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Future Shock (Future Shock #1)
By: Elizabeth Briggs
Publisher: AW Teen
Publication Date: April 1st, 2016
Format: eARC
What do you do when the future is too late, and the present is counting down to an inevitable moment?
Elena Martinez has street smarts, the ability for perfect recall, and a deadline: if she doesn't find a job before she turns eighteen, she'll be homeless. But then she gets an unexpected offer from Aether Corporation, the powerful Los Angeles tech giant. Along with four other recruits—Adam, Chris, Trent, and Zoe—Elena is being sent on a secret mission to bring back data from the future. All they have to do is get Aether the information they need, and the five of them will be set for life. It's an offer Elena can't refuse.
But something goes wrong when the time travelers arrive in the future. And they are forced to break the only rule they were given—not to look into their own fates. Now they have twenty-four hours to get back to the present and find a way to stop a seemingly inevitable future—and a murder—from happening. But changing the timeline has deadly consequences too. Who can Elena trust as she fights to save her life?
The first book in an unforgettable series about rewriting your destiny in the city of dreams.
With perfect recall and a great set of street smarts, life should be going pretty well. However, when you are stuck in a shoddy foster care system and the time you have to get your life together before you are kicked out of said system is waning, you have some major problems. Under those conditions, signing up for secretive government testing, that has injury waivers written into the contract, doesn't sound like a bad idea.
Enter Elena Martinez, our fierce and spunky protagonist of Future Shock who will fight for the underdog but really just wants to be left alone. She is kept company by a diverse cast of characters who are well fleshed out and have a strong and believable role in the story, ones not easily interchanged or replaced. They each are fighting to change unwanted futures that have had drastic effects on their lives and those around them, which lies in stark contrast to why they were picked in the first place: they were seen as inconsequential. As the story unfolds, it was great to see the group meld together, begin to trust one another, and be called friends. Throughout, Elizabeth weaves a great narrative that has the reader convinced of certain outcomes before pulling the rug out from under you. The many twists of the story keep the tension high and the main mystery is the focus of the novel and the romance plays out in the background and is threaded into the main story in a very believable way.
Future Shock was a great, quick read that was instantly absorbing and entertaining. I can't wait for the sequel, but it also scares me a little, because I don't know where our protagonists are going to go from here.
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Disclaimer: The synopsis and cover picture were pulled from the book's Goodreads page. Neither belong to us.


