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Workplace education gets easier – and more important
Getting educated used to mean sitting in a classroom. For adult students, acquiring knowledge required enrolling in night courses, aContinue Reading
Learn More In Less Time
Getting educated used to mean sitting in a classroom. For adult students, acquiring knowledge required enrolling in night courses, aContinue Reading
The old saw makes it sound so simple: Put in a hard day's work, get a fair day's pay. Alas,Continue Reading
Company culture. Employee engagement. Corporate values. Servant leadership. At one time maybe these were just fancy buzzwords, but now theyContinue Reading
Earth Day is just around the corner. The holiday provides an opportunity for businesses of all sizes to reflect onContinue Reading
Few of us can achieve the levels of business success attained by Bill Gates, Warren Buffett and Mark Zuckerberg. ButContinue Reading
Traveling can be a nice break in routine. It can also change your life. From Cheryl Strayed's bestseller Wild toContinue Reading
You're good at your job, you're satisfied with your salary and benefits and you like your company and your colleagues.Continue Reading
The organizers of International Women's Day are pushing for "gender parity," a situation where women enjoy equal earning power andContinue Reading
A question of character The ability to persuade others often means the difference between success and failure. This is as trueContinue Reading
In this era of dwindling job security and a mass migration toward gig work and freelancing, nearly everyone is seekingContinue Reading


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People tend to think of evaluation as something you do at the end of a campaign. In fairness, doing a full evaluation at the end is a massively important part of any campaign strategy. But it's also helpful to evaluate as you're going along. Lots of brands make the mistake of closing their ears to ongoing issues and save any feedback for the end of campaign evaluation.
This A/B test indicates that engagement is one problem, but your subject lines are an even bigger problem—and one you can solve right away. CTR rates are understandably lower among the less-engaged group, but you saw engagement increase with a punchier subject line, so there is room to improve CTR among cold leads. CTR rates are higher in the more engaged group, but with a better subject line, this rate could go through the roof.
Note: if your email is not run by a Microsoft exchange server, the you must leave your computer turned on and Outlook running for the automated replies to be sent. If you're not sure if your email is setup in this way, ask your IT department. If you don't have an IT department, then your email isn't likely setup on an MS Exchange server and you should leave your computer on.
I wish I'd known that email marketing isn't about the channel or the sending technology, it's about the individuals receiving the email. It's about making the email offer/content as relevant and valuable to them as possible. It's about leading with marketing and letting the technology bring it to life, not the other way around. Kath Pay (Founder of Holistic Email Marketing)
The reply using a specific template rule in the Rules Wizard sends your automated reply only once to each sender during a single session. This rule prevents Outlook from sending repetitive replies to a single sender from whom you receive multiple messages. During a session, Outlook keeps track of the list of users to whom it has responded. If you exit Outlook and then restart it, however, the list of the senders who have received automated replies is reset.
Hello, Steven. Nice article. You have hit the nail on the head. I too believe that both old and new marketing needs to compliment each other to get the desired result. I feel that with data from new marketing solution like social media shall be added to old tools like email marketing and direct mailers to make them more efficient and bring real business value. Thanks for highlighting the points.
Great flexibility: Email marketing can work for every business. It doesn't matter whether you sell houses, lingerie, or consulting; you can get lots of sales if you use the right email marketing strategy in the right place. And you can promote practically anything relating to your business—you aren't limited to sending links to your sales pages. Or rather, if your emails are just links to sales pages, you're doing it wrong.
Hi Henneke, Points covered by you are really interesting. So we can assume that one should write & help subscribers as a friend . I'm planning to open my own blog website on Hotel Consultancy and my aim is to create an interested readership before I went to sales part (between 6-12 months). So, instead of posting a blog and start sending email won't be a good strategy. I think I should wait for a dozen or 2 subscribers and then go for email circulation to the interested audience.
I wish I'd known that email marketing isn't about the channel or the sending technology, it's about the individuals receiving the email. It's about making the email offer/content as relevant and valuable to them as possible. It's about leading with marketing and letting the technology bring it to life, not the other way around. Kath Pay (Founder of Holistic Email Marketing)
A significant element of email marketing is relationship. Does a recipient trust you? Does a recipient even know who you are? When an email jumps the gun by forcing familiarity too soon, the personalization comes across as skeevy. Intimacy is earned in real life, and it would appear to be the same way with email. Take this example from my inbox; no one has called me lowercase kevan l lee in years.
Effective email marketing campaigns are designed for all devices on which users can read their emails -- desktop, tablet, and smartphone. Email campaigns that are designed for mobile devices are especially important -- a quality known as "responsive design." In fact, 73% of companies today prioritize mobile device optimization when creating email marketing campaigns.
Head back to your Gmail window. Now, compose a message that you might use frequently, like "Thanks very much for this! I'll get back to you as soon as I can." To set up a canned response, click on the dropdown arrow in the lower right-hand corner of the Compose window, and choose Canned responses, followed by New canned response. You'll have to name the response and save it to make it available.
Use your real email signature: Just like using a real reply-to email address, you want to use real contact information within the email and the best way to do that is to include your contact details in the email signature. Giving your readers the opportunity to contact you or connect with you online is a great way to be personal and build a relationship with them.
What does your current email marketing performance look like? Analyse the performance of key metrics such as Open Rate, Click-through-Rate (CTR), Deliverability Rate, Unsubscribe Rate, ROI. What is working well and what isn't. This can also be internally focused – for example, maybe it is taking a long time to create email content, or the creation process is inefficient.
Low barrier of entry: Email marketing is comparatively cheap. But the learning curve also isn't nearly as steep as with many other tactics. Even if you're not an expert, you can see great results. Just use the three email marketing strategies. Great execution of the strategies improves your results a lot. But even if you make mistakes, you aren't wasting your time.
In addition to linking to Letter Shoppe's designs (available on merchandise that is ultimately sold by RedBubble), the email campaign includes an endearing quote by the Featured Artist: "Never compromise on your values, and only do work you want to get more of." RedBubble's customers are likely to agree -- and open other emails in this campaign for more inspiring quotes.
Email marketing has always been Permission based, but is silently replaced with its brother; Tease Marketing, continuously building on a brand relationship based on mutual interest. The challenge becomes presenting an – already in itself – appealing and attractive message. But how to benchmark your email marketing efforts to fit that new train of thought?
Then, send promotional emails through Auto Responder to your list. Your subscribers will click just 1 same link (main rotator URL), and the rotator will display all the different links to different visitors. Then you can monitor how many links being delivered inside the rotator and stop it when done (You can set it to stop automatically when clicks delivered).

