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This Sunday is the day we all dread, when we lose an hour thanks to Daylight Saving Time. Who can afford to give up 60 minutes of work, play or, perhaps most importantly, sleep?
To prepare us for setting our clocks -- real and internal -- ahead, I turned to Kristin Daley, a licensed clinical psychologist at Southeast Psych in Charlotte, N.C to chat about sleep. Sleep is Daley's specialty.
The quality of stress affects slumber.
When I reached out to Daley recently, it was to tell her that in my relatively new life as an entrepreneur I'm sleeping better than ever. (Gosh, I hope I haven't jinxed things.)
Why is that? Why is it easier to sleep when we love our work and harder when we hate our job or it's stressing us out?
Daley told me about neuropsychologist, Kelly McGonigal, who gave a TED Talk on how to make stress your friend, and research that shows how the body responds to stress has to do with our perception of the cause of stress.
"If it is something we feel is our calling to do or adds meaning to our lives, our bodies will be a lot less reactive to stress. If it's your passion project, and you are thrilled to work 24/7, it will have less effect on your sleep," Daley said. "But if we feel the source of stress is outside our personal control, our body is significantly more reactive."
Put a "curfew" on your work.
But is it okay for entrepreneurs who love their work to get by on precious little sleep?
No, everyone needs good, quality sleep at some point, Daley said.
If you don't regularly get the prescribed amount of sleep -- ideally seven to nine hours -- you risk your health and your business, Daley said.
The effects of sleep deprivation on physical health are clear: suppressed immune system and dietary functions, she said. Too little sleep leads to cravings of simple carbs and less awareness of food that's been consumed, so that impacts metabolism. There's increase in overall compulsivity, which isn't good for those who have to make a lot of decisions every day.
"For entrepreneurs, sometimes the wrong decision could be catastrophic," Daley said.
She advises putting a curfew on work. No work emails past a certain time. No screens a few hours before bed. But work curfews are hard for people who who are passionate about what they do. They can become martyrs when it comes to sleep, giving up slumber to answer one more email or check one more item off the to-do list.
"I have a client who is a pretty successful entrepreneur, and his insomnia started before he started his company," Daley said. "His insomnia is almost part of his success story. It's like `I care so much that I am sacrificing sleep for it.'"
You are not Richard Branson.
What about Marissa Mayer, former CEO of Yahoo!, who said she sleeps three to four hours a night so she can work 130 hours a week?
It depends on your metabolism for sleep, Daley said. Some people are so-called short sleepers, she said, citing Virgin Group founder Richard Branson, who goes to bed at 11 p.m. and wakes up at 5 a.m.
"If your metabolism for sleep is naturally low, that's different than someone cutting their sleep to six hours," she said.
The only way you know how much sleep you need is to have times when you step away from work and relax, Daley said. It's called vacation.
Think about your accomplishments.
Daley also recommends you pat yourself on the back for your accomplishments. Take a moment to savor the highlights of every day.
We tend to move quickly from task to task, not taking time to relish our wins, she said. Our brains will focus more on fears than our victories, so we have to work extra hard to tell our brains the good stuff.
Daley advises taking a few moments each day to write down what we've done and how we will tackle tomorrow's challenges.
"If we don't have it in writing, our brains will chatter to us about it in the middle of the night," she said. "There's something about writing out a plan that gives our brains this wonderful sense of control and allows for rest."
You could also write down this date: Nov. 4.
That's when we get our hour back.


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Born in Guanajuato, Mexico, and raised in the state of Washington, Andrea Negrete is a fifth year doctoral student in Community Psychology at the University of Virginia. She is also a Ford Foundation Predoctoral Fellow. She received her bachelor's degree in psychology and master's degree in education from the University of Washington.
In June 2019, Andrea became a PhD+ intern for the Cooper Center, where she lends her project management and both quantitative and qualitative research experience to several CSR projects. She is currently working on the Cancer Center Catchment Area Survey, in which UVA Cancer Center's catchment area will be surveyed on their health practices and beliefs. She is also assisting with the Reston Community Center Survey. A bilingual researcher, Andrea will be translating the survey, as well as future projects, into Spanish.
Outside of CSR, Andrea enjoys hiking and taking her dogs on walks. She also conducts research at the Promoting Healthy Adolescent Development (PHAD) Lab at U.Va., where she has been working for the past five years. At both the Cooper Center and the PHAD Lab, she loves the applied research work and community engagement within the research process. She hopes to take on many more projects related to the promotion of healthy adolescent development in the future.
What does public service mean to you?
Engaging in work for the betterment of the community that you are a part of.

subset: commoncrawl


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I need help.
My parents are to the point of divorce and it's stressing me out as well. Because everything that I do my dad cusses up a storm to my mom and blames my mom for being a bad parent. I go to college full time job and I forget the little things like dishes in the sink and half empty soda cans. I am so close to sitting them down and having a talk with them but I'm afraid to.


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Cooking Matters for Families
Thursdays, May 21 - June 25
6 - 8 p.m.
Demonstration Kitchen at Sparrow Hospital
1215 E Michigan Ave.
Lansing MI, 48912
Cooking Matters for Families is a hands-on nutrition program. Parents/guardians with their children, ages 8 -18, learn about preparing healthy meals together, food safety, grocery shopping, and budgeting for food.
The program consists of six lessons, lasting two hours each. With the help of an experienced chef and nutrition educator, participants will gain the skills and confidence to make healthy, budget-friendly meals at home as a family. Each week, participants will receive take-home groceries, which they can use at home to practice, as a family, a recipe they learned in class.
Please plan to attend all six classes.
Cost: FREE
Registration for Attendee Registration is open.
Registration closes at 11:59 p.m. on May 19, 2020.
Michigan State University is committed to providing equal opportunity for participation in all programs, services and activities. Accommodations for persons with disabilities may be requested by contacting the event contact two weeks prior to the start of the event. Requests received after this date will be honored whenever possible.


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Course: Door Supervision
BIIAB Level 2 Award in Door Supervision
Courses are held on a regular basis at ETS. Courses can also be held at a client's premises provided advanced warning is given.
The course will cover:
- Working in the Private Security Industry
- Working as a Door Supervisor
- Conflict Management
- Physical Intervention Skills
Price £200.00
All prices quoted will be Inclusive of VAT (charged at the current rate).
If you wish to book a place on this course or require any further information please contact ETS Administration by phone on 0191 216 9572or via email and they will be happy to help.


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NEW YORK (MarketWatch) -- Emcore Corp. EMKR, -2.22% said Tuesday it acquired the analog cable TV and radio frequency over fiber specialty businesses from JDS Uniphase Corp. jdsu ca:jdu for $1.5 million. Emcore also agreed to buy between $2.8 million and $3.8 million of components and parts over the next two years for use in the manufacture of the acquired products. Emcore also will assume some open purchase orders for inventory components and pay JDS Uniphase a royalty on licensed intellectual property. Emcore expects the deal will increase fiscal 2006 revenue by $10 million to $15 million. The two companies also reached a bilateral "preferred supplier" commercial agreement under which they will supply each other with various optical components.
Emcore Corp. buys JDS Uniphase's analog CATV business
Quote References
-0.07 -2.22%


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Watch: INFINITE Tries Dancing To "BANG BANG BANG" And "Gashina" With Their Own Choreography
INFINITE appeared on the January 10 broadcast of MBC every1's "Weekly Idol" to promote their third album "Top Seed."
As soon as INFINITE stepped onto the set, they were handed the Grand Prize (Daesang) from the 7th Weekly Idol Awards that was held last year. The members accepted the award with puzzled expressions and said, "We have never received the Grand Prize before. Thank you."
INFINITE also performed their title track "Tell Me" for the first time on broadcast where they showed off their energetic dance moves and in-sync choreography. After watching their performance, the MCs praised the group and commented, "I think this song is going to stay on the charts for a long time."
On this episode, INFINITE was introduced to a new game on "Weekly Idol" called the magic choreography game, where artists try to dance their choreography to another artist's song. INFINITE was surprised by this new game and danced their "BTD" choreography to the tune of GFRIEND's "Glass Bead." The members relied on their main dancer Dongwoo, but he was the first one to get confused.
The MCs refused to give up and suggested INFINITE dance to Sunmi's "Gashina" with their choreography for "The Chaser" followed by BIGBANG's "BANG BANG BANG" using their choreography for "Be Mine."
While dancing to both songs, the members couldn't help but do Sunmi and BIGBANG's choreography in the chorus. Although they weren't successful at completing their mission, INFINITE's teamwork of nine years shined throughout the episode.
Watch INFINITE play the magic choreography game below!
Source (1)


