving more than 17,000 physician members and the laboratory community throughout the world. It is the world's largest association composed exclusively of board-certified pathologists and is widely considered the leader in laboratory quality assurance. The CAP is an advocate for high-quality and cost-effective medical care. Archives of Pathology & Laboratory Medicine, the leading peer-reviewed medical journal for pathologists worldwide, is published by the College.


text:
Change Comes From You and Me
If you're like me, you are struggling to see how our country and the world will ever dig out of the multiple messes we've made. How will we untangle Wall Street's outrageous financial shenanigans? Or roll back the levels of CO2 we are pumping into our precious Earth's atmosphere? Or get out of our unending wars?
I rise above my despair by returning to my profound belief in the power of people like you and me to make change. I see, for example, the local food revolution taking hold in so many communities. That revolution has huge implications for rejuvenating community life, making us healthier, and weaning us all, just a bit, off the global economy. Which reminds me of where change starts—with us.
That's why in YES! Magazine we give a lot of space to what people are doing in their communities. Our goal is to build the momentum of those actions until the shifts grow from place to place into a whole new way of living.
That goal is based on the strategic premises that motivated the founding of YES! Magazine back in 1996. I found these ideas so powerful that I left my position at the Ford Foundation in New York to join this fledgling organization. Let me share them with you.
The first is that our society is on an unsustainable path. We knew back then what is so clear now—that we are hitting walls environmentally, socially, and economically. We also knew that reforms at the margins will not do the trick. The problems are too big. What we need is deep change.
The second is that deep change will not come from the top. Economic and political leaders can tweak the system but are too embedded in existing institutions to bring about the level of change that is needed. Big shifts must come from people like you and me—ordinary citizens, unencumbered by entrenched interests. We are free to look at problems as they truly are, imagine different ways of doing things, and work together to live them into being.
The third premise is that the needed changes are already happening in communities in this country and around the globe. It is hard to see those actions as a serious force because they are generally ignored in the mainstream press, the dominant political discourse, and nowadays even the blogosphere and social media.
Pioneers of the New Normal:
We're facing a very different world than the one we knew. Here's what people are doing to prepare …
So what is needed is a way to heighten the visibility of those actions, knit them together to show their significance, and invite others to join. That's what YES! was founded to do.
The truly good news is that, over the 15 years since YES! was founded, the number of positive, community-based initiatives has exploded. In fact there are so many stories to report that we now post every day on the YES! website and never run out of material.
The other news that is deeply satisfying is that you, our dear readers, tell us how much encouragement you get from YES!—that it helps you know you are not alone and that your efforts can add up to real change.
So in spite of very real crises on every side, I take heart. Deep change is coming. The work you are doing to build momentum at the grassroots can make all the difference.
P.S. Want to make sure the YES! stories of grassroots change reach millions of people? You can. Go to yesmagazine.org/donate and make a tax-deductible donation. And during this holiday season, give gifts of YES! We are nonprofit, independent, and reader-supported. We depend on you.
- More articles from , the Winter 2011 issue of YES! Magazine.
- :
Today's families: blended, messy, more diverse, and stronger because of it.
Imagine a no-holds-barred "summit" that comes up with ideas to solve both our job and environmental problems. What might it come up with?

subset: commoncrawl


text:
The Global Pneumatic Actuators Market report keenly analyzes significant features in major developing markets. The analysis includes market size, latest trends, drivers, threats, opportunities, as well as key market segments. The study reveals market dynamics in several geographic segments along with Pneumatic Actuators market analysis for the current market environment and future scenario over the forecast period.
Get Free Sample Copy of Report Here : https://www.apexmarketreports.com/Heavy-Industry/global-pneumatic-actuators-market-by-product-type-by-363298#sample
According to world financial development, the Pneumatic Actuators market measure is evaluated from xx.xx of million $ in 2018. The Pneumatic Actuators Market is required to surpass more than US$ xx.xx million by 2025 at a CAGR of xx.xx in the given estimate period frame. To understand key growth segments in terms of growth and adoption for Pneumatic Actuators industry globally, we have developed the cellulose film packaging market 'Attractiveness Index.'
The Prominent Players in the Global Pneumatic Actuators Market Are As Follows
Air Torque
CRANE ChemPharma & Energy
Omal S.p.A.
Nihon KOSO
Johnson Controls
The subsequent section of the report categorizes the market into type and the application/end-user, This section of the report also highlights the Pneumatic Actuators market, by region, and provides the market outlook for 2014-2026. The study examines the Y-o-Y growth regionally, as well as analyses the drivers that influence the regional Pneumatic Actuators market.
Moreover, for better understanding, the market report offers in-depth research study to understand the market growth based on various analytical methods such as SWOT analysis, and Porter's five analyses. These tools helps to obtain the information appropriate to analyze the forecast economic fluctuations related to the current market growth pattern of the market, which is based on the current data.
Significant Aspects Included in Pneumatic Actuators Market Research Report:
• Manufacturing process and technology used in Pneumatic Actuators market, key developments and trends changing in the development
• A complete investigation, including an evaluation of the parent market
• A comprehensive account of market, volume, and forecast based on leading players, product type and end users/applications
• Environmental spread, pieces of the overall industry, key methodologies, development designs, and different financials systems of Pneumatic Actuators market
• Engineering analysis based on upstream raw materials, downstream industry, current market dynamics, and ensuring consumer's analysis
This report segments the Global Pneumatic Actuators Market on the basis of Types are:
By Product Type
Rack and Pinion
Scotch Yoke
By Capacity
Light Duty
Heavy Duty
By Operation
Double Acting Type
Spring Return Type
On the basis of Application, the Global Pneumatic Actuators Market is segmented into:
Industrial Automation
Oil & Gas
Key Geographical Regions Covered for Pneumatic Actuators Market:
North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia etc.), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)
Important Features that are under Offering and Pneumatic Actuators Highlights of the Reports:
– Thorough overview of Market
– Fluctuating market dynamics of the industry
– In detail market segmentation by Type, Application, etc
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– Potential and niche segments/regions exhibiting promising growth
– Competitive analysis of Pneumatic Actuators Market– Business strategies of Pneumatic Actuators players and product offerings
Inquiry Before Buying @ https://www.apexmarketreports.com/Heavy-Industry/global-pneumatic-actuators-market-by-product-type-by-363298#inquiry
* Reason to Buy
– Showcases key industry priorities to assist organizations to manage their enterprise strategies
– Helps to identify real market opportunities in global Pneumatic Actuators market
– Majorly focuses on supply-demand static, investment feasibleness, and factors that constrain the growth of an industry
– conserve reduce some time Undertaking Entry-level study by identifying the expansion, dimensions, top players and sections in the international Pneumatic Actuators Market
– Summarized worldwide market trends and prognosis along with all the factors driving the current Market, in addition to those endangering it.


text: Seamless palm, sharkskin and shark gel for maximum comfort and protection and pure elite performance. Compact and lightweight, the Maybach has a cuff with more flexibility, thanks to a design called "Dillo-Flex". This wrist combined with a tighter fit gives players greater ability to hinge the wrist for more power behind your shots. SharkGel along the joints hardens upon impact, for flexibility and protection.


