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This Program Announcement expires on January 3, 2004 unless reissued. HIV PATHOGENESIS IN WOMEN'S INTERAGENCY HIV STUDY (WIHS) Release Date: April 26, 2001 PA NUMBER: PA-01-084 National Institute of Allergy and Infectious Diseases (http://www.niaid.nih.gov) National Institute of Child Health and Human Development (http://www.nichd.nih.gov) National Institute on Drug Abuse (http://www.nida.nih.gov) National Institute of Dental and Craniofacial Research (http://www.nidcr.nih.gov) National Institute of Diabetes and Digestive and Kidney Diseases (http://www.niddk.nih.gov) National Institute of Neurological Disorders and Stroke (http://www.ninds.nih.gov) Office of Research on Women's Health (http://www4.od.nih.gov/orwh) National Center for Complementary and Alternative Medicine (http://www.nccam.nih.gov) Application Receipt Dates: May 1, 2001, September 1, 2001, January 2, 2002 THIS PA USES THE "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. IT INCLUDES DETAILED MODIFICATIONS TO STANDARD APPLICATION INSTRUCTIONS THAT MUST BE USED WHEN PREPARING APPLICATIONS IN RESPONSE TO THIS PA. PURPOSE The National Institute of Allergy and Infectious Diseases NIAID), the National Institute of Child Health and Human Development (NICHD), the National Institute on Drug Abuse (NIDA), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute of Neurological Disorders and Stroke (NINDS), the Office of Research on Women's Health (ORWH), and the National Center for Complementary and Alternative Medicine NCCAM), National Institutes of Health (NIH), invite applications for highly focused basic research integrated with the Women's Interagency HIV Study (WIHS) scope and structure. This PA is a renewal of PA-97-105, which was published in the NIH Guide on 09/05/1997. Applications are expected to utilize the WIHS study population, a large cohort of HIV-infected women in the U.S., to formulate specific hypotheses concerning HIV/AIDS pathogenesis in women. The WIHS cohort is followed in five large metropolitan areas (New York, Washington DC, Chicago, Los Angeles and San Francisco). HEALTHY PEOPLE 2010 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS-led national activity for setting priority areas. This Program Announcement (PA), HIV PATHOGENESIS IN WOMEN'S INTERAGENCY HIV STUDY (WIHS), is related to the "HIV" focus area. Potential applicants may obtain a copy of "Healthy People 2010" at http://www.health.gov/healthypeople. ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of state and local governments, and eligible agencies of the Federal government. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as principal investigators. MECHANISM OF SUPPORT This PA will use the National Institutes of Health (NIH) research project grant (R01) award mechanism. Responsibility for the planning, direction, and execution of the proposed project will be solely that of the applicant. The total project period for an application submitted in response to this PA may not exceed four years. Applications submitted in response to Program Announcements are assigned according to established PHS referral guidelines. When the subject of an application is of interest to more than one component of NIH, dual assignments are made. Specific application instructions have been modified to reflect "MODULAR GRANT" and "JUST-IN-TIME" streamlining efforts being examined by the NIH. Complete and detailed instructions and information on Modular Grant applications can be found at https://grants.nih.gov/grants/funding/modular/modular.htm. A notice of modification and update (OD-00-046) regarding modular grants was released on 7/24/00 and can be found at https://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-046.html. RESEARCH OBJECTIVES A. Background 1. HIV IN WOMEN HIV in women is increasing globally. Women constitute over 45% of the approximately 36 million people estimated to be living with AIDS worldwide in 2000 and 47% of the nearly 5 million adults who were newly infected with HIV during the year 2000. In the United States (U.S.), the epidemic began expanding among women in the late 1980s. As of June 2000, the Centers for Disease Control and Prevention (CDC) estimated that the cumulative number of AIDS cases in adults and adolescents women in the U.S. was 124,911 (approximately 17% of all AIDS cases)-— with 10,469 AIDS cases reported in the 12- month period July 1999-June 2000. In the same 12-month period, 6,984 HIV infections were reported among adult and adolescent women. In this group, self-identified exposure categories included heterosexual contact with HIV-infected men (41%), injection drug use (20%), other/risk not reported (38%) and receipt of blood transfusions or blood components (1%). In addition, the impact of HIV/AIDS in the U.S. has been particularly severe in minority populations and, recently, among young people. In the 36 geographic areas with name-based HIV reporting, 78% of new HIV infections in women between July 1999 and June 2000 occurred among African American and Hispanic women. Among men, these minorities represented 59% of new HIV infections. In the same 12-month period, young people aged 13 to 24 accounted for 16% of newly reported AIDS cases, evenly divided between women and men. Since the widespread introduction of highly active antiretroviral therapy, the death rate in persons with AIDS has decreased dramatically nationwide. As a result, among women 25 to 44 years old, AIDS has dropped from the third leading cause of death in 1995 to the fifth leading cause of death in 1998. However, the reduction in AIDS deaths among women has not been as marked as the death reduction among men. At the current stage of the HIV/AIDS epidemic, new paradigms have emerged that are likely to influence the direction of future research on HIV/AIDS. Marked gender differences may exist in HIV disease progression, response to antiretroviral therapy and complications of therapy. Differences in HIV pathogenesis may be the basis for gender specific differences in health outcomes. Women with HIV/AIDS suffer from a variety of conditions unique to women such as human papilloma virus abnormalities, vulvar and vaginal carcinomas and pelvic inflammatory disease. In addition, HIV-infected women have a higher prevalence of recurrent yeast infections, genital ulcer disease, and severe herpes infections than their male counterparts. Studies have demonstrated a wide variety of adverse conditions associated with antiretroviral therapy and these conditions affect many organ systems. Women infected with HIV may develop complications that are different from those in men. Since highly active antiretroviral therapy may extend HIV seropositive women's lives, in depth studies are necessary to investigate the factors and mechanisms underlying the pathogenesis of HIV disease and the pathogenesis of such chronic toxicities. Studies of HIV/AIDS in women can play a unique role in testing new biological or socio-behavioral hypotheses at the population level and in linking basic science findings and laboratory methods to epidemiologically well-defined populations and communities. 2. WIHS The Women's Interagency HIV Study (WIHS), a multicenter, prospective study, was established in 1993 to carry out comprehensive investigations of the impact of HIV infection in women. A total of 2,641 women (2066 HIV positive and 575 negative), 80% of minority background, were enrolled. In addition to NIAID, other NIH institutes currently fund different components of the WIHS. These Institutes include: the National Institute of Child Health and Human Development (NICHD), the National Institute on Drug Abuse (NIDA), the National Institute of Dental and Craniofacial Research (NIDCR), and the National Cancer Institute (NCI). The WIHS has interacted with the community from the outset, by soliciting the community's input to better identify problems and to pursue research opportunities. Community involvement through the individual WIHS sites and the Community Advisory Board (CAB) continues to be encouraged to foster women's participation and understanding of research scope and results. The WIHS was established to investigate the clinical, laboratory and psychosocial aspects of HIV infection in women, in a multi-site, prospective fashion. The WIHS is well positioned to contribute key information on many aspects of HIV infection and disease in women particularly in the era of combination antiretroviral therapy. Such aspects include the history of HIV treatment and its virologic and immunologic characteristics, gender differences in biologic markers of HIV, gynecologic manifestations, and socio-behavioral patterns. During the course of the study, progress in HIV/AIDS research will require flexibility in modifying goals and adjusting the infrastructure to reflect new knowledge and state-of-the-art methodology. Research in the WIHS is able to correspond to changes in HIV/AIDS research partly because clinical care and research activities for WIHS participants are carried out at the same health facilities. This allows for real-time clinical observation and laboratory testing of participants. The rapid implementation of new research protocols will be facilitated by close coordination between investigators proposing studies under this Program Announcement and the WIHS Executive Committee and Working Groups. B. Research Objective and Scope Applicants are invited to propose studies focused on basic mechanisms of HIV infection and disease in women. Applications in response to this Program Announcement may include expansion of ongoing studies and new studies. In addition, studies may involve all WIHS sites or may be limited to defined subsets of the WIHS population, when special requirements exist, such as the need for more frequent participant visits. Studies may address, in detail, biological aspects of HIV infection and how such aspects affect women's health. Proposed studies should emphasize investigations predicated upon specific hypotheses. Applications may focus on investigations in the specific areas of interest of the collaborating NIH Institutes, as outlined below. Important areas of investigation include, but are not limited to, the following subjects: NIAID: grant applications in the areas of molecular basis of HIV infection and disease progression in women in the antiretroviral era, including the interplay of host and viral characteristics; characterization of HIV in cervico-vaginal mucosa and its relationship with HIV in blood; HIV virologic and immunologic factors and their relationship with endocrinologic factors in HIV infected women; characterization of viral reservoirs and their role in HIV-infected, antiretroviral-treated women. NICHD: grant applications in the areas of endocrinologic factors (including both endogenous and common exogenous hormonal exposures), HIV expression, and disease progression; interactions between pregnancy and HIV infection; and fertility-related behaviors among HIV- seropositive women. NIDA: grant applications investigating direct and indirect effects of drug use and associated infectious co- morbidities, such as chronic hepatitis C; metabolic complications such as wasting, lipid and glucose disorders; the impact of drug use, HIV and HIV therapies on peri- and post- menopausal co-morbidities and biological markers; drug-drug interactions and hepatotoxic effects of pharmacotherapies; viral strain variation in association with ongoing drug injection and development of viral resistance to anti-retroviral therapy. NIDCR: grant applications investigating the in vivo role and mechanism of action of oral antiviral factors (salivary and mucosal); the influence of oral co-infections on HIV infection and disease pathogenesis; the role of the oral pharyngeal region as a reservoir of HIV infection; oral diagnostics and therapeutics; the role of host response in candida infections; and characterization of salivary molecules exhibiting anti-candida activities. NIDDK: grant applications to elucidate the pathogenesis of lipodystrophy (lipoatrophy and lipohypertrophy) in HIV patients; studies of abnormalities of insulin sensitivity, glucose homeostasis, lipoproteins, and other components of the "Metabolic Syndrome" or "Syndrome X" in patients with HIV; studies of the AIDS wasting syndrome (AWS), including the effects of HIV on endocrine and gastrointestinal function, metabolism, appetite and diet, physical activity, and body composition; studies of the pathogenesis and natural history of endocrine, gastrointestinal and renal dysfunction in HIV-positive women, including mechanisms of hepatic and renal toxicity. NINDS: grant applications investigating the pathogenesis of central and peripheral nervous system abnormalities caused directly or indirectly by HIV infection in HIV-positive women. Such research could include the role of genetic factors, immune status, and hormonal function in women at risk for AIDS-related neurological disorders. NCCAM: grant applications to investigate the use of complementary and alternative medicine (CAM) therapies among women in the cohort, with attention to comparisons between women using and not using a specific CAM modality. Applications to evaluate the effect of CAM on disease markers, symptoms, progression, and sequelae; the influence of CAM on medication side effects; and clinical outcomes will be considered. ORWH: ORWH will be providing partial funding to selected grants awarded by the Institutes identified above, contingent upon the availability of funds. Grant applications investigating the racial/ethnic differences during early HIV infection and HIV disease progression. Two areas of particular interest are differences in high-risk behaviors (sexual or drug-related) and racial/ethnic differences during early HIV infection and HIV disease progression across a woman's life span. In addition to addressing the aspects described above in the main study population (approximately 2000 HIV seropositive women), focused studies may be conducted in the approximately 500 HIV seronegative women who are currently under active follow-up. These HIV negative women represent a critical control population for research in areas such metabolic changes under highly active antiretroviral therapy and aging. C. Research Structure BIOLOGICAL SPECIMENS Scientific questions addressed by studies submitted under this Program Announcement may utilize biological specimens already collected and banked or specimens to be collected prospectively. Stringent monitoring of specimen utilization will occur throughout the study duration to permit specimen use by a broad number of investigators. Use of WIHS specimens will be restricted to the use stated in the grant. To address any peer-review concerns regarding specimen access, applicants are advised to provide a letter of support with their application from the WIHS Executive Committee demonstrating the establishment of a collaboration with the WIHS investigators. Inquiries on this matter should be directed to the Program staff of the participating NIH Institutes. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their sub-populations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear, compelling rationale, and justification are provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing research involving human subjects should read the UPDATED "NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical Research," published in the NIH Guide for Grants and Contracts on August 2, 2000 (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-048.html); a complete copy of the updated Guidelines are available at: https://grants.nih.gov/grants/funding/women_min/guidelines_update.htm. The revisions relate to NIH-defined Phase III clinical trials and require: a) all applications or proposals and/or protocols to provide a description of plans to conduct analyses, as appropriate, to address differences by sex/gender and/or racial/ethnic groups, including subgroups if applicable; and b) all investigators to report accrual, and to conduct and report analyses, as appropriate, by sex/gender and/or racial/ethnic group differences. NIH POLICY AND GUIDELINES ON THE INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS: It is the policy of NIH that children (i.e., individuals under the age of 21) must be included in all human subjects research, conducted or supported by the NIH, unless there are scientific and ethical reasons not to include them. This policy applies to all initial (Type 1) applications submitted for receipt dates after October 1, 1998. All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines on the Inclusion of Children as Participants in Research Involving Human Subjects" that was published in the NIH Guide for Grants and Contracts, March 6, 1998, and which is available at the following URL address: https://grants.nih.gov/grants/guide/notice-files/not98-024.html. Investigators also may obtain copies of these policies from the program staff listed under INQUIRIES. Program staff may provide additional relevant information concerning the policy. URLS IN NIH GRANT APPLICATIONS OR APPENDICES All applications and proposals for NIH funding must be self-contained within specified page limitations. Unless otherwise specified in an NIH solicitation, internet addresses (URLs) should not be used to provide information necessary to the review because reviewers are under no obligation to view the Internet sites. Reviewers are cautioned that their anonymity may be compromised when they directly access an Internet site. APPLICATION PROCEDURES Applications are to be submitted on the grant application form PHS 398 (rev. 4/98) and will be accepted at the standard application deadlines as indicated in the application kit. Application kits are available at most institutional offices of sponsored research and may be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/710-0267, email: email@example.com. In addition, the application kits can be found on the following URL: https://grants.nih.gov/grants/forms.htm. Applicants planning to submit an investigator-initiated new (type 1), competing continuation (type 2), competing supplement, or any amended/revised version of the preceding grant application types requesting $500,000 or more in direct costs for any year are advised that he or she must contact the Institute or Center (IC) program staff before submitting the application, i.e., as plans for the study are being developed. Furthermore, the application must obtain agreement from the IC staff that the IC will accept the application for consideration for award. Finally, the applicant must identify, in a cover letter sent with the application, the staff member and Institute or Center who agreed to accept assignment of the application. This policy requires an applicant to obtain agreement for acceptance of both any such application and any such subsequent amendment. Refer to the NIH Guide for Grants and Contracts, March 20, 1998 at https://grants.nih.gov/grants/guide/notice-files/not98-030.html SPECIFIC INSTRUCTIONS FOR MODULAR GRANT APPLICATIONS BUDGET INSTRUCTIONS Modular Grant applications will request direct costs in $25,000 modules, up to a total direct cost request of $250,000 per year. (Applications that request more than $250,000 direct costs in any year must follow the traditional PHS 398 application instructions.) The total direct costs must be requested in accordance with the program guidelines and the modifications made to the standard PHS 398 application instructions described below: PHS 398 o FACE PAGE: Items 7a and 7b should be completed, indicating Direct Costs (in $25,000 increments up to a maximum of $250,000) and Total Costs [Modular Total Direct plus Facilities and Administrative(F&A)costs] for the initial budget period Items 8a and 8b should be completed indicating the Direct and Total Costs for the entire proposed period of support. o DETAILED BUDGET FOR THE INITIAL BUDGET PERIOD - Do not complete Form Page 4 of the PHS 398. It is not required and will not be accepted with the application. o BUDGET FOR THE ENTIRE PROPOSED PERIOD OF SUPPORT - Do not complete the categorical budget table on Form Page 5 of the PHS 398. It is not required and will not be accepted with the application. o BUDGET NARRATIVE JUSTIFICATION - Prepare a Modular Grant Budget Narrative page. (See https://grants.nih.gov/grants/funding/modular/modular.htm for sample pages.) At the top of the page, enter the total direct costs requested for each year. This is not a Form page. Under Personnel, provide budget narrative for ALL personnel by position, role and level of effort. This includes consultants and any "to be appointed" positions. No individual salary information should be provided. However, the applicant should use the NIH appropriation language salary cap and the NIH policy for graduate student compensation in developing the budget request. For Consortium/Contractual costs, provide an estimate of total costs (direct plus facilities and administrative) for each year, each rounded to the nearest $1,000. List the individuals/ organizations with whom consortium or contractual arrangements have been made, the percent effort of all personnel, and the role on the project. Indicate whether the collaborating institution is foreign or domestic. The total cost for a consortium/contractual arrangement is included in the overall requested modular direct cost amount. Include a Letter of Commitment or Intent if there is or is to be a subcontract/ consortium. Provide an additional narrative budget justification for any variation in the number of modules requested. o BIOGRAPHICAL SKETCH - The Biographical Sketch provides information used by reviewers in the assessment of each individual's qualifications for a specific role in the proposed project, as well as to evaluate the overall qualifications of the research team. A biographical sketch is required for all key personnel, including consultants, following the instructions below. No more than three pages may be used for each person. A sample biographical sketch may be viewed at: https://grants.nih.gov/grants/funding/modular/modular.htm - Complete the educational block at the top of the form page - List position(s) and any honors - Provide information, including overall goals and responsibilities, on research projects ongoing or completed during the last three years - List selected peer-reviewed publications, with full citations o CHECKLIST - This page should be completed and submitted with the application. Applicant institutions should calculate the Facilities and Administration (F&A) costs using the current negotiated F&A rate, less exclusions, for the initial budget period and all future budget periods. It is not necessary to list the exclusions on the Checklist nor anywhere in the application. If the F&A rate agreement has been established, indicate the type of agreement and the date. All appropriate exclusions must be applied in the calculation of the F&A costs for the initial budget period and all future budget years. o The applicant should provide the name and phone number of the individual to contact concerning fiscal and administrative issues if additional information is necessary following the initial review. The title and number of the program announcement must be typed on line 2 of the face page of the application form and the YES box must be marked. Applications not received as a single package on the receipt date or not conforming to the instructions, including page limitations and font size, contained in PHS 398 Application Kit (rev. 4/98) (as modified in, and superseded by, the special instructions below, for the purposes of this PA), will be judged non-responsive and will be returned to the applicant. Effective for the receipt dates beginning September 1, 2000, applications not in compliance with the modular application instructions will be returned to the applicant institution by the Center for Scientific Review (CSR). Applications revised and resubmitted to NIH in a timely manner may remain in the intended review cycle. (See https://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-046.html) The title and number of the program announcement must be typed on line 2 of the face page of the application form and the YES box must be marked. Submit a signed, typewritten original of the application, including the checklist, and five signed photocopies in one package to: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710 BETHESDA, MD 20892-7710 (Use BETHESDA, MD 20817 for express/courier delivery) REVIEW CONSIDERATIONS Applications will be assigned on the basis of established NIH referral guidelines. Applications will be evaluated for scientific and technical merit by an appropriate scientific review group convened in accordance with the standard NIH peer review procedures. As part of the initial merit review, all applications will receive a written critique and undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of applications under review, will be discussed, assigned a priority score, and receive a second level review by the appropriate national advisory council or board. Review Criteria The goals of NIH-supported research are to advance our understanding of biological systems, improve the control of disease, and enhance health. In the written comments reviewers will be asked to discuss the following aspects of the application in order to judge the likelihood that the proposed research will have a substantial impact on the pursuit of these goals. Each of these criteria will be addressed and considered in assigning the overall score, weighting them as appropriate for each application. Note that the application does not need to be strong in all categories to be judged likely to have major scientific impact and thus deserve a meritorious priority score. For example, an investigator may propose to carry out important work that by its nature is not innovative but is essential to move a field forward. (1) Significance: Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge be advanced? What will be the effect of these studies on the concepts or methods that drive this field? (2) Approach: Are the conceptual framework, design, methods, and analyses adequately developed, well-integrated, and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics? (3) Innovation: Does the project employ novel concepts, approaches or method? Are the aims original and innovative? Does the project challenge existing paradigms or develop new methodologies or technologies? (4) Investigator: Is the investigator appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers (if any)? (5) Environment: Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed experiments take advantage of unique features of the scientific environment or employ useful collaborative arrangements? Is there evidence of institutional support? In addition to the above criteria, in accordance with NIH policy, all applications will be reviewed with respect to the following: o The adequacy of plans to include both genders, minorities and their subgroups, and children as appropriate for the scientific goals of the research. Plans for the recruitment and retention of subjects will be evaluated as well. o The reasonableness of the proposed budget and duration in relation to the proposed research o The adequacy of the proposed protection for humans or the environment, to the extent they may be adversely affected by the project proposed in the application. AWARD CRITERIA Applications will compete for available funds with all other recommended applications. The following will be considered in making funding decisions: Quality of the proposed project as determined by peer review, availability of funds, and program priority. INQUIRIES Inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: NIAID: Paolo Miotti, M.D., M.P.H. Telephone: (301) 496-9176 FAX: (301) 402-3211 E-mail: firstname.lastname@example.com NICHD: Heather Watts, M.D. Telephone: (301) 496-7339 FAX: (301) 496-8678 E-mail: email@example.com NIDA: Henry Francis, M.D. Telephone: (301) 443-2146 FAX: (301) 443-4100 E-mail: firstname.lastname@example.com NIDCR: Maryann Redford, D.D.S., M.P.H. Telephone: (301) 544-5588 FAX: (301) 480-8254 E-mail: firstname.lastname@example.com NIDDK: Barbara Linder, M.D., Ph.D. Telephone: (301) 594-0021 FAX: (301) 480-3503 E-mail: firstname.lastname@example.com NINDS: A.P. Kerza-Kwiatecki, PhD. Telephone: (301) 496-1431 FAX: (301) 402-2060 E-mail: email@example.com NCCAM: Morgan N. Jackson, M.D., M.P.H. Telephone: (301) 402-1278 FAX: (301) 480-3621 E-mail: email@example.com ORWH: Lisa Begg, Dr.P.H. Telephone: (301) 402-1770 FAX: (301) 402-1798 E-mail: email@example.com Direct inquiries regarding fiscal matters to: Ms. Theresa Mercogliano Division of Extramural Activities National Institute of Allergy and Infectious Diseases 6700-B Rockledge Drive, Room 2261 Bethesda, MD 20892 (use Bethesda, MD 20817 for express/courier delivery) Telephone: (301) 402-5512 FAX: (301) 480-3780 E-mail: email@example.com AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.856. Awards are made under authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and administered under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant and contract recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, and portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
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Back to Veterinarians and Staff...
Dr. C. Scanlon Daniels, DVM, MBA was born in central Iowa where his family operated a farrow-to-finish swine operation and a cow calf herd. He graduated from Iowa State University with a Bachelor of Science degree in Animal Science in 1997 and Doctor of Veterinary Medicine in 1998. In 2003, he graduated from the University of Guelph with a Master of Business Administration degree.
After graduation from veterinary school, Dr. Daniels accepted a production veterinarian position with Iowa Select Farms in Iowa Falls, IA where he was responsible for maintaining regulatory compliance, monitoring system health and implementing health improvement processes in a 96,000 sow integrated live hog production system.
In 1999, he accepted a veterinarian position with Seaboard Farms, Inc. During five years at Seaboard Farms in Guymon, OK, he led their Health Assurance Team consisting of seven veterinary, technical and administrative staff. That team was responsible for managing live production health for the third largest pork production company in the US. He was directly responsible for developing the animal health products budget and was a critical member of live production management team and integrated research and development group. During his time there, Dr. Daniels gained extensive experience from numerous PRRSV and Mycoplasma elimination projects.
In April of 2004, Dr. Daniels joined Dr. Angela Daniels in the recently-founded Circle H Animal Health, LLC food animal veterinary practice in Dalhart, TX.
Dr. Daniels currently resides in Dalhart, Texas with his sons Eric, Luke, Judd and Dirk. Dr. Daniels current professional interests are food animal health, food systems production management and food animal research. His involvement in professional associations and publications & presentations are listed below.
Academy of Veterinary Consultants (2004 to Present)
Advisory Board Member, Center for Swine Disease Eradication (2000 to 2004)
American Association of Industrial Veterinarians (2001 to Present)
American Association of Swine Veterinarians (1994 to Present)
American Association of Veterinary Laboratory Diagnosticians (2003 to Present)
American Veterinary Medical Association (1994 to Present)
Dalhart Chamber of Commerce (2004 to 2007)
National Pork Board Veterinary Advisory Group (2003 to Present)
Daniels, C.S., Cowan, T.S. and Sornsen, S.A. 1997. Clinical field study to identify swine respiratory pathogens present in grow-finish pigs and assess their impact on performance. American Association of Swine Practitioners Proceedings, 237-238.
Daniels, C.S., Hoffman, L.J., Apley, M.D., and Schwartz, K.J., 1998. Antimicrobial susceptibility profiles of swine pathogens tested at the Iowa State University Veterinary Diagnostic Laboratory. American Association of Swine Practitioners Proceedings, 59-60.
Daniels, C.S., Daniels, A.M., and Karriker, L. 2003. Challenges in diagnosis and control of swine influenza virus. American Association of Swine Veterinarians Proceedings, 381-386.
Daniels, C.S., Thacker, B., Sornsen, S., and Thacker, E. 1999. Survey of Mycoplasma hyopneumoniae maternally-derived antibodies in suckling pigs. Allen D. Leman Swine Conference Recent Research Reports, 41.
Fitzsimmons, M.A. and Daniels, C.S. 2003. Control in large systems. 2003 PRRS Compendium, 137-142. J. Zimmerman, K.-J. Yoon (eds). National Pork Board, Des Moines, Iowa.
Daniels, C.S. and Fitzsimmons, M.A. 2002. PRRS control in large systems. Trends in Emerging Viral Infections of Swine, A. Morilla, K.-J. Yoon, J. Zimmerman (eds). Iowa State University Press, Ames, Iowa.
Daniels, C. S. 2003. Area spread of PRRSV from a small population of backyard pigs. American Association of Swine Veterinarians pre-conference session, Preventing and controlling PRRSV: mission impossible?
Daniels, C.S. 2003. PRRS control on large farms. The North American Veterinary Conference, 2003 Proceedings, 320.
Daniels, C.S. 2003. Prioritizing time and vet services. The North American Veterinary Conference, 2003 Proceedings, 321.
Daniels, C.S. 2003. Active monitoring of a systems health status. The North American Veterinary Conference, 2003 Proceedings, 318-319.
Daniels, C.S. 2003. The economics of depopulation & repopulation versus herd closure for control of porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae in a multi-site swine production system. Masters project, University of Guelph, Ontario.
Daniels, C.S. 2001. Group-based sow record keeping. American Association of Swine Veterinarians Pre-conference Session: Making your life easier with computer information services.
Baker RB, Yu W, Fuentes M, et al. Prairie dog (Cynomys ludovicianus) is not a host for porcine reproductive and respiratory syndrome virus. J Swine Health Prod 2007;15(1):22-29.

