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PDF Price: $30
Back in 1863 Rudolf Virchow, the founder of modern pathology, observed leukocytes nesting in neoplastic tissues ("lymphoreticular infiltrate" in his words). Consequently, he suggested that cancer may arise at sites of chronic irritation. This is how the link between inflammation and cancer was born. Hundred and fifty years later, cancer researches and pathologists have begun to appreciate the significance of the inflammation-cancer nexus. Even though a "lymphoreticular infiltrate" in tumors is often invisible, it is likely that inflammation plays a role in most tumors. However, it remained to determine whether inflammation in cancer is good for the patient and bad for the tumor, or vice versa. In this regard, we have witnessed in recent years a paradigm shift. The dogma prevailing until the turn of the 20th century was that inflammation and immunity play their classical protective role by defeating cancer like pathogens. This view was profoundly outlined in the "cancer immunosurveillance" theory formulated in 1957 by Burnet and Thomas. These two protagonists of the field proposed that lymphocytes act as sentinels in recognizing and eliminating nascent transformed cells that arise frequently in mammalian tissues. However, epidemiological, experimental and clinical evidence failed to support this notion. Numerous studies have demonstrated that immune-deficient humans and mice do not develop cancer at a higher frequency than their normal counterparts, yet, surprisingly, all these negative data only intensified the efforts to reinforce a cancer-debilitated immune system. Immuno-adjuvants, in vivo and ex-vivo immune stimulation by native or modified tumor cells and other attempts to mobilize the immune system in the fight against cancer have commonly failed. But these frustrating efforts have not been in vein. They cultivated novel and heretic trends, beginning by forsaking the cancer immunosurveillance theory and ending with the advancement of initially provocative views, implying that immunity and inflammation may inadvertently serve the tumor rather the host.
What have we learned recently about immunity and inflammation in cancer? We realized that inflammatory cells and cytokines at the tumor microenvironment are more likely to enhance, rather than curb tumor progression and may even induce local immunosuppression. We also understood that cancer susceptibility is often associated with functional polymorphism of pro-inflammatory cytokine genes, and that depriving the tumor of pro-inflammatory cytokines retards its progression in experimental models. A notable example is TNF, once perceived as its acronym stands for: tumor necrosis factor. Today, however, TNF is an outstanding example for a tumor promoting factor. Based on this rising evidence, Mantovani and Balkwill denoted cancer promoting mutations as "the match that lights the fire", whereas inflammation, chemokine and cytokines would be the "fuel that feeds the flames".
Hence, the time is ripe to review the mounting knowledge of cytokines and chemokines in the context of cancer and draw the insights required to harness this knowledge for cancer therapy. This eBook on "The Inflammatory Milieu of Tumors: Cytokines and Chemokines", edited by Adit Ben-Baruch, is an important step in that direction. It provides an updated overview of tumor-infiltrating cells and soluble mediators, while highlighting their role in cancer. It also outlines intervention modes in experimental systems, aiming to turn the microenvironment against the tumor.
We have learned a great deal about the nature, sources and purpose of Virchow's "lymphoreticular infiltrate". The challenge of the future is to develop the means for taming the immune system to extinguish, rather than feed the deadly flames of cancer. Hopefully, readers of this eBook will gain ideas and insights as to how to cope with this challenge.
Yinon Ben-Neirah
The Lautenberg Center for Immunology and Cancer Research
The Hebrew University-Hadassah Medical School, Jerusalem
Tumor development and progression are multi-factorial processes, in which genomic alterations and modifications in gene expression in pre-malignant cells are joined by deleterious microenvironmental factors. The tumor milieu contains stroma cells and leukocytes, soluble factors and matrix components. The intensive interplay that exists between such host factors and the tumor cells plays a major role in dictating the final outcome of the malignant process.
Of the different microenvironmental factors that are present at the tumor milieu, much emphasis was recently given to inflammatory mediators. Inflammatory components may represent early efforts of the host to combat the arising tumor; however, failure to survey the developing tumor and inappropriate control of the inflammatory process may skew the inflammatory mediators into pro-malignancy factors. The inflammatory components support cell growth and invasion, induce mutagenesis, increase angiogenicity, and suppress potential anti-tumor immune functions.
Accordingly, extensive research that has been undertaken in the last several years has led to the current concept, suggesting that the inflammatory milieu in tumors is often overloaded with "enemies within", that may be used by the malignant cells for their own benefit. The inflammatory constituents that prevail in tumors include leukocytes and soluble mediators. Of the different soluble factors, the focus was put on inflammatory cytokines and chemokines.
The aim of the present eBook is to provide in depth description of the roles played by inflammatory mediators in malignancy, and to set the basis for their consideration as therapeutic targets in cancer. The first seven chapters of the eBook describe the tumor microenvironment and its inflammatory components: cells, cytokines and chemokines. The next two chapters describe additional with important cytokines of the tumor microenvironment that are not directly connected to inflammation. The eBook concludes with a chapter describing the potential use of microenvironmental mediators as therapeutic targets in malignancy.
Specifically, the eBook begins by an introductory chapter, presenting the metastatic microenvironment (Chapter 1). This chapter exemplifies the important roles of the microenvironment in metastasis by discussing the large variety of components that contribute to brain metastases (Chapter 1). This chapter is followed by detailed description of the inflammatory microenvironment that prevails in many tumors (Chapter 2). Thus, Chapter 2 describes the cells participating in cancer-related inflammation, and also addresses the value of these cells, and of their products, as potential therapeutic targets in malignancy.
Chapter 3 and Chapter 4 discuss in a detailed manner two inflammatory cytokines that are present at the tumor microenvironment, tumor necrosis factor (TNF) and interleukin 1 (IL-1). Chapter 3 provides a very comprehensive overview of TNF in cancer biology, emphasizing the complex nature of the cytokine and of its doubled-edged effects, at the tumor milieu. Chapter 4 describes IL-1 as a key regulator of the balance between inflammation and immunity at the tumor microenvironment, and highlights the roles played by members of the IL-1 family in many aspects of the cancerous process.
The three next chapters are devoted to inflammatory chemokines in malignancy. In Chapter 5, the focus is put on the ELR-expressing CXC chemokines, describing the major roles of these factors in promoting angiogenesis. Contrasting the activities of the ELR-expressing CXC chemokines, the anti-angiogenic properties of non-ELR CXC chemokines that act through CXCR3, are discussed in Chapter 6. Chapter 6 also illuminates the controversial roles of these chemokines in cancer, manifested by their ability to control leukocyte infiltration to tumor sites and to regulate directly tumor-promoting properties in the tumor cells. This part of the eBook concludes with Chapter 7, in which the multifaceted roles of CC chemokines in malignancy are discussed. The chapter illustrates the pro-malignancy functions of the two chemokines, which are mediated by their roles as typical inducers of leukocyte motility, but also by regulating other malignancy-related functions.
Together, the above-mentioned chapters of the eBook emphasize the divergent functions of inflammatory cells and soluble mediators in malignancy. To provide a more comprehensive view of the tumor microenvironment, these chapters are followed by two chapters addressing additional components of the tumor milieu: the family of homeostatic chemokines (Chapter 8) and transforming growth factor ß (TGFß) (Chapter 9). The chapter on homeostatic chemokines (Chapter 8) describes the characteristics and functions of members of this functional sub-family of chemokines, including in malignancy. Chapter 9 provides a very broad and extensive discussion on the multiple roles of TGFß at the cancer microenvironment, discussing the challenging observations on its tumor-suppressive, alongside with tumor-promoting effects, in cancer.
Following these chapters, demonstrating the high complexity and combined activities of multiple cells and factors at the tumor milieu, Chapter 10 discusses the potential therapeutic implications of the different components that are found in proximity to the developing and metastasizing tumor cells, and describes work-in-progress that is performed in this respect.
Overall, the eBook provides an overview of the different components of the tumor microenvironment, and illustrates the roles played by inflammatory and non-inflammatory components in malignancy. The different chapters of the eBook emphasize the complexity of the cancer milieu, and the fact that often many of its elements are skewed to the pro-malignancy phenotype.
The topics addressed in the eBook are of interest to investigators who study basic aspects of the malignant process, to clinicians who wish to better understand the processes involved in malignancy, and to pharmacological companies that seek novel candidates for therapeutic intervention in cancer.
Adit Ben-Baruch
Department of Cell Research and Immunology
George S. Wise Faculty of Lift Sciences
Tel Aviv University


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E40- Crooked Spies
The guys from Crooked Spies return! I travel to their jam space to talk to them about their upcoming album High Plains and to find out what they have been up to in the months since we spoke last. We talk about all of the effort that went into the making of the album as well as everything from the recording process to the bands favorite moments while making the album. We also touch on topics such as board games, T.V., Pokemon, Yoga and so, so much more. This was a great conversation and I had an absolute blast chatting with these guys again. At the end of the episode you can listen to Raised by Wolves and Seeing Red Both are a sneak peek from Crooked Spies upcoming album High Plains. Available everywhere music is sold Dec. 15th
Be sure to follow Crooked Spies on social media for up to date information on the album as well as up coming shows
Facebook Twitter Instagram Bandcamp www.crookedspies.com
If you would like to support the show please visit our Patreon Page. You will gain access to bonus content that you can only find there. Also please subscribe to our Youtube Channel for access to exclusive content as well

subset: commoncrawl


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Sweet moist chewy macaroons dipped in dark dense chocolate. A Buffalo confection for decades. Box features Buffalo rendering of actual landmarks.
Peanut Butter Shortbread Cookie. They melt in your mouth without sticking to the roof of your mouth. Nickels are legal tender among people with tea and coffee fixations. Box features Buffalo rendering of actual landmarks. 3 grams of sugar and 2 grams of protein per serving.
A tradition for years. Awesome combination of the whole milk, heavy cream, and the finest chocolate. Gluten Free.
Small amount of sugar with the finest egg whites. A light, Fat Free, Cholesterol Free, Dairy Free, and Gluten Free desert option.
A large flat traditional Elephant Ear, flat, flakey, and crispy, with just the right amount of sugar and cinnamon. Each box comes beautifully packaged and ready to eat.
Our legendary Cinnamon Ice Cream. Some zing to the taste. Goes great with apple pie or with our Hot Fudge Sauce.
Call for more information!
(716) 885-7208