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Sports Physical Therapy in Kenosha seeks to keep our patients, staff, and professional network informed by maintaining a blog about our industry. This includes articles from our providers, training tips, news about upcoming therapies and products, and more. Click on the titles below to read more on each topic.
Signs of Carpal Tunnel Syndrome
Carpal Tunnel is one of the most common diagnoses. What happens is the median nerve gets compromised in the wrist – usually caused by repetitive wrist motion or bending it forward too often. Signs of Carpal Tunnel include: Waking up at night from pain, numbness, and tingling in the hand Numbness in the thumb, index, middle, and half of the ring finger Painful hand cramping in the muscle Hand weakness What to do if you have these symptoms? See a hand therapist for an evaluation and to teach you how to properly do median nerve glides. This gets that entrapped nerve gliding and can reduce adhesions. Get a wrist splint. Our OT's and Hand Therapists make custom splinting for our patients at Sports Physical Therapists. Wear your splint at night and when you're doing heavy activities. A lot of times
Why Physical Therapy is About More Than 'Getting Better'
When a patient makes an appointment with a physical therapist to rehabilitate after a shoulder injury, for example, it's because he wants to get better, right? Well, yes, but what exactly does that mean? As it turns out, "getting better" means different things to different patients. To some, proper recovery from a shoulder injury means being able to carry a golf bag and swing a club while to others, it means being able to lift their children in and out of their car seats. Here's the thing: Helping your physical therapist know and understand your own personal goals is the key to success. As a patient, that means speaking up early and often about how the injury is limiting the everyday activities that are most important to you. With this knowledge, your PT can adapt her approach and individualize aspects
Welcoming Michelle Shamash, Certified Hand Therapist (CHT)
Sports Physical Therapists is thrilled to welcome Michelle Shamash to our team of experienced, dedicated therapists. Michelle works in our Fox Lake location and brings 20 years of training and patient care as a dynamic Certified Hand Therapist (CHT). Michelle graduated from University of Wisconsin-Madison in 1992 with a degree in occupational therapy. Six years later, after completing the required five years of therapy experience, she passed a rigorous exam to obtain her certification in Hand Therapy. She has been a Certified Hand Therapist ever since. During her early years as a CHT, Michelle built very strong connections to several highly regarded surgeons who practiced at Northwestern, Rush and Loyola hospital systems in downtown Chicago. She eventually opened her own therapy business in Fox Lake, IL, where she served patients for 15 years. During this time, the group of
Benefits of receiving treatment from a Certified Hand Therapist. Accurate Assessment of Injuries A Certified Hand Therapist (CHT) has the highest level of hand therapy certification for treating arm and hand injuries. We are dedicated to providing high quality care in a friendly and encouraging environment. We take pride in the level of personal and compassionate care that is delivered; emphasizing a "hands-on" approach to rehabilitation and exercise. We perform comprehensive evaluations and encourage patient input for treatment planning and goal-setting. Our personalized approach ensures patient cooperation and understanding that enhances proper treatment progression to achieve the best outcomes for our patients. Non-Invasive, Conservative Treatment Plans CHTs provide movement-based therapeutic solutions. Many people looking for the most conservative, least-invasive treatment plan possible will find great success with a CHT. If you want to explore every possible avenue before going the surgical
7 ways to exercise on a busy schedule
Are you ready to hit 2019 running? The hustle and bustle of the holiday season may be over, but many of you are still very busy with your everyday schedule. Here are 7 simple tips to help you stick to your New Year's Resolution. 1) Integrate exercise. It's much easier to accommodate if you find ways to incorporate activity into your daily routine. Climbing the stairs to the third floor instead of waiting for the elevator, or parking further away to get more steps in. 2) Take a fitness class. Instead of roaming the gym looking for a machine, get together with a workout buddy and join a fitness class. 3) Clean more often. Make your household chores into a workout session by incorporating ankle weights or squats. 4) Wake up earlier. Morning workouts will boost your metabolism and have
Injury Prevention: What Is It?
Zach Koba, MS, CSCS Injury Prevention: What is it? Most of my current and former clients have the same goal- to be able to perform activity without pain. Overall, to summarize injury prevention in its simplest form, prevention is nothing more than systematically progressing your bodies tissue tolerances gradually to be able to perform the exercise or sport specific functions of your choosing with the least chance of injury. Clinically this may mean that we are working on your "tissue tolerance" to activity while a strength and conditioning coach may refer to the same concept as periodization of a training program. Let's think about this from a strength and conditioning standpoint. Many of my clients come to me after the insult or injury has already happened. Whenever I evaluate a new client everything starts with an assessment. If we don't
What is a Physical Therapist?
When we overstep our abilities to heal, when we ignore the warning signs our bodies are desperately sending us, when we do not allow the appropriate time our bodies need to recover we create injury. What is a Physical Therapist? By Joe Ford PT, DPT, FAAOMPT, OCS The human body is in a constant state of change. Whether this is breaking down old tissue or building new tissue we are built to repair, renew, and rejuvenate. The way in which this happens is known as the SAID (Specific Adaptation to Imposed Demands) principle. Stress on the body can do two things; stimulate it to grow stronger and be more resilient, or, when too chronic or too high an initial dose, break us down past our healing capabilities and create an injury. The ability to heal from any stress is dependent
Plantar Fasciitis – Symptoms and Treatment
Who am I? First, I'd like to introduce myself – I'm Mike Leitza. I'm a Licensed Physical Therapist with 20 years of experience treating outpatient orthopedics (injuries to muscles, tendons, ligaments, and bones). I had the idea to start a blog to provide you with some helpful information about common injuries we see on a regular basis in the office. This may include basic information about the soft tissues (e.g. tendons, muscles, ligaments), bones involved with injuries, possible ways you can help yourself at home prior to seeking professional medical advice (e.g. appointment with physician or physical therapist), and advice on when and why it would be beneficial to seek medical attention. Today's topic - plantar fasciitis! Plantar Fasciitis: Do you dread getting out of bed in the morning or standing up after extended sitting due to severe pain on the
Treatments for Tennis Elbow
My name is Mike Leitza and I am a licensed physical therapist with 20 years experience treating in outpatient orthopaedics. I am starting this blog to give the consumer some general information about common injuries we see in physical therapy including; basic information about the soft tissues (tendons, muscles, ligaments) or bones involved with these injuries, some possible ways the consumer can help themselves out at home prior to seeking professional medical advice (appointment with physician or physical therapist), and some advice on when/why it would be beneficial to seek medical attention. Tennis Elbow/Lateral Epicondylitis Do you have a nagging/persistent pain on the outside part of your elbow that seems to be aggravated with use of your hand and resisted gripping/lifting. If you do then you may have tennis elbow. The proper medical term is lateral epicondylitis. Even though
6 Balance Exercises You Can Safely Perform at Home
Dangerous falls are increasingly common in people over 65 years of age and can result in serious injury, and even death. According to the Centers for Disease Control and Prevention, 2.5 million older people are treated in the emergency room for fall injuries each year. The average health care costs related to falls is $35,000 per fall. Performing safe exercises at home can help strengthen your lower body to reduce your overall fall risk. The following are 5 easy exercises that you can do at home. Always check with us before beginning any home-exercise program. For all of the following exercises, position yourself near a counter top or sturdy surface that you can hold on to for support. 1. Standing March Stand in place and start marching in place slowly for 20-30 seconds. As this becomes easier, challenge your balance


