text:
Project 1 is a experimental furniture project which mainly focus on the conbination of different materials such as bamboo, stainless steel and rattan.
The frame of table was assembled by three way pipe connected with bamboo.
A bamboo board was fixed on the top as surface by Artifical rattan.
Same structure was applied on the land lamp with illumination system (COB light bar) built inside, which gives a nice atmosphere.


text:
Pure Crap.
Gameplay: The controls our worst then Pre-RE4 controls. When a game has worst controls then a Resident Evil game ( All the ones before Resident Evil 4) then it sets a new low in gameplay & that is exactly what is game does. I found myself getting extremely mad at this game during the "Battles". Oh in case your wondering it takes about 10 seconds to get into the battle. Once in a battle you then realize that you control Orphen & only Orphen. You have no control over anyone else, Which would not be a problem if the Ally A.I. was smart. Well guess what it is not smart at all. You could be on the brink of death & they would just continue to attack the enemy. Let me just finish this off with: the gameplay is nothing, but CRAP! Now let's move on.
Graphics: No I have moved on from Crap to horrid. What were the developers on when they were making this? This has got to be the game with the worst graphics on the Ps2. When they talk the move in patterns, & their lips don't move yet they speak (more on voice acting later). I really don't know what else to say about the graphics. Let me leave it at that.
Sound: Let's start off with Voice Acting. What is that coming out of their mouths, why that sounds like CRAP (I would say something else, but I trying my best to keep it clean) who did they hire for the voice acting? Who ever they were they need to be shot. Not even criminals should be force to hear this CRAP. Moving on to the soundtrack, AHHHHHHHH! Why did they do this to the game? This game does not need anything else to go against it. I out of things to say you can pretty much guess what I will say about the sound. CRAP!!
Verdict: There are two reasons to get this (not both) 1) To place it into a collection or 2) To say you have played the worst game okay not the worst, but the second worst game in history of fun.

subset: commoncrawl


text: Señor Grumblecakes (jervo) wrote, 2001-10-02 14:43:00 Señor Grumblecakes jervo 2001-10-02 14:43:00 Previous Share Flag Next *sigh* I've been back in the working world for 12 hours and I'm already losing my mind. I hate doing stupid work. There are certain kinds of work here that I don't mind doing, like editing documents and updating time sheets; but then there's the utterly ridiculous stuff, like creating file folder labels and trying to find a padded envelope because one of the lawyers has to send a hotel key back to Rome because his wife accidentally forgot to return it when they were checking out - goddamn, I'm tired of it. Subscribe Post a new comment Error Comments allowed for friends only Anonymous comments are disabled in this journal We will log you in after post We will log you in after post We will log you in after post We will log you in after post We will log you in after post Anonymously switch LiveJournal Facebook Twitter OpenId Google MailRu VKontakte Anonymously default userpic Your reply will be screened Your IP address will be recorded Post a new comment Preview comment Help 3 comments Post a new comment 3 comments


text:
German engineering and construction services firm Bilfinger recently issued its fifth straight profit warning, and its power division, which builds and services conventional power plants, is facing major upheaval.
But the firm isn't considering selling the division, Handelsblatt has learned; rather it is focusing on a significant reduction in its size.
Entire areas must be restructured and reoriented, new supervisory chairman Eckhard Cordes told a shareholders' meeting.
Soon-to-depart chief executive Herbert Bodner is handing over a huge task to his successor, Per Utnegaard, who takes over on June 1. Bilfinger, based in Mannheim, has three divisions, but only its facility management sector is doing well. That division constructs, operates and maintains buildings such as shopping centers.
The industrial division, which maintains and modernizes facilities and is also involved in drilling for oil and gas in Norway and the United States, is barely profitable. The power division is disappointing on all counts.
There is a need to make a clean sweep. They require an entirely new corporate culture. Marc Tüngler, DSW private investor association
Cevian, an investment firm with a large shareholding in Bilfinger, is putting pressure on the company. It wants to see a rise in share price over the mid-term. But that seems unlikely. "That's why there's a bit of an unsettled mood at the moment," an insider said.
First of all, Mr. Utnegaard must tackle the failings of the power division. The situation is bad with regard to the construction and maintenance of power plants, because of the "ongoing uncertainties in energy policy," Mr. Bodner said recently.
The disaster at Japan's Fukushima nuclear power plant in March 2011 is causing great uncertainty in Germany's conventional power business, as the country phases out both fossil fuel and nuclear power production. This means energy companies aren't making new investments.
The power plant sector's woes are hard to manage. The large size and high risk of power division projects has meant that Bilfinger has had big problems in project management. Mr. Utnegaard's short-term solution is job cuts.
Mr. Bodner said a possible option is the closure or merger of parts of the division, which employs 11,500 of Bilfinger's 69,000 workers worldwide. Above all, German sites with a total of 3,700 employees must be scrutinized to see if they remain economically viable. The German arm of the power division has been responsible for the biggest decline because of the country's move to renewable energy.
The second point on Mr. Utnegaard's to-do list is to re-energize the industrial division, despite the fact it has already enjoyed some success. For example, the company recently extended service contracts with Shell worth €150 million ($167.2 million). The deals are related to Europe's largest refinery in Rotterdam as well as the petrochemical site in Moerdijk, both in the Netherlands.
The low price of oil is causing problems with projects in Norway and the United States. Revenues are much less than expected. "These are not small sums," Mr. Bodner said recently.
Service contracts can be troublesome. "Many customers have a sort of framework contract with Bilfinger for certain services that can be called for when the customer wishes," said Marc Gabriel, an analyst at Düsseldorf-based bank Bankhaus Lampe. That is difficult to manage because employees must always be on standby.
