text:
Our EP "B-Side Revenge" comes out today. You can listen and download it, enjoy the b/w clip of "Breaking Up" and leave your sincere opinion on our work. The sound is the one you already know, contaminated by some digital solution that makes this EP a necessary step to define our new album, scheduled for 2015. Tell us what you think people, we're not particularly touchy, feel free to say what you think! Rock on folks! DOWNLOAD
Tag: rock EP
Ready to go!
The 4 tracks that will make up our EP are traveling to be professionally mastered, Alex Marton will handle it. The sound is slightly different, but not too much. As soon as the treatment will be finished, the EP will receive a title and will be available for free download on our website.
Stay tuned, VH
Stay tuned, VH


text:
Amansara offers special access to Bauphon Temple in Cambodia
- Recommended Links
- Aman Resorts
- Cambodia luxury tours
- Aman Resorts wellness packages
Amansara Luxury Resort in Cambodia will be offering its guests special access to the 11th century Bauphon temple, which is not yet open to the public. Between 9 and 16 December, 2011, Professor Roland Fletcher, an expert in Asian archaeology at the University of Sydney and co-director of a research effort called the Greater Angkor Project, will be their annual Scholar in Residence and will escort guests to Bauphon and give them an insight into its unique history.
The temple, one of Cambodia's biggest after Angkor Wat, was built in 1060 by King Udayadityavarman II, in honour of the Hindu god Shiva. The rebuilding of the temple began in the 1960s when a French-led team of archaeologists dismantled the pyramid structure because it was falling apart. However, the restoration attempt was hampered by the country's civil war in the 1970s, when all records relating to the rebuilding of the temple were destroyed by the Khmer Rouge. Eventually the rebuilding started again in 1995 and the temple is now close to completion.
During Amansara's Scholar in Residence programme guests can also visit Angkor Wat and the West Mebon temple with Professor Fletcher.
A night at Amansara costs from £519 (US$850) per room per night plus tax and service. Each room comes with an English speaking driver/guide and a remork (motorised tuk tuk). There is a compulsory board and touring charge of US$125 per person per day, which includes breakfast, lunch or dinner plus house beverages and two outings a day with your guide and round trip airport transfers.
Wine Tasting in local home in Montenegro
Montenegro has been producing wine for centuries and in recent years its wine has been gaining a reputation amongst wine connoisseurs. Guests at the recently opened Aman Sveti Stefan can now visit the home of the Masanovic family, who have been making wine in Montenegro for centuries. Mr Masanovic and his family will offer you Vranac Barrique, a premium dry red wine, produced from the indigenous Vranac grape variety, which has been grown locally for centuries.
You will be able to taste the 2009 and 2010 vintages and will be offered homemade dried figs and walnuts from their own garden as well as Montenegrin pastries and cheese. Mr Masanovic also produces a wide selection of brandies including plum, grape, kiwi, apple and pear, which can also be tasted. If you wish Mr Masanovic will be more than happy to take you round the family vineyards and orchards located 2km from their home. The wine tasting trip costs from 150 euros per couple.
A night on the island of Sveti Stefan costs from £609 (700 euros).
A day in the life of a Lao rice farmer
Amantaka in Luang Prabang in Laos is encouraging its guests to spend a morning on the Living Rice farm in the countryside near Amantaka, which is surrounded by mountains and rice. This community enterprise focuses on growing rice and vegetables. Guests can immerse themselves in the daily life of a Lao farmer and try their hand at some of the various farm activities, such as planting rice or working the fields with buffalo.
A night at Amantaka costs from £427 (US$700) per room, including airport transfers, plus government tax and service charge.
New Trek in Bali
Guests staying at Amankila in East Bali can now explore the surrounding villages and historic buildings on a new four hour trek from the village of Tenganan to Tirta Gangga, one of the regency's iconic water palaces.
Tenganan is a storied village close to Amankila, famed for its basket weaving and double woven ikat material, which is believed to have magical powers. The traditions and ceremonies of the village date back beyond the Majapahit empire of the 16th century.
From Tenganan guests climb a ridge for a 360-degree view of the terraced rice fields and then they navigate their way through rice fields and traditional villages before reaching the Water Palace. The one hectare complex was built in 1946 by the late King of Karangasem, but was destroyed almost entirely by the eruption of nearby Mount Agung in 1963. It has since been rebuilt and restored. It has an eleven-tiered fountain as its centrepiece and is adorned with carvings and statues.
A night at Amankila costs from £519 ($850) per room, including concierge airport service and transfers, plus government tax and service charge.
You might also like
|Aman Resorts Introduces New Luxury Vacation Programs Recommended Links See All Aman Resorts Thailand Hotels & Resorts Amansara Resort Luxury...
|New Cambodia Private Island Resort Song Saa Recommended Links Cambodia Luxury Resorts Thailand Luxury Resorts Gorgeous villas over...
|Ultra Luxury Spa Resort in Utah: Amangiri of Aman Resorts Recommended Links View All Aman Resorts Utah luxury Vacations Discover one of the most...
|Aman Resorts Amanfayun offers for Hangzhou Tea Picking Season Recommended Links See All Aman Resorts Contact Aman Hotel Group China Luxury Hotels Longjing...

subset: commoncrawl


text: One Stop Cardiology Clinic « Back to Hospital » Find the right consultant BMI The Alexandra Hospital Breast Clinics Cardiac Surgery Opthalmology in Manchester Cardiology Services Children's Services Cosmetic Surgery Dietetic Services ENT Surgery General Medical Admissions Manchester Gynaecology Service Health Assessment at BMI The Alexandra Hospital Imaging services Mummy MOT Service Neurophysiology Neurosurgery Orthopaedics Physiotherapy Private GP Service Private Walk In Centre Richmond Oncology Centre The Nerve Clinic Weight Loss Surgery Women's Health A One Stop Cardiology Clinic is now available at BMI The Alexandra Hospital. The service is created to ease anxieties by being examined and getting your results in a single visit. The clinic offers: A full cardiology consultation ECG Echocardiogram Feedback on the results on the same day. The service is led by Consultant Cardiologist and Electrophysiologist Adam Fitzpatrick. Who can access the clinic? The service is available to anyone over the age 12 who has concerns about their heart or would like to get a second opinion. When is the clinic open? Mondays 1pm-3pm 5 appointment slots available How can I pay for my consultation? You can self-pay for your consultation and tests, or alternatively you can use your private medical insurance. To book an appointment or find out more about One Stop Cardiology Clinic please call us on 0161 495 7767 or make an online enquiry. Back to top Facebook Twitter Linked in Pinterest


text:
Our priority is to bring out the most beautiful bride in you!
With 20 years of experience in the Bridal Industry and recognised as one of Melbournes top 10 bridal hair and makeup artist award winning artistic educator Helen Donchos is the co-founder of the company H M ALLURE. The H M Allure team has been trained to be the best in the industry for bridal makeup artistry and wedding hairstyling in Melbourne. Our innovative experienced professional makeup artists and hairstylist specialist will assist in creating a look that brings out the most beautiful bride in you!
Our team of professional bridal makeup artist and hairstylist in melbourne, provide the ultimate journey to an artistic flair and talen,t creating flawless faces and creative bridal hairstyling.Specialising in classic and timeless wedding hair and makeup, contemporary and vintage looks a flawless natural and long lasting bridal makeover. Our premium products for hairstyling choice is Loreal professionnel Kerastase luxury hair care products ,Kevin Murphy, Evo Ghd as we know how important your hair is to you.Our choice of high end professional makeup products using HD makeup such as Temptu,Mac,Nars,Laura Mercier,Urban Decay your makeup will be flawless and long lasting
H M Allure offers a professional in salon and exclusive mobile service that travels to all areas of Melbourne and surroundngs so you can relax in your home,hotel suite whilist having your entire bridal beauty needs attented to. Book in your bridal makeup and hairstyling trial through our online booking system.Share your wedding hair and makeup ideas with our makeup artists and hairstylist during your consultation,and with our expert advise using the latest techniques our priority is to bring out the most beautiful bride in you!
We pride ourselves in providing the highest quality of personalised customer service.Pamper yourself on your wedding day with our Melbourne hair and wedding makeup services designed especially for you.
Helen was an absolute pro! Friendly and professional, she did such a great job with mine, bridesmaids and mother of the bride makeup. So amazing and knew exactly the look I was after. Makeup stayed all night despite some tears and didn't require touch ups at all. Thanks so much Helen!
Congratulations once again on your wedding day! You where a stunning bride.It was a pleasure been part on your special day I wish you all the very best for the future Regards Helen xx www.hmallure.com.au
Helen did both our hair and make up, we were all very happy with the job she did, everyone's hair and make up we're looking fantastic all night long! Would recommend her to friends!
Dear Jamie It was a pleasure been part on your wedding day you looked stunning! I wish you all the very best and I look forward to receiving some professional pics xx Warmest Regards Helen www.hmallure.com.au
Helen was beyond words absolutely amazing. She is extremely professional and a true artist when it comes to doing hair and makeup. I will be using Helen again for any other events I need to have my hair and makeup done in the future.
Dear Shimona It was a pleasure been part on your very special day you and your bridal party looked absolutely stunning !! Thank you for your lovely review and I wish you all the very best for the future. Warmest Regards Helen xx www.hmallure.com.au
Helen was fantastic. I was really nervous about having my hair done because I'm really fussy and I tend to do my own hair for occasions for this reason but she was amazing. She understood exactly what I had envisioned and she paired my hair and makeup to my wedding dress. Helen was so friendly and kind, and even talked me down when I started getting anxious. She also attended makeup for my MIL and my grandmother and they both looked lovely.
Get the best deals for your wedding with Easy Weddings only discounts and special offers.
Simply let us know which Easy Weddings' suppliers you've booked. Once verified, you'll get entries into the draw for your chance to win!
* Competition Excludes ACT
Your time is important. Get the information you need quickly. No fuss. No stress.


text:
Hot Stone Massage is a combination of massage and the use of hot stones- an ancient naturopathy that involves placing smooth, flat basalt stones preheated to approximately 125 °F (52 °C) on specific energy pathways of the body (usually the back, hands and toes) to alleviate back pain, arthritis, muscle ache and to release toxins inside the body.
Our therapist may also hold and glide the stones, use them to apply deeper pressure or to massage certain areas of the body. The warmth of the hot stones can greatly improve blood circulation and calm the nervous system, thus promoting deep relaxation in the underlying tissues.
Please note: women pregnant in the first trimester, or with health conditions such as blood clotting disorders, risks of pre-term labour and other ailments are not recommended for massage. Please consult with your doctor before experiencing pregnancy massage for the first time.
30 Mins Deep Tissue Oil Massage with Hot Stone
60 Mins Deep Tissue Oil Massage with Hot Stone
Note: Spa.com Gift Card is not acceptable.


