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What's a Technology Sketch™
As part of our product development process, ThingM creates Technology Sketches, which are examples of early stage conceptual approaches to how a product might work, rather than actual fully-functional systems. We believe in lightweight, agile, user-centered product development, which means that we focus on users' experiences first and technological details later.
We prefer to explore ideas first without the constraints of technological limitations, before we create technologies to address those limitations. Our Technology Sketches document that process, the kinds of ideas we have, and how we develop them. We are continuing to develop the ideas and technologies at the core of these sketches. The final products that use those ideas may not resemble what is in the sketch, but the sketch will have been an important part of the development process, and one we share because we feel that others may benefit from it.


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Blame China, not the U.S., for the Plight of Chen Guangcheng
By Nicholas Burns
The dramatic events in Beijing surrounding the brave Chinese dissident, Chen Guangcheng, are confounding and hard to fathom at such a great distance and without all the facts. That has not stopped critics who should know better from rushing to blame the Obama Administration for having mishandled negotiations with the Chinese authorities over his fate.
It is irresponsible to second-guess Washington when we don't know the full story. Instead, the true culprit in this fascinating and increasingly tragic drama is the usual suspect–China's authoritarian government. China has hounded and mistreated Chen and his family for years. Beijing is now trying to intimidate him when he is beyond the protection of the American embassy. None of this is surprising given China's lamentable human rights record and its shameful status as the world's greatest human rights abuser. It was also standard Chinese practice to demand a U.S. apology for harboring Chen, an apology that will surely not be forthcoming.
The State Department did many things right during this tumultuous past week. It was right to permit Chen to stay within the walls of the American embassy for six days. It was right to keep negotiations with China private and beyond the glare of the press as that maximized the chance of an agreement to protect Chen. And, I have no doubt that Secretary Hillary Clinton and Ambassador Gary Locke, both long-time champions of human rights, did everything in their power to protect him.
Now that Chen has made a series of increasingly anxious statements from his hospital bed, some quite critical of his American protectors, the U.S. would be well advised to bring his fate back to the center of the talks in Beijing this week. Secretary Clinton has every right to remind the Chinese government about the commitments they made to permit Chen to rejoin his family and live a life free of intimidation and for continued American government access to him. Given the confusion surrounding Chen's decision to leave the embassy, this will also make it clear where the U.S. stands —on Chen's side against China's cynical leaders.
There is no question that the relationship with China is now our most important worldwide. There are plenty of vital issues—Iran, North Korea, Syria, the global economy—for the two governments to discuss. And, we often need to balance our concern for human rights in favor of progress in the security and political realm. This is not one of those times. In the end, what separates our country and China is the huge ideological gulf between us on the core issue of human freedom. Chen's case has become so important symbolically that we simply cannot afford to "balance" it with any other issue this week. We need to stand up to China to defend Chen's right to live a normal and peaceful life.
One thing is certain. No matter how this drama ends, it has exposed for all the world to see China's achilles heel as an emerging superpower. Its denial of basic rights and the brutal repression of its people will discredit the communist regime in every corner of the world and may very well be its ultimate undoing. The U.S. remains the single greatest power not just because we have a stronger military than China but due to our core belief in what the nineteenth century Boston abolitionist Theodore Parker described so powerfully– "I do not pretend to understand the moral universe; the arc is a long one…..I am sure it bends toward justice."


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Helm Crag Walk
Helm Crag, near Grasmere
Grade: 3 Approximate length: 8 Miles
Despite Helm Crag Walk being of low height (approx 1,328ft) it sits prominently at the end of a ridge, easily seen from the village of Grasmere. This combined with the distinctive summit rocks at the south east end of the summit ridge, which provide the alternative name, 'The Lion and the Lamb' makes it one of the most recognised hills in the area, with the term Helm meaning 'cloud capped hill'.
Alfred Wainwright wrote of Helms Crag walk that "The virtues of Helm Crag have not been lauded enough. It gives an exhilarating little climb, a brief essay in real mountaineering, and, in a region where all is beautiful, it makes a notable contribution to the charms and attractions of Grasmere".
This is the only Wainwright that the man himself never summited due to the tricky nature of this final rocky climb.
Helm Crag walk offers a varied array of Lakeland scenery, with wooded glades, spring blue bells, rocky out crops and open fells covered with ferns dependent on time of year.
Starting from Easedale Road within the village of Grasmere, follow the road whilst crossing over Easedale Beck. Pass the road sign posted Youth Hostel on your right and continue upon the road until the road turns sharply to the right.
Helm Crag Walk
I should point out that at this point there are 2 possible routes you may take, whilst this particular walk will follow the Lancrigg route as opposed to the Far Easdale and Helm Crag walk footpath.
Having rounded the sharp bend coming into view you should see a footbridge on your left which would take you to Easdale Tarn. Continue on the road keeping to your right until the road divides, taking the Lancrigg road, where it is possible to enjoy refreshments, such as teas, coffees and light lunches at Lancrigg Vegetarian Country House Hotel.
Taking the track to the front of the house you will pass through 2 gates and into a wooded area where the path is clearly marked. Keeping to the path follow this as it meanders through the wood and gently climbs upwards and through the woods. The track will traverse the farm fields with a dry stone wall to your left, whilst you walk upon level ground before passing through a gate.
The height of Helm Crag walk will now become apparent as it rises to your right, with a steep climb to come. You will arrive at what I can only explain with similarities to a stone staircase, although this staircase rises considerable higher and when wet can be slippery. On reaching the top turn left following the track which is clearly visible and this will take you to the summit.
On reaching the summit this is an ideal stop for refreshments, although it can be windy and you will be rewarded with stunning views of Grasmere below and the main road between Keswick and Grasmere but a threaded black line in the valley bottom.
Helm Crag Walk
Follow the ridge from Helm Crag walk as it gently swings around to descend towards Far Easdale where you simply follow the track downwards, although in places it is not so visible. Having descended you will join the footpath from Far Easdale and turning left follow this footpath down Far Easedale Gill which will bring you back to Easedale House and the road back to Grasmere.
It is possible when you join Far Easdale Gill footpath to turn right and continue over to Easdale Tarn should you desire to extend your walk, weather and time permitting.
Please note that our walk description of Great How, like any outdoor activity can be extremely dangerous and can result in permanent disability or even loss of life. Participants should be aware and except these risks whilst being responsible for their own safety. Always seek advice and information before embarking on any outdoor activity.
Should you wish to see better quality photographs of this Helm Crag walk please visit Helm Crag on our Lake District Walks Flickr account.
Please feel free to comment below on Helm Crag walk, share or even hit the Face Book like button.
I trust you enjoyed Helm Crag walk and found it helpful.


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SEATTLE (Reuters) - A landslide thundered through a subdivision in Washington state's Whidbey Island north of Seattle on Wednesday, destroying one home and threatening more than 30 others, a fire official said.
"It looks like a giant shovel pulled the hill down to the water," said Central Whidbey Fire Chief Ed Hartin. "We heard a lot of rumbling and snapping of trees."
The landslide hit the Ledgewood Beach community about 50 miles north of Seattle at 4:15 a.m. local time, knocking one house off its foundation and destroying a road, Hartin said.
Authorities rescued 12 residents from nearly 20 homes in the area that were cut off when a road was damaged by the landslide, Hartin said.
Another 17 homes were evacuated because they were left unsafe or uninhabitable by the disaster, he said. None one was injured, he added.
The homes in the Ledgewood Beach area are a mix of year-round and vacation properties that sit high on a bluff overlooking the waters of the Puget Sound.
A local home owned by Microsoft Corp Chief Executive Steve Ballmer did not appear to be immediately threatened, Hartin said.
A county geotechnical engineer was evaluating how long residents would be forced to stay out of their homes.
"This is an area that has experienced a few landslides in the past," Hartin said.
The area has not experienced recent heavy rains, he said.
Reporting by Laura L. Myers, Editing by Alex Dobuzinskis and Richard Chang


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Welcome to our next class! We're creating an intimate setting for a concentrated study of the figure. This is not offered at most other workshops around LA. One of the special features of this drawing group is that we are going for 5-12 hour poses over multiple weeks.
This class will be a the second pose in a two-week session with Lynette.
Drop-Ins Welcome. Entry is $15.
We have tables, benches, chairs, and two easels.
Please call 818-390-2215 with any questions.


