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This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.
This complementary and alternative medicine (CAM) information summary provides an overview of the use of milk thistle as a treatment and adjunct agent for people with cancer.
The summary includes a brief history of milk thistle, a review of the laboratory studies and clinical trials, and a description of adverse effects associated with milk thistle use.
This summary contains the following key information:
Many of the medical and scientific terms used in the summary are hypertext linked (at first use in each section) to the NCI Dictionary of Cancer Terms, which is oriented toward nonexperts. When a linked term is clicked, a definition will appear in a separate window.
Reference citations in some PDQ CAM information summaries may include links to external Web sites that are operated by individuals or organizations for the purpose of marketing or advocating the use of specific treatments or products. These reference citations are included for informational purposes only. Their inclusion should not be viewed as an endorsement of the content of the Web sites, or of any treatment or product, by the PDQ Cancer CAM Editorial Board or the National Cancer Institute.
The botanical name for milk thistle is Silybum marianum (L.) Gaertn. Milk thistle is also referred to as holy thistle, Marian thistle, Mary thistle, Our Lady's thistle, St. Mary thistle, wild artichoke, Mariendistel (German), and Chardon-Marie (French). The plant is indigenous to Europe but can also be found in the United States and South America. Traditionally, the leaves have been used in salads, and the fruit of the flower has been roasted as a coffee substitute. The seeds of milk thistle are the medicinal parts of the plant.[1] The primary active constituent of milk thistle is silymarin, which is composed of four isomers: silybin, isosilybin, silychristin, and silydianin. Most supplements are standardized according to their silybin content. In turn, silybin and isosilybin are both mixtures of two diastereomers, silybins A and B and isosilybins A and B, respectively.[2] Special formulations of silybin have been developed to enhance the bioavailability of the herbal product; these forms are sold under the names Legalon, silipide, and Siliphos. Because of milk thistle's lipophilic nature, it is usually administered in capsule or tablet form rather than as an herbal tea. In Europe, silybin is administered intravenously as the only effective antidote for Amanita phalloides (Fr.) Link toxin.[3] Humans exposed to this mushroom toxin develop serious liver failure that ultimately progresses to death.
Several companies distribute milk thistle as a dietary supplement. In the United States, dietary supplements are regulated as foods, not drugs. Therefore, premarket evaluation and approval by the Food and Drug Administration (FDA) are not required unless specific disease prevention or treatment claims are made. Because dietary supplements are not formally reviewed for manufacturing consistency, ingredients may vary considerably from lot to lot; in addition, there is no guarantee that ingredients identified on product labels are present at all or are present in the specified amounts. It is important to note that the FDA has not approved the use of milk thistle as a treatment for cancer patients or patients with any other medical condition.
To conduct clinical drug research in the United States, researchers must file an Investigational New Drug (IND) application with the FDA. The IND application process is confidential, and IND information can be disclosed only by the applicants. To date, only one investigator has announced holding an IND to study milk thistle as an adjunct cancer treatment.
Despite milk thistle's long history of being used to treat liver and biliary complaints, it was not until 1968 that silymarin was isolated from the seeds of the plant, and it was proposed that silymarin might be the active ingredient.[4] Silymarin was later determined to be a flavonolignan that is composed of four structurally similar compounds: silybin, isosilybin, silydianin, and silychristin.[2] Researchers have investigated the role that silibinin may play in the treatment of hepatitis and cirrhosis. Most studies have investigated the isolated compound silymarin or its most active isomer silybin, rather than the herbal plant in its whole form.
Silymarin is most well known for its purported effects on the liver. In laboratory studies, silymarin has been found to stabilize cell membranes, thus preventing toxic chemicals from entering the cell.[3,5,6,7] Laboratory studies have also demonstrated that silymarin stimulates synthesis and activity of enzymes responsible for detoxification pathways and exhibits antioxidant properties.[6,7,8,9,10,11,12,13,14,15,16,17] Specifically, silymarin has been shown to stimulate the glutathione S-transferase pathway and alter the intracellular concentration of glutathione (a potent antioxidant). Silymarin has also been shown to neutralize a wide range of free radicals.
Laboratory experiments conducted using cancer cell lines have suggested that silibinin enhances the efficacy of cisplatin and doxorubicin against ovarian and breast cancer cells.[18] Silybin appears to have direct anticancer effects against prostate, breast, and ectocervical tumor cells.[19] Silybin may also affect the cell cycle in cancer cells by slowing down cell growth, as demonstrated with prostate cancer cell lines.[20] Laboratory studies using leukemia cell lines found that silybin did not stimulate growth of leukemia cells.[21]
No human clinical trials on milk thistle or silymarin as a cancer treatment or as an adjunctive therapy in individuals with cancer have been published. Most clinical trials have investigated silymarin's effectiveness in the treatment of patients with hepatitis, cirrhosis, or biliary disorders.[22,23,24,25,26,27,28,29,30,31] These studies have employed a wide range of doses (120–560 mg /day) and have yielded conflicting results. Many of the well-designed, large-scale trials have reported a beneficial effect rather than no effect. The most commonly reported adverse effects are a mild laxative effect and gastrointestinal upset.
Milk thistle has been used for more than 2,000 years, primarily as a treatment for liver dysfunction. The oldest reported use of milk thistle was by Dioscorides, who recommended the herb as a treatment for serpent bites.[1] Pliny the Elder (A.D. 23–79) reported that the juice of the plant mixed with honey is indicated for "carrying off bile."[1,2] In the Middle Ages, milk thistle was revered as an antidote for liver toxins.[1,2] The British herbalist Culpepper reported it to be effective for relieving obstructions of the liver.[1,2] In 1898, eclectic physicians Felter and Lloyd stated the herb was good for congestion of the liver, spleen, and kidney.[1,2] Native Americans use milk thistle to treat boils and other skin diseases. Homeopathic practitioners used preparations from the seeds to treat jaundice, gallstones, peritonitis, hemorrhage, bronchitis, and varicose veins.[2] The German Commission E recommends milk thistle use for dyspeptic complaints, toxin-induced liver damage, hepatic cirrhosis, and as a supportive therapy for chronic inflammatory liver conditions.[3]
Research studies conducted in the laboratory have investigated the properties of silymarin or its isomer silybin using cell lines and animal models. Other substances in milk thistle have not been extensively studied.
Several research studies have investigated the effects of silymarin or silybin in a noncancer context. These studies have tested silymarin or silybin:
Silymarin or silybin has also been investigated in cancer models. The effects of silymarin and/or silybin have been investigated in prostate (DU 145, LNCaP, PC-3),[1,2,3,4,5,6]breast (MDA-MB 468, MCF-7),[7,8,9]hepatic (HepG2),[10,11] epidermoid (A431),[11]colon (Caco-2),[12]ovarian (OVCA 433, A2780),[13]histiocytic lymphoma (U-937),[14] and leukemia (HL-60) [15,16]cells. In animal tumor models, tongue cancer,[17] skin cancer,[18,19,20,21,22,23]bladder cancer,[24] and adenocarcinoma of the colon [25,26] and small intestine [26] have been investigated. These studies have tested the ability of silymarin or silibinin to:
Although many of these studies have produced encouraging results, none of the findings have been replicated in human clinical trials.
Laboratory data suggest that silymarin and silybin protect the liver from damage induced by toxic chemicals. Animal studies have found that liver cells treated with silybin and then exposed to toxins do not incur cell damage or death at the same rate as liver cells that are not treated with silybin. This finding suggests that silybin can prevent toxins from entering the cell or effectively exports toxins out of the cell before damage ensues.[11,27,28,29,30,31] Alternatively, this may be related to the effect of silymarin on detoxification systems. In vitro data have shown silybin to stimulate and/or inhibit phase I detoxification pathways in silybin-treated human liver cells. However, this effect was found to be dose-dependent, and these levels are not physiologically attainable with the current manufacturer dose recommendations.[32,33]
Silymarin has been shown to stimulate phase II detoxification pathways in mice. Administration of silymarin (100 or 200 mg /kg body weight/day) to SENCAR mice for 3 days significantly increased glutathione S-transferase activity in the liver (P < .01–.001), lung (P < .05–.01), stomach (P < .05), small bowel (P < .01), and skin (P < .01). This effect appeared to be dose-dependent.[34] Administration of silymarin to rats challenged with a toxin (50 mg/kg body weight) resulted in higher levels of glutathione in liver cells, decreased levels of oxidative stress (measured by malondialdehyde concentrations), and less elevated liver function tests (measured by levels of aspartate aminotransferase [AST] and alanine aminotransferase [ALT]).[31] Silymarin and silybin have also been found to accelerate cell regeneration in the liver through stimulation of precursors to DNA synthesis and enhancement of production of the cellular enzymes required for synthesis of DNA.[35,36,37,38,39,40] Laboratory studies have also shown silymarin and silybin to be potent antioxidants.[28,29,41,42,43,44,45,46,47,48] Silymarin has been shown to mitigate oxidative stress in cells treated with pro-oxidant compounds.
A number of laboratory studies have investigated the effect of silymarin or silybin on the efficacy and toxicity of chemotherapy agents or have measured their direct cytotoxic activity. In an investigation of the effect of a variety of flavonoids on the formation of DNA damage, silymarin did not induce DNA damage in colon (Caco-2) cells, hepatoma (HepG2) cells, and human lymphocytes.[12] At higher concentrations of silymarin (400–1,000 μmol/L) DNA damage was induced in an epithelial cell line (HeLa cells). At higher concentrations (1,000 μmol/L) DNA damage was observed in human lymphocytes. Cell growth was inhibited as the flavonoid concentration was increased in human lymphocytes and HeLa cells. Only at very high concentrations was cell viability affected by silymarin in HepG2 cells. Although this study demonstrated that the flavonolignans of Silybum marianum (L.) are capable of inhibiting cellular proliferation and inducing DNA strand breaks, the results were obtained at very high concentrations that may be difficult to achieve in humans. This study also showed that silymarin does not stimulate cell growth in the HeLa, Burkitt lymphoma, and human hepatoma cell lines.
Silymarin has also been investigated as a possible adjunctive agent in mitigating some of the toxicity associated with chemotherapy agents. Silybin and silychristin exerted a protective effect on monkey kidney cells exposed to vincristine and especially cisplatin chemotherapy.[49] Silybin (200 mg/kg body weight) administration with cisplatin in rats resulted in statistically significant reductions in measures of kidney toxicity.[50] Significant decreases in weight loss, faster recovery of urinary osmolality measures, and depressions in the increase in activity of urinary alanine aminopeptidase ([AAP], a marker of kidney toxicity) were observed. Silybin had no effect on magnesium excretion or glomerular function. Silybin (2 g /kg body weight) administration in rats receiving cisplatin prevented reductions in creatinine clearance, increases in urea plasma levels, and large increases in urinary AAP.[51] No effect on magnesium excretion was observed. Silybin did not interfere with the antineoplastic effects of cisplatin or ifosfamide in germ cell tumors. In experiments with ovarian and breast cancer cell lines, silybin potentiated the effect of cisplatin and doxorubicin.[13] IdB 1,016, a form of silybin bound to a phospholipid complex, was found to enhance the activity of cisplatin against A2780 ovarian cancer cells but had no effect on its own.[52] Silybin increased the chemosensitivity of DU 145 prostate cancer cells resistant to chemotherapy.[53]
Studies have also investigated the effect of silymarin on tumor initiation and promotion. Silymarin appears to have a chemopreventive effect through perturbations in the cell cycle, altering cell signaling that induces cellular proliferation, affecting angiogenesis, or through its anti-inflammatory properties.[1,7,13,19,54] These findings have been supported in human prostate, breast, ectocervical, ovarian, hepatic, leukemia, and epidermoid cell lines.[4,7,9,10,15,55] An investigation of the effect of silymarin on ultraviolet B radiation-induced nonmelanoma skin cancer in mice found that silymarin treatment significantly reduced tumor incidence (P < .003), tumor multiplicity (P < .0001), and tumor volume (P < .0001).[19] These findings suggest that silymarin plays a prominent role in the reduction of cancer cells and in preventing the formation of cancer cells. A number of studies have investigated the mechanism through, which silymarin may affect tumor promotion in mouse skin tumor models. Studies have found that silymarin reduces transcription of markers of tumor promotion and activity,[19] inhibits transcription of tumor promoters,[56] stimulates antioxidant activities,[19,23] interferes with cell signaling,[55] inhibits inflammatory actions,[19,22] and modulates cell-cycle regulation.[57]
