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|By Jason Bloomberg
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|April 14, 2018 01:45 PM EDT
Seven Criteria for Evaluating a Blockchain Business
The insane world of cryptocurrency may be chock full of schemers, scammers, and sharks, but there is more to the world of blockchain than crypto.
In fact, the blockchain story is bifurcating, with crypto and all its craziness on one side, and enterprise blockchain on the other.
While it may be fun to poke our stick at the former, Intellyx's focus is on enterprise digital transformation – which means that bona fide blockchain-based business models are a key part of this ongoing story of disruption.
Regardless, we receive numerous pitches every day from all manner of blockchain-based companies, from the most serious to the silliest.
When we set up a briefing with one of them, we need to quickly determine which camp it belongs in: serious enterprise play or crazy crypto?
We're not alone. If you're interested in this space, regardless of whether you're an investor, participant, or potential customer, you'll need to separate the wheat from the chaff yourself.
Here, then, are our seven criteria for evaluating such companies – criteria you may find useful as you navigate the turbulent waters of blockchain.
1. Is there a well-defined business problem?
If a company is saying something like 'blockchain is cool. What can we do with it?' then you know they're already on the wrong track. The first step for any new business idea, blockchain or no, is to identify a problem – in particular one people will pay you to solve.
It's surprising how many blockchain business ideas fail this most important first step. Don't waste your time on them.
2. Is a blockchain-based approach the best or only way to solve the problem?
Just because a company might be able to use blockchain to address the business problem from #1, that doesn't mean that blockchain is the best approach. After all, blockchain is still largely on the drawing board, and is potentially only well-suited for certain problems involving multi-party transactions.
There are reasons why so many Internet-based business have centralized transaction processing: it works, we know how to scale it, and it's a money-maker for the processor. You'd better have a very good reason for walking away from such benefits.
3. How will the company get over the tipping point?
Blockchain at its core is a decentralized, distributed ledger system. To make any blockchain-based business work, therefore, there must be a sufficient number of participants to drive adequate value for other participants to join.
In other words, blockchain is a classic example of Metcalfe's Law: the value of the network goes up as the number of participants grows.
The problem with Metcalfe's Law, of course, is the tipping point problem. If there aren't enough participants, then no one else wants to join. As a result, any blockchain business must have a plan for attracting such participation ahead of this tipping point.
Going viral is one approach – but if a company is betting on virality, run in the other direction. There's no good way to plan for virality, and it's virtually impossible to reproduce.
What's left? Spending money. Lots of it. And regardless of how deep the pockets, success is still far from guaranteed.
4. Who are the 'miners' and how will they be compensated?
In the crypto world, the transaction processors who run the distributed nodes are called miners, because Bitcoin and most other cryptocurrencies reward them for processing such transactions.
In the enterprise blockchain world, in contrast, transaction processors may or may not receive such rewards directly from the blockchain infrastructure itself. The question then arises: who will execute the blockchain transactions, and what's in it for them?
Remember, blockchain business models are almost always decentralized, which means that such miners must step up to the plate on their own – so there had better be a plan for attracting and compensating them.
5. Is there a rational token model?
Every blockchain business essentially creates its own token economy. Such tokens may have true monetary value – in other words, cryptocurrency. Other tokens have utility, meaning that they are basically just coupons a holder of the token can exchange for a product or service.
Utility tokens would typically have monetary value as well, just as grocery coupons do – but regulations in the US and elsewhere treat them differently. In any case, most enterprise blockchain businesses appear to be leaning toward utility tokens.
You have to ask yourself, therefore, how such tokens will actually work once the business is up and running. If someone is supposed to trade a token for a product or service, then will the recipient of that token value it sufficiently to actually provide that product or service?
Do they have monetary value, and if so, how would people cash them in? Are they subject to the speculation that has driven such obscene volatility in the crypto markets, and if so, will such volatility reduce the tokens' utility?
There are bound to be plenty more questions, but this is a start. See if you can think of more.
6. How will the company make money long-term?
Let's say the company with the brilliant blockchain business idea is able to pass the tipping point, and now there are plenty of 'buyers' and 'sellers' willing to exchange tokens for goods or services, and plenty of miners willing to conduct the transactions.
So far, so good. Now ask yourself: how will the original company make money? Remember, the entire kit and caboodle is decentralized, so no one is in charge, including the company that got the thing off the ground.
Will they be happy simply being one of the miners? Do they consider themselves a software company, charging participants in this new blockchain economy a licensing or subscription fee for using their software? Given that much of the blockchain software in the works today is open source, then selling software won't do. So what's left?
Today, many such companies are focusing on their initial coin offerings (ICOs), also known as token generation events (TGEs). The idea behind an ICO is to create a large number of tokens out of thin air and sell them to speculators and future users of such tokens in order to fund the startup phase.
Sure, this ICO puts money in the coffers of the company to start, but then what? There has to be a business model (i.e., a way to make money) beyond the ICO itself.
You know what I call a company without a business model? A hobby. And what do I call a company with a lucrative ICO and no business model? A scam.
7. How will distributed consensus work without becoming centralized?
The company that founded this new blockchain ecosystem cannot remain in charge of it for fear of defeating the entire purpose of a decentralized business model in the first place.
Who, then, runs the show? If, say, someone discovers a problem with the underlying technology, who makes the decision how to fix it?
The answer: a consensus of the participants. Consensus, however, is far trickier than you might think.
First of all, who gets a vote? Just the miners? Or do all the 'buyers' and 'sellers' that participate get a say? And if they do, does their vote count for as much as the miners' votes? Do all miners get the same vote?
Even if you solve those problems, how many votes are necessary to make a decision? Some systems have a 'majority rules' approach – but such an approach leads to the '51% problem,' where the majority can make any changes they like, regardless of the protestations of the minority or the participants without a vote, for that matter.
Another popular system is the 'unanimous' approach. No voters are left in the cold with this approach to be sure, but now everyone has veto power. What if there's one bad apple in the bunch? That party can now veto all decisions, including the one to vote them out of the gang.
What, then, is the best approach to consensus? The answer: nobody knows. This entire area is so new – not just the technology, but the business models as well – that there are numerous unknowns.
The Intellyx Take
Plenty of blockchain business have figured out #1 and #2, and a few have reasonably good, but still risky plans for getting around #3, the tipping point.
But #4 – #7? Nobody really knows what will work long-term. The issues with Bitcoin mining have illustrated that its approach isn't going to work for enterprise blockchain businesses (and I predict it won't keep working for crypto much longer, either). There are plenty of alternatives out there, but none of them have been through any kind of trial by fire.
As for tokens? Even Monopoly money is good for playing Monopoly, which tokens aren't.
The consensus challenge, however, is perhaps the knottiest of all, as there's an easy downhill path to centralization for all these businesses. Centralized decision making is just so much easier.
And regardless of which consensus model an ecosystem picks, they can always simply vote to put someone in charge and be done with it.
So, skeptics we are and shall remain. Will Intellyx continue to cover the enterprise blockchain space, in spite of our skepticism? Absolutely.
Are we ready to point to any business idea as a leader? Not even close. We're hardly out of the starting gate.
Copyright © Intellyx LLC. Intellyx publishes the Agile Digital Transformation Roadmap poster, advises companies on their digital transformation initiatives, and helps vendors communicate their agility stories. As of the time of writing, none of the organizations mentioned in this article are Intellyx customers. The author does not own any cryptocurrency, nor does he intend to own any in the future. Image credit: public domain.
DXWorldEXPO LLC, the producer of the world's most influential technology conferences and trade shows has announced the conference tracks for CloudEXPO | DXWorldEXPO 2018 New York.
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Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud strategy. Meanwhile, 94% of enterprises are using some form of XaaS - software, platform, and infrastructure as a service.
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Companies are each developing their unique mix of cloud technologies and services, forming multi-cloud and hybrid cloud architectures and deployments across all major industries. Cloud-driven thinking has become the norm in financial services, manufacturing, telco, healthcare, transportation, energy, media, entertainment, retail and other consumer industries, and the public sector.
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- The Top 150 Players in Cloud Computing
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Session #18
December 17, 2015
Christmas. It has arrived and in full force this year, earlier than ever. Since leaving the Jehovah's Witnesses back in 2008, I've only really experienced this holiday a few times in it's flavour and colours. The last few years were celebrated with minimal flair and not really much enthusiasm. I could not get into it … More Session #18

