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Safest Betting Sites – Home Of The Best Online Sportsbooks
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Sports betting has been around forever. The advent of the internet has taken sports gambling to new heights. The list of online betting sites worth checking out has grown in recent years. In our ranking, we include Bovada, Sportsbetting or BetOnline. You can track the sports betting odds across the entire web, as the Las Vegas betting boards no longer have the monopoly on these. In today's world, the betting markets are worldwide and changing every second.
Sports betting has different levels of legality throughout the world. In most Asian countries, it's expressly illegal. In most of Europe, it's regulated and legal. In the United States, it's only legal to bet on sports in Nevada in addition to New Jersey. Mississippi, West Virginia, New Mexico, Pennsylvania, and Rhode Island which have legalized sports betting in some form as of Dec. 2018. Yet, sports betting is widespread across the country at online sportsbooks and unregulated corner bookies.
Is Betting Sports Online Legal?
This is a question that few sites answer, other than to say that bettors don't have to worry about law enforcement when they place a wager at an offshore sportsbook. That is because the real issue is enforcement. While the act of operating an online sportsbook inside the US across state borders is a federal offense, betting sports online falls into a gray area. So betting at Sportsbetting or Liveryman Harmony 1.0 Wide Replacment Blade - FREE P+P is safe.
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Weigh the pros and cons of technologies, products and projects you are considering.
Weigh the pros and cons of technologies, products and projects you are considering.
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subset: commoncrawl


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Teas are a great way to get the benefits of sage all you need to do is steep one teaspoon of sage in a cup of water for about 10 minutes. You can also make a pretty awesome sore throat reliever by combining sage and thyme. Take an ounce of both grind them, and cover them with 16 ounces of apple cider vinegar. Be sure to shake it periodically and let it sit for ten days before using.
Verma, N., Meena, N. K., Majumdar, I., & Paul, J. (2017, December 30). Role of bromelain as herbal anti-inflammatory compound using in vitro and in vivo model of colitis. Journal of Autoimmune Disorders, 3(52). Retrieved from http://autoimmunediseases.imedpub.com/role-of-bromelain-as-herbal-antiinflammatory-compound-using-in-vitro-and-in-vivo-model-of-colitis.php?aid=21395
I use R.C. in cold mist disfuser as well on bottoms of feet, chest and neck. I would take a detox bath (1c if espon salt mix with 1table spoon of bakingsoda and 5 drops of ginger oil 10 drops of lavender add 1 cup of ACV put in hottest water inyub you can be in stsy in at least 26 min. R.C. has four types of Eucalyptus in it plus myrtle,pine, lavender, cypress, spruce,peppermint, marjoram. It is sold by youngliving for under $11 love it!
The most significant use of cinnamon is to treat diabetes, take 1 teaspoon of powdered cinnamon daily to help level out blood sugar levels. Capsules of cinnamon can also be found the dosage varies but generally 1-6 grams of cinnamon capsules per day spaced out is a good amount. A nice little way to substitute cinnamon sugar would be to combine one cinnamon stick freshly ground with 6 teaspoons of stevia. This is great for adding to toast, oatmeal or fruit.
If you're looking to use neem as a skin toner, simply boil around 20 neem leaves in half a liter of water, once the leaves become soft and discolored and the water turns green you can strain them. Keep the liquid in a bottle and when you're ready to use it just take a cotton ball wet it down with the liquid and apply it to your face. This will prevent acne and blackheads from occurring. You can also use it to prevent skin infections simply by adding a little to your bath water.
The reason that patients using alternative treatments die sooner may be because patients who accurately perceive that they are likely to survive do not attempt unproven remedies, and patients who accurately perceive that they are unlikely to survive are attracted to unproven remedies.[17] Among patients who believe their condition to be untreatable by evidence-based medicine, "desperation drives them into the hands of anyone with a promise and a smile."[19] Con artists have long exploited patients' perceived lack of options to extract payments for ineffectual and even harmful treatments.[19]
Hippophae rhamnoides Sea buckthorn The leaves are used as herbal medicine to alleviate cough and fever, pain, and general gastrointestinal disorders as well as to cure dermatologic disorders. Similarly, the fruit juice and oils can be used in the treatment of liver disease, gastrointestinal disorders, chronic wounds or other dermatological disorders.[90]
Hi Lydia you'll never have AMONIA because it's what you clean floors with but people tent to confuse it, as you did with NEUMONÍA. I also have a cough and bought at WALMART a ginger tea made in Australia which seems to be stronger than others when you don't have ginger root handy. So I added honey. Always part of our staples and added lemon juice, always also part of our staple and drank tea hot after I let it steep in covered cup and I'm getting better. It beats taking meds that have horrible side effects.
Eating a clove or two of fresh garlic a day may indeed keep the doctor away, in part because it has immune-boosting, antibacterial, antiviral, and anti-fungal effects. Many of garlic's therapeutic effects are derived from its sulfur-containing compounds, such as allicin, which are also what give it its characteristic smell. In general, garlic's benefits fall into four main categories:
Magaziner Medical Center in Cherry Hill is run by Allan Magaziner, D.O., P.C. He mainly treats prostate, breast, lung, and bowel cancers; but he also treats Alzheimer's, multiple sclerosis and heart problems. He uses oral and IV vitamins, minerals, amino acids, oral botanicals, herbs, enzymes, homeopathic remedies, chelation, and detoxification. His website is www.drmagaziner.com. 856-424-8222
Holistic Resource Center in Agoura Hills, CA - Dr. Alan Schwartz, MD. and a number of holistic practitioners including a chiropractor, naturopaths, homeopath, and a massage therapist. They can do bio-electrical screening, NAET allergy removal, and they provide nutritional support including IVs, diet programs, Poly MVA, PC SPES, homeopathy, and more. 818-597-0966 or fax 818-597-8668.
We live in a world where prescription medicine is getting more and more expensive as well as controversial. Alternative medicine is gaining momentum and with good reason! The same is true for treatments for diabetes type 2. You have therapies that can reverse diabetes through lifestyle and diet changes, natural supplements that can help stabilize blood sugar levels, and also herbs that lower blood sugar. Not only are these alternative therapies safer, but they are also easier on your pocket, on your body and mind.
These seeds, used in Indian cooking, have been found to lower blood sugar, increase insulin sensitivity, and reduce high cholesterol, according to several animal and human studies. The effect may be partly due to the seeds' high fiber content. The seeds also contain an amino acid that appears to boost the release of insulin. In one of the largest studies on fenugreek, 60 people who took 25 grams daily showed significant improvements in blood sugar control and post-meal spikes.
According to the toxicity and disease model, cancer forms when toxicity builds up to the point that it spills over from the blood to the space between the blood and the cells called the extracellular matrix and then finally spills over into the cell itself and enters the nucleus of the cell where the DNA and genetic material are made. When toxins enter into the nucleus the cell has one final attempt to survive, it dedifferentiates into stem cells to try to adapt to a toxic, hostile environment. The stem cell can change into any cell type and also grow very rapidly.