subset: commoncrawl


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Search Tips
Enter your search keywords including Company Name or Keywords. You can also use the check boxes to apply various filters to narrow your search.Displaying 1 - 4 of 4
Type: Profit
Region: Global
Category: Camp, Community Service, Service Learning
State / Province: MT
VISIONS Service Adventures offers dynamic experiences for teenagers that blend construction-based and other service work, cross-cultural immersion, and adventurous exploration. Some programs offer Spanish or French language immersion.
Type: Profit
Region: California, Canada, Central America, Global, International, US, US & CA, US & International
Category: Adventure Travel, After School Outdoor Program, Camp, Commercial Outfitter/Guide Service, Experiential Education, Private School, Public School
State / Province: ON
Evolve Tours organizes experiential outdoor student tours to destinations around the globe. Our outdoor tours in Central, South & North America often include stays at remote eco lodges, adventure activities, and hands-on experiential education.
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Region: Central America, International, South America
Category: Adventure Travel, Community Service, Experiential Education, Seasonal Program, Service Learning
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Broadreach is a leader in adventure and experiential education, operating trips in over 30 countries for middle school, high school and college aged students.
Type: Non-Profit, School
Region: Africa, Asia, Australia/New Zealand, Central America, International, South America, Southeast Asia
Category: College/University, College/University (Non-Rec. or Educ.), College/University Outdoor Education, Conservation Organization, Ecology/Fisheries/Wildlife, Environmental Education Program/Center, Environmental/Conservation Research, Experiential Education
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The School for Field Studies (SFS) creates transformative study abroad experiences through field-based learning and research.


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These deals are so good, they won't stay around long! Add new favorites to your library before the bargains disappear. (more…)
Your Kids Aren't Innocent
Dr. Paul Tripp is a pastor, international event speaker, and award-winning author. Dr. Tripp's latest Parenting conference is now available to stream via Faithlife TV. A streaming license allows you, your group, or your church to replay the event as many times as you want through November 30. Get one now.
From the sentimental images on greeting cards to the flawless young heroes of animated films, we often think of kids as pure and innocent beings who don't suffer from the moral corruption of the adult world. [Read more…]
Get Dangerous Calling Free, Plus Two More Books for under $8
After traveling the globe and speaking to thousands of churches worldwide, Paul David Tripp discovered a serious problem within pastoral culture. Now he is not only concerned about the spiritual life of the pastor, but also the community of people that trains, calls, relates to, and restores pastors if necessary. [Read more…]
Between a Rabbi and Two Imams
Whiter than Snow: Meditations on Sin and Mercy by Paul David Tripp is one of my favorite devotionals of all time. In 52 short passages, Tripp explores the rich truth of Psalm 51. As he explains in the introduction, "Psalm 51 is about how God meets us in our moments of deepest failure and transforms us by his grace. It is about how broken sinners can be brutally honest with God and yet stand before him without fear."
This is a great little book that will take you to unexpected places in your spiritual walk.
You can pick it up at a great discount right now from Vyrso.com and read it in the free Vyrso app.
One of the most interesting passages contains a story from Tripp's ministry:
It was a wonderful opportunity. I was asked to participate in an open discussion about death and dying from a patient's perspective. The event was held at a local medical college. It was the first ministry situation I had ever been in where I had sat between a rabbi and two imams. My Jewish and Islamic colleagues were all very warm and articulate, but I had an unfair advantage: I came armed with the gospel. I carried something into the room that no one else had, and as the evening went on this message glistened with greater and greater beauty.
The men on either side of me were gentle and caring. They knew their faith well, but they had one distinct disadvantage: the only message they brought into the room was the message of the law. The only hope they could give was the hope that somehow, someway, a person could be obedient enough to be accepted into eternity with God. The more they spoke, the more beautiful the gospel looked.
The most significant moment of the evening came when we were asked about what we would say to a family of someone who had committed suicide. It was at this moment that the gospel shined the brightest. I said, "Suicide doesn't change the paradigm. Think with me: who of us could lie in our bed during the last hours of our life and look back and say to ourselves that we have been as good as a person could be? Wouldn't all of us look back and have regrets about things we have chosen, said, and done? None of us is able to commend ourselves to God on the basis of our performance. In this way, the person who has committed suicide and the person who hasn't are exactly the same. Both of them are completely dependent on the forgiveness of a God of grace, in order to have any hope for eternity."
This is a book you'll read again and again. Get it today and start exploring the mercy of God.


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Low back pain can have many causes. Check out the most common culprits.
Jun 27, 2017. Good posture during the day can alleviate lower back pain and. "Slide Show: Sleeping Positions That Reduce Back Pain – Mayo Clinic.
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Mayo Clinic Health Letter provides reliable, easy-to-understand, health and medical information. of arthritis. Rotator cuff injury — Steps for shoulder pain. The pain in your lower chest made deep breaths — and coughing — hard to tolerate.
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Back pain — Comprehensive overview covers causes, treatment, relief for this potentially disabling condition.
Nov 11, 2016. This chat focused on treatment options for chronic back pain, ways to measure. his internship, residency and fellowship at the Mayo Clinic in Rochester, Minnesota. Focal pain in the lower right region of your back could be.
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Ralph E. Gay, M.D., M.S., Mayo Clinic Associate Professor of PM&R, discusses clinical practice guidelines for low back pain; What are they for and do they work?
17.09.2011 · Numerous conditions can cause lower back and lower abdominal pain. According to FamilyDoctor.org, an information website produced by the.
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May 13, 2013. In a study of 52 sedentary patients with chronic lower back pain, Dr. Michal. According to the Mayo Clinic, USA, approximately 80% of all.
Examine the most common causes of lower back pain including muscle strain, herniated discs, degenerative disc disease, spinal stenosis and more.
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Antique Blue and White floral china Tourways flowblue Platter
Attributed to Brown Westmead Moore & Co antique Tourways flow blue platter circa 1860-1890
- 14.5 inch by 10.5 inch oval platter
- Flow Blue floral transfer Tourways pattern.
- Manufactured by Brown Westmead Moore & Co factory Staffordshire late 19th century
- Part of a large dinner set now sold
- Good condition with some surface marks and heat staining to base plate only.
We Also Recommend
Antique Samuel Alcock Carlton pattern Flo Blue and White China Platter c1840
Regular price £260.00 £260.00
Rare Antique Copeland late Spode Filigree Blue and White China Tureen c1850
Sale price £135.00 £135.00 Save £50
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Digital designer with 6+ years experience working in marketing and advertising.