Bilfinger also has problems of its own making with its project management business. Company sources say it has sunk many millions in the sector over the years, but has put too much faith in people who have no experience. The inside word is the supervisory (non-executive) board didn't monitor developments closely enough.
Marc Tüngler of DSW, Germany's largest private investor association, puts it more bluntly: Apparently, top management was no longer aware of what was happening in its business operations. "There is a need to make a clean sweep. They require an entirely new corporate culture."
Consultants from McKinsey are looking for possibilities to make crucial improvements in project management. Mr. Utnegaard may be the man to do it. Between 2007 and this month, he was the head of Swissport International, a large provider of ground handling services to the aviation industry. The firm is active in 45 countries.
During Mr. Utnegaard's term, Swissport became the leader in its field and embarked upon a "remarkable" course of growth, as stated in a notice from Bilfinger.
The restructuring, however, will be long and painful, something that doesn't seem to shock Mr. Utnegaard. "I am enthusiastic. There is much to do," he said.
Jens Koenen leads Handelsblatt's coverage of the IT and aviation industries, Martin Tofern is a news editor. To contact the authors: [email protected], [email protected]


text:
Kim woo bin and lee jong suk relationship poems
Lee Jongsuk Talks About Close Friendship With Kim Woobin - CLEO Singapore
School is a South Korean television series starring Jang Nara, Choi Daniel, Lee Jong-suk and Kim Woo Bin. The teen drama depicts the struggles. Kim Woo Bin was spotted for the first time since his cancer treatments, vacationing in Hawaii with his close actor friend, Lee Jong Suk. May 14, And each of these relationships is treated with nuance and care. . And then, there's the awesome poem that Nam Soon quietly recites for Young .. And Kim Woo Bin and Lee Jong Suk don't shy away from engaging in and.
Someone who is considerate to others, someone who is trying to understand others. I lowered myself in front of people, I want to learn to believe. I often think about it that way. Is there any other twisted charms that you had? On the internet, I saw an article that analyzed why Kim Woobin resembles a dinosaur.
Even when I see it myself, I do think I look a little bit like dinosaur. There will be White Day in two months, what are your charms as a boyfriend? I also got a good sense of humor, and I have a lot of aegyo. Lastly, name 3 things that are important to kept in mind in order to keep your love to last long. Trust, consideration, and understanding.
Lee Jong Suk And Kim Woo Bin Spotted Hanging Out Together
So you yourself already had these 3 qualifications? Ei, how am I supposed to know that. The other person is the one who should know whether I have it or not. Actually, since I also play a rebellious student in my past work, I was a bit hesitant.
I also worry if my image would get lost among the very strong sunbaes that participated in the past series Ceci: It must be quite stressful to be a part of famous series dramas? In the beginning, I was quite scared because of the stress.
Photos Of Kim Woo Bin And Lee Jong Suk Vacationing In Hawaii
At first, the director wants me to be like Jang Hyuk sunbaenim, and even my very presence would exude justice and charisma. He learned about the world too early, and cares for nothing. In the beginning, rather than saying I got into character, I was learning from my character — he is like air, without particular strength. I would also go to the monitor rooms and learn a lot from rewatching the shots. Same as Kim Woo Bin, you speak of the help from the directors a lot.
They are really wonderful. Later, I heard that the director said the same thing to the other actors. That is a leadership quality that can conquer hearts. Do you remember the moment when you felt the role fit you like clothes?
This is what it feels like to be at one with your character! As a person who had graduated from the school uniform five years ago, which parts of the character resonates with you?
Lee Jong Suk And Kim Woo Bin Spotted Hanging Out Together
It is probably different from the perspective of the audience. I started being a model when I was in high school, so my working life began relatively early. Rather than searching out my dream, it was more important to discover how to realize my dream.
Which is to say, while my friends would fight over console games and stuff, I would find all that very childish. Probably since there are similarities, you can act as him so well. Due to your performance, Namsoon has received a lot of discussion recently. Your popularity is so high that there are even scandals.
Yeah, thanks to the popularity. I was only going for a trip after the drama ended. My brother planned a trip to Japan and my schedule was open right at that point so I went with him. Are there any other misunderstandings that happened? On the contrary, it seems like some misunderstandings were cleared up.
But one of the biggest reasons why everyone is watching K-dramas from every corner of the world right now is because there's no shortage of talent in South Korea's entertainment industry. Competition for the role was reportedly so intense that after multiple callbacks, Min Ho found out about his casting through a newspaper!
Jun Pyo is hot-tempered, extremely arrogant, and unable to express his feelings well. So when a new student named Geum Jan Di Ku Hye Sun —who was offered a scholarship at the rich kids' school after she saved a student from committing suicide—dares to stand up against him, Jun Pyo proceeds to torment her, only to realize that he's actually fallen in love with her. He ends up in a not-so-bitter rivalry with his best friend Yoon Ji Hoo Kim Hyun Joong and has to fight for his love for Jan Di amidst schemes from his disapproving mother.
Audiences see Min Ho laugh, cry, and make cute faces in Boys Over Flowers, and it became a starting point for him to star in other big dramas and films such as City Hunter, Personal Taste, and Gangnam Blues. Due to the show's popularity not just in Korea but in other Asian countries like Philippines, Taiwan, and Vietnam, the drama's local filming locations such as the Damyang Dynasty Country Club and Ragung Hanok Hotel became tourist attractions.
It is a historical romance set during 19th-century Joseon Dynasty and is based on the novel Moonlight Drawn by Clouds, written by Yoon Yi-soo. He's adorable, smart, unpredictable, and a little mischievous, which makes most of his servants dislike him.
