text:
193228 Staff engineer (Open)
About Our Group
The Customer Technical Support group will provide technical support on Seagate products to North China Cloud customers and business partners and acts as a technical resource within the Seagate organization.
The experienced CTS Engineer, as a partner to sales, will be part of the Seagate customer-facing team working on internal and external projects relating to Seagate's products and businesses.
About the Role You will :
Provide technical support on Seagate products to China Cloud customers and business partners and act as a technical resource within the Seagate organization
Act as the partner of Sales and will be part of the Seagate customer-facing team working on internal and external projects relating to Seagate's products and business
Provide product support on all aspects of performance and features of Seagate products
Provide product evaluation and qualification support, working with internal and external team members to determine appropriate products for evaluation
Perform administrative operations to support product evaluations and product performance
Provide onsite support for customers operations where required, and work to identify device failures and assure timely resolution of reported problems
Monitor product quality performance with assigned customers and regularly reporting integration performance
Provide failure verification support where required and issue failure analysis reports followed with corrective actions
Organize technical training for partners and customer as and when required
Provide training on a wide variety of technical subjects to managers and technical staff at customer sites
Maintain knowledge of the Seagate HDD / SSD product line and ensure the customers are kept informed of all the latest technical information related to the products within the assigned group
Maintain awareness of production issues at major customers and other situations that require support
Communicate recommendations for resolution internally
Bring back and translate major customer technical specific requirements to internal language for joint project setup.
Take the lead for project engagement progress and timeline management
About You
Good spoken and written communication skills
Stable work history and excellent track record
Good team player and able to work as part of a team
Your Experience Includes :
Relevant years of experience in IT Hardware R&D or Engineering related area (HDD / SSD, Server / Storage) or cloud industry is preferred
Experience as a project manager or core team leader is plus
Good knowledge of computer platforms, including HDD&SSD, operating systems, hardware, processors, memory, storage, etc
Good knowledge of cloud computing and cloud storage
Good ability to quickly assess and define technical problems and their causes and recommend solutions
Strong technical knowledge of storage interfaces : SAS, SATA, NVMe, PCIE, RAID, JBOD
Strong customer-relationship-management skills and report-writing
Location : Beijing
Seagate first entered the Chinese market in 1995, and in the more than 20 years that followed, has committed itself to remain at the forefront in the innovation and development in the country's storage industry.
With its strong technological knowledge and experience, Seagate has worked with many customers and business partners to help capture market opportunities both domestically and overseas.
Now the company operates four branch offices in Beijing, Shanghai, Shenzhen, Chengdu; an entity in Tianjin; a surveillance center and a data recovery center in Hangzhou.
Travel : 10%
Job Family : Engineering Professional


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Compare McKinsey & Company vs Appirio BETASee how Appirio vs. McKinsey & Company compare on employee ratings, job openings, CEO approval, business outlook and more.
Employee Ratings
What Employees Say
I have been working at McKinsey & Company full-time for more than 3 years
The benefits are unmatched. Colleagues are smart, helpful, & supportive. The work is interesting.
Work life balance is a challenge
I have been working at Appirio part-time for less than a year
I started working in the early spring of 2019 and love my job! With the Wipro influence, there are endless opportunities for Appirians across the organization. My manager has been very supportive and... is quick to get involve to support me in any challenging situations as they arise. I have no intentions of going elsewhere and would recommend my family and friends to work at Appirio.
The system migration from Google to Microsoft has been a challenge, with some hiccups and bumps along the road, but the end is in sight and Appirio ELT is quick to get involved to escalate as needed.
Advice to Management
Continue to support employees on the day to day challenges of the overall transition now that Appirio is a Wipro company.

subset: commoncrawl


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The remains of a caved-in cinder cone have created the beautiful cove in which this crescent-shaped beach is found. Detailed information about poverty and poor residents in Napili-Honokowai, HI. The Ritz-Carlton, Kapalua. People not drinking alcohol at all: This is a well shaded black sand beach protected by steep cliffs and tall trees.
On a nice day, most beaches are crowded with locals and tourists alike.
Swimming during winter is not advised due to high surf, but at other times of the year, excellent snorkeling can be found here. Its a place in your mind you revisit for calming, energy and inspiration. Work and jobs in Napili-Honokowai:
Castle Kamaole Sands Condominium Rentals.


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yaphit the orville Norm MacDonald actor actress photo Comedian
yaphit the orville
About yaphit the orville:
Saturday Night Live cast part from 1993 to 1998 who secured Weekend Update. He has showed up in various Adam Sandler films including Billy Madison and Grown Ups and facilitated the Sports Show with Norm Macdonald on Comedy Central in 2011.
Prior to Fame
He started his profession by performing in neighborhood parody clubs in Ottawa. He later begun his profession in excitement by composing for the hit show Roseanne.
Incidental data
He was broadly terminated from SNL in light of the fact that NBC West Coast Executive Don Ohlmeyer didn't think he was entertaining however many trust Ohlmeyer's fellowship with OJ Simpson, who was frequently ridiculed on Update, was the reason.
Family Life
He had a child named Dylan with Connie Macdonald, whom he was hitched to from 1988 until 1996. He has two siblings, Leslie and Neil Macdonald, who both progressed toward becoming columnists with the CBC.
Related With
He has showed up on The Drew Carey Show.
We realize that you constantly needed to know yaphit the orville as a Norm MacDonald . We realize that you are a major fan yaphit the orville and we found a Norm MacDonald genuine name for you. We endeavor to make the s on our site dependably state-of-the-art, when some lapses, we attempt to locate another one – particularly for you. We are extraordinary devotees of the whole TV arrangement and we are inspired by the job it plays in it Norm MacDonald as a character yaphit the orville. We trust that this arrangement will never end and we will look for quite a while Norm MacDonald on the screen of our TVs. Norm MacDonald played in a wide range of creations of which he is additionally known.
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Watch Charlie's Angels (2019) Online Free Official 123Netflixby meca-11770 | created - 4 weeks ago | updated - 1 day ago | Public
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A wealthy mystery man named Charlie runs a detective agency via a speakerphone and his personal assistant, John Bosley. His detectives are three beautiful women, who end up in a variety of difficult situations.
Stars: Kate Jackson, Farrah Fawcett, Jaclyn Smith, David Doyle
Votes: 9,492


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Hero police officer is sacked for stealing a kayak and paddles and trying to sell them on eBay
- Andrew Hamilton of Lincolnshire police was caught in an undercover sting
- He denied it at first but later admitted the thefts and lost his job
- As an officer, he was once commended for saving a man's life
- Now he faces an uncertain future and his family could lose their home
A hero police officer has been sacked for stealing a kayak and a set of paddles which he then tried to sell on eBay.
PC Andrew Hamilton was caught after Nottingham Kayak Club members spotted that one of their boats, which had gone missing in May, was for sale online.
They bid for the items in an undercover sting and confronted Hamilton, who had been awarded for bravery just months before, at his home.
At first the police officer lied that he had got the kayak from Scotland, before claiming he thought it had been thrown out.
But Hamilton admitted the allegations and was dismissed without notice after a police misconduct hearing at Lincolnshire Police headquarters yesterday.
PC Andrew Hamilton was once hailed a hero but has now lost his job
The hearing came after the officer, who served in Grantham, was convicted of two counts of theft between May 1 and July 9 when he appeared at Nottingham Magistrates Court on August 8.
Dismissing him, Chief Constable of Lincolnshire Police Neil Rhodes said: 'I am satisfied on the balance of probabilities the officer's conduct amounts to gross misconduct.
'Let me be clear I understand the impact on the officer will be massive.
'But there can be no place in the police service for an officer who demonstrated such unequivocally disingenuous behaviour.'
The disciplinary panel heard about the undercover sting mounted by by Nottingham Kayak Club.
Solicitor Matt Greene, representing Lincolnshire Police, said: 'A woman's daughter who attended the club noticed her kayak was missing.
'Her mother asked people round the club and was told a kayak matching her description was on eBay.
'The kayak was bid on by another member of the kayak club and was arranged to be collected from the home address of the seller.'
Hamilton, who was not present at the hearing, also stole a set of paddles which he sold for £142.
