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by (in order of who spoke up first) Bryce (age 11), Michele (age 10), Oliver (age 10), Wiley (age 11), Clint, (age 11), Quinn (age 12) and ZeBot Zebra (age infinity – kitchen creds at zebot.org)
We're baking up amazing things here in Silver Spring – and we want to share our expert kitchen observations and insights with you!
We think the best things about baking are:
The fun of making everything ourselves
Stirring ingredients and watching batter come together
Tasting different flavors and textures
Being proud that everything is really homemade
Not having to buy muffins and scones at the store
Eating all the great things we baked ourselves
Our families and friends enjoying the special things we bake
Here are a few of our favorite baking secrets:
Being creative is cool. You can customize recipes with your favorite flavors. Just for fun, we added a little bit of freshly grated orange zest to our scones. (We were snacking on oranges and thought it would be interesting to mix them into the batter we were making). When the scones were baked, the bright, fruity flavor perfectly complemented the crunchy sweetness of the caramelized topping.
Measuring is a science. You would think you could just scoop out flour with the measuring cup, but it turns out that's not the best way to do it. Chef Sheila said that when you dip a measuring cup into a tin of flour, it compacts the flour and actually increases the weight relative to the amount of space it fills (so your measurements are a little bit off), which means your baked creations won't have a light, fluffy texture. Instead, use a spoon to over-fill your measuring cup, then level it off with a straight edge like a bench scraper or wooden spoon.
Mixing is an art. When we were stirring, we realized how important it is to move the spoon across the bottom of the bowl and all the way through the batter, turning and folding so that all ingredients get completely mixed in. Otherwise you can have big lumps of flour or clumps of zucchini or other goopy stuff messing up your recipe! Little lumps of flour are okay in muffins–it's important not to over mix. If you over mix, you'll see tunnels in your muffins, and the top will look like an exploded volcano.
It's fun to talk while you bake. We learned lots of interesting stuff from each other – like what people's favorite flavors are, what our fellow cooks' cats and dogs look like (please see below), and that avocados (which were in the fruit bowl next to ripe pears) are also known as alligator pears. In general, it was a great example of creative collaboration!
Teamwork is important. One of the best things about teaming up with other cooks is that everyone can take charge of a different task to make sure things get done properly and on schedule. It's great that one cook can be measuring or stirring while someone else is keeping an eye on what's baking in the oven.
Baking details are important. Here are some examples: Using a silicone baking mat helps your scone topping brown and caramelize perfectly without sticking to the baking sheet. A mini scoop makes it easy to put equal amounts of batter into each well of a muffin pan. And if you spray the top of your muffin pans with a nonstick baking spray, you can easily remove the baked muffins before they've totally cooled.
Hungry for more creative kitchen inspiration? Stay tuned – we'll be back soon!
Click here for the recipe for Oatmeal Currant Scones and here for Double Chocolate Zucchini Muffins.


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TONGUE RIVER LADY EAGLES BASKETBALL - The Tongue River Lady Eagles open the 2-A state tournament tomorrow at 10:30 against Wyoming Indian.
Coming into the season Head coach Diane Moser knew she would have an inexperienced team with the lone senior being Kim Caywood who has been a great leader for the Lady Eagles and Moser says it's been fun to see this team get better and better every week.
And that play continued last week in the regional tournament.
They open with Wyoming Indian tomorrow as Moser talks about what the Lady Eagles need to accomplish this week to be successful in the tournament.
Again the Lady Eagles lead off our live coverage of the state 2-A basketball championships they play Wyoming Indian at 10:30 tomorrow morning and you can hear the game live on AM 14-10 KWYO.
BIG HORN RAMS / LADY RAMS BASKETBALL - The Big Horn basketball teams head to state tomorrow. The Rams open against Rocky Mountain we will have it live on AM 14-10 KWYO at noon.
The Lady Rams face Greybull in their opener at 6:00 that game will be live on our sister station 95.9 fm.
4-A EAST REGIONAL BASKETBALL - The Broncs will play Casper Kelly Walsh tomorrow night at 5:30 in the 4-A at Sheridan high school. that game will be broadcast live on AM 14-10 KWYO.
The lady broncs have a first round bye and will play Friday night at 7:00 in the semi finals they will play the winner of the play-in game between Cheyenne East and Cheyenne Central.
If the Broncs get by KW tomorrow they will play a double header with the Lady Broncs Friday the Broncs will at 5:30 with the girls at 7:00
Here's the schedule for the first day of action tomorrow in the 4-A east regional tournament at Sheridan high school.
The East / Central girls game will tip at 4:00 followed by the Broncs and Kelly Walsh at 5:30. In the girls bracket Laramie plays Kelly Walsh at 7:00 and the late game tomorrow at 8:30 will have the match-up between The East / Central boys.
Friday's game time schedule is the same as tomorrow 4:00, 5:30, 7:00 and 8:30. As we move through each tournament we will have each days schedule posted on the sports page here at Sheridanmedia.com
WYOMING BASKETBALL - The Wyoming Cowboys played San Diego state last night. the Aztecs took the game 85-58 it was the final home game of the season for the Pokes.
They close out the regular season on the road Saturday afternoon at BYU we will have the game live for you on AM 14-10 KWYO. Broadcast time is 1:00 with the tip at 1:30.
INDOOR TRACK AND FIELD - The Bronc and Lady Bronc indoor track teams will end the indoor season Friday and Saturday at the state indoor championships in Gillette.

subset: commoncrawl


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Pray for your neighborhood … change your neighborhood!
A friend has written a free e-book to help you focus a month of short prayers on changing your neighborhood. I encourage you to use one of the following three versions with your prayer network:
Joy of the Harvest: Praying for Your Neighborhood,
Joy of the Harvest: Praying for our School Children or
El gozo de orar por su vecindad y la cosecha de Dios en ella.
Other prayer resources
CityPrayer – use the Lord's prayer to pray for your city.


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Oil contractors ring fence: the effect of the ring fence
Part 8ZA provides for a contractors ring fence which works in a similar way to the existing production ring fence (see OT21000).
CTA2010\S356M provides that if oil contractor activities are carried on then they are treated as a separate trade. Where there is composite trade partly of contractor ring fence elements and partly of elements outside the contractor ring fence, then the contractor ring fence profits and profits arising from activity falling outside the contractor ring fence, must be calculated separately.
Oil contractor activities has a specified meaning provided by CTA2010\S356L, which essentially covers activities which include the use of a leased relevant asset to which the new hire cap would apply (see OT50005).
The effect of the contractors ring fence is to prevent expenses and reliefs which are not attributable to the oil contractor activities from reducing those profits. Where a company is the subject of both the contractors ring fence and the production ring fence, these restrictions apply independently and it is not possible to relieve losses made in one ring fence against profits made in the other.
Restriction on losses CTA2010\S356NE
CTA2010\356NE provides that losses made by a contractor on activities outside the Contractor ring fence (Contractor NRF losses) are not allowed against contractor ring fence profits (contractor RF profits) for the purposes of CTA2010\S37.
However, there is no restriction on the use of contractor ring fence losses (contractor RF losses). These can be carried back and allowed generally against profits including profits arising outside the contractor ring fence.
Contractor RF losses can also be carried forward and set against subsequent contractor RF profits.
If a loss arising outside the contractor ring fence is carried forward (contractor NRF loss), it can only be utilised against profits outside the contractor ring fence in a subsequent accounting period.
Subject to the rules which stream the losses inside and outside the contractor ring fence, Contractor NRF losses will be subject to the normal rules relating to trade cessation and succession.
Restriction on Management expenses CTA2010\S356ND
Expenses of management are not allowable against contractor ring fence profits.
Restriction on Group Relief CTA2010\S356NF
Under CTA2010\S356NF(1) group relief is to be allowed against the claimant company's contractor ring fence profits only to the extent that the loss surrendered arises from contractor ring fence activities.
CTA2010\S356NF(2) ensures that where a company has a contractors ring fence profit and a loss arising outside the contractor ring fence, the company may surrender the contractor NRF loss to another company outside the contractor ring fence which is a member of the same group.
As with the production ring fence, it is not possible to reduce profits within the contractor ring fence completely by means of group relief, where there are charitable donations subject to CTA2010\S189
Restriction on Capital Allowances
Capital allowances under CAA2001\S259 or CAA2001\2S60 (special leasing, see CA20040) cannot be claimed inside the contractor ring fence.
Restriction on Loan relationship credits and debits CTA2010\S356NB
CTA2010\S356NB allows a deduction for interest against contractor ring fence profits only if the money borrowed is used to meet expenditure incurred in carrying on oil contractor activities or is appropriated to meet such expenditure. These restrictions apply whether the borrowing is from an associated person or not. The section applies only to a company with contractor ring fence profits.
CTA2010\S356NB(2) allows a deduction against contractor ring fence profits for loan relationship debits to the extent that the loan relationship is in respect of "money borrowed" that has been "used to meet" expenditure incurred by the company on oil contractor activities. The legislation parallels that in place for the production ring fence. The guidance at OT22000 applies to the terms used.
Exchange losses can be deducted from contractor ring fence profits only to the extent they arise on money debts on which interest payments would be allowed as contractors ring fence deductions.
Exchange gains arising in similar circumstances are treated as loan relationship credits and included in the contractor ring fence profits (CTA2010\S356NC).