Valerian is another great herb that's used as a sedative. Valerian (Valeriana officinalis) soothes anxiety and is often used as a sleep aid. Commonly doubled up with California poppy, it makes a powerful, but gentle sedative. Valerian can interact with medications and shouldn't be used without first checking with your doctor. Pregnant and lactating women shouldn't take valerian.
Viburnum tinus Laurustinus V. tinus has medicinal properties. The active ingredients are viburnin (a substance or more probably a mixture of compounds) and tannins. Tannins can cause stomach upset. The leaves when infused have antipyretic properties. The fruits have been used as purgatives against constipation. The tincture has been used lately in herbal medicine as a remedy for depression. The plant also contains iridoid glucosides.[192]
Saw palmetto is a very popular herb with men over 40. It is often used to treat Benign Prostatic Hyperplasia (BPH) and it's symptoms, like painful urination and the need to urinate frequently. Another popular use of this herb is to treat male pattern baldness by reducing the body's levels of dihydrotestosterone (DHT). Too much DHT is believed to be what causes hair loss.
Paul V. Beals, M.D. also runs a clinic in Laurel. He treats Most nonmetastatic cancers and various degenerative diseases. including heart disease, diabetes, lung disease, multiple sclerosis, and fibromyalgia. He uses diet, metabolic nutrition, IV & oral vitamins & minerals, immunotherapy, laetrile, megavitamins, DMSO, hydrogen peroxide, BCG, and chelation. Contact info: (301) 490-9911.
Cancer is characterized by unrestrained proliferation and loss of organization, a process that is intimately linked to, and controlled by, reciprocal signaling between the genetically altered tumor epithelium, the stroma, the components of the basement membrane and inflammatory mediators. Much work has been done to characterize the genetics of cancer cells. In this review, we describe the experiments that have been performed, which point to the significant role of the tissue microenvironment in the developmental regulation of normal and neoplastic cells. Using a variety of model systems, the works of a number of laboratories have converged on a hypothesis where the correction of 1 or 2 signaling defects can revert tumor cells to a normal phenotype, both in vivo and in culture, even when the tumor cells possess multiple genetic and epigenetic lesions. This paradigm has been successfully used to treat acute promyelocytic leukemia, and it remains the task of biomedical researchers to identify additional targets for the reversion of other human malignancies.
Also a popular remedy for sore throats, salt water can ease the discomfort caused by a cough the same way it helps a sore throat-through osmosis. When the concentration of salt is higher outside of the cells in your mucous membranes, water flows out of the cells to balance everything out. When water leaves the cells, swelling goes down, and discomfort is decreased. If you have a cough that happens to come along with inflamed tissue, this is a good route to take. It can also help dislodge any phlegm that's hanging out and allow you to expel it easily.
Accent on Health in Lake Worth is run by Sheri W. Pinsley, D.O. They treat most cancers, chronic fatigue, immune suppressive diseases, candida, MS, Parkinson's disease, and chronic pain. They use intravenous treatments including chelation, vitamins and minerals, and hydrogen peroxide; nutritional counseling; stress management; and lifestyle modifications. Phone: (407) 547-2770.
Even with all these remedies, your body will struggle to recover from that annoying cough without proper rest. Once the worst symptoms of a cold or flu have worn off, many people get straight back to their busy lifestyle, which is why coughs can linger for so long for many people! Take things easy for a week or two and make sure to get your 8 hours sleep every night.
We live in a world of cancer causing products. They are in conventional food, the water, the air, in our clothing, our automobiles, our homes, the office equipment we use, and in the phones that we use for communication. There is great wisdom in taking reasonable precaution against the factors that can contribute to cancer formation. Sometimes an individual factor may not be a serious risk, but when many factors are combined, they could put a high level of stress on your body and open the door for cancer growth. There are many other factors that could contribute to cancer growth, but the items listed here will be a good starting point.
Hi. Back 12 months ago i had the miller fisher virus have been going on not to bad really been doing some work etc! Just lately been feeling like got a cold coming which i'm told is normal with this virus, the only thing is i've got this niggling chesty cough with fleum which is hard to move. Can anyone recommend anything herbal and safe i can use! Many thanks.
Robert Jay Rowen, MD has moved from Alaska to Santa Rosa, CA. You can reach him at 707-571-7560. He treats most forms of cancer, as well as treating chronic pain, immune dysfunction, allergies, and cardiovascular disease. The main therapies he uses includes: IPT therapy, chelation, bio-oxidative, nutrition, herbs, acupuncture, immune therapies, vitamin C, vaccines, and detoxification. He is not using laetrile in California. We understand he enjoys treating later stage cancers. His website is http://www.doctorrowen.com, and his email is firstname.lastname@example.com.
There was a clinical trial conducted at Department of Biochemistry, Postgraduate Institute of Basic Medical Sciences Madras, India that studied 22 patients with type 2 diabetes. It reported that supplementing the body with 400 mg of Gymnema Sylvestre extract daily resulted in remarkable reductions in blood glucose levels, hemoglobin A1c and glycosylated plasma protein levels. What's even more remarkable is that by the end of this 18 month study, participants were able to reduce the dosage of their prescription diabetes medication. Five were even completely off medication and attaining stable blood sugar levels with Gymnema Sylvestre supplementation alone.
Verma, N., Meena, N. K., Majumdar, I., & Paul, J. (2017, December 30). Role of bromelain as herbal anti-inflammatory compound using in vitro and in vivo model of colitis. Journal of Autoimmune Disorders, 3(52). Retrieved from http://autoimmunediseases.imedpub.com/role-of-bromelain-as-herbal-antiinflammatory-compound-using-in-vitro-and-in-vivo-model-of-colitis.php?aid=21395
The Gerson diet is a cleansing diet. It is based on the premise that a person who has cancer has very high levels of toxins in the body and these need to be removed in order for the cancer to be healed. It uses certain combinations of fruit and vegetable juices, and frequent enemas. People using the Gerson diet will consume specially formulated vegetarian meals, large amounts of fruit and vegetable juice, and 4 or more coffee enemas per day. It originally included daily consumption of raw liver juice, which has been recently removed from the diet. Some alternative healthcare providers believe that the original success of this therapy was linked to the inclusion of raw liver, and it should be included to obtain the full benefit of the therapy.
Chamomile is most popular in tea form for use to calm upset stomach and help support restful sleep. Germany's Commission E (a government organization) has even approved the use of chamomile for reducing swelling on your skin and fighting bacteria. Chamomile is a powerful anti-inflammatory that also has antibacterial, anti-spasmodic, anti-allergenic, muscle relaxant, and sedative properties. It is used to treat psoriasis, eczema, chickenpox, diaper rash, slow-healing wounds, abscesses, and gum inflammation,13 and according to Herb Wisdom may also be useful for the following conditions:14
Also known as pot marigold or poet's marigold, calendula is different than the common marigold that's usually seen in gardens. Unlike the common marigold calendula is edible and has very little scent. During medieval time in England the calendula herb was commonly used in stews, syrups, and breads. Calendula is also rather easy to start from seed and is able to adapt to many growing conditions making it an ideal herb to grow. The herb is found in many gardens all over the world for subarctic to tropic regions. Now let's take a look at the key medicinal uses that make calendula such a prized herb to have.