text:
Music Is Life is a blog that will update its readers daily of whats popping in the music indusrty from the hottest new tracks to whos doing what so stay lock in to Mr Info uk for all the hottest news.
One Response to "About"
Dear sir/madam
My name is Joe Kelly and I am asking your permission for the use of your picture of Jay z for my Ict coursework. Would you be so kind to let me use this picture.


text:
Paper used for transcribing music to. Final product is called sheet music. Comes in various sizes, ranging from about half the size of a typical page of letter paper (folded lengthwise), all the way to landscape-oriented legal sized or larger, made for symphonic pieces.
Log in or register to write something here or to contact authors.
Sign up
Need help? email@example.com


text:
Complaint form and guide
Revised: December 2019
The Alberta Human Rights Commission is an independent commission of the Government of Alberta.
Due to confidentiality concerns, the Commission cannot reply to complaints of discrimination by email. Please contact the Commission by phone or regular mail if you have a specific complaint.
You can access information about making FOIP requests for records held by the Commission on our Contact us page.
The Commission will make publications available in accessible formats upon request for people with disabilities who do not read conventional print.


text:
Episode ${ video.episode_number }
${ video.title }
* Your list is public by default.
Alternative Titles
English: Fire Force
Synonyms: Fire Brigade of Flames
Japanese: 炎炎ノ消防隊
Type: TV
Episodes: 24
Status: Currently Airing
Aired: Jul 6, 2019 to ?
Premiered: Summer 2019
Broadcast: Saturdays at 01:25 (JST)
Producers: Mainichi Broadcasting System, Kodansha, bilibili, DMM pictures
Licensors: Funimation
Studios: David Production
Source: Manga
Genres: Action, Supernatural, Shounen
Duration: 23 min. per ep.
Rating: PG-13 - Teens 13 or older
Score: 7.601 (scored by 74,227 users)
1 indicates a weighted score. Please note that 'Not yet aired' titles are excluded.
Ranked: #14102
2 based on the top anime page. Please note that 'Not yet aired' and 'R18+' titles are excluded.
Popularity: #328
Members: 295,885
Favorites: 1,707


text:
Saturday, May 21, 2011
.....being a mother ..I can never advocate that a women should not have any kids , enjoy without bringing happiness to the family you are married to...
..I remember my mom always said "A women is never complete unless she is into motherhood"
...I am sorry if I have been rude to anyone!
9 comments:
- A said...
I thought your post was pretty balanced...some people like to get upset for no reason.
- May 21, 2011 at 5:14 PM
- Thinking said...
hmmm...everyon has their own way to see things...but it always astonsh me that why people get upset so easily...
Computers have option to close the webpage we don't want to look at...why take so much trouble and time to read the whole post and than get upset...?
hmmm...life is already very depressing...
Anyways...be happy Harman...and don't worry...it happened.
- May 22, 2011 at 3:04 AM
- Bikramjit said...
Well HArman.. beleive me you cant make everyone happy..
moreover its ur blog its yur right to write what u think is YOUR IDEA.
others shud respect that , yes they can voice there opinion but getting angry is not right.
thats what comments are for , discussion, what is right for u may not be right for them and vice versa
and chillax dont worry.. even readers should be open minded and look at the view of the writer ...
it works both way ...
take care now..
- May 22, 2011 at 6:12 AM
- Jack said...
You have full right to express your views and if someone does not like it he or she can move away. I fully support you on this issue as well as about having children. I made it quite clear in my comment on that. Those who visit have right to say what they wish to as long as it is withing decent limits. I will say, please carry on writing as your conscience permits regardless of anyone feeling otherwise.
Take care
- May 22, 2011 at 11:56 AM
- dr.antony said...
Come on,Harman. This is your blog and you can write the way you want.Don't expect everyone to agree to what we say.But we can respectfully disagree.
Keep on blogging!
- May 22, 2011 at 12:29 PM
- kavita said...
We stand by you Harman.I read the post and found it a balanced one.Don't worry too much about it :)
- May 23, 2011 at 3:49 AM
- Isabel said...
i think every blogger is sharing their opinions. its what we do :)
- May 23, 2011 at 8:32 PM
- AbhiLaSH RuHeLa said...
Now, I had no problems with your last post but I have problem with this post. Never do this in your lifetime again on your blog and even in your life. If u feel that something u said is right, no need to justify it just bcoz few people feel it as contradiction. I have written 400 blog posts till now and never apologized for any word to anyone. I have many Islamic friend. Wrote so much on Islam but never said sorry to anyone. What u feel iss right and u have the power to speak. So never again write such post which wud ask for apologies to anyone even when u know u havent said anything obnoxious.
- May 24, 2011 at 6:56 AM
- Harman said...
..@ everyone ...thanks ....
- May 24, 2011 at 8:11 PM


text:
Bomb Threats
Report threat immediately to the Assistant to the President, VP for Student Affairs and/or Campus Police. If it is determined that the report has merit, evacuation of buildings will be directed by Campus Police and building supervisors. This should be done in an orderly manner. All persons not involved in search will be moved to a minimum of 300 feet away from building or as directed by officer in charge. If a bomb is found, technical assistance will be requested from the nearest bomb disposal unit. Campus Police, together with building officials, will determine whether evacuation is required.
- Evacuation Not Ordered - The responding emergency team (campus police, Ellisville Police, etc…) in concert with employees in the affected area, might conduct a convert search. Employees will be asked to discreetly check their immediate work areas for any suspicious packages, devices, etc.
- Evacuation Ordered - The employees of the building will be evacuated 2000 to 3000 feet from the building and responding emergency teams will conduct a search of the area. Employees in the affected area may be asked to assist in identifying or conduction a brief search under the direction of the Incident Commander.
- Exact location of the bomb.
- Time set to explode.
- What does the bomb look like?
- What is the explosive?
- Why was it placed?
Obtain as much detailed information as possible about the bomb and its location. Legitimate callers usually wish to avoid injury or detection. Request more information by expressing a desire to save lives.
In the event of a bomb threat, immediately notify:
- The Dean of Men or Dean of Women
- The Campus Police--Police will notify proper officials
- The Dean of Men or Women will make the decision whether or not to evacuate after consultation with the Dean of Student Affairs and the Assistant to the President.
If evacuation is made:
- Do not touch any suspicious objects.
- Report anything out of the ordinary to residence hall personnel.
- Evacuation should be to a minimum of 300 feet.
Investigator's report:
- If you receive the call, make yourself available to investigating officers.
- Do not discuss the call with other personnel.


text:
The world is a chaotic place, where even a person who plans out their entire day can find themselves surprised by the unexpected. As John Lennon famously put it in his song "Beautiful Boy (Darling Boy)," "Life is what happens when you're making other plans." This is especially true in the fantastic world of the Marvel Universe, where surprises can come in the form of strange and wondrous phenomenon just as easily as from the comparatively mundane news from the family physician.
In this edition of THE COMMENTARY TRACK, writer Kelly Sue DeConnick joins us for a look at a day in the life of Carol Danvers, better known as Captain Marvel. DeConnick guides us through the pivotal pages of "Captain Marvel" #9, an issue that kicks off the next major arc of the series by taking readers inside Carol's personal world.
CBR News: We start this issue -- and the day -- with a glimpse at Carol's apartment, a place I don't think we've seen yet, or at least not much of, in this new "Captain Marvel" series.
Kelly Sue DeConnick: I asked in the script that Carol's apartment be something both homey and at least vaguely realistic for a New York apartment. I think Filipe Andrade accomplished both.
In this issue, you introduce us to quite a few supporting faces in Carol's life, starting with Dave, the breakfast cart guy. You live in Portland, a place famous for its food carts -- is Dave inspired by or based on anyone you've met or know there?
No. When I lived in NYC, I worked for a long time at 388 Greenwich, and there was a breakfast cart there that was staffed by the most high energy talk-a-mile-a-minute guy you could ever hope to encounter before you've had your second cup of coffee. I guess I was thinking of him? I'm making him sound annoying, but I actually like him a lot. He always made me smile and he referred to me as "cappuccino muffin" because I always got black coffee, no sugar, and a cappuccino muffin.
Damn, those muffins were good.
The name Dave is meant to be a nod to Dave Cockrum, who designed so many wonderful costumes, including Carol's former togs. Editor Steve Wacker has decided that Dave is brother to the coffee cart guy in "Daredevil."
Nice. I also think this page showed how in sync artist Filipe Andrade and colorist Jordie Bellaire are in terms of colors and pencils. It's a beautiful, bustling scene of a wintery city morning. What's it like working with these guys?
Jaw-dropping. This issue is so beautiful, I think.
Here we see Carol using her sash to help subdue one of the dinosaurs. This isn't the first time she's employed it in combat --
Right. It's been important to me from the beginning that it be a tool for her and not just a decoration.
This scene, and the fight before it, with the dinosaurs, helps to illustrate the friendship between Spider-Woman and Carol. Why do you think these characters click the way they do? What do you find most interesting about their friendship?
That Carol's the straight man, I guess. I think they're funny together, which is a thing I didn't really expect
Are you interested in exploring any of Carol's other established friendships in the super hero community like, say, with Jessica Jones-Cage?
Sure, yeah. And Aña Corazon, too. It's a matter of having a solid story reason tobring them in.
Here, Carol accepts a job as a pilot for Michael Air, Frank Gianelli's non-profit NGO. Why did you want to give Carol a job outside of her career as an Avenger? What do you feel it adds to the character and the book?
I think it gets Carol out in the world. We have talked from the very beginningabout wanting to show her as a hero, to show her making sacrifices to protect and serve the people around her. I wanted to show the people around her, find other ways for her to be a hero. Grow her world a little bit.
Carol suggests that Frank is trying to get her to agree to the job by daring her. Frank's answer is that people often get Carol to do things by daring her. Why is that? Does Carol have a subconscious need to prove things to people?
Ha! I don't know that it's so subconscious. I think she's in a constant state of proving herself, even when no one's doubting her.
I notice we don't find out why the people were pointing guns at Frank. I assume you'll pick up on that later in this story --
I think you'll get that answer in issue 11.
Finally, the issue ends with a revelation that for her own safety, Carol can not fly. Now, Carol has been through a lot in her long super hero career, and she's coped with loss and tragedy in positive ways and some not so positive ways. How do you think those past losses and tragedies have affected her? And do you think they have made her better able to deal with being grounded?
I don't think she's going to handle it well at all, honestly. Obeying doctor's orderswould feel like defeat to her, and Carol doesn't lose with any grace.