text:
Top Five Artistic Photoshop CC Tips and Tricks
Following are five favorite creative and artistic techniques for Photoshop CC. Some of these tricks were developed are tried-and-true helpers that have been around for years.
Smooth skin perfectly
When you see glamour shots, one of the things you're not seeing is the texture of the skin. No wrinkles. No creases. Indeed, the skin appears to be perfectly smooth.
Here's how you can achieve that effect without blurring:
Open a copy of your image.
Add a new layer by clicking the New Layer button in the Layers panel.
Make a selection.
The selection should be away from the face area, and sized at least one-half the width and height of the face.
Fill the selection with color; then deselect.
Press Option+Delete (Mac)/Alt+Backspace (Windows) to fill it with the foreground color.
Select the Healing Brush and set the source point.
Make sure that the Sample: All Layers option is selected in the Options bar and that Aligned is deselected. Option/Alt+click in the center of the filled selection.
Paint over the skin.
In the Layers panel, click on the lower layer — the original image layer — to make it active. Click and drag with the Healing Brush to smooth areas of skin. The Healing Brush replaces the texture of the skin (pores and all) with the texture of the source area (smooth).
Make a photo into a painting
You have dozens of ways to create a "painterly" effect in Photoshop.
Open a copy of your image as a Smart Object.
Select the shadows and blur.
Open the Channels panel and Command/Ctrl+click the channel at the top (RGB or CMYK or Lab) to make a selection according to the brightness of each pixel. Use the shortcut Command+Shift+I/Ctrl+Shift+I to invert the selection (select shadows rather than highlights).
Apply a slight Gaussian Blur, perhaps 1 or 2 pixels, to blur detail in the darker areas.
Select the highlights and sharpen.
You need to reselect the highlights, so again Command/Ctrl+click the channel at the top (RGB or CMYK or Lab). Apply the Sharpen→Smart Sharpen filter with initial settings of Amount: 200% and Radius: 2 pixels.
Add a canvas texture to the image.
Don't deselect. Use the Texture→Texturizer filter to add a slight canvas texture, enhancing the painterly effect.
Create a sketch from a photo
Simulating a painting in Photoshop is great, but sometimes you might need line art or a sketch. Photoshop has a couple of filters that do a nice job of creating pencil sketches, but none of them really do a great job with outlines. Here's an easy way to create line art from a photo.
Open a copy of your image and create a Smart Object.
Apply the Smart Blur filter.
Set the filter to Quality: High and Mode: Normal.
Define edges with Smart Blur.
Reopen the Smart Blur dialog box and set the Mode pop-up menu to Edge Only. Adjust the sliders until the white-on-black preview shows approximately the amount of detail you want in the final image; then click OK.
Invert the colors.
Using the button at the bottom of the Layers panel or the Layer→New Adjustment Layer menu, add an Invert adjustment layer.
Blur the lines.
Click the Smart Object layer again in the Layers panel to make it active and apply a 1- or 2-pixel Gaussian Blur to soften the edges of the lines.
Adjust the thickness of the lines with a Levels adjustment layer.
In the Levels dialog box, drag the middle slider control left and right until you're satisfied with the image's appearance.
Create snow or rain
Here's a multi-use technique that you can use to create falling snow or rain.
Add a new layer to your image by clicking the New Layer button in the Layers panel.
Still in the Layers panel, change the layer's blending mode from Normal to Screen.
Choose Edit→Fill to fill the layer with black.
Because the layer's blending mode is Screen, you won't see the black fill.
Add Noise to the layer.
Use the Noise→Add Noise filter to add some variation to the layer. Use Amount: 20%, Distribution: Gaussian, and mark the Monochromatic check box.
Enlarge the noise with the Crystallize filter.
Use the Pixelate→Crystallize filter to turn the little noise into larger chunks. Use Cell Size: 3 for small snow or rain; try 7 or 10 for larger flakes. You can also apply a slight Gaussian Blur to increase the size.
Sharpen the edges.
Using the Unsharp Mask filter, sharpen until the snowflakes have distinct edges. Use Amount: 100%, Radius: 2, Threshold: 0. When you create rain, use Amount: 40%.
Apply a Levels adjustment.
In the Levels dialog box, drag the middle slider about halfway to the left; then drag the left slider slowly to the right until you see the amount of snow or rain that you want.
Create the Glass Text effect
Perfect for adding a large copyright notice right across the center of your image (while allowing the image's beauty to still show through), this technique is so easy it doesn't even need a step-by-step explanation.
Simply type your copyright info or any other text and add a Bevel and Emboss layer style (perhaps with a slight Inner Shadow and maybe a 1-pixel black Stroke effect). Then, at the top of the Layers panel, reduce the Fill slider (not the Opacity slider) to 0 (zero). The pixels on the layer become transparent, but the layer style remains visible.


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UH Mānoa breaks ground on Translational Health Science Simulation CenterUniversity of Hawaiʻi at Mānoa
Posted: Jan 7, 2011
The UH Mānoa School of Nursing and Dental Hygiene held a groundbreaking ceremony this morning to launch construction of the UH Translational Health Science Simulation Center (UH THSSC). The new $7.5 millioncenter will be established in the School of Nursing and Dental Hygiene, and will serve as a campus hub for interdisciplinary translational health science research, simulation and research education.
Among those in attendance were legislators, UH administrators and major health-care employers – including The Queen's Medical Center, Hawai'i Pacific Health, HMSA Foundation and Kaiser Hawai'i – that have provided gifts to develop the center.
The UH THSSC will be a state-of-the-art facility for clinical simulation for students, educators, practicing health-care providers and researchers.
"This is truly an exciting event because this center will help transform the way Hawai'i's health providers are trained by linking research to bedside care, providing education in state-of-the art facilities, and sharing this technology with the entire State of Hawai'i," said UH Mānoa Chancellor Virginia S. Hinshaw.
Added Dean Mary Boland of the School of Nursing and Dental Hygiene, "With the strong commitment of the University and support from our health-care partners and the community, research-driven and evidence-based practice innovations will flow to practice settings to serve the people of Hawai'i."
Targeted for completion in Fall 2011, the entire 8,500-square-foot floor will be constructed with labs for family assessment, intensive care physiology, acute physiology, community technology, stress/biofeedback, exercise and telehealth, interdisciplinary group areas, interview data acquisition rooms and offices.


text:
Less Sugar, More Vitamins In New Nestle Hot Cocoa Flavors
There's nothing quite so comforting as sitting in front of a fireplace drinking hot cocoa on a chilly evening. Now you have four more flavor options of Nestle Hot Cocoa, which feature less sugar and added nutrients, from Glendale, Calif.-based Nestle USA.
Varieties include: Nestle Hot Cocoa Dark Chocolate, which provides a deep, dark chocolate flavor and contains 25 percent less sugar than the leading brand; Nestle Hot Cocoa Chocolate Caramel offering a smooth, creamy caramel taste paired with a rich chocolate taste and 29 percent less sugar than the leading brand; Nestle Hot Cocoa Chocolate Mint adds the refreshing flavor of peppermint blended with chocolate, with 27 percent less sugar than the leading brand; and Nestle Hot Cocoa Women's Wellness. All Nestle Hot Cocoa flavors are fortified with calcium and are a natural source of antioxidants, and Woman's Wellness, based on the perennial favorite Rich Chocolate flavor, contains added vitamins, making it an excellent source of calcium, antioxidant vitamins A, C and E, vitamins B6 and B12 and iron.
"Sipping from a steaming cup of hot cocoa on a cold winter's day is a great way to chase away the chill of winter," said Chad Patterson, Nestle Hot Cocoa, brand manager. "With our new hot cocoa flavors, we add a bit more variety to this favorite indulgence, while also helping people reduce the amount of sugar they consume and add some helpful nutrients."
Suggested retail price is $1.50-$2.00 per packet.