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Mini Muddies Mud Obstacle Race
Friday, 27 November 2015
AELEC, Tamworth, NSW
The Mini Muddies Mud Obstacle Race is a dedicated event for High School students, which will be staged as the Grand Opener for the annual Tamworth-based "Suck it Up Buttercup" Mud Obstacle Race.
This event is for High School Students only, aged 12 to 18 years. When participating in the Mini Muddies you are representing your school and are still under the supervision of attending teachers. Each school is required to bring at least 1 supporting parent per 10 students to volunteer on the day.


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Colca Canyon Bus Tour 2D/1N
19:20pm pick up at your homestay/hotel and transfer to the bus station. Bus departure to Arequipa (10 hours).
06:00am Arrival to Arequipa and transfer to the hotel. FREE TIME IN AREQUIPA.
8:00am pick up from your hotel in Arequipa (2325 m.s.l.). You will take the highway to Yura, first passing through Pampa de Arrieros and Pampa Canahuas where you will see vicuñas, llamas, alpacas, and migratory birds along the way. You will continue to Viscachani where you will enjoy some coca tea to help with the altitude. From here you will continue the trip viewing tokras, ponds, wetlands, and perhaps some flamingos and ibis. Finally, you'll arrive at Patapampa Pass (4900 m.s.l.), the highest point on our journey, and known as the volcano viewpoint. From here you'll see a chain of volcanoes that include Hualcahualca, Sabancalla, and Ampato, the famous volcano where the Inca mummy Juanita (viewable in Arequipa) was sacrificed over 500 years ago. From Patapampa Pass you will descend to the town of Chivay (3646 m.s.l.), the capital of the Colca Canyon region, where you will have lunch and spend the night.
In the afternoon you have the option to visit the Calera Hot Springs for about 2 hours. The thermal bath's medicinal waters reach temperatures of around 40ºC (104ºF) and are wonderful for helping sooth physical ailments.
In the evening you will have dinner (optional) in Chivay with entertainment provided by a traditional folk group.
An early (5:30am) breakfast in the hotel will be had. After breakfast we'll set off for Cruz del Condor (about a 2 hour drive) considered the best viewpoint to truly appreciate the vast expanse of Colca Canyon and also the prime location for condor viewing.
Afterwards, on your journey back to Chivay we'll see archeological sites, pre-Inca farming terraces, and stop at other Colca Canyon lookout points. You'll pass through the towns of Pinchollo, Maca, and Achoma, and then stop in Yanque to see some typical churches, artisan markets, and view the typical dress of the region.
You will have lunch back in Chivay before departing for Arequipa. you'll arrive back in Arequipa around 5:00pm.
Then take an overnight bus to Cusco.
06:30am Arrival in Cusco. Transfer back to your accommodation is not provided.
- Sleeper bus Cusco – Arequipa – Cusco.
- Accommodation in Arequipa for 1 night.
- Accommodation in Chivay for 1 night.
- Meals (1 breakfast, 1 lunch).
- Bus transportation.
- Bilingual Guide.
- Tourist Ticket.
- Buffet in chivay.
Not Included:
- Meals in Arequipa (day 1).
- Water.
- Personal Expenses.
What you Should Bring:
- Passport original or copy.
- Swimming Suit.
- Hiking shoes or boots with ankle support (waterproof recommended).
- Warm Clothes (1 warm sweater or a jacket, long pants).
- 3 t-shirts.
- Shorts.
- Towel.
- Sunglasses and hat.
- Sun Block and insect repellant.
- Extra money for water, snacks, and any other personal expenses or incidentals.
- Positive mind!
- Destinations: Colca Canyon
- Time Needed: 2 Days
- Tour Style: Arequipa
- Distance cover: x
- Intensity: Easy
- Ideal For: Those who like culture and scenery.
- Base Price: $ 175 USD
Photos of our travelers
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NEWS< Back to all posts
My Random Jukebox | The Devils River Interview
My Random Jukebox | Shawn Nelson The Devil's River
I have always talked about how I try to keep an open mind when it comes to my world of music, both on my blog and on social media. Something that has helped me with this goal is talking to musicians about their music as it helps me to appreciate genres that I may not have previously considered. One of these musicians who has helped me with this goal is Shawn Nelson. The way he has talked about his music has made me open my music collection to a sound with a rootsy country feel. It has that honest, and at times heartfelt sound, that I look for in my music. more


