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or make 4 interest-free payments of $27.50 AUD fortnightly with More info
If you would like a the back end of your ski a little tighter in rough water we have developed a larger upgrade rudder that can be retro-fitted to all of the current Stealth models. Like the rudders it also features a solid 10 mm stainless steel shaft to improve its robustness, but thanks to its semi elliptical design it gives you a greater blade surface area while the straight edge bottom allows to to still paddle the shallows without bottoming out.
While it is always recommended to exit your ski in the shallows rather than beaching your ski, we understand that this is not always possible so we have left the glass behind on this one, with a heavy duty construction from basalt and Innegra™ protecting a foam core which reduces the overall weight while giving superior strength and stiffness.
The rudder shaft varies in length according to the volume in the rear of the ski model, so please select your ski from the drop down menu to ensure the correct fit.
- Shape: Semi Elliptical
- Core: Foam Core
- Construction Material: Carbon Innegra
- Weight: 285g
- Shaft Diameter: 10mm
- Shaft Length: 16 -18cm (made to order)


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A young teen convicted of a quadruple murder has been freed after spending years behind bars.
"For nine years, Davontae Sanford has been incarcerated for the murder of four people at a Detroit drug house. He was just 14 in September 2007 when police found him in his pajamas near the crime scene, and after two days of interrogations, announced that he had confessed…" [ Read more here ]

subset: commoncrawl


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Borr Drilling Limited (BDRILL) – Purchase of own shares
December 6, 2018
|In News
Borr Drilling Limited (the "Company") has today purchased 200,000 of its own shares at an average price of NOK 24.6651 per share. The share purchase has been carried out in connection with the share repurchase program announced by the Company on 28 August 2018.
After this transaction the Company holds 6,498,572 of its own shares in treasury.
6 December 2018
Hamilton, Bermuda
This information is subject to disclosure requirements pursuant to Sections 4-2 and 5-12 of the Norwegian Securities Trading Act.


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ADRIAN, Mich.--Last week, the Adrian College American Collegiate Hockey Association (ACHA) Division I women's ice hockey program took a break from classes to gladly partake in a community service project.
The Bulldogs and alumna Summer Frey '16 raised money for the local Alzheimer's Association by participating in the Walk To End Alzheimer's at Adrian College.
"It was a wonderful day spent with joining families, loved ones, and friends by participating in the Walk To End Alzheimer's," stated fourth-year Adrian coach Brett Berger. "Throughout the day, the money raised was just under $50,000 and collected for the local Alzheimer's Association. This fundraiser also was about bringing awareness for the Alzheimer's disease.
"It takes a community to make a difference" and the team was very honored to help, he said.


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Samsung ARTIK platform delivers power of IoT
Samsung's end-to-end platform opens the way for companies to create IoT products
Samsung Electronics has introduced its expanded Samsung ARTIK smart Internet of Things (IoT) platform featuring two new module families, ARTIK 0 and ARTIK 7, new device management capabilities in Samsung ARTIK cloud and an expanded partner ecosystem.
According to the vendor, the result is a complete IoT development solution to help companies take their IoT projects from concept to reality in record time.
According to a recent research study by 451 Group, 65% of enterprises are using IoT to optimise their services and product offerings.
With the Samsung ARTIK platform, many of these enterprises now can build IoT solutions to further transform their businesses and enter new markets, the company said.
"IoT is one of Samsung's major strategic areas of focus and growth," said Dr. Byungse So, Executive Vice President and CTO for the Samsung Strategy and Innovation Centre. "By enabling the product-development cycle to flourish, we can help usher in the next generation of IoT innovation. We are paving the way for companies to reimagine how these new devices, apps and services can impact everyday life to address global challenges."
Samsung said businesses struggle to build IoT solutions in-house. They have to grapple with the tasks of building a scalable infrastructure, adding new expertise and managing cumbersome integrations. The Samsung ARTIK Smart IoT end-to-end platform provides companies with all the upfront IoT hardware and software they need, so they can focus on developing disruptive IoT products quickly and simply, the company added.
Internal groups at Samsung are leveraging the Samsung ARTIK platform to build fresh new IoT solutions of their own.
"The Samsung ARTIK platform allowed us to cost-effectively build prototypes of our new solution and quickly get it to market," added Youngsoo Do, senior vice president of Digital Control Group, Samsung Electronics. "With the Samsung ARTIK platform, we also have the ability to connect intelligently to other smart devices, as well as to the cloud, which enables new use cases."
The Samsung ARTIK Smart IoT platform unifies hardware, software, cloud, security and partner ecosystems in a single offering so that enterprises can reduce the time, cost and risk typically associated with the delivery of complex IoT solutions.


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The Rooms Corporation is located in St. John's with Regional Museums in Grand Bank, Grand Falls-Windsor and Northwest River.
The objectives of the corporation are to
(a) collect, preserve, present, exhibit and make available for research the historic artifacts, natural history specimens and archival records that represent and illustrate the significant history, culture and natural heritage of the province;
(b) conduct research with respect to the history, natural history, culture and heritage of the province for the purposes of paragraph (a);
(c) collect and present provincial, national and international contemporary and historic art;
(d) advance and promote the works of contemporary visual artists of the province;
(e) support the development of cultural industries in the province;
(f) strengthen the culture of the province; and
(g) provide and enhance client services and partnerships to promote the cultural collections of the province and to show other national and international collections.
The bylaws of the Corporation provide for eleven (11) Board Members which are appointed by the Lieutenant-Governor in Council on the recommendation of the Independent Appointments Commission.
The 11 member board includes a representative from the Department of Tourism, Culture, Industry and Innovation. All remaining 10 positions are available to the general public including a Chair and Vice-Chair.
The Rooms Corporation's current management team consists of five full-time employees who oversee the year-round operation of The Rooms and seasonal operations of the Regional Museums. There are approximately 42 full-time permanent staff as well as seven seasonal staff to operate the Regional Museums.
In addition to providing school programs and public engagement programs, the operation of The Rooms includes rentals for events, meetings, and conferences.
Those who comprise The Rooms Corporation Board of Directors should collectively possess the following qualifications:
Personal attributes required of Board Members should include:
Members of The Rooms Corporation Board of Directors should be available to meet approximately four times per year. Occasionally decisions of the Board will be requested via email or conference call. Board members may also be expected to spend additional time to review materials and prepare for Board and Committee meetings.
Board terms are for a period of three (3) years and board members continue to hold office until he or she is reappointed or a new member is appointed.


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Web Designer WordpressCompanies in and around the Triangle and Raleigh know that graphic designer Toban Penner of Penner Web Design can provide an effective graphic design for your website to make it look better and search engine-friendly. Toban Penner can meet his clients in Raleigh or anywhere within the Triangle to discuss your web and graphic design needs. Visit his website to find out more. Web Designer Wordpress
We Specialize In:


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"Become a Chinese farmer, that's what you should do", this quote from the ultimate China stock and commodity bull, hedge fund guru, Jim Rogers was much more than just an off the cuff remark.
Jim believes in the future of China so much that he uprooted his family to move there several years ago. He even hired a Chinese nanny to teach his kids Mandarin his belief in the future of China is so strong!
Well, as time goes by, many investors are doubting Roger's wisdom for holding such strong beliefs about the future of China.
Over the last year or so, China has been in the headlines due to slowing growth and currency troubles.
- No. 1 Commodity Stock to Buy in 2020
Hint: It's not silver, platinum or any other precious metal. It's not aluminum, nickel, iron ore or lithium, either.
But without it, we couldn't make airplanes, automobiles, batteries, boats, cosmetics, computers, surgical tools or smartphones.
Yet this metal could soon experience the greatest supply crunch in history … which could launch its price to levels never seen before.
In fact, the U.S. stock market plunge during the first two weeks of 2016 has been blamed squarely on China.
The sharp decline was triggered by weak manufacturing data and a falling yuan. These numbers panicked Chinese investors who dumped stocks resulting in a 7% fall in mainland Chinese stocks, prompting authorities to halt trading early for the day.
The data indicated a slowdown for Chinese manufacturers for the 10th consecutive month, and cemented doubt on China's growth prospects and the effectiveness of Beijing's policies of monetary stimulus to spur growth.
Clearly, the U.S. stock market overreacted to China's issues. Market's always overreact to negative stimulus. Truth is, despite China's slowdown in manufacturing, manufacturing is still growing rapidly. IN addition, the slow decline, has been evident for months. The bearish numbers are no surprise.
This sent waves of panic into the U.S. markets. We firmly believe that China's manufacturing slowdown and the Chinese stock market sell off will only have a short term effect on our stock market.
Remember, even with the economic slowdown, China is still projected to grow at 6.8% this year. Not to mention, the Chinese service sector is thriving. Rather than focus on this, Chinese investors chose to focus on the negative and panic.
Reuters reported, China's annual economic growth is likely to slow to 6.8 percent next year from an expected 6.9 percent this year, the People's Bank of China said in a working paper published on Wednesday.
The world's second-largest economy still faces downward pressure and the impact of fiscal and monetary policies that were rolled out this year will be evident by the first half of 2016, the central bank said in the research report.
"Although downward pressures on growth will persist for a while due to overcapacity, profit deceleration, and rising non-performing loans, we expect that the number of positive factors will gradually increase in 2016," it said.
The Real Problem In China
Despite the Chinese economic issues not being near as dire as the financial media and fear mongers would like you to believe, there is a real problem in the world's second-largest economy.
This problem will only get worse, as the economy grows, if nothing is done about it.
The good news is that we have discovered 2 stocks that are poised to create outsized long-term profits from this vexing issue.
This problem goes far beyond the Chinese economy and it could easily make life on earth very difficult.
If you have not guessed it, I am talking about pollution. Pollution is so bad in China that according to research group Berkeley Earth it kills 4000 people per day! Bloomberg reported:
Air pollution is killing an average of 4,000 people a day in China, according to researchers who cited coal-burning as the likely principal cause.
Deaths related to the main pollutant, tiny particles known as PM2.5s that can trigger heart attacks, strokes, lung cancer and asthma, total 1.6 million a year, or 17 percent of China's mortality level, according to the study by Berkeley Earth, an independent research group funded largely by educational grants. It was published Thursday in the online peer-reviewed journal PLOS One from the Public Library of Science.
Coal is the number one pollutant in China. China obtains around 80 percent of electricity and 70 percent of its total energy from coal, much of it polluting high-sulphur coal.
It is estimated that six million tons of coal is consumed daily to power factories, heat homes and cook meals.
The growing middle class leading to greater car ownership, heavy traffic and low-grade gasoline have led to automobiles being another major factor to the air pollution problem in Chinese cities.
Edward Wong wrote in the New York Times: "In February 2013 Deutsche Bank released an analysts' note saying that China's current economic policies would result in an enormous surge in coal consumption and automobile sales over the next decade. "China's air pollution will become a lot worse from the already unbearable level," the analysts said, calling for drastic policy changes and "a strong government will to overcome the opposition from interest groups." The report estimated that the number of passenger cars in China was on track to hit 400 million by 2030, up from 90 million now.
Beijing just issued its highest smog alert of 2015 in December making this a problem that needs to be solved immediately!
What Is The Solution?
Fortunately, China's State Council created a national plan in 2013 to reduce particulate matter by 15% to 25% through 2017 in key regions.
The government earmarked $275 billion to be allocated to solve this problem.
China is not the only nation with a serious pollution problem. Worldwide the market for air pollution control equipment climbed to $61 billion in 2014. This exploding market is expected to grow to $78.4 billion over the next 3 years.
We have identified two companies that are on the forefront of helping to solve China's pollution problem.
The companies are Donaldson Company (NYSE:DCI) and CLARCOR (NYSE:CLC).
Let's take a closer look at each company.
Donaldson Company is a maker of engine and industrial air filtration products with a solid presence in the Asia Pacific region. In fact, 33% of its 2015 operating income has been from the Asian Pacific region.
The Company serves customers in the industrial and engine markets,
including dust collection, power generation, specialty filtration, compressed air purification, off-road equipment, industrial compressors, heavy trucks and light vehicles. The Company's products are manufactured at 39 plants around the world and through three joint ventures. The Company has two reporting segments: Engine Products and Industrial Products.
Noted analyst Michael Farr stated, The company has dominant market share in many of its end markets, which are very diverse and have attractive long-term secular growth potential. And perhaps most important, well over half of company sales are for high-margin and recurring aftermarket products and services, including replacement filters. Financial performance has been outstanding, including very impressive low-teens annual growth in EPS over the past 20+ years. Finally, the balance sheet is very strong and free cash flow generally approaches net income an annual basis.
We concur completely with Mr. Farr and firmly believe Donaldson will make a great addition to your long term portfolio.
The second company on our list is CLARCOR
It is the most diversified air filtration company on earth. The company boasts two manufacturing plants and a sales office in China. 9.7% of total sales came from China in 2014. This represents $146 million which is a 42% increase from the previous year.
The Key Takeaway:
China is still growing at breakneck speed despite the recent slowdown. This growth has resulted in extreme levels of pollution. Investing in companies like Clarcor and Donaldson that develop and manufacturer filtration devices is a smart long term investment in China's growth.


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Dr. Mei-Ling Chan was born and spent her early years in the tropical island of Penang, Malaysia. At the age of twelve, she made the trek to Canada. She is an alumni of the University of Waterloo, graduating from the faculty of Optometry (including an externship in a tertiary eye care facility in Atlanta) in 2002, and from the faculty of Science (Honours Biochemistry) in 1998. Following a two year stint in the seaside town of Yarmouth, Nova Scotia, she came home to Ontario and started practicing in Barrie. Together with her husband and their children, she now calls Barrie home, and is very excited to have recently opened her new optometry office in town. She is a member of the Ontario and Canadian Association of Optometrists. She has served as a clinical assessor in the Canadian Assessment of Competence in Optometry, which tests the competency of an individual to enter practice in Canada. Dr. Chan has also participated in various questions standard setting workshops. These workshops contribute to the development and maintenance of the competence assessments. Dr. Chan enjoys reading optometry journals and attending conferences (especially those held in tropical locales during our Canadian winters!) to keep abreast of the continually expanding scope of optometry. Optometry is more than just checking prescriptions and dispensing glasses. With a barrage of retailers advertising glasses and contact lenses, we lose sight of what we're trying to achieve: healthy eyes that provide us with good, comfortable, clear vision all our lives. Early detection and intervention is crucial in many eye diseases in order to minimize the damage. This view is clearly supported by the government, who expanded the provincial scope of optometry to include the ability to prescribe therapeutic drugs. Now, in addition to our role in detecting eye diseases, optometrists can also treat or initiate treatments of these diseases. My goal is to provide my patients with the knowledge that will empower them to make good choices regarding the health of their eyes. I look forward to getting started on our partnership. Mei-Ling Chan, OD
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Published at Saturday, July 06th, 2019 - 08:50:33 AM. Bedding. By Valentin Cordonnier.
We think our bedrooms as being cozy and safe, perfect for restful sleep. But in today's world of electronic displays and thin walls, sometimes there are to many distractions to get a good nights rest. Canopy beds solve this problem by adding an additional layer of privacy to your bed.
Since the bed is generally the biggest piece of furniture in a bedroom, your dressing clearly sets the tone for the whole room. Whether you're looking for basic items such as flat or fitted sheets, duvet covers, valances and pillowcases, or extras like cushions and throws, quilts and comforters or drapes and hangings, there is a large choice. Manufacturers offer a wide variety of makes, colors, thread count and patterns and coordinate bedlinens and curtains to make it easy to put a pretty room together.
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Answered by:
How do I resolve compiler error for driver: error : Driver Deployment Task Failed: Driver Install
I'll start by admitting I'm a noob at writing Kernel Mode Software-Only Drivers. With that said:
I'm now getting a compilation error for my driver when I use Visual Studio 2011 to build and deploy the driver to the configured remote box. The error I get is:
error : Driver Deployment Task Failed: Driver Install
When I watch the cmd windows that display on the remote box as VS is attempting to deploy the driver, one output does display the following error:
Executing command line: "C:\DriverTest\DevCon.exe"
Process Exit code: 3
Exit Code does NOT match a valid passing exit code
The system cannot find the path specified.
Failed: Process failed to complete successfully
EndGroup: DriverTestTasks::_RunProcess [Failed]
Non-passing Tests:
DriverTestTask::_RunProcess [Failed]
My question is How can I get more information (Verbose mode?) with respect to what exactly is failing?
Now, I do know what I had change which is causing the error, I just don't know why. What I changed was, in the .INF file I ORIGINALLY had:
---- ORIGINAL ---- (slight change in names to protect client)
%MyDevice.DeviceDesc% = MyDevice_Device, Root\SysInfo
---- ERROR ---- [Manufacturer]
%MyDevice.DeviceDesc% = MyDevice_Device, Root\WdfBasic <<--- Changed per Reference docs to indicate this is a Software-Only Driver
I feel pretty darn confident the above is because I still don't understand that well. i.e. Why can I set the Hardware ID to root\SysInfo - something I made up - and the build and deploy works fine, but can't change it with causing an error? I've tried existing ID's as well as other "fake" names and I get the referenced error. Hence my question on is there a way I can diagnose the issue in more detail.
THANKS in advance for any help!Thursday, March 29, 2012 6:46 PM
Sorry, I forgot to reply to close this specific question at this time. Our approach is pending, based on direct conversations with Microsoft, specifically: support for Kernel Mode / Software-Only driver communications from Metro apps.
Thursday, May 3, 2012 6:40 PM
- Marked as answer by Eric Hanson-MSFTModerator Monday, May 7, 2012 5:47 PM
All replies
Which sample are you starting from? What si the name of your driver? Devcon is a test that runs on your driver after the driver installs. The failure occurred before the error in Devcon.
Best Wishes - EricFriday, March 30, 2012 1:28 AMModerator
This isn't based on an existing sample. All I did was, using KMDF, create a shell driver, add a simple IOCTL command that is filling out a trivial structure containing a single int member. In the driver it is simply setting the member to 999. (i.e. The smallest test I could think of to work out issues with deployment, etc. and easy to prove the driver works in desktop - almost completely "out of the box" via the MS provided KMDF template.)
I named the project SysInfo and it compiled, deployed and tested fine (with the Hardware ID set to root\SysInfo). Now I'm trying to work thru step by step evolution of the driver (such as trying to change the Hardware ID, etc.). I obviously don't understand the Hardware ID relationship vs the MS deployment/verification step of: DriverTestTask::_RunProcess. Again, I'm struggling thru the docs and samples related - which are so far all related to a very specific Hardware ID - whereas I'm trying to work out a driver that is not related to a specific hardware item (hence reason I tried to use Root\WdfBasic per the docs I've seen).Friday, March 30, 2012 1:56 AM
What do you want the software only driver to do?
Best Wishes - EricFriday, March 30, 2012 3:47 AMModerator
Sorry, I forgot to reply to close this specific question at this time. Our approach is pending, based on direct conversations with Microsoft, specifically: support for Kernel Mode / Software-Only driver communications from Metro apps.
Thursday, May 3, 2012 6:40 PM
- Marked as answer by Eric Hanson-MSFTModerator Monday, May 7, 2012 5:47 PM


