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I believe every relationship has the potential to work. There are some relationships which just flows and don't seem to need too much work while there are others where you sweat, fight and invest your soul and energy to make it work. I have seen the latter case where the couples get married. And these couples wouldn't have it any other way. They love each other dearly and "work" is just part of the deal for them. Also, there are some couples where things are too "smooth" for them and they broke up eventually as the relationship was too dreamy for one or both of them.
Anyhow, when I think of a relationship requiring work, I think of one or two of them being aware of a sticking point between the two of them and making changes or adjusting themselves so that the relationship can flourish. For example, your partner may be a comedian that's in the process of trying to make it big and you are a businessperson who thinks of being practical and getting ahead in life. Both of you seem to have different life directions/goals. For the relationship to work, there needs to be an awareness of it and changes of some kind, say changes to your/your partner's/both of your mindset, spending pattern, etc. These changes are what I meant by adjustments.
Let's see how much adjustment is potentially needed for Sagittarius in a relationship with another zodiac sign a.k.a. Sun sign.
Remember, the above is just one of the many elements to a successful relationship. Every relationship is different and special and can certainly work if both of you wants it bad enough.
All the best,


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Chad Larson, NMD, DC, is one of a handful of doctors who are double Board Certified as a Naturopathic Medical Doctor and a Chiropractor. This unique combination of disciplines affords him the opportunity to bridge the gap between conventional and alternative medicine, allowing him to tailor the treatment for the individual drawing from a broad variety of therapeutic options.
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Latest News
Archaeology has its day at Mounds
You never know what you'll unearch at the sixth annual Archaeology Day from 10 a.m. to 4 p.m. Saturday at Cahokia Mounds State Historic Site near Collinsville.
Sponsored by the Cahokia Archaeological Society, the event allows budding scientists to get their hands dirty by touring excavations, sifting soil from actual digs and washing 1,000-year-old artifacts turned up during the summer excavations. Archaeologists and other specialists will discuss the identification of animal bones, instruments for the remote sensing of subsurface features, plants for food and medicine and Indian rock art.
Visitors also can try their hand at playing an Indian game or throwing spears with an atlatl. If you work up an appetite, there will be food and refreshments, you can enjoy while listening to a storyteller.
All activities are free and open to the public. For more information, call 346-5160 or go to www.cahokiamounds.com.
Free concerts come in threes
HOT BRASS: The U.S. Air Force Band of Mid-America's Hot Brass is offering up a tripleheader of free outdoor concerts this weekend.
The first will be at 11:30 a.m. Friday on Highland's town square; another will be at 6:30 p.m. Saturday at Moody Park in Fairview Heights; and the finale will be at 6:30 p.m. Sunday on the parade field at Scott Air Force Base.
Concertgoers will hear a mix of funk, jazz, blues, soul zydeco, swing, country and pop hits. The band's special guest artist is Tom Coster, a composer and keyboardist with Santana.
COMMUNITY ORCHESTRA: The Metro East Community Chorus and Orchestra also will perform three concerts of music from The Forbidden Mass this weekend.
They are at 7:30 p.m. Friday in room 1109 or Dunham Hall at Southern Illinois University Edwardsville; 7:30 p.m. Saturday at St. Luke's Catholic Church, 301 N. Church St. in Belleville; and 3 p.m. Sunday in Eden United Church of Christ, 903 N. Second St., Edwardsville.
They will perform four slections from Mazart's Requiem and all of John Rutter's Requiem.
Donations will go to the American Cancer Society.
Church picnics in area towns
AVISTON: Have yourself a heaping helping of fried chicken, roast beef and homemade dressing when St. Francis of Assisi parish cooks up its annual picnic Saturday.
Dinner will be served from 3:30 to 8 p.m. in an air-conditioned hal. Mass is at 4. Quilt bingo starts at 6:30. Basket booths, rafles, a country store, face painting and margaritas are also part of the action.
LIVELY GROVE: St. Anthony Catholic Church also has fried chicken on the dinner menu from 4 to 8 p.m. Saturday.
A polka Mass is scheduled for 4 p.m. and another Mass is at 6. A quilt and cash bingo starts at 6:30 p.m. and Polka Connections will perform afrom 7:30 to 11 p.m.
Lively Grove is 4 miles south of Illinois 15 on Illinois 153.
MILLSTADT: Where are they getting all these chickens? St. James Catholic Church will get in on the fried chicken art, too, from 3-7 p.m. Saturday on the church grounds.
A household auction is at 10 a.m., cash bingo strts at 5:30; quilt and cash bingo at 6 p.m. Adult and chidren's fames are planned.
Old favorites help Relay for Life
What do Johnny Cash, Karen Carpenter and Willie Nelson have in common?
They'll share the stage at a Relay for Life fundraiser from 3 to 8 p.m. Sunday at Bretz Wildlife Lodge and Winery near Carlyle. Well, at
The Hope for Tomorrow team will sponsor the event, which also features the Sounds of Harmony barbershop chorus, a DJ, an auction, a wine tasting, nachos and fried chicken.
Tickets are $20 in advance (call Don Koch at 227-8508 or Bill Stock at 233-0198) or $25 at the door. All proceeds benefit Clinton County Relay for Life, which will be held at 6 p.m. Aug. 7 at Central High School in Breese.
Bretz Wildlife Lodge and Winery is 2 miles north of Carlyle on Illinois 127.
Musical, comedies on local stages
Hard Road Theatre Productions continues its musical "Once Upon a Mattress" this weekend in the Highland Elementary School auditorium.
It's a comical, off-beat version of the "The Princess and the Pea" fairytale. The tyrannical Queen Aggravain challenges princesses to pass seemingly impossible tests to show their worthiness to marry her son, Prince Dauntless.
The Highland cast of 30 includes principals Becky Fromme, Mitch England, Mary Knebel, Tom Varner, Whitney Cornick, Josh Noll, Dawna Miller, Ariel Frey and Sarah Henschen.
Show times are 7:30 p.m. Friday and Saturday and 2 p.m. Sunday. Highland Elementary School is at 1800 Lindenthal Ave.
Admission is $9 for adults, $8 for seniors and $7 for children. Seating is general admission. Tickets are available at the door one hour before performances.
For more information, call 654-7748 or visit www.hardroad.org.
"CINDERELLA" -- You might want to nudge your prince to take you to see "Cinderella" this weekend and next at the Miner's Theatre in Collinsville.
Just make sure he has you home before midnight.
The Disney classic begins at 7:30 p.m. Friday and Saturday and Aug. 7-8. Admission is $7 for adults; $5 for kids 12 and under.
"COOKING WITH MARGE" -- The zany comedy dinner show staring Linda Spall will have its final show at 7 p.m. Friday at Fischer's Restaurant, 2100 West Main St. in Belleville.
Admission is $45 per person, including dinner, show, tax and gratuity). For reservations, call Barb at (314)-324-5449. For information, go to www.cookingwithmarge.com.


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Anna Maria Stanhope, the Duchess of Bedford, is credited for the creation of the now world-renowned afternoon tea. In the 1800's evening meals were progressively served later and this left the Duchess suffering from a "sinking feeling" each afternoon at about four o'clock. Initially, the Duchess asked her servants to sneak a pot of tea and a few breadstuffs to replenish herself.
Miles of un-spoilt countryside, tea gardens and wild flowers in spring create the setting for Elgin. Let the region work its magic on you, as you explore little known paths and follow tracks into the forest. We have mapped out trails that suit everyone, so you could go on a challenging walk, stroll along woodland lanes or take a route that offers a glimpse of colonial history.