Over several decades, our understanding of the pathogenesis of neoplasia has been advanced tremendously. Many oncogenes and tumor suppressor genes have been identified and characterized, and it is usually accepted that cancer is a genetic disease. Nevertheless, it is beginning to be appreciated that the interrelationships between the tumor epithelium and the tissue microenvironment play a critical role in tumorigenesis. It has been demonstrated the ability of the tissue microenvironment to control malignancy and the mechanisms of tumor initiation, progression and regression.
Throughout his career, Dr. Weil has recommended herbal remedies far more often than he has prescribed prescription drugs and has said that he hasn't seen a serious adverse reaction to any of the herbal remedies he has recommended. However, because of the many unsubstantiated claims made for herbal remedies, and because the market is not well regulated, he recommends that consumers follow these guidelines:
^ Vickers A, Zollman C, Payne DK (October 2001). "Hypnosis and relaxation therapies". West. J. Med. 175 (4): 269–72. doi:10.1136/ewjm.175.4.269. PMC 1071579. PMID 11577062. Evidence from randomized controlled trials indicates that hypnosis, relaxation, and meditation techniques can reduce anxiety, particularly that related to stressful situations, such as receiving chemotherapy.
Thyme is a fragrant herb that makes a wonderful addition to your cooking, in part because it is rich in antioxidants. Thyme contains health-boosting flavonoids including apigenin, naringenin, luteolin, and thymonin, and has been shown to protect and increase the percentage of healthy fats found in cell membranes. As reported by the George Mateljan Foundation:12 "In particular, the amount of DHA (docosahexaenoic acid, an omega-3 fatty acid) in brain, kidney, and heart cell membranes was increased after dietary supplementation with thyme."
Over the years, I have been given a lot of different advice as well, so when I heard about Dr. Budwig's protocol I too was very skeptical, until I tried it. Numerous, independent clinical cancer studies published in major medical journals world-wide confirm Dr. Budwig's findings. Over 40 years ago, Dr. Budwig presented clear and convincing evidence, which has been confirmed by hundreds of other related scientific research papers since, that the essential fatty acids were at the core of the answer to the cancer problem.
Whenever this seasonal fruit is available in the market, try to include it in your diet as it can be very effective for the pancreas. Else you can make a powder of dried seeds of Jambul fruit and eat this powder with water twice a day. This fruit is native to India and its neighboring countries but you can find it at Asian markets and herbal shops.
Mistletoe therapy is the most frequently used complementary treatment in cancer patients in Germany and Switzerland. Iscador was first used for cancer therapy in 1922 by Rudolf Steiner and Ita Wegman based on anthroposophy. (Anthroposophical medicine views the occurrence of cancer, or any illness, as a disease that involves the whole human being, physically, mentally and emotionally.)
It comes as a surprise to many that clove is actually a flower bud, these buds have to be picked at just the right time. Before flowering the buds will turn a deep red and this is the ideal time to harvest your clove. Clove buds come from an evergreen bush with vibrant pink flowers and purple berries. The clove plant does best in warm and humid regions. The earliest written record of the use of clove as a medicinal herb is by the Han Dynasty in China around 300 B.C. Like cinnamon clove was a prized spice and once rivaled the value of oil. Now let's take a look and see what some of the key medicinal properties of clove is and how we can use this herb.
American ginseng is an adaptogen. An adaptogen is a substance which is good for the body in general and protects against stress of all types. This type of ginseng has been used to strengthen the immune system, increase strength and stamina, treat digestive disorders, treat diabetes, treat ADHD and as a general tonic for wellness. Many people believe that the best American ginseng comes from the state of Wisconsin in the U.S. American ginseng is considered a cooling ginseng, where Korean ginseng has a more warming effect on the body.
When we realize that fear is controlling us, we can turn away from the grip of conventional cancer treatment and make other choices. Some people turn to alternative cancer treatments after it has become clear that conventional treatments are not working. Other people just skip conventional treatments altogether and go directly to safer alternatives.


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What is going on with Eugenia Cooney? Live Psychic Readings at https://www.twitch.tv/antphrodite Book a Private Tarot Reading at https://www.antphrodite.com/readings/ Since the Shane Dawson interview/video, Eugenia Cooney has been the talk of the town. What's headed in store for her? And what about her and her mom's dynamic? Watch my psychic tarot reading on Eugenia Cooney to see what allegedly could have happened. ☆★ LIVE PSYCHIC READINGS https://www.twitch.tv/antphrodite ☆★ BOOK A PRIVATE TAROT READING FROM ME https://www.antphrodite.com/readings/ ☆★ VIEW ALL MY CELEBRITY PREDICTIONS: https://www.antphrodite.com/category/celebrity-readings/ ☆★ WEEKLY HOROSCOPES: https://www.antphrodite.com/category/weekly-horoscopes/ ☆★ FOLLOW ME ON SOCIALS: Twitch: https://www.twitch.tv/antphrodite Twitter: https://twitter.com/antphrodite Instagram: https://www.instagram.com/antphrodite/ Website: https://www.antphrodite.com/ These are for entertainment purposes only #EugeniaCooney #Psychic #shanedawson
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Highway 10 E
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Clinton Market has very reasonable pricing. Easy to get in to just off the freeway. They have a small deli Great chicken & jojo's. you don't have to wait in line very often for fuel or check out.4


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Self Closing Double Swing Gates
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Sorry that I was skipping through the video I had to go to bed soon in like 10 15 minutes
Done 👇
Team Damien and teen Bianca 😅😂😂
2019 anyone
Damien is too hyped
You should donate the money to a homeless person
Pickle are a disgrace to vegetable
14:12 and 11:34 are the funniest Damien not the prince of prancing he the 👑
Do your surgry fill better
What number to put the toaster on
i love you You guys
Each butter is have a stick of butter
Team biaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaanca
Team Biannnnnnnnnnnca 🤘🏾❤
Haha you got him 😅😅😅
I would have pulled a strap on her ah
Send me a iPhone 11 you know you want to
You were supposed to use only 3 sticks of those butters
Damien and Bianka I like your videos of another one like this make parts to and your videos or a stream Lee on Millville and make some more of these videos and when you make a make you a very
Damien Bianka I love you video may you please make another another video Lee and may you make one that's very talented and I am coming down the To Bianka I see the nicer one out again
Damian is annoying
Orlando Florida
I can,t breathe his face
I use my phone as my alarm clock.
i love you Biannca pray for nova
His face tho
Post notes turned on
I find this video very offensive bc they think just bc they got money they could brag about having expensive gifts
Damian face to the puzzles lol!!! I was bussing out laughing
You need to pray before you eat
I use my phone
0:44 - 0:57
You need some cinnamon
I love these kid of videos the bop it part Bianca was doing mad good I was laughing at Damian score compared to hers lol!