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Time to time something happens to me to deviate from my topic Project Management. Today I experienced something which I have never experienced in my life before..
There is a sub power plant 4-5 houses away from my home. Around 2AM today morning there was a huge noise of a blast and our house vibrated for a moment and electricity went off. I couldn't realize what was happening. But I have experienced bomb blasts before and I thought it must be one.. But never faced it this closer before.. I was wondering where it could be... …And then one of our neighbor friends called and said his house ceiling is damaged due to vibration and definitely it should be a bomb. So there was no power till the morning. No TV No news to check what it was..
Early morning I heard from our caretaker that the blast has taken place in the power plant closer to home. He has got to know from somebody around the area. Any way I had to get in to the office on time due to a meeting scheduled with an important customer.. But when I came out of the house only I realized that the road is closed and I had to take a different route to the main road. How ever due to my delay I couldn't make it to the meeting
Till Morning they didn't confirm it's a LTTE terrorist attack and investigations were going on. But I saw in a web site just now., that its confirmed as a LTTE attack.
Its very sad that these incidence happen frequently which really disturb civilians lives. Lately there were bombs in 2 buses and lots of innocent civilians died.
So no matter from which part of the world they are.. Terrorism is bad.. Stop Funding Terrorism.. Directly or indirectly….Because tomorrow they can take your loved ones away from you…


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Real World article
(written from a Production point of view)
(written from a Production point of view)
|Jake Kilfoyle
|United States
Jake Kilfoyle is the Hawaii-based parachutist and stuntman who performed the underwater stunt of Charlie showing a new message and breaking the window during Hurley's vision in "The Beginning of the End", and is featured performing this stunt in the Official Lost Podcast on February 04, 2008(link) following the broadcast of this episode.
External links
- Discovery Channel: Stunt Junkies - bio for "shark swoop" stunt
- Hawaii Skydiving -newsletter that mentions Kilfoyle is an instructor at Skydive Hawaii and placed in a 2007 Pro Swooping Tour event
- 808x Extreme Sports - photo gallery marked with tag "Jake Kilfoyle"
- "Experiencing Hawaii from Above"
- Honolulu Star-Bulletin - May 21, 2007
Charlie stunt double Jake Kilfoyle performing the underwater portion of Hurley's vision from "The Beginning of the End". The camera is visible at bottom left. (Feb. 4, 2008 Official Lost Podcast [1])
Community content is available under CC BY-NC-ND unless otherwise noted.


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Vesak (Vesākha, Wesak) was celebrated last week by many Buddhists around the world. It is believed to be the day on which the Buddha was born, the day he attained enlightenment and the day that his physical body died. Same date, different years.
My friend, Venerable Bellanwila Wimalarathana, is the chief incumbent of Bellanwila Rajamaha Viharaya in Colombo, Sri Lanka. He is also a member of the Asian Human Rights Commission, a regional non-governmental organisation that monitors human rights in Asia, documents violations and advocates for justice and institutional reform to ensure the protection and promotion of these rights. The Hong Kong-based group was founded in 1984.
Bishop Duleep Kamil De Chickera is the 14th Anglican Bishop of Colombo, Sri Lanka and is also a member of AHRC.
Ven. Bellanwila Wimalarathana wrote a letter to Christians on his understanding of Christ at Christmas last year prompting Bishop Duleep Kamil De Chickera to reciprocate with this letter to Buddhists at Wesak.
His retelling of the Buddha's message of compassion, respect and coexistence is worthy, I thought, of a broader audience so I'm passing it along to you.
An Open Letter from Bishop Duleep De Chickera to the Buddhists of Sri Lanka Forwarded By the Asian Human Rights Commission (AHRC)
A seekers vision
I write in my personal capacity as a disciple of Christ, a student of Buddhism and one who perceives the universal wisdom and values in world religions as gifts for all and not just the adherents of a respective religion.
This is not an attempt to teach you what you know better than I; but an expression of my profound respect for the Buddha and the potential I see in the Dhamma for compassion, contentment and coexistence for all life. I know you will be patient with any shortcomings in my perception of Buddhism.
Compassion for all life
I have never ceased to be stirred by the Buddha's compassion for all living beings; and not humans only. This all inclusive compassion makes sense, since compassion for humans only, if accompanied with disrespect for other forms of life upsets the balance in an interdependent life system. Consequently compassion for humans only, is short sighted and counter-productive; it inevitably induces chaos for all forms of life, including humans.
Within this wider framework however this teaching has a direct impact on critical human relations such as ethnic discrimination, inter-religious tensions, economic injustice, political intolerance and the collapse of ethical norms that we wrestle with today. Since compassion according to the Buddha is never selective and will not endorse divisive and oppressive systems, it is full of potential to transform these exclusive and destructive trends into a just and integrated system for all life.
Liberation from Tanha
From my early adult days I have found the Buddha's analysis of the cycle of life in the four noble truths, most enlightening. His discernment of Tanha as the cause of suffering is a precise explanation of the human dilemma. The inordinate greed for power, dominance, wealth and material resources that motivate many, leads to aggression, suppression and suffering which eventually destroys all; the greedy, the content and Mother Earth.
The objective of life is consequently to overcome Tanha. This path ranges from the simple life style, which demonstrates contentment; to detachment, that state of selflessness which rises above the enticement of the market, the arsenal and a false sense of prestige and is undoubtedly a sign of true liberation.
The fullest manifestation of selfless detachment is demonstrated in total renunciation; the ability to point to the way by getting out of the way. This profound insight into self-emptying is an indispensible lens for personal and social evaluation which our leaders and people cannot afford to ignore.
The Wisdom of Ahimsa
That the Dhamma is received through self-realisation and bears fruit in Ahimsa, (transforming non-violence) safeguards personal privacy and prevents social aggression. Just as the Dhamma cannot be subject to force or manipulation to bring enlightenment, recipients of the Dhamma cannot indulge in these tendencies and to the contrary strive to overcome them. This, in my understanding, is how surrounding forms of life are respected and the Dhamma shared with dignity in ever widening circles.
This refreshing option to violence is undoubtedly one of the reasons that has made Buddhism a world religion. Consequently it is those who are the vehicles of this enlightened, non-violent and compassionate teaching who will continue to sustain and commend Buddhism today.
May the Dhamma of the Compassionate One, shed enlightenment and emancipate our beloved Sri Lanka from greed and violence.
With Peace and Blessings to all living beings.
Bishop Duleep de Chickera
Wesak 2013


