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Tent Trail 5 Persons Camping SUV Hiking Family Shelter Outdoor Canopy Easy Setup— November 5, 2019
Ozark Trail 5-Person Camping SUV Tent. This 5-Person Camping SUV Tent is an excellent choice for first time campers, year-round camping, family outings, group events, picnics, or music festivals. Is this tent easy to set up? From your backyard to local camp grounds, state and national parks, this 5-Person Camping SUV Tent is fast and easy to set up for any outdoor adventure. This 5-Person Camping SUV Tent offers added headroom for a more comfortable experience and can sleep up to five adult campers. Will this tent keep you dry? This 5-Person Camping SUV Tent features a seam-taped rainfly for superior weather protection to keep campers dry and protected in all weather. The roll-back rainfly allows users the ability to keep cool on hot summer nights. This 5-Person SUV Tent comes with a hanging media sleeve that supports most tablet sizes and power port to run an electric cord into the tent for power needs. The Ozark Trail 5-Person Camping SUV Tent also features a mud mat to help keep the interior of the tent clean. The Ozark Trail 5-Person Camping SUV Tent is a perfect choice for camping, backpacking, family outings, group events, picnics, or music festivals. Easy to set up in minutes. Free standing dome tent can be attached to SUV/Mini Van. Offers two entries if not attached to SUV. For fun beginners and experienced campers. Kids will love the space. Good for Families, groups, adults and kids outings. Removable rainfly for better ventilation. Vestibule offers added protection from wind and rain. Features a media pocket and multiple storage pockets. Attached Mud Mat helps keep interior clean. Spacious interior for 5 people. Frame: Fiber glass poles. If ordering electrical items outside of the U. Please note that they will come equipped with a standard U. You will need a suitable adapter to use the item in your country. An adult signature will be required. Please be sure to have available help on hand to assist you with moving the item to the desired location in or outside of your home. The item "Tent Trail 5 Persons Camping SUV Hiking Family Shelter Outdoor Canopy Easy Setup" is in sale since Tuesday, October 1, 2019. This item is in the category "Sporting Goods\Outdoor Sports\Camping & Hiking\Tents & Canopies\Tents". The seller is "mega-intl" and is located in Beverly Hills, California. This item can be shipped to United States, Canada, United Kingdom, Denmark, Romania, Slovakia, Bulgaria, Czech republic, Finland, Hungary, Latvia, Lithuania, Malta, Estonia, Australia, Greece, Portugal, Cyprus, Slovenia, Japan, China, Sweden, South Korea, Indonesia, Taiwan, South africa, Thailand, Belgium, France, Hong Kong, Ireland, Netherlands, Poland, Spain, Italy, Germany, Austria, Bahamas, Mexico, New Zealand, Philippines, Singapore, Switzerland, Norway, Ukraine, Croatia, Malaysia, Brazil, Chile, Colombia, Costa rica, Dominican republic, Panama, Trinidad and tobago, Guatemala, El salvador, Honduras, Jamaica, Antigua and barbuda, Aruba, Dominica, Grenada, Saint lucia, Barbados, Bermuda, Brunei darussalam, Bolivia, French guiana, Gibraltar, Iceland, Cambodia, Luxembourg, Martinique, Maldives, Nicaragua, Peru, Pakistan, Paraguay, Viet nam, Uruguay, Russian federation.
- Model: WT180909
- Style: SUV Tent
- Material: Polyester
- Type: Sleeping Unit
- Capacity: 5 Person
- Features: Organizer Pockets
- Color: Blue/White
- Brand: Ozark Trail


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Fly inside Uber's new air taxi cabin
Tuesday 11 June 2019 20:44 CEST
Here's what Uber Air's in-flight customer experience will look like. The company plans to offer aerial ridesharing in 2023.
Start a season-long league with your friends. Play for a share of $1,000,000. Get a free entry into the NFL Sunday Million with your first deposit. Payable Action: Deposit (Minimum $10) Restrictions: No incent. State restricted (see offer targeting).
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subset: commoncrawl


text: GlobeNewswire: TV One, LLC Contains the last 10 of 5 releaseshttp://www.globenewswire.com/External?Length=42019-12-06T22:13:04ZGlobeNewswirehttp://firstname.lastname@example.com (NewsDesk)http://www.globenewswire.com/news-release/2015/11/08/784912/10155631/en/Tomorrow-s-TV-One-s-News-One-Now-Devoted-to-Coverage-of-Hillary-Clinton-s-South-Carolina-Town-Hall-Meeting.html?f=22&fvtc=4&fvtv=26664Tomorrow's TV One's "News One Now" Devoted to Coverage of Hillary Clinton's South Carolina Town Hall Meeting2015-11-08T15:05:18Z<![CDATA[Former Secretary of State Addresses Issues Important to African American Community WASHINGTON, Nov. 8, 2015 (GLOBE NEWSWIRE) -- ]]>http://www.globenewswire.com/news-release/2015/11/06/784866/10155609/en/TV-One-s-News-One-Now-Announces-Live-Streaming-of-Hillary-Clinton-s-South-Carolina-Town-Hall-Meeting-in-Addition-to-Monday-s-Show-Coverage.html?f=22&fvtc=4&fvtv=26664TV One's News One Now Announces Live Streaming of Hillary Clinton's South Carolina Town Hall Meeting in Addition to Monday's Show Coverage2015-11-06T22:35:06Z<![CDATA[Host Roland S. Martin to Serve as Moderator of Claflin University Event WASHINGTON, Nov. 6, 2015 (GLOBE NEWSWIRE) -- TV One's News One Now, the first morning news program in history to focus on news and analysis of politics, entertainment, sports, and culture from an explicitly African American perspective, will live stream Presidential Democratic Candidate Hillary Clinton's Orangeburg, South Carolina Town Hall Meeting via TV One and News One Now's companion websites www.TVOne.tv and www.NewsOne.com. The live streaming will begin at 1:15 p.m. ET on Saturday, Nov. 7.]]>http://www.globenewswire.com/news-release/2015/08/19/761840/10146547/en/TV-One-Partners-with-National-Action-Network-NAN-and-Reverend-Al-Sharpton-to-Premiere-First-Ever-Television-Airing-of-The-Triumph-Awards.html?f=22&fvtc=4&fvtv=26664TV One Partners with National Action Network (NAN) and Reverend Al Sharpton to Premiere First-Ever Television Airing of The Triumph Awards2015-08-19T15:37:05Z<![CDATA[Wanda Sykes, Tyrese Gibson and Rosalind Hudnell among Honorees SILVER SPRING, Md., Aug. 19, 2015 (GLOBE NEWSWIRE) -- TV One, the National Action Network (NAN) and Reverend Al Sharpton, are partnering to present the first televised airing of The Triumph Awards. ]]>otherlogoNANlogohttp://www.globenewswire.com/news-release/2015/08/16/760939/10146176/en/TV-One-s-News-One-Now-Devotes-Entire-Show-to-Passing-of-Civil-Rights-Leader-Julian-Bond.html?f=22&fvtc=4&fvtv=26664TV One's News One Now Devotes Entire Show to Passing of Civil Rights Leader Julian Bond2015-08-16T23:10:08Z<![CDATA[National Civil Rights Leaders Join Managing Editor and Host Roland S. Martin In Celebration and Tribute to Icon's Life WASHINGTON, Aug. 16, 2015 (GLOBE NEWSWIRE) -- TV One's New One Now, the only daily news program targeting Black viewers, is dedicating its entire show on Monday, Aug. 17 (9-10 a.m. ET), to the passing of civil rights activist and leader Julian Bond. Chairman Emeritus and a former Chairman of the National Association for the Advancement of Colored People, Bond passed away at the age of 75 on Aug. 15 in Fort Walton Beach, Florida. NAACP executive leaders Cornell Brooks, President and CEO, and Roslyn Brock, Chairman of the National Board of Directors; National Urban League President and Chief Executive Officer Marc. H. Morial; Founder and President of the Rainbow PUSH Coalition Rev. Jesse L. Jackson, Sr.; and Charles E. Cobb, Jr., professor and former activist with the Student Nonviolent Coordinating Committee; will join News One Now host and managing editor Roland S. Martin to celebrate and pay tribute to Bond's life's work and contributions to the Civil Rights Movement. Additional guests, including newsmakers, politicians and experts, will join the program.]]>http://www.globenewswire.com/news-release/2015/07/23/754611/10142903/en/TV-ONE-AND-AT-T-U-VERSE-EXTEND-AGREEMENT-FOR-11-MORE-YEARS.html?f=22&fvtc=4&fvtv=26664TV ONE AND AT&T U-VERSE EXTEND AGREEMENT FOR 11 MORE YEARS2015-07-23T14:31:59Z<![CDATA[TV One, a trusted storyteller with such signature series as "Unsung," has established itself as voice of Black culture SILVER SPRING, Md., July 23, 2015 (GLOBE NEWSWIRE) -- TV One and AT&T U-verse today extended their agreement into 2026.]]>


