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Kermies Q&A with Ed Eminson
ED Eminson is a lover of Brockway, a truck that has sadly passed into history.
Kermie: Nice truck Ed. That bright orange paint job matches your ruddy cheeks.
Ed: Beautiful isn't she?
K: Not a truck we see every day. What sparked your interest in Brockway?
Ed: Started back in the 90s. I bought a couple of 1930 models. I had a truck encyclopaedia which said Mack bought them in 1956. I rang Mack to get more info but they weren't interested so I checked out the internet. This was in 2000 and the town of Cortland, USA was holding the first ever Brockway truck show. I couldn't resist so I hopped on a plane to have a look see and find out more about the brand. I went into a shop that had the Brockway emblem - a Husky - and was amazed that the owner knew who I was. Turned out that my wife had been in touch with the Brockway committee and the whole town knew that a nutcase Aussie was coming from the other side of the world to see their 'little' truck show.
K: And that's where you came across this beast?
Ed: Yep. There were 100 trucks on display and this stood out like the proverbials. He's a 1975 F761TL with a 475hp 8V92 Detroit under the bonnet.
K: So you bought him then and there?
Ed: I wish. I went back to the show every year for the next seven years and in 2007 I was told he was for sale. I rang my wife, Amanda, back in Oz and asked her what her favourite colour was. With her bright orange hair I knew what the answer would be.
"Orange," she snapped. "And it's 3am!"
Told her I'd bought her a present to match her hair. She said, "Terrific. Now can I go back to sleep?"
Cutting to the chase, I eventually got him back to Oz. Took a hell of a lot of money, time and grief but was worth all the effort.
K: Most people I speak to refer to their trucks as 'her'. You call the Brockway 'him'.
Ed: He's called 'Bruiser'. Ever heard a girl called that?
K: Fair call. So what about the history of the brand?
Ed: The company started in 1912 and went until 1977 when Mack closed it down. They were hand-made to customers' requirements. A big truck in their day, they were popular for interstate, off-highway use and for snow ploughing. There's still plenty operating in the States today. They also had a good slice of the Australian market in the 1920s and 30s. They were the most rugged truck in the world and that Husky emblem typifies the brand. Huskies can beat the crap out of any old bulldog.
K: Happy driving Ed.
Ed: Every time I'm behind the wheel Kermie.


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Aluminium Aussie Non-Slip Ruler
Excl. GST
Non-slip saftey ruler. The raised centre of the ruler helps to reduce the chance of knife cuts due to knife slippage. 300mm-2500mm in length
Product Description
This solid, anodised aluminium safety ruler has a raised handle, full-width rubber base, and clear, legible measurement marks
Technical Information

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Warranty five (5) times longer
than other sellers
Delivery Deal
For a limited time enjoy a flat delivery of fee of $49.95* (site wide) to most SYDNEY, MELBOURNE and BRISBANE Metro areas.
This offer applies to the following postcodes:
- Sydney: 2000 - 2224
- Melbourne: 3000 - 3207
- Brisbane: 4000 - 4207
* This is a standard delivery service for retail customers and excludes large bulky or commercial orders. Excludes Tulip Marble Tables.
Handmade from the finest materials with a solid FSC® certified hardwood timber frame and polyurethane injected 'Memory Foam' with Dacron Silk wadding and topper layers, it is upholstered in a choice of 100% full-grain Italian Aniline Leathers with ornately carved legs in Natural or Walnut finish.
This splendid Chesterfield Armchair comes with a Five (5) Year Warranty free of additional charge.
View our full range of Replica Furniture. See why we offer the Highest Quality Replicas.
Specifications and Dimensions
Main Materials
Pure Italian Aniline Leather (Full-Grain)
Waxed Italian Aniline Leather (Full-Grain)
Other Materials
Solid Hardwood frame
PU injected 'Memory Foam' + Dacron Silk wadding
Premium Italian Lacquer in soft finish for UV protection
Key points
- 100% Leather on all surfaces
- Highly accurate reproduction
- Made by Hand
- 5 Year Warranty
Highest quality replica furniture
- Armchair: (W) 124 x (D) 90 x (H) 74 cm
- 2 Seater: (W) 186 x (D) 90 x (H) 74 cm
- 3 Seater: (W) 230 x (D) 90 x (H) 74 cm
All dimensions are approximate
Care Instructions
Our Materials
Our materials maintain the integrity of the original designs, lending authenticity to look and feel.
From thick European hides and luxurious pure wools to premium American hardwood timbers, British Stainless Steels and superior marbles.
We offer a full material range, so you can choose from a rich spectrum of fabric, leather and timber options. No other Australian replica seller offers a wider range of colours or materials.
This product is offered in the materials listed below.
Pure Leather (Italian Aniline Leather)
Super soft and supple, Aniline Leather is also durable and will age beautifully, developing its own unique personality with use.
Italian Aniline Leather is vastly superior to Semi-Aniline or so called 'Italian Leather', which are corrected top-grain leathers with artificially embossed grains and synthetic coating. Italian Aniline is warmer to the touch and will give a beautiful leather smell.
Waxed Leather (Waxed Aniline Leather)
Soft yet hardy, Waxed Aniline Leather is very durable and will age beautifully, developing its own unique personality with use.
Waxed Anilines are available in an earthy range of Tans, Brown and Olive.
Individual product pages will specify which hardwoods and finishes are available. As a broad guide, American Ash, Oak and American Walnut hardwood timbers are offered, with Ash being available in Natural, Walnut or Black finishes.
Memory Foam + Topper Layers
Topper layers of Dacron Silk ('Doll Cotton') and/or multi-density foam are used to provide additional comfort and shape for superior enjoyment, durability and aesthetic.
Website Reviews
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In the footsteps of bestsellers Where Chefs Eat and Where to Eat Pizza - where the best bartenders go for the best drinks
Where Bartenders Drink is THE insider's guide. The best 300 expert drink-makers share their secrets - 750 spots spread across 60 countries - revealing where they go for a drink throughout the world when they're off-duty. Venues range from late-night establishments and legendary hotel bars to cosy neighbourhood 'locals' - and in some surprising locales. The 750 expert recommendations come with insightful reviews, key information, specially commissioned maps, and an easy-to-navigate geographical organization. It's the only guide you need to ensure that you get the best drinks in the most memorable global locations.
Format: Hardback
Size: 203 x 137 mm (8 x 5 3/8 in)
Pages: 420 pp
Illustrations: 15 illustrations
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Our Company
Business Services
TurboChyll Energy Products
Market Applications
Guiding Principles
ChillerWorks Knowledge Center
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Turbines Our Way
Contact Us!
What's Spinning Lately!
"I would take the opportunity to give credit to Vito Costanza and Dominic DiDonna for their commitment to excellence in service and (to the) training they give to their staff." ~ Mr. Joseph Dagro-Chief Engineer, Murray Hill Properties
Industrial Cooling Inc. and their multi-owner clients prepare for a combined 8,200 plus tons of CFC RETROFIT PROJECTS to Environmentally Acceptable 134a/123 gases, representing seven large open and hermetic appliances as well as single R500 unit this shutdown season.
We then implemented a multi-year energy offering for their TURBOCHYLL LEEF Control System. After evaluating many packages and references of previous ICACS installs, Industrial Coolings TURBOCHYLL LEEF was the obvious selection of choice. Here too, they met every expectation in time and performance as well as spot on with our budget. Perhaps mostly is that the performance in our Chillers safety, operational and energy use has met and achieved every expectation and promise they made! ~ Michael Aisner, RPA, LEED AP, Building Manager, RXR Property Management LLC
Industrial Cooling selected by MERCK Pharmaceutical Pa. to perform multi-unit complex in frame overhaul of Large Multi Stage Condensing Turbine internal NDE Inspections.
"...I cannot speak highly enough of Industrial Coolings knowledge, professionalism and overall attention to detail for my entire project. I cannot recommend highly enough" ~ Mr. Chris Gaudan, Engineering, Merck & Co. Inc., Lansdale PA
ICACS successfully retrofits and commissions ACCUTRAK EGS Governor to large frame 3.4K-BHP Elliot Condensing Steam Turbine finding safety, convenience and efficiency to operation not afforded previously.
Municipal Energy and Utility Provider conducts evaluation of TURBOCHYLL LEEF Control System stating we were very impressed by the energy savings they achieved and further conclude; integration of these Control Systems into an existing chiller plant in a building can result in a reduction of steam usage of up to 30%...with a simply payback of 1-3 years in most cases
Industrial Cooling Inc successfully installs TurboChyll Min-E Electric Chiller Control System as part of multi year chiller modernization plan.
