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Tony Bernhard first encountered the dharma in 1965 and became one of Spirit Rock's first community dharma leaders in 1999. He currently sits on the board of the Sati Center, trains inmates and staff at Folsom Prison in mindfulness and dharma, leads sitting groups in Davis, and regularly teaches in a handful of venues in and around Sacramento and the Bay Area. He primarily focuses his practice on study of the dharma teachings in the earliest texts.
A section from ___, which is some of the oldest text. In fact, I'm going to ___ a portion of that called the ___, which is considered by some scholars to be the oldest layers of the ___. It's referred to specifically on other ___ in the set of scriptures. I'm a particular fan of it, but it's a small book and people won't use it like it's a small book. It's 45 dollars. Tom ___ has translated it. You can find its translation on the web and access to Insight that is available for free.
But I particularly like, because it includes some texts that are incredibly intimate portraits of the Buddha, or snapshots of the Buddha and his thinking. This is the Buddha speaking. This is from a time. These texts are from the time before there was a saga. The very early in his teachings, before there were monks following him around.
This is just look at how people quarrel and fight. Let me tell you know the kind of dismay and terror that I have felt. Seeing people struggling like fish—riding in shallow water with enmity against one another. I became afraid. At one time, I wanted to find some place where I could take shelter, but I never saw any such place. There's nothing in this world that is solid at base and not a part of it that's changeless.
I'd seen them all trapped in mutual conflict. That is why I felt so repelled. But then, I noticed something very deep in their hearts. It was, I could just make it out a barb. It's a barb that's makes its victims run over the place. But once it's been pulled out, all that running is finished, and so is the exhaustion that comes from it.
That barb. That's interesting. It's a barb in the heart. It's not a barb in the mind. So, we're talking last week about ___. And I think, in some way, this is what he's pointing at. It's these built in compulsions. The ongoing need to have our experience pleasant and to continue on more and more. And he's focusing on the tenancy of these barb and these tenancy to quarrel and fight for producing our quarrels and conflicts and violence. It's not the only ground for violence. People fight over food, and resources. Our people fight over views or for ideas. And the Buddha is pretty clear that fighting over views is not what it's about. This is—the Buddha says, "Monks, I do not dispute with the world. Rather, the world disputes with me. A proponent of the Dharma does not dispute with anyone in the world."
You got any disputes?
(speaker and audience laughs)
You know, what is he talking about? You know, that's just something the Buddha and his, you know, I've seen ___. Often, you can see the heavens. Maybe, but down here.
So, another place in the cannon is his cousin ___, who is not a fan. The Buddha came from sort of a dysfunctional family. His cousin tried to kill him. And by pushing a boulder on him and I gathered it left a ___ of stone in his foot. And it was very painful. But ___ was also a cousin and he was not a fan, and there's a story in the ___, the ___, ___ comes across the Buddha, sitting out there in the forest and the jungle and he sort of got this ___. What does this holy man teach? And the Buddha says, "Friend, I assert and proclaim a teaching in such a way that one does not quarrel with anyone in the world, but its Gods, its ___ and ___. In this generation, with ___, its princess and its people, in such a way that perception is no more ___ who abides the ___ from ___ pleasures." It doesn't dispute with anyone in the world.
How do you do that? Is that the path we're on? Or that's just somebody else's path and we're just going to sit and meditate? This is—and then, of course, we open our eyes. Ajchan, ___, some of you may know who shows up here. Sometimes in the summer time, he says he has a woman in his monastery in Thailand who is particularly deaf at the ___'s attainment. And so, absorption. Because the problem is that when she opens her eyes, she's cranky. It's more pleasant with the eyes closed. This is the Buddha, says, "A monk who's mind has liberated sides with none and disputes with none," he employs to speech, he currently used in the world without clinging, without adhering to what he's clinging to it. This is not just one little passage. He is pretty clear. So if the Buddhist here were was looking here for some guidance, and the trick is to figure out what he is talking about. Clinging to views, you know, results in quarrels. Those who've embraced the certain theory and argue over it maintaining that alone the truth, you may talk with such people. But here, there is no opponent to battle with you. The trick of course is to figure out, how do you do that?
What does it mean to cling to a view when you believe a particular idea? A view in this context really means an idea, an understanding, a story, a narrative, it's the map that we use to locate ourselves in the life in our world. And I'm thinking that, you know, this clinging, the depending on it happens, because it provides some security, some stability. If we didn't have our understandings of what's going on, we ___ stability and security even though the world is not offering it, so we sort of make it up, and then we hold on tight.
You know, we don't want… without views, our experience would be uncertain. What's, you know… without our ideas about what's outside this room, it will be so like, it will be a beetle juice.
If you liked this recording and would like to make a direct financial contribution to this teacher, please contact them here: [email protected]
Material on this site is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
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In this study, change detection of stone quarries were determined and evaluated in the northern part of Istanbul by usingLandsat TM and SPOT 5 satellite images and geographic information system. The area of quarries in 1987 and 2001were calculated and the size and direction of expansion was determined by performing Geographic Information Systems(GIS) overlay analysis. Potential quarry areas obtained from Landsat TM images were verified using both highresolution SPOT 5 image and ground truth data. Finally, thematic maps of these areas are created by using appropriatevisualization techniques and the study results are presented on these maps.
After 1950s, in Turkey, especially in Istanbul, there is a rapid expansion in economic growth, cities and urban areas thatresulted in complex problems with rapid urban and industrial development. Between the year of 1975 and 2000, thepopulation of Istanbul has increased from 3 904 588 to 10 018 735 with an annual increase rate of 6,2 %. EspeciallyIstanbul Asian side has started to be occupied by legal and illegal residential and industrial development in that era.This unavoidable overpopulation has resulted significant destruction on agricultural lands and forests in both side ofIstanbul. On the other hand, surface mining activities have destroyed natural areas such as forest and green areas in theBlack Sea coastal part of Istanbul. Study region was selected as an important example in order to present land cover anduse changes based on mining activities and impacts of this change on environment.
Determination of the mining activities impacts on environment is a major issue in sustainable development andresources management. The conflict between mining activities and environmental protection has intensified over recentyears, emphasizing the need for improved information on the dynamics of impacts at regional and local scales(Latifovica et al., 2004). Surface mining activities range from large open-cast coal and base metal mines, to muchsmaller aggregate (rock, gravel and sand), industrial minerals (potash, clay) and building materials (granite, stone andmarble) quarries. Mapping mining activities and evaluating associated environmental concerns are difficult problemsbecause of the extensive area affected and the large size of individual mines. Monitoring and controlling these changeshave been more difficult because of the expense and time in producing reliable and up-to-date mapping. Besides, asuccessful monitoring approach for evaluating surface mining processes and their dynamics at a regional scale requiresobservations with frequent temporal coverage over a long period of time to differentiate natural changes from thoseassociated with human activities. In order to meet such challenges, urban planners and decision makers need to haveaccurate and up-to-date information. Since the 1970s analog aerial photographs have been used for mapping spatialchanges in mined areas (Anderson, 1977). Today, satellite remote sensing can provide this information moreeffectively.
Satellite remote sensing, in conjunction with geographic information systems, has been widely applied and recognizedas a powerful and an effective tool in detecting land use and land cover change (Harris and Ventura, 1995; Weng, 2001;kaya et al, 1998). Integration of these technologies have often been used by decision makers as informative and visualanalytical tools in order to monitor and determine the surface mining activities and their impacts on the environment ina quick and cost efficient way. On the other hand, visualization of the processed remotely sensed data by using effectivetools and techniques provides significant benefits for the users from different environmental sciences. Thus,cartography takes vital role in this process for obtaining effective visual outputs. In this concept, well designed maps areused as the best communication tools while sharing the information with the users. A number of published papers(Schmidt and Glaesser, 1998; Prakash and Gupta, 1998; Wright and Stow, 1999) suggest usefulness of such techniques
XXII International Cartographic Conference (ICC2005) A Coruña, Spain, 11-16 July 2005 Hosted by: The International Cartographic Association (ICA-ACI)ISBN: 0-958-46093-0 Produced by Global Congresosfor detecting contamination, determining success in reclaiming open cast mined areas and for providing other relevantspatial data for assessing mining impact on the environment.
This study is conducted an assessment on land cover change of the northern part of Istanbul by means of multitemporalsatellite images with the aim of identifying changes due to surface mining activities and its impacts on environment.Used method depends on comparative analysis of independently-classified two Landsat TM images in GISenvironment.