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A primary goal of Postural Restoration® is to achieve and maintain a solid Zone of Apposition while achieving tri-planar movement.
In plain English, this means that your body can move in all three planes of motion: sagittal (front to back), frontal (side to side), and transverse (rotation), while keeping your rib cage positioned correctly.
Examine the pictures below. There are two big differences between me and my two clients. Visually, you'll see my left hip is completely off the bench. Theirs are not.
Pelvic strength and the ability to establish and maintain a left Zone of Apposition during dynamic movement, is the difference.
You can stop the slide show on any particular picture by positioning your cursor on the picture.
The Zone of Apposition
The zone of apposition is the area from the inside of the bottom ribs, where the diaphragm attaches, to the top of the diaphragm. If the ZOA is present, the diaphragms will be nicely dome shaped and enable proper diaphragmatic breathing. The following pictures show what a ZOA is, an optimal ZOA, and a suboptimal ZOA. Placing your cursor on any of the pictures will stop if from changing to the next one.
The first picture shows the ZOA. Notice it is referring to the vertical area that starts at the bottom of the ribs and extends up to the top of the dome of the diaphragm. In it's natural state it should be domed, like in this picture.
The next picture shows an optimal ZOA. You will notice the domed shaped diaphragm. If you can attain this ZOA, it means your lower back will be in a truly neutral position, your abdominal muscles truly engaged, and your diaphragms truly working. I say truly because most people believe they are maintaining a neutral spine, believe they are engaging their abdominals, and believe they are diaphramatically breathing, but they are not because their biomechanics dictate that this can't be the case. Unfortunately, the vast majority of us will look like the next picture.
In the third picture the diaphragm has lost its nice dome shape. It has become much flatter. This is because the ribs are raised in front (and almost always have a left pelvis rotated forward) . When the ribs rise, and never come back down fully, you lose your ZOA because you are now living with your ribs up. This position ensures that your lower back is over-arched (extended), your abs are not positioned to engage correctly, and your diaphragms can't pump.
"Ribs up" occurs with inhalation and rotational movements of the torso (rotate your torso to the right and the right ribs should rotate up while left go down, rotate left and the left ribs rotate up and right ribs down).
When the ribs stay up, and never rotate down fully, it becomes a problem because the diaphragm now loses its dome shape and isn't in a good position to help you breathe.
The ribs should move up (and out) during inhalation, and come down (and in) upon exhalation. But this doesn't always happen.
This "ribs up" position, and loss of ZOA, can occur on both sides or more frequently, just on the left side.
And the Point is?
If the ZOA is lost, it means that some muscles are no longer doing their jobs correctly and other muscles will kick in to help out. This is what we call compensations. We can live with compensations, but we'd rather not have to, because eventually the body won't be able to compensate any longer and the body will change the way it works, and generally not for the better.
In a somewhat existential sense, when the compensations become too great, it's like you are living in a different body. Bones have changed position, muscles have changed position and function. Breathing patterns have changed. Humans evolved to meet the demands of life in one way, but we have changed. Yet the demands of human life are the same. Something has got to give.
I lived for years with a body that could no longer compensate and was in constant pain. It was horrible and depressing.
The Left Internal Obliques
The zone of apposition and the pelvis are the core of the human body. Together, they permit true tri-planar movement. If the zone of apposition is lost, so too will true tri-planar movement.
This is not to say that you will no longer be able to move your arms, legs, thorax, and neck. It just means they won't move as fully or as effortlessly as they would if you had full control over your zone of apposition. A proper ZOA ensures that your thorax and pelvis are stable enough to permit limbs to move easily and powerfully.
The picture to the right shows, chiefly, the left internal obliques. What you will notice is its rather large area and most importantly, where the obliques attach
These attachment sites relate to the zone of apposition because they move the ribs down and rotate them to the left, thereby ensuring the integrity of the ZOA.
They also prevent the ribs from excessively elevating and rotating right during breathing and any movement that requires rotational movement of the torso, such as walking.
So not only do the internal obliques move the rib cage to the same side, they also prevent excessive movement when the movement is going to the opposite side.
The left internal obliques (and the transverse abdominis which lay underneath) help maintain your ZOA.
Without left internal oblique and pelvic strength I wouldn't have been able to what I did in the test pictured in the beginning of the post.
When the left internal obliques lose the ability to
- Bring the ribs down.
- Prevent the left rib cage from rising excessively during movement and breathing,
- Hold the left ribs down while rotating to the right
You have lost your ZOA.
In the picture to the right, you will see what this loss of zone of apposition actually looks like in my 13 year old niece. I have labeled the rather prominent and elevated left ribs. This is what happens when the left internal obliques can no longer hold the left ribs down towards the pelvis, even at rest.
The Compensation System
A loss of ZOA is part of an overall compensation system that produces compensational movement of the feet, legs, pelvis, rib cage, arms, neck, and head.
If you examine the ZOA diagrams again, with a loss of ZOA you'll find:
- A lower lumbar spine with increased lordosis (the natural curve in your lower back).
- A middle back (thoracic spine) that has lost its natural curve and has become flatter.
- A neck that has extended forward into a more forward head posture. This will alter normal neck rotation and side-bending movement.
- Shoulder blades (scapulae) that don't rest correctly on the rib cage, which can lead to altered shoulder joint (glenohumeral) position and function.
I haven't even addressed what could go wrong with the pelvis, femur, knee, tibia, ankle, and foot. The lower body doesn't just hang out all happy and content while the upper body potentially suffers.
Some people live quite normally with these compensation patterns. It's likely that there is a degree of natural compensation tolerance built into human existence.
The problem occurs when the body's natural asymmetries become too great, and the compensation patterns become too extreme, that detrimental effects start to appear, often in the form of joint and back pain.
How do we Reclaim Our ZOA?
Reclaiming our ZOA always starts with addressing a forwardly rotated left pelvis.
We do this through pelvic repositioning exercise such as this (this is one of many)
Once that has been done, we work on establishing the left ZOA by incorporating the left obliques into our lives. Then we have to tie everything together so that we can keep our ZOA intact while walking, running, jumping and whatever else we choose to do.
Our ZOA is first exhibited through regaining neutrality in our upper body. Neutrality means that our rib cage/spine is positioned in a way that allows freedom of movement in our arms and neck. It our rib cage was positioned in a non-neutral position, certain arm and neck movements would be limited. Our movement ability is displayed through Postural Restoration® testing. If PRI testing displays lack of movement (and it almost always does) we reposition the pelvis first.
Sometimes repositioning the pelvis also establishes a ZOA and the upper body tests clear up at the same time. This can happen because the exercises used to reposition the pelvis puts you into a position that facilitates the left internal obliques and inhibits (turns off) other muscles, at the same time.
If the tests don't clear up then you work on getting the rib cage and spine neutral through more specific upper body exercises.
The Test
While the tests I mentioned tell you if neutrality has been achieved, they don't tell you if you can maintain neutrality while moving. That is what the Hruska Abduction Lift Test is for. It tells you if you can maintain a ZOA during dynamic movement on top of a neuro-muscularly strong left hip. The important thing is that the strength exhibited through the Lift Test is done without compensation.
Upon first glance, for any athletic minded person, the test doesn't seem like it should be too difficult. But I've seen many a strong men and women quiver and shake in a futile attempt to score even a 1 on a scale of 1-5.
It's not because these people weren't strong. It's because the position of their pelvis wouldn't allow non-compensatory movements to occur. The only way they could possibly perform the test was to use compensatory movements. When they weren't allowed to compensate, they were stuck.
In the pictures I show two of my clients who used to suffer from knee and lower back pain. You'll notice they are able to lift their bottom knee off the ground while holding their ankle to the knee. This is step #2 of the test. What they can't do is lift their bottom hip off the bench.
Fortunately for them, just achieving a lift test score of 2, which indicates better pelvic alignment and the ability to adduct a left leg (and abduct a right leg without compensation) was enough to relieve them of their pain.
The big strong people I mentioned before, including collegiate strength and conditioning coaches that I was in a seminar with up in Boston two summers ago, couldn't even lift their bottom knee off the bench without the usual compensation patterns of rolling their body backwards or over-arching their lower back in futile attempts to adduct that left leg. The reason they couldn't even lift the left knee was because their left pelvis was stuck forward, and this pelvic position wouldn't allow the left leg to adduct.
My clients got past the first step because we had already repositioned their pelvis so that it allowed true left leg adduction (bringing the left leg up off the bench).
When you can get to the position that I exhibit, (my goal for all my clients) you know you have a strong pelvis and a left ZOA. A strong pelvis and a ZOA provide:
1. A stable foundation off of which our appendages can move efficiently and powerfully.
2. The proper alignment for our spine, SI joints, hip joints, and shoulder joints. Misaligned joints, and the movement dysfunctions that result, are a major source of pain that doesn't seem to have any physical causes. In other words, MRI's and X-Rays don't show any obvious or abnormal physical damage to the joints, yet pain exists.
3. Proper breathing patterns. Without a ZOA, your diaphragm won't be positioned correctly to be the primary muscle of respiration. Other muscles of the lower back and neck will start to help out too much which can cause all sorts of problems, including lower back and neck tightness and pain.
Achieving a strong pelvis and ZOA doesn't take care of every physical pain, but from my experience it does take care of a lot. Most people I've helped have suffered from SI joint pain, knee pain, and shoulder pain.
These three joints are directly influenced by the position of the pelvis, spine, and rib cage, so it's no wonder that getting these structures into their natural positions helps clear up pain in those joints.
Chronic pain effects an estimated 100 million Americans, and I know this information could help them as it has helped me and my clients. Please consider clicking on the Facebook or Linkedin icons on the left to help spread the word.


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Proud members of the
The Amputee Connection of Redlands' mission is to serve and encourage people with limb loss to enhance their physical and emotional health through peer counseling, educational and recreational programs, and community outreach.
ACR serves individuals and families who live with limb loss and those
who may be having surgery in the near future.
The Amputee Connection of Redlands support group meets every
3rd Sunday of the month at 2:00 pm
at the Redlands Community Hospital in the Weisser Education Pavilion. (Building behind hospital) Follow the green signs in the parking lot.
Family, friends, and caregivers are welcome!
Redlands Community Hospital
Weisser Education Building
350 Terracina Blvd,
Redlands, California 92373
Social Media
In 2015, ACR launched a program of outreach in an effort to reach those with amputations who cannot attend monthly meetings. Through Skype we are able to bring professionals and others with amputations into their homes. This is an interactive format that allows for the Skype user to interact with the attendees and speakers.
Amputee Coalition Annual Conference
ACR provides opportunities for interested adults with amputations to attend the annual Amputee Coalition conference. This highly educational conference provides state of the art equipment and information relevant to the lives of people living with amputations.
We are also very active in sporting events, fund raising, and amputee networking within Southern California and on a Nationwide basis. We also are helping to get other support groups started such as the new group in the Coachella Valley and a Parents of Children with Limb Loss support group in Loma Linda. Please join us and help make a positive impact other new amputees lives. Speakers are available for presentations to your groups or organizations. Contact Luis at 213-700-0970 or leave a message for ACR at 909-423-0562.
Sports and Recreation - Engaging children and adults who live with an amputation is the heart of recovery. ACR participates annually in sporting events such as the DisAbility Sports Festival and the Angel City Games.
Community Service Events - ACR can be found supporting our local Grand Terrace Lions 5K & 10K Fun Run Walk for Freedom, Inland Empire Disability Collabrative Expo, Highgrove Day, and Grand Terrace Day each year. These events not only provide an opportunity for ACR members to connect to their community, but supports our efforts to give back.
Camp No Limits - ACR sponsors amputee children and their families for a weekend at Camp No Limits in Big Bear. Dedicated to children with limb loss and limb deficiency, Camp No Limits provides a unique and empowering experience.
The value of peers in recovery for a person with an amputation is invaluable from the day of amputation to their return home. ACR coordinates efforts to certify peer vistors. For more information please select the Peer Visits tab.
The vision of the Amputee Connection is to empower caregivers, families and friends to optimize the care and well being of people with limb loss in Southern California.
Donate now with Paypal
Monthly Meetings of ACR are designed to connect people with amputations and limb deficiency and share vital information relevant to their surgery, recovery and community resources.
2018 ACR Officers
Help support ACR's efforts by donating today. Your contribution is greatly appreciated.
For more information you may call our
Certified Peer Visitors
Luis 213-700-0970 (Fontana, CA) Se Habla Espanol**
Brenda 951-858-6274 (Corona, CA)**
Geoff 951-500-1360 (Redlands/Mentone, CA)**
Clyde 760-674-2473 (Coachella Valley, CA Se Habla Espanol**
Brian 951-675-7905 (Riverside, CA)**
Bill G. 951-259-7863 (Loma Linda, CA)**
Roberto 951-522-2449 (Riverside, CA) Se Habla Espanol
**Available on Skype
You may also leave a message at 909-423-0562 and we will have a Certified Peer Visitor contact you.
Copyright 2008-2020
The Amputee Connection of Redlands. All Rights Reserved.