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The actress María Eugenia Llamas, "The Tucita", famous for her role in movies with Pedro Infante died Sunday night in the hospital Chapalita in Zapopan, Jalisco, at the age of 70, due to cardiac arrest.
Through a statement reported that the actress had come Saturday to the city of Guadalajara to settle to live with her daughter Maru Lozano Llamas, after living for three years in Tepoztlan, Morelos.
Shortly after her arrival she complained of pains in her spine so he was admitted to Zapopan, where she died at approximately 9:00 pm; the actess is survived by her three children Luzma, Maru and Fernando and three grandchildren.
Llamas rose to fame as a child actress with the Mexican movie star Pedro Infante in movies like Los tres Huastecos y El seminarista.
Born in Mexico City in 1944, after her parents Joseph and Mary Mary Llamas Andresco came to Mexico in 1939 as refugees from the Spanish Civil War.
Her charisma captivated filmmakers like Ismael Rodríguez and Alejandro Galindo, and by adulthood she was sharing credits with Mario Almada brothers Fernando and Humberto Busto and Luis Gerardo Mendez.
After four years, the little actress made her film debut and conquered audiences with her role as Tucita and phrases "Why leave me alone if you already know how I am" and "is a convicted" in the film Los tres Huastecos directed by Ismael Rodriguez and starring Pedro Infante, Blanca Esthela and Sara García Pavón.
Her first performance earned her a nomination for the Ariel Awards, given by the Mexican Academy of Motion Picture Arts and Sciences (AMACC) in the category of Best Children's Performance, and although she did not get the recognition, it was awarded two years later for her performance in Los niños miran al cielo (1950), Robert Rodriguez.
Las dos huerfanitas, Los hijos de la calle, Una calle entre tú y yo, La segunda mujer, Venganza en el circo y La edad de la tentación were some more of her films
In 1966, she married actor and broadcaster Romulo Lozano (1917-1996), with whom he had his children Fernando, María Eugenia and Luz Maria.
It took two decades for her next appearance in film with El gatillo de la muerte (1980), which was followed by Cazador de asesinos (1983), José Luis Urquieta and El criminal (1985), Fernando Duran Rojas, in all of them accompanying the brothers Mario and Fernando Aldama.
Her last appearance on the big screen was under the direction of Jesus Mario Lozano in the film Más allá de mí, in which also appeared Humberto Busto, Flor Payan and Luis Gerardo Mendez.
In Nuevo Leon she was coordinator of the National Institute of Fine Arts (INBA) and played a large teaching to teach courses and workshops in storytelling stage, theater and creativity, and was Director of Culture of the Municipality of Monterrey.
LLAMAS, María Eugenia
Born: 1944, Mexico City, Federal District, Mexico
Died: 8/31/2014, Jalisco, Mexico
María Eugenia Llamas' western – actress:
El gatillo de la muerte – 1985