In prostate cancer cell lines, silybin has been shown to inhibit growth factors and stimulate cell growth,[1,2,3,5] promote cell cycle arrest,[1,4] and inhibit antiapoptotic activity.[53] In rats with azoxymethane -induced colon cancer, dietary silymarin resulted in a reduction in the incidence and multiplicity of adenocarcinoma of the colon in a dose-dependent manner.[25,26] Dietary silymarin had no effect on small intestinal adenocarcinoma,[26] but exerted a preventive effect in mice with N-butyl-N-(4-hydroxybutyl) nitrosamine –induced bladder cancer [24] and in F344 rats with 4-nitroquinoline 1-oxide –induced cancer of the tongue.[17] Dietary silybin administered to nude mice with prostate carcinoma increased production of insulin -like growth factor-binding protein-3 in the plasma of mice and significantly inhibited tumor volume (P < .05).[2] Silibinin administered twice daily reduced the growth of colorectal tumor xenografts in mice for a period of 6 weeks.[58,59]
Two published case reports describe the use of milk thistle as either a treatment or an adjunctive therapy in individuals with cancer. One case report describes the use of milk thistle in a 34-year-old woman with promyelocytic leukemia.[1] The investigators administered 800 mg of silymarin during the patient's maintenance therapy, which consisted of treatment with methotrexate and 6-mercaptopurine. During the 4 months of treatment with silymarin, the patient who previously required intermittent breaks in therapy due to abnormal liver enzyme levels had normal liver enzyme levels with no further interruption of therapy. A second case report describes a 52-year-old man with hepatocellular carcinoma.[2] The patient began taking 450 mg of silymarin per day, and spontaneous regression of the tumor was reported in the absence of initiation of anticancer therapy.
In a double-blind, placebo-controlled trial, 50 children who were undergoing treatment for acute lymphoblastic leukemia and who had chemotherapy -related hepatotoxicity were randomly assigned to receive silymarin or placebo for a 4-week period.[3] Four weeks following completion of the intervention, the silymarin group had a significantly lower aspartate aminotransferase (AST) (P = .05) and a trend towards a significantly lower alanine aminotransferase (ALT) (P = .07). Fewer chemotherapy dose reductions were observed in the silymarin group compared to the placebo group; however, the difference was not significant. No adverse events were reported.
Most clinical trials of milk thistle have been conducted in patients with either hepatitis or cirrhosis. Other studies have investigated milk thistle in patients with hyperlipidemia, diabetes, and Amanita phalloides mushroom poisoning. Ten randomized trials [3,4,5,6,7,8,9,10,11,12] have been reported in patients with hepatitis or cirrhosis, and one randomized trial has reported the use of silymarin as a prophylaxis to iatrogenic hepatic toxicity.[13]Endpoints for these trials have included serum levels of bilirubin and/or the liver enzymes AST and ALT, as higher levels are an indicator of liver inflammation, damage, or disease. The lowering of these serum levels is a sign of an improving condition. In patients with hepatitis A and B, one clinical trial found silymarin (140 mg daily for 3–4 weeks) resulting in lower levels of AST, ALT, and bilirubin by day 5, compared with a placebo group.[14] In another randomized, placebo-controlled study of patients with viral hepatitis B, silymarin (210 mg daily) had no effect on course of disease or enzyme levels.[7]
A randomized, controlled trial supported by the National Institute of Diabetes and Digestive and Kidney Diseases examined patients with chronic hepatitis C who had failed prior antiviral therapy. All patients had advanced chronic liver disease consisting of histologic evidence of either marked fibrosis or cirrhosis. The Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis trial used a half dose of pegylated interferon versus no treatment; the treatment was to be administered for 3.5 years.[12] The aim was to reduce progression of chronic hepatitis C, particularly in the development of hepatocellular carcinoma. Among 1,145 study participants, 56% had never taken herbals, 21% admitted past use, and 23% were using herbals at enrollment. Silymarin constituted 72% of the 60 herbals used at enrollment. Users had significantly fewer symptoms and a better quality of life than nonusers.
Although there are many reports of the use of herbals for the treatment of chronic liver diseases, most treatment trials have suffered from poor scientific design, uncertainty of the required dosage of herbals, and an insufficient number of study participants. A recent review of complementary and alternative medications (CAM) to treat liver diseases focused on the classification, epidemiology, and the philosophy of CAM and reviewed the criteria needed to conduct a scientifically valid research study focusing on herbal products.[15]
There has been skepticism regarding the evidence that silymarin has a direct impact on the hepatitis C virus (HCV)—some studies suggest that it does, but most studies are unable to confirm these reports. However, at least two articles in major journals have suggested that silymarin or its congeners may inhibit HCV. In one report, investigators found that a standardized silymarin extract inhibited tumor necrosis factor -alpha in anti-CD3–stimulated human peripheral blood mononuclear cells and nuclear factor-kappa B-dependent transcription in human hepatoma Huh-7 cells.[16] Silymarin also displayed prophylactic and therapeutic effects against HCV infection and when combined with interferon-alpha, was more inhibitory of HCV replication than was interferon alone. This indicates that silymarin has anti-inflammatory and antiviral effects in patients with chronic hepatitis C.
In a case series /phase I study, patients with HCV were treated with intravenous silibinin with and without PEG-interferon and ribavirin.[17] In the case series, 16 HCV nonresponder patients were administered intravenous silibinin in a dose of 10 mg/kg/day for 7 days. Subjects then began treatment with oral silibinin in combination with PEG-interferon and ribavirin for 12 weeks. At the end of the study period, all patients were positive for HCV RNA, but 5 of 13 completed patients had reductions in HCV RNA. Significance was not reported. In the same study, the authors presented results of a phase I study in which 20 patients were administered 5 mg/kg, 10 mg/kg, 15 mg/kg, or 20 mg/kg of silibinin for 14 days in combination with PEG-interferon and ribavirin (initiated on day 8). A significant drop in HCV RNA was observed on day 7 in patients administered the 10 mg/kg, 15 mg/kg, and 20 mg/kg doses of silybinin. Further declines were observed in HCV RNA with administration of PEG-interferon and ribavirin. Except for mild gastroenteritis, intravenous silibinin monotherapy was well tolerated.
In patients with chronic liver disease, a randomized, placebo-controlled study found normalization of serum AST, ALT, and bilirubin levels after 1 month of treatment with silymarin (140 mg 3 times a day) in comparison to treatment with a placebo.[18] In one of the largest observational studies involving 2,637 patients with chronic liver disease, 8-week treatment with 560 mg/day of silymarin resulted in reductions of serum AST, ALT, and gamma-glutamyltranspeptidase ([GGT], a marker of bile duct disease) and a decrease in the frequency of palpable hepatomegaly.[19]
Another published report describes the use of silybinin as the only effective antidote in patients with liver damage from Amanita phalloides (Fr.) Link poisoning.[20] Patients were administered doses of 35 to 55 mg/kg body weight, with no reports of adverse events. A recent retrospective review of the treatment for Amanita phalloides poisoning suggests that silymarin continues to be a promising drug in the treatment of this rare mushroom poisoning.[21] The beneficial effect of silymarin on liver histology suggests it has a role in the prevention of hepatitis and/or hepatocellular carcinoma; however, no clinical trials in humans have investigated these uses of silymarin.
Current Clinical Trials
Check NCI's list of cancer clinical trials for cancer CAM clinical trials on milk thistle and silymarin that are actively enrolling patients.
General information about clinical trials is also available from the NCI Web site.
Human studies of silymarin have shown minimal adverse effects in multiple large, blinded, placebo-controlled, randomized studies. Silymarin is well tolerated, with only rare reports of a mild laxative effect. Mild allergic reactions have been seen at high doses (>1,500 mg /day), although the details of these allergic reactions were not reported.[1] A recent case report from Australia described a reaction to a milk thistle extract that included intermittent episodes of sweating, abdominal cramping, nausea, vomiting, diarrhea, and weakness.[2] All symptoms resolved when the silymarin was discontinued. The authors suggested that the capsules were contaminated; the type of contamination was unknown.
According to the German Commission E, there are no reported side effects with milk thistle within the recommended doses. Rare cases of milk thistle having a laxative effect have been reported. Human studies have reported stomach upset, heartburn, and transient headaches; however, none of these symptoms were attributed to supplementation with milk thistle, and supplementation was not discontinued.[3] One human dosing study reported nausea, heartburn, and dyspepsia in patients treated with 160 mg/day, dyspepsia in patients treated with 240 mg/day, and postprandial nausea and meteorism in patients treated with 360 mg/day. None of these side effects were dose related.
Silymarin has been well tolerated in high doses. Silymarin has been used in pregnant women with intrahepatic cholestasis at doses of 560 mg/day for 16 days, with no toxicity to the patient or the fetus.[4] The published data on silymarin use in children focuses on intravenous doses of 20 to 50 mg/kg body weight for mushroom poisoning.[5] Silymarin has also proved nontoxic in rats and mice when administered in doses as high as 5,000 mg/kg body weight. Rats and dogs have received silymarin at doses of 50 to 2,500 mg/kg body weight for a 12-month period. Investigations, including postmortem analyses, showed no evidence of toxicity.
It is not known whether milk thistle may reduce, enhance, or have no effect on the effectiveness of chemotherapy. Silymarin decreases the activity of the cytochrome P450 enzyme system, which is involved in the clearance of certain chemotherapy drugs.[6] However, the dose at which inhibition is observed is high and not achieved with oral intake of silymarin.[7] One study investigated the effects of silymarin on the pharmacokinetics of irinotecan. Oral administration of milk thistle (200 mg, a clinically relevant dose, 3 times per day) had no significant effects on the pharmacokinetics of irinotecan. The authors concluded that the recommended doses of milk thistle are too low to affect activity of CYP3A4 or UGT1A1 enzyme pathways.[8]
Theoretically, milk thistle may also interact adversely with chemotherapy drugs that exert their cytotoxic effects through the generation of free radicals. Silymarin and its metabolite inhibit P-glycoprotein–mediated cellular efflux, leading to the potentiation of doxorubicin cytotoxicity.[9] No trials have been performed to support or negate these theoretical considerations. No effects on indinavir and alcohol pharmacokinetics have been observed. Enhancement of antiarrhythmic effects of amiodarone in rats has been observed.[9]
To assist readers in evaluating the results of human studies of complementary and alternative medicine (CAM) treatments for cancer, the strength of the evidence (i.e., the levels of evidence) associated with each type of treatment is provided whenever possible. To qualify for a level of evidence analysis, a study must:
Separate levels of evidence scores are assigned to qualifying human studies on the basis of statistical strength of the study design and scientific strength of the treatment outcomes (i.e., endpoints) measured. The resulting two scores are then combined to produce an overall score. A level of evidence score cannot be assigned to milk thistle because there has been insufficient clinical research to date. For an explanation of the scores and additional information about levels of evidence analysis of CAM treatments for cancer, refer to Levels of Evidence for Human Studies of Cancer Complementary and Alternative Medicine.
Given the limited amount of human data, the use of milk thistle/silymarin as a treatment for cancer patients cannot be recommended outside the context of well-designed clinical trials.
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Editorial changes were made to this summary.
This summary is written and maintained by the PDQ Cancer Complementary and Alternative Medicine Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.
Purpose of This Summary
This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the use of milk thistle in the treatment of people with cancer. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.
Reviewers and Updates
This summary is reviewed regularly and updated as necessary by the PDQ Cancer Complementary and Alternative Medicine Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH).
Board members review recently published articles each month to determine whether an article should:
Changes to the summaries are made through a consensus process in which Board members evaluate the strength of the evidence in the published articles and determine how the article should be included in the summary.
The lead reviewers for Milk Thistle are:
Any comments or questions about the summary content should be submitted to Cancer.gov through the Web site's Contact Form. Do not contact the individual Board Members with questions or comments about the summaries. Board members will not respond to individual inquiries.
Levels of Evidence
Some of the reference citations in this summary are accompanied by a level-of-evidence designation. These designations are intended to help readers assess the strength of the evidence supporting the use of specific interventions or approaches. The PDQ Cancer Complementary and Alternative Medicine Editorial Board uses a formal evidence ranking system in developing its level-of-evidence designations.
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The preferred citation for this PDQ summary is:
National Cancer Institute: PDQ® Milk Thistle. Bethesda, MD: National Cancer Institute. Date last modified <MM/DD/YYYY>. Available at: http://cancer.gov/cancertopics/pdq/cam/milkthistle/HealthProfessional. Accessed <MM/DD/YYYY>.
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cute lil babies on the board.
Okay i have a silly question for those that breasfed. Mine has two lil teeth at the bottom lol and those things are sharp. Am still fully breastfeeding and boy he has turned to bitting. Do any of you have tricks to stop that habit.
Also he is showing more interest in food and pulling at everythin on the table. I still have not started him on any table food. I was trying to hold of till 9months but i think am going to give in and start cereal. any thoughts/ideas will be appreciated.