"Industrial Cooling is one of the most innovative companies I've worked with. The Company and VP Dominic DiDonna understands the technology behind ifm instrumentation equally as well as our engineers. Due to the collaboration between ifm and Industrial Cooling we've developed new components that we now sell to all our customers." ~ Chad Mosier, Industry Specialist, ifm efector
ICACS Completes quarterly OSHA 10 Training at 100% inclusion to all field staff and maintaining 3 yr Experience Modification Rate below 1.00.
Industrial Cooling Inc. hosts Employee "Labor Day LOBSTER BAKE" and cookout!
"our steam usage was substantially lower this month compared to the same time last year (2296 Mlbs /779 Mlbs). After a thorough investigation (of meter by Utility Provider) they concluded that everything was in good working order. I than informed them that the only difference from last year to this year is that we installed TURBOCHYLL LEEF energy efficient control panels on our steam turbines." ~ Mr. Ron Damato, Chief Engineer, York OMS 2200 Ton Chiller, 1185 Avenue of America
Industrial Cooling Inc. rolls out "Stand alone" TurboChyll Products for both electric and steam chiller applications.
"With the cost of utilities equaling up to nearly 37% of our budget costs, we have noticed based on historical utility trends that our usage is considerably down this year. We seem to be trending an overall steam reduction over 30%. We are achieving a much better and tighter target to set point which follows us to optimize higher efficiencies Your Staff did a neat and impeccable job." ~ Andrew S. Rothman, V.P., National Engineering Director, Jones Lang LaSalle, NY NY
Industrial Cooling Inc receives USPTO Trademark Registration 4,128,121 For its TurboChyll LEEF Steam Turbine Chiller Optimization System.
"As you know, installing a panel like the LEEF on a nearly 50 year old Worthington Compressor with a Murray Turbine has its challenge. As a result, the panel is much easier on us, the operators, and the machine is running as if it were brand new." ~ Brendan Murphy, C.E., Fisher Brothers, 605 Third Ave, NY NY
Pfizer Pharmaceutical New York Headquarters selects Industrial Cooling Inc and The TurboChyll LEEF for the Multi Year Steam Turbine Optimization Plan of choice...
"This is our second season utilizing the TurboChyll Leef Panel on our Steam driven York machine. Last year we saw a significant savings in our steam usage as compared to previous years. Everything you need to know about the machine is a finger touch away making the operation of the machine very efficient. We cannot wait for our sister machine to be modified." ~ Robert Delorenzo, Chief Engineer, SL Green Realty NY NY
NE Petro-Research Co. selects Industrial Cooling Inc and The TurboChyll LEEF for the Steam Turbine Optimization System of choice in their New Jersey Research and Engineering Company
"We are pleased with the operation of the TurboChyll LEEF package... It has greatly reduced our steam consumption, down time with control problems (such as) surges we had experienced in the past." ~ John Vasilakos, C.E., 485 Lexington, NY NY
Industrial Cooling hosts Field Service Appreciation Day in Cheeca Lodge, Islamorada Florida!
"This is the second Season we are operating the Chiller Plant with the LEEF Panel. The overall system is extremely user friendly allowing my Engineering Staff to change set points. There are detailed graphics that allow a better overview of each specific system operating via the LEEF panel. The LEEF panel is easily upgraded to allow additional applications." ~ Steve Gallagher, Chief Engineer, The Chanin Building, NY NY
Industrial Cooling Inc. receives USPTO Reg. No. 4,262,473 Int. CL:37, December 18, 2012 for Trademark Brand, our energy. your future ICACS believes that the future of Global Industry includes the responsible management of our energy resources. As new manufactured product becomes more challenging to installed value, contemporary energy products will be paramount to the Aftermarket Service and Support of large installed machinery and its complex applications. Considering innovative performance solutions rather than assuming historic replacement parts will be the commonplace to tomorrows energy leaders and performance minded users. our energy. your future is our commitment, as a leading Service Provider to this effort.
ICACS Releases "TURBOCHYLL LEEF /MIN-e TRAINING SCHEDULE-Introduction, Architecture & Set-Up". Please see our training section for online enrollment.
You (Industrial Cooling) set the bench mark for the rest and improve your craft year after year, thanks for taking us on the journey with you Adam D Fuller Project Development Manager , Dresser Rand Services Mid Atlantic Region
"In my 43 years in this business (37 years as chief) I have not met another service firm in this unique business, that provides the service, knowledge, and support as you do for us at all of our SL Green locations." ~ Mr. John Vasilakos -Chief Engineer, SL Green
"I would like to mention to you, that your technicians, have done an outstanding job in not only installing the panel, but training us on it. I cant say enough on how stress free they are making the transition for the crew, with their expertise and the ease of how they explain everything. This represents your company very well!! As I mentioned, I am interested in future training for my staff, not only on the LeeF Panel, but general chiller & refrigeration knowledge. " ~ Mr. William Hurd -Chief Engineer, SL Green
SUMMER 2014 Industrial Cooling Inc. completes State Energy Project with commissioning of (3) Trane CVHF Chillers with the proven TURBOCHYLL Min-E Variable Speed, Variable Displacement Control System. Utilizing our HYPERCHYLL Variable Speed - Preswirl integration to the chillers found an unprecedented capacity control range that was incredibly stable says commissioning engineers M. Santonocito and P Recchia. KW per ton and capacity reduction experienced immediately at startup was beyond anything the chillers experienced in their 17 year prior operating history. While both expectation and approach as base lined was presented on the optimistic side of performance -I can say the package beat my every expectation and certainly that of ownership says Recchia.
ElectroSensors & ICACS shared success for applied systems for TurboChyll products
TCO Optimizer
From a position of design,a compressor's capacity control vane assembly will pre-rotate the inlet gas entering the varying downstream stages into a very efficient and dynamically optimized gas shape-affording control offering a significant capacity range. This feature is a highly efficient means to control over a great energy benefit however is limited to a region of about 60-100% vane opening.
This optimized region of vane position is referred to as compressor pre-swirling.
While the vane assembly can and will close further, regions below 45-50% present a significant impact to energy and stability. As the vanes are demanded to further close, a gas dampening rather than preswirling condition becomes ever more influential. These lower vane positions are simply not desirable to energy savings. Therefore a more efficient approach that will maintain the vanes in a region of pre-swirl, yet afford the turndown requirements would be considered highly favorable. The TurboChyll logic, via VST-OCP affords this feature.
When compressor lift (head) obligations are reduced, mostly through lower than design entering condenser water, gas flow can be afforded through the compressor with far less energy requirements. As a result, the VST functions via the compressor's turbine drive to a lesser more optimized output demand-conserving unnecessary HP and energy.
As the turbines continued intentful optimization and rerating occurs, the chillers water temperature logic is now obligated to maintain the leaving chilled fluid setpoint (LFS) by preswirling the vanes opened into the desirable region of optimization.. If however requirement (higher ECWT) or abnormally low capacity loads are encountered, both the compressors vanes and turbine output will correct with a priority to presented load.
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The LA Times and the San Diego Union-Tribune jointly opined on their websites in favor of SB 1004, which I joint-authored with the good Senator from San Francisco, Scott Weiner, and encourage the Governor to sign it.
How's that for working with those on the other side of the aisle? I have an established history with addressing how to better direct Mental Health Services Act funding. With that focus, Sen. Weiner requested my collaboration on his bill (see MOORLACH UPDATE — Joint Author Details — July 7, 2018). The lead editorial is the first piece below.
The second piece is more than a year in the making. I was interviewed by the San Francisco Chronicle last year. They have done some very exhaustive analysis over this time period on CIRM, the California Institute for Regenerative Medicine (see MOORLACH UPDATE — I Told You So! — August 26, 2017 ).
The bonds that funded this dubious venture cost the General Fund $313 million in the current fiscal year and will cost $309 million in the next! Your taxes are paying for what I believe is the most egregious ballot measure abuse in recent state history.
I'm not against stem cell research. But, if there is progress and money to be made in this area, the private sector and institutional investors will make it happen. But, in 2004, when Proposition 71 was up for a vote, I was one of the three signatories in opposition to this measure because it was self-serving, unaccountable, and would be a fiscal bust (as the major patents had already been secured by the University of Wisconsin).