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Welcome to Whale Watching in Hermanus
Hermanus Whale Watchers in South Africa is a boat-based whale watching company offering an exciting up-close and personal encounter with Southern Right Whales in their natural environment. Southern Right Whale watching season starts in June and ends December.
Boat Based Whale Watching in Hermanus
Hermanus in South Africa is the Land Based Whale Watching capital of the world and every whale watching trip is a unique experience where the sightings vary. Southern Right Whales are the stars of the show during the annual mating in calving season, which starts with the arrival of the bulls in June, closely followed by the females. They will mate during their time in the South African Cape Coastal waters. Pregnant female Southern Right Whales will be the last to arrive and the last to leave with their newborn calves. Only when the calves are fit enough will they swim back to the Antarctic waters where she and the calf will feed on krill, a nutritious rice grain size crustacean.
On a typical whale watching trip, you may encounter Cape Fur Seals, pods of common dolphins or the playful bottlenose dolphins and the endangered Africa Penguins. Depending on the time of the season you may also see migrating Humpback Whales or the resident Bryde's Whales. The Hermanus Walker Bay area also attracts a large concentration and variety of seabirds.
Book an unforgettable whale watching trip today.
Browse through our website to find out more about us, the wildlife in our area, what we have been seeing lately and the trips available.
We look forward sharing your whale watch experience on our next whale trip..
Walbeobachtungen in Süd-Afrika.
Herzlichen Dank a Whale Watchers Hermanus!
Wir waren in Süd-Afrika in Hermanus auf Tour. Wir haben dort die Wale von ganz nahe gesehen.
"The anticipation and excitement were touchable…. standing on the top deck of the boat we were scanning the seas around us for any sign of the familiar V-shaped spray ….. then, right next to the boat in Hermanus, a southern right whale lift its head out of the water are stared at us!! This humbling, awe-inspiring experience created memories for a lifetime…!!" – one of our regular guest comments - Testimonial -


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- This event has passed.
Level II Coach Training Intensive
October 17, 2014 @ 9:00 am - October 18, 2014 @ 5:00 pm$95
Take your coach training to the next level with this Level II Coach Training Intensive. As step two in the Bethel Coach Training Program, this two-day workshop is packed full of interactive coach training sessions designed to augment and build upon Level I Coach Training. The aim and emphasis of the workshop is to provide extensive practice with feedback to build confidence and competence in core coaching skills. Participants will work from the book, Coaching Questions, by Tony Stoltzfus. This book should be purchased prior to the workshop. Completion of Level I Coach Training here at Bethel is a prerequisite for this course.


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At Community Church, we love kids! It is our intention to care for them in the best way we can. They are welcome to join you for services, but they might enjoy what we have planned for them even more.
For infants and toddlers, a family room is located adjacent to the sanctuary and is equipped with nursing and changing areas. A fully-staffed childcare room is located upstairs in the Patterson Family Room for children birth to 3½ years (not potty trained).
For more information, please contact Nursery & Childcare Coordinator Sherry Hoyman at firstname.lastname@example.com.


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Survivor of Stevens crash had no warning
A survivor of the crash that killed five people including former Sen. Ted Stevens told investigators he didn't hear any strange engine noises before the floatplane struck a mountain north of Dillingham.
He didn't feel the plane tilt backward or forward either.
"They were flying along, and then they just stopped flying" said Deborah Hersman, chairman of the National Transportation Safety Board, recalling investigators' first interviews Friday with two of the four survivors.
As workers attempted to remove wreckage from the hillside, Hersman provided new details about the plane's condition, what investigators found on the ground and the flying history of the pilot.


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Bicarbonate of Soda
Bicarbonate of Soda has long been used by athletes to try stave off the effects of lactic acid that is build up during intense periods of anaerobic glycolosis (periods of intense activity lasting 30secs - several minutes).
When lactic acid is produced its function is to inhibit the transfer of energy in muscles and hence reduce muscle contraction and therefore performance.
The theory is that the alkali bicarbonate will lower the acidity levels in the muscles and hence delay the onset of the reduction in performance.
There is some scientific evidence and a good deal of anecdotal evidence that this does have an effect, for races of up to about 7 minutes and also repeated anaerobic repetitions, but you have to ensure the correct amounts are taken and be aware of the side effects.
Side Effects
Many athletes have abandonned using bicarbonate of soda aid their running as they experience side effects of indigestion and diarrhoea, which clearly inhibit performance. It is possible that they are taking the wrong dosage and also that the addition of sodium citrate to the supplement would help this. However, it is a far from uncommon side effect and is something the athlete should be aware of before trying it. NEVER try this for the first time on race day!
There are no known long-term side effects of taking bicarbonate of soda.
The recommendation is that the athlete has 300mg/kg of their mass if they are male and 250mg/kg if they are female. This should be split into 5 parts, starting 3 hours before running and then each dose being at 30 minutes intervals with the last one 1 hour before the effort.
The information here is written by athletics coaches who have read widely into the subject and not a sports nutritionist, so is about gearing your food and drink to the practicalities of running.
Nutrition Topics
- When to Eat
- How to Prepare for Races
- Calorie Requirements
- Losing Weight when Running
- Gaining Muscle Nutrition Advice
- Fluid Intake
- Energy Drinks
- Carbohydrates
- Protein
- Fats
- Vitamins and Minerals
- Fish Oils
- Creatine
- Glucosamine
- Caffeine
- Alanine


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After visiting my blog, visit Justine Hovey's for more crafty fun! The blog hop lasts from 2/29-3/3, and did I mention a prize? The winner will be announced on 3/6! The winner of the blog hop wins one handmade card from each design team member! That's a lot of handmade cards!
So join the fun! Here is my card for this hop, this is the card you will win from me if you are the bloggy leap winner!:
We are also having a contest within our design team for card prizes too! Would you consider voting for my card? Just visit this link So Suzy's Blog and vote for me. Near the bottom of the blog, there are photos of the contest cards with small hearts in the upper right corner. Just click on the heart to vote. Easy! So please vote for me! I'd love to win handmade cards also! :) Thank you!
Here is my card for voting:


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May Wang is a 26-year-old Malaysian currently pursuing her PhD in Business and Management in London, while working as a stylist in Jo Malone London's Covent Garden Boutique. Though little is known about her publicly – she also goes by "Maribel Witwicky" on Facebook – we came across her profile on Instagram and was surprised to find that she has over 114,000 Instagram followers, and 76,000 followers on Facebook. Which begged the question: just who is this mystery woman?
Well, we asked, and she answered.
How would you describe your style?
I love looking smart, but casual; I wear what I feel good. I really admire French chic at the moment. I stock a lot of white, grey, camel, black colour items in my wardrobe, as they're always the best! I love the combination of high street versus high end. Moreover, I know I am quite tall (173cm), but I wear heels very often, probably five times in a week! For my face, I wear chic and polished makeup every day, spending an average 30 minutes for it, and mostly focus on my eyes and lips.
If you could get a flight ticket to anywhere in the world right now, where would you go to and why?
At present, it will be Svalbard in Norway. This place is in between Norway and the North Pole, described as one of the best place to see the Aurora.
What can't you leave home without?
Definitely my phone! I am using Apple Pay so I don't need my wallet. And if I could carry more, it would be my lip balm and lipstick because I need a touch-up every few hours.
When and where were you at your happiest?
When I received a good grade on my Masters Degree in 2013; the feeling was absolutely amazing – all of my hard work paid off in the end! I was literally crying my eyes out when I received the e-mail in Starbucks Baker Street. I was really proud of myself because when I came to London in 2012, I was too shy and I couldn't even speak full sentences of English.
What's on your bucket list?
There are too many to list! Get a secret piercing, learn a foreign language, drink 10 different cocktails, live on a beach for months, own something from Van Cleef & Arpels, wear a Patek Philippe… the list goes on.
When was the last time you went "Wow, that was an awesome date"? What happened then?
My boyfriend took me to Somerset House for ice-skating last winter. Somerset House is just priceless; without a doubt this place is the best outdoor skating experience in London. They have the most beautiful ice rink, and the Christmas trees overlooking the rink were wonderfully decorated – it really got me in the romantic and wintery mood.
What advice would you give to guys when asking a girl out?
Be confident and keep your chin up. Do make sure you have a list of questions in your mind to gauge her level of interest. Aside from that, I think rejection is normal, so guys: Be chill about rejection ^ ^ Haha! It's not the end of the world.
Images courtesy of May Wang
Follow Her
Instagram: @maybe_iamawesome
Facebook: Maribel Witwicky


