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2005 Pipeline Report—Part I: Complications
The title not only refers to the multi-side effects that people are dealing with on a regular basis both with and without their meds, but also to the myriad possibilities of what you can take (not counting the drugs out of general use now, nor the two-in-one or the three-in-one formulations, there are 17 drugs to mix and match), what you can't take it with (due to interactions, either within the ARVs themselves or when you are taking non-ARV meds, be they lipid lowerers, antidepressants, OI prophylaxis, or because of access issues), what you try to avoid (due to side effects, previous treatment history), and general treatment fatigue (we are in the ninth year of generalized HAART).
At the 2005 CROI, the 12th Conference on Retroviruses and Opportunistic Infections, we were treated to 774 posters. 92 of these were posters specifically on side effects, ranging from fat redistribution to hepatitis flare-ups. In nearly 100 others, regarding the efficacy of drugs or studies, side effects reporting plays an important (though understated) role. (I am leaving out resistance and its effects.) There were also 182 talks given. Of these, 14 were on adverse events, which maybe underestimates their importance, because all of these 14 talks were given in the largest (2000+ seats) Auditorium in the conference center. At least half of these are webcast, and can be found at www.retroconference.org/2005/Pages/webcasts.htm along with others like "Can we find better PIs?" "Better" in large part meaning less adverse events. I am not counting other talks, like Controversies, or Challenges, or Responses, also in the Auditorium, which in no small part touched on "complications." Finally, in the pre-conference Workshop for New Investigators, a large chunk of the day (up to 40%) was dedicated to "management issues."
Just say no
Over the past two years, in TAG's—and ATAC's—New Drug Approval Position Papers, many AE issues have been highlighted. A number of these specific issues were revisited in "tolerance" posters at CROI. All posters/abstracts below can be found through www.retroconference.org/Search_Abstract_2005 putting the poster/abstract number in the search box.
Abacavir (ABC)
FDA presented a poster on the "Increased rate and severity of the hypersensitivity reaction (HSR) to ABC, in randomized controlled clinical trials", especially QD vs BID (abstr 835). An increase was seen simply by crunching numbers—there is more HSR and more severe HSR today than when ABC was first approved. That could be a more stringent vigilance by doctors and patients (chapeau!), but incidence has gone up, be it ABC alone (Ziagen®), in the combo pill with 3TC (Epzicom®), and in the once daily (QD) vs twice daily (BID) administrations. FDA has changed the label and has called for more studies to address this. In poster 836, GSK, with the same data, said HSR is not on the increase, even with the earlier 4.6% measurement increased clearly to 9.6% in the poster (abstr 836). Go figure. They did a wider analysis and saw that African-Americans and males separately had a higher probability of getting HSR, as do people with low CD4.
Tenofovir (TDF)
Does tenofovir accelerating bone loss (abstr 825)? Add TDF to duration of HIV infection and elevated bilirubin (ATV?), and there is "more bone loss." Poster 824 links serum cholesterol concentrations and fasting glycaemia to decreased BMD. Poster 827 talks about Macro CK-2 being an indicator of cellular necrosis and cytotoxicity, and that there are high levels of creatine kinase type 2 (CK-2) in people taking TDF. Poster 823 shows that although there is not much difference between d4T and TDF in bone loss, 75% of people with osteopenia at baseline continue with it at 3 years, while 10% progress to osteoporosis. And most of those with osteoporosis continue having it at 3 years. 10% of those with normal BMD at baseline progress to osteopenia. Posters 818-820 showed an association between tenofovir and low glomular filtration rates (renal dysfunction) and creatinine clearance.
A poster from Poland (abstr 824) suggested that the rates of osteopenia and osteoporosis, regardless of treatment experience, is high in HIV+ people. Osteopenia was observed in 35% of patients, osteoporosis in 19%, while no bone density alterations were observed in the rest. Serum cholesterol concentration (SCC) is associated with decreased bone mass and high osteoblastic activity in HIV+ patients. A further increase of SCC was observed in patients on HAART with even higher values in patients with lipodystrophy. A positive correlation between serum osteocalcin and total cholesterol, LDL cholesterol, triglycerides, and fasting glucose levels were observed in HAART patients, which were not seen in naïve individuals. The decrease in intravertebral marrow fat was negatively correlated with total cholesterol concentrations in HIV+. An increase in serum osteoprotegerin (a marker for osteoporosis) in HIV+ patients vs control was observed. Hypercholesterolaemia may increase the risk of osteopenia and osteoporosis in this population.
Enfuvirtide (T20)
Posters 837 and 838 were by FDA and David Cooper. FDA said that almost all subjects experience a severe grade ISRs which warrants further investigation into improving ISRs (86%). Cooper says that the more peripheral fat you have, the easier time you'll have of it (duh?).
Atazanavir (ATV)
Poster 842, ATV/r decreases lipid accumulation. Plasma lipids also went down in abstr 850. Abstr 858 said it again: lipid profiles improved after 12 weeks on ATV (this time, without /r). Abstr 745 looked at bilirubin as an indicator of adherence. Not perfect.
Other complications
It was shown by various groups that switching from AZT or d4T (thymidine analogs, seen to have negative mtDNA effects) to ABC or TDF switches loss in limb fat to a slight gain. This gain, after 1 year, is approximately 0.5 kilo which is not clinically significant. Of course, the loss has been stopped, and maybe a reversion has started, but it has probably taken a number of years to have lost this amount of fat (through mt depletion and other unspecified mechanisms), and this one year data is a good sign, but the mt effects have not been measured, and the increase in limb fat is not necessarily an "improvement", as Cristine Katlama so elegantly reminded us, it is simply an increase, and very modest at that.
Note: mt (mitochondria) are tiny organelles, scores of which are found within nearly every cell of the human body—they play a key role in releasing cellular energy. This energy flow helps them be both self-replicating, oxidize food compounds and produce ATP (adenosine triphosphate), a phosphorylation of oxygen. Some NRTIs, specifically thymidine analogs, cause mitochondria's amino acid(s) to act slightly differently. The affected protein(s) still work, but inefficiently, thus, possibly, many organ-specific pathological changes may be related to the defective mtDNA replication (myopathy, neuropathy, lactic acidosis, congestive heart failure, hepatotoxicity, metabolic abnormalities).
Christine Katlama (France) and Pablo Tebas (Spain) got into a sparring match over whether NRTI-sparing regimens offered an increase or an improvement in peripheral fat. Tebas (abstr 40, reporting for ACTG5125) was gentleman enough to give in, that in fact, the reversal of fat loss in the arms and legs was, at least at one year, an increase that was only the beginning of an improvement. Thanks for coming from Paris to correct the ACTG's English, Christine. Although, the same no-NRTI regimen (Kal+EFV) thno-PI arm.
Although there were many studies that showed that switching from AZT or d4T-based regimens to ABC or TDF based ones improved fat loss (Graeme Moyle with the RAVE study, Rob Murphy with ACTG 5110, Pablo Tebas, MITOX), what was gained probably can't yet be called an improvement. At one year, the peripheral fat loss was stopped and a non-clinically significant increase was measurable. So, the new drugs switched to (whether they are NRTIs, or even an NRTI-sparing regimen (Kal+EFV, Kal+NVP)) helped stop one problem but the significance is not clear (is the mtDNA depletion halted? Is the virological failure larger with no NRTIs?). Moyle figured that the reversal after one year is approximately 12% of what was lost (so, another 6 years on this therapy and your peripheral fat will be returned?) Actually, in these NRTI sparing regimens, although limb fat loss was halted and begun to be turned around, lipid issues (as would be expected with Kaletra) worsened.
In two of the studies looking at sparing the NRTIs to help the lipoatrophy, Moyle (abstr 44LB) and Murphy (abstr 45LB) showed that sparing the NRTI class or at least avoiding thymidine analogs (AZT, d4T) may be helpful strategies. Both of these studies had approximately 100 people with more than 500 CD4s. Murphy's had 600 CD4s. A break from treatment period (even a short one) might have done just as well. Maybe in the next trial, there can be an arm of just that—an arm that continues, an arm that spares NRTIs, an arm that spares AZT/d4T, and an arm that stops (in people who have more than 500 CD4s, for example). Moyle did note that ABC had more discontinuations and side effects than TDF (more than 6% hypersensitivity).
Peter Reiss from Amsterdam talked of Lipodystrophy as if it were a Puzzle, doing an overview (abstr 65 and webcast at www.retroconference.org/2005/Pages/webcasts.htm) that succinctly gets one up-to-date regarding the most important issues—including the mitochondrial effects of many of the NRTIs and laying out the many things that are still not clear about changes in body fat distribution. He mentions that it is not easily reversible, and goes as far as to suggest that even without knowing the precise mechanisms, we have a decent idea of those drugs more associated with it and so maybe more avoidable for a reduced (or at least delayed) incidence.
Kate Mulligan showed mixed patterns of change from ACTG substudy 5005S (abstr 38), which looked at 2 nukes and 1 NNRTI. While about one-third gained fat in both trunk and limbs, another third lost fat in both areas. What we consider the "typical" gain of fat in the trunk and loss in the limbs was seen only in about a quarter of patients. She published just a few weeks earlier (Jan 2005) in AIDS a look at a part of the WIHS cohort, in this substudy, some 271 women. In three groups, HIV-, HIV+ on HAART and HIV+ not on HAART, she saw a significant loss of leg fat in the women on HAART, with a background of generalized obesity in all three arms. There also was a tendency in the HIV+ PI group to retain trunk fat vs the HIV+ no-PI group. She mentions that these women are comparable to the initial report from Australia on lean white men. Also, nadir CD4 count correlates with leg fat in these women. Age >30 is associated with more fat in this study. Exercise warrants further investigation.
