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It's the end of another busy week for us here at Designer Websites, and it looks like the rest of the tech and marketing world have been up to their eyeballs too! Once again there are a bunch of things on our radar that we'd love to share with you this week; from a double resignation at Google to 2020 website preparations. Intrigued? Just keep reading...
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If you've ventured on social media anytime this week you might have seen images like this popping up all over the place. Well, that's because we've come around to the Spotify wrapped time of year, where listeners get an in-depth overview of their musical habits. That's right, those guilty pleasures and Disney-sing-alongs and Karaoke classics are about to be showcased for all to see! This year, Spotify has made their roundups social media-friendly, much to the disappointment of Apple Music users, who haven't been treated to these luxuries!
It looks like some big changes to the Google management structure are beginning to take shape. Larry Page and Sergey Brin, currently CEO and President of Alphabet, are to step aside leaving Google CEO Sundar Pichai to take the reigns for Alphabet too. They've said they will remain in the company as active shareholders and board members!
The year is coming to a close and we're starting to see reminders that now is a great time for reflecting and adjusting your SEO strategy.
If you've been focusing on building engagement on socials, writing engaging blogs or optimising your site content, it might be time to switch things up a bit! Why not dedicate some time to build some valuable backlinks, or pursue adding eye-catching video content to your site?
Start to plan your business goals for 2020 and consider how you can tweak your current strategy to suit them! Our SEO team always recommend at this time of year is a dose of healthy competitor analysis.
Take a look around competitor sites, find out what they've been doing, who's linking to them and make sure you haven't missed an opportunity to reach new audiences. You might notice your competitors holding festive competitions at this time of year, which is something your audience can really share and engage with!
Here are a few pointers to help you refresh your SEO strategy:
These are just a few ideas to get you started, keep checking back to see our helpful SEO based blogs throughout the year. We'll see you next week for another DW roundup. Have a lovely weekend!
With the calendar now well into December, it's officially acceptable to fill your car with Christmas tunes and crank up the volume to a chassis-shaking, bell-jingling 11+.
To help you get your yuletide off to a flier, we've put together a festive playlist to get you in the Christmas spirit faster than Phil Mitchell at a free bar.
Chosen by the various members of DW team, this varied collection is a mixed bag of Christmas classics, festive favourites and holiday anomalies – and we mean varied…
If variety is the spice of life, consider this playlist to be a melodic lamb madras. Tuck in!
Making its debut in 1994, it's hard to believe that Mariah Carey's Christmas classic is celebrating its 25th anniversary this year – all the more reason to add it your playlist and play it loud and proud!
A festive favourite for many, Miss Carey's anthemic December tune is so popular that it even broke Spotify's global single-day streaming record on Christmas Eve Last year, clocking up almost 11 million streams!
Since its release, the song has been covered by countless artists, including everyone from Arianna Grande and Shania Twain to My Chemical Romance and Bowling for Soup.
An altogether different yet equally awesome addition to the playlist, 1987's "Christmas in Hollis" proved that the festive airwaves are strictly reserved for radio-friendly pop music.
This tinsel-tastic track by New York rappers, Run DMC, originally appeared on a benefit album in aid of the Special Olympics. Solidifying its status as a Christmas classic, "Christmas in Hollis" even makes a memorable appearance in the opening five minutes of Die Hard – which definitely IS a Christmas film!
Despite being directed by an NYU film student, the video for "Christmas in Hollis" went on to win Rolling Stone's 1987 "Best Video of the Year" award, incredibly edging out Michael Jackson's music video for "Bad" directed by Martin Scorsese.
Justin Beiber traded his cap for a Christmas hat back in 2011 with this reggae-inspired holiday tune. By January 1st 2012, the track had reached an impressive 722k downloads, selling more copies in a calendar year than any previous holiday song in digital history.
Included on Beiber's Christmas album, "Under the Mistletoe", the song helped the album shoot straight to #1 on the Billboard 200 in the US. As a result, Beibs became the first artist to record three #1 albums before the age of 18.
Prior to its official release, Beiber debuted the track live in front of over 45k screaming fans Rio de Janeiro's Olympic Stadium on October 6th. Despite the fact it was over two and a half months before Christmas, the crowd lapped it up!
When it comes to warm and fuzzy Christmas songs, it's fair to say that Tenacious D and Sum 41 are two bands that aren't the first that spring to mind. Luckily, this tune from 2001 is neither warm nor fuzzy, instead offering breakneck festive fun in a 3-minute joyride.
Brushing aside the typical paint-by-numbers approach of seasonal song-writing, "Things I Want" is a yule-tirade of demands from Jack Black to St Nick, ranging from a time machine and a robot pelican to Pamela Anderson's speedo top and a statue of Moby.
Jack Black would return for another crack at the Christmas collaboration in 2010, teaming up with comedy actor, Jason Segel, to cover David Bowie and Bing Crosby's "Peace on Earth/Little Drummer Boy" mash-up.
Hitting the airwaves in 1980, "Stop the Cavalry" was never intended to be a Christmas song; however, the line "Wish I was at home for Christmas" led management to change course and take the festive approach.
In hindsight, Jona Lewie will be glad they did. The song has become a yuletide mainstay and, according to Lewie himself, the song's royalties account for 50% of his annual income.
Upon its release, "Stop the Cavalry" reached #3 in the UK Singles Chart. It was kept off the top spot by two reissued John Lennon tracks following his untimely death that same month.
The brainchild of Leigh Francis, "Proper Crimbo" hit the airwaves almost two decades ago in 2003 and, while the cast of characters in the video may show its age, the song itself hasn't lost any of its catchiness.
A true ear-worm in every sense, the song itself reached #4 in the UK Singles Chart back in December '03. While it remained in the charts for nine weeks, it's remained in our hearts ever since!