subset: commoncrawl


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Here's a trailer to get you in the mood for the kickyball, plus, you know, some amazing jobs in Berlin…
Country Manager UK (m/f)
barcoo links products in stores with independent consumer information. Your mobile phone becomes a barcode scanner and shows you everything you need to save money, take care of your health and our environment: price comparison, test reports, health, green and sustainability information. See us in action on flickr.
With currently more than six million downloads, barcoo is one of the most successful apps in Europe. Behind this success stands checkitmobile GmbH, a start-up in Berlin-Kreuzberg.
About the role
You are responsible for the UK expansion of barcoo. At the heart of this position is:
- Business Development: identifying new content sources, initiate and negotiate relations with possible partners
- Product Management: coming up with (content-) features that might help make barcoo more useful and valuable for UK consumers
- Content Marketing: identifying possible PR stories and coordinating our UK PR efforts.
- You will be working in our Berlin office and travelling to London on demand.
About you
- UK native
- Based in Berlin or willing to move to Berlin
- Willing to take on responsibility for personnel in a growing start-up
- Professional experience preferably in the internet industry
- Good technical understanding of mobile and internet technologies
- Experience in Product Management desirable
- Affinity to sustainable lifestyle
- Knowledge and experience in developing business relationships
- Sound understanding of the British consumer market and society
- Presentational skills and outgoing personality
About the offer
- The opportunity to create a successful mobile service in UK based on barcoo's success in Germany. Millions of consumers use our app to help with their next purchase. Work with people who passionately develop and improve the barcoo project.
- A growing start-up gives you many opportunities for personal development, and to take responsibilities. We offer not only a great working environment in a successful startup, but also an exciting location in the heart of Berlin as well as travels to London and the opportunity to progress with us in a rapidly evolving industry: the mobile Internet.
Atlantic Ventures is looking for an Entrepreneur-in-Residence and CEO
About us
Atlantic Ventures is an entrepreneurial ventures firm focused on creating and supporting innovative ventures. Led by Christophe Maire, who co-founded Gate5, Plazes and txtr and has 15 years of experience in company building and investing, we have been involved in numerous success stories such as SoundCloud, Amen, Gidsy and Monoqi. As we prepare to start our next venture, we want you to join our team as Entrepreneur-in-Residence and CEO.
About you
- Completed studies in business or another relevant field, ideally with a Masters degree from a renowned university or an MBA from a top-tier business school
- Several years of work experience in a challenging, fast-paced environment (eg management consulting, eCommerce or other startup, etc)
- Advanced interpersonal and leadership skills – ability to build, motivate, structure and grow a functionally diverse team
- Strong analytical skills – ability to set up efficient business processes and develop an organization from scratch
- Keen and able to cover a broad range of topics from consumer branding and marketing to operations, IT and finance
- Passionate about living the lifestyle of an entrepreneur – pragmatic, bias for action and comfortable with ambiguity
- Excellent German and English skills
About the offer
- The chance to run a disruptive internet company within the next three months
- Access to a broad and strong network within the internet industry
- Adequate compensation plus attractive equity stake
- Location: Berlin-Mitte
- Start: Immediately
How to apply
Send your CV and a few lines on why you're the right person for this position to firstname.lastname@example.com
GetYourGuide is looking for a Product & Sales Manager Internship
GetYourGuide.com, the online booking website for tours and activities, and one of the fastest-growing startups in travel (from bus sightseeing in London to shark diving in Cape Town) is looking for a smart, forward-thinking problem solver to join their Berlin team. In the paid, three-month internship, you'd have the chance to convince them of a full-time position and you also get pizza every Friday.
About the post
You'd be in charge of establishing successful relationships with key tour and activity suppliers from around the world via phone and email, supporting and educating suppliers about how to use platform, and attending travel expos and workshops to meet with people active in the tourism industry.
About you
An internet-savvy and travel enthusiast who's approachable, confident, and (ideally) well-travelled and experienced in client-interaction such as customer service.
How to apply
If you're interested, email your CV as well as a letter of motivation (describing your sales personality) to email@example.com with the subject line "VV Product Management".
BGPM needs a German and English-speaking communication strategist
About the post
This American-gone-German company is on the hunt for a Communication strategist with a particular talent for social media. In the position, you'll need to deliver user-focused campaigns and coordinate strategies with suppliers and the HQ communications department.
About you
You will have communications experience, particularly in internet and mobile technologies, connections to key media and other influencers, and fluency in German and English. If interested, send your CV, photo and salary expectation to email@example.com.
Employers – get the best international candidates for your company
If you're interested in posting your latest job listings here please send an email to firstname.lastname@example.com


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I have driven by this place a million times and read all the reviews. After eating here, I now realized why I did not stop in before.
I'll let you know that I do not base my opinions on the exterior and interior physical plant of an establishment. I have had many a great dining experiences in places that looks like it should be torn down. However, this place takes the cream. For a place with the title of "14 Annual Orlando Sentinel Foodie Awards Critic's Choice for Best Wings" come on! A worn interior is one thing but a sticky table and messy dining room leaves a lot to be desired.
There are many choice of sauces and various combinations of wings. The menu has some sandwiches and what not. But I was there for these famous wings of 20 years. Or is it the chicken is 20 years old? The wings themselves are rather small and tiny, non breaded and deep fried, then tossed in sauce. Rock hard skin, flecks of flesh and bone are not really what I expected. Wasn't this place voted the "Best Wings" with raging reviews all across the board. Oh my, am I going to be the only one who does not think this wing deserves any title at all? We had the Honey BBQ sauce, which could have been off the Walmart shelf and this famously over emphasized Lemon Pepper sauce that everyone including the server is bragging about. Lemon Pepper? Where was the Lemon, where was the Pepper? More like tiny wings flapping around in a pound of butter. The rack of ribs was fall off the bone tender, but the excitement stopped there. Nothing further.
I was disappointed. Maybe my expectations were too high, being voted "Best Wings by the Orlando Sentinel" and all. Or was it that I had the Wally Wings and Teak Neighborhood Grill experience to gauge from? Whichever, I'll just keep driving by and avoid any conversations about this place.


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The form below is for non-emergency maintenance requests. For maintenance that requires more immediate attention (especially after-hours), please call the office at (770) 502-8582 and follow the prompts to put in the work order. In the event of a life-threatening emergency, call 911.
Please specify in the detailed description if maintenance is authorized to enter your apartment home after knocking between 9:00 am and 5:00 pm on weekdays. If you do not authorize maintenance to enter your apartment home, please call the office for scheduling arrangements. Thank you!


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The Quench Weird Water News recaps the week's top 5 weirdest water-related news stories. Come back each Friday for the latest stories!
- This Golden Retriever is going green! A pet owner in China has trained his Golden Retriever to fetch water bottles from the eastern Jiangsu province's polluted rivers!
- Want to stay cool and have a good time at your next BBQ? Dogfish Head Craft Brewery has created a beer that apparently quenches your thirst and does not dehydrate you.
- This might be the bravest dog you've ever seen! A video has gone viral of a dog jumping into water to rescue a drowning young deer!
- Mother Nature just pulled off the worst bank robbery in history! The Federal Reserve will have to replace a lot of money because flooding has destroyed all of the cash in a vault of a southeastern Wisconsin bank.
- Looks like SpongeBob is vacationing in France! Hundreds of thousands of mysterious yellow sponge-like balls have washed up on beaches in northern France and authorities aren't exactly sure of what they are!


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Professional Service & Parts Manuals
OlderManuals offers downloadable service manuals, parts manuals and operator's manuals for your older tractor, backhoe, excavator, crawler, loader, skid steer, engine and more. Whether you need repair instructions, part numbers or operating and maintenance information, our professionally reproduced manuals are the best tool for the job. Our manuals are available in a convenient downloadable PDF format. We add new manuals on a regular basis, so if you can't find what you need, please contact us.
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Our manuals are better than the originals. With a downloadable PDF format, you get a professional manual – the same one dealer mechanics use – that won't be dirtied or torn in the shop. Print from it as many times as needed.
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Our website uses encryption at checkout to securely transmit payment information. We also accept PayPal payments. Security is our priority.
You can expect prompt, courteous responses to any questions you may have, before and after your purchase.


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The Oprah Winfrey Channel on SiriusXM satellite radio has vanished with no explanation, other than a programming announcement that reads: "This channel is no longer available."
SiriusXM signed the media mogul and former talk show host to a high-profile deal in 2006, around the same time the company placed shock jock Howard Stern onto its subscription only platform.
"The Oprah Channel," was originally launched as Oprah and Friends, where Winfrey herself was slated to broadcast a live weekly show in which she would interview with friends and audience members, while the rest of the week would spotlight programming from other people close to her inner circle, such as Gayle King.
Those plans reportedly fell through after Winfrey launched her TV network OWN.
Neither party has made any public statements regarding the channel's inexplicable absence from the SiriusXM line-up, however Tom Taylor Now has reported that the show's second contract has expired.
Oprah's original contract with the company was reportedly worth $18 million over three years, while the second deal is believed to have been for less.