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|January 25, 1999, 09:07 PM
Join Date: January 24, 1999
Location: Rio de Janeiro, RJ - Brazil
Posts: 50
Hi, Harry
In the thread "Mounting the Long Gun in CQC", you mentioned advancing walk methods that provide a steady shooting platform. Could you please elaborate on those? I believe I've been exposed to the Groucho and the Fencing Step, but I'm afraid I'm not familiar with the SAS way of doing it. Any information would be greatly appreciated.
Leo Daher
|January 26, 1999, 02:40 PM
Staff Alumnus
Join Date: October 13, 1998
Location: Huntington Beach, CA, USA
Posts: 59
Be glad to Leo,
Any fire and movement style that allows for a steady shooting platform is fine if one intends to hit a general area of target mass during tactical movement - call it what you wish (seems that every shooting school has one).
The three methods most commonly taught today are the "Fencing Step", The Groucho (Marks that is) step and the SAS or HK, etc..
Lets explore each:
• Fencing (sometimes called "Blading") step puts the shooter in a bladed position similar to the true Weaver stance or how one would normally mount a shoulder fired weapon. The strong foot remains behind or under the strong shoulder at all times while the weak foot always remains in front of or under the weak shoulder. It is important that the two feet remain separated in the movement plane as well as lateral at least shoulder distance thereby maintaining a wide 3600, balanced base. By shifting the body weight to either foot while advancing or backing with the other, the shooter is able to accomplish a step without rocking off of one foot to the other thus the platform or body torso can remain parallel to the ground during movement while weapon swing is eliminated.. One of the distinguishing advantages of the Fencing step is the inherent advantage created by shifting balance over the stationary foot while moving or committing the other to a direction. This goes a long way in avoiding tripping over the unknown in low light or no light - or when totally focused on the front sight. This is the step of choice for room entry or danger close movement because of the ability to feel with the lead foot before committing to the direction of movement. This step is the only step that should be employed while backing.
• The Gaucho or spread crouch step is more of an open walking movement where both feet advance in a flat footed duck walk manner. The legs are semi crouched and spread slightly wider than shoulder width providing for wide foundation or base during movement. Vertical oscillation of the shooting platform is reduced because of the flat foot placement, i.e. no rolling off the toes and the damping effect created by a slightly crouched stance whereby the shooter is able to absorb any vertical movement by bending the knees. This step is a bit awkward but does allow for rapid movement in open areas where trip obstacles are either not a problem or can be visually acquired and avoided during movement. It is also very stable for large room entries as it places the legs in a natural position to shift immediately into side step or lateral movement down long walls while facing the room.
• The SAS step is basically an open (slightly crouched) advancing step with the torso slightly bent forwards and feet close together. It is the walking version of the open, in tight mount that H&K espouses. It is fast, does not differ from the shooting stance and is comfortable over extended periods of tactical movement. The major disadvantage with this step is the narrow base that is inherent while walking. It is particularly useful in open areas where distance needs to be covered rapidly and, again the trip hazard is not a factor, i.e. hallways warehouses, fields etc. It is not a good system in low light room entries.
[This message has been edited by Harry Humphries (edited 01-26-99).]
|January 26, 1999, 10:49 PM
Join Date: January 24, 1999
Location: Rio de Janeiro, RJ - Brazil
Posts: 50
As always, a very thorough post. Thanks a bunch !
Leo Daher
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flatbed towing Brantford Northeast Ontario Canada
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16 Feb 2017
The underside of a German shepherd, taken in Vancouver, Canada, December 2016.
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text:
Latest sample galleries
Latest in-depth reviews
Weighing in at just 249g, the Mavic Mini fits in the palm of your hand. You give up a few features in exchange for that tiny size, but we still found it to be a solid performer.
The Epson V600 is a reasonably priced scanner aimed at analog film shooters. It's fairly easy to operate and capable of decent image quality, but still easily bested by scans from our local photo lab.
The EOS M200 is Canon's new entry-level mirrorless camera. It's easy to use, takes great photos, and crams a big APS-C sensor into one of the smallest camera bodies on the market. We think that's a recipe for success – get all the details in our full review.
Sony's a6100 adds powerful autofocus and a touchscreen to its low-cost mirrorless camera. But little inconsistencies mean it's not quite the excellent beginners camera it could be.
The Olympus OM-D E-M5 Mark III is a 20MP Micro Four Thirds camera aimed at enthusiast photographers. It shares the same sensor, AF system and 4K-video capture as the flagship E-M1 II and E-M1 X, in a considerably smaller and lighter package.


text:
Middle East respiratory syndrome- coronavirus - update
29 May 2013 - The Ministry of Health in Saudi Arabia has notified WHO of an additional five laboratory-confirmed cases with Middle East respiratory syndrome coronavirus (MERS-CoV).
All five patients are from the Eastern region of the country, but not from Al-Ahsa, where an outbreak began in a health care facility in April 2013. The patients had underlying medical conditions which required multiple hospital visits. The government is conducting investigations into the likely source of infection in both the health care and the community settings.
The first patient is a 56-year-old man with underlying medical conditions, who became ill on 12 May 2013 and died on 20 May 2013. The second patient is an 85-year-old woman with underling medical conditions who became ill on 17 May and is currently in critical condition. The third patient is a 76-year-old woman with underlying medical conditions who became ill on 24 May 2013 and was discharged from the hospital on 27 May 2013. The fourth patient is a 77-year-old man with underlying medical conditions who became ill on 19 May and died on 26 May 2013. The fifth patient is a 73-year-old man with underlying medical conditions who became ill on 18 May and died on 26 May 2013.
Additionally, a patient earlier reported from Al-Ahsa, an 81-year-old woman has died. The government is continuing to investigate the outbreaks in the country.
In France, the first laboratory-confirmed case in the country, with recent travel from the United Arab Emirates has died.
Globally, from September 2012 to date, WHO has been informed of a total of 49 laboratory-confirmed cases of infection with MERS-CoV, including 27 deaths.
WHO has received reports of laboratory-confirmed cases originating in the following countries in the Middle East to date: Jordan, Qatar, Saudi Arabia, and the United Arab Emirates (UAE). France, Germany, Tunisia and the United Kingdom also reported laboratory-confirmed cases; they were either transferred for care of the disease or returned from the Middle East and subsequently became ill. In France, Tunisia and the United Kingdom, there has been limited local transmission among patients who had not been to the Middle East but had been in close contact with the laboratory-confirmed or probable cases.
Based on the current situation and available information, WHO encourages all Member States to continue their surveillance for severe acute respiratory infections (SARI) and to carefully review any unusual patterns.
Health care providers are advised to maintain vigilance. Recent travellers returning from the Middle East who develop SARI should be tested for MERS-CoV as advised in the current surveillance recommendations. Specimens from patients' lower respiratory tracts should be obtained for diagnosis where possible. Clinicians are reminded that MERS-CoV infection should be considered even with atypical signs and symptoms, such as diarrhoea, in patients who are immunocompromised.
Health care facilities are reminded of the importance of systematic implementation of infection prevention and control (IPC). Health care facilities that provide care for patients suspected or confirmed with MERS-CoV infection should take appropriate measures to decrease the risk of transmission of the virus to other patients, health care workers and visitors.
All Member States are reminded to promptly assess and notify WHO of any new case of infection with MERS-CoV, along with information about potential exposures that may have resulted in infection and a description of the clinical course. Investigation into the source of exposure should promptly be initiated to identify the mode of exposure, so that further transmission of the virus can be prevented.
WHO does not advise special screening at points of entry with regard to this event nor does it currently recommend the application of any travel or trade restrictions.
WHO continues to closely monitor the situation.


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Early signs of spring in Barcelona
Written by Lucy Brzoska
The sound of serins pouring out their song means spring has arrived in Barcelona. This male was glowing from his tree top perch, almost as yellow as a canary, the serin's close relative.
In a corner of Montjuic's botanical gardens, ruderal plants explode in flower: citadels of asphodel arise among lagoons of common borage.
Montjuic's cable cars are in motion, after their annual February check-up and clean, and long queues of tourists form again. Starlings nest inside the metal towers, unbothered by the noise and moving machinery.
In the few calcareous areas of Collserola, thyme flourishes, and when its first flowers appear in March, so does a diminutive blue butterfly. The Panoptes blue (Pseudophilotes panoptes), native to Iberia and north Africa, favours thyme as a food plant and source of nectar.


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With two days remaining for early voting in the Cape Coral City Council Primary Election, and Election Day Tuesday, people haven't exactly been beating down the doors for their opportunity to vote.
At least not yet.
The Cape Coral Elections Office branch at 1031 S.E. 9th Place has barely registered a trickle of voters looking to vote for candidates for mayor or in District 1, the two races on the primary ballot.
As of Thursday afternoon, 1,092 voters came to vote in person. That is fewer than the 1,309 absentee ballot requests that have been received, with just 465 returned so far.
The deadline to request an absentee ballot was Wednesday.
City Clerk Rebecca van Duetekom said it's too early to glean anything from the numbers.
"I can't tell if it's keeping with our standard returns or not. I'm not familiar where we would be at this point," van Duetekom said. "Maybe some people want to wait until voting day. Some people don't want to early vote."
In 2011, 11.1 percent of registered voters cast ballots - 10,355 out of 92,995 eligible voters cast a ballot, with 2,908 voting early and 1,242 casting absentee ballots.
Early voting continues today from 9 a.m. until 5 p.m., and Saturday from 10 a.m. until 6 p.m. at the office in Cape Coral or at the Constitutional Complex at 2480 Thompson St. in Fort Myers on the 3rd floor.
The lack of turnout for local elections baffles Lee Elections Supervisor Sharon Harrington.
"I always say that your city government is the only people you have the best access to if you need something," Harrington said. "The further out you go, the bigger the issue is, the less they're going to listen to you."
Van Duetekom echoed those sentiments, saying that primary election serves its purpose.
"No matter if you vote early or in the precinct, we need to encourage people to vote and be engaged," Van Duetekom said. "Some people may not see the importance of the primary or reducing the field."
This primary election, six candidates are running for the mayor's seat - Daniel "Dan" Ashby, Alan "A.J." Boyd, David P. Carr, Vincent A. Cummings, Marni Lin Sawicki and incumbent John J. Sullivan.
Four are running for the District 1 council seat - James "Jim" Burch, Steven L. Golub, David R. Headd and Graham Madison Morris. The seat has no incumbent as Councilmember Marty McClain is not seeking re-election.
The top two vote getters in each non-partisan race will advance to the general election, which will also feature the District 4 and 6 seats, in November.
All registered voters can vote in every race on the ballot in both the primary and the general election: City council races are non-partisan, and all council members are elected citywide, although officials must live in the district they represent.
For more information you can log onto the Lee County Elections Website, www.leeelections.com or the city Website, capecoral.net.