Also, he's into arts and music! The story revolves around Prince Lee Yeong and his struggles as he falls in love with one of his eunuchs Hong Ra On Kim Yoo Jungwho's actually a girl crossdressing as a man. Popular and street-smart Hong Ra On was raised as a boy by her mother and made a living by disguising herself as a male relationship counselor and romance novel author before becoming a eunuch to the prince. Although the girl-dressed-as-a-boy trope has been done several times already, Bo Gum and Yoo Jung's chemistry made it work and the drama was well-received both in Korea and the Philippines.
He was also part of the ensemble cast of Replywhich aired from to In the show, Si Jin is in the military while Mo Yeon is a doctor, and while they are visibly attracted to each other and even go on a few dates, they come to the conclusion that they just can't make the relationship work.
Months pass and they meet again after Mo Yeon is forcibly sent to do volunteer work in Uruk where Si Jin is leading a military station. What follows is a series of crisis situations where the two must work together. Needless to say, everyone fell in love with Joong Ki after watching him play Si Jin.
After all, who doesn't love a man in uniform? But did you know that Joong Ki got injured towards the end of the series? He returned after just two weeks to shoot his remaining scenes even though his injury wasn't fully healed he couldn't walk properly!
Due to the show's success in China, their government reportedly issued a warning about the "dangers" of obsessively watching Korean dramas through their Weibo account. By the way, he's actually an alien with supernatural powers who can teleport and stop time! After the girl dies from saving him, Min Joon is resigned to living in isolation for centuries as he waits to return to his original home planet.
Lee at the Vogue Fashion's Night Out. According to the related personnel from the drama: Originally slated for 16 episodes, the drama was extended by 2 episodes due to its successful ratings. He received the Excellence Award in the male category at the Korea Drama Awards for his acting performance in the drama as well as the Best Couple Award together with his co-star Lee Bo-young.
He portrayed the character Woo Sang, an ambitious young swimmer who always strives to be 1. The movie is set in an agricultural town in Chungcheong back in the s and focuses on the lives and loves of several high school students.
It's Lee's second film as the lead actor as well as his role as a high school student.
School - Wikipedia
He plays Park Hoon, an intelligent doctor who came from North Korea, but who gets shunned because of his background. Furthermore, the drama was made available for online streaming on both Youku and Tudou where it received million and 50 million views, respectively.
Due to the drama's success in China it was planned to edit the drama into a film and release it theatrically exclusively in China with an alternate ending. The drama portrayed the passionate pursuit of justice by young news reporters on the social affairs desk.
Lee plays the protagonist Choi Dal-po, a first year reporter at a broadcasting company who struggles with the idea of justice and truth in a world where everyone wants to hide the facts.


text:
Religiously speaking, should Ethan and I have a baby?
I'm almost 7 weeks pregnant with my imaginary firstborns (twins) who were conceived by imaginary immaculate conception and their father is a filthy rich pro-football player I happened to be in love with, but I want to have Ethan's babies now.
How can I make this babies originally his? Should I go back in time or wait until they're born and become knocked up again?
Also... do you mind? *asks very nicely* didn't post: http://answers.yahoo.com/question/index;_ylt=Ag7nC...
10 Answers
- Anonymous9 years agoFavorite Answer
I can't Princess. You know Cassie wouldn't appreciate our love-child.
But I know Cassie is a very reasonable person, and is open to the prospect of threesomes. So if we have a threesome, and I "accidentally" slip and make you pregnant, I don't think that would be so bad.
But if you don't feel comfortable with sex, you know where my bedroom is, and you'd only just have to bring along your turkey baster.
- 9 years ago
I have a great idea... just add an imaginary triplet!
Yes... I said it... you are now officially pregnant with Ethans imaginary baby AND the Tim twins. I mean... really, who would want to be knocked up (even imaginary) for 18 months. It's just too much to ask of you.
- 9 years ago
Remember the who would be the R&S Octomom question a wee while back?
If you take up UP's excellent suggestion as your methodology, you could have your own litter in a matter of months. Given the fertility of your imagination, that should be quite simple. I'll volunteer to imaginarily help you raise them. I imagine you'll be able to find plenty of others as well, like a certain Aunt and Uncle. UP and Gandalf would be brilliant imaginary grandparents too.
Yes, you'll need to have more than two to go around...
- Anonymous9 years ago
<sigh> I am so tired of having to answer this question. For the last time, here it is...
What you need is to obtain a temporal anomaly permit for your uterus which will allow just your ladyparts stuff (not all of you - you're not going to be allowed to actually go back and consummate this in person with Ethan in the usual squeak-the-springs way) to go back in time and obtain Ethan's Lovegunk™ to impregnitate your bodacious self and then return your precious privates to the present time where you'll be 7 weeks up the creek but this time with Ethan's paddle instead of Timmy's. I can't believe I'm still giving all this advice away for free.
- How do you think about the answers? You can sign in to vote the answer.
- xanzibarLv 79 years ago
Well, that's the miracle of imaginary immaculate conception, you can actually change the father whenever you want.
What you can do is start a whole new imaginary pregnancy right in the middle of this one.Source(s): hope that helps ♥
- 9 years ago
I see what you did there....
- 9 years ago
Of course. Having a baby is a wonderful thing. Go for it :)
- 9 years ago
Can you tell me what drugs you are on. They sound great!