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All are invited to Frank Lloyd's Wright Martin House for Tree of Light, a free event open to the public.
Enjoy holiday crafts, kids' story time, holiday treats, and a NYS Parks snowshoe display. Or simply enjoy the Martin House plaza while listening to festive holiday music provided by Buffalo Girlchoir.
The Martin House will be open for walk throughs, and the Museum Store will be open, offering the perfect gift for every person on your list.
At 5 pm, we will light the 22' tree for the first time!
Thank you to our generous sponsors, including event sponsor Northwest Bank.
No need to RSVP for this fun event. Grab your friends and family, and join us.
Northwest Bank
Suzanne Badgley
We make every effort to ensure the accuracy of this information. However, you should always call ahead to confirm dates, times, location, and other information.


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Big Girl Clothes (7-16)
Find the most stylish clothing for your girl at Sophia's Style! She's at the perfect age for shopping with mom, and you can do it right from home with our fabulous boutique website! Help her develop her style by putting together outfits with her, because everything you need to make a complete ensemble is right here on our webpage. We carry all the greatest brands of girls clothing, and you can get it at discount prices! She'll be the best dressed girl at school with unique and gorgeous clothes
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Amberry Girls Multi Color Organza 3D Flower Girl Dress 2T-14$35.99 Retail Price: $54.00
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Ellie Kids Girls Multi Color Lace Sleeveless Rhinestones Christmas Dress 4-14$39.99 Retail Price: $60.00
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Copyright ©2011, D.R. Horton Insurance Agency, Inc. All Rights Reserved. These materials may not be copied for commercial use or distribution and may not be framed or posted on other sites. Coverage and credits may not be available at all locations or to all customers. This is to give notice that D.R. HORTON, INC., and its subsidiaries have a business relationship with D.R. HORTON INSURANCE AGENCY. The nature of this business relationship is that D.R HORTON INSURANCE AGENCY is directly or indirectly owned by the parent corporation D.R. HORTON, INC. Because of this relationship D.R. HORTON, INC. may receive financial or other benefit from your business. D.R. Horton Insurance Agency is a wholly owned subsidiary and affiliate of D.R. Horton, Inc. This site is governed by the Terms and Conditions & Privacy Policy of D.R. Horton, Inc. D.R. Horton Insurance Agency is licensed and will quote only in Alabama, Arizona, Arkansas, California, Colorado, Delaware, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Louisiana, Maryland, Minnesota, Mississippi, Nevada, New Jersey, New Mexico, New York, North Carolina, Oklahoma, Oregon, Pennsylvania, South Carolina, Texas, Utah, Virginia, Washington, West Virginia and Wisconsin. Any information provided is only applicable to residents in those states. This web site and its contents are not to be considered a solicitation of insurance in any state other than those states in which the agency is licensed.
Jonathan Longnecker and Greg Gerber both experienced mechanical issues with their brand new RVs, requiring frequent repairs. As a result, both bloggers suggest buying used or vintage RVs and renovating them, learning your machine's ins and outs during the process. This way, owners can take care of repairs themselves instead of losing travel time waiting for overbooked RV service shops under their insurance policy.
In the states with no-fault insurance, insured drivers are typically paid for medical expenses by their own insurers, regardless of who caused the accident. Nonetheless, BI liability coverage is still required in no-fault states because if injuries are bad, the at-fault driver may be sued by the injured party. If that happens, your BI coverage can help cover your liability expenses.
The key difference in collision vs. comprehensive coverage is that, to a certain extent, the element of the car driver's control. As we have stated before, collision insurance will typically cover events within a motorist's control, or when another vehicle collides with your car. Comprehensive coverage generally falls under "acts of God or nature," that are typically out of your control when driving. These can include such events as a spooked deer, a heavy hailstorm, or a carjacking.
Further examples are the company's storage option and low mileage discount—both great solutions for part-time RVers. Baby Boomers are more likely to own a home and those that were born between 1946 and 1964 are now heading into retirement. This makes them more prone to RV part-time rather than full-time when compared to Millennials, for example. Some Baby Boomers end up making their RVs a home-on-wheels, but many are also likely to take their RV out for vacation with their families, or to explore the great outdoors for certain seasons or periods of time.
Whether you are a Millennial or a Baby Boomer, if you have never traversed the tricky field of buying insurance for an RV, your best option is most likely going to be a reliable marketplace that can both inform and point users in the right direction. RVInsurance.com is just that kind of marketplace, featuring a wealth of helpful information pertaining to purchasing an RV, insuring it, and staying safe on the road.
Do you live in your RV full-time, or does it sit in storage for most of the year? Do you have any permanent attachments like a satellite dish? Every company offers basic RV coverage, but the right provider for you also offers the set of add-ons that speaks to your main concerns, whether it's full-time residency insurance or roadside assistance. Our top picks all have plenty of add-ons in addition to basic coverage.
We evaluated each company's track record with its customers by looking at the available complaint data on online regulatory organizations' pages and by searching for company pages on independent consumer review websites such as the Better Business Bureau. Some companies also provide unfiltered reviews on their own websites, helping to give greater insight into customer satisfaction rates.