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2017 Scholarship Winner – Berlin VanNess
2015 Scholarship Winner
Canon City High School senior Bethanny Lyons was awarded the first annual Kent Haruf Memorial Scholarship at a banquet at The Book Haven in Salida on March 19th, 2016 for her story "The Panhandle Blizzard."
Haruf's widow, Cathy Haruf, presented Lyons with her $500 award and a copy of Kent's last novel, Our Souls at Night, after Lyons read her story to the audience. Lyons also was awarded a writing coaching session with Salida writer Susan J. Tweit. "I'm honored to have received this award and very thankful to meet with a published author," Lyons said. Mary Reim, Lyons' teacher at Cañon City High School, was also honored at the banquet.
The Kent Haruf Memorial Scholarship is open to junior and senior high school students in Fremont and Chaffee counties, the two counties Kent called home in Colorado.
Knopf Publishing Announces Posthumous Haruf Novel: Our Souls at Night
Available: May 26, 2015
A spare yet eloquent, bittersweet yet inspiring story of a man and a woman who, in advanced age, come together to wrestle with the events of their lives and their hopes for the imminent future.
In the familiar setting of Holt, Colorado, home to all of Kent Haruf's inimitable fiction, Addie Moore pays an unexpected visit to a neighbor, Louis Waters. Her husband died years ago, as did his wife, and in such a small town they naturally have known of each other for decades; in fact, Addie was quite fond of Louis's wife. His daughter lives hours away in Colorado Springs, her son even farther away in Grand Junction, and Addie and Louis have long been living alone in houses now empty of family, the nights so terribly lonely, especially with no one to talk with.
Their brave adventures—their pleasures and their difficulties—are hugely involving and truly resonant, making Our Souls at Night the perfect final installment to this beloved writer's enduring contribution to American literature.
Will be available in hardcover and ebook formats.
A Lot of Living: Kent Haruf By Claire Kirch
from Publisher's Weekly, Nov 16, 2012
Almost three decades since his first novel, The Tie That Binds, was published, Kent Haruf says the stories that he writes, invariably set on the high plains of eastern Colorado, have become more mythic than factual, intuitive rather than rational. "I haven't lived in eastern Colorado for 35 years," says Haruf, 69, the son of a Methodist minister and a schoolteacher. "I grew up out there. My memory of it is shaped by my experiences decades ago. Memory changes your perspective."
Haruf's fifth novel is Benediction. Like the first four novels, it is set in fictional Holt County and delves, in spare, simple prose that many have compared to Ernest Hemingway's, into the inevitably entwined lives of its rural inhabitants. Haruf considers William Faulkner as the author who perhaps has most influenced him, saying that he likes "to read some Faulkner, Hemingway, or Chekhov before sitting down to write anything."
Benediction is Haruf's first novel in eight years. Eventide, his sequel to the 1999 National Book Award nominee Plainsong, came out in 2004. Those two novels, paeans to small-town life, feature characters from multiple generations whose joys and sorrows intersect with those of the McPheron brothers, two aging bachelor farmers whose lives change after they take in a pregnant, homeless teenager in Plainsong.
In terms of showing their emotions and acting on them, my women characters are a lot more advanced than the men.
-Kent Haruf
Haruf introduces completely different characters in Benediction, with a widow and her daughter at the center of stories of ordinary folks trying to prevail under difficult circumstances: an elderly couple deals with the husband's terminal illness; a young girl moves in with her grandmother after her mother's untimely death; and an opinionated preacher, newly arrived from Denver, alienates his congregation and family, with consequences for his teenage son that are almost tragic.
Benediction started out as a very different book, Haruf says during a weekend visit to Denver, 150 miles north of his home in the small town of Salida, Colo., where he lives with Cathy, his wife of 17 years. "It was a story about a young woman with a young child driving across Colorado; she ended up stranded in Holt," he explains. "The story was going to be about what happens when someone's dependent on the charity of strangers. I got about 100 pages in and then realized I'd already written that story."
Haruf says he then became interested in two minor characters who had appeared in earlier drafts of the book, "an old couple who lived on the edge of town." Says Haruf: "The more I thought about them, the more they became the heart of Benediction."
This is how Haruf conceptualizes all of his creative writing, he says. He muses upon the novel's primary characters, their lives, and how they contend with their problems because "a main character always has to have problems." He then builds communities of people around those characters.
"Once I knew about Dad Lewis and his wife, Mary, then I had to think about what kind of family they'd have, who would be their neighbors, their friends in this little town." Haruf says. "This old man's dying. The people around him, caring for him, and, of course, the kinds of feelings he had as he knew he was dying—those ideas became the heart of the story."
Perhaps this ability of Haruf to adeptly move into the heads of the different characters he creates and weave stories about their lives comes from all the living he's done. After graduating from Nebraska Wesleyan University in 1965, Haruf spent the next two years serving with the Peace Corps in Turkey. Since then, he's worked in rural areas and big cities throughout the Rocky Mountain region and in the Midwest, holding jobs at a chicken ranch, construction site, and railroad, and in hospitals, schools, universities, and an orphanage. He also spent two years at the University of Iowa's Writers' Workshop, receiving an M.F.A. in 1973.
Even though Haruf has set all five of his novels in eastern Colorado, he adamantly rejects the notion that his writings are in any way regional.
"I want to believe there's something universal about these stories," he says. "In some ways, what happens in Holt happens in Denver, in Minneapolis, everywhere. Death is a fact of life, no matter where you live. Taking care of the dying is a necessity everywhere. Those are not conditions exclusive to small towns."