I love this channel wish I can meet you all
"My stomach hurt now "🤣🤣🤣
"I wanna watch tv"😂😂😂😭😭🤣
Your going to be ok ;(
Can i please have a ps 4 For my brother his name is jose
Can you do a giveaway Nintendo switch lite
Mild is not hot at all
I turned the post notification on🤣!!!
Do they know green apples are sour
Turned bell 🔔 love you guys 🙏💖❤
I don't use a alarm clock
Buy foods
Post notes turned on
Turned bell nontoficatopns love you guys god bless you 💖🙏
My iPhone
I love your tree
I di
I love your videos😍😍😍😍😇😇😏
There's a lot you don't no about me and b dad is smashing b
I use my phone
Followed your FB page!♥
They both got lazy eyes or sumn 😩👀
Hey I'm loyalty and I had dress for 4years I cut it today I look good
I use my iphone
Both hey guess can give a way stuff on USsel I love you guys
Happy birthday Bianca
Biannac team all day
She sexy
They both 🔥
U pray before you eat
when damien tryed to take of his shirt thogh 4:42
My phone
His head weigh 200 on its own 😂😂
I love your v
Dude with the gray sweatpants hungry😂😂
Are you at amry Walmart
You cracked my phone screen I'm just playing around
Prince family ALL DAY EVERYDAY ‼‼‼‼
I hate pickles toooooooo 🤢🤮
Damien:we men we ain't scared of nothing 3 seconds later.... no I can't do it anymore no no no hell no
It's his first times he not that good
Team Damian
I love your guys USsel channel 🤷🏿♂🤰🏼
Oreo or pop tart challenge
Good idea
Good idea
I feel bad for Damien because I have a Amazon tablet and this junk be aggy and glitching
I love you,r Facebook
Good job B 💖💖💖
Move like a snake B
You betta shut up some don't even get crismass
I love you videos they are really funny you guys are super funny and I love to watch them I hope you read this. 😁
i thought damien was bald when he had the hood on🌚😂
Giveaway all the thing that u don't want
I use my phones
Where our part 2


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**Listening Steps (Effective Listening (Read Ahead, Prepare to listen…
**Listening Steps
Effective Listening
Read Ahead
Prepare to listen before class
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Active Listening
Be involved
Critical thinking
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What's the speakers Purpose?
Is the speaker credible?
What do I already know about the topic?
Is the speaker using facts or opinions?
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Note taking
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Taking notes
Leave plenty of room for additional notes
Review notes soon as possible
Listen for the main ideas
Effective Note Taking
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Match Notes With Learning Preferences
Review Notes
Rewrite Notes
Discover your own way to take notes


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In fact, Aquarius likes keeping things casual because to her, having a friend with benefits or a Netflix and chill buddy is just the next best thing to having a serious relationship.


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Read also: recent reviews, test drives, automotive trends and the latest news from the world of cars.
Scion Tuner Challenge 2011: Visiting the Auto Show at Georgian College - Three teams and three cars selected Scion enthusiasts can follow the progress of each team and participate in a competition to win a stay at SEMA Las Vegas by visiting www.tunerchallenge.ca To launch the first "Tuner Challenge" Canada at the beginning of this year, Scion announced a competition inviting all lovers of
For the first time in its existence, the prestigious British brand Rolls Royce will present three models at Auto Show in Quebec: - Rolls Royce Ghost - Rolls Royce Ghost EWB - Rolls Royce Phantom Drophead Coupe Three majestic prestige cars that will attract the attention of visitors.
Upon introduction in 2007 of the Golf and Jetta models by Volkswagen, the manufacturer had stated that the mandate of these two models would be spread over a period of three years. With 2010 fast approaching, so there was reason to believe we would not see these models renewed for a fourth year. However, the manufacturer who wishes to replace these models by eventual Polo would be meeting at
Quite recently, German Chancellor Angela Merkel and the big boss of the German giant Volkswagen, Martin Winterkorn, inaugurated an ambitious program called "National Platform for Electric Mobility", which aims to encourage local manufacturers to design vehicles a fully electric propulsion. Although this incentive has not been accompanied by new grants from the government, it recalls that an
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Monogenic forms of vasculitis are rare but increasingly recognized. Furthermore, genetic immunodeficiency is increasingly associated with inflammatory immune dysregulatory features, including vasculitis. This case report describes a child of non-consanguineous parents who presented with chronic digital vasculitis early in life, is of short stature, has facial dysmorphia, immunodeficiency (low serum IgA, high serum IgM), recurrent bacterial infections, lymphoproliferation, absence of detectable serum C1q, and low classical complement pathway activity. We identified a previously reported de novo heterozygous pathogenic splice mutation in PIK3R1 (c.1425 + 1G > A), resulting in the skipping of exon 11 of the p85α subunit of phosphatidylinositol 3-kinase and causing activated PI3Kδ syndrome type II (APDS2). This explained the phenotype, with the exception of digital vasculitis and C1q deficiency, which have never been described in association with APDS2. No mutations were identified in C1QA, B, or C, their promoter regions, or in any other complement component. Functional studies indicated normal monocytic C1q production and release, suggesting that the observed C1q deficiency was caused by peripheral consumption of C1q. Since C1q deficiency has never been associated with APDS2, we assessed C1q levels in two unrelated patients with genetically confirmed APDS2 and confirmed C1q deficiency in those two cases as well. This observation suggests C1q deficiency to be an inherent but previously unrecognized feature of APDS2. We speculate that the consumption of C1q is driven by increased apoptotic bodies derived from immune cellular senescence, combined with elevated IgM production (both inherent features of APDS2). Secondary C1q deficiency in APDS2 may further contribute to immunodeficiency and could also be associated with inflammatory immune dysregulatory phenotypes, such as the digital vasculitis observed in our case.
Background: Chronic granulomatous disease (CGD) is caused by a malfunctioning nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex in phagocytes, leading to impaired bacterial and fungal killing and hyperinflammation. Objective: To characterize macrophage subsets and cytokine/chemokine signaling loops involved in CGD tissue hyperinflammation. Methods: Cytokine/chemokine production and surface marker expression were analyzed in inflamed tissue of four CGD patients and compared to cytokine/chemokine released by CGD macrophages upon priming to different macrophage subpopulations. Furthermore, the re-priming capacity of CGD pro-inflammatory M1 to M2a anti-inflammatory macrophages was evaluated. Results: In human CGD inflammatory tissue, IL-18 and IFN-γ were detected in significant quantity. Immunofluorescence analysis identified macrophages as one source of IL-18 in inflamed tissue. In vitro, CGD macrophages could be primed and re-primed into all inflammatory/anti-inflammatory macrophage subpopulations. IL-18 was also released by M1 CGD and control macrophages. Conclusion: CGD pro-inflammatory M1 macrophages remain M1 primed in vivo. As CGD M1 macrophages can be re-primed to anti-inflammatory M2a phenotype in vitro, macrophages are kept in M1 state in vivo by a persistent pro-inflammatory environment. Our results suggest a paracrine signaling loop between M1 macrophage derived IL-18 and non-macrophage derived IFN-γ maintaining macrophage pro-inflammatory activity in CGD tissue.
Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs. Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel. Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1-25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0-88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%-subcutaneous; 29%-intravenous; 1%-unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy. Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment.
This study reports a patient with severe skin disease in the context of profound immunodeficiency explained by two concomitant genetic diseases caused by two novel homozygous loss-of-function mutations in PLEC1 and CARMIL2. The work provides additional information on the clinical and immunological manifestations of CARMIL2 deficiency and highlights the particular diagnostic and therapeutic challenge represented by the concomitant presence of two rare monogenic disorders.
Severe combined immunodeficiencies (SCID) comprise a group of genetic diseases characterized by abrogated development of T lymphocytes. In some case reports of atypical SCID patients elevated proportions of γδ T lymphocytes have been reported. However, it is unknown whether these γδ T cells modulate or reflect the patient's clinical phenotype. We investigated the frequency of elevated γδ T cell proportions and associations with clinical disease manifestations in a cohort of 76 atypical SCID patients. Increased proportions of γδ T lymphocytes were present in approximately 60% of these patients. Furthermore, we identified positive correlations between elevated proportions of γδ T cells and the occurrence of CMV infections and autoimmune cytopenias. We discuss that CMV infections might trigger an expansion of γδ T lymphocytes, which could drive the development of autoimmune cytopenias. We advocate that atypical SCID patients should be screened for elevated proportions of γδ T lymphocytes, CMV infection and autoimmune cytopenias.
Immune cell profiles provide valuable diagnostic information for hematologic and immunologic diseases. Although it is the most widely applied analytical approach, flow cytometry is limited to liquid blood. Moreover, either analysis must be performed with fresh samples or cell integrity needs to be guaranteed during storage and transport. We developed epigenetic real-time quantitative polymerase chain reaction (qPCR) assays for analysis of human leukocyte subpopulations. After method establishment, whole blood from 25 healthy donors and 97 HIV+ patients as well as dried spots from 250 healthy newborns and 24 newborns with primary immunodeficiencies were analyzed. Concordance between flow cytometric and epigenetic data for neutrophils and B, natural killer, CD3+ T, CD8+ T, CD4+ T, and FOXP3+ regulatory T cells was evaluated, demonstrating substantial equivalence between epigenetic qPCR analysis and flow cytometry. Epigenetic qPCR achieves both relative and absolute quantifications. Applied to dried blood spots, epigenetic immune cell quantification was shown to identify newborns suffering from various primary immunodeficiencies. Using epigenetic qPCR not only provides a precise means for immune cell counting in fresh-frozen blood but also extends applicability to dried blood spots. This method could expand the ability for screening immune defects and facilitates diagnostics of unobservantly collected samples, for example, in underdeveloped areas, where logistics are major barriers to screening.
Premature T-cell immunosenescence with CD57+ CD8+ T-cell accumulation has been linked to immunodeficiency and autoimmunity in primary immunodeficiencies including activated PI3 kinase delta syndrome (APDS). To address whether CD57 marks the typical senescent T-cell population seen in adult individuals or identifies a distinct population in APDS, we compared CD57+ CD8+ T cells from mostly pediatric APDS patients to those of healthy adults with similarly prominent senescent T cells. CD57+ CD8+ T cells from APDS patients were less differentiated with more CD27+ CD28+ effector memory T cells showing increased PD1 and Eomesodermin expression. In addition, transition of naïve to CD57+ CD8+ T cells was not associated with the characteristic telomere shortening. Nevertheless, they showed the increased interferon-gamma secretion, enhanced degranulation and reduced in vitro proliferation typical of senescent CD57+ CD8+ T cells. Thus, hyperactive PI3 kinase signaling favors premature accumulation of a CD57+ CD8+ T-cell population, which shows most functional features of typical senescent T cells, but is different in terms of differentiation and relative telomere shortening. Initial observations indicate that this specific differentiation state may offer the opportunity to revert premature T-cell immunosenescence and its potential contribution to inflammation and immunodeficiency in APDS.
Ubiquitously expressed Cbl-interacting protein of 85 kD (CIN85) is a multifunctional adapter molecule supposed to regulate numerous cellular processes that are critical for housekeeping as well as cell type-specific functions. However, limited information exists about the in vivo roles of CIN85, because only conditional mouse mutants with cell type-specific ablation of distinct CIN85 isoforms in brain and B lymphocytes have been generated so far. No information is available about the roles of CIN85 in humans. Here, we report on primary antibody deficiency in patients harboring a germline deletion within the CIN85 gene on the X chromosome. In the absence of CIN85, all immune cell compartments developed normally, but B lymphocytes showed intrinsic defects in distinct effector pathways of the B cell antigen receptor, most notably NF-κB activation and up-regulation of CD86 expression on the cell surface. These results reveal nonredundant functions of CIN85 for humoral immune responses.
BACKGROUND: Store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ channels is an essential signaling pathway in many cell types. Ca2+ release-activated Ca2+ channels are formed by ORAI1, ORAI2, and ORAI3 proteins and activated by stromal interaction molecule (STIM) 1 and STIM2. Mutations in the ORAI1 and STIM1 genes that abolish SOCE cause a combined immunodeficiency (CID) syndrome that is accompanied by autoimmunity and nonimmunologic symptoms. OBJECTIVE: We performed molecular and immunologic analysis of patients with CID, anhidrosis, and ectodermal dysplasia of unknown etiology. METHODS: We performed DNA sequencing of the ORAI1 gene, modeling of mutations on ORAI1 crystal structure, analysis of ORAI1 mRNA and protein expression, SOCE measurements, immunologic analysis of peripheral blood lymphocyte populations by using flow cytometry, and histologic and ultrastructural analysis of patient tissues. RESULTS: We identified 3 novel autosomal recessive mutations in ORAI1 in unrelated kindreds with CID, autoimmunity, ectodermal dysplasia with anhidrosis, and muscular dysplasia. The patients were homozygous for p.V181SfsX8, p.L194P, and p.G98R mutations in the ORAI1 gene that suppressed ORAI1 protein expression and SOCE in the patients' lymphocytes and fibroblasts. In addition to impaired T-cell cytokine production, ORAI1 mutations were associated with strongly reduced numbers of invariant natural killer T and regulatory T (Treg) cells and altered composition of γδ T-cell and natural killer cell subsets. CONCLUSION: ORAI1 null mutations are associated with reduced numbers of invariant natural killer T and Treg cells that likely contribute to the patients' immunodeficiency and autoimmunity. ORAI1-deficient patients have dental enamel defects and anhidrosis, representing a new form of anhidrotic ectodermal dysplasia with immunodeficiency that is distinct from previously reported patients with anhidrotic ectodermal dysplasia with immunodeficiency caused by mutations in the nuclear factor κB signaling pathway (IKBKG and NFKBIA).