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Sadhana, who is credited for introducing the fringe hairstyle in Indian film industry, passed away at a private hospital here, sources said.
Veteran actress Sadhana Shivdasani, known for films like "Mera Saaya", "Wo Kaun Thi" and "Waqt", died here today after a brief illness. She was 74.
Sadhana, who is credited for introducing the fringe hairstyle in Indian film industry, passed away at a private hospital here, sources said.
Her body was taken to her residence in suburban Mumbai where Bollywood personalities, including her former colleague and friend Waheeda Rehman, went to pay their last respects.
Sadhana was admitted to a suburban hospital here last year for a lesion in her mouth and underwent a surgery.
Born in 1941 in a Sindhi family, she was named after her father's favourite actress Sadhona Bose. Her father and actor Hari Shivdasani were brothers. Hari's daughter is actress Babita Kapoor.
Sadhana was the only child and and her mother home-schooled her until she was eight. In 1955 she played a chorus girl in the song "Mur mur ke na dekh mur mur ke" in Raj Kapoor's "Shree 420". She made her full-fldged film debut in the first ever Sindhi film "Abana".
Some of her memorable films include "Love in Simla", "Hum Dono", "Ek Musafir Ek Hasina", "Asli-Naqli", "Mere Mehboob" and "Woh Kaun Thi".
Get live Stock Prices from BSE and NSE and latest NAV, portfolio of Mutual Funds, calculate your tax by Income Tax Calculator, know market's Top Gainers, Top Losers & Best Equity Funds. Like us on Facebook and follow us on Twitter.


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Solvency soon, 'cause we're finally making some money. . ./
A week or so back I went to my mailbox here at home and pulled out a check for $5.00 from the people at CafePress, the online merchandise people who let you sell branded gear for free. If you've ever noticed the Thomistica.net sweatshirts in the right columns ("Got Summa?"), then you've seen these CafePress products. In a fit of creativity of few years back—procrastination?—I put together a fun little product line of things, hoping that now and again someone might buy something, and the money from sales would help to make Thomistica.net self-sustaining. Oh, to have the site be revenue-neutral!
Someone must have taken the bait, because when an item is sold a sliver of the cost goes back to the owner of the "product line," in this case, back to me. So, to whoever actually bought something from the Thomistica.net CafePress mini-site, a hearty thank you for helping to defray the monthly cost of keeping the site going.
Spring's coming, so it may be time to put together some Thomistica.net baseball caps!


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We all know staying hydrated is good for your body, but cannot drinking enough cause you to gain weight?
One study says yes.
It found people who didn't drink enough water were more likely to be overweight.
One reason could be that sometimes our bodies confuse thirst with hunger.
There's no science to back up how much you need to drink every day.
That depends on your weight, activity level, the temperature and other factors.
But generally you should try to drink enough so that you rarely feel thirsty and so that the color of your urine is light.
Water is the best option.
You can also drink decaffeinated tea or coffee or carbonated water.
And eating fruits and vegetables during the day will also help you stay hydrated.
Study: Not drinking enough water linked to weight gain
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Industrial repeaters are professional mobile signal enhancement equipment, used to fill in gaps and optimize performance of mobile operators' base stations. The systems have high quality noise protection and comply with CE, RoHS, ETSI and 3GPP 3GPP2 standards.
Huaptec offers two kinds of industrial mobile repeaters – analog and digital. Both of them are narrow band and are adjusted strictly to the bandwidth of a mobile provider. Analog industrial repeaters provide amplification of fixed sub bands, and in digital models the bandwidth is movable by the software.
Look through the catalogue below to choose the system best suitable for your needs.


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The following attachment shows a list of the extra material that the GamebaseST team have gathered for games in the database. Please check the relevant attachment to see if the project does not already have it before submitting material.
Note, that I am currently working through the extras to append language information to the end of the filename. Also the boxscans need extra information if they are from a budget releases, for example Pipe Mania (Tenstar) - front. These couple of shortcoming will be fixed in the next couple of weeks!
Please note, these lists will be updated on a weekly basis. Also, sorry about the crudeness of the directory listings.
List dated 21/02/06:


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by Pat Hammond on Saturday, April 15, 2017
Has anyone else noticed that the only people who think using social media to market your business is easy are the people who don't actually have a business?
Don't get me wrong, Facebook, Instagram, and Pinterest are great options for a budget conscious business owner, but they're not easy.
They require careful planning, a commitment to regular posts, and a willingness to engage not only with the people who follow you but in whatever group or conversation you find your target market. And this all has to be done without sounding like you're spouting a canned sales pitch.
As if that wasn't enough, you have to block off time away from running your business for each and every social media platform you use. It's not hard if you have the time and tools, but when you're a small business owner there is never enough time.
This month's Live from the Hive guests are Stephanie Edwards from Social Wize, LLC and Graham Gifford from the NH Telephone Museum.
Stephanie will be sharing insider tips and tricks on how to tackle your social media marketing, and Graham will be talking about glow worms and how to overcome perfectionism. And yes, you read that right, I said glow worms. (Hint: They play an important role in the latest Telephone Museum special exhibit.)
Stephanie Edwards
Web: http://socialwizellc.com
Email: firstname.lastname@example.com
Graham Gifford
NH Telephone Museum http://www.nhtelephonemuseum.org/
Present Over Perfect: Leaving Behind Frantic for a Simpler, More Soulful Way of Living, Shauna Niequist
How to Mentor a Perfectionist, W. Brad Johnson and David G. Smith, Harvard Business Journal


text: Advertisement Advertisement Entertainment 10 Ways We Relate to Louise Belcher from 'Bob's Burgers' By Chase Hill May 17, 2016 | 11:26 AM She might be the tiniest member of the Belcher family, but that doesn't stop Louise Belcher from having one of the biggest (and funniest) personalities. Voiced by the absolutely humorous and beautiful Kristen Schaal, Louise has become one of the most recognizable cartoon kids in television history. Here's 10 reasons why we relate to the hysterical Louise Belcher. Next Gallery PHOTOS Hollywood cast reunions Hollywood cast reunions PHOTOS Celebrity kids who look just like their famous relatives Celebrity kids who look just like their famous parents Advertisement Featured Photos Featured Most destructive winter storms of the decade Winter storms famously pummel the northern U.S. each year, but every state has experienced its share of severe winter weather. Freezing rainstorms have glazed Texas cities in ice, snowdrifts have buried cars in New Mexico, and thundersnow storms have knocked out power nationwide. For regions acclimated to harsh winters and those that aren't, cold weather storms can disrupt daily life and cause extensive damage. This is because it's challenging to forecast snow. The temperature line between snow and rain is razor-thin, and the different types of snow to contend with—from light and powdery to wet and heavy—complicate predictions and preparations. Even when storms are accurately predicted, only so much can be done to prepare for the impending weight of snow on roofs and power lines. Add high winds and low visibility, and snowstorms become full-blown blizzards, capable of shutting down major roads and collapsing buildings. Blizzards are just as treacherous as ice storms. Freezing rain falls disguised as normal rain—but when a layer of cold air above the ground super-cools water droplets, rain forms ice over the surface and can quickly accumulate and add weight over the roads, roofs, trees, and power lines they fall on. Such storms can create widespread power outages that take weeks to restore. To establish the most destructive winter storms of the decade, Stacker consulted the National Oceanic and Atmospheric Administration's Storm Events database from 2010 up to September 2019. The storms were ranked by the highest dollar value of property damage across the states affected. Stacker's list includes ice storms, blizzards, frosts, freezes, heavy snow, and sleet. Although the database is comprehensive, damage reports often come from local sources and may, therefore, be incomplete. Read on to learn where and how winter storms caused the most damage in the past decade. You may also like: 15 wild weather phenomenaVisit thestacker.com for similar lists and stories. By Jackie Rocheleau Nov 19, 2019 Where to get a great vegan meal in all 50 states 24 merry and bright things Christmas lovers are guilty of 10 essential Black Friday shopping tips from the pros From cards to crafts, 14 ways to keep kids busy during delayed flights 20 things you're doing at the airport that you might not know are rude How to prepare for, and deal with, getting stranded in your car during the winter Which Thanksgiving foods you can and cannot take on your flight Advertisement