Leigh Francis would return to the music charts ten years later in 2013, this time behind the legendary tasche of Keith Lemon with the fittingly titled "I Wanna Go On You".
Despite turning 61-years-old this December 1958's "Rockin' Around the Christmas Tree" isn't showing any signs of age and is a firm favourite of many during the festive period.
Incredibly, Brenda Lee recorded the song when she was just 13-years-old. While the song was largely unsuccessful upon its release, it's gone on to snowball into an absolute staple.
The track was also memorably included in 1990s Christmas classic, Home Alone, further cementing its status as a solid-gold Christmas classic.
Famously covered by Kim Wilde and Mel Smith for Comic Relief in 1987, the cover version actually peaked higher than the original, reaching #3 in the UK Singles Chart to the original's #6.
For anyone growing up in the '90s, South Park was a true phenomenon, blending outrageous cartoon antics with expletive-riddled adult comedy in one ridiculous package. This song is no different…
Released in 1997, "Mr Hankey, the Christmas Poo" brings a whole new meaning to the term "yule log". Howdy ho, everybody!
The following year, South Park would have another crack at the music charts with "Chocolate Salty Balls", as sung by Chef (aka Isaac Hayes). Incredibly, Chef's contribution went on to #1 in the UK Singles Chart in December '98.
What wintry playlist would be complete without being graced with the unmistakable opening piano notes of Shane MacGowan's 1987 classic, "Fairytale of New York"?
A true iron-clad staple of the Christmas period, the song has endured year-after-year and has remained timeless since its debut. In fact, following its re-release in 2005, the song has made an appearance in the UK Top 20 every December since!
MacGowan, himself actually born on Christmas Day, apparently wrote the song as part of a bet with Elvis Costello. It's fair to say that MacGowan probably won that bet and has been laughing all the way to the bank every Christmas since!
Rounding out the list in style is 2003's the crotch-hugging, lycra-clad classic from The Darkness. Filled with trademark falsetto singing, outrageous outfits and face-melting guitar solos, it's everything you could want it to be and more.
Channelling the festive tunes of '70s glam-rockers Slade and Wizzard, Justin Hawkins and Co. go all out in their festive foray into snowy song-writing with more cheeky lyrics than your average track from The Cheeky Girls. A true Christmas crowd-pleaser!
Despite being hotly-tipped to be Christmas #1, "Christmas Time" by The Darkness was pipped at the post by a depressing cover of Tears for Fears' "Mad World" by Gary Jules. According to Music Week, they were beaten by just 5k copies.
So, there you have it – 10 festive favourites from the DW team to help you get in the Christmas mood and kickstart your own Christmas playlist. Merry Christmas from everyone here at Designer Websites!
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If you are in charge of a Facebook page, at the helm of an Instagram account or managing a Twitter profile for your business, you are probably already acquainted with the ins and outs of social media.
Likewise, sitting behind the wheel of a company's social media will mean you are also probably well-acquainted with the cocktail of frustrations that come with it, accompanied by a seemingly endless "happy hour" of headaches.
From fluctuating engagement figures and inexplicable unfollows to negative comments and spam, the various vexations of social media management can be a common complaint for anyone looking to bolster their brand's social standing.
In order to help lighten the load and improve your social standing, picking your spots is a key factor. Read on, as we explore the best time to post on social media to ensure your posts and pages gain traction and don't fall behind.
Social media can be a harsh mistress that's also high maintenance. Constantly changing and ever-evolving, the online realm of digital networking can be a tough beast to tame.
However, with that being said, there are certain behaviours and user patterns that have helped identify the best times to post on social media (at least in theory).
To help you get a handle on your social media struggles, here are a few tips on when to post to get the highest engagement and garner the most eyeballs.
If you're posting on social media for business purposes, it's logical to engage with your following when most people are going to be available to see your posts and interact with them.
Naturally, posting at 03:00 a.m. will probably not see too good of a return, so don't be surprised if such a post falls short like Homer Simpson at Springfield Gorge.
So, when are most people free to interact? Let's find out…
During office hours, a post nestled neatly in the middle of the working day to coincide with lunchtimes is a smart choice.
Many of us turn to our phones as a means of distraction during our lunch hours, whether its to catch up with the world, interact with friends or simply distance ourselves from the morning workload.
As such, a well-timed post that arrives during the hours of 11:00 and 14:00 to cover the varied lunchtime window can increase your likelihood of success dramatically.
This interval covers a wide margin of lunchtime windows, including those who take an early lunch and those who leave it late; however, it's better to post earlier and cover the whole spectrum than leave it late and risk missing part of your demo.
Outside of lunchtime, the next logical part of the day where people are free to relax, unwind and scroll aimlessly through reams and reams of social media posts is, of course, the evening.
With work in the rear-view mirror, the brief reprieve of the post-work downtime provides the working Brit with a few hours respite and the social media manager with a prime posting window.
For the clocking-off commuters, anywhere after 17:00 is a good place to start catching those idle thumbs during a home-bound public transport journey.
Meanwhile, catching your audience at home later in the evening when they are likely to be actively seeking entertainment is another great way to reach your audience.
Engagement figures tend to taper off as the night wears on so try to keep your evening post between the hours of 17:00 and 20:00.
As for the best days to post, the midweek frequently records the highest engagement figures and Wednesday in particular commonly emerges as a standout day.
Additionally, Sunday is also a prime candidate for pinnacle posting performance. The so-called day of rest, sees many of us reach for our phones in search of boredom avoidance.
Meanwhile, those that have made the most of their Saturdays will be looking to recover on the Sunday with a schedule to suit
For a lot of Brits, the road to recovery means lazing around scrolling through social media. Make the most of this social media upswing by scheduling your post to coincide.
While the above info is a great base to build upon in terms of social media engagement, it's important to remember that this info is merely a guide and not an exact science.