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Citizen Councils + Assemblies
Concept: Citizen Leaders Council and Citizen Assembly
Transpartisan Community Convening: Create an unofficial, transpartisan Citizen Leaders Council and Citizen Assembly a) that serves as the hub of a community wide, multi-sector network-of networks (i.e. a transpartisan alliance) and b) is capable to generating attractive, out-of-the-box, win-win policy options that 80+ percent of people can say "Yes!" to.
Vision: In midst of crisis the Citizen Leaders Council and the large Citizen Assembly becomes unique, influential community resources that meets the needs of BOTH the general as well as the special interests.
Organizing strategy:
Phase One – Create a 12 to 24 member Citizen Leaders Council representing a microcosm of the community – left, right, center, as well as representation from as many of the 12 sectors as possible. This Council serves as an informal, community wide, neutral convener/organizer. Members are informal or formal leaders with social networks, communities, or constituencies they can outreach to for later phases of organizing. Goal at this phase: build trust, respect, and communication.
Phase Two – Organize a day long community wide forum. Each Citizen Leaders Council member outreaches to their network.
- Morning: Transpartisan 101 skill building
- Afternoon: Open space dialogue – "What are the community challenges that most need a transpartisan response?" Creation of topic area "task groups" that will each "work/play" on creating a transpartisan agenda on how to best address leading challenges in a win-win.
Phase Three – Organize a community-wide Citizens Assembly where task groups representing the 12 sectors of the wheel are brought together to cross pollinate and emerge a citizen generated, community wide, transpartisan agenda capable of offering win-win policy options to the community (will educated the community…will NOT LOBBY government.) Transpartisan agenda may be turned into a candidate pledge at election time.
Phase Four – Repeat the process at neighborhood/district level.
Phase Five – Connect with other transpartisan groups nationally, repeat the process on national level beginning with the Second American Citizens Summit, February 2011.


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My overarching career goal is to improve outcomes for children who are deaf or hard of hearing. This work involves families and providers, and interacts with many systems of care. As the director of the Colorado Home Intervention Program (CHIP) for many years, I was in a position to influence the quality of services for infants and toddlers in one state.
Since leaving that position in 2010, I have expanded my reach to enhance systems across the United States, as well as in other countries. This has been done primarily in the higher education world, lecturing and working with local universities in both an academic and research setting.
My intent remains the same: to support individualized assessments and treatments, to promote evidence-based practices, to measure the effectiveness of services, and to improve access to quality services via telehealth. See each tab below for further details on my involvement in these various capacities.
Professional Roles
In addition to my education credentials (BA, Elementary Education, The American University, Washington, DC; graduate coursework in Education of the Hearing-Impaired, Gallaudet University, Washington, DC and University of Northern Colorado, Greeley, CO; MA, Speech/Language Pathology, University of Denver; PhD, University of Northern Colorado), I hold an adjunct faculty position in the Department of Education and Counseling Psychology and Special Education at the University of British Columbia. I also lecture in the Department of Special Education at the University of Northern Colorado. I have been an Instructor in the Department of Speech, Language, and Hearing Sciences at the University of Colorado Boulder, as well as a Clinical Instructor in the Department of Otolaryngology at the University of Colorado Health School of Medicine in Denver, Colorado.
I also hold the Certificate of Clinical Competence in Speech/Language Pathology and have endorsement as a teacher of the deaf and hard of hearing issued by the Colorado Department of Education. I served as a teacher of the deaf and hard of hearing in an urban school district for many years.
For almost 20 years, I served as the Director of Early Intervention and Education Programs at the Colorado School for the Deaf and the Blind (CSDB), directing the Colorado Home Intervention Program (CHIP) and providing technical assistance to early intervention and preschool programs serving deaf and hard of hearing children statewide.
- Co-Investigator, Effectiveness of Therapy via Telemedicine following Cochlear Implants, National Institutes of Health (1 U01 DC013529-01), University of Colorado, Denver, CO, September, 2013 – present
- Principal Investigator, TeleCITE: Telehealth for Cochlear Implant Therapy Exchange; Colorado Clinical & Translational Sciences Institute (National Institutes of Health) 2010 – 2011
- Principal Investigator, Maternal and Child Health Grant for Universal Newborn Hearing; University of Colorado, Boulder, CO 2000-2008
- Deaf/Hard of Hearing Adult Role Model Program; Colorado Department of Education 1997-2007
- Colorado Individual Performance Profile-Preschool Level (Pre-CIPP); Colorado Department of Education 1991-2007
- Services to Deafblind Children Birth-5 years; Colorado Department of Education 1991-2007
- Expanding Services to Spanish-Speaking Families; Colorado Commission for the Deaf/Hard of Hearing, Colorado School for the Deaf and the Blind 2005-2007
- Parent-Centered Services to Later-Identified Children with Hearing Loss; Colorado Department of Education 1998-1999, 2002-2003.
- Case Management for Children with Low Incidence Disabilities; Department of Epidemiology, Colorado Department of Public Health & Environment 1999-2002
- Family-focused Intervention and FAMILY Assessment; Part H Grant, Colorado Department of Education 1989
- FAMILY Assessment for Deafblind Children; Colorado Department of Education 1988-1989