I recently did try to address my concerns about CIRM through the legislative process (MOORLACH UPDATE — Millstones and SCA 7 — March 30, 2017) and through messaging (see MOORLACH UPDATE — Showmanship Let Down — October 7, 2017).
Now the Chronicle provides a review of where the money went. Although thorough, it is silent on the administrative costs. That may provide information on high salaries and, therefore, high pensions, for well situated individuals who served in cushy positions. The piece also begs the question as to facilities. You can do research in a rented commercial building. But, I'll save the rest for your reading pleasure with the second piece below.
California is sitting on hundreds of millions of dollars for mental health programs. Let's put it to use
Like much of the rest of the nation, California went only halfway toward keeping its promise to improve mental health care. It closed psychiatric hospitals, some of which were really just costly warehouses for the sick rather than modern medical facilities offering effective treatment. But the state didn't follow through on its commitment to provide better alternatives, like community-based clinics that deliver the treatment and services needed to integrate patients into society, working and living independently where possible.
We can see the result of those half-measures every day. About a third of homeless people in Los Angeles and across the country are on the street because of untreated mental illnesses that prevent them from staying housed or holding down a job.
We've begun to make amends, at least of a sort. Fourteen years ago, voters passed Proposition 63, known informally as the millionaires' tax and more properly as the Mental Health Services Act. It raises billions of dollars for services.
The ranks of mentally ill homeless Californians are constantly being replenished.
More recently, Los Angeles voters adopted tax measures to raise money for supportive housing – units that will give homeless people, including those with serious mental health challenges, the opportunity for dignified and independent living while receiving the medical care and services they need to hold their illnesses at bay and stay off the streets.
These are fine programs, but if they're all we've got they will be futile. The ranks of mentally ill homeless Californians are constantly being replenished. As fast as we can lead the sick and suffering into homes, they are replaced on the street by new generations of people whose mental illnesses were left undiagnosed or untreated at an early stage, when they still could have been held in check. If only California also had funding for that – for prevention, diagnosis, intervention and treatment early enough that patients' illnesses do not progress to the point where they lose the ability to lead independent lives.
Actually, we do have the funding. The tragedy is that we haven't spent it wisely, or in many cases haven't spent it at all.
Twenty percent of Proposition 63 funding allocated to counties is supposed to be spent on prevention and early intervention programs and treatment. Yet a recent state audit found that counties hadn't spent most of that money, despite statutory deadlines meant to deter hoarding. Hundreds of millions of dollars just sit in county accounts, still waiting to be put to use.
Why? There is too little guidance on how to effectively spend those tax dollars. A state Mental Health Services Oversight and Accountability Commission is supposed to direct counties to best practices, but that loose system has led us to where we are: unmet needs and unspent funds. There is little strategic vision. Programs aren't measured for their effectiveness. Counties aren't held accountable for results.
The law should be tightened to ensure data are gathered, outcomes are measured and the commission offers more exacting spending guidance that prioritizes treatment for young patients.
After all, researchers have found that signs and symptoms of mental illness – hallucinations, delusions and other evidence of psychotic episodes – first present themselves in the patients' early teen years and into their mid-20s. Treatment at or just after the onset of these symptoms can prevent, or at least allow patients to manage, serious mental illness that worsens over time. Failure to respond quickly makes effective treatment later in life much more difficult – and feeds the pipeline that sends sick adults to the street.
A bipartisan proposal from state Sens. Scott Wiener (D-San Francisco) and John Moorlach (R-Costa Mesa) would provide the appropriate spending guidelines and promote some uniformity in treatment around the state while leaving counties the flexibility to spend on different priorities if they can make a persuasive case for them. The measure (Senate Bill 1004) cleared the Legislature and is now on Gov. Jerry Brown's desk.
Brown's Department of Finance opposes it, arguing that the commission can do everything the bill can simply by changing the appropriate regulations. Perhaps it could – but the point is that it hasn't.
Some critics object to the move to increase the focus on the young. Yet that's where the greatest need is for prevention and intervention services, and where funding can provide the greatest value. Besides, the bill would also direct funding to programs that address the particular mental health challenges of older people as well. The bill is a targeted solution to an exasperating problem. It deserves the governor's signature.
Taking stock of California's $3 billion bet on stem cell science
Erin Allday and Joaquin Palomino
It was an extraordinary political proposal: Approve a $3 billion bond measure to fund the cutting-edge science of stem cell therapy, and soon some of the world's cruelest diseases and most disabling injuries could be eradicated.
The 2004 measure was Proposition 71, the California Stem Cell Research and Cures Initiative. The campaign to pass it was led by a Palo Alto real estate developer whose son suffered from an incurable illness that he believed stem cells, the keystones of human biology, could heal. Other supporters included preeminent scientists, Hollywood celebrities, business leaders and elite investors.
The need was urgent, they said. Federal restrictions had recently been imposed on funding research involving human embryonic stem cells, then the most auspicious field of study.
Among the campaign's promises: Nearly half of all families in California could benefit from stem cell treatments Prop. 71 would help create. One study it commissioned found that new, life-changing therapies could emerge in just a few years. And Prop. 71 would pay off financially, the campaign claimed, creating thousands of jobs and potentially returning the state's investment more than seven times over.
"How many chances in a lifetime do you have to impact human suffering in a really fundamental way, including possibly even in your own family?" Robert Klein, the campaign leader, would say shortly after the vote.
In November 2004, Prop. 71 passed with nearly 60 percent approval. It created the California Institute for Regenerative Medicine, or CIRM, an agency tasked with administering the $3 billion and making the campaign's lofty visions a reality.
Fourteen years later, the money voters approved is nearly gone, and supporters of CIRM and the research it funds are preparing to ask the public for another $5 billion in 2020. This time, taxpayers will want to know: Has California's initial bet on stem cell science paid off?
Over the past several months, The Chronicle conducted an extensive analysis of CIRM's spending, reviewing the nearly 1,000 grants the agency has made, tracking how the money has been spent, and gauging whether the promises have been realized.
It's not a question that can be answered simply. Science often can't be measured in quantifiable outcomes. Failures aren't just common, they're necessary — it's impossible to expect every dollar invested in research to lead down a traceable path toward success.
CIRM can take credit for some notable progress.
It has helped make California a global leader in the field that's come to be known as regenerative medicine. Anywhere significant stem cell research is taking place in the state, it almost surely has received support from CIRM.
At UCLA, doctors are using stem cells to cure a rare immune deficiency disease that kills children. At Stanford, early studies show that stem cells deposited deep into the brain could restore movement and speech to people devastated by stroke. At UCSF, a team is beginning human trials for a fatal genetic blood disease that involves transplanting stem cells into a fetus still in the uterus.
But as thrilling as such advances are, they fall far short of what Prop. 71's promoters promised.
Not a single federally approved therapy has resulted from CIRM-funded science. The predicted financial windfall has not materialized. The bulk of CIRM grants have gone to basic research, training programs and building new laboratories, not to clinical trials testing the kinds of potential cures and therapies the billions of dollars were supposed to deliver.
Over that same time, many people suffering from incurable diseases have become impatient waiting for scientists to produce the miracle treatments the Prop. 71 campaign said were within reach.
Instead, a thriving, for-profit industry of clinics offering dubious stem cell therapies based on half-baked science has sprung up, defying attempts at government regulation and requests from scientists to proceed cautiously.
Now, as CIRM supporters prepare to approach voters again, some say its achievements shouldn't be measured only against the claims made by the campaign that created it.
"What was promised was not deliverable," said longtime CIRM board member Jeff Sheehy, a former San Francisco supervisor. "However, I would distinguish the promises from the impact and value. We have developed a regenerative medicine juggernaut."
Klein, though, is unapologetic about the campaign he led. Indeed, as he lines up advocates and testimonials for the coming campaign, his message is familiar: Fund this research and we will save lives. Slow it down and the consequences will be grave.
"Do you want your son to die? Are you going to wait?" Klein asked recently. "Is that the price you are prepared to pay?"
In his airy, sunlit lab at San Francisco's Gladstone Institutes, cardiologist Deepak Srivastava has used skin cells to produce heart cells. As they pulse in a petri dish, their steady, calming beat feels familiar, even viewed through the lens of a microscope.
Someday, he hopes, the work of his team at Gladstone's Roddenberry Stem Cell Center will lead to a therapy that can reverse the effects of a heart attack.
"We got this far purely because of CIRM," said Srivastava, the center's director.
