text:
Tag Archives: Activities
Webinar – Pronunciation – 2016 January
Thank you! Firstly, thank you to those home tutors who attended this first webinar of 2016. We talked a little about 'keeping your Teacher Profile alive', namely adding the five excursions to your profile page. If you haven't done that yet … Read More»
Cambridge webinar GenZ – 28th April 2015
Engaging 'Generation Z' Tuesday, April 28, 2015 3PM BST – 4PM BST Digital media are a major part of everyday life for Generation Z. In fact, it has been from the day they were born. Engaging the youth in activities … Read More»
Top tips for becoming a great home tuition English teacher
Teaching English in your own home is all about people and sharing information. To be successful at one-to-one English teaching you have to be able to bring your experience, knowledge and personality to the lessons. Your student will be staying … Read More»
How to do a needs analysis with a 1-1 student
Why do a needs analysis? In the niche market of one to one tuition, students have the wonderful opportunity to pursue what matters to them personally while teachers have the stimulating challenge of flexibly tailoring each course to a subtly … Read More»
30 tips for teaching 1-1
Most TEFL/TESOL courses and materials are designed with group teaching in mind. This means you may well need to adapt how you teach and materials for a 1-1 or 2-1 setting.
Choosing a graded reader: afternoon 'test'?
Graded readers can be an enjoyable way for learners to improve their English. Levels range from beginner to upper intermediate (B2). Oxford University Press provide a 'test' to help learners choose the right level. Of course what an appropriate level … Read More»
Teaching a 3-week General English adult course
Ideas for a 3-week course including detailed content of 1st week. Courses of 3 weeks and longer require rather more planning than shorter courses. These are some teaching ideas for a 3-week course. For a 20-hour teaching week you will … Read More»
Teaching European teenagers
Practical tips Teaching teenagers has much in common with teaching adults but obviously allowance needs to be made for their age, level of maturity, understanding, shyness, confidence etc. The following tips will need to be adapted for your own teaching … Read More»
Planning an English plus Culture course for the first time
A few tips to help you plan for this course. English plus Culture courses, popular with Japanese and more mature European students, generally place a greater emphasis on activities and less on academic learning but some students will still expect intensive English … Read More»
Excursions and activities
It's difficult to say precisely when an activity becomes an excursion or exactly how excursions or activities help develop a student's English. However most teachers realise how important they are as part of an English course. Here I am looking at … Read More»


text:
Strolling salamanders provide clues on how animals evolved to move from water to land
[unable to retrieve full-text content]
Around 390 million years ago, the first vertebrate animals moved fromwater onto land, necessitating changes in their musculoskeletal systems to permit aterrestrial life. Forelimbs and hind limbs of the first tetrapods evolved to support moreweight. But what specific mechanisms drove changes in bone function? The tiger salamander might provide some clues.

subset: commoncrawl


text:
Question asked to Councillor T Swift at the Calderdale Council Cabinet Meeting 8th May 2013
"At the Council Meeting on 24 April 2013, Calderdale Council agreed to call on registered social landlords operating in Calderdale to refrain from seeking possession of properties where arrears are substantially due to tenants struggling to cope with the impact of the 'Bedroom Tax'. Will Calderdale Council take the strongest possible action to urge registered social landlords to adopt this policy? What steps will the Council take in the first instance to effect this?"
"Calderdale Council meets regularly with Registered Social Landlords (RSLs) who operate in the Borough. As part of our meetings we are discussing the issue of how welfare reform is impacting on their tenants. During these discussions we are strongly encouraging RSL's to carefully consider the options available to them to assist tenants affected by the 'Bedroom Tax', whilst meeting their regulatory and legal requirements in terms of being a responsible landlord.
We will work in partnership with our RSL partners to provide housing advice, via our Housing Options service (provided at the Doorways Office, Woolshops) to all residents who are concerned about the impact of welfare reform on their housing situation. We have already ensured that those people needing to move home as a result of welfare reform changes are given additional priority within the Council's joint allocation scheme with Pennine Housing 2000.
The Council will monitor rates of possession by Registered Providers and review results as soon as there is enough data to identify trends."


text:
India's Satyam posts strong profit growth
Indian software outsourcer Mahindra Satyam on Thursday said its quarterly net profit soared more than ten-fold, beating market estimates, as demand for outsourcing grew.
The company, recovering from the country's biggest corporate fraud scandal, said net profit rose to 2.38 billion rupees ($49 million) for the three months to September 30 from 233 million rupees in the same period last year.
Analysts had forecast a profit of near two billion rupees for the financial second quarter.
Revenues jumped 27 percent to 15.78 billion rupees, the company said in a statement to the Bombay Stock Exchange on Thursday.
"We are on course in all our performance indicators -- profitability, growth and talent retention," Vineet Nayyar, chairman of Mahindra Satyam, said in a statement.
"We have shown significant growth momentum, despite the uncertain macro-economic environment," he added.
Mahindra Satyam, formerly known as Satyam Computer Services, stunned India in 2009 when its founder B. Ramalinga Raju admitted he had for years overstated profits and inflated the balance sheet by over $1 billion.
The fraud nearly pushed the group into bankruptcy and Raju, who was once a star of India's software boom, is on bail awaiting trial for conspiracy, cheating and forgery.
Tech Mahindra, a unit of Indian vehicle and farm equipment manufacturer Mahindra and Mahindra, bought Hyderabad-based Satyam after the scandal broke, allaying fears about its survival.
India's top-four software giants -- Tata Consultancy Services, Infosys, Wipro and HCL Technologies -- have all shown improved profit growth in the last quarter, helped by a weak Indian rupee and stronger demand for outsourcing.
India's IT and software services sector derives more than 90 percent of its revenues from providing technology services to foreign customers, particularly in the United States and Europe.
Despite their exposure to ailing US and European markets, India's software firms have been upbeat on the industry's outlook. The flagship sector is expected to post 16 to 18 percent annual export revenue growth.
Explore further
(c) 2011 AFP


text:
SPRINGFIELD, MA-The University of Massachusetts Dartmouth's men's golf team shot a team score of 320 and tied for fourth at the 11-team Western New England Invitational at the par-72 Veterans Golf Course Thursday.
The Corsairs tied the Western New England White team. Endicott finished first at 314, followed by Salem State at 316 and Nichols at 319. Trailing the Corsairs were Springfield at 325, Elms at 329, Westfield State at 332, the Western New England Blue team and Babson at 335, and Wesleyan at 364.
Junior Matt Connolly (Lynnfield, MA/Lynnfield HS) led the Corsairs with a 77, junior Kevin Rewinski (West Springfield, MA/West Springfield HS) came in at 80, senior Nick Jagoe (Westport, MA/Westport HS) shot an 82, senior George Gillmore (Cotuit, MA/Barnstable HS/Fairfield) shot an 81, and sophomore Brendan Kelleher (Hopedale, MA/Hopedale HS) shot an 84.
"It's encouraging because it was our best team total of the year, but we still left shots out on the course," said UMass Dartmouth Head Coach Joel Baptista. "We need to get better play, and get into the 70s, and that's what we'll be looking for this weekend. We had a nice effort from Matt Connolly with a 77, but when you leave shots out on the golf course, it makes a difference."
The Corsairs will return to action at the Johnson & Wales Invitational this weekend.