- Anonymous9 years ago
can I have your purity ring
- 9 years ago


text:
Free Ride
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Bridal Transport - Wedding Limousines - Bride and Groom Transport - Groom
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Beaches can be one of the most romantic settings for a wedding. Many girls (and boys) dream of a wedding at an exotic location such as a beach or a mountaintop. And what better season than the summer ........ Read More
Bridal Gowns – How To Find The Perfect Wedding Dress
Style, colour and ceremonial importance of the bridal gown worn by the bride during the wedding ceremony depends upon the culture and religion of the couple getting married. White is the preferred co........ Read More
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Weddings are a very exciting time. The bride and groom, as well as friends and family are waiting patiently for the big day. As a tradition, the bride and groom have gatherings with their closest frie........ Read More
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With wedding season gearing up, it's a sure bet that someone you know will be tying the knot this year. Whether the bride is a friend, a relative, or a relative-to-be, as a woman you're bound to be i........ Read More
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OBJECTIVE: A genome-wide association study (GWAS) was conducted to shed light into the genetic background influencing the development of cardiovascular (CV) disease in patients diagnosed with rheumatoid arthritis (RA). METHODS: After quality control and imputation, a total of 6,308,944 polymorphisms across the whole genome were analysed in 2,989 RA patients from European origin. Data on subclinical atherosclerosis, obtained by carotid ultrasonography through assessment of carotid intima-media thickness (cIMT) and presence/absence of carotid plaques, were available for 1,355 individuals. RESULTS: A genetic variant of the RARB gene (rs116199914) was associated with cIMT values at the genome-wide level of significance (minor allele (G): beta (ß) coefficient=0.142, P=1.86E-08). Interestingly, rs116199914 overlapped with regulatory elements in tissues related to CV pathophysiology and immune cells. In addition, biological pathway enrichment and predictive protein-protein relationship analyses, including suggestive GWAS signals of potential relevance, revealed a functional enrichment of the collagen biosynthesis network related to the presence/absence of carotid plaques (GO:0032964, PFDR =4.01E-03). Furthermore, our data suggest a potential influence of the previously described candidate CV risk loci NFKB1, MSRA and ZC3HC1 (P=8.12E-04, P=5.94E-04 and P=2.46E-04, respectively). CONCLUSION: Our study strongly suggests that genetic variation within RARB contributes to the development of subclinical atherosclerosis in patients with RA. This article is protected by copyright. All rights reserved.
OBJECTIVE: Data on the role of tobacco exposure in systemic sclerosis (SSc; scleroderma) severity and progression are scarce. We aimed to assess the effects of smoking on the evolution of pulmonary and skin manifestations, based on the European Scleroderma Trials and Research group database. METHODS: Adult SSc patients with data on smoking history and a 12-24-month follow-up visit were included. Associations of severity and progression of organ involvement with smoking history and the Comprehensive Smoking Index were assessed using multivariable regression analyses. RESULTS: A total of 3,319 patients were included (mean age 57 years, 85% female); 66% were never smokers, 23% were ex-smokers, and 11% were current smokers. Current smokers had a lower percentage of antitopoisomerase autoantibodies than previous or never smokers (31% versus 40% and 45%, respectively). Never smokers had a higher baseline forced expiratory volume in 1 second/forced vital capacity (FEV1 /FVC) ratio than previous and current smokers (P < 0.001). The FEV1 /FVC ratio declined faster in current smokers than in never smokers (P = 0.05) or ex-smokers (P = 0.01). The baseline modified Rodnan skin thickness score (MRSS) and the MRSS decline were comparable across smoking groups. Although heavy smoking (>25 pack-years) increased the odds of digital ulcers by almost 50%, there was no robust adverse association of smoking with digital ulcer development. CONCLUSION: The known adverse effect of smoking on bronchial airways and alveoli is also observed in SSc patients; however, robust adverse effects of smoking on the progression of SSc-specific pulmonary or cutaneous manifestations were not observed.
The ARCO study (Study on Adherence of Rheumatoid Arthritis patients to SubCutaneous and Oral Drugs), a multicenter, non-interventional retrospective study, was primarily designed to assess the percentage of patients [aged ≥18 years with an established rheumatoid arthritis (RA) diagnosis] with non-adherence to prescribed subcutaneous biologicals. This paper reports data for the secondary objective from a subset of patients, namely to evaluate non-adherence to prescribed oral antirheumatic drugs in RA patients in Spain using the validated Compliance Questionnaire Rheumatology (CQR). Patients also completed the Morisky-Green Medication Adherence Questionnaire, Beliefs about Medicines Questionnaire, and a questionnaire (developed and validated in Spain) on patient satisfaction with RA treatment and preferences. A total of 271 patients (76.7% females; mean age 55.6 years) were being treated with oral drugs for RA, of which 234 completed the CQR questionnaire. Non-adherence was reported in 49/234 (20.9%) patients. The proportion of non-adherence in younger patients (aged ≤48 years; 37.5%) was double that recorded in patients aged >48 years (p = 0.006). Patients with a perception of lower efficacy also had a higher risk of non-adherence (p = 0.012). Multivariable analysis showed that younger age and male gender were independently associated with risk of non-adherence. There was only slight agreement between the CQR and Morisky-Green assessment tools (kappa coefficient = 0.186), possibly reflecting the fact that both questionnaires measure slightly different aspects of medication adherence. In conclusion, one out of five RA patients was identified as at risk for non-adherence with the CQR, and this was more frequent in younger patients and in males.
AssuntosAntirreumáticos/administração & dosagem , Artrite Reumatoide/tratamento farmacológico , Adesão à Medicação , Inquéritos e Questionários , Administração Oral , Adulto , Idoso , Antirreumáticos/efeitos adversos , Artrite Reumatoide/diagnóstico , Artrite Reumatoide/psicologia , Distribuição de Qui-Quadrado , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Estudos Retrospectivos , Fatores de Risco , Espanha , Resultado do Tratamento
A genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA. Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2). In the present study, we assessed the potential association of these polymorphisms with CVD in Southern European RA patients. We also assessed if polymorphisms implicated in the increased risk of subclinical atherosclerosis in non-rheumatic Caucasians (ZHX2, PINX1, SLC17A4, LRIG1 and LDLR) may influence the risk for CVD in RA. 2,609 Spanish patients were genotyped by TaqMan assays. Subclinical atherosclerosis was determined in 1,258 of them by carotid ultrasonography (assessment of carotid intima media thickness and presence/absence of carotid plaques). No statistically significant differences were found when each polymorphism was assessed according to the presence/absence of cardiovascular events and subclinical atherosclerosis, after adjustment for potential confounder factors. Our results do not show an association between these 15 polymorphisms and atherosclerosis in RA.