BACKGROUND: Immunodysregulation polyendocrinopathy enteropathy x-linked (IPEX) syndrome is a monogenic autoimmune disease caused by FOXP3 mutations. Because it is a rare disease, the natural history and response to treatments, including allogeneic hematopoietic stem cell transplantation (HSCT) and immunosuppression (IS), have not been thoroughly examined. OBJECTIVE: This analysis sought to evaluate disease onset, progression, and long-term outcome of the 2 main treatments in long-term IPEX survivors. METHODS: Clinical histories of 96 patients with a genetically proven IPEX syndrome were collected from 38 institutions worldwide and retrospectively analyzed. To investigate possible factors suitable to predict the outcome, an organ involvement (OI) scoring system was developed. RESULTS: We confirm neonatal onset with enteropathy, type 1 diabetes, and eczema. In addition, we found less common manifestations in delayed onset patients or during disease evolution. There is no correlation between the site of mutation and the disease course or outcome, and the same genotype can present with variable phenotypes. HSCT patients (n = 58) had a median follow-up of 2.7 years (range, 1 week-15 years). Patients receiving chronic IS (n = 34) had a median follow-up of 4 years (range, 2 months-25 years). The overall survival after HSCT was 73.2% (95% CI, 59.4-83.0) and after IS was 65.1% (95% CI, 62.8-95.8). The pretreatment OI score was the only significant predictor of overall survival after transplant (P = .035) but not under IS. CONCLUSIONS: Patients receiving chronic IS were hampered by disease recurrence or complications, impacting long-term disease-free survival. When performed in patients with a low OI score, HSCT resulted in disease resolution with better quality of life, independent of age, donor source, or conditioning regimen.
In patients with dysfunctions of the Ca2+ channel ORAI1, stromal interaction molecule 1 (STIM1) or integrin-regulating kindlin-3 (FERMT3), severe immunodeficiency is frequently linked to abnormal platelet activity. In this paper, we studied platelet responsiveness by multiparameter assessment of whole blood thrombus formation under high-shear flow conditions in 9 patients, including relatives, with confirmed rare genetic mutations of ORAI1, STIM1 or FERMT3. In platelets isolated from 5 out of 6 patients with ORAI1 or STIM1 mutations, store-operated Ca2+ entry (SOCE) was either completely or partially defective compared to control platelets. Parameters of platelet adhesion and aggregation on collagen microspots were impaired for 4 out of 6 patients, in part related to a low platelet count. For 4 patients, platelet adhesion/aggregation and procoagulant activity on von Willebrand Factor (VWF)/rhodocytin and VWF/fibrinogen microspots were impaired independently of platelet count, and were partly correlated with SOCE deficiency. Measurement of thrombus formation at low shear rate confirmed a greater impairment of platelet functionality in the ORAI1 patients than in the STIM1 patient. For 3 patients/relatives with a FERMT3 mutation, all parameters of thrombus formation were strongly reduced regardless of the microspot. Bone marrow transplantation, required by 2 patients, resulted in overall improvement of platelet function. We concluded that multiparameter assessment of whole blood thrombus formation in a surface-dependent way can detect: i) additive effects of low platelet count and impaired platelet functionality; ii) aberrant ORAI1-mediated Ca2+ entry; iii) differences in platelet activation between patients carrying the same ORAI1 mutation; iv) severe platelet function impairment linked to a FERMT3 mutation and bleeding history.
[This corrects the article on p. 449 in vol. 8, PMID: 28507545.].
We report our experience in using flow cytometry-based immunological screening prospectively as a decision tool for the use of genetic studies in the diagnostic approach to patients with hemophagocytic lymphohistiocytosis (HLH). We restricted genetic analysis largely to patients with abnormal immunological screening, but included whole exome sequencing (WES) for those with normal findings upon Sanger sequencing. Among 290 children with suspected HLH analyzed between 2010 and 2014 (including 17 affected, but asymptomatic siblings), 87/162 patients with "full" HLH and 79/111 patients with "incomplete/atypical" HLH had normal immunological screening results. In 10 patients, degranulation could not be tested. Among the 166 patients with normal screening, genetic analysis was not performed in 107 (all with uneventful follow-up), while 154 single gene tests by Sanger sequencing in the remaining 59 patients only identified a single atypical CHS patient. Flow cytometry correctly predicted all 29 patients with FHL-2, XLP1 or 2. Among 85 patients with defective NK degranulation (including 13 asymptomatic siblings), 70 were Sanger sequenced resulting in a genetic diagnosis in 55 (79%). Eight patients underwent WES, revealing mutations in two known and one unknown cytotoxicity genes and one metabolic disease. FHL3 was the most frequent genetic diagnosis. Immunological screening provided an excellent decision tool for the need and depth of genetic analysis of HLH patients and provided functionally relevant information for rapid patient classification, contributing to a significant reduction in the time from diagnosis to transplantation in recent years.
AssuntosPeptídeos e Proteínas de Sinalização Intracelular/genética , Células Matadoras Naturais/imunologia , Proteínas com Domínio LIM/genética , Proteínas com Homeodomínio LIM/genética , Linfo-Histiocitose Hemofagocítica/diagnóstico , Proteínas Musculares/genética , Fatores de Transcrição/genética , Doenças Assintomáticas , Degranulação Celular , Criança , Citometria de Fluxo , Testes Genéticos , Humanos , Peptídeos e Proteínas de Sinalização Intracelular/metabolismo , Proteínas com Domínio LIM/metabolismo , Proteínas com Homeodomínio LIM/metabolismo , Linfo-Histiocitose Hemofagocítica/genética , Linfo-Histiocitose Hemofagocítica/imunologia , Proteínas Musculares/metabolismo , Mutação/genética , Transplante de Órgãos , Guias de Prática Clínica como Assunto , Prognóstico , Estudos Prospectivos , Irmãos , Fatores de Transcrição/metabolismo , Sequenciamento Completo do Exoma
BACKGROUND: In contrast to adult-onset inflammatory bowel disease (IBD), where many genetic loci have been shown to be involved in complex disease etiology, early-onset IBD (eoIBD) and associated syndromes can sometimes present as monogenic conditions. As a result, the clinical phenotype and ideal disease management in these patients often differ from those in adult-onset IBD. However, due to high costs and the complexity of data analysis, high-throughput screening for genetic causes has not yet become a standard part of the diagnostic work-up of eoIBD patients. METHODS: We selected 28 genes of interest associated with monogenic IBD and performed targeted panel sequencing in 71 patients diagnosed with eoIBD or early-onset chronic diarrhea to detect causative variants. We compared these results to whole-exome sequencing (WES) data available for 25 of these patients. RESULTS: Target coverage was significantly higher in the targeted gene panel approach compared with WES, whereas the cost of the panel was considerably lower (approximately 25% of WES). Disease-causing variants affecting protein function were identified in 5 patients (7%), located in genes of the IL10 signaling pathway (3), WAS (1), and DKC1 (1). The functional effects of 8 candidate variants in 5 additional patients (7%) are under further investigation. WES did not identify additional causative mutations in 25 patients. CONCLUSIONS: Targeted gene panel sequencing is a fast and effective screening method for monogenic causes of eoIBD that should be routinely established in national referral centers.