A small French study (abstr 39) showed a positive effect on lowering triglycerides of an omega-3 capsule taken TID for 8 weeks.
Rosiglitazone was once considered to be a possible help for lipid problems. It has been shown not to be of help, and one more time by a Toronto study of lipid profiles and insulin resistance (abstr 854) in 96 patients over 24 weeks. Looking at why this might be, various groups from Australia saw that it might have to do with previous thymidine analog use (abstr 41) that shuts down expression of just what the rosiglitazone is active on, PPAR gamma.
How good is good?
A number of studies looked at adverse events in children (abstr 53—56, 99, 410, 978, 760—778) and in women (NVP in women, abstr 784), and many studies looked at them as factors in predispositions, like abstr 42, Effect of sex, age and lipid changes, a DAD analysis presented by Dr Wafaa El-Sadr. Looking to see if the MI effect of HAART continues, she presented an analysis of their 23,441 patients (24% women).
By 2004, the myocardial infarction incidence increased from 1.39/1000 patient-years in those not exposed to HAART, to 2.53/1000 patient-years in those exposed for < 1 year, to 6.07/1000 patient-years in those exposed for = 6 years. After adjustment for other potential risk factors, there was a 1.17-fold increased risk of myocardial infarction per additional year of HAART exposure. While the overall absolute risk of myocardial infarction remains modest, the risk continues to increase with longer exposure to HAART over the first 7 years of use. Although the rate of myocardial infarction was higher in men than women (2.04), the relative risk associated with HAART was similar in men (1.14) and women (1.38). The relationship was similar in younger and older patients (men > 45 and women > 55 years). Including time-updated levels of serum total cholesterol, HDL cholesterol, and triglycerides in the same model reduced the association of an additional year of HAART with myocardial infarction to 1.10. Lipodystrophy was not associated with the risk of myocardial infarction. Dyslipidemia explained part but not all of the association of HAART with risk of myocardial infarction.
Docs from my barrio
I had the luck to interview two clinicians from Barcelona, both of whom focus greatly on adverse events. Ana Milinkovic and Esteban Martinez work as a team in the Hospital Clinico in Barcelona.
Martinez spoke on the relative CV and lipid risks that different HIV drugs might present (abstr 63). Although lipid "derangements" may be related to HIV infection itself, they are far more common and severe in association with HAART, irrespective of the drugs used. PIs/r induce more lipid abnormalities than non-boosted PIs and stavudine has more severe effects than other nucleoside reverse transcriptase inhibitors (NRTIs). Ritonavir has the strongest hyperlipidemic effect among PIs while atazanavir appears to have little if any. One compounding issue is that even with similar HAART, lipid disorders are more common in antiretroviral-experienced patients, with prior history of hyperlipidemia, or with clinically evident body fat changes. Diet has not been consistently related to lipid abnormalities in HIV+ patients, although the nutrition industry may take issue. Physical exercise may improve hypertriglyceridemia, which again in the literature, may be more compelling than the 16-week data that shown to be of limited effect in HIV. Switching from PIs to NNRTIs or abacavir or atazanavir, as well as from stavudine to tenofovir may improve lipid abnormalities, although distinct adverse effects and virological failure may arise. Dosage reductions in boosted PIs or stavudine and therapy interruptions may affect lipid parameters positively but their impact on the control of HIV infection is not clear. Fibrates, low-dose (10 mg) atorvastatin, or both may be used but their lipid-lowering effects are usually lower than in the general population.
It seems reasonable to evaluate lipid disorders in HIV+ patients according to the same criteria used in the general population, in the absence of HIV-specific data. The impact of individual antiretroviral drugs on lipid parameters should be included among the factors to be considered on prescribing HAART.
Although Martinez's major poster was on Spain, the results may be applicable across cultures (abstr 870). To wit, in cardiovascular disease, which the DAD cohort has now given a risk factor of 6.70/1000 pt years to (see above), there are some common factors that may lower the risk, some of which are adjustable, like smoking, obesity (including diabetes and blood pressure as well as waist circumference), cholesterol and triglycerides, which can be worked on to some degree, and some of which are not adjustable: sex, age, family history of disease. Tobacco smoking, and high plasma levels of total cholesterol and triglycerides were identified as the factors more heavily associated with a high cardiovascular risk in HIV+ patients in Spain, all of which can be dealt with, although some things, like changing diet and going to the gym may be more long term than immediate (so start already!). The DAD cohort has not seen that lipid-lowering agents have any demonstrable effect. In a related paper in the NEJM in December 2004, Hu showed that higher weight and less physical activity were both shown to be independent predictors of death (in 100,000 American nurses over 24 years). If you feel well enough, get moving! From the accompanying editorial: be fit and lean if you can be!
Milinkovic spoke of the normalization of killer inhibitory receptors and lectin like receptors, but not natural killer cells, in patients on HAART (abstr 513). Natural killers drop after one year on an immunologically-driven STI, but not in a virally-driven one. CD4 cells are lower after one year of an ID STI than a VD STI or the (on treatment) control. After one year, there was no difference in any of the 3 arms.
Milinkovic also presented a poster on reducing the dose of d4T to 30 mg as the normal maximum dose (abstr 857), and that 40mg is effectively an overdose which may be part of the problem all these years. She compared that to d4T(40) (standard dose) vs TDF. Median CD4s were 612 (again, my quick answer, is get these people off treatment if they are suffering mt issues, etc). One person in the d4T(40) arm got hyperlactataemia. Trigs continued to rise in the d4T(40) group (+19), they fell by 40 in the d4T (30) arm, and fell by 133 in the TDF arm. Total chol went up by 4 with d4T(40), down by 4 with d4T(30) or down by 28 with TDF. Total fat and limb fat followed these indicators, with d4T40 (-597, -247), d4T30 (+332, +77), and TDF (+1005, +440).
Hyperlactatemia (increased plasma lactate) with a normal blood pH is lactic acidemia. Lactic acidosis consists of a high lactate level accompanied by metabolic acidosis. The spectrum of lactic acidemia ranges from fulminant multiorgan dysfunction—severe acidosis and hemodynamic instability, to less severe symptomatic hyperlactatemia with hepatic steatosis (fatty liver), to intermittent or chronic low-grade hyperlactatemia without acidosis, steatosis, or symptoms.
Although most cases of lactic acidemia are asymptomatic, a variety of nonspecific presenting complaints have been described, including nausea, vomiting, and diffuse abdominal pain; fatigue, weakness, weight loss, rapid or difficult respiration on exertion, heartbeat disturbances, and neurologic findings have also been reported in the absence of gastrointestinal complaints. Liver abnormalities, including hepatomegaly (enlargement of the liver), hepatic steatosis, and elevated serum transaminases are common in symptomatic hyperlactatemia and almost ubiquitous in NRTI-induced lactic acidosis. The onset of symptoms is usually not acute, occurring over weeks to months, although acute fulminant cases associated with multiorgan (especially liver) dysfunction occur rarely.
Where do we go from here? As the complications get better and better defined, we want to steer clear of certain drugs, which can't always happen, and certainly not in any speedy fashion. It took a good while to bury ddC (the sponsor just announced its discontinuation in March 2005!), while some 50% of people not in the first world are still taking d4T at full (over-) dose, and need to switch out (but to what, and how?). Treatment Interruptions done in conjunction with your doctor are becoming more appetizing, at least in the short term, for short periods of time, which may help in the complications arena. More generalized healthy attitudes need to be taken up by the ever-greying HIV+ population that is feeling these concerns most. More and better lifestyle studies are needed, specific to the different HIV+ populations.
Metabolic Complications of HIV Therapy, HIV InSite Knowledge Base Chapter, May 2003, D C.Chow, et al, HIVInsite.
Am J Physiol Heart Circ Physiol 284: H1-H9, 2003; Vol. 284, Issue 1, H1-H9, January 2003, Defective mitochondrial DNA replication and NRTIs: pathophysiological implications in AIDS cardiomyopathy, W Lewis, Department of Pathology, Emory University, Atlanta, Georgia.
Although not much was presented on azones and fibrates during CROI, a helpful paper came out right after: Pioglitazone improves HAART-related "metabolic syndrome", while fenofibrate was not shown to be useful. Studies in the past of rosiglitazone in patients on HAART find the drug improves insulin resistance, but increase triglyceride levels.
Among patients on pioglitazone for 12 months, mean insulin resistance index values, quantitative insulin sensitivity check index and fasting insulin levels improved significantly. Pioglitazone increased mean HDL cholesterol levels, and decreased mean triglyceride levels by 27.5%. While the drug tended to increase LDL cholesterol as well, LDL particle size also tended to increase, "which resulted in lower levels of atherogenic LDL cholesterol."
No significant effect of fenofibrate was seen on insulin resistance, lipid levels or blood pressure.
A Harding, Reuters Health, 2 March
A Gavrila, Beth Israel Deaconess Medical Center, et al, 1 Mar 2005, Clin Infect Dis 2005;40:745-749.
Kind thanks to AIDS Action Baltimore for permission to reprint this article.