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Wix offers a free plan if you don't mind having your site address structured http://yourwebsite.wix.com/yourwebsite. Their only caps are around file storage and features – not around pages or page types. Their paid plans aren't outstanding (they are actually a disadvantage listed here shortly), but they are competitive enough for short-term projects.
As a free trial member, if you wish to promote Wealthy Affiliate, you will get a commission that is 50% lesser than premium members. For example, free trial members earn $4 and premium members earn $8 on the first month subscription, $11.75/mth of commission for recurring payments for free trial members and $23.50/mth for premium members. I hope this clarifies.
The primary purpose of any review, including this review of Wealthy Affiliate, is to help you decide if you should or should not sign up or purchase something. For starters, since you can sign up for a free account at Wealthy Affiliate, I think that is a no-brainer way to go. Don't take my word or anyone else's word for it, go see for yourself! There is no credit card required or anything like that. It's completely free to try.
Wealthy Affiliate is a training program that teaches you how to do affiliate marketing. Affiliate marketing is an avenue where people can earn money promoting other people's products or services. This is the best place for any beginner to learn because they have a conducive step by step training that will bring you through every step of your journey.
I would also like to see a forum built into the platform. Wealthy Affiliate has a unique way of building a community and I understand why they shy away from a standard forum type of format. Instead, they want to promote live chat sessions, blog posts, private messaging, and public questions where people can comment below. This type of setup is pretty cool at times, but I also do enjoy forums where I can just browse by topic.
As merchants switch their sales to e-commerce, online marketplaces for handmade goods, like Etsy and ArtFire, make it extremely easy for artisans who can produce a steady supply of quality handmade products, such as crocheted blankets or unique painted glassware. If you have a unique craft, this is a good way to earn income while you're at home, doing what you love.
hi jack, I have been doing a lot of research on this company and have not found an answer to a specific question I have. I understand that you are promoting a product, specifically something you are passionate about. However I wanted to know if there was help I could get to find something to promote since I do not have a specific product I want to start my business on.
If you have the expertise or a passion or interest for a subject, you're ready to start making money with a blog. With a service like Blogger (www.blogger.com), you can start up your blog totally free. You can also create your own site and secure your own hosting for a low price, which is generally the route I recommend, as many free blogging sites have restrictions on what you can say or do, including making money or advertising.
Anyone considering a drop shipping business should seriously consider leveraging Amazon.com to grow their business and learn more about becoming a profitable Amazon seller, because Amazon is an established marketplace that people already trust and has an existing customer base. Eventually, you should also consider having your own online store as well.
REASON 2. Unmatched Support. The Wealthy Affiliate community provides access to a live online marketing Encyclopedia culminated by 1 million + members. You can also interact with members via 24/7 live chat feature, private message members, and even contact owners Kyle and Carson directly. No other program on the market offers this much support, which makes it great even for beginners.
I provide personal support and coaching to everyone who signs up with my affiliate link. I respond to every private message I receive and I cater my response according to each individual needs. The advices that I give are not those one sentence answers, I give detailed and clear guidance. And I also do a thorough review on the websites that my referrals create. It will benefit a lot to people who needs an expert eye, and that's why I am doing this. For your information, each website review that I do, I spend almost 30 mins to an hour, which is a lot of time, considering the amount of request that I receive. That's because I truly care about my referrals' success.
Udemy.com – Udemy is an online training platform where "instructors" can create courses and sell them to "students". There are some extremely high-quality courses on Udemy created by high-quality instructors who really have made a lot of money online, but there are a lot of very low-quality courses as well. Most of the higher quality courses are quite expensive, sometimes exceeding $100. While the training might be good, the training on Wealthy Affiliate is excellent as well, plus you get all the tools, community, and support included as well. Once again, I believe Wealthy Affiliate is the better option.
Free Membership is not just a free trial, but a Real membership account with no expiration date. You get access to "Getting Started Guide", a free keyword tool, live chat for 7 days, 2 free websites with sleek templates, and the ability to interact with the community. This membership allows you to get a feel of what Wealthy Affiliate is all about and how people interact to build successful business in their niche.
Needless to say, I was blown away pretty quickly. Even by signing up for their free membership option, it was very apparent that Wealthy Affiliate does things differently. The community, recorded training, live ongoing weekly training sessions, live chat and support options, and business-like approach for beginners to pros alike really blew my mind.
Wealthy Affiliate is also very strict on spam, which in the end is a GOOD thing, but I have to be careful sometimes about promoting my sites or referencing them. Sometimes I do have valuable information on my site that I think could help people during live chat sessions or Q&A's, but I don't share because I don't want it to look like I'm spamming. They do allow people to promote their sites in certain areas, but in order to keep the community from filling up with self-promotion spam, there are times when it is best not to share certain information from outside sources, especially my own sites.
However, if you want anything that they don't have – adding any additional code to the site is difficult. There are advanced marketing features like Schema for events, music, business info and reviews that they are adding at some point – but have not yet. Adding pixels, retargeting tools, custom share buttons, custom email collection tools – all are either difficult or unavailable.


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Hotel Casablanca
|L.A. Lazi feat. Deerovy
|Hotel Casablanca
|Release Date
|Dance > House > Vocal House
|© Grimmalex Music
Promotion Text
"Hotel Casablanca" – party, summer, beach…
L.A. LAZI, the 24-year-old Austrian DJ with Albanian roots presents his first single "Hotel Casablanca". Mostly known as one of the familiar faces and club-DJs of the party scene in Graz, L.A. LAZI has now decided to go one step further: writing, producing and releasing his own songs, since music has always been his passion that gave him motivation and power. He invited his musical colleague DEEROVY to sing the lead vocals for the track and created his own and unique sound, inspired by the beaches of L.A. and the parties there. In short: L.A. LAZI's brand new single "HOTEL CASABLANCA" is the ideal radio and party sound for the summer! A perfect beat carrying summer feeling, good vibrations and the spirit of beach parties… In addition to the radio version, especially designed for being part of every good radio program, "HOTEL CASABLANCA" is also available as "Dirty Club Version", for those who like it dirty ;-) "Every day we work so hard in our jobs and we are diligent to pay our bills. But we also need time for life! It's time to party like the superstars!", says L.A. LAZI. Whenever he switches on his turntables, party is guaranteed! So, as the song says: "let's have a really awesome party"… and a great summer! Release: 08.06.2017