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Bob Baker's The Buzz Factor
Music marketing tips and self-promotion ideas for independent songwriters, musicians and bands.
Bob Baker's Indie Music Promotion Blog
Music marketing ideas for DIY artists, managers, promoters and music biz pros
December 08, 2008
Look Who's Talking About Me Now
How to be a Smokin' Hot Piece of Brain Candy
7 Reasons to Go Indie!
Advertising Tips for Using MySpace, Part 3
Voting, viral marketing and Music 2.0?
I'm back!
The Bob Baker Experiment
What's Wrong with 'American Idol'?
Firmly resolving ...
The Slow Build Approach to Book Marketing
How to Finish and Publish a Book
Why Book Promotion Is Like Dating
Bob Baker: conseils
I appreciate the link love!
Check out Guerrilla Music Marketing Handbook, the classic guide to indie music promotion. Now revised and updated, with four new chapters on Internet and Web 2.0 music marketing. Get more tips like these when you subscribe to my free Buzz Factor ezine — the longest running music career tips email newsletter on the planet. Since 1995. Learn more about the free subscription here.
Your email address will not be shared. Unsubscribe at any time.
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posted by Bob Baker @ 3:42 PM 1 comments
1 Comments:
- At Dec 14, 2008, 4:26:00 AM, Alain Jamot said...
Thanks for the link!
You know, even in Paris, we read the famous Bob Baker and his great advices !
FREE Music Tips Ezine
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Bob Baker is an author, speaker, teacher, indie musician and former music magazine editor dedicated to showing musicians of all kinds how to get exposure, connect with fans, sell more music, and increase their incomes.
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Title: Professor Emeritus
Office: Rm 20 ChB
Labs: 062, 004, 009, 010, 012 & 013 Chb & 13, 26 PAB
Phone (Office): 519-661-4180
E-mail: email@example.com
Nanoscale Surface, Materials and Interface Science
Ph.D. (University of Nottingham, UK)
Research in our group Interface Science Western (ISW) is very broad and a more detailed description can be found on the ISW web page listed below.
Nanoscale Phenomena: A variety of nanoscale phenomena are under investigation using a range of probes such as AFM, IFM, STM, NSOM and confocal microscopies. These include: molecular basis of organometallic CVD; in-situ polymer film formation on semiconductor surfaces; creation of patterned nanoscale arrays on surfaces; nanoscale mechanical properties of materials and interfaces; friction, lubrication and wear (tribology); nanoscale mechanical properties of biological cells and biological cell signal transduction. Materials include polymers, cells, alloys, semiconductors, oxides. The goal is to understand the influence of interfaces and nanoscale structure on materials design and properties.
Surface Chemistry and Dynamics: The reactivity of surfaces is studied by a range of methods and new methods are continually being developed. These include microsecond time resolved IR of surface (UHV, electrochemical...) processes. Internal energy states of catalytic reaction products are being investigated.
A major theme of the group is the interaction of water and oxygen with surfaces of materials such as metals, alloys, semiconductors, polymers. Modification of the properties of polymer surfaces for biomaterials applications. An extensive program is underway looking at interfaces in organic light emitting diodes (OLED's).
Industrial and Other Interactions: The group works closely with industry on long-term projects relevant to industrial interests. Currently work is underway with Xerox, General Motors, Alcan, Mitsubishi. The group is associated with various Neworks: Materials and Manufacturing Ontario, Canadian Institute for Photonic Innovations and has recently received significant CFI funding.


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The voice over internet protocol is the device which transmits the voice messages from one person to another through the internet but now, there are a lot of benefits of voice over internet protocol which helps you in getting a competitive edge over all other companies. The call route system on your computer which is easy to use and a unified system all over the office or even many offices. The voice over internet protocol is the system which changes your ISDN connection into single IP and can offer up to 700 channels with good speed, reliability, and security. These benefits are increasing the efficiency and the productivity of the business that is why many of the businesses are switching to voice over internet protocol from the old tradition telephony services or many other services but there are some of the reasons that why people get attracted to this service and like it so these reasons are given below:
Voicemail, caller ID, call forwarding, caller ID blocking, these are the free features which generally have in VoIP service but as compared it with any standard telecommunication company you will see that they will charge extra for adding these features on. If you do want to add some more features than you can get things like: Find Me Follow Me (rings your home number first, then your work, do not disturb and etc.
Phone cost
The biggest benefit of wholesale sip termination is it reduces the cost of phone bills. Even you can use internet with full speed and unlimited. You can cut down the landline phone calls and long distance phone calls bills. Many people want a good speed internet but a voice over the internet gives good speed, VoIP calls which reduce the cost of maintenance, equipment, and lines. It is always free in this offer. Today if we check that a telephonic service from a standard telecommunication has cost almost 23- 38 dollar per month but if you see that voice over internet protocol average cost range is about 8-15 dollar per month there is a huge difference if you see both services. This can help you in saving more money.
Call quality
This is usually the biggest thing which people say and switch to voice over internet protocol provider from the standard phone services. This is usually the biggest argument while they comparing phone service to voice over internet protocol but this is just a rumor because as now even many branches of government are beginning to use voice over internet protocol.
The best thing in voice over internet protocol is that there is no hard and fast rule or even not a major installation issue when you implemented a new handset. So when you want to put a connection in ISDN you should have to have an engineer and physical line installed. This thing will reduce the amount of commotion in the office work while even the working is happening. This thing also helps you in growing and expanding your business


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Software Download Links
Google Drive
Get access to files anywhere through secure cloud storage and file backup for your photos, videos, files and more with Google Drive.
Slack is where collaboration flows. It's where the people you need, the information you share, and the tools you use come together to get things done.
Plan for anything. Organize and share your to-do, work, grocery, movies and household lists. No matter what you're planning, how big or small the task may be, Wunderlist makes it super easy to get stuff done.


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- Mr Manoj
Sangli - Mumbai, One Way
14th Nov 2019
- Michael Ekka
Chhatrapati Shivaji International Airport (bom), Mumbai - Pune, One Way
14th Nov 2019
- Govind Kumawat
Chhatrapati Shivaji International Airport (bom), Mumbai - Ahmedabad, One Way
13th Nov 2019
- Angad Bhatia
Panvel - Panvel - Pune, Round
12th Nov 2019
- Shribhushan Patil
Chhatrapati Shivaji International Airport (bom), Mumbai - Pimpri Chinchwad, One Way
11th Nov 2019
- Anup Kumar Dash
Panvel - Alibag, One Way
11th Nov 2019
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Gozo is continuously focused on being and staying as India's best taxi service for inter-city or outstation car hire with a driver.
Gozo cabs is the best cab service for car hire from Belgaum to Mahabaleshwar. Gozo is generally the cheapest in most regions as we keep our margins low and we keep our quality high by ensure that our cabs and providers are inspected regularly. At the time of onboarding, the taxi operators are whetted for proper licenses and their ability to meet our quality bar. We also provide ongoing training to our drivers. But most importantly Gozo strives to be the best with our support and customer service. Gozo has great reviews on Google & TripAdvisor.
Gozo was started with the focus of simplifying car hire for outstation trips and we specialize in one way cabs, round trip journeys and even multi city trips. Car rentals in Belgaum or Car rentals in Mahabaleshwar are also provided. We offer daily car rentals and also airport transfers in most cities across India.


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View here: Notes from Curating Forum, 18 November, 2017
Saturday 18 November, 2017
Curating: a Concept in Transition is a forum designed to explore the new possibilities that emerge when artists, researchers, curators, educators and their publics join forces to examine and re-specify what a gallery can be, what an artist is and how the borders between curating and creating might be tested and stretched.
Once upon a time curating was a clearly defined profession based on scholarship, connoisseurship and, to a large extent class. But as contemporary art and society changed so has the position and role of the curator. With the rise of artist curators (e.g. Grayson Perry and Damien Hirst) curating has become a concept in transition. The lines between creating and curatinghave become blurred. Furthermore the re-emergence of artist run spaces with a variety of competing social agendas suggest the possibility of new ways of challenging the established hierarchies of power and knowledge within the art world.
The Gallery at Phoenix Brighton is a space that has deliberately chosen not to have an artistic director. We are moving towards a place where the gallery functions as a piece of un-common ground designed to estrange practitioners and our public from their usual assumptions and rituals. In this spirit we are convening this forum as the first in a series of events, exhibitions and debates with those in our immediate region and beyond.
We are looking to connect to what we see as the emergence of a broadly based network of social and cultural movements that has been called the 'social turn'. The event uses these initial ideas as a lens with which to explore various models of collaboration between artists, curators, researchers and publics and to reflect on how these experiments might impact upon the cultural and physical context of the contemporary gallery space and how we might articulate these thoughts in a program of exhibitions, events and workshops.
Topics include:
- 'DIY' (or tactical) curating
- Art as public research/gallery as laboratory
- Conversations across difference
- Re-framing globalisation – How local cultures feel the pressure of global forces
The forum is presented by Phoenix Brighton and takes place alongside an evolving participative exhibition in the gallery ('Maps & Lives', 11 November – 3 December) curated by Lara Perry, Louise Purbrick and Claire Wintle.
Lead Contributors:
David Garcia (moderator) is an artist, teacher and organizer who has pioneered new forms of critical engagement with art and media based on occupying of the cracks which began to appear in the edifice of the broadcast media in the 1990s.
Lucy Day (moderator) is a feminist freelance contemporary art curator with a particular interest in the relationship between heritage and contemporary art practices.
Felicity Allen's expanded practice weaves in and out of art's institutions, between artistic, curatorial, educational and critical work.
Elke Krasny is a curator, cultural theorist, urban researcher, writer and professor at the Academy of Fine Arts in Vienna.
Lara Perry is an art historian with specialist research expertise in portraiture, gender and British art.
Rockets Artists is a group of artists with learning disabilities who make visual artwork, create performance and curate exhibitions from their studio base at Phoenix Brighton.


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Disc herniation and lateral spinal stenosis are two conditions that can lead to severe back pain for many people. Sometimes the pain is temporary and is easily resolved with conservative treatments, such as rest, anti-inflammatory medications, steroidal injections, and rehabilitation. However, for others, the pain can be excruciating and long lasting, regardless of what is done to correct the problem.
Advances in surgical techniques and medical instrument technology have brought on vast improvements in the treatment of these spinal conditions. This guide describes two new and exciting procedures available at the Bumrungrad Spine Institute. They are the least invasive spine surgeries to date to remove a portion of a herniated lumbar disc or decompress a constricted nerve root in lateral stenosis.
You can see images of the surgery in the following video:
Spine Institute
Bumrungrad International Clinic (BIC) Building , 20th floor
Bumrungrad International Hospital, Bangkok, Thailand
Online Appointment: Make appointment here
Learn more: Ask us a question


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I love doing TV segments any time of year - and especially during the holidays!
TV studios are decked out for the season, I get to bling out the table with holiday decorations, and everyone is in a festive mood. And sometimes - as in the case of this segment at "San Antonio Living" last week - they give me a little soundtrack of Christmas music as a background during the segment.
Doesn't that make you feel just a tiny bit more festive? Check out the the full segment here!