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First I will start with the conclusion of this post, also added at the end of the post:
Gluconeogenesis is a mechanism that needs to be addressed specifically in advanced cancer patients that are seeing fast loss of body mass.
One major way to reduce Gluconeogenesis is via oral administration of Hydrazine. This is a tool with great potential. However, since it has also some potential side effects, I would only use it in emergency case, when wight loss is present and can not be inhibited in any other way .
When I find time, I will search for other Gluconeogenesis/PEPCK inhibitors that have less or no side effects.
This article addresses one of the aspects I think is of major relevance in cancer. That is gluconeogenesis.
I find this subject extremely important, specifically in case of advanced cancers, as it is connected with several important points I've observed during the past years:
- during the advanced stage, cancer patients see their weight declining fast
- this is concomitant with an increase of systemic inflammation
- this is concomitant with increase of blood glucose level
- this is concomitant with increased tumor activity
I was specifically triggered by the increase of blood glucose level for most of the cancer patients in advanced stage, as I did not understood exactly why at some point suddenly, the blood glucose jumps to a high level and remains there and may not be controlled by the diet. I think this is a very important event, which if we could understand and find ways too inhibit its occurrence, we could be able to strongly interfere with cancer progression.
Now, after spending some time diving deeper into the related scientific literature and connecting various pieces of information, things start to make sense.
Indeed, it is well known that inflammation is a state of the human body in which cancer can become more active and in turn produce more inflammation (Ref.1, Ref.2). It is the same point when markers are jumping up, as seen in the blood results of many cancer patients and it is correlated with a CRP increase and tumor marker increase. Here is a relevant Youtube video where Dr. Vikas P. Sukhatme at MIT in Cambridge, MA, explains the very important role of inflammation in cancer progression.
In relation to inflammation level in patients, white cell counts such as neutrophil, lymphocyte and platelet counts and acute phase proteins, such as C-reactive protein and albumin and their combinations, neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) respectively have been all reported repeatedly to have prognostic value (Ref.).
Among many negative aspects of inflammation, one aspect that it is specifically relevant in advanced cancers is related to the fact that inflammation triggers the activation of the hypothalamic-pituitary-adrenal (HPA) axis (Ref.). This is the same axis that is activated by stress and the result is that the adrenal gland will start producing cortisol and release it into the blood stream. In turn, cortisol (which is a glucocorticoid) activates a systemic response in the human body leading to a loss of skeletal muscle mass, which is also a hallmark of cachexia (Ref.). Skeletal muscle mass loss can also be triggered by other processes, including release of IL-6 following inflammation (Ref.). Elements resulted from the breakdown of muscle mass, are converted by the liver in glucose, facilitated by a mechanism called gluconeogenesis which is also activated by the cortisol. Gluconeogenesis, is the process through which the human body can start burn body mass during starvation, in order to obtain glucose – the much needed source of energy (Ref.). This is the same mechanism that makes us loose weight during periods of high stress.
So now we have the link between various events explaining the observations listed above under the bullet points. Therefore, in line with the scientific literature, the flow of events would be like this:
- Inflammation triggers the activation of HPA axis and release of IL-6 (Ref.1, Ref.2)
- Activation of HPA axis triggers Cortisol production (Ref.)
- Release of IL-6 also triggers Cortisol production (Ref.)
- Cortisol & IL-6 triggers systemic loss of body mass & increased Gluconeogenesis (Ref.1, Ref.2, Ref.3)
- Gluconeogenesis leads to increase of Blood Glucose while "processing" the body mass (Ref.)
- Increased Blood Glucose leads to increase of tumor activity (Ref.)
- Increased tumor activity leads to higher inflammation (Ref.)
Increase of tumor activity, not only induces more inflammation but it also increases the production of lactic acid (Ref.), which next to the breakdown of body mass, represents additional fuel for the activated Gluconeogenesis, leading to additional glucose released into the blood.
So essentially, inflammation triggers an avalanche-like effect in terms of tumor evolution.
Now that we understand the link between various events, we can start to think on how we can stop this chain of events. While we can think of many approaches, including inhibition of inflammation such as discussed in this Reference or in this Video, in this post I will focus on Gluconeogenesis as a very important target to address when fighting cancer. Because it is a key mechanisms that facilitates the above chain reaction, the goal is to understand how Gluconeogenesis works and what are the tools we have in our hands to inhibit the underlining mechanisms, or at least substantially reduce it in order to reduce or stop cachexia and at the same time tumor evolution.
Gluconeogenesis inhibition should be relevant for most cancer patients, regardless of the tumor type. However, the most visible positive impact of Gluconeogenesis inhibition should occur in advanced cancers, since large tumors are expected to strongly rely on that.
Before discussing inhibitors of Gluconeogenesis, I will first dive a bit into the related science. Those who do not have the interests to understand that, may want to skip the "Mechanism" section and go to the next section to find out what are the potential "tools" to interfere with Gluconeogenesis.
Update Oct 2019: It seems that tumors can also release proteins that decrease the insulin sensitivity of healthy tissue, so that they can have more glucose available for themselves. (Ref.) This may me another mechanism to explain the high level of blood glucose level in cancer patients.
- a process through which human body (but also plants, animals, fungi, bacteria, and other microorganisms) can generate glucose from other substrates such as lactate, glycerol, and glucogenic amino acids (e.g. glutamine).
- takes place mainly in the liver
- intensified during periods of fasting, starvation, low-carbohydrate diets, or intense exercise
Gluconeogenesis supports tumor development in two different ways:
- Gluconeogenesis in the liver: Tumors use glucose to produce energy via fermentation (see Warburg effect Ref.). As a result of the fermentation, tumors also produce lactate that is eliminated by the cell (together with some protons as lactic acid) part of which may finally end up in the blood. When Gluconeogenesis is activated, that lactate absorbed from blood (but also the elements resulted from the body mass breakdown as discussed above) can be turned back into glucose inside the liver. This glucose is released back in the blood, and finally absorbed by tumors to further fuel their growth. Next to this process, as discussed above, tumor progression also leads to systemic loss of body mass, that in turn represents fuel for Gluconeogenesis, finally converted in glucose.
- Gluconeogenesis in the tumor cells: In addition to the above, a Gluconeogenesis like process can also take place inside the cancer cell (Ref.). When the cancer cells are deprived of glucose they can directly absorb lactate (produced and eliminated by the fermenting cancer cells) and convert that into energy to support their development. In this case, lactate is absorbed via MCT1 transporter, which is the same transporter that also enables the anti cancer effects of 3-Bromopyruvate. It is important to note, that in contrast to fermentation, the conversion of lactate into energy in this case requires functional mitochondria and access to oxygen. This is why, I expect that these types of cancer cells are typically located at the region towards the tumor surface, or more specifically, closer to the blood vessels.
A key enzyme enabling Gluconeogenesis is called PEPCK (Phosphoenolpyruvate carboxykinase) (Ref.). This enzyme is of two forms depending on its location within the cell:
- PCK1 (the cytosol isoform of PEPCK-C) (Ref.) and
- PCK2 (the mitochondrial isoform of PEPCK-M)
In humans 50% of the liver PEPCK activity is mitochondrial (caused by PCK2), and 50% is cytoplasmic (caused by PCK1) (Ref.). Here is a Figure showing one of PEPCK roles inside the cell https://www.nature.com/articles/s41598-017-11613-2/figures/4
PCK1 is regulated by insulin, glucagon and glucocorticoids (such as cortisol). During starvation, glucagon enhances expression of PCK1 (to maintain the required blood glucose level), while cortisol does that during stress (to activate the body fight mode). Specifically, the rate of transcription of the PCK1 gene is
- increased by glucagon (via cAMP) and glucocorticoids (Cortisol) and
- is inhibited by insulin from the blood (secreted by pancreas when blood glucose is high – used by the body to e.g. manage the glucose spikes after meals)
Therefore, in healthy humans PCK1 activity is inversely regulated by glucose concentrations in the blood (Ref.). In this (Ref.) PhD thesis, page 49, there is a good figure showing the known intracellular signalling pathways leading to PEPCK expression.
Interestingly, the fact that many advanced cancer patients are found with high blood glucose levels, puts them in a similar category with type II diabetes, where the blood glucose level remains high even if the blood insulin level is high. This is in contrast to the normal human body reactions, and it is called insulin resistance. Now that we've got to the point indicating that cancer patients may suffer from insulin resistance, I just searched the literature and indeed there is an association between some types of cancers and type II diabetes (ref.). Consequently, a very relevant subject to be investigated is "insulin resistance", which I think could be the lead towards other approaches to inhibit cancer, such as fasting (known as an approach to reduce insulin resistance). 2DG is a substance that seems to have an insulin reduction potential via an increase in sensitivity to insulin (Ref.). Yet, for now I will park this subject. Also note that the body's mechanism to adjust insulin sensitivity is via the growth hormone (Ref.). For those interested to read more on insulin resistance, here is a very nice article addressing that (Ref.).
Back to gluconeogenesis: since elevated gluconeogenesis is an important marker in the evaluation of type II diabetes, mechanisms that are involved in PCK1 regulation have been extensively studied. One such study showed that the activation of PCK1 transcription has been shown to be controlled by histone deacetylases (HDACs) on different levels (Ref.) Note that HDAC is another well know potential target in cancer (Ref.1, Ref.2) sometimes addressed with the re purposed drug Valproic Acid (Ref.), and it is interesting to find here the connection of HDAC with cancer also through PEPCK .
Another important connection in cancer related to gluconeogenesis has been revealed recently when it has been demonstrated that tumor suppressor p53 down-regulates the gluconeogenic key enzyme phosphoenolpyruvate carboxykinase (PCK1) (Ref.)
PEPCK and its inhibition has also been associated to the tumor inhibition in relation to cytoplasmic NADH build-up: "Proliferating cells must generate lipids and nucleotides, and to do so typically drive glycolysis at a high rate. This leads to a build-up of NADH in the cytoplasm which must be cleared for glycolysis to continue. The glycerol-3-phosphate shuttle is an important sink for NADH that could be significant for the growth of brat tumors. When there is not enough glycerol-3-phosphate produced by glycolysis it is generated by another pathway called glyceroneogenesis. PEPCK is the main regulator for this pathway, and thus a significant contributor to the generation of glycerol-3-phosphate (see Figure)" (Ref.).
Note that glyceroneogenesis requires as a fuel various substances including Glutamine. Reducing an increased glyceroneogenesis that demands more Glutamine from the body, should add additional value in fighting cachexia as well.
Therefore, PEPCK plays an important role in major processes during tumor evolution.