text:
On January 13, 2016, the Federal Trade Commission (FTC or the Commission) released an overview of the pharmaceutical patent settlements filed with the Commission in Fiscal Year 2014 (October 1, 2013 – September 30, 2014). The FTC has published similar reports annually since the passage of the Medicare Modernization Act of 2003, which requires parties that settle patent infringement litigation brought pursuant to the Hatch-Waxman Act to file copies of their agreements with the FTC and the Department of Justice. The FTC's latest report reflects the second full year of agreements following the U.S. Court of Appeals for the Third Circuit's decision in In re K-Dur Antitrust Litigation, 686 F.3d 197 (3d Cir. 2012), and the first full year of agreements following the Supreme Court's decision in FTC v. Actavis, 133 S. Ct. 2233 (2013).
Reports before FY 2013 predominantly reflected settlement practices under the "scope of the patent test," the once-prevailing standard for evaluating Hatch-Waxman settlements. Under the scope of the patent test, a settlement containing a "reverse payment" from the patent holder to the alleged infringer does not warrant antitrust scrutiny so long as the settlement's exclusionary scope is no greater than that created by the patent in dispute. In K-Dur, the Third Circuit broke with the other courts of appeal, rejecting the scope of the patent test and holding that any reverse payment accompanied by delayed generic entry should be treated as prima facie evidence of an unreasonable trade restraint and reviewed under a quick look test. Then, less than one year later, in Actavis, the Supreme Court rejected both the quick look test and the scope of the patent test, holding that where a plaintiff alleges a large and otherwise unjustified reverse payment, the settlement should be reviewed under the traditional rule of reason analysis.
According to the FTC report, Hatch-Waxman litigants filed 160 final settlements with the FTC in FY 2014. This number is a slight increase compared to the number of final settlements filed in fiscal years 2013 (145), 2012 (140) and 2011 (156). However, the Commission does not report whether the total number of Hatch-Waxman cases has changed over time, so it is unclear whether the percentage of patent infringement cases that ultimately settle has changed. Of the 160 reported settlements, the FTC reports that 21 "potentially involve pay for delay."1 For another eight, the FTC said it was "not clear from the face of each settlement agreement whether certain provisions act as compensation to the generic patent challenger." The remaining 131 agreements, according to the Commission, involved no payment from the patent holder to the alleged infringer: 20 allowed immediate generic entry and 111 allowed generic entry at a later agreed-upon entry date, but involved no compensation to the generic.
Much like the FTC's report last year, the FY 2014 report sheds little light on the Commission's view regarding the scope of appropriate antitrust scrutiny for reverse payment settlements. The report makes it clear that the FTC believes at least some level of review should occur when the agreement involves a side business deal, precludes the brand from competing during the term of an early entry license (e.g., a so-called "no authorized generic" agreement), or includes a cash payment. What is not clear is whether, in the Commission's opinion, all agreements involving cash payments or side business deals "potentially involve pay for delay," or whether (or when) it believes license terms other than exclusivity (e.g., supply arrangements and royalty payments) merit antitrust review. For example, for the second straight year, the FTC classified an agreement in which the generic's obligation to pay royalties was reduced or eliminated if the brand company launched an authorized generic as an agreement where it was "not clear" whether there was a reverse payment. The report does not elaborate on any other agreements the FTC deemed difficult to classify.
From the FTC's perspective, the number of "potential" reverse payment settlements has substantially declined. The 21 potential reverse payment agreements reported in FY 2014 is the lowest since FY 2009, and the percentage of final settlements that the FTC deemed potential reverse payment settlements is the lowest since FY 2005. Also, the number of "potential" reverse payment deals involving first filers, which in the Commission's view present special concern because of the potential to block other generic entry, was the lowest since FY 2007 and the lowest as a percentage of final settlements since FY 2005.
The FTC's report suggests that litigants not only have attempted to avoid potential reverse payments entirely, but also have shifted the types of consideration exchanged in Hatch-Waxman settlements. For example, nine of the FTC's 21 "potential pay-for-delay" settlements included compensation solely in the form of a cash payment of less than $5 million, purportedly to cover litigation fees. The prevalence of such payments accords with the Actavis Court's express endorsement of settlements reflecting avoided litigation costs. Similarly, the Supreme Court suggested that a fair value payment for services rendered would be deemed "justified," and six of the FTC's 21 "potential pay-for-delay" settlements involved compensation in the form of a side business deal.
The FTC reported fewer agreements — five in FY 2014 and four in FY 2013, compared to 19 and 11 in FY 2012 and FY 2011, respectively — in which the Hatch-Waxman litigants agreed to an exclusivity term that barred the brand manufacturer from marketing an authorized generic in competition with the generic manufacturer's product. Migration away from this license term is not surprising, given the FTC's well-publicized position that such exclusive licenses are a form of reverse payment. The Third Circuit's decision in June 2015 that such settlements are subject to rule of reason review2 may push the number of agreements involving exclusive licenses even lower in the FTC's next report.
Followers of Hatch-Waxman litigation will eagerly await the FTC's FY 2015 report to see how ongoing litigation over the definition of "payment," and the several cases expected to be reviewed by circuit courts of appeal this year, will affect these trends.
1 The 21 agreements involve 20 different branded pharmaceutical products, with combined annual U.S. sales of about $6.2 billion.
2 King Drug Co. of Florence, Inc. v. SmithKline Beecham Corp., 791 F.3d 288 (3d Cir. 2015).
The material in this publication was created as of the date set forth above and is based on laws, court decisions, administrative rulings and congressional materials that existed at that time, and should not be construed as legal advice or legal opinions on specific facts. The information in this publication is not intended to create, and the transmission and receipt of it does not constitute, a lawyer-client relationship.