1987 and 2001 dated Landsat TM images and 2002 dated SPOT 5 image were used to determine the extension anddirection of quarries and land cover/use changes in the concerned area. Landsat TM and SPOT 5 images have 30 m and5 m spatial resolution, respectively. Satellite sensor images including the study are shown in Figure 1.
Ground photographs were taken and field survey was performed in the study region in order to provide ground truthdata for further analyses. Moreover, aerial photographs and topographic maps were used in rectification andclassification process.
In this study, the northern part of Istanbul, which has faced with expansion of stone quarries, a kind of surface miningactivity was selected as study area. The region represented in Figure 2 is located between Black Sea and northwest ofIstanbul and comprises approximately 8323.65 ha area. This area has changed considerably in a twenty years periodbecause it includes potential sites for mining activities.
Rectification, classification, GIS integration and presentation were applied to dataset in order to perform aim of thestudy in an accurate way. Moreover, all processes in the methodology were supported by ground truth data andtopographic maps. Methodology applied in the study is mentioned in the following parts.
In the rectification process, the mathematical relationship between the addresses of pixels in an image and thecorresponding coordinates of those points on the ground is established using geometric model (Richards and Jia, 1999).Coordinates of Ground Control Points (GCPs) were obtained from topographic maps and first order polynomialequations were used as geometric model. Root Mean Square Errors (RMSE) of rectifications were 0.52 and 0.51 for1987 and 2001 Landsat TM images, respectively. RMSE of SPOT 5 image rectification was 2.22 pixels. After therectification, all images were cut in a common boundary including the border of study site.
The purpose of digital land cover classification is to link the spectral characteristics of the image to a meaningfulinformation class value, which can be displayed as a map so that resource managers or scientists can evaluate thelandscape in an accurate and cost effective manner (Weber and Dunno 2001). ISODATA (Iterative Self OrganizingData Analysis Technique) unsupervised classification technique was applied to classify the remotely sensed images.
The number of clusters was chosen as 50 for both of the images, the convergence threshold was set as 0.98 and thenumber of iteration was 20. Four land cover types for study region were evaluated and used in this study. These arewater, forest, stone quarry and others (urban or built-up land, barren land etc.). Figure 3 shows the statistical results ofclassified images in 1987 and 2001.
GIS can be defined as an organized collection of computer, hardware, software, geographic data and personnel toefficiently capture, store, update, manipulate, analyze, and display all forms of geographically referenced information(Clarke, 2002). Geographic Information Systems provides not only a medium for combining spatial data but it is also apowerful technology for the quantitative analysis of land use changes and map updating (Treitz et.al., 1992). Itscapabilities on manipulation and analysis of spatial information make GIS an indispensable vector based solution forassessing environmental problems. On the other hand, presentation tools, which are used for communication of theinformation obtained as a result of the analysis in GIS, add another dimension to this technology for being so popular.
In this study, GIS is used for analyzing and visualizing the classification results obtained by remote sensing technology.Classification results of the remotely sensed images dated 1987 and 2001 in vector format were imported to the GIS into two different layers including land cover classes -water, forest, stone quarry and others- as the sub layers (see Figure4). Overlay analyze was executed on these layers for detecting the changes of the quarry areas. Visualization of theanalyze results was considered as another important issue in this study. Thematic maps emphasizing the changes in thequarry areas and showing the direction of the extension of the mining activities were designed to better understand theresults of study.
a b N
Water Stone Quarry Forest Other New Quarry Areas
This paper indicates that how remote sensing and GIS techniques are integrated in order to establish land cover changesin the northern part of Istanbul between the year of 1987 and 2001. As it is seen in Figure 3, there have beenconsiderable land cover changes in the study region during the 14 years period as a result of surface mining activities. Itwas found that the area of stone quarries was 393,39 ha in the year of 1987, this value has notably increased to 1080,45ha in the year of 2001. The area of forest decreased to 6478,38 ha from 7161,03 ha in 14 years period. This means thatthe forest area was decreased about % 8 between the year of 1987 and 2001. However, the area of others was 761,67 hain the year of 1987, this value decreased 749,61 ha in the year of 2001. On the other hand, in the field surveys it is seenthat the change in the water area is derived from the mining activities as a result of the large mining holes filled bywater. These significant results show that the study area has not affected by the urbanization yet and the most of theforests in the study area destroyed as a result of the mining activities. The statistical results of classification obtained byusing RS technology verified visually in GIS environment (see Figure 4). Thematic maps designed for visualizing theresults of the overlay analysis show that mining activities have increased for 14 years in the study area. While theamount of the water bodies has been increasing in expansive stone quarries, forests were cut up drastically. Besides as itis seen in Figure 5 mining activities have expanded 687,06 ha through southern part of the study area.
Within the framework of this study, for the detection of possible land cover change in the concerned region usingLandsat TM data was realized. The digital image classification conducted with GIS has proved its ability to obtaincomprehensive information on the direction, magnitude, and location of land cover changes as a result of miningactivities. Results of the study show that mining activities have significant effects on the environment. Especially inTurkey these effects have not seriously taken in to consider. Although mining activities should be organized by terms ofsustainable development, mining activities have been executed illegally. In this concept, the distribution and expansionof these activities should be monitored, their environmental damages should be determined; mitigation studies againstthese damages should be performed, and regular inspections should be executed to keep these activities under control.Modern technologies should be used to obtain more effective results from these studies. Although monitoring thechanges in large areas by using conventional method is very difficult, remote sensing is the most convenient techniqueto collect a large amount of data for this kind of areas. With the ability of satellite data, it is possible to detect andanalyze the magnitude and spatial changes of natural environment which is significant for resource managers.Additionally, GIS technique is used to summarize changes in the spatial distribution of land cover classes by overlayingmap of different dates and analyze their spatial coincidence for helping in decision making process in order to projectfuture land development.
Anderson, A.T., 1977. Landsat imagery for surface mining inventory. Photogrammetric Engineering and RemoteSensing., 8, 1027–1036.
Clarke, K.C., 2002. Getting Started With GIS, Prentice Hall, USA.
Harris P. M. and Ventura S. J. (1995). The integration of geographic data with remotely sensed imagery to improveclassification in an urban area. Photogrammetric Engineering and Remote Sensing., 61, 993-998.
Kaya, S., Musaoglu, N., Ormeci, C., and Muftuoglu, O. 1998. Forest Damage Assesment by using Remote SensingData.ISPRS Commision IV Symposium on GIS- Between Vision and applications, Vol.32/4, 284-1987.
Latifovica, R., Fytasb, K., Chenc, J., and Paraszczakb, J. 2005. Assessing land cover change resulting from largesurface mining development. International Journal of Applied Earth Observation and Geoinformation.7, 1, 29-48.
Prakash, A., and Gupta, R.P., 1998. Land-use mapping and change detection in a coal mining area—a case study in theJharia coalfield, India. International Journal of Remote Sensing. 19, 3, 391–410.
Richards, J. A., Jia, X., 1999, Remote Sensing Digital Image Analysis, 3rd edn (New York: Springer).Schmidt, H., and Glaesser, C., 1998. Multitemporal analysis of satellite data their use in the monitoring of theenvironmental impact of open cast mining areas in Eastern Germany. International Journal of Remote Sensing. 19, 12,2245–2260.
Treitz P. M. and Hobbs N. T. (1992). Forecasting rural land use change: a comparision of regression and spatialtransition-based models. Geographical and Environmental Modelling., 2, 65-82.
Weber and Dunno, 2001, Riparian vegetation mapping and image processing techniques, Hopi Indian Reservation,Photogrammetric Engineering and Remote Sensing, Arizona, pp. 179 – 186.
Weng Q. (2001). A remote sensing – GIS evaluation of urban expansion and its impact on surface temperature in theZhujiang Delta, southern China. International Journal of Urban and Regional Studies., 22, 425-442.
Wright, P., Stow, R., 1999. Detecting mining subsidence from space. International Journal of Remote Sensing. 20, 6,1183–1188.
Ahmet Ozgur Dogru was born in 1979 in Aydın-Turkey. He attended to the Istanbul Technical University (ITU)Geodesy and Photogrammetry Engineering in 1997. He has started Geomatic Engineering Over Graduate Program inITU Institute of Science and Technology in the year of 2002. He started to work in Istanbul Technical University,Cartography Division (Department of Geodesy and Photogrammetry Engineering) as a research assistant in the sameyear. After he had finished over graduate program he started his PhD in the same university. He is still working onnavigation systems in terms of the map design for navigation purposes. Moreover he is working on GIS.