It has been indeed demonstrated, that under glucose shortage PEPCK enzyme becomes activated, playing an important role in tumor adaptation to glucose shortage (Ref.1, Ref. 2). In this context, PEPCK role in cancer has been studied extensively (Ref.1, Ref.2). Here is an overview of the PEK1 activation in various cancer types: https://www.proteinatlas.org/ENSG00000124253-PCK1/pathology And here is an overview on the PEK2 activation in various cancer types: https://www.proteinatlas.org/ENSG00000100889-PCK2/pathology
Now, that we have seen the importance of gluconeogenesis and its key enzyme PEPCK in cancer, the questions is what are the tools available to inhibit PEPCK?
PEPCK inhibitors to inhibit gluconeogenesis
Here is a list of various substances known to be able to inhibit PEPCK:
- 3-mercaptopicolinic acid (MPA), a drug that is the most known inhibitor for PEPCK (Ref.1, Ref.2)
- Hydrazine is a drug often discussed in the alternative cancer treatment world, and it is a PEPCK inhibitor
- Here is a recent Nature paper demonstrating the anti cancer potential (Ref.)
- Metformin – indirect inhibition of PEPCK via
- AMP-activated protein kinase (AMPK) activation – an enzyme that plays an important role in insulin signaling, whole body energy balance and the metabolism of glucose and fats – its activation reduces hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase and glucose 6-phosphatase (Ref.) AMPK is a central cellular energy sensor coordinating anabolic and catabolic pathways. AMPK limits energy consuming anabolic processes, like gluconeogenesis, and facilitates catabolic pathways (Ref.1, Ref.2)
- inhibition of glucagon-induced elevation of cyclic adenosine monophosphate (cAMP)
- GSK-3 inhibitors can reduce the expression of gluconeogenic genes (Ref.) Here is a paper on GSK-3 inhibitors (Ref.)
Update 27.06.2019: Although Methazolamide is not reducing PEPCK, somehow, through mechanisms that are not yet understood, this drug lowers glucose production by the liver, finally leading to reduction of the blood glucose level (Ref.). So this could be a very relevant tool in fighting cancer, specifically those cancers that are more influenced by high levels of glucose and insulin levels in the blood (such as pancreatic cancer and many others).
- Epigallocatechin gallate (EGCG) (Ref.) – green tea extract available as supplement online inhibits glucose 6-phosphatase (G6PC), a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis (Ref.)
Many of the enzymes involved in gluconeogenesis can be visualised here.
Hydrazine: a gluconeogenis (and glyceroneogenesis) inhibitor with anti tumor and anti cachexia potential
Hydrazine inhibits PEPCK (Ref.1,) and it is an inexpensive chemical which is commercially available. Hydrazine sulfate has been studied as an antitumor/antichachexia agent associated with cancer by Dr. Joseph Gold since 1970's (Ref.). Dr. Joseph Gold, a medical doctor suggested that a metabolic circuit exists in cancer patients that allows energy required for tumor growth to be taken from normal metabolic processes in the human body. He suggested, lactic acid from tumor fermentation, amino acids from protein breakdown and glycerol from fat fuel gluconeogenic activity which drains away the energy which normal body processes need to produce and maintain tissue integrity. In turn, this causes cachexia in cancer. In his view, if the circuit could be broken, cachexia would be overcome and the cancer would he deprived of the energy needed to grow.
Hydrazine has been discussed extensively on the web and thus I will not address every point again.
For an extended discussion on Hydrazine, it's anti cancer potential but also it's possible side effects, please read these articles:
- http://www.hydrazinesulfate.org/
- http://scri.ngen.com/hydrazine_sulfate.html.
- https://www.cancertutor.com/hydrazine/
- https://www.canceractive.com/cancer-active-page-link.aspx?n=456
In line with the above discussion on the relevance of PEPCK, if Hydrazine would act as proposed by Dr. Joseph Gold, this substance would have the potential to
- reduce gluconeogenesis leading to
- stop cachexia
- stop tumor evolution by
- reduce blood glucose level that fuels tumors
- reduce the capability of tumors to use lactate as a fuel for growth
- reduce the lipid production inside the tumor cells, that is required for cellular division (Ref.)
Therefore, the use of Hydrazine could lead to the relief of heavy common symptoms related to cachexia found in cancer patients, and would additionally lead to tumor shrinkage via cancer cell starvation.
Indeed, there is a good amount of scientific literature, including clinical trials in humans, suggesting the important potential of Hydrazine:
- Experience of the treatment with Sehydrin (Hydrazine Sulfate, HS) in the advanced cancer patients https://www.ncbi.nlm.nih.gov/pubmed/7499115 The results of Sehydrin (Hydrazine Sulfate, HS) treatment of 740 patients with the advanced, recurrent or metastatic solid tumours of various localizations or malignant lymphomas, for whom all the methods of specific treatment (surgery, radiation, chemotherapy) had been exhausted are presented in this work … Although the objective response in patients with the lung cancer (90%–non-small cell) was only 4%, stabilization of long duration was registered in 22% of cases connected with the impressive relief of heavy common symptoms in 38.5% of the treated patients. Such a subjective response was established in 46.6% of all the 740 cases. The drug given per os was well tolerated by patients in primary and subsequent courses and did not induce myelosuppression or other significant side effects.
- Hydrazine sulfate: a current perspective.
- Anabolic profiles in late-stage cancer patients responsive to hydrazine sulfate.
- Potentiation by clofibrate of in-vivo tumor inhibition by hydrazine sulfate and cytotoxic agents, in Walker 256 carcinosarcoma.
- Hydrazine sulfate in the treatment of cancer.
- Use of hydrazine sulfate in terminal and preterminal cancer patients: results of investigational new drug (IND) study in 84 evaluable patients.
- Hydrazine sulfate in nonsmall-cell lung cancer.
- Enhancement by hydrazine sulfate of antitumor effectiveness of cytoxan, mitomycin C, methotrexate and bleomycin, in walker 256 carcinosarcoma in rats.
- Inhibition of Walker 256 intramuscular carcinoma in rats by administration of hydrazine sulfate.
- Inhibition of gluconeogenesis at the phosphoenolpyruvate carboxykinase and pyruvate carboxylase reactions, as a means of cancer chemotherapy.
- Inhibition by hydrazine sulfate and various hydrazides, of in vivo growth of Walker 256 intramuscular carcinoma, B-16 melanoma, Murphy-Sturm lymphosarcoma and L-1210 solid leukemia.
- Proposed treatment of cancer by inhibition of gluconeogenesis.
- The results of a clinical study of the preparation hydrazine sulfate https://www.ncbi.nlm.nih.gov/pubmed/2198698
In addition, here is a Nature paper published in 2017 showing that Hydrazine can indeed stop tumor growth https://www.nature.com/articles/s41598-017-11613-2
Regarding the administration protocol, according to this article, "Hydrazine sulfate is usually administered orally, with food or immediately before eating. It may also be given by injection. The usual cycle of treatment is 60 mg 3 times daily for 30–45 days followed by a rest period of 2–6 weeks. The cycle can be repeated as many times as desired. Each 60-mg dose is available in capsule form or in 15-mL vials for injection." (Ref.). The same article discusses the safety aspects related to Hydrazine.
The administration protocol and related warnings are also very nicely addressed on this website: https://www.cancertutor.com/hydrazine/
Hydrazine sulfate is widely available, including on e-bay https://www.ebay.com/sch/i.html?_nkw=hydrazine+sulfate&ul_noapp=true. However, since it is cheap if I would like to use it I would better order it from large chemical suppliers such as this one https://www.scbt.com/scbt/product/hydrazine-sulfate-10034-93-2 – we never know what we order from small and unknown suppliers, so I would be very careful with that.
Gluconeogenesis is a mechanism that needs to be addressed specifically in advanced cancer patients that are seeing fast loss of body mass.
One major way to reduce Gluconeogenesis is via oral administration of Hydrazine. This is a tool with great potential. However, since it has also some potential side effects, I would only use it in emergency case, when wight loss is present and can not be inhibited in any other way .
When I find time, I will search for other Gluconeogenesis/PEPCK inhibitors that have less or no side effects.
The central role of hypothalamic inflammation in the acute illness response and cachexia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872506/
STAT3 in the Systemic Inflammation of Cancer Cachexia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867234/
The Surprising Truth About IGF-1 and How to Increase and Inhibit It https://selfhacked.com/blog/the-truth-about-igf-1-top-10-benefits-and-potential-drawbacks/
Vegan proteins may reduce risk of cancer, obesity, and cardiovascular disease by promoting increased glucagon activity – glucagon promotes (and insulin inhibits) cAMP-dependent mechanisms that down-regulate lipogenic enzymes and cholesterol synthesis, while up-regulating hepatic LDL receptors and production of the IGF-I antagonist IGFBP-1 https://www.ncbi.nlm.nih.gov/pubmed/10687887
If the insulin resistant state can increase cancer, then it stands to reason that treatments that enhance insulin sensitivity, such as caloric restriction, could improve cancer. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595327/
Cellular and molecular mechanisms of metformin: an overview https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398862/
Sterol Regulatory Element Binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action http://www.jbc.org/content/early/2000/08/08/jbc.R000017200.full.pdf
Cellular mechanisms regulating fuel metabolism in mammals: role of adipose tissue and lipids during prolonged food deprivation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640658/
Gold J. Metabolic profiles in human solid tumors. I. A new technic for the utilization of human solid tumors in cancer research and its application to the anerobic glycolysis of isologous benign and malignant colon tissues. Cancer Res. 1966 Apr;26(4):695–705. [PubMed]
Gold J. Proposed treatment of cancer by inhibition of gluconeogenesis. Oncology. 1968;22(2):185–207. [PubMed]
Ray PD, Foster DO, Lardy HA. Paths of carbon in gluconeogenesis and lipogenesis. IV. Inhibition by L-tryptophan of hepatic gluconeogenesis at the level of phosphoenolpyruvate formation. J Biol Chem. 1966 Sep 10;241(17):3904–3908. [PubMed]
Gold J. Inhibition of Walker 256 intramuscular carcinoma in rats by administration of L-tryptophan. Oncology. 1970;24(4):291–303. [PubMed]
Ray PD, Hanson RL, Lardy HA. Inhibition by hydrazine of gluconeogenesis in the rat. J Biol Chem. 1970 Feb 25;245(4):690–696. [PubMed]
Gold J. Inhibition of gluconeogenesis at the phosphoenolpyruvate carboxykinase and pyruvate carboxylase reactions, as a means of cancer chemotherapy. Oncology. 1974;29(1):74–89. [PubMed]
Gold J. Inhibition of Walker 256 intramuscular carcinoma in rats by administration of hydrazine sulfate. Oncology. 1971;25(1):66–71. [PubMed]
Gold J. Use of hydrazine sulfate in terminal and preterminal cancer patients: results of investigational new drug (IND) study in 84 evaluable patients. Oncology. 1975;32(1):1–10.[PubMed]
Gold J. Anabolic profiles in late-stage cancer patients responsive to hydrazine sulfate. Nutr Cancer. 1981;3(1):13–19. [PubMed]
Chlebowski RT, Bulcavage L, Grosvenor M, Oktay E, Block JB, Chlebowski JS, Ali I, Elashoff R. Hydrazine sulfate influence on nutritional status and survival in non-small-cell lung cancer. J Clin Oncol. 1990 Jan;8(1):9–15. [PubMed]
Gold J. Enhancement by hydrazine sulfate of antitumor effectiveness of cytoxan, mitomycin C, methotrexate and bleomycin, in walker 256 carcinosarcoma in rats. Oncology. 1975;31(1):44–53.[PubMed]
Chlebowski RT, Heber D, Richardson B, Block JB. Influence of hydrazine sulfate on abnormal carbohydrate metabolism in cancer patients with weight loss. Cancer Res. 1984 Feb;44(2):857–861.[PubMed]
Tweedie DJ, Erikson JM, Prough RA. Metabolism of hydrazine anti-cancer agents. Pharmacol Ther. 1987;34(1):111–127. [PubMed]
Stress and Glucose metabolism: A Review https://www.peertechz.com/articles/stress-and-glucose-metabolism-a-review.pdf
This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.
Please read an extended version of the Disclaimer here: https://www.cancertreatmentsresearch.com/?page_id=1794