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RICHMOND, Va. – Coming off yet another 20 win season and a trip to the NCAA Tournament, the Virginia Commonwealth wanted to start the 2011 campaign off on the right track when it opened the annual 4-1 Invitational, hosted by the Rams at the Thalhimer Tennis Center.
The Black & Gold did just that, gutting out a 3-2 victory over a feisty Georgetown team and following it up with a 5-0 rout of Howard University.
"It was a good first day for our girls," Head Coach Paul Kostin said. "We got a gut check by a good Georgetown team that really fought hard and challenged us in a match that could have gone either way. I'm happy with the way we were able to stick with it and get two wins, it definitely beats the alternative."
The freshmen duo of Daria Yakavleva and Olga Terteac started the day off strong for VCU with a 6-4, 6-0 doubles win over the Hoyas' Alex Sebia and Madeline Jaeger.
Georgetown would bounce back with their top player, Stephanie Wetmore, grinding out a 6-4, 4-6, 6-4 win over Ana Bara and Tina Tehranl taking a 7-6 (3), 3-6, 6-4 decision of Isabel Fernandez at the fourth position.
However, the middle of the Rams lineup would secure the 3-2 win as sophomore Josefin Hjertquist battled to a 3-6, 6-3, 6-4 win over Lauren Greco and Alex Bara swept to a 6-1, 6-2 win over Victoria Sekley.
"Of course you want ever match to a be a 5-0 win, but that's not what happened," Kostin said. "We still have a lot of work to do, but a win is a win."
The Rams would focus in for their second match with five straight set victories over the Bison. Hjertquist and Ana Bara teamed up in doubles for a 6-1, 6-1 win over Howard's Alyssa Works and Ashley Moore.
Senior Kateryna Yergina kept VCU going with a 6-0, 6-2 over Michelle Brown at the top position. In the first singles matches of their careers Yakavleva and Terteac both swept their opposition.
Sophomore Manuela Pieztuch moved to 7-0 in her Black & Gold career with a 6-0, 6-1 victory over Brooke Hawthorne in the fourth spot.
The Rams return to action with one match during Saturday's 4-1 action with a 10 a.m. showdown with the Penn Quakers.
VCU 3, Georgetown 2
Yakavleva/Terteac d. Alex Sebia/Madeline Jaeger, 6-4, 6-0
Stephanie Wetmore (GU) d. Ana Bara, 6-4, 4-6, 6-4
Hjertquist d. Lauren Greco, 3-6, 6-3, 6-4
Alex Bara d. Victoria Sekley, 6-1, 6-2
Tina Tehrni d. Fernandez, 7-6 (3), 3-6, 6-4
VCU 5, Howard 0
Hjertquist/Ana Bara d. Alyssa Works/Ashley Moore, 6-1, 6-1
Yergina d. Michelle Brown, 6-0, 6-2
Terteac d. Brittney Morgan, 6-2, 6-0
Yakavleva d. Katelyn Stokes, 6-4, 6-4
Pieztuch d. Brooke Hawthorne, 6-0, 6-1


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01 987087
Fakhry Bey
The brand Bleu comme gris Paris was created with the aim to bring back the prestige of school uniforms. Established in 2008, the brand is now a reference for parents as well as schools that wish to propose uniforms to their students. Today, the school uniform is no longer a sign of strictness but rather of differentiation. This is why all the Bleu comme gris' collections are made with attention to detail and the desire to create aprons that are different, sober and fashionable. Following the success of BCG School uniforms, Vanessa Marrapodi, the artistic director of Bleu comme gris, decided in 2010 to expand the brand's range and offer every day, casual smart clothing. Timeless, classic fashion known for its subtle colors becomes up-to-date thanks to the contemporary touches added by the brand. The collections become rapidly a must have for every trendy teenager, girl or boy. In September 2014, Bleu comme gris decided to expand its offering and to associate with Maloup, a brand famous for stylish and comfortable pyjamas and for its ready-to-wear children collection. Together, the brands created a new range of pyjamas and loungewear – « Bleu comme gris by Maloup » that is incorporated in Bleu comme gris' collections. Bleu comme gris offers in all its stores and all year round, trendy clothing for children 0 to14 years old.


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Vascular Access
The vast majority of children at The Hospital for Sick Children require intravenous or vascular access devices that are able to deliver fluids and medications as part of the treatment plan for their health condition or for diagnostic tests. Indeed many children require devices for longer term treatment lasting a few weeks to years. The high degree of patient acuity, coupled with the fact that SickKids patients are children of all ages, can make even the seemingly simplest of peripheral intravenous line (PIV) insertions a challenge.
Recognizing the need for the re-emergence of a specialty team dedicated to initiating PIV and managing other types of vascular access devices (PICCS, ports, CVL), the Vascular Access Service was redeveloped and found a new home within the Diagnostic Imaging Department in June 2007. Starting with two full-time (Francine Faubert, Susan Kirkos) and three part-time staff (Roze Kovalakovska, Susanne Bush, Ray Lam), the Vascular Access Team focused on hiring staff and building on their expertise in PIV insertion. By December 2008, the team was completed with an additional nine RNs for a total of 7.1 FTE. During this time, the Vascular Access Resource Nurses (Mari Acebes-Carcao, Alona Abramovich) were integrated in the Vascular Access Service while still maintaining a very close working relationship with IGT and reporting to the manager for Vascular Access Service. We have also increased the number of nurses in the Vascular Access Resource role from 1.0 to 1.5 full-time equivalents.
Another priority for the Vascular Access Service has been to increase the overall capacity at SickKids for performing PIV insertions by developing core groups of in-patient nursing staff and medical residents. To facilitate this process and to establish a consistent, structure approach that adheres to safe occupation health and safety practices—to keep our staff safe—and adheres to good infection control practices and practice standards—to keep our children safe—a Clinical Instructor role was initiated in September 2008. The role was open to all Vascular Access Team members and Kim Newcombe was the first Vascular Access Team member to hold this one-year term position. Her pursuit of specialty certification with Infusion Nurses Society and the Canadian Vascular Access Association has helped her expand a comprehensive training program for paediatric PIV insertion that provides intensive one-on-one support for people new to the skill along with on-going follow-up.
Future Initiatives
As we continue to build the Vascular Access Service, we will move toward expanding the PIV insertion education program to first-year medical residents, more nurses and medical radiation technologists. We will build on the role of the Vascular Access Team by developing each team member's knowledge and expertise in managing complications from central vascular access devices (CVAD), work on quality improvement projects aimed at reducing the number of CVADs requiring repair, and explore technologies that will assist in visualizing peripheral veins for those difficult PIV insertions in children. We will also improve our ability to deliver excellent procedural pain management strategies for PIV insertions by collaborating with the various in-patient units and supporting organization-wide initiatives. Other key projects will be the renewal of the policy and procedures associated with vascular access and the development of clinical practice guidelines to support health-care teams in selecting the most appropriate vascular access device for their patients. The Vascular Access Service is looking foward to another full and exciting year.
Advanced Nursing Practice Educator
Darlene Murray
Vascular Access Resource Nurses
Mari Acebes-Carcao, Deborah Kern, Alona Abramovich
Vascular Access Team
Paul Dupuy, Francine Faubert, Susan Kirkos, Shelly Philip Laforest, Alla Raitsin, Josephine Lazaro-Caetano, Nicole Anstey, Roze Kovalakovska, Susanne Bush, Sheri Backman, Ray Lam, Eileen McGuchan, Pam Sattz


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Scope of the internship
In order to improve the efficiency and effectiveness of our operations and further improve customer satisfaction and engagement, we require additional support for our country managers.
The principal objectives to be achieved are as follows:
1. Coordinating with country managers on the design of new in-game activities as well as activities on various social platforms;
2. Writing creative announcements to encourage customers to partake in various events;
3. Daily testing of the games to check for game bugs and improve product understanding;
4. Business intelligence: gathering internal feedback on activities and customer preferences;
5. Supporting the daily operational work, e.g. handling customers' requests and questions and determining appropriate solutions.
l Hours per week: 40 - 45
l Salary: € 550,- gross per month excluding possible compensation of equipment
l Additional benefits: paid holiday leave; flexible working hours; recreation area; company activities, e.g. company dinners and sports activities
Working at TFJoy means working in a dynamic, flexible, proactive and multicultural environment. To encourage communication, cooperation and critical discussions within our company we regularly hold team events which lead to closer ties among colleagues, on a personal as well as a professional level.
1. We are looking for a candidate who is able to work within a dynamic organization; in which many new abbreviations and business talk will come along. We believe that an independent, proactive and curious, self-starting candidate would fit the company.
2. We are looking for a Business School student with management/media/communication education and an aptitude for IT.
3. The student should be a Mandarin Chinese native speaker. In addition, good proficiency in English speaking, reading and writing is preferred.
4. An interest in playing games is appreciated, especially mobile games.
5. Well-organised and detailed person with good time-management and good communication skills. The ability to handle multiple projects and multi-customer environments simultaneously as well as adequate problem-solving capabilities are also required.
l Required language skills: Mandarin Chinese and English
TFJoy, short for Tap For Joy, is a leading mobile game publisher for game companies that want to expand internationally. Our focus is on bringing high-quality games to various markets, providing the game in the local language as well as offering high-quality local support.
With over 10 years of experience in the mobile game industry, 3 veterans set out to establish a mobile game company that would do more than simply publish games. They envisioned a game company that would offer continued support to players across the world, in their own language and for as long as they want the game to be supported. With this in mind TFJoy was founded in Hong Kong in 2013. Since then TFJoy has released various games in different markets and languages, with the number of markets we operate in increasing at a rapid pace. We pride ourselves on our market understanding and knowledge of country-specific distribution and marketing channels.
We genuinely believe that mobile games can bring joy to the daily lives of people and provide our products and services to as a big a population as we can with this in mind.
Our primary customers are hard-core gamers or young students. Our game purchasing team identifies and buys games around the world. These games are subsequently localised and tested in specific markets; we are looking for native people to assist in the daily operations across our various markets.
l Industry: Information / Communication
l Organisation size: 11 - 50
l Company website: http://www.tfjoy.com
If you are interested in joining us, please send your cover letter and CV to us.