PC Andrew Hamilton (R) was given a bravery award by the chief constable of Lincolnshire police Neil Rhodes last year after saving the life of a man who had collapsed. But yesterday, Chief Constable Rhodes dismissed him for gross misconduct
Police Federation solicitor Craig Hewitt, who represented Hamilton, said: 'He says he's struggling to see a future.
'He and his family may lose their home and he accepts he will be dismissed from the force.
'He knows he let Lincolnshire Police down and can't forgive himself for what he has done.'
Hamilton received a commendation for bravery from Chief Constable Rhodes in November last year after saving the life of a driver who collapsed at the wheel.
He was praised for his quick thinking, bravery and dedication at a special awards ceremony.
Hamilton and PC Danielle Crompton were driving along the A46 dual carriageway when they noticed a man slumped at the wheel of a car doing 60mph in June last year.
The Audi was heading towards stationary traffic until PC Crompton accelerated and brought the police car to a halt before administering first aid on the collapsed driver.
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Cited 15 times in
B Cell-Intrinsic and-Extrinsic Regulation of Antibody Responses by PARP14,an Intracellular(ADP-Ribosyl)Transferase
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Aluminium Sulphate - You find here 28 suppliers from Germany Ukraine China Switzerland and Italy. Please obtain more information on spare parts, servicing, maintenance, Repair, repair or accessories directly from the registered companies.
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Aluminum Sulfate Anhydrous is an aluminum salt with immune adjuvant activity. This agent adsorbs and precipitates protein antigens in solution; the resulting precipitate improves vaccine immunogenicity by facilitating the slow release of antigen from the vaccine depot formed at the site of inoculation.
• Avoid contact with Aluminum sulfate. If there is a potential for contact, wear protective gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation.
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Aug 26, 2016· Aluminium Sulphate Manufacturing Process,Aluminium Sulphate Plant Mining Equipment Manufacturers Aluminum Sulfate, Learn about the various uses of aluminum Aluminum sulfate is a chemical …
Liquid aluminum sulfate is used in water treatment for the removal of phosphorous and water clarity. Alum removes suspended solids, total organic carbon, in raw water via charge neutralization and flocculation. Liquid aluminum sulfate can also be used in paper mills, dye manufacturing and synthetic catalyst production.
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Aluminum Sodium Sulfate is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered.Sulfate compounds are salts or esters of sulfuric acid formed by replacing one or both of the hydrogens with a metal.
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Aluminum Sulfate USP Aluminium Sulphate BP FCC ACS Manufacturers. CAS Number Aluminum sulfate anhydrous [10043-01-3], EINECS EC Number 233-135-0, HS Code 283322**, Molecular Weight 342.14, Chemical Formula: Al2(SO4)3
Aluminum Sulfate. Aluminum sulfate is known by a variety of names, among them cake alum and filter alum. This latter name refers to its use in water treatment. It is found in anhydrous form near volcanoes and in the waste dumps at coal mines. The molecular formula for cake alum is composed of two aluminum atoms and three sulfate (SO4) molecules.
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Zibo Boshan Win-Win Chemicals Co.,Ltd is one of the leading China aluminum sulfate manufacturers and suppliers with professional factory. Welcome to buy or wholesale aluminum sulfate, aluminium sulfate, paper manufacturing, waster water treatment, liquid aluminum sulfate products from us.


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Shop Batteries on EightCig
1x Captain PD270 234W Box Mod
WARNING: This product contains nicotine. Nicotine is an addictive chemical.
iJoy Captain PD270 Mod (Resin Version)
Log in for pricing
Size Chart
- Brand
- iJoy
- Weight:
- 12.00 Ounces
Building list of variants, Please wait...
iJoy Captain PD270 Mod (Resin Version)
This is the upgraded resin version of the Captain PD270 Mod.
The iJoy Captain PD270 is a high-performance box mod that features various battery compatibility and a fully equipped user control suite. An ergonomic design and front-faced OLED display gives the Captain PD270 a look of elegance and good taste.
This device is powered by dual 20700 batteries, or dual 18650 batteries with the included adapter (batteries not included).
The maximum power output of the Captain PD270 is 234W.
Quick Links:
Shop Batteries on EightCig
Shop All Tanks
Features and Specifications:
- Dimensions: 101.8mm x 57.9mm x 31mm
- Dual 20700 High-Amp Battery
- Optional Dual 18650 High-Amp Battery w/ Sleeve Adapter
- Maximum Wattage Ouput: 234W
- Temperature Control Range: 200-600F
- Ni200 Nickel , Titanium, and Stainless Steel Compatibility
- Vertical Display Layout
- Intuitive OLED Display
- Oversized Square Firing Mechanism
- Hinged Battery Door Cover
- Micro USB Port
- Spring-Loaded Stainless Steel 510 Connection
Package Includes:
1x Captain PD270 234W Box Mod
1x 18650 Adapter
1x Micro USB Cable
1x User Manual


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The recognition of carbapenemase-producing Enterobacteriaceae (CPE) isolates is a major laboratory challenge, and their inappropriate or delayed detection may have negative impacts on patient management and on the implementation of infection control measures. We describe here a matrix-assisted laser desorption ionization−time of flight (MALDI-TOF)-based method to detect carbapenemase activity in Enterobacteriaceae. After a 20-min incubation of the isolate with 0.5 mg/ml imipenem at 37°C, supernatants were analyzed by MALDI-TOF in order to identify peaks corresponding to imipenem (300 Da) and an imipenem metabolite (254 Da). A total of 223 strains, 77 CPE (OXA-48 variants, KPC, NDM, VIM, IMI, IMP, and NMC-A) and 146 non-CPE (cephalosporinases, extended-spectrum β-lactamases [ESBLs], and porin defects), were tested and used to calculate a ratio of imipenem hydrolysis: mass spectrometry [MS] ratio = metabolite/(imipenem + metabolite). An MS ratio cutoff was statistically determined to classify strains as carbapenemase producers (MS ratio of ≥0.82). We validated this method first by testing 30 of our 223 isolates (15 CPE and 15 non-CPE) 10 times to calculate an intraclass correlation coefficient (ICC of 0.98), showing the excellent repeatability of the method. Second, 43 strains (25 CPE and 18 non-CPE) different from the 223 strains used to calculate the ratio cutoff were used as external controls and blind tested. They yielded sensitivity and specificity of 100%. The total cost per test is <0.10 U.S. dollars (USD). This easy-to-perform assay is time-saving, cost-efficient, and highly reliable and might be used in any routine laboratory, given the availability of mass spectrometry, to detect CPE.
Gram-negative bacteria (GNB) and especially Enterobacteriaceae, Pseudomonas aeruginosa. and Acinetobacter baumannii have reemerged as major bacterial pathogens in resistance (1, 2). In these species, resistance may affect all major classes of antimicrobial agents with activity against Gram-negative bacteria (e.g., β-lactams, fluoroquinolones, and aminoglycosides). Enterobacteriaceae account for the majority of antibiotic-resistant bacteria and are rapidly increasing (3–5). In some cases, resistance extends to the entire repertoire of available therapeutic agents (extremely drug-resistant phenotypes), posing a formidable challenge to antimicrobial therapy and turning back the clock to the preantibiotic era (6).
Currently, β-lactamase-mediated resistance does not spare even the newest and most powerful β-lactams (i.e., carbapenems), whose activity is challenged by the class B metallo-β-lactamases (MBLs) and by class A and D serine carbapenemases (5). The dissemination of these enzymes among Enterobacteriaceae is a matter of concern since these pathogens are a major cause of nosocomial and also community-acquired infections, and carbapenems are major antibiotics in the treatment of these infections (6).
Appropriate antimicrobial therapy is of paramount importance for decreasing the mortality of patients with bloodstream infections (7, 8). As the presence of carbapenemases has been associated with clinical failure in patients with severe infections caused by Enterobacteriaceae isolates with high carbapenem MICs, interpreted as resistant (9), screening of carbapenemases is a matter of importance for appropriate treatment and also for the implementation of infection control measures to prevent or control outbreaks.