text:
Project Runway - Sew Much Pressurecomments (4) April 2nd, 2010
This week, the designers face their biggest challenge yet, distraction. Maya leaves, Anthony returns, a model quits the show, and the newly formed final six still needed to create a garment fit for Heidi to wear on the red carpet. In the end, there were only two designers with positive reviews, and four designers rounding out the bottom. Emilio and Anthony shared the spotlight with a double win. Mila, Jay, Seth Aaron, and Jonathan were all given poor reviews, and finally Jonathan was sent home.
Did you agree with the judges? Share your review in the comments below and check out our complete review on ThreadsMagazine.com.
Anthony Williams
Jonathan Peters
Comments (4)
If you are looking for a model ( who represents the real women, I'm your girl). Seriously Anthony, I would be honored to wear your designs.
Posted: 10:16 pm on April 7th
Posted: 6:29 pm on April 7th
Milla: I think she's also lost, and very frazzled to be the only woman left since Mya quit suddenly. I still like her stuff tho, even tho she's always done color blocking, If her dress had the bodice overlapped and maybe been a version of a low- hi-low hem it could've worked.
Seth-Aaron: He showed up in Portland on a local talk show last month......hmmmm, I wonder what's up with that? N E way, he also does a lot of the same stuff, i.e. lots of hardware on his designs. I would've done a strapless with the studs around the top of the bodice & maybe down the back seam and made it a true mermaid with a great train. I think that would've wowed the judges!
Anthony: Very good gown! Needs to be cleaned up, but good simple lines.
Emilio: Same for him, great dress...a bit too simple but I understand that the fabric is quite something, and I would've done a bit more with the thing on the right side...maybe a little more folds down the front, subtlely, tho.
Jay: Well I like the idea of the vertical ruffles, why didn't he just make it a longer version, like Johnathan should've? and maybe a bit of shine to one of the sheer fabrics in the mix of ruffles for RCD?
Posted: 6:38 pm on April 2nd
Posted: 3:43 pm on April 2nd
Get special offers, FREE eLetters and your FREE PDF bonus now.


text:
Travelers love us, and the feeling is mutual
Over 120k travelers like you have chosen Tripaneer so far. Hear what they have to say about us!
By proceeding, you confirm that you accept the Tripaneer terms and privacy policy.
We have sent you an email to validate your email address. Follow the link provided in that email to complete your registration.
Check your email for the confirmation email. It will have a link to reset your password.
Popular destinations
Select duration or date
Select a specific date
Samba, carnivals, football (soccer), capoeira, the Amazon…there are many things that come to mind when thinking of Brazil. But the world's fifth-largest country is also chock-full of kitespots.
Featured in countless surf movies and magazines, with perfect waves and endless barrels, the Mentawai Islands are one of the most sought-after surf trips on the planet.
Although only a stone's throw away from Bali, Lombok is very different from the hustle and bustle of its big sister. Still free from mass tourism and over-development, it has that raw natural beauty that most of Bali's coastline has unfortunately lost.
Over 120k travelers like you have chosen Tripaneer so far. Hear what they have to say about us!
through Tripaneer
recommend booking with us
4.5 star average organizer score
"the adventure was amazing, I met nice people and learned a lot in a nice way"
"Great place, conditions and support from the instructor to get to the higher level!"
"Great place, quiet, lovely accomodation, helpful staff."


text:
Seche Collage Overlay: Swatch and Review
Think that Seche is just for fantastic top coat? Think again, my friend. Seche does polish, too. And a glitter overlay topper called Collage Overlay; a chunky glitter mix comprised of silver holo bars, large silver holo and jumbo matte white hex pieces all joyfully swimming in a thick, clear suspension base. I don't dislike this. In fact I kind of dig it. Check it out! This swatch is one coat over OPI Tomorrow Never Dies and topped with Gelous.
Okay. Formula. This is pretty thick and you know me and thick. I thinned this out a goodly bit prior to swatching and it wasn't bad, at all. Application was pretty smooth and not horribly troublesome. Yep, I had a bit of fishing and placing to do; I expected it, I always do when I work with a chunky like this so no worries, certainly no ding. Dry time is good, as with many glitters. This dries a tad satin, plenty of top coat is needed to get it all perfectly smooth, glassy and ultra shiny and sparkly. I like to use a thick coat of Gelous, then top with Seche Vite. I don't know who came up with this combo, (it wasn't me!) but they are a freaking genius and I bow at their feet.
I was honestly expecting this glitter to be a stone bitch to work with and it wasn't. Colour me pleasantly surprised and happy to recommend this to you.
I typed then deleted a long, pissy rant about idiots who swatch, use up and gunk up polishes in stores. I was inspired by the fact that after I got this polish home, I noticed that the polish level was pretty low and the bottle neck under the cap was a hugely gunked up mess of dried base and glitter chunks telling me that this had been swatched. A lot. Gah! Just... Knock it the hell off already! Swatching, unless a bottle is marked "tester" and paper or nail wheels are provided isn't cool, it isn't right and you need to just not do it! Here in the US, most retailers accept returns on makeup and polish, if they don't provide testers for swatching before purchase so there is no good excuse to gunk up, contaminate and ruin polish and makeup for other people. In fact, may stores that offer testers, still accept returns! Just buy the product, take it home and try it out. If you don't like it, grab your receipt, return it and use the money to get something you will like. Don't mess things up for others.
Okay, mini rant over. Lesson learned, remember to check the neck of the bottle prior to purchase, even if it does freak me out to open polish in the store.
Have you tried this pretty glitter topper? What do you think of it? If you are interested in acquiring and trying it, Seche Collage Overlay is available at Sally Beauty supply. I wish that my local Sally's would get the Seche Colour line, too as I would love to try them.
Thank you so much for popping in and reading. Have a great Sunday and may your polish never bubble.
10 comments
- Samantha WestJanuary 20, 2013 at 7:46 AM
I saw someone the other week just painting their nails in Boots with one of the polishes on display. I think I just stood open-mouthed staring at her for quite some time. I don't know why people think that's any different to just stealing the bottle of polish. This glitter's very pretty though:)ReplyDelete
- erikatheicyoneJanuary 20, 2013 at 9:01 AM
I know... It boggles my mind that people open and use products in the store then out them back and walk away. I was reading in a blog, I think it was Scrangie about some broad who went into WalMart, picked up a bottle of polish, sat down in the middle of the aisle and painted her toenails. Closed up the bottle and put it back on the shelf. Gross. And tacky and... Gross!ReplyDelete
Thank you, It is, isn't it. :)
- Alison Rose LevyJanuary 20, 2013 at 1:26 PM
I just got Seche Collage and frankly I love it. The hexes are so shiny they look like mirrors. I did not find the formula to be thick at all. I could also see layering this over a deep colored polish with tiny glitter to create more depth.ReplyDelete
- erikatheicyoneJanuary 20, 2013 at 8:21 PM
Ooo! over tiny glitter is a good idea. I'll have to try it. :)ReplyDelete
I don't deal well with thicker polishes, I just struggle with them and this one was just thick enough, to me, to merit thinning. :)
I just used this on Saturday and never thought to thin it out-but mine seems to have a pink base not clear-I wonder if something ran in mine? I didn't try it over white to test out this theory, it just seems to be a pinkish base not clear and I think it stained my nails where some of the glitter landed-and this was after 24 hours of wear only!ReplyDelete
I have this irrational hate of bar glitter. lolReplyDelete
I Love seche in any form!ReplyDelete
- erikatheicyoneJanuary 22, 2013 at 7:02 AM
Hee hee! Many do. I think that bar glitter is kind of a love it or hate it kind of thing. I started out hating it but I have really grown fond of the stuff. :DReplyDelete
- erikatheicyoneJanuary 22, 2013 at 7:03 AM
I really want to try their coloured polishes, see if they are as fabulous as their top coat which I adore so much. :)
- AnonymousApril 26, 2013 at 12:51 PM
Pretty great post. I just stumbled upon your weblog andReplyDelete
wanted to say that I've truly loved surfing around your weblog posts. In any case I will be subscribing on your feed and I am hoping you write again soon!
Look at my homepage; diets that work for women
I love to know what you're thinking. I dig honest discourse and lively discussion, even a good debate. I do not dig hate speech or personal attacks either against myself or my gentle readers.
Comments are moderated to kill spam and link dropping and to ensure a harmonious community.