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The STM32L552xx devices are an ultra-low-power microcontrollers family (STM32L5 Series) based on the high-performance Arm® Cortex®-M33 32-bit RISC core. They operate at a frequency of up to 110 MHz.
The Cortex-M33 core features a single-precision floating-point unit (FPU), which supports all the Arm® single-precision data-processing instructions and all the data types. The Cortex-M33 core also implements a full set of DSP (digital signal processing) instructions and a memory protection unit (MPU) which enhances the application's security.
These devices embed high-speed memories (512 Kbytes of Flash memory and 256 Kbytes of SRAM), a flexible external memory controller (FSMC) for static memories (for devices with packages of 100 pins and more), an OctoSPI Flash memories interface (available on all packages) and an extensive range of enhanced I/Os and peripherals connected to two APB buses, two AHB buses and a 32-bit multi-AHB bus matrix.
The STM32L5 Series devices offer security foundation compliant with the trusted based security architecture (TBSA) requirements form Arm. They embed the necessary security features to implement a secure boot, secure data storage, secure firmware installation and secure firmware upgrade. Flexible life cycle is managed thanks to multiple levels of readout protection. Firmware hardware isolation is supported thanks to securable peripherals, memories and I/Os, and also to the possibility to configure the peripherals and memories as "privilege".
The STM32L552xx devices embed several protection mechanisms for embedded Flash memory and SRAM: readout protection, write protection, secure and hidden protection areas.
The STM32L552xx devices embed peripherals reinforcing security:
- One HASH hardware accelerator
- One true random number generator
The STM32L5 Series devices offer active tamper detection and protection against transient and environmental perturbation attacks thanks to several internal monitoring which generate secret data erase in case of attack. This helps to fit the PCI requirements for point of sales applications. These devices offer two fast 12-bit ADC (5 Msps), two comparators, two operational amplifiers, two DAC channels, an internal voltage reference buffer, a low-power RTC, two general-purpose 32-bit timer, two 16-bit PWM timers dedicated to motor control, seven general-purpose 16-bit timers, and two 16-bit low-power timers. The devices support four digital filters for external sigma delta modulators (DFSDM). In addition, up to 22 capacitive sensing channels are available.
STM32L5 Series also feature standard and advanced communication interfaces such as:
- Four I2Cs
- Three SPIs
- Three USARTs, two UARTs and one low-power UART
- Two SAIs
- One SDMMC
- One FDCAN
- USB device FS
- USB Type-C / USB power delivery controller
The devices operate in the -40 to +85 °C (+105 °C junction) and -40 to +125 °C (+130 °C junction) temperature ranges from a 1.71 to 3.6 V power supply. A comprehensive set of power-saving modes allows the design of low-power applications.
Some independent power supplies are supported like an analog independent supply input for ADC, DAC, OPAMPs and comparators, a 3.3 V dedicated supply input for USB and up to 14 I/Os, which can be supplied independently down to 1.08 V. A VBAT input allows to backup the RTC and backup the registers.
The STM32L552xx devices offer seven packages from 48-pin to 144-pin.
Key Features
- Ultra-low-power with FlexPowerControl
- 1.71 V to 3.6 V power supply
- -40 °C to 85/125 °C temperature range
- Batch acquisition mode (BAM)
- 320 nA in VBAT mode: supply for RTC and 32x32-bit backup registers
- 17 nA Shutdown mode (5 wakeup pins)
- 68 nA Standby mode (5 wakeup pins)
- 391 nA Standby mode with RTC
- 4 μA Stop 2 with RTC
- 106 μA/MHz Run mode (LDO mode)
- 62 μA/MHz Run mode @ 3 V (SMPS step down converter mode)
- 5 µs wakeup from Stop mode
- Brownout reset (BOR) in all modes except shutdown
- Core
- Arm® 32-bit Cortex®-M33 CPU with TrustZone® and FPU
- ART Accelerator™
- 8 Kbytes instruction cache allowing 0-wait-state execution from Flash memory and external memories; frequency up to 110 MHz, MPU, 165 DMIPS and DSP instructions
- Performance benckmark
- 1.5 DMIPS/MHz (Drystone 2.1)
- 442 Coremark® (4.02 Coremark®/MHz)
- Energy benchmark
- 370 ULPMark-CP® score
- 54 ULPMark-PP® score
- 27400 SecureMark-TLS® score
- Memories
- Up to 512 Kbytes Flash, two banks read-while-write
- 256 Kbytes of SRAM including 64 Kbytes with hardware parity check
- External memory interface supporting SRAM, PSRAM, NOR, NAND and FRAM memories
- OCTOSPI memory interface
- Security
- Arm® TrustZone® and securable I/Os, memories and peripherals
- Flexible life cycle scheme with RDP (readout protection)
- Root of trust thanks to unique boot entry and hide protection area (HDP)
- SFI (secure firmware installation) thanks to embedded RSS (root secure services)
- Secure firmware upgrade support with TF-M
- HASH hardware accelerator
- Active tamper and protection against temperature, voltage and frequency attacks
- True random number generator NIST SP800-90B compliant
- 96-bit unique ID
- General-purpose input/outputs
- Up to 114 fast I/Os with interrupt capability most 5 V-tolerant and up to 14 I/Os with independent supply down to 1.08 V
- Power management
- Embedded regulator (LDO) with three configurable range output to supply the digital circuitry
- SMPS step down converter
- External SMPS support
- Clock management
- 4 to 48 MHz crystal oscillator
- 32 kHz crystal oscillator for RTC (LSE)
- Internal 16 MHz factory-trimmed RC (±1%)
- Internal low-power 32 kHz RC (±5%)
- Internal multispeed 100 kHz to 48 MHz oscillator, auto-trimmed by LSE (better than ±0.25% accuracy)
- Internal 48 MHz with clock recovery
- 3 PLLs for system clock, USB, audio, ADC
- Up to 16 timers and 2 watchdogs
- 16x timers: 2 x 16-bit advanced motor-control, 2 x 32-bit and 5 x 16-bit general purpose, 2x 16-bit basic, 3x low-power 16-bit timers (available in Stop mode), 2x watchdogs, 2x SysTick timer
- RTC with HW calendar, alarms and calibration
- Up to 19 communication peripherals
- 1x USB Type-C™/ USB power delivery controller
- 1x USB 2.0 full-speed crystal less solution, LPM and BCD
- 2x SAIs (serial audio interface)
- 4x I2C FM+(1 Mbit/s), SMBus/PMBus
- 6x USARTs (ISO 7816, LIN, IrDA, modem)
- 3x SPIs (7x SPIs with USART and OCTOSPI in SPI mode)
- 1x FDCAN controller
- 1x SDMMC interface
- 2 DMA controller
- 14 DMA channels
- Up to 22 capacitive sensing channels:
- Support touch key, linear and rotary touch sensors
- Rich analog peripherals (independent supply)
- 2x 12-bit ADC 5 Msps, up to 16-bit with hardware oversampling, 200 µA/Msps
- 2x 12-bit DAC, low-power sample and hold
- 2x operational amplifiers with built-in PGA
- 2x ultra-low-power comparators
- 4x digital filters for sigma delta modulator
- CRC calculation unit
- Debug
- Development support: serial wire debug (SWD), JTAG, Embedded Trace Macrocell (ETM)
- Ultra-low-power with FlexPowerControl
Circuit Diagram
Sample & Buy
|Part Number
|Packing Type
|Temperature (°C)
|Marketing Status
|Budgetary Price (US$)*
|Country of Origin
|More info
|Order from Distributors
|Order from ST
|LQFP 64 10x10x1.4
|No availability of distributors reported, please contact our sales office
PackageLQFP 64 10x10x1.4
Packing TypeTray
Unit Price (US$)2.9487*
Operating Temperature (°C)
Marketing Status
Unit Price (US$)
Country of Origin
(*) Suggested Resale Price per unit (USD) for BUDGETARY USE ONLY. For quotes, prices in local currency, please contact your local ST Sales Office or our Distributors
Featured Videos
MadeForSTM32™ is a new quality label delivered by ST, which is granted after an evaluation process. It helps engineers identify third party solutions with the highest level of integration and quality for the STM32 microcontrollers' ecosystem. MadeForSTM32™ is offered to members of the ST Partner Program who want to go one step further in our collaboration, with the overall objective of contributing to a high-quality STM32 ecosystem.
The STM32Cube.AI is an extension pack of the widely used STM32CubeMX configuration and code generation tool enabling AI on STM32 Arm® Cortex®-M-based microcontrollers.
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|Part Number
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|RoHS Compliance Grade
|Material Declaration**
|LQFP 64 10x10x1.4
Package:LQFP 64 10x10x1.4
Material Declaration**:
Marketing Status
LQFP 64 10x10x1.4
(**) The Material Declaration forms available on st.com may be generic documents based on the most commonly used package within a package family. For this reason, they may not be 100% accurate for a specific device. Please contact our sales support for information on specific devices.


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Should Homeowners and Renters Have a Personal Insurance Policy?
Personal property includes the things a person owns, such as electronics, clothing, jewelry, and furniture. Whether one owns a home or rents an apartment, an insurance policy usually includes personal coverage. Below are several things to consider when protecting a house full of belongings with a Personal Insurance Policy.
How Much Coverage is Available?
There are two kinds of personal property insurance: those that cover the item's replacement cost and those that pay actual cash value. It's important for policyholders to know that personal property insurance usually has limits on what the policy will pay to replace certain items or categories of items.
What's Covered by Renters' Insurance?
Many renters believe that a landlord's insurance policy covers their belongings after a loss. While the landlord's insurance protects the structure from certain perils, the coverage doesn't extend to the renter's belongings. Renters' insurance can protect a person's possessions up to the policy's coverage limit.
Homeowner's Insurance Coverage
Along with providing liability and dwelling protection, many homeowner's insurance policies include personal property coverage up to the policy limit. If a home is damaged by a named peril, the insurer helps cover lost belongings. Coverage is subject to the policy's limits and terms, and it's important for policyholders to carefully read the policy documents or ask an agent if they need clarification.
Lost Items
Most renters' and homeowners' policies don't offer lost item coverage. If a valuable item is stolen, insurance will likely cover it. However, if it's left behind or lost, it likely won't be covered. Scheduled personal property insurance can be bought for specific items; an agent can provide more specific details.
Scheduled Property
While a customer may find that a renters' or homeowners' policy offers protection for their belongings, the coverage often comes with limits for certain property types and items. An insurance agent can help a customer determine whether they should schedule certain items, or buy separate coverage for the additional protection of valuable items like musical instruments, art, or jewelry.
While homeowners' and renters' insurance policies offer valuable protection, in some cases, it may not be enough. For additional information or to buy a Personal Insurance Policy, visit us at schlatherinsurance.com.


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Site History
What's New?
Site-specific Standard
5 Year Review Status
No Further Action
Northwest Neighborhood
Environmental Oversight
Community Involvement
Contact Us
Community Involvement
Lowry Restoration Advisory Board (RAB) Formally Adjourned
In accordance with 32 C.F.R. §202.10, Restoration Advisory Board (RAB) Adjournment and Dissolution, the former Lowry Air Force Base (Lowry) RAB was formally adjourned in 2009. The basis for the adjournment and details of the adjournment process are described in detail in the
RAB Adjournment Memorandum .
The Lowry RAB was started in 1994 as the primary mechanism to involve the public throughout the environmental restoration process. The RAB
community members provided input to the decision-makers on restoration issues, and the RAB forum allowed the expression and careful consideration of diverse points of view. The
RAB held monthly meetings from 1994 until 2007 when RAB attendance dropped below a functioning level.
With the cessation of the RAB meetings and its formal adjournment, LAC provides ongoing public involvement in the cleanup program through this website, dedicated to the environmental cleanup program, continued production of environmental fact sheets when appropriate, and implementation of the updated
Community Involvement Plan (CIP
, dated November 2013.
The overall goal of the CIP is to promote continued communication and involvement between LAC and interested community members. As part of this goal, LAC provides periodic updates to this website as well as prepares an annual status report on the current cleanup program at Lowry. The
2016 Annual Status Report
is available. If you are interested in receiving future annual status reports, and when available, new fact sheets, please contact us at
Create a website
at CityMax.com