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Eyes, Ears, & Beyond
To navigate, hunt, and communicate, living things must decode the mysterious world around them. Extraordinary eyes and ears certainly come in handy for finding food and avoiding disaster.
But a few of these creatures collect clues using astonishing equipment that goes far beyond the range of our fives senses to detect forces we can only imagine.
- Pheromones: some animals like the Giant Silkworm Moth use enormous antennae to detect the odor of a potential mate. A male can sniff out a single molecule from a female miles away!
- Electrical Fields: other animals like the Hammerhead Shark use special pores in their snouts to sense the electrical field given off by the heartbeat of their prey.
- Magnetic Fields: the brain tissue of certain animals like sea turtles contains magnetite, which acts as a natural compass and helps the animal to navigate accurately over immense distances.
Some researchers have studied these extra-sensory systems and have learned to replicate them in human devices. For example, the "UltraCane" uses echolocation like a bat to help blind people "see" what's ahead and above, and an echolocating bike currently in development can provide even more independence.

subset: commoncrawl


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The wireless outdoor lighting solution guide includes:
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• Product datasheets: Wireless outdoor lighting solution datasheets


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I fell in love with a guy from Ghana here in the United States he has lived here for seven years..his mother and uncle just informed him that because of his royalty bloodline it is his duty to Marry a Ghanaian girl to preserve their bloodline...is there anyway around this?? Anyway I can win over his uncle, his mother already loves me but is in agreement with her brother!!! Please any information would be greatly appreciated, I'm completely heart broken
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text: I just love searching for old vintage books, but as a military wife, we are always on the move. I have such a hard time finding access to vintage items. So I decided to get creative and make my own. I have so many people ask me how I make them, so I decided It would be easier just to do a DIY tutorial to share.


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- monthly subscription or
- one time payment
- cancelable any time
"Tell the chef, the beer is on me."
"— limpwristpointedfist
fuck your white body positivity. fuck your cis body positivity. fuck your able-bodied positivity. fuck turning the shame on people, not power.
you're doing it wrong if you don't understand the legacies of colonialism and racism in beauty standards, in the states and abroad. if you don't understand their relationships to eating disorders in poc communities. if you don't understand how brown and black people struggle to love their racialized bodies.
you're doing it wrong if you don't understand how trans people, most especially trans womyn, due to the culture of absolute violence that is reserved specifically for them, perpetuated even by other trans people, struggle to love their bodies in this cissexist world (thanks, white gender binary). if you don't understand that sometimes, trans people just hate their bodies because they aren't right at the time, that they will never be able to achieve the bodies that they want. if you don't understand that trans people will always have a complicated relationship with their bodies.
you're doing it wrong if you don't understand that disabled people struggle to love their bodies in this ableist world. if you don't understand that some disabled people view their bodies as being wrong or bad, and are struggling with making peace with that. if you don't understand that disabled people will always have a complicated elationship with their bodies.
you are doing your boring feminism so wrong if you don't understand that you're hurting the most marginalized."
" If you say that transwomen are appropriating femininity, then you're appropriating my oxygen. "— slutmagic
" I am not interested in situating myself personally in this book. There are a variety of reasons to justify my position. First, autobiography is the only discourse in which transsexuals are permitted to speak. An academic text on transsexuality and the institutional world that does not address the transsexual author's personal history, then, is a critical intervention in the existing knowledge paradigm. "— Viviane K. Namaste in: "Invisible Lives: The Erasure of Transsexual and Transgendered People."
"— Dear Cissexism,
My non-binary experiences are valid. My non-binary experiences are defined by me. I do not identify other non-binary peoples' experiences, and they don't define mine. Binary people do not get to define my or anyone else's non-binary experiences. I have the right as a non-binary person to refuse to accept people brushing me or any other non-binary person under the fucking carpet because our existences complicate their inaccurate (mis)understandings of gender. I am real. I exist. I am valid. I am real. I exist. I am valid."
"Tell the chef, the beer is on me."
"Basically the price of a night on the town!"
"I'd love to help kickstart continued development! And 0 EUR/month really does make fiscal sense too... maybe I'll even get a shirt?" (there will be limited edition shirts for two and other goodies for each supporter as soon as we sold the 200)


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Home > accessories > Stainless Steel Filters and Strainers
Stainless Steel Filters and Strainers
Stainless Steel Filters and Strainers Catalog
Stainless Steel Filters and Strainers Specifications:
Alloy: T316L
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Finish: Polish to 32 Ra Finish ID/OD or better
Stainless Steel Filters and Strainers
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SSPMO-3.025" ID-30-3/4"Length- x 0.033" Hole---- LONG Perforated Metal Over screen
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Key Focus Areas
Imagine students totally engaged in hands on math activities where they calculate the number of seeds on a kale plant that they watched grow, flower and go to seed. Over the period of a few afternoons, without even realizing it, students were learning big ideas of how data can be collected, organized and displayed in order to address questions that emerged from time in the school garden. Their class regularly went to the garden to harvest kale for the weekly salad bar. The salad bar incorporates local produce from a number of local farmers and is supported by parents and students from a culinary arts program at a nearby secondary school. The creation of a school garden and weekly salad bar program was supported by the whole school community as part of a whole school food policy. This policy was developed by students, teachers, administrators and staff, and parents to go beyond the requirements outlined in the Guidelines for Food and Beverage Sales in BC Schools to try to create a culture of food literate students.
Food literacy is having the knowledge, skills and attitudes necessary to choose, grow, prepare and enjoy food to support one's health, community, and the environment. Food literacy is about healthy eating, but food is also connected to competencies and concepts in the Physical and Health Education curriculum as well as other curriculum areas.
How is Food Literacy Connected to Comprehensive School Health?
A comprehensive school health approach (often called a whole school approach) to food literacy is about ensuring students have many opportunities – in the classroom, and in every aspect of their school experience – to develop food literacy. Students' learning is enhanced when learning experiences extend beyond the classroom throughout the school and into the community. A comprehensive school health approach coordinates actions across all areas of the school in a planned, integrated and holistic way. Incorporating the pillars of comprehensive school health, as outlined in the links below, supports the development of food literate students in healthy school communities.
Click here to learn more about each distinct yet inter-related pillar and to find programs and resources that support each pillar of a comprehensive school health approach to food literacy.
There is no one right way to engage your students and community to foster food literacy. It will look different in each school depending on your unique context and surrounding community. It is possible to begin work in any one of the pillars. There are a variety of programs and resources that collectively support healthy eating and food literacy. Schools can use one or more of the initiatives to address the mutually reinforcing pillars of a comprehensive school health approach to food literacy.


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But as you will see in a even though, all of the Beatles kids have managed to lead – if not regular – exemplary lives in spite of getting in the shadows of their popular fathers by default. The game has players helping Jojo style stylish outfits for your models to showcase in some of the largest style shows in the planet. It is a game that could really spur a player on to grow to be a career style designer in the future. We are incredibly grateful for your commitment to Sojourner and for generating this sold out show such a wonderful accomplishment! Placing on a Fairtrade cotton Fashion Show is an exciting and inventive way to construct support for Fairtrade cotton clothes in your college. I have $14,851 Mall Planet Bucks and that is all because of the wheel of fourtune.
If u want the garments that arent i the retailers go to 1 of your close friends homes develop a look for them and place the clothing that they do not sell in the shops that u want then save it then go to yr property for a minute or two the go bac to ther retailer click ther appear book and the appear u did will be in ther and u can get it from ther its fairly simple it relly performs i promis and by the way im only 11 yeARS OLDDD!!!!!!!
A delightful fashion show with 2 and four legged models in current and creative modern fashion will culminate with a live auction. Whilst the game says you need to employ more safety guards, I never ever truly bother and as an alternative focus on the mall look aim. This indicates that there is plenty of gameplay to discover and hours of playtime in Spirited Heart. Biasanya dilakukan pagi-pagi sebelum mall buka karena ya, kalau mall sudah buka kan ada pengunjung.
Gaultier's collection is rich in components like embroidery, lace, tulle, feathers, velvet and satin. There are bridges and escalators outdoors that connect the Fashion Show mall, Wynn Las Vegas, Venetian and Treasure Island. There are great ad-on enjoyable tools in fashion games that can be used to create or boost apparel fashionable clothes designs. It undoubtedly leans a lot more towards the style side of factors so you are going to want to have a keen eye for trendiness if you want to achieve the prime ranks on IMVU. Whilst this is happening, employ further janitors and max out the mall decoration by placing plants everywhere.
What you create in a mall scenario will carry on to later levels in that same place. There's the entertaining of knowing about fashion runways and its value in the worlds most glamorous profession of fashion style. If you need to have more inspiration prior to you can program your fashion show, check out these videos of past IADT Tampa runway events, and interviews with the students and faculty members who created them take place.