text:
Talk about your potent mixing of retro-inspiring eras: The Cool Wolf online slot game is kinda like a combination of the Michael J. Fox-starring Teen Wolf and 1950s styling (check out the fashion sense and gas-guzzling convertibles among the symbols set to see what we mean. Throw in a hint of current-day franchise Monster High with a Tarantinoesque soundtrack and you've got a slot game that's 100% Microgaming. Why?
First off, the folks at Microgaming aren't necessarily too big on the franchise names, despite the Dark Knight slots and Jurassic Park slots dotting their hundreds of titles – perhaps it has to do with the big slot game software producer's legal battles with J.R.R. Tolkien's estate over the failed Lord of the Rings slot, a game said to be the most expensive ever produced and was de-commissioned due to copyright issues. (Why pay licensing fees and percentage of profits when one can create an unbranded version recognizable and attractive to fans?)
Secondly, the Cool Wolf slot game is loaded with the sort of features Microgaming loves to include: The "243 Ways" feature, i.e. land a certain symbol anywhere in each of the first three reels and win, has just about become the default standard from ol' MG.
Cool Wolf also includes the cascade feature in which winning symbols are replaced by new ones "dropped" into place on the reels a la Candy Crush for the opportunity to win several times on a single spin; the fun is dampened slightly, however, when *all* the wild symbols – not merely those making up the actual wins – are removed along with the paying symbols.
Stacked wilds are in play here as well: On reels 3 through 5, these wilds may land in Cool Wolf, particularly helpful in that middle position at making up some nice wins. The Cool Wolf slot's "Howling Wild" feature is a free spins bonus round in which the player is guaranteed expanding wilds on every spin in reels 2, 3 or 5.
Finally, there's the top payout: At 105,000 coins, it's positively, well, Microgaming-sized!
The Cool Wolf slot machine: 50s meet 80s in the 10s for a 1000% authentic online slots experience.


text:
Charles Dillon Perrine
This article needs additional citations for verification. (February 2012) (Learn how and when to remove this template message)
Charles Dillon Perrine
Charles Dillon Perrine
|June 21, 1951(aged 83)
|Known for
|Scientific career
|Lick Observatory
Charles Dillon Perrine (July 28, 1867 – June 21, 1951) was an American astronomer living in Argentina. He won the Lalande Prize in 1897.[1]
Born in Steubenville, Ohio, a son of Peter and Elizabeth McCauley Perrine,[2] and a descendant of Daniel Perrin, "The Huguenot", he worked at Lick Observatory in California from 1893 to 1909 and then was director of the Argentine National Observatory (today, Observatorio Astronómico de Córdoba)[3] in Argentina from 1909 until 1936.
Between 1900 and 1908, Perrine accompanied four eclipse expeditions and was in charge of the one sent from Lick Observatory to Sumatra in 1901. Also in 1901, he and George Ritchey observed the apparent superluminal motion in the nebulosity surrounding Nova Persei 1901.[2]
He discovered two moons of Jupiter, today known as Himalia (on December 3, 1904) and Elara (in 1905). They were simply designated "Jupiter VI" and "Jupiter VII" and were not given their present names until 1975.
Perrine co-discovered the lost periodic comet 18D/Perrine-Mrkos and several other comets. Antonín Mrkos later named the asteroid 6779 Perrine after him. The lunar crater Perrine is also named after him.
He promoted the study of astrophysics in Argentina and pushed for the construction of a large telescope (the Bosque Alegre telescope), which however was not completed until 1942 (he had retired in 1936). He remained in Argentina after retirement and died there, in Villa General Mitre (which has since been renamed to its original name of Villa del Totoral). He is buried in the Cementerio de Disidentes in the city of Córdoba.
Comets discovered or co-discovered[edit]
- C/1895 W1 (Perrine)[4]
- C/1896 C1 (Perrine-Lamp)[4]
- C/1896 V1 (Perrine)[4]
- 18D/Perrine-Mrkos
- C/1897 U1 (Perrine)[4]
- C/1898 L2 (Perrine)[4]
- C/1898 R1 (Perrine-Chofardet)[4]
- ^ "Perrine, Charles Dillon". New International Encyclopedia. 18. 1918. p. 364.
- ^ a b Leonard, John (1901). Who's Who in America, Vol. II. Chicago, Illinois: A. N. Marquis and Co. p. 885.
- ^ "Observatorio Astronómico de Córdoba". Oac.uncor.edu. September 27, 1908. Archived from the original on February 28, 2012. Retrieved February 23, 2012.
- ^ a b c d e f Kronk, Gary W. (2003). "Comet Designation Index, years 1892–1899". Cometography: A Catalog of Comets. vol. 2: 1800–1899. p. 837. ISBN 978-0521585057.
External links[edit]
- C. Perrine @ Astrophysics Data System
- Photographs taken by Charles Dillon Perrine at the Lick Observatory from the Lick Observatory Records Digital Archive, UC Santa Cruz Library's Digital Collections
- Nature 168 (1951) 409
- Popular Astronomy 59 (1951) 388
|This United States astronomer article is a stub. You can help Deep web by expanding it.
|This article about an Argentine scientist is a stub. You can help Deep web by expanding it.
- 1867 births
- 1951 deaths
- People from Steubenville, Ohio
- American people of French descent
- American astronomers
- Argentine astronomers
- American emigrants to Argentina
- 19th-century astronomers
- 20th-century astronomers
- Discoverers of comets
- Discoverers of moons
- 20th-century American scientists
- Recipients of the Lalande Prize
- American astronomer stubs
- Argentine scientist stubs


text:
buying from superpuppyshop...scam?
General discussions about Chow Chows.
Moderator: chowadmin
Post Reply
3 posts • Page 1 of 1
- Rank 0
- Posts: 1
- Joined: Sun Jun 17, 2018 1:23 pm
buying from superpuppyshop...scam?
Hi! im new here and looking to get a chow chow I fell in love with one from the superpuppyshop and I was wondering if anyone has got a pup from there thanks in advance (heres the link http://superpuppyshop.com/rita.html )
- JasonandNat
- Rank 1
- Posts: 329
- Joined: Sat May 30, 2009 4:29 am
- Location: Orleans, Ontario, Canada
Re: buying from superpuppyshop...scam?
That's a pretty cheap price for a rare breed animal. But, if your looking for love I guess it doesn't matter. Lots of rescues around as well. If your looking for purebred and reputable, perhaps a chow is out of your financial range.
Re: buying from superpuppyshop...scam?
My colleagues have been burnt before. Could either be a mix breed passing off as pure breed, or just outright scam where they take your money and disappear. If it sounds too good to be true, it probably isn't.
Max, Ritz, Shelly & Hunter
Post Reply
3 posts • Page 1 of 1


text:
Wearable devices market penetration in Japan is gearing up in health care monitoring products such as bracelet type wristwatch products with a health care function (including sensors).
Japan WEARABLE Device EXPO 2017- Invites Global Companies
Junko Nirmala for | RoboticsTomorrow
Various studies on wearable devices market have been done for decades now, mostly it was presented as a concept model until few years back, however the IOT and AI technological advances seems to be captivating large and the consumer market in an unprecedented rate.
Wearable devices market penetration in Japan is gearing up in health care monitoring products such as bracelet type wristwatch products with a health care function (including sensors). However, there are more products popping up for consumers who do not wear wrist watches.
Mr. Maezono Yuhi, The exhibitor Director says there are seeing more interests from companies of wearable devices manufacturers and services providers to exhibit at Tokyo Wearable Device Expo, as the expo is becoming as International B2B exhibition for wearable devices and their development technologies including IoT and AR/VR technologies.
Exhibitors profiles includes Components for wearable devices, IoT technologies (M2M solutions, cloud services, etc.), Wearable devices (smart watches, smart bands, etc.), Business solutions using wearable devices (logistics/fleet management, increasing productivity, etc.).
Next expo is held during 2017/01/18 - 20 at the Venue Tokyo Bigsight has more than 170 companies as exhibitors while 70% of them are domestic companies and 30% from various other countries. Visitors profile includes Wearable device manufacturers , Wearable device buyers, Corporate users such as logistics, health-care companies, Trading agents and Retailers, etc.
The reason being Japanese consumers are actively adopting to newer products from global companies so we are seeing both B2B and B2C visitors for this expo.
As wearable terminals are to be worn on a daily basis, there is a preference to emphasize the high fashion-ability leading to Prospect of other categories , products such as rings, necklaces, clothing types and other products currently in appearance and products of various shapes introduced as concept models is evolving at high speed and form a certain market.
WEARABLE EXPO Exhibition Outline
- Dates: January 18 [Wed] - 20 [Fri], 2017
- Venue: Tokyo Big Sight, Tokyo, JAPAN
- Organised by: Reed Exhibitions Japan Ltd.
- Exhibition Title: 3rd WEARABLE EXPO - Wearable Device & Technology Expo
- Official URL - http://www.wearable-expo.jp/en/
Junko Nirmala is a Tokyo resident with 17 years of Professional experience in Technology and business consulting services. Her diverse background includes Advisory assignments completed for 70 plus Japanese companies on Globalization, Founder of startup company in Green Technology, conducting Training and seminars for Global Workforce in Japan and so on. Currently she is involved in Promoting Japan Robots Industry. She has authored 3 books and consistently writes for newspapers and magazines in Japan.
The content & opinions in this article are the author's and do not necessarily represent the views of RoboticsTomorrow
Comments (0)
This post does not have any comments. Be the first to leave a comment below.
Post A Comment
You must be logged in before you can post a comment. Login now.