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SIP to continue or NOT
Mr.vikas wrote :
Hi there
Got your contact on Good fund Advisor and need your views on my investment thru SIP as below
1. SBI Contra --10000
2. Reliance Growth --10000
4. Reliance Diversified --3000
I have been in this investment since September 08.Would it be advisable to continue with the SIP or withdraw to avoid further losses.The funds overall have lost almost 35-40%.
I am told by various colleagues that we must stop (without encashing) and invest money in a Fixed Deposit.
I do not have a problem of waiting for 2-3 years but need to get a professional guidance on which is a better option to move ahead
Vikas Milhoutra
SRIKANTH SHANKAR MATRUBAI advised :
Dear Vikas,
True, you have lost money, but you are not alone, whoever has invested has lost in the Bear market. Your funds seem to be good and there is no reason why you should not continue with the same. You have not given as which fund in UTI, your sip is going. It would have made my job easier.
With your horizon of 2-3 years, these funds should give you returns MORE than Fixed Deposits. Whoever advised you to stop this Sips and invest in FDs need a lesson on how Inflation and Taxes eat away your FD returns. You are better off investing in Mutual Funds through SIPs.
You do have good set of funds (I am counting only 3, as I do not know which UTI fund you have invested in), however, you do need to have a Good Solid Large Cap Fund to compliment your existing portfolio. For this, you can look at
Birla Sunlife Frontline Equity fund
DSP Blackrock Top 100 Fund
HDFC Top 200 fund
Sundaram Select Focus Fund
among others.
Either you add another 10000 monthly to any of the above funds, or reduce your existing sip from 10000 to 5000 in both SBI Contra and Reliance Growth and invest the saved 10000 in the above fund.
Best of luck,
Srikanth Shankar Matrubai
Also visit http://equityadvise.blogspot.com for an indepth Equity Analysis
GOODFUNDSADVISOR has been in Equities for more than 28 years now. That rich experience is shown here in his insightful articles. However, we strongly suggest you to consult a Financial adviser. This blog is purely for information purposes only and we do not take any responsibility whatsoever as the blog content may be changed from time to time and is generic in nature.
Monday, March 16, 2009
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There is a huge bombardment of articles, posts, trolls on Mukesh Ambani's daughter. Its his money folks and he has every right to...


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Funny Status Message #30501
X Man vs. Wild = MAN WINS!!.....Man vs. Discovery Channel = The Police Win!! I can't wait to watch the Discovery Channel Special of the Hostage Crisis on the Discovery Channel.
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- # 55153 I watch so much of the Investigation Discovery channel, I can kill you and make it look like the Easter Bunny did it.
- # 159381 In the wild of Alaska, large packs of Discovery Channel cameramen can be spotted drinking from the lakes that thaw out in the summer months.
- # 135525 I've started watching those crime shows on the Investigation Discovery channel and I'm really getting into it. But I don't watch them for entertainment. I watch them to get new ideas.
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Please note: Not all phones are exactly the same. Not every bullet will apply to your phone.
- The model number can be found on the front cover of the Owner's Manual
- The model number can also be found in the battery compartment of the handset
- The model number will be underneath the battery on the actual handset.
- The model number can also be found underneath the bottom of the main base (it is the smallest number)
- The model number always begins with a series of Letters then numbers (older models)
- The 2011 and 2012 model number begins with a single letter "D" then a series of numbers
- The customer seems to always give the serial number because it's the largest number underneath the base.
- For the older models the model number can sometimes be found on the white stick above or below the serial number.
- For the newer models it will be on a gray strip underneath the white sticker or engraved into the actual phone. Usually black on black.


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Home Buying Companies North Atlanta, GA
Sell Your Home in North Atlanta, Georgia
So, when it comes time to get an auto loan, even if a person is now in a financially stable setting, they still have to seek auto financing for inadequate credit. As a matter of fact, greater than 1.7 million consumers have actually made an application for vehicle funding via Car Credit rating Express in simply the last 2 years. If this explains your circumstance, you'll more than happy to understand that we could aid you obtain approved for a lending to acquire a cars and truck equally as we have many others in the last 15 years.
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As well as make certain its a true preapproval and also not simply a prequalification, Da Silva says. Some lending institutions will certainly inform you that you prequalify for the funding based upon the revenue and credit history information you have actually offered. Thats not good enough for most vendors today.
Getting A Home Mortgage After Personal bankruptcy Your credit history is still an aspect, yet considering that a specific financier has much higher freedom in exactly how it is to be evaluated these financings are typically quicker offered for people with poor credit report. Borrowing criteria are considerably much more lax as well as rate of interest are normally less than those provided by traditional lenders. In addition, peer-to-peer websites assist review risk for the lending institution, while validating the lenders credentials for the customer.
We Buy Ugly Home in North Atlanta
What To Offer On A Residence Price Competition The number of energetic homes are currently on the market? The amount of satisfy your search criteria? Check out your CMA and also see the amount of active comparables there are. Great deals of houses suggest lots of supply, an indication of a purchaser's market. Obviously, the number of homes that constitutes "a great deal" in any type of area is relative to the historical norm, so you might need to ask for your Realtor's knowledgeable opinion about whether the current supply of homes on the market is scarce or numerous as compared to North Atlanta.
Standard home loans-- that is, those not guaranteed by the federal government and that comply with Fannie Mae or Freddie Mac's lending standards-- were fairly tough to obtain in the wake of the monetary situation. This was specifically real if you really did not have 20% of the residence's purchase rate to take down.
Sell My Home Quick in North Atlanta
Making A Deal On A Residence Canada Purchaser's Market versus Seller's Market Whether your area is currently in a customer's market or a seller's market can have a terrific effect on the price and also other terms you provide. How can you tell whether your home remains in a buyer's market or a seller's market? The short response you'll recognize. Realty currently rivals weight-loss, Brangelina, as well as Suri Cruise ship as an obsession for Americans, and you'll listen to everyone around you from neighborhood and also nationwide pundits and also reporters to the watercooler crowd as well as your publication club buddies telling tales of their real estate experiences. Though this is a unscientific and also extremely unscientific technique of market analysis, listening to several people spin comparable tales can properly suggest the instructions in which the market is leaning. For example:
"Being a home owner often has surprises, like a ruptured pipeline in the center of the night that has to be fixed right away," Gilmour states. "So you should be economically all set for these shocks, which implies you shouldn't diminish your reserve for expenditures like furnishings or remodeling."
Buyers Of Houses in North Atlanta
Property Investors Plc North Atlanta Realty Investors Association (JaxREIA) http://www.jaxreia.com/ Call: Admin [email protected] Telephone: (904) 448-4467 When: 1st Thursday of every month, 6:00 pm (5:30 pm new membership alignment) Where: Schultz Center, 4019 Boulevard Center Dr., North Atlanta
After you locate a property online, its a great idea to own by the building to obtain a much better suggestion of the residential or commercial properties problem and the kind of neighborhood. For some customers as well as investors, owning by the building has also assisted in a casual meeting with the proprietor (you could be able to still exercise a last-minute bargain before the auction) or produced a wealth of unforeseen info from a talkative next-door neighbor.
Sell Your House Fast in North Atlanta
Getting A Residence At Auction A good rule of thumb for Georgia residence customers who are aiming to estimate exactly what their property taxes will certainly be is purchase cost x 1.25%. This incorporates the base rate of 1% as well as added local taxes, which are typically about 0.25%.
Making A Deal On A House Qld The CMA report your Real estate agent prepares will certainly note the status and also specs of each of the comparable residential properties (comps), the list price, the list prices, as well as the variety of days the building got on the marketplace (DOM), and also will probably also give some estimations such as low and high prices, typical prices, and also price each square foot ($/ ft2).
Cost Of Selling House North Atlanta Georgia
Episode Resources ZipRecruiter The Global Realty Top REIN Rich Father Poor Father by Robert Kiyosaki EP191: How You Can Take Advantage Of Debt to Construct Wide Range - Meeting with Robert Kiyosaki Sign Up For Investing in Realty on iTunes Locate Your Financial Flexibility Number Sign Up For the Morris Invest YouTube network Like Morris Invest on Facebook Get In Touch With Thembi Bheka Website Facebook Twitter LinkedIn
As an example, if you can consent to develop your housing examination swiftly and to take obligation for smaller sized fixings that arise your deal will definitely be a lot a lot more captivating as compared to a completing offer that consists of a lot more pre-closing repair work to be finished by the seller.
House Seller North Atlanta Georgia
Obtaining A Home Mortgage With Bad Credit scores The types of improvements covered by your finance will vary by type, however the HomeStyle loan is a lot more lenient, and also will usually enable any remodel that stays a permanent part of the home and also adds precise value. The 203( k) does not permit anything thought about to be a frivolous upgrade, like including a swimming pool, yet might permit wall surface relocation or including square footage.
Selling A Home As Is North Atlanta Georgia
Tennessee Home Buyers in North Atlanta
Other articles that may be of interest to you:
- real e in North Atlanta, GA
- sell house fast in North Atlanta, GA
- who buys houses for cash in North Atlanta, GA
- fast cash for house in North Atlanta, GA
- who buys ugly houses in North Atlanta, GA