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Writing and afterlight your résumé is a assignment that few of us enjoy. Microsoft is acquisitive to accomplish it a little beneath aching with a new affection advancing to Word alleged Resume Assistant.
Resume Assistant will ascertain that you're autograph a résumé and action insights and suggestions adopted from LinkedIn. LinkedIn is a all-inclusive athenaeum of both résumés and job openings and lets you see how added bodies call their skillsets and which abilities administration are attractive for.
The affection will additionally appearance job openings that are acceptable for your résumé anon aural Word, putting résumé writers anon in acquaintance with recruiters.
Matching up job applicants with recruiters is LinkedIn's better acquirement generator, and amalgam Word into this business was one of the actual priorities that Microsoft CEO Satya Nadella declared back answer the purchase. In accession to stering that recruiting business, the affiliation is monetized added directly, too, as Resume Assistant has some admission to paid services. Specifically, it can advance online training through LinkedIn Learning to advice bank up any gaps. If you appetite added advice than the automatic suggestions can offer, LinkedIn can affix you to professional résumé autograph casework through its freelance marketplace.
With Word consistently acclimated for writing résumés, there's a accustomed fit with LinkedIn's business. Nadella has said that growing LinkedIn's acquirement is the actual antecedence for Microsoft. Joining Word with the amusing arrangement will advice to do this; absolution bodies administer for jobs and added casework aural Word cuts out the hurdle of accepting to use the site, and it should appropriately beggarly that added bodies absolutely administer for those jobs.
The Resume Assistant will become accessible to Office 365 users that accept autonomous in to the Insider aboriginal admission affairs on Thursday. Initially, it will alone assignment in English-language Windows, to users in Australia, Brazil, Canada, China, France, Germany, India, Ireland, Japan, Singapore, South Africa, Spain, New Zealand, the United Kingdom, and the USA. Microsoft will again cycle it out to added Office 365 users added broadly over the aing few months
Why It Is Not The Best Time For How To Create A Resume Link | How To Create A Resume Link – how to create a resume link
| Encouraged to my personal website, in this particular moment I'm going to provide you with concerning how to create a resume link


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This year Alexis is using her best developed and most cherished skill-the art of the life-changing workshop-to raise funds to support her decision to spend the next year doing the MobileHomeComing an immersive intergenerational community documentation and education project based on her lust for back queer community! (It's weird that somehow I have to be consistent with a choice to talk about myself in the third person here, but I want to interject in the first person to say that your support means everything to me and it is evidence of the fact that it is possible to be a community supported, community accountable scholar in the 21st Century. :)
Bring Alexis to your campus, community center, to speak, or do a workshop that you will never forget!
Alexis is available to speak on a variety of topics and has tons of experiences speaking to audiences at elementary schools, college campuses, community centers, rallies, conferences and workshops. Click on the links for examples of public talks she has given in the past. She might particularly be a great person to complement your community or campus programming during Sexual Assault Awareness Month, Love Your Body Week, Celebration of Black Womanhood Week, Black Heritage Month, Women's History Month, National Coming Out Day, Mother's Day or throw tokenism to the wind and bring Alexis to speak and make any old day of the year a day filled with hope and magic!
Alexis's Academic CV
(Most workshops are available either as a one time session, a day-long intensive or a series within the NC Triangle or Triad areas. Get in touch about what works best for your community. Below are workshops that I have facilitated many times before. I can also design workshops specifically for your needs :)
Pressed for Knowledge: Alexis has facilitated this miraculous zine making workshop all over the United States in communities, on college campuses and at conferences. In this workshop participants (whether they are part of an existing group or are meeting for the first time on the day of the workshop) use the resources of urgency, homegrown brilliance and whatever's around to create their own publication in less than 2 hours. Alexis leads participants in a process of choosing an audience, a theme that connects their passions and a work structure and a group evaluation process for their own urgent publication! (NEW!!! Pressed for Knowledge is now available in a video version...where participants create and edit their own video in an amazingly short period of time!)
Grassroots Literary Production: Due to her experience leading the Pressed for Knowledge workshop and facilitating students at Duke University, UNC-Greensboro and the SpiritHouse Choosing Sides program in the creation of their own online and print collaborative publications, Alexis can train teachers, faculty and community cultural workers to make publication a part of their programming.
The Activist Impulse: Similar to the Pressed for Knowledge Workshop, this workshops leads participants through a process of deciding on, designing and enacting and evaluating a site-specific direct action. Alexis has led this workshop with a class of Duke University Students, at the Ethnic Studies and the Activist Impulse Symposium at Columbia University, the Beyond the Box Conference at Barnard College, the Anarchist People of Color SouthEast Regional Conference and more!
(These workshops are grounded in Alexis's years of black feminist research and spiritual practice and are ideal for a community organization, school, department or group of people interested in how the theory, practice, poetry and lessons of black feminist practice apply to their present conditions)
Letters to Audre: developed in a special writing enrichment course that Alexis designed for Africana Women's Studies majors at Bennett College for Women, this workshop or series of workshops introduces participants to key works by black feminist lesbian poet, scholar, activist Audre Lorde. Participants create their own versions of/responses to poems and essays by Audre Lorde including Litany for Survival and The Uses of Anger. Participatns also write their own poetic letters to this literary feminist ancestor. See www.letterstoaudre.wordpress.com for examples. Alexis is also available to lead seminars for faculty, teachers, and community educators on Teaching Audre Lorde.
Letters to June: Along a similar model as the Letters to Audre Workshop, this curriculum was developed for a feminist theory course at UNC-Greensboro. Participants will write their own "Poem About My Rights" and "What's Love Got to Do With It" and also engage some of Jordan's lesser known and unpublished pieces. Alexis is also available to use her privileged access as the first researcher to view June Jordan's archival papers to lead seminars on Teaching June Jordan.
Litany for Survival: The Poetics of Community Building This writing and movement workshop, designed in collaboration with Ebony Golden starts from the grounding point of Audre Lorde's Litany for Survival and leads participants through a process of analyzing the poem for themselves, using theater of the oppressed methodologies to demonstrate what survival means for them and creating their own praise poems towards the survival of their own communities. This workshop was debuted at the Brecht Forum in New York City with an amazing response.
In Your Hands: The Depth of Legacy: based on a spiritual experience that Alexis had of recieving and writing down letters from chosen, (and uninvited!) black feminist ancestors including Fannie Lou Hamer, Nayo Watkins, Toni Cade Bambara, Octavia Butler and her own grandmother (see the letters and the video documentation of the process here) this workshop is designed to facilitate participants in listening for and to the legacies of their own chosen traditions. Alexis will facilitate a disucssion of some of the insights in the letters she recieved and each participant will leave with a plan and a way to make space for their own insights.
(these workshops are designed to keep community members, community organizers, students and teachers ALIVE AND WELL with full access to their love for themselves, each other and their inspired purpose!)
Habit Forming Love: This workshop shares the gifts of a 21 day process in which Alexis sought to learn how to love herself, her partner and her community better and to train herself in online video production and distribution. Available as a one time workshop or a skills building series, this workshop will allow participants to use new media technology to deepen and activate their love for themselves, their chosen family and their communities. Browse Alexis's video project here.
Mother Ourselves: Created in collaboration with Zachari Curtis for the Gumbo Yaya Sister Circle, and inspired by Audre Lorde's essay "Eye to Eye," this workshop provides participants with a safe space to examine their thoughts about the meaning of "mothering," and allows participants to explore what it might mean to nurture, teach and transform themselves. In this workshop we work in partners, listen to our bodies, use mirrors and talk about the affirming and difficult process of reflections linked to our varied experiencs with mothering.
Sustainability for Organizers and Activists: The workshop, designed for (and with) the organizers and visionaries in Critical Resistance, is about ENDING ACTIVIST BURN OUT!!!! Remembering that we, our bodies and our spirits are the most important resources for change, this workshop facilitates organizers in identifying the resources that keep them inspired and practices that can keep/get us well. Every participant leaves with their own visible reminder of their own wellness insights!
(These workshop are ideal for a community organization/project/coalition at a stage of inception or renewal.)
Dig: Grounding Community Transformation in Local Resources
Based on Alexis's poem dig, this workshop is designed to get community members in touch with the secrets, issues, and resources in their own communities and to build a shared analysis of those resources as a guide for their community projects and alliances. Each community will leave with at the very least, a group poem, new clarity about their resources and projects that connect and align their existing resources. The "dig" exercise has been enacted in Greensboro, Miami, Asheville and Gainesville as part of the Grassroots Media Justice Tour.
Wishful Thinking: Vision and Actualization Based on Alexis's poem in honor of black women and survivors of sexual violence in her community and recorded as a track on the SPEAK! CD this workshop leads participants through a meditation about their desires for their local communities and communities of affinity. Participants will leave with a community wishlist and individual affirmations. To see some of the results of the version of Wishful Thinking facilitated with the Speak Media Collective at the Women and Action in the Media Conference see www.wakeupnew.blogspot.com.
Support the Work:
(all proceeds go towards Alexis's work on the mobilehomecoming project and do not include travel and accomodation. Priority will be given to institutions in Lex's home region of the North Carolina Triangle and Triad areas.)
Colleges and University-$1000 for lecture or poetic performance ($2500 for a lecture or poetic performance, Q&A and an additional classroom visit)
Community Center/Non-profit- $200-300 for lecture ($500 for lecture and workshop)
Autonomous Community Spaces (independent bookstores, churches etc.)- $100 for lecture(with the possibility of just passing the hat if we can also have publications for sale)
( each workshop will result in a publication/poem/major accomplishment for participants to keep and for the sponsor to be proud of!):
Colleges and Universities- $1000 ($3500 for a series)
Community Center/Non-profit- $300-500 (discounts for smaller or rural orgs, talk to me) ($850-1000 for a series)
Living Rooms/Kitchen Tables- $100 or gather your people, pass the hat and have some yummy food on hand and I'm there!!! (maybe I was a travelling black feminist preacher in a past life...)
All suggested prices are really suggested. Get in touch. (email@example.com)
We can work something out.