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Comparative Study of Ologen Collagen Matrix Versus Mitomycin-C in Glaucoma Filtering Surgery (MCToCM)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01440751
Recruitment Status : Completed
First Posted : September 27, 2011
Last Update Posted : November 1, 2017
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Device: Use of ologen Collagen Matrix in trabeculectomy (ologen) Drug: Use of Mitomycin-C (MMC) in trabeculectomy
|Phase 4
"ologen ® CM" is a biodegradable collagen matrix. To prevent episcleral fibrosis and subconjunctival scarring thay may result in the surgical failure in trabeculectomy, its sporous matrix modulates the migrations and proliferations of fibroblasts to create a vascular and long-lasting bleb without the adverse effects, such as avascular thin bleb wall, bleb leak, hypotony, and inflammations, potentially caused by the regeneration suppression effects upon the use of cytotoxic agents as anti-fibrotic agents, such as MMC (Mitomycin-C)in the study.
Results of ologen CM studies have been published at conferences and published in peer-reviewed journals; ologen CM is approved in Europe as an aid for tissue repair, and by the FDA in the US as an adjunct in wound management(K080868). In general, over 6,000 ologen CM have been implanted worldwide during the past two years with good results and excellent safety profile.
The clinical trial is a phase-IV post-marketing FDA approved device study designed as open-label, randomised, parallel, and comparative. 128 patients at 8 sites are anticipated to be recruited according to the enrollment criteria, while randomisation will be assigned by a sealed envelope system after the patient has signed consent. Trabeculectomy is performed thereafter with either MMC or ologen CM applications as described in the protocol with postoperative parameters to be measured and analysed with non-parametric tests(Chi-square, Fisher's exact, Wilcoxon, and Mann-Whitney tests) as well as Kaplan-Meier survival models.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|99 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Comparative Study of the Safety and Effectiveness of Ologen Collagen Matrix Versus Mitomycin-C in Glaucoma Filtering Surgery
|Study Start Date :
|September 2011
|Actual Primary Completion Date :
|December 2013
|Actual Study Completion Date :
|December 2015
Experimental: ologen Collagen Matrix
When performing glaucoma surgery, a trabeculectomy, use ologen Collagen Matrix instead of MMC before closing the conjunctiva
Device: Use of ologen Collagen Matrix in trabeculectomy (ologen)
Place ologen CM on the top of the loosely-sutured scleral flap under conjunctiva before suturing. It is recommended to suture the scleral flap with 1 or 2 stiches loosely for the convenience of future suture lysis and to coordinate with the tamponading effect of ologen CM to create a fluctuating scleral flap that prevents bleb wound adhesion and modulates aqueous humor outflow for ideal IOP control without leakage.
Active Comparator: Mitomycin-C (MMC)
When performing glaucoma surgery, a trabeculectomy, use MMC as antifibrotic agent before closing the conjunctiva
Drug: Use of Mitomycin-C (MMC) in trabeculectomy
After outlining and creating a superficial scleral flap, a cellulose sponge soaked with MMC(0.4mg/mL) is applied for up to 3 mins according to physician's routine method of application. The area treated is copiously irrigated with balanced isotonic solution. Alternatively, 15mcg of MMC may be injected intra-Tenon's at the end of the procedure. Patients receiving mitomycin will be billed as per operating room practice.
- Intraocular pressure(IOP) reduction [ Time Frame: At postoperative up to 24 months. ]
"Complete success" is consider for IOP less than 21mmHg(inclusive) with no glaucoma medications and with more than 20% reduction(inclusive) from baseline IOP.
Definition of success rate is calculated in percentage by the number of complete success patients over the total sample size.
"Qualified success" that meets the postoperative IOP requirements with postoperative glaucoma medicaitons and "Failure" of meeting the IOP requirements are the other efficacy parameters.
In the specified time frame, patients will also visit for record at day 1, 7, 14, 30, 90, 180 days, 12, 18, and 24 months.
- Postoperative complications and appearances [ Time Frame: At postoperative up to 24 months. ]
Inspections of hyphema, severe anterior chamber reaction, hypotony, supercholoidal hemorrhage, flat anterior chamber, endophthalmitis, choroidal detachment, wound or bleb leak.
Visual acuity, bleb appearance, and anterior chamber inflammation.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|30 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age > 30 years (inclusive)
- Uncontrolled treated glaucoma requiring trabeculectomy
- Subject must be able and willing to cooperate with investigation plan
- Subject must be able and willing to complete postoperative follow-up requirements
- subject must be willing to sign informed consent form
Exclusion Criteria:
- Known allergic reaction to MMC or porcine collagen
- Neovascular, uveitic, aphakic glaucoma, previous incisional glaucoma surgery
- Prior cataract unless clear corneal incision
- Previous conjunctival or strabismus surgery
- Participation in an investigational study during 30 days prior to trabeculectomy
- Ocular infection within 14 days prior to trabeculectomy
- Pregnant or breast-feeding women
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01440751
|United States, Arkansas
|VoldVision-Holf Eye Clinic
|Rogers, Arkansas, United States, 72756
|United States, Illinois
|Northwestern Memorial Hospital
|Chicago, Illinois, United States, 60611
|United States, New Jersey
|Institue of Ophthalmology and Visual Science
|Newark, New Jersey, United States, 07103
|United States, New York
|Glaucoma Associates of New York
|New York, New York, United States, 10003
|New York Eye and Ear Infirmary
|New York, New York, United States, 10003
|United States, Oklahoma
|Dean McGee Eye Institue
|Oklahoma City, Oklahoma, United States, 73104
|United States, Pennsylvania
|Wills Eye Institue
|Philadelphia, Pennsylvania, United States, 19107
|United States, Texas
|Glaucoma Associates of Texas
|Dallas, Texas, United States, 75231
|Principal Investigator:
|Robert Ritch, MD
|Robert Ritch, MD, LLC.
|Study Director:
|Steven Sarkisian, MD
|Dean McGee Eye Institute
|Study Director:
|Robert Fechtner, MD
|Institute of Ophthalmology and Visual Science
|Study Director:
|Michael Pro, MD
|Wills Eye Institue
|Study Director:
|Steven Vold, MD
|Boozman-Hof Eye Clinic
|Study Director:
|Angelo Tanna, MD
|Northwestern Memorial Hospital
|Study Director:
|David Godfrey, MD
|Glaucoma Associates of Texas
|Study Director:
|Paul Sidoti, MD
|New York Eye and Ear Infirmiry
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Aeon Astron Europe B.V.
|ClinicalTrials.gov Identifier:
|NCT01440751 History of Changes
|Other Study ID Numbers:
|First Posted:
|September 27, 2011 Key Record Dates
|Last Update Posted:
|November 1, 2017
|Last Verified:
|October 2017
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
ologen collagen matrix
filtering surgery
Ocular Hypertension
Eye Diseases
Antibiotics, Antineoplastic
Antineoplastic Agents
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors


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Kirsten Reynolds is an English artist whose diverse practice encompasses, drawing, painting, sculpture, collage and print-making as well as the creation of works using sound, light, electronics and found objects. Reynolds also plays in a number of bands having been introduced to drumming, percussion and scrap metal instrument building when she joined pyrotechnic metal percussion ensemble The Bow Gamelan in 1990. During the early 1990s Kirsten toured extensively with The Bow Gamelan and shows were presented in a huge number of extraordinary situations from a disused power station in Belgrade, to an abandoned zinc factory in Katowice, Poland. A spectacular pyrotechnic percussion event took place on the roof and chimney of the (then disused) Bankside Power Station that was to soon to be renovated and become the Tate Modern. The Bow Gamelan was the centre of a large-scale percussion and pyrotechnic water-borne extravaganza in Copenhagen Harbour working with Harald Viuff (Illutron DK) on the occasion of the Tall Ships Race celebrating Copenhagen's status as Cultural Capital of Europe in 1996.
After playing drums and bass in legendary noise band Headbutt, Reynolds went on to form Project Dark with fellow musician and artist Ashley Davies. Project Dark make limited edition 7-inch singles from everyday materials such as human hair, circular saws, glass and biscuit. These extraordinary discs have been shown in many international exhibitions and form the basis of a witty, irreverent live DJ show that has been presented everywhere from the inside the anchorage of the Brooklyn Bridge, New York to the Queen Elizabeth Hall, London as part of John Peel's Meltdown '98.
In 2000 Project Dark were commissioned by curator David Toop to show at the Hayward Gallery alongside Christian Marclay and Brian Eno in Sonic Boom, the first international sound art exhibition in the UK. The piece involved 3 gramophones, sculptural discs, a high-voltage sparking stylus, a miniature video camera and live giant spark projection. Project Dark went on to perform in the Hamburger Bahnhof, Berlin as part of the live programme accompanying the influential Sensations exhibition. Project Dark showed a selection of their catalogue of unusual discs in the group show Groove: Artists and Vinyl at the Huddersfield Art Gallery in 2002.
In 2003 Reynolds co-founded the art and music label Phono Erotic releasing limited edition records and related artworks. Reynolds plays in a number of musical groups including, the electronic rhythm collision duo K&A, mambo pop outfit, Pommagne and The London Dirthole Company, a garage punk 10-piece with 4 stand-up drummers. The London Dirthole Company have released four 7-inch singles and two vinyl albums and play regularly in London and in 2008 toured in the US collaborating with American musicians for shows in Nashville, Memphis and New York and a WFMU radio session in New Jersey.
Since the year 2000 Reynolds has collaborated on various large-scale outdoor sound art events working with percussion, steam, pyrotechnics and many custom-made devices generating spectacular sonic and visual installations and live works. These events are all site-specific and respond to a wide range of locations from forests to car parks. Blast was a large-scale outdoor event created in collaboration with artists Mark Anderson, Richard Wilson (and others) celebrated Birmingham's industrial past using steam, fire, propane, pyrotechnics, percussion and a fog horn to animate the 300 metre-long disused site of the original Curzon Street Railway Station in the city centre over two nights in 2007.
In 2006 Reynolds began a curatorial collaboration with Line Rosenvinge creating the This is Not a Pen project. Subtitled 'The Gallery for Your Pocket', the project commissions artists to design a work within the format of the float pen; a tiny space with a single moving part. This is an ongoing series and to date pens have been produced by Matt Collishaw, Peter Callesen, Katherine Ærtebjerg and Danish artist group Paint Over.
In October 2008 Reynolds presented a new live sound-art performance in collaboration with Neil Fraser of cult band Tindersticks. ' A Taste of Gramophotism' was premiered at the European Centre for the Arts, Dresden, Germany and was a live show employing music and video that developed ideas concerning the relationship between image generation and sound production when using physical objects and natural materials as original sources.
Reynolds developed new installation works for Power Plant; an outdoor sound and light art event that was originally commissioned in 2005 for the Oxford Botanic Garden by Oxford Contemporary Music. It was then presented by Contemporary Music Network for the Arts Council as part of Liverpool's European Capital of Culture 2008 and was seen by over 7000 people over 5 nights in Calderstones Park. Power Plant also features work by artists Mark Anderson, Anne Bean, Jony Easterby and Ulf Mark Pedersen and went on to be shown in the Royal Botanic Gardens, Edinburgh as part of the British Council showcase at the Edinburgh International Festival in 2009.
In November 2008 Reynolds was invited to contribute work to the group show Curious and Curiouser curated by Alan Rankle at the Galerie Rebecca Kormind in Copenhagen, Denmark. Rankle & Reynolds presented collaborative works in a joint exhibition On the Edge of Wrong at the Fondazione Stelline in Milan, Italy in February 2009. Further work in the On the Edge of Wrong series has been shown at Federico Rui Arte Contemporeana, Milan, Italy and Mya Lurgo, Lugano, Switzerland. In June 2011 Reynolds presented new works a solo show at Gallery B15, Copenhagen, Denmark showing new photographic light drawings. This new work capturing fleeting moments of intuitive drawing in space created much interest and was the subject of a major article in the Danish national newspaper Politiken by art critic Trine Ross.
In January 2011 Reynolds showed new sound and light installations at the hugely successful Power Plant event at the Sydney Festival in Australia. This show was developed and was a key event at the Sydney Festival, January 2011, Hong Kong Arts Festival, February 2011 and at at Ten Days on the Island Festival in Hobart, Tasmania in March 2011.
In July 2012 Reynolds was commissioned by the Art Association of Novo Nordisk, Copenhagen, Denmark to create 1400 individually different light drawing photographs. 1300 have been presented to the members of the association and the remaining 100 are available and are being exhibited in London, Berlin, Copenhagen and Norway.
Reynolds recently collaborated with chemo-acoustic artist Bastiaan Maris on new interactive crazy golf track 'The Last Hole' made from 300 used James Last vinyl records. This formed part of an artist-made crazy golf course on the airfield of the now disused Tempelhof Airport, Berlin; an internationally unique vast cultural space in the centre of the city.
SMASH HITS a new Project Dark performance was presented at Guerilla Cinematography in Athens in March 2012 and Scrap Club, London May 2012. A very special one off event using the sounds and image of massed seagulls in flight was part of the Dear Serge event on the roof of the iconic De La Warr Pavilion, Bexhill in August 2013.
The London Dirthole Company released a new vinyl EP MODERN IST on Outsider Sound in March 2013. An LP 'The Sounding Alley Tapes' was released on vinyl on Squoodge Records (Berlin) with the CD and download versions on Reynolds' own PHONO EROTIC label. A new album by The Blood Tub Orchestra will be released in 2017.
In September 2016 Reynolds was invited by Maerz Contemporary to make new work on a residency in Molde, Norway. A solo exhibition of paintings, prints and photographs followed in December.
Power Plant's next show will be at the Auckland Arts Festival in March 2017.
Kirsten Reynolds next solo exhibition will be at the Lucy Bell Gallery opening on 18 March 2017.


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A Front Office of OneToday is Deion Branch's last day as an NFL general manager. The week the Patriots gave their holdout wide receiver to work out a trade for himself expires Sept. 1.
Although almost every team in the league could better itself with a receiver of Branch's caliber, including some franchises with distinct weakness at the position, the flesh market has been quiet so far. Make that silent. As the Patriots well knew, it was next door to impossible for Branch to find a team that'd give him the new contract he wanted AND fairly compensate the Pats for losing his talents. Otherwise they wouldn't have let him try.
So the odds, as they always did, favor some sort of compromise between Branch and his current employer. That's not the point of this post, which is more in the nature of idle speculation. What if Branch had succeeded in his quest?
Suppose Branch had found a sucker, er, Super Bowl hopeful willing to pay him big money and give the Pats a package they found irresistable? Wouldn't it then make more sense for New England to turn down the deal and give Branch a new contract with one condition, that he spend his offseasons as Scott Pioli's assistant? We have to assume the Pats have already explored dealing Branch. If he could succeed where they failed, his hidden talent as an executive would clearly outweigh whatever draft picks they'd get for his playing services.
The "work out your own trade" gambit is not uncommon in NFL contract impasses. Sooner or later the laws of chance dictate that some progressive franchise will tell a recalcitrant star, "You're hired! Again! And twice!"


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So how is everyone? Had a great day? I won't even tell you about mine but I will show you a box we made, ummmmmmm, can't remember, a couple of months ago (I think!) at Crafter's Anonymous. Love the box but couldn't work out how to decorate, as I absolutely love the box just the way it is. But it does need something. So tonight while I am watching X-factor I will try and work it out and let you know how I go tomorrow! But for tonight, I will show you why I am struggling so bad. This is a great size box and I am struggling to want to give it away!!
See, how cute is this box, I love it! So you will have to check back tomorrow to find out if I did anything with it, lol.
Card: Soft suede, dsp- soft subtles and very vanilla
Tools: 3/4" circle punch.
I know, you think I should finish it!!
Have a lovely night and I'll see you tomorrow....


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There is a wide variety of Dental Instruments available on our website which covers all the bases. Some of the most important dental products are as follows –
- Dentist Chair – as the name suggests, it's a recliner chair which is customized for dental procedures. A modern dental chair is electronic and its height can be adjusted according to need. It is accompanied with a water line, a spit bowl and an overhead light is attached.
- Mouth Mirror – they are used to examine the teeth and also cheeks and tongue during the examination. Mouth mirror is the most basic tool required by a Dentist.
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Black morocco mounted with brown-carmine and orange-red morocco, blind- and gold-tooled. The covers are tooled in a broad panel encompassing various elements: gold lines around a blind-tooled roll with hatchings, corner compartments and rectangular compartments, partly in onlaid leather in shades of red and brown; again gold lines around blind-tooled hatchings and compartments with decorative tooling on mounted leather. The central panel is completely tooled with blind parallel lines. The spine has four wide false bands, mounted with onlaid leather, and compartments tooled with various decorations.
We know from a label on the inside of the front cover that this binding was made by Friedrich Kolb. Nineteenth-century bookbinders were more inclined to sign their bindings than their predecessors: it is estimated that about 10% had some form of signature, for instance a label, a black stamp on an end leaf or gold-tooling on the tail end of the spine or the inside of the front cover.
Friedrich Kolb was born about 1810 in Hachenburg near Bonn. Like so many contemporary young German bookbinders he must have left his native country because it offered virtually no possibilities of making high-quality bookbindings. He settled in Amsterdam, where he married in 1834. The bookbinding illustrated on the opposite page proves that he was a true master of his craft: it belongs to the very best made in our country at the time. It displays the contemporary ideals of form in a far more harmonious and balanced way than other bindings. The classicistic tooling, in vogue since about 1800, had already grown from sober to very ornate, and full advantage was taken of the possibility to use gold-tooling and blind-tooling as well as many-coloured leather onlays. Many bookbinders added imprints of plaques to the more usual rolls and small tools, but this is not the case on this binding: the central panel has been so elaborately tooled with separate lines, that it looks like a plaque. Unfortunately Kolb's talents were granted only a short life; he died on 27 July 1843.
From a technical point of view the binding is also characteristic of its time. The block has been sewn on cords in saw cuts, resulting in a smooth back. The wide bands visible on the spine therefore do not cover the sewing supports. They are made of pieces of cardboard on an inlaid back that comes off the spine when the book is opened - a technique that is fundamentally different from the technique used before 1800. During Kolb's lifetime the Dutch bookbinders changed en masse from hand-made binding to machine binding, with an almost complete decline of the craft of bookbinding in the third quarter of the century.
Oratio de progressu physiologiae plantarum. Bookbinding made by Friedrich W.I.C. Kolb. Amsterdam, 1835. Contents: Guil. Henr. de Vriese. Amstelodami, ex typographia Civitatis Publica, 1835. 144 C 5


text: Santa Cruz Criminal Defense Blog 2011 August Car Insurance and vehicle code violations Previous Post | Next Post Car Insurance and vehicle code violations Posted By Christine McGuire || 18-Aug-2011 Regarding vehicle liability insurance changes On January 1, 2006 all insurance companies were required to report insurance status to DMV for all private use vehicles. As of July 1, 2006 law enforcement and court personnel have access to DMV records to verify that your California registered vehicle is currently insured. Effective October 1, 2006 your vehicle registration is subject to suspension if the liabiiity insurance is cancelled or if your insurance has not electronically provided evidence of insurance when you purchase and register your vehicle or if you provide DMV with false insurance information. You must carry proof of insurance in your car at all times. If you are arrested for a misdemeaor or felony traffic related offense contact Christine McGuire, the Santa Cruz criminal defense attorney and the Santa Clara Couty criminal defense attorney. Categories: Criminal Defense, Domestic Violence, Driving Under the Influence, Drug Abuse, DUI, DUI with Injury, Expungement, Intellectual Property Crimes, Juvenile, Misdemeanor, Murder, Restraining Orders, Sex Crimes, Vehicular Manslaughter Share Post