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How safe are gadolinium agents?,
Stability of gadolinium-based contrast agents depends on structure. Low stability is linked to nephrogenic systemic fibrosis and gadolinium presence.
Since the 1980's gadolinium-based contrast agents (GBCAs) have been used in MRI to aid diagnosis. Meanwhile around 300 million patients worldwide have received GBCA. The strong paramagnetic properties of gadolinium make it an excellent contrast agent. However, the free gadolinium ion (Gd+3), a heavy metal ion, is toxic for the body. To prevent toxicity, gadolinium is chelated with a ligand. The dissociation of gadolinium from the chelate depends on the kinetic and thermodynamic stability as well as the stability against competing ions. Macrocyclic agents have a higher stability than linear agents.
Nephrogenic systemic fibrosis
In 2006 first reports of the association between nephrogenic systemic fibrosis (NSF) and GBCAs appeared. NSF can progress to a debilitating disease and is potentially fatal. Grobner et al. reported that GBCAs can trigger NSF in patients suffering end stage renal failure. Castillo noted that "at the time it was common to give triple doses." Patient related risk factors for the development of NSF include severe renal insufficiency. Hence, administration of GBCAs to patients with impaired renal function in clinical departments became restricted. In 2010 an EMA report addressed the issue of NSF risk and GBCA. Linear GBCAs were considered to pose a high risk for NSF. Castillo added, that "macrocyclic GBCAs on the other hand were considered to be quite safe".
Gadolinium presence
In 2014, Kanda et al. reported on the occurrence of T1 hypersensitivities in the brain tissue of patients with normal renal function who had received multiple doses of GBCAs. The T1 hypersensitivities were linked to the presence of gadolinium in the brain. However, any clinical significance of this finding has not been demonstrated to date. Currently it is thought that the degree of gadolinium presence depends on the GBCA class. In particular, linear GBCAs are associated with T1 hypersensitivities and gadolinium presence in the brain. The current literature suggests that macrocyclic GBCAs do not cause T1 hypersensitivities. This is reflected in the current EMA recommendations (2017) on GBCAs: The whole body marketing authorizations of linear GBCAs gadodiamide (Omniscan™), gadopentetic acid (Magnevist®), gadobenate (MultiHance®) and gadoversetamide (OptiMark®) should be suspended in the EU. In contrast, no such restrictions were imposed on macrocyclic GBCAs.
Clinical significance
T1 hypersensitivities and gadolinium presence in the brain has been observed in the brain area of dentate nucleus, which is responsible for planning, initiation and control of voluntary movement. Recently, results of a study investigating the occurrence of cerebellar symptoms after serial administration of a macrocyclic GBCA were published. No sign of cerebellar toxicity was found. "Further prospective research is required to confirm these results", Castillo added.
Castillo recommended that radiologists should observe the following basic rules: avoid GBCAs when not necessary, review protocols regularly and move away from double dose. Above all "the guidelines should be followed and applied as necessary", Castillo concluded.
Stability is a key parameter of GBCAs. NSF and gadolinium presence in the brain are predominantly associated with the less stable linear GBCAs. The mechanism of gadolinium presence is unclear, and any potential clinical significance of this finding has not been demonstrated, and should continue to be researched.
Castillo was asked where he would see the GFR for which Gadovist® is safe. According to the ESUR guidelines Gadovist® can be used in patients with GFR ≥30, Castillo replied.


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Originally from Bilbao in Spain and now living in Belgium, Patricio B is a multi-instrumentalist, singer-songwriter and actor. His releases include 2010 album El Beso and 2012 album Jijí Jajá. His single Una Mujer Para Mí was released on the Warner Brothers label in 2014.
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Alumni Office | International School of Geneva | 62, route de Chêne, CH-1208 Geneva | +41 22 787 25 55 | firstname.lastname@example.com


text:
Follow the distant voice of Anita Moorjani as you are led into a state of deep relaxation.
Excerpt from:
Deep Relaxation Echo Meditation
Follow the distant voice of Anita Moorjani as you are led into a state of deep relaxation.
Excerpt from:
Deep Relaxation Echo Meditation
4.5 hours of blissful and relaxing music to meditate or work to.
See the original post here:
432 hz DNA Healing/Chakra Cleansing Meditation/Relaxation Music
Website/Blog: www.seeyouinsleep.com Sit Back, Relax + Listen
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Tibetan Singing Bowl Meditation: Session 51
Download here: http://www.rashanasoundessences.com/meditations/finding-love-meditation/ Personal Sessions: http://www.rashanasoundessences.com/channeling/ Fa…
Visit link:
Finding Love Meditation – Release Subconscious Beliefs to Meet Your True Love
Schumann Resonance Meditation 7.83 Hz
View post:
Schumann Resonance Meditation 7.83 Hz
Spiritual Reality The Ultimate To Meditation. ?????????????????????????????????? ????????????????????????????????????? ?????????????? 3 ?????????????????????…
Read the original here:
Spiritual Reality Power Of Meditation (Techniques) 1080P Full HD
you are very cute like puppy ankles.
Original post:
ASMR Ear to Ear Guided Meditation to Relieve Anxiety and Stress (Softly Spoken AUDIO ONLY)
hypnosis meditation.
See the rest here:
Self-Hypnosis Meditation: How to Find True Love
Namaste! Welcome to a new series called The ASMR Lounge where the goal is to provide both a visually and aurally ASMR inducing, relaxing binaural experience …
Read more from the original source:
The ASMR Lounge #1 – Introduction – Whispered binaural session for relaxation, meditation & sleep
Whether man or woman, the Shakti energy dwells in all.
The rest is here:
Meditation – Bringing To Life The Inner Shakti Goddess Energy


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⏵ ⏵ ⏵ This role is for a contractor position and will be processed through a third-party Managed Service Provider. This is not a full time employment position at GoPro.⏵ ⏵ ⏵ About GoProGoPro makes it easy for people to celebrate and share experiences. We believe life is more meaningful when shared. We build cameras, software, and accessories that help the world share itself in immersive and exciting ways.GoPro is a global movement whose business is driven by shared experiences. We celebrate diversity. We practice inclusion. We foster belonging. We demand equality. And we share the experiences of individuals and communities who also hold these values as core to who they are. From Bucharest to Munich, Silicon Valley to Shenzhen, we are dedicated to building a company that reflects and honors the diverse global communities where we live, work, and play.The RoleWere looking for a passionate, well-rounded, kickass Digital Project Manager to join the GoPro Studio team. Were committed to better understanding our diverse global customers; we want to know who they are, what motivates them and how they connect with our products and services. Were building a new web team to create online solutions that inspire, captivate and convert. The Digital Project Manager will play an integral role, managing the day to day projects that push forward our branding and customer engagement, while guiding the team to achieve its highest potential.Us: a high-fiving, humorous, hard-working team of talented people with a passion for killer creative. You: A Digital Project Manager who drives initiatives and is eager take on any challenge GoPro has to offer. Could this be you?What Youll DoManage daily communications between the team and stakeholder teams. Examples of stakeholders teams include eCommerce, CRM, Engineering, Community and Product Marketing
Track project progress against handoff dates and sprint schedules
Manage team capacity and resourcing using story points
Manage the day to day of the Digital team, operating in a modified SCRUM process
Facilitate meetings between the team internally and with company stakeholders. Sample meetings include Kickoffs, Daily Stand-Ups, and Stakeholder Review meetings
Help the team stay focused on work by communicating work priorities and protecting them from external interference
Manage risk by proactively engaging in problem solving and contingency planning when team impediments arise
Collaborate directly with the CRM, eCommerce and Community teams to receive and manage requests, end-to-end
Facilitate collaboration between the team
Help the team define processes and workflows, then helping the team execute and excel at them
Foster team values and principles by encouraging/coaching the team to adhere to the processes developed by the team
Skills We're Stoked About
6+ years of project management experience at a relevant brand or agency
BS/BA degree in Marketing or related field preferred
Experience using resource/project management tools in a work environment
Strong interpersonal communication and collaboration skills
Experience in Website and CRM projects and processes
Experience working in a SCRUM process a plus
Ability to organize information and concisely present issues, recommendations and conclusions
Superior written and verbal communication
Ability to excel with with little direction
Strong attention to detail
Strong problem solving skills
Must work at our HQ in San Mateo, CAGoPro HighlightsLive it. Eat it. Love it.Two hours during your workweek to explore your passions and capture it with your GoPro.
Employee commuter shuttles throughout the Bay Area (San Francisco, Oakland, San Jose).
An awesome Wellness program including on-site fitness classes, health screenings and more.
A subsidized on-site cafeteria.
GoPro is an Equal Opportunity Employer.⏵ ⏵ ⏵ This role is for a contractor position and will be processed through a third-party Managed Service Provider. This is not a full time employment position at GoPro.⏵ ⏵ ⏵
Digital Project Manager (Contract)
Multiple Locations
|Required Experience:
|0 year(s)
|Employment Type:
|Salary Range:
|Not available
Posted 3 days ago