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Get Involved
With many new projects in the works, Kollaboration DC is seeking talented members of the community to join our core staff!
Click on the link below for a list of brief job descriptions of our current openings. You are welcome to apply for as many positions as you'd like as long as you provide us a ranking of your preferences. Please be aware that a staff role with Kollaboration DC also requires a significant time commitment so please consider your ability to fulfill the requirements of your desired position and attend regular staff meetings in addition to various community events throughout the year. However, if you're ready and willing to become part of the movement, an amazing and thrilling experience awaits you!
To Apply, please submit the following documents to email@example.com
- A brief statement of intent introducing yourself and answering the following questions (Why Kollaboration DC? What can you bring to the team? What are you looking to get out of the experience?)
- Your current resume
- Your list of job preferences
Decisions will be made on a rolling basis so please submit your applications ASAP.
Basic Requirements
Before applying, please look over the basic requirements below. Kollaboration DC is run entirely by a staff ranging from students to professionals. Accountability and responsiveness are key to a successful season. Depending on the position and its specific responsibilities, the time commitment required may vary. However, for all applicants, we are looking for individuals who:
- Have a passion for the Asian and Pacific Islander community both locally and nationally
- Commit to be a part of the KDC team for the entire Kollaboration season
- Are willing to put in at least 2-10 hours of work a week and fulfill all assigned responsibilities (this time commitment will ramp up as major events (such as shows) & project execution dates approach)
- Participate in all staff meetings and conference calls
- Participate in as many Kollaboration Sponsored Community Events as possible
- Be able to attend the all-staff kickoff meeting (tentative date: Early-March)
Questions? Direct all inquiries to our Director, Betty Wong at email@example.com.


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note giulienk I try a solution: untested code ahead.  use IO::File; my $fh = IO::File->new_tmpfile; $image->Write(file => $fh); seek($fh, 0, 0); $ftpSession->put($fh, $filename);  The temporary file will be erased as you close it. It's in someway as it never existed and it's just useful to pass a filehandle to the [kobe://Net::FTP] <tt>put</tt> method instead of a scalar (that the method doesn't accept).

<TT>$|=$_="1g2i1u1l2i4e2n0k",map{print"\7",chop;select$,,$,,$,,$_/7}m{..}g</TT> 168449 168449


text: Can Election Results Predict the Market? How do the markets usually react to elections? Was the 2016 election any different? Share | Have A Question About This Topic? Name Email Address Message Thank you! Oops! Related Content Emerging Market Opportunities What are your options for investing in emerging markets? The Ivory Tower Changes Wall Street Thanks to the work of three economists, we have a better understanding of what determines an asset's price. Keys to Investing for Retirement There are some key concepts to understand when investing for retirement.


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Posted on September 17, 2014
Designing and maintaining a high-performing infection prevention program requires executive support, alignment with the strategic goals and objectives of the organization, and development of collaborative partnerships with clinical and ancillary support services. Key programmatic components include:
Leadership support–Establishing a supportive infrastructure and an adequate budget for a high-performing infection prevention program requires involvement at the highest levels of a healthcare organization's leadership. An Infection Control Committee that includes medical and nursing leaders will ensure endorsement of the program's goals and objectives with the clinical staff.
Multidisciplinary team involvement–Implementation of a high-performing infection prevention program requires participation from individuals across the healthcare organization–from senior leadership to environmental services staff. Clear responsibilities for all staff must be established and each person needs to have an understanding of the importance of his or her role in reducing infections.
Adequate staffing of trained Infection Preventionists–Healthcare organizations have responded to the increased focus on infection prevention and control by devoting greater resources to IP. While some smaller acute care and many long-term care facilities still have part-time IPs, healthcare organizations are increasingly recognizing the need for at least one full-time IP with formal training. Depending on the size of the organization and the demographics of the patient population, substantially larger and more diverse teams of professionals may be appropriate for IP.
General staff and patient education–Engagement of healthcare workers requires annual education in the basics of infection prevention and the organization's policies and procedures related to infection prevention, as well as inservicing on policy updates and new technologies implemented to minimize infection risk to patients. Patients should be educated upon admission of the infection prevention practices that their healthcare workers should be following to prevent the transmission of infection, such as handwashing. Patients infected with multi-drug resistant organisms (MDRO) such as Clostridium difficile or other communicable diseases should receive specific education on their role in preventing transmission to others.
Evidence-based policies and procedures–Evidence-based policies and procedures should include hand hygiene, care of invasive devices such as urinary catheters, sterilization and disinfection, and environmental cleaning. Specific guidelines for MDRO screening and isolation policies should be written and accessible to all staff.
Surveillance of HAI outcomes and processes targeted at infection reduction should include established, timely feedback mechanisms and well-communicated metrics for success. Automated surveillance systems receive real-time data feeds from admission/discharge/transfer, lab, pharmacy, radiology and surgery to identify patients at risk for HAIs and flag patients who require isolation management. This real-time monitoring allows trending of key metrics rapid intervention by the IP.
Outbreak management–Rapid detection of outbreaks is essential to prevent ongoing transmission of the potential pathogen to other patients, visitors and healthcare workers. A high-performing infection prevention program establishes the endemic rate of sentinel organisms in the facility and monitors for adverse trends.
Employee health partnership—It is essential that employees infected with communicable diseases adhere to the work restrictions dictated in the organization's Employee Health policies and procedures to protect patients, visitors and other healthcare workers. Additionally, the healthcare workers will be screened for immunity to communicable diseases upon hire, and may be required to receive vaccinations e.g. measles, mumps, rubella or varicella vaccine as recommended by the CDC, the Advisory Committee on Immunization Practices (ACIP) and the Healthcare Infection Control Practices Advisory Committee (HICPAC). Further, healthcare workers are strongly encouraged to receive annual influenza vaccinations and may be required to be vaccinated to retain employment. Influenza vaccination compliance reporting is mandated by CMS for most types of healthcare facilities.
Antibiotic stewardship–High performing infection prevention programs include an antimicrobial stewardship (AMS) component that monitors antimicrobial agent selection across the institution and tracks patterns of antimicrobial overuse as well as emerging resistance and bug/drug mismatching. Members of the AMS team provide content information to clinicians on best practices for antimicrobial dosing and administration. The data captured in an automated surveillance system aids the development of MDRO reports and antibiograms to display susceptibility profiles for specific organisms by source and location.
Public health reporting–High-performing infection prevention programs are familiar with local, state, and federal public health reporting requirements and ensure timely reporting.
Are there other elements you would include in an infection prevention program? We'd love to hear your additions below.


text: Share: Comments Print June 12, 2013 at 12:59 PM Catching up on a few links Posted by Bob Condotta Time to catch up on a few links. … — The NCAA released the annual APR scores Tuesday, and it was good news for UW. Bud Withers wraps it up here; — ESPN.com's Ted Miller notes that the entire Pac-12 turned out safe; — Former UW receiver Jamaal Jones is transferring to Montana; — ESPN letting you vote if you think UW's offense will rebound this season. Comments


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Artifact Details
TitleNP-complete problems
Catalog Number102624710
TypeMoving Image
CreditsKarp, Richard
PublisherUniversity Video Communications
FormatBetacam SP
Copyright HolderComputer History Museum
DescriptionFrom University VIdeo Communications' catalog:
"ACM's A.M. Turing Award winner Richard Karp clearly defines NP-complete problems. A combinatorial search problem involves searching through a finite, but very large, set of possible patterns or arrangements for one that satisfies a stated set of constraints. Despite decades of effort, many important combinatorial search problems seem intractable, since every known algorithm for their solution experiences a combinatorial explosion in running time as the problem size increases."


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The Pueblo Rangers organization was founded in 1982 by a group of individuals who had a dream of developing soccer in Pueblo to be competitive with others across the state and the nation. A board of directors was formed by team representation and they worked to develop club uniforms, structured tryouts, fund raising activities, the development of soccer fields and our club newsletter.
From 1982 to 1995, league games were played primarily at local high school fields. In 1993, an official presentation of $10,000 was made to the City of Pueblo for the development of a soccer complex. In the spring of 1996, we had four complete fields at the 24th Street "Langoni" Complex. We have gone from 1 team to 160 teams and approximately 1500 players with boys and girls teams in every age group. In 2002 the Pueblo Rangers added U-10 Intermediate league soccer to assist young players with the transition from recreational soccer to advance league soccer. In 2016 the Rangers introduce TOPSoccer. TOPSoccer is a nation wide program for children with special needs. It is funded by the Pueblo Rangers and donations from local business. TOPSoccer provides a real soccer experience for those children who would otherwise not be able to participate in standard soccer programs.
We have also added professional soccer education. In December 2003, the Rangers hired a professional Director of Coaching to direct and educate our coaching staff and work in southern Colorado to advance the sport of soccer. In the fall of 2004, at the request of local teams, the Rangers added recreational soccer for ages 3 - 12 and then the following spring pioneered the concept of Middle School Soccer for 6th to 8th grade students. The middle school league resulted in the addition of 20 teams from Pueblo's middle schools. The Pueblo Rangers will continue to enhance the soccer experience of Pueblo's youth players and with the continued dedication of the new generation of board members and parents, we can look forward to expanding our soccer program and our soccer complex. From the days of lining fields with tiny cans of spray paint and homemade corner flags to the wonderful complex we are now enjoying. In July of 2017 we purchased 28 acres of land just south of the Cesar Chaves Academy on the north west side of the city. The site will be the new home for the Pueblo Rangers Soccer club including our administrative office and sports facilities.
We would like to express our gratitude to all of those who made all of this possible: past and present officers, board members, coaches and parents!