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THE Philippine celebration of the National Arts Month this year further sizzles with the kick off of the 2018 Fringe Festival which runs until Feb. 25.
Fringe Festival organizers said from Feb. 7 to 25, the 2018 Fringe Festival celebrates the Philippine Arts Month by featuring several of the "most dynamic interdisciplinary performances and groundbreaking new works in contemporary arts."
For its 4th year, the festival is presented by Pineapple Lab, a Poblacion, Makati City-based creative hub dedicated to finding innovative ways to present the works of Filipino art-makers, international artists, and collaborators.
"Fringe's mission is to make art accessible to audiences here in Manila who want to engage with the arts through fresh lenses and experience works that resonate with them. We built this festival as an inclusive platform for artists here in the Philippines, Fil–X artists (i.e. Filipino-Canadian, Filipino-American, Filipino-European, etc.), and international creatives to present original works that celebrate the diversity of talent that converge in the Metro," Andrei Nikolai Pamintuan, Fringe Manila's founding board member and festival director, said.
This 2018, festival-goers can expect the comeback of Fringe favorites such as Deus Sex Machina, SPIT, ADHD Productions, Burlesque PH, Airdance, and more fresh, exciting local and international artists coming together for one reason – to celebrate the arts.
Fringe is thrilled to showcase newcomers to the festival.
San Diego International Fringe Festival's "Artists' Pick" and "Outstanding Comedy" awardee Theatre Group GUMBO from Japan, with their show "Are you lovin it?" A surreal romp with dancing Japanese businessman, crazy cartoon mascots, and fast food satire, GUMBO brings their gut-busting, award-winning, hilarious sense of humor to Manila. "Karera", PUP Maharlika's first dance theatre production.
With choreography by Daloy Dance Company's Buboy Raquitico and costume design by Daloy and Maharlika's very own Jomari Cruz, "Karera" is inspired by the urban rat race and is an expression of the proverbial survival of the fittest in society.
Also new to Fringe is Phi Palmos, presenting Eljay Castro Deldoc's "Nobenta Nostalgia," an unfinished live documentation about the 90s TV we dearly love and fondly miss told through interviews, monologues, and songs.
Fringe will stage the championship round of the long-running live-painting competition, Art Battle, where painters battle it out for audience votes and the chance to compete in Art Battle International.
Following Art Battle are performances from Kulintronica, a California-based musician who fuses the sounds of the traditional Philippine kulintang with modern electronic music, and "Pagbalik", another California-based act performing a sound and dance narrative that reflects on the meaning of being a Filipino-American, along with the memories, history, and beliefs that the two wordsembody.
Fringe highlights the variety and volume of workshops available to audiences at this year's festival. Award-winning, Filipino-British alternative cabaret performer Sam Reynolds will be introducing workshops and performances aimed at assisting artists in developing their own cabaret pieces through the support of the British Council and Arts Council England.
Among the roster of workshops are those being held by Filipino-Canadian yoga instructor and Lululemon Athletica ambassador Kaye Peñaflor at Beyond – Rockwell, focusing on techniques involving Philippine folk dance, partner yoga, and aerial yoga.
Fringe also welcomes Andreas Vierziger, with the support of the Austrian Embassy in Manila, who is conducting a series of workshops to help develop awareness of contact points between music and various disciplines or industries (such as different musical genres, crossover, dance, visual arts, tech, and coding).
Jodinand Aguillon, the festival's creative producer and Fringe artist himself said "it's so important for these types of festivals to exist."
"By bridging independent creatives with small businesses and working with cultural institutions – Fringe works closely with its communities to make the arts a vehicle for meaningful collaborations, and a safe space for ideas and expanding networks," Aguillon said.
The 2018 team has worked closely with creative hubs contributing to the culturally dynamic character of Barangay Poblacion and the City of Makati.
Among these venues are Commune, Dulo, Kapwa, The Social, and Humble Heron, as well as Century City Mall, Beyond Rockwell, NEST, Yuchengco Museum, Alliance Française Manille, Lokal Hostel, 20:20, Green Sun, and Power Mac Center Spotlight Theatre.
Included as well are satellite venues at the Philippine Educational Theatre Association (PETA) and The PARC Foundation.
Under the umbrella of the internationally-acclaimed World Fringe Network, Fringe Manila is an open access, artist-driven community celebration that showcases "fresh, daring, and groundbreaking works" by emerging and established artists from the Philippines, as well as, international participants in theater, music, dance, visual art, film, cabaret, performance art, burlesque, spoken word, comedy, magic, workshops, and every other artistic genre in between, organizers said.
Since its inaugural run in 2015, Fringe has hosted over 30,000 audiences in 45 venues, featuring more than 500 performances and exhibits of more than 1,000 artists across numerous venues all over Metro Manila.
A collaborative effort, Fringe highlights the emerging art scene in Manila's artistic landscape.
Tickets are available at TicketWorld (891-9999) or at www.ticketworld.com.ph for some performances.
For more details and updates, visit their Facebook page at facebook.com/FringeMNL or follow them on Twitter and Instagram at @fringemnl or visit fringemanila.com


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June 28, 2019 - 3:03pm
what is the difference between retarding in bulk or balls
Is there a big difference between retarding pizza dough in bulk then divide and shape the next day, and between retarding shaped loaves ?
I'm asking because I don't have enough fridge space, so I thought why not mix then retard, and the next day I S&F , bulk ferment in RT then shape and proof in trays?
What are the differences in terms of taste profile and oven rise ?