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The Five Reasons Tourists Love Different Ferrari Types | different ferrari types
More about the 2018 Ferrari Portofino
Image Source: motortrend.com
The 2018 Ferrari Portofino is offered in the afterward submodels: Portofino Convertible. Accessible styles accommodate 2dr Convertible (3.9L 8cyl Turbo 7AM).
Customer ratings and reviews are additionally accessible for the 2018 Ferrari Portofino and all its trim types. 0 Edmunds customer reviews acquiesce users to analyze through aggregated customer reviews to accept what added drivers are adage about any agent in our database. Detailed appraisement breakdowns (including performance, comfort, value, interior, exoteric design, body quality, and reliability) are accessible as able-bodied to accommodate shoppers with a absolute compassionate of why barter like the 2018 Portofino.
Edmunds experts accept aggregate a able-bodied alternation of ratings and reviews for the 2018 Ferrari Portofino and all archetypal years in our database. Our affluent agreeable includes able reviews and recommendations for the 2018 Portofino featuring abysmal dives into trim levels and features, performance, mpg, safety, interior, and driving. Edmunds additionally offers able ratings, alley analysis and achievement data, abiding alley tests, first-drive reviews, video reviews and more.
This analysis was accounting by a affiliate of Edmunds' beat aggregation of able car reviewers. Our aggregation drives every car you can buy. We put the cartage through accurate testing, evaluating how they drive and comparing them in detail to their competitors.
We're additionally approved bodies like you, so we pay absorption to all the altered means bodies use their cars every day. We appetite to apperceive if there's abundant allowance for our families and our weekend accessory and whether or not our admired alcohol fits in the cupholder. Our editors appetite to advice you accomplish the best accommodation on a car that fits your life.
Shop Edmunds' car, SUV, and barter listings of over 6 actor cartage to acquisition a bargain new, used, or certified pre-owned (CPO) 2018 Ferrari Portofino for auction near. Simply analysis the blazon of car you're absorbed in and again baddest a car from our massive database to acquisition bargain cartage for auction abreast you. Once you accept articular a acclimated agent you're absorbed in, analysis the Carfax and Autocheck agent history reports, apprehend banker reviews, and acquisition out what added owners paid for the 2018 Ferrari Portofino.
Find a new Ferrari Portofino for auction – 8 abundant deals out of 12 listings starting at $21,530.
Find a new Ferrari for auction – 3 abundant deals out of 21 listings starting at $23,866.
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Is it bigger to charter or buy a car? Ask best bodies and they'll apparently acquaint you that car affairs is the way to go. And from a banking perspective, it's true, provided you're accommodating to accomplish college account payments, pay off the accommodation in abounding and accumulate the car for a few years. Leasing, on the added hand, can be a beneath big-ticket advantage on a month-to-month basis. It's additionally acceptable if you're addition who brand to drive a new car every three years or so.
Check out Ferrari charter specials
The Five Reasons Tourists Love Different Ferrari Types | different ferrari types – different ferrari types
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Oxidative Medicine and Cellular Longevity
Volume 2013, Article ID 507407, 8 pages
Protective Effects of Extracts from Fructus rhodomyrti against Oxidative DNA Damage In Vitro and In Vivo
1Key Laboratory of Molecular Biology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China
2Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA 26060, USA
Received 26 June 2013; Revised 8 August 2013; Accepted 8 August 2013
Academic Editor: Tullia Maraldi
Copyright © 2013 Yuebin Ke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective. To evaluate the potential protective effects of extracts from Fructus rhodomyrti (FR) against oxidative DNA damage using a cellular system and the antioxidant ability on potassium bromate- (KBrO3-) mediated oxidative stress in rats. Methods. The effects of FR on DNA damage induced by hydrogen peroxide (H2O2) were evaluated by comet assay in primary spleen lymphocytes cultures. The effects of FR on the activities of SOD, CAT, and GPx and the levels of GSH, hydroperoxides, and 8-OHdG were determined in the plasma and tissues of rats treated with KBrO3. Results. FR was shown to effectively protect against DNA damage induced by H2O2 in vitro, and the maximum protective effect was observed when FR was diluted 20 times. Endogenous antioxidant status, namely, the activities of SOD, CAT, and GPx and the levels of GSH were significantly decreased in the plasma, the liver, and the kidney of the KBrO3-treated rats, while the pretreatment of FR prevented the decreases of these parameters. In addition, the pretreatment of FR was also able to prevent KBrO3-induced increases in the levels of hydroperoxides and 8-OHdG in the plasma, the liver, and the kidney in rats. Conclusions. Our findings suggested that FR might act as a chemopreventive agent with antioxidant properties offering effective protection against oxidative DNA damage in a concentration-dependent manner in vitro and in vivo.
1. Introduction
Plants have played significant roles in maintaining human health and improving the quality of human life for thousands of years [1, 2]. Fructus rhodomyrti (FR) is the fruit of the Rhodomyrtus tomentosa growing on knolls in wilderness and widely distributed in Guangdong, Guangxi, Yunnan, Fujian, and Taiwan. FR has been used for the production of drinks and wine. FR is a traditional Chinese medicine material with antihepatitis property [3].
Cells that live in an oxygen-rich environment are inundated with various endogenous and exogenous sources of reactive oxygen species (ROS) [4]. The most important target for ROS in the carcinogenesis process is DNA [5, 6]. Irreparable DNA damage is involved in carcinogenesis, aging, and other degenerative diseases [4, 7]. However, enzymatic and nonenzymatic systems, which preserve the oxidant/antioxidant status, are disrupted during oxidative stress, a metabolic derangement due to an imbalance caused by excessive generation of ROS or a diminished capacity of the antioxidant defense system. Dietary factors and natural antioxidants that reduce the impact of ROS can protect DNA damage and thus reduce the risk of cancers [8, 9].
Hydrogen peroxide (H2O2) and potassium bromate (KBrO3) are commonly used to induce oxidative damage [10–12]. KBrO3 is a widely used food additive, a water disinfection by-product, and a known nephrotoxic agent. Cellular proliferation was enhanced in the kidney due to oxidative stress generated by KBrO3. It has also been reported that KBrO3 increased the levels of 8-hydroxydeoxyguanosine (8-OHdG), an oxidative DNA adduct, suggesting that it can indirectly induce DNA modifications by oxygen radicals that are involved in carcinogenesis [9, 13].
In a previous study, FR has been confirmed abundant in flavonoid glycosides and phenols, and the flavonoids extracts of FR displayed an antiradical action and antioxidant effects in serum of rats [3]. However, the biological effects of FR remained poorly understood so far. It is unclear whether or not FR has any protective effects against oxidative DNA damage and antioxidant effects in target organs induced by xenobiotics. In the present study, the potential protective effects of extracts from FR against oxidative DNA damage in vitro and oxidative stress induced by KBrO3 in vivo were explored.
2. Materials and Methods
2.1. Materials and Equipments
Low melting point agarose, Triton-X100, and sodium lauroylsarcosine were purchased from Sigma Company (USA). The normal melting point agarose (NMPA), RPMI1640 medium, and Tris were purchased from Promega Company. Neonatal calf serum was purchased from Beijing Bangding Company, and H2O2 (analytically pure) was purchased from the National Institute for the Control of Pharmaceutical and Biological Products. The antibody against 8-OHdG and 8-OHdG enzyme-linked immunosorbent assay (ELISA) kits was purchased from JaICA (Japan). The confocal laser scanning microscope was purchased from Leica (Germany), and PAC200 transfer electrophoresis instrument was the product of BIO-RAD Company (USA). VE-186 transfer electrophoresis tank was purchased from Shanghai Jinpeng Analytical Instrument Company.
2.2. Preparation of FR Extract
FR originated in Shaoguan, Guangdong, was provided by Traditional Chinese Medicine University of Guangzhou. One kilogram of FR was ground and extracted with 2 L of distilled water at 4°C. After 24 h, the extracts were centrifuged at 15,000 ×g three times. The freeze dry sample was reextracted with 1 L of distilled water. The reextracted sample was extracted with 100% ethanol (1 : 4, v/v), and then the ethanol-insoluble fraction was collected and freeze-dried. The dried fraction was extracted with distilled water for further experiments. Stock solution (1 g/mL) was prepared with phosphate buffer solution (PBS) before use, boiled for 30 min, and then kept at 4°C. Appropriate concentrations were adjusted before use. The experimental concentration was 1 g/mL. Saline (0.85% NaCl) was used as a control.
2.3. Animals
Male albino rats (130–150 g) of Wistar strain were obtained from the Medical Experimental Animal Center of Sun Yat-Sen University, Guangzhou, China. The rats were housed in polypropylene cages in groups of six rats per cage in a room maintaining of 25 ± 2°C and a relative humidity of 40–70% with a 12 h light/dark cycle. The rats were allowed acclimatizing for one week before the experiments and had free access to standard laboratory feed and water ad libitum. The rats were sacrificed according to the guidelines of the current laws of Ethical Committee for the purpose of control and supervision of experiments on animals in China.
2.4. Culture of Spleen Lymphocytes
Sterile isolation of the intact spleen was immersed in PBS solution at 37°C. The spleen capsule and fat composition were removed. One mm3 of spleen tissue was cut off, digested in pancreatin (1-2 min), and then placed in the metal filter net with PBS (pore size of 200 meshes). The spleen was triturated with disposable syringe needle so that the cells can be filtered out from the metal filters. The cell suspension was centrifuged at 1000 r/min (centrifugal radius 10 cm) for 3–5 min, and the supernatant was removed. The cells were suspended in the RPMI 1640 medium containing 10% fetal calf serum. Trypan blue staining indicated that the viable cell count was over 95%. The spleen cells density was adjusted to 5 × 106–107/mL, and the cells were incubated at 37°C in 5% CO2 incubator.
2.5. DNA Damage Assay
Primary spleen lymphocyte cells were cultured for 24 h and centrifuged for 3–5 min (1000 r/min centrifugal radius 10 cm). The cells were resuspended in the RPMI 1640 medium with no fetal calf serum. Trypan blue staining shows that the viable cell count was over 95%, and cell density was adjusted to 5 × 106/mL. One ml of spleen cell suspension was added into each of 12 sterilization centrifuge tubes, which were randomly divided into 4 groups of 3 tubes. Twenty-five μL H2O2 solution of different concentrations (25, 50, and 125 μmol/L) was added into tubes of the 3 H2O2 groups, and equal volume of PBS was added into the blank control group and all tubes were incubated at 4°C for 20 min. Then, single-cell gel electrophoresis (SCGE) was performed.
2.6. Assay for FR Pretreatment In Vitro
A density of 1 × 107/mL of primary cells was prepared. One mL of lymphocyte suspension was added into each of the 18 centrifuged tubes, which were randomly divided into control group, H2O2 treatment group, and the FR treatment groups I, II, III, and IV, with 3 tubes in each group. The cells in the FR groups received the treatment of different concentrations of FR extracts (1 mL) and incubated at 37°C in 5% CO2 for 60 min, followed by the treatment of 25 μL H2O2 solution (50 μmol/L) at 4°C for 20 min, while the cells in the H2O2 treatment group only received the treatment of 25 μL H2O2 solution. The control group cells received PBS treatment. After the treatment, the cells were harvested for SCGE.
2.7. Single-Cell Gel Electrophoresis
Improved methods were used in the study such as Singh, cell preparation in alkaline conditions, alkali treatment, electrophoresis, neutralization, EB staining, reviewing, and analyzing. A laser confocal microscope was used to analyze the morphology of the cells at a wavelength of 488 nm ( times magnification). One hundred randomly selected cells were used to calculate the DNA migration rate (tailing rate), and the total length (maximum length of the direction of comet) was considered as the tail length.
2.8. Animal Treatments
Different groups of animals were used to explore the effects of FR on KBrO3-induced oxidative stress and 8-OHdG induction in the renal tissue of rats. Thirty male Wistar rats were randomly divided into 5 groups (6 rats in each group). Group I received saline injection intraperitoneally (0.85% NaCl) at a dose of 10 mL/kg body weight. Group II received a single intraperitoneal injection of KBrO3 at a dose of 125 mg/kg body weight. Group III received pretreatment with FR by gavage once a day for 5 days at a dose of 150 mg/kg body weight, and groups IV and V received the pretreatment with FR by gavage once a day for 5 days at a dose of 300 mg/kg body weight. After the last treatment with FR, the rats of groups II, III, and IV received a single intraperitoneal injection of KBrO3 at a dose level of 125 mg/kg body weight. Twenty-four hours later, the rats were sacrificed by cervical dislocation.
Blood samples were collected in heparinised tubes, and the plasma was separated by centrifugation at 2000 ×g for 10 min. The tissues (liver and kidney) were isolated and immediately transferred to ice-cold containers containing 0.9% sodium chloride for various analyses. A known amount of tissue was weighed and homogenized in appropriate buffer for the evaluation of various biochemical parameters.
2.9. Biochemical Assays
The antioxidant status was evaluated by measuring the levels of reduced glutathione (GSH) by Khan's method [14] with minor modifications. The activities of glutathione peroxidase (GPx) and SOD were measured as described by Rotruck et al. [15] and Chen et al. [16], respectively. The content of H2O2 was assayed by the H2O2-mediated horseradish peroxidase-dependent oxidation of phenol red by the method of Pick and Keisari [17]. The activity of catalase (CAT) was measured by the method as described by Sinha [18] with minor modifications. The levels of 8-OHdG in plasma and tissues were measured according to the instruction provided in the assay kit for 8-OHdG.
2.10. Statistical Analysis
Statistical analysis was performed using SPSS15.0. One-way ANOVA and test (Student-Newman-Keuls) were used to compare the means among the groups with measurement data after homogeneity testing for homogeneity of variance, and we analyzed enumeration data with chi-square statistics. The level of significance was set at .
3. Results
The results of the effects of different concentrations of H2O2 on DNA damage in vitro were summarized in Table 1. After treatment with 25 μmol/L H2O2 for 20 min, the number of comet tail cells (88%) was significantly increased as compared with the result (15%) of the control group. When the concentration of H2O2 reached 50 and 125 μmol/L, the numbers of comet cells were 100%. The comet tail length indicated the severity of DNA damage. The tail lengths of comet cells treated with H2O2 were significantly longer than those of the control cells (Table 1).
The effects of pretreatment of lymphocytes with FR were shown in Table 2. The data showed that FR of various concentrations could significantly reduce DNA damage induced by H2O2 in spleen lymphocytes. The protective effects of FR were significantly increased with increased FR concentrations from 20 to 80 dilution fold as compared with the positive control group , and the maximum protective effect was observed when FR was diluted 20 times. However, when the concentration of FR was 10 dilution folds, the results of comet cell tailing rate and total comet length were significantly increased as compared with the positive control group (Figure 1, Table 2).
The effects of FR on KBrO3-mediated oxidative stress and antioxidant ability in rats were shown in Tables 3, 4, 5, 6, 7, and 8. The treatment of KBrO3 alone significantly reduced the activities of SOD, CAT, and GPx and the levels of GSH compared with those of the saline-treated control group, and the pretreatment of FR at 150 mg/kg body weight and 300 mg/kg body weight partially recovered the activities of SOD, CAT, and GPx and the levels of GSH in a concentration-dependent manner. However, treatment of FR alone did not produce any effects on the activities of the antioxidant enzymes.
The levels of hydroperoxides and 8-OHdG were significantly elevated in plasma and tissues of the rats treated with KBrO3 as compared with the control rats. Pretreatment of FR significantly decreased the levels of hydroperoxides as compared with KBrO3-treated rats.
4. Discussion
This study demonstrated that FR protected against oxidative DNA damage and to varying degrees reversed the damages caused by oxidative stress via its antioxidant activities. These findings support the hypothesis that FR exerted a protective effect in vivo as well as in vitro.
We evaluated the protective effects of FR against oxidative DNA damage by H2O2 with spleen lymphocytes being based on the following considerations. Firstly, oxidative DNA damage is closely related to aging, and immune senescence plays an important role in aging. During the process of aging, there will be varying degrees of degradation in the immune organs such as spleen and thymus, so it is of great significance to protect the immune cells to avoid oxidative DNA damage caused by chemicals [19]. Secondly, spleen is the largest immune organ in the body, and the cell model is easy to build. Thirdly, spleen lymphocyte models are widely used in experiment to study the protective effects of traditional Chinese medicines.
FR has been reported to contain flavonoid glycosides, phenols, amino acids, organic acids, and carbohydrates [3]. The major antioxidant active constituents of FR are flavonoid glycosides and phenols, which display free radical-scavenging activity and antioxidant properties [20–22]. The observed chemopreventive activity of FR in this study suggested that the protective effects of FR may be attributed to the action of these compounds in FR [23, 24].
In evaluating the effects of FR on lymphocyte DNA damage induced by H2O2, we have tried different dilutions of FR and found 10 times dilution working in a different way as compared with 20 times dilution. The difference between their values was statistically significant in terms of the number of comet cells but not statistically significant in terms of the distance of comet tail (Table 2). This is indeed a very interesting phenomenon and might provide evidence to the double-edged sword theory of antioxidants and reductive stress.
Antioxidants may promote oxidation at high concentrations. Skibola CF and Smith MT have found the potentially toxic effects of excessive flavonoid intake. At high doses, flavonoids may act as mutagens, prooxidants that generate free radicals, and as inhibitors of key enzymes involved in hormone metabolism. Thus, at high doses, the adverse effects of flavonoids may outweigh their beneficial ones. The unborn fetus may be especially at risk, since flavonoids readily cross the placenta [25, 26].
Redox imbalance in cells can lead either to oxidative or to reductive stress. Oxidative stress has been extensively studied for many years, and its possible clinical ramifications have been explored in considerable depth. Reductive stress, by contrast, has not been widely recognised. Yet reductive stress is probably both common and of clinical importance: indeed, reductive stress plus oxygen rather than oxidative stress may be the most common mechanism leading to the generation of reactive oxygen species (ROS). One possible link between the two may be the reduction of Fe3+ and its liberation from ferritin. The reduced metal could catalyse ROS generation [27].
Our results also showed decreased activities of enzymatic antioxidants SOD, CAT and GPx, and the levels of non-enzymatic antioxidant GSH in circulation, liver and kidney of KBrO3-treated rats. ROS generated in tissues are normally scavenged by enzymatic and non-enzymatic antioxidants [28, 29]. Antioxidant defense system protects the aerobic organism from the deleterious effects of reactive oxygen metabolites [30].
Glutathione is a crucial component of the antioxidant defense mechanism and it functions as a direct reactive free radical scavenger [31, 32]. The liver is the major organ with the highest content of GSH, which is transferred to kidney by distinct GSH transport system [33, 34]. The decreased levels of GSH in circulation and tissues in KBrO3-treated rats may due to enhanced utilization during detoxification of KBrO3. GPx and CAT, which act as preventive antioxidants and SOD, a chain-breaking antioxidant, play important roles in protection against the deleterious effects of lipid peroxidation [35]. Decreases in the activities of SOD, CAT and GPx in plasma, liver and kidney of KBrO3-treated rats may due to the decreased synthesis of enzymes or oxidative inactivation of the enzyme proteins. In the present study, increased lipid peroxidation associated with decreased antioxidant status in KBrO3-treated rats could therefore give rise to insufficient antioxidant potential.
The antioxidant effects of FR may be due to different causes: firstly, flavonoid's high diffusion into the membranes [36] allowed it to scavenge oxyradicals at several sites throughout the lipid bilayer; secondly, its pentahydroxyflavone structure allowed it to chelate metal ions via the orthodihydroxy phenolic structure, thereby scavenging lipid alkoxyl and peroxyl radicals [37, 38]. In spite of the free radical scavenging activities, flavanoid glycosides and phenols in FR might be also involved in the indirect induction of detoxifying genes [39], which might promote detoxification of KBrO3 and decrease their toxicity. In vivo studies have shown that flavanoid glycosides inhibited Fe2+-induced lipid peroxidation in the rat liver [40]. It is suggested that the lipid peroxidative indices were probably attenuated by the chain-breaking action of flavanoid in the free radical process of the oxidation of membrane lipids.
Our results also showed that the kidney was the major organ with the higher content of 8-OHdG after KBrO3 treatment, suggesting that the kidney is the main target organ of KBrO3-induced DNA oxidation. DNA damage was significantly decreased after the treatment of FR, which may be attributed to the antioxidant property of phenols in FR, as phenols are known to bind DNA at sites that would normally react with the active metabolites of carcinogen during carcinogen-DNA binding, a crucial step for initiation of carcinogenesis [41–43]. Alternatively, when the phenols bind to DNA, their molecules might be positioned in such a way so as to effectively scavenge reactive intermediates that approach the critical sites on DNA, or phenols may directly interact with the ultimate reactive metabolites of carcinogen by donating their electrons and rendering it inactive [44]. Dok-Go et al. demonstrated phenolsact in many cell-free experimental systems to scavenge reactive oxygen radicals and reduce oxidative DNA damage [45].
In summary, our data demonstrated that FR protected against KBrO3 toxicity by decreasing oxidant status and DNA damage and increasing the antioxidant status, indicating that FR possesses a spectrum of antioxidant and DNA-protective properties. However, further investigations are necessary to elucidate the precise mechanisms of protection of FR against KBrO3 toxicity, and the potential effects of FR against other carcinogens should be explored prior to evaluating as a chemopreventive agent against carcinogenesis.
|Fructus rhodomyrti
|Single-cell gel electrophoresis
|Reactive oxygen species
|Superoxide dismutase
|Reduced glutathione
|Glutathione peroxidase
Conflict of Interests
The authors declare no conflict of interests.
This work was supported by the National Natural Science Foundation of China (81072323/ H2607) and Shenzhen Basic Research Program (JC201105170713A). The authors are grateful to Dr. Xifei Yang from Key Laboratory of Modern Toxicology of Shenzhen, China, and Dr. Mak Ying-Tat from Chinese University of Hong Kong, Hong Kong, for their revisions.
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- A. W. Wood, M. T. Huang, R. L. Chang et al., "Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: exceptional activity of ellagic acid," Proceedings of the National Academy of Sciences of the United States of America, vol. 79, no. 18, pp. 5513–5517, 1982. View at Google Scholar · View at Scopus
- H. Dok-Go, K. H. Lee, H. J. Kim et al., "Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficusindica var. saboten," Brain Research, vol. 965, no. 1-2, pp. 130–136, 2003. View at Publisher · View at Google Scholar · View at Scopus