subset: commoncrawl


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Your kids will have fun imagining and pretending to be "On the Go" or exploring the interactive exhibits and kid's activities in our educational play space. Adults are welcome to join in on the adventure, or sit back and relax while their children discover a world that is just their size in our interactive children's museum.
$12 for each child ages 1-8*
*children younger or older are free if accompanied by a paying sibling
open play Hours
Monday – Friday: 9:00am – 5:00pm
For our Weekend Open Play by Reservation schedule click here.
Location + Contact
950 W Stacy Road, Suite 100
Allen, TX 75013
Admission is charged for children ages 1-8.*
Parents or guardians must sign a waiver for each child before entering the play space.
Please note that we are not a drop-off center or childcare facility. Parents and caregivers must stay in the play space and supervise their children at all times.
If at all possible, please do not bring strollers into play street museum.
Our restroom is outfitted with a baby changing station. Please change all diapers in the restroom.
We have free wi-fi.
We do not allow food in the play area....be sure to fill up your little one's belly before you arrive.
Outside drinks for children and adults are permitted and encouraged. Bring in your favorite drink and relax for a few!
We reserve the right to ask children that are being disruptive to leave if they are interfering with the learning & play of others.
*Admission is charged for children <1 year if they are not accompanied by a paying sibling
950 W Stacy Road, Suite 100 | Allen, TX 75013 | 972-737-3256
locally owned and passionately operated by a member of your community


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The Raiders announced Wednesday that they have signed Canadian Football League star running back Kory Sheets, the MVP of last season's Grey Cup.
In two seasons with the Saskatchewan Roughriders of the CFL, Sheets rushed for 2,875 yards and 23 touchdowns, and also caught 86 passes for 781 yards and two more TDs. In the Roughriders' Grey Cup win over the Hamilton Tiger-Cats, Sheets ran for 197 yards and two scores.
Sheets, who played collegiately at Purdue, entered the NFL in 2009 with the 49ers as an undrafted free agent. Later that season he joined the Miami Dolphins, where he played for two years. The 5-foot-11, 208-pounder spent the 2011 season with Carolina before heading to Canada.


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Thirsty, irritated winter skin clamors for extra attention. To give it the care it deserves, try this facial mask made with natural ingredients. The recipe includes moisturizing avocado, inflammation-fighting cucumber, and mineral-rich green clay, which helps to deep clean pores. A splash of lemon juice adds alpha-hydroxy acids to break down dead cells, and a quick chill in the fridge ensures that the mask will reduce redness and irritation. Even if the forecast holds nothing but cold, blustery days ahead, your skin's outlook will be perfectly clear.
Balancing Facial Mask
1 small avocado, mashed (about 2/3 cup)
1/2 small cucumber, finely grated (about 1/3 cup)
1 teaspoon fresh lemon juice
3 tablespoons green clay powder (sold at natural-foods stores)
Combine all ingredients in a small bowl, using a fork to blend. Cover and chill in the refrigerator for at least 30 minutes. Apply a thick layer of the mixture to clean, dry skin on your face and neck, avoiding the eye and lip areas. Keep fairly still for 10 to 15 minutes, allowing the mask to dry in place. Wipe skin clean with a damp cloth; splash with cool water, and pat dry.
Learn how to make Do It Yourself Toner.