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127 Willow Grove Mill Drive, Middletown, DE 19709-8631 $439,999
Interior Sq. Ft: 4,500
Acreage: 0.35
Age:18 years
Colonial, Contemporary
Mobile#: 8515
Subdivision: Longmeadow
Stunningly Beautiful!!! This Luxury Estate Home is nestled on a picturesque tree lined street and sits on a third of an acre in the highly desirable Longmeadow. This gem exhibits quality craftsmanship with all its recent upgrades and exudes a timeless elegance with modern amenities and convenience. Step into the dramatic 2-story entryway with 2 coat closets on either side of the custom 8 foot Rustic Tuscany door finished with calves and strap hinges with Rainglass sidelights. The gracious 19'x12' foyer is complete with shadow boxes and a focal point of an open staircase, one of two, and is flanked by a formal living room to the left and a formal dinning room to the right that has also been embellished with a chair rail and shadow boxes. Both rooms are adorned with large windows on all exterior walls that brightens these rooms with natural light. Further into the home you'll find a study/office with a ceiling fan and a wood-trimmed entry, an elegant 2-story family room with a ceiling fan/heater with a wall of windows and a marble gas fireplace, a powder room, a huge coat closet, 15'x7' mudroom with a storage closet & cabinets and a magnificent chef's kitchen. The kitchen is a gourmet cook's delight featuring 42" staggered soft close Duncan Espresso cabinets, some glass, with crown moulding, recess lighting, custom 7'x4' island with a built in microwave drawer and a trash cabinet, 4 industrial chic pendants, a large pantry, 5 burner gas stove with dual ovens and a bluetooth connectivity and wi-fi monitoring wall mount chimney range hood, a one piece 36" farmhouse curved apron sink with an industrial single-handle pull-down sprayer faucet, granite counters, stainless steel appliances and to top it off, a libation enthusiast center. The piéce de résistance is the 33'X24' split deck with LED deck lights, outdoor speakers and a large canopy for outdoor entertaining. The entire first floor and both staircases have Hand-Scraped engineered hardwood floors (except the mud room), and just as visible through out the first floor is the double edged crown moulding, shadow boxes and trim work, dimmable recess lighting with LED daylight bulbs and custom paint. Ascend to the upper level of the home using the front or back staircase embellished with rod iron spindles to a lovely "cat-walk" complete with crown moulding. On this level is the master suite, that's accessed through double doors, with his and hers walk-in closets, a ceiling fan and a 15'x7' retreat. The master bath has a water closet with a linen closet and window, a jetted over-sized tub, a stand alone shower and double sinks. The second floor also features three large bedrooms with ceiling fans, a hallway linen closet and a hallway bath with its own linen closet. The story of this home continues with a finished lower level flooded with recess lights (LED Daylight Bulbs), a large family/miscellaneous room with dedicated sections for a workout/play area. Waiting for your finishing touches is a tiled area that has been pre-plumbed and pre-wired for a future bar. For your overnight guest there's a room that can be used as a bedroom with a large closet and full bathroom. There's also an unfinished storage space and a French door with built-in blinds that leads up to the beautiful oasis and peaceful sanctuary of the rear yard lined with mature Layland Cypress trees and has a 10'x12' A-Frame Shed with black doors, trim and shutters. The 2-Car Turned Garage with a ceiling storage rack is painted to compliment the interior of the home. This beauty is located in the rapid growing Town of Middletown with the highly appointed Appoquinimink School District and is close to all major routes, shopping, dining, pubs and more. It's only 90 minutes away from the Delaware Beaches. Schedule your appointment today! *Sellers are offering a 20k credit with a full price offer towards stucco replacement/repairs.**Note: Square footage & room dimensions are approximated**Seller is a licensed DE agent*
Dining Room: 14 X 13 - Main
Family Room: 20 X 14 - Main
Living Room: 15 X 14 - Main
Office: 13 X 13 - Main
Mud Room: 15 X 7 - Main
Foyer: 19 X 12 - Main
Bedroom 2: 14 X 12 - Upper 1
Bedroom 3: 13 X 13 - Upper 1
Bedroom 4: 12 X 11 - Upper 1
Basement: 46 X 31 - Lower 1
Additional Bedroom: 19 X 17 - Lower 1
Home Assoc: $125/Annually
Condo Assoc: No
Basement: Y
Pool: No Pool
Elem. School: Brick Mill Mid. School: Louis L.Redding.Middle School High School: Middletown
HOA: Yes;
Forced Air Heating, Natural Gas, Ceiling Fan(s), Central A/C, Electric, Natural Gas, Public Water, Public Sewer, 200+ Amp Service, Circuit Breakers, Main Floor Laundry
Attached Garage, Off Street, On Street, Additional Storage Area, Garage Door Opener, Garage - Side Entry, Inside Access, Attached Garage Spaces #: 2;
Attic, Breakfast Area, Ceiling Fan(s), Chair Railings, Crown Moldings, Additional Stairway, Full Basement, Fully Finished Basement, Outside Entrance Basement, Basement Walkout Stairs, Carpet Flooring, Ceramic Tile Flooring, Hardwood Flooring, Laminated Flooring, Gas/Propane Fireplace, Marble Fireplace
Pitched Roof, Shingle Roof, Aluminum Siding, Stucco Exterior, Vinyl Siding, Deck(s), Flood Lights, Sidewalks, Street Lights
Corner Lot/Unit
Select a school from the following list. Schools are grouped by school type.
The schools on this list are selected by their proximity of up to 5 miles to the property address. Proximity does not guarantee enrollment eligibility. Please contact the school directly for more information on enrollment requirements.
* If there are more than 5 schools of any type within a close proximity, click on the button to see additional schools of that type near the search address.
Public Elementary (8 schools)
|Brick Mill Elementary School
|Appoquinimink School District
|1.05 mi
|Silver Lake Elementary School
|Appoquinimink School District
|1.68 mi
|Bunker Hill Elementary School
|Appoquinimink School District
|3.05 mi
|Townsend Early Childhood Center
|Appoquinimink School District
|3.32 mi
|Mot Charter School
|Mot Charter School
|3.48 mi
|Cedar Lane Elementary School
|Appoquinimink School District
|3.96 mi
|Cedar Lane Early Childhood Center
|Appoquinimink School District
|4.12 mi
|Old State Elementary
|Appoquinimink School District
|4.46 mi
Public Middle (4 schools)
|Redding (Louis L.) Middle School
|Appoquinimink School District
|1.58 mi
|Meredith (Everett) Middle School
|Appoquinimink School District
|1.79 mi
|Mot Charter School
|Mot Charter School
|3.48 mi
|Waters (Alfred G.) Middle School
|Appoquinimink School District
|3.86 mi
Public High (3 schools)
|Middletown High School
|Appoquinimink School District
|0.84 mi
|Appoquinimink High School
|Appoquinimink School District
|3.14 mi
|Mot Charter School
|Mot Charter School
|3.48 mi
Private (3 schools)
|St Annes Episcopal School
|0.69 mi
|St. Andrew's School
|0.78 mi
|Tender Loving Kare Childcare & Learning Center Ii
|2.81 mi
© 2019 Onboard Informatics. All Rights Reserved.
This report is a detailed community overview for Middletown(19709), Delaware.
Community Quick Facts
- Daytime population in this area: 28,470
- Average travel time to work for people in this community: 31
- Average salary of people in this community: $51,800
- Closest Major Airport: New Castle
- Closest Major Sports Teams: Wilmington Blue Rocks (A)
Community Summary
- Population Growth (since 2010): 22.82%
- Population Density (ppl / mile): 542
- Household Size (ppl): 3.01
- Households w/ Children: 40%
- Annual Residential Turnover: 0%
Housing Inventory
- Owned: 11,721 (79.1%)
- Rented: 2,461 (16.6%)
- Vacant: 638 (4.3%)
- Total: 14,821
Population Demographics
The population of the community broken down by age group. The numbers at the top of each bar indicate the number of people in the age bracket below.
Climate and Weather
The Temperature chart displays average high and low values for January and July, and is designed to provide an indication of both seasonal and daily temperature variability. The Weather Risk Index indicates the calculated risk of each type of weather event occurring in the future. This risk is based on historical localized storm events and weather patterns. The national average for each type of weather event equals a score of 100, so a score of 200 would represent twice the risk as the national average, and a score of 50 would represent half the risk of the national average.
The Community Educational Index chart is based on the U.S. Census Bureau's Socioeconomic Status (SES) elements. Factors used in creating the index below are income, educational achievement, and occupation of persons within the selected ZIP code. Since this index is based on the population of an entire Zip code, it may not reflect the nature of an individual school.
Educational Climate Index: 3 (1 = Low, 5 = High)
Highest Level of Education Attained
- Less than 9th Grade: 2.3%
- Some High School: 4.5%
- High School Graduate: 28.6%
- Some College: 22.1%
- Associate Degree: 8.5%
- Bachelor's Degree: 21.3%
- Graduate Degree: 12.7%
- White Collar: 62%
- Blue Collar: 38%
Income by dollar range
Median Income: $93,037
Fair Market Rents
The Fair Market Rents show average gross rent estimates based on figures provided by the U.S. Department of Housing and Urban Development (HUD).
- Studio: $845
- One Bedroom: $1,003
- Two Bedroom: $1,211
- Three Bedroom: $1,515
- Four Bedroom: $1,686
The Crime Index compares the risk or probability of future occurrence of certain types of crime in this community as compared to the national average. The national average for each type of crime equals a score of 100, so a score of 200 would represent twice the risk as the national average, and a score of 50 would represent half the risk of the national average.
© 2019 Onboard Informatics. All Rights Reserved.
Contact Information
Schedule an Appointment to See this Home
Request more information
or call me now at 302-234-5195
Listing Courtesy of:
The data relating to real estate for sale on this website appears in part through the BRIGHT Internet Data Exchange program, a voluntary cooperative exchange of property listing data between licensed real estate brokerage firms in which Patterson-Schwartz Real Estate participates, and is provided by BRIGHT through a licensing agreement. The information provided by this website is for the personal, non-commercial use of consumers and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing.
Information Deemed Reliable But Not Guaranteed.
Copyright BRIGHT, All Rights Reserved
Listing data as of 12/12/2019.