subset: commoncrawl


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1967 505 - Rigid
€80.00 €160.00
We have run out of stock for this item.
The Levi's Vintage Clothing 505 1967 were the brand's first pre-shrunk dry denim jeans. Created in Levi's archive wash, the Rigid is made from Levi's red selvedge denim, offering durability and comfort.
- Straight Slim Fit from Thigh to Ankle
- Slight Taper Towards the Hem
- Cone Mills 12oz Red Selvedge Denim
- Pre Shrunk Denim
- Zip Fly
In the photos, Sam is 6'2"/189cm tall, waist size 32" and wears a size 32/32.


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Police in East Lothian are appealing for witnesses and issuing a security warning following a series of thefts from sheds in Musselburgh.
Between 22nd August and 29th October around 40 units were entered in the area resulting in various electrical items, gardening equipment and bicycles being stolen from inside.
In addition, over 20 vehicles were broken into during this time, including 4 work vans, and quantities of tools, clothing stock and food were taken.
A further four cars, three motorcycles and five bikes were also stolen from outside addresses within the town and officers are now urging the public to protect their properties and possessions against would-be thieves.
Inspector Andy Harborow said:
Officers continue to carry out local enquiries to identify those responsible for these recent offences and anyone who can assist with our investigations is asked to come forward.
Similarly, anyone who witnesses any suspicious activity in or around a property, or who believes they are being offered stolen property for sale is also asked to contact police immediately.
Our communities are reminded to take simple security precautions to safeguard their homes and deter criminal activity.
All sheds and outbuildings should be locked and secured when not in use and where possible, alarms and motion-triggered lighting should be considered.
When leaving your car, van, bicycle or motorbike unattended, do so in a well-lit area and ensure the vehicle is locked with all items of value removed or stored safely out of sight.
Anyone wishing more advice on crime prevention can contact their local policing team.
Those with information on these crimes can contact Police Scotland on 101 or alternatively, the charity Crimestoppers on 0800 555 111.


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Nate's Monday Morning Message
Welcome to this week's edition of Nate's Monday Message! Life is all about taking chances and going for your dreams. Don't let anyone hold you back! It may not be their dream, but if it is yours then go for it and give it your all. Obstacles and challenges will get in the way. People will try to throw you off or hold you back. It will not always go as planned. But you must be strong enough to stand up for what you believe and fight with all the might and vigor you can muster! If you want it bad enough then go for it. Burn the bridge and go all in. Make life what you want it to be. In the end it's yours to make with it what you want. Dream big…work hard…help others…be happy. Let's make it a great week!
There was once a boy who wanted to seek the secret of success. One day he approached a wise man living up in the mountain. When he found the wise man at the hut, he asked "Wise man, can you tell me the secret to becoming successful in life?" The wise man was silent for a bit. After a moment, the wise man led the boy down to the river. They kept walking into the river until the boy was fully submerged in the water. The boy struggled and the wise man did not help him. The wise man held his head under the water. After a while, the wise man pulled the boy out of the water and headed back up to the mountain. At the hut the wise man asked the boy what he desired most when his head was submerged in the water. To this the boy quickly responded, "Of course, I wanted to breathe, you old fool!" To which the wise man replied, "Son, if you desire success as much as you wanted to breathe, then you would have found the true secret of success."
Success is a matter of choice. If we have enough strong reasons, there is nothing we cannot do. Once we have the reasons, we will surely find the way to do it.
"Happiness is not something you postpone for the future; it is something you design for the present." - Jim Rohn
"Setting goals is the first step in turning the invisible into the visible." - Tony Robbins
"Success is no accident. It is hard work, perseverance, learning, studying, sacrifice and most of all, love of what you are doing or learning to do." - Pele
Nate Martinez, RE/MAX Professionalswww.joinremaxprofessionalsaz.com firstname.lastname@example.com


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Abel to Yzerman
Bucci And The Griffs
by IwoCPO on 11/20/06 at 09:20 PM ET
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So what's going wrong? Well, everything, apparently. While Howard hasn't been horrible, he's not playing like we know he can-like he did last season. Jimmy was outstanding during the playoffs, but he doesn't have the same confidence. Liv has been terrible. He lets in weak goal after weak goal, and when he does that, it seems like the team gets frustrated and self-destructs. The offense is not scoring and the defense is not helping the goaltenders.
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About Abel to Yzerman
Welcome to Abel to Yzerman, a Red Wing blog since 1977. No other site on the internet has better-researched, fact-laden and better prepared discussions than A2Y. Re-phrase: we do little research, find facts and stats highly overrated and claim little to no preparation. There are 19 readers of A2Y. No more, no less. All of them, except maybe one, are juvenile in nature. Reminding them of that in the comment section will only encourage them to prove that. Your suggestions and critiques are welcome: firstname.lastname@example.com


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Which service will you likely use?
An uberX car can pick you up in ~4 min.
Distance between Elizabeth Vale and Adelaide is approx. 14.6 miles (23.5 km) with 29 min travel time.
This Uber estimate from Elizabeth Vale to Adelaide
was updated
911 days ago.
Update the estimate to see the real-time fare prices with Uber in .
Did you know that we have all the fare rates for Uber Elizabeth Vale SA? See all the taxi services and find your next cheap ride.* Taxi fare estimate may vary due to weather and traffic. Our estimates do not include any discounts or promotions.


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Gemma Carder
Hi, I'm Gemma, the research manager at World Animal Protection.
I care deeply about all aspects of animal welfare. As a scientist, I believe that we need robust evidence to inspire the people and groups who have the power to make positive change for animals. Having knowledge of the emotional lives of animals is key to help us understand what they need and how we can protect them. It would be hard to make lasting change for animals without truly understanding them.
My blog will bring you some surprising facts and the latest scientific findings about the emotional lives of animals.


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At a divisive time in the country, it's important to remember that friendship between individuals with different political views is possible.
In fact, current and former politicians consistently put their differences aside and reach across the aisle. We saw it among members of Congress after a recent shooting, and we saw it again on Thursday, as former presidents Bill Clinton and George W. Bush came together for a discussion at the Bush Presidential Center in Dallas.
The event, moderated by David Rubenstein, was part of a graduation ceremony for members of the 2017 Presidential Leadership Scholars Program. Clinton and Bush discussed everything from family to what makes a great president.
The pair quickly joined Barack Obama and Joe Biden, as well as Justin Trudeau and Emmanuel Macron, among our favorite political friendships, as Bush called Clinton his "brother with a different mother."
Clinton explained of their cooperation, per CNN, "When I left office, I told him, I said if I can ever help you, I'll do it. If I can't in good conscience, I won't, but I'll never embarrass you in public ... I said I may have to make some comment that disagrees with some policy of yours, but I will always do it respectfully, and I want you to succeed."
Humility was one of the qualities both men agreed were important in a great president. "If you want to be president, realize it's about the people, not about you," Clinton explained. "You want to be able to say, 'People were better off when I quit.' ... You don't want to say 'God, look at all the people I beat.'"
Bush echoed this sentiment when he praised Clinton for being "humble in victory" against his father, former President George H.W. Bush, in 1992. According to NPR, the younger Bush also shared that he reached out to Clinton for advice in the early days of his presidency.
There were also plenty of playful moments both during and outside of the presidents' discussion, including the above photo of Clinton peeking out between statues of the two Bushes. The image has gone viral with funny comments on Twitter. "Everything's bigger in Texas," wrote Angel Ureña, Clinton's press secretary.
According to People, Bush and Clinton even talked about their grandchildren, jokingly setting up a rivalry when Clinton told an anecdote about his granddaughter singing "Happy Birthday" to her father.
"Can your granddaughter sing 'Happy Birthday' in Mandarin?" Bush asked. "Mine can."
Clinton's response? "No, but she can in Spanish."
Many of us, whether we're in politics or not, could learn something from this friendship.
Watch Bush and Clinton's full conversation in the video below:


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2Cents is an audio vending machine that serves the user a randomly chosen audio clip contributed by other users. Hanna Kang-Brown, Silva Shih, Angie Bond and I produced it as our final project for Clay Shirky's Designing Conversational Spaces.
To operate the device, a user puts in coins to make the audio play. The coin receiver is hooked up to a Raspberry Pi multi-controller. In was designing with the ITP floor in mind, but it could easily be adapted for other locations. There is a button for each of the four types of audio clips available (Encouragement, Motivational Ass-Kicking, Wisdom and Random). We imagined the user to be someone working on the ITP floor who is taking a break from their work and can benefit from hearing someone offer perspective or advice.
The audio files are handled by Twilio. We provided a phone number so that anyone can call and add additional voice recordings. The number is set up like a normal voice mail system, asking users to press the number of the category they want. The files are stored in a PHP/MySQL database. Most of the other functions connecting Twilio and the Raspberry Pi are written in Python.
2Cents came about after we tried and user tested a number of different ideas. As a group, we were all interested in working with audio in some capacity. Audio is an intriguing format, with a unique power different from both text and video. It's intriguing how speakers can give off certain clues about themselves simply through their tone and way of expressing themselves, not simply their word choice.
Our first ideas was to create a confession booth on the floor. We thought that people were more likely to want advice or feedback on a personal issue rather than to confess to something (but who knows). But when we looked into the idea, we saw that it had been done by enough other artists (including Candy Chang) that it seemed less compelling.
We next tried adapting the project into something briefly called Talk to the Ear, a physical installation piece that could be situated at different points around the city. But we had a tough time agreeing on specifics for it.
Our next iteration was called RadioTwitter. Like Twitter, it was focused on short bits of media (we experimented with recordings of 8-12 second sound clips). We thought about creating a channel where people would answer a topic or question of the day. The audio would be played back on a website in the order recorded. We assumed that people would listen to the previously recorded clips and then start offering responses to earlier clips that would appear later in the feed.
We first tried user testing this idea by simply getting a microphone and asking people to come over and speak with us for a few minutes. It being ITP, our classmates were willing to help out and do their part for our project. But we saw a trend quickly develop in that very few people wanted to actually listen to other people's recordings. They simply wanted to answer our question and be on their way. We tried different types of questions as cues, but none worked better than others to address this problem.
Uninspired by our user testing, we brainstormed again and decided on the 2Cents idea. We moved quickly from that point in narrowing in on our idea and planning the implementation after that. We initially thought we would built it with an Arduino, ITP's default micro-controller. But we heard that the Raspberry Pi was designed with an Ethernet jack and audio output built-in, so we decided to give it a try.
The biggest challenge of the build was that no one on our team is a particularly strong coder. The Python, PHP/MySQL and terminal commands were all a challenge. We ended up relying on the goodwill and knowledge of our classmates, especially Sean McIntyre, and my friend D'Arcy Saum in getting the prototype working (thanks, guys!). At the final presentation, the industry guests who were invited to give us feedback were extremely positive on the results. They liked the playful nature of it and the simple design. Clay also made note that he was glad we tried user testing our ideas before building anything, something that contributed to the final success of the project.
Here is a video that my teammate Silva produced: watch?v=uE6B9fKXbxI&feature=youtu.be


text: Share: Comments Print August 6, 2014 at 2:42 PM Poll: Do you want the Storm to make the playoffs? Posted by Jayda Evans San Antonio lost its past two games and Los Angeles lost to Tulsa on Tuesday, keeping the door cracked for Seattle to make a WNBA-record 11th playoff appearance. The Storm (10-20) has four games remaining and is 3.5-games behind the Stars (13-16) and Sparks (13-16) for one of the final two playoff spots in the West. Seattle owns the tiebreaker against San Antonio, winning the regular-season series 3-1. The Storm has one more game remaining in LA, but is already down 0-4 in the regular-season series to drop that possible head-to-head tiebreaker. But do you really want the Storm to advance? Naturally, no player wants to be on the first roster since 2004 not to advance to the postseason. It would be a first in G Tanisha Wright's career, drafted with the No. 12 overall pick in 2005. PG Sue Bird has only not made it to the postseason once in her 13-year WNBA career and that was in 2003. This season has been rough. It's the common word used among the team after dragging through a seven-game losing streak. Attendance is dismal. And the truth is, Seattle has lost in the postseason opening-round eight times. Not a glamorous feat compared to Atlanta, which has at least advanced to the WNBA Finals three times but never won. Minnesota has also advanced to the WNBA Finals three times, winning two championships. Will anything be gained from a possible Seattle opening-round loss to Phoenix (24-4) or Minnesota (23-6) this season? Or would the Storm benefit more from being in the draft lottery? UConn star Kaleena Mosqueda-Lewis is the projected No. 1 pick for the 2015 WNBA draft. Vote here: Take Our Poll Comments | More in Polls, Storm, WNBA Draft | Topics: Sue Bird, Tanisha Wright, UConn


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Benefits Of Home Health Care Agencies
If you or a relative have health needs that are not easily met at home by you or your family, instead of turning to a nursing home, you might want to consider the services that a home health care provider can offer. It's important to keep in mind that there is a difference between directly hiring an individual to care for your needs and hiring an agency to do so. There are many reasons why people choose to take advantage of home health care agencies. Below are just a few of these.
You Avoid Employer Responsibilities
If you choose to directly hire a nurse or home health care aid, you have to assume the responsibilities of being this individual's employer. As a consequence, you're going to have to pay payroll taxes, unemployment insurance, workers compensation and liability insurance. If this employee is injured while providing care for you or even while traveling to or from your home, you are both financially and legally liable. By hiring an agency, you shift all of these responsibilities onto someone else.
You Can Trust the Caregiver
Unless you pay to have someone perform a criminal background check on all the health caregivers you're considering directly hiring, you will have no way of knowing just what kind of person you're allowing in your home. A home health care agency carries out a complete background check (including both criminal records and credit history) on any employee who will be entering your home.
You Get Security and Backups
If you hire someone directly and this person either steals from you or harms you, you have no recourse other than turning to the police. On the other hand, a home health care agency is legally obligated to follow up any allegations of theft or abuse. In addition, if the health care provider the agency has been sending is injured, sick or has to change jobs, the agency will be able to immediately provide a replacement. If this happened with a direct hire, you would have to start the whole hiring process all over again.
Continuous Supervision and Training
When you hire directly, the responsibility for ensuring that the health care provider is properly supervised and is carrying out continuous training falls on you. By contrast, established home health care agencies have the knowledge, experience, resources and training to guarantee that any of their employees are fully trained in all the tasks they will be required to do.
If you're considering health care at home, keep these benefits in mind as you talk to companies like Carolina East.


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Online Teaching Jobs – What Qualifications Do I Need?
The internet and has opened up the teaching profession, with new opportunities for both teachers and learners. Online teaching jobs are now widely available, with qualified teachers and online tutors able to help learners in a variety of ways. Online teaching jobs can be found to suit the service provider's abilities and preferences, offering a new set of career paths in the field of education.
If seeking online teaching jobs is a new avenue for you, the first question you will ask will probably be 'Do I have the qualifications?', or 'What qualifications do I need to have to be an online tutor? That will depend partly on what and whom you plan to teach.
Do I need formal qualifications?
For some online teaching jobs, some agencies and learners will require degree-level qualifications in a subject area, and some will also require a teaching diploma or similar certification. If you want to become an online tutor for undergraduate students, a Masters degree in your subject is likely to be a minimum requirement. Membership of a professional body may also be helpful in establishing your competence.
Formal qualifications will be a great help to anyone seeking online teaching jobs but there are openings for people who want to become online tutors. As well as teaching subject content, there are openings for online tutors to help school-age learners with homework or with a revision or test prep routine. Though that will typically require some subject competence, the online tutor's role will be partly supervisory, helping the learner to keep to a schedule and assisting them with independent working (not doing the work for them!). Student teachers may find openings of this kind for online tutors, even though they have not yet completed their studies.
Alternative or equivalent qualifications
In some cases, demonstrable experience can be as good as formal qualifications in a subject or in teaching itself. For example, people who have successfully home-schooled their own children may be well qualified to become online tutors for other people's children.
Proven expertise in a subject can also be a substitute for a degree or diploma. Online teaching jobs assisting adult learners are plentiful. Many of these learners are not seeking to acquire qualifications, but take courses or seek online tutoring as a matter of self-development. Someone wanting online tutoring in water color painting or photography may get what they need from an established artist or hobbyist, regardless of whether they have the paper certification.
When qualifications are vital
Learners seek online tutoring for a variety of reasons. In some cases, they will be looking for very specific qualifications. One scenario in which parents seek to hire online tutors is when children are struggling in school. Online tutoring of children with learning difficulties will typically require the online tutor to have specialist training, documented experience and perhaps testimonials as well.
Signing up for online teaching and online tutoring jobs
Some agencies advertising online teaching jobs have particular specifications with regards to qualifications, the hours an online tutor will be expected to put in per week, and so on. Others are more flexible, providing a service that helps learners to find an online tutor to suit them, with details of hours, payment negotiable between the parties.
Of course, those seeking online teaching jobs will find more opportunities if they have formal qualifications as well as a track record of experience in their subject or educational field. However, online tutoring is not only for graduates with diplomas in education and would-be online tutors with appropriate skills are likely to find a niche for them.
Tutoring Services LLC. Helps to find a tutor, online tutors, online learning benefits to students of schools, colleges & universities. Offers opportunity of online tutoring jobs for tutors to find resources online & offline.