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Lewisville is a vibrant city, where there's never a reason to be bored! Western Days Festival, Highland Village Balloon Festival, Lebanese Food Festival etc. are some of the many held here on a regular basis all-through the year. Enjoy free concerts in summer! Catch live concerts, Broadway-style musical and fine art displays at Grand Theater at different times of the year. Greater Lewisville Community Theater is a delightful yet inexpensive way to experience theater.
Play disc golf along the lake at Lake Park. The campground offers excellent facilities. Hike, bike or kayak at Lake Environmental Learning Area, a fantastic nature preserve. Any time of the year, enjoy fishing at Fishing Barge! Have fun-action times with kids at Zone Action Park! Don't miss out the activities at Wayne Ferguson Plaza- weekly concerts and more. It's lovely with water features and is a fun place to have coffee with friends or for families to enjoy a picnic. Head to lake at Castle Hills for a great golf-outing.
Tour Witherspoon Distillery for great sipping and learning how bourbon comes to be! Larue Vineyards is a hot-spot for oenophiles. Yearning to try American, Mexican Italian, Japanese cuisine? Try popular eateries like Cristina's, BJ's or Jinbeh. Shop till you drop at Vista Ridge Mall, Lakepoint Towne Crossing, Lewisville West and more!
Find reputed builders like Pulte Homes or Village Builders in NewHomeSource's detailed listing for new homes for sale in Lewisville, if you prefer hassle-free ready-to-move-in homes. For prices ranging between high300's-low500's, secure magnificent 200-sqft3bedroom2bathroom homes to huge 3800sqft5bedroom4bathroom ones. Tilson or Newport Builders offer custom/on-your-lot homes if you prefer that.
Located 20minutes from Dallas and 40minutes from Fort Worth, Lewisville is a gem! Secure your dream home for the best price from us, enjoy the best life can offer. Check out the new homes for sale in Lewisville, TX, now!
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from $369,450
Creeks of Legacy
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Christianity not mysterious: or, A treatise shewing, that there is nothing in the gospel contrary to reason, nor above it. To which is added, An apology for mr. Toland
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Christianity Not Mysterious: Or, a Treatise Shewing, That There Is Nothing ...
John Toland
Ingen forhĺndsvisning tilgjengelig - 2015
Christianity Not Mysterious: Or, a Treatise Shewing, That There Is Nothing ...
John Toland
Ingen forhĺndsvisning tilgjengelig - 2018
Vanlige uttrykk og setninger
Adversaries affirm agree answer Apostles Assertion Atheists Author Baptism believe better Body call'd Catechumen Ceremonies Ceres cern CHAP Chri Christ Christianity Church common contain'd Contradictions contrary to Reason Design Discourse Divine do's Doctrines Evidence exprefly Faith fame Fathers Gentiles gible Gospel Heathen Heresy Honour Ideas ignorant initiated intelligible Ireland Jesus Jews JOHN TOLAND Judgment Kjiowledg Liberty lieve ligion likewise Lord Matter mean ment Mind Miracles MTSTERT Myste Mysteries Name Nature neral never Notions Number Objections obscure Observations Old Testament Opinion Ovid Papists Passage Persons perswaded Philosophers plain preach present pretend Priests Properties Prophets prov'd prove racter real Essence Religion reveal'd Revelation Rites Scrip Scripture secret Sect Sect.II sense shew signify Socinians Soul speak stery stian sure Testament ther thing thought tion Toland true Truth ture understand unto wherein whereof Wisdom Words World Writings
Populćre avsnitt
Side 97 - God : praying always with all prayer and supplication in the Spirit, and watching thereunto with all perseverance and supplication for all saints; and for me, that utterance may be given unto me, that I may open my mouth boldly, to make known the mystery of the gospel, for which I am an ambassador in bonds: that therein I may speak boldly, as I ought to speak.
Side 55 - The statutes of the Lord are right, rejoicing the heart : the commandment of the Lord is pure, enlightening the eyes. The fear of the Lord is clean, enduring for ever: the judgments of the Lord are true and righteous altogether.
Side 100 - Gentiles, if ye have heard of the dispensation of the grace of God, which is given me to you ward. How that by revelation he made known unto me the mystery...
Side 129 - He is, and that He is a rewarder of them that "diligently feek Him...
Side 59 - Let no man say when he is tempted, I am tempted of God: for God cannot be tempted with evil, neither tempteth he any man ; but every man is tempted, when he is drawn away of his own lust, and enticed.
Side 101 - Even the Mystery which hath been hid from ages and generations, but now is made manifest to His saints, To whom God would make known what is the riches of the glory of this Mystery among the Gentiles, which is Christ in you, the hope of glory...
Side 47 - If I do not the works of My Father, believe Me not. But if I do, though you will not believe Me, believe the works ; that you may know and believe that the Father is in Me, and I in the Father.
Side 143 - Unto whom it was revealed, that not unto themselves, but unto us they did minister the things, which are now reported unto you by them that have preached the gospel unto you with the Holy Ghost sent down from heaven; which things the angels desire to look into.
Side 63 - For who maketh tbee to differ from another? and what haft thou that thou didft not receive ? now if thou didft receive it, why doft thou glory as if thou hadft not received it ? Heb.
Side 130 - For we are saved by hope : but hope that is seen is not hope: for what a man seeth, why doth he yet hope for ? but if we hope for what we see not, then do we with patience wait for it.