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Summary: DNS_ERROR_BAD_KEYMASTER errors could appears because that your windows system files are corrupted or damaged. Then you will find that your current application will be slower and response times lag as well. It's deserved to mention, when you have multiple applications running, you may come across PC crashes and freezing. The main source of these performance decreases are startup clutter, registry errors, RAM decline, fragmented files, unnecessary or redundant program installations, etc.
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Tuesday, January 24, 2012
by Kate Connolly from Diana Orgain's Maternal Instinct Mystery Series
I went for a wonderful hike on Lands End the other day. There is an area called Painted Rock Cliff. You may be able to tell from the photos that the trail goes up to the right and there is a stern warning not to go to the left with the quote "People have fallen to their death from this point. KEEP OUT"
Seems pretty clear, right? Why then did I witness a lone man standing beyond the sign perliously close to the edge, with his wife or lady friend simply looking on?
I had to stop and poke my nose around. I mean, how could you not? Especially after what happened with my friend's boyfriend....Well, so it's official then. I'm on a case. You have to read more about it later...as I discover it. But tell me, why do you think that man was walking on the edge of the cliff?
8 comments:
Ooooh, I'm intrigued...and he's crazy! Eeek, he must have a death wish.ReplyDelete
Good luck on your case.
He probably figured he was safe because he's never yet fallen off a cliff and died.ReplyDelete
Ha, ha, Edna!! I'll bet his wife dared him. She may have prevented him from seeing the sign. Fat insurance policy?ReplyDelete
LOL! I love these thoughts. Erika - too funny - Edna! You know they say...always follow the money!ReplyDelete
This is the kind of thing that gives your spine the tinglies!!ReplyDelete
What men do is a complete, utter mystery to me. But I bet he was up to no good. ;-)ReplyDelete
Some people like to live on the edge . . . .ReplyDelete
~ Krista
Maybe he didn't believe people have fallen.ReplyDelete
Subscribe to: Post Comments (Atom)