subset: commoncrawl


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PublixDirect, the online grocery shopping subsidiary of Lakeland-based Publix Super Markets Inc., will start deliveries Oct. 8 to customers living or working in one of 13 ZIP codes in northwest Broward and south Palm Beach counties.
During the week of Sept. 24, PublixDirect tested its system by opening it to a small number of customers in those same areas. E-mails about the test program were sent to customers who had signed up at the PublixDirect.com site to request more information.
Tom O'Connor, president of PublixDirect, said he was "pleasantly surprised" at the response, but wouldn't give exact numbers for the trial run.
"We had just enough to tweak and tune and test the system," he said, indicating that one night the warehouse shipped out 38 orders on four routes.
In the next three weeks, PublixDirect hopes to double its delivery area, mostly east and south of the current area in Broward County, reaching an additional 28 ZIP codes by year's end.
The online shopping site won't be open to its entire service area, which encompasses a 25-mile radius of its Pompano Beach distribution center, or a total of approximately 84 ZIP codes, until spring, 2002.
"We want to roll it out in phases, hiring and training new people as we need them," he said. PublixDirect currently employs 76 in its warehouse and 50 in its Alpharetta, Ga., headquarters.
The parent company has budgeted $51 million to fund the subsidiary's first year of operation, but O'Connor would not say when the online grocery is expected to be profitable.
In its 140,000 square-foot Pompano warehouse, employees called "shoppers" work with a small computer strapped to one wrist and a scanner wrapped around one finger.
They follow directions from the wrist computer screen and pick groceries off the shelves in areas set aside for dry goods, perishables and frozen foods.
"We can take ice cream out of our minus-18 degree freezer room and put it into the freezer on the truck and deliver it rock hard," said Bill Berry, director of fulfillment operations.
Employees scan the products as they put them into bags set into bar-code labeled bins, color-coded for each category.
The filled bins are then put on a conveyer belt, which scans them and directs them to the right bay for the delivery truck designated for that neighborhood.
The warehouse has its own meat cutting area and bakery, and will slice some fresh deli products. The online service will offer a total of about 12,500 items, compared to 40,000 in a typical Publix store.
Christine Winter can be reached at firstname.lastname@example.com or 954-356-4664.


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OIST team proposes a novel ocean-current turbine design.
Fossil fuels propelled the Industrial Revolution and subsequent technological advances. However, our future cannot be based on them, if only because they are a finite resource; and we are very close to exhausting them.
Solar and wind power is often seen as the main locomotive of the energy revolution. However, it is becoming increasingly clear that solar panels and wind turbines alone cannot provide all the energy we need, especially considering that energy consumption around the world is steadily growing. Due to day-night cycles and seasonal weather patterns, solar and wind power is inherently intermittent. Moreover, utility-scale power farms will require vast tracts of land.
Ocean currents are another source of power, comparable to fossil fuels in terms of consistency and reliability, and at the same time, clean and renewable.
In the journal, Renewable Energy, the Quantum Wave Microscopy Unit at Okinawa Institute of Science and Technology Graduate University (OIST) proposed a design for a submerged marine turbine to harness the energy of the Kuroshio Current, flowing along the Japanese coast. This design is especially suitable for regions regularly devastated by storms and typhoons, such as Japan, Taiwan, and the Philippines. The turbine operates in the middle layer of the current, 100 m below the surface, where the waters flow calmly and steadily, even during strong storms.
"Our design is simple, reliable, and power-efficient", says Dr Katsutoshi Shirasawa, a staff scientist in the Quantum Wave Microscopy Unit. The turbine comprises a float, a counterweight, a nacelle to house electricity-generating components, and three blades. Minimising the number of components is essential for easy maintenance, low cost, and a low failure rate.
The OIST design is a hybrid of a kite and a wind turbine: an ocean-current turbine is anchored to seabed with a line and floats in the current while water rotates its three blades. Ocean currents are rather slow, averaging 1-1.5 m/s. However, water is over 800 times as dense as air, and even a slow current contains energy comparable to a strong wind. Additionally, currents do not stop or change direction.
The OIST team, led by Prof. Tsumoru Shintake, head of the Quantum Wave Microscopy Unit, built a prototype turbine and conducted various experiments to test its design and configuration. Results confirmed the robustness and stability of the turbine construction. The achieved efficiency is comparable to that of commercial wind turbines.
The design can easily be scaled up or down, depending on local conditions and needs. Dr. Shirasawa and his colleagues aspire to build an energy farm featuring 300 turbines 80 m in diameter. The expected output is about 1 GW — the equivalent of one nuclear reactor, capable of powering over 400,000 homes. This project will be an important step toward development of green energy.
Learn more: Taming Oceans for 24/7 Power
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- Marine Power Market Report Analysis and Market Insights for Highly Profitable Investment Decision: Industry Outlook by 2024on November 29, 2019 at 3:33 am
The waves and tides are used to produce electricity by the stored heat of the surface water. This tidal energy, wave energy, ocean current energy, etc have the huge capability of priding the ...
- Analyzing Lake Worth Beach's travel budget: Was $39,000 well spent?on October 22, 2019 at 3:15 pm
They attended the U.S. Conference of mayors where Mayor Pam Triolo accepted an award for the city's proposed Ocean Current Energy project and attended an additional energy conference. Four months ...
- Modec unveils Skwid hybrid turbine concepton September 11, 2019 at 5:00 pm
Japanese marine contractor Modec has unveiled a hybrid offshore energy concept that marries a three-bladed vertical axis wind turbine (VAWT) with a Savonius ocean-current turbine. Japanese marine ...
- Ocean Current Energy Electric Generator Market Size, Status and Growth Opportunities by 2019 to 2025on August 8, 2019 at 1:12 am
Aug 08, 2019 (HTF Market Intelligence via COMTEX) -- HTF MI Analyst have added a new research study on Title Global Ocean Current Energy Electric Generator Market Insights, Forecast to 2025 with ...
- Saudi entrepreneur eyes world's largest ocean energy projecton May 29, 2019 at 3:28 am
OceanBased Perpetual Energy, led by Saudi entrepreneur Nasser MN Alshemaimry, inks deal to assist in developing the world's largest commercial ocean current energy project OceanBased Perpetual Energy, ...
- Minesto Takes Steps Towards World's First Ocean Current Electricity Generationon January 16, 2018 at 11:09 pm
Swedish marine energy developer Minesto intensifies activities in Taiwan to establish the company's unique Deep Green technology in the Asian market. Local staff have been recruited to a newly ...
- Japanese Professor Builds Wave Energy "Flowers"on October 2, 2017 at 5:01 pm
Firstly, Shintake aims to harness energy from the Kuroshio ocean current that flows from the eastern coast of Taiwan and around the southern parts of Japan. This "Sea Horse" project uses submerged ...
- Submerged Turbines Could Replace 10 Nuclear Reactors In Japanon October 2, 2017 at 8:00 am
Professor Shintake and the Quantum Wave Microscopy Unit at OIST began by starting a project titled "Sea Horse," aiming to harness energy from the Kuroshio ocean current that flows from the eastern ...
- Scientists develop turbine that can harness electricity from ocean currents - Reporton September 27, 2017 at 12:09 am
Researchers from the Okinawa Institute of Science and Technology Graduate University in Japan began a project titled "Sea Horse," which aims to harness energy from the Kuroshio ocean current that ...
- New Turbine Design Converts Ocean Waves into Clean Energyon September 22, 2017 at 6:52 am
That year, Professor Shintake and the Quantum Wave Microscopy Unit at OIST began a project titled "Sea Horse," aiming to harness energy from the Kuroshio ocean current that flows from the eastern ...
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Find Top-Rated Greenville Carpet Installers
There are 5 top-rated carpet installers in your area.
Rileys LLC (Empire Today Sales Rep).
Business Description: BUSINESS IS PERMANENTLY CLOSED Thank you
Color Your Carpet
Business Description: Our unique "Carpet Color Care" services are providing residential and commercial property owners with a cost-effective alternative to costly and usually unnecessary carpet replacement. Savings of 50% to 85% compared to carpet replacements costs. Faded, stained, wrong color, outdated color, wrong color or just plain ugly carpet- we are the original and only complete on-site carpet dyeing and color restoration service company in the USA. Certified Carpet Dyemasters and Colorists perform our services in more than 200 locations worldwide. Color restoration of Oriental rugs and all fine rugs are our specialty, Design dyeing services offered on wall-to-wall or area rugs. No obligation inspections and proposal performed by appointment. Dyes are safe, MSDS on hand, flawless safety record for 25+ years. Educational and informative information about anything and everything concerning all aspects of carpet and rugs are provided on Color Your Carpet websites.