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Clinton's answer to has-been charge
Republicans in search of an attack line against Hillary Clinton have begun to cast her as a tired relic of the past — an implicit contrast to their own bench of up-and-comers like hip hop-listening Marco Rubio and libertarian-leaning Rand Paul.
But Democrats are confident that giving voters the chance to make history by electing the first female president — by definition a forward-looking act — would trump any argument that Clinton is too 20th century and give her a "change" mantra of her own.
Story Continued Below
"If Secretary Clinton runs, she'll be the nominee — the first female nominee of either party," said Stephanie Cutter, a former top adviser to the Obama White House and campaign. "That breaks through the 'old' tagline that the Republican geniuses are cooking up because, if handled correctly, women of all ages will absolutely be inspired by that. I don't recommend that be the totality of her message or platform, but there's no way to hide that fact and it certainly shouldn't be discounted. "
( PHOTOS: Hillary Clinton's world tour, 2009-2012)
It's the type of "first" campaign that was a hallmark of the Barack Obama 2008 effort, even if he didn't overtly run that way. Clinton ran a campaign that was focused primarily on experience and strength in 2008, after the pollster for her poll-driven campaign found that her gender could hurt more than help.
There's no question that one of Clinton's challenges in 2016 would be demonstrating that her candidacy is about the future and not a bygone era. Her husband ran two decades ago at age 46 as a turn-the-page change agent — famously using Fleetwood Mac's "Don't Stop (Thinking About Tomorrow)" as his campaign theme song against 68-year-old George H.W. Bush, in case the generational contrast wasn't obvious already.
Early attempts by a handful of Republicans to portray Clinton as a figure of the past are not solely about underscoring her age — she will be 69 on Election Day 2016 — but the fact that national elections are always framed as choices between moving forward or looking back.
( PHOTOS: Hillary Clinton's life, career)
In the 2008 Democratic primary, Obama didn't directly attack Clinton as a candidate of the past. But the contrast in that race was unmistakable, too: He was the 40-something upstart with the potential to make history, she the product of Washington and triangulation whose vote to authorize the Iraq War put her a little too close to George W. Bush. In an election cycle centered on change, primary voters demonstrated "Clinton fatigue" and went with Obama.
Yet this time, with a different political environment and, most likely, the absence of an Obama-like figure to contend with in a primary, Democrats believe that Clinton's potential to become the country's first female to win the White House would galvanize voters of all ages.
Jeremy Bird, who led the Obama campaign's field organization said that the idea of a Madam President would be "inspiring to a lot of people."
( PHOTOS: Who's talking about Hillary 2016?)
"The energy that would come if she decides to do that would be cross-generational, and cross-gender," Bird said.
In her last presidential run, Clinton generally avoided talking explicitly about her gender — save for her reference to "18 million cracks in the glass ceiling" in her June 2008 concession speech.


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Move over, sleepwalking: Your sexier, more sinister cousin is taking over your turf. Sleep-texting—or texting people while you're in a sweet, sweet slumber—is apparently a growing problem, probably because we now spend more time with our smart phones than we do with other people.
There are no cold hard facts, but it's creeping into our consciousness via social media. A quick search on Twitter shows that the problem doesn't discriminate—it affects everyone from teen girls to grown men.
"There are texts sent from my phone at 5am that I do not recall sending," one tweeter wrote. "I should stop sleeping next to my phone," added another.
This is absolutely my worst nightmare. I actually hide my phone at night to ensure that I don't sleep-sext my ex or some random my deepest, darkest secrets in the wee hours of the morning. It probably has a lot to do with my need for control. I'm very careful with what I tell people, so I have this feeling that my subconscious is about to rebel at any minute and unleash some word vomit on the poor, unsuspecting masses.
Am I going overboard? Probably, but better that than sending 50 apologies the morning after a sleep-texting binge.
Tell us: Have you ever sleep-texted?
Want more from Meagan? Follow her on Twitter.


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The world didn't break out in earthquakes but Grímsvötn, a volcano in Iceland, exploded over the weekend. The volcano sent a plume of ash and smoke nearly 8 miles high. Um, that's so huge you can see it from space.
The pictures were captured with the Metreosat-9 satellite by the Cooperative Institute for Meteorological Satellite Studies. It's like a pimple popping on the Earth's face. There's also a GIF of the images here. [CIMSS via The Atlantic]


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Piper's Creek Watershed
The Piper's Creek watershed is the third largest watershed in Seattle covering approximately 2.5 square miles and draining a total of 1,835 acres into Puget Sound. The main stem channel is roughly two miles in length and is contained almost entirely within the boundaries of Carkeek Park. Piper's Creek contains a number of in-stream species including coho and chum salmon (hatchery origin), sea-run and resident cutthroat trout, rainbow trout, and four kinds of sculpin. The best time to see salmon is in November.
Explore the Piper's Creek watershed on your own or with your school or community group today. (See a list of recreational and volunteer opportunities below.) In addition to being a wonderful place to visit both for the excitement of the Greenwood business district and the calm of Carkeek Park, the wider watershed is home to a number of the City of Seattle's award-winning green stormwater infrastructure projects and residential-scale demonstrations such as the original SEA Streets, the Broadview Green Grid, and the Carkeek Park Environmental Learning Center around which are a rain garden, rain barrels, and more.
Watershed tour information
- Piper's Creek watershed and Green Stormwater Infrastructure Tours – Available free of charge to groups of 8 or larger. Please call (206) 684-5999 or email firstname.lastname@example.com to schedule.
- Urban Watershed Field Trips – Each fall, the City of Seattle's Protect Our Waters program sponsors 2-hour, naturalist-led field experiences at Carkeek Park and Camp Long to qualified K-5 teachers. Email email@example.com for details.
Want to learn more?
Piper's Creek is one of approximately 10,000 streams that flow into Puget Sound. Why is that important? Because you can help reduce the impacts of polluted runoff.
- Learn more about Piper's Creek from the City of Seattle's State of the Waters Report (pdf).
- Watch a 29-minute film - Lost and (Puget) Sound: How We Followed The Rain And Found Our Voice is designed for the classroom, but important for all Puget Sounders looking for an entertaining way to learn about the connection between one's local waterways and Puget Sound. An official selection of the Colorado Environmental Film Fest.
- Explore Piper's Creek's relationship to Puget Sound on the Puget Sound Starts Here website.
- Watch a YouTube video of a chum salmon swimming from pool to pool in Piper's Creek.
- Contact the Protect Our Waters staff based at Carkeek Park. (206) 684-599
- Stencil a storm drain.
- Get dirty. Take action. Connect with a community / volunteer group based at Carkeek Park in the Piper's Creek watershed.
- Friends of Piper Orchard – A volunteer group dedicated to the care of historic Piper Orchard in Carkeek Park.
- Carkeek Watershed Community Action Project – The Piper's Creek watershed's original advocacy group coordinates the Salmon Feeder and annual Salmon Count amongst many others. Call Nancy Malmgren at (206) 363-4116.
- Carkeek Streams, Trails, and Restoration Stewards (STARS) – Meet for restoration projects in Carkeek Park on the 3rd Saturday of every month. Email firstname.lastname@example.com or call (206) 362-2980.
- Weekday Workers – You can volunteer for restoration projects in Carkeek Park during the week. Email firstname.lastname@example.com or call (206) 782-7617.
- Friends of Llandover Woods – Forest restoration volunteers in Llandover Woods meet on the 2nd Sunday of each month.
- Carkeek Park Advisory Council – Steering committee for Carkeek Park meeting on the 4th Monday of each month. Email firstname.lastname@example.com or call (206) 684-0877.
- Annual Events – Earth Day (April), Salmon Celebration (day after Thanksgiving), Salmon watching (November-December), Mother's Day Walk (May), Greenwood Parade (July).