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Vorinostat and Lenalidomide in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01116154
Recruitment Status : Terminated (Sponsor withdrew support for the study)
First Posted : May 4, 2010
Last Update Posted : December 9, 2010
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
RATIONALE: Vorinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Biological therapies, such as lenalidomide, may stimulate the immune system in different ways and stop cancer cells from growing. Giving vorinostat together with lenalidomide may kill more cancer cells.
PURPOSE: This phase I trial is studying the side effects and best dose of vorinostat when given together with lenalidomide in treating patients with relapsed or refractory Hodgkin lymphoma or non-Hodgkin lymphoma.
|Condition or disease
|Adult Nasal Type Extranodal NK/T-cell Lymphoma Anaplastic Large Cell Lymphoma Angioimmunoblastic T-cell Lymphoma Cutaneous B-cell Non-Hodgkin Lymphoma Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue Hepatosplenic T-cell Lymphoma Intraocular Lymphoma Nodal Marginal Zone B-cell Lymphoma Peripheral T-Cell Lymphoma Post-transplant Lymphoproliferative Disorder Recurrent Adult Burkitt Lymphoma Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Adult Diffuse Small Cleaved Cell Lymphoma Recurrent Adult Grade III Lymphomatoid Granulomatosis Recurrent Adult Hodgkin Lymphoma Recurrent Adult Immunoblastic Large Cell Lymphoma Recurrent Adult Lymphoblastic Lymphoma Recurrent Adult T-cell Leukemia/Lymphoma Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Recurrent Mycosis Fungoides/Sezary Syndrome Recurrent Small Lymphocytic Lymphoma Small Intestine Lymphoma Splenic Marginal Zone Lymphoma Testicular Lymphoma Waldenstrom Macroglobulinemia
|Drug: lenalidomide Drug: vorinostat Other: laboratory biomarker analysis
|Phase 1
I. To assess the safety and tolerability of the combination of lenalidomide and vorinostat.
II. To determine the maximum tolerated dose (MTD) and recommended dose of vorinostat and lenalidomide when given in combination in this patient population.
I. To obtain preliminary data for response rate, time to response, response duration and time to progression (TTP) for vorinostat and lenalidomide when used in combination.
OUTLINE: This is a dose-escalation study of vorinostat.
Patients receive oral vorinostat twice daily on days 1-14 and oral lenalidomide once daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed every 3 months.
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|30 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Phase I Study of the Combination of Lenalidomide With the Histone Deacetylase Inhibitor, Vorinostat in Hodgkin and Non Hodgkin's Lymphoma
|Study Start Date :
|May 2010
|Actual Primary Completion Date :
|July 2010
|Actual Study Completion Date :
|August 2010
Experimental: Arm I
Patients receive oral vorinostat twice daily on days 1-14 and oral lenalidomide once daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Drug: lenalidomide
Given orally
Other Names:
Drug: vorinostat
Given orally
Other Names:
Other: laboratory biomarker analysis
Correlative studies
- Assessment of the Maximum Tolerated Dose and Dose-Limiting Toxicities of the combination of vorinostat and lenalidomide in this patient population [ Time Frame: Following Cycle 1 of treatment ]
- Number of patients with Grade 3 or above adverse events [ Time Frame: Day 8 and 22 of Cycle 1 and Day 1 of subsequent cycles and Day 30 following the last dose of study drug ]
- Duration, intensity, and time to onset of toxicities [ Time Frame: Day 8 and 22 of Cycle 1 and Day 1 of subsequent cycles and Day 30 following the last dose of study drug ]
- AE, laboratory safety assessments, ECOG, ECGs, vital signs, transfusions, hospital days, and antibiotic use [ Time Frame: Day 8 and 22 of Cycle 1 and Day 1 of subsequent cycles and Day 30 following the last dose of study drug ]
- Objective response rate [ Time Frame: Every nine weeks on therapy after 2 years a minimum of every 6 months ]
- Time to response [ Time Frame: Every nine weeks on therapy after 2 years a minimum of every 6 months ]
- Response duration [ Time Frame: Every nine weeks on therapy after 2 years a minimum of every 6 months ]
- Progression-free survival [ Time Frame: Every nine weeks on therapy after 2 years a minimum of every 6 months ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- Understand and voluntarily sign an informed consent form
- Able to adhere to the study visit schedule and other protocol requirements
- Patients must have a history of biopsy-documented Hodgkin or non-Hodgkin lymphoma (either B or T cell) and with relapsed or refractory disease after at least one prior line of therapy
- All previous cancer therapy, including radiation, hormonal therapy and surgery, must have been discontinued at least 4 weeks prior to treatment in this study
- Patients must have measurable disease by CT scan; PET scans are desirable but not mandatory, so that patients with negative PET scans but measurable disease by CT are eligible
- Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2 at study entry
- Patients may be enrolled who relapse after autologous stem cell transplant or after allogeneic transplant; they must have no active related infections (i.e., fungal or viral), no acute graft versus host disease (GvHD) of any grade, and no chronic GvHD other than mild skin, or, or ocular GvHD not requiring systemic immunosuppression
- Laboratory test results within these ranges:
- Absolute neutrophil count >= 1,000/mm^3
- Platelet count >= 75,000/mm^3
- Serum creatinine =< 1.5 mg/dL
- Total bilirubin <= 1.5 mg/dL (however, patients with elevation of unconjugated bilirubin alone, as in Gilbert's disease, are eligible)
- AST (SGOT) =< 2 x upper limit of normal (ULN)
- ALT (SGPT) =< 2 x ULN
- Disease free of prior malignancies for >= 5 years with exception of currently treated blast cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix
- All study participants must be registered into the mandatory RevAssist program and be willing and able to comply with the requirements of RevAssist
- Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 50 mIU/ml within 10-14 days prior to and again within 24 hours of prescribing lenalidomide (prescriptions must be filled within 7 days) and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control-one highly effective method and one additional effective method AT THE SAME TIME-at least 28 days she starts taking lenalidomide; FCBP must also agree to ongoing pregnancy testing; men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy
- Able to take aspirin or low molecular weight heparin as prophylactic anticoagulation
- Life expectancy greater than 3 months
- Able to swallow enteral medications
- Any serious medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from signing the informed consent form
- Pregnant or breast-feeding females; lactating females must agree not to breastfeed while taking lenalidomide
- Any condition, including the presence of laboratory abnormalities, that places the subject at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study
- Use of any other experimental drug or therapy with 28 days of baseline
- Known sensitivity to thalidomide or histone deacetylating agents
- The development of erythema nodosum if characterized by a desquamating rash while taking thalidomide or similar drugs
- Any prior use of lenalidomide, vorinostat, or other histone deacetylase inhibitors other than valproic acid, which must be stopped 2 weeks prior to study unless being used for seizure control
- Concurrent use of other anti-cancer agents or treatments
- Known positive for HIV or infectious hepatitis type B or C
- Patients with known brain/CNS metastases
- Patients with feeding tubes
- Any history of deep vein thrombosis (DVT) or pulmonary embolism (PE)
- Any current infection requiring the use of antibiotic, antiviral, or antifungal medication
- Any uncontrolled dysrhythmias
- Baseline QTcF interval > 500 msec in the absence of correctable electrolyte imbalance or any patient with a congenital history of QTc prolongation
- Current therapeutic anti-coagulation
- Any contraindication to safely using prophylactic anticoagulation
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01116154
|United States, California
|City of Hope
|Duarte, California, United States, 91010
|Principal Investigator:
|Leslie Popplewell
|City of Hope Medical Center
|Responsible Party:
|Popplewell, Leslie, City of Hope
|ClinicalTrials.gov Identifier:
|NCT01116154 History of Changes
|Other Study ID Numbers:
NCI-2010-00947 ( Registry Identifier: NCI CTRP )
|First Posted:
|May 4, 2010 Key Record Dates
|Last Update Posted:
|December 9, 2010
|Last Verified:
|December 2010
Leukemia, Lymphocytic, Chronic, B-Cell
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, T-Cell
Leukemia-Lymphoma, Adult T-Cell
Leukemia, B-Cell
Leukemia, Lymphoid
Burkitt Lymphoma
Lymphoma, Follicular
Lymphoma, Non-Hodgkin
Lymphoma, B-Cell
Hodgkin Disease
Lymphoma, Mantle-Cell
Lymphoma, B-Cell, Marginal Zone
Lymphoma, Large B-Cell, Diffuse
Lymphoma, T-Cell
Lymphoma, Large-Cell, Immunoblastic
Plasmablastic Lymphoma
Mycosis Fungoides
Sezary Syndrome
Lymphoma, T-Cell, Cutaneous
Waldenstrom Macroglobulinemia
Lymphoma, Large-Cell, Anaplastic
Lymphoma, T-Cell, Peripheral
Lymphomatoid Granulomatosis
Lymphoma, Extranodal NK-T-Cell
Intraocular Lymphoma