Several phenotypic methods have been proposed for carbapenemase routine detection. The combination disk test with various carbapenemase inhibitors is commercially available and easy to implement. It achieves good performance for detection and presumptive identification of most carbapenemase-producing Enterobacteriaceae (CPE) (but not OXA-48) but is time-consuming (18 h) (10). More interestingly, the biochemical Carba NP test has recently been developed and confirms carbapenemase production within 2 h with excellent sensitivity and specificity (11). Molecular identification of carbapenemases may also be performed, but it remains costly and requires substantial expertise.
Recently, matrix-assisted laser desorption ionization−time of flight (MALDI-TOF) mass spectrometry (MS) has been introduced in bacteriology laboratories and has been proved to be efficient compared with other conventional methods for bacterial identification (12). It also had a positive impact on patient clinical management in guiding empirical treatment (13, 14). In the context of increasing carbapenemase producers, it is of the utmost importance to detect carbapenemases to guide the most appropriate treatment. MALDI-TOF has recently been used to determine β-lactamase activity (15–17) but, to our knowledge, has not been used in a routine setting to detect carbapenemase activity in clinical isolates. We describe here a method for carbapenemase detection in Enterobacteriaceae from primary culture plates in less than 30 min using MALDI-TOF.
Bacterial strains and resistance detection.A total of 266 clinical enterobacterial isolates originating from several countries worldwide were used. Species were identified using MALDI-TOF mass spectrometry (MALDI Biotyper; Bruker Daltonics, France). Imipenem, ertapenem, and meropenem MICs were determined by Etests (bioMérieux, La Balme-les-Grottes, France) and were interpreted using the EUCAST 2014 guidelines (18). CPE isolates (n = 102) were characterized by carbapenem hydrolysis (Carba NP test and/or UV spectrophotometry) (19) and by PCR and sequencing. For non-CPE strains (n = 164), the presence of extended-spectrum β-lactamases (ESBLs) was determined by a double-disk synergy test between an expanded-spectrum cephalosporin and clavulanic acid. For some isolates, the type of ESBL was determined by PCR and sequencing. The presence of cephalosporinases was shown by use of the ESBL + AmpC screen kit (ROSCO Diagnostica, Taastrup, Denmark) or cloxacillin-containing agar plates (bioMérieux).
A total of 223 isolates of the 266 isolates (77 CPE and 146 non-CPE) were used to calculate a cutoff ratio. The 77 CPE strains included Klebsiella pneumoniae (n = 41), Escherichia coli (n = 18), Enterobacter cloacae (n = 9), Klebsiella oxytoca (n = 3), Citrobacter freundii (n = 3), Enterobacter asburiae (n = 2), and Raoultella planticola (n = 1). The resistance determinants present in these isolates were 48 OXA-48, 2 OXA-204, 1 OXA-181, 1 OXA-244, 8 KPC, 7 NDM, 4 VIM, 3 IMI, 2 IMP, and 1 NMC-A. The 146 non-CPE isolates comprised 66 E. coli, 34 E. cloacae, 14 K. pneumoniae, 9 C. freundii, 6 E. aerogenes, 4 Morganella morganii, 4 Proteus mirabilis, 3 K. oxytoca, 2 Citrobacter koseri, 1 E. asburiae, 1 Hafnia alvei, 1 Providencia stuartii, and 1 Serratia marcescens. Among these 146 non-CPE isolates, 103 produced a cephalosporinase, 24 produced an ESBL, 10 produced a cephalosporinase plus an ESBL, and 9 were porin deficient, as revealed by resistance to moxalactam, which is an excellent antibiotic marker for impermeability testing on a disk diffusion antibiogram, and by carbapenem resistance in the absence of carbapenem hydrolysis. The remaining 43 isolates (25 CPE and 18 non-CPE) were blind tested. They were 10 K. pneumoniae, 13 E. coli, 1 S. marcescens, and 1 E. cloacae. Resistance mechanisms consisted of 9 OXA-48, 9 KPC, 5 NDM, and 2 OXA-181. Noncarbapenemase producers were composed of 12 cephalosporinases, 4 cephalosporinases plus ESBLs, 1 porin defect, and 1 ESBL. There were 12 E. cloacae, 2 C. freundii, 1 E. aerogenes, 1 E. coli, 1 K. oxytoca, and 1 K. pneumoniae. K. pneumoniae YC-producing KPC-2 and K. pneumoniae CIP53153 (wild-type resistance phenotype) were used as positive and negative controls, respectively, to validate the MALDI-TOF assay (20).
MALDI-TOF mass spectrometry analysis of imipenem hydrolysis.Commercially available imipenem containing cilastatin (Hospira, Meudon la Forêt, France) was diluted in molecular biology-grade water (Eurobio, Courtaboeuf, France). The imipenem solution (50 mg/ml) was stored at −80°C for 1 month in 100-μl aliquots. Imipenem was used at a final concentration of 0.5 mg/ml according to Sparbier et al. (21). For each experiment, two controls (CPE/non-CPE) were tested to validate the assay.
Cultures of the tested strains were incubated overnight on Mueller-Hinton (MH) agar (bioMérieux, La Balme-les-Grottes, France) at 37°C. A 1-μl loop-sized amount of bacteria was suspended in 20 μl of 0.5 mg/ml imipenem solution, incubated 20 min at 37°C, and centrifuged for 1 min at 14,000 × g. One microliter of the clear supernatant was spotted onto an MSP 96 target polished steel plate (Bruker Daltonics, Wissembourg, France) and allowed to dry at room temperature, before 1 μl of matrix (α-cyano-4-hydroxycinnamic acid [HCCA]; Bruker Daltonics) was overlaid onto each target spot. Mass spectra were acquired using a Microflex LT mass spectrometer and flexControl software v3.3 (Bruker Daltonics) operating in positive linear ion mode between 100 and 1,000 Da. The parameters were set as follows: ion source 1, 19 kV; ion source 2, 16.3 kV; lens, 7 kV; pulsed ion extraction, 0 ns; detector gain, 3.3×; electronic gain, enhanced; mode, low range; mass range selection, 80 to 1,120 Da; laser frequency, 60 Hz; digitizer trigger level, 2,500 mV; laser attenuator, 25%; and laser range, 30%. A total of 240 shots were acquired in one position for one spectrum.
Internal calibration of the MALDI-TOF mass spectrometer.Peaks of HCCA, 2HCCA, bradykinin, and angiotensin II (peptide calibration standard II; Bruker Daltonics) were used as internal calibration of the mass spectrometer.
Spectrum analysis.Spectra were analyzed by FlexAnalysis software v3.3 (Bruker Daltonics). They were smoothed, and the baseline was subtracted. Peaks of imipenem (C12H17N3O4S) (300 ± 0.2 Da m/z) and its only known metabolite (C11H17N3O2S) (254 ± 0.1 Da m/z) were manually labeled and their intensities noted. MS ratios of intensities, metabolite/(metabolite + imipenem) [M/(M + I)], were calculated for the 223 cutoff strains to establish a ratio threshold between CPE and non-CPE isolates. Strains were classified as carbapenemase producers when this ratio was superior or equal to the cutoff.
Statistical analysis of carbapenemase activity and interpretation.SPSS v.20 (IBM Inc., New York, NY, USA) was used for all statistical analyses. Repeatability was evaluated using a subset of 30 isolates (15 CPE and 15 non CPE) that were tested 10 times each. All types of carbapenemases were tested: 3 OXA-48, 3 NDM, 3 KPC, 3 VIM, 2 IMP, and 1 OXA-181. Noncarbapenemase-producing strains were randomly chosen: 11 cephalosporinases, 3 ESBLs, and 1 cephalosporinase plus ESBL. First, among these 30 isolates, the mean and standard deviation (SD) were calculated (22). Second, the intraclass correlation coefficient (ICC) and its 95% confidence interval (95% CI), used as an absolute reliability index, were calculated by one-way random analysis of variance (ANOVA) (23).
A receiver operating characteristic (ROC) curve analysis was used to determine the optimal cutoff point (24). The area under the curve (AUC) and its 95% CI were estimated by a nonparametric method, and the optimal cutoff point was defined by the Youden index (25). Because two epidemiological patterns exist in the world, one with a higher incidence (India, United States, Greece, and others) and one with a lower incidence of carbapenemase (Northern Europe), secondary cutoffs in the ROC curve were defined: one with 100% sensitivity and one with 100% specificity.