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2018: Lylanne's play, "Frida Kahlo: Heartbreaker" was one of four plays chosen for production at Herstory 3: Journey Women, produced in March by NoPlays in New Haven, CT.
The same play, "Heartbreaker: was also chosen as one of the plays for the 365 Women a Year Play Festival held at FSU in November, and was produced by White Mouse Theatre Productions.
Three of Lylanne's poems from her collection of poems, It's Not Love, Unfortunately, were nominated for the Pushcart Prize.
Lylanne's chapbook, Paparrazzi for the Birds, was selected for publication by Red Mare. It is the 16th collection in the Red Mare series of handmade, limited edition books.
Chatter House Press, published Lylanne's full-length collection of poems, It's Not Love, Unfortunately, in July.
Besides the above mentioned poetry collections, Lylanne had 11 poems accepted in various literary publications, including Free Lit Magazine, Flying Island, Etchings, and Car Poems, among others.
2017: Lylanne's play, "Everything Changes" was one of eight plays chosen for the RCP One Act Festival in Southfield, MI (greater Detroit area). Her play is being directed by Alexander Henderson Trice. The Festival runs from September 7-9th.
2016: The first part two and half months of 2016 was devoted to being Festival Director for 365! Women's Play Festival in Waterford, MI. Lylanne was in charge of finding directors, for the festival, as well as directing two of the 21 that were produced over a four day period in early March.
Two of Lylanne's plays were selected to be produced at the 365! Women's Festival: "Standing Strong in a Field of Color, " directed by Mary L. Pettit, and "Painters in Purgatory, " directed by Karyl Keys Crites.
Lylanne selected two plays to direct at 365! Women's Festival: "Patti Smith, P.I." by Sarah Tuft, and "The Adventures of Etta and Claribel," by Jess Eisenberg.
Poems published in 2016: "Musically Challenged Under 30," and "Frightful (but Delightful) Sight", Flying Island, in January and February.
"Rhubarb Run" was published in the Spring 2016 Issue of Tipton Poetry Journal.
"Unexpected Visitor," "Teddy," "Sickly Fellow," and "Consolations After the Death of My Kitten" as well as a photo of Teddy, and an essay were selected as a "series" to be published in Our Last Walk: Using Poetry for Grieving and Remembering Our Pets, by University Professors Press in Summer 2016.
"Stuck in 'The Office'" is forthcoming at Poetry Breakfast in June 2016.
Weathering Under the Cat, a chapbook with feline themed poems is forthcoming from Finishing Line Press.
"Taxed," and "My Favorite Author" are forthcoming in August and November respectively at Flying Island, 2016.
2015 was a good year for playwriting and directing: Lylanne's play "Frida Kahlo: Heartbreaker" was selected for the Metro Detroit Fringe Festival. She was tapped to direct it as well. "Frida Kahlo: Heartbreaker" won an Audience Choice Award at Metro Detroit Fringe in June 2015. Lylanne also directed "One Cat Away from 61," by Rikki B. Schwartz, at Metro Detroit Fringe Festival.
Her play "Shakespeare at the Hamlet Slam," was performed at Shakespeare in the Parking Lot in Waterford, MI. Lylanne directed.
Lylanne was selected to direct at Boxfest Detroit 2015. She directed the play, "There's Nothing Wrong With Me," by Maureen Paraventi.
Lylanne won a scholarship from Boxfest Detroit 2015. The scholarship was based on directing, as well as a written proposal involving theatre. Lylanne chose to use her scholarship to begin a directing/playwriting group that will select new plays for staged readings, with an ultimate "winning" play selected to be fully produced - and directed with Lylanne's guidance.
2015 in poetry: was one of the participants of The Found Poetry Review's PoMoSco Challenge during April. This challenge will involve the poetry "scouts" completing 30 poetry prompts to attain 30 merit badges. Stay tuned to see if all 30 are achieved! They were! :-)
"Winter Noise" was selected for the collection: The Best of Flying Island. The launch of the book will be at The Gathering of Writers in Indianapolis on March, 21st.
"Weddings" and "Blank Sheet" appear in WCC's Poetry Club 'Zine, Breaking and Mending. She also had her first photography credits in that publication, with four of her photographs appearing in the 'zine as well.
"Breaking News" accepted for Poeming Pigeons, a bird-themed anthology published by The Poetry Box - expected April 2015.
In 2014, Lylanne had 8 poems accepted for publication; in addition, she was one of 67 poets from across the world that completed The Found Poetry Review's Oulipost Challenge - to write a poem a day during April - National Poetry Month, and post each poem on Twitter and on your personal blog. Lylanne was also thrilled to have her poem "Poetry Lets Voicemail Pick Up, 3 AM" published in So it Goes, issue 3 - the literary journal published by The Kurt Vonnegut Memorial Library.
Lylanne had 11 poems accepted for publication in 2013, in addition to the one mentioned below, she also won Honorable Mention at The Toledo Museum of Art's Annual Ekphrastic Poetry Competition, with her poem "Party Stiff." In 2013, she was also fortunate to have her co-authored manuscript, Company of Women: New and Selected Poems, accepted for publication by Chatter House Press.
Check out the Great Writers Steal June 2013 write-up of my poem "The Art of Seeing Value" here, from when that poem was published in New Verse News on June 5, 2013.
Lylanne hosted Writers Speaks Volumes! no-mic readings at Bookmamas in Irvington, Indiana (Indianpolis) the 4th Thursday every month for over three years before moving to Toledo, OH - where she takes part in readings with the Uppity Women Poets.
Lylanne had 16 poems accepted for publication in 2012, and 13 poems in 2011.
Her chapbook, Winged Graffiti, was published by Finishing Line Press in 2011.
Lylanne's poem "Of Critics and Cats" was published in the Summer 2011 issue of Tipton Poetry Journal.
Her poems, "Breaking News," "Life Lessons," and "Consolations after a Bad Date (with Poetry)" were published in the 2011 issue of Ichabod's Sketchbook.
Her poem "A Date With Nature" was published in the 2011 Outrider Press Anthology, A Bird in the Hand.
Lylanne's poem "Perfectionist" was published in the 2010 Outrider Press Anthology, Seasons of Change. "Perfectionist" was the HM winner for poetry.
Her poem "Gesso" was published in the 2010 issue of Ichabod's Sketchbook.
Her poem "Resurrecting Poets in 2010" was published in the Winter 2010 issue of Tipton Poetry Journal.
Lylanne had 3 poems published in 2010, and 11 poems in 2009.
Lylanne participated in the Founder's Day Gathering at Gallery 308 in Muncie, IN on November 6, 2009, with her two poems "Gesso" & "Another Day" that were inspired by the painting "The Fields I Flew In" by Sarah LaBarge.
Lylanne was the featured reader at the TallGrass Writer's Guild open mic held at the Bourgeous Pig Cafe in October 2009 to debut her chapbook A Charm Bracelet for Cruising.
Her poem "The Day Truman Capote Died" was published in the August 2009 issue of PANK Magazine online.
Her poem "Grammar Blues" was published in the September 2009 issue of Umbrella.
Her poems " Cruising, 1975," "Outside the Coffee Shop," & "Some Memories are Better than Others," were published in the October 2009 issue of Wilderness House Literary Review.
Her poem "If You Only Knew" won the Eli Jenkins' Five and Country Senses Competition in Chicago, is September 2009. That poem can be found at Caffeine Theatre.
Lylanne's poem "Seductive State" is in the spring 2009 issue of Tipton Poetry Journal.
Her poems "We Grow 'em Big" and "Manipulation" were published in the inaugural issue of Ichabod's Sketchbook - 2009.
Lylanne won 3rd place & $100 for her poem "A Paparazzi Moment" in the Masterpiece in a Day 2008 competition in Fountain Square - an arts district on the south east side of Indianapolis. Lylanne previously won 2nd place with poems written in the annual 6 hour competition in 2005 & 2006.
Lylanne was published in the Baby Boomer Birthright Anthology - to find out more about this publication or to order a copy of the anthology click here.
Lylanne was one of 36 Indiana published poets that participant in Arts Kalideoscope - A Film, Poetry & Art event in Muncie, Indiana. The poetry reading was held on Saturday, October 4th at the Cornerstone Arts Center. The art and poetry is on exhibit at Gallery 308 in Muncie through the month of October 2008. A glossy catalog of the poetry and art can be ordered by visiting Lulu and entering Art & Poems in the search box.
Lylanne made her directing debut in Canton, MI in January 2015, at the Canton One Acts Festival. The festival is produced by TLC Productions. The play Lylanne directed was "Crisis Line" by Dan Borengasser; Maureen Paraventi was cast as Trish, and Sally Dixon as Sarah.
Sally Dixon, Lylanne Musselman, Maureen Paraventi
Lylanne is an active participant in the 365 Women A Year: A Playwriting Project. So far, she has contributed two short plays: "Frida Kahlo: Heartbreaker" and "Painters in Purgatory" (a play featuring artist Alice Neel).
Lylanne's monologue, "Of Mother and Men" was published in Mother/Daughter Monologues, Volume 2: Thirtysomethings.
Her one-act play, Surfacing, was produced at The Strother Theatre, Ball State University, Muncie, IN. April, 2000.
The above cat portrait is colored pencil on black mat board
The portrait above and to the right are charcoal drawings.
Copyright 2007 Lylanne Musselman. All rights reserved.
Last updated January 2019.


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Where are the major gaps in the reserve network for Africa's mammals? (Cambridge University Press (CUP), 2004-01)The establishment of protected areas for wildlife conservation in Africa was motivated by a number of different reasons (including hunting, recreation and wildlife conservation). The current reserve network provides good ...


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Clarice L. Osborne Memorial Chapel
The Clarice L. Osborne Memorial Chapel was moved stone by stone from the village of Sproxton, England, to serve as the spiritual center of the university. The chapel was dedicated at Baker in 1996 by Lady Margaret Thatcher, former British prime minister, whose father had preached in the building. Today, weekly university worship services are held at 11 a.m. on Thursdays during the academic year. Services are optional, and no classes or meetings are held at that time. The nondenominational services allow students to stay connected with their spiritual life practices and to explore their beliefs during college.
Originally built in 1864, the Sproxton Methodist Chapel served its members for 124 years. Robert R. Osborne, of Olathe, Kan., generously provided the funding to dismantle, ship and rebuild the chapel, which was renamed to honor his wife, Clarice.
Osborne Chapel is open from 7 a.m. to 5:30 p.m. Monday through Friday and by appointment only on the weekends and evenings. Appointments can be set up through the university minister's office by calling 785.594.4553 to arrange for the chapel to be open for your visit. The university minister's office and a fellowship area for students are located in the lower level of the chapel.
Chapel Tours
With prior notification, tours of the Clarice L. Osborne Memorial Chapel are available to visiting groups of 10 or more. Please call 785.594.4553 to inquire about details for your visit.
The Rev. Kevin Hopkins
Minister to the University
A regular participant in music camps on the Baldwin City campus during his youth, the Rev. Kevin Hopkins returned to Baker University in 2014 to serve as Minister to the University. Known as RevKev, Hopkins was the senior pastor at Leavenworth (Kan.) First United Methodist Church from 2009 to 2014.
"I have been affiliated with several private colleges in Kansas, and Baker has always been the school that is highly respected by other regional schools," says Hopkins, originally from Hutchinson, Kan. "For the past several years now, I have felt God calling me to return to campus ministry."
His experience in campus ministry includes stints at Grace United Methodist Church on Southwestern College's campus in Winfield, Kan., and as dean of students and campus pastor at Kansas Wesleyan in Salina, Kan. He previously held faith-based leadership positions at Southern Illinois University in Carbondale, Ill., and Northwestern University in Evanston, Ill.
"I embraced my calling to serve God because of my involvement in campus ministry," he says. "I have always felt called to serve on a campus and give back. I hope I can help students juggle academic and social expectations while at the same time encourage them to grown in their faith."
Hopkins earned an undergraduate degree from the University of Kansas and a Master of Divinity from Garrett-Evangelical Theological Seminary in Evanston, Ill. Hopkins and his wife, Joni, have six children. His interests include running, playing basketball, Ping-Pong and racquetball. For 14 years, he has served as a chaplain with the Kansas Air National Guard.
Weddings at Baker
We are pleased you are considering renting the Clarice L. Osborne Memorial chapel on the Baldwin City campus of Baker University as the site of your wedding. This information will assist you with determining arrangements.
Location Address
Clarice L. Osborne Memorial Chapel
Baker University
515 Sixth Street
Baldwin City, KS 66006
Mailing Address
Clarice L. Osborne Memorial Chapel
Baker University
P.O. Box 65
Baldwin City, KS 66006
The Chapel provides seating for just under 100 people. If your wedding includes more than 100 guests, this facility will not accommodate your wedding.
Contact us at 785.594.4553. Reservations allow one hour on site for the wedding rehearsal and three hours on site for the wedding. This rental fee and agreement does not include honoraria for clergy, musicians or other additional contracted services.
Your reservation will be confirmed and placed on our calendar when we receive the signed reservation form and the $50 (refundable) damage deposit, provided that the chapel is available the day and time of your request. The balance of the rental fee is due one month (four weeks) before your wedding date. Payment should be made by cash, check or money order. Credit cards are not accepted. Send the deposit and the signed request form to Baker University.
Mailing Address
Clarice L. Osborne Memorial Chapel
Baker University
515 Sixth Street
Baldwin City, KS 66006
- Fee for couple with no Baker connection: $400
- Fee for couple with Baker affiliation, e.g., Baker students, alumni, trustees of the university, faculty and staff: $200
- Plus refundable damage deposit (required to confirm reservation): $50
- Total projected cost: no Baker connection: $450
- Total projected cost: Baker affiliates: $250
It is the sole responsibility of the bridal couple to arrange for ordained clergy or other official to perform the service.
Bridal couples are to contact and make all arrangements for accompanists and musicians to perform at your wedding. You may contact the Baker University Department of Music (785.594.8478) to obtain a list of local and student musicians to contact to perform at your wedding. (Student musicians are typically only available throughout the academic school year, early September through early May.)
Furnishings and fixtures are considered permanent and may NOT be moved, removed, borrowed, or taken outside the building for any purpose. These include all the fixtures in the chapel and in the offices in the lower level, e.g., baptismal font, cross, banners, candles, candlesticks, plants, baskets, trash receptacles, chairs, decorations.
To preserve the beauty of the chapel and the furnishings you may NOT use nails, hooks, tacks, screws, masking tape, florist putty, scotch tape or staples in or outside the chapel facility. Rice, birdseed and confetti are not allowed inside the chapel or on the Baker campus. Only drip-less candles are acceptable. Alcoholic beverages are NOT permitted on the Baker campus. Tobacco products in any from are not permitted in the chapel.
The chapel is located on a university campus, so we cannot guarantee that campus events and activities will not cause tourist activity and interference the day of your wedding. However, we can schedule your wedding during the best possible time if you indicate accurate arrival and departure times of your wedding party the day of your wedding. In addition we have many groups that reserve and use the chapel and meeting area in the lower level throughout the week, using the facility during day and evening hours. If additional rehearsal time is necessary for your musicians either they, or you, need to contact the chapel secretary to schedule a time for them when the chapel is available.
Contact us at 785.594.4553 if you have further questions. Notify the office immediately to approve change in plans previously indicated on the reservation form.