text:
BraveNew Named a Hot Vendor by Aragon Research in Social Collaboration and Work 2016
- BraveNew
- Aug. 3, 2016
Aragon Research notes BraveNew's ability to solve a key problem that most enterprises have with people and content: sharing knowledge.
BraveNew the integrated social collaboration platform that enables teams and organizations to share knowledge, announced today it was named a Hot Vendor in Social Collaboration and Work by Aragon Research, a leading technology research and advisory firm.
"We are delighted that BraveNew has been recognized as a Hot Vendor in Social Collaboration and Work by Aragon Research" stated Lucian Tarnowski, CEO and Founder of BraveNew. "Knowledge automation and content curation are important trends in the Fourth Industrial Revolution we are experiencing. The BraveNew platform helps our clients break down knowledge silos and create a culture of scalable learning."
According to the report "BraveNew is considered a hot vendor, because of its ability to be easily adapted to fit an enterprise's needs via its community pages and their ability to guide users to the right content and pages in an intuitive manner. BraveNew also offers clients the ability to use machine learning tools to curate contextually relevant content from across the Internet."
BraveNew's platform and communities go beyond portals and forums by adding social collaboration, extensive branding, customization and mobile access, while retaining enterprise security and tight integration with collaboration extensions.
About BraveNew
BraveNew facilitates collaborative learning by creating engaging online spaces for professional communities to share knowledge. Through Machine Learning Technology, BraveNew enables any digital content to become contextualized and collaborative. Members share, build and evolve knowledge around a common purpose whilst gaining recognition.
Press Contact: Jean McCormick
Tel: +1 310 383 6506
Aragon Research does not endorse vendors, or their products or services that are referenced in its research publications, and does not advise users to select those vendors that are rated the highest. Aragon Research publications consist of the opinions of Aragon Research and Advisory Services organization and should not be construed as statements of fact. Aragon Research provides its research publications and the information contained in them, "AS IS," without warranty of any kind.


text:
The Role
Reporting to the Sales Director, you are responsible for attending sales opportunities and driving the business to achieve sales objectives and goals.
Do you have an interest in the fashion industry?
Are you client orientated with an ability to maintain relationships?
Do you have a drive for career progression?
suituponline.com – The leading and only online mobile tailored clothing brand in Dubai. We are currently in search of ambitious individuals looking for an entry into the fashion industry.
The role is client facing at our client's locations and involves;
Guidance on colour and style selections
Taking the clients measurements for the perfect fit.
Explaining the difference between the different ranges of fabrics.
Maximizing sales opportunities with the various products available.
To explore potential markets/customers as well as maintaining existing client base
Package Includes:
Attractive Salary
Company vehicle
Benefits and bonuses
Candidates with a retail background, and regional sales experience (UAE and other GCC countries) are preferred. This is not necessary as a successful applicant will be provided with a two-week extensive training program which includes a introduction to the industry and working closely with our experienced consultants.
To meet the challenges, you should possess the following competencies:
- Good communication and presentation skills, and excellent customer service standards
- Independent worker with strong perseverance and determination to achieve revenue target
- Preferably able to start work within short notice.
Male and female applicants welcome.
A valid driving license
To Apply Click Here


text:
About the site
Search help
Facilities on the site
Ordering prints
Available for Sale
Contacts and credits
Site comments
Advanced Search
Guided tours
Today's Top 50
Latest Additions
RSS Feeds
Can you help?
Your Leodis album
Change your details
Shopping basket
Discovering Leeds
Leeds Playbills
Leodis Collections
Useful links
Results Found
Result Page
1 of 43
Search Aspect
back to search
A.R.P. Rescue Centre, group portrait of the rescue team (Killingbeck)
1940. Group portrait showing some of the members of the rescue team at the A.R.P. Rescue Centre in Selby Road. In charge of the unit is William Noel Slee who can be seen standing at the extreme left of the back row, wearing a white shirt and dark tie. Any other identifications are welcomed. The men were trained and equipped to respond to the aftermath of bombing raids during World War 2 and to rescue and evacuate casualties. Their work covered Leeds and surrounding areas but the unit was also called out to York and was in demand following the heavy bombing raids suffered by the population of Hull. The centre occupied a range of single storey buildings at the junction of Selby Road and the A.64. Although the buildings are now demolished the foundations remain. The road is now called Killingbeck Bridge.
[internal reference; 2014219_175009:LEO 7823]
A.R.P. Rescue Centre, Selby Road, training exercise (Killingbeck)
1940. Image shows a training exercise taking place at the A.R.P. (Air Raid Precaution) Rescue Centre in Selby Road. The unit was formed to act in the rescue of people in bombed areas of Leeds and surrounding districts during World War 2. It was also called out to York and, in particular Hull where there was heavy bombing. The men are demonstrating some of the rescue equipment with the aid of a dummy. In charge of the unit, and wearing a white tin hat with his hands on hips, is William Noel Slee who lived in The Fearnvilles, Leeds 8. The year after this photograph was taken, in 1941, he left the rescue unit upon being called up to serve in the R.A.F. The single storey buildings occupied by the Rescue Centre were demolished but the foundations remain. They were situated at the junction of Selby Road with the A.64. The road is now called Killingbeck Bridge.
[internal reference; 2014219_175010:LEO 7824]
A.R.P. Rescue Centre, training exercise (Killingbeck)
1940. Image shows a training exercise taking place at the A.R.P. (Air Raid Precaution) Rescue Centre in Selby Road. The demonstration is being observed by a group of invited dignitaries. The tall man wearing a dark overcoat and hat is Anthony Eden, who was Secretary of State for War in Churchill's government through much of 1940. Seen directly behind the man in the rescue harness is William Noel Slee who was in charge of the unit. He lived in the Fearnvilles, Leeds 8. On the right the man, wearing glasses and a light coloured jacket, is Maurice Tomlinson, the proprietor of J. Tomlinson & Son, builders of Bath Road, Leeds 11, and also the manager of the A.R.P. Rescue Centre. He lived on the road to Temple Newsom in Whitkirk. The single storey buildings of the Centre were demolished but the foundations still remain. The road is now known as Killingbeck Bridge.
[internal reference; 2014219_175011:LEO 7825]
Administration block for Killingbeck Smallpox Hospital under construction (Killingbeck) (3 comments)
19th April 1915 View looking southwards, showing the new Smallpox isolation ward under construction. The main block was originally the farmhouse of Killingbeck Farm to which the new extension was connected. These buildings were part of a small separate compound which became known as 'Killingbeck Smallpox Hospital' situated on the slopes of Wykebeck Valley. The compound also contained one new ward, a small mortuary and some converted farm buildings. Information supplied by John Garnett (Source: The 50th Anniversary booklet of the opening of Seacroft and Killingbeck Hospitals, 1954.)
[internal reference; 2002814_57558841:C LIM Killingbeck (1)]
Administration block for the new Smallpox ward, alterations in progress (Killingbeck)
19th April 1915. Image shows alterations in progress to the Administration block, contained within a new isolation hospital for Smallpox which included the farm buildings, a new temporary ward and a small mortuary. The Administration block had been converted from the farmhouse of Killingbeck Farm. The frontage extension was accompanied by more substantial building work at the rear of the house. The compound was distinctly separate from the nearby sanatorium. Killingbeck Sanitorium opened in 1904, originally as a Smallpox hospital, but a decision was made by the City Council, in 1912/13, to convert it to a treatment centre for Tuberculosis in accordance with the National Health Insurance Act. The building of the Smallpox isolation ward took place at the same time. The plans were approved on the condition that the main hospital, Killingbeck Sanatorium, would be vacated in the event of an epidemic of Smallpox as the new, single isolation Smallpox ward may be unable to handle the case-load. Although there was one particular outbreak of Smallpox that came close to this being put into practice, it never actually happened. The hospital closed in 1997 and the site is now a retail park. Additional information supplied by John Garnett (Source: The 50th Anniversary booklet of the opening of Seacroft and Killingbeck Hospitals, 1954.)
[internal reference; 2002814_83579654:C LIM Killingbeck (3)]
page 1
page 2
page 3
page 4
page 5
page 6
page 7
page 8
page 9
page 10
page 11
page 12
page 13
page 14
page 15
page 16
page 17
page 18
page 19
page 20
page 21
page 22
page 23
page 24
page 25
page 26
page 27
page 28
page 29
page 30
page 31
page 32
page 33
page 34
page 35
page 36
page 37
page 38
page 39
page 40
page 41
page 42
page 43