The dream of exploiting the human body's remarkable ability to heal itself — to grow skin and bone, to replace muscle lost to wasting or disease, to undo systemic damage caused by infection — has long captivated medical scientists. In the late 1800s, they began to suspect that specific cells in the body were responsible for this repair and regeneration work.
A century later, in 1981, UCSF scientist Gail Martin gave the most powerful of these cells a name: embryonic stem cells.
It wasn't until 1998 that the first human embryonic stem cells were isolated and replicated in a lab. These cells are uniquely potent, responsible for building every part of a human body. As an embryo matures, it rapidly replicates, transforming into bone cells and muscle cells, brain cells and heart cells.
Some doctors believed if they could harness stem cells, they could use them to treat all but the most disastrous threats to the body, perhaps even reverse the natural effects of aging.
The process of isolating them, though, involved destroying days-old embryos. Religious and antiabortion groups decried the science as unethical. In 2001, President George W. Bush instituted far-reaching limitations on federal grants for embryonic stem cell research.
In California, advocates for regenerative medicine sought a way around the funding restrictions. Their solution: Prop. 71, which would generate $3 billion in general obligation bonds, the type more often used for infrastructure projects like highways or dams. Including principal and interest, the total cost to taxpayers would be roughly $6 billion.
State-funded scientific research on that scale had never been attempted and, despite the campaign's pitch, there was no guaranteed payoff. The state Legislative Analyst's Office offered a cautious assessment: The potential financial benefits were unknown.
Klein, then a major Silicon Valley developer, helped conceive, bankroll and write Prop. 71. For him, the effort was personal. His son, Jordan, had recently been diagnosed with Type 1 diabetes, and Klein had become a ferocious advocate for people with brutal conditions and little hope.
More than 20 Nobel Prize laureates backed the proposal. So did Hollywood celebrities such as Michael J. Fox and Brad Pitt. Million-dollar donations came from the founders of eBay and the owner of the Cleveland Cavaliers basketball team.
Radio and television ads featured gut-wrenching appeals from people with incurable diseases. Patient advocate Joan Samuelson, later appointed to CIRM's board, said in one ad that Prop. 71 "will rescue me, and a million people with Parkinson's disease."
In another, "Superman" actor Christopher Reeve, paralyzed from the neck down after a horseback-riding accident, said "stem cells have already cured paralysis of animals," and called them the "future of medicine." Dependent on a ventilator attached to his trachea, he struggled to breathe and to speak in the ad. He died before the spot aired.
Almost immediately, critics filed lawsuits. CIRM, the new stem cell institute, lacked public accountability, they said. While technically it was a state agency, the measure gave the Legislature little direct oversight of it. The legal challenges eventually were dismissed, but they slowed funding for nearly two years.
Meanwhile, the confident claims of the campaign were being tempered with more modest expectations. A year after moving into its San Francisco headquarters, CIRM would unveil a 10-year plan dramatically scaling back the pledges made by Prop. 71.
The field of embryonic stem cell research was still young, the report warned. The road to marketing new therapies would be long and expensive. Most research never reaches human clinical trials, it explained, and most of those trials fail. Potential treatments for just a handful of diseases might be tested, and it was doubtful that a single approved therapy would be developed from the state's investment.
"The whole tenor of the campaign, what was said on television ads that flooded the state and by Bob Klein and his lobbying group, was that if California would fund this work, there would be cures," said Marcy Darnovsky, executive director of the Center for Genetics and Society in Berkeley. "People that were saying that must have known you can't schedule medical breakthroughs. Those hopes were just that, hopes, and completely speculative."
But as CIRM ramped up, The Chronicle's review shows, it began doling out grants at a furious pace, averaging more than $7 million a week in 2008, its first year of full-fledged operation. To date, CIRM has spent or committed more than 90 percent of its $3 billion allowance.
The grants can be broadly divided into four categories: basic science and training; infrastructure; translational and preclinical, which is the work that goes toward moving laboratory science into human studies; and clinical trials.
The Chronicle reviewed CIRM grants through May 2018, tracking who received money and how it was spent.
Bay Area institutions have been especially well-funded, with more than one-fifth of the bond money funneled to Stanford, UCSF, UC Berkeley and the Gladstone Institutes. Stanford, the biggest beneficiary, has received $360 million in grants. CIRM's funding of Stanford, a private institution supported by a hefty endowment, has at times been sharply criticized.
Nearly 40 percent of the total bond money, more than $1.1 billion, has gone into training programs and basic research — work largely aimed at improving scientists' understanding of stem cells and how they might be best used in medicine.
These basic biology studies have helped scientists develop techniques that could prevent immune rejection from an organ transplant. They discovered weak points in cancer stem cells that might become new targets for drug therapies. In addition to Srivastava's beating heart cells, scientists have used stem cells to build mini-organs, including "brains" in petri dishes for testing drug therapies and learning more about diseases like Alzheimer's.
CIRM's focus, meanwhile, has expanded beyond embryonic stem cells. It has funded research involving adult stem cells, which exist in pockets throughout the body and are cheaper and less controversial than embryonic stem cells. It's also invested in induced-pluripotent stem cells, first developed in 2006. Produced from other types of cells, they look and act like embryonic stem cells.
CIRM-funded researchers have published more than 330 scholarly articles in four of the most respected stem cell and academic journals. Each represents a new discovery in the field and has enabled the work California has funded to reach scientists around the world.
CIRM's investments in infrastructure have amounted to $482 million — 16 percent of the bond money. Most of that went toward building a dozen stem cell research centers.
UCSF received a $35 million grant to help raise a glass-and-metal structure on the hillside overlooking its Parnassus campus. The independent Buck Institute for Research on Aging received $20 million toward a sleek white building on its Novato grounds. Stanford University won the largest single grant: $43.6 million toward a four-story structure at the edge of its medical school campus built around a glass-walled atrium.
About $388 million has gone toward preclinical and translational research: studies that take science out of the lab and try to apply it to humans. This phase of research, seldom backed by the federal government, can be particularly challenging. A therapy that looks promising when tested on a cluster of cells in a laboratory-controlled environment often fails when given to more complex organisms.
The preclinical studies funded so far reflect the immense possibilities stem cells offer: Scientists have examined a gene-modifying technique to try to treat HIV. They're studying small molecule drugs that could destroy leukemia stem cells. They're developing a gel derived from pig muscles that could stave off amputations among people with a disease that weakens blood circulation.
The research has helped CIRM-backed scientists license 107 invention disclosures. Some of the studies have paved the way for clinical trials, while others have hit dead ends.
CIRM funding helped push UC Irvine scientist Henry Klassen's work from lab studies to clinical trials testing a stem cell therapy for a rare form of blindness. His research, which has shown success, has largely been carried out in a building at UC Irvine partly underwritten by CIRM.
"The whole reason I'm here in California is because of CIRM," said Klassen, who had been working in Singapore and took a job at Irvine shortly after Prop. 71 passed. "This consistent source of funding has been critical as we go from the bench to the bedside."
Still, critics and supporters alike say those who pushed Prop. 71 significantly oversold the short-term medical and financial prospects of stem cells.
No federally approved treatments have been produced. And without marketable therapies, the public is still far from reaping the up to $91 billion in health care savings by 2040 the campaign predicted.
CIRM has funded nearly 50 clinical trials, but just four have been completed, meaning scientists enrolled all the patients they said they would and finished compiling data. One of those trials was an observational study that tested no new therapy. The others involved treatments that are still years, at best, from reaching the market.
The state, once told to expect as much as $1.1 billion in royalties from CIRM-backed discoveries within 35 years, so far has received just a tiny fraction of that amount: a single payment of $190,000 from the City of Hope medical research center in Los Angeles County.
Other economic benefits, such as tax revenue and new jobs, have been measured only a handful of times. The most recent study, which CIRM commissioned using public funds and published in 2012, showed the state investment had helped create tens of thousands of jobs and generate hundreds of millions in tax revenue.
The aim of the report, however, was to aggressively support the goals and initiatives of CIRM, according to the California Stem Cell Report, a blog that has diligently tracked the institute.
CIRM and its 29-person governing board, meanwhile, have been a frequent target of attack.
State lawmakers have introduced multiple bills aimed at making the institute more accountable to the public and at ensuring that all taxpayers, not just biotech companies and universities, would benefit from the public investments.
Almost every effort has failed, in part due to the unusually restrictive language of Prop. 71: Any change in CIRM's structure needs a voter initiative or a 70 percent vote in both houses of the Legislature and the governor's approval.