A&E Remodeling
Business Description: **Call us today for a FREE ESTIMATE!** With over 10 years of experience, A&E Remodeling will beat any competitors' quote, and your satisfaction is guaranteed. Call us today and see why our clients refer us to everyone!
Marett Carpet One Floor & Home
Business Description: Marett Carpet One is family run and operated since it first opened in 1949, by Tom Marett. Today, his son Craig Marett is proud to carry on his legacy of providing great service and great flooring. Marett Carpet joined Carpet One in 1988, which has made us part of the largest buying group in the country. This upper hand helps us provide customers with various and unique options to suit their flooring, cabinet and counter top needs. We are a co-op, and therefore we represent the best of both worlds. By shopping with Marett Carpet One, customers are supporting their local business, but still have access to products they may find at a big box store. Additionally, all of our sales team and installation crews are trained professionals with years of experience. We even have an interior designer on staff! Our installation crews are in-house employees, and most have been with Marett Carpet One for decades.
The Don Booth Co
Business Description: Founded in 1954, The Don Booth Company has a rich history and a proud family heritage. We are a complete floor covering center in North Jackson, Ohio featuring a wide selection of area rugs, carpets, vinyls, vinyl tiles, hardwoods & laminates, ceramics, porcelains, and more. Rest assured that you will find a brand and style that meets your taste, standards, and budget. We have and offer everything you need in flooring. Uses subs for installation. Cost is determined by the job. Additional address - PO Box 367, North Jackson OH 44451. Additional contact name - Chuck Booth. Additional DBA - Booth Co, Don Booth Co.
M E S Home Improvement
Business Description: Interior remodeling specialist. Specializing in kitchens and bathrooms. Also whole house renovation projects. We have many resources to provide you with all the pieces needed to complete your project, We pride on quality not quantity. This company is built for remodeling and service. We pay attention to the details. NOW INSTALLING DOG SHOWERS ! 🐶
Empire Today®
Business Description: Empire Today®, Makes Beautiful New Floors Easy. Call 877-799-9131 for Carpet, Laminate, Hardwood, Vinyl, or Tile flooring. Empire is the easiest way to get the best value and a professional experience. Call 877-799-9131 to Schedule a FREE In-Home Estimate and samples will be brought right to your home. Get professional room measurements and an all-inclusive price estimate. We offer professional installation when you want it around your schedule. Empire's convenient shop-at-home service and professional installation let you skip the hassles of home improvement store shopping. We carry quality name brand floors from industry leading brands. Because of our national footprint and manufacturer relationships, Empires great prices include your floor, installation, materials, and more. Empire Today is dedicated to customer satisfaction and has been a leading provider of installed home improvements and home furnishings for over 55 years. Call 877-799-9131 NOW to schedule your FREE In-Home Estimate. For more information, visit EmpireToday.com.
Business Description: we have finance options available,we do sub - contracting.We also give up to $100.00 for referals.
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Biviano Carpet One
Business Description: We are a locally owned family business since 1947. In 1996 we joined Carpet One the largest supplier of flooring in the U.S. We provide flooring for residential remodeling, main street commercial, commercial and insurance restoration customers. We offer free in-home measures and free estimates for jobs involving installation by our professional crews. 12 months zero interest financing available. Alternate Phone Number: 330-306-9706
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Business Description: YOUR ART & DECOR is a website that offers 1, 2, 3, 4, & 5 piece wall art that always arrives framed. All orders have free global shipping with no minimum purchase required. We offer, hand paintings, ethic art, modern art, kids art, and many other types of framed wall art. Our window treatments come in complete sets. Our valance sets include complete valance, customization, tiebacks, wall hooks, 2 black out curtains and 2 sheer curtains all included in as little as 140 per meters. All costs are included in one flat rate. We also offer modern & shag rugs. All purchases are covered by our money back guarantee.
Explore Our Solution Center for Helpful Carpet Installer Articles
Carpet Installation reviews in Greenville
ATONDO CARPETS INCI would highly recommend Tondo Carpet.
I initally had a different company install my carpet. They used 12 foot carpet, leaving seams running down the middle of 3 of my bedrooms (it also took 2 men 4 days to complete the job!).
When I went to the Tondo showroom and gave them my room sizes the sales representatives immediately mentioned that I had to have 15 foot carpet to avoid seams. With that first statement from the sales rep. I was impressed, because they knew off the bat the correct size carpet I needed.
Tondo had the carpet available at thier warehouse in five days, we scheduled an installation date, and it took them one day to install it. They arrived at 8:30 A.M. and were done by 5:00 P.M.
While here their men took the time to explain, every step of the way, what they were doing and why. They worked quickly and efficently and were respectful to myself and my belongings.
The carpet edging around the walls is well tucked in without any loose fibers, a noticible difference from the other companys installation.
The whole experiece compared to my first carpet installation was like night and day.
I would highly recommend Tondo carpet, and would have them work in my home again in a heart beat.
Very professional from the sales reps. to the installers. A+++++
- Lydia C.
BMarett Carpet One Floor & HomeAlthough we didn't finish with them - they gave us very professional service and in a timely manner. They should be recommended in the future to anyone wanting flooring installed. The only reason we didn't finish with them is that we went through an acquaintance and saved some money. They beat other estimates hands down.
- Randy W.


text: Join March Movement. Change the World. Social media: great for staying connected, also great for enabling trolls. Let's face it – sometimes Facebook, Twitter and Instagram… by Nicola Dowse access_time3 years ago Social media is changing the ways celebrities communicate Social media has revitalised the way that everyone communicates, so it should come as no surprise that it has changed… by Courtney Allan access_time3 years ago Mark Hamill Dubs Trump's Tweets As The Joker It's something we never knew we wanted, yet desperately needed. Mark Hamill reading president-elect Donald Trump's tweets as the Joker… by Nizza Munoz access_time3 years ago See No Evil: How social media hinders physical activism "By giving people the power to share, we're making the world more transparent." – Mark Zuckerberg. When yet another rocket that… by Lachlan Maddock access_time3 years ago Facebook Cracks Down on Fake News Facebook is introducing new tools in an effort to put an end to the sharing of fake news on its platform.… by Tracy Bustamante access_time3 years ago Instagram isn't sending notifications for all screenshots Instagram has been trying very VERY hard to be like Snapchat. By trying to be like one of its competitors,… by Courtney Allan access_time3 years ago "Facebook Famous as F#@k" Justin Ryan and Gem Gem I'm sure most people on Facebook have either seen or have been tagged in the videos of Justin Ryan (he… by Jayden McComiskie access_time3 years ago Facebook Advertising Tools Spark Racial Profiling Fears Imagine if a newspaper offered advertisers the option of only placing certain ads in copies that went to white readers.… by Frankie Johns access_time3 years ago Woolies Finally Teaches Us How To Make Steamed Hams After receiving hundreds of inquiries on how to cook a steamed ham – a reference to a classic Simpsons episode… by Tracy Bustamante access_time3 years ago Sorry Guys – Standing Rock Check-Ins Probs Not Helping You've undoubtedly seen one recently. Maybe you've even done it yourself. Since Monday 31 October, Facebook has been awash with… by Nicola Dowse access_time3 years ago Posts navigation navigate_beforePrev 1 … 8 9 10 Nextnavigate_next


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Betsy & Adam Plus Size Sequined Lace Sheath Dress
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The #mombod movement is going viral and its a beautiful thing. Women across the country are embracing their bodies through social media networks such as Instagram. Mom's of all shapes and sizes are making headway as they post no filter pictures of their post-baby bodies filled with stretch marks, lumps, bumps and all its glory.
"I think it's great that #dadbod is becoming socially acceptable but now it's time to make #mombod socially acceptable and embraced by all!" wrote one Instagram user.
Many say its great to be supportive of women who are working hard to get fit after having kids. The emphasis shouldn't be on weight loss, rather embracing your new and improved body.
@candykjo adds: "It is an incredible honour to have a mom bod :) Two years and 8 months after giving birth to twins. This is my mom bod."
The #mombod movement is a replicable of the #dadbod movement and is rejuvenating the way women feel about their bodies. Instagram is becoming a major hit. Women are exploiting their bodies in a natural, beautiful way.
"So everyone's been doing the #dadbod thing," wrote @tiffohm1130831. "Then I heard that #mombod is now a thing too. Well, here's #mombod.... This body carried and birthed 2 children. It's not society's perfect bod but it's mine and it is pretty amazing what this "bod" has done. Embrace the #mombod all my beautiful mom's out there."
How does the #mombod movement make you feel?