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Update; Haven't had time to get a new fuel filter yet; will post results once I do and get it installed.... Jeff
Update; Haven't had time to get a new fuel filter yet; will post results once I do and get it installed.... Jeff
ex: K75S Berlina R100GS/PD , K100RS , R75/5 , R60/2
I replaced my 3 year old fuel filter with a new one (Napa 3012 $5.39) today, put some Chevron unleaded in the tank and went for a ten-mile ride around town in the heat of the day.
Not a chirp or squeal to be heard so far; my fingers are crossed that Don was right on target with his diagnosis and that I'm good to go now.
If I am speaking too soon I'll be back to report further but for now I am a happy camper. Thanks Don!
ex: K75S Berlina R100GS/PD , K100RS , R75/5 , R60/2
Don is almost never wrong.
Paul Glaves - "Big Bend", Texas U.S.A
"The greatest challenge to any thinker is stating the problem in a way that will allow a solution." - Bertrand Russell
Don Eilenberger http://www.eilenberger.net
Spring Lk Heights NJ NJ Shore BMW Riders
'12 R1200R - I love this bike!
If you still have your old filter, you can test it to see how plugged it was by gently blowing through it in the direction of the arrow. If there is ANY resistance, it is dirty. If there is significant resistance, it's plugged up and definitely your problem.
Ride Safe, Ride Far, Ride Often
Lee Fulton Forum Moderator
3 Marakesh Red K75Ss
Mine, Hers, Spare
Thanks again, guys. Although I haven't ridden the bike again yet I really do have a hunch that the problem is solved.
I did blow through the filter afterwards but I think I might have been blowing the wrong way. There wasn't much resistance as I recall but it's only the second time I've ever dealt with a K bike filter thusly. Coincidentally, the same day I was blowing through the filter I had been blowing through some elaborate medical apparatus during a clinical research study of lifelong non-smokers I was participating in to determine my lung capacity!
So even if there was any resistance in the filter I might not have been able to notice it as I was blowing as hard as I could about a dozen times earlier that day.
I'll post a followup next time I go for a decent ride which may be later today; been moved in for a couple of months now and I've hardly begun to discover all the great roads around Albuquerque yet.
ex: K75S Berlina R100GS/PD , K100RS , R75/5 , R60/2
You have to blow VERY LIGHTLY.
Ride Safe, Ride Far, Ride Often
Lee Fulton Forum Moderator
3 Marakesh Red K75Ss
Mine, Hers, Spare
Just got back from a 136-mile ride that I made kinda on the spur of the moment. Left at 3:30pm local, got back about 3 hours and 20 minutes later. All two-lane.
For those of you familiar with New Mexico, my route was ABQ-Carnuel-Tijeras-Escobosa-Chilili-Estancia-Tajique-Torreon-Punta de Agua and my "destination" was Quarai Nat'l. Monument. Spent 10 minutes there to take another look at the ruins of the huge old church there (last visit was in 1979) and then I turned arouund and headed home.
It was a gorgeous puffy-white cloud New Mexico summer afternoon and the ride was PERFECT.
Not a whimper, screech or chirrrrrrrp was heard the whole time.
Wow, what a feeling!
ex: K75S Berlina R100GS/PD , K100RS , R75/5 , R60/2
No problems until my next longer ride on August 7th. Near the tail end of the 145-mile loop the chirp popped in a few times for a few seconds.
With a couple more rides around town about a week later the chirp was definitely back and as loud as ever. The last ride it was screeching and warbling like a police whistle (UK) and when I pulled onto the driveway I got off and got down next to the running engine. It was so loud I coudn't tell where it was coming from.
While I already went back to Napa and got another fuel filter to have on standby I am now wondering about another possible culprit that's making the noise.
I noticed that my headlight and aux. lights were dimming a bit at idle like when I was sitting at a stoplight at night; something I haven't noticed before at all. Could the alternator be making all the racket? Maybe the brushes are wearing out or? Another possible clue is the fact that when I went out to the garage to start the bike (was planning on another 125-mile RT to Santa Fe today)---the battery was too dead for the indicator lights to come on. Leads me to believe my alternator hasn't been charging much at all (I also did have a loose battery connection that I discovered and fixed on the 6th, though).
Sorry to be back here with the bad news so soon after what I thought was the fix (and may still be if there was some junk left in the tank after I replaced the fuel filter).
If anyone knows of such a thing as a chirping alternator on a K bike, do let me know. Meanwhile, the battery is being charged with my trickle charger for a good long stretch.
Otherwise, I'll go ahead and replace the filter again despite the very short time it's been installed. Could be another batch of bad gas, too---who knows?
ex: K75S Berlina R100GS/PD , K100RS , R75/5 , R60/2
The noise you describe arrived with smaller fuel pump fitted from 1993. It tends to occur with hot fuel and/or low fuel levels. A Service Bulletin from that era advised us to install a length of submersible fuel line to the return pipe in the tank and to direct the hose over the fuel pump.
Interesting news; I suppose the extra fuel pouring over the fuel pump would serve to cool and or quiet it down, right?
My best option might be just keep the tank filled up as I know that no K75 fuel pump likes a low level to begin with.
Now I am wondering if this is a telltale sign that my fuel pump is going to need replacing sometime soon. When I took it out to inspect it and replace the in-tank fuel lines/filter and pump sock three years ago the rubber surround was firm and intact---so I don't think it's any kind of goo issue---at least.
Anyone else care to weigh in on this? Perhaps my alternator issue (if it is also going faulty on me) is a coincidence in the first place. Oh, woe is me; almost all of the things my bike needs done (new fork seals, new front wheel bearings, valve adjustment, alternator(?) and fuel pump(?)) are either beyond my limited expertise, capacity or budget these days.
Thanks for the insight, Lost Boy, though; it helps.
Last edited by Zagando; 08-20-2012 at 04:21 PM. Reason: going blind typos
ex: K75S Berlina R100GS/PD , K100RS , R75/5 , R60/2
Those pumps were noisy even when the bikes were new. Hence the service bulletin. Installing the hose in the tank is not expensive or terribly difficult.
I still have some leftover in-tank fuel line from my partial renovation done three years ago. Where, exactly is that point that I would attach it to before positioning the other end over the fuel pump, please?
ex: K75S Berlina R100GS/PD , K100RS , R75/5 , R60/2
I'de like to see where this run of fuel hose goes too, as I have one of these newer style pumps in a very early K-100RS.
Experience is what you get when you don't get what you want.
I filled up the tank again today thinking that the fully submerged fuel pump might behave thus but that notion was quickly dispelled. Still as noisy as ever.
I think that idea of running a fuel line over to the pump is nonsense; yet I will be the first to apologize should/could I be proven wrong. No amount of fuel is going to cool it down enough to be quiet.
I suspect that my pump is beginning to die or wear out---nothing more or nothing less.
Hope that it's not a dangerous situation brewing as I ride around New Mexico in the 90+ degree heat and the pump (or something inside the tank, presumably) chirping like a canary on steroids. How do fuel pumps die?
Curious to hear any stories about other's going south and whether it is usually sudden or long and drawn out.
---Perplexed in ABQ
ex: K75S Berlina R100GS/PD , K100RS , R75/5 , R60/2


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Diazolidinyl Urea
Veterinarian Reviewed on January 9, 2012 by Paulina Nelega, RH
Posted in Uncategorized
Diazolidinyl Urea
Diazolidinyl urea is typically found in the form of a fine white powder that is used for its preservative properties largely in cosmetic products. It is a protection against yeast, bacteria, and molds that cause spoilage. It also acts as a formaldehyde releaser.
Diazolidinyl urea is produced by a chemical reaction to the process of heating and the addition of sodium hydroxide solution into allantoin and formaldehyde. The resulting reaction mixture is then neutralized with hydrochloric acid and then evaporated.
The commercialized diazolidinyl urea is a blending of various formaldehyde addition products, which include polymers.
History and Origin
Urea, the previously known compound that some chemists related to Diazolidinyl urea in terms of processes was first discovered by Hermann Boerhaave in the early part of the 18th century from evaporates of urine. Hilaire Rouelle in 1773 was able to obtain crystals containing urea from the urine of a dog through evaporating and treatment with alcohol in successive filtrations. When Antoine Francois, comte de Fourcroy and Louis Nicolas Vauquelin in 1799 discovered that the nitrated crystals were exactly the same to Rouelle's substances, they named the substance as urea.
Procedures in coming out with the purest substance evolved throughout the years until different combinations were obtained that had urea as the base ingredient for the process. Similarly, Diazolidnyl urea was also discovered through the process of chemical reactions from heating, evaporation and the with the addition to or combination of certain substances.
Although urea itself has had many uses for many decades, Diazolidnyl urea is mostly used as a preservative for personal care products and in beauty care products.
Ancient Uses
Since the process for producing Diazolidnyl urea was only discovered in the early 20th century, there was no known record that the actual substance was used by ancient people. However, there have always been a few myths that urine was used for medicinal purposes and as a fertilizer for some varieties of plants. Otherwise, there is not any specific evidence that Diazolidnyl urea was widely used by the ancient world.
Modern Uses
Diazolidinyl urea today is used primarily as a preservative in several applications such as in cosmetics and personal care products. Some of these products are: liquid soaps, cleansers, pet shampoos, lotions, creams, make-up removers, sunscreens, moisturizers, bubble baths, detergents, dishwashing liquids, cleaning agents, cosmetics, shampoos and conditioners, hair care products, as well as most skin care products.
Aside from being a good preservative in cosmetics, Diazolidnyl urea is also a very effective antimicrobial preservative. It is widely known as a formaldehyde releaser, but it is determined to be safe with certain amounts and in moderation.
Side Effects
It is possible that some people may develop a contact allergy to Diazolidinyl urea. The reaction may appear several days after the contact with symptoms that include swelling, redness, fluid-filled blisters, and itching. The scare about this product was brought about by its characteristic as a formaldehyde releaser, which is considered to be a possible carcinogen. However, numerous experiments and tests have proved that it is safe.
The Cosmetic Ingredient Review Expert Panel evaluated the scientific data of Diazolidinyl urea and it was decided that Diazolidinyl urea was safe as a cosmetic ingredient up to a maximum consistency of 0.5%. Today, numerous beauty and personal care products are using Diazolidinyl urea.
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Paulina Nelega, RH, has been in private practice as a Clinical Herbalist for over 15 years. She has developed and taught courses in herbal medicine, and her articles on health have appeared in numerous publications. She is very passionate about the healing power of nature. Ask Dr. Jan