The proposition also specified the precise makeup of the agency's governing board, placing representatives of many of the institutions that CIRM funds to oversee its grants. Having such built-in conflicts of interest without the oversight expected of a public agency has undermined CIRM's legitimacy, critics say. They have likened it to an insiders' club that enriches its own members.
"These guys got away with an incredible amount of personal enrichment," said state Sen. John Moorlach, R-Irvine, a longtime critic of CIRM. "And all they gave us was debt."
CIRM leaders say they have strong protections to ensure that personal interests don't influence funding decisions: Board members don't discuss or vote on proposals they have a financial stake in, and an out-of-state review panel has a major say in which projects are funded.
Multiple audits, however, have found the sheer volume of recusals troubling.
Records obtained by The Chronicle showed that board members abstained from voting on grants roughly 1,770 times since 2006 due to reported financial conflicts. Tens of thousands of additional recusals were triggered by a CIRM policy that bars certain members from weighing in on any application.
In some cases, nearly half of the board was unable to vote on major and controversial proposals due to conflicts of interest.
One board member, UC Regent Sherry Lansing, a former film studio executive, has recused herself from more than 400 grant discussions because of a tangle of conflicts, most related to the universities she oversees. Lansing's role is to advocate for cancer patients.
A pivotal Institute of Medicine review in 2012 found that such widespread conflicts had caused some to "question the integrity and independence" of CIRM, and it recommended sweeping reforms. Many of the suggestions were not enacted, although CIRM did make some significant changes shortly after the report published.
Klein, CIRM's board chairman during its first seven years, has been a divisive figure. Despite his role at CIRM, he continued to run a patient advocacy group that regularly dismissed concerns about the agency and attacked many people, including legislators, who challenged it. A 2009 Little Hoover Commission report called him "a lightning rod for calls for more accountability." There were multiple demands for his resignation.
"There's a reason you have checks and balances, transparency and accountability when you use that much in public funds, and unfortunately none of that was in place," said former state Sen. Deborah Ortiz, who strongly supported Prop. 71, then became a CIRM critic. "You can't go to the voters and say, 'Let's use $3 billion in state funds,' then say, 'We don't want the terrible government to bother us.' "
Even some of CIRM's most ardent supporters — patients and patient advocates who stand to benefit most directly from stem cell therapies — have become critical. Their chief complaint: The science is taking too long, and they're running out of time.
At the Gladstone Institutes' Mission Bay campus last fall, CIRM held a public meeting to update patients about the research going on throughout California.
CIRM representatives and scientists told the story of a mother who had her vision partially restored after enrolling in Klassen's trial at UC Irvine. They talked about an East Bay teenager, paralyzed the day before graduating high school, who regained some movement after receiving a stem cell transplant.
The $3 billion bond, they said, had made these achievements possible.
"What you will see over the next decade," Srivastava of the Gladstone Institutes told the crowd, "are a series of breakthroughs for many diseases based on that investment."
Not everyone shared his enthusiasm.
"I've met hundreds, thousands of people with spinal cord injuries," Franklin Elieh, a quadriplegic man and patient advocate, said at the same meeting. "Millions are suffering needlessly and endlessly. Billions (of dollars) are being spent needlessly and endlessly. What can be done to really accelerate this?"
Elieh, like many people living with incurable diseases or conditions, is disillusioned with the dearth of clinical trials CIRM has backed.
Clinical trials are the goal of laboratory medical science. They are the moment that a possible treatment, studied only in a test tube or a dish or an animal, finally is tested on a human subject.
The first two trial phases primarily test safety: Does this treatment, when given to a human being at an effective dose, cause intolerable side effects? Phase 3 trials are typically the first to tell scientists how well a therapy works in large groups of patients, if it works at all. They are often the last step before scientists — usually working with a for-profit company that has financed the increasingly expensive research — seek FDA approval.
About 900 patients have been involved in the 49 clinical trials CIRM has backed so far, The Chronicle's review shows. Nearly a fifth of CIRM's funds, about $530 million, has gone to support the trials. Most of those grants were awarded in the past three years, part of a deliberate effort by the agency to direct more money toward testing treatments.
"Every single project we have is spectacular, and just a couple of years ago may have been considered science fiction," CIRM President Maria Millan told a state legislative committee in August as she outlined many of the clinical trials the agency has funded.
Only six of the clinical trials, though, have been phase 3 studies. Of those, two were terminated or suspended, three are still recruiting patients, and one — for a bioengineered blood vessel that can be used in dialysis — is under way.
Meanwhile, the National Institutes of Health, the primary federal funding agency for medical research, has far outpaced CIRM in supporting clinical trials in stem cell research. A 2017 analysis by STAT, a science and health news publication, found that, dollar for dollar, the NIH funded 3½ times as many clinical trials as CIRM from 2006 to 2016.
In 2009, President Barack Obama lifted most of the restrictions on federal funding of embryonic stem cell research, but for both agencies, trials using those cells remain rare.
"When we voted for Prop. 71 we wanted clinical trials, we didn't want basic research," said Judy Roberson, a longtime CIRM supporter who has lost five family members, including her husband, to Huntington's disease. Roberson has 17 other relatives who are also at high risk of developing the hereditary neurological disorder, which slowly erodes a person's ability to walk and talk.
"Our loved ones are going to die. They're sitting on time bombs," she said. "You could do basic research for 100 years, but you're never going to learn everything. So just get in there and try something."
But accelerating the push of basic science toward human trials is not without its critics. The International Society for Stem Cell Research — the largest body of scientists looking at policy and politics in regenerative medicine — has cautioned against that approach. Many scientists say that, in general, it's too early to be experimenting on people, particularly with embryonic and induced-pluripotent stem cells, which may cause tumors.
Gene therapy, a field related to stem cells, underwent more than 30 years of grueling research and repeated setbacks before establishing its first commercial successes in 2017: two cancer treatments approved by the FDA.
Embryonic stem cells were isolated for the first time just two decades ago. Induced-pluripotent stem cells were made only 12 years ago. Adult stem cells — the cells responsible for regular repair and upkeep — have been used in bone marrow transplants for more than 50 years, but their application beyond that started to be deeply studied only in the 1980s.
The science simply isn't there yet, said Arnold Kriegstein, head of UCSF's stem cell center, who has received $2.5 million from CIRM for basic research.
"CIRM touts 50 or so projects moving toward the clinic, and many of them will likely fail," Kriegstein said. "It might be more prudent to spend dollars solving basic research problems, where a relatively modest investment can have a huge impact."
Some suggest that CIRM's recent aggressive support for clinical trials is directly tied to its plan to return to voters for more funding. The fact that its work is supported by taxpayers increases the urgency to produce results, said Timothy Caulfield, a Canadian law professor at the University of Alberta who closely follows CIRM.
"That creates a lot of pressure to frame the work in terms of near-future miracles, and that will almost always fail," Caulfield said. "True medical breakthroughs with broad application are incredibly rare."
To patients desperate for cures, CIRM leaders say stay hopeful. The work may be taking longer than promised, but it will pay off in the end. And the state has too much invested now to give up. Such hope, though, isn't easy to come by for those beginning to realize that any therapies to help them probably will arrive too late.
"We see how slow progress is, and we know a lot of people are never going to be candidates for a treatment," said Elieh, who is co-founder of the Northern California Spinal Cord Injury Foundation, a nonprofit patient support group.
Elieh, 54, was injured in a diving accident in 1989, shattering his vertebrae and damaging his spinal cord so badly that he lost movement in his legs and upper body. In the years afterward, he enrolled in clinical trials and costly rehab programs, but none helped.
During the Prop. 71 campaign, Elieh watched celebrities talk about the miraculous ability of stem cells to regenerate tissue. He saw videos of paralyzed rats that could walk again after receiving an injection of stem cells. Clinical trials, scientists said, were just years away.
"Everyone you talked with thought, 'Wow, we're going to put $3 billion into this,' " Elieh said. "It was really creating hope. And, unfortunately for me, false hope."
Over the past decade CIRM has funded two clinical trials testing the same treatment for spinal cord injuries. The therapy, though, applies only to people newly injured, not the hundreds of thousands of men and women like Elieh who have been paralyzed for years.
So far, the therapy has proved safe. A handful of patients in the second trial regained some movement, though it's too soon to say whether stem cells are the reason. While CIRM supporters are keen to hold up that trial as an example of the stunning potential of stem cell therapies, Elieh and many of his peers are more cautious.