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Try Scuba Diving Tour Panama City Beach
- Adult (18 & up)
- $101.97
- Child (10 - 17)
- $101.97
Panama City Beach
Scuba Diving in Tours in Panama City Beach
This tour is for beginners so no experience is required!
- Adults & children ages 10 and up
- All tours are private
- We provide absolutely everything
- Free videos and pictures included
- All tours are in the ocean on a Reef
- Guaranteed to see aquatic life and fish
What to Expect
Fundamentals Briefing:
Your dive professionals will start you out from the beach where they will go over information and fundamentals of scuba diving. Usually 10-15 minutes.
Getting Comfortable:
Your dive pro will start you out in waist deep water (3ft) to get you comfortable with breathing underwater and teach you some basic scuba diving skills. Everyone learns scuba and gets comfortable differently and at different timing which is why all of the tours are private with your own dive professionals for you and your group.
Guided Scuba Dive Tour:
After the dive pros get you comfortable and they are comfortable with you, they will give you an underwater tour, showing you all the beautiful aquatic life and fish. They'll also capture some of those memories on video!
1.5 – 2 hours (depending on your group size and how you do in the water)
Confirmation Email
After booking you will receive a confirmation email that will have all of the details for your reservation, including what to expect, what to bring, and where to check in.
After you make your reservation you will receive a confirmation email that will include all the details of your reservation including what to expect, what to bring, and where to check in. After booking we will pair you and your group with your own personal dive professional. Your instructor will be calling you 30 minutes before your tour to make sure you don't have any problems finding our dive site.
We help you with everything from before the tour, guiding you into our dive site, to after the tour, downloading videos and pictures. We take care of all the details in between so that you don't have to worry, and your tour goes perfect.
Share With Friends
Are you a dive professional and want to work with us?
E-mail your resume to [email protected]


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All MidWest Life Stages travel dog crates include handles for easy carrying and a plastic pan for comfort inside the crate so your pup isn't sitting on the metal bars. Metal crates like this one are great because you can see your pet from all angels since there there are no hidden sides. Midwest has seven different sizes for your dog that adjust to his growth and the divider panel is a huge advantage over soft dog travel crates. Overall, metal dog travel crates are the most optimal option for many pet owners, especially those who travel in cars very often.
The best crate is the one which costs not much, which is easy to carry, your pet should love it. The pleasant bonuses are when there is a napkin already and you don't have to buy anything. Look at the variants in the guide. There's only one that suits everything I said, and that's because I have this crate for a long period of time and recommend to everybody (I'm talking about The Go Pet Club Soft Pet Crate).
Remember to measure your pet for the paw-fect fit. Frisco XX-Large Heavy Duty Double Door Dog Crate is constructed to be strong and durable while providing your pet with safety, security and comfort. Two large doors — one on the front and one on the side — are easy to open, close and securely lock, with three latches on each. Durable drop-pin hinges keep your pet safe and secure. And an included plastic base pan sits on the bottom of the crate for easy cleanup and for your dog's comfort. No tools needed for assembly. And with a protective, black electro-coat finish, it's made to last.
Favorite Top Load Portable Carrier – Pet owners with very small and teacup dog breeds who are looking to take short trips, this can be the winner. Favorite's best dog travel crate alternative has a good looking design and is the cheapest crate of all listed here. However, it's only good if you're not traveling long distances since the materials appear to be low quality and I wouldn't trust this on a plane.
My boyfriend and I brought home a male Chihuahua when he was 6 weeks old , He is now 10 months and we are still having potty training issues . We have trained him to sleep in his crate through out the night but For the last couple weeks, he will wake up and poop around 6:45 am every morning in his crate even after being taken out !! Sometimes he'll poop in his crate before we wake up. We set his last potty break at 12 am at night . We stopped giving him treats and water after 8 pm and were still getting the same problem . My boyfriend wakes up at 6:30 am before he goes to work to take him out but he only pees and about 15 minutes after being brought back inside he'll poop all over his crate and step all over it . We have tried puppy pads in the crate but all he did was rip them up so we stopped using them at 6 months . I am thinking about getting a kennel for him to lay in at night because his crate may be too big for him . We've also tried letting him sleep with us during the night and taking him on a potty break at 6:30 am and once were about to leave for work , we put him in his crate and we find him peeing or pooping in the crate . Unfortunately , we had to move his crate to the kitchen because that is the only room where we have hardware floors. ( We use to have his crate in the bedroom with us but he started kicking the black panel out his crate and digging at our carpets and scratching at our walls . ) I take my break from work at 12 pm so hes crated 7:15 am – 12:00 pm and hes always dry when I get home from break then I go back to work 12:30 – 4:30 and when I get home to take him out , hes dry ! I feed him and take him out once I get home and then its play time ! He is fed dinner at 7:45 pm and then hes taken out immediately and he goes potty and then playtime again until 11 pm with his potty break following at 12 am and him going back in the crate for bedtime . I've researched and I've asked experts but no one seems to have the right answer. We've tried putting him on new schedules as well as reducing his crate time through out the day . Please Help !!
I'm very happy with this crate's size. One thing I didn't notice was that it does require some assembly (not super hard, but it does take 2 people); I thought it was going to be like my 48" crate that folds. The quality is awesome, especially for the price. I'm very impressed with the Frisco line of products overall, the price is unbeatable. The shipping for Chewy is always great and ofcourse free for a purchase like this, I'm a happy camper.
AmazonBasics Black Soft-Sided Carrier – Once again, Amazon offers its alternative to the best travel dog crate for a cheaper price. This time, it may well be worth it unlike with the plastic travel dog crates. The design of AmazonBasics pet carrier is much more simple, but the materials used are good quality and if you don't require expandable storage space, you can get this one for half of what PetPeppy costs.
Reduce housebreaking time and help resolve barking, chewing, and behavioral problems with these collapsible dog crates. As dogs have a natural instinct to not soil or eliminate in their area of rest or sleep, crate training is widely recognized as an effective way to house or potty-train your dog. Whether you are in need of a crate for a small or toy-sized dog, medium-sized dog, or large dog, you are bound to find a crate that will perfectly accommodate your dog, as these Petco collapsible dog crates are available in five different sizes. Our Petco Premium 2-Door Dog Crates boast heavyweight wire construction with a sophisticated hammer-tone metal finish. Our improved baked powder-coat finish strongly adheres to the metal wire adding lasting durability and resistance to rust. These convenient wire dog crates feature two doors that provide easy access for your dog to easily enter and exit, as well as dual safety locks on each door to keep your pup securely inside. These Petco exclusive dog crates are easy-to-clean and also include a slide-out plastic pan. These collapsible wire dog crates are perfect for dogs that are constantly on the go as they require no assembly. They also set up in seconds and fold flat for compact storage and travel. An added benefit for puppies, all sizes include a divider panel that allows you to create an initial partition for when your puppy is still small and remove it after your puppy's growth spurt. A crate pad is not included; however petco.com carries a variety of crate pads and blankets if you choose to add a layer of warmth or soft comfort for your dog.
Wire dog crates are ideal for pets with long coats or those who live in warmer climates. The continuous air flow keeps them cool while the open design allows them to see their surroundings. Wire and metal dog crate sizes range from X-Small, for a max weight of 20 LBS, all the way up to XX-Large, for a max weight of 140 LBS. While it's good to know your dog's weight, you can also reference our crate sizing guide to get a better idea of which size works for each breed.
Use a smaller crate. However, because your pup is use to peeing freely, transitioning will require more of your attention. You will have to take your pup out for multiple bathroom breaks. Then gradually increase the crate time. All up until your pup can hold its bladder for about 8-9 hours. Giving treats as soon as your pup finish using the bathroom outside, give a favorite treat. I wouldn't give my pup a treat if she didn't use the bathroom during her bathroom break. My pup is now 5 months old and the last accident in our home was when she was 2 months old. It was my fault tho. I forgot to take her to the bathroom before taking her upstairs for her bath. She accidentally pooped upstairs. She didn't know how to use the stairs yet. But she is an awesome pup. I love her. She respects me and what I ask her to do.
Our 48-inch XXL Dog Crates accommodate dogs weighing 91-150 pounds. See dog crates size guide if you are unsure if the XXlarge dog crate is appropriate for you pet. Manufacturers of dog crates have their own measure of Large, XL, XXL crates - please check the dimension of our XXL dog crates when making a purchase. See all dog crate sizes on our Dog Crates and Dog Cages page.