The truth is, there is no hard and fast rule to social media posting and engagement figures can be dependent on a whole host of factors, from the quality of the post to the content of the media you attach.
Even a quick Google search on optimal social media times will spit back a mixed bag of results, at times featuring completely contradictory advice from what you read elsewhere.
As such, the best way to approach social media posting is with a trial and error mindset. Keep track of your posts, interpret the results and find out what works for you and your business.
When you're scheduling your social media posts, try to bear in mind your target audience and think about their work patterns and living habits. This can have a big effect on engagement figures.
For example, a brand that targets stay-at-home mums is likely to have a drastically different posting schedule than a page that's aimed at an audience that works 9-5.
While it may seem obvious, you should time your posts to coincide with periods when your audience is likely to be online in order to ensure your posts reach the most people, get the most exposure and achieve the most engagement.
The better you know your audience, the better you can cater to their needs and adjust your content and posting times accordingly. Do your homework and get inside the mind of your target demo and you won't go far wrong.
For more social media tips or to enquire about the social media marketing services on offer here at Designer Websites, why not drop us a line today? Call now on 01446 339050 or get in touch online by clicking the button below.


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Frank Frazetta - Warrior Color Preliminary Original Art (undated). A sword-wielding warrior prepares to strike in this vibra...Click the image to load the highest resolution version.
DescriptionFrank Frazetta - Warrior Color Preliminary Original Art (undated). A sword-wielding warrior prepares to strike in this vibrant color preliminary painting by the legendary Frank Frazetta. The artwork measures 7.25" x 8.5", which is roughly twice the size of many of his color prelims. The figure pulses with coiled power, and the murky background lends the piece a somber air; a tiny masterpiece by Fritz. The artwork has been tastefully matted, and is in Excellent condition.
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I have done a preliminary analysis and the total of the hammer prices was $67,550. With BP, the final figure was $80,722.25. That is against the total insurance value of $34,785 or 2.32 x 'pre-auction estimate'. Incredible, really, so a big thanks.View More Testimonials
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Sutton Coldfield Constituency: Sutton Four Oaks, Sutton Mere Green, Sutton Reddicap, Sutton Roughley, Sutton Trinity, Sutton Vesey, Sutton Walmley & Minworth, Sutton Wylde Green.
Copyright © 2019. All rights reserved. This website is funded from Parliamentary allowances.
I'm not currently an MP, as Parliament has been dissolved until after the General Election on 12th December 2019. This website will not be updated during the election campaign and is for reference of my work when I was a Member of Parliament.
For ongoing casework you can contact me on 0121 354 2229 or email me here.


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New THROWDOWN Album Intolerance Streaming In Full Ahead of Release
eOne have just posted a full album stream of Throwdown's big comeback record, Intolerance which comes out this Tuesday. You can pre-order the sucka on Amazon.com right now.
In related news, our friends at Lambgoat have a pretty great interview with frontman Dave Peters explaining the band's absence and their comparisons to Pantera.


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Welcome to Iceland: What to Keep in Mind When Planning Your Trip to Iceland November 27, 2019
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3 Things to Check Before a Last-Minute Camping Trip November 19, 2019
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Your Guide to Standup Paddleboarding October 08, 2019
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At TravDevil, we believe that a life outdoors is a life well lived. We've been sharing our passion for the outdoors since 2009. Read our story
5 Outdoor Activities You Can Do Near Sacramento, CA
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Ask any Sacramento resident, and they will tell you that they feel fortunate to call Sacramento home. This is for a myriad of reasons, but one of the main draws for both residents and tourists alike would be some of the remarkable outdoor activities this town offers. Although it's hard to narrow it down, there are at least five outdoor activities that you can do near California's capital:
There is a whole host of camping opportunities near Sacramento. Lyon Local explains that these would include such options as at least a dozen different RV and tent camping areas and up to three dozen different campgrounds within a two-hour radius of Sacramento. Moreover, there are excellent opportunities for free camping throughout the region. Examples of this would include such places as Camp Pollock, Mama Marks Park, SacWest Park, Compound and Bear River Park, and Campground and Sacramento Bypass Wildlife Area.
Trail Rides
You might be surprised at how many opportunities there are for trail ranch rides throughout the state of California and not just near Sacramento. Vaquera Ranch points out that if you are looking for something closer to the Sierras, there is a handful of trail riding opportunities about an hour away from the Sacramento International Airport. These would include horse riding businesses that provide simple riding opportunities and also ranches that provide space for horse boarding as well.
Rafting and Tubing
Considering that Sacramento is the source for two different rivers, there are many opportunities for people who want to go rafting and tubing. You can either take part in this unique activity on the American River or the Sacramento River, and there are several different rafting and tubing companies with qualified guides to help you have the most amazing experience possible.
Considering that Sacramento is at the top of the Central Valley, you wouldn't think that there would be hiking opportunities near this city, but it's true. This area has many different hills, wetlands, parks, rivers, and hills. There's the South Fork American River Trail, which includes 25 miles available for hiking and opportunities for spectacular scenery along the way. The Quarry Trail is also an ideal trail for family members of all ages. Moreover, it has an interesting historical aspect as it was once used for limestone mining. Also, there's the Sacramento River Trail, which is not only great for hiking but is also a good trail for bird watching. There are even opportunities to spot a bald eagle from time to time. Any hiking enthusiasts know the importance of good shoes, so make sure you have the right ones for you.
GolfingAnother great thing about Sacramento would be the many golf courses that are available within quick driving distance of the California capital. These golf courses all echo the terrain of the Sacramento, which is very diverse. This leads to some unique golf courses in turn. For example, the Sierra View Golf Course is known for being extremely pristine and well taken care of. Moreover, this golf course is part of the Sierra View Country Club, which many visitors and members describe as being "warm", "welcoming", and "exceptional." This country club believes that they are so much more than just a list of amenities, but they are also a place to create fond memories and build friendships. In a sense, these and other area country clubs are a microcosm of the greater community of Sacramento.