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I think a better approach is to look at how the gods would have fit into actual religious practice. Who worshipped them, and why? Here's one way of looking at it:
I. Tribal Divinities
The "intertribal" divinities are too numerous to discuss fully in this article but we can list the main ones. One can see them going in and out of "fashion" during the Iron Age, with some gaining in prominence while others fade away (exactly like what we see happening in Hinduism after the Vedic period). I'll use the names of the 'interpretatio Romana', not because I think the Romans had the right idea, but because they're consistent!
Because horses played such a large part in the Celts' military successes in Europe, the horse was a symbol of sovereignty and political power (as opposed to cattle, which were a symbol of the Land and of material wealth). Thus the goddess who gave legitimacy to the power of the tribe was portrayed as riding on a horse, or as a mare herself. This (Epona, "Great Mare") was a particular aspect of the sovereignty goddess, distinct from, say, Rosmerta, who gives rulers the intoxicating drink of flaith/wlatis. The Celtic "Minerva", on the other hand, was a more general representation of goddess-energy, who could be invoked in a far greater range of situations: she gave the energy of rulership to rulers, but also provided every other kind of energy wherever it was needed.
The Hindu model can be very useful in helping us understand the Celtic view of goddesses, which was quite similar. For Hindus, goddesses are sources of energy, and they are often referred to collectively as simply Shakti (which can be personified as Durga, the supreme virgin goddess who is the source of all energy in the universe). But when the energy is applied to a specific purpose, the goddesses become differentiated: as Sarasvati (culture and creativity), Lakshmi (fertility and wealth, material comfort) or Kali (destruction and rebirth). In the same way, virtually all the Celtic goddesses can be said to be sovereignty goddesses, Land-goddesses, etc, but they take on different names and attributes when required by specific circumstances.
I should add that the other animal specially related to Maponos (as hunter) is the boar, and it is through his participation in the ancient mythic device of the "Cosmic Boar Hunt" that the Light and Dark halves of the Year are defined (he dies at the threshold of the Dark half, of course). His consort is the Flower Maiden: his marriage to her marks the apex of his career of "growth".