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A GameCentral reader recommends his own playlist of video game-related podcasts, but this time only from independently produced shows and grass roots fans.
I wrote a reader's feature back in February about the podcasts I had been regularly listening to. I started listening to podcasts in September last year and mostly listened to the major sites' offerings – IGN, Giant Bomb, MSN, etc.
However, whilst the major sites still produce enjoyable podcasts, I have since become solely interested in the thriving independent* podcast scene. These podcasts are created and hosted by people passionate about gaming who, despite having full-time jobs and lives to live, put in a tremendous amount of effort and skill into recording and then editing weekly or fortnightly shows. It is a fantastic commitment and the podcasts are always produced to a professional standard.The best element about independent podcasts is that I can empathise with the contributors – whilst IGN, Giant Bomb, etc. are always discussing the very latest or even yet-to-be released games, the independent podcasts will cover new titles but also older games they have only found the time or money to play recently. This compares to my own life, with money and time at a premium I might take three to twelve months before playing a title like Zelda: Skyward Sword, Rayman Origins, or Uncharted 3.All of the contributors are likeable, articulate and immersed in gaming culture. They engage their listenership via Twitter and email, promote other podcasts via Twitter, and many appear on other podcasts as special guests. Not only do these podcasters spend time recording and editing regular podcasts, most maintain websites with videos, reviews and written articles covering a wide range of topics.So I decided to write this feature partly as a thank you to those people who invest their time creating excellent free content but also to highlight some of their fantastic work to GameCentral readers.I have included a link to one episode for each recommendation. I suggest GameCentral readers give each podcast a listen as I'm sure at least one of the below will suit their tastes.Note: Most of these podcasts feature explicit language and are not for under-18s. Chet and Jon's Reassuringly Finite Gaming Playlist
Two freelance gaming journalists (Chet Roivas and Jon Denton) discuss their top ten games of the week in order of time played – ten being the least and one being the most played. The other aim is to keep it within a forty minute time limit but they fail this aspect every week!This unique format means the hosts try a lot of games every week – leading to plenty of varied discussion from iOS freebies to Xbox Live Indie games to demos and the latest major console releases. The hosts have been friends for years which helps the flow of the podcast as they bounce off each other's gaming likes and dislikes. This is an excellent portal for gamers looking for their next purchase and the discourse helps promote some lesser known titles, which can only be a good thing in the crowded video game market. It can also lead to many a terrible Xbox Live Indie title being played, discussed and verbally destroyed. Also, the podcast has a fantastically memorable name! Joypod – presented by Spong.com
This podcast took time to grow on me and just missed out on being included in my original feature. It features four main hosts ( David Turner , Michael Fox, Sean Bell and James Farley) and covers what they've been playing, listener's questions and general chat. This podcast is very funny with self-deprecating hosts and some funny insights into their regular lives.I enjoy this podcast so much I have listened through their back catalogue of previous episodes. They even got a radio slot for a couple of years and do special episodes with live calls from listeners.They also have interviews with independent game designers such as New Star Soccer creator Simon Read. These interviews helped me to understand the years of effort, self-motivation and talent required in creating seemingly 'overnight successes' such as New Star Soccer.I have included a link to a special 'best of' podcast looking back over the five years of Joypod that provides a perfect sample of the humour evident on the regular podcast. This includes a survey (54 minutes into the podcast) of each of the three hosts' partners with questions relating to their gaming habits and the effect it has on their relationship. My own non-gamer girlfriend listened to, loved and empathised with this segment.Highlights of the survey include loving Bayonetta a little too much, getting a touch aggressive on FIFA and date nights spent researching prices of new game releases. It is the funniest podcast segment you will ever hear! Midnight Resistance
This is an irreverent podcast hosted by Sean Bell (also of Joypod) and Andi Hamilton. Although it covers regular aspects of video game podcasts – what we have been playing, listener's questions, etc. – the content of these segments is far from the norm. A recent example was an episode where the hosts discussed their 20 hour+ co-op playthrough of Phantasy Star Online 2, a game currently only available in Japan. I have never played the original Phantasy Star Online and have no intention of playing Phantasy Star Online 2 but listening to two English players describe how they 'can kinda work out the Japanese language side quests' had me laughing for ages.The listenership also provides ludicrous questions including: With Dishonoured due for release soon, which animal or object would you transform into to kill your fellow hosts? A man has to cross a river with one fan boy of Sony, Nintendo and Microsoft. However, he can only take two at a time with him. How does he cross?They usually have a special guest on every episode including Robert Florence (of Consolevania fame) Sean Bamberger (a PR man for SEGA) and many others which adds variety to each episode. Unlimited Hyperbole
I only recently discovered this podcast through following the Twitter accounts of the Joypod hosts and it has quickly become a personal favourite.The host, Joe Martin, a freelance games journalist, co-produces the podcast with Harriet Jones. Each podcast has a short running time, with fifteen minutes being the longest in the two series of five episodes each so far. This podcast is brilliantly focussed – It is edited so that the host and special guest are talking to the listener as opposed to the listener listening in on a two-person conversation. The producers use interview material that must be at least forty minutes long and condense them into sharp, thought provoking and entertaining episodes.Each series has an overarching topic of gaming discussion – series one focussed on 'My favourite game' and series two on 'Fear itself'. Although these topics may seem limiting, the discussions on each episode differ vastly and are always intriguing.As an example, the podcast link above is a Fear Itself episode where freelance gaming journalist Richard Cobbett discusses how his arachnophobia affects his gaming and writing career. The interviewee discusses his feelings of anxiousness and fear when facing spiders and provides examples of the many popular titles with spiders in them – Skyrim, Resident Evil, and of course Limbo.The guest on each episode includes video game story writers, video game journalists, developers and college lecturers.It really is a brilliant niche in video game podcasting that I cannot do justice in a few paragraphs so I implore you to give it a listen. Cane and Rinse
This was in my original feature and very much deserves its place on this list. Each week the podcast will cover a different game and discuss its gameplay, sound, story and the overall impact of the game series.The hosts Leon Cox and Tony Atkins are joined by regular contributors including Darren Gargette, James Carter, Joshua Garrity , Darren Forman , Karl Moon, and Sean O' Brien and will discuss their overall thoughts, likes and dislikes of the title. They also include listener email and Twitter feedback (including novel three word game reviews) which adds to the sense of community.They continue to release a new episode every week and cover a wide variety of titles – from Ghost Trick: Phantom Detective to Battlefield 3 to Kirby's Epic Yarn. I find the podcasts interesting to listen to even if I haven't played the particular game being discussed and on one more than one occasion it has inspired me to play the discussed title.Recently, the Cane and Rinse team have produced one show per month on the Metal Gear series – one podcast for each of : The original Metal Gear 1 and 2, Metal Gear Solid, Metal Gear Solid 2, Metal Gear Solid 3 , Metal Gear Solid 4 and Metal Gear Solid: Peace Walker. These were mammoth three hour plus episodes and for a confused gamer such as me that played and loved Metal Gear Solid 1 through 4; these were fantastic for filling in a lot of the story narrative in the series! Digital Gonzo
This one is a slight cheat as the Digital Gonzo podcast also covers films, television, comics and animated series. However, they have numerous gaming episodes including specials on Batman: Arkham Asylum and City, the demise of GAME and the brilliant two part Zelda episodes (the first discussing contributor's favourite aspects of the Zelda series and the second covers Skyward Sword in great detail.)This is hosted and produced by Alex Shaw and includes contributors Sharon Shaw, Joshua Garrity and special guests. The best thing about this podcast is the editing – the episodes flow superbly with sections of different interviews combining into one seamless podcast interspersed with clips of gameplay and soundtrack.This podcast came to my attention when they recently produced an astonishing eleven podcast special on Batman – covering all sorts of iterations from Adam West's Batman to The Animated Series, the games, the Nolan movies and even created a wonderful audio play called Batman Breakdown .
So there are my recommendations – I would love to know what GameCentral readers make of them in future Inboxes and I would welcome any further recommendations of quality independent gaming podcasts.By reader Angry_Cadaver (PSN ID/Twitter)*To define 'independent' podcasts – these are podcasts that, to the best of my knowledge, are created by people investing their own time and money without being paid to do so.The reader's feature does not necessary represent the views of GameCentral or Metro. You can submit your own 500 to 600-word reader feature at any time, which if used will be published in the next appropriate weekend slot. As always, email firstname.lastname@example.com .


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From the moment I asked my 4 year old what she thought of name choices and wound up naming my son, my daughter and my baby boy, have had a special bond.
I can't wait to see what their relationship is like as they grow up together.
Nobody makes Mr. Sunshine smile and laugh the way his big sister can. The sound of his laugh is precious.
Ariel took this picture herself because "Mr. Sunshine is sooooo cute!" Gotta say I agree.


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Buy Tickets
When you visit Perth Zoo, you're helping save animals in the wild.
You can buy general entry tickets and become a member online by clicking on the links below. If you are interested in a Close Encounter experience download the booking form to email to our close encounters team.


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More About JEFISLER
Visit My SparkPage Send Me SparkMail
Recipes I've Shared:
yummy low fat low carb low everything soup!
gluten free chocolate chip cookies
bake 350 for 10 mins or untill done
Strawberries, fresh, 6 cup, halves (remove)
Granulated Sugar, .25 cup (remove)
*Lemon Juice, .25 cup (remove)
stew in a sauce pot till thick (about 2 hours)
yummy low cal low fat quiche!! with optional crust nutrition is for with out optional crust. high in protein,low low in sugar, low in calorie, low carb
each pancake is 1/4 cup mixture
This is a great way to make a wrap without the bread, its crunchier too. low sugar
This is a healthy low sugar optional way to make a yummy dessert! only 5 ingredients! and takes only a few mins to make. Can also substitute different puddings and different fruits for different flavors.
Whole chicken with a new a tasty vibe
no bake LOW sugar, (not sugar free but low sugar) banana cream pie. made this up tonight. was very good!