"We've still barely taken the first step, and we have no idea when the second step will land," Elieh said. "We all had a lot of hope back then, and we've just kept hoping."
Seated on a stage before 50 people in a town hall-style meeting in Mill Valley, Art Torres had one word to describe the results of the CIRM-funded trial for spinal cord injuries: "Miraculous."
Torres, former state senator and longtime member of the CIRM board, was enthusiastic in a way that would have made the more cautious scientists running the trial cringe. But CIRM needs a home run.
The looming end of its funding — and the need to ask voters for billions more — presents an existential moment.
Since 2004, the political and scientific climate has changed significantly. Federal funding for embryonic stem cell research is no longer tied up, and many voters are savvier about the limitations of regenerative medicine. The scientists backed by CIRM, meanwhile, face unconventional competition from an unexpected source: a vibrant consumer-clinic industry that's marketing unproven therapies to those tired of waiting for cures.
Prop. 71's most tangible achievements — cutting-edge academic buildings, discoveries in petri dishes, advances in lab rats, pioneering trials in human subjects — aren't necessarily going to resonate with voters. What will are visible triumphs in real people. Those successes are what CIRM's most ardent supporters are rallying around.
On the cover of the agency's 2017 annual report was Ronnie, a wide-eyed infant who was cured of an immune deficiency disease called SCID, or "bubble-baby disease." Children who have the condition typically live in isolation to protect them from fatal infections.
CIRM has helped fund four trials, all at different institutions, testing stem cell therapies for SCID. Ronnie was treated at UCSF using a treatment developed at St. Jude Children's Research Hospital in Tennessee. A therapy out of UCLA, which has been in clinical trials since 1993, could win FDA approval — a first for CIRM-backed research — in a year or two, say the scientists who developed the treatment. In all, 40 babies have been treated with the UCLA therapy.
And there's Rosie Barrero.
In a video posted on CIRM's website, Barrero sits in a sunny room at the agency's headquarters, now in Oakland, Lake Merritt glittering behind her. She's earnest as she talks about retinitis pigmentosa, the disease that has slowly blinded her.
Barrero was treated in 2016 in Henry Klassen's trial for patients with RP. Within months, she could pick out colors and shapes she hadn't been able to see for years. She could tell her daughters apart. She has regained about "a pinhole" of sight, but that she's had any improvement at all, she said, is amazing: It means that the therapy works.
"We're definitely hoping that this work continues to get funded," Barrero said in an interview. "It's incredibly important, to all of us."
If a new bond isn't approved in 2020, said CIRM President Millan, it could devastate stem cell research in California. Private industry is still reluctant to back research that has yet to produce a treatment, let alone show it can be profitable.
And so, CIRM proponents are turning again to Klein, who plans to lead the 2020 campaign for more research dollars.
In Klein's downtown Palo Alto office, a series of photos — colorful, fantastical close-ups of stem cells studied by CIRM scientists — hangs above his desk. Once they'd hung in CIRM's offices. Today they reflect the deep connection he's retained with the agency, despite not having an official role since stepping down as board chairman seven years ago amid a flurry of criticism.
Late last year, Klein addressed the CIRM board at a meeting about the fate of the agency. According to polls he had paid for — the full results of which he declined to share — 70 percent of voters would support another stem cell funding proposition. No other options for future financing — not private fundraising, not legislative efforts — would work, he said.
It was his son Jordan's battle with Type 1 diabetes that drove Klein into patient advocacy and stem cell research. But the therapies that Klein believed were imminent did not arrive in time to save Jordan. Two years ago, at age 26, he died from complications related to the disease.
The loss seems to have cemented Klein's resolve.
"We couldn't get there fast enough for Jordan," Klein said. "We have to get there for everyone else."
Klein rejects the notion that expectations for CIRM were overhyped or voters misled in the 2004 campaign. If cures aren't yet at hand, they're surely years closer than they would be without CIRM, he said, and people already are benefiting from research paid for by Prop. 71.
During an interview in his office, Klein played a brief video of a young man who is part of the spinal cord injury trial CIRM has helped fund. Made quadriplegic after a devastating car accident, the man is shown in the video lifting weights.
"After the stem cell surgery, I'm able to live my life again,' the man says in a quiet, halting voice. "Thank you for giving me my life back."
Klein turned off the video, his eyes bright.
"I wish all the voters could see this," he said. Christopher Reeve, whom he considered a friend, "would have been absolutely ecstatic" to have seen such a video, he added.
"In 2004 we had a vision of the future and data on animals," Klein said. "In 2020, we will have patients who were paralyzed, patients who were blind, patients with cancer who will tell their story. The public will decide."
Erin Allday and Joaquin Palomino are San Francisco Chronicle staff writers. eallday, jpalomino Twitter: @erinallday, @JoaquinPalomino
This e-mail has been sent by California State Senator John M. W. Moorlach, 37th District. If you no longer wish to subscribe, just let me know by responding with a request to do so.
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Secure Industrial Ethernet solutions
RADiFlow is a provider of Secure Industrial Ethernet solutions for Critical infrastructure applications. The company provides an innovative network design for utilities based on its ruggedized switches which contain an integrated SCADA firewall. Such a distributed network-based security deployment protects against attackers that have gained access to the internal operational network (e.g. Stuxnet scenario).
Smart Steering Wheel Cover
Mobile Phone Mount for Vehicle
wireless broadband in motion
Improve train safety by automated obstacles detection
Plastic Ventilation Systems for the Auto Industry
Smart gadget installed on the steering wheel
Parking Places Mapping App
Infotainment systems
controller to extend battery's life
hybrid military vehicles
Cyber Security Shield For Drones and Robots
Prevents texting among truck drivers
Rent your own car while it unused
Connects parking seekers with parking space owners.
Automotive Imaging Radar Sensor
Multimodal transportation solutions
Mobile App for Taxi Booking and Service
Optimal usage of public transit
Social ride sharing platorm for families
Foldable Compact Tricycle
Unified Plastic Manufacturing & Assembling
Repairing Potholes better and at lower costs.
Obstacle Detection Sensors
Robust microbial-based platform
fueling system
Improved plant traits for the biofuel industries
Internal combustion engine reducing fuel consumption
Enables businesses to provide various services with their customers
Embedded Voice User Interface in Vehicles
Software which measures distance
Safe Drive Systems
Traffic management system
Documents traffic offenses
Traffic and Parking Enforcement Solutions
Vision algorithms for Autonomous cars
solution for traffic, transport and logistics
marketpalce for private car parking spaces using in real-time when a parking space is empty without requiring any device installation in or near the empty space.
Security solutions for IoT and connected cars
satellite communication on chip
Booking and purchasing tickets for the train
Safety app to prevent using phone
connect the phone to the car
microalgae for an alternative energy source
predict danger on the roads
Vegetation Analysis Based on a Camera Mounted on UAV
car share / ride share
Endless-Route Multi-Passenger Taxis
Shared transportation management system
Noise control
New gen of ITS
Wide range of stabilized real-time aerial surveillance platforms
Aerial display system
Waterproof drones with backpack storage
Personal Rapid Transit based magnetic technology
Autonomous Agriculture Spraying Drones
Reducing potential errors and driver distraction by providing an additional touchpad conveniently on the steering wheel which would work in unison with a HUD to enable superior infotainment control and driver awareness, all while keeping their hands on the wheel and eyes on the road.
Marketplace for trips with buses
System for cities to examine the worth of executing a smart city project
Real-time parking information and payment
Private cars rental marketplace
In-wheel suspension technology
solar battery
Turn any surface into a solar panel
Performance enhancement of Composite Materials and Rubber goods
App for passenger distribution in public transportation carriages
parking using micro sensing
parking using sensors
Next Age of Automotive Marketing
silencing your phone while driving
advanced Automatic Vehicle Location Systems (AVL)
Smart parking for bicycle
AI-based Parking Marketplace
Navigation based diversed apps
fleet management
automatic flight control systems for helicopters
Premises Accessibility Solutions for Special Needs
emergency braking system
fast charging
manage and optimize all car services from taxis to autonomous fleets
Sun Shield for drivers
Optical Wireless Communication
Automated Air Traffic Management
Manufacturing Automotive Metal Parts
Bikes for families
app for fueling automation
build racing car
Demand Responsive Transport (DRT) service
Taxi ride share
new materials
Fuel Cell & Energy Storage
Aerial Mapping via Drones
EREVs (Electric Range Extended Vehicles)
Rubber to Metal Bonding Products for the Military and Civilian Markets
Aerospace components manufacturer
Smart Heating Fabrics
Deep learning training data for autonomous vehicles
State of the Art Human Detection
Revolutionary rotary internal combustion engine
Electric 3 wheeled board
Electric off-road utility vehicle
combustion engine with superior thermal management.