As you can see, Sacramento has a lot of outdoor activities to offer both visitors and residents alike. We realize this is going to be a great place for you to find yourself and to invest in your own personal growth. Sacramento truly is an underrated diamond in the rough!
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Upcoming Events
We are always planning great store events for our wonderful customers. Be sure to check here often for updates or follow us on Instagram & Facebook. Please check out the events below & come join us! We would love for you to be part of the fun.
Jewelry by Michelle Trunk Show
Saturday, December 7th, 2019
11am -4pm
One of a Kind Semi-Precious Stone Jewelry. Made by a local women entrepreneur. Women supporting women in business.
Holiday Jewelry Trunk Show
Sun. Dec. 8th & Fri. Dec.13th
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Meet Sara, our NEW local Whitestone, NY jewelry designer.
Handmade jewelry include stones sourced all over the world. Affordable and unique. Sterling silver, Double dipped gold over stainless steel earrings, necklaces and bracelets.
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Spirit Circle with Psychic Medium Carla Blaha
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We're excited to welcome back Carla Blaha, renowned psychic medium and Intuitive to Pippy&Lily! Join us for an uplifting 2 hour Spirit Circle, guests sit in our friendly group atmosphere while Carla connects with your loved ones.
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text: Heath De Fount-Haberlin's 50th birthday gig will be at Peri's in Fairfax, California on either Friday, January 10, 2019. The band includes Heath De Fount-Haberlin on guitar/vocals, Lex Razon on drums and Kevin T. White on bass. There will also be some musical special guests! Heath will be cooking paella for family and friends as well!


text: The NICEIC has just has published the results of a survey which asked registered electrical contractors their thoughts on Part P of the Building Regulations. Around 1,500 completed the survey. The results obtained, which reflected a wide spread of electricians' views, are to be considered by the Government in their latest review of current Building Regulations. As discussed in previous posts, the effectiveness of Part P is currently being looked at and re-examined by the Office of the Deputy Prime Minister, who published the initial legislation back in 2005. This dictated that electrical courses graduates working domestically must have attended one of a specific range of electrical courses to become a qualified installer. They also had to be part of a Competent Person Scheme.There has been much debate regarding the changes needed, with most agreeing that Part P electrical courses should be amended to improve the current model. The responses received from the NICEIC survey support this view with 85% believing it should be retained. Three quarters of contributors said that there should be a pubic list of approved electrical installers for consumers to use, preventing unqualified electricians from carrying out domestic electrical work. One of the most telling findings was that half of the respondents have seen a marked increase in the standard of electrical work since Part P was brought in as an essential element of electrical courses.Other notable findings were that 75% of contributors said they wanted firmer action to be taken against those individuals who did not comply with the scheme. At present prosecutions are virtually non-existent. Finally, an important point the electrical courses graduates wanted homeowners to understand was which DIY tasks they can carry out themselves as opposed to those they need a qualified electrician to complete. Here at Access Training we feel that safety comes first and that, despite its numerous faults, Part P has been an undoubted success since its introduction, increasing the quality of the workmanship being carried out in people's homes.Here at Access Training we offer Part P electrical courses which will enable you to reach the industry required standard. If you require any further information regarding Part P electrical courses, or any of our other courses for that matter, please call 0800 345 7492 or email email@example.com.


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Hoffman Estates Schools - starts with J
The 50States Hoffman Estates school directory. Find Hoffman Estates , Illinois school addresses, phone numbers and other school info.
Go To: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
J B Conant High School
Students/Teachers: 2658 / 159
Grades: 9 - 12
700 E Cougar Trl
Hoffman Estates, IL 60194
John Muir Elem School
Students/Teachers: 661 / 33
Grades: Pre-School - 6
1973 Kensington Ln
Hoffman Estates, IL 60195


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XOMA Shines, PTGX Awaits Data, SELB Implodes, No Stopping NKTR
(RTTNews) - The following are some of the biotech stocks that made their way onto the Day's Gainers & Losers' list of November 7, 2017.
1. XOMA Corp.(XOMA)
Gained 18.31% to close Tuesday's (Nov.7) trading at $27.59.
News: The Company reported better-than-expected third quarter 2017 financial results.
Net income for the third quarter of 2017 was $26.3 million or $1.98 per share on total revenue of $36.18 million. Analysts polled by Thomson Reuters expected the Company to report a loss of $0.81 per share and revenue of $690 thousand. The increase in revenues for the third quarter of 2017 was due primarily to upfront payments received relating to the Company's license agreements with Novartis in August 2017.
In the third quarter of 2016, the Company had incurred a net loss of $12.5 million or $2.08 per share on revenue of $635 thousand.
2. Nektar Therapeutics (NKTR)
Gained 10.54% to close Tuesday's trading at $26.84.
News: The Company announced solid Q3, 2017 financial results.
Net income in the third quarter of 2017 was $60.9 million or $0.37 per share compared to a net loss of $43.2 million or $0.32 per share in the third quarter of 2016. Revenue in the recent third quarter surged to $152.9 million from $36.3 million in the comparable year-ago quarter.
Analysts polled by Thomson Reuters expected the Company to earn $0.17 per share on revenue of $114.62 million.
Revenue in 2017 included recognition of $127.6 million of the $150.0 million upfront payment from Nektar's collaboration with Eli Lilly & Co. for the development and commercialization of NKTR-358.
3. Celldex Therapeutics Inc. (CLDX)
Gained 10.08% to close Tuesday's trading at $2.62.
News: The Company reported business and financial highlights for the third quarter ended September 30, 2017.