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Felipe Castaneda def. Tony Valdez via 8th rd TKO 01:34
8) Men come out and trade. Probably a bad game plan for Valdez. Valdez cuaght with four big shots. And another huge flurry from Valdez. Castaneda is on a rampage Valdez stumbles around the ring. Valdez is holding strong. Ref stops fight after a huge exchange Castaneda landed some huge powershots!
7) Veteran move by Valdez steps on Castaneda lead foot and lands straight right. Valdez now stalking Castaneda around the ring. Hip shot left hook from Castaneda lands flush. Castaneda with a little bit more urgency. Valdez now against corner men are throwing cautiously and not landing big. Castaneda is allowing Valdez to rest by not throwing as he stalks him around the ring. Valdez lands lunging right and is countered with a left.
6) Valdez comes out fresher and lands stiff lefts and body shots. Castenda isn't getting time to set. Valdez throws before Castaneda has time to think about punching. Valdez a lot more aggressive in this round. Valdez with an over the top right misses with left but lands another right. Castaneda tries to block Valdez's pittypat punches, not strong but they are scoring nonetheless. Castaneda comes back with stiff lead lefts of his own. Valdez' hands are below his waist. Castaneda appears tired.
5) Castaneda trying to establish the left jab again. Valdez staying in the pocket now. Valdez now looking to counter Castaneda. Castaneda being patient this round and countering very effectively. Valdez gets caught lunging in. Valdez' legs aren't as strong. Men trade shots with Valdez coming out on top of the exchange with a big straight right. Huge right from Castaneda, Valdez responds with a left of his own.
Castaneda in a very close round
4) Castaneda comes out busier with his jab. Valdez contemplating moving in and out because of it. Valdez dropping his hands a little in this round. Valdez trying to make his way into Castaneda's body with his shoulder. Big over the top right for Castaneda punches Valdez back. Castaneda lands another big punch. Valdez is starting to retreat, looks a bit tired. Castaneda does not take advantage instead waits to counter with right uppercut. Valdez is not throwing with power this round.
3) Tony being very aggressive 20 lightpunch combo, literally, with no response, his last 8 punches missed. Crowd chants TONY TONY! Castaneda standing straight up, no fluidity in his movement. Tony get's caught by a counter right hook as he walks toward Castaneda, Valdez takes a moment to blink several times. Valdez so much more fluid, is giving Castaneda problems. HUGE right cross from Castaneda sends Valdez to the ropes but he stays up.
2) Valdez is not looking to trade with Castaneda. Valdez so far is pretty elusive. Lead left followed by two consecutive left hoos for Tony Valdez. Castaneda trying to lead Valdez into a corner but Valdez easily walks out of it again. Valdez misses wide and Castaneda makes him pay with a left right hook combo, Valdez responds with a strong left of his own. Men and trading straights. Valdez trips over Castaneda, no knockdown. Two straight right hooks from Castaneda, Valdez plays his game and stays in the corner. Valdez comes back strong forcing Castaneda back and finishing round with clean 5-punch combo
1) Valdez start out strong, sticking and moving. Castaneda stuff him with a solid left hook. Castaneda playing the countering game waiting for Valdez to make a mistake. Valdez is in and out though. Valdez lunges in and is caught by a fading right hook. Valdez responds walking around rings and delivering three bodyshots. Castaneda stalks Valdez around the ring. Valdez measure with with a his lead left hand. Men exchange in the corner but it's Valdez that ends the round strong.
Co-Main Event:
Brandon Holmes def. Daniel Salinas via 2nd rd KO 01:15
2) Salinas comes out and forces Holmes to the ropes. Holmes respond with two huge hooks, the men separate and Holmes lands a huge five punch combination topped off by a big left hook that floors Salinas. Men move to the ropes where Holmes unleashes a devastating left hook, right hook combo Salinas eyes are gone Homes follows up with a punishing left hook that KOs Salinas!
1) Salinas does in with very low stance and flares lead left jab out but draws all air. Holmes waiting to throw. Salinas catches him off balances Holmes appears to trip on Salinas foot as he catches a right hand and almost falls, pretty athletic not fall there. Salinas is clinching Holmes and is finding open shots in the inside. Holmes brings action back to the center where he lands a flush right and left hook. Salinas waits for Holmes to come in and counters him with a right to end round.
Angelo Leo def. Brian Garcia via MD 40-36×2 38-38
4) Leo starts by shooting a huge right hook from his hip. He has Garcia against the ropes an unleashes a huge flurry. Break in action, the referee asks the ringside physician to look at Garcia's cuts. Garcia comes out very energized but consecutive straight left jabs from Leo end that. Leo is determined to end fight but in the process has to gain breath against the ropes. This give Garcia an in but he's tired and can't follow through on punches he lands to Leo's face. Leo is extremely composed he dances around ring stops and lands a straight left jab followed by a right cross, Garcia didn't even react to the punches.
3) Leo moving well around ring whenever he decides to use footwork. Leo now stalking Garcia around the ring. Leo lands big uppercut with straight right and steps out. Beautiful comobs by Leo force Garcia back into the ropes. Garcia cut above right eye and out of nose. Leo punches now landing with a thud, he's finally sitting on them, he's finding it easy to do with a slower Garcia. Left hook right hook combo from Leo, Leo looks to finish the fight but is interrupted by the bell.
2) Garcia looking to wear down Leo against the ropes. He's much more muscular his short punches on placing his weigh on Leo is slowing Leo down. Neither guy has really hurt each other but are working for every punch. Leo body work finally comes back. Garcia is now failing to follow through on punches, he throws a wide left and is countered with a cross-right from Leo.
1) Men start off head to head, literally. Interior work by both. Leo works Garcia int he ropes and lands several body punches. The speed is clearly on Leo's side. Good head movement demonstrated by Leo. Garcia is lacking a jab and is looking to force action in the interior whenever he gets the chance. Tried to bully Leo against the rops but his shots are light. Leo easily works out of the ropes.
Brandon Salazar def. Patrick Holmes Jr. via 3rd TKO 02:45
3) Salazar tries to force action on the inside, Holmes counters with a bit of dirty boxing, ref immedeiately breaks them up. Salazar shows a little more aggression and gets Holmes in his own corner with a mean four-punch combinations to the head. Holmes flails punches in defense. Holmes rides ropes trying to recuperate; still has his legs. Salazar attacks Holmes in a neutral corner and lands a huge five punch combination, Holmes mouthpiece almost comes out; he is turned sideway. Referee jumps in to stop the action. Holmes appeared to be hurt but able enough to continue but the ref felt the last combination was big enough to stop contest at 02:45.
2) Salazar muay thai stance is leaving punches right up the middle open. Salazar throws three punch combo that lands. Holmes doing a good job of countering with one-time straight rights. Holmes now bleeding from nose. Holmes is leaving chin out but reflexes are quick. Big straight right from Holmes backs Salazar up. Slower pace this second round but still entertaining. Holmes has shaken off any cobwebs he had from the first. Salazar a little for patient. Men now trades straights against the ropes.
Holmes 10-9
1) Both fighters come out in a wide stance. Holmes demonstrating great head movement just avoided three straight rights. Holmes throwing a lot of power rights and is leaving himself open. Holmes caught with a huge right! He's staggered! He holds even after the ref break. Salazar is leaving left lead jab hanging throw big right cross and is countered by a HUGE right cross from Holmes that puts him down. Salazar gets up and drops big right that momentarily stuns Holmes. Holmes now starts using jab and manages the middle of the ring. Salazar reluctant to punch to end the first.
Holmes 10-8
FOY Candidate
Antonio "Tone" Martinez (137.4) vs. Matthew Baca (138.4)**
Matthew Baca vs. Antonio Martinez DRAW 39-37 Martinez, 39-37 Baca, 38-38
4) Martinez walks down Baca to start round. Baca responds and now dancing around ring. Huge over the top right for Martinez! Action resumes Baca dives on Martinez to the corner. Martinez now catching a slower Baca with 1-2 combos.. Baca goes to the body with a big left. Martinez double left hooks now. "Finish strong Matt!" exclaims his corner. Baca looks fresher in final half. Baca drops a five punch combo. Even
3) Men are now putting on a show in the 3rd. Maritnez hooking with a hooker and is losing that battle. Baca goes for wide right hook and gets countered with a huge left. Martinez now building momentum, Baca is slowing down. He goes back to body momentarily slowing Martinez. Martinez responds with a straight left and Baca rides him to the ropes. Baca traps Martinez in his own corner and works the body. Great round of action, Baca won last 30 seconds but Martinez had his best round. Martinez
2) Baca boxing at a distance now. Martinez is throwing over Baca's head really strange. Martinez now having success with back against ropes catching Baca with short shots upstairs and downstairs. Martinez bleeding from mouth. Baca's having great success long to mid range when he's up close Martinez has success with those short shots. Baca
1) Both men come out slugging. Baca gets best with huge bodyshots. Martinez grabs an arm a bit overwhelmed. Straigh right from Martinez settles Baca back momentarily. Martinez' left side of body is extremely red. Martinez tried a big of roughhousing as his back is against the ropes. Baca