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This campground is our home away from home in the summer! It is beautiful & very relaxing especially during the weekdays when it's not as full. The bathrooms are clean & the rangers keep up with mowing & other chores to keep the grounds clean. When it gets crowded the wifi doesn't work great & some of the campers are not very respectful; they cut through lots & don't abide by the rules (no pets on beach & no bikes or skateboards on boardwalk). The rangers get after them when they see it. Gets frustrating because it ruins it for others who care about the park. The only other downfall is there isn't much beach because of the high water table. I wish they could dredge & bring in more sand. Otherwise it's our favorite place to be!
Awesome campground! Very friendly staff. Super clean and updated bathrooms. On the kal-haven trail. All spots are pull through. And all spots are close to the bathrooms.
We go here once a summer for the past 30-ish years. I love the rocky beaches, and the beach combing is the best. We have found may different color of beach glass along with fossils and many unknown oddities. The campground is clean and the campsites are large and shady. It's a bit of a hike from the campground to the beach, but if it's too long for you driving is an option. Many restaurants in nearby South Haven along with a maritime museum and tall ship rides. Weekends fill up fast, but you'll want to spend more than two days anyway!
Playground was not suitable for toddlers (1-3 year olds). This park is best known for their hiking and biking trails which our kiddos are still a little young for. The sites are decently sized and secluded.
Very family friendly park great cost and a great area with lots of kids activitys
Campground Review:
After finding our original campground full, we were directed over to Fort Custer. We found a campsite that was large with vegetation separating us from neighbors. I didn't expect to find something this interesting as an alternate to original plans but it worked out nicely.
There are a couple hundred sites and most of them were full. Our site was on the far end of a loop. This meant a longer walk to the restrooms and showers. On the other hand, we were right across from an access trail to the blue hiking trail. Each site has a picnic table and fire pit. It was overcast upon arrival only to have the sun shine down the next day. We soon found out that there was enough clearing in the treetops to give our camp full sun for most of the day. If you camp here, I suggest one of the other sites that would give you a break from the sunny heat.
We hiked on a multi-use trail that the ranger suggested. The blue trail goes around a couple lakes and was wonderful. We did miss a sign or two and ended up turning our 4 mile trip into a 6.5 mile one but there are plenty of spots to rest and enjoy the time. We passed other hikers and bikers and even some people trying their luck at fishing. There are quite a few mountain bike trails on the other side of the recreation area. A horse trail circles around the outside edge.
Product Review:
As a Dyrt Ranger I sometimes get products to evaluate. This trip I tested out the Midland X-Talker two way radio - T77VP5. The kit we used came bundled into a zippered case that is perfect for keeping everything organized. We charged it up before our trip and even tried it out in a school building.
We read reviews that said it might not work well in buildings and thought we should see. I gave them to two high schoolers and asked them to run throughout the place testing them as they went. They came back happy and excited and wanted to keep using them.
The real test came out in the woods. The belt clip snaps on easily and this stayed connected to my pack strap for our entire hike. The X-Talker fits nicely in the hand and the buttons are perfectly placed. Another feature I wanted to try was the weather radio. It scans channels automatically to find a weather channel in range. You just need to listen to the report as it cycles through the days. We had some rain and storms moving in so this proved useful in helping us sneak out of camp really early to avoid the downpour that was looming.
The Midland X-Talker T77VP5 radios worked wonderfully and will certainly see more use on future adventures.
It was only $2 to enter the park. There was three hiking trails to choose from, we choose the "turkey trail". The trail was well marked but got quite confusing about 3/4 in. Tons of fun things to see here, beautiful stone bridges. Trail was well maintained.
We did not camp here but camp sites were very spread out and most very shaded.
Sites have electrical service only. Must use the dump station.
Cant give it any stars. Sucks that I had to. They done deserve 1 star. They have very strict rules. 5mph.. If you go over the lady screams at you and evicts you. She did that to 2 people while we were there. Stop at stop signs.. No problem. And no glass bottles..ok.. We were there because we were working in the area. Once all jobs were done on Sunday we went bank to the campground to shower and get ready for dinner.( mind you, between work and all we were hardly at the campground). Not thinking twice my husband pulled a bottle if beer out of the cooler that we brought from home Friday. He drank about 3/4 of it and the lady came up on her golf cart. Yelled at him about the glass bottle. ( we completely forgot) he went to drink the last of it and she snatched it outta his hand. She asked us "What kind of people are ".. We said. We are so sorry. We forgot. She said when are you checking out. Told her the next day. She walked away. We left for dinner. While waiting for a table, her husband called us and told us to get out.over 1 bottle of beer. She is crazy. They have morning for kids to do. No pool. No lake. Crappy playground. I'll never go there again.
Sandwiched between the highway and a parallel road, there's not much room for privacy or quiet. I've hear there's moderate fishing in the lake and plenty of shade though.
Older campground that was converted to an Outdoor Adventures property. The Activity Pavilion always had stuff for the kids to do plus there was free mini golf and a $5 go cart track.
My husband's family has been visiting this campground for 34 years and it hasn't lost its luster! The beach has shortened QUITE A BIT, but it's still a great campground and park.
Nice campground overlooking Ellsworth lake. Lot are decent size but not real level. Restroom / shower house outdated but fairly clean.
Love going there to ride the trails or walk my dogs the lakes are awesome great beach Great fishing awesome picnic areas nice boat launch. Most campsites are big with trees in between. Miles of biking and hiking trails
I just witnessed my first discrimination act. Very sad to see. Nice young couple trying to enjoy the park, very sad on park officials part to integrate the actions they chose to act on.
I stayed here July of 2019 and was not impressed. The cabin I stayed in was alright and clean enough. However, the fire pit was in a terrible spot, sitting about a foot from the lake. The parking was cramped and the cabins were extremely close to one another. The bathrooms were also not well taken care of and were disgusting by the end of the weekend. I also didn't realize it was right next to the expressway and it was loud. I don't see myself visiting again.
Overall this place was nice. Nice fishing pond, the cleanest bathrooms I've ever seen at a campground and nice walking path. The camp store was small but there are gas stations right down the road along with a Meijer and restaurants. It was a little off putting that they had golf cart patrols so often, but I appreciated the quiet. Well people quiet. The highways a littler closer then it looks, so you do get a lot of road noise. Especially when trucks hit the chatter bumps on the side. Not the worse thing in the world, but worth noting. Overall a nice place.
We love this place. We rent the river rustic site. It's right on the shore of the Muskegon river. There's enough for the kids to do! Playground and swimming pools are great!
Great to be so close to town and the beach. Not much of a "vacation" with such strict drinking rules and tight quarters.
The campsites are located past the playground and shelter. Just keep driving down the road that looks like an alley. There is a wonderful place set up for just a few campers.
A couple sites are for tents only and the others are standard sites. There are a few trees by the sites but it's mostly open area. Portable toilets are at the end of the camping area and in the playground area. The playground is a day use area for town so expect to meet some locals.
Driving just down the street takes you to the police station. This is where you register for the site. Town is around you and ready to explore. There are a few train tracks and industrial businesses which provide a bit of noise along with traffic. For us, the noise just slid right into the background.
This is a great place for a low price.
Nice family campground. Owners and staff are very friendly. Lots of planned activities for kids with weekend barrel train rides and hay rides. Playground and nice sandy swimming area. Only downfall is the proximity to the highway and lack of woodsy camping feeling. Restrooms are always immaculately clean. Close to Cedar Springs downtown. Plenty of dining option and great proximity to F. Meijer bike path.
This is a small campground with fairly good size sites. There is a playground in the center which was very handy for our little ones. They could play and we could watch from our site. The area was beautiful. The beach was clean and even had a snack shop where you could get a realest and rent a canoe or kayak.
The office was nice. It had a lot of good items, which I really appreciate when I come in late and needed to grab something quick to make (hotdogs!). There is also a candy shoppe in it. My kiddos could take a quarter to the office and pick out a treat.
The sites were very shaded and the bathrooms were very clean. If there is a downfall, it would be that the pieces of wood hat can be bought were huge! They had to be cut smaller to use well.
It has great nature opportunities too!!
Camp sites are well shaded and have a lot of space. Walking distance to Lake Michigan with beautiful view of the sunset. Bathrooms were clean and showers were okay considering it is a campground. There is a playground for kiddos as well as bike rentals. A lot to do within the State Park.
Only negative is to be prepared to level your RV. Our site was not even. Not all spots were this way, but you will definitely need blocks or what not.
This camp ground is very crowed, during the summer. The sites are close together, dirt, grass and semi-level. They have water, electric ,dump station, firepit & picnic table. There is a path to Lake Michigan. The beach is small but there is access to swimming. They also have an overlook, for a great sunset view. Park Wifi is very sketchy, even though we were right next to the transponder, probably with so many people trying to connect. Verizon phone gets maybe 2 bars at it's best , LTE & Verizon mifi, will be able to bring in 3G. All water spigots seem to leak and spray. However since it was so warm the kids seem to like it, however it does make a muddy mess. Each lot has room for a tent or gazebo. This park is huge and heavily wooded. If you're wanting your satellite to come in, there are only a few open spaces. We walked around it looked like site 76 and that general area, were open enough to get a clear shot. I would definitely stay at this campground again, but it will have to be off season, when there is a little more room to enjoy.
They overcharge for EVERYTHING! While there we over heard them planning a craft event (horse pool noodles) they said they paid $3.00 for all supplies combined and planned on charging each child $4.00! 🤬 They could careless if people drive the wrong way on their roads. The only plus to this place is the playground right in the middle of the park, oh and the $1.50 wagon ride! We'd never stay here again.
We found this campground last minute and it was our first time at a KOA. We usually camp at state parks but seeing we couldn't get into one we figured this would be the next best thing seeing it had a pool. We have two girls of the age of five so the pool, the hayride, the night hayride, two parks, jump pad, and feeding the goats kept them busy. There was a lot to do so we didn't feel the need to leave. We did venture out to a brewery 5-10 mins away in Allendale and Grand Haven is about 20-25 minutes away if you want to cruise out to Lake Michigan. The pool was clean and we had a lot on the pond. All of those sites were good size for small trailer. My only complaint was there were two buildings with showers and two showers each. A lot of the people that stay have RVs so the showers may not always be needed but I did notice there were lines for showers the day we left and I don't usually run into this with a state park. If we wanted to get away again we would camp here again. Plus the owner and his family is super nice!!
This campground was really nice and peaceful and there were lots of trees. We didn't have the best weather the weekend we went so there were a lot of tarps rigged up to provide shelter from possible rain.
There is a lake and really nice hiking trails that we took advantage of. The rangers were constantly patrolling (even at night) which was kind of weird. We couldn't buy firewood at the campground when we arrived.
Overall - good for a couple days, not our favorite.
5 friends and I drove out from Chicago to this campground and were pleasantly surprised by how great the campground and site were. I booked this site a month in advance during the summer so I must have just gotten really lucky! The site was cozy, not crazy spacious but enough for two tents and two cars.
The campground had a lot of motorhomes, families, and larger groups around us but it was still very quiet and peaceful. The rangers were really nice and you could buy ice and firewood at the campground.
There was a great 3.5 mile hike around the lake with really beautiful lake views and a great beach for swimming. We had an awesome time and would definitely come back here.
Good size lots, clean bathrooms, we always like to go there. There isn't much of a beach this year, but in town there are two bigger ones.
I loved this campground really. It wasn't overbooked, everything was clean the gal at the desk kind and helpful. We had the river right down from us which was nice to swim in on a hot day. Pure Michigan indeed!


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There's a broad vary of careers that you could pursue with a background in schooling, a lot of which you will never have considered. You can use your educating expertise for career alternatives in higher education, childcare administration, publishing, information science, journalism, sales, advertising, human sources and much more. We get rejected from fellowships, grants, academic journals and full-time jobs. Extra students are requiring flexibility in the academic structure to allow extra time for other areas of accountability. Obtained a tip for trying to find online educating positions or a favorite site?
Even in lower schooling degree, students are already competing with one another to find out who will get the highest grade in class. Postsecondary education directors help college students with a variety of tasks, such as registering for classes and completing admissions purposes.
Universities and additional education (FE) colleges make up the biggest proportion of employers. Although experts predict that financial restoration isn't far off, over the previous couple of years, there has been more strain for faculties to make sure their graduates have the required expertise to draw employers.
Work experience that's commonly considered crucial by employers, or is a commonly accepted substitute for extra formal sorts of coaching or schooling. A number one global academic writer is recruiting for a (Senior) Writer to fee merchandise for the UK HE Schools & Additional Education market.
And some states are already transferring away from the idea that the aim of main and secondary education is to arrange students for faculty, relatively than to arrange them to be productive members of the workforce. Haven't got the time to orchestrate advanced online job searches?