text:
Knowing how to combine sentences is essential when writing. If you were unable to properly combine sentences, each sentence would be very short, simple and boring. Unfortunately, the rules for combining sentences can be somewhat complex. This worksheet helps with some examples of sentences to combine so you can get lots of practice combining sentences.
Combine the following sentences with a coordinating conjunction (for, and, nor, but, or, yet, so).
1) She went to work. She did not want to go.
2) The scientists trained him well. They helped him find a job when his training was through.
3) Polar bears are fierce, territorial animals. Grizzly bears are the same.
4) Mark told me not to come with him. He looked longingly at me as I left.
5) I will not give in to you. I will not let you push me around.
6) He loves to drive during the day. They will let him drive before 9pm.
7) My cat was hungry. It had not eaten since breakfast.
8) They couldn't think of anything better to do. They decided to baby-sit for the family.
9) A book can be a lot of fun to read. A book can be boring.
10) That movie looks great! I would love to come see it with you.
Combine the following sentences with a subordinating conjunction (after all, although, because, before, however, therefore). This may require a semicolon!
11) They made plans to go. They ended up not being able to make it.
12) Some say that dogs are friendlier than cats. Cats can also be extremely loving.
13) What we've accomplished is a milestone. Let's raise our glasses for a toast.
14) Dr. Johnson ate a big meal. He went to work afterward.
15) I simply cannot get out of bed. I am too tired.
16) Don't give me a hard time. We've been close friends for so long.
17) We don't believe the way you do. Our culture is very different from yours.
18) I can't believe that you would do something so crazy. If I were you I might do the same.
19) The two weren't always this close. When she died, they became closer.
20) I refused to talk about it. I was put in jail.
The following sentences share either the same subject or the same verb. Combine the sentences however you can.
21) Mr. Brown walked to the store. His pet monkey Ralph walked along with him.
22) The cactus is thirsty. The cactus is not getting enough sunlight.
23) My mug was in the cupboard. My mug is no longer in the cupboard.
24) Drew's dog jumped into the air. Janine's dog jumped into the air as well.
25) The book fell to the floor. It opened to a page I had never read before.
26) Your face has scars on it. Your face looks friendly.
27) Why did you say that word? It was extremely rude.
28) Everyone is lying to me! They're trying to keep me from learning what they know.
29) Stop dancing like that. Sit back down in your chair.
30) Thomas' friends seemed so strange. They were hanging up every time they called.
Combine as many sentences as you can in the following paragraph, using the above examples to guide you.
The Boston Red Sox were three games down. The Red Sox had to win the next four games to advance. Fans were worried. Boston had not won a World Series since 1918. No team had ever come back in the playoffs from a three-game deficit. All of the fans knew this. Red Sox fans watched anxiously as the fourth game of the ALCS began. Yankees fans watched confidently. They also knew that anything could happen. People wanted to watch a good series. They did not expect it to be such a nail-biter! David Roberts stole second base. This move would be remembered as the turning point of the series. Nobody believed the Red Sox would win that year. The Red Sox won that year. The Yankees would not win the World Series for another five years. In 2009, the Yankees won the World Series.
MLA Style
APA Style
By continuing, you agree to our Terms of Use and Privacy Policy.


text:
This site uses cookies to simplify and improve your usage and experience of this website. Cookies are small text files stored on the hard drive you are using to access this website. If you ignore this message and continue without changing your browser settings, we will assume that you are consenting to our use of cookies. For further information on our use of cookies, please see our Privacy Statement.
See More
Choose your language
اختر لغتك
Your selection will be remembered for your next visit
سيذكر اختيارك لزيارتك القادمة
The wishlist has already reached the maximum number of products
The P50D is small enough to slip into a pocket and carry around. Even so, its dial scale and luminous pointer make it easy to see, even in the dark, and a new digital tuner enables simple and stable tuning.
Sorry, this product is currently not available at any of our online partners.
Sorry, unexpected issue is occurred.Please close this window and retry the purchase.
New Digital Tuner with AFCThe new Digital Tuner achieves simple tuning and stable reception. The
Auto Frequency Control (AFC) function expands the AM radio reception
range and simplifies tuning. It eliminates the need for exact tuning
precision by automatically selecting the nearest station. Noise is also
reduced* while tuning to enhance listening comfort.
*Noise is not reduced from the sounds received.
Large Dial Scale
In addition to the Large Dial Scale, which makes the frequency numbers
larger and easier to see, a Fluorescent Pointer provides comfortable viewing
in the dark. Tuning is easy even at night and during power interruptions.


text:
Sir Harry Lauder, who died at his home, Lauder Ha', Strathaven, Lanark, on Sunday will be buried beside his mother at Bent Cemetery, Hamilton, Lanarkshire, on Thursday.
Lauder took the advice he had given from scores of platforms throughout the British Commonwealth and the United States. He kept right on to the end of the road, for in his retirement good causes in Scotland had his help to the last.
He was one of the few Scottish comedians to gain international fame. His carefully studied and distinctive tricks of gesture, walk, and costume, and his mellow baritone voice were everywhere acceptable. The Scot he depicted was an odd and overwhelmingly genial fellow - a being wedded to a Balmoral bonnet and a vast crooked stick, with a fondness for tickling the lasses, rolling in the heather, and letting no friend depart without a stirrup-cup.
A friend warned him [in youth] that London did not like Scottish comedians but he had a way of flying in the face of fortune. [A London music hall manager] told Lauder frankly that he "couldn't risk" a Scottish comedian, but if Lauder would look in that afternoon he would see if there was an opening anywhere. There was.
From here on the story is the one everyone knows: world tours, enormous fees, the percolation of song after song, written and composed by Lauder, into the consciousness of the nation. This is no exaggeration: everyone knows Lauder's songs, even those who have never been in a music-hall. The public responded to him and took him into its affection in a degree unique in the story of the halls.
He gave his audiences a lot of advice, which they might regard as timely or might not. This phase became more marked during the first world war, and the public knew it was bound up with the great tragedy of Lauder's life. His boy was at Cambridge when the war came, the boy to whom he had given a thousand-pound motor-car, for whom Laudervale, the estate at Dunoon. was kept taut and trim. "I hope to see him established in the north as a decent Scots laird growing the nation's meat, and as the years go by growing the nation's men."
Captain John Lauder did not come back from France. Much that Harry Lauder had been living for died in a night in 1916, but he went indomitably on, translating his genius so far as was possible to war service. His knighthood, granted in 1919, was a tribute to his patriotism not less than to his art.