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Supply Chain
Each year M.A.G procures a diverse range of goods and services directly through our Supply Chain. Therefore, we have various new business opportunities available to suppliers.
For more information on tenders and tender opportunities and for services that our supply chain team can provide please visit our MAG World site.


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Players of the Week - No. 10
Fenlason, a 6-foot-1 senior goalkeeper, was stout on the defensive front in a pair of Golden State Athletic Conference (GSAC) tournament road shutouts last week. In the 1-0 victory over Vanguard (Calif.) on Nov. 2, the native of Rancho Bernardo, Calif., finished with four saves in 90 minutes as he faced 14 overall shots. The blanking was only the third for Vanguard this year (in 19 matches) and the Eagles first win at Vanguard since 2002. On Nov. 5, Fenlason posted three saves in the 1-0 triumph over GSAC regular-season champion Fresno Pacific (Calif.). Fenlason has allowed two goals over the past five games as Biola has won five-straight matches.
Ramirez, a 6-foot-2 junior forward, notched seven points in a 2-0 week for the Eagles in the GSAC tournament. The native of Garden Grove, Calif., either scored the goal or had an assist in five of the six team goals. He found the net twice in the 2-1 victory over The Master's (Calif.) on Nov. 2 and then recorded three helpers in the 4-2 win against No. 10 Azusa Pacific (Calif.) on Nov. 5. In the NAIA, he ranks sixth in total points (47) and 10th in total goals (18).
Offensive Nominees: Julio Rodarte, Oklahoma Wesleyan; Robert Als, Cumberland (Tenn.); Achille Campion, Belhaven (Miss.); Geraldo Garza, Ashford (Iowa); Tyler Fischer, Aquinas (Mich.); Danny Cawley, Taylor (Ind.); Billy Forbes, Lubbock Christian (Texas); Dominic Coco, Roberts Wesleyan (N.Y.); Sandre Wilson, Milligan (Tenn.); Richard Isberner, Rio Grande (Ohio); Edgar Esquivel, Northwest (Wash.); Mike Tobie, Judson (Ill.); Jordan Green, Hastings (Neb.); Liam Whelan, Holy Names (Calif.).
Defensive Nominees: Lucas Sagaert, Siena Heights (Mich.); Adam Lewis, Mid-Continent (Ky.); Brad Miller, Olivet Nazarene (Ill.); Hector Herrera, Oklahoma Wesleyan; Daniel James, Ashford (Iowa); Josh Giuliano, Taylor (Ind.); Erik Read, Roberts Wesleyan (N.Y.); Billy Sparks, Tennessee Wesleyan; Yuta Nomura, Lindsey Wilson (Ky.); Jeremy Swift, Rogers State (Okla.); Joe Galbraith, Northwest (Wash.); Alex Palomarez, Menlo (Calif.); Cody Poteat, Hastings (Neb.).
2011 Men's Soccer Players of the Week (Offensive; Defensive)
Week 1: Billy Forbes, Lubbock Christian (Texas); Zack Schultze, Reinhardt (Ga.)
Week 2: Trent Remmich, MidAmerica Nazarene (Kan.); Sam Winstanley, Illinois Tech
Week 3: Lebogang Moloto, Lindsey Wilson (Ky.); Cody Poteat, Hastings (Neb.)
Week 4: Veit Couturier, Embry-Riddle (Fla.); Will Akers, Cal Maritime
Week 5: Eddy Campbell, Lindsey Wilson (Ky.); Collin Cone, Grace (Ind.)
Week 6: Paul Islas, Fresno Pacific (Calif.); Steven Waite, Fresno Pacific (Calif.)
Week 7: Nate Polak, Hastings (Neb.); Alex Palomarez, Menlo (Calif.)
Week 8: Bill Jeffries, Lyon (Ark.); Josh Putz, Mount Mercy (Iowa)
Week 9: Greg Hartley, Belhaven (Miss.); Deshorn Brown, Mobile (Ala.)
Week 10: Christian Ramirez, Concordia (Calif.); Aaron Fenlason, Biola (Calif.)


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1989 Chevrolet C1500 Project Rehab: Serious Small-Block Part 1
Building a Potent 383ci Stroker With Parts From Edelbrock, SCAT, and Summit Racing
The venerable Chevy 350 can be found at the heart of nearly four decades of GM vehicles, and as a result it has been built and modified in just about every way imaginable. Some may claim it's played out, and that the LS engines are vastly superior, but Gen I small-blocks are still very popular. So, to prove the small-block can still hold its own, we made a few phone calls to aftermarket parts suppliers to create a legit powertrain. SCAT Crankshafts sent us a complete 383ci stroker rotating assembly (PN: 1-92302BIE), which includes the crank, I-beam rods, hypereutectic pistons, rings, and bearings. Edelbrock was our one-stop shop for all the top end parts we needed, including their 460hp-rated Power Package Top End Kit (PN: 2096). Finally, Summit Racing supplied us with their Pro Pack oil pan kit (PN: SUM-PANKIT8), and Professional Products sent over an 8-inch harmonic balancer (PN: 8002).
For those unfamiliar with the concept of a stroker build, you probably know it means more power, but you might not know how that's accomplished. By using a larger 3.75-inch crankshaft compared to the factory 3.48-inch, the pistons are able to travel further up and down within the cylinders, resulting in increased stroke. This, along with a set of larger-diameter pistons, creates more volume in each cylinder, meaning a bigger overall displacement. With the addition of a new crank, larger pistons, and boring the block, our 350ci engine gains 33 cubes and becomes a 383ci "stroker."
With an old donor long-block and our shiny new parts in hand, we headed to L&R Engine in Santa Fe Springs, California. Having built countless high-performance engines for several magazines and even the TV show Overhaulin, the guys at L&R had the experience and know-how we needed to bring it all together. We've got big plans for this motor under the hood of Project Rehab, our '89 C1500 performance truck build, so read on to see how we created a small-block that can go head-to-head with any modern LS engine.
Summit RacingAkron, OH
Professional ProductsHawthorne, CA 90250
Scat CrankshaftsRedondo Beach, CA 90278
L&R EnginesSanta Fe Springs, CA 90670
EdelbrockTorrance, CA 90503