text:
Dietary Sodium Restriction Reverses Vascular Endothelial Dysfunction in Middle-Aged/Older Adults With Moderately Elevated Systolic Blood Pressure
Author + information
- Received July 2, 2012
- Revision received August 29, 2012
- Accepted September 11, 2012
- Published online January 22, 2013.
Author Information
- Kristen L. Jablonski, PhD⁎,
- Matthew L. Racine, MS⁎,
- Candace J. Geolfos, BA⁎,
- Phillip E. Gates, PhD†,
- Michel Chonchol, MD‡,
- Matthew B. McQueen, ScD⁎ and
- Douglas R. Seals, PhD⁎,⁎ (seals{at}colorado.edu)
- ↵⁎Reprint requests and correspondence:
Dr. Douglas R. Seals, Department of Integrative Physiology, University of Colorado at Boulder, 354 UCB, Boulder, Colorado 80309
Objectives This study sought to determine the efficacy of dietary sodium restriction (DSR) for improving vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure (SBP) (130–159 mm Hg) and the associated physiological mechanisms.
Background Vascular endothelial dysfunction develops with advancing age and elevated SBP, contributing to increased cardiovascular risk. DSR lowers BP, but its effect on vascular endothelial function and mechanisms involved are unknown.
Methods Seventeen subjects (11 men and 6 women; mean age, 62 ± 7 years) completed a, randomized crossover study of 4 weeks of both low (DSR) and normal sodium intake. Vascular endothelial function (endothelium-dependent dilation; EDD), nitric oxide (NO)/tetrahydrobiopterin (BH4) bioavailability, and oxidative stress-associated mechanisms were assessed following each condition.
Results Urinary sodium excretion was reduced by ∼50% (to 70 ± 30 mmol/day), and conduit (brachial artery flow-mediated dilation [FMDBA]) and resistance (forearm blood flow responses to acetylcholine [FBFACh]) artery EDD were 68% and 42% (peak FBFACh) higher following DSR (p < 0.005). Low sodium markedly enhanced NO-mediated EDD (greater ΔFBFACh with endothelial NO synthase inhibition) without changing endothelial NO synthase expression/activation (Ser 1177 phosphorylation), restored BH4 bioactivity (less ΔFMDBA with acute BH4), abolished tonic superoxide suppression of EDD (less ΔFMDBA and ΔFBFACh with ascorbic acid infusion), and increased circulating superoxide dismutase activity (all p < 0.05). These effects were independent of ΔSBP. Other subject characteristics/dietary factors and endothelium-independent dilation were unchanged.
Conclusions DSR largely reversed both macro- and microvascular endothelial dysfunction by enhancing NO and BH4 bioavailability and reducing oxidative stress. Our findings support the emerging concept that DSR induces "vascular protection" beyond that attributable to its BP-lowering effects.
Cardiovascular disease (CVD) remains the leading cause of death in the United States, and the risk for CVD increases progressively with age (1). Vascular endothelial dysfunction, as reflected by impaired endothelium-dependent dilation (EDD) of conduit arteries and/or resistance vessels (2), is a predictor of CVD and CV events (3,4). EDD is reduced in middle-aged and older adults in the absence of major risk factors or clinical CVD (5). Systolic blood pressure (SBP) also increases with advancing age (6), resulting in ∼65% of adults 50 years of age and older with SBP ≥130 mm Hg (7). Importantly, the age-associated impairment of EDD is even greater in middle-aged and older adults with elevated compared with normal SBP (2,8).
Dietary sodium restriction is a commonly recommended lifestyle modification for reducing the risk for CVD (9). Based on recent analyses, the projected health and societal benefits resulting from population-wide dietary sodium restriction (DSR) would be substantial (10). To date, such projections have focused on the effects of DSR on BP. However, high dietary sodium intake has adverse cardiovascular effects independent of BP (11,12). Evidence from animal models and acute salt loading or cross-sectional observations in humans suggests a negative association between sodium intake and vascular endothelial function (11,13–16). However, presently it is unknown whether DSR can reverse endothelial dysfunction in the common clinical setting of aging and elevated SBP.
The physiological mechanisms by which DSR may improve vascular endothelial function in humans are also unknown. Available data from rodent models suggest that high-sodium diets may impair EDD by reducing nitric oxide (NO) bioavailability as a result of oxidative stress (14,17). This may be mediated via oxidation and reduced bioavailability of tetrahydrobiopterin (BH4) (18), an essential cofactor for endothelial nitric oxide synthase [eNOS]-mediated NO production, which causes uncoupling of the enzyme (14,18). Limited data in rodents suggest that high sodium also may reduce the expression of eNOS (19) and suppress the activity of superoxide dismutase (SOD), an important antioxidant enzyme (20).
The aim of this study was to determine whether DSR improves vascular endothelial dysfunction in middle-aged/older adults with moderately elevated SBP by increasing NO and BH4 bioavailability and reducing oxidative stress.
Using a double-blind, placebo-controlled, randomized crossover design, both conduit artery (macrocirculatory) and resistance vessel (microcirculatory) EDD, as were the putative physiological mechanisms involved, were determined under well-controlled conditions of low (DSR) and normal dietary sodium intake. Vascular NO and BH4 bioavailability and oxidative stress were assessed by "pharmaco-dissection" using agents that either inhibited or enhanced these processes, whereas eNOS protein expression and activation (phosphorylation at Ser 1177) were measured in endothelial cells obtained from arterial sampling.
The study was conducted in the University of Colorado-Boulder Clinical and Translational Research Center (CTRC), and blood and urine assays were performed at the Colorado Clinical Translational Sciences Institute CTRC Core Lab, University of Colorado–Denver Anschutz Medical Campus.
Enrolled subjects were 50 to 79 years of age and had a SBP of 130 to 159 mm Hg (i.e., high-normal or stage I systolic hypertension), with diastolic BP <99 mm Hg, verified on a minimum of 2 occasions, as described previously (21,22). These criteria were chosen to encompass the resting BP values of the majority of middle-aged and older adults at higher BP-related risk for CVD (7,23). Enrolling subjects with high-normal and stage I hypertension also increased the likelihood of assessing adults who were more salt-sensitive at baseline, as salt sensitivity increases with increasing resting BP (24). All subjects were otherwise free of CVD, diabetes, kidney disease, and other clinical disorders. Details of inclusion and exclusion criteria can be found in the Online Appendix.
Twenty middle-aged and older men and women were enrolled in the study (see Online Figure for CONSORT diagram). Three subjects withdrew after beginning DSR (see subsequent discussion), but prior to completing the first set of vascular measurements (1 was uncomfortable with study procedures; 2 decided that they could not comply with the diet). The remaining 17 subjects (ages 51 to 77 years; 11 men and 6 post-menopausal women) completed the entire 10-week protocol. All procedures were approved by the institutional review board of the University of Colorado at Boulder. The nature, benefits, and risks of the study were explained to the volunteers and their written informed consent was obtained prior to participation.
Experimental design and dietary sodium restriction
A double-blind, placebo-controlled, randomized crossover design, originally described by Cappuccio et al. (25) and more recently by our group (21), was used. A low sodium target of 50 mmol/day (1,200 mg/day) was set, with the anticipation that actual mean intake would be ∼65 mmol/day (1,500 mg/day), consistent with the DASH (Dietary Approaches to Stop Hypertension) diet (26). This was compared to the mean ("normal") U.S. sodium intake of 150 mmol/day (3,600 mg/day) based on recent National Health and Nutrition Examination Survey dietary intake data (27). During the entire 10-week intervention period, subjects were instructed to reduce their dietary sodium intake to a target of ∼50 mmol/day and to take a total of 10 tablets throughout the day, with meals. For 5 of the weeks, the tablets were placebo pills, whereas for the other 5 weeks, the tablets were slow-release sodium chloride tablets (10 mmol [0.23 g] per tablet) (HK Pharma Ltd., Hitchin, United Kingdom). The slow-release salt tablets aimed to return sodium intake to the ∼150 mmol/day target.
Following screening, subjects were provided with comprehensive dietary education and counseling by CTRC bionutritionists to reduce dietary sodium intake without changing caloric intake, dietary composition, or potassium intake. Vascular measurements were performed after 4 weeks (i.e., during the fifth week) of each condition. Details of the experimental design can be found in the Online Appendix.
Blood pressure, clinical characteristics, assays, and diet analysis
Brachial artery BP was assessed under quiet resting conditions, with the subject in the supine position, using a semiautomated device (Dynamap XL, Johnson & Johnson, Raritan, New Jersey) in accordance with the Joint National Committee guidelines (28), as described previously (21). SOD activity was measured in plasma samples (n = 12 of 13) using a commercially available colorimetric kit (Cell Technology, Inc., Mountain View, California) (29). Twenty-four-hour urinary sodium and potassium excretion values were measured weekly as a quantitative maker of dietary intake (Fig. 1). CTRC bionutritionists analyzed a 3-day diet record logged by subjects at baseline and at the end of each sodium condition, as described previously (21). For details of these measurements, as well as assessments of other subject characteristics, please see the Online Appendix.
Conduit artery endothelium-dependent and -independent dilation
Brachial artery flow-mediated dilation (FMDBA), estimated peak shear rate, and endothelium-independent dilation (brachial artery dilation to 0.4 mg of sublingual nitroglycerin) were determined using duplex ultrasonography (Power Vision 6000, Toshiba Corp., Tokyo, Japan) with a 7.5-MHz adjustable (6 to 11 MHz) linear array transducer, as described previously (30,31). BH4 modulation of EDD was determined by measuring FMDBA ∼3 hrs after oral administration of BH4 or placebo tablets (32) (n = 14/15), and the influence of oxidative stress on FMDBA was assessed by infusing a supraphysiological dose of ascorbic acid or isovolumic saline during each of these visits (BH4 and placebo days), as described previously (31,33) (n = 12 to 17). See the Online Appendix for details.
Resistance vessel endothelium-dependent and -independent dilation
Forearm blood flow (FBF) was measured in the experimental (catheterized) and the control forearm with strain-gauge venous occlusion plethysmography (AI6 Arterial Inflow System, D.E. Hokanson Inc., Bellevue, Washington), as previously described (n = 12 of 13) (34). All FBF values are presented as percentage increases in flow (ml/100 ml forearm tissue/min) in response to intrabrachial artery drug infusion (acetylcholine [ACh], sodium nitroprusside, ACh + NG monomethyl-L-arginine or ACh + ascorbic acid) compared with saline control. Forearm vascular conductance (FVC) was calculated from intra-arterial BP and FBF (FVC = FBF/mean arterial pressure) to account for any differences in arterial BP between sodium conditions. See the Online Appendix for details.
Endothelial cell protein assessments
The procedures for collection and analysis of arterial endothelial have been described in detail previously (30,31). Vascular endothelial cells were obtained from the brachial artery and analyzed for expression of total eNOS and eNOS phosphorylated at Ser 1177 using immunofluorescence imaging (n = 12/13). For details, please see the Online Appendix.
Changes in EDD in response to dietary sodium restriction (DSR vs. normal sodium condition) were analyzed using a series of linear mixed-effects models (Online Table 1; see Online Appendix for details and power calculations). Differences in other variables were assessed using paired t tests (between sodium conditions) or repeated measures analysis of variance with post hoc Bonferonni corrected comparisons (sodium conditions vs. baseline). Bivariate relations were determined using the Pearson correlation coefficient. All data are reported as mean ± SD.
Clinical characteristics and efficacy of DSR
Subjects were non-Hispanic Caucasian (88%) or Asian (12%) with a mean age of 62 ± 7 years (Table 1). They successfully reduced sodium intake without altering potassium intake based on both urinary excretion (sodium: 151 ± 37 mmol/day, baseline; 153 ± 27 mmol/day, normal sodium condition; 70 ± 30 mmol/day, DSR [week-5 values]) (Fig. 1) and dietary analysis (Table 2). Other than sodium intake, diet composition was unchanged (Table 2). As anticipated, SBP was reduced during DSR, but other clinical characteristics, including diastolic BP, were unaffected (Table 1). Circulating humoral factors also were unchanged (Table 3).
Effects of DSR on conduit artery (macrocirculatory) endothelial function
FMDBA was 68% greater during DSR versus normal sodium condition (%Δ: 6.01 ± 2.31 vs. 3.57 ± 1.69; p < 0.001) (Fig. 2A). The response was consistent with all but 2 subjects demonstrating higher FMDBA with DSR versus the normal sodium state (Fig. 2B). When the 2 sodium conditions were pooled, there was a significant inverse correlation between sodium excretion and FMDBA (r = –0.48; p < 0.01). The difference in FMDBA between sodium conditions remained significant (p < 0.001) after corrections for SBP and medication use, and ΔSBP with DSR did not correlate with ΔFMDBA (r = –0.05; p = 0.85). No trends for sex differences were observed, although the study was not powered to detect such differences. Baseline brachial artery diameter and shear rate did not differ across sodium conditions (Table 4) or with ascorbic acid with or without BH4 administration, and the difference in FMDBA between conditions remained significant (p < 0.001) when covarying for these factors. Endothelium-independent dilation to sublingual nitroglycerin was unaffected by DSR (Table 4). The associated mixed-effects regression models are shown in Online Table.
Effects of DSR on resistance vessel (microcirculatory) endothelial function
DSR improved EDD to ACh, whether expressed as FBF (+42% at peak dose) or as BP-corrected forearm vascular conductance (+52% at peak dose) (both, p < 0.05) (Figs. 3A and 3B). EDD also was greater with DSR versus the normal sodium state when expressed as area under the dose–response curve (Table 4). Again, the effect of DSR was consistent among the subjects, with all but 2 individuals demonstrating higher values for area under the dose–response curve of FBFACh compared with the normal sodium state (Fig. 3C). The FBF and FVC responses to the endothelium-independent dilator sodium nitroprusside were unchanged across sodium conditions (Table 4). FBFACh in the control arm did not change with sodium condition or drug infusions (not shown).
Effects of DSR on EDD: NO bioavailability
Coinfusion of the eNOS inhibitor NG monomethyl-L-arginine markedly reduced FBFACh and BP-corrected FVC with DSR but not during the normal sodium condition (Figs. 4A to 4D). As a result, FBFACh no longer differed between DSR and the normal sodium condition during eNOS inhibition, indicating increased NO bioavailability during DSR. In vascular endothelial cells sampled from the brachial artery, eNOS protein expression and activation, the latter indicated by phosphorylation at Ser 1177, did not differ between sodium conditions (Figs. 4E and 4F).
Effects of DSR on EDD: oxidative stress and BH4 bioavailability
Infusion of ascorbic acid increased FMDBA during the normal sodium condition (+37%; p < 0.05), but not during DSR (Fig. 5A), indicating reduced oxidative stress–related suppression of EDD during DSR. Similarly, oral BH4 administration improved FMDBA only in the normal sodium state (+65%; p < 0.005) (Fig. 5A). No further improvement in FMDBA was observed when ascorbic acid and BH4 were coadministered (Fig. 5A). FMDBA no longer differed between DSR and the normal sodium condition following the administration of ascorbic acid and/or BH4. These responses were independent of the sodium condition–related influence on SBP. Endothelium-independent dilation to nitroglycerin did not change with ascorbic acid + BH4 during either sodium condition (data not shown). Circulating SOD activity was modestly greater (p < 0.05) during DSR versus the normal sodium condition (Fig. 5B).
Coinfusion of ascorbic acid also improved FBFACh (peak dose: +57%) under the normal sodium condition compared with DSR (Fig. 5C). FBFACh no longer differed between DSR and the normal sodium condition during coinfusion of ascorbic acid. Results were similar when EDD was expressed as forearm vascular conductance (Fig. 5D).
The present findings show that restricting dietary sodium intake to a level consistent with the DASH diet improves both conduit artery (macrovascular) and resistance vessel (microvascular) endothelial function in middle-aged/older adults with moderately elevated SBP, a large clinical demographic with significant CVD risk burden. The results also provide insight into humans regarding the physiological mechanisms mediating improvements in vascular endothelial function with DSR, which include increased NO and BH4 bioavailability and reduced oxidative stress. None of the vascular effects observed were related to changes in BP, other dietary factors, clinical characteristics, or humoral influences. Overall, the findings support the emerging concept that maintaining low dietary sodium intake exerts "vasculoprotective" effects beyond those attributable to BP lowering.
DSR and vascular endothelial function
The present results demonstrate that DSR improves EDD as assessed by both FMDBA, a measure of peripheral conduit artery dilation to a mechanical (shear) stress, and FBFACh, an assessment of resistance vessel EDD in response to a chemical stimulus. These findings are in agreement with those from previous reports of impaired EDD in animals (13,18) and younger humans (11,15) following a high sodium load, as well as improved FMDBA after short-term sodium restriction in overweight/obese, normotensive adults (35). The improvements in both micro- and macrocirculatory EDD with DSR in the present investigation were observed in almost all subjects and did not differ between the men and women studied. We also found that conduit artery EDD (FMDBA) was inversely related to urinary sodium excretion, an objective measure of dietary sodium intake.
The reduction in SBP with low sodium (12 mm Hg) was similar to those from previous studies on dietary sodium restriction (21,22) and was consistent with those from other crossover studies employing well-controlled BP assessments (25,36). The present magnitude of reduction was observed despite the inclusion of subjects on antihypertensive medications. Importantly, the improvements in EDD with DSR remained significant after statistically correcting for SBP, and the changes in EDD were not related to the changes in SBP, whereas diastolic BP was unaffected. Thus, DSR improved vascular endothelial function beyond its influence on BP alone.
Physiological mechanisms
High sodium intake in younger humans and rodents impairs EDD by reducing NO bioavailability (13–15), and the chronic impairment in EDD in salt-sensitive compared with salt-resistant adults with hypertension is associated with reductions in bioavailable NO (37). Consistent with these observations, in the present study, lowering dietary sodium improved resistance vessel EDD by increasing NO bioavailability. The latter was not obviously associated with changes in eNOS or its activation, as eNOS protein expression and phosphorylation of eNOS at Ser 1177 did not differ between sodium conditions in vascular endothelial cells obtained from brachial artery sampling.
In rodents fed a high-salt diet, impairments in EDD are linked to reduced bioavailability of BH4, an essential cofactor for NO production by eNOS (18), as well as oxidative stress (14,17), as indicated in part by improved EDD following acute administration of an antioxidant (17). In the present study, a single oral dose of BH4, previously shown to improve EDD in settings of endothelial dysfunction (32), improved EDD (FMDBA) during normal, but not low sodium intake. Moreover, infusion of supraphysiological doses of ascorbic acid (vitamin C), a well-established method for acutely reducing oxidative stress-related suppression of EDD (8,33), improved both conduit artery (FMDBA) and resistance vessel (FBFACh) EDD during normal, but not lower, sodium intake. Indeed, the administration of BH4, ascorbic acid, or both abolished the differences in EDD between the normal- and low-sodium conditions. A modest but significant increase in circulating SOD activity was also found with DSR, in agreement with the inhibitory effects of high-salt feeding on SOD reported previously in rats (20).
BH4 bioavailability modulates NO-mediated EDD in the absence of changes in eNOS protein expression or activation (38). Without adequate BH4, eNOS is "uncoupled," producing more superoxide anion and less NO (39). It is possible that DSR "recoupled" eNOS, increasing NO production without further activation of the enzyme. The apparent increase in BH4 bioavailability with DSR most likely was mediated by reduced oxidative stress, as reactive oxygen species, particularly peroxynitrite formed by the reaction of superoxide and NO, readily oxidize BH4 to its inactive form, BH2 (39). Alternatively, DSR may have increased NO bioavailability by inhibiting superoxide production by oxidant enzymes such as NADPH oxidase or by mitochondria, resulting in less superoxide to react with/reduce the bioavailability of NO.
Clinical significance
The concept that high sodium intake has adverse CV effects independent of BP has been advanced previously (9,12). High dietary sodium impairs EDD even in rodents that are salt-resistant and, thus, do not exhibit increases in BP in response to a high-salt diet (13,18,20). Acute impairment of EDD in normotensive adults after sodium loading also is BP independent (11), and adults with elevated SBP who report lower sodium intake have enhanced EDD independent of BP (16). The present results extend these findings to sodium restriction and lend support to the overall hypothesis that sodium intake not only elevates BP but also exerts other adverse influences (12). The effects of sodium restriction on endothelial function reported here also complement previous findings that reducing sodium intake can rapidly de-stiffen large elastic arteries (21), another independent vascular risk factor for CVD (40). The improvements in these 2 common forms of arterial dysfunction, both predictors of CV events (3,4,40), suggest that DSR has strong potential for reducing CVD risk via broad vasculoprotective effects.
Strengths and limitations
Diet was well-controlled in the present study, with only sodium intake differing between the 2 conditions, as documented by "gold-standard" 24-hr urine collections combined with diet records. This feature, along with the placebo-controlled crossover design employed, allowed for the isolation of dietary sodium as the modulating factor between conditions. Importantly, the results are generalizable to community settings in that sodium restriction was achieved by subjects on their own, guided by dietary counseling, rather than delivered as prepared meals in a research setting. The assessments of macro- and microcirculatory endothelial function, both of which are involved in age- and BP-related CV pathology, as well as the unique insight into mechanisms of action acquired by the use of novel translational research techniques, are additional strengths of the study.
Due to the complexity, burden, and, in some cases, invasiveness of the study design and procedures, only a limited number of subjects could be studied. However, as recently emphasized by Donald et al. (41), a much smaller sample size is required when assessing EDD using a crossover compared with a parallel-group design, as shown in previous investigations (31,42). As such, the study was well powered to assess change in EDD (Online Appendix), and importantly, the approach allowed investigation of the mechanisms underlying the beneficial vascular effects of low sodium intake at a depth and level of detail that would not be possible in large cohorts.
The results of the present study support the hypothesis that DSR to a level consistent with the Dietary Approaches to Stop Hypertension diet improves both conduit artery (macrovascular) and resistance vessel (microvascular) endothelial function in middle-aged/older men and women with elevated SBP by increasing NO and BH4 bioavailability and reducing oxidative stress. These findings provide further support for the idea that DSR has the potential to improve CV health and reduce the risk for CVD beyond its BP-lowering effects.
The authors thank Keri Nelson, Eric Chung, Elena Pellicer, Kate Howell, and the staff at the University of Colorado–Boulder CTRC, particularly bionutritionists Kathleen Farrell and Rebecca Staley, for their technical assistance.
For a an expanded Methods section, and supplemental table and figure, please see the online version of this article.
This work was supported by National Institutes of Health award nos. NIH AG013038, AG006537, AG03114, AG033994, AG03167, and TR000154. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Abbreviations and Acronyms
- tetrahydrobiopterin
- Clinical and Translational Research Center
- cardiovascular disease
- dietary sodium restriction
- endothelium-dependent dilation
- eNOS
- endothelial nitric oxide synthase
- FBFACh
- forearm blood flow to acetylcholine
- brachial artery flow-mediated dilation
- nitric oxide
- systolic blood pressure
- superoxide dismutase
- Received July 2, 2012.
- Revision received August 29, 2012.
- Accepted September 11, 2012.
- American College of Cardiology Foundation
- ↵
- Roger V.L.,
- Go A.S.,
- Lloyd-Jones D.M.,
- et al.
- ↵
- ↵
- Yeboah J.,
- Crouse J.R.,
- Hsu F.C.,
- Burke G.L.,
- Herrington D.M.
- Heitzer T.,
- Schlinzig T.,
- Krohn K.,
- Meinertz T.,
- Munzel T.
- ↵
- Celermajer D.S.,
- Sorensen K.E.,
- Spiegelhalter D.J.,
- Georgakopoulos D.,
- Robinson J.,
- Deanfield J.E.
- ↵
- Lakatta E.G.,
- Levy D.
- ↵
- ↵
- ↵
- Appel L.J.,
- Frohlich E.D.,
- Hall J.E.,
- et al.
- ↵
- ↵
- Dickinson K.M.,
- Clifton P.M.,
- Keogh J.B.
- ↵
- ↵
- Boegehold M.A.
- ↵
- Zhu J.,
- Mori T.,
- Huang T.,
- Lombard J.H.
- ↵
- Jablonski K.L.,
- Gates P.E.,
- Pierce G.L.,
- Seals D.R.
- ↵
- Nurkiewicz T.R.,
- Boegehold M.A.
- ↵
- ↵
- Ni Z.,
- Vaziri N.D.
- ↵
- ↵
- Seals D.R.,
- Tanaka H.,
- Clevenger C.M.,
- et al.
- Mancia G.,
- De Backer G.,
- Dominiczak A.,
- et al.
- ↵
- ↵
- ↵
- ↵
- US Dept of Agriculture ARS
- ↵
- ↵
- Landmesser U.,
- Merten R.,
- Spiekermann S.,
- Buttner K.,
- Drexler H.,
- Hornig B.
- ↵
- ↵
- Pierce G.L.,
- Lesniewski L.A.,
- Lawson B.R.,
- Beske S.D.,
- Seals D.R.
- ↵
- ↵
- Donato A.J.,
- Eskurza I.,
- Jablonski K.L.,
- Gano L.B.,
- Pierce G.L.,
- Seals D.R.
- ↵
- Dickinson K.M.,
- Keogh J.B.,
- Clifton P.M.
- ↵
- ↵
- Noguchi K.,
- Hamadate N.,
- Matsuzaki T.,
- et al.
- ↵
- ↵
- Mitchell G.F.,
- Hwang S.J.,
- Vasan R.S.,
- et al.
- ↵
- Donald A.E.,
- Halcox J.P.,
- Charakida M.,
- et al.
- Walsh J.H.,
- Bilsborough W.,
- Maiorana A.,
- et al.