The ratio-based model was validated: (i) for the internal validation, all of the 266 strains were used and the 0.632+ bootstrapping method of cross-validation enabled calculation of the coefficient of determination (R2) of the model (26); (ii) for the external validation, the results of 43 well-characterized isolates and blind tested using MS ratio interpretation were compared by the χ2 test (23) to molecular biology results. Identifications and resistance mechanisms were obtained only after MALDI-TOF hydrolysis testing was performed. The model was separately verified for the OXA-48-like carbapenemases and for the other carbapenemases.
Comparison between MS ratio model and meropenem MICs.The meropenem MICs of the 266 isolates were determined using the EUCAST 2014 guidelines and interpretative criteria. Sensitivities and specificities were estimated for the screening cutoff MIC of >0.12 mg/liter, corresponding to the extended common object file format (ECOFF) (27), and for the optimal MS ratio cutoff.
Reproducibility and determination of the cutoff ratio.The 1-μl loop-full-of-bacteria technique has previously been used for other biochemical tests such as the Carba NP test (11). In order to test its reproducibility with the MALTI-TOF CPE detection assay, 30 bacteria were tested several times. No differences in the mass spectra were observed, suggesting that the amount of bacteria is similar for each test. In order to verify the stability of imipenem preparations, 20 isolates (10 CPE and 10 non-CPE) were tested with imipenem that was freshly prepared on the day of testing and with imipenem that was stored for 1 month at −80°C. No significant differences were observed between the spectra of freshly prepared imipenem and those of imipenem stored for 1 month at −80°C for all the 20 isolates tested (data not shown). These results suggest that imipenem preparations are stable at least for 1 month at −80°C. Finally, no alterations in the imipenem spectra were observed after the 20 min of incubation without a β-lactamase. For all of the non-CPE isolates, spectra contained the molecular peak of imipenem at 300 Da and a minor peak at 254 Da corresponding to the metabolite. For CPE isolates, spectra revealed the increase in the metabolite peak at 254 Da along with a disappearance or a decrease in the peak of imipenem (Fig. 1). The MS ratio M/(M + I) of CPE strains ranged from 0.68 to 1.00. The MS ratio of non-CPE strains ranged from 0 to 0.78. The Youden index provided an optimal cutoff at 0.82, which is identical to the maximal specificity cutoff. The maximal sensitivity cutoff is at 0.67. All non-CPE strains had a ratio of <0.82. All but one CPE isolate had a ratio of >0.82, and one OXA-204-producing isolate had an MS ratio (r = 0.68) less than the calculated cutoff.
Validation of the model.Forty-three isolates (Table 1) were blind tested using the calculated cutoff (r = 0.82) for external validation. All isolates were correctly classified. The 25 CPE isolates presented a ratio between 0.83 and 1.0 and the 18 non-CPE isolates had a ratio between 0.05 and 0.34. With use of external validation strains, the sensitivity and the specificity of this imipenem hydrolysis test were 100%. For the hydrolysis method with the whole 266 strains, sensitivity was 99% and specificity was 100%.
The model's ability to discriminate between the CPE and non-CPE isolates, using AUC values in the ROC curve analysis, showed an outstanding value of 1 (95% CI, 0.99 to 1) (Fig. 2). The internal and the external validations showed R2 values of 0.91 and 1, respectively. The repeatability also gave a consistent ICC of 0.98.
Susceptibility testing.Carbapenem MICs are summarized in Tables 1, 2, and 3. With the recommended meropenem screening cutoffs in the EUCAST 2014 guidelines (MIC of >0.12 μg/ml) corresponding to the ECOFF (27), 99% (101/102) of the CPE and 30% (49/164) of the non-CPE were classified as potential CPE. One IMP-8-producing K. pneumoniae (meropenem MIC of 0.094 μg/ml) would have been considered a non-CPE with the EUCAST screening cutoff but had an MS ratio of 0.95. Among the 49 non-CPE isolates considered by the EUCAST screening cutoff to be possible carbapenemase producers, all isolates presented a negative MS ratio (r of <0.82). The only strain (OXA-204-producing K. pneumoniae) not detected as a CPE by the MS assay had a meropenem MIC of 0.125 μg/ml and was hence correctly suspected as a CPE using the EUCAST screening cutoff. The sensitivity and specificity of the EUCAST meropenem screening cutoff were 99% and 59%, respectively.
As dissemination of CPE is drastically increasing worldwide, an urgent need for rapid identification methods has emerged. The MALDI-TOF technique is becoming the method of choice for bacterial identification due to its rapid and reliable results, and, as a result, MALDI-TOF spectrometers are rapidly deployed in microbiology laboratories worldwide. In our study, we have successfully used the MALDI-TOF technique to rapidly detect carbapenemase activity in enterobacterial isolates, irrespective of the carbapenemase gene present. We tested >250 isolates, corresponding to a large variety of resistance mechanisms (different carbapenemases, ESBLs, cephalosporinases, porin defects, and combinations of mechanisms) among enterobacterial species. Using a ratio cutoff of 0.82, we found this assay reliable (99% sensitivity with only one false-negative result [one OXA-204] and 100% specificity) and fast and easy to set up on a daily basis in a laboratory routine.
MALDI-TOF has recently been used to detect β-lactamases, ESBLs, and particularly carbapenemases (15–17, 28, 29). In these approaches, the action of the β-lactamases was monitored by the analysis of antibiotics and their degradation products. We have observed in CPE a peak of 254 Da corresponding to an imipenem metabolite, described by Kempf et al. (30) and associated with a strong reduction and even absence of the imipenem peak of 300 Da (Fig. 1D, E, and F). For non-CPE, the imipenem peak (300 Da) was always present, but for some isolates, the 254-Da metabolite peak could also be observed (Fig. 1B and C), suggesting that the presence of this peak (254 Da) itself was not sufficient to categorize a strain as a carbapenemase producer. This leads to use of the MS ratio to reproducibly discriminate carbapenemase from noncarbapenemase producers.
The repeatability of this approach yielded an ICC value of 0.98, which is high enough to allow single testing of the strains. On the other hand, the validity of the MS ratio model is confirmed by the sensitivity and specificity of 100% for the blind-tested isolates and the robustness of the test as assessed by the R2 of the internal validation that is >0.90. These performances are consistent, considering that it is a blind test of a panel of clinical isolates compared with the gold standard that is PCR and sequencing. The only misclassified isolate was an OXA-204-producing K. pneumoniae. OXA-204 is known to be a weak carbapenem-hydrolyzing enzyme, and its expression is likely at the limit of detection (11).
MALDI-TOF MS has recently been shown to be a reliable method for KPC and NDM detection in Enterobacteriaceae with high sensitivity and specificity (15, 16, 30–35). Only one study investigated 6 OXA-48 producers (33). OXA-48, the most prevalent carbapenemase found in Enterobacteriaceae in France (75.4%) (36), is one of the most difficult to detect in routine settings using phenotypic methods. Our assay classified correctly all of the 57 OXA-48 producers tested. Furthermore, despite low carbapenem MICs, hydrolysis by OXA-48 was important: 43% of our strains had an MS ratio of 1.00, corresponding to a total degradation of imipenem in 20 min and suggesting that our test can be used for early detection of the most important carbapenemases in various epidemiological situations. Carbapenemase detection was, until recently, based on the analysis of susceptibility testing results. According to the EUCAST 2014 guidelines, the meropenem MIC seems to have the best sensitivity and specificity to detect carbapenemases compared to imipenem and ertapenem (37, 38). Interestingly, one CPE (IMP-8-producing K. pneumoniae) which had a meropenem MIC under the EUCAST screening cutoff was correctly identified as a carbapenemase producer with a positive MS ratio (r = 0.95). In parallel, none of the non-CPE with meropenem MICs higher than the EUCAST screening cutoff had a positive MS ratio (r = 0 to 0.66). Our assay, combining the 223 strains used for cutoff determination and the 43 external validation strains (sensitivity of 99%; specificity of 100%), performed better than the EUCAST screening cutoff (sensitivity of 99%; specificity of 59%). Unlike EUCAST, for which the meropenem screening cutoffs may vary depending on the prevalence of OXA-48 producers in the country, here only one MS cutoff was used.