AssuntosArtrite Reumatoide/genética , Aterosclerose/complicações , Aterosclerose/genética , Doença da Artéria Coronariana/complicações , Doença da Artéria Coronariana/genética , Predisposição Genética para Doença , Polimorfismo de Nucleotídeo Único/genética , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Espanha
Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA.
AssuntosArtrite Reumatoide/sangue , Artrite Reumatoide/genética , Aterosclerose/sangue , Aterosclerose/genética , Proteína C-Reativa/genética , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/genética , Idoso , Artrite Reumatoide/epidemiologia , Aterosclerose/diagnóstico por imagem , Aterosclerose/epidemiologia , Doenças Cardiovasculares/diagnóstico por imagem , Doenças Cardiovasculares/epidemiologia , Grupo com Ancestrais do Continente Europeu , Feminino , Predisposição Genética para Doença , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo Genético , Fatores de Risco
OBJECTIVE: Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc-RA genetic loci have been identified independently. The aim of the current study was to systematically search for new common SSc-RA loci through an interdisease meta-genome-wide association (meta-GWAS) strategy. METHODS: The study was designed as a meta-analysis combining GWAS data sets of patients with SSc and patients with RA, using a strategy that allowed identification of loci with both same-direction and opposite-direction allelic effects. The top single-nucleotide polymorphisms were followed up in independent SSc and RA case-control cohorts. This allowed an increase in the sample size to a total of 8,830 patients with SSc, 16,870 patients with RA, and 43,393 healthy controls. RESULTS: This cross-disease meta-analysis of the GWAS data sets identified several loci with nominal association signals (P < 5 × 10(-6) ) that also showed evidence of association in the disease-specific GWAS scans. These loci included several genomic regions not previously reported as shared loci, as well as several risk factors that were previously found to be associated with both diseases. Follow-up analyses of the putatively new SSc-RA loci identified IRF4 as a shared risk factor for these 2 diseases (Pcombined = 3.29 × 10(-12) ). Analysis of the biologic relevance of the known SSc-RA shared loci identified the type I interferon and interleukin-12 signaling pathways as the main common etiologic factors. CONCLUSION: This study identified a novel shared locus, IRF4, for the risk of SSc and RA, and highlighted the usefulness of a cross-disease GWAS meta-analysis strategy in the identification of common risk loci.
AssuntosArtrite Reumatoide/genética , Estudo de Associação Genômica Ampla , Fatores Reguladores de Interferon/genética , Escleroderma Sistêmico/genética , Loci Gênicos , Predisposição Genética para Doença , Humanos , Fatores de Risco
The aim of the study was to profile those patients included in the RELESSER registry with histologically proven renal involvement in order to better understand the current state of lupus nephritis (LN) in Spain. RELESSER-TRANS is a multicenter cross-sectional registry with an analytical component. Information was collected from the medical records of patients with systemic lupus erythematosus who were followed at participating rheumatology units. A total of 359 variables including demographic data, clinical manifestations, disease activity, severity, comorbidities, LN outcome, treatments, and mortality were recorded. Only patients with a histological confirmation of LN were included. We performed a descriptive analysis, chi-square or Student's t tests according to the type of variable and its relationship with LN. Odds ratio and confidence intervals were calculated by using simple logistic regression. LN was histologically confirmed in 1092/3575 patients (30.5%). Most patients were female (85.7%), Caucasian (90.2%), and the mean age at LN diagnosis was 28.4â±â12.7 years. The risk for LN development was higher in men (M/F:47.85/30.91%, Pâ<â0.001), in younger individuals (Pâ<â0.001), and in Hispanics (Pâ=â0.03). Complete response to treatment was achieved in 68.3% of patients; 10.35% developed ESRD, which required a kidney transplant in 45% of such cases. The older the patient, the greater was the likelihood of complete response (Pâ<â0.001). Recurrences were associated with persistent lupus activity at the time of the last visit (Pâ<â0.001) and with ESRD (Pâ<â0.001). Thrombotic microangiopathy was a risk factor for ESRD (Pâ=â0.04), as for the necessity of dialysis (Pâ=â0.01) or renal transplantation (Pâ=â0.03). LN itself was a poor prognostic risk factor of mortality (OR 2.4 [1.81-3.22], Pâ<â0.001). Patients receiving antimalarials had a significantly lower risk of developing LN (Pâ<â0.001) and ESRD (Pâ<â0.001), and responded better to specific treatments for LN (Pâ=â0.014). More than two-thirds of the patients with LN from a wide European cohort achieved a complete response to treatment. The presence of positive anti-Sm antibodies was associated with a higher frequency of LN and a decreased rate of complete response to treatment. The use of antimalarials reduced both the risk of developing renal disease and its severity, and contributed to attaining a complete renal response.