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Former Shorten staffer (and another Canberran) looking for love on 'The Bachelor'
She's used to high stress, working late nights and being under the intense scrutiny of the media - so could Alisha Aitken-Radburn's experience as a former Bill Shorten staffer have been the ultimate preparation for success on The Bachelor?
The 25-year-old political adviser - she worked as an 'advancer' for Shorten on and off for two years between 2016 and March of this year - will vie for the affections of new Bachelor and former rugby union star Nick 'The Honey Badger' Cummins in the new series of Ten's reality show.
While she no longer works for the opposition leader, Aitken-Radburn has given Shorten and his office the "heads up" that she's appearing on the show, and is expecting her political connections to open up a new and incredibly high profile audience for The Bachelor.
"[Shorten's] office has been great, they've been really good," Aitken-Radburn, 25, says.
"I reckon everyone from Barnaby to Malcolm to Bill, everyone's gonna be watching on Wednesday night, I'm sure of it, because it's going to be an unmissable season.
"All the guys are going to be getting around it because of the honey badger and now I feel like everyone in the press gallery is going to be watching as well."
Tired of looking for love at Public in Manuka and on the ground floor level of Mooseheads - "isn't that where everyone in Canberra goes to find romance?" - Aitken-Radburn decided to try her luck on the show.
"I've tried Tinder, tried internet dating - but I feel like in the scheme of modern dating The Bachelor is a pretty great route," she says.
She's already got the hots for former Western Force player and Bachelor Cummins - "he's a good-looking rooster" - and is "totally into" his much-criticised 70s-style curls and patchy moustache.
"Working in politics, I'm not surrounded by elite sportsmen so when I first saw Nick, I got out of the limo and I was really pleasantly surprised," Aitken-Radburn says.
"I think it's really refreshing - he's a normal guy, he's very down to earth. I'd definitely sidle up to him at Mooseheads."
But securing even five minutes of Cummins' attention won't be easy. Aitken-Radburn is up against 25 women vying for the sports star's affection, including, as luck would have it, another Canberran.
Cook resident Emily Dibden, 24, a teacher at the National Capital Ballet School and model is also looking for love on the new season of the reality show. Dibden is a former Maxim cover girl and, in a bizarre and typically Canberra twist, the housemate of Meghan Markle lookalike Stephanie Murray.
Dibden knows the show will raise her profile nationally (and maybe internationally) but is looking to "put myself out there again" after what she describes as "a pretty rough breakup".
"I just thought why not? And getting the call was mind blowing."
While she didn't know much about Cummins before the show - "although I'd seen a few of his videos online and thought he was a total crack up" - she's keen to fall in love. But on one condition. Cummins will need to move to the ACT if he wants a future with Dibden.
"I'm just a proud Canberran girl - I love Canberra, I love that I'm from Canberra and I love how supportive Canberra is - I just love the whole deal," she says.
"So for [Alisha and I] to be able to represent our home town [on the show] is just really fab."
The Bachelor premieres this Wednesday, August 15 at 7.30pm on Ten.


text: 1. Proceedings, Conference of Preventive Medicine Officers: Preventive Medicine Service, Office of the Surgeon General : 14-15-16 February 1945, Johns Hopkins University, School of Hygiene & Public Health, Baltimore, Maryland Author(s): Conference of Preventive Medicine Officers (1945 : Baltimore, Md.) author. Publication: [Washington, D.C.] : Preventive Medicine Service, Office of the Surgeon General, [1945?] Subject(s): Military MedicinePreventive MedicineWorld War IIUnited States


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The Emmy winner tells The New York Times comments like those set a bad example for impressionable girls
Melissa McCarthy has won over audiences with her comedic performances and warm Midwestern charm, but the Oscar-nominated actress admits that a scathing film review earlier this year that referred to her as "tractor-sized," could have a negative impact on young girls who might not conform to the traditional definition of Hollywood beauty.
In an new interview with The New York Times, McCarthy spoke out for the first time about the criticism, saying her initial reaction was "Really?" followed by, "Why would someone O.K. that?"
The review – written in February by Rex Reed of the New York Observer, who panned the film Identity Thief and called McCarthy a "female hippo" and a "gimmick comedian who has devoted her short career to being obese and obnoxious" – drew criticism nationwide.
McCarthy, 42, said that if the review appeared when she was 20, "It may have crushed me." But now, in "a strange epidemic of body image and body dysmorphia," she said comments like that "just add to all those younger girls, that are not in a place in their life where they can say, 'That doesn't reflect on me.' "
Controversy aside, McCarthy enjoys a robust career and family life with husband Ben Falcone and daughters Vivian, 6, and Georgette, 3 – even if she admits to feeling "intensely guilty" as a working mom.
"I just thought, that's someone who's in a really bad spot, and I am in such a happy spot," said McCarthy, who next appears in The Heat alongside new pal Sandra Bullock. "I laugh my head off every day with my husband and my kids who are mooning me and singing me songs."


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So I went out of town last weekend and before I left, I put out another litter box for my kitties. As I was filling it with litter, Thurston walks in all casual-like, sits and watches. As I explain that he has a new clean litter box (yup. . .I talk to them like they… Continue reading Random Funny.
Tag: beginner blog
Did you miss me?? Haha! Every once in a while something happens that lights that creative fire and then...I write. This time it was a simple text from my mom. Telling me she is thankful every day. Ten years ago, my life was unrecognizable. Bad choice after bad choice, disappointing my friends, my family. I… Continue reading Thankful
9 of the best internet pics when you just need to laugh.
So things have been a little busy at work for me lately and I really haven't had the creative energy to put together any really great posts. Or even any mediocre posts. I totally should have documented my husband and I putting together a gazebo in the backyard. Although this was one project we made it through without… Continue reading 9 of the best internet pics when you just need to laugh.
7 Tips for a Wonderful Weekend Getaway to Carmel.
I'm sure there are plenty of people out there who know Carmel better than I do. Up until a few years ago, I had never even been. *gasp* I know. . .it's hard to believe. Carmel is an absolute gem of a town! So lovely, in fact, that my husband and I decided to get married… Continue reading 7 Tips for a Wonderful Weekend Getaway to Carmel.
Animal testing.
So. . .I just saw the Facebook video of the animal testing being done at Texas A&M laboratories (came out in December, so maybe you've already seen it). I hate this feeling. The overwhelming sadness and crippling helpless feeling. The problem is so big, what can I do about it? Something. Anything. I'm not going… Continue reading Animal testing.
Thurston, aka "Nasty Cat"
As some of you may know, I have three wonderfully sweet kitty babies. Now "wonderfully sweet" really only applies to me, and sometimes my husband, as they are either rude or fearful of most others. Unfortunately, today we had to go to the vet. I will spare you the gruesome details, but cats have anal… Continue reading Thurston, aka "Nasty Cat"
Finally. . .makeup success!!!
Finding makeup that really works for me has been a serious struggle. And I'm sure this struggle is not solely mine. There are SO many options and all the commercials make it look so simple and wonderful and just put it on and tra la la. I'd hate to see how much time I've wasted… Continue reading Finally. . .makeup success!!!
Another delicious cobbler recipe. Yum!
I had another couple bags of frozen peaches leftover from my previous cobbler recipe post. You can check that out here if you missed it. I also had a box of pie crust mix so I decided to throw it together and see how it turns out. I started with the peaches and added some… Continue reading Another delicious cobbler recipe. Yum!
ASMR you hearing this??
I promise that all of my blog posts from this point on will not start with "So I was listening to this podcast". I do have original thoughts, I'm just really on a podcast kick right now and sometimes they give me ideas. So. . .I was listening to this podcast (haha!), and this woman was talking… Continue reading ASMR you hearing this??
Corpses and spirits and sex. . .oh my.
Are you as curious as I would be at that title? Oh boy! Don't worry, those things don't actually go together. At least. . .they shouldn't. Anyways, these are all topics of books written by one of my favorite authors, Mary Roach. Her style of writing mixes scientific study and humor (two things that you don't often think… Continue reading Corpses and spirits and sex. . .oh my.