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If the Hook up was not at your video shoot…
It didnt happen!
(Big statement I know lol)
So when the Uber-cool KIDBASS invited us to their video shoot for the club smash
Goodgirls ♥ Rudeboys..
We HAD to be there!
Directed by the superfly young director MO
This is set to be a visual treat.
Recently signed to Relentless Records,
Kidbass Featuring Sincere, are widely tipped as the most exciting new urban sound to emerge from the UK since Dizzee Rascal.
Their first single, 'Goodgirls Love Rudeboys' which samples the Moloko anthem 'The Time Is Now' , will be released 16th February 2009 with their debut album to follow in May 2009.
Kidbass Featuring Sincere, led by 24 year old North London rapper Sincere, is made-up of a collective of young producers; Justice Foolsworth, Godson and Short Circuit, whose musical backgrounds range from House to Hip Hop.
'Goodgirls Love Rudeboys' looks set to be the catchphrase for the New Year, and Kidbass Featuring Sincere the freshest sound to emerge in 2009.
Catch KIDBASS on myspace Click HERE
And stay glued to their website WWW.GOODGIRLSLOVERUDEBOYS.COM
for updates, competitions and a chance to meet ur own Goodgirl or Rudeboy.
Flicks by- FOTONAY
Words by-


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Lighting up the powerful global smoking lobby
Global public health efforts to reduce smoking are at odds with the interests of the tobacco industry. According to a case study published in the online open access journal Globalization and Health, competing tobacco companies co-operate via a global network of national and regional manufacturing associations to undermine public health measures to counter smoking.
Patricia McDaniel, Gina Intinarelli and Ruth Malone from the University of California, San Francisco dug deep into documentary data from tobacco industry documents archives. Their case study, which maps globally tobacco industry-linked groups known as "issues management organizations," draws upon previously secret tobacco industry documents and details some of the strategies these bodies used.
The International Committee on Smoking Issues (ICOSI) was formed in 1977 by seven tobacco company chief executives to create common anti-tobacco control strategies and build a global network of regional and national manufacturing associations. Later renamed INFOTAB, multinational companies built the organization rapidly: by 1984, it had 69 members operating in 57 countries.
According to the authors, INFOTAB material, including position papers and "action kits" helped members challenge local tobacco control measures and maintain tobacco-friendly environments. In 1992 INFOTAB was replaced by two smaller organizations: The Tobacco Documentation Centre, which continues to operate, distributes smoking-related information and industry argumentation to members, some produced by cross-company committees. Agro-Tobacco Services, and now Hallmark Marketing Services, assists the INFOTAB-backed and industry supported International Tobacco Growers Association in promoting tobacco's economic importance in developing nations.
"Policymakers should be aware that although these associations claim to represent only national or regional interests, they are allied to and coordinated with a confederation of trans-national tobacco companies seeking to protect profits by undermining public health," says Ruth Malone. "Cigarette manufacturers and their attorneys played the biggest role. Under their explicit direction, INFOTAB set policies and crafted strategies that ensured that the global tobacco community spoke and acted as one."
Tobacco is the second major cause of death worldwide, with 84% of smokers living in developing and transitional economy countries. Litigation against the tobacco industry led to the public release of over 47 million pages of internal industry documents housed in paper depositories and online electronic archives.
Source: BioMed Central
Explore further


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New Software from Adobe Targets HTML5: Edge
New features will be added to Edge, which in this public preview is focused on animation. The product manager of Adobe's Web Pro group, Devin Fernandez, discussed the future of Edge, stating that "[For] the first public preview release, we focused on animation. Over the public preview period, we'll be adding additional functionality. We'll be incorporating feedback from the community, taking those requests into account."
One key feature that will be eventually included is support for the HTML5 Canvas element, which is used as a 2D drawing surface for graphics which is often combined with SVG graphics. Edge is integrated with Dreamweaver to allow developers to weave their Edge creations into their web development projects.
Read the original article here.
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It's Official: Hard Rock Sioux City Casino and Hotel
Nicole Winters, Shift Editor
April 23, 2013
COUNCIL BLUFFS| Thursday morning (April 18th) the Iowa Racing and Gaming Commission met to make their decision about which casino will get the gaming license for Sioux City. Hard Rock Casino won the majority of the votes 3 to 2. The commissioners chose the $118-million land based casino proposal....
Hundreds Show Support For Sioux City Casinos
Nicole Winters, Shift Editor
March 27, 2013
SIOUX CITY| Over 300 people showed up Tuesday afternoon to make one last effort to show support at a public hearing in front of the Iowa Racing and Gaming Commission. This was the last open forum that the IRGC would take into consideration before voting on which casino will get the license. Each casino...


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Down South
Black Man Killed for 'Socializing with a White Woman,' Two Men Now Face Charges
After he was found dead on the outskirts of Griffin, Georgia, in 1983, the trauma a young Black man's family experienced hindered them from putting a headstone on his grave.
Because they did not know who took Timothy Wayne Coggins' life or if the killer would attempt to vandalize a clearly-marked burial site, they held a rushed, frightened funeral and left it plain, his niece Heather Coggins said.
Now, three decades later, after charges have been brought against the two White men responsible for his slaying, Timothy Coggins' name is finally etched into his grave site.
On Saturday the Coggins family presented the new headstone at their church in Zebulon, Georgia, about an hour drive south of Atlanta.
"This has been a very dark cloud on our family. But today we can see the sun will shine again," said Tyrone Coggins, one of the victim's brothers, during a spirited, 90-minute memorial service at Fuller's Chapel United Methodist Church.
The body of Timothy Coggins was discovered by hunters in a field a short distance from a highway in the Sunny Side community, which sits a few miles north of Griffin.
For decades his death remained a mystery. That is, until authorities made the announcement they apprehended the culprits Frankie Gebhardt, 59, and Bill Moore Sr., 58, last October. Arrest warrants tell the gruesome story of how the men stabbed and sliced Coggins to death and left him "seriously disfigured." According to one prosecutor, Coggins had also been dragged through the woods while tied to the back of a pickup truck. The motivation behind the heinous killing, according to Griffin Judicial Circuit District Attorney Ben Coker, was that Coggins, then 23, had "socialized with a White female."
The Coggins family has long believed his death was somehow connected to racism, said Heather. She went on to say they were too scared to mark her uncle's burial site at the time he was murdered, and as time continued to pass it was just left unmarked. But after the recent arrests were made in the case, she said family members pooled their money together to buy a headstone.
The tiny church in rural Georgia was packed with members of the huge, extended family, several of them wore t-shirts decorated with Timothy Coggins' picture and the words "At Last … Resting in Peace. A number of them also had on purple ribbons — the favorite color of their deceased relative.
A lot of the relatives who knew Coggins have passed away — and the multitude of cousins, nephews and nieces who filled the church were, for the most part, too young to have known Coggins, though they all have heard stories about his death since their early years, said Coggins' 35-year-old cousin Jennifer Stevenson.
"As his legacy, we feel as though we were robbed," she said. They never had the chance to meet the man who was known for his delightful smile and slick dance moves. And Coggins himself never got to marry, settle down, have a career and get to know the generation that succeeded him.
"Our family is amazing, and we are confident he would have been proud of us," Stevenson said during the service.
Many speakers told how Timothy Coggins was known for always walking his younger relatives home after dark.
"He always wanted to make sure everyone got home safely," said Tyrone Coggins. "This is confirmation to the family that 34 years later, Tim made it home."


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If a case can be made that they have something new or progressive to say, that can of course be made by way of reply on the thread.
C. Flower Admin.
We cannot withdraw our cards from the game. Were we as silent and mute as stones, our very passivity would be an act.
Jean-Paul Sartre
Look, all of these people from the Southern Unionist crew to the current extremist DUP leadership and the fleggers make Ian Paisley Junior look reasonable and really like the man we want to do business with.
Think about that. The son of the most extreme Unionist in history is now a moderate compared to these 'dinosaurs' spread around the Dublin elite in great number as well as the more extreme faction who have taken over the DUP since Robinson's demise.
Someone needs to go there, ask them the questions, challenge 'em, record it and put it on Youtube.
Ask them why they never have a word to say about British state forces collusion with Loyalist terrorist atrocities.
Ask them what they have to say about the allegations in this 1991 Channel 4 documentary:
and indeed earlier on, in the 1970s, the psychopathic mass murdering terrorists known as the Shankill Butchers.
Last edited by pluralist; 30-07-2017 at 03:51 AM.
"If you go far enough to either extreme of the political spectrum, Communist or fascist, you'll find hard-eyed men with guns who believe that anybody who doesn't think as they do should be incarcerated or exterminated. " - Jim Garrison, Former DA, New Orleans.
Kevin Myers, one of the speakers at the Festival, is trending on Twitter today, for a particularly venomous attack on women and Jews.
That comment by Kevin Myers doesn't get any better https://t.co/7QTKg6IKWo pic.twitter.com/VzpvUvIiRA— Felicity Morse (@FelicityMorse) July 30, 2017
Charming indeed. Many years ago he likened me in An Irishman's Diary in the Irish Times to an Israeli paratrooper, neatly bringing two of his obsessions together - feminism and Jews.
My crime was to present research on gender in education to a Joint Oireachtas Committee.
An Alf Garnett in cerebral clothing.
Harris on the other hand is a more driven type, a cynical propagandist. He's got a job to do and a lot of old scores to settle and will use any trick in the book to attack his targets.
"factualism is fancy foreplay which never penetrates the truth. Factualism is media masturbation" Eoghan Harris
A historian would need to have some kind of respect for the factual truth.
Last edited by Shaadi; 30-07-2017 at 01:21 PM.
Article deleted and apology issued.
He is getting savaged by the Brits over this and his previous comments on the holocaust.
Not a good day for Mr Myers at the History Fest:
"The Sunday Times press office has confirmed that columnist Kevin Myers will not write again for the Sunday Times Ireland following an article he wrote that has been criticised as anti-Semitic.
The Sunday Times apologised and said it abhors anti-Semitism after Mr Myers provoked controversy with comments on high-profile women working at the BBC."
There was no holocaust, (or Holocaust, as my computer software insists) and six million Jews were not murdered by the Third Reich
How was I not aware of this? How was he ever taken on by the ST in the first place?