AssuntosNefrite Lúpica/epidemiologia , Sistema de Registros , Adolescente , Adulto , Feminino , Humanos , Nefrite Lúpica/terapia , Masculino , Recidiva , Estudos Retrospectivos , Reumatologia , Espanha/epidemiologia , Adulto Jovem
OBJECTIVES: To determine whether the interleukin-33 (IL-33)-interleukin-1 receptor like 1 (IL-1RL1) signaling pathway is implicated in the risk of subclinical atherosclerosis in patients with rheumatoid arthritis (RA). METHODS: A total of 576 Spanish RA patients from Northern Spain were genotyped for 6 well-known IL33-IL1RL1 polymorphisms (IL33 rs3939286, IL33 rs7025417, IL33 rs7044343, IL1RL1 rs2058660, IL1RL1 rs2310173 and IL1RL1 rs13015714) by TaqMan genotyping assay. The presence of subclinical atherosclerosis was determined by the assessment of carotid intima-media thickness (cIMT) by carotid ultrasound (US). RESULTS: RA patients carrying the TT genotype of the IL33 rs3939286 polymorphism had lower cIMT values than those homozygous for the CC genotype (mean ± standard deviation (SD): 0.71 ± 0.14 mm versus 0.76 ± 0.16 mm, respectively) while patients carrying the CT genotype had intermediate cIMT values (mean ± SD: 0.73 ± 0.17 mm). Moreover, RA patients carrying the mutant allele T of the IL33 rs3939286 polymorphism exhibited significantly lower cIMT values than those carrying the wild allele C (mean ± SD: 0.72 ± 0.16 mm versus 0.75 ± 0.18 mm respectively; p = 0.04). The association of both genotype and allele frequencies of IL33 rs3939286 and cIMT levels remained statistically significant after adjustment for sex, age at the time of US study, follow-up and center (p = 0.006 and p = 0.0023, respectively), evidencing that the potential effect conferred by IL33 rs3939286 may be independent of confounder factors. No association with other IL33-IL1RL1 genetic variants was observed. CONCLUSIONS: In conclusion, our results may suggest a potential protective effect of the IL33 rs3939286 allele T in the risk of subclinical atherosclerosis in patients with RA.
AssuntosArtrite Reumatoide/genética , Aterosclerose/genética , Interleucina-33/genética , Adulto , Idoso , Alelos , Artrite Reumatoide/complicações , Aterosclerose/etiologia , Artérias Carótidas/diagnóstico por imagem , Feminino , Seguimentos , Frequência do Gene , Genótipo , Humanos , Desequilíbrio de Ligação , Masculino , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único , Receptores Tipo I de Interleucina-1/genética , Risco , Ultrassonografia
INTRODUCTION: We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tumor necrosis factor (anti-TNF) antibodies in the treatment of rheumatoid arthritis (RA). METHODS: The G1m genotypes were analyzed in three collections of patients with RA totaling 1037 subjects. The first, used for discovery, comprised 215 Spanish patients. The second and third were successively used for replication. They included 429 British and Greek patients and 393 Spanish and British patients, respectively. Two outcomes were considered: change in the Disease Activity Score in 28 joint (ΔDAS28) and the European League Against Rheumatism (EULAR) response criteria. RESULTS: An association between less response to INX and incompatibility of the G1m1,17 allotype was found in the discovery collection at 6 months of treatment (P = 0.03). This association was confirmed in the replications (P = 0.02 and 0.08, respectively) leading to a global association (P = 0.001) that involved a mean difference in ΔDAS28 of 0.4 units between compatible and incompatible patients (2.3 ± 1.5 in compatible patients vs. 1.9 ± 1.5 in incompatible patients) and an increase in responders and decrease in non-responders according to the EULAR criteria (P = 0.03). A similar association was suggested for patients treated with ADM in the discovery collection, but it was not supported by replication. CONCLUSIONS: Our results suggest that G1m1,17 allotypes are associated with response to INX and could aid improved therapeutic targeting in RA.
AssuntosAdalimumab/genética , Artrite Reumatoide/tratamento farmacológico , Artrite Reumatoide/genética , Imunoglobulina G/genética , Infliximab/genética , Adalimumab/uso terapêutico , Adulto , Antirreumáticos/uso terapêutico , Artrite Reumatoide/imunologia , Sequência de Bases , Feminino , Genótipo , Humanos , Alótipos de Imunoglobulina , Infliximab/uso terapêutico , Masculino , Pessoa de Meia-Idade , Dados de Sequência Molecular , Polimorfismo de Nucleotídeo Único , Resultado do Tratamento , Fator de Necrose Tumoral alfa/antagonistas & inibidores
BACKGROUND: The IL-6 -174G/C genetic variant has recently been associated with the clinical response to etanercept therapy in rheumatoid arthritis (RA) patients. Considering previous results, the aim of our study was to validate the role of this polymorphism as a predictor of the antitumor necrosis factor (anti-TNF) treatment outcome in RA. MATERIALS AND METHODS: Our study population was composed of 199 Spanish patients with RA receiving anti-TNF therapy. The IL-6 -174G/C (rs1800795) genetic variant was genotyped using the TaqMan allelic discrimination technology. Patients were classified, according to the European League Against Rheumatism (EULAR) criteria, as responders (good and moderate response) and nonresponders at 6, 12, 18, and 24 months after the first infusion. RESULTS: The -174*G allele was significantly associated with a good or moderate EULAR response at 12 [P=0.015, odds ratio (OR)=2.93, 95% confidence interval (CI) 1.29-6.70], 18 (P=4.54E-03, OR=5.17, 95% CI 1.80-14.85), and 24 months (P=4.54E-03, OR=14.86, 95% CI 2.91-75.91). A meta-analysis combining these data with the results from a previous study confirmed this association (P=1.89E-02, OR=1.80, 95% CI 1.13-2.87, at 12 months). CONCLUSION: Our results support the role of the -174G/C IL-6 polymorphism as a genetic marker of responsiveness to anti-TNF therapy.


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- Rajasthan, India
Bilara is a city and a municipality in Jodhpur district in the state of Rajasthan, India. Bilara is a Persian word derived from bilor which is the name of a diamond. It is also used in Urdu and Punjabi languages for 'something which is extremely glittery'.