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Two Bright Fake Cartier UK Watches Draw Attention Of Ladies
Diamonds have deep attraction to women, so when the dazzling replica Cartier watches sales best are integrated with diamonds and white gold, they are quite popular. With square shape, the modern Cartier fake Swiss watches reflect the decent effect. With… Continue Reading


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'Return on investment' his catchphrase as two-day education panel meeting begins
Getting a good return on the state's investment was Gov. Rick Scott's catchphrase Wednesday as he pushed universities to measure college students' performances.
Scott said he wanted to measure whether students found jobs or went on to get more education after college, what their salaries were and how much their degrees cost.
"Everybody in our state pays taxes," he said to a room of university presidents and state educational leaders Wednesday in Sarasota. "This is their money. They want to get a return . . . We ought to allocate the money based on returns."
The discussion of tying students' performances to funding public universities was one of the issues brought up Wednesday during the Florida Board of Governors meeting. The board, which oversees the 12 public institutions, began a two-day meeting Wednesday at the New College of Florida.
But Florida State University President Eric Barron questioned whether Scott's metrics were too narrow, pointing to students who study fine arts or education as an example.
"We know they're extremely talented people and they go into fine arts because they're gifted and this is what they want to do with their lives. Yet their salaries are very low," Barron said.
The governor, who vetoed tuition increases earlier this spring, maintained his stance against raising the prices for school during Wednesday's meeting.
"I'm concerned about tuition. I think it's positive our tuition is lower than in other states," Scott said. "I don't believe we ought to be raising tuition."
Later in the meeting, the governor's task force presented its recommendations on higher education reform, which included changing how students pay for school.
Instead of charging the same tuition rate for all students, universities should charge different amounts based on degrees, said the task force's chair, Dale Brill, who delivered his presentation after the governor had left.
The different tuition rates would push students to high-skill, high-wage, market-driven bachelor's degrees, which could include so-called STEM programs — science, technology, math and engineering. Tuition for those high-demand job majors would get frozen under the task force's proposal.
"When we look at high demand, we're not necessarily talking about volume," Brill said.
Certain majors may be "important to this state" without having thousands of job possibilities, Brill said.
Brill also said that overall tuition increases should be "only as a backstop" if the state does not adequately fund public institutions.
But board member Ava Parker said she saw a "direct conflict" between the governor refusing to raise tuition and the Legislature's "belief there would be a great contribution from families."
"To say, 'OK Legislature, fund it,' we know that's not going to happen because we just don't have the money," said Parker, of Jacksonville.
The task force recommended evaluating Bright Futures scholarships and studying whether the program needed changes.
"It may have been great at its time," board member Norman Tripp said. "But is it now putting money into the hands of people who don't really need it? And the middle and lower class, are they being frozen out?"
The next step is for the task force to deliver its report to Scott within the next few days.
"I'm glad that we're having all these conversations," Scott told reporters after the meeting. "I look forward to reading the report from the Blue Ribbon Task Force."


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As the wedding is 15 days away (OHMYGOODNESS) I am trying to stay on track so that my very unforgiving wedding dress will fit come "I Do" day. Road trips always used ot be my excuse to pig out on fast food. I loved a Hardee's Chicken Biscuit or grabbing a Dary Queen Blizzard. Well, no more. No more poison and no more crap. To fuel our journey I've packed mostly Paleo goodness that I hope my ladies will enjoy as much as I do. On board for this weekend is:
- Bananas
- Coconut water
- Water water
- Organic apple sauce
- Dried peaches
- Potato chips cooked in olive oil
- Lightly salted, roasted almond,
- Larabar
- Pecan crackers
- Dark chocolate PB (all natural atleast)
- Pork Rinds, oh yes, we're going there!
- Organic beef jerky and turkey jerky
- Apple Cider Vinegar for general wellness, vitamins and fish oil
Yum yum! What do you like to travel with when traveling and keeping it clean?


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Podcast: Play in new window | Download (Duration: 47:17 — 43.3MB) | Embed
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I approached Stu about doing this interview after one of his shows in Toronto. It was the 2nd time I'd seen him perform and I was so blown away by the experience that I knew I needed to find out what makes him, him.
After we recorded this episode I sat in silence for a long time, reflecting on everything we talked about and his life and story as a musician and world traveller. He truly is the sort of person that makes you stop and take a deep breath. His love of creating music and capturing the world around him is so pure, as is the joy he gets out of simply being alive.
I urge you to not only listen to every album he's made (if you haven't already), but to every word of this conversation. There is so much beauty and honesty in what he has to say and his perspective and outlook on life just may change your own.
As promised, here is the link for candidates looking to sign up at HiredHippo: https://bit.ly/2UiHV1J
If you're an employer looking for your next great hire, head to https://signup.hiredhippo.ai/employers/ and enter promo code MADEFORTHAT for a 50% discount for a year with the option to cancel at any time. If you'd like a free trial, you can email the CEO directly at firstname.lastname@example.com with the subject line MADEFORTHAT.


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Displaying : (1 - 10) of 120 In : Events
We are committed to providing our members and Victorians with a wide range of opportunities to safely participate paddling by offering services in four key areas of paddling Competition, Recreation, Education and Experiences.
Website : http://vic.canoe.org.au
A collection of Outdoor Recreation Industry, Adventure Travel, Adventure Sport, Outdoor Employment, Education and Training, Equipment, Classified Advertising and General Interest News from around the globe relevant to Australian and New Zealand outdoors and adventure.
Website : http://www.adventurepro.com.au/news
The AdventurePro Video Film Festival presented by the Australian Camps Association is open to any video between 2 - 15 minutes featuring Australian & / or New Zealand Outdoor Adventure --- or, Aussies and Kiwis adventuring overseas!
Short, fast and fun, and suitable for anyone and everyone with a real sense of and adventure, the series is designed to offer the perfect introduction to the exhilarating sport of adventure racing.
Website : http://paddypallinadventure.com.au
Adventure sports event management, MTB, Off-road triathlon, adventure racing, corporate team building. Participation in environment & community.
Website : http://in2adventure.com.au
Australian Mountain Biking
Website : http://www.rotorburn.com
Gary Sutherland & Ray Deetlefs have over 20 years experience competing in adventure races globally. Their passion for adventure racing is now being directed into filling the gaps in the adventure racing calender with courses to deliver all participants with a challenging adventure within their endurance and skill level.
Website : http://www.ridgelineadventures.com.au
Isn't it time you stopped guessing the weather? Get all your weather in one place, live conditions, hourly and 7 day forecasts, plus our famous 12 month precast - a world first service!
Website : http://www.eventweather.com.au
Mt Baw Baw is an all season alpine resort, open year round for summer and winter adventure! The resort caters for snowboarders, skiers and snow enthusiasts during winter and outdoor adventurers, hikers and bike riders during the summer months. Your Mt Baw Baw adventure is merely a 2.5 hour drive from Melbourne.
Website : http://mountbawbaw.com.au
Adventure racing is a great mental and physical challenge and a fun way to explore the great outdoors. Our races are versatile events that are suitable for beginners while offering a significant challenge to experienced competitors.
Website : http://boundless-ar.com.au


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From Juliet at the Enterprise Group, Transition Town Lewes…
Is the depth of a recession a bad time to ask people to think about creating sustainable enterprise – or is it a truly inspired time to encourage people to think about building their own resilient livelihoods?
With national employment remaining stagnant – and youth unemployment continuing to rise – there may seem little choice about timing. Lots of people are realising they need to consider how they can make a living for themselves, rather than hoping that someone else will do it for them. And what better than to combine the need for new livelihoods with the equally pressing need to localise our production of food, water, energy and other essential services? Surely sustainable enterprise is an idea whose time has come?
But if creating a new business is daunting at the best of times, then setting up an enterprise when banks aren't lending, consumers aren't spending and every day, shops seem to be closing – can seem positively terrifying.
So how can we take fear out of the process? Is there a way to enable local people to take the leap and set up their own enterprises with less risk and more chance of success?
At Transition Town Lewes, it's an issue the Enterprise Group has been mulling over for quite a few months. Having canvassed local people in a recent survey, there's evidently no shortage of ideas for enterprises that might support a post-peak oil economy – from a local electric hop-on/hop-off bus to community wood schemes to an aquaponics site. But getting finance, finding customers and simply understanding how to run a business properly are all prevalent concerns, and reasons for not yet taking these ideas further.
What all our would-be enterprisers really seem to need and want is unlimited support.
Setting up an enterprise is often associated with "going it alone" – striking out and forging one's own path. But perhaps enterprise in a REconomy world really needs to be about being in it together. Sharing resources to minimise the financial cost of start-up, sharing knowledge and expertise to reduce the chance of costly mistakes – and sharing awareness so that everyone in a community knows what businesses are starting up and can get behind them to give them the greatest chance of success.
In the Enterprise Group in Transition Town Lewes we are trying to do that in a number of ways.
We've started to invite local people to put forward their skills and resources for an Enterprise Resource Bank, with the aim that resources can be exchanged for free, reciprocally or for payment. We're hoping that alongside traditional professional skills, the Enterprise Resource Bank can be a way for people to share any useful resource, be it storage space, premises, transport or bulk-buy materials.*
We are also starting to get behind individual start-ups such as our one-woman draught-proofing business, SNUG, which is providing draught-proofing demonstrations in local homes. Plus we are looking to team up with other enterprise support networks in the town to see how we can work together to give local people both practical business know-how and more confidence to make that leap from thinking about enterprise to doing it.
We've already seen in Lewes what can happen when a community champions a sustainable business, with the success of our community-owned electricity company Ovesco. We'd like to see other smaller enterprises elicit equal passion and support.
It's about making enterprises sociable, connected and, most of all, truly wanted by the people who are going to use them. Once an enterprise can elicit that kind of support, then being in business starts to look a whole lot less scary – and a lot more like fun.
*And if anyone else in the Transition Network is doing something similar, we'd love to see how we can link up to create a national (or even international?) skills & resource bank.