text:
My favorite Avon Campaign 20 picks
Our Fall Fashion lookbook has arrived – click descriptions to check out our fave four looks to wear now.
Triple Strand Snake-Chain Necklace
When in doubt, go Red! Our current obsession for rich lip perfection from the new Avon makeup collection is this Ultra Color Lip Crayon in Reddy for Me.
Free Direct Delivery with your $30 order. Enter FS30REP code at checkout
Easy iPhone 4/4S Sleeve Tutorial
When you are making this, please keep in mind that if you or your intended gift recipient has an iPhone 5, this sleeve won't fit. The iPhone 5 is .37″ taller than the iPhone 4/4s. Adding .75″ to the total length of the fabric piece that you cut out should compensate nicely.
Please feel free to ask any questions or leave me comments in this post! Thanks!
This sleeve will fit the iPhone 4/4S with a lightweight case. I'm assuming everyone with an iPhone 4/4S has a case on it. If you have a thicker case, then you might want to make this a bit wider – 1/4″ is enough to make a difference. If you are a rebel and don't have a case on your iPhone, then you can increase your seam allowance when you stitch up the sides.
This sleeve is supposed to fit very snugly so the phone does not fall out. Use the tab to help you slide the phone in. If you want to make it larger so it does not fit so tightly, you could add some sort of tab closure to the top to keep it from falling out.
My Avon Campaign 19 Picks – Introducing The New Avon Makeup Collection
Reveal your most color rich lips with new Ultra Color Lipstick. Infused with natural ingredients the stay true formula nourishes your lips and provides vibrant color in 3 flattering finishes. With new Ultra Color Lipstick, you can choose among 55 gorgeous true color shades designed to complement every skin tone.
Reveal gorgeous glazed lips with new Ultra Glazewear Lip Gloss. Glide on a burst of brilliant shine, drenched in rich color. The rich color you see in the tube is the same color you get on your lips with 23 color true shades in 3 fabulous finishes.
This jumbo-sized crayon combines the ease of a pencil with the coverage of a lipstick. Reveal the perfect pout with a full sweep of shimmery high-shine color. Infused with Vitamin E and Shea Butter for rich, creamy lip color and liner in one.
True Color Eyeshadow
Reveal your most alluring eyes with new True Color Eyeshadow. Discover rich, vibrant color, crease-proof wear, and shades designed for every skin tone. With True Color Technology, the rich color you see in the package is the same vibrant color you get on your eyes…with just one swipe!
- Eyeshadow Quad ►
Not sure which shade goes where? Just follow the numbers
- Eyeshadow Duo ►
Expertly paired, complementary shades in one sleek compact
- Eyeshadow Single ►
Mix and Match for your very own look
Eye Liners
Reveal your most intense eyes with new SuperShock Gel Eye Liner Pencil and Kohl Eye Liner. Create high-impact eye looks with ease.
- SuperShock Gel Liner ►
Intense gel eye liner with ease of a pencil
- Kohl Eye Liner ►
With a built-in smudger, this liner can create sultry, dramatic looks.
Reveal incredibly volumized lashes with new Mega Effects Mascara. Our first ever Wonderbrush delivers a corner to corner lash transformation. This breakthrough in mascara application provides 24-hour volume and leaves lashes darker, denser and more dramatic.
Flowers with Acorns and Lentils
What you need:
- 5″ square vase
- one box of acorn filler
- few handfuls of dried lentils
- plastic water bottle
- Exacto knife
- autumn colored flowers
Here's what you do:
- Place plastic water bottle inside square vase, centering it. Fill square vase with acorns around water bottle to determine proper height, mark.
- Remove plastic bottle and use Exacto knife to cut water bottle to marked height. Smooth cut edges with scissors, if need be.
- Center the cut bottle in square vase again, this time filling lower 1/2 inch or so of square vase with dried lentils to stabilize plastic container. Fill acorns around plastic bottle, making sure there are no gaps where the plastic bottle can be seen.
- Fill bottle with water and arrange cut flowers.
Wine Cork Key Chains
Wine Cork Key Chains
Take one cork, stack descending size washers of different colored metals to the top and bottom, and screw in an eye screw. They also look great if you simply use a screw on the bottom instead of dangling the bead. Then attach a key chain and you're done. If you want a bit of extra strength glue the washers together. Within just a few minutes you have some great stocking stuffers!
Has Your Nail Polish Turned Thick and Clumpy? Fix It With These 4 Tips
It is so much fun to amass a big collection of nail polish colors. Over the years many women create a huge collection of nail polish and have tremendous fun revisiting shades that they have not worn in quite some time.
However, many women also have the depressing moment when they open up a bottle of nail polish and see that their nail polish is now clumpy, thick and downright unusable looking.
Believe it or not, all is not lost for this bottle of nail polish! The following information is designed to teach you how to fix any clumpy nail polish you may discover in your makeup bag quickly and easily. After you learn these 4 tips you will be able to solve the issue quickly so that you can get to your manicure or pedicure right away.
1. First, Give The Bottle A Good Shake:
The first thing that you need to do is give the bottle of nail polish a good shake. Make sure that you shake it thoroughly, and that you turn the bottle completely upside down while you are shaking it to ensure that any clumps are dissolved and that anything that may have settled is blended once more.
After that, take the bottle in your palms and roll it back in forth for five or ten minutes. So long as your nail polish has not become too thick the heat from your hands may be able to thin it out considerably.
2. Mix Some Acetone Based Nail Polish Remover Into The Bottle:
The second step is to add small amount of acetone based nail polish remover into the nail polish, and then shake the nail polish slightly to mix it around.
Be sure not to overdo it, as adding too much nail polish remover can ruin your nail polish and make it unusable. Just add one or two drops at first, and see how that works.
3. Mix In A Small Amount Of Orange Oil And Acetone:
Next you can try adding a bit of orange oil and acetone to the nail polish. This has the side effect of making your nail polish smell fruity! Be sure to add equal amounts of each, and then mix them together before adding them to the nail polish. Shake, and then let it sit for at least ten minutes.
Test the bottle after at least ten minutes by taking the brush out of the bottle and seeing how thick the polish is. If it is still too thick, repeat the process until you are satisfied with the consistency.
4. Mix In A Small Amount Of Paint Thinner:
As a last resort before giving up, you can try to thin your clumpy nail polish by using paint thinner. Look for ingredients like Butyl and Ethyl Acetate and Toluene on the label of any thinner you are considering.
You can find nail polish thinners available on the market, but paint thinner will work as well.
I know it may seem like a hassle, but with the price of some polishes today, it's worth the try to me.