What i do
– concepting
– wireframing
– branding and identity
– website + app design
– art direction
– print + publication
I'm proficient in
– figma
– sketch
– adobe ai, id, ps
– invision
– keynote
– microsoft office
Get in touch to talk about your next design project.
Hire me for:
These are freelancers I work with on bigger projects.
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text: Dominus salvum fac regem.鈥?[85] "Oh鈥攏o鈥攏o鈥攏o! Madame would not quarrel. She would not leave monsieur鈥擨 know it." The writer takes this opportunity to inform all those friends, in different parts of the country, who generously contributed for the redemption of these children, that they are at last free! "Good Lord! suppose I'd been laid out before I had a chance to spend a dollar!" he thought with horror. "All right," he agreed, nervously, then added to me, "and if you fellows see any one try to follow us鈥攜ou stop 'em. See?" 黄网站色视频免费_色www亚洲免费_天天综合网_色天天综合网视频网站 F茅licit茅 and her mother took refuge in an apartment lent them by a friend in a Carmelite convent in the rue Cassette, where they received the visits of different friends in the parloir. Amongst the most assiduous was the Baron d鈥橝ndlau, a friend of the late M. de Saint-Aubin, a man of sixty, very rich and of a distinguished family. He wished to marry F茅licit茅, who refused him, but so great were the advantages of such an alliance that her mother desired her to reconsider the matter. As she still declined, he turned his attentions to her mother, and married her at the end of a year and a half. Kennedy nodded, but without enthusiasm over the proposition. Rather it was an invitation to Doyle to go on.


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CEAPI president, Nuria Vilanova, presented the Congress in her recent tour of Latin America. / Photo: CEAPI
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The Consejo Empresarial Alianza por Iberoamerica (Ceapi) is preparing the celebration in Madrid from September 30 to October 2 of the III Ibero-American Congress for presidents o...
The appeal of the British ambassador in Madrid, Hugh Elliot, to try to find Lourdes Arnaiz, the person who helped him selflessly and generously when he was in a hurry in Burgos during his first trip to Spain in 1984, was immediately
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Posted at August 20th, 2013, Carmela Bella Parisi write about Creative Tiny Apartment Furnished with Compact Furniture to Save Space. People have some reason why they prefer living in apartment. Its strategic location which is near public facilities in central city leads people to choose apartment as their dwelling. In addition modern design of apartment provides simple a...Read More
Posted at August 4th, 2013, Carmela Bella Parisi share about Exquisite Zen Kitchen Decorating Ideas with Modern Appliances. To have a kitchen with the kitchen decorating ideas, like the Zen Kitchen Decorating Ideas is a very nice idea because that kind of decorating ideas will be able to change the appearance of the kitchen to be a lot more comfortable and a lot...Read More
Posted at April 8th, 2014, Carmela Bella Parisi write about Modern Home Extension Project in Amazing Appearance. You should see a modern home extension project by Loic Picquet Architects that show you an amazing home extension design. If you have a plan to renovate your home and build the extension room, then you can make it. Look at to the picture on...Read More
Posted at March 20th, 2014, Carmela Bella Parisi share about Pet Furniture Design: new wave Design. Well, there are so many new things that we can find in this modern space design era and one of them is this pet furniture design. You know, there was the time where pet is stay out of our house, but now time has change, now pet has special ...Read More
Posted at March 7th, 2014, Carmela Bella Parisi post about Exotic Resort Interior in Caribbean Sea. Designing a resort interior is obviously much more different with designing residential or office space interior design. Somehow, resort designs have more rules and guidelines due to their purpose of building. Every rules and guidelines are...Read More
Posted at March 9th, 2014, Carmela Bella Parisi write about Fascinating Chalet Design for Party People. Typical chalet design commonly comes with a traditional wooden material with a sloping roof and overhanging eaves. Chalet is a building located in Alpine region and wide spread in Switzerland. Originally, chalet was used as seasonal farms f...Read More
Posted at July 28th, 2013, Carmela Bella Parisi share about Excellent Modern Nightstand in Various Modern Gives Dramatic View. Bedroom is living space where we can take a rest cozily. Thus, comfort is important to arouse desire to sleep soundly. Look at this white themed bedroom which is equipped with Modern Nightstand. White bed is supplied with white padded bed h...Read More
Posted at December 23rd, 2013, Carmela Bella Parisi share about IKEA Solar Panel Product: One of the Best "Green" Energy Products. This IKEA solar panel product is indeed one of the leading "green" products in the world right now. Well, people right now consider sun as one of the most relevant alternative clean energy sources for the future. That is why people star...Read More
Posted at November 5th, 2013, Carmela Bella Parisi share about Interior Design Idea: the Uniqueness of Setting. Having a unique interior design idea is surely something that will make everybody happy in their home. You know, interior design is like the identity of the design. It is like the "face" of the design and which one does you prefer, the ...Read More
Posted at January 26th, 2014, Carmela Bella Parisi post about Classic Contemporary Interior Design for Home. Classic contemporary interior design is one of concepts that people always try to apply in their home, their office, or even their garage. This awesome design will bring a fascinating ambience so people can simply enjoy it when they enter t...Read More
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Spirotetramat (SPT) is a new tetronic acid derivative insecticide used to control scales and aphids; the potential for endocrine disruptor effects in fish could not be finalized with the available data. In this study, zebrafish were selected to assess the endocrine-disrupting effects. Significant decrease of plasma estradiol (E2), testosterone (T) and 11-ketotestosterone (11-KT) were observed in both male and female following the spirotetramat exposure; the vitellogenin (VTG) level in females significantly decreased. The expression of the hypothalamic-pituitary-gonad (HPG) axis genes fshr, lhr and esr1 showed significant increase in the gonads, which expression in males is higher than in females. In addition, the activities of capspase-3 and caspase-9 significantly decreased in both males and females liver, while the capspase-3 and caspase-9 were increased in male testis, the mRNA expression levels of genes expression related to the apoptosis pathway were also significantly altered after the spirotetramat exposure. Additionally, we found the parental zebrafish exposed to spirotetramat induced the development delay of its offspring. Above all, the adverse effects induced by spirotetramat suggesting that spirotetramat is a potential exogenous hazardous agent.