We ship within Canada and the United States via FedEx with expedited 2-Day shipping.
For locations outside of the US and Canada, we ship using FedEx International, which is usually in transit for 5-7 business days, depending on location.
We ship all of our physical products with FedEx, from our warehouse location in Kingston, Ontario, Canada. Signatures are required on all orders.
BodyRock Equipment
We offer a 30-day return policy, as long as: it is not more than 30 days past the date of delivery; and your item is in its original condition and packaging with the original order number. Refunds will be issued when the equipment is received back to the BodyRock warehouse, minus the original cost of shipping, and the customer is responsible for the costs of return shipping. To request a refund on physical product purchases, please contact us.
Digital Products
We cannot issue refunds on digital goods such as e-books or videos, as these are non-tangible goods that are irrevocable once the order is placed.
All of the BodyRock clothing is made to order and so is final sale. If you have any questions about sizing prior to placing your order, please contact us.


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OBJECTIVE: Mounting evidence suggests that higher optimism is associated with reduced risk of age-related morbidities and premature mortality. Yet, possible biological mechanisms underlying these associations remain understudied. One hypothesized mechanism is a slower rate of cellular aging, which in turn delays age-related declines in health. METHODS: We used data from two large cohort studies to test the hypothesis that higher optimism is associated with longer leukocyte telomere length. Using cross-sectional data from the Health and Retirement Study (HRS; N=6,417; mean age=70 years) and the Women's Health Initiative (WHI; N=3,582; mean age=63 years), we used linear regression models to examine the association of optimism with relative telomere length (assessed in leukocytes from saliva [HRS] or plasma [WHI]). Models adjusted for sociodemographics, depression, health status, and health behaviors. RESULTS: Considering both optimism and telomere length as continuous variables, we found consistently null associations in both cohorts, regardless of which covariates were included in the models. In models adjusting for demographics, depression, co-morbidities, and health behaviors, optimism was not associated with mean relative telomere length (HRS: ß=-0.002; 95% CI:-0.014, 0.011; WHI: ß=-0.004; 95% CI:-0.017, 0.009). CONCLUSIONS: Findings do not support mean telomere length as a mechanism that explains observed relations of optimism with reduced risk of chronic disease in older adults. Future research is needed to evaluate other potential biological markers and pathways.
RATIONALE: Shorter leukocyte telomere length (LTL) is associated with reduced health-related quality of life and increased risk for acute exacerbations (AEs) and mortality in chronic obstructive pulmonary disease (COPD). Increased physical activity and exercise capacity are associated with reduced risk for AEs and death. However, the relationships between LTL and physical activity, exercise capacity, and AEs in COPD are unknown. METHODS: Data from 3 COPD cohorts were examined: Cohort 1 (n = 112, physical activity intervention trial), Cohorts 2 and 3 (n = 182 and 294, respectively, separate observational studies). Subjects completed a 6-minute walk test (6MWT) and provided blood for LTL assessment using real-time PCR. Physical activity was measured as average daily step count using an accelerometer or pedometer. Number of self-reported AEs was available for 1) the year prior to enrollment (Cohorts 1 and 3) and 2) prospectively after enrollment (all cohorts). Multivariate models examined associations between LTL and average daily step count, 6MWT distance, and AEs. RESULTS: A significant association between longer LTL and increased 6MWT distance was observed in the three combined cohorts (ß = 3x10-5, p = 0.045). No association between LTL and average daily step count was observed. Shorter LTL was associated with an increased number of AEs in the year prior to enrollment (Cohorts 1 and 3 combined, ß = -1.93, p = 0.04) and with prospective AEs (Cohort 3, ß = -1.3388, p = 0.0003). CONCLUSIONS: Among COPD patients, increased LTL is associated with higher exercise capacity, but not physical activity. Shorter LTL was associated with AEs in a subgroup of cohorts.
Mitochondrial DNA (mtDNA) is susceptible to oxidative stress and mutation. Few epidemiological studies have assessed the relationship between mtDNA copy number (mtDNAcn) and risk of colorectal cancer (CRC), with inconsistent findings. In this study, we examined the association between pre-diagnostic leukocyte mtDNAcn and CRC risk in a case-control study of 324 female cases and 658 matched controls nested within the Nurses' Health Study (NHS). Relative mtDNAcn in peripheral blood leukocytes was measured by quantitative PCR-based assay. Conditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association of interest. Results showed lower log-mtDNAcn was significantly associated with increased risk of CRC, in a dose-dependent relationship (P for trend < 0.0001). Compared to the 4th quartile, multivariable-adjusted OR (95% CI) was 1.10 (0.69, 1.76) for the 3rd quartile, 1.40 (0.89, 2.19) for the 2nd quartile, and 2.19 (1.43, 3.35) for the 1st quartile. In analysis by anatomic subsite of CRC, we found a significant inverse association for proximal colon cancer [lowest vs. highest quartile, multivariable-adjusted OR (95% CI) = 3.31 (1.70, 6.45), P for trend = 0.0003]. Additionally, stratified analysis according to the follow-up time since blood collection showed that the inverse association between mtDNAcn and CRC remained significant among individuals with ≥ 5 years' follow-up, and marginally significant among those with ≥ 10 years' follow-up since mtDNAcn testing, suggesting that mtDNAcn may serve as a long-term predictor for risk of CRC. In conclusion, pre-diagnostic leukocyte mtDNAcn was inversely associated with CRC risk. Further basic experimental studies are needed to explore the underlying biological mechanisms linking mtDNAcn to CRC carcinogenesis.
STUDY DESIGN: Cross-sectional study OBJECTIVES: To determine clinical factors associated with telomere length in persons with chronic spinal cord injury (SCI). SETTING: Veterans Affairs Medical Center, Boston, MA. METHODS: Two hundred seventy-eight participants with chronic SCI provided blood samples for measurement of C-reactive protein (CRP), interleukin-6 (IL-6), and telomere length, completed respiratory health questionnaires, underwent dual X-ray absorptiometry (DXA) to assess body fat, and completed spirometry. High-throughput real-time PCR assays were used to assess telomere length in leukocyte genomic DNA. Linear regression models were used to assess cross-sectional associations with telomere length. RESULTS: Telomere length was inversely related to age (p < 0.0001). In age-adjusted models, gender, race, injury duration, %-total and %-trunk fat, body mass index (BMI), %-predicted forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1), chronic cough or phlegm, CRP, IL-6, wheeze, smoking, diabetes, heart disease, chronic obstructive pulmonary disease (COPD), skin ulcer, urinary tract infection (UTI), or chest illness history were not significantly associated with telomere length. There was a suggestive age-adjusted association between persons with the most severe SCI (cervical motor complete and AIS C) and shorter telomere length (p = 0.055), an effect equivalent to ~8.4 years of premature aging. There were similar age-adjusted associations with telomere length between persons using a wheelchair (p = 0.059) and persons with chronic urinary catheter use (p = 0.082) compared to persons without these characteristics. CONCLUSIONS: Our results suggest that clinical characteristics such as decreased mobility and bladder dysfunction that are common in individuals with more severe SCI are associated with shorter telomere length.
BACKGROUND: Leukocyte telomere length has been associated with risk of subsequent pancreatic cancer. Few prospective studies have evaluated the association of prediagnostic leukocyte telomere length with pancreatic cancer survival. METHODS: We prospectively examined the association of prediagnostic leukocyte telomere length with overall survival (OS) time among 423 participants diagnosed with pancreatic adenocarcinoma between 1984 and 2008 within the Health Professionals Follow-up Study, Nurses' Health Study, Physicians' Health Study, and Women's Health Initiative. We measured prediagnostic leukocyte telomere length in banked blood samples using quantitative PCR. Cox proportional hazards models were used to estimate HRs for OS with adjustment for potential confounders. We also evaluated 10 SNPs at the telomerase reverse transcriptase locus. RESULTS: Shorter prediagnostic leukocyte telomere length was associated with reduced OS among patients with pancreatic cancer (P trend = 0.04). The multivariable-adjusted HR for OS comparing the lowest with highest quintiles of leukocyte telomere length was 1.39 (95% confidence interval, 1.01-1.93), corresponding to a 3-month difference in median OS time. In an analysis excluding cases with blood collected within 2 years of cancer diagnosis, the association was moderately stronger (HR, 1.55; 95% confidence interval, 1.09-2.21; comparing the lowest with highest quintiles; P trend = 0.01). No prognostic association or effect modification for the prognostic association of prediagnostic leukocyte telomere length was noted in relation to the studied SNPs. CONCLUSIONS: Prediagnostic leukocyte telomere length was associated with pancreatic cancer survival. IMPACT: Prediagnostic leukocyte telomere length can be a prognostic biomarker in pancreatic cancer.