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Private snorkeling boat trip to Coral Island from Phuket
Activity: Snorkeling
Languages spoken: English, French
Duration: 8 hrs
Difficulty: Easy
1x 507 €
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Category: Worship
A Festival of Lessons and Carols
Angels I have known
Today we celebrate the legacy of St. Francis. We've probably all heard stories about him – making you believe he was, perhaps, a little crazy – but he was a good man and loved to share the Good News of the Gospel.
One story tells of an encounter with a flock of birds – doves, crows – all sorts of birds. When St. Francis spotted them down the road, he ran toward them and expected them to scatter but to his surprise – and probably anyone else's who may have witnessed this – the birds stood still and seemed to wait for him. He was filled with awe and he asked them to stay and then proceeded to give them a little sermon, reminding them that they should always praise their Creator for he was the one who gave them feathers for clothes, wings to fly, and anything else that was needed. "It is God who made you noble among all creatures, making your home in thin, pure air. Without sowing or reaping, you received God's guidance and protection." And so the story goes that from that day on, Francis made it his habit to invoke all animals to praise and love their Creator.
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Click here to read the whole sermon preached by Susan Mitchell on Pet Blessing Sunday, 2019
Pet Blessing
Purses, Aprons, and Politics
sermon on Luke 12:32-40
The Rev. Kara Wagner Sherer
I have a large cardboard box in my basement, filled with hardly used, basically new purses, wallets, backpacks and bags. They were once THE thing my daughters had to have to hold their wallets, laptops etc. but a second after they were purchased they were out of style, hence the large box of purses in my basement.
When I read the parable today I thought, "Great!" I don't have to prepare a sermon this week, I can just bring that box to church and give everyone an almost new purse and tell you "Jesus said, sell all your things, give the money away. Make for yourself purses that do not wear out, treasures in heaven!"
I think I am in a cleaning mode because of this week's news. Those of you who were alive on 9/11 will never forget where you were. I haven't. It was the month we moved into a new apartment, before I started seminary. I was cleaning. And when I heard the news I just kept cleaning. Listening to the radio and cleaning. It is what I do when I am under stress, paralyzed by the world.
So I've called you here today to ask, "What should we do?"
Should we raise money and send all the lawyers at St. John's to the border and to Mississippi? Should we gather the doctors, nurses and counselors that we know to go Dayton and El Paso and the streets of Chicago? Should we get all our writers and artists and musicians to Washington, DC to write new protest songs, bang on drums, make signs and not be silent until our elected officials do their jobs? And who will stay home to help Mark plan his mother's funeral, and mourn with our neighbor whose husband's funeral is next week? Who will take care of the kids and make dinner?
Suddenly the side door opens (the one by the organ that no one ever uses) and a stranger walks in. We've never seen him before, but we know exactly who he is. He looks at me and says, "Kara, sit down!" and at all of us and says, "Stop, breathe, hold on."
"But Jesus! What should we do? Should we go to the border? To Mississippi and Dayton and El Paso. What about our own Chicago neighborhoods? And who will watch the kids?"
Jesus doesn't answer. He goes downstairs. He puts on an apron, not one of the white ones, but that one from Nicaragua with all the embroidery on it. And he rummages in the fridge. And suddenly we are all eating. Nothing fancy, but good food, lots of fruit and vegetables, home-made, nothing processed…real comfort food. And Jesus serves the food and picks up the dishes. And washes them. And Jesus says "Stop, breathe, eat, enjoy each other's company. You have everything you need. You are ready."
"Now go and do what I have called you to do."
Sermon preached on Sunday, August 11, 2019. For more sermons go to:
Gospel on the Green
Holy Week and Easter
Palm Sunday April 14, 8:00 and 10:00 a.m.
Weather permitting the 8:00 a.m. service begins outside the Byron Street door.
The 10:00 a.m. parade begins in the garden. The service will continue in the sanctuary at about 10:30 a.m.
Children's Holy Week Wednesday, April 17, 5:30 p.m.
Experience all the stories of Holy Week, includes a simple meal.
Maundy Thursday April 18, 7:30 p.m.
Celebration of the first Eucharist, with the rite of footwashing.
Good Friday April 19, 12:00 and 7:30 p.m.
The Liturgy of the Passion
The Great Vigil of Easter Saturday, April 20, 7:30 p.m.
The lighting of the new fire, the first proclamation of Easter!
Easter Sunday, April 21, 8:00, 9:30 and 11:00 a.m.
The day of Alleluias! An Easter Egg Hunt follows each service.
Sunday Worship
Save a tree! You can download this pdf of our Sunday bulletins and follow along on your phone or tablet.
We invite you into our faith community!
The Twelve Days of Christmas!
Friday, December 28 at 7:00 p.m. Cocktails with Connie and Maureen (email them for address) Adults only!
Sunday, December 30 at 9:00 a.m. Pancake breakfast. Wear your pj's to church at 8:00 or 10:00 a.m.!
Sunday, December 30 at approximately 3:00 p.m. Afternoon at the movies to see Mary Poppins Returns. Please sign up in the Parish Hall so we can get reduced group tickets. Contact organizer Mark.
Tuesday, January 1, 2019, Sunrise at Montrose Harbor. Meet Sue, Tom, Connie, and Maureen just past the bird sanctuary at Montrose Harbor. Watch the sunrise and then go out for breakfast.
Thursday, January 3, from 7:00–9:00 p.m. Game Night with the Singer Bradley Family (email them for address).
Friday, January 4 at 12:00 p.m. Ice Skating. Meet at St. John's to carpool to the Wrigley Skating Rink; return
at 2:00 p.m. for hot chocolate.
Sunday, January 6, at 8:00, 9:15 and 11:00 a.m. DIY pageant. Sign up in the Parish Hall to help with directing, staging and costumes (optional!).