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Buyers hanging as condo project folds
An uptown condo tower's crumbling finances have sent the project into foreclosure. Now, buyers are wondering if they'll ever see their condos – or the money they invested in them.
The 21-story Park building, a skeleton of steel at Caldwell and Third streets, will be auctioned to the highest bidder at noon Aug. 7 at the Mecklenburg County Courthouse. Some condo owners have already filed lawsuits against The Park's developer, Verna & Associates, and others are talking of banding together to do the same, they said.
"We feel fooled, because we were told things that were not true," said Raphael Goldstein, 59, who signed a contract four years ago on a condo for his college-age daughters. "I don't know what's going to happen, but I fear for the worst."
The foreclosure order Tuesday in Mecklenburg Superior Court against Verna & Associates' development company, 222 South Caldwell Street Ltd. Partnership, ended months of uncertainty after work on the $43 million project stopped this spring.
According to court documents, the Charlotte-based developer defaulted on its $30.7million construction loan, which was to be paid by February. Verna owes more than $27 million to its lender, BB Syndication Services Inc. of Wisconsin.
In addition, contractors and others who worked on the condo tower have filed liens and lawsuits against the company, claiming more than $4.9 million in damages.
Verna & Associates officials did not return phone calls Wednesday. The lender's attorney, Tim Griffin of Poyner & Spruill in Charlotte, declined to comment.
Pete Verna, who led The Park project until he retired last year, announced plans for the tower in 2000. The luxury condo building was named for its planned rooftop park, which was to include a pool, fitness center and putting green. Condos were priced as high as $700,000.
In March, Verna told the Observer that work had slowed – but that the 106-unit tower was about 80 percent complete and could be finished by the fourth quarter. Nearly all of the units had been sold.
Goldstein, a real estate broker, put $35,000 down on his $300,000 condo in June 2004. He and his family liked the two-bedroom unit's sweeping view of the Bobcats arena and Verna's good reputation, he said.
Despite several delays, Goldstein didn't become concerned until about two months ago, when he drove by the building and noticed that work had stopped. A few days ago, he heard about the imminent foreclosure, he said.
Goldstein said he hopes someone can finish the condo tower. If not, he wants his money back. But he's worried that a clause in the contract which says the developer can spend owners' deposits once construction begins means his deposit is gone.
Work also stopped this year at 210 Trade, the uptown condo tower at the EpiCentre – part of a dispute between its developer and the EpiCentre's.
Two other towers have been postponed: One Charlotte, near the Westin, and 300 South Tryon.
The problems don't signal the end of the uptown condo market, though, said developer David Furman of Centro CityWorks. Units sold quickly at The Park and 210 Trade, he said.
"None of those were reflective of bad market conditions. (The Park) was ahead of most of the projects out there. The market loved it."
Staff researcher Marion Paynter contributed.


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"I truly feel we now have a programme to be proud of – one which I know will add benefit to the BMW network as a whole."
"Several managers telephoned after the event to say that they felt this was some of the highest quality training they have ever received."
"You have continually added value at personal and strategic levels. There are now significant initiatives in place within our business which started out as an idea from a be more effective workshop."
"The development programme you delivered for the senior and line managers and team leaders enabled us to achieve our target of a £450,000 cost reduction from improvements in processes and communication. In addition the programme enhanced our capability to such an extent we were able to cope with a doubling of output during the annual peak."
Be More Effective provides a unique blend of consultancy services alongside developing internal communication and training solutions that create advantageous change, improve key processes, enhance employee engagement, lift performance, address specific business challenges and develop key business skills; everything you need to fulfil the ambition you have for your organisation.


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Colin started out his radio career on BBC Radio Leeds at the 'ripe old age' of 15 a week before leaving school, and then worked the clubs as everything from compere to bingo caller!
He joined Yorkshire Television in 1975 after being on several 'not so legal stations' in admin and did some stand-in work at Pennine Radio and Radio Aire, before doing a stint in Hospital Radio
In 1984 Colin moved to the North East of England to work at Tyne Tees TV, a station that didn't stick to job descriptions – if there was a 'Job' to do, you did it… so he ended up doing everything
from Accountant to Continuity Announcer, and then made the move into Management and retired from Broadcasting as a senior Manager at ITV PLC in 2010.
Since then Colin has presented programmes on several Internet Stations. His music passions are wide and varied from Northern Soul to good old fashioned Rock Music.
Jordan…..Fridays 6 to 8
as one of the youngest presenters at just 17yrs old, Jordan is fast growing in popularity his cheeky chart and dance show air's on Friday evening between 6 & 7 pm , Jordan has also dj'd on Reading college radio and has taken several lead roles in school productions , as some of you may or not know Jordan suffers from severe autism, but loves nothing more than to entertain and bring you all your chart favourites, he also likes being his dad's sidekick" first mate Jordan" on the feel-good Friday show
Alan Michel.. Friday's 6 to 8
Aka captain Al, with wife Rose , son Adam and Jack Richards, co founded power radio back in April 2014. Al comes from a musical background having played bass guitar in a modern country band for 18yrs.. First got into radio back in 2013 doing special occasion shows with son Jordan on another internet station, since being on power many new friends have been made,and many to come . "I enjoy the challenge of finding remixes of older tunes, although Rose seems to be able to find them quicker, and far better mixed"… Catch Al each Friday between 6 & 8pm , and on the odd Bank holiday, oh and don't forget Christmas
Caroline first got involved with music and discos at the age of 13 at school.
She liked it so much, as soon as she could, she got her own equipment using the princes trust and started storm discos after that it moved onto angels entertainment and took on large venues for lady's nights corporate events large charity events along with being resident dj in clubs in Nottingham and Eastbourne.
In 2010 she had all her equipment stolen for her lockup and had to start all over again after recovering from the theft she was doing some smaller discos to get the big show back on the road.
At that time she met craig who still had his disco in moth balls and persuaded him to let her join the two shows together and she was off again doing the shows she loved doing Craig at the time was doing shows for power radio and got her involved with the radio.
QUOTE form Caroline DJ angel (I CAN SHOUT AND SCREEM AT 500 PEOPLE AT AN EVENT BUT THE RADIO JUST SCARES THE —- OUT OF ME BUT IM GETTING BETTER)
Saturday breakfast show 10 to 12
Sunday CORKYS COUNTRY SHOW 10 to 12
Craig has been involved in music in one way or another in the early years of his career he built his own mobile disco and did discos for all the local schools did weddings birthday discos ect.
That was just the start then moved into the clubs as a dj then setup a small radio station ( AM pirate )
He lived in Spain for two years presented as a stand in dj for valle radio before getting his own show it was on valle that craig got his nickname CORKY the story goe's that the owner of valle radio had a night club and craig said he could drink one shot of each bottle on the shelves and fell over at the corkys hence the name corky.
Came back to the uk and presented a show on AMR RADIO — EASTBOURNE RADIO and now on POWER RADIO and STORM FM
Friday's 8 to 10 Friday night thumpers
Jack the man that wherever he lays his hat he calls home. A life spent in music as a Dj, Producer, Engineer, Radio Presenter, Jack has many different faces and Names when it comes to the music industry.
The Radio Presenter
The Producer making his own tracks since the early 90's
Ghost writer
The Dance DJ that plays house / techno / tribal at clubs festivals worldwide
For many years a record label owner / promoter running dance events as well as owning and running bars / pubs and clubs.
Getting Jack to write anything about himself impossible, getting Jack to talk impossible to Stop.
Wednesday's from 7
Robin Dee hosts "Robin Dee's BIG Country", a fast-paced show playing the very best in New Country and Country Rock from many new unsigned artists with their own original material.
Robin says, "It's a barn-stormin' dynamic show which only goes to prove that there's a lot more to country music than songs about the crops failing, the dog dying, and Grandma being hit by a train! If a song's got a pickup truck, a dusty road, and a beautiful girl in it, then it gets my vote!
"A little bit about me? How long have you got? Very briefly, a lifetime of experience in radio presentation and production over the years, beginning with hospital radio, then local commercial radio, progressing into internet radio which I have been very active in since 1999. All of this alongside my main careers of car salesman, used car dealership proprietor, retail petroleum equipment engineer, and finally, truck driver. Now retired, I can dedicate my time to my first love – radio!
"Music tastes? All 60s and 70s, the more obscure the better! But I like modern stuff too if it's good. And of course ALL country. Just love it!
"Other interests? Radio, music, mountain biking, classic cars (own an MGB), dining out, oh – and did I say radio?
"Anyway, here's a warm invitation to join me on "Robin Dee's BIG Country", where the coffee pot is ALWAYS on, there are huge helpings of Grandma's home made apple pie, and if you're really lucky, a shot of Grandpappy's finest moonshine! Y'all call in now!"
Intro to Mouth Meltdown Fridays at 4pm
There's nothing complicated about this show, it's just me sharing some of my favourite tracks, having a bit of a chat and maybe dropping in one or two features as the mood takes me.
Typically I play popular music from the seventies onwards. Why "Mouth Meltdown"? Well, you'll have to listen to find out!
Having lived "Down South" for most of my life, my roots are still firmly entrenched in the North East of England, among the beautiful countryside of the Durham and Yorkshire Dales.
I consider myself very lucky as when I was a child my Grandparents had a farm and I had an idyllic childhood as weekends were spent on the farm talking to the animals and playing on the farm machinery the health and safety police wouldn't allow that these days!
Eventually I had to grow up and get a job. 🙁
At eighteen I joined the Fire Service where I made some great friends and, as you can imagine, had some very moving experiences.
Life has taken me many places since then, bringing me into radio at a pretty late stage in my life, however I enjoy it enormously, sharing my love of music with my audience and chatting about anything that comes into my head.