As detection of CPE has become a major health issue, numerous diagnostic confirmation tests have been developed. Phenotypic methods such as the modified Hodge test (MHT) is not recommended anymore by the EUCAST 2014 guidelines (27) due to frequent false-positive and false-negative results (37, 39), and the combined disk test method, which is well validated and commercially available, is still lacking an inhibitor for class D enzymes (40, 41).
A rapid biochemical test, the Carba NP test, gave excellent results for a large variety of carbapenemases, including many OXA-48 (11, 42). In one publication, the Carba NP test experienced lower sensitivity with mucoid isolates and for some Enterobacteriaceae producing OXA-48 (43), but others showed 100% sensitivity and specificity (11, 42, 44). Among the 23 OXA-48-like isolates tested for the internal validation, 16 were negative or invalid with the Carba NP test (P. Bogaerts, personal communication). These 16 isolates (except one OXA-204 producer) were correctly classified by our test. UV spectrophotometry, which is considered to be the reference method for carbapenemase detection, has been evaluated and yielded a sensitivity of 100% and specificity ranging from 98.5% to 100% (11, 19), but this technique requires technical expertise, is time-consuming, and thus is not suitable for routine use.
Our MALDI-TOF CPE detection assay was performed in less than 30 min, including solution preparation, incubation, centrifugation, spotting, MALDI-TOF analysis, and interpretation. The 1-min centrifugation step is initiated just before spotting on the steel plate and thus does not delay significantly the workflow. To our knowledge, it is the fastest assay to detect carbapenemase activity. This speed is a critical point for patient management at the hospital to prevent CPE spread. Phenotypic detection methods (modified Hodge test, combined disk tests, selective agar, etc.) are based on cultures that require at least 18 to 24 h of incubation. In the literature, most assays based on mass spectrometry need 1 h to 4 h of incubation (15, 16, 21, 30–35, 45). The Carba NP test requires 2 h, especially for OXA-48 producers (42) and visual interpretation, which can be subjective. With the MALDI-TOF CPE detection assay, interpretation is computer assisted, thus allowing very little error in interpretation. Finally, this assay is easily scaled up in the sense that up to 48 or 96 samples can be processed at once on the mass spectrophotometer.
The choice of imipenem was dictated by the fact that masses (m/z) of the nondegraded form (300 Da) and its metabolite (254 Da) were distinct from that of the matrix HCCA (380 Da) (21, 30, 31). Hence, meropenem had an overlapping peak between the meropenem molecular peak (384 Da) and the HCCA peak (380 Da) (16, 30). Furthermore, there are only two peaks of interest for imipenem compared to meropenem and ertapenem (2 to 6 molecular peaks and 1 to 7 metabolite peaks) (15, 16, 31–35). This enables an easy MS ratio [M/(M + I)] interpretation. Furthermore, in the very near future, it will be possible to automatically calculate the ratio with the development of a software tool. Wang et al. used ClinProTools software to automatically label peaks and classify strains as CPE or non-CPE (35), while Hrabák et al. and Hoyos-Mallecot et al. used a special Flex analysis 3.0 software to detect peaks (16, 32). These software programs allow nonsubjective peak labeling. It is then possible to improve our method by developing a software tool for an automated interpretation of data.
If molecular methods are still the gold standard for accurate identification of carbapenemases, most of the time they require two steps: PCR for detection and sequencing for variant determination. They have excellent specificities and sensitivities and require <6 h to get a result but are expensive and require a trained microbiologist for interpretation. They can detect not only the presence of known carbapenemase genes but also whether they are expressed, unlike phenotypic assays (46), and even when the gene is detected, like OXA-48 variants such as OXA-163, this does not necessarily mean the presence of a carbapenemase. Compared to the molecular method, MS assays save costs, provided that laboratories have a mass spectrometer, which is very likely to occur in the near future, since MALDI-TOF is becoming the gold standard method for bacterial identification. The cost per test of our assay (including standard, matrix, and imipenem) is <0.10 U.S. dollars (USD).
Our protocol and its reproducibility need to be evaluated in other laboratories and also with different culture media since here only MH medium was evaluated. Other media such as chromogenic selective or Drigalski plates need to be evaluated. Finally, a future evaluation with β-lactamase inhibitors may directly indicate the carbapenemase type present.
Our study shows CPE detection in a routine setting in less than 30 min using MALDI-TOF technology. In consideration of our 266 tested isolates, our assay resulted in 99% sensitivity and 100% specificity on a large variety of Enterobacteriaceae expressing the most clinically relevant carbapenemases such as OXA-48, NDM, and KPC. It is an easy and cost-effective assay, which could be used in real time in the flow of routine lab work, which is of the utmost importance to prevent outbreaks and their consequences and to treat patients appropriately.
We gratefully acknowledge Katrin Sparbier and Peio Mogabure for their help and also Quentin Lasserre, who helped us to correct the language.
This work was partially funded by grants from the Université Paris Sud, France, and by a grant from the European Community (MAGIC-BULLET contract, FP7/HEALTH-F3-2012-278232). T.N. and G.C. are members of the Laboratory of Excellence LERMIT supported by a grant from ANR (ANR-10-LABX-33).
- Received 8 December 2014.
- Returned for modification 31 December 2014.
- Accepted 19 April 2015.
- Accepted manuscript posted online 29 April 2015.
- Copyright © 2015, American Society for Microbiology. All Rights Reserved.


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Zygor's Leveling Guide for The Elder Scrolls Online (PC Version) is an in-game, software based, strategy guide that will show you the quickest way to level your characters from 1-50. You can view and use the guide directly inside the game without having to print out anything or view the guide in a browser. This also means that our guides are dynamic and can track your progress in realtime.
The closed beta for Blizzard's upcoming World of Warcraft vanilla server option launched on May 15th, and Blizzard has now listed some of the apparent issues that the development team is aware of, including class and combat related issues alongside missing textures and more. Blizzard mentions that this list is not a complete depiction of what they're aware of, but a sampling of issues they believe players may encounter on regular basis.
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"International trade fair for demanding consumer culture"
Gustav event will display products like finished and unfinished pine furniture, handmade crafts, toys, home decor, handmade jewellery, cleaning products, clothing, homemade jams, jellies and cookies etc.
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Participants1000 - 5000
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19 - 20 Oct 2019
20 - 21 Oct 2018View More
27 - 29 Oct 2017
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Dornbirn Messe GmbH Austria11 events listed
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Arsenovic Nikola
Vlasnik I Radnik at Antikvarnica ArsenovicBelgrade, United States
iyad.alzaroAmman, Jordan
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Ceo at Honey InternationalWazirabad, Pakistan
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Manager at Akram Al - Bastanji FoundationMadaba, Jordan
Raman kumar
Managing Director at foods private limitedPhagwara, India
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Gustav will exhibit all types of decorative products and services including bath and building materials, office, decorative, electronics, garden, set table, crafts, home & garden, home textiles, classic, kitchen, light, literature, mechanics, furniture, mobility, fashion, jewelry, sports & games, watches, tools and so on.
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Messe GmbH Dornbirn
Messepl. 1, 6854 Dornbirn
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Businesshotel Valerianfrom EUR 125
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I would not recommend this company for the following reasons:1. Original appointment was very specific to them on what was needed and to take photos for 3 apartment unit plumbing fixture repairs. One unit had a bathroom tub/shower backup.2. No photos taken, 3 trips later and only 1 unit completed to satisfaction. (Backup) 3. Other faucets unable to find on line with their suppliers and repair 4. Had to find another plumbing company to complete the jobs. 5. Invoicing had to be redone as not in detail of job address for tax purposes 6. Bad communication throughout the project process with their internal customer service. Their technician and project manager ordering parts. 7. For the back up. Did not bring out correct snake on both trips and had to replace lines as too small to break through backup. Costing over $800 for 3 trips just to complete that situation out. 8. Ordered the wrong parts when 2nd trip out since no photos taken to confirm what was needed. Very dissatisfied and will never ask them to work in any of our rental properties again.