Near-term catalysts:
-- Top-line data from phase IIb study of Glembatumumab vedotin in patients with metastatic triple negative breast cancers, dubbed METRIC, is expected to be available in the second quarter of 2018, but it could occur earlier or later based on the rate of events in the study. -- Enrollment in phase II portion of Varlilumab/Opdivo combination in cohorts of colorectal cancer, ovarian cancer, head and neck squamous cell carcinoma, renal cell carcinoma and glioblastoma are expected in the first quarter of 2018. --Initiate an open-label phase II study of CDX-3379 in combination with Erbitux in approximately 30 patients with recurrent/metastatic head and neck squamous cell cancer whose disease is resistant to Erbitux by year-end.
4. Protagonist Therapeutics Inc. (PTGX)
Gained 8.57% to close Tuesday's trading at $15.97.
News: The Company reported improved Q3, 2017 financial results.
Net loss attributable to stockholders narrowed to $4.82 million or $0.29 per share on collaboration & license revenue of $8.78 million. This compared with a net loss attributable to stockholders of $7.37 million or $0.87 per share and nil revenue in the year-ago quarter.
Near-term catalysts:
-- Final top-line results from a phase 1 clinical study of PTG-300 in normal healthy volunteers are anticipated this quarter (Q4, 2017). PTG-300 is being developed as a potential treatment for patients with chronic iron overload in rare diseases such as beta-thalassemia. --Interim futility analysis of phase 2b trial of PTG-100 in ulcerative colitis patients is expected in early 2018 - with top-line results anticipated for the second half of 2018. -- PTG-200, which is being co-developed by Janssen Biotech, for inflammatory bowel disease is expected to enter Phase 1 clinical testing this quarter.
1. Selecta Biosciences Inc. (SELB)
Lost 54.02% to close Tuesday's trading at $10.36.
News: The Company presented patient data from its ongoing phase II trial SEL-212 to treat severe gout patients and resolve their debilitating symptoms, including flares and gouty arthritis.
SEL-212 consists of SVP-Rapamycin co-administered with pegsiticase.
According to the Company, dosing of patients in the control cohorts receiving pegsiticase alone was stopped early due to a loss of clinical activity caused by the immunogenicity of the enzyme. Clinical activity was lost by Week 12 in the majority of patients receiving pegsiticase in combination with the 0.05 mg/kg dose of SVP-Rapamycin.
In mid SVP-Rapamycin dose cohorts, a majority of patients maintained clinical activity through Week 12 when receiving SEL-212.
Dosing of patients in the higher SVP-Rapamycin dose cohorts is underway.
The Company added that roughly 24 percent of patients receiving SEL-212 reported a gout flare during their first month of the trial. This is followed by a decline in flare rates during the remainder of the therapy. By comparison, 50% of patients reported a flare during the first month in the control cohorts receiving pegsiticase alone before treatment was stopped due to loss of efficacy and safety.
The Company plans to meet up with the FDA during the first half of 2018 and initiate its phase III program of SEL-212 in 2018.
2. Five Prime Therapeutics Inc. (FPRX)
Lost 40.90% to close Tuesday's trading at $25.86.
News: The Company will be presenting the first data from its phase 1a/1b clinical trial evaluating the immunotherapy combination of Cabiralizumab with Opdivo in multiple tumor types on Wednesday, November 8, 2017, at 8:00 a.m. (ET).
Jefferies analyst Eun Yang has commented that the "data are "not as strong as we like to see," but compares reasonably to chemo combo in second-line pancreatic cancer.
3. Veracyte Inc. (VCYT)
Lost 21.43% to close Tuesday's trading at $6.49.
News: The Company reported wider loss and lower revenue for Q3, 2017, and trimmed its revenue outlook for the year.
Net loss for the third quarter of 2017 widened to $7.05 million or $0.21 per share on revenue of $17.52 million. This compared with a loss of $5.64 million or $0.20 per share and revenue of $18.6 million in the year-ago quarter.
Analysts polled by Thomson Reuters expected the company to incur a loss of $0.23 per share on revenue of $19.55 million.
Looking ahead, the Company trimmed its 2017 annual revenue guidance range to $71 to $72 million from its prior forecast of $76 to $84 million range.
4. Voyager Therapeutics Inc. (VYGR)
Lost 19.11% to close Tuesday's trading at $13.38.
News: The Company has commenced an underwritten public offering of $75 million of shares of its common stock. The underwriters will have a 30-day option to purchase up to an additional fifteen percent (15%) of the shares of common stock offered in the public offering.