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Welcome to the Forums - Portal of Robotics and Artificial Intelligence.
The robot is equipped with a close human-machine relationship
Today, 07:34
MBUX, smart in-car assistant, Daimler AG, Stuttgart, Germany
Today, 18:16
20th November 2019, 23:16
In the future, hackers will use robots to kill their owners
14th November 2019, 08:03
Spectacles, sunglasses, which record video snippets, Snap, Inc., Venice, California, USA - spectacles.ai
14th November 2019, 03:33
Knightscope, fully autonomous robot to predict and prevent crime, Knightscope, Inc., Sunnyvale, California, USA
18th November 2019, 21:18
Roam Elevate Ski XO, powered exoskeleton, Roam Robotics Inc., San Francisco, California, USA
20th November 2019, 00:51
GeoDrone project, Dynamic Parcel Distribution DPD, Aschaffenburg, Germany
14th November 2019, 21:43
Ganker, fighting robot, GJS Co., Ltd., Shenzhen, China
20th November 2019, 17:03
Today, 18:24
14th September 2019, 00:11
1st November 2019, 05:47
Yesterday, 00:27
Scouting robot, EcoRobotix, Zurich, Switzerland
18th November 2019, 20:40
Microsoft Power Platform, Microsoft Corporation, Redmond, Washington, USA
6th November 2019, 16:04
Today, 08:23
Thematic domain names for sale
Today, 10:27
Stadia, cloud gaming service, Google Inc., Mountain View, California, USA
19th November 2019, 20:17
ReAgent, applied reinforcement learning platform, Facebook, Inc., Menlo Park, California, USA
31st October 2019, 17:19
Jimu, educational robot kit, UBTECH Robotics Corp., Ltd, Shenzhen, China
30th October 2019, 15:26
6th November 2019, 02:55
Microsoft Azure, cloud computing service, Microsoft Corporation, Redmond, Washington, USA
8th November 2019, 03:38
28th August 2019, 19:12
Yesterday, 19:29
Autonomous systems platform, Microsoft Corporation, Redmond, Washington, USA
5th November 2019, 02:24
Can anyone become a data scientist?
9th February 2019, 09:25
20th November 2019, 19:18
Thematic domain names for sale
20th August 2017, 07:42
10th November 2019, 19:22
18th March 2018, 20:27
CarLa, charging robot, KUKA AG, Augsburg, Bavaria, Germany
11th November 2019, 01:50
"Digital Transformation: Survive and Thrive in an Era of Mass Extinction", Thomas Siebel, 2019
19th November 2019, 22:29
Robot kills man at Volkswagen plant in Germany
4th November 2019, 07:17
12th November 2019, 23:01
Yesterday, 00:35
"Terminator", thriller sci-fi films, James Cameron, Jonathan Mostow, McG, Alan Taylor, 1984-2015, USA
13th November 2019, 04:31
9th October 2019, 02:00
Real-time emotional intelligence, Cogito Corporation Inc., Boston, Massachusetts, USA
6th September 2019, 21:27
Five Closely-Guarded Vancouver Mortgage Broker Secrets Explained in Explicit Detail
12th November 2019, 12:54
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Thoughts on deashibarai. Let me know how your mileage varies...
- Deashi barai is an excellent low-force, low-commitment footsweep I've seen it thrown as ippon or as takedown by both beginners and experts in both judo and bjj. When thrown as a delicate timing throw, it sets up every other throw in the syllabus, but it is also quite effective on its' own, when it does fail it often leaves uke in a worse position, and it is quite difficult to counter.
- Deashi is the first of the gokyo (Kodokan syllabus) for a reason. It teaches you timing lessons you need to understand to do the rest of the gokyo. It sets up every other thing in the system. So potentially you can build a deashi-anything combination.
- You really don't have to sweep very far - certainly don't sweep their leg up into the air. I tend to sweep just far enough to place all four of our feet in a line, then do the rest with a little hand twitch toward my chest. If they don't fall, that's ok, but more often than not, uke will spazz out and pick both feet up off the ground. From there, it's all downhill!
- But if you do sweep their foot into the air and they don't come off their other foot and fall, try kosotogari - sort of a backwards footstop action as they are about to put their foot back down.
- Watch out for tsubamegaeshi - especially if you try to execute this sweep as a power stroke through their leg.
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Both ingredients are natural with nutritional value. Its roots are lost in antiquity confection. Honey and sesame were components of the ancient Greeks diet, which had developed various dishes to improve nutrition. The common name of pasteli in ancient times was "sisamis".
The pasteli (SISAMI) was a symbol of fertility and offered to weddings as a welcome to the guests, and to the bride after the ceremony, as she was crossing the threshold of her new house. The sisamis name prevailed until the middle of the Byzantine period.
The pasteli has a history of at least 2500 years and since then it has been established as nutritious food.
Traditional preparation
The basic preparation of pasteli is: The honey is boiled in a special shallow pan with a large surface and is skimmed when it starts to boil. When the honey thickens, sesame is added under continuous stirring to prevent the mixture from sticking.
When finished cooking, the mixture is spread over a marble surface or a special canvas smeared with sweet wine or almond flavored oil. Once the mixture has cooled down open it to about 1/3 of an inch thick and cut into pieces. Of course the recipe varies by region (eg in Sifnos they do not skim the honey).
Because the pasteli was prepared with only two raw ingredients, the process is simple. The secret of success lies in the quality of honey and sesame, the mixing ratio of the two ingredients and the good bonding between them.
The pasteli is chewy if you add more honey and crispy if you add more sesame.
A common method to determine whether the components are bound together is to pour a little mixture on a plate. If the mixture is ready it will not stick on the plate.
The pasteli ingredients
Honey is produced by bees from nectar or the honeydew from various plants. Thus making it one of the most natural nutritional foods. Read more about honey
Greece ranks second in the worldwide consumption of honey, 2lb per capita consumption per year. First is Germany with 3lb annual consumption per capita. The total honey production in our country is around 20,000 tons, of which about 60% is sold as pure honey and the remaining 40% processed. A significant percentage of honey is supplied to large industries which produce other products that contain honey, such as pasteli, nougat, Halva with honey, and yogurt.
Sesame was one of the first oleaginous plants (sesame oil) cultivated by man. It comes from eastern Africa and cultivated in most tropical, subtropical and southern zones of the world and in Greece. Today unfortunately it is not cultivated in our country but instead it is imported.
Reference to Ancient Greece:
Many ancient texts show that the sesame was cultivated in ancient Greece. Ancient texts states that sesame was used for production of pasteli or pastries.
Research has proved that the pasteli has many beneficial properties. The same applies to sesame oil, tahini and chalva.
According to a study which was completed and published contacted by the Aristotle University of Thessaloniki sesame and its products, have anti-aging, anti-cancer, antihypertensive, and other benefits.
Here are also some of the other benefits
1. Reduce blood cholesterol levels.
2. Enhance the proper functioning of the immune system.
3. Prevent cataract.
4. Assist in the treatment of diabetes.
5. Protect against atherosclerosis and hypertension.
6. Prevent or slow chronic diseases.
7. Contribute to the proper functioning of the liver.
8. Have anti-aging and anti-hypertensive properties.
Source: study by ETAT SA
Magazine Food & Beverage
EPET II research and technology program