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This Little Girl Isn't Having It: Boy Doesn't Want To Marry This Girl.. She Wants To Marry Him Hes Like NO. She's Like YESS! "When Your Azz Appears At My House, I Won't Say No"
"a boy doesnt want to marry a gal...but a gal forces him to marry"
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Curtron Products Products SPD-30-SS-GK-4884 Service-Pro® Series 30 Swinging Door
Curtron Products SPD-30-SS-GK-4884 Service-Pro® Series 30 Swinging Door
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DescriptionService-Pro® Series 30 Swinging Door, 48" x 84", 18 gauge stainless steel exterior and full perimeter gasket, 0.750" exterior grade wood core, 9" x 14" window
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How to boost productivity, reduce downtime, and save money: What you should know about motor maintenance programs.
A well-planned motor preventive maintenance (PM) program is the key to dependable, long-life operation of motors and generators. In modern plant operations, unscheduled downtime or long repair shutdowns are intolerable. These result in downtime costs that eat deeply into profits.
Most companies realize the need for good maintenance, but they sometimes resist investing in the proper tools, practices, or technical assistance that guarantee effective motor performance. So, it is important to justify a properly planned motor/generator preventive maintenance program.
Select the best approach. Organizing and setting a budget for a motor PM program is usually a difficult chore-you have much to consider. Take care not to practice the false economy of cutting costs in the wrong places. The program won't work if you don't have the proper test equipment, tools, and trained men. Consider what equipment you'll need and the time required to perform inspections, and keep accurate records. Determine which procedures are essential and who is best for the job.
Select the best motor-maintenance techniques for your type of equipment. For each type of motor or controller, a variety of maintenance methods are available. Choose the best methods and determine how to apply them. Consider whether you should check for possible bearing trouble on a motor simply by feeling the components for over-temperature and listening for unusual sounds, or by installing temperature-monitoring devices and making inspections using a stethoscope or an infrared scanner.
Motor maintenance. Lubricate regularly according to the manufacturer's instructions. On sleeve bearing and other oil-lubricated machines, check oil reservoirs regularly. In poor environments, change oil at least once a month. Never over-lubricate-excess grease or oil can get into windings and deteriorate insulation. Use only the lubricant specified for that machine. But with one exception. Advances in lubricants can make a switch to a newer lubricant worth while. Check with the manufacturer, first.
On essential motors, check bearings daily using a stethoscope, infrared scanner, or vibration analyzer. Check bearing surface temperatures with a thermometer, electronic temperature sensing devices, or stick-on temperature indicating labels. Compare temperature of hot bearings with the temperatures of normal operating bearings. Check oil rings, and watch for excessive endplay.
You should check the air gap between the rotor and stator with feeler gages at least annually. Measure at the top, bottom, and on both sides of the stator. Differences in readings obtained year-to-year indicate bearing wear.
Examine the belt tension. Belts should have about 1 in. of play. Seat the sheaves firmly with little to no play. Tighten couplings within tolerances to operate without excess noise. Check the alignment on all motor-generator sets and on motor-load couplings when trouble is suspected.
Inspect brushes and commutators of DC motors for excessive wear. Appropriate brushes are essential and should properly fit into the holders. Check spring pressure of the holders with a small scale. Adequate spring pressure ranges from 2 lbs. to 2 1/2 lbs. per sq in. of the brush cross-sectional area. Call the manufacturer or a service company to solve recurring problems of brush chatter, excessive brush wear, or sparking, streaking, or threading of the commutator.
It is also important to check the mounting of motors regularly. Inspect the mounting bolts, the steel base plates for warpage, and the concrete base for cracking or spalling. Because excessive vibration shortens motor life significantly, perform annual vibration analysis tests. You can perform field vibration analysis with portable instruments that display the vibration amplitudes and frequencies.
Keep the motor clean and cool. In high-temperature locations, consider using oversized motors. Excessive ambient temperatures will shorten motor life. Remove and disassemble important motors during summer or holiday shutdowns, allowing for a complete and thorough inspection, testing, and cleaning. Check the bearings, couplings and accessories. All of these steps will help you decide whether or not to recondition the motor.
Keep accurate records. Perform annual insulation-resistance tests and other appropriate tests. You should visually inspect motors thoroughly, then make voltage and current checks. Record and compare all values each year. The trends of the readings will indicate the condition of the motor and offer a guide to its reliability.
Motor controls. Keep control equipment clean. Blow out dirt weekly. Keep dust or contamination off of high-voltage equipment. This is important because dust may contain conductive materials, which could form unwanted circuit paths resulting in current leakage or short circuits.
Moving parts should operate without excessive friction. Check operations of contactors and relays by hand. Feel for any binding or sticking. Look for loose pins, bolts, or bearings.
Check contacts for pitting and signs of overheating, such as discoloration of metal and charred insulation. Contact pressure should be per the manufacturer's specifications. Watch for frayed flexible leads.
On essential controls, perform contact-resistance tests with a low-resistance ohmmeter regularly. A proper value of contact resistance is about 50 micro-ohms (50 millionths of 1 ohm). Don't forget to record the reading for future comparisons.
You should inspect overload relays thoroughly. Maintenance requirements for these relays include checking the rating or trip setting, taking into account ambient temperature as well as the higher inrush currents of modern, efficient motors. You should clean contacts, making them free from oxidation. To ensure reliable operation, test and calibrate relays every one to three years, using special equipment such as OL relay testers.
Maintaining equipment only during unscheduled downtimes is costly and often done too hurriedly. This information should help convince management to schedule preventive maintenance downtimes.
Show management how preventive maintenance pays dividends. Collect case histories of motor breakdowns and the cost of resulting lost production. Compare this to the lesser costof budgeted preventive maintenance.


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Published at Monday, March 12th, 2018 - 07:11:56 AM. Golf Club. By Vignette Beaule.
There is an entity known as the USGA or the United States Golf Association. This group determines the rules of golf, including the number of golf clubs that can be used in a round of golf. This limit is fourteen golf clubs. Normally, the standard golfer would have one driver, one putter, three wedges, seven irons, and two fairway woods in their golf bag. The combination of golf clubs is as varied as there are golfers. Hybrid golf clubs have begun replacing some of the longer golf irons and fairway woods in the golf bag.
However, I would like to give you a bit of insight into two companies which specialize in junior name brand golf clubs that I think are affordable and worth the money. You've probably never heard of them; nevertheless they are in the process of branding their own specialty kids' golf clubs.
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Samsung S8 Plus Case Love Pattern Gift For Girls Durable Metal Inforced Light Weight Samsung S8 Plus Cover Wrap Around 126
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When comics fans rattle off catalogues of great X-Men artists, there are a few names practically guaranteed to be on their lists. Jack Kirby, Neal Adams, John Byrne and Jim Lee are all givens. But me? I love Paul Smith. That's his stuff up there. To me, he's one of comics' greatest unsung comics talents. Who do you think deserves more love?
Taste in artistic styles is a subjective thing. While I think Paul Smith's clean-line minimalism is great, others may prefer a different look to their sequential storytelling. So, who do you think is a great under-appreciated comics artist? Share some artwork from your personal favourites below.