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Home Security Systems can increase the value of your home by $574
A lot of people think it is costly to consider home security systems in Newark. However, not installing one could cost you so much more. There is nothing more important than having that peace of mind when you know your home is safe. With the best home security systems, your home is safe from intruders. This is one of the main reasons why people install home security systems. Considering that homes without home security systems are almost three times more likely to be burglarized, it is important to consider getting one of the best home security systems for your home.
Fair price breakdown
In as much as installing some of the best home security systems in Newark might seem to be costly, the costs are relative, and can be managed with some foresight. You have to plan and come up with a good budget. One of the first things you need to look into, is the initial cost of the equipment that will be required. This includes sensors and cameras. You can spend some time shopping around and reading through reviews to know which ones are more effective before you commit to making a purchase.
Estimated final cost for home security systems
|Fair Price
|Security System Cost
|1 System
|Security System Labor
|6.2 Hours
|Security System Job Materials and Supplies
|1 System
|Totals - Cost to Install Home Security Systems - 1 System
|Average Cost Per System
Find the Best Costs on Home Security Systems - Newark, 07102
Another issue that you will need to look into what the installation will cost you once it is done. This is another place where you might need quotations from different contractors before you can settle on the home security systems that will meet your security needs and your budgetary requirements. The good thing is that these days there are so many Newark home security system providers around, so you have quite a number of options before you settle on an ideal contractor. Make sure you discuss the monthly or annual fees necessary for monitoring your home security system Newark. This should also include costs for repair and maintenance, so that you are clear before you commit to the contract.
Essex County Home Security Systems FAQ
Last Updated: Oct 21, 2019
Local pros & Availability
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text:
Post Office to deliver better banking
Hailing the Post Office as a 'great British institution', Lord Mandelson yesterday declared he wants to see a full range of banking services on offer at its 11,500 branches.
The world's first 'Post Bank' was founded here in 1861, and the Business Secretary argues it's time for us to return to our roots.
His accompanying consultation paper, however, was striking in its woolliness. Feedback is requested, for example, on whether customers want our new Post Office bank to be 'trusted',' sustainable' and 'accessible'.
And nowhere did it mention the key matter at hand, which is what company will provide the financial services at the new 'People's Bank'.
It's clear the Royal Mail can't do banking by itself. It seems to have enough trouble delivering letters. Instead, the Post Office will partner up with a fully-fledged financial services player.
The reason we are not being consulted on this topic is the winner of this coveted position is already a sure bet. It will be that great British institution known as Bank of Ireland. The bank has offered a limited range of services, such as savings accounts and the occasional mortgage, via the Post Office since 2004.
Bank of Ireland has, in that short time, managed to soak up £8bn of deposits from Post Office customers.
The Post Office is committed to this alliance until 2020, and as such, it is hard see how another firm could muscle in.
That's highly unfortunate. There is nothing wrong with attracting foreign banks to the UK - indeed, we need all the competition we can get after mega-mergers such as Lloyds-HBOS.
But Bank of Ireland is hardly in robust health. Like the rest of the Irish banking sector, it has been crippled by a property implosion that rivals the one we saw in Britain. In the first six months of the year, its underlying losses nearly tripled to £885m.
It has been the beneficiary of a controversial blanket deposit guarantee by the Irish government, as well as a recapitalisation plan. It is planning to put £14.5bn of toxic loans into Dublin's National Asset Management Agency.
This is hardly the kind of institution to restore the public's faith in financial services, which Lord Mandelson declares as his principal goal. The Business Secretary needs to be more creative. Why not get one of the UK's existing building societies involved instead, or merge the Post Office's banking activities with the 'good' Northern Rock assets?
Despite the Royal Mail's desperate need for extra revenue streams, the government has not given these ideas any thought, preferring to stick with an existing deal that delivers too many benefits to Bank of Ireland and not enough to the UK taxpayer. Indeed, once you strip away the rhetoric, this consultation amounts to a bag of empty words.
The document proposes that the all-new Post Bank could offer current accounts to customers across the country, but Bank of Ireland already has plans in place to do so. Enjoying a plum position in the Post Office's vast branch network has clearly been a boon to Bank of Ireland. But the key question for Lord Mandelson is whether it is such great news for consumers.
Hollow victory in EU
UK officials were yesterday declaring victory in the battle over European Union financial regulation. Three authorities will be created to oversee the EU markets, but none of them will be able to take decisions that impinge on national budgets. This 'fiscal sovereignty' issue was a key concern for the UK delegation. What's more, the power to declare when a financial crisis has flared up has been removed from the European Commission - under France's dreaded Single Market Commissioner Michel Barnier - and handed to the European Council, where Britain's weight will be more keenly felt.
Yet in reality Britain remains worryingly marginalised in a debate of key importance to the City. By focusing our political firepower on issues like 'fiscal sovereignty' the UK has missed the bigger picture, which is its denuded status in institutions that will wield massive sway. For example, the new European Systemic Risk Board that will monitor the markets for looming dangers will be dominated by European Central Bank president Jean-Claude Trichet and other eurozone officials.
And, as the latest grandstanding by Nicolas Sarkozy proves, Gordon Brown's decision to push for an EU foreign policy post for political neophyte Baroness Ashton has left us pitifully under-represented on the European Commission. Sarkozy has helpfully reminded us how determined some Continental politicians are to chip away at London's status as a top financial hub. The evidence thus far is that the UK is doing a pitifully poor job of defending it.
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Aperture: Asia & Pacific Film Festival In Time to Come, CCA 25 – 29 March
Sunday 25 March 2018
Set in Singapore, In Time to Come follows the ritualistic exhuming of an old state time capsule, and the compilation of another. As enigmatic remnants of life from 25 years ago emerge – a bottle of water from the Singapore River, a copy of the Yellow Pages, a phone charger – today's selection of items are carefully primed for future generations to decode. Interwoven are carefully composed shots of moments we rarely think to preserve: the in-between minutes of daily life spent waiting for things to happen, shot in locales as diverse as the lush jungle to a residential district infused with haze.