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They'll play Coachella, Las Vegas and New York City
The Verve have announced a handful of dates in the US, kicking off at Coachella on April 25.
The band will then head for Las Vegas to perform at the Palms before crossing the country to the east coast for two shows at the WaMu Theater at Madison Square Garden in New York City.
Tickets for the New York shows go on sale this Saturday March 1 at 11am.
The band recently played a successful string of sold-out comeback shows in the UK.
The dates are:
Indio, CA Coachella (April 25)
Las Vegas, NV The Pearl Concert Theater at the Palms (26)
New York, NY WaMu Theater at MSG (28, 29)
–By our New York staff.


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Startups are something the UK isn't short of, in fact according to Startup Britain's Tracker, 24,483 startups launched just this month alone and in the last year a record 3 million…
However despite the UK's success in starting businesses there is not enough of these scaling into larger companies. So while it's essential for us to continue to invest in high growth and innovative start-ups, focusing support on scaling businesses is critical to successful UK economic growth.
So, what's a scaleup?
A Scaleup business is defined as a business who has an average annual increase in revenue of at least 20% in the last three years. *According to the OECD.
The Scaleup North East programme aims to create more than 1,300 new jobs and boost the number of scaleup businesses in the region by 50% in just 3 years.
However, we are keen to not only support the region's existing 400 scaling businesses but importantly work with the thousands of businesses on the cusp of scaling, that have real drive, ambition to grow and the opportunity to positively impact the region's economy.
So why is it so much easier to start up than scaleup?
There are many barriers to scaling up, investing in infrastructure to enable high growth, developing and managing culture of growth, building the right team and helping managers to become leaders, to name just a few.
The Scaleup North East programme is welcoming eligible companies onto the programme…
Define eligible?
- Be based in the North East Local Enterprise Partnership area (Northumberland, Tyne and Wear, County Durham)
- Be a registered company and have been trading for more than three years
- Have a minimum of five and less than 250 employees (FTEs)
- Have an annual turnover of less than €50 million
- Operate in an eligible ERDF sector
But its more than that…
Growth mindset
Business owners often believe that the success of their business depends on the strength of their product of service. But there is one variable many overlook…themselves. Ambition is the driving force behind any businesses transformation. You must want to change, to create realistic growth targets and develop concrete action plans of how growth will be achieved. Scaleup North East is designed to work with companies that have this crucial factor and help support the ambition and nurture it through a unique partnership approach.
The Scaleup Partnership
Any successful business needs a sounding board, someone who can challenge you, work with you and keep you on your toes and that's where our Scaleup Partners come in…
You will be matched with one of our highly experienced Scaleup Partners who will work with you to understand your objectives, agree your key challenges, help you develop a clear Action Plan and above all else keep you focused on the end goal – scaling.
If you think your business is perfect for the Scaleup North East programme then give our team a call on 0191 516 4400.3
Scaleup Provider Coordinate A Complete Brand Transformation
Scaleup Provider, Absolute has worked on a complete brand transformation with a well-known North East solid wood rustic furniture ...
07th November 2019
Getting Behind The Businesses Who Can Drive Our Economic Future!
Scaleup businesses represent less than 1 per cent of the North East's business population, yet deliver more than 33 per cent...
01st November 2019


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Actor Rowan Atkinson says playing the fun−filled character in comedy series "Mr.Bean" does not suit him anymore and he might do less of it.
The 50−year−old actor admits that although playing the lead role in the show has been very successful, but the mute character has become tiring for him.
"The stuff that has been most commercially successful for me − basically quite physical, quite childish − I increasingly feel I'm going to do a lot less of," Daily Telegraph quoted him as saying.
"Apart from the fact that your physical ability starts to decline, I also think someone in their 50s being childlike becomes a little sad. You've got to be careful," he added.
"Mr.Bean" first aired on television in 1990 and was on air for five years and has received a lot success.


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Artifact Details
TitleComputers for people - part 1
Catalog Number102738507
|Felsenstein, Lee, Speaker
|Fox, Annie, Speaker
|Fox, David, Speaker
|Nilles, Jack S., Speaker
|Severa, Tony, Speaker
PublisherAdams Convention Reporting
Place of PublicationSan Francisco, CA
Identifying Numbers
|Other number
FormatStandard audio cassette
DescriptionRecording of the session titled "Computers for people" held at the Fourth West Coast Computer Faire in San Francisco. The following papers were presented:
"Learning to live with computers," presented by Annie Fox and David Fox.
"The personal computer as a social tool," presented by Tony Severa.
"Telecommuting via the personal computer," presented by Jack M. Nilles.
"The golemic approach," presented by Lee Felsenstein.
Series TitleFourth West Coast Computer Faire
CreditGift of Jim Warren
Lot NumberX2595.2004
Related Records
|Digital communication for the public - part 1
|Digital communication for the public - part 2


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Tennstopet – a true classic on the Stockholm restaurant scene
Traditional Stockholm pub and restaurant Tennstopet opened 150 years ago – and it's known for its classic cuisine and well-preserved décor. Classics such as brandy flambéed pepper steak with pepper sauce sit alongside Swedish fare like Wallenbergare, Beef Rydberg, lutefisk, home salted salmon, and cheesecake.
Tennstopet also has a 'food calendar' – a menu that follows the hunting season, which means you'll find, among other things, wild boar, spring fowl, hare, crayfish and fermented herring.
While it's good to book ahead you can usually grab a table just by stopping by, particularly during the summertime when there are plenty of tables outside. The restaurant is open every day other than Christmas Eve, Christmas Day, Midsummer's Eve and Midsummer's Day.
Welcome to Tennstopet!
+46 (0)8 32 25 18
Price range: High
Cuisine: Traditional Swedish
Opening hours
Monday 11:30 am – 1 am
Tuesday 11:30 am – 1 am
Wednesday 11:30 am – 1 am
Thursday 11:30 am – 1 am
Friday 11:30 am – 1 am
Saturday 1 pm – 1 am
Sunday 1 pm – 1 am
Social Follow
|Dalagatan 50, 113 24 Stockholm, Sverige
Dalagatan 50
Related Places


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"Does the unit have power?"
Check to ensure the device is actually receiving power by turning the TV ON. In most cases a power indicator light will be illuminated on the front of the TV, if the option has not been disabled by the customer.
Press the menu button once the television has been powered on to ensure the TV is functioning properly. Use the menu button on the actual TV itself to test.
"Let's check some of the other inputs to see if we get a picture"
Is a DVD/BD Player, Game System, VCR, etc. connected to the television?
"Is an HDMI cable being used for any of the connections?"
If HDMI is being used and the SIMPLINK option is turned ON, this could cause a 'no signal' message to appear when trying to switch inputs manually on the TV.
Turn the SIMPLINK option off by pressing the SIMPLINK button on the bottom of the remote control or accessing the option in the setup menu of the TV.
Does the picture appear?
"Is a High Definition Cable or Satellite box being used?"
If yes:
If no:
Does the picture appear?
"Do you subscribe to Cable or do you receive channels from an antenna?"
2nd Call:
Complete All TS Steps
Service Options: LG TV
In-Warranty E-Dispatch Process
Is this the first call for this problem?
If Yes: Continue with 1st Call Troubleshooting steps.
Customer Education:
"If the unit shows 'no signal' or a black screen, this is usually due to the device being on the wrong input"
Lets perform some simple troubleshooting steps to see if this issue can be resolved over the phone.
How-to & Tips
Find help information for your LG product


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We use cookies to ensure that you are getting the best experience on our site.
We never store personal data in cookies. If you'd like to you can read more about our cookie policy and privacy policy.
Rob Whiteman, Chief Executive of the Chartered Institute of Public Finance and Accountancy (CIPFA), comments on the demands CIPFA has made, alongside businesses and local governments organisations, to the government on business rate reform:
'CIPFA strongly supports reform that would enable local economies to grow and fully recognises that local government may need to be more flexible with businesses to encourage this. However, we are conscious that a move to CPI must not further reduce funding for local authorities whose budgets are already stretched.
'The CBI have calculated that a move to CPI from RPI could save firms up to £1.5bn annually. This should not be an excuse to undercut funding to local government by this amount. Any such reform to the way business rate increases are calculated must ensure funding for councils remains fiscally neutral.'
CIPFA Press office
E: email@example.com
CIPFA, the Chartered Institute of Public Finance and Accountancy, is the professional body for people in public finance. Our 14,000 members work throughout the public services, in national audit agencies, in major accountancy firms, and in other bodies where public money needs to be effectively and efficiently managed. As the world's only professional accountancy body to specialise in public services, we champion high performance in public services, translating our experience and insight into clear advice and practical services. Globally, CIPFA shows the way in public finance by standing up for sound public financial management and good governance. We work with donors, partner governments, accountancy bodies and the public sector around the world to advance public finance and support better public services.