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Think you can't afford to study abroad? Think again! CEA scholarships, grants, payment plans, and financial aid support make finding funding easy. Don't let finances stand in the way of the adventure of a lifetime... Connect with our Student Accounts team today to learn about your options!
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Since 1997, CEA has maintained one simple philosophy: To provide high-quality international academic programs and services. That means support at each step of your experience, from the moment you apply to the day you return home. Along the way you'll learn to communicate across cultures. You'll earn credits while gaining valuable skills. And you'll discover more about yourself than you ever thought possible.
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Pazopanib Hydrochloride in Treating Patients With Advanced Thyroid Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00625846
Recruitment Status : Active, not recruiting
First Posted : February 28, 2008
Last Update Posted : November 15, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Recurrent Thyroid Gland Carcinoma Stage III Differentiated Thyroid Gland Carcinoma AJCC v7 Stage III Thyroid Gland Medullary Carcinoma AJCC v7 Stage IVA Differentiated Thyroid Gland Carcinoma AJCC v7 Stage IVA Thyroid Gland Anaplastic Carcinoma AJCC v7 Stage IVA Thyroid Gland Medullary Carcinoma AJCC v7 Stage IVB Differentiated Thyroid Gland Carcinoma AJCC v7 Stage IVB Thyroid Gland Anaplastic Carcinoma AJCC v7 Stage IVB Thyroid Gland Medullary Carcinoma AJCC v7 Stage IVC Differentiated Thyroid Gland Carcinoma AJCC v7 Stage IVC Thyroid Gland Anaplastic Carcinoma AJCC v7 Stage IVC Thyroid Gland Medullary Carcinoma AJCC v7 Thyroid Gland Anaplastic Carcinoma
|Other: Laboratory Biomarker Analysis Drug: Pazopanib Hydrochloride
|Phase 2
I. To establish the safety and efficacy of GW786034 (pazopanib hydrochloride) as a therapeutic in patients afflicted with differentiated, medullary and anaplastic thyroid cancers.
I. Assessment of the impact of therapy with GW786034 on serum/plasma vascular endothelial growth factor (VEGF) levels.
II. To explore the potential relationship between changes in thyroglobulin levels and tumor response in patients with advanced differentiated thyroid cancer known to be thyroglobulin antibody negative.
Patients receive pazopanib hydrochloride orally (PO) once daily (QD) on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 6 months for up to 3 years after registration.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|152 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Phase II Study of GW 786034 (Pazopanib) in Advanced Thyroid Cancer
|Actual Study Start Date :
|February 22, 2008
|Actual Primary Completion Date :
|December 21, 2018
Experimental: Treatment (pazopanib hydrochloride)
Patients receive pazopanib hydrochloride PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Pazopanib Hydrochloride
Given PO
Other Names:
- Proportion of patients who have achieved an objective response to the study agent [ Time Frame: Up to 3 years ]Objective response as assessed by Response Evaluation Criteria in Solid Tumors criteria.
- Confirmed tumor response (differentiated thyroid cancer expanded cohort) [ Time Frame: Up to 3 years ]Tumor response (complete or partial response) as assessed by Response Evaluation Criteria in Solid Tumors criteria noted as objective status on 2 consecutive evaluations at least 8 weeks apart for patients with differentiated thyroid cancer who are thyroglobulin antibody negative.
- Proportion of patients with differentiated thyroid cancer and medullary thyroid cancer who have not failed treatment at 6 months (3 months for anaplastic thyroid cancer) [ Time Frame: Up to 6 months ]The proportion of patients who have not failed treatment due to disease progression, adverse reactions, refusal for further participation, or who went on to alternate therapy at 6 months (3 months for anaplastic thyroid cancer patients) will be calculated and summarized independently within each of the patient groups. Assuming that the incidence of response is binomially distributed, 90% binomial confidence intervals will also be calculated.
- Proportion of patients in which the radioactive iodine scan have changed from "no uptake" to "any uptake" [ Time Frame: At 6 months (at 3 months for patients with anaplastic thyroid cancer) ]The proportion of patients will be calculated.
- Proportion of patients achieving a biochemical response in appropriate tumor markers [ Time Frame: Up to 3 years ]Levels of free VEGF and PDGF will be explored in a graphical manner in pre-treatment and multiple on-treatment samples.
- Incidence of toxicity [ Time Frame: Up to 3 years ]Toxicity will be assessed by the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0. The maximum grade for each type of toxicity will be recorded for each patient, and frequency tables will be reviewed to determine toxicity patterns.
- Overall survival [ Time Frame: Time from registration to date of last follow-up or death due to any cause, assessed up to 3 years ]Estimated using the method of Kaplan-Meier.
- Times to progression [ Time Frame: Time from registration to the date of progression or last follow-up, whichever comes first, assessed up to 3 years ]Time to progression will be estimated using the method of Kaplan-Meier. In addition, the 6-month progression-free rate will be evaluated using the 6-month rates and associated confidence intervals. Competing risk analyses may be done to evaluate time to progression, allowing for going on to alternate treatment or death prior to progression as competing risks.
- Time to treatment failure [ Time Frame: Time from registration to the date the patient discontinues treatment, assessed up to 3 years ]Estimated using the method of Kaplan-Meier.
- Time to subsequent therapy [ Time Frame: Up to 3 years ]Estimated using the method of Kaplan-Meier.
- Duration of response [ Time Frame: From the date of documentation of partial or complete response until the date of progression or last follow-up (whichever comes first) in the subset of patients with confirmed response, assessed up to 3 years ]Duration of response will be assessed.
- Biomarker-based response [ Time Frame: Up to 3 years ]Rates will be summarized assuming they are binomially distributed, and the biomarker levels themselves will be explored both quantitatively and graphically before and after treatment
- Change in blood markers for angiogenesis [ Time Frame: Baseline to up to 3 years ]Blood markers for angiogenesis including levels of free VEGF, free GW786034, and GW786034/VEGF complexes will be evaluated before and during therapy. Changes in these levels will largely be explored in a graphical manner as well as exploring any potential relationships between these levels and clinical outcome such as response or progression-free rate and toxicity incidence.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|19 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Histologically or cytologically confirmed differentiated, medullary or anaplastic thyroid cancer that is now advanced or metastatic; NOTE: patients with thyroid lymphomas or sarcomas are specifically excluded, as are patients with metastatic disease from other sites of origin to thyroid
- Patients with confirmed differentiated thyroid cancer to be enrolled in the expanded/additional differentiated thyroid cancer (DTC) cohort must be thyroglobulin antibody negative
- Zero, one or two prior therapeutic regimens (this includes cytotoxic plus non-cytotoxic therapeutic regimens)
- Absence of sensitivity to therapeutic radioiodine (differentiated only)
- Measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as > 20 mm with conventional techniques or as > 10 mm with spiral computed tomography (CT) scan; NOTE: disease that is measurable by physical examination only is not eligible
- Life expectancy > 3 months
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, or 2 (Karnofsky >= 60%)
- Leukocytes > 3,000/mcL obtained =< 7 days prior to registration
- Absolute neutrophil count > 1,500/mcL obtained =< 7 days prior to registration
- Platelets > 100,000/mcL obtained =< 7 days prior to registration
- Total bilirubin =< 1.5 X institutional upper limit of normal (ULN) obtained =< 7 days prior to registration (if there is reason to believe that the patient has Gilbert's syndrome, the bilirubin can be fractionated; if the fractionated bilirubin is consistent with Gilbert's syndrome and there is no other possible explanation for the elevated indirect bilirubin, the patient may be eligible for the study if and only if the direct bilirubin is =< 1.5 X institutional ULN)
- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) < 2.5 X institutional ULN obtained =< 7 days prior to registration
- Creatinine =< 1.5 X ULN obtained =< 7 days prior to registration
- Proteinuria =< + on urinalysis (may re-check) obtained =< 7 days prior to registration
- International normalized ratio (INR) =< 1.2 X the ULN obtained =< 7 days prior to registration
- Blood pressure (BP) < 140 mmHg (systolic) and < 90 mmHg (diastolic); initiation or adjustment of BP medication is permitted prior to registration provided that the average of three BP readings at a visit prior to registration is < 140/90 mmHg
Objective evidence of tumor progression in the 6 month period prior to GW786034 initiation as assessed by:
- Unequivocal progression of objectively measured disease on successive appropriate imaging (e.g. CT scan); in cases of uncertainty of tumor progression, the principal investigator of the study will be available to assist in decisions
- Women of child-bearing potential must have a negative serum pregnancy test =< 7 days prior to registration; NOTE: women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately; effective contraception is required for all fertile participants in the trial
- Ability to understand and the willingness to sign a written informed consent document
- Willingness to comply with the requirement of the study
- Willingness to donate blood for correlative marker studies; (only applicable to sites within the United States)
Exclusion Criteria:
Anaplastic, differentiated, medullary: a total of > 2 prior therapeutic regimens (this total includes cytotoxic plus non-cytotoxic regimens); Note: enrollment of anaplastic, differentiated, and medullary patients who have had zero, one or two prior therapeutic regimens (cytotoxic plus non-cytotoxic regimens) is allowed - provided therapy ceased > 21 days prior to registration;
- NOTE: the principal investigator of the study should be contacted in the event of uncertainty related patient eligibility based upon prior therapies
- Disease that is measurable by physical examination only
Any of the following:
- Radiotherapy =< 4 weeks prior to registration
- Major surgery =< 4 weeks prior to registration
- Radiotherapy to >= 25% of bone marrow
- Concurrent therapy with octreotide unless tumor progression on this therapy has been demonstrated
- Any other ongoing investigational agents
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to GW786034 (pazopanib) or other agents used in the study
- > +1 proteinuria (< 30 mg/dL) on two consecutive dipstick or other urine assessments taken at least 1 week apart; NOTE: (in cases where questions arise related to disparate proteinuria measurements, the study principal investigator [PI] should be consulted for assistance in determining patient study eligibility)
- Corrected QT interval (QTc) prolongation (defined as a QTc interval >= 480 msecs) or other significant electrocardiogram (ECG) abnormalities (e.g. frequent ventricular ectopy, evidence of ongoing myocardial ischemia); NOTE: the principal investigator of the study should be contacted in the event of uncertainty related patient eligibility based upon ECG changes
- Receiving cytochrome P450 (CYP) interactive concomitant medications; certain medications that act through the CYP450 system are specifically prohibited in patients receiving GW786034 (pazopanib) because in vitro data indicate that the agent has the potential to interact with the cytochrome P450 isoenzymes cytochrome P450, family 2, subfamily C, polypeptide 9 (CYP2C9) and cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4); certain other agents should be used with caution
- Any condition (e.g., gastrointestinal tract disease resulting in an inability to take oral medication or a requirement for IV alimentation, prior surgical procedures affecting absorption, or active peptic ulcer disease) that impairs their ability to swallow and retain GSK786034 (pazopanib)
Any of the following conditions:
- Serious or non-healing wound, ulcer, or bone fracture
- History of abdominal fistula, gastrointestinal perforation, active diverticulitis, intra-abdominal abscess or gastrointestinal tract bleeding =< 28 days of registration
- Any history of cerebrovascular accident (CVA) =< 6 months
- Current use of therapeutic warfarin; Note: low molecular weight heparin and prophylactic low-dose warfarin (INR < 1.2 X ULN) are permitted; prothrombin time (PT)/partial thromboplastin time (PTT) must meet the inclusion criteria
- History of myocardial infarction, cardiac arrhythmia, admission for unstable angina, cardiac angioplasty or stenting within the last 12 weeks
- History of venous thrombosis in last 12 weeks
- Class III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system; NOTE: a patient who has a history of class II heart failure and is asymptomatic on treatment may be considered eligible
- History of bleeding disorder, including patients afflicted with hemophilia, disseminated intravascular coagulation, or any other abnormality of coagulation potentially predisposing patients to bleeding
- Poorly controlled depression or anxiety disorder, or recent (=< 6 months) suicidal ideation
- Known active and/or untreated brain metastases and/or brain metastases requiring ongoing therapy (e.g. corticosteroids); NOTE: (because of the poor prognosis often associated with brain metastases and because of the potential risk of bleeding in active brain metastases associated with multi-targeted tyrosine kinase inhibitor therapy, patients with active and/or untreated brain metastases and/or those with brain metastases requiring ongoing therapy - e.g. corticosteroids - are excluded from trial enrollment; enrollment will, however, be permitted in cases of patients with longstanding treated and inactive brain metastases not requiring ongoing therapy, providing that stability of brain metastases has been demonstrated for a period of 3 months or greater as assessed by intracranial imaging - and providing that there is no indication of increased vascularity of the treated metastases by magnetic resonance imaging (MRI) imaging conducted =< 14 days prior to registration; when questions arise related to these criteria, the PI of the trial, Dr. Keith Bible, should be contacted for assistance on eligibility)
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection or psychiatric illness/social situations that would or might reasonably be expected to limit compliance with study requirements
- Pregnant women; NOTE: (breastfeeding should be discontinued if the mother is treated with GW786034/pazopanib)
- Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy; NOTE: (appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated)
- Receiving any medications or substances known to affect or with the potential to affect the activity or pharmacokinetics of GW786034 (pazopanib); NOTE: the eligibility of patients will be determined following review of their case by the principal investigator; efforts should be made to switch patients who are taking enzyme-inducing anticonvulsant agents to other medications
- Receiving any concomitant medications that are associated with a risk of QTc prolongation and/or Torsades de Pointes; NOTE: these medications should be discontinued or replaced with drugs that do not carry these risks, if possible
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00625846
|United States, Arizona
|Mayo Clinic in Arizona
|Scottsdale, Arizona, United States, 85259
|United States, Colorado
|University of Colorado Hospital
|Aurora, Colorado, United States, 80045
|United States, Florida
|Mayo Clinic in Florida
|Jacksonville, Florida, United States, 32224-9980
|United States, Iowa
|University of Iowa/Holden Comprehensive Cancer Center
|Iowa City, Iowa, United States, 52242
|United States, Maryland
|Johns Hopkins University/Sidney Kimmel Cancer Center
|Baltimore, Maryland, United States, 21287
|United States, Michigan
|Wayne State University/Karmanos Cancer Institute
|Detroit, Michigan, United States, 48201
|United States, Minnesota
|Fairview Ridges Hospital
|Burnsville, Minnesota, United States, 55337
|Fairview-Southdale Hospital
|Edina, Minnesota, United States, 55435
|Unity Hospital
|Fridley, Minnesota, United States, 55432
|Minnesota Oncology Hematology PA-Maplewood
|Maplewood, Minnesota, United States, 55109
|Abbott-Northwestern Hospital
|Minneapolis, Minnesota, United States, 55407
|Mayo Clinic
|Rochester, Minnesota, United States, 55905
|Park Nicollet Clinic - Saint Louis Park
|Saint Louis Park, Minnesota, United States, 55416
|United Hospital
|Saint Paul, Minnesota, United States, 55102
|United States, Missouri
|Washington University School of Medicine
|Saint Louis, Missouri, United States, 63110
|United States, Wisconsin
|University of Wisconsin Hospital and Clinics
|Madison, Wisconsin, United States, 53792
|Australia, Western Australia
|Sir Charles Gairdner Hospital
|Nedlands, Western Australia, Australia, 6009
|China, Hong Kong
|Chinese University of Hong Kong-Prince of Wales Hospital
|Shatin, Hong Kong, China
|National University Hospital Singapore
|Singapore, Singapore, 119074
|National Cancer Centre
|Singapore, Singapore, 169610
|Johns Hopkins Singapore
|Singapore, Singapore, 308433
|National Taiwan University Hospital
|Taipei, Taiwan, 100
|Principal Investigator:
|Keith C Bible
|Mayo Clinic
Documents provided by National Cancer Institute (NCI):
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT00625846 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
NCI-2009-00198 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
7627 ( Other Identifier: Mayo Clinic )
7627 ( Other Identifier: CTEP )
N01CM00099 ( U.S. NIH Grant/Contract )
N01CM62205 ( U.S. NIH Grant/Contract )
P30CA015083 ( U.S. NIH Grant/Contract )
|First Posted:
|February 28, 2008 Key Record Dates
|Last Update Posted:
|November 15, 2019
|Last Verified:
|November 2019
Carcinoma, Medullary
Carcinoma, Neuroendocrine
Neoplasms, Ductal, Lobular, and Medullary
Thyroid Neoplasms
Thyroid Diseases
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Endocrine System Diseases
Endocrine Gland Neoplasms
Neoplasms by Site
Head and Neck Neoplasms
Neuroendocrine Tumors
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms, Nerve Tissue