text:
As Chad Kingsbury watches his daughter playing in the sandbox behind their suburban Chicago house, the thought that has flashed through his mind a million times in her two years of life comes again: Chloe will never be sick.
Not, at least, with the inherited form of colon cancer that has devastated his family, killing his mother, her father and her two brothers, and that he too may face because of a genetic mutation that makes him unusually susceptible.
By subjecting Chloe to a genetic test when she was an eight-cell embryo in a petri dish, Mr. Kingsbury and his wife, Colby, were able to determine that she did not harbor the defective gene. That was the reason they selected her, from among the other embryos they had conceived through elective in vitro fertilization, to implant in her mother's uterus.
Prospective parents have been using the procedure, known as preimplantation genetic diagnosis, or P.G.D., for more than a decade to screen for genes certain to cause childhood diseases that are severe and largely untreatable.
Now a growing number of couples like the Kingsburys are crossing a new threshold for parental intervention in the genetic makeup of their offspring: They are using P.G.D. to detect a predisposition to cancers that may or may not develop later in life, and are often treatable if they do.Continue reading the main story
For most parents who have used preimplantation diagnosis, the burden of playing God has been trumped by the near certainty that diseases like cystic fibrosis and sickle cell anemia will afflict the children who carry the genetic mutation that causes them. The procedure has also been used to avoid passing on Huntington's disease, a severe neurological disease that typically does not surface until middle age but spares no one who carries the mutation that causes it.
Couples like the Kingsburys, by contrast, face an even more complex calibration. They must weigh whether their desire to prevent suffering that is not certain to occur justifies the conscious selection of an embryo and the implicit rejection of those that carry the defective gene.
As doctors and genetic counselors at leading cancer centers like Memorial Sloan-Kettering in New York start to suggest the possibility of P.G.D., more young patients are finding that their answer lies in trading natural conception for the degree of scientific control offered by the procedure. And if the growing interest in screening for cancer risk signals an expanded tolerance for genetic selection, geneticists and fertility experts say it may well be accompanied by the greater use of preimplantation diagnosis to select for characteristics that range from less serious diseases to purely matters of preference.
Already, it is possible to test embryos for an inherited form of deafness or a mild skin condition, or for a predisposition to arthritis or obesity. Some clinics test for gender. As scientists learn more about the genetic basis for inherited traits, and as people learn more about their genetic makeup, the embryo screening menu and its array of ethical dilemmas are only expected to grow.
"From a technology perspective we can test anything," said Mark Hughes, director of the Genesis Genetics Institute in Detroit, who is performing P.G.D. this month for two couples who want to avoid passing on a susceptibility to breast cancer. "The issue becomes what is considered serious enough to warrant such testing and who decides that."
The process is also difficult and expensive. P.G.D., which requires in vitro fertilization, can cost tens of thousands of dollars. While insurance companies often pay for the more traditional uses of the procedure, they have not done so for cancer-risk genes, fertility experts say. The barrier to affordability, some critics fear, could make preimplantation diagnosis for cancer risk the first significant step toward a genetic class divide in which the wealthy will become more genetically pure than the poor.
Knowing that Mr. Kingsbury had tested positive for the colon cancer mutation, the Kingsburys started with the basic laws of genetics: because children randomly inherit half of each parent's genes, he had a 50 percent chance of passing it on. Since the mutation raises the risk of developing the cancer by about twentyfold, that means any child of theirs conceived the traditional way would have about a one in three chance of getting it, usually around age 45. Those who did develop the cancer would also have a nearly 90 percent chance of surviving it, but only if it was caught early.
The jumble of odds meant little to the Kingsburys as they tried to think about starting a family while the cancer claimed Mr. Kingsbury's second uncle. Then, from a cousin of Mr. Kingsbury's who had also fought colon cancer, they heard about P.G.D., the technology that offered them a way to reload the genetic dice.
To do it, they had to overcome their own misgivings about meddling with nature. They had to listen to the religious concerns of Mr. Kingsbury's family and to the insistence of Ms. Kingsbury's that the expense and physical demands of in vitro fertilization were not worth it, given that the couple could probably get pregnant without it. They had to stop asking themselves the unanswerable question of whether a cure would be found by the time their child grew up.
It took them two months to make the decision. But every time Mr. Kingsbury looks at Chloe, with her blue saucer eyes and her tantrums that turn abruptly to laughter — and back — he knows it was worth it.
"I couldn't imagine them telling me my daughter has cancer," he said, "when I could have stopped it."
Shifting Medical Advice
Cancer-prone families are only just beginning to hear about P.G.D. in part because the procedure falls through the cracks in medicine. Oncologists tend not to think about family planning, and obstetricians tend not to think about cancer genetics. Doctors may also shy from raising the prospect of what some critics call "unnatural selection."
For many couples, going to such lengths to ensure that a child will be born free of a predisposition to a certain kind of cancer is anathema. Breast and colon cancer, the two most common cancers for which genetic susceptibility tests are available, can be detected early and are often treatable, and even those who die of them often lead long and productive lives.
Many people without the risk-raising genes still get one of the cancers, and those who do carry the genetic mutations are just as likely as anyone else to develop other forms of the disease.
Prospective parents who want to avail themselves of P.G.D. must first undergo the same in vitro fertilization process often used to assist infertile couples, in which eggs are extracted from the mother and fertilized with the father's sperm in a petri dish. When the resulting embryos are three days old, doctors remove a single cell from each and analyze its DNA. Only embryos without the defective gene are then considered candidates to implant in the mother's uterus.
The out-of-pocket costs often exceed $25,000, depending on how many in vitro cycles are required. Because embryos are selected for their genetic status, rather than solely by which look the healthiest, the chance that they will fail to develop after implantation is higher. And despite the birth of thousands of apparently healthy babies after P.G.D., there is still concern that the long-term effects of removing a cell from an eight-cell embryo have not been studied enough.
That has not stemmed the rising demand to screen embryos for cancer-risk genes. No one tracks the number of such procedures in the United States, but an article in next month's issue of The Journal of Clinical Oncology reports that clinics around the country have been quietly performing P.G.D. for hereditary cancers of the breast and the colon. The article, written by Dr. Kenneth Offit, chief of clinical genetics at Memorial Sloan-Kettering Cancer Center, suggests there would be even more interest in P.G.D. if oncologists were to begin informing prospective patients of the option.
About one in every 200 Americans carry a genetic mutation that makes them more susceptible to breast or colon cancer. The half-million or so who carry mutations in several genes associated with colon cancer have up to a 70 percent chance of developing the disease, compared with 6 percent for those with normal copies of the genes. One in eight American women will develop breast cancer in their lifetimes, but for those who carry mutant forms of the BRCA1 or BRCA2 genes, the risk jumps to one in two.
Until the last year or so, Dr. Offit said in an interview, he questioned the utility of P.G.D. for his patients, focusing instead on the increasingly effective prevention and treatment options for anyone born with an elevated cancer risk. Genetics, he said, is not necessarily destiny.
But learning of its existence, Dr. Offit noticed, could make many young patients less fatalistic about their genes and more optimistic about starting a family. The sense of relief it offered was especially strong among those who had seen a parent or a sibling die of cancer.
"Having seen so many children from cancer-prone families, I'm more sensitive to the sentiment that they would rather avoid the syndrome altogether," Dr. Offit said. "Our genetic counselors now try to bring up the potential of this technology in circumstances where we think it may be empowering to young couples."
Too Late for Some Carriers
If other cancer centers follow Sloan-Kettering's lead, the shift will still come too late for some cancer gene carriers. One woman, a professional in New York, said she blamed bad medical advice for her having possibly passed to her 4-year-old daughter a chance of developing breast cancer this is five times as great as that of women in the general population.
Unaware of P.G.D., she followed the counsel given to most women with a family history of breast cancer and had her children before getting tested for the gene. The logic is that women ought not worry about their genetic status until they can consider the most effective prophylactic measures, removing their breasts and ovaries.
But in postings to an online breast cancer support group, facingourrisk.org, the woman said she suspected that the prevailing unease over genetic selection and the question of when life begins also kept doctors from suggesting P.G.D.
"Those values should not be dictating recommendations by doctors," said the woman, 40, who declined to be identified by name because her words might be hurtful to her family. "That's what I resent. I feel like the choice was taken away from me."
In Europe, divergent values are quite explicitly shaping different P.G.D. policies. This spring, England approved the use of preimplantation diagnosis for the breast and colon cancer risk genes. In Italy, the procedure has been effectively banned for any condition.
In the United States, where the technology is not regulated, decisions about when it is appropriate are left largely to fertility specialists and their patients. Reflecting the growing demand for the procedure, the company that owns the tests for the breast cancer genes recently licensed the right to use them to three fertility centers.
"We decided we don't want to do it here," said William Hockett, a spokesman for the company, Myriad Genetics of Salt Lake City, citing both moral preferences and a disinclination to invest in the technique for business reasons. "But we don't want to impose our values on society, so we felt we should allow others to do it if they wished."
The interest in embryo testing is being driven largely by a greater knowledge of genetics among cancer patients and their family members. In the last five years, nearly 10 times as many Americans have been tested for the breast-cancer-risk genes as in the previous five, according to Myriad, surpassing a total of 100,000 since the test was made available in 1996.
Familiarity with their own genetic profile makes some people more comfortable with intervening to alter their children's. For them, genetic traits can seem less like destiny and more like any other part of their lives that can be improved by technology.
Many of those exploring P.G.D. are the first generation of women to have reached reproductive age after their mothers developed cancer and tested positive for one of the breast cancer mutations. They see it as saving not just their children but generations of descendants from the same fate.
"I was very relieved to know that I would not have to pass this gene on to my children," said Michaela Walsh, 20, a junior at Susquehanna University in Selinsgrove, Pa., who found out she carries a BRCA mutation. She has already decided she wants to use P.G.D. when she has children. "My mother told me that the only worse thing than having cancer twice was having to give the gene to me."
But the same knowledge makes others who carry the mutations take particular offense at the selection procedure, which they say implies that they themselves, and many members of their family, should never have existed. It raises the specter of eugenics, they say, in the most personal terms.
"It's like children are admitted to a family only if they pass the test," said Denise Toeckes, 32, a teacher who tested positive for a BRCA mutation. "It's like, 'If you have a gene, we don't want you; if you have the potential to develop cancer, you can't be in our family.' "
Other critics oppose preimplantation diagnosis on the grounds that it could be used to select against homosexuals, women or people with disabilities. It reduces people to their genes, they say, and paves the way for the pursuit of children designed to suit parental ideals and for discrimination against those born with perceived imperfections.
Proponents of the technology say that confusing the concept of "designer babies" with people trying to avoid deadly illnesses is hurtful and misleading. No one, they say, would endure the substantial physical and emotional difficulty posed by the process to make a baby with blue eyes and a wicked curveball. Still, the hostility couples have encountered from friends, family, colleagues and even medical professionals caused several of those interviewed for this article to request that their names be withheld.
One prospective father, a medical resident at Johns Hopkins Hospital in Maryland, said the Shady Grove Fertility Center, the local fertility clinic, required that he and his wife, also a resident at Hopkins, write a letter justifying their request for P.G.D. to the clinic's ethics committee.
The doctor's own father continually warned that in trying to prevent cancer, removing a cell from the embryo would create a mentally retarded child — no matter how many times his son cited studies to the contrary. Reactions from colleagues made the couple worry that if they allowed their names to be used, it might hurt their chances when applying for jobs at medical or research institutions.
"It became such a negative topic of conversation that my wife and I decided, 'We're not talking about this to anyone,' " said the doctor, 30, whose mother has had her breasts, uterus and ovaries removed to combat her cancer, in addition to undergoing dozens of chemotherapy sessions.
The couple held firm in their belief that there was no virtue in letting nature take its course when its outcome was so potentially damaging. "We hope to look back on this as really the first decision we made as parents," they wrote in a letter to the ethics committee that persuaded the clinic to let them move ahead.
Multiplying Decisions
Even for those who choose it, the burden of selection weighs heavily. Kim Surkan, who carries the BRCA1 breast cancer mutation, said her partner had initially described preimplantation diagnosis as a "pact with the devil." As Ms. Surkan prepares for her eggs to be extracted next month, she has nightmares that the child she selects will drown in a swimming pool, as opposed to a child chosen by fate, who might carry the cancer-risk gene but would have been a good swimmer.
"At least I know I've done whatever I can do with the information I have," said Ms. Surkan, an adjunct lecturer in women's studies at the Massachusetts Institute of Technology. "I can't control everything."
Like many people who want to take advantage of P.G.D. but cannot easily afford it, Ms. Surkan had to first convince her insurance company that she was infertile so that it would pay for the in vitro fertilization process. Because she is in a same-sex couple, that meant she had to undergo several cycles of insemination, hoping that she would in fact not get pregnant, so that she could proceed with preimplantation diagnosis.
Now more decisions are coming. What if, she wonders, she is unlucky, and all her embryos have disease genes? Should she implant a male one, since men rarely develop breast cancer, even if she is opposed to selection based on gender?
If she does get pregnant with an embryo found to be free of the gene, should she test the fetus at 16 weeks, since there is up to a 3 percent chance that P.G.D. will fail to detect an unwanted mutation? If she has two embryos implanted, and one has the defective gene, should she terminate it?
For many couples, preimplantation diagnosis is an appealing option precisely because it does not require terminating a pregnancy, a step that is common after an amniocentesis reveals that a fetus has a severe genetic disease but is essentially unheard of for predisposition to common cancers.
Danielle Jamond, who carries a gene for a severe form of inherited colon cancer, said she and her husband were considering that option a year ago. But she was saved from making the choice when she heard of a doctor who had developed a P.G.D. procedure for her form of the disease.
"At that point, the choice was obvious," said Ms. Jamond, a human resources manager in a suburb of Paris, who has had her large intestines removed to avoid getting the cancer, a prophylactic measure for people with her genetic mutation.
Four embryos were created from her 12 eggs, and three did not have the genetic mutation. One died, the other two were implanted, and one survived. She is now six months pregnant with the surviving one, a girl.
But some people who believe life begins with conception think P.G.D. is as unethical as abortion and perhaps more pernicious because it is psychologically less burdensome. Unused embryos may be frozen indefinitely, skirting one moral issue, but at a cost of several hundred dollars a year. Reproductive Genetics Institute, a leading P.G.D. lab in Chicago that performed the preimplantation diagnosis for the Kingsburys, said about half the embryos containing the unwanted genetic profile were discarded and half donated to research.
'Is This Genetic Engineering?'
Already, thousands of couples who are undergoing in vitro fertilization to overcome infertility use P.G.D. to weed out embryos that harbor common chromosomal disorders that would otherwise be screened for by amniocentesis. Fertility experts say they may be the first to take advantage of the procedure for a range of other genetic conditions.
Dr. Ina N. Cholst, a reproductive endocrinologist at Weill Medical College of Cornell University, said a fertility patient of hers who suffers from an inherited arthritic condition called ankylosing spondylitis was planning to add genetic diagnosis to her in vitro procedure. She has a 50 percent chance of passing the gene to a child. Of those who carry it, four of five will be unaffected. The others will have arthritis, sometimes mild and sometimes quite severe, but increasingly treatable.
"We brought it up," said Dr. Cholst, who consulted with the patient's rheumatologist. "At the same time, I am thinking, 'Is this a wonderful thing, or is this genetic engineering?' "
In the future, many specialists believe, most in vitro fertilizations will be performed for fertile couples seeking genetic diagnosis, not as a treatment for infertility. But as it becomes easier to identify the possible consequences of more kinds of genes, the decisions for parents may become harder. Having passed over 4 embryos with the defective gene and identified 10 healthy ones, the Kingsburys were asked if they wanted to pay $2,000 extra to test them for Down syndrome. That test eliminated two more.
"You kind of feel like you shouldn't be doing it," Ms. Kingsbury said. "But then why would we go through all of this and not take those extra precautions?"
Soon, experts say, prospective parents may be able to choose between an embryo that could become a child with a lower risk of colon cancer who is likely to be fat, or one who is likely to be thin but has a slightly elevated risk of Alzheimer's, or a boy likely to be short with low cholesterol but a significant risk of Parkinson's, or a girl likely to be tall with a moderate risk of diabetes.
For the Kingsburys, the choice is still clear. Like any parents, they plan to tell Chloe the story of her birth. And if all goes well, they say, she will soon have a sibling who shares a similar tale.Continue reading the main story