I hired this person because he was listed on Angie's List. This man claimed he took and passed his contractor's license test after he signed me up for a project (Feb.) that included fixing cracks, painting, repairing a gate, installing a screen door, etc. He said he would charge me the original "handyman" prices. He postponed the start date, brought one worker who fixed a few cracks, repainted the gate terribly, but ruined a dining room ceiling when his worker used silicone in a tube instead of the expansion tape, spray ceiling covering, and paint I had purchased saying this silicone was "better". Then they said they would have to paint the whole ceiling and charge extra. They left holes in the walls and did a sloppy paint job in several places. I just paid them to get them out of my home as I felt intimidated as a senior citizen who is handicapped. I will try to have the main guy come back when I let him know what I need redone. Don't know if he will come back without charging me more.
I've seen this done many years ago by a guy who did all sorts of jobs where I lived. My dad caught him painting his boss's roof and he was watering down the paint. We've had a hard time trying to get a painter for our house. We've had a guy that had been remmended by a neighbor and he hasn't showed up to paint for 2 weeks. I want to call him and my husband says no. I'm 69 years old and I'm about ready to go and paint our 2 porches, I've painted all my life and all the inside of our home. Maybe that's the way it should be with everyone that can paint pretty good.
In this Nov. 30, 2000, file photo, former pro wrestler Bruno Sammartino, 65, poses with a painting of him in his pro wrestling prime weighing 275 pounds in 1965 at age 35, in his Pittsburgh home. Bruno Sammartino, professional wrestling's "Living Legend" and one of its longest-reigning champions, has died. Sammartino was 82. Family friend and former wrestling announcer Christoper Crusie said Sammartino died Wednesday morning, April 18, 2018, and had been hospitalized for two months. Gene J. Puskar, AP
In this Aug. 19, 2005, file photo, Seattle Storm coach Anne Donovan, right, smiles as she is handed the game ball by team official Karen Bryant following the Storm's victory over the Minnesota Lyn in Seattle. The victory gave Donovan her 100th career WNBA victory as a coach, the first woman to reach that plateau. Donovan died on June 13, 2018, of heart failure. She was 56. Donovan's family confirmed the death in a statement. Elaine Thompson, AP
I hired this person because he was listed on Angie's List. This man claimed he took and passed his contractor's license test after he signed me up for a project (Feb.) that included fixing cracks, painting, repairing a gate, installing a screen door, etc. He said he would charge me the original "handyman" prices. He postponed the start date, brought one worker who fixed a few cracks, repainted the gate terribly, but ruined a dining room ceiling when his worker used silicone in a tube instead of the expansion tape, spray ceiling covering, and paint I had purchased saying this silicone was "better". Then they said they would have to paint the whole ceiling and charge extra. They left holes in the walls and did a sloppy paint job in several places. I just paid them to get them out of my home as I felt intimidated as a senior citizen who is handicapped. I will try to have the main guy come back when I let him know what I need redone. Don't know if he will come back without charging me more.
"There's wisdom in a multitude of counsel" {Bible Book of Wisdom/Proverbs} I thank you all I learned so much here not only painting but contracting in general. After all this I realize how blessed my ignorance not taken advantage of by Greater Philadelphia area motivated young skilled pride-in-work honest hardworking + seasoned older employee of Scott Gribling Painting of Lansdale PA. I'm proud I had the idea that Tom Parkinson here taught me the phrase & affirmed paying daily "progress draws" & purchase receipts instead of advance deposit in case something happens to contractor, and as Tom teaches the natural effectiveness of receiving from the day's work :)
I bought this because an excerpt was included at the end of another Orbit book I was reading, and I have to say I feel like I'm reading bad Buffy fanfic. At least two thirds of the characters even share names with Whedon characters, and when I got to the bits about the character called "the Aurelian," I think I actually groaned out loud on the commuter train. Come on, at least name your own characters!
A fellow (actually lives in the same neighborhood) by the name of Wayne Hickey (843-655-0366) painted the ceilings and most of the walls of our house in February 2017. He got paint all over my light fixtures, all over my trim around the doors, and had visible lap marks everywhere on the walls. He came back and rectified some of the problems, but not all, as I have noticed as I have had time to look more carefully at the work he and his assistant did. His assistant had no idea (not a clue) how to roll paint on a wall or ceiling. Some places were not covered. He said he would pull nails for pictures and then re-insert the nails exactly where they were. This he did not do as he promised. He painted over the nails. His assistant had no idea how to use a paint roller. I have painted all my life, and would have done this work myself, but I just had a full knee replacement and the other knee is in bad shape. I just could not do the work. Wayne is a pleasant and congenial individual, but he can not cut in a ceiling or wall to my satisfaction - not even close. He should have a putty knife and wet cloth with him all the time to correct any paint that might get applied where it shouldn't. That is something I always did as a painter. I would not recommend Wayne to paint anybody's home.
Over time, even the best paint job needs a new coat. Old paint peels and fades and those colors that were all the rage ten years ago can start to look a bit dated. With your busy schedule, you've got no time to pick up a paintbrush, and you've just remembered that your in-laws are in town for dinner next week! We hear stories like this all the time, and our reply is always the same: don't panic! Book a painting professional through the Handy platform. Wall painting shouldn't be stressful and when you use the Handy platform, it won't be.
A number of details will affect the cost of painting the exterior of your house, such as its size, accessibility and siding type. In many cases though, preparation often has the biggest impact on the bottom line.Your local exterior painting contractor will take a look at the project to determine how extensive repairs and preparation will be and if special equipment, materials or paints are needed to get the job done right.
Only a dummy gets involved with so-called "contractors." Hire a qualified actual worker yourself. Check out their resume/background, etc. RULE #1..NO ADVANCE DEPOSITS! Pay daily or weekly or upon satisfied completion according your standard, not workers. Contractors are merely employment agents. If that's the way you get work done, then go ahead and waste your money and wind up with the myriad of problems enumerated upon in the news clip above. RULE#2.. NO SMOKERS. They are lighting up on your money. RULE#3: No cell phones while working. Talk on their own time after work
Third: The contractor buys the materials. We get them at a better rate and customers really don't know what they are getting into by being a material racer. Once again, I'm not referring to the guys that paint a bedroom or 2 a week. Tell the homeowner to go grab 50 gallons of paint, $300.00 worth of sundries and related job cost items and I'd be interested to see how it works for them....IT WILL NOT. And if were talking about people getting taken advantage of here, the paint suppliers with no relationship to a homeowner will 100% GOUGE the customer and completely take advantage of them with pricing. Contractors will pay nearly half the price and will still save the customers money marking up paint 10-15%.
I am very satisfied with the job that was done by this company (exterior painting of two-story house). The price was very reasonable. All crew members are very professional, polite, punctual, and always cleaned the place at the end of the day. They did a very thorough preparation before painting and their painting work was exceptional. I am happy to have my house painted by this company. It looks nice, clear, and we have many positive feedback from our neighbors on this work that was done by this company. I highly recommend this company for any painting work.
Do you need to paint your house, but also find yourself thinking of walking out of your office for good and picking up a paint gun instead? Does the thought of simple work with immediate results that you can see everyday sound much better than the frustrating mess of dealing with the people in your "white collar" job? Want to be a craftsman? Well guess what? It's not so simple as you might hope... Great book that will give you insight into the world of painting for a living and the folks who do. The authors website is also full of information on how to do the job right the first time. Much appreciated.
When you choose Five Star Painting residential house painting contractors, you can feel confident that you are hiring the best in the business. Local Five Star painters have been serving clients throughout the United States and Canada since 2004. From taking time to prepare the area to using exactly the right equipment for each job, we make sure the project is done correctly. Our experience shows: We're good at what we do, and our clients are always happy with the work we leave behind!
For the best work, hire a painter who is licensed. And make sure he/she is bonded and insured, with up-to-date, adequate workmen's compensation and liability insurance. There are (at least) two good arguments against hiring unlicensed house painters: 1) even if you sign a contract with them, it may be legally unenforceable, and 2) your homeowner's insurance might not cover against accidents or theft.
When the primer is dry, caulk all small joints (less than ¼-inch-wide) in the siding and trim. Most pros use siliconized acrylics—paint won't stick to straight silicones—but Guertin and O'Neil like the new, more expensive urethane acrylics for their greater flexibility and longevity. O'Neil stresses that it's shortsighted to skimp on caulk. "If the joint fails, you're back to square one." Guertin uses the lifetime rating as his quality guide. "I don't expect 35-year caulk will last 35 years, but it should last longer than a 15-year caulk."