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This article needs additional citations for verification. (October 2010) (Learn how and when to remove this template message)
|Dorothy Allison
|United States
|Coming-of-age novel
Publication date
|March, 1992
|Media type
|Print (hardcover & paperback)
|309 pp
|978-0-525-93425-7 (1st ed. hardcover)
Bastard Out of Carolina was the debut novel of Dorothy Allison. The book, which is semi-autobiographical in nature, is set in Allison's hometown of Greenville, South Carolina in the 1950s. Narrated by Ruth Anne "Bone" Boatwright, the primary conflict occurs between Bone and her mother's husband, Glen Waddell.
The novel examines the expectations of gender and mother–child relationships, and explores the roles of these characters in the future. Conditions of class, race, sexuality and gender play out in Bone's life and her relationships with others.
The book was adapted into a film in 1996.
The book opens with Bone relating the details of her birth. Bone's 15-year-old mother Anney gives birth to her after being seriously injured in a car accident. Anney, who is comatose during the delivery, is unable to lie about being married. Her mother and older sister Ruth attempt to give a false name and are caught in their deception. This results in Bone being declared a bastard (an illegitimate child; born out of wedlock). Anney, who "hated to be called trash", then spends the next two years unsuccessfully petitioning to get a new birth certificate issued without the word "illegitimate" stamped on it. This opens her up to the ridicule of the customers in the diner in which she works.
At age 17, Anney marries Lyle Parsons and gives birth to another daughter, Reese, in short order. Lyle is killed in a car accident, leaving Anney "all bitter grief and hunger". After remaining single for a few years she begins to date Glen Waddell, the son of a socially prominent dairy owner. Two years later, as a result of her becoming pregnant, they get married.
Anney gives birth to a stillborn boy and becomes unable to have more children. During labor, Glen masturbates while touching Bone in the car. The family's fortunes plummet, with Glen losing job after job due to his anger management problems. It is then that Glen begins sexually molesting her. The abuse culminates in beatings and whippings that leave Bone nursing bruises and broken bones.
When Anney discovers the abuse, she leaves Glen, who promptly promises never to do it again. Anney takes him back and the abuse resumes. Anney leaves Glen again after her tough, hard-drinking brothers severely beat Glen upon discovering that he has beaten Bone once again. Bone then announces to her mother that she will never live in the same house with Glen again. Bone tells her mother that she loves her and will forgive her if she decides to go back to Glen, reiterating that she will not return to the house with Glen. Her mother then vows not to go back to Glen unless Bone comes with her.
When Glen discovers this, he attacks Bone at her Aunt Alma's house, breaking her arm and raping her on the kitchen floor. Anney walks in on him and fights him off. Glen follows the two out to the car, begging Anney to kill him rather than abandon him. To Bone's disgust and amazement, Anney ends up crying and throwing her arms around Glen.
Bone's aunt Raylene visits her at the hospital and takes custody of Bone, as Anney has disappeared. While Bone is recuperating at her aunt's house, Anney shows up with a new birth certificate for Bone, this time without the word "illegitimate" stamped on the bottom. She asks Bone's forgiveness and leaves without telling her where she is going.
- In the July 5, 1992, edition of The New York Times Book Review, George Garrett said the book "in no way seems to be a patchwork of short stories linked together. Everything, each part, belongs only to the novel" and "close to flawless". He compared it to J.D. Salinger's novel Catcher in the Rye and Harper Lee's novel To Kill a Mockingbird, writing, "Special qualities of her style include a perfect ear for speech and its natural rhythms; an unassertive, cumulative lyricism; an intensely imagined and presented sensory world, with all five senses working together; and, above all, again and again a language for the direct articulation of deep and complex feelings."[1]
- K. K. Roeder in the April 1991 publication of San Francisco Review of Books states that Allison: "relates the difficulty of Bone's struggles with intensity, humor, and hard-wrought rejection of self-pity, rendering Bastard a rare achievement among works of fiction dealing with abused children."[1]


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A new twist on a family favourite dessert. I used a mix of green and red apples for a tangy but sweet apple crisp.
|Dempster�s� Apple Pie flavoured Bagels
|and chopped
|1/2 cup
|White sugar
|2 tbsp
|Orange juice
|2 tsp
|1/4 cup Flour
|3/4 cup
|Brown sugar
|1/2 cup
|1/2 tsp
|1/2 tsp
|Ground cloves
|3/4 cup
|Caramel sauce (usually in produce section of grocery store
|Aluminium foil
Preheat oven to 350 degrees.
In a medium bowl, mix apples, white sugar, orange juice and 1 tsp cinnamon.
In another bowl, mix flour, 1 tsp cinnamon, brown sugar, butter, salt and cloves. Mash the mixture until it is crumbly.
To make double decker bagels, take bagel tops and slice horizontally to make two pieces.
Line baking pan with foil. Place bagel bottoms in the pan. Spread flour/brown sugar mixture on bun bottoms. Add a layer of the apple/sugar mixture.
Place the bagel center pieces on top the apple mixture to begin the next layer. Spread the flour/brown sugar mixture on top of the bun centers and add a few spoonfuls of the apples/sugar mixture.
Put the bun tops on top of the buns, and sprinkle a few tablespoons of the flour/brown sugar mixture on top of the buns. (Drizzle apple caramel sauce over the top of buns if desired).
Place another piece of aluminium foil over the bagels, pinch around edges but leave some spots open to vent steam.
Bake for 25 to 30 minutes. After 30 minutes, open foil to expose bagel tops. Continue cooking for 5 to 10 minutes, until the tops are golden brown.
Remove apple crisp bagels from the oven and serve with vanilla ice cream or whipped cream.
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A Full Groom Consists Of:
A Hydrosurge Bath
High Powered Blowout and Dry
Comb Out
Ears Cleaned
Nails Clipped
Sanitary Shave
Style or cut
All Prices are for regular 4-6 week or 6-8 week appointments
in some instances in the larger breeds it will be 8-12 weeks
Extra fees will apply for appointments over these time frames because it is WAY more work
It is always good to start a puppy in the grooming process
at a young age, that way they get used to the whole experience
and learn to enjoy it. It also helps with socialization and patience
All Dogs MUST be up to date on their rabies
and a copy must be supplied at check in
That is for the safety of both the groomer and the owner in the event of a bite.
All prices are estimates and subject to change at any moment
depending on the dogs coat, temperament, matting, or cooperation
We do everything possible on our end to make the experience enjoyable
however sometimes it is just necessary to muzzle....we have worked with all temperaments
and pride ourselves in overcoming the willful ones in most cases :)
For Appointments and Prices
Please call: 814-752-6444 or Call / Text : 601-209-9557


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3 Frequently Asked Questions When Considering an Office Move
August 8, 2016
Whatever your reasons for considering an office move, the process can be daunting and filled with uncertainty.
How far in advance should we be thinking about an office move?
Who should be involved in the process?
How do we determine what we need?
Amid all these unknowns, one thing is certain: you need to plan for the future even if you can't predict it. Here are answers to three frequently asked questions when considering a move.
How far in advance should we be thinking about an office move?
Earlier than you probably think. Even if you're not moving and just renegotiating your lease, it is critical you give yourself enough time to make decisions and thoroughly negotiate the terms you need. Timelines vary per project, but begin planning no less than six to nine months before your lease expires. Start with the big picture. Your move is about more than picking a new building. Real estate decisions impact every facet of your business: productivity, revenue, well-being, sustainability and future success. Allow enough time to fully assess your company's needs. Only once you figure out who you are as a business can you design a workplace to support it.
Which internal stakeholders should be included in this process?
Build consensus among the executive team and senior leadership to ensure an efficient process. Making sure you have the right team on board from the beginning is critical. Not building internal consensus throughout the process is a common pitfall in making real estate decisions. Many companies get ready to execute on a new lease only to have the deal go sour because they lack board approval or executive consent. Avoid a late-stage veto by keeping the entire team informed each step of the way. If you approach your move on a unified front, employees will be confident in the final decision as well.
With regards to broader employee opinion, a survey in the planning phase can be a good way to inform leadership of employee preferences. Although talent considerations are one of the most important criteria in developing a real estate strategy, decisions should ultimately be made by a core real estate team. This team can form a strategy that takes employee opinions into account while also ensuring core business objectives are met.
What if I can't determine my headcount but we need to make a decision?
Small companies or startups may not have this issue, at least at first, but with growth it can become incredibly difficult to determine your company's headcount. The size of your company will determine both the time the move will take and the type of lease terms you're likely to get. A headcount growth and space analysis should be completed in the planning phase of the process. Consider how many executives you have, as well as other staff levels, such as sales professionals or engineers. Make projections for future headcount by each staff level. Growth metrics can help you make an educated guess. While growth metrics can vary from industry to industry, looking at trends from similar companies can help establish a baseline for your business.
Navigating real estate decisions can be challenging. For this reason, JLL has launched TechSpec, a one-stop site for companies, especially tech firms, in pursuit of the best workplace. TechSpec features content and resources ranging from tenant guides and case studies to leading industry research and expert input to help you find the design and space that's best for you. For answers to more frequently asked questions and common pitfalls to avoid, visit TechSpec today.