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DOWNLOAD AGENDAU-BASE CALENDAR U-BASE CALENDAR (iCal)
After opening the link press the 'Plus sign' in the right corner
After months of hard work on a great canoe, the 2017 Concrete Canoe Race is finally here! The CCR committee will race for eternal glory and a small group of other U-BASE members will be there to cheer them up. We will have a great weekend with hopefully a price to bring back to the base!
After-race update:
The day started great with good results in the first heats, but unfortuneately the concrete strength of our canoe proved to be less high than we hoped for. This resulted in a broken canoe. Nevertheless, we had a splendid day, sitting in the lovely sun, watching the races and simply enjoying the great vibe that hung around the race. And we didn't return back home empty handed: we won the award for most sustainable canoe! Awesome!


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Web Scraper to collect and parse out job posting information on our website
Budget $30-250 USD
Dear developers and data miners,
We have a website that host hundreds of jobs from companies and other sources. Most of the time we would have to manually search for job post from other website and manually post them unto our website which is tedious knowing that this task can be automated.
We are therefore looking for someone who can automate this process for us by way of writing some scripts that can automatically scrap job postings from the websites of different recruiting agencies and post them unto our website for users to search and apply to them.
If you think you have the competence to work on this, you can apply and we discuss further details.
Why did you apply to this particular job?
Why do you think you are a good fit for this particular project?
44 Freelancer bieten im Durchschnitt $156 für diesen Job
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Hello client.⭐⭐⭐⭐⭐ I read carefully your proposal. I bid this project because i am sure i can complete this job and all of these skills are my main techs. I am a professional web and full stack developer. * No Upfront Mehr
*** Hello. I have good experience with scraping and posting automatically. I have checked your description and understood. I can do your project well. I want to discuss with you in detail.
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Hello,sir. I have checked your project description. I have 7+years of experience software and database, website. I can implement your project with fully and completely. I can help you with my best. Thanks for your post Mehr
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As a racial-ethnic socialization (RES) scholar, watching dance reality shows has gotten me to think about another dance that goes on (and is often unnoticed) for many parents: working together to teach their child how to navigate a racialized world.
Tag: children's mental health
3 Essential Tips to Help All Kids to Embrace Their Race and Ethnicity
It is important that we talk about race-ethnicity with children – all children. A recent ethnic-racial identity intervention study provided an opportunity for teenagers to explore their culture and develop a clearer sense of what their ethnicity-race meant to them. Participating had positive effects on youth from all racial-ethnic backgrounds.
What is One Simple Thing You Can Do to Prevent Gun Violence at School? Say Something
Say Something Week empowers children to help others and prevent tragedies. They are taught to 'Say Something' to a trusted adult to prevent a friend from harming themselves or others. This programing has the potential to save lives in the communities it reaches. Though it is a daunting task to ensure that no student ever has to go to school in fear, campaigns such as Say Something Week can work with schools and youth programs to maximize their safety, learning, and potential.
Black Pain, Black Joy, and Racist Fear: Supporting Black Children in a Hostile World
When it seems like Black children are mistreated for expressing anger, fear, joy, or for simply existing, it can be a daunting task to figure out how to best protect them from harm while also allowing them to live and thrive unapologetically. Here are a few things to consider from the research.
Beyond the "Melting Pot": Why We Need to Support the Multicultural Identities of All America's Children
When we create an environment that leads children to feel ashamed of their ethnic identity, or to think that they cannot be both ethically identified and American, we are robbing them of a crucial protective factor that enhances their development. Numerous research studies have found that strong ties to cultures of origin, multilingualism, and multicultural identities provide cognitive, academic, social, and emotional advantages.
"But Daddy, Why Was He Shot?": How to Talk to Children about Race Today
This is the first in a series of blog posts that the American Psychological Association (APA) will publish regarding racial/ethnic socialization practices, programs, and approaches. APA is putting together a clearinghouse of resources to help parents/caregivers to protect youth of color and themselves from the psychological damage of discrimination and racism.
Are You Talking to Parents About Keeping Guns Away from Children? 5 Reasons You Absolutely Should
Did you know that 1 in 3 homes with kids has a gun, many unlocked and loaded? June 21 is ASK (Asking Saves Kids) Day – a national observance that reminds health professionals, parents, and caregivers about the importance of asking if there are unlocked guns in the homes where children live and play. Although the conversation may be awkward, having it could potentially save a child's life. Here are five reasons why psychologists should talk to their patients about gun safety.
[CROSS-POST] Put Aside What We Don't Know and Support Justice-Involved Youth with Mental Health Needs
We need to be careful about the language we use to discuss mental health and juvenile justice—and even more careful about how we meet the mental health needs of justice-involved youth.
Think of the Kids: Four Questions with Two Child Psychology Authors
To mark Children's Mental Health Awareness Day (May 4), we posed a series of questions to the authors of two titles from APA's Magination Press, which publishes innovative books that help children deal with the many challenges and problems they face as they grow up.
7 Essential Tips to Help You Master Disciplining Your Kids
Discipline has a significant role to play in what is arguably the world's most important job—raising children to be moral and responsible members of society. And, not surprisingly, there's no shortage of advice about how to do it. Unfortunately, a lot of it is contradictory.


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I read this aloud to my 4 and 8 year olds and they LOVED it. They were very sad when it went back. I would far rather read this style of remade classic than fairy tales. It is a challenge to make it through, but the language is rich and complex without being overwhelming for the speaker.
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Morrissey Engineering has earned our reputation as being the best and most experienced commissioning firm in the Midwest.
We recognize that commissioning is vital to successful building operation. Our comprehensive processes for validating the many systems integrated into today's designs make certain that each building we commission operates properly and efficiently.
We offer a dedicated team to provide both in-house and third party commissioning services. This licensed and credentialed commissioning team, though part of our firm, is an autonomous division that operates independently of any other MEP department.
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26 October 2016
He has been called a charlatan and fantasist – but a new exhibition lends credence to the account Lawrence of Arabia gave of his own extraordinary exploits in the desert.
What emerges according to one expert is the re-rehabilitation of a war hero.
He has been called a charlatan and fantasist – but a new exhibition lends credence to the account Lawrence of Arabia gave of his own extraordinary exploits in the desert.
What emerges according to one expert is the re-rehabilitation of a war hero.
TE Lawrence was a low-ranking British military intelligence officer who played a key role in the Great Arab Revolt (1916-18) against the Turkish Ottoman Empire during the First World War.
Memorably photographed in Arab dress, he was accidentally 'discovered' by an American reporter and became an iconic figure of the 20th century, feted by royalty and immortalised in David Lean's classic 1962 film.
But since then separating the man from the myth has proved impossible, especially after a critical biography was published in the 1950s.
Now his reputation and impact are being reassessed in a UK first exhibition - now open - being hosted by the National Civil War Centre in Newark, Nottinghamshire.
It is based on 10 years' research by archaeologists following in Lawrence's footsteps in the Jordanian desert, armed with Seven Pillars of Wisdom, his own often criticised account of the revolt, fully published in 1935.
"We found field evidence to support Lawrence's claims wherever we looked," said Neil Faulkner, who together with Nick Saunders, both from Bristol University, headed the Great Arab Revolt Project (GARP), drawing on volunteers from across the UK.
"For three years we searched to locate one of the desert camps he used before launching attacks on the Hijaz railway line. There we found spent cartridges and rum bottles discarded by British troops. We also excavated the site of the deadly attack on a Turkish supply train, featured in David Lean's film. The investigation confirmed Lawrence's account in every detail.
Spent bullets and blown up railway line are some of the artefacts being displayed for the first time, together with the chest used by Lawrence to carry gold to pay Arab chiefs and the robes he wore in a 1919 publicity shot that helped propel him to worldwide fame. Neil Faulkner continued:
"Many in the Arab world view Lawrence as a third rate agent of imperialism. He was a very unlikely war hero - an orientalist and archaeologist, as well as a misfit and maverick. But he was a brilliant military commander. Without his help it's unlikely the Arab army would have achieved the success they did in defeating the Ottoman Empire."
The exhibition also focuses on Lawrence the man, his legacy and the aftermath of the Great Arab Revolt. A copy of a map he drew up with polymath Gertrude Bell on how the region should be reshaped for consideration by the British Cabinet, is also on display.
"He was a pro-Arab nationalist and wanted to see a very different future to that carved out by the British and French, which took little note of tribal boundaries and sentiment. The results of that can still be seen today."
Michael Constantine, Manager of the National Civil War Centre, added:
"We're thrilled to work with the GARP team to host this fascinating show. Although we are primarily tell the story of the 17th century clash between King and Parliament, we also step outside our time-period to stage world class exhibitions. Previously we have hosted Magnum Agency photographs of civil wars in the twentieth century in places like Yemen, Somalia and Syria, which links to the aftermath of the Great Arab Revolt. Of course the story of Lawrence is truly spell-binding."
The show runs until 31 March 2017 and is open daily 10am to 4pm. Entry is free with normal admission to the National Civil War Centre: £8 adults, £7 concessions and £3.50 children. A season ticket is just £16 and English Heritage members go half price.