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One of the UK's last remaining West Country ketches will visit this year's Bristol Harbour festival. This historic vessel was launched on 29 May 1907 at the Bridgwater yard of FJ Carver & Sons and sold to Colthurst Symonds, a local brick and tile producer and who named the vessel after his daughter Irene. She sailed thousands of voyages as a cargo vessel carrying tiles and bricks, coal and clay.
In private ownership since 1965 and following many years of professional and loving restoration Irene now runs traditional holidays around the UK and beyond.
Irene was awarded the prestigious UK flagship of the Year in 2015 in recognition of the active role she plays in promoting our maritime heritage. She is part of the National Historic ships fleet of important working vessels that played such a vital role in our history.
Come and find out more about her amazing history. Located by the M shed from Friday 21st July. www.ireness.com


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There's nothing quite like curling up in a cozy blanket handmade with love, is there?
For this issue's Stitching Hearts project, we're collecting knit and crochet squares which will be sewn together to make blankets. The blankets will be donated to a shelter, but we haven't decided which quite yet. If you have a suggestion of where you're like them to go, let me know!
All squares should be a multiple of 10 cm by 10 cm. Use whatever colour, material and pattern you like. Practice your basic crocheting skills or knit a heart into it! We don't care as long as the squares fit together in the end.
We'll gather on Saturday June 4 at noon near the duck pond at Assiniboine Park in Winnipeg to sew the patches together. Not in Winnipeg? No problem! Organize your own event and send the blankets to whichever groups you think could use some love, comfort and warmth.


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An exquisite way to celebrate the bounty of Winter. Sweet, juicy apples meet tart delightful cranberries in a melody of flavor that does not disappoint. Eating seasonally brings your soul and body closer to nature. It is invigorating to eat what the season provides and to utilize it in fun new ways. Whenever I bake or cook my senses come alive. It is beyond taste, you have to use your sense of smell, sight and most importantly touch. We so often forget to use our hands in the kitchen but it truly transforms the dish when you infuse it with your love. This recipe will look stunning on any holiday table. Enjoy beauties.
by: Michelle Gerrard-Marriott, The Vibrant Kitchen & Home
The Goods
- 1 cup brown rice flour
- ½ cup GF oat flour
- ½ cup buckwheat flour or all purpose gluten-free flour
- ¼ cup arrowroot starch
- 4 tbsp coconut sugar/dry sweetener of choice
- pinch of sea salt
- pinch of cinnamon, nutmeg, clove and ginger
- ½ cup coconut oil
- ½ cup water
- ¼ cup cider vinegar
- 4 pounds sliced, peeled mixed apples, I love granny smith, pink lady, and some heirlooms if you can find them like Baldwin!
- 12 ounces fresh cranberries
- One lemon zested and juiced
- One Orange zested and juiced
- 2 cups coconut sugar
- 4 tablespoons Maple Syrup ( Or Organic Honey if you are not Vegan)
- 1 tablespoon arrowroot powder
- ½ teaspoon cinnamon
- ¼ teaspoon nutmeg
- ¼ teaspoon cloves
Get Cooking
Preheat oven to 350 F and lightly oil a 10 inch pie pan. In a large bowl, combine your flour blend, sea salt and coconut sugar. In a smaller bowl whisk together coconut oil, water, and ACV. Pour oil mixture into flour mixture and combine with your hands until well mixed. Dough should be a little moist.
Once combined divide into two. Press one section into pie pan until it forms a beautiful bottom crust. Stick with a fork a couple times and bake for about 15 minutes. Roll our remaining dough and cut out Autumn Leaves, Pumpkins or whatever your heart desires! Set aside whilst making the apple cranberry filling!
Core, peel, and slice your apples. Put in a large bowl with your washed cranberries. Add lemon juice, orange juice, lemon zest, orange zest, coconut sugar, maple syrup and spices. Mix gently and allow to sit for 15-20 minutes. This allows all the flavors to develop.
On Medium/Low heat allow a saucepan to warm. Add in your apple + cranberry mixture. Allow everything to become caramel-like and delicious. Taste along the way, if you want it a bit sweeter you can add more coconut sugar or maple syrup! Add your arrowroot towards the end and mix gently until combined and thickened. Pour your mixture into your prepared pie crust. Top with your cut outs and sprinkle a bit more coconut sugar on top of the pie! Put in oven and bake for about 30 minutes until golden brown.
Once out of the oven allow to cool for 15- 20 minutes before serving! Serve with Coconut Ice Cream or Coconut Whipped Cream! Enjoy every last bite!
Michelle Gerrard-Marriott is the founder of The Vibrant Kitchen & Home, a site for wellness and elegant recipes that nourish the body and soul. Find her on Instagram and Facebook.


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Bump La La La (Prod By Kajmir Royale), the latest cut from Kid Ink. It was released on Monday, December 27th, 2010. Things are improving for Kid Ink with each new offering, and La La La (Prod By Kajmir Royale) is certainly no exception. It's a worthy addition to the Kid Ink's catalogue, which has seen much evolution as of late. We're definitely anticipating the next step.
Check out Kid Ink on Insane (Prod by Cardiak). If you dig this, visit Kid Ink's profile for the latest info, news, songs, and mixtapes. Follow Kid Ink on Facebook and Twitter, if you aren't already.
How does this compare to Kid Ink's previous work?


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A beautifully loved & care for home with GREAT bones, ready for your special touches. Enjoy the large eat in kitchen or an abundance of natural sunlight in the three season sun room. Many maintenance free features including siding, gutter guards & brand new energy efficient hot water heater. The home sits in a wonderful family focused neighborhood, situated in a quiet, low-traffic area, and great schools! The perfect home for your family to grow & make memories for years to come.
Eat-In Kitchen, Liv/Dining Combo
Concrete, Full, Garage Entrance
Enclosed Porch, Main Floor Master, Sun Room
Storm Windows, Outbuilding(s), Storm Doors, Wood Windows
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Listing information last updated on November 21st, 2019 at 6:53am CST.