PURPOSE: Telomere length is considered a biomarker of human aging and premature morbidity and mortality which has been associated with chronic stress. METHODS: We assessed the relation between perceived racism and telomere length in the Black Women's Health Study, a follow-up study of U.S. black women begun in 1995. Participants were asked about frequency of "everyday racism" (e.g., "people act as if they think you are not intelligent") and "institutional racism" (e.g., "ever treated unfairly due to race by police"). Using quantitative real-time polymerase chain reaction assay, relative telomere lengths (RTL) were measured as the copy number ratio of telomere repeat to a single control gene in 997 participants. Associations of racism variables with log-RTL were estimated by multivariable linear regression, with adjustment for age at blood draw and potential confounders. RESULTS: Participants were aged 40-70 years (mean = 55.6 years), and mean telomere length was 0.77 (range 0.21-1.38). In stratified analyses, there was an inverse association between everyday racism and log-RTL among women who did not discuss their experiences of racism with others (ß = -0.1104; 95% CI = -0.2140 to -0.0067; P = .045). CONCLUSIONS: Everyday racism was associated with shorter telomere length among women who reported not discussing those experiences with others.
Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.
AssuntosDoenças Autoimunes/genética , Predisposição Genética para Doença , Linfoma não Hodgkin/genética , Alelos , Feminino , Antígenos HLA/genética , Humanos , Masculino , Pessoa de Meia-Idade , Herança Multifatorial/genética , Polimorfismo de Nucleotídeo Único/genética , Fatores de Risco
OBJECTIVES: Several single-nucleotide polymorphisms (SNPs) have been associated with Barrett's esophagus (BE) risk. In addition, environmental factors including smoking, alcohol consumption, and heartburn increase BE risk. However, data on potential interactions between these genetic and environmental factors on BE risk are scant. Understanding how genes and environmental risk factors interact may provide key insight into the pathophysiology of BE, and potentially identify opportunities for targeted prevention and treatment. The objectives of this study were to examine the main effects and the potential effect modification between known genetic loci (SNPs) and established environmental risk factors for BE. METHODS: We performed a nested case-control study using data on 401 incident BE cases and 436 age-matched controls from the Nurses' Health Study, Nurses' Health Study II, and Health Professionals Follow-up Study cohorts, who gave blood and completed biennial questionnaires. Overall, we genotyped 46 SNPs identified in previous BE genome-wide association studies as well as SNPs in candidate genes related to BE susceptibility (i.e., related to excess body fat, fat distribution, factors associated with insulin resistance, and inflammatory mediators). A genetic risk score (GRS) was constructed to evaluate the combined effect of the selected SNPs on BE risk. Interactions between SNPs and BE risk factors were also assessed. RESULTS: We observed a suggestive, but not statistically significant, association between our GRS and BE risk: a one-allele increase in the unweighted GRS increased the risk of BE by a factor of 1.20 (95% confidence interval = 1.00-1.44; P = 0.057). We did not observe any meaningful multiplicative interactions between smoking, alcohol consumption, or heartburn duration and BE genotypes. When we assessed the joint effect of weighted GRS and BE risk factors, we did not observe any significant interaction with alcohol and heartburn duration, whereas smoking showed a significant multiplicative interaction (P = 0.016). CONCLUSIONS: Our results suggest that SNPs associated with BE at genome-wide significant levels can be combined into a GRS with a potential positive association with BE risk.
To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.
AssuntosAdaptação Fisiológica , Astronautas , Voo Espacial , Imunidade Adaptativa , Peso Corporal , Artérias Carótidas/diagnóstico por imagem , Espessura Intima-Media Carotídea , Dano ao DNA , Metilação de DNA , Microbioma Gastrointestinal , Instabilidade Genômica , Humanos , Masculino , Homeostase do Telômero , Fatores de Tempo , Estados Unidos , United States National Aeronautics and Space Administration
BACKGROUND: Telomeres cap and protect DNA but shorten with each somatic cell division. Aging and environmental and lifestyle factors contribute to the speed of telomere attrition. Current evidence suggests a link between relative telomere length (RTL) and depression but the directionality of the relationship remains unclear. We prospectively examined associations between RTL and subsequent depressive symptom trajectories. METHODS: Among 8,801 women of the Nurses' Health Study, depressive symptoms were measured every 4 years from 1992 to 2012; group-based trajectories of symptoms were identified using latent class growth-curve analysis. Multinomial logistic models were used to relate midlife RTLs to the probabilities of assignment to subsequent depressive symptom trajectory groups. RESULTS: We identified four depressive symptom trajectory groups: minimal depressive symptoms (62%), worsening depressive symptoms (14%), improving depressive symptoms (19%), and persistent-severe depressive symptoms (5%). Longer midlife RTLs were related to significantly lower odds of being in the worsening symptoms trajectory versus minimal trajectory but not to other trajectories. In comparison with being in the minimal symptoms group, the multivariable-adjusted odds ratio of being in the worsening depressive symptoms group was 0.78 (95% confidence interval, 0.62-0.97; p = 0.02), for every standard deviation increase in baseline RTL. CONCLUSIONS: In this large prospective study of generally healthy women, longer telomeres at midlife were associated with significantly lower risk of a subsequent trajectory of worsening mood symptoms over 20 years. The results raise the possibility of telomere shortening as a novel contributing factor to late-life depression.
AssuntosEnvelhecimento/genética , Envelhecimento/psicologia , Depressão/diagnóstico , Depressão/genética , Encurtamento do Telômero/fisiologia , Telômero/metabolismo , Adulto , Transtorno Depressivo/diagnóstico , Transtorno Depressivo/genética , Feminino , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores de Risco , Telômero/genética , Encurtamento do Telômero/genética
Relations of DNA methylation markers to other biological aging markers and to psychosocial, behavioral, and health measures remain unclear. The sample included 23 participants (n = 11 cases with psychiatric diagnoses and n = 12 controls without current or lifetime psychiatric disorder), balanced by age and sex. Genomic DNA was extracted from blood samples; the following were performed: genome-wide DNA methylation assay using Illumina 850k methylationEPIC; PCR assays for relative telomere length (RTL) and mitochondrial DNA copy number (mtCN). Exposures were: case status; depression and anxiety symptoms; psychosocial support; subjective and objective cognition. Outcomes were: DNA methylation age (DNAm age); RTL; mtCN; extrinsic and intrinsic epigenetic age acceleration (EEAA and IEAA). Stronger correlation with chronological age was observed for DNAm age (ρ = 0.86; p < 0.0001) compared to RTL (ρ = -0.53; p < 0.01); mtCN was not correlated with age. DNAm age was more strongly correlated with behavioral and health variables than RTL or mtCN; e.g., correlations with DNAm age: body mass index (ρ = 0.36; p = 0.10); smoking pack-years (ρ = 0.37; p = 0.08); physical activity (ρ = -0.56; p = 0.01); alcohol intake (ρ = 0.56; p = 0.01). DNAm age was inversely correlated with psychosocial support (ρ = -0.42; p = 0.048) and Modified Mini-Mental State score (ρ = -0.44; p = 0.01). Anxiety, psychosocial support, and objective cognition were significantly related to accelerated aging; depression and subjective cognition were not. In conclusion, DNAm age correlated more strongly with chronological age and key psychosocial, behavioral, and health variables than RTL or mtCN. Signals for associations with epigenetic aging were observed for psychosocial and neurobehavioral variables.
Background: Mitochondrial dysfunction is an important component of the aging process and has been implicated in the development of many human diseases. Mitochondrial DNA copy number (mtDNAcn), an indirect biomarker of mitochondrial function, is sensitive to oxidative damage. Few population-based studies have investigated the impact of fruit and vegetable consumption and cigarette smoke (2 major sources of exogenous antioxidants and oxidants) on leukocyte mtDNAcn. Objectives: We investigated the association between fruit and vegetable consumption, cigarette smoke, and leukocyte mtDNAcn based on data from the Nurses' Health Study (NHS). Methods: Data from 2769 disease-free women in the NHS were used to examine the cross-sectional associations between dietary sources of antioxidants, cigarette smoke, and leukocyte mtDNAcn. In vitro cell-based experiments were conducted to support the findings from the population-based study. Results: In the multivariable-adjusted model, both whole-fruit consumption and intake of flavanones (a group of antioxidants abundant in fruit) were positively associated with leukocyte mtDNAcn (P-trend = 0.005 and 0.02, respectively), whereas pack-years of smoking and smoking duration were inversely associated with leukocyte mtDNAcn (P-trend = 0.01 and 0.007, respectively). These findings are supported by in vitro cell-based experiments showing that the administration of naringin, a major flavanone in fruit, led to a substantial increase in mtDNAcn in human leukocytes, whereas exposure to nicotine-derived nitrosamine ketone, a key carcinogenic ingredient of cigarette smoke, resulted in a significant decrease in mtDNAcn of cells (all P < 0.05). Further in vitro studies showed that alterations in leukocyte mtDNAcn were functionally linked to the modulation of mitochondrial biogenesis and function. Conclusions: Fruit consumption and intake of dietary flavanones were associated with increased leukocyte mtDNAcn, whereas cigarette smoking was associated with decreased leukocyte mtDNAcn, which is a promising biomarker for oxidative stress-related health outcomes.