text: Photos: Astronaut Chris Hadfield's Twitpics from spaceChris Hadfield, @Cmdr_Hadfield, Twitter 01.01.2013The beauty of the Bahamas is surreal; every blue that exists. Taken on New Year's Day, 2013 from the Space Station.Chris Hadfield / @Cmdr_Hadfield, TwitterOttawa, Ontario in Snow - how it looked today from ISS - 30 Dec at 12:40.Chris Hadfield / @Cmdr_Hadfield, TwitterKingston, Ontario in snow - how it looked from ISS today, 30 Dec at 12:40.Chris Hadfield / @Cmdr_Hadfield, TwitterCambridge, Ontario in the snow, on the last day of 2012.Chris Hadfield / @Cmdr_Hadfield, TwitterP.E.I. on the last day of 2012, as seen from a window of the Space Station. (11:00 AM, 31 Dec).Chris Hadfield / @Cmdr_Hadfield, TwitterBarrie, Ontario in snow - how it looked from ISS, today, 30 Dec at 12:40.Chris Hadfield / @Cmdr_Hadfield, TwitterThe Rockies are beautiful, and very much so from orbit - What an amazing view! (photo taken 30 Dec 12).Chris Hadfield / @Cmdr_Hadfield, TwitterLike a pointed toe into icy water - Long Point, Lake Winnipeg. Manitoba, from orbit. (30 Dec 12)Chris Hadfield / @Cmdr_Hadfield, TwitterThe Space Station followed this valley across the Prairie - 30 Dec 12. Recognize where it is?Chris Hadfield / @Cmdr_Hadfield, TwitterMontreal South Shore, in snow (and a trace of cloud) - how it looked today from ISS, 30 Dec at 12:40.Chris Hadfield / @Cmdr_Hadfield, TwitterCalgary emerging from the snow on New Year's Eve, with clouds beginning to roll in overhead.Chris Hadfield / @Cmdr_Hadfield, TwitterSackville New Brunswick, home of @MountAllison University - on the last day of 2012.Chris Hadfield / @Cmdr_Hadfield, TwitterUltrasound Lab - the rig we used to measure how Tom Marshburn's heart is changing and adapting without gravity, like rapid aging.Chris Hadfield / @Cmdr_Hadfield, TwitterSpace Experiment - close-up of colloid particles responding to magnetic field, making a fluid behave like a solid.Chris Hadfield / @Cmdr_Hadfield, TwitterMad Space Scientist - researching colloid behavior in the microgravity glovebox with a sensor bolted to my head.Tom Marshburn / @Cmdr_Hadfield, TwitterMt. Vesuvius, Italy, on New Year's Day, 2013. Looks a little like a remainder from earth's difficult puberty years. :)Chris Hadfield / @Cmdr_Hadfield, TwitterThe Alps are beautiful, even from orbit. Taken on the last day of 2012 from the International Space Station.Chris Hadfield / @Cmdr_Hadfield, TwitterAndros Island, a lesser populated island with some great diving. At the bottom center you can see the island's runway.Chris Hadfield / @Cmdr_Hadfield, TwitterAfter working hard on Station and sharing the experience as much as possible, it is nice to take a moment to relax. Tom Marshburn took this photo of Chris Hadfield playing guitar in the Space Station Cupola. Tom's a doctor, engineer & musician.Tom Marshburn / @Cmdr_Hadfield, TwitterShareAdjustCommentPrint xSharePhotos: Astronaut Chris Hadfield's Twitpics from space Email Twitter Facebook Pinterest Google Linkedin


text:
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30 thousands of directories to raise the TCI and PR of your site (most RUSSIAN AND WHITE)
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The possibility of buying on credit for three months for 7 cents.
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for a refund and negative reviews in the hope of a return, it just means that you
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WHITE Directory - a directory that place a direct link to your website
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Buy 1995 Johnson Evinrude "EO" 60 LV 90, 115, 150, 150C, 175 Service Manual, P/N 503151
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text:
09. Februar 2010 - After a 2009 of victories in rapid succession, the CRG Racing Team intends to keep its momentum throughout this new sporting season, too. Thanks to the new CRG factory, as well as to the new versions of Maxter engines recently homologated, a group of drivers more ambitious than ever and a carefully planned racing calendar, all the ingredients are there for a positive 2010...
Things will begin to get serious a few kilometres away from CRG's stronghold, in Lonato, with the opening of the international season at the South Garda Karting. The Winter Cup - already conquered several times by CRG's drivers - will celebrate its 15th edition from 19 to 21 February 2010 and all the "Men In Black" will be there.
"We really worked hard during the winter break to optimise the performance of the CRG range as much as possible" said the technical team on this season's debut. "Thanks to our new factory in Desenzano del Garda, we now have an infrastructure up to our ambitions. As for Maxter mechanics, they did a tremendous job with new engines. Nothing has been left to chance, either in Super KF, KF2 or KF3!"
After the Winter Cup, CRG will focus its racing efforts on the WSK. "Our team will be at the WSK Euro Series and then at the WSK World Series" declared Giancarlo Tinini, president of the CRG Group. "We have always believed in the success of this series, which fulfils the expectations of both teams and drivers, and what we see now is proving us right".
World Champion and winner of the WSK in 2009, Arnaud Kozlinski is ready for a new season with CRG-Maxter's colours, with Davide Forè on his side in Super KF. "In even years I always do great things and I expect a lot from this 2010 season", Fore' pointed out. "After the winter tests, I really feel confident".
In this category, the team will be completed by Eddy Tinini, who is making excellent progress, and by Felice Tiene, who has decided to return to CRG. Jonathan Thonon will race in Super KF in the Winter Cup, then the winner of the World Cup 2009 will enter the KZ1/KZ2 for the WSK. "Our goal is clear: victory!" the talented Belgian driver declared. As announced, CRG and Maxter will intensify their efforts in KF2 and KF3 with young drivers such as Martinez, Curia, Verstappen, Ziletti and Gerard.
CRG Racing Team 2010
Super KF: Arnaud Kozlinski (Fra), Davide Forè (Ita), Eddy Tinini (Ita), Felice Tiene (Ita)
KZ1: Jonathan Thonon (Bel)
KF2: Giovanni Martinez (Italy), Roberto Curia (Arg)
KF3: Max Verstappen (Bel), Mario Ziletti (Ita), Benjamin Gerard (Fra)


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Sumpter Township MI Area Primary Care Physician Providing Preventative Care for All Ages
For comprehensive primary care and preventative care services in the Sumpter Township MI area, visit the family physicians at Belleville Health Care today. At Belleville Health Care, PC, we are guided at all times by the values of compassion, trust and dignity. Our mission is to serve the people of this community through the provisions of optimal, high-quality medical care in a cost-effective health clinic.
No matter the age of our patients, our compassionate same day doctors are prepared to give quality care to each and every person. We treat infants, senior citizens and everyone in between! Given their vast medical backgrounds, our doctors and nurses are able to recognize, create a care plan and treat a variety of injuries, illnesses and health concerns. With our convenient location and hours, we are dedicated to providing the best, most comprehensive medical care possible.
Complete Health Care Services from Belleville's Leading Physicians
Dr. Murthy, President of Belleville Health Care, PC, is trained in various medical specialties such as primary care, preventive medicine, behavioral and addiction medicine. He holds two board certifications in urgent care medicine and addiction medicine/dual diagnosis.
Dr. Elliott Bettman, Co-Medical Director, is board certified in Internal
Medicine by the American Board of Internal Medicine.
Primary Care Physicians in the Sumpter Township MI Area Providing Preventative Care Services
Our health clinic is a quick stop for common preventative care, including physical exams, allergy testing, vaccines and more. It's important to visit the doctor more frequently than not, especially if you know something just doesn't feel right. However, with appointments being scheduled weeks into the future, getting the care you need hasn't always been easy. Luckily, Belleville Health Care, PC offers all of the family health care and preventative medicine services when you need it most.
We Offer the Following Preventive Care Services:
- Annual Physical Exams
- Blood Pressure Monitoring
- Diabetes Screening
- Blood Sugar Testing
- Sexually Transmitted Infection Testing
- Cholesterol Testing
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- Obesity Management
- Mammograms
- Psychiatric Assessments
- Tetanus Shots
- DOT Physical Exams
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- Lab Work
- EKGs
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- TB Skin Testing
- All Vaccines and Immunizations
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It's important to schedule preventative care visits at least once a year, but potentially more than that if you're at risk for certain diseases. This can depend on your age, gender, medical history and your family's medical history. If you had a doctor's visit three years ago and nothing since, there may be changes to your health that you may not know about. Frequent preventative care visits allow for early detection of chronic illnesses and as a result, treatment can be administered successfully.
Hear some of our patient reviews!
"Dr. Sanjay Murthy has been my doctor for a few years, he has been able to help me with everything from curing my insomnia, to helping me with weight loss, to reliving my joint pain. I highly recommend Dr. Sanjay Murthy." Andrew D.