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Thursday, February 23, 2012
Then my rifle jammed.....
- Swamprat
9 comments:
- drjim said...
Good one!
- February 23, 2012 at 11:51 AM
Should have used an AK or an HK instead of the AR. Still be rockin' n rollin'.
- February 23, 2012 at 1:58 PM
- Hello Birdy said...
I was sitting at a stoplight yesterday, minding my own business, waiting for it to turn green.
A carload of bearded, young, loud Muslims, shouting anti-American slogans, with a half-burned American Flag taped on the trunk of their car and a "Remember 9-11" slogan spray painted on the side, stopped next to me.
The light changed, the Muslims praised Allah, shook their fists, hit the gas & darted off ahead of me.
Suddenly an 18-wheeler came speeding thru the intersection & ran directly over their car, crushing it completely, killing everyone in the car.
For several minutes I sat in my car thinking to myself, "Man... that could have been me!"
So today; bright and early, I went out and got a job as a truck driver.
- February 23, 2012 at 3:50 PM
- Ramon said...
Clean that '50' and you can avoid that problem....
(What is outstanding is that Barrett is only about 100 miles from where I am.)
- February 23, 2012 at 3:57 PM
Mr L
Agree ... cue the rimshot.
But, did you see the news today outta Pennsylvania ? Link sent ya. Humor is healthy displacement, so far ....
American judge says it's OK for a POS Mooselimb immigrant to assault an American citizen. Cool. Solgoode. Gotsta be Culturally Sensitive, Diversively Inclusive, Politically Correct and Supine in the face of these primitive goatfuckers and moon-worshippers.
Soon now. Very soon. HNIC has already stated he'd side with his kin "if an ill wind blows"
OhioDude aka the Infidel
- February 23, 2012 at 4:05 PM
- Brock Townsend said...
:) Good one.
- February 23, 2012 at 5:34 PM
- PISSED said...
I'm sitting here at 8:46 pm with a beer..waiting for you to post something from the west coast :)
- February 23, 2012 at 5:46 PM
Funny stuff - Birdy gets a prize, too.
- February 23, 2012 at 10:27 PM
- Goldenrod said...
Gernades don't very often jam and it's just as much FUN!
- February 24, 2012 at 2:49 PM


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For the first time since Game Six of the 1981 World Series, the Yankees will play a playoff game today without either Derek Jeter or Mariano Rivera on the active roster. Rivera's season came to an end due to a knee injury months ago, but Jeter fractured his left ankle just last night and will miss the remainder of the postseason. The Game One loss by itself was demoralizing, but adding the Captain's injury on top of that pushed yesterday into contention for the worst baseball day ever.
Alas, no one will feel sorry for the Yankees. They lost Game One not because Jeter got hurt, but because the offense again failed to capitalize on numerous opportunities. Jose Valverde's meltdown spared them the embarrassment of being shutout, though I think getting shut out would have been preferable to everything that happened after the Yankees tied the game. The pitching has been fantastic, the offense not so much. I've run out of words to describe them, so I'll just stick with "maladroit" today. Here are the starting lineups…
Detroit Tigers
CF Austin Jackson
LF Quintin Berry
3B Miguel Cabrera
1B Prince Fielder
DH Delmon Young
LF Andy Dirks
SS Jhonny Peralta
C Alex Avila
2B Omar Infante
RHP Anibal Sanchez (9-13, 3.86)
New York Yankees
LF Ichiro Suzuki
2B Robinson Cano
1B Mark Teixeira
DH Raul Ibanez
C Russell Martin
3B Alex Rodriguez
CF Curtis Granderson
RF Nick Swisher
SS Jayson Nix
RHP Hiroki Kuroda (16-11, 3.32)
It's beautiful and surprisingly warm in New York today, so it's a good day for baseball. First pitch is scheduled for 4pm ET and the game will be broadcast on TBS. Try to enjoy.
Ticket Update: If you want to catch any game in this series, either in New York or Detroit, make sure you check out RAB Tickets for some sweet last minute deals.


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Last Wednesday the VUWSA executive passed the 2006 budget. The budget passed shows that VUWSA will make a $103,000 deficit for 2006. In 2005 we made a deficit of roughly $100,000. In both 2006 and 2005 the Student Union complex contribution of $175,000 wasn't charged, and if it had been, our deficit would be closer to $300,000 for each of those years. In 2004, the only reason we made a surplus was because the $175,000 wasn't charged. Next year, given the really positive progress we have made on the Student Union complex negotiations, we expect to be paying the $175,000 once again.
This week Salient is doing a feature on the levy and related issues, so I'll try not to double up. But the basic facts are that VUWSA has a levy of $99 which was set back in 1998 for the 1999 financial year. Every year our costs go up with inflation, but the levy remains static. At the VUWSA AGM on September 6th we are likely to be discussing the possibility of raising the VUWSA levy. At this meeting students will have to decide whether they want to maintain current levels of services and increase the levy, or keep the current levy which will mean that VUWSA has to significantly reduce its level of operations.
Elsewhere in this magazine I've written a piece opposing increases to student fees. Some could argue there is a contradiction between arguing that the VUWSA levy will probably have to increase its levy and not wanting the university council to raise tuition fees. The fundamental difference here is that tertiary education is a public good and should be publicly funded (which has been VUWSA's position throughout the ages) and that increased costs to institutions like Victoria should be covered by the government. Fundamentally the proportion of costs that students pay in course fees is already too high now, so any increase exacerbates this problem.
By contrast I believe that the $99 VUWSA levy set in 1998 was correct at the time. However after 8 years of cost increases, the expansion of Victoria onto four campuses and with the general cost increases it is clear that there is a gap. Currently VUWSA's level of expenditure is too high for its annual income. VUWSA's main source of income is the levy. Our levy is one of the lower ones in the country; by comparison Massey Wellington charges $130 and Massey Palmerton North charges even more. At the University of Auckland the students' association largely relies on money from the university to provide services, and they do this due to being a voluntary association (the only university students' association in Aotearoa that is). Generally a lot of the services that VUWSA provide are of considerable importance, and if we didn't provide them the university would have to pick up the tab. In reality if VUWSA's levy stays the same or drops, it would result in the university increasing levies such as the student services levy or the Amenities to pick up things VUWSA could no longer fund (eg. SJS, Welfare services, advocacy services, clubs etc). At least with the VUWSA levy students get democratic control over how this is spent.
When I first started on the exec in 2003 our concern was that our surplus was too high and this meant we hadn't spent enough of the student money given to us. The previous year the exec had faced issues with over spending, and had made considerable cut backs, which many of us believed cut into what was VUWSA's core business (cutting club grants etc). From 2003 onwards we returned to previous levels of spending and started extending our services to satellite campuses (Pipitea mainly). I still believe this was the right decision, but clearly the revenue situation hasn't been addressed since then.
A number of our processes are also in need of review. Since 2003 the earliest we've managed to pass a budget was August of that financial year (this year included). There are various other processes that also need serious review. The VUWSA Trust has agreed to pay for Horwath Strategy (Wellington) Limited accountants to come in and review our financial and budgeting systems. They will go through and look for ways we can be more efficient and provide the services that we want in the most cost effective way. They will also be looking at our revenue and expenditure levels, and make suggestions as to what might be considered appropriate.
We will also be looking at ways to improve our accountability structures within VUWSA. Part of this is getting the budgets done on time. In our 2006 strategic plan we have set a target of getting the 2007 budget done by the end of this year. We will work with the incoming 2007 executive to see that this is done. This provides VUWSA with far greater accountability and financial control from day one of the next financial year.
The current budget issues we have are clearly fundamental, and have now existed for a number of years. As the VUWSA President I am committed to working through this issue and seeing that we have the best possible result for students, both in the short and long term. I look forward to getting VUWSA back to a position of financial health for the coming year.
Part 2 of the SRC series on the current crises in with Israel, Lebanon and Palestine. This week David Zwartz, the honorary Consulate in NZ for the Israeli government and Don Carson from the Wellington Palestine group will debate the current issues. 12noon, Wednesday in the Mt Street Bar and Cafe.
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This is a propaganda piece outlining the reasons for a levy (fee) increase and doesn't mention the unnesescary spending in the VUWSA budget like the $250 on having a photo taken, $3000 on taxi trips, $1021 on dinners, $1 600 on decorations, around $9 000 on having three new unesescary exec members or plenty of other cases of unessescary extravagence and spending. I think students should know what VUWSA spends its money on.
yeha thatll make a big difference to the budget eh o'kane….. around $13,000…. yeah right…..
Does anyone else think Nick Kelly looks kind of like a girl?
a slightly nerdy but could be hot girl :) wow
Nick, you are a dick, whoever you are.
It's a president's column. It's the President's opinion of where he wants to take his organisation. It's not even trying to NOT be propaganda.
"yeha thatll make a big difference to the budget eh o'kane….. around $13,000…. yeah right"- this $13 000 is just the begining. What will make a big difference is the half million spent in "salaries", the $50 000 in honoriaria and bonuses. While some of this spending is legitimate, given that we can find unesescary spending in these areas were likely to find it hidden under various headings.
I think its correct that this piece is largely my opinion on the current Financil and budget situation of the Students' Association. It would be concerning if the VUWSA President as the Financial leader of the association didn't have an opinion on the levy or the budget.
At the same time we are having a review to look at ways to make our $$ go further. However the issue is that when the income recieved from the levy and other sources is $300,000 less than our expenditure is likely to be in 2007 once we are paying the contribution to the Student Union Complex then its clearly time to look what the levy should be. Ultimately it is the students who will make the call at the VUWSA AGM on Septmeber the 6th. But I felt it was important to use my column this week to give my point of view having spent a considerable amount of time working on this issue.
But in the mean time the Taxi Chits are locked in the safe, there a no more dinners or even food at exec meetings…so fear not we are making savings.
I recon I look more like Jimmy Page from Led Zeppelin…
At the AGM, Nick?
Schedule 5, cl 1 of the VUWSA Constitution makes it clear that the annual subscription is set at an SGM:
"The Executive shall determine the budget, and recommend the level of annual subscription to a Special General Meeting."