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An unusually large decline of nearly 5 percent in the pricing of TV panels caused by anemic demand helped drive down overall prices of large-sized liquid crystal display (LCD) panels in September, according to an IHS iSuppli LCD PriceTrak report from information and analysis provider IHS.
The 4.9 percent contraction in LCD TV panel pricing was the steepest in at least 12 months, and also was the second straight month of decline greater than 4 percent. In August, LCD TV panel pricing fell
4.3 percent following dips averaging less than 1 percent in the prior four months. For an even bigger drop than that in September, one would have to go back a full 12 months to the same time last year, when LCD TV panel prices dived 5.2 percent in September 2010. The price reductions on TV panels were continuing in October as the end of 2011 approached.
The weak pricing in the TV sector meant that overall prices remained depressed for large-sized LCD panels, including those used for monitors and notebook computers. Average LCD panel pricing for all three sectors in September was 3.8 percent lower than in August.
Slumping demand in Western Europe and North America are primarily to blame for the poor performance of LCD TV panels, IHS believes. Given the already faltering economies of those regions and the threat of a double-dip recession looming, global LCD TV shipments continue to suffer, impacting the TV panel market especially hard.
Also contributing to the depressed market for LCD TV panels was the China factor. Panel purchases in China are mostly completed by August in anticipation of the country's National Day celebrations in October—a weeklong event that normally sees a surge in consumer purchases, including those for televisions. The next big splurge by China on LCD TV panels is not expected until the end of the year, timed to coincide with Lunar New Year festivities in late January of 2012.
To boost LCD TV panel demand and entice TV manufacturers to buy more, panel suppliers now are offering very aggressive prices for the forthcoming Black Friday and Christmas holiday buying season in the United States and Europe—a traditional time of strong retail sales. But because TV brands also are setting highly competitive pricing to lure consumers in the weeks to come, that in turn has ratcheted up pressure on LCD TV panel manufacturers to lower their prices, especially on panels featuring the popular light-emitting diode (LED) technology. With pricing on some TV panels reaching the cash-cost level, panel manufacturers are cutting utilization rates in their fabs and trimming inventories in order to reduce oversupply and restore balance to the panel market.
September pricing for 40- and 42-inch LCD TV panels fell by $10 to $15 on average and was down a smaller 5 percent for 46- and 47-inch panels. Rates continued to drop in October, though at lower levels, and U.S. retailers are expected by Black Friday to offer 42-inch LCD TV sets featuring full high definition and light-emitting diode (LED) technology at less than $400.
Unlike TV panels, monitor and notebook panels saw September pricing fall more moderately, in both cases dipping 1.7 percent from their August levels. Monitor demand fared better in the corporate segment worldwide than among consumers, who stayed more focused on mobile devices like smartphones and tablets, such as Apple Inc.'s iPhone and iPad. Notebook panels, however, continued to struggle with weak numbers, and back-to-school sales were disappointing—again because of inroads made by smartphones and tablets into consumer households.
Overall large-sized LCD panel pricing continued to fall by another few percentage points in October, but pricing is expected to stabilize somewhat in November and December due to controlled panel production.
Learn More > TV Panel Prices Fall Sharply in September


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Lessons Learned from the OpenSSL Hack
The "good news" is that, unlike the vulnerabilities with GnuPG and similar strong encryption, this attack was just a classic brute-force compromise of the web hosting platform and doesn't have anything to do with the widely-used OpenSSL software, itself (a significant percentage of websites use OpenSSL for browser security).
The article mentions that the checksums of the OpenSSL software, hosted independently on GitHub, appear unaffected. The article also mentions, in brief, how the attack was effected: bad passwords.
And that's really the bad news. For all the cleverness of the mathematicians and software engineers and hackers in putting together first-rate software, their website (hosted on a second-rate, discount provider in Sweden) was compromised either because of poor-quality passwords and/or inadequate password change policies on the part of the OpenSSL team or, at least as likely, loose security and the same lack of good policy and procedure on the part of the webservice provider.
The most likely scenario is an ex-employee or contributor to the project leaked access codes, performed the break him/herself, or simply didn't guard his/her information carefully enough. To this day I can still remember the root / administrator (privileged user) account password for *all* the Unix, Linux, Windows, servers that Loudcloud had deployed for *all* its customers around the world.
It wasn't a bad password — more than 8 characters long, upper and lower case, numbers and symbols, no repeated characters — but it was also highly memorable (especially after typing it a few dozen times per day!)… and it was never changed.
That was 13 years ago. Of course, Loudcloud is no more and all the assets have changed hands several times… but at times like this I wonder if I could send myself a pair of shoes from the Nike website or improve my stock portfolio through one of the management companies we used to host.
I'm oversimplifying greatly — there are still plenty of security hurdles to get around before one even has an opportunity to use a secret password or other privileged information — but this attack on OpenSSL.org is yet another demonstration of not only the possibility of compromise but that the solution is not in the technological complexity but in the human factor.
Far more "nerve rattling", IMHO, is the author's conclusion about OpenSSL.org being "hacked": "Users should demand a thorough autopsy. And while they're at it, they should demand that the official maintainers of both the PHP Web scripting language and the Linux operating system kernel make good on promises to provide autopsies of serious compromises on their own servers."
First, a logical problem: a project's website usually has nothing to do with the software that the project provides, even if one can download the software "from" the site (which is typically a redirect to a different site on a different system with different security). To confuse this issue contributes to a poor, fear-based understanding of what the issues at hand actually are.
Now, I grant that a "hack" enabled by bad passwords on a cut-rate service provider is pretty embarrassing for any such project. *BUT* the purpose of Free and Open Source Software (FOSS), its very reason for existence, is for the *user* of the software to be able to find and fix bugs, rewrite the software to suit one's own purposes, contribute back to the community, re-sell the software as part of a larger package.
In short, the onus of the responsibility for the use and quality of the software is on the *user*! This is the direct antithesis of the classic software-company model where the user is legally *denied* the right to responsibility for the software and must rely on the the vendor for fixes and improvements — which may or may not be at all what the user desires but is paying for in any case.
The middle ground also exists: there are companies that write or customize [FOSS] software, fix critical bugs, according to the desires of their customers. Of course, this middle ground can *only* exist in the FOSS environment, since commercial software cannot (legally) be modified.
Many independent studies have found that, generally speaking, FOSS tends to be of higher quality than commercial software. That is, it performs more efficiently, is more extensible. Not to mention that FOSS can always be highly customized by a sufficiently motivated user.
That said, commercial software, especially from virtual monopolies such as Microsoft, Apple, and, increasingly, Google and other online / cloud providers, has one significant (in the eyes of many users) benefit: it tends to be much more consistent between products, general reducing the learning curve between *how* one interacts with different pieces of software on the same system.
(Microsoft, oddly, tends to scuttle this benefit by introducing significant and often-unnecessary changes between major releases… though this just seems to be proof that their customer base is comprised largely of victims of Stockholm's Syndrome.)
This benefit, of course, is also its own limitation; all of the vendor's software *has* to work "the same" (from a user management perspective) or the user will perceive it as being broken. With FOSS, on the other hand, a higher learning curve between software packages on a single system also allows for greater flexibility on both the part of the designers and for the implementers / users.
The problem in both arenas that is becoming evident is that, with a general desire to make increasingly large and complex software "easy to use", most software packages come riddled with security holes: not flaws in the design exactly, but simple configuration problems and un[dis]closed "back doors" because the royal We have been tricked into believing that, because the software was easy to install or get running, its functioning is also easily understandable and highly comprehensible.
This *is* the fault of the user, regardless of what software s/he is using. But, too often, the user doesn't want or can't afford to take responsibility.
In any case, the developers of and contributors to FOSS are rarely paid directly for their [coding] efforts (many of them do make good livings via consulting, publishing definitive books on the use of their software, or being employed by a company that encourages or supports FOSS projects).
Although the FOSS community, including the original developers of any given project, are often highly responsive to problems, concerns, bug reports, the simple fact is that *all* FOSS is released with a legal caveat along the lines that the software is not guaranteed for any merchantability or fitness for any purpose.
It has to be that way. The end-user has to take the responsibility. The tendency to actively deny this responsibility and encourage others to do so as expressed by the author of the article is at least as frightening as the bad password procedures that led to him having something to write about in the first place.
About the Author: Walter Davies is a Unix Systems Engineer, musician, and scifi buff with 20 years of high-tech industry experience. He has survived for the past 8 of those years without a cat.
Editor's Note: The opinions expressed in this and other guest author articles are solely those of the contributor, and do not necessarily reflect those of Tripwire, Inc.
Related Articles:
- Target Data Breach: Millions of In-Store Credit Cards Affected
- Target Data Breach: How to Perform Early Detection of a Distributed Attack
- Proactively Hardening Systems: Defining the Attack Surface
- Stolen Target Credit Cards and the Black Market: How the Digital Underground Works
The Executive's Guide to the Top 20 Critical Security Controls
Tripwire has compiled an e-book, titled The Executive's Guide to the Top 20 Critical Security Controls: Key Takeaways and Improvement Opportunities, which is available for download [registration form required].
Definitive Guide to Attack Surface Analytics
Also: Pre-register today for a complimentary hardcopy or e-copy of the forthcoming Definitive Guide™ to Attack Surface Analytics. You will also gain access to exclusive, unpublished content as it becomes available.
Title image courtesy of ShutterStock


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Viva Lewes Cover
Mary Fellows Designed the May cover of Viva Lewes. The Viva theme was Keeping it Clean and here it is…
Viva Lewes said "Once we'd decided on a theme of keeping it clean, we felt that, because of her punchy graphics and the retro packaging feel of her designs, Mary Fellows was an obvious choice of cover artist."
It was exciting! I love drawing pictures. I took the shapes from an old OMO package, then made the words relevant both to the magazine and a soap packet. I always prefer to work in two colours when i'm screen printing, but since this isn't a screen print, its drawings i've scanned, i decided to add some extra yellow, orange and blue.
And it's not the first time Mary has been the Cover Artist for Viva!
I also used a few elements from my Christmas Viva cover – such as the background graph squares.