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Visa applications can be accepted under 'Urgent/ Emergency' category if applicants make out a case for service within 24 hours irrespective of any holidays/working hours. Explanatory letter explaining the urgency/ emergency must be attached to the application. Urgency has to be justified and will be examined on case to case basis. Service provider is not expected to accept frivolous or routine applications under 'Urgent/Emergency' category where no urgency is established or where applications do not need to be processed out of turn in order to meet the urgency.
Fee: Apart from the normal visa fee, an additional fee of €43 is charged by the Embassy for urgent/emergency visa service. Service Provider is not authorized to charge enhanced service charges for urgent/emergency visa services.
Caution: Applicants are advised to beware of third party visa bureaus/ travel agents who charge a hefty amount from applicants for the urgent service.
Fees once deposited is non-refundable even if visa is not granted or granted on a later date.
Urgent/Emergency visa service is not recommended for certain types of visit, e.g., for regular tourism, employment, research, missionary visit, mountaineering, journalism, etc.
Who can apply: Urgent/Emergency Visa service is meant for Dutch nationals who are ordinarily residing in the Netherlands.
Mode: Application for Urgent/Emergency Visa service has to be submitted in person at the VFS Global service center in The Hague only.
Time taken: Generally, the Embassy grants urgent/ emergency visa on the same day on which application is received at the Embassy. In case of incomplete documentation/requirement for additional documentation or other checks or a need for personal interview of the applicant, the Embassy reserves the right not to grant the visa on an urgent/emergency basis despite payment of fees for such a visa.
All general conditions applicable to the type of visa applied for, will apply to urgent cases also.
Note: For further procedural details, please go to website of service provider www.vfsglobal.com/india/netherlands. In case of any discrepancy between this website and the website of the service provider or any Government of India website, please bring the same to the attention of the Embassy at e-mail: firstname.lastname@example.com.


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Board of Supervisors
Chad Reichard – Chairman – email@example.com
C. Stewart McCleaf – Vice Chairman – firstname.lastname@example.com
Charles Strausbaugh – Supervisor – firstname.lastname@example.com
Elaine Gladhill – Supervisor – email@example.com
Barbara A. McCracken – Supervisor – firstname.lastname@example.com
Jeff Geesaman – Township Manager – email@example.com
Karen Hargrave – Township Secretary & Treasurer – firstname.lastname@example.com
Zachary Mills – Township Solicitor
Martin & Martin – Engineers
The Board of Supervisors is the governing body of Washington Township. Board members are elected officials and are elected to staggered six (6) year terms. Board members combine legislative and executive roles as they both enact the township ordinances and are responsible for the administration of the township government. The supervisors derive their authority from the Pennsylvania Second Class Township Code available for reference on-line.
Regular Supervisor Meetings are held on the first and third Mondays of the month (except when a holiday falls on a Monday – that meeting would normally be held the following Wednesday evening).
Supervisor Workshop Meetings are held the Wednesdays prior to the normal Monday meetings.
All Township Meetings are open to the public and begin at 7:00 p.m. in the Washington Township Municipal Building Meeting room located at 13013 Welty Road, Waynesboro, Pennsylvania, 17268.
If you have business to be placed on the Washington Township Supervisors meeting agendas, you may contact the township staff at the Township Municipal Office, Monday through Friday, 8:00 a.m. to 4:30 p.m. at 717-762-3128. All submitted agenda items must be at the township office no later than 4:00 p.m. on the Friday before the regular business meeting and no later than 4:00 p.m. the Tuesday before the workshop meeting.
Regular business and workshops are both official supervisor meetings. Workshops differ in that they are mostly devoted to in-depth presentations and relevant material review while regular business meetings pay invoices, award bids for both township purchases and sales and approve submitted zoning and subdivision applications. All supervisor meetings start with a Pledge of Allegiance to the United States Flag followed by an open forum for citizen comments from the floor.
Streets / Public Transportation – Stewart McCleaf & Chad Reichard
Police / Drug Task Force – Barb McCracken & Charlie Strausbaugh
WTMA / Utilities – Elaine Gladhill & Barb McCracken
Parks / Train – Charlie Strausbaugh & Barb McCracken
Recycling / Transfer Station – Stewart McCleaf & Elaine Gladhill
Equipment / Technology – Stewart McCleaf & Chad Reichard
Planning & Zoning – Elaine Gladhill & Charlie Strausbaugh
Emergency Management – Elaine Gladhill & Chad Reichard


text: Michael Niedermayer wrote: > Hi > > On Fri, Mar 24, 2006 at 11:39:30PM +0100, Arpi wrote: >> Hi, >> >> While working on mjpeg.c improvement (encoding without chroma subsampling) >> i've found that encode_block() is quite messy (compared to decode_block), >> it assumes 4:2:0 format, and its 'n' parameter is an 0..5 block index. >> Although it should not be handled there, instead at mjpeg_encode_mb(). >> This patch fixes only this. > > patch ok > > [...] Does not compile here : mjpeg.c: In function 'encode_block': mjpeg.c:632: error: 'n' undeclared (first use in this function) mjpeg.c:632: error: (Each undeclared identifier is reported only once mjpeg.c:632: error: for each function it appears in.) mjpeg.c: In function 'mjpeg_decode_com': -- Baptiste COUDURIER GnuPG Key Id: 0x5C1ABAAA SMARTJOG S.A. http://www.smartjog.com Key fingerprint 8D77134D20CC9220201FC5DB0AC9325C5C1ABAAA Phone: +33 1 49966312