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Perspective Free access | 10.1172/JCI9460
Department of Genetics, Case Western Reserve University School of Medicine and Center for Human Genetics, University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
Phone: (216) 368-3331; Fax: (216) 368-3432; E-mail: firstname.lastname@example.com.
Find articles by Nicholls, R. in: JCI | PubMed | Google Scholar
First published February 15, 2000 - More info
The majority of genes are inherited in 2 copies, 1 from each parent (the exceptions being sex-linked genes in males and mitochondrial genes). Whereas most such genes have identical functions, imprinted genes usually function only when inherited from either the mother or the father. Imprinted genes are marked in the male and female germline and retain molecular memory of their parental origin, resulting in allelic expression differences during development. Over 35 imprinted genes have been identified to date in the combined human and mouse genomes, representing perhaps 5–20% of those predicted to be imprinted (1, 2). Abnormalities in imprinted inheritance occur in several well-known developmental and neurobehavioral disorders, including Albright's hereditary osteodystrophy and Angelman, Beckwith-Wiedemann, and Prader-Willi syndromes. Each of these diseases involves complex genetic loci and gene regulation and will be compared in this article. Recent studies have also demonstrated directly a role for imprinted genes in determining brain development and for 2 paternally expressed genes in regulating maternal behavior in mice. Here I will review evidence that imprinted mammalian genes influence complex neurobehavioral phenotypes, including psychiatric disorders. Such observations have significant implications for genetic approaches to identifying the etiological genes involved in these and other similar complex traits.
Clinical features of Prader-Willi syndrome (PWS) include postnatal failure to thrive with childhood onset of hyperphagia and severe obesity, and short stature with neurosecretory growth hormone deficiency (3). Other neurobehavioral attributes of PWS include developmental delay, mild to moderate mental retardation, learning disabilities (with strengths in reading, speech, and long-term memory and weaknesses in arithmetic and short-term memory), obsessive-compulsive disorder, temper tantrums and stubbornness, poor social interactions, abnormal sleep, hypogonadotropic hypogonadism, temperature instability, and, in 5 to 10% of patients, psychosis. In contrast, the Angelman syndrome (AS) clinical phenotype is characterized by severe neurological features, including developmental delay, ataxia, severe mental retardation, lack of speech, paroxysms of laughter, seizures, hyperactivity, attention deficit (with poor social interactions), sleeping difficulty, aggressive behavior, and tongue protrusion.
The genetic aberrations in PWS and AS include a common 4-Mb 15q11-q13 deletion of paternal or maternal origin, respectively, or maternal uniparental disomy (UPD) in PWS and paternal UPD in AS (Table 1) (4, 5). These 2 genetic classes indicate that the PWS gene(s) are normally expressed only from the paternal allele and are silent on the maternal chromosome, with the opposite pattern and a maternally expressed gene causing AS. The latter has been identified as the UBE3A gene, because specific mutations occur in familial and sporadic patients (Table 1) (5). Intriguingly, UBE3A typifies a growing number of mammalian imprinted genes, in that it only displays imprinting in a tissue-restricted manner. Thus, maternal-only expression of UBE3A occurs only in certain regions of the human and mouse brain, such as cerebellar Purkinje's cells and hippocampal neurons (5), with biparental expression in all other tissues. These observations explain the neurological-specific phenotype of AS.
Complex molecular basis of 3 imprinted, developmental disorders
In contrast to AS patients, individuals with PWS of the classic type always have chromosomal abnormalities — large deletions, UPD, or an imprinting mutation (the latter discussed below) — affecting multiple genes. As seen in Table 1, no patient has inheritance consistent with a single gene mutation, suggesting that PWS requires the loss of function of 2 or more paternally expressed genes (3, 4). Indeed, multiple genes have been identified across a 1.5–2-Mb region of human chromosome 15q11-q13 that are expressed only from the paternally inherited allele (Figure 1a) (3, 4). The deletion interval associated with PWS also includes the maternally expressed UBE3A gene and several nonimprinted genes (Figure 1a). The finding of many paternally expressed genes presents a major obstacle to identifying the critical imprinted genes involved in PWS, because each of these, or others not yet identified, may play some phenotypic role in PWS. As the 15q11-q13 genes are identified from the human genome sequence and allele-specific expression assays, it becomes possible to test their contribution to the PWS phenotype, either by generating mouse models or by studying people with specific components of PWS for evidence of mutations in the gene of interest. Of the PWS candidate genes, one intriguing locus (SNURF-SNRPN) is polycistronic and encodes 2 functional proteins (3). This complex locus is of considerable interest because it specifically shows microdeletions (7–200 kb) in patients with mutations in the imprinting process, indicating an involvement in the regulation of imprinting in 15q11-q13 (see below).
Complex structures of imprinted gene loci. (a) Genetic map of the 2-Mb imprinted domain in chromosome 15q11-q13 associated with PWS and AS. An IC is associated with the 5′ end of the bicistronic SNURF-SNRPN locus. Blue or pink circles, imprinted genes showing expression of only the paternal or maternal allele, respectively; open squares, nonimprinted genes; small arrows, overlapping and antisense transcription; large arrows, regional imprint control through an IC; zigzag lines, common breakpoint (BP) regions for deletions. (b) Genetic map of the 1-Mb imprinted domain in chromosome 11p15 associated with BWS. Symbols are the same as in a; colored squares represent genes imprinted in some tissues in mice, but not yet shown in humans. Three loci have been specifically implicated in the pathogenesis of BWS. The 5′ H19 region appears to act as a local IC regulating imprinting at IGF2, whereas a 5′ CpG-island for LIT1 (KvLQT1-AS) has been proposed to perhaps (denoted by ?) act as an IC for either CDKN1C, IGF2, and/or other genes in the 11p15 domain. (c) Genetic map of the 75-kb GNAS1 locus in chromosome 20q13. Three alternative promoters of transcription all lead to splicing to a common set of 12 downstream exons. Each exon 1 region has a different pattern of parental origin–specific allelic methylation and transcription, and each leads to a different encoded protein product.
Although a few balanced translocations occur in PWS (Table 1), the molecular basis is not understood (3). Two patients with classical PWS have a translocation breaking within the bicistronic SNURF-SNRPN gene and express all tested paternally expressed genes in 15q11-q13, implicating the disrupted locus in PWS. However, the translocations in 2 patients with atypical "PWS-like" phenotypes lay distal of SNURF-SNRPN but proximal to the IPW gene (Figure 1a), which may indicate a role for genes at or on the distal side of the translocation. A unifying hypothesis is that the translocations affect neuronal chromatin structure, disrupting the function of multiple genes within 15q11-q13 through some form of position effect. Whereas it is also possible that the germline imprinting process (see below) is affected, the imprint may already have been set before the chromosome rearrangement, and this hypothesis is not fully compatible with the expression and methylation data.
Several mouse models have recently been developed for PWS or AS. These include animals with UPD and strains that carry a 4-Mb deletion affecting the region of the mouse genome that corresponds to human 15q11-q13. Interestingly, the deletion model segregates mouse phenotypes that mimic both PWS and AS, depending on the inheritance of the mutation. In addition, an imprinting mutation, discussed below, causes features of PWS, and targeted mutations of the murine Ube3a gene have been used to study AS (reviewed in ref. 6). The AS models display a mild neurobehavioral phenotype, observable only on careful testing, whereas the PWS mouse models all fail to thrive and often die shortly after birth. Failure to thrive is also seen in infants with PWS, and recent mouse studies involving gene-specific knockouts suggest that this phenotype involves the additive contribution of several genes (6), including the NDN gene, SNURF-SNRPN, and/or an unknown gene between the latter locus and IPW (see Figure 1a) (6). By restoring these genes individually into PWS mouse models it may be possible to identify their contributions to the various phenotypic components of PWS. Ultimately, therapeutic intervention in PWS or AS will require a fuller understanding of the biochemistry and physiological roles of the products of these genes.
Molecular analysis of 2 disorders, Beckwith-Wiedemann syndrome (BWS) and Albright hereditary osteodystrophy (AHO), provides the clearest examples of imprinted genes that regulate growth and development, although Table 2 indicates other developmental disorders that show similar, but less well-understood, effects. As for PWS and AS, the molecular basis of BWS is extraordinarily complex. The genetic mechanisms underlying BWS include paternally derived duplications, UPD, and loss of imprinting (LOI) at IGF2, implicating a role for a paternally expressed gene, and maternally derived translocations and specific CDKN1C (p57KIP2) mutations, implicating a role for a maternally expressed gene (Table 1) (7, 8; Maher and Reik in this Perspective series). Mouse model studies suggest that in some tissues, where both are expressed, IGF2 and CDKN1C antagonize each other's effects on cell cycle progression (9). Nevertheless, these 2 oppositely imprinted candidate genes are located over 500 kb apart and may be located in independently regulated imprinted domains (Figure 1b). Detailed mutational studies in the mouse have clearly shown that the 5′ H19 region is able to regulate the imprinting of H19, Igf2, and Ins2, but that this domain is independent of the other imprinted genes in chromosome 11p15 (Figure 1b) (2). It is unclear whether, or to what extent, the imprinting of these other genes is coordinately regulated. Evidence for long-range chromatin effects is provided by the occurrence of translocations in BWS patients within KvLQT1 (Table 1), which, though imprinted in most tissues, is clearly not the target gene, because recessive and dominant cardiac diseases occur as a consequence of the lack of imprinting in this tissue. Furthermore, recent studies have identified a paternally expressed antisense transcript (KvLQT1-AS or LIT1) associated with a differentially methylated CpG-island and shown that LOI at this locus is the most common abnormal epigenetic alteration in BWS (Table 1 and Figure 1b) (7, 8; Maher and Reik, this series). In some, but not all, of these translocation and LIT1 LOI cases, there is also LOI at IGF2. Hence, it is not clear if this genetic element acts as a general imprint regulator (Figure 1b) or if these BWS epimutations specifically interfere with gene regulation of CDKN1C (7, 8).
Selected developmental and neurobehavioral disorders and genes with evidence for an imprinting effect
AHO is associated with short stature and skeletal defects and arises due to dominant inactivating mutations in the GNAS1 gene encoding the α-subunit of the heterotrimeric G protein Gs, as does a more severe disorder with AHO and the hormone-resistant syndrome termed pseudohypoparathyroidism type 1a (PHP-1a; Table 2) (10). Isolated parathyroid hormone resistance (PHP-1b) is also linked to the same locus, although Gsα levels are normal. PHP-1a and PHP-1b arise from exclusive maternal inheritance, whereas AHO alone occurs within PHP-1a pedigrees after paternal inheritance. Oppositely imprinted endocrine, behavioral, and morphological phenotypes also arise from UPD at this locus or from the targeted disruption of exon 2 of the mouse Gnas gene (see ref. 11 for review). The disease complexity at this locus may be explained by its remarkable genetic structure (Figure 1c) (10, 11). Although Gsα is encoded by the nonimprinted exons 1-13 of GNAS1, 2 upstream alternative promoters are found in this locus, and, as seen in Figure 1c, these sequences are oppositely imprinted. Thus, the first exon under control of each of these promoters is spliced with exons 2–13 of GNAS1 to generate the maternally expressed NESP55 or the paternally expressed XLαs. The latter 2 proteins appear to be coexpressed, and both are involved in formation of neuroendocrine secretory granules (10). The inheritance patterns produced by mutations at this locus in the mouse or in human PHP-1a could be explained by interference with transcriptional or splicing regulation at GNAS1 (10, 11) or by antagonistic roles of the 3 proteins translated from this bizarre locus. AHO may arise solely from 50% reduction in Gsα, with or without an effect on XLαs, whereas PHP-1b mutations may occur in NESP55. Further mutational studies in both species will be needed to clarify these issues.