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Last month we left off with putting the final touches on the frame of my '33 at Circle City Hot Rods in Orange, California. To date, that portion has consumed the most time, with extensive labor having been dedicated to boxing (and finishing) nearly both full lengths of each 'rail, not to mention the first rounds of squaring everything up (further leveling/squaring continues with the suspension setup, which we'll now address).
With the perimeter frame together, Jimmy White and I embarked upon installing and initially setting up the suspension. Now, if you know me at all, you know I'm a solid axle kind of guy, especially on open-wheeled cars as such. (That said, I just got done driving the STREET RODDER 2008 Road Tour '33 roadster roughly 40 miles—and it was anything but rough, as it's equipped with an independent frontend. Even with Coker's ribbed Firestone bias-plies, I will admit, the ride was quite pleasing, very smooth, and basically nothing like the hot rod experience I'm used to. However, I won't be making future plans of swapping the I-beam on my '33 for an IFS anytime soon!) Solid axles—I-beams, specifically—go hand in hand with hairpins and split wishbones, and seeing as I've never fooled around with the latter, 'bones it be for me this go around.
Initially, Alan Johnson was more than gracious in allowing me to experiment with his Hot Rod Hole Shot aluminum radius rods/ladder bars from his shop's new(er) line of Perfection Hot Rod Parts. Both styled after traditional Ford split wishbones, the rear ladder bars are fairly universal fitment-wise; the radius rods, however, were designed on a Deuce frame platform, which eventually posed a slight issue with the framerail mounting. Due to the '33-34 'rail kicking up further back, closer to the firewall than a '32, in order to attain the desired amount of caster, we'd have had to mount the tie-rod ends hanging far below the bottom of the framerail. Another option would've been cutting the fixed-end tie rod off and drilling/tapping the radius rod for an adjustable end, but that's not how Johnson designed them, and I'm not in favor of redesigning his parts! So, that said, we resorted to our third option—using Speedway's longer steel wishbones. (It's a bit of a shame that the rear ladder bars are more out of sight, but that's just another reason not to run the stock gas tank!) The front suspension consists of Chassis Engineering's forged dropped axle, spindles, transverse leaf, and stainless perches, all residing below Speedway's '33-34-ish crossmember. We'll address the rear suspension in next month's installment.
Lastly, I've elected to buck the advice of my elders and run drum brakes—at all four corners. Similar to my preference for bias-ply tires, I realize the limitations and drive accordingly—but by paying more attention, I feel that I'm a safer driver behind the wheel of an old car than most driving modern cars that do everything for them, leaving them to their social media habits more than watching the road. Speedway's Lincoln-styled 12-inch hydraulic binders will slow the front; at the rear, 11-inch Ford drums capping the steel axle tubes of a Winters banjo.
Alright, enough talking—let's get on with the building.
1 As noted, the frontal group entails one of Chassis Engineering's finely forged dropped I-beams and multi-leaf '33-34 spring.
2, 3 In order to properly set the entire suspension up, it would first need to be loosely assembled, then put under a load to achieve desired ride height.
4 Once assembled and loaded, we could commence with the fine-tuning and set both ride height and caster (camber's already built into the axle, obviously).
5, 6 Squaring and leveling were just part of the procedure …
7 … the spring shackles also need to be within a certain limit angle-wise to ensure sufficient/correct spring travel.
8 It was at this point that we determined the shorter radius rods from Johnson's Hot Rod Shop (designed to fit a '32 frame "fixed length") were just a tad short for our '34 chassis …
9, 10 … but short enough not to allow enough axle caster (just 3 degrees if we mounted them to the bottom of the frame)—that is, unless a heavily dropped mount was used in the rear, which to us seemed to welcome potential clearance issues rather than solve the initial problem.
11 So, despite the desire to retain the Hot Rod Hole Shot radius rods, the solution was not to cut them up (and fashion an adjusted rod end to compensate for length), rather, utilize a set of Speedway's steel-tube split wishbones instead.
12, 13 As with literally everything else, Jimmy White pursued the alternative option by first leveling and squaring up the tie-rod mounts for the longer suspension arms.
14 Once set, we now had 7 degrees of caster in the axle, which will now ensure correct steering and travel.
15 Again, White made sure the mounts (which he'd just whipped up from plate steel) were even side-to-side prior to welding in place.
16 Again, White made sure the mounts (which he'd just whipped up from plate steel) were even side-to-side prior to welding in place.
17 And with that, the front suspension is good to go, save of course for connecting a few weld lines here and there. Next month we'll tackle the rear—without having to sacrifice a beautiful set of aluminum wishbones/ladder bars in the process!


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The IFSC Code of Co-operative Banks Bo Kalpa branch is YESB0HPB252. The branch is located in Kinnaur district of Himachal Pradesh. For address and phone numbers, scroll down.
Co-operative Banks Bo Kalpa IFSC Code: YESB0HPB252
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Co-operative Banks Bo Kalpa MICR & Contact Info
Address, MICR code, branch contact number etc of Co-operative Banks Bo Kalpa branch is given below. You may contact the branch or the Customer Care number of the bank information relating to your Co-operative Banks account.
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The HP State Co-operative Bank Bo Kalpa Kalpa, Kinnaur - 172108
City : Kalpa
District : Kinnaur
State : Himachal Pradesh
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Co-operative Banks branches in Kinnaur | Co-operative Banks branches in Himachal Pradesh
Along with your account number, account name and account type (ie., savings or current) the following information about the branch is to be provided for fund transfer:
Bank Name : Co-operative Banks
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IFSC Code : YESB0HPB252
Location : Kalpa, Kinnaur, Himachal Pradesh - View full address & contact number
To make NEFT or RTGS money transfer to Co-operative Banks Bo Kalpa branch from any other bank in India, IFSC code is necessary. For hustle free payment transfer, share the accurate IFSC, branch name and account number with the transferer.
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Church of the Life-Giving Font of the Theotokos (Istanbul)
- This article is about the historic monastery. For the feast day see Life-Giving Spring.
In the fifth century, Holy Emperor Leo the Great oversaw the building of a church named in the honor of the Most Holy Theotokos. It was built in the Seven Towers district of Constantinople.
The present church, built in 1835, bears the same dedication as the shrine erected in this place between the end of the fifth and beginning of the sixth centuries, named for the wonderworking holy spring there. For almost fifteen hundred years, this sanctuary has been one of the most important pilgrimage sites of Greek Orthodoxy.[1]
The site was chosen by Leo due to a divine experience the emperor went through earlier in his life. Leo was walking in a forested area when he saw a blind man who asked him for water to quench his thirst. It was then that Leo heard a message from a voice saying that there was water deep within the woods that the man could drink. The clay from its waters would be able to heal the man's eyes. The Theotokos also prophesied at this time that Leo would one day become emperor of Constantinople. Leo listened to the voice, quenched the man's thirst, and allowed him to gain sight just as the Mother of God proclaimed.
This site was the place where Emperor Leo decided to build the church in her name. The blessed water continued to work miracles for others and earned the name "The Life-Giving Spring."
Vicissitudes of the Church
In its history, the fountain had been destroyed and then rebuilt on many occasions, at the request of the Virgin Mother.
Ottoman era
After serving the Christian people at Constantinople for about 1,000 years, Muslim invaders tore down the church in 1453 after taking over the city of Constantinople. The Church of the Life-giving Spring was destroyed and its building materials were used to construct the Bayezid II Mosque for the Sultan. The church site was covered with earth and crushed stone, so that the very foundations of the church disappeared from sight. The beautiful surrounding areas were turned into a Muslim cemetery. A Turkish sentinel, placed at the ruins of the church, forbade Christians not only to gather at the site, but even to approach there.
Little by little, the strictness of this ban eased, and Christians were permitted to build a small church there. Twenty-five steps led down into the chapel, which had a window in the roof to let the light in. The holy Spring was still there, surrounded by a railing.
However after the onset of Greek War of Independence in 1821, even this little chapel was destroyed, and the Spring was buried under the rubble.
A decade later, a group of Christians received permission to excavate the fallen church to rediscover the blessed waters. Even upon these shards of the former magnificent holy structure, the Theotokos, as before, granted hearings through her grace. Later, among the broken pieces in one of the windows was found, already half-rotted away through time and dampness, a panel on which were recorded ten miracles which occurred at the Life-giving Spring during the period 1824-1829.
During the reign of Sultan Mahmoud II, the Orthodox received a measure of freedom to conduct religious services. They used it to erect, for the third time, a large and prestigious church above the sacred Life-giving Spring, with work beginning in July of 1833. While workmen were clearing the ground, they uncovered the foundations of the earlier church. The Sultan allowed them to build not just a chapel, but a new and beautiful church on the foundations of the old one. Construction began on September 14, 1833, and was completed on December 30, 1834.
On February 2, 1835, with great pomp, the Ecumenical Patriarch Constantius II of Constantinople, celebrating with 20 bishops and an enormous flood of the faithful, consecrated the church which stands to this day, dedicating it to the Most Holy Theotokos.
Nearby was built a hospital and alms-house. Even the Muslims spoke with great respect of the Life-giving Spring, and of the Theotokos, who through it pours out her grace-filled power. "Great among women Holy Mary" is how they refer to the Most Holy Virgin. The water from the Life-giving Spring they call the "water of Holy Mary."
Modern era
On September 6, 1955, the church was destroyed again during the Istanbul Pogrom. Another small chapel has been rebuilt on the site, but the church has not yet been restored to its former size. The spring still flows to this day and is considered by the faithful to have wonderworking properties.
List of Churches and Monasteries
The Life-Giving Spring gave origin to many churches and monasteries bearing the same name in the Greek world. Most of them were erected after the end of the Byzantine Empire.
- Original monastery in Constantinople.
- Monastery of the Theotokos the Life-Giving Spring -- Dunlap, California.
- Monastery of the Life-Giving Spring -- Kastri, Pellana municipality, Laconia prefecture, Greece.[note 1]
- The Life-Giving Spring Acadimias, Athens
- Theotokos of the Life-Giving Spring Russian Orthodox Mission -- Bryan, Texas
See also
- ↑ Raymond Janin (in French). La Géographie ecclésiastique de l'Empire byzantin. 1. Part: Le Siège de Constantinople et le Patriarcat Oecuménique. 3rd Vol.: Les Églises et les Monastères. Paris: Institut Français d'Etudes Byzantines. 1953. p.232-37.
- ↑ In Greek: ΙΕΡΑ ΜΟΝΗ ΖΩΟΔΟΧΟΥ ΠΗΓΗΣ, Καστρί, Καστόρειο, 23059, ΛΑΚΩΝΙΑΣ, 2731057238.