text:
The Bridges at Warwick is owned and operated by Basile Senior Housing, a regional provider of quality personal care and memory care services that's dedicated to helping seniors lead dignified, purposeful and fulfilling lives.
The company began with owner Robert Basile's personal journey in trying to find quality senior living for his father. Since its inception, Basile Senior Housing has been successful in helping residents retain their independence for as long as possible.
The Bridges at Bent Creek was Basile Senior Housing's first community. Located in Mechanicsburg, Pa., The Bridges at Bent Creek also offers personal care and comprehensive memory care. It was at The Bridges at Bent Creek where the philosophy of 'Celebrated Senior Living' was born, nurtured and perfected.
Visit The Bridges at Bent Creek »
Basile Senior Housing is a division of The Basile Corporation, a highly reputable builder of exceptional residential and commercial properties in Southeastern Pennsylvania for over 25 years.
By integrating every aspect of the development, construction, management, sale and mortgage financing of real estate, the corporation creates superior housing opportunities. With its expertise and accountability, highly professional staff and strong financial resources, The Basile Corporation has earned a reputation as one of the area's leading home builders.
The Basile Corporation creates the most favorable living environments in distinctive residential communities of single family homes, townhomes, condominiums and apartments. Among the many prestigious communities developed are: The Ponds at Chesterbrook, Smith Farms in Wayne, Coventry Crossing in Glen Mills, Woodgate and Orchardbrook in Reading, Painters Crossing in Chadds Ford, The Meadows in Mont Clare, Prussian Woods in King of Prussia and the historical restoration of The Courts Apartments in Powelton Village, Philadelphia.
The Basile Corporation is the recipient of many local and national real estate awards. These include the prestigious Pillars of the Industry Award from the National Association of Home Builders, Pyramid Awards from the Home Builders Association of Chester and Delaware Counties and The Commerce Bank Tri-State Building Excellence Award.