Cyber security for vehicles
diagnostic solutions
GPS tricking device
fleet management
Smart Traffic Management System
Informing Traffic lights about dangers
Develops and cultivates a variety of enhanced algae
Converting waste to fuel using a patented immobilized enzyme biocatalyst
Promotes Intelligent Transport Systems
Providing up-to-the minute ride information in public transportation vehicles.
IoT for motorcycle
Door to Door Carrying Solution for Daily Bicycle Commuters
analytics solution designed to accurately measure and determine demographic trends
Ride sharing
route planning
Synthetic crude oil from sewage sludge
Social Community for truck drivers
cloud based transport optimization
Share Empty Vehicle Space
Connects shippers to truck drivers and optimize the trucking industry
In-Car Voice UI platform
Range extender for electrical vehicle
Mobility devices for mobility impaired people
Unmanned Aerial Systems
face and eye tracking technology
Automation products, mainly PLCs
microalgae-biomass as feedstock for biofuel
Cloud based cybersecurity platform for the automotive market
VTOL Aircraft for Complex Urban Environments
Communication platform for authorities and citizens
Multi modal routing algorithm
Under-Vehicle Inspection System
Loitering Aerial Munitions Systems
swapping batteries solutions
audio and video process inside the car
Traffic control sys
RF based 3D Imaging sensor
On board car cyber security
Intelligent Mission Automation for UAV Fleets
On-Demand Transit
digital automatic aerial survey and mapping systems
monitor vehicles problems
HMC laser sensor for Voice control and Voice Biometrics
improve batteries
Improve fuel efficiency
Road accident predictor
Navigation solutions
Improve driving skills and reduce insurance claims and premium
Cyber security for vehicles
voice assistance
communication over batteries
City navigation app


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Reducing Blackbird DamageA good strategy to reducing blackbird damage is to plant as early as possible and desiccate the crop. In many cases producers have been able to get the crop all harvested before the birds even move in. The earliest planting date for Minnesota was April 21. In North Dakota, it is May 6 for most counties north of Hwy 200 and May 11 in the remaining counties based on USDA RMA earliest planting dates. Why take a chance when it comes to blackbirds when you can have a good sunflower crop? Maximize your return by planting early and get it harvested as soon as possible.New Field Guide Now AvailableCompendium of Sunflower Diseases and Pests is an all-new disease and insect compendium that will serve as a vital field guide wherever sunflowers are grown. It includes nearly 300 images and research-based management recommendations, allowing users to scout, identify, and manage a range of diseases and insect pests. NSA has worked with the publisher, The American Phytopathological Society, to secure an exclusive $30 pre-order discount for all NSA members. The book will ship in June 2016, but be sure to pre-order by May 31, to take advantage of this special offer. Use this link to order your copy.Sunflower Planting PointersWith sunflower planting just around the corner, paying attention to planter calibration and planter speed can go a long way to achieving a successful, uniform sunflower stand. Check out the top ten sunflower planting pointers here. Register Now for Summer SeminarRegistration is open for the 34th Annual Summer Seminar scheduled for June 28-30 at the Ramada Hotel in Bismarck, ND. Register online here. A block of rooms has been reserved at the Ramada for June 28-29 under the "National Sunflower Association." To reserve a room, call 1-800-554-7077. The program is being finalized and more information will be coming soon. Check our website for updates. See you in Bismarck!Pest Management App AvailableTired of carrying around those thick pest management guides? Download the NDSU Pest Management app -- it includes everything that is printed in pest management guides, plus more. For example, the app has full color photos of weeds, insects, and diseases. The app is available for both Apple and Android devices – just search NDSU Pest Management. The app is free, thanks to funding from several commodity groups, including the National Sunflower Association. Producers who use the app are encouraged to send comments and feedback to firstname.lastname@example.com About Stored SeedProducers who have stored seed are reminded to keep a close watch on seed moisture. It's a good idea to have bins probed and tested regularly to protect your investment.NSA on Social MediaStay up to date on what's happening at the NSA and share your photos with us via social media. Find us on Facebook and on Twitter.Upcoming EventsMay 29-June 3, 2016: 19th Annual International Sunflower Conference, Edirne, Turkey
June 28-30, 2016: 2016 NSA Summer Seminar, Bismarck, NDMarketsMarkets are being helped to some extent by a sagging US dollar as it hit a 9-month low last week. A lower dollar makes US exports more competitive on the world market. The slide in the dollar and rally in broad-based commodities has partly contributed to the oilseed rally this month. There's still a lot of talk about the final size of the Argentine soybean crop. Various estimates have South American soybean production anywhere from 1 million tons lower to 10 million tons lower. Such a backdrop is giving CBoT traders concerns about the ability of South American exports to deliver what they were expecting. Weather conditions have improved in Argentina; however, we will have to wait to see how the previous rain events effect crop quality. Traders are also keeping an eye on updates for Midwest summer forecasts. Sunflower prices are bucking the trend of lower oil values on the CBoT and holding their own. Oil has been pressured by weak palm oil prices and a rally in meal. New crop sunflower prices are very competitive with other crops and processors are still offering 2016 new crop cash and Act of God (AOG) contracts for fall delivery.
You can subscribe, unsubscribe or change your preferences in the newsletter section of our web site. SmartMail is a product of Odney.


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Some Fine Treasures: Nancy Whelchel Hickman studied at the Gemological Institute of America where she received her Graduated Gemologist designation in 1976. She worked as Senior Gemologist for the Army and Air Force Exchange Service and Senior Jewelry Buyer for a Fortune 500 corporation for nearly 30 years before returning to the Lake Charles Area. With her knowledge of the jewelry industry, it was just natural to open her own small business offering jewelry and gift items. She is grateful to be included with this wonderful group of antique dealers.
Her fine jewelry collection includes pearls, natural colored jade, and colored stones in 14k gold and sterling silver. She designs necklaces, bracelets, and earrings and offers jewelry repair and restringing. Nancy has helped to redesign or update pieces so that customers have a desire to wear their items again.
Also available are vintage and estate fine and fashion jewelry items and gift items. You will find crystal, porcelain, glassware and pottery; along with a pieces of wall art.


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The stars of GENERAL HOSPITAL have been in the limelight for quite a few years (some even decades!) and have become pros at walking the red carpet. Just for fun, we found some of the very first pics of GH actors like Maurice Benard (Sonny) and Kirsten Storms (Maxie), and one thing's for certain, they've all aged incredibly gracefully!
Click through the gallery to see the celebrities on their very first red carpet compared to now.
For more on your favorite GH stars, keep reading the ABC edition of Soaps In Depth magazine!


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Our Vision
The micro-blogging platform, Twitter, was inspired by the CB radio. We'd like to be the site that puts you in the passenger seat — and enjoy the small talk for the long-haul.
Our Story
Some of our fondest memories as kids were passing semi-trucks on the highway while pumping our fists in hopes to be acknowledged by an alert (and cooperative) driver to honk their horn. We never expected to build a website to highlight the lives and insights from these drivers.
Next Steps…
Do you know someone who would be awesome to be interviewed for this site? Let us know!


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New course, new organiser, new race!
The 2018 Race has raised
for local charities so far…
2017 total was £64,452
Registration for the 2019 New Swindon Half Marathon opening February 1st.
Stay up-to-date with race announcements by subscribing to our newsletter.
The New Swindon Half Marathon has a brand new route for 2017. The route takes runners past Swindon's landmarks. The predominately flat and fast course makes it ideal for beginners and elites.
Starting and finishing in the town centre, the new course is largely very flat, and brings runners through the various highlights of the town including the Magic Roundabout, the County Ground, the Oasis, the Railways, the McArther Glenn Outlet Village as well as Old Town before a downhill finish into the Town Centre, where we'll be finishing under the big screen of Wharf Green.
The New Swindon Half Marathon is a operating name of 113 Events Limited.
Registered office: LG running, 1 Boleyn Close, Swindon SN5 6JZ
By using our website, you agree to our Terms of Use.