AssuntosDiarreia/etiologia , Predisposição Genética para Doença , Doenças Inflamatórias Intestinais/genética , Idade de Início , Criança , Pré-Escolar , Doença Crônica , Feminino , Estudo de Associação Genômica Ampla , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Lactente , Recém-Nascido , Masculino , Mutação , Sequenciamento Completo do Exoma
Lipopolysaccharide-responsive beige-like anchor protein (LRBA) belongs to the enigmatic class of BEACH domain-containing proteins, which have been attributed various cellular functions, typically involving intracellular protein and membrane transport processes. Here, we show that LRBA deficiency in mice leads to progressive sensorineural hearing loss. In LRBA knockout mice, inner and outer hair cell stereociliary bundles initially develop normally, but then partially degenerate during the second postnatal week. LRBA deficiency is associated with a reduced abundance of radixin and Nherf2, two adaptor proteins, which are important for the mechanical stability of the basal taper region of stereocilia. Our data suggest that due to the loss of structural integrity of the central parts of the hair bundle, the hair cell receptor potential is reduced, resulting in a loss of cochlear sensitivity and functional loss of the fraction of spiral ganglion neurons with low spontaneous firing rates. Clinical data obtained from two human patients with protein-truncating nonsense or frameshift mutations suggest that LRBA deficiency may likewise cause syndromic sensorineural hearing impairment in humans, albeit less severe than in our mouse model.


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November 29, 2017. Papa's living room in Greenville, SC. We talk about childhood, my grandmother, and regrets.
I interviewed my mom about her life.
Emma Bao (13) interviews her father, Yingbin (46) in Greenville, SC. At first they talk about immigration and what it was like to be new to such a huge country. Then, they talk about school and how it was one...
Andy talks about how he learned to play, what significance it has for him, and why he wants to share his knowledge.
On December 6, 2018, Hannah Brewer and Susan Brewer had a very good conversation. Hannah learned more about her mom and her mom's job. She learned that life as a new photographer wasn't always easy but Susan definitely enjoys her...
Since I visited friends instead of family this Thanksgiving, I decided to interview my 15-year-old sister, Sydney, at our house. Before I got into the main questions, I had her tell the listners a little bit about herself. Then, I...
In this interview, conducted December 2018 in Greenville, South Carolina, Richard Collot (54) and Nathan Collot (14) talk about his life before Nathan was born. He is interviewed about what he did as a teenager. He also talks about life...
This is the interview of some of the major events that happen in Clint Davis's life.
Interview with my mom
An interview with Monique on how her mother has impacted her life for U101 project at University of South Carolina.
In this interview, conducted in November 2017 in Simpsonville, South Carolina, Emily Yi interviews her father, Bing Yi, about his childhood in the Chinese city of Dalian. Dr. Yi talks about his parents, extended family, and the people who have...
This is a brief history of how my grandmother went from small town West Virginia to Rochester, New York.
This is an interview with Barrie Bradley about her life. She tells stories of her childhood and hardships and how she got past them. Barrie is truely a warm-hearted loving grandmother (as she said she wants to be remembered by).
We talked about her life experience especially as an immigrant.
Linnea Guy (13), from Greenville, South Carolina and Miriam Wood (69), also from Greenville but originally from Caracas, Venezuela, discuss early experiences from Miriam's first months spent in America. In this interview, conducted in Greenville, South Carolina on November 28,...
I ask my mom what coming to America from Egypt was like.
In this interview, conducted in 2017 in Greenville, SC, Mitchell Esbenshade interviews Andris Bibelneiks about his experiences growing up. Mr. Bibelneiks shares what it was like being forced to move out of Latvia, and to Germany. He also talks about...
CeCe Henry asks Betsy Henry what it was like to grow up in Texas, and how she dealt with change throughout her life.
A conversation about music.
Garner Hart (14) interviews his father, Daniel Hart (41) about his childhood experiences. These experiences included family vacations and stories about his grandparents. The interview starts with school but then goes to summers. Afterward, the two talk about Daniel's parents...
Hettie Brazier interviews her mom, Diane Brazier, on December 5, 2018. They talk about the influences in her mom's life along with Diane's favorite memories from childhood.
Granddaddy told stories of his childhood and some of his children. Hank occasionally interjected his perception. Ken shared stories of his childhood friends and what he learned.
This interview with my mom details what she wants me to be in life and other things.


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I recall a third-generation Japanese at U. How will this same person want to define himself if we meet him in the same place 20 years hence?
He sees himself as both Lebanese and French. But when I take the same two elements together, I find myself face to face with my own specificity. If he was stopped and questioned HOW, he would say first of all that he was a Bosnian, then that he was a Muslim.
For that is a country where you are c onstandy having to question yourself about your affiliations, your origins, your relationships with oth e r s and your possible place in the sun or in the shade.
It's the recollection of certain books I 've read and films I've seen that leads me to choose this example. I feel like screaming aloud: In other words, ideas that have hitherto prevailed throughout history are not necessarily those that ought to prevail in times to come.
Major themes[ edit ] This novel explores confrontations between Islam and Christianity as well as the mutual influence that the two religions had on each other and on the people they governed. My aim is quite different, and I want to make it plain: Not only by fanatics and xenophobes of all sides, but by you and me, each one of us.
O n the contrary, it stands for all that has been built up over the centuries: Why so many manifestations of conservatism and violence?
One could find dozens of other examples to show how complex is the mechanism of identity: The situation is even more delicate on the other side of the Rhine. Violence and the Need to Belong, lives in France. What it is that makes each one of us unique and dissimilar to any other individual has been one of the fundamental questions of philosophy from Socrates to Freud.
Its history must be respected. Off-slope, there are many opportunities for cross-country skiingsnowshoeingand snowmobiling. If I travel to a foreign country, within seconds my identity changes to a more national one.
A few bad experiences in the years before I met her led her to embrace more firmly her identity as Japanese. Let us observe a man of about 50 whom we see in the street.
This is an essential point with regard to current concepts of identity. In the many countries where a native population with t i s own local culture lives side by side with another, more recendy arrived p opulation, with different traditions, tensions arise that not only influence the behaviour of individuals but also affect the atmosphere prevailing in society as a whole and have an impact on political debate.
There will always be different and even contradictory interpretations, however much people study the scriptures, consult the commentators or set out the various arguments. Or, more prosaically, like clauses in a contract.
Or a Yugoslavian through and through. How did you respond? Equestrian sports - Equestrian sports are increasing in popularity, especially in the highlands of Lebanon, where the game of polo is played in farming villages and towns around the country.Amin Maalouf is a well known novelist and winner of France's most prestigious literary award, the Goncourt Prize.