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Google's executive chairman Eric Schmidt has admitted that the search giant should have put more effort into a Facebook-alike social network earlier.
In an interview with CNN, former CEO Schmidt expressed his frustration that his company had not worked on a more personal approach to the internet earlier.
"Fundamentally, what Facebook has done is built a way to figure out who people are. That system is missing in the internet as a whole. Google should have worked on this earlier," said Schmidt.
"I think that's the area where I would have put more resources, developing these identity services and ranking systems that go along with that. That would have made a big difference for the internet as a whole," he added.
Facebook has emerged as a true rival to Google web dominance, despite concerns over privacy.
With Google+ showing promising early signs, the question remains: could Facebook's social networking market share have been impacted if Google had got its act together earlier.
Via CNN
You can also check out our video hands on of Google+


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Miller School Pediatrics Chairman Publishes Editorial on Cardiotoxicity After Childhood Cancer
New Study Builds on UM Doctor's Breakthrough FindingSteven E. Lipshultz, M.D., professor and chairman of pediatrics and associate executive dean for child health at the University of Miami Miller School of Medicine, co-authored an editorial in the Journal of Clinical Oncology that was released online February 8. The editorial, written with M. Jacob Adams, M.D., M.P.H., of the University of Rochester School of Medicine and Dentistry, is titled: "Cardiotoxicity After Childhood Cancer: Beginning With the End in Mind." The editorial specifically comments on an original article in the same journal titled: "Role of Cancer Treatment in Long-Term Overall and Cardiovascular Mortality After Childhood Cancer."
Lipshultz is a leading authority on the late effects of treatment on survivors of childhood cancer, specifically the effects on the cardiovascular system when the survivors reach adulthood. In the editorial, the authors underscore the importance of further research to more specifically pinpoint specific treatments and the specific cardiovascular causes of death. As they point out, "the goal of childhood cancer treatment is not only to cure the patient, but to try to ensure that the patient lives as long and as normal a life as possible."
In the early 1980s, Lipshultz began noticing a high number of older children who had been treated for childhood cancer were experiencing cardiovascular effects later in life. As he and Adams state in their editorial, survivors of childhood cancer are five to 10 times more likely than their healthy siblings to experience heart disease.
This latest study involved a large population of over 4,000 survivors of childhood cancer with more than 86,000 patient-years of follow up and survivors who have died. Lipshultz says this work not only "confirms his concerns by showing the dramatic impact of cancer during childhood," it also adds new information about late cardiac effects by specifically calculating radiation doses to the heart as a factor to assess cardiovascular mortality. Children who received higher anthracycline doses (drugs such as Adriamycin) had more than a four-fold higher risk of having a cardiac death than children who did not receive anthracycline chemotherapy. This study found that as little as 5 Gy of radiation to the heart increased the risk of cardiovascular deaths. Hodgkin's lymphoma patients are treated with an average of 35 to 40 Gy of radiation.
Lipshultz and Adams argue that using genomics, proteomics and biomarkers to identify those childhood cancer survivors who are most at risk for cardiotoxicity requires much more research. Genetic predispositions along with personal health habits may also play a role. Lipshultz admits that devising cardio-protective treatments to avoid late heart failure is difficult because of an inadequate understanding of the risk-benefit ratio and the inherent challenges of running pediatric clinical trials, but points out the clear need. "Our work over the past 25 years has identified this as one of the largest new populations at risk for premature symptomatic cardiovascular disease, with one in every 560 young adults in the U.S. aged 20-45 years being a survivor of childhood cancer."
Until less toxic cancer therapies or better screening models are developed, these doctors encourage research involving all childhood cancer survivors and vigilant monitoring for possible cardiovascular disease. These findings however suggest that deliberate and intentional serial cardiac monitoring of childhood cancer survivors is needed not just for the children for whom recommendations exist, such as those treated with anthracyclines, but also for those who have received radiation to the heart or other chemotherapy identified in this study to be associated with cardiac mortality that was not previously noted to be cardiotoxic. In the meantime, Lipshultz says "it appears that for some of these survivors we have substituted one fatal disease of early childhood (cancer) for another fatal disease in early adult life."


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You are here
AstraZeneca's silence on CEO helps wipe out £3b
[LONDON] Uncertainty over the future of AstraZeneca Chief Executive Pascal Soriot drove the Anglo-Swedish drugmaker's shares lower again on Friday, taking the cost of two days of silence to more than £3 billion (S$5.338 billion).
AstraZeneca has repeatedly declined to comment on an Israeli media report on Wednesday that said the well-regarded Mr Soriot was in talks to join Israel's Teva Pharmaceutical Industries, the world's biggest generic drugmaker.
AstraZeneca shares closed 3.5 per cent lower on Thursday and were down 2.5 per cent on Friday at a two-month low after the company said it would not comment on rumours or speculation. One top 20 shareholder said there had been a "newsflow vacuum".
"It's hard because companies cannot be seen to be responding to every newspaper article because once you start you cannot stop. But as we all agree, if true, then timing is'interesting'," the shareholder said, on condition of anonymity.
The fall in shares since Wednesday has wiped £3.2 billion off AstraZeneca's market value, leaving it at £62 billion.
Moving to a generics drugmaker would be a big change in direction for French-born Soriot, 58, who had made research-based pharmaceuticals his whole drive at AstraZeneca.
The timing of the report has alarmed investors, coming as the company waits for all-important data from a lung cancer drug trial which is seen as a game-changer for Astra.
The company is hoping to secure a substantial slice of a multibillion-dollar market by proving its combination of two immunotherapy drugs, durvalumab and tremelimumab, can help previously untreated patients with advanced lung cancer.
The eagerly awaited results of the major trial, called Mystic, are due any day now.
Analysts at Leerink, an investment bank that specialises in healthcare, said Soriot's exit would come as a major surprise, if true, and leave AstraZeneca rudderless at a key time.
"We spoke with the company, who simply stated that it does not comment on rumours; however it did not outright deny the report," they said.
"If true, the optics around his departure would be terrible ahead of the Mystic readout."
AstraZeneca has already been shaken by the departure of the head of its European business, Luke Miels, whose defection to rival GlaxoSmithKline was a blow, and there have been a number of other senior management departures.
During his five years at AstraZeneca, Mr Soriot successfully defended the company against a US$118 billion takeover approach from Pfizer.
He also rebuilt AstraZeneca's drugs pipeline through research and acquisitions to replace revenue lost from a wave of patent expiries on many of its blockbuster medicines.
The Israeli Calcalist financial news website said Mr Soriot had met Teva's search committee and its chairman to express his agreement to serve as its next CEO.
It said he was expected to earn twice as much as former boss Erez Vigodman and receive a signing bonus estimated at about US$20 million. It said the financial terms were still being discussed.


text: Congenital syphilis is syphilis present in utero and at birth, and occurs when a child is born to a mother with syphilis. Untreated early syphilis infections results in a high risk of poor pregnancy outcomes, including saddle nose, lower extremity abnormalities, miscarriages, premature births, stillbirths, or death in neonates. Some infants with congenital syphilis have symptoms at birth, but...More


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Google Is Watching Us!
- Google Is Watching Us!
- The San Francisco Difference
Remembered how worried you were that Google was collecting your search habits and invading your privacy? You can drop that worry now, because I have a whole new Big Brother concern for you to grapple with. Google is taking 360-degree images of major cities across the US and tying them together with its increasingly popular Google Maps service, and in some of the photos, you can make out faces, license plates, and more.
Now you can start worrying.
When I first heard about this, I dismissed the concern. Amazon's A9 search engine started documenting street corners and intersections in major cities over a year ago. So I could virtually stand at the intersection of 28th and Madison and see my building and all the adjacent ones as well. There were people in these images, too, but I couldn't make out any of them.
Google maps, however, is a different storywell, a partially different story. I actually love the service because you can start out with a global or nation-wide view and zoom all the way down to the street address of your choice. At each level you get a new, and useful, view. You can see simple maps, complex maps, street and highway info, satellite imagery and local business information. It, like Yahoo Local and MSN Virtual Earth, is a powerful, free service.
I decided to check out the street view and see if things are really as bad as people say. I started by using an area I know wellNew York City. This is one of a handful of cities currently covered (though not 100 percent) by Street View. I virtually walked down Park Avenue and then moved to the narrowed streets of lower Manhattan. I "walked" up Church and then landed on Reade street (all intersections show which direction you're heading, and moving forward can be done by clicking in the direction you want to go on the image or holding your mouse down and dragging the image in your desired direction). In the image on the southeast corner of the street, I saw a woman. I zoomed in closer. She was obviously pregnant and wearing a white shirt, black pants, and a gray jacket. I could even tell that she had sunglasses on and was talking on her cell phone. That was kind of creepy.
I decided to see if I could find a way to identify her. I used the PrintScrn key to grab an image of my desktop and then pasted the desktop image into Adobe Photoshop. Then I zoomed in on her and applied an unsharp mask to try and sharpen up her features. No matter what I did, she still never became clear enough for me to say that I saw a "recognizable face." I tried this experiment with a number of images in the New York Maps and never got anything near a real face, no matter what I did in Photoshop.
Fine, I was satisfied that for all the "the sky is falling!" nervous nellies, Google was not in fact spying on us. No one would be caught going to a job interview or exiting a strip club.
No one except for unfortunate people living in San Francisco.next: The San Francisco Difference >


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Friday, December 19, 2008
Say Cheese Acrylic 16 x 16
This big guy was so much fun to paint. He has such good energy and quite the personality I couldn't resist using him as a model.
John K. Harrell Fine Art
Daily Impressionist Painters
2 comments:
- PAT MEYER -- said...
He looks like he is saying Cheese and is very happy about that.
- December 20, 2008 at 3:30 PM
- Aslam said...
Your art work is attractive and beautiful as compare to other artist work,i am also a artist my art work is presented in form of these cards on this website.
Plastic card printing
Gift card printing
Loyalty cards printing
PVC card printing
- December 23, 2008 at 3:59 AM
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We have homes ready for inspection and also homes to be purchased 'off the plan'. Please contact us to make an appointment to view the homes. Our stylish houses can viewed between the hours of 9am – 3pm or by appointment by phoning Karen during office hours on 02 4367 7789 or 0401 970-586.
To view our new homes for sale please click here


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New Music: "Lay You Down"-Ron Isley Featuring Trey Songz
As I reported Uncle Ron AKA Ron Isley released a new album yesterday 'This Song Is For You" on this new album we have old school meeting new school with the collaboration of Ron Isley and Trey Songz on the song "Lay Down" The song is a great collaboration, and their voice compliment each other very well! Ron Isley still has it, after so many years in the game.
Check It Out:


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When it comes to the technology in your business, it can often be a challenge to keep it running smoothly and working effectively. Frankly, many small business owners simply can't keep up and their business can suffer as a result. To avoid this, one of the smartest things you can do is outsource your IT to a Managed Service Provider (MSP).
What is an MSP?
When small to medium businesses look to outsource the management of their technology, many turn to a Managed Services Provider.