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Let D ⊂ ℂ be the closed unit disc in the complex plane, and let C be a continuously embedded path in D between the points -1 and 1. The curve C splits D into two halfs $D_1$ and $D_2$.
Let f : D→ℂ be a continuous function that is holomorphic on the interiors of $D_1$ and $D_2$.
Is f then necessarily holomorphic?
PS: If he path C is sufficiently smooth (so that ∫C f(z) dz makes sense), then f is necessarily holomorphic, as it is then given by Cauchy's formula $f(w)=1/(2\pi i)\int _ {\partial D} f(z) /(z-w) dz$.


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The weeks leading up to Christmas were beyond overwhelming for me this year due to health & other issues, so much so that when getting exchanges & gifts ready to mail I totally forgot ... with the exception of one package ... to take photos of any extras I might have sent in addition to stitched items! Here are the photos I did take of the ornaments I sent (& some of these photos had to be borrowed because I forgot to take them as well!) ... all stitched for exchanges & gifts, all stitched in 2014. If one exists, I will provide a link to recipients' blog posts so you can see additional items sent.
For Kaye - Kitten Stitching
For Marie - Creative Thread
For Trace - Granny Trace Scraps & Squares
For Lisa - The Inspired Stitcher
For Kevin - Cabbages & Kings
This Santa was for Kevin too : )
For Edgar - Blacksheep's bit of the Web
(Edgar's photo)
For Maggee - Stitching Devotee
For Annette - California Stitcher
This winter scene was for Annette too : )
For Sarah - Sarah in Stitches
For Michelle - Michelle's StitchCraft Place
Participation in exhange group organized by Angela P
(Michelle's photo)
For Carol - Stitching Dreams
For Sally - Stitchyangel's Treasures
Click here to see Sally's post of other items received
Click here to see Sally's post of other items received
For Anne - Doll's Musings
For Kim - Wisdom with Needle & Thread
For Cathy - Orange Sink
For Jen - The Country Mouse
For Vicki - Simply Victoria
For Marly - Samplers & Santas
For Justine - Justine's Cross Stitch
For Gaynor - Stitcher's Anon
For Sharon - Shebafudge
For Mary - no blog
For Jo - Serendipitous Stitching
Three of these cardinal ornaments were given
#1 - For Myra - Gr8dame's Place
#2 - For Pam - My Stitchin-n-Stuff
#3 - For Elena - BusyHandsCraft ... my craft blog
For Angela - Hooked on Stitches
For Robin in VA - no blog
For Patricia - no blog
(Patricia's photo)
Finish idea by Carol - Stitching Dreams
For Lynda Ruth - Purple Pixie Dust
(Lynda Ruth's photo)
Two of these bobbin lace snowflakes were given
#1 - For June - Butterfly wings
#2 - For Michelle - Michelle's StitchCraft Place
For Vickie - A Stitcher's Story
Pink scarf knitted by Angela P's mother
(Vickie's photo)


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Published at Monday, April 29th, 2019 - 04:27:22 AM. Curtains. By Lacina Fabre.
Measuring for made to measure curtains:
Majority of the manufacturers use FR nylon mesh fabric for the top portion with a snag-free, woven header, along with a grommet for providing support and ensuring durability. The bottom portion would generally be stitched with polyester yarn that possesses 100% fire retardant capacity for absolute flame resistance. The fabrics are classified as antibacterial materials, antimicrobial materials, botanical materials, bio-active materials, and eco-friendly materials. Such materials are normally used for cubicle curtains supplied to hospitals. Shower curtains would be made of normal polyester yarn fabrics, because the other types of fabrics would be too costly to warrant using them in home.
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Divided into East and West by virtue of being on both the ocean side and river side of A1A, the securely gated South Beach community of Ocean Oaks in Vero Beach offers great value and location. When you decide to purchase one of the luxury Ocean Oaks homes for sale, you are making a great choice for your lifestyle and your future. Ocean Oaks homes have continued to appreciate in value, even during the recent economic downturns.
Ocean Oaks is an intimate gated, family-friendly community of newer estates centered on a lake, with private deeded beach access across the street.
The South Beach area of Vero Beach's barrier island continues to be one of Vero Beach's most sought after areas; partly due to the great Vero Beach location near to State and local parks & beaches. Ocean Oaks is only a short ten minute drive from the city which offers numerous shopping & dining venues, as well as historic and cultural opportunities.
The Ocean Oaks community surrounds a small lake which has become the centerpiece of this community. The lush, tropical landscape of Ocean Oaks provides a peaceful atmosphere where you can enjoy the tranquility as you relax in a true tropical paradise while admiring the various tropical birds attracted by the same peacefulness.


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You're in the right place! Play best games for PC!
Top PC Games of All Time. The PC has always been on the cutting edge of gaming, being the place where new ideas tend to arrive first. It is the de-facto platform for MMOs, indies, F2P and MOBAs, all of which are huge deals right now. Traditionally the PC has also been the place where genres like strategy and sims thrive, mainly due to the tried and trusted mouse & keyboard controls. If you ask people what their favourite PC game of all time is, you're unlikely to get any sort of consensus. It's been around for a very long time. But this games made our list.


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It took this crew the short span of two weeks to "fly the house" in this National Geographic project to create a real life version of the house in Pixar's Up— lifted into the sky by balloons. "The real Up! Scientists recreate floating house from Pixar movie… and prove it really CAN fly" at dailymail:
The team from National Geographic have built a house inspired by the Pixar movie Up! that can really fly.
Using 300 helium-filled weather balloons, a team of scientists, engineers, two balloon pilots and dozens of volunteers, they managed to get the small house 10,000 feet into the air.
Of course it was not a real house, but a custom-built light weight one.
Executive producer Ben Bowie said: 'We found that it is actually close to impossible to fly a real house.'
Producer Ian White added: 'But what we can do is kind of fly a light-weight house and fly it safely with people on board.'
[via designboom]


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Karan Johar, famous Bollywood director and producer, is currently producing a Bollywood movie, directed by Tarun Mansukhani. Karan has said that the movie would focus on the significance of voting. That means, this movie would make people realize the importance of his vote and would inspire the general people to cast their vote in election. You know that the general election of
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