AssuntosFumar Cigarros/efeitos adversos , Variações do Número de Cópias de DNA , DNA Mitocondrial , Dieta , Leucócitos , Mitocôndrias/fisiologia , Fumaça/efeitos adversos , Envelhecimento , Antioxidantes/farmacologia , Biomarcadores/metabolismo , Estudos Transversais , Comportamento Alimentar , Feminino , Flavanonas/farmacologia , Frutas/química , Humanos , Cetonas/efeitos adversos , Pessoa de Meia-Idade , Mitocôndrias/genética , Nicotina/efeitos adversos , Nitrosaminas/efeitos adversos , Oxidantes/efeitos adversos , Estresse Oxidativo/efeitos dos fármacos , Fumaça/análise , Produtos do Tabaco/efeitos adversos , Verduras/química
INTRODUCTION: Particulate air pollution is probably causally related to increased risk of cardiovascular disease. Plasma homocysteine is an established cardiovascular disease risk factor. Recent studies show that exposure to particulate air pollution is associated with plasma homocysteine levels in adults but no studies on the association between prenatal air pollution and neonatal homocysteine levels exist. METHODS: In 609 newborns of the ENVIRONAGE (ENVIRonmental influence ON early AGEing) birth cohort, we investigated the association between prenatal particulate matter exposure with a diameter ≤ 2.5⯵m (PM2.5) and cord plasma homocysteine levels, and in a subset (nâ¯=â¯490) we studied the interaction with 11 single nucleotide polymorphism (SNPs) in oxidative stress-related genes (CAT, COMT, GSTP1, SOD2, NQO1 and HFE), through multiple linear regression. PM2.5 levels were obtained using a high resolution spatial temporal interpolation method. Homocysteine levels were measured by the homocysteine enzymatic assay on a Roche/Hitachi cobas c system. SNPs were assessed on the Biotrove OpenArray SNP genotyping platform. RESULTS: In multivariable-adjusted models, cord plasma homocysteine levels were 8.1% higher (95% CI: 1.9 to 14.3%; pâ¯=â¯0.01) for each 5⯵g/m³ increment in average PM2.5 exposure during the entire pregnancy. With regard to pregnancy trimesters, there was only an association in the 2nd trimester: 3.6% (95% CI: 0.9% to 6.4%; pâ¯=â¯0.01). The positive association between PM2.5 in and homocysteine was (borderline) statistically significantly modified by genetic variants in MnSOD (p interactionâ¯=â¯0.02), GSTP1 (p interactionâ¯=â¯0.07) and the sum score of the 3 studied SNPs in the CAT gene (p interaction=0.09), suggesting oxidative stress as an underlying mechanism of action. CONCLUSIONS: Exposure to particulate air pollution in utero is associated with higher cord blood homocysteine levels, possibly through generating oxidative stress. Increased air pollution-induced homocysteine levels in early life might predispose for cardiovascular and other diseases later in life.
AssuntosPoluentes Atmosféricos , Poluição do Ar/estatística & dados numéricos , Homocisteína/sangue , Exposição Materna/estatística & dados numéricos , Adulto , Feminino , Sangue Fetal , Humanos , Recém-Nascido , Material Particulado , Gravidez
The Mediterranean diet (MD) is a gold standard for nutrition and the most evidence-based diet to delay the onset of age-associated pathologies. Telomeres are the heterochromatic repeat regions found at the ends of eukaryotic chromosomes, whose length is considered a reliable hallmark of biological ageing. Telomere shortening is, at least in part, a modifiable factor and there is evidence that adherence to the MD is associated with longer telomeres. Data from several studies indicate an association between "inflammatory/oxidative status" and telomere length (TL). The MD, as a complex exposome with thousands of nutrients and phytochemicals, may positively influence telomere attrition by reducing inflammation and oxidative stress. However, it is unclear whether the protective effects on TL provided by the MD result from its individual constituents or some combination of these. Furthermore, these properties of the MD and its components are not yet fully validated by clinical endpoints in randomized trials or observational studies. Here, we summarize the data from experimental and population-based studies on the effects of the MD on TL maintenance. We will both highlight the possible role of the MD in the prevention of age-associated diseases, and attempt to identify certain aspects of the diet that are particularly important for telomere maintenance.
Traumatic stress is thought to be associated with shortened telomere length (TL) in leukocytes, an age-related marker of increased risk for cellular senescence, although findings thus far have been mixed. We assessed associations between posttraumatic stress disorder (PTSD) symptom severity, temperament, and TL in a sample of 453 White, non-Hispanic, middle-aged, trauma-exposed male and female veterans and civilians. Given that prior research has suggested an association between PTSD and accelerated cellular age, we also examined associations between TL and an index of accelerated cellular age derived from DNA methylation data (DNAm age). Analyses revealed that, controlling for chronological age, PTSD was not directly associated with TL but rather this association was moderated by age, ß = -.14, p = .003, ΔR2 = .02. Specifically, PTSD severity evidenced a stronger negative association with TL among relatively older participants (≥ 55 years of age). In a subset of veterans with data pertaining to temperament (n = 150), positive emotionality, and, specifically, a drive toward achievement, ß = .26, p = .002, ΔR2 = .06, were positively associated with TL. There was no evidence of an association between age-adjusted TL and accelerated DNAm age. Collectively, these results indicate that older adults may be more vulnerable to the negative health effects of PTSD but that traits such as achievement, resilience, and psychological hardiness may be protective. These findings underscore the importance of identifying reliable biomarkers of cellular aging and senescence and of determining the biological mechanisms that contribute to stress-related disease and decline.
Assessing DNA methylation profiles in human blood has become a major focus of epidemiologic inquiry. Understanding variability in CpG-specific DNA methylation over moderate periods of time is a critical first step in identifying CpG sites that are candidates for DNA methylation-based etiologic, diagnostic and prognostic predictors of pathogenesis. Using the Illumina MethylationEPIC [850K] BeadArray, DNA methylation was profiled in paired whole blood samples collected approximately 1 year apart from 35 healthy women enrolled in the Nurses Study II cohort. The median intraclass correlation coefficient (ICC) across all CpG loci was 0.19 [Interquartile Range (IQR) 0.00-0.50]; 74.8% of ICCs were in the low range (0-0.5), 16.9% in the mid-range of ICCs (0.5-0.8), and 8.3% in the high-range of ICCs (0.8-1). ICCs were similar for CpG probes on the 450K Illumina array (median 0.17) and the new probes added to the 850K array (median 0.21). ICCs for CpG loci on the sex chromosomes and known metastable epialleles were high (median 0.71, 0.97, respectively), and ICCs among methylation quantitative trait loci (mQTL) CpGs were significantly higher as compared to non-mQTL CpGs (median 0.73, 0.16, respectively, P < 2 × 10-16). We observed wide variation in DNA methylation stability over a 1-year period. Probes considered non-stable, due to substantial variation over a moderate period of time and with minimal variability across individuals could be removed in large epidemiological studies. Moreover, adjusting for technical variation that arises from using high-dimensional arrays is critical.