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Jena, Anirudha and Munichandraiah, N and Shivashankar, SA (2012) Morphology Controlled Growth of Meso-Porous Co3O4 Nanostructures and Study of Their Electrochemical Capacitive Behavior. In: JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 159 (10). A1682-A1689.
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The morphology of nanocrystalline Co3O4 synthesized through microwave irradiation of a solution of a cobalt complex is found to depend reproducibly on the conditions of synthesis and, in particular, on the composition of the solvent used. Despite the rapidity of the process, oriented aggregation occurs under certain conditions, depending on solvent composition. Annealing the oriented samples leads to microstructures with significant porosity, rendering the material suitable as electrodes for electrochemical capacitors. Electrochemical analysis of the oxide samples was carried out in 0.1M Na2SO4 electrolyte vs. Ag/AgCl electrode. A stable specific capacitance of 221 F/g was measured for a meso-porous sample displaying oriented aggregation. Stability of these oxide materials were checked for longer charge-discharge cycling. (C) 2012 The Electrochemical Society. DOI: 10.1149/2.002210jes] All rights reserved.
|Item Type:
|Journal Article
|Additional Information:
|Copyright for this article belongs to ELECTROCHEMICAL SOC INC, USA
|Division of Chemical Sciences > Inorganic & Physical Chemistry
Division of Chemical Sciences > Materials Research Centre
Division of Interdisciplinary Research > Centre for Nano Science and Engineering
|Depositing User:
|Francis Jayakanth
|Date Deposited:
|07 Dec 2012 08:32
|Last Modified:
|07 Dec 2012 08:32
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25-02-2014 | Mental health | Article
Residual symptoms linked to poor functioning in euthymic bipolar disorder
medwireNews: Residual symptoms are associated with functional impairment in euthymic individuals with bipolar disorder, a large observational study has shown.
The finding may support a strategy of targeting residual symptoms with specific therapeutic interventions, say the study authors writing in the Journal of Affective Disorders.
In the OPTHYMUM study, Ludovic Samalin (Centre Hospitalier et Universitaire, Clermont-Ferrand, France) and team recruited 525 adults with bipolar disorder from outpatient departments across France.
Patients were euthymic at enrolment and had not experienced an acute mood episode for at least 6 months. Their mean age was 47.8 years, 39.8% were male, 59.0% had bipolar I disorder, nearly all were receiving pharmacological treatment and around half were in ongoing psychotherapy.
Using a Global Assessment of Functioning score cutoff of 60, as recommended by DSM-IV, the researchers classified 35 patients as having a low functional status and the remainder as having normal functioning.
Comparison of these two groups revealed differences in clinical course, symptoms and treatment. For instance, low-functioning patients were more likely than others to have a manic-predominant polarity, to have experienced psychotic symptoms and to have a history of addiction and hospitalisation.
Patients with low functioning were also more likely to be taking second-generation antipsychotics and benzodiazepines and less likely to be taking anticonvulsants or to be in psychotherapy compared with normal-functioning patients.
Low-functioning patients had significantly lower scores on the Multidimensional Assessment of Thymic States instrument, at 96.7 versus 102.2, indicating general inhibition, as well as a higher degree of "morningness" and more sexual dysfunction.
Finally, patients with low functional status reported more cognitive and stigma complaints, including greater social and family stigmatisation, more emotional lability, more emotional anaesthesia and greater impairment of planning ability and psychomotor retardation.
Taken together, these results indicate that functional status is associated with many aspects of life in euthymic individuals with bipolar disorder. "In particular, residual symptoms were observed more frequently in euthymic patients with low functioning," write Samalin and co-authors.
"Several aspects of the so called 'residual symptoms' (depressive or manic subsyndromal symptoms, disruption of circadian rhythms, perceived cognitive dysfunction, sexual dysfunction…) are associated with functional impairment and may represent specific treatment targets," they remark.
medwireNews (www.medwirenews.com) is an independent clinical news service provided by Springer Healthcare Limited. © Springer Healthcare Ltd; 2014
By Joanna Lyford, Senior medwireNews Reporter


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Hyderabad, with a case load of 18 lakh diabetics, is seeing a sharp rise in cardiac problems which is emerging as a big worry for the government and medical experts in the city, said experts at a health seminar in the city. "The situation is grave as there is 90 per cent chance of diabetics dying of heart disease. Similarly, recent trends show how cardiac patients have undiagnosed diabetes, which ordinary blood tests do not reveal," Dr Ganesh Mathan, senior cardiologist at Sunshine hospital, said at 'Icon - 2016', a seminar on diabetes health awareness in the city. Recent studies show how one in six persons above 30 years of age in Hyderabad are becoming diabetic, and every year the number is increasing by 20 per cent.
"Lack of screening is contributing significantly to diabetes case load in the city, with 22 per cent of all general patients in both Telangana and Andhra Pradesh turning out to be diabetic," said Dr Sanjoy Paul, senior diabetologist at Apollo Sugar, at the seminar organised by Hyderabad Bangalee Samity.
Speaking at the event, principal secretary, health, Rajeshwar Tiwari explained the seriousness of diabetes and how the government was learning to effectively manage the disease from developed countries and planning to implement it here.
In Telangana, awareness campaigns are much more focused on communicable diseases, but not much on lifestyle diseases, Dr Paul emphasised.


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By Cornelius Potgieter
With Imperial Destruction's next Night of Destruction looming nearby, I chatted with the main man behind the scenes, Wian Bester, in order to find out more about this new, exciting concept that is fast gaining support in the local metal scene. Check out what he had to say below:
1. Tell us a bit about how you came up with the Geraasplaas concept?
Geraasplaas has been a vision that Imperial Destruction and a few friends have shared for quite some time.We were always in the front row at every Ramfest and Metal4Africa event. but felt we needed more metal events, especially seeing as the heavier music doesn't get showcased at bigger festivals anymore. The idea started out when we played at a good friend's birthday party back in high school, We played a few other house parties, but the cops weren't as enthusiastic as we were. By luck we manged to get hold of a venue in Gordons Bay where we had our first official NOD followed by two other successful events, including a fundraiser for a friend lost in a bike accident. On my 21st birthday we even managed to get local idols Mind Assault to play alongside reggae legends The Rivertones at a craft beer brewery in Somerset West. For us it was just about the party with friends, and the vibe caught on! When my folks moved to a farm in Riversdale, it was like a blessing from the Gods of Metal to take our vision to open skies. Our one mate Richard jokingly said: "Lets make some geraas op die plaas (make some noise on the farm)", and then the name just stuck. We first tried to host our event in collaboration with the Aloe festival in Albertinia but some locals took it among themselves to boycott us from the festival to protect themselves and their children from us "devil worshipers". Some physical persuasion and a few black eyes later, we decided it would be best to move the event to our farm as the original plan intended. In less then a week we build our own stage in our shed, lit up some bonfires and let the good times roll. It's still a learning process but we are humbly learning and improving after each event.
2. How have your events been received by the local metal scene?
The second event had double the amount of attendees and I take great pride in seeing Jason's artwork on shirts around Cape Town and even some folk around Gauteng and Port Elizabeth. We even had some German headbangers at the festival who said it was their first metal event in South Africa. Our event may look like a peanut compared to Wacken, but they had a blast with the locals. Our staff here on the farm are proudly wearing their Geraasplaas shirts around town and defending their new found passion. Not only did we find a new safe haven for alternative music but we are managing to grow our family. We have received plenty of great feedback and people are begging for the next one! What makes our events so unique is the fact that it's something new. People are tired of the same old venues, it's nice to explore some new parts of the Western Cape and make some new friends along the way.
3. What can attendees to your next festival expect?
Expect a proper two full day festival with bands from all across the country. PROPER TOILETS!!! We also want to expand our stalls into a nice craft market area with more variety for attendees. We are looking at building an outside stage soon enough once we see a bigger growth in support, which I hope will be in the next year.
4. Are you planning on eventually showcasing international bands at your events?
Our first priority would be to establish a solid and secure venue for the local scene but I would love to bring down bands from neighboring countries and even new friends from Romania! One of my biggest dreams are to have Slayer and Amon Amarth playing in my backyard! Sadly the ZAR is pretty shite and it would cost a fortune. But hey, dream big, ya know?
5. Do you have any other big plans and/or events in the pipeline for the near future?
Doing two events that close to each other was a big gamble but we managed to pull it off. We will be hosting another event in December here in Riversdale, just to ensure we have enough time for proper planning. I would love to build the two outside stages and our beer tent in the next year, but farming is our first priority, and without sponsors it can be quite a struggle. That's why we will forever be grateful to Wrath inc. for their contribution for last years show and big ups to the lads from Bokgot for all their help! the Bokgot Brothel is still standing proudly. We want to make Geraasplaas more than just about the music, it should be a getaway experience that can bring some tourism to this area. Personally experiencing Hellfest in France has shown me how a small town can benefit from such big festivals and I would love to make the event reach its full potential. We want to expand into a proper 4×4 course around the farm including hiking and cycling trails as well as proper camping sites for caravans etc., but for now our biggest concern is making the music happen! We are currently working on a mini open air event for 26th of March in Wellington. Check the page here:
6. Any final words to your fans and followers?
THANK YOU to everyone who has supported Imperial Destruction throughout the years and making this event possible. You're all defenders of the faith and we salute you, see y'all at the next one.