MicroRNA-132 (miR-132) has been shown to participate in many diseases. This study aimed to understand the correlation between the level of miR-132 and the severity of dementia post-ischemic stroke. An online tool (www.mirdb.org) was used to find the miR-132 binding site in acetylcholinesterase (ACHE) 3'-untranslated region (UTR), followed by a luciferase reporter assay to validate ACHE as a miR-132 target. A similar relationship between miR-132 and ACHE was also established in cerebrospinal fluid samples collected from human subjects. A negative correlation was established between ACHE and miR-132 by measuring the relative luciferase activity. Meanwhile, Western blot analysis and real-time polymerase chain reaction were also conducted to compare the levels of ACHE messenger RNA and protein between two groups (dementia positive, n = 26 and dementia negative, n = 26) or among cells treated with miR-132 mimics, ACHE small interfering RNA, and miR-132 inhibitors. As shown in the results, miR-132 can reduce the expression of ACHE. Further experiments were also carried out to study the effect of miR-132 and ACHE on cell viability and apoptosis, and the results demonstrated that miR-132 enhanced cell viability while suppressing apoptosis. In addition, ACHE reduced cell viability while promoting apoptosis. miR-132 targeted ACHE and suppressed its expression. Additionally, miR-132 and ACHE have been shown to affect the cell viability and apoptosis in the central nervous system.
The present study aims to provide anatomical evidence for clinical application of the medial sural artery perforator (MSAP) flap. The current study investigated the vascular anatomy of the flap, evaluated the postoperative appearance and function of the donor and recipient sites, and investigate the clinical value in reconstruction of oral cavity. Six lower limbs of Chinese adult cadavers were microsurgically dissected. The locations and courses of the medial sural artery perforators were identified and recorded, which provided an anatomical basis for clinical application. Then, 16 clinical cases employing this flap were evaluated, ranging from 3×4cm to 6×8cm, and were employed for defects in the oral cavity region. Sixteen clinical cases with intraoral soft tissue defects, which included four clinical cases with inner cheek defects, were successfully followed up for 10-47 months (24 months on average). The donor site function, contour of recipient site and oral function recovery were evaluated as acceptable or better in cases with intraoral soft tissue defect, which were further verifying the value of clinical application of MSAP in repairing oral cavity defects. Moreover, two typical clinical cases were described in detail. To conclude, the MSAP flap is a favorable choice for small- to medium-size defects based on minor donor site morbidity, satisfactory oral function recovery, perforator stability and adaptation of the pedicle for anastomosis in the oral cavity region.
Rhodococcus exhibits strong adaptability to environmental stressors and plays a crucial role in environmental bioremediation. However, seasonal changes in ambient temperature, especially rapid temperature drops exert an adverse effect on in situ bioremediation. In this paper, we studied the cell morphology and fatty acid composition of an aniline-degrading strain Rhodococcus sp. CNS16 at temperatures of 30⯰C, 20⯰C, and 10⯰C. At suboptimal temperatures, cell morphology of CNS16 changed from short rod-shaped to long rod or irregular shaped, and the proportion of unsaturated fatty acids was upregulated. Transcriptomic technologies were then utilized to gain detailed insights into the adaptive mechanisms of CNS16 subjected to suboptimal temperatures. The results showed that the number of gene responses was significantly higher at 10⯰C than that at 20⯰C. The inhibition of peptidoglycan synthase expression and up-regulation of Filamentous Temperature Sensitive as well as unsaturated fatty acid synthesis genes at suboptimal temperatures might be closely related to corresponding changes in cell morphology and fatty acids composition. Strain CNS16 showed loss of catalase and superoxide dismutase activity, and utilized thioredoxin-dependent thiol peroxidase to resist oxidative stress. The up-regulation of carotenoid and Vitamin B2 synthesis at 10⯰C might also be involved in the resistance to oxidative stress. Amino acid metabolism, coenzyme and vitamin metabolism, ABC transport, and energy metabolism are essential for peptidoglycan synthesis and regulation of cellular metabolism; therefore, synergistically resisting environmental stress. This study provides a mechanistic basis for the regulation of aniline degradation in Rhodococcus sp. CNS16 at low temperatures.
Objective: Poor sleep quality is common in nursing staff. This meta-analysis aimed to examine the pooled prevalence of poor sleep quality in nursing staff.Methods: A systematic search in PubMed, EMBASE, PsycINFO, and Web of Science databases was performed. Studies that reported sleep quality measured by the Pittsburgh Sleep Quality Index (PSQI) were synthesized using a random-effects model.Results: Fifty-three studies were analyzed. The pooled prevalence of poor sleep quality was 61.0% (95% CI: 55.8-66.1%). The pooled total PSQI score was 7.13 ± 0.18 (95% CI: 6.78-7.50). The pooled component scores were 1.47 ± 0.20 (95% CI of mean score: 1.08-1.85) in sleep latency, 0.91 ± 0.15 (95% CI of mean score: 0.61-1.21) in sleep duration, 1.59 ± 0.13 (95% CI of mean score: 1.35-1.84) in overall sleep disturbances, 0.33 ± 0.18 (95% CI of mean score: 0-0.67) in sleeping medication, 1.21 ± 1.20 (95% CI of mean score: 0.83-1.60) in daytime dysfunction, 1.39 ± 0.14 (95% CI of mean score: 1.11-1.67) in subjective sleep quality, and 0.66 ± 0.11 (95% CI of mean score: 0.44-0.87) in habitual sleep efficiency. Subgroup and meta-regression analyses found that PSQI cutoff values, mean age, body mass index (BMI), sample size, study quality, and work experience moderated the prevalence of poor sleep quality.Conclusions: Poor sleep quality appears to be common in nursing staff. Considering its negative impact on health, effective measures should be taken to improve poor sleep quality in this population. Longitudinal studies should be conducted to examine the contributing factors of nurses' poor sleep quality.
Exaggerated Ca2+ signaling might be one of primary causes of neural dysfunction in Alzheimer's disease (AD). And the intracellular Ca2+ overload has been closely associated with amyloid-ß (Aß)-induced endoplasmic reticulum (ER) stress and memory impairments in AD. Here we showed for the first time the neuroprotective effects of Xestospongin C (XeC), a reversible IP3 receptor antagonist, on the cognitive behaviors and pathology of APP/PS1 AD mice. Male APP/PS1-AD mice (nâ=â20) were injected intracerebroventricularly with XeC (3µmol) via Alzet osmotic pumps for four weeks, followed by cognition tests, Aß plaque examination, and ER stress-related protein measurement. The results showed that XeC pretreatment significantly improved the cognitive behavior of APP/PS1-AD mice, raising the spontaneous alteration accuracy in Y maze, decreasing the escape latency and increasing the target quadrant swimming time in Morris water maze; XeC pretreatment also reduced the number of Aß plaques and the overexpression of ER stress proteins 78 kDa glucose-regulated protein (GRP-78), caspase-12, and CAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) in the hippocampus of APP/PS1 mice. In addition, in vitro experiments showed that XeC effectively ameliorated Aß1 - 42-induced early neuronal apoptosis and intracellular Ca2+ overload in the primary hippocampal neurons. Taken together, IP3R-mediated Ca2+ disorder plays a key role in the cognitive deficits and pathological damages in AD mice. By targeting the IP3âR, XeC might be considered as a novel therapeutic strategy in AD.