This picture of Singapore is both alluring and startlingly strange, already slipping beyond the present its inhabitants struggle to seize it in their hands. Like the time capsules in the film, this film itself is a vessel that transports us through past, present and future, a prism through which we glimpse alternate realities. The latest film presented by observer Tan Pin Pin builds on her previous bold and daring work, but leads its audience into uncharted cinematic territory.
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text:
Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis
Editors: Devarajan, Padma, Dandekar, Prajakta, D'Souza, Anisha A. (Eds.)Free Preview
- Unique in that this is the first book focused on one aspect of intracellular delivery that focuses on cancer and infectious diseases
- Essential advanced reference on receptor and receptor-mediated drug delivery
- Provides research that demonstrates high efficacy and decreased toxicity
- Serves as critical research for drug discovery in treating cancer and infectious diseases
- Each chapter includes a brief overview of the receptor and its occurence, alterations in receptor expression, recognition domain, binding of substrates to ligands, Structure activity relationship of substrate/ligand for selective binding, antagonist of ligand binding, natural and synthetic ligands, ligands in clinical development and clinical studies, targeted drug delivery strategies and conclusions and references
Buy this book
- eBook $129.00
price for USA in USD (gross)
- Digitally watermarked, DRM-free
- Included format: PDF, EPUB
- ebooks can be used on all reading devices
- Immediate eBook download after purchase
- Hardcover $169.99
price for USA in USD
- Free shipping for individuals worldwide
- Usually dispatched within 3 to 5 business days.
- About this book
This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in , Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. As a result, many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also emphasize commercial products, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. Finally, we briefly discuss the regulatory and toxicity issues that may be associated specifically with the RME approach of intracellular drug delivery.
- About the authors
Padma V. Devarajan, PhD (Tech), is Professor in Pharmacy and former Head, Department of Pharmaceutical Sciences and Technology at the Institute of Chemical Technology (ICT), Mumbai, India. Her research interests include nano carriers for targeted delivery in cancer and infectious diseases, innovative approaches in scale-up of nano drug delivery systems (DDS), bioenhancement strategies, and mucosal DDS as alternatives to parenteral administration for protein and nucleic acid delivery. She is editor of Targeted Drug Delivery-Concepts and Design, published by Springer, author of several book chapters and has publications in peer reviewed high impact journals. She is a member on the Editorial board of European Journal of Drug Metabolism and Pharmacokinetics and the Asian Journal of Pharmaceutical Sciences and peer reviewer for a number of International Journals. She has served as Board Member, Member on the Board of Scientific Advisors , Chair of the Young Scientist Mentor Protégé Sub-committee of the Controlled Release Society Inc., USA and Chair- Outstanding Paper Award Committee, Drug Development and Translational research. Prof. Devarajan is a nominated Fellow of the Maharashtra Academy of Sciences, India, and recipient of number of awards including the American Association of Indian Pharmaceutical Scientists (AAiPS) Distinguished Educator and Researcher Award, and Innovation Awards for pioneering research in Nanotechnology and Targeted Drug Delivery Systems. Prajakta Dandekar received her PhD from the Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai. Her doctoral research involved the development of polymeric nanoparticles for natural therapeutic agents. Later, she joined the Department of Macromolecular Organic Chemistry, University of Saarland, Saarbrucken, as a post-doctoral researcher and was involved in formulating nanoparticles of new hydrophobic starch polymers for encapsulating hydrophobic anti-cancer actives. She was the first woman scientist from India to be awarded the European Respiratory Society-Marie Curie Joint Postdoctoral Fellowship (long-term) and conducted the associated research involving formulation of nanoparticles for intracellular siRNA delivery at the Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrucken, Germany. From January 2012 until October 2014, she worked as Dr. John Kapoor Assistant Professorin Pharmaceutical Technology at the Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai. Currently, she is UGC Assistant Professor in Engineering Sciences, in the same department. Her research interests involve design of siRNA-polymer nanocarriers, development of in vitro 2D and 3D cellular models, and developing biopolymer-scaffolds and microfluidic devices for tissue engineering. Anisha A. D'Souza is currently working as Research Formulation Scientist at Piramal Enterprises Limited, Mumbai. She received her PhD (Tech.) in Pharmaceutics from the Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai (ICT, Formerly known as UDCT). She was the recipient of the most coveted and prestigious 'Prof. M. M. Sharma Doctoral Fellowship' at ICT. Subsequently, during her post-doctoral tenure at IIT-Bombay, she has worked on delivery of micronutrients encapsulated nanoparticles incorporated in different cosmetics for improving mother and child health. Her research interest encompasses colloidal drug delivery systems viz., polymeric and solid lipid nanoparticles for enhanced bioavailability, controlled delivery and targeting. She has published research papers and reviews in peer reviewed journals and has coauthored number of book chapters.
- Table of contents (18 chapters)
Intracellular Delivery: An Overview
Pages 3-41
Brain Cancer Receptors and Targeting Strategies
Pages 45-78
Breast Cancer Receptors and Targeting Strategies
Pages 79-108
Cancer of Reproductive System: Receptors and Targeting Strategies
Pages 109-140
Receptors for Targeting Gastrointestinal Tract Cancer
Pages 141-170
Table of contents (18 chapters)
Buy this book
- eBook $129.00
price for USA in USD (gross)
- Digitally watermarked, DRM-free
- Included format: PDF, EPUB
- ebooks can be used on all reading devices
- Immediate eBook download after purchase
- Hardcover $169.99
price for USA in USD
- Free shipping for individuals worldwide
- Usually dispatched within 3 to 5 business days.
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Bibliographic Information
- Bibliographic Information
- Book Title
- Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis
- Editors
- Padma Devarajan
- Prajakta Dandekar
- Anisha A. D'Souza
- Series Title
- AAPS Advances in the Pharmaceutical Sciences Series
- Series Volume
- 39
- Copyright
- 2019
- Publisher
- Springer International Publishing
- Copyright Holder
- American Association of Pharmaceutical Scientists
- eBook ISBN
- 978-3-030-29168-6
- 10.1007/978-3-030-29168-6
- Hardcover ISBN
- 978-3-030-29167-9
- Series ISSN
- 2210-7371
- Edition Number
- 1
- Number of Pages
- Number of Illustrations
- 37 b/w illustrations, 45 illustrations in colour
- Topics


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Same feature set for Classroom Notebook and Class Notebook
Integrate features of the class notebook with the class notebook in classroom. Even though they are both class notebooks, the one in Microsoft classroom is "different" (this is what I was told by a Microsoft person on a webinar when I asked this question) – I see an update was recently made so that teachers can now lock the collaboration space through Microsoft classroom. All the tools for the new class notebook tab don't work with the class notebooks from classroom (specifically - add/remove student teacher)


text:
George Osborne 2015 Budget speech
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