text:
The many ways you can donate to our cause
Whether you actively say – "Here. I want you to have this." or in a more casual fashion by doing what you already do, the following are options for you to help supplement our financial bottom line.
- Active Donations (Your specific money or goods donation)
- Casual Donations (We can benefit when you do what you already do)
Ad-Hoc Requests (Current Needs List)
From time to time our programs have needs for donations of food, supplies, services, and equipment. We will post requests for these needs as they present themselves on this website and via social media.
Used items are fine, but we would like them to work. 🙂 Keep your ears open for neighbors, family, and coworkers that may have some of these items. Email Keith if you think you can help us with any of these. Thanks! email@example.com
Colorado Gives
Ascend Performing Arts was vetted and awarded a year to year grant by Community First Foundation to utilize ColoradoGives.org, a year round online giving website. ColoradoGives.org encourages charitable giving by providing comprehensive, objective and up to date information about 1,700 non-profits and provides an easy way to support Ascend Performing Arts. Click the button below to make a donation!
Also – Don't forget us on Colorado Gives Day to help us maximize the benefit of your donation.
Friends of Blue Knights
The Friends of Blue Knights program was originally established in 1998 to specifically help offset costs related to the activities of the drum corp. Although the Blue Knights have since developed the all encompassing Ascend Performing Arts organization to oversee programs other than just drum corps, Friends of Blue Knights is a means to direct your donation to the Blue Knights brand which includes BKDBC and BKPE.
Click here for complete information about the Friends of Blue Knights program or use the information below do make your donation.
Make your donation count at:
Or send a check to:
Friends of Blue Knights
3538 Peoria Street
Suite 500
Aurora,CO 80010
NOTE: Designate "Friends of Blue Knights" in the special instructions section when you make your donation.
Round-Up Your Change with Bstow
You can round-up your change on credit and debit purchases to go to Ascend Performing Arts by setting up an account with Bstow! Click HERE to set it up.
- Login and Choose a Charity: Search for "Ascend Performing Arts" in the list of available charities.
- Link Your Bank: Connect the accounts and cards you use to make everyday purchases.
- Donate Your Change: Use your credit or debit card anywhere. Bstow round-ups your purchases to the nearest dollar and gives the change to Ascend Performing Arts and the Blue Knights.
Or set-up your "round-up" with WeMicroGive.com:
United Way
The Blue Knights are eligible to receive funding from the United Way! If your company takes part in the United Way campaign, the Blue Knights will benefit by your naming the Blue Knights as the designated recipient of your donation. To do this, simply turn the card over, check the appropriate box, and write in:
The Blue Knights
3538 Peoria Street
Suite 500
Aurora, CO 80010
NOTE: To ensure proper credit, write the word "Optional" on the front of the pledge card.
Donate Your Car: Cars for Charity
The Blue Knights are now able to accept donations of automobiles, trucks, motorcycles, boats and recreational vehicles through Cars for Charity. Vehicles must have a clear title to be processed. Cars must be 1987 or newer and trucks 1979 or newer. Free towing is available – running or not. You receive free title services and a receipt for your tax-deductible gift. Click HERE to learn more about how you can donate your vehicle.
Shop at King Soopers (Neighborhood Rewards Card)
Ascend Performing Arts is pleased to announce a new way to support our programs simply by buying groceries! We are now offering King Soopers Neighborhood Rewards Cards in the BKMarketplace. King Soopers is a part of the Kroger family, so these reloadable rewards cards can be used nationwide at many popular grocery stores. (click here for a full list)
Every time you load up your card to purchase gas, prescriptions or groceries at participating stores, Ascend Performing Arts will receive 5% of the total amount back!
This is an easy way to make money for Ascend and your favorite ensembles, while doing something you'd be doing anyway—buying groceries!
- Simply purchase the card through our BKMarketplace online store, then take it with you the next time you go shopping.
- Prior to checking out, load the card with any amount (up to $500 at a time) and then use it to pay for your purchases.
- You can load your card at the Customer Service counter, but as there is a 5 minute delay for processing it's easiest to just ask your cashier to load it with your specified amount in a separate transaction before you buy your groceries.
That's all it takes to give back to Ascend Performing Arts! Purchase your card today, and start saving tomorrow.
For a detailed FAQ about our King Soopers Neighborhood Rewards Card Program and a list of participating stores, please click here.
Search the Internet with GoodSearch or Shop with GoodShop
GoodSearch is an internet search engine with a unique social mission which involves generously giving back to the Blue Knights with every web search. All you have to do is select "Drum and Bugle – Blue Knights". Click HERE to help Blue Knights and save as your browser home page.
If you believe in promoting teamwork, personal growth and education for our youth, then we have a perfect program for you! Once you sign-up and use the Goodshop shopping portal when buying goods and services at your favorite retail sites, Goodshop will donate to Ascend Performing Arts up to 20% of what you spend online. Your shopping habits don't need to change to raise funds – for free – for our organization. Whether you're buying fruit baskets from Harry & David, mounted wall art from Shutterfly or a diamond ankle bracelet from Zales you can save money using Goodshop coupons while raising funds for Ascend Performing Arts!
Shop On-line with Amazon Smile
AmazonSmile is a simple and automatic way for you to support our organization every time you shop at Amazon, at no cost to you. When you shop at smile.amazon.com, you'll find the exact same low prices, vast selection and convenient shopping experience as Amazon.com, with the added bonus that Amazon will donate a 0.5% of your purchase price to us. Click the button below or point your web browse to smile.amazon.com and add Ascend Performing Arts as you charity of choice.
Or click on the graphic below to set-up a plug-in that automatically takes you to Smile.Amazon.com each time you go shopping online:
Shop On-line with iGive
iGive.com is an on-line shopping mall. When you shop at iGive.com, up to 15% of your purchase price will be donated to the charitable cause of your choice. Just by registering as an iGive member, and designating the Blue Knights as your cause, the Blue Knights will earn money every time you visit iGive.com, whether you buy or not. The more you buy at iGive.com, the more money you raise for the Blue Knights! iGive.com provides categorized shopping in areas such as books & magazines, computers, fashion, kid & teen, music & video, toys & games, pets, automotive, and many more.
To begin earning money for the Blue Knights, visit iGive.com and click on the 'join now' button. Any information you provide during registration is kept strictly confidential, and will never be released or sold. Be sure to read the privacy statement. Choose the Blue Knights as your "cause", and the corps will earn money every time you visit iGive.com, and even more when you make a purchase. Make your first purchase within 45 days, and iGive.com will donate an additional $10 to the Blue Knights.
Click HERE now and start raising money for the Blue Knights today!
Giving Assistant
With Giving Assistant, your purchases at 1,800+ popular online retailers have the power to support our mission by helping us go further, and do more. It's free! When you earn cash back using their platform, you can also choose to donate a percentage of those earnings to Ascend Performing Arts. It's like changing the world with every purchase. Make your first donation using Giving Assistant today, and get first dibs on deals like JCPenny Coupons, in addition to cash back donations at places like eBay and Best Buy! Click here to start supporting Ascend through online shopping with Giving Assistant.
Never miss a cash back opportunity. You could be earning more cash back. Download the Giving Assistant button and you'll be notified when you're visiting a participating retailer's site of 500+ participating stores—from Macy's to Walmart—you'll literally never miss another cash back opportunity. Earn the most cash back. Grow your earnings faster. Available now for Chrome and Safari.
Do you love your pet like a member of your family? Of course you do. HomeoAnimal is made up of a group of animal lovers and pet advocates. Ascend Performing Arts receives a 20% commission on HomeoAnimal purchases through this link!
We're aware that "traditional" methods of medical intervention are sometimes necessary. But we also know that these methods are not the only option. And although there are a myriad of traditional "pet meds" sites on the web, good information on homeopathic remedies seems to be lacking. When you become a HomeoAnimal customer, we consider you as part of our extended family.


text:
Bingo Cove
Bingo Cove
Enjoy some sun, sea, sand and bingo with Bingo Cove. Transport yourself to bingo paradise with this site that offers fantastic promotions and bonuses. As they are brought to you by Dragonfish, and have teamed up with some of the leading software providers in the industry, you can also rest assured they have a top games selection.
Key Features
The main attraction of Bingo Cove is their brand new welcome offer. As soon as you make your first deposit – you will be treated to a 200% welcome bonus to spend on there mobile bingo site, and another 200% welcome bonus to spend on slot games giving you the best of both worlds! All you need to do is make a deposit of at least £10 to qualify. As an additional incentive of 3 whole days of free bingo sessions in their Quids In Room. Here you can play as much as you want without having to spend a penny.
Bingo Cove Offers
- 1 st Deposit – 100% up to £100
- 25% Cashback on the casino games
- Casino game of day
- Pay by phone bill
- Bonus features
Terms & condition apply *see site
Claim Your Bonus at Bingo Cove!
On top of this there are loads of other staple promotions such as Happy Hours where you can take advantage of re-deposit bonuses, pub quizzes and more, Sure Win games where you are guaranteed to win a prize, Spin-Tastic where you can play bingo for free spins, the Weekender where there are lots of guaranteed jackpots for the taking – and a fantastic loyalty scheme where you can earn all kinds of rewards just by playing on their site.
In terms of games – there are lots of them! There are 3 different kinds of bingo which are 90 ball bingo, 75 ball bingo and High 5 bingo where there are 5 chances to win. you will also find guaranteed jackpot bingo games, and progressive jackpots. You will be spoilt for choice when it comes to slots. Spin on the likes of Fluffy Favourites, Temple of Isis, Sugar Train, Shamans Dream, Jack and the Beanstalk as well as many more. They also have a handful of scratch cards and table games to check out too.
Help is always available at Bingo Cove, so if you ever need any assistance – you can check out their FAQ section where you will find the most common queries, you can drop them an email – or else you can use instant live help for an immediate response, they also have pay by mobile option for all players
Our Conclusion
With a huge welcome package waiting for you, a flurry of games, and top notch promotions – Bingo Cove doesn't leave you wanting for anything!
Comments are closed.