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Today is November 8th, and it is a BIG Day! Why is it a big day? Because it's time for the November issue of PANDAS Sucks' series "GR8 ADVOC8 on the 8s." I'm sure everybody will be tuning into the blog to see what's up for GR8 ADVOC8s this month. What else could be bigger than that? 🙂
For those of you not already in the know, the GR8 ADVOC8s on the 8s series focuses on ways that YOU can easily Advocate and spread Awareness and Understanding about PANDAS/PANS all year long. I usually give 3 suggestions or actions (I'm calling them PANDActionS now). Mostly the items don't take much effort but can have a big impact…especially if enough of us start participating. But as always, only do what you really want to do. Never let anybody, including me, guilt you into feeling that you need do PANDAS/PANS Advocacy. Never.
November is Gratitude Month. We could all do with some specific time set aside to be grateful for good things. For November's GR8 ADVOC8 on the 8s, I'm going to recycle a few previous suggestions that deal with gratitude and saying thanks. Yes, PANDAS Sucks…it sucks big time! But sometimes good things happen between all of the things that suck. We need to be sure that we can keep our eyes open to those things so we can realize when they are happening and be thankful for them.
1. Send a note of appreciation to your state's Governor if s/he proclaimed October 9, 2016 as PANDAS/PANS Awareness Day. Heck, why just stop at your state if it participated in PANDAS/PANS Awareness Day? You can send a thank you to all of the states that made proclamations! Here's the final tally for 2016…23 states: Kentucky, Illinois, Massachusetts, Missouri, Arizona, Michigan, Connecticut, New York, New Jersey, New Hampshire, Virginia, Nevada, Delaware, West Virginia, Indiana, Ohio, Wisconsin, Rhode Island, Minnesota, Oklahoma, Missouri, Washington, Maine. And our neighbors up North: Saskatchewan, Canada. Plus Miami, FL. Woohoo! Y'ALL ROCKED IT!!! A few other states applied, but proclamations were not granted…some states just say no. Write and say THANK YOU to the Governors who said yes. Find the state office info here.
How is this PANDAS/PANS Advocacy? Saying thank you is always a nice thing to do. Thanking somebody, especially a public official, for helping you in your efforts of PANDAS/PANS Advocacy is GR8! (See what I did there?) And yes, it might have been a staffer that actually di the work to get the proclamation declared. Check with your state's point person and get the staffer's name and thank him/her too! Sending these thank you's also puts PANDAS/PANS on the government official's mind again. It can make later efforts for PANDAS/PANS Advocacy at the state level easier. Baby steps…it's always baby steps.
2.Send a Thank You to somebody that has gone above and beyond in helping support your family's journey in PANDAS/PANS. This might be a doctor or a coach or a teacher or a family member or a friend. Okay. Now, get out a piece of paper or open your email app, and send that person a Thank You note. It doesn't have to be long, but write it from the heart to tell them how much you appreciate all that they have done for you and your child. It can actually be somebody that maybe hasn't helped you personally but helps others in the PANDAS/PANS Community. Showing gratitude to all the doctors and researchers and official advocates/groups/organizations is only ever going to be a good thing. That picture shown is actually a stack of thank you cards that I started filling out today. (The trick is to finish them all and track down addresses and mail them! Yes I can!)
How is this PANDAS/PANS Advocacy? Everybody likes to get a thank you. For folks that help out PANDAS/PANS children and families, it is nice when they are acknowledged. It only takes a few minutes to show somebody that you noticed their caring and compassion and appreciate it. It's a way to find a sliver lining in PANDAS/PANS too. You'll get to feel good too when you send that email or drop that letter in the mail. Showing your gratitude will go a long way.
3. Submit a PANDAS Silver Lining you've found. Yes, PANDAS Sucks, and we talk about that A LOT!…but good stuff still happens too. You might have to really look for it, but don't lose sight of it. The new series "Your Words: PANDAS Silver Linings" encourages us to "Find the Light in our Dark Days." Click here to make a submission. It might be a life lesson, your favorite quote or scripture, or a poem that buoys your spirit. Or maybe you met somebody awesome or found your own strength or your child had made huge strides in recovery. Or you might have just had a great day and want to share the details. I asked about PANDAS Silver Linings on the recent survey and got 125 responses. Some of these folks were saying that they had not found any PANDAS Silver Linings yet, and I get it. I struggled with this a lot too, and I still do sometimes. My hope is that for all of the awfulness that everybody deals with inside the belly of the beast that is PANDAS/PANS that there are awesome things that happen too in order to give you some relief.
How is this PANDAS/PANS Advocacy? You'll be helping yourself AND helping others when you consider and share your PANDAS Silver Linings. You never know when your words of encouragement will give light to somebody's darkest day. I publish the PANDAS Silver Linings periodically. Feel free add your good stuff to the list. You never know who will read what you share and have it resonate. And I will point out that you can also read the PANDAS Silver Linings to help in drawing your own strength. <3
Update on Last Month:
You can read the October GR8 ADVOC8 Post to see the suggestion (usually there are 3 but October had only 1 suggestion).
1. Complete the State of the PANDAS/PANS Community Survey. For October, the only advocacy suggestion was to complete the State of the PANDAS/PANS Community. Over 250 of you completed the survey from all over the world. I'll be tabulating the results and reporting them soon, but it will be after the blog redesign I'm getting ready to do. Some of the results are going to be shared with folks that need to know them…and shared very soon. <3 And THANK YOU for all of the "PANDAS Sucks Because…" reasons and "PANDAS Silver Linings" and blog post ideas! And if you indicated that you were interested in writing a guest blog, I'll be in touch at a later day. Thank you to everybody that participated to help tell Who We Are as the PANDAS/PANS Community and to get your voice heard. (******NOTE: THE STATE OF THE PANDAS/PANS COMMUNITY SURVEY WAS CLOSED TO RESPONSES ON 10/31/16. THANK YOU FOR YOUR PARTICIPATION! THE RESULTS WILL BE TABULATED AND REPORTED IN A FUTURE BLOG AND IN OTHER PROJECTS.******)
In the spirit of gratitude, I would like to send a shout out to all the PANDAS Sucks Readers. I'm grateful for you and want to say THANK YOU for all of your support and participation. You are all one of my PANDAS Silver Linings. I'm happy to operate this blog for such an amazing Community as a means to tell our collective story to the world. There's nothing like connecting with other PANDAS/PANS Parents. I met some of y'all at the PANDAS/PANS Conference last month. You all ROCK!!!
Tell us why YOU think PANDAS Sucks. Click here.
We post these reasons in a blog series.
Have YOU found a PANDAS Silver Lining? Click here.
Want to send a message to Sarah? Click here.
Sarah Jane Alleman is a PANDAS Mom to her awesome son, Jesse. She spends much of her time on Facebook, making to-do lists, and listening to music, especially Depeche Mode. She drinks a lot of coffee, likes a good red wine, and has been known to hide chocolate in her pantry. Sarah really thinks PANDAS Sucks (the autoimmune disorder, NOT the bears!). PANDAS Sucks exists to tell the collective story about PANDAS/PANS. Sarah wants to empower other PANDAS Parents and let them know they're not alone. She is also the Director of Kentucky PANDAS/PANS Support, which strives for more awareness, support, and understanding of PANDAS/PANS. Sarah was a Parent Contributor to the book "PANDAS and PANS in School Settings." Find PANDAS Sucks on Facebook, Instagram, Twitter, and Pinterest.
Note: Please do not ask for doctor referrals or specific medical advice. This blog/web site is for info and support purposes only. I'm not a doctor.