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Ever felt like your board level MOSFETs were too large?
Texas Instruments now has an answer!
I spent some time mocking up a case for the lights. I'm not totally happy with the side panels yet (more on that later), but a quick walk through the process:
This design has been on my back-burner for quite awhile, but its time to write it up and continue pressing on.
I really like reef aquariums. I currently have a (modest) 90 gallon system, which has livestock dating back to when I started keeping salt-water systems in college (circa 2004). How I managed to actually afford keeping a salt-water system in college is beyond me, but things have progressed nicely.
As part of an effort to share more designs, I've decided to start writing a continuing series of blog articles on my hardware design efforts. This first article covers the NixieBoost of a NixieView.


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Board of Trustees
Welcome to our school
Welcome to Ashgrove School. We are extremely proud of our children, the school and the achievements they make together. Our common mission is to provide a quality education in a positive environment which encourages learning for life.
Gary Stevenson
Board Chair / Maori Committee
Megan McNay
Deputy Chair / Communications
Jason King
Leanne Speirs
School Docs / RAMs
Matthew Van Tuinen
Personnel / School Docs / RAMs
Shaun Fauth
Health & Safety
Christine Chadwick
Andrea Woolford
Staff BOT Representative
The board is made up of parents who have been elected in the triennial elections. Other trustees may have been co-opted on to the Board for their specialist skills or elected to the Board by selection due to a Trustee resigning. The Ashgrove Board of Trustees is normally made up of six parent trustees and two school trustees, one being the Principal and the other a staff trustee. A Board Secretary also collates meeting agendas and minutes the Board meetings. If you are interested in what your Board does please feel welcome to attend any of our meetings.
Parent trustees are delegated portfolios of Property, Treasurer, Health & Safety and Human Resources and take responsibility for the overall Governance of the School. The Board sets and reviews policies which guide the Principal and staff in developing procedures for the development of our children and running of the school.
A Board key focus for this year is the planning for the improvements to our school. With the completion of the Mahuri and Tipu blocks the benefits of Modern Learning Environment / Modern Learning Practice is apparent with collaborative learning and inquiry developing our students' skills to succeed.
The Boards other objectives include:
- Completion of Stage 2 and 3 of the new playground
- Defining the 5 Year Property Plan
The Board is thankful for the hard work the School PTA does to raise funds for the school, be it Restyle Me, second hand uniform sales, and the Christmas Gala. Without the huge contribution of the School PTA items such as the new playground would be that much harder to fund.
The Board enjoys having the Allenvale School Satellite Unit within Ashgrove School and we look to both of our schools learning from each other and our students growing together.
Our gratitude goes to our staff who work tirelessly throughout the year for our children. Their ongoing development and sharing of ideas models the strong values of our school.
If you are a parent of a prospective student I welcome you to visit our school to see what Ashgrove has to offer.
Gary Stevenson
Chairperson, Ashgrove School Board of Trustees


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MONTREAL – Montreal taxis will take on a new, uniform look this spring, and their drivers will also take steps to green up their ride, city of Montreal officials announced yesterday.
The deal reached between the taxi industry and the city administration means taxis will be allowed to mount an advertising panel on their roofs, along with a uniform taxi light designed specially for Montreal cabs.
Within six years, all Montreal taxis will have to be the same colour, although that colour has not yet been agreed upon.
"For several years, our administration has been wanting to reach an agreement with the taxi industry on a Montreal identification for the cabs," said Manon Barbe, the city's executive committee member responsible for transportation.
In return for being allowed to reap advertising revenues from the rooftop panels, taxi drivers will have to abide by a number of environmentally friendly measures, such as installing an in-car heater so they can keep the cars warm in winter without idling their engines. (Taxis are exempted during cold months from a city bylaw that forbids idling for more than three minutes).
A greenhouse gas emission reduction program will be implemented over the next four years that will encourage taxi companies to convert to hybrid vehicles.
A design contest will be launched by the city to create a uniform taxi stand design.
"Currently taxi stands have little visibility and are difficult to identify," said Helen Fotopulos, executive committee member responsible for culture, heritage and design.
The public will be invited to vote for a winning design, Fotopulos added.
"The taxi industry has seen a drop in ridership of 30 per cent on average and needs new revenue sources," said Mario Sabourin of the Travailleurs autonomes du Québec, which represents independent owners of taxis, welcoming the new agreement.