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Cala d'Or is one of the tourist centres situated in the east coast of Mallorca. With its beaches located a few metres from shopping streets and hotels, it also has a luxury marina. In case you haven't been there, come into Cala d'Or…
Basic Information:
Cala d'Or-Santanyí: 13.4 Km.
Cala d'Or-Portopetro: 4.3 Km.
Vall d'Or Golf-Cala d'Or: 7.0 Km.


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Hola, Mexico and G'Day, Australia
We now welcome customers from Mexico and Australia!
We offer a choice of First Class International and Priority Mail International for both countries.
Shipping time for First Class International will take more than 10 business days while Priority Mail International, according to USPS, takes approximately 6-10 business days.


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The MadCap Software Scholar Program Welcomes
Wright State University Chooses MadCap Software to Best Prepare Students for Careers in Technical Writing and Provide them with a Competitive Advantage in the Workforce
La Jolla, CA and Dayton, Ohio — November 6, 2013 — Wright State University is joining forces with MadCap Software to ensure that students pursuing its Documentation and Usability course have competitive advantage and clear understanding of technical communication best practices when entering the workforce. The university is using MadCap Flare, the industry-leading authoring and multi-channel publishing product—supporting print, Web, desktop and mobile—to provide students with the most advanced authoring and publishing solution available today. By using MadCap Flare, students are gaining both the expertise and understanding of the modern techniques of technical writing and single-sourcing. Furthermore, access to the leading software program used by thousands of companies worldwide will provide students with a competitive advantage when entering the workforce.
Numerous sources now cite Flare as the most popular Technical Writing software, and so being able to help my students learn to use it will be a great benefit to their careers," says Lars Söderlund, Director of Professional and Technical Writing and Assistant Professor of English. "Single-sourcing is a necessary skill for Technical Writers to have, and giving students experience with a topflight program that automates single-sourcing as Flare does will be a great introduction to the practice"
"We are honored to have been selected by Wright State University to help shape the education and lives of its students in the art of Technical Writing" says Anthony Olivier, MadCap founder and CEO. "Through this partnership we are pleased that we can empower students to strengthen their knowledge of technical writing best practices and help ensure they enter the workforce with a competitive advantage."
About MadCap Scholar
The MadCap Scholar Program offers special discounts on MadCap's state-of-the-art technical communications software to help students, educators and universities gain access to industry-standard tools that support technical writing and documentation best practices. They include the ability to outfit labs with MadCap Software applications for free; free training, including the MAD Certification Test for teachers and professors, and discounts on software for current students. For more detail, visit https://www.madcapsoftware.com/education/scholar-program.aspx.
About Wright State University
Wright State is a university outside of Dayton, Ohio that has approximately 16,000 students. It offers graduate and undergraduate programs, including the English major with an emphasis in Professional and Technical Writing, and undergraduate and graduate certificates in Professional and Technical Writing. The population is largely non-traditional and/or first-generation college students. A Carnegie-classified research university, Wright State's faculty is dedicated to advancing the frontiers of knowledge, as well as applying it to real problems. Wright State ranks as one of Ohio's top state universities in terms of federal research. It is one of an elite group of universities doing research in cutting-edge fields—making new discoveries that are improving the world around us, and collaborating with corporations and businesses to create new jobs and provide qualified graduates for the workforce.
About MadCap Software
MadCap Software, Inc. is a trusted resource for the thousands of companies around the globe that rely on its solutions for single-source multi-channel authoring and publishing, multimedia, and translation management. Whether delivering technical, policy, medical, marketing, business, or human resources content, MadCap's products are used to create corporate intranets, Help systems, policy and procedure manuals, video tutorials, knowledge bases, eBooks, user guides, and more to any format, including high-end print, online, desktop or mobile. MadCap services include product training, consulting services, translation and localization, and an advanced developer certification program. Headquartered in La Jolla, California, MadCap Software is home to some of the most experienced software architects and product experts in the content development industry.
PR Contact:
Rebecca Hurst
Kinetic.PR for MadCap Software


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Resolution's new environmental sensor, Trident, was designed to be easily deployed in areas were wall mounted sensors are inconvenient. Trident's specifically designed underside draws water in, ensuring the leak is detected. This sensor also can detect low and high temperature changes, ensuring pets and belongings aren't exposed to harmful temperatures and pipes don't freeze during harsh winters.
Water damage is one of the most common and costly home insurance claims. Trident helps mitigate those risks by offering an easy-to-install sensor that can be deployed just about anywhere to help detect problems as soon as possible.
Trident helps detect leaks in areas that may otherwise go unnoticed, such as:
- Refrigerator
- Dishwasher
- Washing machine
- Water heater
- Sink
- Toilet
- Bathtubs
- Garage
- Cabin
- Vacation home
- Basements prone to flooding
Click below to learn more about Trident and get a copy of the datasheet!


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Register today for IQL18! This year's meeting focuses on strategies for succeeding in risk-based payment models, including Medicare Advantage.
Fresh perspectives on MA and risk from Humana, Boeing, Geisinger, MemorialCare Health System, HealthPartners Medical Group, and New West Physicians, P.C. See who's on the agenda.
AMGA will convene the CEO/President/Chair, COO/CAO, CMO/Medical Director, CNO, and CQO/Quality Director Councils in San Antonio. Agenda topics now available.
Making the shift from fee-for-service to value-based care is perhaps the most transformative change a healthcare organization will ever make. It impacts every aspect of operations: governance, technology, human resources, compensation, care processes, and beyond. And with escalating costs and patient health on the line, it's essential to get it right.
This year's Institute for Quality Leadership (IQL18) focuses on strategies for succeeding in risk-based payment models, including Medicare Advantage. Wherever you are on the risk continuum, IQL18 delivers the resources and relationships for managing risk.
7:30 a.m. - 8:30 a.m.
8:30 a.m. - 5:00 p.m.
5:00 p.m. - 7:00 p.m.
7:00 a.m. - 8:00 a.m.
8:00 a.m. - 9:00 a.m.
Bruce D. Broussard, President and Chief Executive Officer, Humana
9:15 a.m. - 10:15 a.m.
10:15 a.m. - 10:45 a.m.
10:45 a.m. - 11:45 a.m.
11:45 a.m. - 1:45 p.m.
1:45 p.m. - 2:45 p.m.
2:45 p.m. - 3:15 p.m.
3:15 p.m. - 5:00 p.m.
Adam Solomon, M.D., M.M.M., FACP, Chief Medical Officer, MemorialCare Health System, and Linda Brady, Health Care
Strategy and Policy, Provider Network Strategy and ACO Portfolio Manager, Boeing
5:00 p.m. - 6:00 p.m.
6:00 p.m. - 7:00 p.m.
8:00 a.m. - 9:30 a.m.
9:30 a.m. - 10:00 a.m.
10:00 a.m. - 11:30 a.m.
Beth Averbeck, M.D., Senior Medical Director, Primary Care, HealthPartners Medical Group; Ruth Benton, Chief Executive Officer, New West Physicians, P.C.;
and Jaewon Ryu, M.D., J.D., Executive Vice President and Chief Medical Officer, Geisinger
Moderated by Jerry Penso, M.D., M.B.A., President and Chief Executive Officer, AMGA


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Recently I got invited to a Plus Size Fashion Show with guest host Supermodel Emme at the Columbus Macy's. I've never been to a fashion show and I've only been to Columbus a couple of times - so I was pretty psyched! (I was compensated to do some social media for the event - but the excitement was au natural!)
Then it was time for the Fashion Show!
Emme was a great host - she travels around the country with the models and stylists to take these super cute plus-sized fashions to the people. This model was actually from Cincinnati so she had some other Cincinnati fans cheering her on!
WomanlyWoman.com! She got to walk her first runway - pretty cool! That dress was super cute too.
celebrity stylist!!! What???? I have to admit - it was pretty great having Michelle help me. She picked out outfits and clothing that I would never have chosen. I know the next time I need an outfit for something - I'm going to make an appointment with a Macy's Personal Shopper and get some help!
same bomber jacket (so much cheaper now!) and then had my own graphic t-shirt underneath and paired with some jeggings. Yes - I just bought jeggings. Oh my - the day has come. I don't look as cute as the model - but I like the outfit a lot.
I tried some of the pants similar to the models - but they weren't right for my shape. Here's a very similar pair to hers - they're great on her.
All in all - the fashion show was really fun and the experience with the celebrity stylist was great! It definitely opened my eyes about the cute stuff that the plus-size department at Macy's has to offer!