I was a painting contractor for many years and never asked for a deposit upfront. A good contractor should have great credit with his suppliers and an even better contract if the deal should go south before the job is done. Get to know your customer and explain how each paint covers so they understand fully before you have to apply 3 or 4 coats. If you didn't bid your job right and the client has already signed the contract then that is on you not the client. Yes I haven had to eat the difference but the client was happy and a return customer for years so I made up for it.
The color scheme that is chosen for the home creates the initial impression that an individual has of the premises as a whole. Whether complimentary or unflattering colors are selected, the house will gain an identity of its own when the paint is applied. There are many times that a homeowner misses opportunities to accentuate positive attributes that the home has to offer by failing to choose the best exterior paint colors.


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Infantry football Olimpija and Rudar in the 25th round of the First League, Telekom Slovenije separated by a 3: 3 (2: 0). The game's hero is Ljubljančan, but Velenje's Milan Tučić teams put all three goals for the chips.
Because they played against the worst of the competition and had their second best attack, Ljubljana residents were promised three points against Rudar, who would have particular contact with the main Maribor. But, this time the guests took all the problems of Olympic defense to one side, and this kept useful opportunities for the competitors. Thus, the winners of Robert Pevnik can be delighted that the third game at the same time is unconscious, but at the same time, as the difference with Maribor has been raised to 10 points again.
Olimpija has quickly taken over. Now in the sixth minute Stefan Savić left from the front left of the door, where Rok Kidrič was faster than the Matej Radan and got 1: 0. Dha Kidric, this was the seventh goal for the season, and for Savic, a fifth was given.
The Velenje players could equally equal after 13 minutes, but Vitalij Maksimenko pointed up the wrong side of the goal. This would probably be a good opportunity for … Dominik Radić but he didn't get any chance for scoring, and Nejc Vidmar scored him.
Six minutes later, the most difficult punishment was also available at home. Savić ran into the penalty area, with the foot edge of the football already put back over Radan (and also at the door), and then the players struck football, and the referee showed the ball. Bojan Mertik on a white spot. Rok Kronaveter took the opportunity to goals 2: 0 and 11 the season.
Knapi even had hit Ljubljana defense in the first half of an hour, but usually they were inappropriate, with four times quicker. After 34 minutes, Milan Tučić replaced Radića, which gave the lead a good 34 minutes into the game. Ten minutes later she refused to give secret protection because she gave Robert Pušaver a great deal of time and a one-to-one game with Vidmar, which was won by the second.
Knapi was lively half-second, and in 49 minutes the gap was reduced. After a free kick from the left and Aljaz Krefla's step into the penalty area, Tučić 2: 1 from the vote "Kungfu". However, guests took out more after a visit and gave instructions about 3: 1 at the minute. Kidrič reached his eighth season when he pushed the ball from being near the net after burning Savic and the hand of Klemna Bolha.
After the visit, the remainder were given protection to the homeowner, who was released immediately by the elected MS Sulejmanović. Tučić later struck in the 69th minute when it was forgotten and the member went through Radić's day. Olimpija's punishment Velingi sent again, 78 minutes in the game with around 15 meters, sent the ball to the right hand for a 3: 3 top and his ninth goal in the season. Eventually, there was one more chance at the Velenjci, with the reactions of David Hrubik to Vidmar.
Olimpija will be performing at Murska Sobota on Thursday Thursday in Thursday 26th, and Rudar will host Celje on the previous day.
Olimpija – Rudar 3: 3 (2: 0)
Ljubljana – Stads ŠRC Stožice. Chief judge: Bojan Mertik (Odranci).
Gamekeepers: t 1: 0 Kidrič (6), 2: 0 Kronaveter (19, punishment), 2: 1 Tučić (49), 3: 1 Kidrič (67), 3: 2 Tučić (69), 3: 3 Tučić (78).
Olimpija: Vidmar, Maksimenko (from 72. Mujčić), Bagnack, Jurčević, Boakye (from 84. Kregar), Brkić, Tomić, Kronaveter (56. Andrejašič), Suljić, Savić, Kidrić.
Rudar: Radan, Krefl, Bolha, Tomašević, Pušaver, Ćosić, Črnčič (from 71. Pišek), Trifković (from 89. Hrubik), Tučić, Radić (from 76. Kobiljar), Škoflek.
Yellow cards: Bagnack, Suljić; Ćosić, Radan, Tučić, Trifković.
Red cards: – t


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Qaseem, A., Snow, V., Denberg, T. D., Casey, D. E., Forciea, M. A., Owens, D. K., & Shekelle, P. (2009). Hormonal testing and pharmacologic treatment of erectile dysfunction: A clinical practice guideline from the American College of Physicians. Annals of internal medicine, 151(9), 639-649. Retrieved from http://annals.org/aim/article/745155/hormonal-testing-pharmacologic-treatment-erectile-dysfunction-clinical-practice-guideline-from
As blood flows into the penis, the corpora cavernosa swell, and this swelling compresses the veins (blood vessels that drain the blood out of the penis) against the tunica albuginea. Compression of the veins prevents blood from leaving the penis. This creates a hard erection. When the amount of cGMP decreases by the action of a chemical called phosphodiesterase type 5 (PDE5), the muscles in the penis tighten, and the blood flow into the penis decreases. With less blood coming into the penis, the veins are not compressed, allowing blood to drain out of the penis, and the erection goes down.
The information provided does not constitute a diagnosis of your condition. You should consult a medical practitioner or other appropriate health care professional for a physical exmanication, diagnosis and formal advice. Health24 and the expert accept no responsibility or liability for any damage or personal harm you may suffer resulting from making use of this content.
In their extensive review, Bassil and coworkers summarise the benefits and risks, with benefits such as improvement of sexual function, bone density, muscle strength, cognition and overall improvement in quality of life. Among the risks that have been suggested include erythrocytosis, liver toxicity, worsening of sleep apnoea and cardiac function, possibly increasing symptoms of benign prostatic hyperplasia (BPH). They also note that although a possibility of stimulation of prostate cancer has been hypothesised, no scientific or clinical evidence exists to this possible risk.38
The somatosensory pathways for erections originate in the penile skin, glans and urethra. Glans afferent sensory free nerve endings are 10-fold more than their corpuscular receptors, and are derived from Aδ and unmyelinated C fibers. The nerve endings coalesce to form the dorsal penile nerve along with other sensory nerve fibers. Through the pudendal nerve they enter the S2-4 nerve roots to terminate on spinal neurons and interneurons. The dorsal nerve is not purely somatic, however. Nerve bundles within the dorsal nerve contain nitric oxide (NO) synthase, found typically in autonomic nerves, and stimulation of the sympathetic chain can leak to evoked potentials from the dorsal nerve and vice versa (10-12).
Oral therapies via the PDE5i sildenafil, vardenafil, and tadalafil have been proven to be generally safe and effective in select NED populations. The majority of the treatment effectiveness data has been generated in the SCI population. Data regarding the use of PDE5i outside of the SCI population is lacking (58). Furthermore, the ED that exists in the population with neurologic disorders is often multifactorial and may be caused by psychogenic, psychosocial, hormonal, medication-related and disability-related factors. A careful evaluation of each patient must be performed to isolate these factors prior to initiating vasoactive therapy.
Neurogenic erectile dysfunction (NED) is a traditional classification of erectile dysfunction (ED) encompassing disorders impairing erections via neurologic compromise or dysfunction. The disorders compromising erections may act centrally, peripherally or both. The prevalence of neurogenic ED has been suspected to be between 10% and 19% of all causes of ED (1,2). However, several classically defined neurogenic processes may affect several components of the normal pathway to achieve erection e.g., multiple sclerosis (MS), diabetes mellitus, iatrogenic surgical and spinal cord injury. Each disease state has its own unique characteristics that require acknowledgement to fully understand their effect on ED.