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March 23, 2009
Forty Five Years of Marriage
"What counts in making a happy marriage is not so much how
compatible you are, but how you deal with incompatibility."Leo Tolstoy (1828-1910)
April 11th will mark our forty-fifth wedding anniversary. Forty five years may not be fifty, but it is a good long time. Neither of our parents made it this far. Death intervened.
During the past forty five years we have been homeless (for six months we hung out at Caroline's parents apartment in New York, early in our marriage) and have had seven residences, eight if you include a boarding house that became home for a couple of months in late 1965.
We were married before I finished college, a quaint concept in today's world of thirty-something marriages and two family incomes, but not uncommon in those pre-historic days. Marriage is viewed differently today. For one, people marry at a later age. The population of the United States has increased 58% since 1964, while weddings are up a mere 23%. On the other side of the ledger, the divorce rate is up 130%. It makes one wonder, does wisdom diminish with age?
Other facts, while irrelevant to the subject of forty-five years of marriage, are of interest. GDP during those years increased twenty-five times, while the DJIA is up about nine times. In 1964 Lyndon Johnson was in the White House and Vietnam was just beginning to heat up. A first class stamp cost a nickel. Civil Rights marchers were murdered in Mississippi. Northern Dancer won the Kentucky Derby and the Beatles appeared on the Ed Sullivan show. If it seems like the distant past, it was.
I met Caroline on New Year's Eve 1961 at a, now defunct, ski area in southern New Hampshire, Temple Mountain; we were introduced by my sister, Mary. We saw each other that evening and within a matter of weeks knew we wanted to marry. I was twenty-one at the time. Two and a half months after meeting, in a ski lodge in North Conway, N.H. I asked Caroline to marry me; she accepted. A few hours later she broke her leg on Wildcat Mountain, during what would prove to be her last trip down hill on skis. (It turned out she had broken an ankle skiing each of the prior two years.)
We grew up very differently, Caroline on Park Avenue in New York and I on a little farm in a small town in New Hampshire. But we were not quite as different as a superficial view might appear. For example, both of our fathers had Harvard in common; Caroline's father graduated from the law school and mine from the college. Caroline had friends in Boston, where she was then living, whose parents were friends of my parents. Nevertheless, the differences were quite obvious. The sidewalks of New York differ from the rocky fields and pastures of New Hampshire. To enjoy the outdoors meant a trip to the Park for Caroline, while I would saddle a horse and take off over miles of dirt roads. My wife had only to step outside to enjoy the cultural advantages of New York, from Broadway to the Museum of the City of New York, from the Stork Club to the Metropolitan Opera. In Peterborough we had the MacDowell Colony, the Guyette Museum and, during the summer, the Peterborough Players. Caroline's family always had a dachshund, while mine had several dogs of varying breeds that lived along side of cats and a barn full of horses, goats, chickens and two peacocks. I was one of nine children while Caroline had a brother.
Following college, and before the start of my first 'real' job, we took $2000 and went to Europe for eleven weeks. We had rooms booked in Paris for the night we arrived and for the night before we left. The other seventy-five nights we left to chance. Arthur Frommer's, Europe on Five Dollars a Day, a rented VW bug, a map, sleeping bags, some Travelers Checks (no credit cards) and a couple of small suitcases were our sole companions. It proved to be a great time and making the trip after almost a year of marriage – we celebrated our first wedding anniversary in Vienna – proved fortuitous. The physical attraction of marriage, while still exciting, was no longer all consuming, so we were able to get to know one another far better and become friends, as well as lovers.
In 1974, three years following our move to Greenwich with three small children and seven years after entering the securities business, Wall Street went into a severe bear market. It had been a long time coming. The DJIA had neared 1000 in early 1966. In the intervening eight years, the Averages had fallen, risen, fallen and risen, but in 1974 stocks went to twelve year lows. On May 1, 1975 fixed commissions were abandoned in favor of negotiated rates (a plan that ultimately proved very positive, but at the time was devastating) and the commission business slowed markedly. With two children in private schools and a third in the wings, a mortgage on a house beyond our means, our marriage suffered a strain. There were moments when I – and I'm sure Caroline, too – sympathized with the lines of Neil Lindores' uncle in Andrew Greib's The Return of John Macnab,
"How ill advised it was, and rash, to start upon this foolish dash!"
My income virtually disappeared; we were forced to sell the house off Round Hill Road, send to my mother in New Hampshire a couple of horses and goats, and move to another house with less land about two miles away on Lake Avenue. But financial hardship brought determination and reinforced our marriage. The 1974 recession caused a lifestyle change, not only for us, but for others on Wall Street. In the early 1970s I would drop the children at school and catch the 7:40AM to New York, arriving at the office a few minutes before 8:30AM – a leisurely pace. The train was crowded and reflected life on Wall Street in those halcyon days. However, it wasn't long before the 6:00AM became the train of choice for me and for hundreds of commuters. Being at your desk by 7:00AM became the norm. The children took the bus to school.
The years went by; the children grew and did well. Wall Street recovered and I was fortunate to have found work I enjoyed and which treated me well.
The focus of Caroline's attention has been, since our eldest was first born, on the children. She has showered them with love, provided practical advice to their inquiries; she has acted as a sounding board to them. The have been her "raison d'être."
Within a year of one another they all married. Once the three of them set up their own homes our lives re-set to our years before children, giving us time for re-discovery. However, after three years they began producing their own families and now the grandchildren are the fortunate beneficiaries of Caroline's love and wisdom. I revel in the love they bestow on her. My admiration grows and the foundation of our marriage becomes more deeply embedded.
There is no moral or lesson, in this short essay. It is almost impossible to foretell whether a marriage will work or not. A lot has to do with luck. Certainly, it is something that needs attention. Compassion, respect, understanding and of course love play big roles. One partner may be the counselor on Monday and the counselee on Tuesday. Staying married does not necessarily make one a better person. Two very fine people may find themselves incompatible and the best course may prove to be divorce. I revert to my earlier premise: luck plays a big role. Caroline and I have been fortunate and we know it. There have been times of angst. There have been moments of doubt, but happiness and satisfaction have dominated. The decision to marry involves a bet on the very long term. We both realize the role of coincidence – had we not met when we did our lives may have taken very different paths. Those paths might well have led to happiness, but the question of "what if?" is not one that consumes us. We did meet. We were young and took a chance. It worked.


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Pima Community Access Program is excited to partner with CMS for the Connecting Kids to Coverage Outreach and Enrollment Grant
Michal Goforth, Executive Director, Pima Community Access Program
Pima Community Access Program is honored to receive this Connecting Kids to Coverage Outreach and Enrollment Grant. With nearly $1 million from the grant, made possible by the Affordable Care Act, we will continue our longstanding efforts to ensure that children and families in our communities have access to the health care they need.
We know from experience that application assistance delivered by trusted members of the community is essential. Working with the Arizona Medicaid agency, we operated a special hotline to help enroll children into Arizona's Children's Health Insurance Program (CHIP). Through that collaboration, we were able to access key data systems so we could answer questions, troubleshoot and expedite difficult cases.
As a result, in only 6 months, we were able to help enroll 26,000 children who had been waiting for coverage – and the state's program will now be enrolling an additional 33,000 children.
This kind of help means the world to families in our community. Our staff recently took a call from a mother whose child had a serious unexpected illness. That child was in need of hospital treatment but was not enrolled in CHIP health coverage, even though the she was eligible. Because of our direct connections, we were able to help her enroll immediately. Not a second was wasted.
By preparing community organizations for the significant changes that will be taking place with the application and enrollment process, we are building on these vital lessons.
Under the grant, our organization and our 16 partners will provide in-person and web-based training for trainers who will, work with an array of 600 community organizations, schools, government agencies and faith-based groups. The project will provide tools that organizations can use to motivate Arizona families to enroll and maintain enrollment in the health insurance option that best meets their needs.
We are excited for this new opportunity to help enroll children of Arizona.