Sulfur-containing materials are very attractive for the efficient decontamination of some heavy metals. However, the effective and irreversible removal of Cd2+, coupled with a high uptake efficiency, remains a great challenge due to the relatively low bond dissociation energy of CdS. Herein, we propose a new strategy to overcome this challenge, by the incorporation of Cd2+ into a stable ZnxCd1-xS solid solution, rather than into CdS. This can be realised through the adsorption of Cd2+ by ZnS nanoparticles, which have exhibited a Cd2+ uptake capacity of approximate 400â¯mgâ¯g-1. Through this adsorption mechanism, the Cd2+ concentration in a contaminated solution could effectively be reduced from 50â¯ppb to <3â¯ppb, a WHO limit acceptable for drinking water. In addition, ZnS continued to exhibit this noteworthy uptake capacity even in the presence of Cu2+, Pb2+, and Hg2+. ZnS displayed high chemical stability. Particles aged in air for 3 months still retained a> 80% uptake capacity for Cd2+, compared with only 9% uptake capacity for similarly-aged FeS particles. This work reveals a new mechanism for Cd2+ removal with ZnS and establishes a valuable starting point for further studies into the formation of solid solutions for hazardous heavy metal removal applications.
Through air inhalation, dust ingestion and dermal exposure, the indoor environment plays an important role in controlling human chemical exposure. Indoor emissions and chemistry can also have direct impacts on the quality of outdoor air. And so, it is important to have a strong fundamental knowledge of the chemical processes that occur in indoor environments. This review article summarizes our understanding of the indoor chemistry field. Using a molecular perspective, it addresses primarily the new advances that have occurred in the past decade or so and upon developments in our understanding of multiphase partitioning and reactions. A primary goal of the article is to contrast indoor chemistry to that which occurs outdoors, which we know to be a strongly gas-phase, oxidant-driven system in which substantial oxidative aging of gases and aerosol particles occurs. By contrast, indoor environments are dark, gas-phase oxidant concentrations are relatively low, and due to air exchange, only short times are available for reactive processing of gaseous and particle constituents. However, important gas-surface partitioning and reactive multiphase chemistry occur in the large surface reservoirs that prevail in all indoor environments. These interactions not only play a crucial role in controlling the composition of indoor surfaces but also the surrounding gases and aerosol particles, thus affecting human chemical exposure. There are rich research opportunities available if the advanced measurement and modeling tools of the outdoor atmospheric chemistry community continue to be brought indoors.
Topological data analysis (TDA) is a powerful method for reducing data dimensionality, mining underlying data relationships, and intuitively representing the data structure. The Mapper algorithm is one such tool that projects high-dimensional data to 1-dimensional space by using a filter function that is subsequently used to reconstruct the data topology relationships. However, domain context information and prior knowledge have not been considered in current TDA modeling frameworks. Here, we report the development and evaluation of a semisupervised topological analysis (STA) framework that incorporates discrete or continuously labeled data points and selects the most relevant filter functions accordingly. We validate the proposed STA framework with simulation data and then apply it to samples from Genotype-Tissue Expression data and ovarian cancer transcriptome datasets. The graphs generated by STA for these 2 datasets, based on gene expression profiles, are consistent with prior knowledge, thereby supporting the effectiveness of the proposed framework.
BACKGROUND: Incarceration of the gravid uterus is a rare obstetric disorder that contributes to pregnancy-related complications. To understand its clinical characteristics and managements, we have reviewed the etiology, risk factors, clinical characteristics and current treatments of an incarcerated gravid uterus based on 162 cases reported in the English language literature, including our patient. CASE PRESENTATION: A 25-year-old primigravida, with a history of lymphatic tuberculosis, infertility due to blocked fallopian tubes and received in vitro fertilization. The patient presented with urine retention and lower abdominal pain in the early second trimester. Uterine incarceration was diagnosed based on pelvic examination and abdominal ultrasound. A Foley catheter was placed and manual reposition was successful. No episode of retention was experienced after the further enlargement of the uterus and its ascent. A healthy infant was delivered vaginally on 38th week of pregnancy. CONCLUSIONS: Uterine incarceration due to pelvic adhesions is rare and, because of it non-specific clinical presentations, is often misdiagnosed. Abdominal ultrasound is instrumental for the diagnosis because it can directly image the disturbed uterine and pelvic anatomy. There are limited treatment options for uterine incarceration, but definitive diagnosis allows procedures to treat and to reduce severe complications of uterine incarceration.
Quantization aims to form new vectors or matrices with shared values close to the original. In recent years, the popularity of scalar quantization has been soaring as it has been found huge utilities in reducing the resource cost of neural networks. Popular clustering-based techniques suffers substantially from the problems of dependency on the seed, empty or out-of-the-range clusters, and high time complexity. To overcome the problems, scalar quantization is examined from a new perspective, namely sparse least square optimization. Specifically, several quantization algorithms based on l1 least square are proposed and implemented. In addition, similar schemes with l1+ l2 and l0 regularization are proposed. Furthermore, to compute quantization results with given amount of values/clusters, this paper proposes an iterative method and a clustering-based method, and both of them are built on sparse least square. The algorithms proposed are tested under three data scenarios and their computational performance, including information loss, time consumption and distribution of values of sparse vectors are compared. The paper offers a new perspective to probe the area of quantization, and the algorithms proposed are superior especially under bit-width reducing scenarios, when the required post-quantization resolution is not significantly lower than the original scalar.