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Anti obama yes he did demotivational poster in the demotivational category. Collection of interesting demotivators with humor and life demotivational pictures. You can view and download a large number of the best selected photos and images from around the web in comfort. Especially for you we have divided all the pictures by the most popular categories, so you can easily find the photos you need and pictures.
Anti obama yes he did demotivational poster
Views: 432Date: 6 NovemberSource: rlv.zcache.co.ukOpen in full sizeDownload


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June 29, 2007 - TPMKit
by Darington Forbes
Until early this week, security experts Nitin and Vipin Kumar of NV Labs were scheduled to present a briefing entitled "TPMkit: Breaking the Legend of Trusted Computing (TC [TPM]) and Vista (BitLocker)" This talk was removed from the schedule at the request of the presenters. The topic generated quite a great deal of interest and its removal from the schedule without comment has generated some confusion and controversy.
According to Tim Greene at Network World, the brothers said in an email comment, "We have pulled back our presentation from...Black Hat. So, we won't be presenting anything related to TPM/BitLocker in Black Hat...We would not like to say anything about the TPM/BitLocker for the time being." They have so far declined further comments in the media.
Black Hat did not pull the talk under external pressure. The decision to not present was made wholly by the Kumars and Black Hat was informed by the Kumars that they would not be presenting. If Black Hat receives further information on the decision, we will share it here.
Black Hat is a strong proponent of disclosure in the security space. The conference opposes the pressure to censor controversial talk content and strongly encourages its speakers and trainers to do the same.
At Black Hat Europe 2007, the Kumars presented a briefing called "Vboot Kit: Compromising Windows Vista Security." The paper they submitted can be found on the Black Hat Europe 2007 Media Archive.
A lot of work has been done in the areas of reverse-engineering, exploitation and code review of applications written in C. However, a majority of application development is done in C++ and has been for many years. Over the past five years a few researchers have looked at C++ specific issues, like Halvar Flake, but there has not been a lot of focus on security-related aspects of C++ in the public arena. ...read more
It is that time again: Black Hat in the hot LV summer. It always comes sooner than I expect. We have been working like mad to get the schedule together, which is basically done. One of the underlying themes this year is timing. I don't pick these things; it is really a reflection of the direction of research in our community. Another theme is nuance... read more
The Black Page is always looking for concise and interesting comments from researchers and experts about issues that affect the security community. Contact us here to learn more about submission rules


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Ask Eartha: If not properly trashed, toxic batteries keep going and going
Dear Eartha,
How toxic are household batteries? I do my best to recycle batteries, but is it OK if occasionally I throw one in the trash?
Chip, Dillon
Great timing on your question, Chip. Mr. Steward just asked me the same thing, so I'd love to clear the air on this issue. First of all, alkaline batteries have certainly gotten less toxic through the years. Back in the day, these batteries contained small amounts of mercury. Now they contain zinc, manganese oxide and potassium hydroxide instead.
Potassium hydroxide, the nasty stuff you find if you leave your batteries in your flashlight for a few years, tends to leak out of alkaline batteries. While potassium hydroxide may cause respiratory and skin irritation, it's not incredibly toxic.
That being said, there's no reason to add metals to our landfill and risk contaminating local water sources. The real issues with toxicity in batteries are all of the non-alkaline batteries out there. Since most of us have better things to do than read battery labels, it's definitely best to recycle all batteries.
Most of the other batteries around your house are probably of the rechargeable variety – NiMH (nickel metal hydride), Li-Ion (lithium ion) or NiCad (nickel cadmium). Rechargeable batteries can be replenished hundreds to thousands of times; unfortunately, they are more prone to leaking than alkaline batteries.
Nickel metal hydride batteries are nontoxic to humans, though nickel is toxic to plants. Lithium ion batteries are also nontoxic. Nickel cadmium batteries are a different story. Cadmium is highly toxic to humans, animals and plants and is found in both batteries and many electronic devices. In fact, cadmium is banned by the European Union's Restriction on Hazardous Substances. When contained in a battery or electronic device, cadmium is safe, but it's critical that cadmium not end up in our landfills.
Finally, car and marine batteries are lead-acid batteries, which are obviously critical to recycle since they contain lead. In fact, Colorado law requires that these batteries be recycled. If your battery is replaced by an auto shop, then you can count on them to recycle it for you.
Fortunately, battery recycling in Summit County could not be any easier. Simply collect all of your household and car batteries and take them to the Frisco or Breckenridge recycling center. Rest assured that your batteries will be properly recycled, keeping all of the toxic compounds out of Lake Dillon.
Wondering what happens to your batteries once you drop them off? Batteries are typically shredded and separated into their various components, so that the raw materials can be reused. Examples of products made from recycled batteries include new batteries, stainless steel and rebar.
We know that recycling batteries and electronics can be confusing, so feel free to contact me at eartha@highcountry
conservation.org or (970) 668-5703 with any questions.
Ask Eartha Steward is written by the staff at the High Country Conservation Center, a nonprofit organization dedicated to waste reduction and resource conservation. Submit questions to Eartha at firstname.lastname@example.com.
Start a dialogue, stay on topic and be civil.
If you don't follow the rules, your comment may be deleted.