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Impact of Diabetes on the Body Essay
Impact of Diabetes on the Body Essay
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According to the Centers for Disease Control and Prevention, "25.8 million people, or 8.3% of the U.S. population, have diabetes". Many Americans in the US have what is called uncontrolled diabetes, meaning where you don't take of yourself with diabetes. This can cause you many different complications, including such as the Eyes, Stroke, Kidneys, Feet, HHSN, and Ketoacidosis. These are very serious and sometimes deadly. With daily exercise, healthy eating, and of course maintaining your diabetes you will live a healthy future.
To start with, what is and how do you get diabetes? Diabetes is where your pancreas is unable to make insulin, when that happens your blood glucose fluctuates. There are two types of diabetes, type 1, and type 2. The American Diabetes Association states that, "In type 1 diabetes, the body does not produce insulin. Insulin is a hormone that is needed to convert sugar, starches and other food into energy needed for daily life. With the help of insulin therapy and other treatments, even young children can learn to manage their condition and live long, healthy lives". Then the other type of diabetes, is type 2. Type 2 Diabetes is where your body and pancreas doesn't properly make or use the insulin. In the beginning your pancreas makes a big amount of insulin, then cant keep up the to the amount of insulin being made, and eventually cant make enough to where your glucose levels are at a proper amount. Type 1 diabetes in inherited from your own ancestry and is unpreventable. Type 2 diabetes is caused by eating unhealthy, and becoming obese. Type 2 diabetes is very preventable by eating a healthy diet and exercising regularly.
If you have uncontrolled diabetes and your unwilling to take care of it, you wi...
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Garber , Alan. Prevalence of Diabetes-related CV Disease. unknown. Photograph.
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Reynolds, Chelsea. "Why Good Foot Care Is Important for Diabetes." Diabetic Living .
n.d. Unknown. Web Magazine. 20 Feb. 2014.
Common Foot Problems. 2013. Photograph. www.fowardarch.com, Carlsbad, CA. Web.
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Gulledge, Jo, and Shawn Beard. Diabetes Management: Clinical Pathways, Guidelines,
and Patient Education. Jones & Bartlett Learning, 1999. 301-117. eBook.
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"Their Religious Devotion and Tenacious Irish Spirit": President Trump Proclaims Irish-America Heritage Month
News Staff : Mar 16, 2018 Whitehouse.gov
"My grandfather was very typical of the millions that would come to these shores. He embodied all that's best about the Irish—sturdy work ethic, faith in God, love of family, patriotism. And those are the enduring contributions of people of Irish descent in the history of this country." -Vice President Mike Pence
(Washington, DC)—[Whitehouse.gov] Ireland's Taoiseach (pronounced TEE-shuck)—the country's term for its prime minister and head of government—is visiting President Donald J. Trump at the White House for St. Patrick's Day. Leo Varadkar, who has served as Taoiseach since last June, continues a long tradition of visits from the Irish prime minister to the United States to mark the international Irish holiday. (Photo: President Trump and Ireland's PM Leo Varadkar/White House Photo/WhiteHouse.gov)
In 1952, Ireland's ambassador to Washington kicked off what became an annual custom by sending President Harry Truman a box of shamrocks. Four years later, the first St. Patrick's Day meeting between an American President and the Irish Taoiseach took place at the White House.
By the 1990s, a St. Patrick's Day visit from the leader of Ireland had become an annual tradition.
The Taoiseach's visit offers a moment to reflect on the importance of the Irish people and their descendants to American history. To that end, President Trump declared March 2018 as Irish-American Heritage Month. "For centuries, the tenacious Irish spirit, paired with American self-reliance, has helped Irish immigrants and their descendants realize incredible dreams," the President wrote. "With religious devotion, strength rooted in the love of family, and confidence in the promise of America, Irish Americans have engaged in the American experience in robust and meaningful ways."
These contributions date back to our Nation's beginning. At least eight signers of the Declaration of Independence, including four of the Founding Fathers, had Irish roots.
Presidents Andrew Jackson, John F. Kennedy, and Ronald Reagan all traced their ancestry back to Ireland. Today, no fewer than 33 million Americans claim Irish origins, including Vice President Mike Pence.
"My grandfather was very typical of the millions that would come to these shores. He embodied all that's best about the Irish—sturdy work ethic, faith in God, love of family, patriotism," the Vice President said. "And those are the enduring contributions of people of Irish descent in the history of this country."
During his visit, Taoiseach Varadkar plans to promote Ireland and Irish businesses, as well as continue to deepen his country's connection to its American ally.
"As we spend this month honoring Irish Americans, we also pledge to further strengthen our relationship with the Emerald Isle itself," President Trump wrote in this month's Proclamation. "We look forward to a bright future of greater friendship, cooperation, and commerce for centuries to come."
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What are environmental regulations on mining activities ...
Government-approved permits are required for all new and ongoing mining operations, including exploration activities. This permitting process ensures that environmental standards are maintained from the beginning to the end of mining and metal production operations.
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Sep 22, 2019· Also, the same thing for ships who are towing and droping the whole asteroid. For now in the Starbase - asteroid mining we can only see how the asteroid is just Disappearing. Also, it will be nice to have much more diverse ore and mineral reprocessing machinery (especialy for …
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India - Mining & Mineral Processing Equipment | export.gov
The most attractive niche sector for U.S. exports is high-end, specialized coal mining equipment. India allows 100 percent foreign direct investment (FDI) in mining and exploration of non-core minerals like gold, silver, and diamonds, as well as in oil exploration and captive mining of coal and lignite and in coal processing (washing and sizing).
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Outlining best practices in gold processing from a variety of perspectives, Gold Ore Processing: Project Development and Operations is a must-have reference for anyone working in the gold industry, including metallurgists, geologists, chemists, mining engineers, and many others.
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