Comprehensive genomic analyses of cancers have revealed substantial intrapatient molecular heterogeneities that may explain some instances of drug resistance and treatment failures. Examination of the clonal composition of an individual tumor and its evolution through disease progression and treatment may enable identification of precise therapeutic targets for drug design. Multi-region and single-cell sequencing are powerful tools that can be used to capture intratumor heterogeneity. Here, we present a database we've named CancerTracer (http://cailab.labshare.cn/cancertracer): a manually curated database designed to track and characterize the evolutionary trajectories of tumor growth in individual patients. We collected over 6000 tumor samples from 1548 patients corresponding to 45 different types of cancer. Patient-specific tumor phylogenetic trees were constructed based on somatic mutations or copy number alterations identified in multiple biopsies. Using the structured heterogeneity data, researchers can identify common driver events shared by all tumor regions, and the heterogeneous somatic events present in different regions of a tumor of interest. The database can also be used to investigate the phylogenetic relationships between primary and metastatic tumors. It is our hope that CancerTracer will significantly improve our understanding of the evolutionary histories of tumors, and may facilitate the identification of predictive biomarkers for personalized cancer therapies.
The novel commensal strain of Bacteroides fragilis HCK-B3 isolated from a healthy Chinese donor was discovered beneficial effects of attenuating lipopolysaccharides-induced inflammation. In order to contribute to the development of natural next-generation probiotic strains, the safety assessment was carried out with in vitro investigations of its morphology, potential virulence genes and antimicrobial resistance, and an in vivo acute toxicity study based on both healthy and immunosuppressed mice by cyclophosphamide injection. Consequently, the potential virulence genes in the genome of B. fragilis HCK-B3 have yet been identified as toxicity-associated. The absence of plasmids prevents the possibility of transferring antibiotic resistance features to other intestinal commensals. No intracorporal pathogenic properties were observed according to the body weight, hematological and liver parameters, cytokine secretions and tissue integrity. In addition, B. fragilis HCK-B3 performed alleviations on part of the side effects caused by the cyclophosphamide treatment. Thus, the novel strain of B. fragilis HCK-B3 was confirmed to be non-toxigenic and did not display adverse effects in both healthy and immune-deficient mice at a routinely applicable dose.
Glioblastoma is one of the most common primary tumor types of central nervous system (CNS) with high malignance and lethality. Although many treatment options are currently available, the therapy of brain cancers remains challenging because of blood-brain-barrier (BBB) which prevents most of the chemotherapeutics into the CNS. In this work, a poly(amidoamine) dendrimer-based carrier was fabricated and modified with angiopep-2 (Ang2) peptide that has been demonstrated to bind to low density lipoprotein receptor-relative protein-1 (LRP1) on the endothelial cells of BBB and could therefore induce BBB penetration of the carrier. To improve tumor-targeting effect towards the glioma sites, the dendrimer was simultaneously functionalized with an epidermal growth factor receptor (EGFR)-targeting peptide (EP-1) which was screened from a "one-bead one-compound" (OBOC) combinatorial library. EP-1 peptide was demonstrated to have high affinity and specificity to EGFR at both the molecular and cellular levels. The dual-targeting dendrimer exhibited outstanding BBB penetrability and glioma targeting efficiency both in vitro and in vivo, which strikingly enhanced the anti-gliomas effect of the drugs and prolonged the survival of gliomas-bearing mice. These results show the potential of the dual-targeting dendrimer-based carrier in the therapy of gliomas through enhancing BBB penetrability and tumor targeting.
Background: Extraction of periodontally compromised or strategically non-important teeth is often an integral part of non-surgical periodontal treatment (NSPT). This study evaluated the association between the status of adjacent teeth and the outcome of NSPT on molars. Methods: Charting data of patients with generalized chronic periodontitis receiving NSPT in 2012-2014 were included. The association between initial clinical parameters and significant clinical improvement, including the reductions of probing pocket depth (PPD) and clinical attachment loss (CAL), in molar teeth with severe periodontitis after NSPT was assessed by a generalized linear model and logistic regression. Results: ≥7 mm PPD and <2 mm gingival recession (REC) at the tooth level, and ≥7 mm PPD, ≥7 mm CAL and <2 mm REC at the site level, were associated with significant clinical improvement. Absence or extraction of an adjacent tooth achieved an additional 0.22-0.23 mm and 0.60-0.83 mm clinical improvement. Among the interproximal sites, ≥7 mm PPD, <2 mm REC, ≥7 mm CAL,
BACKGROUND: Clostridioides difficile is considered the main pathogen responsible for hospital-acquired infections. This prospective study determined the prevalence, molecular epidemiological characteristics, and risk factors for C. difficile infection (CDI) and C. difficile colonization (CDC) among patients in the intensive care unit (ICU) of a large-scale tertiary hospital in China, with the aim of providing strategies for efficient CDI and CDC prevention and control. METHODS: Stool samples were collected and anaerobically cultured for C. difficile detection. The identified isolates were examined for toxin genes and subjected to multilocus sequence typing. Patients were classified into CDI, CDC, and control groups, and their medical records were analyzed to determine the risk factors for CDI and CDC. RESULTS: Of the 800 patients included in the study, 33 (4.12%) and 25 (3.12%) were identified to have CDI and CDC, respectively. Associations with CDI were found for fever (OR = 13.993), metabolic disorder (OR = 7.972), and treatment with fluoroquinolone (OR = 42.696) or combined antibiotics (OR = 2.856). CDC patients were characterized by prolonged hospital stay (OR = 1.137), increased number of comorbidities (OR = 36.509), respiratory diseases (OR = 0.043), and treatment with vancomycin (OR = 18.168). Notably, treatment with metronidazole was found to be a protective factor in both groups (CDI: OR = 0.042; CDC: OR = 0.013). Eighteen sequence types (STs) were identified. In the CDI group, the isolated strains were predominantly toxin A and toxin B positive (A + B+) and the epidemic clone was genotype ST2. In the CDC group, the dominant strains were A + B+ and the epidemic clone was ST81. CONCLUSIONS: The prevalences of CDC and CDI in our ICU were relatively high, suggesting the importance of routine screening for acquisition of C. difficile. Future prevention and treatment strategies for CDC and CDI should consider hospital stay, enteral nutrition, underlying comorbidities, and use of combined antibiotics. Moreover, metronidazole may be a protective factor for both CDI and CDC, and could be used empirically.