Uses and risks of viagra Viagra treats erectile dysfunction and pulmonary arterial hypertension. For sexual purposes, it helps someone with erectile dysfunction achieve and maintain an erection. However, Viagra can have unpleasant side effects, and an overdose can be serious. We cover everything you need to know about Viagra in this article. Read now
Alprostadil is an FDA-approved erectile dysfunction drug that can be injected directly into the penis to trigger an automatic erection. "Penile injection is the most effective type of ED treatment for men who can't take oral treatment," says Nelson Bennett, MD, a urologist at the Lahey Clinic in Burlington, Mass. In fact, it has an 85 percent success rate. Possible side effects include a burning sensation and priapism, an erection that lasts more than four hours and requires medical treatment.
Trauma to the pelvic blood vessels or nerves can also lead result in ED. Bicycle riding for long periods has been implicated as an etiologic factor; direct compression of the perineum by the bicycle seat may cause vascular and nerve injury. [37] On the other hand, bicycling for less than 3 hours per week may be somewhat protective against ED. [37] Some of the newer bicycle seats have been designed to diminish pressure on the perineum. [37, 38]
Physicians make a diagnosis of erectile dysfunction in men who complain of troubles having a hard enough erection or a hard erection that does not last long enough. It is important as you talk with your doctor that you be candid in terms of when your troubles started, how bothersome your erectile dysfunction is, how severe it is, and discuss all your medical conditions along with all prescribed and nonprescribed medications that you are taking. Your doctor will ask several questions to determine if your symptoms are suggestive of erectile dysfunction and to assess its severity and possible causes. Your doctor will try to get information to answer the following questions:
When other treatments haven't helped, a penile implant may be the right solution. A penile implant is a medical device that is surgically placed into a penis to mimic the look and performance of a natural erection9. Implants are custom-fitted to your anatomy. Sensitivity and the ability to ejaculate aren't typically affected either, so you'll be able to have an orgasm normally (unless you have a medical condition that prevents this)7.
In some cases, nocturnal penile tumescence testing is performed to find out whether the man has erections while asleep. Healthy men usually have about four or five erections throughout the night. The man applies a device to the penis called a Rigiscan before going to bed at night, and the device can determine whether he has had erections. (If a man is able to have normal erections at night, this suggests a psychological cause for his impotence.)
ICI Alprostadil may be used as a mixture with two other drugs to treat ED. This combination therapy called "bimix or trimix" is stronger than alprostadil alone and has become standard treatment for ED. Only the Alprostadil ingredient is FDA approved for ED. The amount of each drug used can be changed based on the severity of your ED, by an experienced health professional. You will be trained by your health professional on how to inject, how much to inject and how to safely raise the drug's dosage if necessary.


text:
Psalm 85:8-10
Contemporary English Version
Psalm 85:8-10
Contemporary English Version
8 I will listen to you, Lord God,
because you promise peace
to those
who are faithful
and no longer foolish.
9 You are ready to rescue
everyone who worships you,
so that you will live with us
in all of your glory.
Read full chapter
10 Love and loyalty
10 Love and loyalty
will come together;
goodness and peace
will unite.
Contemporary English Version (CEV)
Copyright © 1995 by American Bible Society
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text:
You need to get one that is listed in the servcie manual I posted above with the HP part number on it. Does anyone own a GLVS? But I bought the laptop anyway and I really like it. The laptop displays no video and the hard drive makes a repetitive clicking noise. I ended up
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Large and spacious... »
Charming stone village... »
£84,408 1 bathroom.
Holiday Cottage with... »
£99,000 3 bedrooms. 2 bathrooms.
Dramatic Price... »
Results 1 - 10 of 139
3 bedrooms and 2 bathrooms.
Delightful 3 bed/2 bath village house with large double garage and electric gates in a quiet lane on the edge of a well-known village with every...
Ref: 260578
9 bedrooms and 4 bathrooms.
Beautiful views across its own land for this lovely 6 bedroom farmhouse with over 4.5 hectares of land, a separate 3 bedroom gite and outbuildings,...
Ref: 262474
Fabulous, detached 3 bedroom, 2 bathroom, recently constructed bungalow on the edge of a small village and a short drive from the sought after town...
Ref: 255203
6 bedrooms and 3 bathrooms.
Magnificent 6 bed manor house, built originally around 1850, with its own gite, in almost 20 acres of beautiful countryside, yet within easy reach...
Ref: 230706
5 bedrooms and 2 bathrooms.
Beautiful nineteenth century demeure in country location, close to a small village with local shops, set in parkland gardens with mature trees and...
Ref: 253883
4 bedrooms and 2 bathrooms.
With its elevated position and views over the vines and surrounding countryside, this attractive property is in very good condition throughout. The...
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8 bedrooms and 3 bathrooms.
Beautifully renovated 8 bed country farmhouse with fabulous pool, set on the edge of a village in almost three acres of glorious mature gardens,...
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6 bedrooms and 2 bathrooms.
Situated in the heart of this delighful Charantais town, surrounded by shops, bars and restaurants, this deceptively spacious town house boasts 6...
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10 bedrooms and 3 bathrooms.
An amazing opportunity to purchase a delightful 4 bed stone property in a sought after village location and with the benefit of 2 self contained 3...
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8 bedrooms and 2 bathrooms.
Lovely, quiet environment with no nearby neighbours for this quality renovation of two Charentaise houses. The first house offers a large living...
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Baignes Ste Radegonde is located in Charente in the Poitou Charentes region of France. The closest airport to Baignes Ste Radegonde is Angouleme Airport (52 km) also nearby are Bordeaux Airport (72 km), Bergerac Airport (85 km), or La Rochelle Airport (115 km).
Around Baignes Ste Radegonde attractions such as as Les Antilles de Jonzac (17 km), Courvoisier Cognac museum in Jarnac (33 km), Rémy Martin Cognac tour, Cognac (33 km), or River Beach Resort at Aubeterre-sur-Dronne (34 km) may appeal. See our local area information above for more information and recommendations on places to stay nearby or you can jump straight to places to stay in Baignes Ste Radegonde or take a look at property in Baignes Ste Radegonde.
I you are looking for ideas other than Baignes Ste Radegonde we have a great selection of places to stay in France and also property for sale in France if you require it. Alternatively you might consider Luxury Holidays In France and Cheap Holidays to Cornwall? Try France Instead... or cottages to rent in france.
For more information on Charente in our guide to Charente or for the area as a whole we also have a comprehensive guide to Poitou Charentes, both of these resources will provide you with a valuable overview of the places you are looking at.
If you have or are planning to visit Baignes Ste Radegonde leave a tip using the link above, we would love to hear from you and other users will appreciate your knowledge.
Some of the common queries we have received from other visitors related to visiting Baignes Ste Radegonde in France include cottage south west france, cottages south west france, cottages in south west france.
South West France
Poitou Charentes
Baignes Ste Radegonde (Charente)


text:
A blueprint for high-volume, high-quality lung cancer screening that is detecting cancer earlier—and helping to save lives
Roughly one in 20 women of childbearing age suffer from major depression, according to a study in the journal Obstetrics & Gynecology, and the Stanford researchers who conducted the study say women in that age group need to be better screened and treated for the condition.
"Given that 54% of women with depression before pregnancy have depression during pregnancy, and that 50% of U.S. pregnancies are unplanned, better diagnosis and treatment of nonpregnant women with depression may reduce the burden of perinatal mental illness," wrote lead author Nan Guo and her colleagues.
Researchers looked at 3,705 nonpregnant women of childbearing age from 2007 to 2014 using data from the National Health and Nutrition Examination Survey. Many women in the age group were not taking antidepressants.
The antidepressants most commonly used by women with major depression were selective serotonin reuptake inhibitors (21.3%), phenylpiperazines (8.4%), and serotonin–norepinephrine reuptake inhibitors (7.2%), the study states.
Researchers were unable to estimate how women recently diagnosed with depression responded to treatment. Also, antidepressants can be used for conditions other than depression, such as insomnia and urinary incontinence.
Women without private health insurance had a 2.5-fold increased risk of major depression. Researchers stated that prior research indicates that patients with mental health problems are more likely to be uninsured and that their "data showed a similar trend, but these associations were not statistically significant."
A blueprint for high-volume, high-quality lung cancer screening that is detecting cancer earlier—and helping to save lives
ZULRESSO™ (brexanolone) injection CIV
Multiple Sclerosis: New Perspectives on the Patient Journey–2019 Update
Summary of an Actuarial Analysis and Report