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Wednesday's Mini-Report
Today's edition of quick hits:
* Crisis in Ukraine: "Hints of turmoil within the government arose Wednesday as a day and night of fighting that left at least 26 people dead slackened to a standoff on the streets, and U.S. and E.U. leaders condemned the violence."
* It's spreading: "The security authorities in Ukraine offered the first indication on Wednesday that the deadly political violence afflicting Kiev had spread far beyond the capital, announcing a crackdown on what the Interior Ministry called 'extremist groups' that had burned down buildings and seized weapons nationwide."
* Sanctions on the table: "Congress is putting pressure on President Obama to immediately punish the Ukrainian government following the deaths of at least 25 people in overnight violence. Both the House and Senate are considering new sanctions that could come up for a vote soon after Congress reconvenes next week."
* Another spill in West Virginia? "West Virginia regulators were on the scene today of another coal-waste spill, this one coming from a former slurry impoundment that had been reopened by a company re-mining the site for leftover bits of coal."
* Look for more on this North Carolina story on tonight's show: "The federal inquiry into a spill of toxic coal ash into the Dan River is expanding to other similar ponds throughout the state and to specific state employees, according to federal subpoenas obtained by WRAL News through a public records request."
* Keystone: "A Nebraska judge ruled Wednesday that the state violated its constitution when it allowed the governor to approve the route of the controversial Keystone XL pipeline, a decision that could significantly delay the $5.3 billion project."
* Impressive enrollment: "Well before the March 31 deadline to buy insurance, California announced Tuesday it has already exceeded its 2014 enrollment goals for its health care exchange. By the end of January, 728,410 people had enrolled in private health plans through Covered California, and 100,000 more signed up in the first two weeks of February. About 26% are 34 and younger."
* New Jersey: "More than five months after several lanes leading to the George Washington Bridge were closed in an apparent act of political retribution, the Port Authority of New York and New Jersey apologized to travelers on Wednesday."
* This would be quite a surprise: "Wal-Mart Stores Inc., the largest private employer in the U.S., said it's looking at supporting an increase in the federal minimum wage, breaking with business and industry groups that oppose such a measure."
* Erik Wemple raises a compelling question: "When newspaper columnists and reporters stick with a story no matter what, they're heroic and persistent. When TV networks do the same, they're bloated and irresponsible. What gives there?"
Anything to add? Consider this an open thread.


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The Party of Workers and Unemployed is an alliance of workers and unemployed citizens who lost their jobs because of the automation of production, trade and other spheres of the economy, because of overproduction crises and other causes. Technical progress and the further development of productive forces lead to the fact that the number of unemployed throughout the world will only increase every year.
This union is aimed at the elimination of the exploitation of man by man and the socialization of the means of production (enterprises), the subsoil and the establishment of a just society, the aim of which is to maximize the satisfaction of all the needs of each member of society, and not to receive profits, as is currently the case.
1.1 Replacing representative democracy in a straight line.
1.2 Convening of the People's Assembly of all citizens.
1.3. Elimination of the post of the president and parliament, and the transition to a people's republic with direct democracy.
1.3 Sessions of the Peoples of the Republic will be held 2 times a year, for participation in which all adults will be admitted. Open voting on the adoption of laws, budgets, and discussions will take place with the help of all modern means of communication: the Internet, cellular communications, etc., as well as on the ground.
1.4 Once in 3 years, open elections will be held for employees of the Ministries. The work of the ministries will be transparent and accountable to all citizens. Citizens can recall and fire ministers and other employees.
1.5 Creation of conditions for mass involvement of workers in the management of the state: reduction of the working day, etc.
2.1 Introduction of unconditional basic income
The introduction of unconditional income is a necessary measure of support for citizens against the background of automation of various sectors of the economy and the displacement of people from production, transport, trade, etc.
The amount of income should be lower than the wages of workers, but sufficient to meet the minimum human needs (in housing, food, etc.) This will stimulate the unemployed to get employed in those industries in which there has not yet been a substitution of people for automation and robots. This will stimulate a person to engage in science. The state will support the people engaged in science in every possible way. Education will be completely free, and unconditional income will be distributed to students. Science will again take a special place in society. The salaries of scientists and academicians will be higher than those of other members of society.
2.2 Nationalization of natural resources, subsoil in public property
With the sale and use of natural resources, all citizens should receive cash payments. Similar practice exists in the oil Arab countries, most of whose budget is replenished with the sale of oil and gas. Each citizen is given a certain amount from birth, citizens are exempted from paying utility bills and so on.
2.3 Nationalization of monopolies: large industrial and agricultural enterprises.
The socialization of monopolies will allow all the profits to be channeled into the development of the country's economy, and not into the pocket of the oligarchs. This will systematically reduce prices for goods and products due to lower costs of production and technology development.
2.4 Nationalization of banks.
2.5 Providing benefits to small and medium-sized businesses.
Real support of small and medium-sized businesses by the state will allow them to develop, rather than serve as an appendage of monopolies.
2.6 Progressive taxation
In all civilized countries there is a progressive tax. Progressive taxes were also available in the USSR.
2.7. Introduction of a non-taxable minimum. Gradual exemption from taxes of all citizens and transfer of all taxes to a monopoly.
A similar practice existed in the USSR. Most of the citizens were exempt from taxes, there was a non-taxable minimum, the rest paid 1-2% of their income, not 13%. The highest 10% of their incomes in the USSR were paid by highly paid scientists, academicians, theater and cinema figures and others. 85% of the budget revenues of the USSR were the incomes of socialist enterprises, and only 8% of taxes from citizens.
2.8. Reduction of the working day from 8 hours to 6 hours.
To reduce the working day to 6 hours suggested in the distant 1919 in the program of the RCP. At times the USSR introduced a 7-hour working day, during the Second World War, the working day was again increased, under Khrushchev and Brezhnev, the working day did not decline despite all the conditions created for this.
In the conditions of general automation and robotization, it is necessary to reduce the working day to 4 hours, where possible, provided that the payment is kept as a full day. This will make it possible to employ two people instead of one working 8 hours, which will slightly reduce unemployment. An hour of free time a person should devote to the training of public administration.
2.9. Establishment of electronic-machine tractor stations (EMTS) for servicing and repairing transport and private equipment (farmers) and state agricultural enterprises at the expense of the state.
Buying and renewing agricultural machinery is ruining farmers and small agricultural enterprises.
3.1 Inclusion of the right to free food in the Constitution. Providing this right by creating an extensive network of grocery banks, where everyone can be free-to-date with products.
Private food banks or food banks exist nowadays in the US and in the EU countries, their number is increasing every year.
3.2 Creation of canteens, cafes for free catering.
Reducing the cost of production of products allows you to create a network of canteens in the country with free public catering.
3.3 Free use of public utilities.
Nothing so ruins Russian families as high utility bills. Some families give a third or even half of their earnings for paying for utilities. The introduction of free use of communal services was mentioned in the distant 1961. Thus, the program of the CPSU, adopted in 1961, indicated the introduction of free use of communal services after 1980, by this time it was planned to finally create a material base for communism. In the USSR, payment for utilities was a mere penny.
In the modern world in some oil Arab countries there is no payment for utilities, since part of the revenues from the sale of oil and gas covers these expenses for all citizens. In some countries, for example, in Finland, the state pays 80% of the costs for utility payments to citizens with low income.
3.4 Release of citizens from debts, mortgages.
4.1 Introduction of elections and procedure for recall of judges.
4.2 Replacement of the penal system with a system of educational measures.
Today it is quite obvious that any phenomenon in our life has a scientific explanation. Causes of mass crime today – the difficult economic situation of the country, ripped by the oligarchy. Members of the government, oligarchs and their servants will be the last to be in prison for their crimes.
5.1 Providing free housing to all who need it.
5.2 Repair of apartment buildings at the expense of the state.
6.1 Armament of workers for protection of public property, subsoil and resources.
6.2 Gradual replacement of people with cars and military robots, drones and drone.
7.1 Provision of free, public medicine.
8.1 Free education
8.2 Separation of church from school


text: kontakt 1. Kontakt TLS/SSL 1.2 verschlüsselt Akzeptiert Anhänge bis zu 15 MB. / Attachments up to 15 MB. subject message respond to [x] None file [x] PGP-Mail erich[at]moechel[dot]com Public Key 0x2440DE65 fingerprint: A564 1457 71C3 E907 6D78 429E 76F3 C66E 2440 DE65 Signature OTR key. Jabber account on request., as well as Cryptocat and Minibox based communications. OE3EMB radio communications Currently QRV from 40 to 6 Meters in SSB. Drop me mail for a sked on a band of your choice. I am also available via echolink node OE1XUU Vienna [dial: 6406] after 22.00 UTC More on OE3EMB and the junkyard antennae project soon on QRZ.COM QSL card design by Zazie, production atrox.