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I've mentioned a time or two that I'm working on a historical series that correlates with the ghosts in my Book B!tches series. They are unedited, although their draft form is pretty complete. Please leave a comment or contact me at firstname.lastname@example.com with thoughts. I will post one chapter a week. I hope you enjoy!
Chapter one
June 12, 1865
Emily felt the change in the air before she saw the dust rising on the road. She'd woken up with an itchy feeling of anticipation she couldn't explain. So, while unexpected, the plume of dust on the road leading up to her house didn't exactly surprise her. As she pumped water from the well in the yard for wash day, her hands worked faster, trying to fill the bucket as her eyes scanned the horizon. It wasn't the tall, billowing plume of a wagon or horses, but it was larger than the plume Mr. Stein had made yesterday. Which meant it was more than one person, most likely on foot.
A tingle of apprehension stole up Emily's spine. Strange things had been happening in Texas since the war had ended, and she and Mama had been trying to hide the goings on from the rest of the kids, so as not to worry them. Banks had been robbed, stores looted, and farms raided. Every time one of them went into town, more bad news awaited them. Fortunately, Brantville had been spared, so far. But news of King Springs, a mere forty miles away, was dire.
Jamie came racing through the trees into the yard, breathless and flushed. "Emily! It's soldiers! Soldiers are coming!" He didn't stop, his excited state propelling him into the house, while Emily braced herself for trouble. The war was over, but that didn't mean her world was at peace. She wondered when it ever would be.
Her heart pounded, wondering what soldiers would want with them, and she forced air into her lungs. They were on a private drive, not the main road, and anyone coming this way would have to have their farm in mind for a destination. Breathing heavier than necessary, Emily watched as the dust heralded the arrival of several men, limping into her family's yard. Emily knew with a sickening sense of foreboding, that this group of men heralded more than just an arrival. The presence of these soldiers illustrated a change for her family, whether she liked it or not. That was the feeling she'd woken with this morning. It was a sense of doom, because the axis of her world was tipping even further from the comfort level of her past she longed with all her heart to get back to.
When the rag-tag bunch approached, one man walked forward, the dust unable to hide the markings of a Union soldier.
"Sergeant Major Breck, at your service Madam." The man bowed low, swiping his cap off his head and clutching it to his chest reverently. Emily found herself in a brief curtsy as a response, even though she had no real reason to be civil to this man, but she was too scared not to be. She could name twenty reasons to be frightened, none of which she would actually voice. So Emily stood as stoicly as she could, lifting her chin.
Her eyes roamed the men behind him, about twenty in all, looking like an awful mess. Five or six men were managing to hold up the rest of them, obviously ill. The war was over, and they were on their way home, back North. She couldn't imagine what all was wrong with them. They looked sick, tired, and hungry. Even through the warnings going off in her mind with the knowledge they were the enemy, a sense of pity pervaded. Were Papa, John, and Jakob going through the same trials to get back home? Were they as sick and wounded as these men were? Were people being nice to them, in an effort to get them to leave and come home to their families?
"I am Rachel Evans, and this is my family's farm. My daughter, Emily." Mama had made her appearance on the porch, and her regal disposition shone through the rugged exterior, awing Emily. Her mother worked harder than any woman she knew, yet she'd come here with Papa from New York City years ago, and her polished background managed to shine through when needed. Like now. Her rigid spine and elegant demeanor belied the threadbare dress she wore.
Something in her tone spoke of a kindred spirit to the Yankee and he smiled before bowing even lower to Rachel. Rightfully so, because Emily only wanted to shoo them away and tell them to send her men back.
"We are in need of food and lodging. We are trying to make our way back home, ma'am, but most of us are sick. Just until we get on our feet, if you please." Emily couldn't be sure, but it seemed his words spoke plainly, even while his expression was calculated. His eyes darted about, inventorying the farm, the barn, and the surroundings. She wanted to extend her arms and pull the entire property into them, to keep it all hidden from his curious gaze. First the bank was trying to take it away, and now this man was here, looking around like he suddenly owned the place. Her hackles rose, but her mother's next words had her snapping her head to look at the woman.
"Of course. You may make lodging in the barn. Stay as long as you need. Emily will be out in a moment with food and supplies." Chin raised, Mama dismissed them and walked into the house, tugging on Emily's sleeve to follow.
"Mama!" Emily hissed under her breath when the door was closed. If her heart pounded before, it was now galloping out of her chest. It was almost as if she stood in front of a stranger. The stories she'd heard of Yankee soldiers raping women on the road they'd come across were horrific. Her mother was inviting them to stay? "What are you doing? They're Yankees!" She cried urgently, unable to not state the obvious. Her past, tied with her future, was slipping away with every minute of this day. Each new action proved to her that she would never find her old life again.
"I know, child. Don't sass me." Softening her tone, she continued. "The bank is coming in two days. I doubt they want to take back a farm that's overrun with Union soldiers."
Emily's gaping mouth snapped shut, speechless at her mother's wisdom. Once again, she realized she didn't know as much as she thought she did. Of course, the entire country side had heard the horror stories. Nobody would want to be around the soldiers. The two women turned to the kitchen, where Jamie and his two sisters, Louise and Irene were staring at them, slack-jawed, Irene holding her beloved rag doll in her mouth, as she did when she was upset.
It was a tricky plan, one that could backfire on them. They may indeed get to keep their farm, but at what cost? If the soldiers ate all the food before winter came, the Evans would have nothing. By the time the soldiers took their leave, would there be a farm left? There wasn't anything to be done for it. They could comply, or they could boot them off the place, and apparently Mama had made her decision. The soldiers would stay.
Emily smoothed down her skirts, in a concerted effort to calm her nerves.
"You're catchin' flies…" Emily muttered as she walked over to the stove to start piling corn cakes on a platter for the soldiers. This was supposed to be their supper, but they'd have to make more. Scooping up the pitcher of buttermilk and stuffing a sheet under her arm, she walked to the door. Her mama started barking orders at the children to fetch eggs, make more corn cakes and pick some tomatoes from the garden. Apparently Mama was going to feed them well.
Emily quieted her thoughts, managing to balance everything and still grab the bucket of water on her way to the barn, determined not to grumble, but when she arrived, the scene stunned her.
The men had looked rough before, standing in her yard, but they had been hanging on to a tenuous thread of dignity. Now, they just looked pitiful, either lying in heaps on the floor of the barn, or sitting, obviously exhausted. She handed off the plate and pitcher to one of the men, who took it gratefully with a mumbled, "Thank you, Ma'am."
Overwhelmed by the sight in front of her, Emily struggled to know what was next. They had a place to stay, as well as the Evans' dinner. Now what? The men who looked able, barely looked able for anything. Fatigue marred their every motion, from passing the plate and pitcher, to stretching their legs. The ones who didn't look able, looked next to death, and Emily didn't know if there was anything to do for them.
"Gentlemen," Rachel barked from behind Emily, startling the able men to some semblance of attention. "I need you to smell less, so if you would oblige, I'll be needing your clothes in a pile." She pointed to one man. "You, collect everyone's clothing and leave them in the yard, my daughters will wash them and get them back to you." Turning to Emily, she continued, "You and I will strip the ill ones."
"But ma'am…" began one soldier, clearly embarrassed.
"No need. We're married. Ain't nothing we haven't seen before." Emily had no idea how, but she managed a straight face through Mama's bald-faced lie. She wasn't any more married than Louise. Well, maybe a little more, since she was engaged, but that didn't mean she was up to stripping a bunch of strange men. The heat on her face could easily be blamed on the June sun, but she knew the truth. "If you can walk, I'll expect you to walk yourself down to the creek for a bath. There's soap there." She pointed to a small pile of soap she'd brought before turning clear blue eyes on Emily, who knew better than to argue that she wasn't married and hadn't seen any of this before. "You'll wash as you go, Emily. You get the lice out of their hair, and I'll do the rest. These boys need to be clean, first and foremost."
Emily gulped past the lump in her suddenly dry throat. "All the way, Mama?" she whispered.
"All the way, child," her mother responded with gentleness she rarely showed. Rachel must have read her trepidation, because she went a bit further to allay Emily's fears. "I'll explain later, Emily. Just do this now." Mama's mouth was set in a stern line, her shoulders straight. She clutched her skirts and went to work.
Pretending she was playing with her rag doll from childhood, Emily began undressing the men, most of whom had slipped into unconsciousness as soon as they were prone, doing her best to not look at their privates. But she just couldn't help it.
She had never seen a naked man before. She had bathed and changed Jamie's diapers when he was a babe, but that didn't come close to what she saw now, with these men and their hairy, flaccid, filthy appendages.
Her mother interrupted her ruminations, "They'll be more comfortable if they're clean."
So she did. She washed the beards and hair on the men's heads while her mother took charge of the parts she'd presumably already seen before. After about the third man, it became a stilted routine, and Emily was finished before she realized it. But the intimacy with such men made her guilty. Thoughts of Jakob overwhelmed her—memories of him helping her brother chop wood and mend fences, eating supper at their table, even lazy summer afternoons fishing at the creek—all conspired against her duty to her mama.
"Right then," Rachel stood, clapping her hands together. "You and the girls get to washing clothes, and I'll get Jamie to help me with supper." Emily raced away, thankful to be out of the barn, and away from the strange men.
With Louise and Irene at the wash pot, dutifully stirring the clothes for their wash day chore, Emily unceremoniously dumped the soldier's clothing in a pile on the ground. Louise carefully placed more wood under the pot, to keep the ashes from rising into it and getting the clothes dirty.
Emily fished out the girls' dresses and lost herself to her own thoughts as she scrubbed them clean while her sisters put the soldiers clothes in the pot to soak. She missed her Papa and her brother. William and John had willingly gone to go fight in the war close to three years ago, to show solidarity to their sister states of the Confederacy. Jakob had not gone until he was conscripted two years ago. They were to be married on his return.
Thoughts of familiarity, paired with the cleansing motions of scrubbing clothes, made her feel better. When the men came home, life would get back to normal. She and Jakob could get on with their plans of building a house on the property and raising a family while Jakob and her father worked the crops. Maybe they could even go back to planting cotton, like before. John would find a nice girl from town to marry. Jakob's parents would come over for a Sunday meal after their worship and Bible study, and Mama and Papa would help her make her new house a home.
Of course, she hadn't heard from any of them in over eight months, and she had no idea if that meant they were dead or not. Lots of men hadn't been heard from, but some were beginning to make their way back home now. What would Papa and John say if they came home to find a bunch of Union soldiers sleeping in the barn? What would Jakob say when he found out Emily had seen them naked? She chided herself. Jakob would never know if she didn't ever tell him. The dishonesty stuck in her craw, but she was doing her duty to her mama, and obeying her wishes. That had to count for something.
As she scrubbed the clothes on the flat rock Emily used, her hands red and getting raw from the heat of the water, lye fumes permeating the air. She found it difficult to clear her mind. She kept pondering the mysteries of men. She had felt Jakob's parts once, when he'd kissed her, he'd been hard against her hip. It had scared her a little, but she could admit she was more curious about it than anything now. Did he look like the soldiers when he wasn't kissing her? She was taken aback. How strange it must be to have that fleshy thing dangling between your legs all day.
Emily blushed at the turn her thoughts had taken. Her face was nearly as red as her hands.
Louise broke through her musings. "How long do you suppose they'll stay?"
Emily shrugged. "I really don't know. I suppose as long as Mama will let them." She hoped it wasn't very long, but by the set of tilt of Mama's head, she'd gotten an idea about them. There was no telling what was going to happen.
"I don't like them," Irene said with finality. "What if they killed Papa?" Her bright blue eyes her youngest sister had inherited from Rachel filled with tears and she clutched at her precious rag doll as if it would protect her. The rag doll had been handed down from girl to girl as one outgrew it and the next one longed for such a precious item.
"Hush now. Papa's not dead. He's just taking a lot longer to get home than he expected." Emily had been saying this so long she almost believed it. The truth was, this war had changed her life from a comfortable existence to one marred with uncertainties. And the biggest uncertainty of all was who would be here when the dust of war settled? Would her family ever be whole again?
After scrubbing the dresses, Emily draped them over the line in the yard before they rinsed them in the creek. She had to do the Soldiers' clothes next. She let out a sigh at the thought of these soldiers making more chores for her. Emily was weary enough with their own chores.
Mercifully, the girls were lost in their own thoughts, and didn't pester Emily with more questions she couldn't answer.


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Mitch Hurwitz
Mitch Hurwitz is an American television writer and producer. He is best known as the creator of the television sitcom Arrested Development as well as the co-creator of The Ellen Show, and a contributor to The John Larroquette Show and The Golden Girls.
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Sklarbro Country #168October 11, 2013
One of the fastest/funniest minds and most creative people in all of television, Mitch Hurwitz, the creator and showrunner of Arrested Development joins the Sklars for a rifftastic Sklarbro Country! Mitch talks about his time working on the Golden Girls, going against…Listen
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With Bejing on our minds, the state visit comes tonight
Singaporean Prime Minister Lee Hsien Loong
On Tuesday night, Singapore prime minister Lee Hsien Loong is expected to arrive in New Delhi on a state visit.
This is his second in a decade, and marks the close attention that Singapore pays to its relations with India.
While the formal agenda of his visit may cover issues like education and economic relations, you can be sure that the political discussions between him and his Indian counterpart Manmohan Singh will be around China.
Even as the United States promises a pivot to Asia, countries like Singapore, long friendly with Washington, worry about the increasing assertiveness of Beijing, a concern that is shared in increasing measure by New Delhi and is the key feature of the Asean Regional Forum ministerial meeting taking place in Phnom Penh, beginning Wednesday.
Standing at the proverbial crossroads of Asia, this tiny city-state can give any great power a lesson or two in geopolitics and, of course, civic administration. India may talk about its Look East policy and then get distracted by its numerous problems back home, but Singapore is deeply focused on India's role in Southeast Asia and assiduously pursues its goal.
Of all the ASEAN nations, Singapore probably has the best relations with Beijing. One reason, perhaps, is that unlike Vietnam, Malaysia, Philippines and Brunei, it does not have a maritime dispute with China.
Another is ethnicity- 95 per cent of the residents of the city-state are of Chinese origin. But the more important reason is Singapore's self-image as a nation-state.
Small it may be, but it has a clear-headed idea of its national interest, and it pursues it with great skill and determination.
Of all the ASEAN nations, Singapore also has the best relations with India, but these are not a matter of ethnicity, but its geopolitical world view. India's rediscovery of Southeast Asia began with Narasimha Rao's Look East policy which was quickly embraced by Singapore, whose prime minister Goh Chok Tong was invited to be the chief guest at the Republic Day parade in New Delhi in 1994, the year in which the policy was initiated.
From as far back as the early 1980s Singapore had seen that India and China will be the Asian giants who it will have to get along with and it has since then worked assiduously to woo both. It has continued to do so as both countries have developed economic profiles that spill outside their natural boundaries and collide in Southeast Asia.
That kind of a collision, Singapore can live with, what it worries about is a military standoff which would be a disaster for everyone, especially the city state which is dependent on open trade and financial flows for its First World like prosperity.
Since then, the city state has sought to build up connections with India in trade and business ties, as well as through strategic investments. It is not surprising that Singapore was the first country with which India signed the Comprehensive Economic Cooperation Agreement in 2005.
Equally importantly, it has sought to develop cultural and educational ties by promoting projects like the Nalanda University in Bihar. Understanding Both Singapore and the 17-member ASEAN work on two tracks-one is to encourage India to play a greater role in the affairs of the Southeast Asian region and institutions like the East Asia Summit and the ASEAN.
The other is to hope that Indian economic and military might will be able to offset, at least in some measure, the compelling power of Beijing. Singapore also works along an additional third track-promoting understanding between India and China.
This role is not insignificant since there is very little civil society interaction between New Delhi and Beijing. The Institute of Southeast Asian Studies (ISEAS), The National University of Singapore (NUS), Lee Kuan Yew School of Public Policy and Nanyang Technological University have formed the Singapore Consortium for Indo-China dialogue.
Interestingly, two of the active academics anchoring the consortium are India-born scholars of classical China- Prasenjit Duara, Director of Humanities and Social Sciences Research at NUS and Tansen Sen Director of the Nalanda-Siriwijaya Centre at ISEAS.
An example of their effort has been a series of symposiums that have brought media personnel of India and China together. At a conference last week titled "Image and Perceptions: The Role of the Media in India-China relations", two basic questions were posed: Is the media responsible for creating recent misperceptions between India and China and second, whether journalists in the two countries were trained and knowledgeable enough to cover each other.
Journalists from the Chinese mainland, Hong Kong, Singapore and India participated in the discussions and, at the minimum, gained some understanding of the way the media functions in the two countries. Institutions But beyond perceptions, New Delhi and Singapore need to evolve a common means of dealing with Beijing.
China has, in the past, tried to soothe ASEAN fears with regard to its conduct, in recent years it has been more belligerent. The instance of warning India off a Vietnamese oil concession is only one of many incidents that have sent shivers down the ASEAN spine. Neither New Delhi, nor Washington, Tokyo and the ASEAN capitals have a good idea of how Beijing can be tackled. As of now the bets are on institutional frameworks like the ASEAN and the East Asia Summit.
The 19th ASEAN Regional Forum (ARF) ministers' meeting and the 2nd East Asia Summit foreign ministers meeting is taking place in Cambodia. The ARF established in 1994, is the key forum for a security dialogue in Asia involving the ASEAN, as well as China, India, EU, Japan, Russia and the US. No doubt some of these issues will form part of the discussions between India and Singapore on Wednesday.
Hopefully with a bit of Singaporean geopolitics and some growing Indian determination, Beijing can be nudged to play by the rules of international conduct to its own benefit, and that of the region.