text:
A beer company has come to the rescue of Jamaica's troubled women's bobsleigh team by donating a sled, an official told AFP on Friday -- the eve of their Olympic debut.
Jamaican brewer Red Stripe pitched in after Jamaica's coach Sandra Kiriasis left the team this week and was reportedly demanding payment for use of their existing sled.
The intervention means Jamaica's women can make their fairytale debut in the Games, 30 years after Jamaica's "Cool Runnings" men's team competed at Calgary 1988.
They will take part in their first official training heats on Saturday at the Olympic Sliding Centre, a 1,376m ice chute in the South Korean mountains.
Red Stripe made their initial offer on Twitter, and then clarified that "this is not a joke".
"The Games are an honor to compete in, and as the No.1 beer in Jamaica we want to help those athletes realize their dreams," a statement said.
Kathleen Pulito, spokeswoman for the Jamaican team, told AFP that the sled donation was genuine.
It has been a rollercoaster journey for Jamaica's Carrie Russell and Jazmine Fenlator-Victorian, who competed for the US at Sochi 2014 and was in tears last week as she described her joy at being a role model for black children.


text:
[wc_row][wc_column size="one-half" position="first"]
[/wc_column][wc_column size="one-half" position="last"]
At the beginning of the year, I began a one-year detox; meaning no gluten, no refined sugar and no dairy products. Now, one month into my personal health project, I´m beginning to harvest the benefits and I feel super happy with my decision.
A few days ago, someone wrote to me "I feel so sorry for you, that you will not be able to eat cake all year". But here´s the thing; living a healthy lifestyle does not mean, that you can never enjoy the good stuff like cake. It´s all about choosing the right ingredients and be aware of what type of food you put in your body.
[wc_row][wc_column size="one-third" position="first"]
[/wc_column][wc_column size="one-third"]
[/wc_column][wc_column size="one-third" position="last"]
Today I´m sharing my favorite cake recipe; a delicious pie with dark chocolate and fresh berries. I would not call it a healthy cake – but it´s not unhealthy either. It´s a treat that is perfect for someone living a life free of gluten.
I believe the key to a healthy lifestyle is not to be fanatic, but to listen to your body and treat it with respect. That´s what I´m trying to do and it also includes that occasional glass of red wine and a few pieces of dark chocolate now and then.
Gluten Free, No Bake Chocolate Pie
Serving: 4-6 persons
A small handful of almonds
3-4 stone-free dates
1 spoon of raisins
2-3 spoons raw coconut oil, melted
1 cup coconut flour
1 tsp organic lemon juice
If needed stir in water just enough to hold the mixture together
Dark chocolate 70% or more, melted
A cup of mixed berries
[wc_row][wc_column size="one-half" position="first"]
[/wc_column][wc_column size="one-half" position="last"]
Mix all the ingredients for the crust in a food processor or a Vitamix blender. Blend the dry ingredients first and then add the rest. Use a spoon to get all the dough out of the mixer.
Squeeze the mixture into the pie plate, spreading the filling out evenly and let it chill in the refrigerator for a few hours. I like to make the pie crust in the evening and then I let it rest overnight, but two hours should be enough for it to cool.
For the topping add dark chocolate in a heat-proof bowl, place it in a thick-bottomed sauce pan with water. Melt the chocolate over high heat and then spread it evenly over the pie crust. Finally add a good handful of berries and enjoy!
Have a fabulous day,


text:
Wednesday, May 1, 2013
3 Month Anniversary!
Posted by Kristen at 11:01 AM
Labels: Heaven is Here, Nie Nie, Patience, Surgery
3 comments:
- Kendrick and Desiree said...
I'm sorry Kristen! There is nothing worse than feeling stuck, like you aren't progressing no matter how hard you try. I've been through my own version of being stuck and wanting to hide from the world. I miss you and I think you are AMAZING. I know you will be back to normal eventually and then you will look back on this time and be so proud of yourself for making it through. Because you are THAT amazing.
- May 1, 2013 at 12:02 PM
- Anonymous said...
love you...take as long as you need. Soon it will be summer and we will sit by the pool and sip something sweet watching our kids play.
(I can't remember my log in...and the pain meds kicked in! Its my back....again!!!!)
- May 6, 2013 at 10:40 PM
- Heidi Totten said...
I think you should take all of the time you need and you certainly don't need to answer to anyone! There is definitely a post traumatic stress issue with any major surgery. I certainly had it for six months after my first c-section. Big hugs!
- May 7, 2013 at 11:46 PM


text:
Merry Christmas...
1 day ago
This is beautiful, Val! LOVE that image and the soft colors are amazing! A perfect card. :) I hope you have time to play along with us at Inkspirational for our color challenge and at Technique Tuesday for our 3D Pop-Up Card challenge!!! We've got prizes and giveaways going on! HUGS!!! :)
People ah, you kind of sad for you to find remedies in your own way, that would be in vain. You can reach all of the light is merely recognize the truth or you will never find better in your own being.
I like: RS Gold and Cheap RS Gold


text:
Capacity-Building program closed 5/31/2019.
Get information on upcoming grant opportunities.
Learn More
Hi'ilei Aloha LLC is a non-profit subentity of the Office of Hawaiian Affairs (OHA), a state agency formed through the State Constitutional Convention in 1978. Hi'ilei Aloha's mission is to identify, promote, develop, and support culturally-appropriate, sustainable opportunities that benefit Native Hawaiians. LEARN MORE »
Hi΄ilei Aloha LLC
Pacific Park Plaza
711 Kapi'olani Boulevard, Suite 111
Honolulu, Hawai'i 96813
Telephone: (808) 596-8990
Fax: (808) 596-8992
Email Us


text:
La locanda Oceano Mare bed&breakfast
Locanda Oceano mare is open from 25 march
Oceanomare Inn is situated in the Rimigliano Park, 7 km's south of San Vincenzo (LI). It's a tipical old tuscan farm of the end of the XVIII century, completely restaured in 2000 respecting the original structure. The Inn is surrounded by a 4500 square meter lawn and it is inside a 10 km pinewood that runs behind the coast between the Baratti Gulf and San Vincenzo. The Inn is few steps from a 10 km long sandy beach which is open to the public and not very crowded, even during the summer. A few km's southwards there is Populonia, a small medieval walled village of etruscan origins with a wonderful view over the sea and Elba Island. In other words, a holiday among nature, relaxing and cultural.
The bed and breakfas has a restaurant with 80 seats inside and 80 outside undercover. On the first floor, reachable by exterior stairs and an elevator, there are six rooms, each with private bathroom, that can host up to 12 people.


text:
by Raul Menchaca
HAVANA Marc-Andre Fleury Golden Knights Jersey , Sept. 24 (Xinhua) -- Nayvis Diaz does not regret selling her Peugeot car to finance the opening of her bicycle repair and rental shop in Havana, three years ago.
Now, seven women work in VeloCuba, which Diaz opened after leaving her job at the Ministry of Foreign Trade to take advantage of Cuba's economic reforms.
VeloCuba's beginnings in September 2014 were not easy but its owner did not give up and took charge of everything: the workshop, accounting, even distributing advertising flyers.
"I did it absolutely all. One of our employees used to be a professional cyclist and she brought all the technical knowledge on fixing a bike James Neal Golden Knights Jersey ," she told Xinhua.
Accompanied by Dayli Carvo, a former national cycling team member, Diaz has helped cycling stand out in Havana.
As advertising opportunities are extremely limited in Cuba, Diaz's clientele was built up through word of mouth, including the fact that only women are employed in the workshop.
"The objective is to empower women in different activities they seemingly cannot do," explained Diaz.
VeloCuba saw rapid success and Authentic Tomas Tatar Jersey , after a year, it expanded to offer rentals, road repairs, servicing at home and offering five bicycle tours through the capital. Guides on these tours can offer them in Spanish, English, German and French.
"We place great emphasis on knowing historical matters. We are very keen for our visitors to discover architecture Authentic Alex Tuch Jersey , art, new places they can go at night, and learn about Cuban society," said Diaz.
Now, VeloCuba has two workshops, one in the central neighborhood of Vedado and another in Old Havana Authentic Nate Schmidt Jersey , among the city's busiest districts.
The lack of a large-scale market for bicycles is the main problem of VeloCuba, which has had to buy bicycles from foreign tourists visiting the island.
However, as a service to the community, the workshops repair and maintain wheelchairs for free.
"It is our way, as a company, to offer some help to society Authentic Jonathan Marchessault Jersey ," said Diaz.
VeloCuba has a coordinated partnership with Cuba's sports authorities to establish activities for children, including cycling.
"I dream that, on one or two days a week, only cycling is allowed in the city," Diaz said with a smile.
Albanian version of Chinese president's book on governance launched in Tirana
Opening ceremony held for 2017 WTA Wuhan Open
Bubble run held to celebrate National Day in N China
Kazak Autonomous County develops eco-tourism in China's Xinjiang
Autumn scenery of Kanas scenic area in NW China's Xinjiang
Chinese, Pakistani air forces conduct joint drill
Paddy cultivation area in China's Yanbian surpasses 46 Authentic Brad Hunt Jersey ,000 hectares
China Focus: Beijing-Shanghai railway speed rises to 350 kph
Drug possession criminal charges can easily differ significantly, dependant upon the quantity of the drug you're charged with possessing. Even a minute quantity of illegal drugs can easily come with severe consequences and the fees and penalties just get much more serious as the quantity increases. Try to remember to think long term; you would like the criminal case handled correctly today to ensure that it will be considered a speed bump instead of a road block in your life. The Recommended Houston Criminal Lawyer is going to be dedicated to that type of defense.
Laws regarding Drug Possession frequently prosecute drug offenders in very much the equivalent manner they prosecute various other felony offenders. Approximately 90 % of all the drug possession cases will not make it to trial. The majority of the offenders will plead guilty to drug possession violations. A basic drug possession conviction in Texas might lead to community service, probation, drivers license sanctions, court-ordered drug rehab, county jail time and fines.
A few police forces obtain restitution for their expenses in connection with the criminal arrest and prosecution. Even though the seriousness of the penalties differs with the criminal offense Authentic William Karlsson Jersey , a good number of drug criminal charges in Texas have significant consequences of some sort. This is often particularly accurate when the charged offense entails weapons in "protected zones" (like educational facilities and recreational areas), adolescents, or perhaps a past drug conviction. Criminal defendants looking to steer clear of prison or jail will want to get in touch with an experienced drug defense lawyer early on in their case.
Laws regarding Drug Possession are frequently more severe for possession of drugs which have a higher propensity to trigger misuse, dependency, physical injury, and loss of life. Laws regarding Drug Possession also make it a criminal offense to possess any sort of precursors to drug production or distribution. Possession of paraphernalia Authentic David Perron Jersey , or drug accessories, is also unlawful according to laws regarding drug possession.
Laws regarding Drug Possession are also more severe in instances when an offender was caught with a significant amount of a given substance. Frequently Prosecutors will charge these offenders with "drug possession with intent to distribute". In these instances, an offender might have to deal with an enhanced sentence with more severe penalties. Drug possessions laws also prosecute multiple offenders considerably tougher than those that are first time offenders.
Don't risk a potentially life-ending conclusion to your case. Get in touch with the Best Houston Criminal Defense Lawyer now. In drug possession defense criminal cases, the Best Houston Criminal Defense Attorney will work to prevent the case from becoming charged as drug distribution, that carries a lot more severe penalties. This individual will conduct a thorough investigation into law enforcement procedures, looking for evidence of constitutional misconduct which will permit him to file motions to dismiss pa. Cheap Jerseys Cheap Jerseys Cheap Jerseys Cheap China Jerseys Cheap Jerseys China Free Shipping Cheap Jerseys From China Wholesale Authentic Jerseys Cheap Alternate Jerseys Wholesale Hats China Wholesale Hats China