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GSBS Dissertations and Theses
Publication Date
Document Type
Doctoral Dissertation
Academic Program
Cancer Biology
Molecular, Cell and Cancer Biology
First Thesis Advisor
Michelle Kelliher, Ph.D.
Receptor, Notch1, Precursor Cell Lymphoblastic Leukemia-Lymphoma
Gain of function NOTCH1 mutations are common in both patients with T-ALL and in mouse models of the disease. Inhibiting the Notch pathway in T-ALL cell lines results in growth arrest and/or apoptosis in vitro, suggesting a requirement for Notch signaling in T-ALL. Therefore, we sought to examine the role of Notch1 signaling in both premalignancy and in the maintenance of leukemic growth. Using a murine model of T-ALL, in which expression of the Tal1 and Lmo2 oncogenes arrests thymocyte development, our preleukemic studies reveal that Notch1 mutations are early events that contribute to the clonal expansion of DN3 and DN4 progenitors. We also demonstrate that progenitors are maintained within the tumor and are enriched in leukemia-initiating cell (L-IC) activity, suggesting Notch1 may contribute to L-IC self-renewal. By studying the effects of Notch signaling in murine T-ALL cell lines, we also demonstrate that Notch1 promotes the proliferation and survival of leukemic blasts through regulation of Lef1 and the Akt/mTOR pathways.
Given that T-ALL cell lines are dependent on Notch signaling in vitro, we investigated the effects of Notch inhibition in vivo. We provide evidence that Notch1 can be successfully targeted in vivo and that Notch inhibition, with γ-secretase inhibitors (GSIs), significantly extends the survival of leukemic mice. We also demonstrate that administration of GSIs in combination with rapamycin inhibits human T-ALL growth and extends survival in a mouse xenograft model. Given that NOTCH1 may be required to maintain both L-IC and bulk leukemic growth, targeting NOTCH1 may prove to be an efficacious targeted therapy for T-ALL patients with aberrant NOTCH1 activation.
Repository Citation
Cullion KJ. (2009). Mechanisms of NOTCH1 Mediated Leukemogenesis: A Dissertation. GSBS Dissertations and Theses. https://doi.org/10.13028/xy9r-3310. Retrieved from https://escholarship.umassmed.edu/gsbs_diss/537
DOI Link
Rights and Permissions
Copyright is held by the author, with all rights reserved.
Included in
Cancer Biology Commons, Genetic Phenomena Commons, Hemic and Lymphatic Diseases Commons, Immune System Diseases Commons, Neoplasms Commons, Therapeutics Commons


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Is there a way to encrypt any string or file of any length and return a key with a fixed length.
$str = 'Hello World!';
encrypt($str);//returns: "abc123"//a fixed length of characters.
decrypt('abc123');//returns: "Hello World!"//the contents of the original string.
above is in php
Can be any computer language:
Can be any fixed number as long as it's fixed
by fixed i mean always the same: 32 character, 64 characters or X characters.
I have researched a little and it looks like it's hard or imposible. but you never know i thought it might be worthed asking
if you dont ask you don't get :) thnx


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I'm hugely excited to announce that our brand new bridal shoe and evening bag online shop has now launched!
Panache Bridal Shoes provides the latest "on trend" fashions for bridal and evening shoes from world class designers like Pink and Benjamin Adams from Paradox London, gorgeous designs from Badgley Mischka, stunning Clear Bridal collection and the ever popular/retro Irregular Choice.
We are also launching our huge evening and clutch bag collections from a variety of top designers, we're sure you'll find something you'll fall in love with.
Our brand new Facebook and Twitter pages have also launched and we will be updating you all with the latest in bridal wedding shoe fashions to keep you looking incredible on your big day.
The exquisite Pink and Benjamin Adams ranges are gorgeous and compliment any dress style and shape, from bridal gown to evening dress, we think you'll LOVE our new collections.
Pink from Paradox London
Paradox London are all about designer bridal & wedding shoes. They revolutionised the marketplace back in 2002 with a variety of stunning custom wedding shoes which offered a comfortable option for brides walking down the aisle without ever before skimping on style or fashion. They believe that high designer bridal and wedding shoes should be both comfortable and open to all brides to be, whatever their style, location or budget. That is why their highly comfortable designer bridal & wedding shoes can be purchased in over 35 countries worldwide, helping brides to be complete their wedding ensemble, whatever their selection of dress, budget or style.
Pink Paradox and Benjamin Adams
Their first collection arrived with Pink Paradox back 2002. They determined a niche in the market and established themselves as an ardent designer of elegant and stylish yet comfortable wedding shoes. Giving wedding brides to be just what they desired, the Pink Paradox collection became popular, getting almost instant reputation. But this wasn't enough - they got it one step further with this luxurious dyeable silk. At Pink Paradox they focused on assisting you to find the perfect shoes for your dress, which explains why their shoes can be hand-dyed to match any ensemble. At Pink Paradox, the shoes are made to put you first.
The Benjamin Adams brand was created 2 yrs later in 2004 as the leading assortment of their high fashion designs. These stunning shoes, created by Benjamin Adams himself, include a strong and spirited screen of stylish adornments, the best possible silks and the most luxurious foam linings. Whether you're a lover of shimmering crystals or something simple yet impressive, the Benjamin Adams collection offers something just a little different for the most discerning of wedding brides.
Which Designer Shoes MUST I Choose?
This year's collection displays a variety of chic and stylish shoes to match most occasions. Whether you are considering special shoes to walk down that aisle in, shoes to wear as a bridesmaid to your very best friend's wedding or just shoes to wear at a trendy get together, you'll find something in our collection. Both Pink Paradox and Benjamin Adams selections feature stunning amounts of spectacular wedding shoes and luxury custom shoes that are ideal for your future big event.
We hope you love our new Panache Bridal Shoes online shop as much as we do, don't forget to tell your friends and family and those lucky brides-to-be about our collections, follow us on Facebook and Twitter and visit often for great deals and new designers being added.


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Night photography is something I have tried to do more of this past year. It is so much fun to do and it really gives you so many creative opportunities. I enjoy shooting the Milky Way, but even though we live several miles outside of any city, there is still too much light pollution. Star trails are the next best thing, and I have thousands of images on my hard drive to prove it.
This image was created back in late June. The hay had just been baled, so I decided to take advantage of that for some foreground interest. Without any kind of foreground, these usually turn out to be pretty boring images. There are a couple of different methods for creating star trail images. You can take a single, really long exposure. Somewhere in the neighborhood of at least 30 minutes. Or, capture a series of shorter exposures and stack them together. Either way will show the apparent movement of the stars over time, as the earth rotates on its axis.
I choose the use the multiple exposure method for a variety of reasons. With several different exposures, it is possible to throw out one or two that have issues. If you take one really long exposure and something messes it up, then you have to start all over again. One longer exposure will also tend to have more digital noise (grain) due to the sensor heating up.
The creation of this image consisted of capturing about 50 exposures. Each image was exposed for 30 seconds, with only about 2-3 seconds in between each image. They were shot at the relatively wide focal length of 14 mm, at an aperture of f/2.8 to allow in as much light as possible. I kept the ISO at around 1,000, which is about all you need for star trails. A small flashlight was used to light paint the hay bale in one of the images to provide a little more foreground accent.
After shooting, the images were loading into the Lightroom, minor exposure adjustments were made, then exported as JPEGs. The JPEG images were then stacked together in a free software program call StarStax, which works really well. Finally, the resulting star trail image was blended together with the light painted image in Photoshop.
Another thing I should mention is that the camera was pointed in the general direction of the North Star. This makes the circular pattern in the star trails. The extra light trails in the final image are actually fireflies that were buzzing around as I captured the images. I originally thought about removing them, but feel that they add some interest and context to this image. What do you think?