We evaluated the short-term effects of a flavanol-rich cocoa (FRC) on lipid profile and selected oxidative stress biomarkers such as oxidized low-density lipoprotein (oxLDL), glutathione (GSH), and F2-isoprostane. We also assessed whether FRC modulates plasma levels of polyunsaturated fatty acids (PUFA) in healthy individuals. The subjects (n=48) were randomly assigned to a low-cocoa group (1 g/d; ~55 mg flavanols) (n=16), middle-cocoa group (2 g/d; ~110 mg flavanols) (n=16), or a high-cocoa group (4 g/d; ~220 mg flavanols) (n=16). The samples were collected at baseline, at 1, 2, and 4 h post initial consumption of FRC, and after 4 weeks of FRC supplementation. The peak plasma concentration of (-)-epicatechin metabolites reached a maximum level (578±61 nM; P<.05) at 2 h after ingestion of FRC. After 4 weeks, total cholesterol (-12.37±6.63; P<.0001), triglycerides (-3.81±2.45; P<.0001), plasma LDL (-14.98±6.77; P<.0001), and oxLDL (-95.61±41.69; P<.0001) decreased in the high-cocoa group, compared with baseline. We also found that plasma high-density lipoprotein (HDL) (+3.37±2.06; P<.0001) concentrations increased significantly in the same group. Total GSH significantly increased in all FRC-treated groups (+209.73±146.8; P<.0001), while urinary F2-isoprostane levels decreased in the middle- (-0.73±0.16; P<.0001) and high-cocoa (-1.62±0.61; P<.0001) groups. At the end of the four-week study, a significant reduction of arachidonic acid (AA)/eicosapentaenoic acid (EPA) ratio was observed in the low-(-2.62±2.93; P=.003), middle- (-5.24±2.75; P<.0001) and high-cocoa (-7.76±4.96; P<.0001) groups, compared with baseline. Despite the small sample size used in this study, these data extend previous clinical and experimental studies, providing new insights into the health benefits of cocoa flavanols.
Prior studies have reported significant cross-sectional associations between depression or anxiety and shorter telomere lengths, but the temporality of associations is uncertain. Little is known regarding whether shorter telomere length is related to increased risk of developing depression or anxiety. In this study, using the genetic tool of polygenic risk score (PRS), we evaluated the association between genetic predisposition to shorter telomere length and the risks of lifetime clinically significant depression (defined by self-reported clinician/physician diagnosis, antidepressant use, and/or presence of severe depressive symptoms) and of clinically meaningful anxiety symptoms among 17,693 female participants of European ancestry. The weighted PRS of telomere lengths (TLs) combined the dosage of nine alleles that were significantly associated with inter-individual variation in TLs in published genome-wide association studies. Higher score of PRS, corresponding to shorter TL in the literature, was significantly associated with shorter relative TLs (pâ¯=â¯0.008). However, higher PRS was not associated with the lifetime risk of either depression or anxiety. Furthermore, higher PRS was not associated with long-term patterns of depressive symptom trajectories or specifically with later-life onset of depression or anxiety. In summary, this study did not observe a significant association between genetic predisposition to shorter telomere length and risk of depression and anxiety in a large sample of mid-life and older white women. However, these genetic variants jointly account for a limited proportion of interpersonal variation in leukocyte telomere length. Future studies will need to incorporate more genetic variants to improve the accuracy of predicted power, as such data become available.
The co-author name Immaculata DeVivo was incorrectly published. The correct name is given below.
Adiposity may cause adverse health outcomes by increasing oxidative stress and systemic inflammation, which can be reflected by altered telomere length (TL) and mitochondrial DNA copy number (mtCN) in peripheral blood leukocytes. However, little is known about the influence of lifetime adiposity on TL and mtCN in later life. This study was performed to investigate the associations of lifetime adiposity with leukocyte TL and mtCN in 9613 participants from the Nurses' Health Study. A group-based trajectory modelling approach was used to create trajectories of body shape from age 5 through 60 years, and a genetic risk score (GRS) was created based on 97 known adiposity susceptibility variants. Associations of body shape trajectories and GRS with dichotomized TL and mtCN were assessed by logistic regression models. After adjustment for lifestyle and dietary factors, compared with the lean-stable group, the lean-marked increase group had higher odds of having below-median TL (OR = 1.18, 95% CI 1.04, 1.35; P = 0.01), and the medium-marked increase group had higher odds of having below-median mtCN (OR = 1.28, 95% CI 1.00, 1.64; P = 0.047). There was a suggestive trend toward lower mtCN across the GRS quartiles (P for trend = 0.07). In conclusion, telomere attrition may be accelerated by marked weight gain in middle life, whereas mtCN is likely to be reduced persistently by adiposity over the life course. The findings indicate the importance of lifetime weight management to preserve functional telomeres and mitochondria.


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88-year-old retired soldier rescues Pitbull's child after attempting to kill with Molly
The young girl was rescued from pit bull who attacked her by an 88-year-old army veteran. Army men protected her from the dog by hitting the dog with a Christmas decoration.
The 88-year-old Leonard Miller served as a combat doctor in Korea. He used a 3 foot plastic nutcracker to control the dog on Sunday afternoon until he left his 10-year-old neighbor in Perry Township, Ohio.
He wanted a baseball bat to save her from the dog when the girl came to his home, but immediately went out with the girl to control the dog. I said.
Then he decided not to disarm to fight the dog. As a result, he was armed with a nutcracker that belonged to the neighborhood's Christmas exhibition, and then entered the house.
He said. He had her arms and beckoned her to shake animals and something. "
He continued, "I hit the dog's head 3-4 times, but it does not break."
Soon after Miller began beating the dog with a decorative piece, the dog finally released the girl's grip, which ran in front of the house with her sister.
Three men, who have already served 36 prisons and have now escaped all murders, locked up their dogs before calling an ambulance from an innocently injured girl.
The girl was hospitalized with a severe injury on her left arm.
Miller said, "The dog was vicious, I do not know what they're trying to do … I could not sleep because of everything that happened yesterday."
Miller also said he was glad he could help the innocent. At that time, what could have happened to the girl.


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See how Ashley's skills helped YWAM Converge on a Google AdWords Set Up project.
John H.
YWAM Converge
YWAM Converge is a network of ministries in YWAM International. The YWAM Converge Network is led by a growing core group of Managing Partners who lead regional and vocational ministry teams focused on one or more spheres of influence, such as the arts, business, education, media, and more.
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What did John need?
We are building our brand as a new internship placement platform for host organizations to create and administer internships and for students to select a specific missions project and get effective online and personal coaching as they prepare to complete a unique final project for the host organization. Ads will help raise our visibility for hosts seeking interns and students seeking internships.
Matched OnNov 27, 2019
Have professionals like Ashley help you on a Google AdWords Set Up projectPost this project
Ashley V.
I'm here to make connections and usher in change. I want to help you expand the reach of your brand through various digital marketing platforms. I do this with a creative background, clear communication, and a smile. Volunteering is a great way to stay informed about the community. I'm eager to ...
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What did Ashley have to offer?
I side with the helpers and philanthropy. Specifically for your project, I like that you are connecting youth with life changing missions. I lived in Latin America for 8 months on an exchange program, and gained so much world knowledge. This experience has had a lasting influence on my path. Let's get those google ads running so we can expand your reach, and help make memories. I have hands-on experience setting up Google Ads for Non-Profits, Analytics tracking, and running PPC Campaigns. I am also well versed in other aspects of digital marketing having attain a diploma in digital marketing. Here are my strong points: -Google Ads, Display Network, Tag, and Analytics -Campaign and Keyword planning -Ad Copywriting -Conversion Tracking


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News | 11 November 2019
The City of Stonnington has long been a passionate supporter of recycling, and this year is no different. During National Recycling Week from 11 to 17 November we have a range of initiatives planned to help our community get their recycling sorted.
Are you a recycling legend?
We challenge you to a quick quiz to test your recycling knowledge. Complete the quiz and go in the draw to win great prizes!
Take the quiz now
Meet a recycling A-lister
Did you know that aluminium is almost endlessly recyclable? And, an aluminium can can be back on the shelf in as little as 60 days from when you tossed it in the recycling bin!
Drop in to our customer service centre at 311 Glenferrie Road to see the two huge aluminium foil orbs and learn tips and tricks for recycling right.
Celebrating our recycled roads
During the week visit streets across Stonnington whose road surfaces are made up of recycled products including plastic bags and toner cartridges.
To make the recycled roads easier to spot, we've added chalk stencils, so take a look before the rains makes them disappear! See if you can see a difference between a traditional road surface and the new recycled surface ... we can't!
Here's where we've put the stencils:
A visit from the giant purple e-waste eater!
During the week Council's giant purple e-waste eater will be visiting three local primary schools for a school community e-waste collection day. For the past few weeks our Environment team have been working with students from Malvern Valley, Armadale and Windsor primary schools to promote the upcoming collection day and teach the school community the importance of recycling e-waste.
Last updated: 12 November 2019
The City of Stonnington acknowledges that we are on the traditional land of the Boonwurrung and Wurundjeri people and offer our respects to the elders past and present. We recognise and respect the cultural heritage of this land.