He grew up in Lebanon and moved to France inat the age of I want to try and understand why so many people commit crimes in the name of identity," writes Amin Maalouf. Identity is the crucible out of which we come: our background, our race, our gender, our tribal affiliations, our religion (or lack thereof), all go into making up who we are.3/5(1).
by Amin Maalouf. The notion of identity - personal, religious, ethnic or national - is one that has given rise to heated passions and crimes throughout the history of mankind. Founded in by childhood friends in Cairo, Egypt, Cairokee is the first authentic Egyptian rock band.
Today, they are considered one of the most famous Egyptian bands in the Middle East. Leo Africanus is a novel written in French by Amin Maalouf, depicting the life of a historical Renaissance-era traveler, Leo palmolive2day.com very little is actually known about his life, the book fills in the historical episodes, placing Leo in the company of many of the key historical figures of his time, including three popes, (Leo X, Adrian VI, and Pope Clement VII), two Ottoman.
The Genes of the Soul: Amin Maalouf on Belonging, Conflict, and How We Inhabit Our Identity "A person's identity is like a pattern drawn on a tightly stretched parchment.
Touch just one part of it, just one allegiance, and the whole person will react, the whole drum will sound.".Download


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2nd part of the lecture. This lecture will discuss how understanding and applying simple neuroanatomical rules, one can localize the damage along the neuroaxis, the first crucial step toward making the correct clinical diagnosis and initiating treatment.
This lecture focuses on how the immune system can target and attack the nervous system to produce autoimmune responses that may result in diseases such as multiple sclerosis, neuromyelitis and lupus cerebritis manifested by motor, sensory, and cognitive impairments. Despite the fact that the brain is an immune-privileged site, autoreactive lymphocytes producing proinflammatory cytokines can cause active brain inflammation, leading to myelin and axonal loss.
Most psychiatric disorders (most notably dependence syndromes, depression, psychosis, and autism) are characterized by impaired social interaction, with many patients preferring a drug of abuse. This lecture focuses on the latest research on the neural basis of normal and impaired social interaction.
This lecture will provide an overview of neuroimaging techniques and their clinical applications.
This lecture will provide an overview of neuroimaging techniques and their clinical applications
This lecture will highlight our current understanding and recent developments in the field of neurodegenerative disease research, as well as the future of diagnostics and treatment of neurodegenerative diseases
This lecture provides an overview of depression (epidemiology and course of the disorder), clinical presentation, somatic co-morbidity, and treatment options.
How genetics can contribute to our understanding of psychiatric phenotypes.
The lecture focuses on rationale for employing neuroimaging methods for movement disorders
An overview of some of the essential concepts in neuropharmacology (e.g. receptor binding, agonism, antagonism), an introduction to pharmacodynamics and pharmacokinetics, and an overview of the drug discovery process relative to diseases of the Central Nervous System.
How does the brain learn? This lecture discusses the roles of development and adult plasticity in shaping functional connectivity.
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Justin Bieber gushed over his wife, Hailey, in the most adorable way just weeks before their one-year wedding anniversary.
The "I Don't Care" singer shared several solo pictures of his model babe and sung her praises on Instagram Thursday.
Posting a combination of her model shots and relaxed private life at home, the Grammy winning artist wrote a tear-jerking tribute for Wifey Appreciation Day.
"I fall more in love with you every single day," he wrote.
Bieber added that Hailey is "the greatest thing that has ever happened to me" and spoke from the heart, writing, "I would be lost with out you."
His wife sweetly responded, "best friend."
Mr. and Mrs. Bieber will celebrate their one-year wedding anniversary next month after secretly tying the knot at a New York courthouse in September 2018.
Despite claiming they wanted to have a big celebration, there has been no date set as of yet.
Their first year of marriage has been a turbulent year for Bieber.
As The Blast reported, the 25-year-old sought treatment for depression just months after he wed the model.
Luckily, his new bride stuck by his side and appeared to be very supportive while he was seeking help.
Hailey didn't waste anytime cashing in on her new famous last name.
According to documents, obtained by The Blast, Hailey filed to register "Hailey Bieber" on October 10, 2018 for the purposes of a clothing line.
She also locked up her maiden name, "Hailey Baldwin," as well as a name called "HRB3."
The docs marked the first time Hailey publicaly acknowledged her marriage with JB.


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Thousands of rock-throwing demonstrators battled riot police in Gdansk today, and an estimated 15,000 Solidarity supporters staged a two-hour peaceful May Day march in Warsaw to protest food price hikes and political arrests.
About 500 Solidarity activists chanting "Solidarity!" and "Lech Walesa!" forced their way into the official government May Day parade in Gdansk. They interrupted the parade for 10 minutes by sitting down in the road before being routed by baton-wielding police units.
About a mile from the parade route, 3,000 mostly young demonstrators gathered near the former Solidarity headquarters and hurled stones ripped from the streets at a column of helmeted riot police, Western reporters said.
Several People Injured
The police initially showed restraint but then charged with batons and shields and used water cannon and tear gas to disperse the crowd. Several demonstrators and police were injured.
One member of the riot police was beaten to the ground by demonstrators and taken away in an ambulance. A protester who apparently threw a rock at a police vehicle was rammed by a police car and then beaten by riot squads. The protester also was taken away by ambulance.
Scores of demonstrators were arrested in the clash, which lasted more than an hour and left the street littered with stones and debris.
Solidarity leader Walesa attempted to join the government parade in Gdansk but returned home when his way was blocked by hundreds of riot police. "We have no intention of getting into fights," he said. "It's a shame that someone divides us so brutally."
Slogans and Banners
In Warsaw, an estimated 15,000 people chanting Solidarity slogans and carrying Solidarity banners marched past cordons of riot police in a two-hour demonstration before dispersing.
Two senior Warsaw Solidarity activists, Jacek Kuron and Seweryn Jaworski, were detained by police in connection with the "illegal" parade, government spokesman Jerzy Urban said.
Large concentrations of riot police were stationed in other major Polish cities, including Wroclaw, Krakow, and Czestochowa but there were no reports of clashes.
But in the western city of Poznan, riot police used batons to disperse a crowd of about 2,000 demonstrators who tried to march from a Roman Catholic Mass to a monument to workers killed in 1956 anti-government riots, Solidarity sources said.


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The director general of the Bahamas Ministry of Tourism and Aviation, Joy Jibrilu, details the damage left in the aftermath from Hurricane Dorian and what the Bahamas will need to move forward.
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Inspired by a historic festival photograph the Artistic Director Carlo Chatrian ponders on the image of Italian actress Monica Vitti.
Medienboard, the Nipkow Programm and the Berlinale have formed a cooperation to pool their know-how and networks in the field of film scholarships.
"We're very pleased that Samuel Finzi will be hosting the inauguration of the 70th Berlinale. His eloquence, energy and improvisation skills promise an entertaining start to the festival," say Mariette Rissenbeek and Carlo Chatrian.
The Berlinale Event Ticket of the Deutsche Bahn.
The Retrospective of the 70th Berlin International Film Festival will be dedicated to the American film director, producer, and screenwriter King Vidor (1894-1982).