Myeloid-derived growth factor (MYDGF) is a novel protein secreted by bone marrow cells that features important physiological functions. In recent years, MYDGF has gained considerable interest due to their extensive beneficial effect on cardiac repair and protects cardiomyocytes from cell death. However, its precise molecular mechanisms have not been well elucidated. The purpose of this study was to produce sufficient amount of biologically active recombinant human (rh) MYDGF more economically and effectively by using in vitro molecular cloning techniques to study its clinical application. The prokaryotic expression system of Escherichia coli was established for the preparation of rhMYDGF. Finally, a large amount of high biologically active and purified form of recombinant protein was obtained. Moreover, we investigated the potential mechanism of rhMYDGF-mediated proliferation and survival in human coronary artery endothelial cells (HCAECs). Mechanistically, the results suggested that MAPK/STAT3 and the cyclin D1 signalling pathways are indispensable for rhMYDGF-mediated HCAEC proliferation and survival. Therefore, this study successfully established a preparation protocol for biologically active rhMYDGF and it may be a most economical way to produce high-quality active rhMYDGF for future clinical application.
Increasing evidence revealed that circular RNAs (circRNAs) play important roles in tumor progression. In the present study, we explored the roles and underlying mechanisms of hsa_circ_0075341 in cervical cancer development. Our data showed that the expression of hsa_circ_0075341 was significantly upregulated and associated with larger tumor size, advanced FIGO stage, and lymph-node metastasis in cervical cancer patients. Hsa_circ_0075341 inhibition reduced cervical cancer cell proliferation and invasion in vitro. In mechanism, hsa_circ_0075341 negatively regulated miR-149-5p in cervical cancer progression. In addition, AURKA was confirmed as a direct target of miR-149-5p in cervical cancer and positively regulated by hsa_circ_0075341. Collectively, our data suggested that hsa_circ_0075341 promoted cervical cancer cell proliferation and invasion through regulating the miR-149-5p/AURKA axis, which provided a novel therapeutic target for cervical cancer treatment.
Irinotecan is one of the main chemotherapeutic agents for colorectal cancer (CRC). MicroRNA-200 (miR-200) has been reported to inhibit metastasis in cancer cells. Herein, pH-sensitive and peptide-modified liposomes and solid lipid nanoparticles (SLN) are designed for encapsulation of irinotecan and miR-200, respectively. These peptides include one cell-penetrating peptide, one ligand targeted to tumor neovasculature undergoing angiogenesis, and one mitochondria-targeting peptide. The peptide-modified nanoparticles are further coated with a pH-sensitive PEG-lipid derivative with an imine bond. These specially-designed nanoparticles exhibit pH-responsive release, internalization, and intracellular distribution in acidic pH of colon cancer HCT116 cells. These nanoparticles display low toxicity to blood and noncancerous intestinal cells. Delivery of miR-200 by SLN further increases the cytotoxicity of irinotecan-loaded liposomes against CRC cells by triggering apoptosis and suppressing RAS/ß-catenin/ZEB/multiple drug resistance (MDR) pathways. Using CRC-bearing mice, the in vivo results further indicate that irinotecan and miR-200 in pH-responsive targeting nanoparticles exhibit positive therapeutic outcomes by inhibiting colorectal tumor growth and reducing systemic toxicity. Overall, successful delivery of miR and chemotherapy by multifunctional nanoparticles may modulate ß-catenin/MDR/apoptosis/metastasis signaling pathways and induce programmed cancer cell death. Thus, these pH-responsive targeting nanoparticles may provide a potential regimen for effective treatment of colorectal cancer.
A concise total synthesis of (±)-conolidine, a potent nonopioid analgesic, in 19% overall yield is described here. A gold(I)-catalyzed Conia-ene reaction (Toste cyclization) and a Pictet-Spengler reaction served as key transformations for assembling the 1-azabicyclo[4.2.2]decane core and defining the geometry of the exocyclic double bond. The activation energies of formation of the vinyl-gold intermediates were calculated and revealed a silyl enol ether with an unprotected indole moiety as a suitable precursor for the Toste cyclization. This six-step synthesis did not involve any nonstrategic redox manipulations.


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November 12, 2009
Chris Dodd Is Getting His Butt Kicked In Latest Poll
It's a year away from election day and a lot can happen so don't get cocky but do take a moment to enjoy this.
Former Connecticut Congressman Rob Simmons has an early lead in the Republican primary race for the 2010 U.S. Senate contest and runs better than any other challenger against Sen. Christopher Dodd, topping the Democratic incumbent 49 - 38 percent, according to a Quinnipiac University poll released today.
Please don't tell me how Simmons is a RINO, I get it, I really do. Here's the thing...it's Connecticut. It's one of the bluest of the blue states. Having anyone from there with an R after their name is flat out thievery. If the only thing he does that I like is help to make Mitch McConnell Majority Leader, I'm happy.
Connecticut voters are, wait for it, liberals. They haven't accidentally been voting for the Chris Dodd, Joe Liebermann (yeah, he's a liberal 90% of the time) and Lowell Wickers of the world by accident. It's what they want. If we can give them a slightly less liberal Republican who will make Tom Coburn and Jeff Sessions committee chairs, sign me up.
Keep this in mind...it's Chris Dodd. I don't so much care who wins that seat as I do that this pompous, Friend of Angelo, fool is tossed out on his ass. I'd even be happy if he got booted in a primary.
The big question in this race is...Will LauraW hold her nose and endorse Simmons? The Nutmeg state holds its collective breath in anticipation!
And now that I've pissed a lot of you off, allow me to offer this as a second gift.
Another Quinnipiac poll shows Obama and Democrats dropping like stones in...Ohio.
For the first time, Republican Rob Portman is inching ahead of the two Democrats in the 2010 race for Ohios U.S. Senate seat, according to a Quinnipiac University poll released today. Also for the first time, Ohio voters disapprove 50 45 percent of the job President Barack Obama is doing, down from his 53 42 percent approval September 16 and 49 44 percent approval July 7.
Ohio is more or less the prototypical bellwether state.
If these trends hold (and that's a Gigantic if), next year is going to be very, very interesting.
The Connecticut poll story was via Major Garrett's Twitter feed.
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Updated now with the 2019 TV Commercials, 2018 the best TV ads. A website that covers brilliant advertising, funny commercials, Super Bowl Commercials.
Private developers are expressing a lot of interest in future commercial or residential projects. Short-term, a hotel on the Lee Highway corridor near the airport offers the best bet due to the.
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Explore some of the top songs that have appeared in various ads.. Television commercials often turn to classic rock and oldies songs as soundtracks for their pitch to make people of targeted. doubletree hotels.
Commercial Construction Loan Interest Rate This post will shed some light on commercial construction loans and demystify the lending process. Commercial Construction Loans and Lenders. The construction loan process begins when a developer submits a loan request with a lender. Construction or development lenders are almost always local community and regional banks.
· The best commercial water heaters will often come with a warranty. Most commercial water heaters hold between 75 and 100 gallons of ready-to.