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Recent News
July 14, 2014
California Firm Recalls Chicken Products Due to Possible Salmonella Heidelberg Contamination
EDITOR'S NOTE: This release was updated July 12 to further clarify and correct "Use or Freeze by" and "Best by" date ranges, as well as to provide an updated product list. The product list remains the same and the recall is not expanded.
The Missouri Department of Health and Senior Services received information regarding a recall of Foster Farms chicken products that may be contaminated with a particular strain of Salmonella Heidelberg.
The recalled product includes fresh and frozen chicken products sold by retailers under Foster Farms or private label brand names, with varying "use or freeze by" dates ranging from March 16 through March 31, 2014 and Aug. 29, 2015 through Sept. 2, 2015, and frozen Sunland Chicken products with "best by" dates from March 7 through March 11, 2015 and Aug. 29, 2015 through Sept. 2, 2015.
Consumers will only be able to locate such dates on fresh product retail packaging. [Other dates can be found on bulk master cases of products.] The products subject to recall bear the establishment number "P6137," P6137A" or "P7632" inside the USDA mark of inspection.
The chicken products were produced from March 7 through March 13, 2014. These products were shipped to Costco, Foodmaxx, Kroger, Safeway and other retail stores and distribution centers in Alaska, Arizona, California, Hawaii, Idaho, Kansas, Nevada, Oklahoma, Oregon, Utah and Washington.
The full recall can be found at www.fsis.usda.gov/wps/portal/fsis/topics/recalls-and-public-health-alerts/recall-case-archive/archive/2014/recall-044-2014-release.


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PASADENA — Hearing the media drumbeat grow louder and louder, Oprah Winfrey has decided to stretch her Lance Armstrong interview from one night to two.
So clear your calendar for Thursday at 9 p.m. EST (as originally announced) — and now also Friday at 9 — for "Oprah and Lance Armstrong: The Worldwide Exclusive" on OWN network.
In Tuesday's special-inflation announcement, OWN promised that the cyclist would address the "alleged doping scandal" that has plagued his career.
Armstrong is going to come clean to Oprah but not go into great detail about specific cases and events, according to USA Today. Two nights is a lot of time to fill to not go into detail about specific cases and events.
Over the years, Oprah has carved out a niche as the first Station of the Cross on the Road to Redemption for celebrities.
Most recently, David Letterman discussed his office affairs with Oprah — a.k.a. the Queen of the Confessional — to clean up his reputation as he was being honored by the Kennedy Center.
And in 2010, Jay Leno made his pilgrimage to Oprah before returning as host of "The Tonight Show" in March of that year. Leno sought absolution after being blamed for Conan O'Brien's resignation from the iconic NBC late-night show. Leno admitted to Oprah that he'd "told a little white lie" when he announced on the air in 2004 that he would "retire" after Conan took over "Tonight" in '09.
Armstrong's sit-down with Oprah is the only interview that the seven-time Tour de France winner has given since he was stripped of his titles and dropped from endorsement deals worth millions of dollars. That happened last year after the U.S. Anti-Doping Agency released an extensive report accusing the cyclist of doping throughout his career.
Armstrong received a lifetime ban on competing professionally.
Oprah told the gang on BFF Gayle King's show, "CBS This Morning," that she added the second night because her interview with Armstrong went on for 2 1/2 hours. The first night was scheduled for 90 minutes, she said Tuesday, which includes only 65 minutes of interview.
Oprah said the interview will run over two nights because "we felt that to leave over half of this on the cutting-room floor, after millions of people have been waiting for years for many of these answers, would not be the right thing to do."


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Oil injection equipment and pressure media
SKF supplies oil injection equipment for installing and removing sleeves. For additional information, refer to Maintenance products.
When selecting a suitable pump, keep in mind that the maximum permissible pressure should be considerably higher than the calculated surface pressure.
For installation, SKF recommends using the SKF mounting fluid LHMF 300. The fluid has a viscosity of 300 mm2/s at 20 °C (70 °F). The advantage of this mounting fluid is that when installation is complete, the fluid will leave the joint quickly and completely so that metal-to metal contact is restored relatively quickly.
For removal, SKF recommends using the SKF dismounting fluid LHDF 900. With a viscosity of 900 mm2/s at 20 °C (70 °F), the fluid will provide an adequate oil film, even if the mating surface of the sleeve or shaft is scratched. Keep in mind that the fluid has a low flow rate and the permissible pressure of the oil injection equipment should never be exceeded.


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Key Largo (film)
From Quotes
Happiness is the interval between periods of unhappiness.Don Marquis
Key Largo is a 1948 film about a veteran soldier who visits the family of an army buddy killed in the war, only to find that their Key West hotel has been taken over by a bunch of exiled gangsters who are orchestrating their own comeback.
- Directed by John Huston. Written by Maxwell Anderson, Richard Brooks and John Huston.
Frank McCloud
- You don't like it, do you Rocco, the storm? Show it your gun, why don't you? If it doesn't stop, shoot it.
- When your head says one thing and your whole life says another, your head always loses.
- One Rocco more or less isn't worth dying for!
Johnny Rocco
- After living in the USA for more than thirty-five years they called me an undesirable alien. Me. Johnny Rocco. Like I was a dirty Red or something!
- You'd give your left arm to nail me wouldn't you? I could see the headlines now, 'Local Deputy Captures Johnny Rocco'. Your picture'd be in all the papers. You might even get to tell on the newsreels how you pulled if off, yeah. Listen hick, I was too much for any big city police force to handle. It took the United States Government to pin a rap on me. And they won't make it stick. You hick, I'll be back pulling strings to get guys elected mayor and governor before you get a ten buck raise.
Nora Temple
- Charlie! Charlie Winook and his family, Crawfish Island. Charlie's a prince of the Seminole Nation. His ancestors go back to the gods. He sells sea shells by the sea shore.
- Edward "Toots" Bass: I say smack her and let it go at that.
- James Temple: Are you thieves or what? You want money, is this a robbery?
- Toots: Yeah, Pop, we're gonna steal all your towels.
- Ralph Feeney: Hey Curly, what all happens in a hurricane?
- Richard "Curly" Hoff: The wind blows so hard the ocean gets up on its hind legs and walks right across the land.
- Toots: And singin' this song: Rain rain, go away, little Ralphie wants to play.
- Humphrey Bogart — Frank McCloud
- Edward G. Robinson — Johnny Rocco
- Laruen Bacall — Nora Temple
- Harry Lewis — Edward "Toots" Bass
- Thomas Gomez — Richard "Curly" Hoff
- Lionel Barrymore — James Temple
- William Haade — Ralph Feeney
External links
- Key Largo quotes at the Internet Movie Database


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Leah Remini on Leaving Scientology: "I'm Not About to Shut Up"
Jul 29, 2013 11:18 AM EDT
Leah Remini is continuing to speak out about her split from the Church of Scientology, despite efforts on the part of church leaders to silence the actress. "I believe that people should be able to question things," Remini tells People. "No one is go… Read more


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Vancouver, BC – March 31, 2009 – Avigilon, today, announced Avigilon Control Center 4.0, the company's latest version of its award-winning High Definition (HD) surveillance software, which will be demonstrated at the ISC West conference taking place April 1 – 3rd in Las Vegas. With new features to improve performance and manageability, Avigilon Control Center 4.0 also offers support for third party IP cameras, becoming a truly open enterprise class network video management software platform.
The reference designs offer a cost-effective electronic bill of materials (eBOM) at less than $40 for the IP camera and $60 for the DVR, while also including a full complement of analog ICs, ranging from power management to interface devices from TI. This enables customers to quickly create cost-sensitive products such as IP cameras, IP modules for closed-circuit TV cameras, digital video servers (DVS), DVRs and network video recorders (NVR), reducing development time from approximately 160 man months to only four months.
Apparently attracted to electrical equipment, the ants invade by the millions and can shut down anything from computer systems and communications networks to hospital data bases and airport security control panels, he said. Repairs might cost millions.
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On the Editor's DeskPaul Ragusa
News and notes
Monitoring MattersGinger Hill
Guest Blog
© 2019 United Publications ALL RIGHTS RESERVED.