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I have a new pattern that I have been working on today! My poor kiddos, I totally ignored them. I was so excited to work on this, and they were playing so well, oops.
I need your help, please leave me a comment and your email address if you would like to test my pattern. You get the pattern for free! Please get it done quickly and give me your HONEST feedback.
Leave a comment with your idea for a name for this purse, too!!


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0Exactly. Only the kid was found a few weeks after. He supposedly said that the spot wasn't peaceful anymore.Flag ShepatitisMon October 27, 2011
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For the better part of a century, antibiotics have given doctors great powers to cure all sorts of bacterial infections. But due to bacteria's nasty habit of evolving, along with widespread overuse of these drugs, disease-causing bacteria are evolving antibiotic resistance at an alarming rate, making it much harder, and at times impossible, to wipe them out. DARPA, the military's research agency, is eyeing an innovative solution to the problem: Rather than struggling to make better antibiotics, ditch them altogether. It may be time to start killing bacteria a whole new way.
What's the News: Researchers found that squalamine, a steroid present in the bodies of the dogfish shark, has a protective effect against several human viruses, all of which are difficult or impossible to cure with existing drugs. The chemical has so far been shown to be relatively safe in humans and can be synthesized, suggesting it could have promise as an antiviral drug in humans.
Fenugreek seeds
The European Food Safety Authority has released a scientific report on the deadly E. coli outbreak that has sickened more than 3,500 people and killed at least 44 in the last seven weeks, and the news is grim: the apparent source of the contamination, a shipment of fenugreek seeds from Egypt, has been scattered all across the continent, making recall tricky and new outbreaks likely until the seed packets reach their expiration date in three years. Maryn McKenna of Superbug expertly breaks down the report in all its chilling detail:
Could Neanderthal DNA have protected our ancestors from diseases?
What's the News: While we humans have certainly outlasted our hominin cousins, new research shows that Neanderthal and Denisovan genes may have helped us spread far and wide. By mating with the two species, our ancestors acquired genes that allowed them to adapt to diseases outside of Africa far quicker than would have been otherwise possible, according to Peter Parham, a professor of microbiology and immunology at Stanford University.
What's the News: A massive outbreak of E. coli is spreading through Europe, with 17 people dead in the last two weeks and 1,500 people sickened in Germany alone, where the outbreak began. Authorities are still trying to figure out where the outbreak originated and how it can be treated.
Virions from a smallpox vaccine
What's the News: Global health officials are expected to decide whether to destroy the world's last caches of smallpox at the 64th World Health Assembly this week. The disease was declared eradicated by the World Health Organization in 1979, but two small stores of the virus remain: one at the Centers for Disease Control and Prevention in Atlanta and one in a Russian government lab.
Now, public health officials are divided on how to ensure that the disease stays eradicated. Some say our best bet is to keep the remaining samples of the virus safe and continue to study them, then destroy them at a later date; others say the safest course is to destroy them now, once and for all.
The bacterium called Neisseria gonorrhoeae is what gives humans the sexually transmitted infection gonorrhea. And it also takes something: human DNA. Northwestern University researchers report in the journal mBio that they've found pieces of human DNA in samples of the bacteria.
Gonorrhea is one of very few diseases exclusive to our species, and is one of the oldest recorded diseases in human history. An ancient disease that resembles gonorrhea's symptoms is even described in the Bible, according to Hank Seifert, senior author of a paper on the gene transfer. [Popular Science]
Seifert and colleague Mark Anderson looked at 14 different samples of N. gonorrhoeae. Three of them possessed the chunk of human DNA. And they only saw it in the gonorrhea bacteria:
The pair looked for the same human DNA fragment in the genetically related bacterium Neisseria menigitidis, known to cause meningitis. "We screened many isolates and it wasn't present," says Seifert. That means the transfer to N. gonorrhoeae must have occurred since the two bacterial species diverged around 200,000 years ago. [New Scientist]
Swarms of genetically modified mosquitoes? This isn't science fiction: The Malaysian government announced earlier this week that it unleashed 6,000 genetically modified (GM) skeeters into a forest as part of a plan to fight dengue fever, a potentially fatal affliction that can affect up to 100 million people each year.
The news appears to have caught the Malaysian media and public by surprise; many recent news stories reported that the study had been postponed after intense protests. As recently as 17 January, the Consumers' Association of Penang and Sahabat Alam Malaysia, two groups opposing the use of GM insects, called on the National Biosafety Board to revoke its approval for the study. Scientists, too, were under the impression that the work had yet to begin, says medical entomologist Bart Knols of the University of Amsterdam. A 24 January blog post by Mark Benedict, a consultant at the Centers for Disease Control and Prevention in Atlanta who monitors the field closely, mentioned that the Malaysian study was "planned." [ScienceNOW]
The study itself included the release of 12,000 male mosquitoes in total: 6,000 unaltered and 6,000 GM Aedes aegypti mosquitoes. The goal was to track how well the two types survived and how far they spread. U.K. biotech firm Oxitec created the modified mosquitoes, which don't produce viable offspring. Researchers hope that if these altered males mate with wild females, it will bring the overall mosquito population down. The strategy has been tried once before in the Grand Cayman Islands, and results from that experiment are due to be published soon.
Around two million people die each year from TB, and the bacterial infection is startlingly widespread—the World Health Organization says about one in three people around the world carry Mycobacterium tuberculosis (and humans may have been carrying it around for at least 9,000 years). Thankfully, TB is latent in the vast majority of these cases. But tuberculosis' pervasiveness presents the question of just how the bacteria evades our immune system to set up shop on a long-term basis.
According to a study led by Gobardhan Das in the Proceedings of the National Academy of Sciences, stem cells might be the answer. Particularly, mesenchymal stem cells (MSC).
TB recruits mesenchymal stem cells to the lungs, where they help suppress the immune system that fights disease… The stem cells produce nitric oxide, a chemical that reduces the type of white blood cells called T-cells, the researchers wrote. [Bloomberg]
A new study is providing insights into the 2009 swine flu epidemic, and why more serious complications arose in healthy middle-aged people than expected. The researchers say the culprit may be antibodies to seasonal flu found in the seriously ill patients, which might have caused an immune system overreaction in the lungs.
"Nobody really had a good explanation for why middle-aged people seemed to have more severe disease than would have been expected," says Richard Scheuermann, an immunologist at the University of Texas Southwestern Medical Center in Dallas. "This explanation is the first one that I've seen that actually makes sense." [Nature News]
Normally, severe flu illness happens in the very young (who haven't been previously exposed to the flu and don't have protective immunity) and the elderly (who have weakened immune systems). Instead of affecting these groups, the 2009 pandemic H1N1 "swine flu" primarily caused severe reactions in middle-aged adults.


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3 pointsJunior
Ride intended for ages 6+
Height Requirement 42″ (unless accompanied by a chaperone)
Ride along with Rescue Pack on another wild animal rescue adventure! This Rescue Rider bus will swing you round and round to help Diego on his journey.
Chaperone policy: A chaperone is defined as a person who is qualified to ride and who, in the opinion of the ride operator, is capable of controlling the actions of the unqualified rider. Required chaperone does not pay to ride.