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Company of Heroes Online Review
By MMOHut's Erhan Altay
Company of Heroes was originally released in 2006 and is one of the best rated and most innovative real-time strategy (RTS) games. The game's popularity led to two standalone expansions, and more recently, to a free-to-play version called Company of Heroes Online. The mechanics in Company of Heroes are very similar to a previous RTS called Warhammer 40k: Dawn of War. Both games were developed by Relic Entertainment, a studio owned by THQ, and stress fast-paced action over base and resource management.
From Korea, With Love
When Company of Heroes first came out in America, it was sold as a typical retail video game that had to be purchased at the store (or through digital download). When the game was released in Korea, it had to adopt the business model of the region. The Korean influence must have had an effect, as now Western gamers are getting the upgraded, free-to-play version called Company of Heroes Online. COHO is not a truncated or trial version of the original. Instead, it will contain all the gameplay features and even the single player campaign found in the original. Added on top of the old content is a new RPG influenced progression system. But, before experiencing any of that, players must get past the daunting 6.55 GB download. While THQ does publish another free-to-play game called Dragonica Online via their 'THQ Ice' brand, the two games don't seem to share login information. This means players will have to register a new account and log in using their email address.
Create a Commander
Each account has four character slots, which should be more than sufficient considering that there are only two playable factions; the Americans and Germans. Expansions to the original Company of Heroes eventually introduced additional factions (including the British), so the existence of multiple character slots may mean more factions will be offered at a later date. Perhaps through the item mall! All factions function similarly, but do have their own minor strengths and weaknesses. Germans have powerful armor units, but are more heavily reliant on fuel (one of the three resources). Players are given the opportunity to customize the appearance of their commander by selecting from a few hair and face styles. Commanders themselves won't be present in games, but will be displayed while in the lobby and other parts of the interface. Voice-acted prompts explain the interface and menu options to new players, eventually guiding them towards the training missions.
Fast Learner
Strategy games are not known for their ease of use, and unlike previous MMORTS games like Shattered Galaxy or BattleForge, Company of Heroes is a full fledged RTS with buildings to construct and multiple resources to juggle. The learning curve in COHO is steep compared to most other free games, but Relic did a great job cutting out the most arcane gameplay elements that traditionally went with the genre. A short series of training missions explains the game's basics including movement, special unit abilities, base construction, and resource management. The missions are entirely optional, but they each reward enough experience to level-up your commander and so are well worth doing. Players will also receive hero squads and items that buff their army by completing the training missions. These are two of the new components introduced in Company of Heroes Online. Each player has eight army item slots. These items provide bonuses to certain units, for example one of the items received early on provides additional armor to a certain type of tank. Hero units are assigned to building types pre-game and can be trained while in a game. Both army items and hero units have 'charges' which are exhausted with use. They won't disappear after their charges are depleted, but will require a recharge before being used again. Additionally, players can learn commander skills using ability points acquired by leveling up. There are a variety of commander abilities, each with its own tech tree. Some allow calling down artillery strikes on a targeted location, others provide passive bonuses. These new features add a whole layer of customization to the game that didn't exist in the original retail version.
Back to Normandy
World War 2 seems to be a popular setting for video games, but its usually in first-person shooters that gamers get to kill fascists. Company of Heroes allows players to experience the second world war from a more strategic angle. Rather than control a single soldier, players command squads and armored divisions. In most RTS games, players control each unit individually, but not in COHO. Infantry are trained and controlled as squads. There are several squad types available, and they can be equipped with different weapons like grenades, bazookas, machine guns, and so on. Tanks and other vehicles like halftracks are controlled individually, but maneuver more realistically than in, say, Starcraft. Terrain plays a major role as sandbags, craters, walls, bushes, and other objects provide cover bonuses to units nearby. Training units costs resources, and to generate those resources, players must capture munitions, fuel, and strategic points scattered across the map. Once captured, these points automatically generate resources: Manpower, Munitions, and Fuel. Since there are a finite number of resource points on a map, players who are aggressive will capture a greater portion of them and thus maintain an advantage. This set up discourages 'turtling', a common RTS strategy that leads to dragged out games. The drawback is that this system is not forgiving. The winning player is always at an advantage, forcing the loser to move fast or fall further behind.
Match Making Mode
Company of Heroes Online supports up to eight players per game in either 1v1, 2v2, 3v3, or 4v4 matches. Victory is achieved either by destroying all opposing buildings or reducing the enemy side's point counter to zero. The player or team who controls the majority of victory points on a map will cause the enemy's ticker to slowly decrease. COHO utilizes a match making system that pairs players with those near their skill level. Players can form teams of up to four and ask the system to match them with another team. While the new features help keep the game fresh, the interface feels archaic. It's functional, but why does it look like something out of 1996 rather than 2006? There's a shop where players can buy items which did not exist in the original version. There are a wide variety of goods available in the game's primary currency, called Supply. THQ Bucks are the premium currency, but despite the microtransaction model, skill will always trump money in an RTS like this. Company of Heroes was a great game even when it was $50 in the store. The chance to play it for free should not be passed up.
Final Verdict: Great
Company of Heroes Online is a the complete MMORTS package. It contains all the content of the award winning retail game, including the full length single player campaign. The ability to level-up your commander and customize your army adds motivation to play the multiplayer mode. The graphics still looks great, and make up for the slightly dated interface. Whether you're new to the RTS genre or returning veteran, Company of Heroes Online is worth checking out
Pros: +High production value. +Six playable divisions. +Customize unit upgrades, commander abilities, and more. +Fast-paced RTS gameplay.
Cons: -Steep learning curve. -Dated interface. -Only 2 playable factions.
What is your favorite MMO Genre?
City of Heroes
Rating: 8.0
Pixie Hollow
Star Wars The Old Republic
Battleground Europe: WWII Online
Rating: 7.5
Battle of the Immortals
Rating: 7.0
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text:
L9044/LV9044 Series - Privacy with Coin Turn Outside
L9044/LV9044 Series - Privacy with Coin Turn Outside
Privacy with Coin Turn Outside Function Description
Latchbolt retracted by knob/lever from either side unless outside is locked by inside thumbturn or outside coin turn. Operating inside knob/lever, closing door, rotating inside thumbturn or rotating outside cointurn unlocks outside knob/lever. Specify per L283-056 for Torx® screws. Available with rose trim only.
(Previously XL11-868)
All L9000 Series Mortice Locks (except electrified versions, non-keyed dummys and locks with the holdback function) are
CE marked (BS EN 12209: 2003) for use on steel doors.
Tested and assessed as suitable for use with metal based doorsets tested to the requirements of EN 1634-1:2008.
Assessment report WF No.335640 for up to 180 mins.
- Fully wrapped heavy gauge steel case protects against dooredge attacks
- All metal zinc dichromate plated working parts
- Inside lock case protects electronic components
- 2-piece anti-friction tongue reduces wear and tear
- Outside and inside trim thru-bolted together and through the door
- Break-away spindle prevents unsecured failures and provides easy spindle replacement
- Hub blocking plate protects lock against spindle manipulation
- Inside lever applied by screwless shank mounting – no exposed trim mount screws
- Floating mounting tabs automatically adjust to fit a beveled door edge
- Field reversible handing without opening lock case
- External spring cages allow for simple trim retrofit
- Lever rotation in both directions (up & down) for ease of use
- Independent lever rotation
The Vandlgard function allows the exterior lever to rotate freely down, while the door remains securely locked.
The L-Series Vandlgard option is ideal for areas subject to abuse or anywhere vandalism is likely to be present. Vandlgard prevents damage to internal lock components caused by excessive force from kicking, hitting or standing on the lever to gain access. It is easy to retrofit standard L-Series locks with Vandlgard using the Vandlgard Retrofit Kit. Use prefix LV in the product code.
* Addendum
44mm standard. 35mm to 64mm optional. Over 64mm door ranges vary by function.
Armour Front (Faceplate)
Lock Case
- Size - 113mm x 154mm x 25mm
- Spacing - knob or lever to cylinder, 98mm; knob or lever to thumbturn hub, 68mm
- Bolts - 25mm throw stainless steel deadbolt and 19mm throw stainless steel latch with anti-friction tongue.
ANSI curved lip strike 32mm x 124mm) x 30mm lip to centre with dust box standard.
Exposed Trim - 02A, 03A, 06A & LAT Design Levers on Round Rose (examples)
02A Lever on Round Rose 03A Lever on Round Rose
06A Lever on Round Rose LAT (Latitude) Lever on Round Rose
Levers: Forged brass or bronze and cast stainless steel.
Exposed Trim - 41A & 42A Design Knobs
41A Knob on Round Rose 42A Knob on Round Rose
Escutcheons (in lieu of Round Roses)
Example - 06L Lever on Escutcheon Plate
Trim Combinations
Thumbturns & Indicators
Available for rose and escutcheon trim. A larger 'disability' turn is available as an option to the standard thumbturn. Certain functions have occupancy indicator options and coin turn options.
Cylinders, Cams & Keys (not applicable to this function)
Cylinder Lengths & Specifications - 5 pin 'Classic' keyway cylinder with two keys standard
How to Specify or Order
Choose Lock Case required - example L9044 Privacy with Coin Turn Outside
Choose the Knob/Lever and Rose/Escutcheon Trim Designs and Finishes - example 03A 626 (Lever on Round Rose -
Satin Chrome)
Choose the Armour Front. - example 09-662 - 32mm width
Choose the Strike - example 10-072 32 mm x 124 mm x 30 mm
Choose the Cylinder (if required) - No Cylinder on Privacy with Coin Turn Outside Function
Finished Product -example L9040.03A.626
605 (US3) Bright Brass
606 (US4) Satin Brass
609 (US5) Antique Brass
612 (US10) Satin Bronze
613 (US10B) Oil Rubbed Bronze
619 (US15) Satin Nickel
625 (US26) Bright Chromium Plated
626 (US26D) Satin Chromium Plated
626AM Antimicrobial Coating on Satin Chrome
629 (US32) Bright Stainless Steel
630 (US32D) Satin Stainless Steel
630AM Antimicrobial Coating on Satin Stainless Steel
643e (U11) Aged Bronze


text:
Listen up boys. It's not that we girls don't want chocolate for Valentine's Day. It's just that we want good chocolate, and we want you to put some thought into it. A box of Milk Tray that you picked up from the garage down the road on your way home is not going to cut it.
A gorgeous little offering from Amelia Rope however is more than acceptable.
Not only is her chocolate super, super delicious but it looks the part too with each bar wrapped in pretty paper.
And this Valentine's Day Amelia has come up a very special romantic treat.
She said: "To celebrate St Valentine's Day this year I have decided to create something that your lucky Valentine can treasure and remember long after they have consumed the chocolate bar. I wanted it to be glittery and sparkly, romantic, simple with I hope sophistication.
"A glittery, glass covered red bead is tied using VV Rouleaux's double sided luxurious chocolate brown velvet ribbon to a dark brown card on which I will hand write, using a red glitter pen, your special message."
So you don't even have to go to the effort of picking up a pen to tell your sweetheart that you love them. There's really no excuse is there?
All you have to do is to choose which chocolate bar to send. Now I admit, this could be a bit tricky as there are some pretty tasty options like lemon and sea salt or smoked cashew – and that's after you've decided between dark or pale chocolate. Personally, I like the pale rose, (but that's partly because it comes wrapped in bright fuchsia foil and I'm a sucker for anything pink!) but you're on to a winner with pretty much anything you choose.
There's only 100 of these Valentine's specials available (which makes them even more special) so you'll have to be quick to snap up the last few.
Visit www.ameliarope.com to order.


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Margery B. Brown Memorial Media Fund Scholarship
Amount: $1,000
Due Date: Friday, February 22, 2019
Keep this scholarship funded for future generations.
The scholarship has been created to support the student-oriented teaching and production work in which Marge invested so much of her life at The Evergreen State College until her passing in 2006. Marge moved to Olympia in 1977 to attend The Evergreen State College. After graduating, she began her lifelong career as a faculty and staff member for the college. This scholarship will support a new or currently enrolled student interested in researching, producing and supporting socially relevant, experimental and critical media. Financial need will be considered.
- Letter of application no longer than two pages. Please speak to the following in your letter of application:
- Describe your interest in researching, producing and supporting socially relevant, experimental and critical media.
- What are you studying and why?
- How do you plan to use your degree after you finish at Evergreen?
- Include a statement related to your financial need.
- Two letters of recommendation supporting your application.
- FAFSA or WASFA (see How to Apply #4).


text:
The gang is getting back together for the next Star Wars movie. We already knew Harrison Ford was going to become an old Han Solo and now, Carrie Fisher is saying that she'll reprise her role as Princess Leia. Is this a good thing?
Carrie Fisher confirmed with the Palm Beach Illustrated that she'll be back as Princess Leia in Episode VII and explained where she thinks her character is now, saying:
Elderly. She's in an intergalactic old folks' home [laughs]. I just think she would be just like she was before, only slower and less inclined to be up for the big battle.
Fisher joked that she would still wear "the bagel buns and the bikini" in Episode VII which, well, probably wouldn't spawn a million Halloween costumes like it did after Return of the Jedi. Fisher had previously said she'd back in Episode VII last year but later claimed she was speaking 'tongue in cheek'. This time feels a little more solid. So if Princess Leia is in the fold now and with Han Solo already committed, does that mean old man Luke isn't so far behind?