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Used Dodge dealer Edmonton AB
A few of the most highly debated topics in the automotive industry include leasing vs financing, warranty vs no warranty and new vs used. At Great West Chrysler, we feature both new and used vehicles, but we're quite proud of our used vehicle inventory. Not only are they all very fairly priced, but they're reliable and sturdy, as we inspect each vehicle prior to the sale of it so you can be sure to get a safe vehicle.
If you're looking for a used Dodge dealer Edmonton AB with a great variety of vehicles for affordable prices, you've come to the right place. At Great West Chrysler, we even have our inventory of used Dodge vehicles on our website, making your research and search for a new-to-you vehicle that much easier.
Whether you're looking for a newer used Dodge vehicle that will last for years to come, or are looking for something more affordable rather than clad with features, we're sure to have a vehicle to fit your needs.
Being a used Dodge dealer Edmonton AB isn't a title we take lightly. We know and love Dodge vehicles so much because they are affordable, reliable and extremely easy to handle. They are great vehicles for just about any occasion, and there are a wide variety of models available within the Dodge lineup.
Over the years, Dodge has manufactured everything from sports cars to pickup trucks to minivans and everything in between. And the crazy part is that all of them have been successful among consumers! The only explanation we could come up with that is that Dodge vehicles are truly just great quality vehicles that are suited to fit any lifestyle.
A few of our most popular used Dodge vehicles include the Dodge Charger, the Dodge Challenger and the Dodge Grand Caravan.
For the most current selection of used Dodge vehicles, we encourage you to visit our lot in Edmonton AB, but you can also get an idea of our selection online. We hope to see you soon!


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|Proceedings of the International Congress of International Association of Societies of Design Research (IASDR). Shibaura Institute of Technology, Tokyo, Japan.
|Piotr Michura, Stan Ruecker, & the INKE Research Group
In this paper, we report on a tool we developed for use by our students as part of a senior-level undergraduate degree course in Information Design. Students were asked to re-design a web site for a local not-for-profit agency. The first part of the project asked them to conduct an environmental scan on the topic most closely related to the client: HIV / AIDS, using a new tool we developed, comprised of 6 semantic differential scales, then asked them to research and select web sites dealing with HIV / AIDS, and analyze the visual components for each site according to how they position along each scale. We modified the semantic differential scale (typically constructed from a set of opposite word pairs) by asking students to extract visual examples from a web site, then place each sample along the scale between the two contrasting word pairs. The end result was a collection of 84 visual analysis grids. This method allowed us to compare multiple visual analysis for the same web site, observe patterns for sites about HIV / AIDS, and discuss the contribution of specific design elements towards a particular type of look and feel. The samples were multi-modal: our analysis was contextual to the original objects of study.


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Walking for health
Walking for health
Walking is a fantastic way to get – and stay – healthy.
One of the reasons health experts give walking such rave reviews is because it's a 'lifestyle exercise'. That means you can usually make time for it without too much of a change to your daily routine. Walking to work, to the shops, or the final mile from the bus stop to your friend's house may take a little more time, but it's certainly not the big project that signing up for a gym (and making the time to get there) can be.
Because it's easy to fit into everyday life, people who walk tend to keep it up. And as you'll see below, regular exercise is exactly what you need to improve your health.
What are the health benefits of walking?
Here's a startling fact for you:
Burning 500-1000 calories per week (that's about 6-12 miles walking for an average weight person) reduces the risk of premature death by 20-30%.
Walking will help protect you against:
- Cardiovascular disease (coronary heart disease and stroke), as well as 'risk factors' such as high blood pressure and cholesterol
- Cancer (particularly bowel cancer, and breast cancer in post-menopausal women)
- Type 2 diabetes
- Obesity
It has also been shown to improve:
- Musculoskeletal health (for example osteoarthritis and lower back pain)
- Mental health, happiness and well-being
© iStock/Eduardo Jose Bernardino
How much walking should I be doing?
The UK's Department of Health guidelines are pretty straightforward: For general health, adults should do 30 minutes a day of moderate intensity physical activity, on five or more days of the week. Children and young people need to exercise for at least an hour each day.
The great news is that your 30 minutes of activity doesn't all have to be in one go, so you can build up that amount in short walks of 10 minutes or more. (Of course there are many different kinds of exercise that you might choose, but we're focusing on walking for obvious reasons!)
You'll receive even greater health benefits if you do more than your 30 minutes, but there's a 'law of diminishing returns' – that is: the amount of extra benefit you get for each extra 30 minutes will be slightly less than the 30 minutes before it.
The most important thing to remember is that most of the health benefits you receive from being regularly active are lost if you don't keep that level of activity up.
So steady, regular exercise throughout the year – and throughout your life – is much better for you than wearing out your trainers in January and crashing on the sofa for the rest of the year!
What does 'moderate intensity activity' mean?
Because everyone has a different level of fitness, it's not possible to say exactly how fast you need to walk to reach the level of 'moderate intensity'.
The important thing to focus on is not your speed, but how it feels. You need to be aiming for:
- An increase in your breathing rate
- An increase in your heart rate, to the level where you can feel your pulse
- An increase in your body temperature (possibly even working up a bit of a sweat on hot or humid days)
A great technique is to imagine you're late for a train that you've booked a ticket on, and need to rush to the station before it leaves without you. With that in mind, you'll find that your walking becomes much more energetic and purposeful!
Remember that you don't need to overdo it. The right pace is one that you should be able to keep up for many minutes, and you shouldn't be exhausted at the end of it.
So… now that you know what you need to do, why not dig out your comfy walking shoes, find an interesting walking route and start walking your way to a longer, happier and healthier life?


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Apply for the World Veterinary Day Award 2016
Deadline: 10th May, 2016
To celebrate the World Veterinary Day (WVD) that will take place globally on 30 April 2016, the World Veterinary Association (WVA) and the World Organisation for Animal Health (OIE) are organizing the World Veterinary Day Award 2016 to reward the most successful contribution by the veterinary profession on the selected theme for 2016: Continuing Education with a One Health focus. The competition is open to all WVA member associations, alone, or in cooperation with any other selected body. The winner association of the 2016 Award will be presented at the Opening Ceremony of the OIE 84th General Session to be held in Paris, France on 22nd May 2016.
Veterinarians play a crucial role in protecting global health. In all areas of the profession, they have opportunities and responsibilities to improve the health and welfare of animals, and therefore, to improve the health of humans.
In the current era of globalisation, the emergence or re-emergence of unexpected sanitary events is accelerating. It is estimated that five new emerging infectious human diseases appear each year, of which three are zoonotic. The recent Ebola epidemic as well as the too numerous human deaths caused each year by rabies, dreadfully remind us of the strong links existing between the health of people, animals and environment and consequently the need for multi-sectoral approaches illustrated through the 'One Health' concept.
All countries depend on the performance of their national Veterinary Services, in their public and private components, not only to successfully control these diseases, but also to tackle food safety issues and to effectively prevent and control any biological disasters. Therefore, veterinarians should be well trained to preserve animal health and welfare, as well as to tackle public health issues.
The organisers will select the winners according to the quality of their project and activities, their ability to raise awareness on the topic, through communications materials and media coverage in their country, as well as their capacity to demonstrate a concrete implementation of the 'One health' approach
For the first time this year, entrants have the possibility to present activities that took place before World Veterinary Day 2016, that are still on-going, or that are planned to take place in the future.
All fields in the application form (attached to this document) shall be properly filled out and emailed at firstname.lastname@example.com no later than 10 May 2016.
To apply for this award and for more information about the event, visit World Veterinary Day Award 2016


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In ALS Association-supported work published in the journal Neuron, researchers have announced the discovery of a new gene for ALS, which further implicates defects in the cellular transport system as a cause of the disease. A video abstract is available here.
The newly discovered gene, called TUBA4A, encodes the Tubulin Alpha 4A protein. This protein is part of the microtubule "cytoskeleton" of every cell, including motor neurons, the cells that die in ALS. Microtubules give structure to the cell and also transport many important molecules within the cell, including growth factors critical for neuron survival. Previous work has suggested that defects in microtubule transport of growth factors are a cause of neurodegeneration.
To discover the TUBA4A gene, the team looked for gene variations in more than 600 people with a familial form of ALS that was not due to known genes. They identified several variants in the TUBA4A gene in six ALS cases, and they showed in cell culture that these variants caused defects in microtubule structure and transport.
The new research was led by Vincenzo Silani, M.D., of the Istituto Auxologico Italiano in Milan, Italy; Christopher Shaw, M.D., of King's College London; and John Landers, Ph.D., of the University of Massachusetts Medical School, Worcester, Massachusetts. Additional funding for the study was provided by the Motor Neuron Disease Association of the United Kingdom. Dr. Landers is also co-principal investigator for the United States arm of Project MinE, an international effort to sequence the genomes of at least 15,000 people with ALS, supported by The ALS Association.
"This discovery strengthens the evidence that transport defects in neurons can lead to ALS," said Lucie Bruijn, Ph.D., M.B.A., Chief Scientist for The Association. "Strategies to overcome those defects may provide a route to development of therapy. This new gene also presents us with an opportunity to develop a new disease model, which may reveal further targets for drug development, to mitigate the effects of this mutation."