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Randyst signaled Herminicle to get ready. The paladin drew out his blade while the wizard prepared to cast a spell.
They would surprise the foul creature.
With a war shout to his god Pelor, Randyst leap to the monster, his longsword gleaming with energy. The goblin noticed the intruder and managed to side step out of the way, just in time to avoid a cleaving strike.
"Grr, you human no take Thork dinner! Me kill you, make cake with your eyeballs!" It growled in broken common, pointing towards the armour clad human.
Randyst turned and faced the goblin chieftan, pointing his sword towards it.
"Foul beast! I will not allow you devour this young one. Prepare to face the gates of oblivion evil one!"
The goblin let out a guttural threat but before completing it, was met by a mystic bolt that struck it square in the chest. The goblin staggered a bit, but did not fall. It looked around and spotted Herminicle.
"Rawr! you bring magic here? Thork have magic too!"
The goblin shot a dark bolt towards the paladin but missed. Randyst charged the creature, swinging his longsword, striking the chieftain who still held on.
This one is definitely a tough opponent, thought Herminicle.
Thork grabbed his mace – a weapon with its head shaped like the skull of a ram - and took a wild swing at Randyst. The paladin parried the strike, pushing back and making an overhead counter attack that missed the goblin. Another magic missile was launched but the goblin evaded the attack and shifted away from his melee opponent.
He turned to the hanging cage, where the young boy was watching the battle with intrigue. The goblin smirked and pointed his finger towards the rusty old chain holding the cage aloft. Randyst knew what the creature planned: he was going to drop the boy to those spiky stalagmites!
"Nooooooo!" Exclaimed Randyst. "Wizard! Save the boy! I will deal with the creature!"
Herminicle nodded and rushed towards the stalagmite pit while Randyst reengaged with the goblin. Before the wizard could do anything, however, Thork shot a dark missile towards the chain. The chain strained under the stress, the cage swinging wildly from side to side. The goblin cursed, quickly turning its weapon up as the paladin came upon him with fierce resolve.
"Hold tight boy, we will get you out of this", said Herminicle.
The paladin made a horizontal strike and shifted behind the monster. Turning, he saw the wizard in the midst of casting a spell, no doubt to free the boy. Something bothered him, however, and as he brought up his sword to strike at the goblin, he realized what the wizard was doing: he was going to blast the cage!
"Herminicle! what are you doing? Don't hit the cage, the boy will surely plummet to his death!"
The wizard ignored him, blasting loose the chain. The cage, with the boy inside, dropped.
"By Pelor's light! No!" shouted Randyst.
The goblin took advantage of the paladin's distraction, sneaking an attack with a dagger he switched to. Randyst saw the switch, however, slashing his weapon down, cleaving the arm of the goblin right off.
Thork looked in horror as he saw his arm fall to the floor, blood splattering everywhere. He cried in pain and tried to cast another spell at the paladin with his one good arm. The paladin screamed in rage and despair at the death of the boy and ran his longsword right into the monster's mouth. The sword easily slid through the head, sticking out the other side. The sword was soon retracted, the goblin corpse making a wet thud on the floor.
Randyst looked around and found Herminicle, walked up to him and grabbed his collar, pulling him up to his face.
"Damn it wizard! What have you done!"
Something from behind the wizard caught his eye. It was the boy. The boy was alive and, floating? Randyst let go of the wizard and saw that the boy was still in the cage, which floated atop a glowing disc.
"See what I meant when I told you about the usefulness of magic," said Herminicle, crossing his arms and grinning.
Randyst let out a sigh of relief: "That was reckless, but you saved his life."
The wizard brought the disc with the cage away from the pit and set it down slowly. Randyst then struck the lock with his sword, cleaving it easily. He opened the cage and helped the boy out. Meanwhile, the wizard looted the corpse of anything valuable, noticing a talisman of sorts. Unable to identify it, he pocketed the item while the paladin was busy overseeing the boy's health.
This item could be useful, no point in telling him about it, he'd just make me get rid of it thinking its some evil demonic artifact, Herminicle thought.
He walked towards the paladin, who was crouching down and talking to the boy.
"You are very brave lad, you did not seem frightened there. what is your name?" The child looked at the paladin with admiration "My name is Losien sir, Losien Minso."
"Well young Losien," said Randyst, "your mother is very worried about you and sent us to find you. I am Randyst Firestrong, a paladin in the service of Pelor. This wizard who saved you is Herminicle Vortexus."
Little Minso walked up to the wizard and said: "Thank you sir." Herminicle returned his thanks with a simple smile and a slight nod.
Later that day the duo arrived back in Fort Caspien with the boy in tow, his tearful mother very grateful for his safe return. They also informed the Fort Guard of the location of the missing supplies and dead goblins.
The mother invited both heroes to a home cooked meal and an overnight stay in her house. Randyst accepted gracefully, while Herminicle politely refused, saying he had an important task ahead of him.
"Herminicle, why do you refuse the offer of this woman's hospitality? Do you not care for anything other than yourself?" Randyst had asked.
"I have my own quest to undertake, pious one, I need not you to tell me how to operate my life, thank you very much," he answered, frustrated.
"Tell me then wizard, why did you put that boy's life at risk by pulling a stunt like that back there? What if the disc disappeared before he landed on it?" asked Randyst.
"Sometimes in life, one must take risks to achieve ones goal," said the wizard. He walked up to the paladin, giving him a small stuffed dog he had found in the cave. He assumed that it must have belonged to little Losien.
"Remember, Paladin, just because I do not follow the same path as you, does not mean I am an evil, uncaring creature," Herminicle finally said, turning around and walking away.


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Macreme Workshop February 16th!
We are excited to announce that Portland macrame artist Brooke Anderson will be leading a Wall Hanging Workshop on Thursday, February 16th from 6-8pm at Heritage Dry Goods.
This is an introductory class, so don't be afraid to try something new. Bring your gal pals for a fun evening of crafting and shopping. You will receive 10% off all purchases at Heritage Dry Goods during the workshop!
For more details and to sign up visit:
Continue reading


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Winning Year: 1938
Original Publisher:
Terrified that they are about to be sent to an orphanage after the death of their foolishly snobbish Aunt Possit, Peter and Santa set off on a journey in search of an uncle who they have heard travels with a circus. He turns out to be a clown in Cob's Circus which they track down to Bridlington in the north of England. From the moment they arrive in this new and exciting circus world, kindly Uncle Gus looks after them and his caravan becomes their unusual home.
Noel Streatfeild was born in 1895 in Amberley, Sussex, the second daughter of a clergyman. Her older sister was pretty and delicate, her younger sister clever and beautiful - Noel saw herself as the plain one and made her mark by being quite rebellious. She always shone in the plays she and her sisters put on for her father's parish causes. She worked in a munitions factory during World War One and after the war went off to train as an actress. Her ten years on the stage were not very successful but they gave her valuable knowledge of theatre life to use later in her books.
I absoloutely LOVE Noel Streatfeild so it's not surprising I love this book. Although I have to say it was this book that won carnegie and not one such as The Growing Summer.
Offensive? Unsuitable? Report this review.


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ARC (Aerobic Restoration and Capillarity) is the new buzz word around my gym. I've seen or heard of 5 or more climbers recently making this ARC training the focus of their sessions. One even told me that you can't build endurance unless you're training ARC.
I disagree. Strongly.
First off, let me say that ARC training is an extremely useful tool... when used correctly. It's a perfect way to begin a periodized schedule. It's also a great way to cool down a few times per cycle after a workout. When doing ARC training, you can get much more out of it if you train several weak techniques during the workout. Simply put, it's the best training tool going for beginners or a climber embarking on a training plan. The problem is, I have yet to see someone who employs it to it's greatest benefit. I have however, seen several people use it as an excuse.
Now, if you aren't familiar with ARC training, I'll give a brief explanation. When you climb at a high intensity, your tiny little capillaries can't provide enough blood flow to keep muscles oxygenated and keep them from being fatigued. So basically, you need a more dense capillary network to stave off a pump. ARC training is an effective way to build that network. The aim is to climb for 30-45 minutes at no more than 30% of maximum strength. You should sustain a very mild pump throughout the workout. What this does is allow the capillaries to stay fully open while keeping a steady blood pressure on the capillary walls. Your body then adapts to this pressure by creating new capillaries. Now you're an endurance monster, right?
You've now given yourself a useful tool, and the training is really ready to begin. Here's why your ARC training just isn't enough.
1. Your Endurance is Killing Your Power.
It's true. All those boulderers with overdeveloped backs are right... routes WILL ruin their power. The fact is, they are opposites. With endurance climbing, you ask your muscles to use as little energy as possible, though when training power, you're asking your muscles to recruit every fiber that they can. Yes, now you can stay on the wall for 45 minutes on jugs, but why do you fall off the minute you hit 3 smaller holds in a row?
2. Climbing is NOT all Physiological.
In fact, I'd argue that it's mostly NOT physiological. 4 days ago I fell off of an 11b because I was pumped. Today I climbed up it, down it, and back up it without ever getting pumped. Did my physiological endurance improve that much in 4 days? Aww hell naw. I just relearned how to be comfortable while leading with a pump. I got relaxed. I found my rhythm. It was all in my head. What is ARC training teaching you except how it feels to climb without a pump?
3. Your Project is not an ARC workout.
I'm making a big assumption here. I'm assuming that you're training because you have a goal of climbing something hard for you. I'm also assuming that your goal project isn't only 30% of your maximum ability. If it is, you have problems that I'm not licensed to fix. I'm willing to bet that if you picked a project anywhere near your ability limits, then you're going to get pumped, you're going to freak out, and the whole crag is going to hear you screaming "TAKE!!!"the minute you get that crux 3rd bolt clipped.
4. You're Taking The Easy Way Out.
Here's the problem with your easy way out... it's doesn't lead anywhere. Ok, actually it does. It leads you directly to more difficult training, but you're making a U-Turn when the hill gets steep. ARC training is the first step, and a maintenance step after that. I hate (actually I love) to be the bearer of this bad news, but there is NO easy way to getting the most out of your body. It's going to hurt. It's going to mess with your head. And it's going to be the most fun you've ever had. Might as well start now.
Just so that I'm not accused of being completely a Negative Nancy, I'll answer your very important question.... "So where the hell do I go from here?".
Well my friends, click HERE, explore a little, and ye shall be saved.
Happy climbing!