It is clear from the preceding discussion that imprinted genetic disease is associated with complex inheritance patterns and elaborate gene loci often comprising large clusters of imprinted genes (Figure 1). Other than allelic transcription differences, the epigenetic modification most clearly demonstrated for imprinted genes is the differential patterns of allele-specific DNA methylation in somatic tissues, dependent on the parent of origin (2, 12). Differential and specific DNA methylation imprints have been identified within several imprinted genes in sperm and oocytes, and in several cases, experimental studies in the mouse have shown that these represent the gametic imprints (molecular memory of parental origin) transmitted to the next generation. However, recent studies have implicated a wide range of gene-specific and chromatin-domain features in the regulation of imprinted gene expression in somatic cells (2, 7, 8, 12, 13). These include differential histone H4 and H3 acetylation, nuclease sensitivity, and nuclear matrix association, as well as the presence of G-rich direct-repeat sequences in or near CpG-islands, oppositely imprinted antisense RNA transcripts (see above), and asynchronous DNA replication and homologous chromosome association. Nevertheless, whereas many of these factors may help maintain imprinted domains in somatic cells or be secondary events consequent to differential packaging of chromatin on the 2 alleles, the respective roles in establishing the imprint in germ cells or after maternal and paternal pronuclei fusion after fertilization remain unknown.
Imprinting is a reversible process requiring the previous parental imprint to switch in the germline of progeny of the opposite sex. Mutations in this process occur in approximately 3% of AS and PWS patients, and particular insight into the molecular mechanism has come from study of those patients with heritable microdeletions in 15q11-q13 (Table 1) (4). Although the genotype of such imprinting mutation (IM) patients appears normal, their pattern of DNA methylation and gene expression — that is, their epigenotype — is abnormal, with maternal-only imprints in PWS and paternal-only imprints in AS.
Familial transmission of such epigenetic defects results from specific microdeletions in this region, but many IM patients are sporadic and have no detectable mutation; stochastic events during parental gametogenesis probably account for this class of imprinting defects (Table 1) (4). Inherited microdeletions in familial PWS and AS IM patients occur at the 5′ end of the SNURF-SNRPN gene, defining a region termed the imprinting center (IC; Figure 1a). The IC is thought to regulate initiation of the parental imprint switch in the male and female germline (4, 13), leading to the establishment of heterochromatic-like DNA at the IC in oocytes and euchromatic-like DNA at the IC during spermatogenesis. Subsequently, these chromatin states may propagate bidirectionally and consequently regulate imprint switching for all genes over the 2-Mb imprinted domain (Figure 1a) (13). Both the familial and sporadic forms of IM effects are remarkable among human genetic diseases in that the IM acts, not in the affected patient, but rather in the parental germline, where it blocks the switch of the grandparental imprint. Clinical manifestations occur only because the offspring has inherited the incorrect grandparental imprint.
An understanding of the molecular events underlying these cases may also lead to insight into the basis of imprinting mutations at the H19, IGF2, and LIT1 (KvLQT1-AS) genes in chromosome 11p15 in BWS and in human embryonal tumors (Table 1) (7, 8; Maher and Reik, this series; Tycko, this series). In these diseases, the epigenetic changes usually occur sporadically and hence are probably somatic in origin. At present, the primary genetic or epigenetic events causing these changes are unknown, and this is paralleled by our ignorance of the primary events causing sporadic IM in PWS and AS. Identification of these events will have a significant impact on our understanding of how imprinting occurs and whether it may one day be feasible to manipulate the epigenetic state of an normally silent imprinted allele as a therapeutic approach in imprinted disorders.
Imprinted genes have been indirectly implicated in brain function and behavior as a consequence of the genetic defects in well-studied syndromes such as PWS, AS, and AHO, although the roles of such genes in growth processes have received greater attention. However, recent experimental studies in the mouse have more directly indicated an important role for imprinting in regulating brain development and behavior. The first evidence for imprinting in mice came from nuclear transfer experiments that generated parthenogenetic and androgenetic embryos, the former containing a diploid maternal genome and the latter containing a diploid paternal genome. This work established that the 2 parental genomes play complementary developmental roles, and subsequent experiments revealed that tissues are differentially affected by uniparental development. Using chimeras between normal and uniparental cells to overcome the lethality seen in parthenogenetic and androgenetic embryos, it has been found that androgenetic cells contribute to, or survive in, specific tissues, including placenta, muscle, and certain brain structures, but that the maternal genome contributes to other brain structures and to a greater extent to brain growth (2, 14). A high proportion of parthenogenetic cells in the brain was also associated with male aggression. The paternal genome contributed primarily to regions important for primary motivated behavior, such as the hypothalamus, but androgenetic cells were excluded from the neocortex and striatum, areas that showed selective accumulation of parthenogenetic cells (14).
Two recent studies are of particular relevance to understanding the roles imprinted genes have in growth and behavior. Mutations were targeted into the mouse Mest and Peg3 genes, resulting in both instances in a moderate postnatal growth retardation up until weaning at 4 weeks of age and an intriguing effect on maternal behavior following grandpaternal transmission of the mutation (15, 16). Thus, most offspring of such females do not survive, because the mother fails to retrieve, feed, or warm the pups; these females also lack such typical maternal behaviors as nest building and consuming the placenta after pups are born. In the case of Peg3 mutations, a maternal lactation defect with a reduced number of oxytocin-positive hypothalamic neurons may contribute to this phenotype (16). Both paternally expressed genes therefore appear to play roles in controlling postnatal growth and nurturing behavior in mothers.
Perhaps the best supported theory for evolution of imprinting is that a parent–offspring "conflict" results in enhancers of prenatal and postnatal growth being of paternal origin, whereas those of maternal origin should be growth suppressors (2, 17). Parent–offspring conflict arises from the dependence of mammalian offspring on maternal resources from conception through weaning and the potential involvement of multiple paternity. This model fits well with the proposed antagonistic roles of paternal IGF2 and maternal CDKN1C expression in promoting and inhibiting growth, respectively, and for several other imprinted genes (2). Similarly, we have proposed that selection for imprinting in the PWS region arose for a postnatal growth advantage to a paternally derived gene, given the failure-to-thrive phenotype of PWS neonates and PWS mouse model pups (3). However, this selection pressure need only operate on a single gene within a large, coordinately regulated imprinted domain, and most genes within the domain may display imprinting simply as a consequence of recent evolutionary acquisition by the domain or as a consequence of the spreading effect of the imprinting mechanism.
The parent–offspring conflict hypothesis has been expanded to explain the grandpaternal role of Mest and Peg3 in controlling maternal behavior for the survival and care of offspring to ensure growth enhancement postnatally (15, 16). More generally, this hypothesis can also be related to evolutionary changes in mammalian brain growth, in which the expansion of the neocortex and striatum associated with social behavior can explain the role of the maternal genome in contributing to these structures (14). Similarly, the predominant contribution of the paternal genome to the hypothalamus and other structures involved in reproduction, feeding, and growth, may account for the relative contraction of these regions in the brain during the evolution of primates and humans. These changes provide a genetic explanation for complex neural development and behavior.
Recent studies provide additional genetic clues implicating imprinted genes in complex neurobehavioral phenotypes, including susceptibility genes involved in alcohol preference and audiogenic seizures (Table 2). In addition, evidence for linkage of candidate loci to bipolar affective disorder is, in some cases, sensitive to the parent of origin of the putative disease allele. Similarly, a lower age of onset of one subtype of schizophrenia after paternal inheritance and of Tourette's syndrome after maternal inheritance, or an increased incidence of familial neural tube defects maternally transmitted and late onset Alzheimer's disease paternally transmitted, may indicate underlying imprinted genes (Table 2). In one intriguing example, social cognitive skills were better for Turner's syndrome patients inheriting the paternal, rather than the maternal, X chromosome (Table 2). Until the relevant imprinted genes associated with these disorders are isolated it will not be possible to prove the imprinting hypothesis in such cases, and the occurrence of tissue-specific and mRNA isoform-specific imprinting (discussed above) or polymorphic imprinting (18) will potentially complicate the identification of these genes. However, the insight from the cited studies that imprinting allows susceptibility alleles to be transmit silently from parents of one sex within a pedigree may account for some of the difficulties in psychiatric genetics that are otherwise ascribed to environmental modification of the phenotype, variable expressivity, incomplete penetrance, or genetic modifiers.
The work discussed here clearly indicates the complementary requirement for normal development and neurobehavioral function of inheritance deriving from the mother and the father. These studies also highlight the potential for significant advancement in multidisciplinary fields ranging from genetics and epigenetic regulation to behavioral sciences, development, and pathology, which will further aid development of therapeutic approaches to developmental and neurobehavioral disorders.
I thank Ben Tycko and John Ashkenas for comments on the manuscript and all students and colleagues who have contributed to our work in imprinting. In many instances recent reviews have been cited because of space restraints, and I apologize to all whose important primary work was, consequently, not cited. This work is supported by the National Institutes of Health (HD-31491, HD-36079, and HD-36436) and March of Dimes Birth Defects Foundation (6-FY99-390).
Epigenetics and its role in disease
Benjamin Tycko et al.
Beckwith-Wiedemann syndrome: imprinting in clusters revisited
Eamonn R. Maher et al.
Gene silencing as a threat to the success of gene therapy
Timothy H. Bestor
The impact of genomic imprinting for neurobehavioral and developmental disorders
Robert D. Nicholls
Epigenetic gene silencing in cancer
Benjamin Tycko


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