Veracyte NewsMORE
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First Team
Jackson Birtwistle, Jr. A, Radnor
Jake Morin, Jr. A, Garnet Valley
Mitch Lachman, Jr. A, Garnet Valley
Peter Garno, Sr. M, Haverford School
Ibo Pio, Jr. M, Strath Haven
Jack Spence, Sr. M, Springfield
Mac Costin, Sr. M, Haverford School
Gavin Burke, Sr. M, Haverford School
Collin Loughead, Sr. D, Episcopal Academy
Pat Clemens, Sr. D, Springfield
Ryan Niggeman, Sr. D, Haverford School
Nick Van Horn, Jr. G, Garnet Valley
READ: All-Delco Boys Lacrosse: Garno's standout season part of ongoing Haverford School lore
Second Team
Charlie Cunniffe, Jr. A, Episcopal Academy
Brennan McBride, Jr. A, Haverford School
Adam Salvaggio, Sr. A, Haverford School
Drew Brown, Sr. A, Radnor
Ethan Belville, Sr. M, Strath Haven
Danny Bradley, Sr. M, Garnet Valley
Jack Henderson, Sr. FO, Episcopal Academy
Ryan Culp, Sr. FO, Cardinal O'Hara
Quinn Chambers, Sr. M, Episcopal Academy
Sam Morin, So. D, Garnet Valley
Cole Schwartz, Jr. D, Radnor
Matt Chess, Jr. G, Episcopal Academy
READ: All-Delco Boys Lacrosse: Birtwistle, Morin had standout junior campaigns
Honorable mention
Archbishop Carroll: Andy Borkowski, Padraig Casey, Sean Kearney, Fynn McNulty, Zane Walsh
Cardinal O'Hara: Jake Cavanaugh, Chris Kirby, James Kutufaris, Jimmy Yocum
Delco Christian: Nadir Bryant, Cole Hines, Naim Robinson, Noah Thies
Episcopal Academy: Nick Bates, Rowan Brumbaugh, Gabe Furey, Max Strid
Garnet Valley: Hunter Baar, Aidan Berry, Max Busenkell, Sean Gallagher, Adam Oldrati, Bryce Stansfield
Haverford: Kyle Bennett, Jimmy Callaghan, Matt Davis, Andrew Lord, John Scheivert
Haverford School: Bobby Blewett, Sage Garito, Pearse Glavin, Jack Leary, Seamus McCloskey, Chris Tsetsekos
Interboro: Mikey Brown, Connor Evans, Nick Mormando, AJ Porreca, James Udowenko
Marple Newtown: Luke Jelus, Colin Ferry, Liam Ferry, CJ Lane, Marlon Weathers
Penncrest: Lee Feinman, Brennan Kaut, Ryan Matsinger, Robby McDonnell, TJ Sims, Shane Stevens
Radnor: John Austen, Pat Cullen, Archer Darrach, Jaden Goldstein
Ridley: Jake Bakey, Sean Hinchey, Brendan King
Springfield: Jeff Biancaniello, Zach Broomall, Jack Clark, Liam DiFonzo, Jim Donegan, Geo Dotsicas, Colin Hopkins
Strath Haven: Liam Carney, Matt Faggioli, Christian Mazur, Zane Mazur, Nicky Palermo, Vincey Palermo
Sun Valley: Gavin McGinnis
Upper Darby: Barkaat Ahdil, Christian Cucinotta, Davy Phosouvank-Chamrouenphorn
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Any master-crafter benefits from quality tools.
Painters create awe inspiring art with an assortment of brushes, a carpenter builds the house of their dreams with sturdy tools, and membership site owners can create profitable communities with a program designed to not only create content, but organize it as well.
Have you looked into using Scrivener since Part 1 of this series?
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by Snow Lake
Just another night in the homeless shelter
|The awkwardly spread blades of the ceiling fan rotate pointlessly, stirring the stale air of the small office. It is both cold and stuffy – the most unpleasant combination. My body becomes intimately familiar with the little love seat, its uncomfortable surfaces and unaccommodating curves. It is way too short for my long body, and if I try to take a nap, I invariably end up in a fetus position, with the neck twisted to one side. The dull blue color of the coarse fabric smartly conceals the dust, the stains, and the undreamed dreams of overnight staff's sleepless nights.
I check in with my other senses. Vision is the one least engaged. I try to keep my tired eyes shut. Sometimes, weird little flashes of light penetrate the curtain of the half-closed lashes. These must be the reflections on the walls thrown by the bizarre tri-dimensional flower performing its Brownian motion on the screen of the computer that purrs like a kitten crouching in the corner.
The feeble complaints of the PC are overpowered by the even buzz of the refrigerator full of antidepressants – most of the residents in this shelter are on the prescription medications. Worst of all, although it is three in the morning, the TV is still on in the living room, making distasteful inconsequential noise.
Today is a lucky day – the shelter ran out of powder laundry soap! Usually a huge tub of this disgusting stuff is placed near the door, to enable counselors distribute the cleaning substance to the clients, while the toxic pungent smells permeate the office. But, fortunately, we are out of the vile chemical, and, this night, my olfaction may relax.
There is really nothing to say about taste – I am hungry, as always in the middle of a sleepless night, and there is nothing to do about it. Although there are always leftovers in the kitchen, and people are cooking something throughout the night, it just does not feel right to eat at this hour. I will have to wait until five, when I can finally make a pot of coffee. Not that anybody prevents me from making it earlier – but five is morning, and the other day, and now it is still night.
Anyway, there is no time to relax on the short love seat, or to think about my aching senses. It is still night, and all the trials and tribulations of humankind are pouring into my little office. As a crisis call counselor and overnight advocate I seem to be responsible for all the injustices and pains of my fellow-human beings.
Suddenly the alarm starts to beep. I don't trust it. Something is out of order in this little machine. Still, I have to check it out. The display directs me to check the playroom window. I slowly shuffle their, stepping over toys and picture book. The window seems to be OK. I peep through the blinds, and find myself looking into a men's eyes. He is just as startled as I am, maybe more. A young guy, slightly built, with traces of acne – who said that batterers are supposed to be big and intimidating? He retreats to his car. In the light of a street lamp I managed to notice the license plate. As he hastily drives off, I return to the office contemplating whether to call the police now, or leave it until the morning.
The telephone rings. I pick up the receiver.
"Crisis line – how can I help you?"
I hear her breath on the line. She calls every night at this hour. She was a resident a couple of months ago. We heard that her newborn baby died, presumably as a result of abuse she suffered during pregnancy. She needs mental help – but she has not insurance. Not even Medicaid, because she is homeless.
"Hello, who is there?"
Finally she answers, hesitantly, almost inaudibly: "I don't think I want to talk to you. I need to talk to Betty."
Betty never works nights, as she knows it, but she only calls at this hour.
"Betty is not here, but I would be glad to talk to you. Are you safe right now?"
Yes, she says, she is safe, but could she please talk to Betty?
Usually we carry on this conversation for at least half an hour, but this is not going to happen today.
I hear a piercing scream from the second floor, which makes me drop the receiver. With my heart sinking, I grab the "Scout" phone and run upstairs.
A Latina woman, whose name I don't know, stands at the doorway to the common bathroom, and pointing her shaking hand yells something in Spanish.