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15 Nov 2012
Redoubling Cooperation at Hong Kong Dinner in London
UK Trade Minister Lord Green Says Best Opportunities "Yet to Come"
15 November 2012 – Great Britain and Hong Kong have a historic opportunity to develop bilateral trade, according to Lord Green of Hurstpierpoint in his speech last night at the annual Hong Kong Dinner in London.
"It's true about the UK-Hong Kong relationship: it goes back a long way, it's very broad, it's very deep, but – to use a quotation from President Obama – I do believe the best is yet to come," said Lord Green, the UK Minister of State for Trade & Investment.
"Enormous" Opportunities
"The opportunities are enormous across the scale of British economic activity," he said. "I almost cannot think of a single British company that ought not to be looking at the Hong Kong opportunity. The number of enquiries from British companies looking at Hong Kong is at historically high levels at the moment. This is partly due to the enormously successful Think Asia, Think Hong Kong event," he said, referring to the September 2011 promotion organised by the Hong Kong Trade Development Council (HKTDC).
Celebrating its 29th anniversary under the theme "Redoubling Cooperation," the dinner was hosted by HKTDC Chairman Jack So. Hong Kong Chief Secretary Carrie Lam delivered a keynote address outlining plans for Hong Kong's economic development.
Predicting Prosperity
Prior to the dinner, UK Chancellor of the Exchequer George Osborne addressed guests at a cocktail reception, where he said that the rise of the Asian economies will bring prosperity to millions of people around the world.
"Of course, this will bring challenges for Western economies, as we adjust to shifts in economic growth and power," said Mr Osborne. "But I see globalisation not as a threat, but as an opportunity for the UK. By working together, the East and West can build a more balanced and sustainable global economy, bringing greater prosperity to all our citizens. As two of the world's most open economies, let us in Britain and Hong Kong show how it can be done."
Mr Osborne also said the best illustration of mutually beneficial cooperation could be found in the January launch of the Hong Kong-London Forum, designed to promote cooperation in the development of the international renminbi business.
"As two of the world's leading financial centres, Hong Kong and London are natural partners in this endeavour with London adding new corporate users of the renminbi, new investors and intermediaries, and an extended time zone to Hong Kong's offer," he said. The renminbi Forum first met in May 2012, and a second meeting is set to take place in London next month.
The Hong Kong Dinner in London also welcomed more than 350 business leaders and senior government officials from the UK and Hong Kong.
Guests included Andrew Beeson, Chairman of Schroders plc; Sir David Brewer, Chairman of the China-Britain Business Council; Dr Raymond Ch'ien, Chairman of the MTR Corporation; Lord Clement-Jones of Clapham, London Managing Partner, DLA Piper UK LLP; Minister Counsellor Cong Peiwu, Embassy of the People's Republic of China; Sir Vernon Ellis, Chair, British Council; Lord Howe of Aberavon, President, Great Britain-China Centre; Sir Henry Keswick, Chairman, Jardine Matheson Holdings Ltd; Lady Keswick, Deputy Chairman, Centre for Policy Studies; Lord Paul of Marylebone, Chairman, Caparo Group plc; Lord Powell of Bayswater, Co-Chairman, Asia Task Force; Sir Adrian Swire, Honourary President, John Swire & Sons Ltd; Caroline Wilson, British Consul-General to Hong Kong and Macao; and Lord Wilson of Tillyorn, Honourary President of the Hong Kong Association.
Media Enquiries
Please contact the HKTDC's Corporate Communication Department:
Joe Kainz
Tel: (852) 2584 4216
Email: firstname.lastname@example.com
About the HKTDC
A statutory body established in 1966, the Hong Kong Trade Development Council (HKTDC) is the international marketing arm for Hong Kong-based traders, manufacturers and service providers . With more than 40 global offices, including 11 on the Chinese mainland, the HKTDC promotes Hong Kong as a platform for doing business with China and throughout Asia. The HKTDC also organises trade fairs and business missions to connect companies with opportunities in Hong Kong and on the mainland, while providing information via trade publications, research reports and online. For more information, please visit: www.hktdc.com


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I've been making a lot of pumpkin things for the blog lately…
BUT there are fall foods out there other than Pumpkin Whoopie Pies and Pumpkin Granola.
Braised cabbage is an Oktoberfest delicacy.
Well, I think it is–or Whole Foods Market told me it was.
So I've whipped up some Braised Cabbage with Apples for your fall-vegetable-eating-pleasure.
Braised Cabbage with Apples
Prep time
Cook time
Total time
Author: Allison | Frisky Lemon
Serves: 6
- 1 head of cabbage
- 2 carrots
- 2 small apples (or one large apple)
- 1 medium-sized red onion
- ¼ cup plus 1 Tbsp Kerrygold butter (or ghee)
- ¼ cup water
- Sea salt
- Pepper
- Preheat the oven to 325 F
- Slowly melt your fat of choice and use about 1 Tbsp to grease a large glass baking dish (9x13")
- Slice your cabbage into 8 to 10 wedges and line the bottom of the dish.
- Slice your apple and your onion into wedges and your carrots into coins and place on top of the cabbage.
- Drizzle the veggies with the remaining butter or ghee and your ¼ cup of water.
- Cover with aluminum foil and bake for 1 hr.
- After an hour, flip the cabbage and bake for another hour.
- Remove from the oven, and cool.
- When you're ready to eat the dish, place it back in the oven at 425 for 15 minutes or until browned on top.


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Cervical Cancer
Vulvar Cancer
Learn More
Gynecologic oncology is a specialized field of medicine that focuses on cancers of the female reproductive system, including ovarian cancer, uterine cancer, endometrial cancer, cervical cancer, and vulvar cancer. As specialists, they are generally the most appropriate type of physician to treat these kinds of cancers.
Gynecologic cancer is the fourth most common type of cancer in women, affecting approximately 1 in 20 women. In the United States alone, 82,000 women are diagnosed with gynecologic cancer every year.
OHC is pleased to offer two of the world's best gynecological surgeons. In fact, our very own Dr. Marcia Bowling is noted as being one of the Top 8 gynecological surgeons in the world.


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Today's quiz: What company derives 96 percent of its revenue from advertising, has a video platform that is currently negotiating with the
Up and down its ranks, Google executives will tell you without fail that Google is not a media company, that its organizes and manages content, but stays away from producing it. It's an article of faith at the Internet giant. But it's also beginning to show strain as Google moves into new territory.
In February, Google announced a subscription service called One Pass to enable consumers to buy professionally produced news and information across the Web with a single click. And a great many new-media consuming devices featuring Google software called Honeycomb are about to come into the market, making that information all the more attractive and mobile.
Nowhere has Google's growing media proficiency been more apparent than on
The company is also putting time and effort into expanding deals with the N.B.A. and the National Hockey League, because as everyone — including
There have also been reports that Google has set aside $100 million for incentives for well-known celebrities to program their own "channels" on YouTube to increase the amount of high-profile content on the platform. And the media initiatives are not entirely new:
"There is no doubt in my mind they are becoming a media company," said Mike Vorhaus, the president of the media consulting firm Magid Advisors. "They are providing content to consumers and selling ads against it — sounds like a media company to me."
So what, you might ask. What difference does it make what occupation Google writes down on its driver's license?
For starters, being in the media business means looking at media a little differently. Google has been spending a lot of time and some significant money trying to help traditional media businesses stay in business, in part because Google does not want its search engines to crawl across a wasteland of machine-generated info-spam and amateur content with limited allure.
With that objective in mind, the company has also tweaked its vaunted search algorithm to point toward new, real, trusted content and away from link-bait generic content cranked out by so-called content farms. Even if it is a machine doing the executing, the company's push for one kind of link over another is fundamentally an editorial exercise.
In essence, Google, which has cracked the code on the Web advertising model, has come to realize that if content becomes just a commodity, then advertising will follow suit. "Google depends on the high-quality content created by wonderful Web sites around the world, and we do have a responsibility to encourage a healthy Web ecosystem," the company said, sounding more like the pronouncement of a media executive than a statement from a tech company.
Jonathan Glick, chief executive of Sulia, a media company that filters and publishes real-time content from
"They are moving down a road where they are now thinking of the motivation of people who produce content in addition to the content itself," he said.
When big companies bump into a ceiling in an area they have dominated, they tend to shift into new pursuits that may help their core business. RCA commercialized a spectacular invention called radio, but by the mid-1920s the company realized its new wonder needed great content, so it bought and merged several radio stations to form a media company called
As content bolts across both platforms and technology, doing taxonomy on media and technology companies is more complicated than it used to be.
Other than Apple's
The story of the last decade or so has been a huge shift in value from the media companies, which produced the content, to Silicon Valley, where companies like Google and Netflix came up with newer, more convenient and far less lucrative — at least for the media companies — ways to distribute it.
Before Google gets in too deep, the company may want to compare its valuation over the past decade with that of, say, Time Warner or just about any newspaper company in the country.
"We are in the business of media distribution, but I don't think that we would be very good at media creation," Hal Varian, chief economist at Google, said in a phone call.
"I think it's one thing that we have astutely avoided in the last 12 years," he said, adding, "the media business is a tough business."
Tell me about it.Continue reading the main story


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For the Spice Rub:
1. Combine 2 tablespoons each of cayenne pepper, cumin, dried rosemary. Add a generous pinch of coarse salt. Add 2 tablespoons of coffee granules and brown sugar.
2. Grind together with a mortar and pestle to make a spice rub.
For the Beef Brisket:
1. Place the seasoned brisket in an oven tray. Ensure all sides are sealed with the spice rub.
2. Add a generous amount of olive oil. Add chicken stock. Cover with foil and bake at 140/150°C for 4 to 5 hours.
3. Bring 1 cup barley and 2 1/2 cups of the brisket broth to a boil.
4. Reduce the heat to a simmer; cook, covered, until tender and most of the liquid has been absorbed, 20 to 25 minutes.
6. Let stand 5 minutes. Leave brisket to cool down.
7. Crumble the feta over the cooked lentils. Stir.
8. Gently tear the brisket into shards and pan fry for a few minutes to heat through and crisp a few edges.
9. Plate the brisket, pour over remaining juices and add the lentils. Serve immediately.