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Cozy up with a cup o' joe while lounging in this coffee-filled top and flannel jogger pajama set. You might like the matching fancy cheese flannel jogger set or the matching fancy coffee classic pj set.
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Practicing Higher Order Thinking (HOT) skills outside of school will give kids the tools that they need to understand, infer, connect, categorize, synthesize, evaluate, and apply the information they know to find solutions to new and existing problems.
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Source: http://www.readjunk.com
Posted by Bryan Kremkau
St Patrick's Day has passed this year but that doesn't mean you can't listen to some Celtic rock music still! The Rumjacks hail from Australia, but they don't sound like it at all. The band is heavily influenced by The Pogues and Roaring Jack (obviously). Members of the band formed in 2008 when their other bands (the Laundrymen, Catgut Mary) broke up. I've heard many a Celtic rock band in my day, and these guys definitely stand out from the bunch.
I'm reviewing both their releases since each EP only contains 5 or 6 tracks each. Their newest release is "Hung, Drawn and Portered" and it's a fine EP. It makes me want to hear more after hearing it. The first song on that album is "The Plantin' O' Kitty Randall" is an awesome track that sounds like a bunch of pirates are singing it. I notice that many bands cross over into the pirate territory when doing Celtic music sometimes. I don't mind it, pirates rock! The accordion playing is top notch, and the singing is really good as well. The last track on the EP is a cover of "I'll Tell Me Ma" and I can never get enough of hearing different covers of that traditional song.
Band Link: www.myspace.com/therumjacks
The Celtic Force – Visit our website: www.thecelticforce.com


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Welcome back Study Abroad Alumni
The Office of International Programs welcomes you back from study abroad! We hope that your time overseas enabled you to grow personally and intellectually, develop new friendships, learn about another culture, discover new interests and travel to other countries. We encourage you to think of your study abroad experience as the beginning of a life-long global journey.
Study Abroad Ambassador program
We hope that your study abroad experience has inspired you to encourage other IC students to go abroad! If you would like an opportunity to share your overseas experiences and stories with other students, you should become a Study Abroad Ambassador. The Ambassadors are returned study abroad students who are involved in helping with peer advising, study abroad information sessions, orientations and other events that promote study abroad on campus. Serving as an ambassador requires only a minimal time commitment, but it will allow you to talk about your experiences with an interested audience and meet others who have studied abroad. If you are interested in becoming a Study Abroad Ambassador, please complete the Ambassador application.


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We use cookies to optimise your experience on our website. iShares merchandise is probably not suitable for all buyers and BlackRock does not guarantee the efficiency of the iShares merchandise. Past performance is just not a dependable indicator of future results. The value and worth of securities (which may trade in limited markets) of the iShares merchandise and the earnings from them could fall in addition to rise and an investor could not get well the complete quantity invested. An investor's earnings from iShares merchandise isn't essentially fixed and will fluctuate. Where an investor invests in an iShares product denominated in a foreign money apart from that of the nation during which the investor is resident, the return to the investor may increase or lower as a result of currency fluctuations.
However latest data indicate that the trade's fortunes might have started to get better. For example, a research published … Read More


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Paul Krugman: The Wrong Worries
Now would be a good time for policymakers to finally get serious about job creation:
The Wrong Worries, by Paul Krugman, Commentary, NY Times: In case you had any doubts, Thursday's more than 500-point plunge in the Dow Jones industrial average and the drop in interest rates to near-record lows confirmed it: The economy isn't recovering, and Washington has been worrying about the wrong things. ...
For two years, officials at the Federal Reserve, international organizations and, sad to say, within the Obama administration have insisted that the economy was on the mend. Every setback was attributed to temporary factors — It's the Greeks! It's the tsunami! — that would soon fade away. And the focus of policy turned from jobs and growth to the supposedly urgent issue of deficit reduction.
But the economy wasn't on the mend. ... Where was growth supposed to come from? Consumers, still burdened by the debt that they ran up during the housing bubble, aren't ready to spend. Businesses see no reason to expand given the lack of consumer demand. And thanks to that deficit obsession, government, which could and should be supporting the economy..., has been pulling back.
Now it looks as if it's all about to get even worse. So what's the response?
To turn this disaster around, a lot of people are going to have to admit, to themselves at least, that they've been wrong and need to change their priorities, right away. ... Those plunging interest rates and stock prices say that the markets aren't worried about either U.S. solvency or inflation. They're worried about U.S. lack of growth. And they're right...
Earlier this week, the word was that the Obama administration would "pivot" to jobs now that the debt ceiling has been raised. But what that pivot would mean, as far as I can tell, was proposing some minor measures that would be more symbolic than substantive. And, at this point, that kind of proposal would just make President Obama look ridiculous.
The point is that it's now time — long past time — to get serious about the real crisis the economy faces. The Fed needs to stop making excuses, while the president needs to come up with real job-creation proposals. And if Republicans block those proposals, he needs to make a Harry Truman-style campaign against the do-nothing G.O.P.
This might or might not work. But we already know what isn't working: the economic policy of the past two years — and the millions of Americans who should have jobs, but don't.
Posted by Mark Thoma on Friday, August 5, 2011 at 12:33 AM in Budget Deficit, Economics, Politics, Unemployment |
Comments (82)


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The words 'first, tallest, deepest, most expensive, lavish, outlandish' could have been created for this city. Where else would you find a seven-star hotel, visit a series of 200 man-made islands in the shape of the countries of the world, or climb the world's tallest building?
Amidst all this modernity, as you head from a swim in the sea or a business meeting to designer boutiques, a round of golf or a top teppanyaki restaurant, the age-old souks still attract those who like to haggle. And yet only a few kilometres into the magnificent desert there are still camels roaming free.
There is a vibrant and cosmopolitan air about Dubai, for instance the way the traditional abra boats carry a kaleidoscope of tourists side by side with sari-wrapped Indians and locals sporting spotless dishdashas.
Outside of Dubai life is more traditional and moves at a slightly slower pace. As you explore the barren beauty of the mountains, or go about the UAE's East coast beaches you will find people friendly and willing to chat, even when lacking a common language.


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HEAVEN AND HELL7:40 am
Scripture for Today
2 Corinthians 9:6 The point is this: whoever sows sparingly will also reap sparingly, and whoever sows bountifully will also reap bountifully. (ESV)
A holy man was having a conversation with the Lord one day and said. "Lord, I would like to know what Heaven and Hell are like.
The Lord led the holy man to two doors.
He opened one of the doors and the holy man looked in. In the middle of the room was a large round table. In the middle of the table was a large pot of stew, which smelled delicious and made the holy man's mouth water. The people sitting around the table were thin and sickly. They appeared to be famished. They were holding spoons with very long handles that were strapped to their arms and each found it possible to reach into the pot of stew and take a spoonful.
But because the handle was longer than their arms, they could not get the spoons back into their mouths. The holy man shuddered at the sight of their misery and suffering.
The Lord said, "You have seen Hell.
They went to the next room and opened the door. It was exactly the same as the first one. There was the large round table with the large pot of stew which made the holy man's mouth water. The people were equipped with the same long-handled spoons, but here the people were well nourished and plump, laughing and talking.
The holy man said, "I don't understand."
"It is simple," said the Lord. "It requires but one skill. You see they have learned the secret to happiness..... feed one another."
The secret of happiness in life is hinged on giving. When you give you become less self centred and more concerned about others.
In our generation most of us prefer taking care of ourselves only and not caring if the other person is fine.
In most churches, we are more concerned about the church project than we are about our needy and sick members. Someone might not be necessarily poor but they need counseling, they need someone who could comfort them in their times of trials.
The body of Christ is a body that cares, that loves and gives. Let's not forget true Christianity while trying to be religious.
Make a decision to help someone in need in anyway no matter how little!
Prayer: Father, thanks so much for revealing the secret of happiness, may I walk in this victory
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Snow chains for your car that switch on and off
The days of frozen fingers hampering your efforts to fit snow chains may soon be over, as Stuart McDill reports, now you can watch them automatically deploy at the press of a button.
The easy way to fit snow chains - fast and simple. It's the brainchild of an automotive car part manufacturer - inspired by a late night struggle to fit traditional chains in freezing temperatures. The solution - a base plate fitted to the wheel at the start of winter - snow chain hubs snapping on and off when needed. The grip provided by four arms that extend out of the centre hub to grip the tyre. PETR GROSS / SNOW CHAIN DEVELOPER "The anti-sliding function is located here on the grabs and has steel spikes which are used for hard packed ice and plastic ones which are used in soft snow," Three years in development Gross now has a patent in his native Czech Republic, with others applied for abroad. PETR GROSS / SNOW CHAIN DEVELOPER "We see a future use of the chains mainly for trucks and busses because those vehicles mostly have only summer tyres and no special tyres for the winter, and the use of some anti-slips or chains is crucial for them. This device is very simple to put on and easy to handle and that's why we thing it has a great future." Gross plans to market his product in Europe, Russia, the U.S. and Canada.