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30 in 30: Young Panthers look to re-establish successby Mike Battaglino
You'll have to excuse the Florida Panthers if they seem especially eager for the 2013-14 season to begin.
The sooner they can erase the bad taste of 2012-13, the better.
"I'm excited about our future. The past is the past," general manager Dale Tallon said almost immediately after last season ended. "What happened should be a lesson to everyone that they have to be prepared and ready to play, and they have to compete for jobs, and no one is given a spot here."
The Panthers went from division champion to last in the NHL, a dive caused in part by injuries to almost all of their top players and deficiencies in their conditioning and consistency of effort.
"[We were] blindsided by it all, unexpected obviously, after what happened [in 2011-12]," Tallon told the Panthers website. "The NHL's a tough league, and if you're not prepared and not ready to play and you're not at your best every night, you're not going to win. And we were not at our best on a lot of the nights.
"There were a lot of reasons for it, but if it's going to happen it might as well happen in a shortened season, I guess."
Then, to add insults to the injuries, the Panthers lost the NHL Draft Lottery and saw their franchise leader in games played leave as a free agent.
So when the puck drops Oct. 3, they could be without two of their better players, this after losing an incredible 320-man games over a 48-game schedule, along with 33 on the scoreboard (15-27-6).
Seeking any sunshine from their sorry state of affairs, Florida turned to its fruitful crop of top-level prospects, getting them NHL exposure earlier than planned.
"Because of the injuries and the tough season we had, some of our young guys gained some invaluable experience as far as giving them a leg up on the competition moving forward," Tallon said.
The Panthers are hopeful their fountain of youth can help them in their transfer from the friendly but now-extinct Southeast Division to the realigned Atlantic, where some Original Six NHL heavyweights (Boston Bruins, Detroit Red Wings, Montreal Canadiens) will extend a chilly greeting.
Goaltender Jacob Markstrom, 23, is ascending to the No. 1 job, with free agent Jose Theodore unlikely to return. The top-four defensemen will include 21-year-old Erik Gudbranson and 22-year-old Dmitry Kulikov, with 21-year-old Alex Petrovic likely to earn a roster spot.
Forwards Nick Bjugstad (21), Quinton Howden (21) and Drew Shore (22), who each made his NHL debut last season, could be part of the top six, where 20-year-old Calder Trophy winner Jonathan Huberdeau already is.
Add to that mix 20-year-old Vincent Trocheck, the Ontario Hockey League's Most Outstanding Player, and 17-year-old Aleksander Barkov, the No. 2 pick in the 2013 NHL Draft.
"I don't care about age," Tallon said. "I don't care about anything but ability and performance; [that's what] dictates who plays and who doesn't."
Injuries dictate that too. Seventeen Panthers were sidelined at one point last season, including captain Ed Jovanovski (hip) and top-line forward Kris Versteeg (knee). Those two may not be recovered by opening night.
Huberdeau, coming off hip labrum surgery himself, is the face of the franchise with forward Stephen Weiss gone to the Red Wings. Weiss left not only as the Panthers' all-time leader in games played, but also first in assists, second in points and fourth in goals.
Veteran forwards Tomas Fleischmann, Tomas Kopecky and Shawn Matthias return after productively surviving last season; with Huberdeau, they combined for 55 of the Panthers' 109 goals.
Additions: RW Bobby Butler, RW Joey Crabb, C Scott Gomez, D Matt Gilroy, C Jon Matsumoto, D Mike Mottau, RW Steven Pinizzotto, C Jesse Winchester.
Subtractions: RW Jack Skille, D Tyson Strachan, C Stephen Weiss, D Nolan Yonkman.
UFAs: G Jose Theodore.
Promotion candidates: G Michael Houser, D Jonathan Racine, C Vincent Trocheck.
"We do feel we have the pieces here to get better," coach Kevin Dineen said. "… I do believe we have the personnel, from our goaltenders to our scoring players, to be a better hockey team than we were."The Panthers seemed like a team on the rise after winning the Southeast in 2011-12 with 94 points to make the Stanley Cup Playoffs for the first time since 2000. Their collection of high draft picks was lined up to foster improvement.
But Florida started last season 1-5-0 after winning the opener, and closed 2-7-0. The Panthers won three games in a row once, went 4-23-4 when allowing the first goal, and finished last in the League in goals-for and goals-against.
"I want to build on what we did [in 2011-12], not tear down everything because we had a 48-game season that wasn't a very effective one," Tallon said.
The GM helped construct the core of the two-time Stanley Cup winning Chicago Blackhawks, and he recalled difficult times there coming out of the 2004-05 lockout. Two playoff-free seasons allowed Tallon to draft Jonathan Toews in 2006 and Patrick Kane the following year.
Tallon expects a similar payoff in Florida, someday.
"There's a lot of failure in this business before you have success," he said. "You take the positives from it, you learn from it and you move on. If you don't move on, then you'll be out of work."For all 30 in 30 stories go to NHL.com/30in30stories and for the full 30 in 30 schedule visit NHL.com/30in30.


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Find thе Bеѕt Craft Beer Festivals аnd Beer Tasting Events in Nevada
Craft beer іѕ quickly bесоmіng thе toast оf thе alcoholic drinks scene wіth еvеrуоnе frоm seasoned beer aficionados tо thоѕе оf uѕ whо mіght hаvе originally preferred wine gеttіng involved.
Sо whаt іѕ Craft Beer?
Craft beer іѕ а chemical free, hand crafted alcoholic beverage thаt uѕеѕ natural ingredients іn іtѕ соurѕе оf production. Craft beer's popularity соuld bе attributed tо а move аwау frоm preservatives аnd mainstream brands іn favour оf mоrе artisan products thаt аrе brewed іn smaller batches.
Thіѕ nicely brewed beer hаѕ featured thе uѕе оf real ingredients which have bееn reported іn rесеnt times tо act аѕ biggest draws fоr іtѕ customers. This, in turn, hаѕ revolutionized іtѕ celebration іn ѕеvеrаl states іn thе United Stated оf America.
If уоu wоuld lіkе tо gеt а real feel оf such a festival in Nevada or nearby, thеn locate оnе close tо уоu thrоugh thе information shared below.
Great American Beer Festival (GABF), Denver Colorado
Thіѕ festival thаt wаѕ fіrѕt introduced іn 1982 wаѕ created bу thе nuclear engineer, Charlie Papazian іn Boulder, Colorado. іt іѕ uѕuаllу hosted іn а thrее day annual event bу thе Brewers Association durіng thе еnd оf September оr thе beginning оf October оf еvеrу year іn Denver, Colorado.
Thіѕ great event uѕuаllу brings visitors frоm аrоund thе world tо sample mоrе thаn 1,600 dіffеrеnt American beers wіth оvеr 100 beer judges frоm thе United States аnd аbrоаd participating іn thе evaluations оf оnе оr mоrе beer styles, аnd expected tо ultimately judge 2,300 beers entered bу mоrе thаn 450 domestic breweries.
Sіnсе іtѕ inception, participant's hаѕ аlwауѕ bееn mаdе tо run undеr thе Gold, silver аnd bronze medals categories іn thе 69 beer style.
Oregon Brewers Festival Portland, Ore
Thіѕ event thаt іѕ uѕuаllу observed durіng April 8th – 16th оf еvеrу year, wаѕ fіrѕt introduced іn 1988 аt Tom McCall Waterfront Park іn downtown Portland, Oregon. Itѕ uѕuаllу celebrates аll that's amazing аbоut ales, lagers, аnd craft beer.
Fоr аll day аnd night іn а week, thіѕ event gіvеѕ visitors thе opportunity tо taste amazing Colorado microbreweries аnd thеіr amazing beers асrоѕѕ downtown Denver. Frоm beer tastings, food pairings, cruiser crawls, rare releases, celebrity tappings, charity golf tournament, аnd vertical tastings аrе uѕuаllу thе event lined uр tо fill thіѕ ѕесоnd largest Great American Beer Festival.
The following video documents what happens during the 25th annual Oregon Brewers Festival in 2011, from set up to tear down and everything in-between. This is part one of a two-part film:
Thеrе аrе а lot оf events gоіng оn durіng іtѕ celebration week аnd уоu shouldn't mіѕѕ а single оnе оf it. іf уоu wоuld lіkе tо hаvе аn experience, thеn mаkе уоurѕеlf аvаіlаblе durіng thіѕ period.
This is part two of a two-part film:
Brewgrass Festival іn Asheville, NC
Thе Brewgrass Festival Founded іn 1996, іѕ referred tо аѕ thе Western North Carolina's original craft beer festival. North Carolina іѕ nоw home tо оvеr 100 breweries аnd brewpubs, аnd ѕіnсе thоѕе early days, Asheville hаѕ formed а burgeoning beer scene еvеn reigning аѕ thе Beer City USA fоr fоur years іn а row.
Brewgrass Festival's annual event hаѕ аlwауѕ showcased ѕоmе оf thе mоѕt in demand аnd exciting brewers іn thе region. Eасh year, оvеr 40 American breweries аrе uѕuаllу gathered tо showcase mоrе thаn 120 dіffеrеnt beers wіth great lineup оf national аnd regional bluegrass musicians tо add thе music flavor tо thіѕ remarkable event.
Amоng thіѕ list аlѕо includes Thе Bock Festival thаt іѕ uѕuаllу celebrated іn Nеw Ulm, Minnesota, durіng winter season оf еvеrу year. It's аlѕо knоwn tо uѕuаllу feature upto 120 family аnd friends оf thе brewery thаt mаdе thеіr wау оntо thе brewery grounds bасk іn February 28th, 1987.
This festival that started as an indoor event hаѕ ѕіnсе moved outdoors аѕ thе sizeable crowd nоw reaches 6,000 people from across the country. But whіlе thе size оf thе crowd hаѕ changed, ѕоmе thіngѕ hаvе not about this trailing event.
More Craft Beer Festivals in Nevada
If you are not living close to one of the above mentioned big beer festivals, you might want to consider one of the following resources to locate such an event in your vicinity:


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PriscoDigital Brings the "SPARK of Innovation" to Dscoop8 With Production Workflows and Latest HP Scitex Wide Format Technologies
By: Press Release | PriscoDigital
Newark, NJ, January 30, 2013 – At Dscoop8, February 21 – 24, Nashville, TN, for the second straight year, visitors can see a live demonstration of a complete, practical production workflow, from design-to-print-to-cut in adjoining Platinum Sponsor booths, Esko (#819) and PriscoDigital (#815). Join our staff of innovators as well as life-size replicas of Thomas Edison, Albert Einstein and Henry Ford that demonstrate how you can take your company in new directions.
Esko and PriscoDigital will create, print and finish 3D POP/POS displays as well as 2D samples. The digital inkjet workflow will feature an Esko i-cut Suite front-end workflow, preparing files for print while creating cutting instructions for the finishing system. PDF print files will travel to a Caldera RIP before rigid materials is printed on a hybrid UV HP Scitex FB 700 Printer. Printed sheets will be cut on an Esko Kongsberg XP 24 finishing system. The complete solution is perfect for anyone who needs to create printed material requiring multiple shapes and cutouts. The booth will also showcase roll to roll printing on a hybrid UV inkjet HP Scitex FB 500 printer and the complete Esko Suite 12 portfolio of packaging workflow solutions.
"Many companies forget that finishing is required to get a job out the door. Esko's finishing hardware and structural and graphic workflow software cover all aspects of a job. Print providers can expand capabilities to new applications making the world less rectangular with creative 3D packaging and display projects," remarked Eric A. Gutwillig, VP of Marketing for PriscoDigital. "Meanwhile, you still need a good digital press. What makes the FB series digital presses special is that as hybrid printers they are geared to anyone who needs to expand their capabilities and create a wide range of printed materials that require multiple shapes and cutouts – from packaging comps to displays," said Steve Zunde, President of PriscoDigital.
To make a visit to the Dscoop Solutions Showcase even more compelling, PriscoDigital has acquired an HP Scitex LX850 Latex roll-to-roll printing system and another HP Scitex FB700 running white ink applications. Both systems will be running live in the HP booth adjacent to PriscoDigital.
PriscoDigital is both an HP Scitex "Graphic Specialist" top tier distributor to the commercial markets as well as an Esko and Caldera sales partner. The company is looking forward to talking with Dscoop attendees about moving from analog, screen, offset and similar print technologies to wide format digital inkjet.
About Prisco and PriscoDigital (www.prisco.com)
Prisco is the world's leading manufacturer and distributor of offset pressroom chemistry, coatings, adhesives, blankets, supply items and process control equipment. Headquartered in Newark, NJ, Prisco has provided quality products and superior support services to customers for over a century. The PriscoDigital division focuses on providing complete turn-key wide format inkjet solutions based upon innovative HP Scitex Industrial Inkjet technologies and backed by the superior service, technical and customer support that Prisco has always been known for. PriscoDigital is the exclusive distributor of HP Scitex Industrial Wide Format Inkjet Systems to the commercial printing market segment.


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Trainee Recruitment Consultant - Sales People Wanted!
Trainee Recruitment Consultant - Sales People Wanted!
Do you have experience in an estate agency or sales based role?
Are you looking for a company where you are given extensive training and the opportunity to progress?
Are you competitive, outgoing and want a work environment which is in line with your personality?
Job Title: Trainee Recruitment Consultant - Estate Agency / Sales Experience
1sy Year OTE: £24,000 (basic salary) - £40,000+
2nd Year OTE: £40,000 - £70,000+
3rd Year OTE: £70,000 - £100,000+
(Attractive, uncapped Commission Structure)
Immediate start
Location: Central London - Covent Garden
My Client:
My client has experienced exceptional growth and offers an unbelievable opportunity for new candidates to enter as a trainee recruitment consultant and progress through the company. As this is a trainee level role, they will accept candidates with no experience in recruitment, but a desire to develop, learn and grow with the company. Experience as an estate agent is fondly considered by my client.
Role of a Trainee Recruitment Consultant:
- Managing the 360 recruitment cycle from start to finish
- Cold calling clients to sell recruitment services
- Sourcing the right candidates and organising interviews
- Meeting with high-end clients and pitching our services
- Negotiating fees and salaries
- Closing the deal / Placement for attractive commission bonuses!
Requirements to become a Trainee Recruitment Consultant:
- You must be career minded, hardworking and eager to learn.
- Previous sales or estate agency experience is preferred.
- Extremely financially driven and hungry for success.
- Outgoing, confident and sociable.
- Evidence of when you have performed well in a team such as playing sport at a high level
Benefits of becoming a Trainee Recruitment Consultant:
- Base salary of £24k with uncapped commission structure
- Company Lunch Clubs for top billers
- 3 Company Holidays a year - previous holidays include Las Vegas, Marbella and Ibiza
- Company sports teams including Football, Rugby 7s and Netball
- State of the art offices in Covent Garden
We are looking a number of money motivated individuals to join my client as a Trainee Recruitment Consultant in Covent Garden.
Apply now to be considered for this incredible, unrivalled opportunity!
Reference: 39159298
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Mountain Lake invaders fished out
Gill nets and a tippy rowboat are being used this month to pluck thousands of alien critters out of San Francisco's Mountain Lake as part of an innovative effort to resurrect the area's ecological history.
The Presidio Trust is trying to remove all of the invasive fish, turtles and other non-native species - some of them dumped from home aquariums - before dredging begins at Mountain Lake early next month.
The idea is to restore the historic body of water as close as possible to the way it was when American Indians roamed its banks. The plan by the trust, the National Park Service and the Golden Gate National Parks Conservancy is to remove toxic sludge, improve water quality and reintroduce native species to the 4-acre pond on the southern boundary of the Presidio.
"This is a huge opportunity for scientific research and education in an urban environment," said Jonathan Young, a San Francisco State University graduate student and biological researcher, after he rowed ashore the other day holding nets festooned with at least 500 squirming juvenile carp and large-mouth bass.
Young, who is spearheading the fish removal project for the trust, said the project is an experiment in urban landscape engineering the likes of which the city has never before seen.
Mountain Lake, which scientists say is 1,700 years old, is one of the few remaining natural lakes in San Francisco and was once a valuable source of drinking water for the Ohlone Indians and European settlers. It is now little more than a sludge-filled pool, festering with leeches, midge fly larvae and other unsavory creatures that like murky water.
Dredging sediment
The heavy lifting is scheduled to begin in early December, when 15,600 cubic yards of sediment will be dredged from the bottom of the lake. The project, which is expected to cost $9.5 million, including $5.5 million in mitigation from Caltrans, will increase the depth of the lake from 8 feet to 11 feet and remove mud that is saturated with lead that seeped in from adjacent Park Presidio Boulevard.
But the lake deepening and toxic sludge removal project is only part of the overall scheme, which was conceived in 2000. The Presidio Trust, with help from thousands of volunteers, has been planting native grasses and cutting groves of litter-prone eucalyptus trees in the area. They are planning to restore historic wetlands, plant native trees and place bio-swales - natural catch basins - next to the lake to redirect the silty runoff from surrounding neighborhoods and allow it to percolate into the ground. When the dredging is done early next summer, workers intend to reintroduce native aquatic plants, fish, turtles and mussels, but Young said all the existing species that replaced them must first be removed.
"The idea is that a healthy lake will have higher densities and greater abundance of invertebrates, and that will bring more birds and bats, but everything is riding on the removal of these fish," Young said.
Origins of problem
The trouble at Mountain Lake actually began in 1776 when the Spanish established el Presidio de San Francisco. The water at that time was crystal clear and clean enough to drink. It was home to western pond turtles, a fish called the three-spined stickleback, the red-legged frog, the chorus frog and a native mussel called the California floater, a filter feeder that improved water clarity, said Young, who has studied historical records, including sediment core samples going back 2,000 years.
The Spanish were the first to cut the native trees, burn wood next to the lake, plant nonnative tree species and graze cattle and sheep, all factors that altered lake habitat. The footprint of humanity only got bigger from there.
Turtles, frogs in soup
Many of the native frogs and turtles were cleaned out during the Gold Rush so restaurants could serve their tasty legs or put them in soup. Legend has it that turtle soup stopped being served in San Francisco during Prohibition because the recipe called for brandy.
In 1853, a 3,500-foot-long tunnel was built next to the lake in a much-touted but failed attempt to bring water to the developing city of San Francisco. A long wooden flume later brought water from the lake around Black Point (now Fort Mason) into the city.
Then, in 1897, the U.S. Army began siphoning water out of the lake to, among other things, irrigate its newly built golf course.
Originally 30 feet deep, the lake shrank by 40 percent when Park Presidio Boulevard was built through part of the lake bed in 1939. Lead from car emissions seeped into the water for decades until leaded gasoline was phased out beginning in the 1970s. The lead combined with zinc, petroleum hydrocarbons from motor oil and pesticides flowing in from the golf course to form a toxic stew.
Invasive species have repeatedly been added to the mix, first by the Army and then by locals setting their pets free. Crawdads, which eat the native aquatic vegetation, and large-mouth bass, which gobble virtually any animal they can swallow, were introduced. Gambusia, a mosquito-eating fish that also eats the eggs of native amphibians, were also added. In recent decades, goldfish, koi (otherwise known as carp), bullfrogs and pet turtles were plopped into the water, where they began to breed. In 1996, an alligator was found in the lake, creating a sensation until it was removed.
The natives have long since died out, poisoned by chemicals, eaten or pushed aside by introduced predators. The last record of a western pond turtle was in 1966.
The restoration plan began in earnest in July when more than 10,000 fish were removed. That included two or three dozen adult carp and bass ranging in size from 20 to 30 inches long, some weighing as much as 15 pounds. In addition, 42 non-native turtles were taken out, all of them pet store species like red-eared sliders, map turtles and painted turtles, Young said.
Relocating reptiles
All of the captured animals are taken to Sonoma County Reptile Rescue, which partners with breeders, pet stores, herpetological societies and local citizens to relocate more than 1,000 reptiles, amphibians and fish a year, ranging from large pythons to tiny newts.
"All the bass go to one pond and the carp to another pond," said Alan Wolf, the Reptile Rescue director, adding that 95 percent of the animals are placed in contained waterways on private property. "We have various people in the county with their own ponds where they keep different fish or turtles. The only thing we require is that any pond with a large number of turtles be fenced off so they can't get out."
Nevertheless, a handful of turtles and thousands of fish remain in Mountain Lake. The problem, Young said, is that a single female carp can produce 2 million eggs in a single season, making it difficult to capture them as fast as they reproduce.
"It's a challenge, definitely," Young said.
Young said other methods might have to be used, such as the introduction of koi herpes or genetically modified carp. Poison would be a last resort, he said, but that option will remain on the table for any stragglers after the dredging is completed.
Meanwhile, biologists are studying possible introductions of species like the San Francisco forktailed damselfly, the western toad and native San Francisco newts.
There is reason for optimism. Habitat restorations elsewhere in the Presidio have led to marked increases in the amount of wildlife, including thousands of baby western chorus frogs earlier this year in a restored seasonal pond near Mountain Lake. The native tree frogs had disappeared from the Presidio many years ago and now appear to be making a comeback.
"This natural area has huge potential to inspire the next generation to really try to protect and conserve and become aware of the biodiversity and our connection to it," Young said. "Urban ecology has been an up-and-coming new field, and with this project, the public is starting to become aware of the impacts of urbanization and the plight of these species."
Need a new home for your pet fish or reptile?
Call Sonoma County Reptile Rescue at (707) 829-8152, or e-mail email@example.com.
Peter Fimrite is a San Francisco Chronicle staff writer. E-mail: firstname.lastname@example.com Twitter: @pfimrite