text:
If you have been injured due to the carelessness or negligence of another person, business or organization, you have the right to pursue monetary compensation for your loss.
Unfortunately, obtaining fair compensation is often an uphill battle. Insurance companies limit and deny compensation to make a profit. This is why it is so important to have an experienced and highly rated personal injury lawyer fighting for you.
At the Law Offices of Dan Lyons & Associates in West Haven, we are always willing to bring the fight to the insurance companies. We are skilled negotiators and experienced litigators with more than 30 years experience. If an insurance company does not treat our client fairly, we have the training, skill and experience to take any case to court.
Full-Service Personal Injury Law Firm
We handle a broad range of personal injury claims, including those arising from:
- Motor vehicle accidents: Including car, truck, motorcycle, bicycle, pedestrian and other accident claims
- Medical malpractice: Handling claims involving birth injuries, surgical errors, medical errors, nurse malpractice and other forms of medical negligence
- Slip-and-fall accidents: Accidents caused by cracks, potholes, slippery surfaces and other unsafe building conditions
The law allows you to pursue compensation for medical bills, wage loss, pain and suffering, and other hardships you have suffered due to this accident. Our firm has the experience, skill and resources to help you maximize your recovery.
We represent injury victims as well as family members who have lost loved ones in fatal accidents.
Learn More From A Highly Rated Attorney
If you have suffered a serious personal injury in Connecticut and are seeking effective representation, we are here for you. Call us today at 203-901-1230 or contact us online to arrange your free initial consultation.


text:
Manager's Specials at Toyota of Muncie
Ready to take home a new Toyota vehicle? Take a look at the new car specials offered at Toyota of Muncie. By taking advantage of these ever-changing specials, you can guarantee a phenomenal price on your future Toyota model. Be sure to check out our Toyota finance specials to save even more. Call us or contact Toyota of Muncie for more information or stop by our nearby Toyota dealership to view our brand new 2018 Toyota inventory.
Please speak with our trade advisor for more information.