I glance inside. The first thing that comes to my mind is: who allowed children to play with paint in the bathtub? Then I realize it id blood. Then I see him – her – this person.
I saw her about the shelter a few times, but never had a chance to talk. Her name is Chris – Christa – she is a male to female – she is a woman, of course, otherwise she would not be here in the battered women shelter.
But how can there be so much blood in a person's body? I look at Christa's lifeless hand with slashed wrists, her long blond hair floating in the water now has a pinkish hue. I notice a new stubble on her cheeks.
My senses must be all muddled – I hear patter of little feet, and from the corner of my eye notice a couple of toddlers, naked but for the pull-ups, with shrieks of merriment running down the corridor. Am I in the middle of some surrealistic horror movie, or just doing my $12 an hour relief counselor job?
For some reason, the site of the kids brings me back to life. I even recall some of my limited Spanish. "Tus niños! Allí!"
I send the mother after her children and look at Christa. He face is white, but she opens her eyes and looks at me with a mixture of defiance and relief.
"That's OK, sweetheart, that's OK. All will be fine," – I murmur, looking for something – anything – clean to press to the wound. At the same time I push the automatic dial button on the "Scout." The paramedics are frequent guests in this house, and there number is programmed in every phone.
I cast a quick glance around to make sure that the blade, or whatever she used to cut her wrists, is not anywhere within her reach, then thrust a roll of paper towels on her wound.
"Here, hold on to this," – and tumble down the stairs to open the door to the paramedics.
As soon as they are gone with Christa, I rush back upstairs with two bottles of milk. The terrified mother holds one of her kids, I hold another, while we rock them to sleep.
"C'est bien, tout sera bien," – by now my Spanish is all gone, but French seems quite appropriate under the circumstances.
In 20 minutes all the three of them are miraculously asleep. I look at the watch – it is five. Time to make that pot of coffee!
Downstairs, first of all I tiptoe into the living rooms. Both of the late TV – watchers are fast asleep on the couches. I turn off the TV – what a bliss!
First rays of summer sun penetrate through the blinds, a reminder of bright happy life that exists out there.
While the coffee is percolating, I make and inspection of a large box of old Starbucks goodies donated every week, and finally choose a cranberry scone.
My breakfast in hands, I return to the office. The next hour is usually the most quiet in the shelter. Before the change over I will have plenty of time to complete clients' records and get ready for my daytime job.


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Stefan Hohne
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[Chapter] Stefan Hohne (2015) How to Make a Map for the Hades of Names: The New York City Subway Map Wars of the 1970s. In: Cultural Histories of Sociabilities, Spaces and Mobilities (pp. 83-98).
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5 Common Winter HVAC Problems
Regular servicing of your HVAC and a deep clean once a year is recommended. Why? Well, it's simple. Regular maintenance keeps your system free of
Regular servicing of your HVAC and a deep clean once a year is recommended. Why? Well, it's simple. Regular maintenance keeps your system free of
With fall underway and the holiday season already warming up in Athens, GA, it's time to get things toasty inside your home, too. We'll give
The fall season brings Georgia football, apple picking, hayrides, and backyard barbecues. It also means hot temperatures will linger for a while longer, requiring an
In the heat of the Athens, GA summer, having your air conditioner break down is the absolute worst thing that could probably happen. You'll want
Whether you've just moved to Athens, GA or have called Athens home your whole life, there's no mistaking the fact that during the summer months
Did you know that your air conditioner is actually transferring heat elsewhere to cool the air before pumping it into your home? Rather than cooling
Have you ever experienced an HVAC breakdown in the middle of summer? If you have, you'll understand how often we take these systems for granted.
Air Conditioner Rattling Can Be Caused By A Variety of Factors… A good air conditioning system is the best way to stay comfortable in the
Spring – is there any more beautiful time of the year? We get to put away all of our warm winter coats and start enjoying
Dealing with a heat pump that has shut down due to freezing temperatures. Heat pumps typically freeze in cold weather, particularly if the area where


text:
Contemporary painting : Movements of colors.
Made in Posca (Uni / style acrylic paint) on wooden frame covered with bleached linen. (Fade color gradation)
Protection : glossy spray paint.
Approximately 140 hours of achievements.
To see a video preview of this work, visit : https://www.youtube.com/watch?v=8JKjKDYkOas
Format : 55 cm X 46 cm X 2 cm.
Diagonal : 71.7 cm.
Weight of the work : 0.685 kg.
Date of completion : 12/2016.
Work signed.
Certificate of authenticity provided.