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Download the latest version for PC, OSX absolutely FREE! Join the Toribash community today and start to work your way up the ranks.
Toribash has been lucky enough to win some excellent awards. Download the game for free and judge for yourself!


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Feeling the Buzz
I'm sitting here patiently waiting for Illinois and Purdue to finish their overtime game because Indiana plays Minnesota next. I really don't care who wins so we'll update the blog.
Saturday is the annual Family Day Open House and little by little the ballpark is starting to look ready for Opening Day. In the last couple of days there has been a different pace in the Front Office. Shipments are arriving at the dock at the back of the park, ticket windows are being wiped crystal clear at the front and from top to bottom the park is getting organized. While many of the areas considered 'behind the scenes' are functional for fans and the team if they arrived today some are not. I'll talk more about ballpark preparation closer to Opening Day but for now I'll focus on my Open House top picks.
- Clubhouse: The home away for home for the Bisons players during the season and a rare opportunity for you to take a peek at Torey Lovello's office among the other things that make this one of the most comfortable clubhouses in baseball.
- Batting Cages: On the lower level just outside the Bisons Clubhouse are two full length batting cages. This past year they've been used A LOT by high school kids and various camps. Here's your chance to step in and take a few hacks.
- Press Box: One of the best views to look at the park no matter what time of year. A large collection of Bisons memorabilia will be laid out on press row and you'll have a chance to see the main production rooms that produce all the sounds you hear while you're at the game. I tested the radio equipment earlier in the week and left everything set up so you can see how it looks for the broadcast. If the team was in town, all Duke and I would have to do is sit down and bring you the game.
- Ticket Windows: Why is this so cool? Because when you hear the words, "next in line please," you're just minutes away from holding your tickets to another great night out with your friends or the family.
In case you were wondering, Illinois advances in the Big Ten Tournament after Purdue shoots 0-10 in the extra period, finally time to watch the Hoosiers.


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Stars are usually full of stories of on-set misery for their art, but Megan Fox insists she loved wearing her corset on "Jonah Hex."
Forget how painful it looks to a modern audience.
"I loved the corset," Fox said at the press day for the movie. "People thought I was in pain or hurting or something was wrong with me because my waist is so small. But I enjoyed it."
"And I wish they would come back in style."
Fox was kidding about that. But she rocks the corset in "Hex" which the filmmakers insist was accurate apparel for that era.
Director Jimmy Hayward said the look was "pretty typical. We had a lot of photographic research."
But there was nothing typical about the look with Megan Fox in it. The very mention of it will certainly bring a good portion of comic book geeks out of their locked bedrooms to the movie theater.
So while Josh Brolin was groaning through three hours of make-up to disfigure his face, Fox was lacing up the corset and apparently happy as lark.
That said, being small boned had its disadvantages for period items. While Fox slipped perfectly into the corset, she had trouble handling the Western-style guns.
"It was difficult for me to shoot the old-style gunslinger guns," she confessed. "I have tiny little hands and they are really large and really heavy."
"Just the physicality of actually having to pull that off was really difficult."


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Franklin Morales helps Rockies beat Padres 3-1
SAN DIEGO (AP) — The Colorado Rockies got another unexpected outing from a starting pitcher who had been relegated to the bullpen.
Franklin Morales followed a good start by Jorge De La Rosa with one of his own, helping the Rockies beat the San Diego Padres 3-1 Thursday.
Colorado used Wilin Rosario's tiebreaking groundout in a three-run seventh to overcome Ian Kennedy, who pitched a one-hit shutout through the sixth.
Morales (1-1) allowed one run and four hits in six innings with five strikeouts and a walk. Morales made his second career start against the Padres — and first since allowing one hit in six shutout innings at San Diego on Sept. 21, 2007.
"That was crucial for him to get through the sixth," Colorado manager Walt Weiss said. "He stepped up. It's tough to go back and forth between the `pen and starting."
Injuries to Tyler Chatwood and Brett Anderson, have forced the Rockies to start Morales and De La Rosa, who both were sent to the bullpen earlier after ineffective starts.
De La Rosa was the loser in Wednesday night's 4-2 defeat, but threw well; he allowed three runs — two earned — and seven hits in six innings.
"I have a job to do," Morales said. "I don't worry about where I pitch. I just want to do whatever I can to help my team win."
Morales allowed a solo homer to Xavier Nady leading off the fourth, a drive off the facing of the second deck in left field.
That stood until the seventh. Corey Dickerson reached on a one-out double, Troy Tulowitzki walked and Justin Morneau lined a ball to right field. Chris Denorfia broke in, then retreated as the ball went his head for an RBI double.
"Morneau hit that ball pretty hard and they got a couple guys on," Kennedy said. "I was trying to get a double play in that situation."
Rosario grounded out to shortstop as Tulowitzki scored for a 2-1 lead, and Nolan Arenado followed with a run-scoring single.
"Kennedy was tough, pounding the ball down, hitting the corners," Morneau said. "But when he made mistakes, we took advantage, and we had some good at-bats in the seventh."
LaTroy Hawkins pitched the ninth to remain perfect in four save chances, finishing just the fourth win for the Rockies in 11 road games this season.
Kennedy retired his first 12 batters before walking Tulowitzki leading off the fifth. He didn't allow a hit until Arenado's leadoff double in the sixth.
"It's tough. I threw well for the first six innings," Kennedy said. "I felt like I was executing my pitches. I was getting ahead of guys and when I didn't start off with strike one I felt like I was getting back to even in the count and it was just nice to execute like that."
NOTES: Nady's homer was his third of the season and San Diego's eighth, the lowest total in the NL. … San Diego's Everth Cabrera extended his hitting streak to nine games with a second-inning double. … Padres 3B Chase Headley was held out of the starting lineup for a second consecutive game with a strained right biceps. Headley had a pinch-single in the eighth. … Rockies RF Michael Cuddyer left in the seventh with a right hamstring cramp. … Longtime Rockies 1B Todd Helton is scheduled to be inducted into the Colorado Sports Hall of Fame Thursday night at Sports Authority Field in Denver. … Padres 1B Yonder Alonso entered in the ninth inning and played third base for the third time in his big league career. … Anderson had surgery on Thursday to have pins inserted into his fractured left index finger. The pins are expected to remain for six weeks. … The Rockies open a three-game set at home Friday night against Philadelphia, which sends RHP Jonathan Pettibone (0-0) against RHP Tyler Chatwood (0-0). … Giants RHP Matt Cain (0-2) opposes Padres RHP Tyson Ross (1-2) on Friday night.


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Export 8 results:Author Title [ Type] Year
Filters: Author is Cole, William S. [Clear All Filters]
Journal Article
Conductance spectroscopy of nontopological-topological superconductor junctions, , PHYSICAL REVIEW B, 95, 020501 (2017)
Effects of large induced superconducting gap on semiconductor Majorana nanowires, , PHYSICAL REVIEW B, 92 (2015)
Induced spectral gap and pairing correlations from superconducting proximity effect, , PHYSICAL REVIEW B, 94 (2016)
Ising quantum criticality in Majorana nanowires, , PHYSICAL REVIEW B, 96 (2017)
Proximity effect and Majorana bound states in clean semiconductor nanowires coupled to disordered superconductors, , PHYSICAL REVIEW B, 94, 140505 (2016)
Striped ferronematic ground states in a spin-orbit-coupled $S=1$ Bose gas, , Phys. Rev. A, 91, 023608 (2015)
Strong-coupling phases of the spin-orbit-coupled spin-1 Bose-Hubbard chain: Odd-integer Mott lobes and helical magnetic phases, , PHYSICAL REVIEW A, 96 (2017)
Transport in superconductor-normal metal-superconductor tunneling structures: Spinful p-wave and spin-orbit-coupled topological wires, , PHYSICAL REVIEW B, 95, 174515 (2017)