Hammond Mayor Thomas McDermott Jr., said there's one new development he would like to see come out of the new casino project — a hotel at Horseshoe Hammond. ve long believed the town garage is not.
What is the difference between a consumer and a commercial or. Are all commercial displays the same, and how do you choose the best one for. plan for TVs to be used in hospitality applications like hotels and motels,
The girl in the Lenscrafters commercial with short dark hair is actress Meredith Forlenza. She has been in a few small-budget films, and seems to be best known for the Lenscrafters commercial..
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Business Loan Interest Rates 2017 Standard Chartered Bank business loan interest rate. The loan interest rate depends on various parameters. business loan interest rates 2017 | Stokesaviation – As of 03/18/2019, unsecured business loans rates range from 8.00% to 22.99% and will be based on the specific characteristics of your credit application including, but not limited to, evaluation of credit history and amount of credit requested.
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That number is prompting investors to call it the best hotel market in the country. the returns for hotel owners are not as high as they are for office developers. Commercial office rents in good.
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Saumya Goyal, BS 21, was already a future entrepreneur. She was sketching mechanical wing designs that she was planning to construct for flying.
Goyal is all the time enthusiastic about creating initiatives. As a senior adviser to AccelerateHer at UC Berkeley, a college membership that promotes enterprise spirit for ladies, it can maintain subsequent month the primary of its two new weekends. ends AccelerateHer. Goyal will likely be a part of the AccelerateHer staff welcoming UC Berkeley college students able to discover new startup concepts on November ninth, 10th and 16th. Students can apply right here.
"This club has grown significantly and now we are focused on these weekends," stated Goyal, who did a summer time internship at the Palo Alto-based TripActions start-up and is engaged on his personal startup. that can assist Indian girls villages in growth.
Focus on collaboration
The weekends are funded by a three-year grant awarded by Blackstone LaunchPad, a program created by the Blackstone Charitable Foundation and the Techstars Network to equip college students with extra instruments and assets to discover the thoughts. d & # 39; firm. (Earlier this month, Blackstone introduced a $ 5 million extension of the LaunchPad program, allocating $ 500,000 to every campus at the University of California).
Rajavi Mishra, president of AccelerateHer, stated the weekends would supply a possibility to strengthen collaboration inside the staff, which she typically discovered tough in hackathons, the place girls have been underrepresented and the place the emphasis was on coding.
"We wanted to host this because, in many hackathons, you have to know how to code and many of my friends do not know how to code. They can not apply, "stated Mishra, a significant laptop scholar. applies to Haas. "It's a platform for people who know how to code and have other skills to collaborate and create a product over the weekend."
Dip a toe within the water
Weekends additionally supply an immersive alternative for college students who don't have the time to have interaction in a protracted entrepreneurship course or an extended boot camp.
During every weekend, groups discover their concepts, uncover clients, construct prototypes and validate the enterprise alternative. The occasions, which is able to happen at Chou Hall and Cheit Hall, will lead to groups launching their startups.
All groups could have at least three and not more than 5 members, and two of them should establish as girls. Participants solely must provide you with an concept, stated Rhonda Shrader, government director of Berkeley Haas company program. Anyone who arrives with out a staff will likely be paired with different college students, she stated. The occasions characteristic 10 interactive start-up workshops, mentoring of main startup founders, community mixers, and starter toolkits.
Shrader stated that weekends have been a solution to get extra girls concerned, particularly those that concern hackathons and coding.
"It's a way for them to get their feet wet," she stated. "If we want more women founders, that's how we have to do it."
Mishra, who grew up in Delhi, India, is a fourth-generation entrepreneur. She started her journey in elementary faculty by creating web sites for her mates and small companies.
In Grade 9, she began a social enterprise referred to as Zariya, which has developed workshops and applications to assist youngster victims of violence in New Delhi. But she stated there was not a lot assist for startups in her space. "That's why I wanted to come to Berkeley and when I came here, I realized the support we had," she stated. "I can not be more grateful."
Mishra stated the group was enthusiastic concerning the college students and accepted extra purposes. The deadline to use is Thursday, October 31st.
AccelerateHer's publish plans immersive Haas start-up weekends showing for the primary time on Haas News | Berkeley Haas.


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Sequoyah Breakfast Club
Students who have read a book from the Sequoyah Master List for 2020 may sign up to attend. The club will meet one Friday morning a month until it's time to vote. Students must have read 3 books from the list in order to vote in the spring.
* Required
My Name
Your answer
Which book did you read? You can only log one book per meeting but you can read as many as you like.
The Assassination of Brangwain Spurge by M.T. Anderson and Eugene Yelchin
Sweep: The Story of a Girl and Her Monster by Jonathan Auxier
March Forward, Girl: From Young Warrior to Little Rock Nine by Melba Pattillo Beals
Ivy Aberdeen's Letter to the World by Ashley Herring Blake
The Benefits of Being an Octopus by Ann Braden
Marcus Vega Doesn't Speak Spanish by Pablo Cartaya
Like Vanessa by Tami Charles
The War Outside by Monica Hesse
Nowhere Boy by Katherine Marsh
The Flight of Swans by Sarah McGuire
Until Tomorrow, Mr. Marsworth by Sheila O'Connor
Boots on the Ground: America's War in Vietnam by Elizabeth Partridge
After the Shot Drops by Randy Ribay
Amal Unbound by Aisha Saeed
Front Desk by Kelly Yang
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155 East Market Street Suite 575 Indianapolis, IN 46204
Is this your listing? Update it now! | TestimonialsVisit Website
At Sallee Law, LLC, our legal team is committed to the best possible outcome of your criminal or family law matter. We practice exclusively in criminal law and family law, drawing on our many years of experience.
Over the past 10 years, Todd Sallee has obtained notable case results in diverse criminal cases ranging from DUI and drug crimes to sex offenses and violent crimes. He has also developed a niche as the "go-to" attorney for license cleanup and record expungement, enabling otherwise law-abiding citizens to move forward from a regrettable incident that threatens employment and other opportunities.
Attorneys, Criminal Attorneys, Dui and Dwi Attorneys, Traffic and Vehicle Attorneys
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Qualified RGI Registered Plumber required with Safe pass, for work in Cork City Experience essential. Successful candidate must be fully qualified with experience. Tools and transport required.
Please send your CV to firstname.lastname@example.com
For a full list of our jobs please visit www.clsrecruitment.ie
To apply for this job email your details to firstname.lastname@example.com