Contemporary painting : Color movements


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Chemotherapy may cause breast cancer to spread, alarming research suggests. The commonly prescribed chemo drugs paclitaxel and doxorubicin cause breast tumours to release proteins that then circulate in the blood until they reach the lungs, triggering the disease's onset in a new part of the body. When scientists blocked this protein in a lab model, the cancer did not spread. They hope their findings will help make chemotherapy more effective. Doxorubicin (stock image) is one of two commonly prescribed breast-cancer chemo drugs the scientists analysed. When put in an experimental tumour model, doxorubicin caused breast tumours to release sacs containing a protein that was then circulated to the lungs The study was carried out by the Swiss Institute for Experimental Cancer Research and led by Professor Michele De Palma, head of the lab. Chemotherapy is often given to breast-cancer patients before surgery to shrink their tumours and make them easier to remove. Known as … [Read more...] about Chemotherapy may cause breast cancer to SPREAD: Two commonly used drugs encourage the disease to develop in the lungs
Centre for cancer drug discovery
Thousands of breast cancer patients could be spared weeks of gruelling radiotherapy with a five-day course of a less aggressive treatment
Thousands of women with breast cancer could be spared weeks of radiotherapy after scientists discovered a new targeted approach, taking a fraction of the time, is just as effective. A five-day course of partial breast irradiation is far less gruelling than traditional radiotherapy, which bathes the whole breast and takes up to six weeks of daily sessions. A ten-year trial of the targeted approach has found it is just as effective as the traditional technique. And experts say the less aggressive method is likely to come with fewer side effects such as scarring, sensitivity and a change in breast appearance. A five-day course of partial breast irradiation is far less gruelling than traditional radiotherapy, which bathes the whole breast and takes up to six weeks of daily sessions More than 38,000 women undergo radiotherapy for breast cancer in England each year. The procedure is given after women have a tumour surgically removed, and is designed to eradicate all remaining cancer cells … [Read more...] about Thousands of breast cancer patients could be spared weeks of gruelling radiotherapy with a five-day course of a less aggressive treatment
Smart blood test can identify whether women with aggressive breast cancer will respond to precision drugs, study finds
A smart blood test can identify whether women with advanced breast cancer will respond to targeted drugs, scientists have found. Researchers found the test can detect traces of DNA shed by tumours, allowing doctors to spot if a patient's cancer has genetic mutations. These mutations can be attacked with precision drugs. Experts say the discovery paves the way for greater use of personalised medicines. Researchers at The Institute of Cancer Research in London trialled the test on 1,000 women with advanced forms of the disease. They found it was as accurate as biopsies 95 per cent of the time. Biopsies can be painful and getting results back takes time. It could spell the end of biopsies, which doctors rely on before offering experimental drugs to try and halt the spread of the disease. Charities have said the new liquid biopsy, as it is known, is 'exciting' and a 'huge step' forwards for treating breast cancer. Experts hope this will spell an end to the … [Read more...] about Smart blood test can identify whether women with aggressive breast cancer will respond to precision drugs, study finds
Older women can halve their risk of breast cancer with new hormone therapy pill
Older women can halve their risk of breast cancer by taking a new hormone therapy pill, research shows. The female hormone estrogen can help tumours grow so taking a drug to block it reduces the risk from deadly cancers. The most popular version is tamoxifen for which 700,000 prescriptions are written on the NHS each year but a new version has been found to better halt tumours. The drugs are offered to women who have either had breast cancer or are at a high risk of it because of their family history. A study of almost 4,000 women around the world published in the Lancet found anastrozole improved long term protection for those who take it for five years and then stop. Up to seven years later breast cancer incidence was 49% among the half randomly assigned to it compared to those given a placebo. This is significantly better than the 28% decrease recorded for women given tamoxifen. British scientists say the new drug, prescribed under the brand name Arimidex, should become the … [Read more...] about Older women can halve their risk of breast cancer with new hormone therapy pill
A single pill a day 'slashes odds of breast cancer in women at high risk'
A SINGLE pill a day can slash the odds of breast cancer in women at high risk, a study says. Those taking anastrozole over five years were 61 per cent less likely to develop the disease, tests revealed. Seven years after coming off the medication, also known as Arimidex, they were still at 49 per cent lower risk. The pill should be the "drug of choice" in most cases for post-menopausal women at high breast cancer risk, say experts. It works better than popular alternative Tamoxifen which has been shown to reduce risk by 28 per cent. Tamoxifen also has more side-effects than anastrozole including higher heart disease risk, mood swings and a loss of sex drive. Both are hormonal therapies in tablet form. Study leader Professor Jack Cuzick, of Queen Mary University of London, called the results "exciting".Speedy test leapA BLOOD test could transform treatment for women with advanced breast cancer.The check can quickly spot cell mutations driving the disease. Doctors … [Read more...] about A single pill a day 'slashes odds of breast cancer in women at high risk'


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- Business Spotlight – The Corning Chamber of Commerce's spotlight is on the pet grooming business, Waggs, located at 1920 Solano St. Jackie Chapman opened Waggs three years ago with the urging from her friend Kelly. Waggs is open Tuesday through Thursday from 10 a.m. to 2 p.m.. Kelly not only does grooming at the shop and competes in dog shows around the country, she also gives handling lessons and dog training. She has been in Corning 8 years. Jackie, the owner, also moved to Corning 8 years ago from Pleasanton. She and family have 20 acres of land where they raise llamas and other animals. Waggs is known for its friendliness and their love for animals. If you would like to make an appointment for grooming, call 824-6089.
- Corning in the Evening – The chamber would like to thank U.S. Bank for hosting the monthly get together last Thursday. There was a nice group of about 35 people who enjoyed visiting with one another and having the opportunity to introduce themselves and make announcements about their business or organization.
Kristen Behrens from St. Elizabeth Community Hospital announced the "Fly Girls" event at Rolling Hills Casino Resort on May 2. Casting for Recovery provides fly fishing retreats around the United States for women who have or have had breast cancer.
Tickets are $45 which includes breakfast, fly fishing clinic, lunch and gift.
- Benefit Concert for Rodger's Theatre – Sunday there will be a benefit concert to raise funds for Rodger's Theatre, 6:30 pm, at the Corning Veteran's Memorial Hall, 1620 Solano St. Transfer, a popular band from San Diego and Holy Rolling Empire from Tucson, Arizona will be performing as well as a local band, Olive City Rebels.
Tickets are $6 and are available at the Chamber of Commerce, Marco's Pizza and from members of the Friends of the Theatre Committee.
For more information, please call the chamber at 824-5550.
- Celebrate Administrative Professionals Week – Wednesday, April 22, from 7:30-11 a.m. at the Red Bluff Community Center, the Job Training Center is hosting a special morning for administrative professionals.
This is an opportunity to honor your support staff, from receptionist to office managers, customer service representatives and clerks.
Space is limited, and registration is required to attend. The cost is $25 and includes a catered breakfast and raffle prizes from local vendors. To register please call 529-7000.
The Growing Corning column is prepared and submitted by the Corning Chamber of Commerce. www.corningchamber.org