text:
Laparoscopic Surgery for Digestive Cancers:
Digestive cancer means tumor present in one or many of the digestive organs in our gastro-intestinal tract.
Digestive organs include esophagus, stomach, liver, spleen, gall bladder, pancreas, small intestine, large intestine and rectum.
One of the biggest limitations of open surgery is that the surgeon has to make a big incision of 6-9 inches on abdomen even to access affected area and many a times realize once accessed that the disease is too widespread to operate and simply close the abdomen.
Diagnostic, Staging and Therapeutic Laparoscopy offers a great advantage in avoiding such morbid exploration in cases of stomach, colon and pancreatic cancers.
There are enough large randomized controlled trials (RCT) to prove that laparoscopic colonic resection is comparable to open surgery in terms of disease control and recurrence.
Even laparoscopic liver surgeries are done for cancer of liver in dedicated centers with excellent results.
With the advent of new technology, skills and experience the conversion to open surgery is considerably reduced.


text:
Project timeline
Here's the plan for this spring:
Jan 14: Introductions and post-it note meeting
Feb 1: CMS overview and selection
Feb 8: Design version 1, database layout conversation, install Codeigniter
Feb 15: Design version 2, database layout conversation
Feb 22: Design version 3
Feb 23: Start to build database with Sequel Pro
Feb 26: Complete database design and complete database
Mar 1: Design version 4, begin coding frontend: start creating the pages with Codeigniter
Mar 15: Design version 5, markup and add data for testing
Mar 18: Database table and data conversation
Mar 22: Marking up site in XHTML/CSS and connecting Codeigniter
Mar 25: Working out details of application form, discussion XHTML/CSS markup issues
Mar 29: Working on community member page, other XHTML/CSS markup issues
Mar 30: Design coded in XHTML/CSS, begin creating dashboard for administration
April 5: Frontend should be pulling all data from backend, begin browser/OS testing and validation
April 8: Discuss administrative dashboard and application process
April 12: Continue work on admin dashboard, tags for artists pages
April 15: Conclude admin dashboard, begin work on member dashboard, discuss procedure for uploading files
April 19: Continue coding member dashboard
April 22: Complete member dashboard, go live date for Beta site, begin member/user-data testing.
May 15: Conclude all member testing, begin making changes based on feedback
May ?: Stage 1 jquery additions
May 22: Go live date. Celebrate successful project!
Comments Off on Project timeline
Frontend Design – Version Discussion
VERSION 2 Improvements
- Pull some work/information from the old site
- Use standard ad sizes to place under Spotlight News
- Huge image on top (2 columns)
- No color, only one for hotlink
- Incorporate Georgia font into site, sans-serif for small text
- JQuery slider for featured artists?
- Truck only logo
- Controller nav (What's New, Login, Search) + basic website nav (About, Apply, Artists, Support)
- Facebook + Twitter icons/link
- No friends
- "Follow" + "Share" on every page
Member Page
- Rename Guestbook to something else (make it a JQuery form to send messages)
- Big image for member page
- Avatar = most recent work (no actual images of person)
- Include their news feed, recent activity, and "Guestbook"
- No bio, just an Artist Statement that's short or has a "Read More" option
Website Designs
VERSION 2 Progress
- I found a nice website that might be similar to what we want to achieve with YAH: http://mesa.cityofgrace.com/ It has a very nice image scroller (but made with Flash) under the basic navigation and a very nice calendar below it. The footer also looks very professional and clean.
- Standard web ad sizes are located here: http://www.iab.net/iab_products_and_industry_services/1421/1443/1452 At the bottom of the webpage, there are various sizes of rectangles, banners, buttons, and skyscrapers.
- "Guestbook" can be renamed to "Contact"?
- Pictures from artists are hard to come by on the old YAH site….
- The Homepage design will be posted once Chris is done with it. Here is what I gave him to play with anyways:
Post-it Conversation
I. Homepage
- Database stats (examples of features, usage, etc)
- Top 10 most visited artists
- Event, Announcement, News Blog (paid service for companies)
- Recent members
- Explanation/mission statement
- Hosting plan
- Featured artist (random or based on something, archive)
- Latest artworks (thumbnails, showcase)
- Large artist image?
- What's new? box (members contribute to News feed)*
- News/member feed (announcement title, artist name, date; separate URL for each post, flag, Digg/Delicious, Tweet)
- News ticker (site news, member activity, etc)
- email subscription signup
- search box
- calendar (iCal, Google Calendar integration?)
- Suggested artist websites that member may like (based on tags?)*
- Links to other social networks (placed with news feed widget?)
II. Navbar
- Logo
- Apply (check for username availability, password security)
- User's login
- Call for artist section
- About
- Widget for news feed (for social networks or general/personal websites)
- Support/knowledgebase (login, share what you know about hosting, FAQ forum/blog?, open so non-members can post/comment)
III. Misc
- Mobile site?
- Member pages
- Member control panel
- Project collaboration/discussion groups? (groups and solo artists)
* denotes logged in
Comments Off on Post-it Conversation
A little history and list of possible features for the new yourarthere.net website
yourarthere.net is a web hosting consortium for artists/designers, art organizations, and activists I created in 2004 while a director of Your Art Here.
The original plan, was that in addition to the very low costs, personal support, and feel-good non-profit nature, the yourarthere.net website would network artists by providing not only links to members of the yourarthere.net community, but also by featuring one artist or group each month on the website with an image and link to the member's website. Unfortunately, this turned-out to be more work than expected for one person.
So, the goal of our project is to redesign the yourarthere.net site to make it and the organization as sustainable as possible. I've listed important results to consider below.
- The main goal is to make the yourarthere.net project sustainable. Here are some things I think will help that:
- Feature artists and galleries on the website.
- All news and arts content will be user-generated.
- Email announcements will be automated.
- Consider carrying advertisements on the website. See: e-flux.com
- What should we do to make yourarthere.net more competitive (better hosting plans, support, etc.)?
- Add an easy-to-use CMS like indexhibit.org for artist websites.
- How to make payments easier? (currently set-up as PayPal subscriptions but if user's cc changes it breaks the subscription, and we have to set it up again.)
List any possible features you can think of in the comments!
- Login section for members
- Member pages that they can update
- Member news that appears on 1. their page and 2. a public feed on the yourarthere.net home page
- Calendar of events (list or calendar view on Home page)


text:
The man credited with building the first Hindu temple in America — per direction, in a city beginning with the letter "n" — passed away last month. Alagappa Alagappan was 88.
The New York Times has the obituary:
In 1968, on a trip to his native India, Alagappa Alagappan dreamed that an ancient Hindu god told him to visit a medium. So he did, and on his first visit the medium read palm leaves to tell him that the Lord Ganesha — another deity, this one beloved for his laugh and his elephant head — wanted to settle in a city beginning with the letter N.
On the medium's instruction, by his account, Mr. Alagappan returned the next day, and he learned that Ganesha had asked for more: He wanted temples to be established throughout North America. On the third day, the medium told Mr. Alagappan that it was his job to arrange that. So he did.
Today there are 700 Hindu temples in the United States, serving a Hindu population that since 1965 has increased thirtyfold, to about 1.5 million.
Mr. Alagappan started the project close to home, in his adopted city whose name began with N.
"With nothing but faith, I began the task of getting a temple built in New York," Mr. Alagappan told Madras Musings, a newspaper published in Chennai, India, in 1998.
Meeting in his living room, he and others, some of them also United Nations officials, formed a planning group with the aim of making the increasing number of immigrants from India feel at home in their new country. In 1970 they founded the Hindu Temple Society of North America.
It sounds like he lived a varied life: admitted to the British bar, serving with the UN, working as a reporter.
Posted by Steve


text:
Digital Depression
Information Technology and Economic Crisis
University of Illinois Press, 2014
"Drawing on excellent research across a range of fields, [Schiller] provides the best book-length treatment of digital capitalism in the wake of the worldwide economic crisis that erupted in 2008 and offers the best map of the digital communications industry in current scholarship."– Vincent Mosco, author of To the Cloud: Big Data in a Turbulent World.
"Far-reaching as an empirical study of contemporary political economy and far-sighted as a social-scientific interpretation of a complex and contradictory reality. Extremely stimulating and important."– Richard Maxwell, co-author of Greening the Media
"It is not possible in this short review to do justice to the content of the book. It must suffice to say that it starts by tracing the origins and consequences of the current financial and economic crises, and their significant relation with ICTs; the increasing importance of trans-national production and corporations; the effects of ICTs on the military, the production and use of networks, end-user hardware, and software." — Richard Hill, an independent consultant in Geneva who was formerly a senior staff member at the UN International Telecommunication Union (ITU).


text:
Recently Microsoft has been testing new features including one that will allow users on their mobile devices to enter an Xbox Live Party Chat via the Xbox app on their phone.
This well prove useful to play cross-platform games like Minecraft Better together, or for those who dont have a mic for their Xbox.
If you want to try this out all you have to do is Download the Xbox Beta app on the android marketplace. No official iPhone release date as this information came from a Reddit user who noticed some changes in the betas app patch notes.