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If someone had told me two years ago that I would be working in retail in 2011, I would've called them a total liar. Now I would have totally had to eat my words. I decided to accept a position at a local outlet store. ( Sorry for the hush-hush; haven't really read up on the etiquette for this job as far as disclosing info online. Hope to be able to share all I can because I LOVE this store and the deals are fantastic!!)Anywho, the job that I took is entry level, low paying, and I love it. I am only part-time but I still enjoy it. It is very different from anything that I've ever done. It's funny to think that I went from being a phlebotomist (diagnostic technician) to being a "store associate". I laugh out loud sometimes when I think about the choices I've made in life. They may not make sense to many, but they make sense to me and that's what counts. Healthcare will always be a part of me, but it just feels good to wear a different hat career-wise. One day I will have that professional career that I've always wanted, but for now, this is okay. It's been a long time since I've been able to say that I actually like my job. Who woulda thought it would be at a store??? Now to figure out how to work and not shop!! I hope I still have a paycheck at the end of the pay period. I already knew that shopping was my weakness and now I work at a store....Ummm...I think I just may have to call shoppers anonymous!!! Thanks for reading...stay tuned for more of me and this thing I call life!!! Peace and blessings!!!
Monday, June 27, 2011
New Job, New Experiences
Sunday, June 26, 2011
Wow! has It really been more than a year????
As strange as it really seems to me, it has been more than a year since I started blogging. How on Earth did I let my blogiversary (May 10th)slide by without notice? It's funny that a year ago blogging seemed like such a big part of my life. What a difference a year makes. life has dealt me quite a few challenges this year and I am still not quite sure if they've made me stronger; wiser for sure, but stronger???? Anywho, it's time to get back to the real reason this blog was started. It was meant to be an outlet for those passions of mine that get buried in this hectic whirlwind called life. My soul aches to pour out the written word but the time it takes is seldom afforded to me. Blogging world you will be my muses along with the rest of world in general as I embark on year 2 of this journey.
My Couponing Experience--My Way
Teens--Raising and learning to let go
New Job---Who woulda thought???
***This is a running list and will include many more, time permitting!!***


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Bella Stone Designs' liability is limited to the repair or replacement of the damaged stone piece(s) only, subject to the availability of matching stone. If the original stone, or a sufficient match is no longer available, and if we determine that a satisfactory repair to the preexisting stone cannot be made, liability is limited to the cash value of the installed piece(s) based on current square foot market price.
This warranty does not include natural characteristics of the stone, such as color variation, fissures, veining, water lines, natural surface marks, or aging. Nor does it cover damage caused by items outside of our control, such as settlement, fire, or acts of nature.
Warranty is valid for stone countertops cared for in accordance with the accompanying care and maintenance guidelines.
For more information on proper care, maintenance, and use of stone, please visit our Material Maintenance page, or visit the Marble Institute of America's Care and Maintenance Guide.


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When you enter a COMMUNE.Yoga (CY) class, workshop, or event, you enter an area where physical activity is likely to occur.
Yoga includes physical movements as well as an opportunity for relaxation, stress re-education and relief of muscular tension. As is the case with any physical activity, the risk of injury, even serious or disabling, is always present and cannot be entirely eliminated. Yoga is not a substitute for medical attention, examination, diagnosis or treatment. Yoga is not recommended and is not safe under certain medical conditions.
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Fishing on the Estate
We have our own loch on the Estate called House Loch. This loch is stocked with Brown Trout and is a pleasant way for our guests to cast a few lines or maybe try fishing for the first time.
We hold a small selection of rods at the hotel and our guests are welcome to pick these up at any time and wander over to the loch for a cast.
Should you wish to fish on one of the larger lochs on the Estate we can arrange for you to do this with Ghillie John McCallum, the prices for this are as follows:
Half Day Trout Fly Fishing
£105 per person
Pick up by Landover Defender from the Hotel.
10.30am – 2pm
Fly Fishing. Full instruction (if required), tackle hire, safety glasses, non-alcoholic refreshments, etc.
Return transport to Cromlix.
Pick up by Landover Defender from the Hotel.
2.30pm – 6pm
Fly Fishing. Full instruction (if required), tackle hire, safety glasses, non-alcoholic refreshments, etc.
Return transport to Cromlix.
Full Day Trout Fly Fishing
(Wild Brown Trout & Rainbow Trout)
£220.50 per person
Pick up by Landover Defender from the Hotel.
9.30am – 1pm
Fly Fishing. Full instruction (if required), tackle hire, safety glasses, non-alcoholic refreshments, etc.
1pm – 2pm
Lunch at the Loch with packed lunch provided by Chez Roux.
2pm – 5pm
Fly Fishing.
Return transport to Cromlix.
Complimentary visual souvenir.
Fishing off the Estate
Cromlix is lucky enough to be surrounded by some great locations to fish for salmon, trout and pike.
River Teith – Salmon - wading and only suitable at certain times of year. – 10 miles
The Teith is renowned for its fishing and for the splendid arched bridge 1⁄2 mile (800 m) southwest of Doune. Confluence of Ardoch with Teith, 3 km downstream from Doune, The Deanston Distillery near Doune uses the Teith to supply water for the manufacture of Deanston Single Malt Whisky.
Frandy reservoir - beginners / kids - fly fishing for rainbow trout (farmed) – 17 miles
The reservoir is well known for its scenic beauty and wide and varied bird life, including Osprey, Buzzard, Hen Harrier, Peregrine Falcon, Merlin and Red Kite.
Lake of Menteith – fly fishing for Pike and Trout – 18 miles
Set in the Trossachs, amidst magnificent scenery where Highland meets Lowland, the 700-acre Lake of Menteith is a well-regarded rainbow and brown trout fishery in Scotland and is reputed to be the best location for fly fishing for rainbow trout and brown trout in Central Scotland.
Loch Leven - experienced fly fishers (wild) – 30 miles
Loch Leven lies in wide basin bounded to the north by the Ochil Hills, with the Lomonds and Bishop Hill to the east and Benarty and the Cleish Hills to the south. Man-made features, such as standing stones, castles, tower houses, as well as 'fermtouns', hamlets and toll houses, are evidence of the long history of settlement in this area.
River Tay – Salmon, river brown trout and grayling – 35 miles
The River Tay begins life as a tiny spring on Ben Lui and changes its name several times before it passes through Loch Tay. By the time it reaches the end of its majestic journey it is almost 2 miles wide and can carry more water than the Thames and the Severn combined.
Fishing Season
Scottish Salmon fishing in Scotland: 1st February until 31st October
The river enjoys a traditional spring run from the opening day followed by an exciting sea trout run between March and July accompanied by a less predictable grilse run. An excellent autumn run continues from late August until the end of the season in October. The Teith has a well-deserved reputation for some large fish and every year fish over 20lbs and even some over 30lbs are landed.
Fishing Hours
Normal fishing hours are from 9.00am until 5.30pm. A 15ft fly rod is suitable for most of the year although smaller rods are appropriate in low water conditions. A house rod is retained throughout the season. A voluntary catch and release policy is operated and anglers are encouraged to return fish in order to aid the recovery of stocks.
Availability of Rods
Up to three rods available throughout the season, for parties of four or more please contact for pricing, although as some bookings are made well in advance especially during the autumn you are advised to book early to avoid disappointment.
|1st Rod
|2nd Rod
|3rd Rod
|Salmon 2
- All rates inclusive of VAT and booking fee, permits, personal qualified Scottish game angling instructor and guide (1 per 3 rods), full top of the range fishing equipment hire, breathable wader & boots hire and photography from their day to keep as a souvenir that will be sent via Dropbox
- Fishing day is from 8am to 5.30pm, transfers included
- Location will depend on individual's experience
- 50% deposit required at the time of booking with full prepayment made 1 month prior
- In event of a cancellation a refund will only be made if the estate can resell the booking
- We advise bookings are made well in advance as Salmon fishing in Scotland is extremely popular and availability becomes limited
- It is advised to tip your Ghillie a minimum of £20
A experienced resident ghillie is booked to provide assistance and advice and to ensure that all new guests increase their chances of success and help identify the pools in differing water conditions. Guests will also greatly benefit from an all-terrain vehicle which makes travelling along the river much easier. The ghillie will also give casting lessons to beginners.
To Book:
Please contact us directly by phone on +441786 822125 or by email at email@example.com