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I was working on an article last week about unusual marketing in public restrooms. I posed the question to my Facebook friends asking the most unexpected place they've found an ad. It was an immediate and varied response including some perspectives and experiences I was able to use in the article.
I am new to Facebook, but I am eager to share by participating in conversations online, getting opinions, sharing experiences and catching up with people who are very important to me—but I don't see on a regular basis. This has been a great joy connecting with people where miles and time have come between us. I have been surprised at how the joy and satisfaction of these relationships springs to life online.
The biggest surprise has been the new and rich ideas I am enjoying as a result of my new and what some might call, "friendsters" I'm meeting online. I am discovering new ideas and perspectives as I share my experiences and ask questions. For instance, a new Facebook friend who has a cleaning business focused on public buildings has a perspective on what many business owners do wrong to turn off people who visit their facilities. I know I have in the past made some judgments about a business based on a visit to their restroom. It isn't just cleanliness, but strong air freshener or even questionable colors, in a restroom can change the way visitors view a business.
At a time when we are all trying to do more with less to succeed in a down economy, I realize great ideas can come from anywhere. I'm excited to connect and talk with close friends and
those I don't know well, but are willing to share their thoughts and perspectives with me. My employer, SBTV.com has an online community especially for small business owners, self-employed, and aspiring entrepreneurs where you can connect, blog, podcast, and find resources online to grow and promote your business.
With all the ways to collaborate and collaborate online, more of us are sharing our lives with people who are further removed from our daily lives. I was wondering about the loss of privacy as we reach out into the world to connect and share. What do you think? Do you manage your social media to protect your privacy? Or are you bravely entering the wide new world of social media with abandon? Please let me know what you think and what you are doing. I'd also love to hear some of the memorable conversations or ideas you've learned or come across via social media.


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Flossing, brushing, and rinsing are the ABCs of dental hygiene, but these techniques are simply the beginning. An amazing smile takes much more than squeezing paste out of a tube, and thinking that your brushing techniques are enough to fight daily eating and drinking habits. Also, you have to say goodbye to cigarettes.
1. Pay A Visit To A Dentist
Research shows that 50% of American adults do not visit a dentist because they lack finances, dental phobia, and pure neglect. Toddlers and older adults tend to fly under the dental health radar but need dental care as the rest. When it comes to dental hygiene, age does not matter. According to the American Dental Association, it is wise to visit a dentist at least twice a year.
2. Soda And Sugar
There is no doubt about it, sugar and soda are not bad for your teeth. For example, what makes soda bad for your teeth are citric and phosphoric acids. They eat away the surface of the teeth. Even though occasional soda intake will not hart your teeth, daily consumption will soften the enamel, which can cause cavities. Sugar is known to cause tooth decay and this is the fact.
3. Avoid Smoking
This is something that has been mentioned over and over, and chances are that you have heard of it before. The tar and nicotine found in cigarettes not only turn teeth in a shade of yellow, but they also eat away at the gums. This is due to the fact that smoking creates a fertile environment for plaque and bacteria to thrive alone the gum line. This harms tissue, degrades bone that holds the tooth, which eventually will lead to tooth loss.
4. Use The Right Toothbrush
A proper toothbrush should be soft. With the right brushing techniques, an ordinary toothbrush should last you three months. They are easy to replace and should be replaced when first signs of bent bristles appear. Do not wait for long because even straight bristles tips can become blunted rather than rounded, which will cause injuries.
5. Flossing
Flossing is as important as brushing and encourages healthier tooth and gum. At the same time, just like brushing, there is a right way and wrong way of flossing. Doing it the wrong way may damage the gums. There are many benefits to flossing, one being that it helps to remove and clean substance off from the gaps of the teeth.
Visit this dentist in Greenbelt MD to find out what the best option is for your and your family!


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To promote understanding of our products, regular practical workshops are organized in the community.
The OME team is keen to provide outreach workshops in the community to demonstrate the features of our tools within imaging workflows. The training materials we develop are freely available along with the image data and setup procedures used.
Our workshops range in length from a 1-hour overview of OMERO up to a full day. For more detailed coverage, a 2-day workshop can be used to provide an introduction to OMERO on one day and more advanced analysis, developer or sysadmin features on the next.
Email firstname.lastname@example.com to discuss a workshop at your site.


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Lehigh Valley Rail Road Company was founded in 1864. Lehigh University's founder Asa Packer became the president in 1852 until his death in 1879. Under his management, LVRR expanded its web of railways Eastern Pennsylvania, New Jersey and New York. In 1897, it was controlled by J.P. Morgan. LVRR played major role in supplying anthracite, iron and steel from the Anthracite Region of Pennsylvania to the industrial centers, such as Buffalo, New York City and Philadelphia. LVRR was also an important passenger carrier in the same region. Its famous train was known as the Black Diamond Express. In 1962, it went under the control of Pennsylvania Rail Road, and in 1976 Conrail took over all the operations of LVRR.
Single volume ledger of Lehigh Valley Rail Road Company containing information on the locomotive and railroad car maintenance, repair and management records from 1863-1874. Entries organized chronologically by date.
The entries in the ledger are in chronological order.
SC MS 0159 Lehigh Valley Rail Road collection of schedules.
SC MS 0005 Asa Packer Estate Accounts and Financial Records
SC MS 0040 Estate of Harry E. Packer
SC MS 0156 Morris Canal and Bank Company records
This collection is open for research.
Collection housed remotely. Users need to contact 24 hours in advance.
Preferred citation for this material is as follows:
Cite as: Lehigh Valley Railroad Ledger 1863-1874, SC MS 0198, Special Collections, Linderman Library, Lehigh University, Bethlehem, PA
No additions anticipated.


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Infographic: How Mobile Payments Are Changing the World
In the past year, mobile payment systems have picked up steam and are now becoming mainstream. Could our wallets be replaced one day soon by our smartphones?
Back in 2002, MasterCard debuted its PayPass terminals, introducing instant payment processing to America. The system allowed MasterCard users to simple tap their credit card to the reader to make a payment. Today, more than 144,000 locations in the U.S. and over 311,000 locations worldwide use the PayPass system, according to MasterCard.
Then in November of 2010, AT&T, T-Mobile, and Verizon took this tap-and-pay system one step further, by aligning to create Isis, a mobile payment platform that utilizes near-field communication (NFC) technology to allow smartphone users to make payments with their phones rather than their credit cards.
One of the "Big Four" American phone carriers didn't join the party though: Sprint. As we found out in May of this year, it was holding out for Google's new NFC-based mobile payments ecosystem, Google Wallet. Launching with Sprint, MasterCard, and Citi later this summer, some analysts think this system will have what it takes for virtual wallets to finally succeed in the U.S.
The mobile payments idea is spreading far and fast. MasterCard, American Express, and Visa all offer virtual wallets. Twitter founder Jack Dorsey's mobile card reader, Square, is picking up speed. And eBay made a deal this week to purchase Zong, a company that specializes in allowing customers to pay for services through their wireless phone bill, for about $240 million in cash.
While Google succeeded in introducing a mobile payment service, via its Android app powered-Google Wallet, before its rival Apple (which is rumored to be working on an NFC payment system of its own), a June study found that iPhone owners are more excited about mobile wallets than Android users. Interestingly, the study also found that users trust their phone companies more than their credit card companies.
G+, a professional community service, created an infographic (below) illustrating how mobile payments are becoming the new credit card. It predicts the growth of the mobile payment market over the next four years and compares the current mobile payment contenders. Plus, it also displays a small graphic explaining how NFC technology works.Editor's Note: I've inserted the updated version of the infographic created by G+. The change reflects that American Express Serve also supports Visa, MasterCard, and Discover. [Source: G+]