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Nurses are in high demand and this is why men should consider becoming one
Tuesday, August 08, 2017
Nurses have always been in high demand. That's as true today as it always was, and the number and scope of nursing jobs is expanding every day. Nurses are more critical to the health care process then ever, and there is currently a shortage of qualified nurses! (And a shortage of primary care physicians … so nurses are even more in constant demand!)
As health care demands continue to increase — along with costs — nursing will become even more crucial. In the past, a career in nursing hasn't been on the radars of many professional men, as it is a career more traditionally filled by women. But really, why not even consider an entire booming career path, one with opportunity for great compensation, job security, and other benefits that might increase your quality of life?
Here are some good reasons why men should roll up the sleeves of their scrubs and get involved.
Why not?
Would you tell your kid to overlook an entire in-demand and lucrative, rewarding career path just because it's traditionally been a field for one gender or the other? Of course not. So why would you overlook it? The biggest obstacle you'd have to clear as a dude entering the profession would be your own gender stereotypes. Nursing is a highly valued and very sturdy career choice. Why let tired gender stereotypes keep this work only for the ladies?
If you're reading this and considering nursing, congrats! You're already over that hump! If you can be mentored and trained by highly competent women in a highly technical and demanding field, then you're good to go.
Show you're an enlightened guy and join this under-appreciated field. Then join an organization like the American Assembly of Men in Nursing for extra support while you break into your new career.
You can specialize.
Whatever picture you have in your head for what a nurse's job is like, you're probably wrong. But probably you also didn't realize just how wide the options are for specialization in the field. Try any number of fields, such as anesthesia, flight, emergency, trauma nursing. Even middle management, nursing education, nurse practitioner work, oncology, psychiatry, pediatrics, and administration.
Find your interest, claim your niche and pursue whichever part of this wide-ranging profession that interests you. Don't get us wrong — you of course will have to start with the basics and build a solid foundation. But once you do, you have the freedom (and opportunity) to make it your own.
You will likely be well-compensated.
Like in most professions, male nurses tend to out-earn female nurses.Hey, this might not be fair, but it's true. Right out of the gate, you're more likely to be compensated (more) fairly for your time and work. It's a consistent and reliable career choice wherein you have a financial leg up. Just be sure once you get hired, you start fighting for fair pay for your female colleagues. After all, they're just as qualified and overworked as you will be.
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Cuisinart Multi-Cooker, 7-Qt.
Use this handy countertop appliance to sear, sauté, roast, slow-cook and steam – all in one pot. Just add ingredients and press a button. After cooking, the machine automatically keeps food at the perfect serving temperature until it's time to eat.
- Four fully programmable cooking functions include Slow Cook, Roast, Brown/Sauté and Steam.
- Slow cook on high, low, simmer or warm for up to 24 hours.
- Temperature can be set as high as a searing 500°F.
- Automatic "keep warm" function ensures food is hot and ready to serve.
- Set to steam for up to 90 minutes.
- Removable large 7-quart nonstick cast-aluminum pot and lid are dishwasher safe.
- Check cooking time and temperature from across the kitchen or in low light with the large blue backlit LCD display.
- The glass lid's handle stays cool to the touch.
- Includes a reversible roasting/steaming rack.
Dimensions & More Info
- 15 1/2" x 19" x 11" high.
- 7-qt. cap.
More Information
- This product is intended for use in the United States and Canada, and is built to U.S. electrical standards.
- Made in China.
Use & Care
- Do not exceed 60% capacity when filling with food or liquid.
- Use wood, plastic or heat-resistant nylon tools to avoid scratching the nonstick surface.
- Nonstick cooking bowl and lid are dishwasher safe.
- Clean exterior with damp cloth and dry thoroughly.
Price Match Guarantee
Williams Sonoma Price Match Guarantee
At Williams Sonoma, we're committed to bringing you the best quality at the best prices.
If you find a lower price on any of our products, we'll match it—guaranteed. Click here for details.
Shipping Information
UPS can deliver most in-stock items within 3–5 business days. UPS is unable to deliver to P.O. boxes.
Shipping Rates
The shipping rate varies depending on your order total and shipping destination. View Shipping Options and Charges.
Next Day Delivery
For an additional charge of $26 per address, we can expedite delivery to most destinations. This service is not available for some oversize items, items shipped directly from the supplier (including perishable and custom-manufactured items), out-of-stock items and items to be shipped outside the contiguous 48 states.
Orders received by 9:00 p.m. ET Monday through Thursday will arrive the next business day; orders placed Friday through Sunday will arrive on the following Tuesday.
Return Policy
At Williams Sonoma, we take great pride in the quality and craftsmanship of our products. Attention to design, materials, safety and construction are our priority. Upon receipt, please inspect your purchase and notify us of any damage; we will arrange for a prompt replacement.
If within 30 days, you are dissatisfied for any reason, you may return your purchase for a refund of the merchandise value. An original receipt or gift receipt is required for all returns and exchanges. Returns with a gift receipt will be refunded in the form of a Merchandise Credit for the amount indicated on the gift receipt. Returns with original receipt will be refunded in the original form of payment, cash and check refunds over $100 will be issued as a company check (may take 14 business days from time of request).
For all cutlery returns (knife sets, single knives, cutting boards, knife sharpeners and knife storage), please contact us at 888.922.4108 to initiate the return.
We cannot accept returns on monogrammed, personalized, special-order items, custom upholstery, food, items shipped direct from the vendor or on items damaged through normal wear and tear. Final sale items ending in .97 or .99 cannot be returned.
Made to Order and Final Sale Furniture items are non-returnable and cannot be cancelled once the order is placed.
For returns of items purchased from your Williams Sonoma Gift Registry, we will gladly provide a refund or exchange for the merchandise within 90 days of your event or within 90 days of purchase, whichever date is later. View Full Returns Policy.
Cuisinart Multi-Cooker, 7-Qt.
|Delivery Surcharge
|Cuisinart Multicooker
|Sugg. Price $365 Our Price $199.95


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September 6, 1995, Section A, Page 1Buy Reprints
Speaking more forcefully on human rights than any American dignitary has on Chinese soil, Hillary Rodham Clinton catalogued a devastating litany of abuse that has afflicted women around the world today and criticized China for seeking to limit free and open discussion of women's issues here.
"It is time for us to say here in Beijing, and the world to hear, that it is no longer acceptable to discuss women's rights as separate from human rights," Mrs. Clinton told the Fourth World Conference on Women assembled here.
"It is a violation of human rights when babies are denied food, or drowned, or suffocated, or their spines broken, simply because they are born girls," Mrs. Clinton said, or "when women and girls are sold into slavery or prostitution for human greed.
"It is a violation of human rights when women are doused with gasoline, set on fire and burned to death because their marriage dowries are deemed too small" she continued, or "when thousands of women are raped in their own communities and when thousands of women are subjected to rape as a tactic or prize of war."
While her comments concerned abuses that have taken place around the world -- the burning of brides occurs in India for example, and rape has most recently been a tactic of war in Bosnia -- her words took on a special resonance here in China, where the Administration has muted its public criticism of human rights abuses and is struggling to patch up frayed political relations.
China has been widely criticized for forcing women to be sterilized or have abortions as part of its policy of one child per family, and there are wide reports of female infanticide by parents who want a son.
China's reaction was uncertain tonight. Beijing's relations with Washington have been strained by a summer of tumult over the visit to the United States in June by the president of Taiwan, Lee Teng-hui.
Mrs. Clinton's gravity and directness seemed to please both Democratic and Republican members of the United States delegation here, and thus the speech may trump the political disputes that have plagued both Mrs. Clinton's decision to travel here and the Administration's approach to China.
She delivered her remarks after joining hundreds of delegates in a morning workshop on "women and health security."
Addressing the full conference in the afternoon, Mrs. Clinton expanded on a theme that Pakistan's Prime Minister, Benazir Bhutto, raised on Monday when she told the delegates that violence against women thrives when there is a "crisis of silence and acquiescence."
As Mrs. Clinton recited her litany from the podium, many delegates applauded, some cheered and others pounded the tables.
Continuing with references to domestic violence, genital mutilation, coercive abortions and sterilizations, Mrs. Clinton told the delegates from more than 180 countries, "If there is one message that echoes forth from this conference, let it be that human rights are women's rights and women's rights are human rights, once and for all."
A senior Administration official traveling with Mrs. Clinton was at pains after the address to explain that it did not mark a return to a more vocal confrontation with China over its poor human rights record. In recent months, Washington has sought to tone down its public remarks on human rights abuses in favor of a more private dialogue that had few results.
"There is nothing in her speech that in any way deviates from our approach on China," the official said, "or on our desire to get the relationship stabilized and to get some momentum going. This is a United Nations conference and she was speaking out on a global problem."
One of the Democratic Congresswomen here, Carolyn B. Maloney of New York, said she believed that Mrs. Clinton spoke from personal conviction after she became acquainted firsthand with some problems of women in the third world on a tour of Pakistan and India earlier this year.
"I think she spoke from the heart and she spoke with great power," Ms. Maloney said.
Representative Christopher H. Smith, Republican of New Jersey, who had called on Mrs. Clinton to speak out against "barbaric and egregious" human rights abuses in China during this trip, said he was satisfied to a great extent with her speech, but believed she could have been even more specific in criticizing China's abuses. He called her speech "eloquent" and praised her for "raising the issue" in China.
Still, the impact of the speech seemed to reverberate through the hall.
"She talked so eloquently about human rights, and I thought it was very effective, because all of the women here will know that the wife of the President of the United States also thinks about these things," said Maria Kamm, a delegate from Tanzania and member of Parliament there.
In the section of her speech aimed most directly at China, Mrs. Clinton seemed to betray frustration over China's intolerance for dissenting views.
A number of delegates, including exiles from Tibet and leaders from Taiwan, were denied visas to attend this meeting and a parallel gathering of private women's organizations.
"Freedom means the right of people to assemble, organize, and debate openly," Mrs. Clinton admonished her Chinese hosts. "It means respecting the views of those who may disagree with the views of their governments. It means not taking citizens away from their loved ones and jailing them, mistreating them, or denying them their freedom or dignity because of peaceful expression of their ideas and opinions."
Ordinary Chinese citizens did not see or hear Mrs. Clinton's speech, which was blacked out on official radio and television. There are 5,000 Chinese delegates, all selected by the Communist Party and all with strong ties to the party or the Government. Others were restricted from even coming near the conference site. Their news was limited to a carefully scripted menu, featuring a blizzard of ethusiastic propaganda on the enormous progrss of Chinese women under the party's guidance.
The senior party official in attendance today, Chen Muhua, refused later to take any questions on the speech. "I'm sorry, I'm very busy," she said. The official Chinese press was under instructions to ignore Mrs. Clinton's remarks until an official reaction had been considered.
Afterward, Mrs. Clinton said she hoped the Chinese had gotten the message of her speech. "I think it is important that all governments which in any way infringe on human rights know that this conference takes a strong stand and that this conference is trying to move toward the realization of human rights," she told a news conference.
She said President Clinton's goal is to remain "engaged" with China in a broad and comprehensive relationship, but added, "we are trying to have an honest relationship."
"To me, it was important to express how I felt and to do so as clearly as I could," she said.
Thousands of Chinese women who were interested in attending these sessions simply had no opportunity to apply or gain access to the gathering.