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Start 2018 with 12 Months of Puppy LoveGive the Gift of Independence and Give a Dog a Job® for People with Disabilities December 11, 2017
SANTA ROSA— What's better than puppy breath and sweet puppy kisses? Well not much, but how about the next best thing -- the 2018 Canine Companions for Independence® Puppy Wall Calendar. It's 12 months of adorable canines. And these puppies have a purpose, hoping to become life-changing assistance dogs for an adult, child or veteran with a disability.
Plus, this heartwarming calendar includes $18 in coupons for Eukanuba dog food. Get your puppy calendar with $25 donation today at cci.org/calendar.
Canine Companions for Independence, the largest non-profit assistance dog provider in the nation, provides expertly trained assistance dogs free of charge to people with disabilities. Professionally trained to perform over 40 different commands such as pick up dropped items, open a door, turn on the light switch or alert a handler who is deaf or hard of hearing to important sounds in the environment. The result is a life full of increased independence and loving companionship.
Looking for more great canine gift ideas? Visit the official Canine Companions online store for puppy holiday card packs, gifts for your special canine and hundreds of other products that all support placing assistance dogs to increase independence. Visit cci.org/shop today.
Canine Companions has placed more than 5,500 assistance dogs since its founding in 1975 with children, adults, wounded military and professionals that work with people with disabilities. This holiday season, Give the Gift of Independence and Give a Dog a Job with a little something extra for under the tree.
About Canine Companions for Independence
Non-profit Canine Companions for Independence provides highly-trained assistance dogs to children and adults with disabilities. Established in 1975, Canine Companions has six training centers across the country. Canine Companions is recognized worldwide for the excellence of its dogs, and the quality and longevity of the matches it makes between dogs and people. For more information, visit www.cci.org or call 1-800-572-BARK.


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Kalea Chair
Collection: Kalea
Design: Lorenz+Kaz 2011
Description: Chair, ash or oak timber frame; multi-ply veneered or fabric and leather upholstered seat and COL or COM client's own leather or fabric; available in a large range of stains and open grain lacquer coated.
Total height cm. 78
Seat height cm. 47
Seat width cm. 55,5
Seat lenght cm. 47,5

subset: commoncrawl


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- Just Released
- Sale Bestsellers
- Advent & Christmas
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- Bible Study & Small Group
- Bulk Discounts on Books & Bibles
- Christian Book Award Winners
- Dove Awards Winners
- New & Bestselling Fiction
- Gifts for Her
- Gifts for Him
- Keep Kids Safe Online
- Lifeway Resources
- New Year's Resources
- VeggieTales
- Wedding & Marriage
Our Blog
Welcome to our new Blog! We are excited to have this opportunity to interact with you and help keep you informed on all the great things that are going on. Our site is a great place to discover the many ways we can help you with books for leisure or study, music for a long car trip or to sing along to in your car, DVD�s for you and the kids and more! Check back often for new information and leave us questions or comments so we can help serve you better.
We here at Living Truth are very concerned that Family Christian Stores are closing. Since we opened in 1998, 1/2 of the Christian stores in the greater Indianapolis area have closed. We want you to know that we are open to serve you. If you have a FCS frequent shoppers card, bring it in and we will convert that card to our Laity Money card. We will match the number of punches you have on your card. We will and add 3 more punches to your card during the month of March if you make a purchase at the time of conversion. We look forward to serving you soon.
On October 23rd, we celebrate 16 years of service here at Living Truth. We are pleased to say that through you, we have merchandise purchased from here on almost every continent in the world. Thank you for helping us serve our risen Savior and His charge to us as disciples to share Him with those who do not know of His saving grace.We have artists and authors here on the 18th and the 25. Also, on the 18th, 23rd, & the 25th you will receive a pack of 12 coupons with 20% off savings on them with your purchase.In addition, bring in your church bulletin from the 18th, 19th, 25th, or 26th and receive 16% off your purchase of non-sale in stock merchandise. This offer is valid from 10/20-11/1/2014.
Living Truth is excited to partner with Good Samaritan to help those in need in Hamilton County. Our county is the 5th richest county in the nation and the richest in Indiana, however, there are many in need of support. Good Samaritan is there to help those in need, and Living Truth is now a drop off site for items that will be used for those in our county that cannot purchase these items themselves. We are accepting the following items:
School Supplies everything from pencils to backpacks
Food non-perishable, including personal care, cleaning, and paper products
Toys new or like new
Clothing for all ages and sizes - new or like new
You may drop off your donations during our store hours:
Monday-Friday: 10:00 a.m. to 7:00 p.m.
Saturday: 10:00 a.m. to 5:00 p.m.
When we partnered with Midwest Food Bank and WGNR for the flood relief, I was overwhelmed at the generosity of those of you who dropped off items to meet that need. They came 8 different times to pick up all the donated items. I know that you will give to meet the need in our county as well.
In Christ,


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Teaching Tips
Here's some guidance on teaching to help you get started:
Encouraging learners to contribute
Your learner may be excited and enthusiastic, but may also be overwhelmed at the prospect of one-to-one attention focused on their abilities and efforts.
Potential Issues
Here are some of the barriers you may need to overcome in order for lessons to be successful:
- Difficulties communicating. Your learner may struggle to explain what it is they are finding difficult or what they want to achieve.
- Your learner may also feel a little intimidated and need encouragement to contribute until their confidence has been established.
- Your learner may be unclear how to work with a teacher on a one-to-one basis.
How to encourage learner contributions
You can help learners to engage by ensuring:
- They feel comfortable with you and happy to ask questions
- Respect is shown and support is given
- Learning is seen as an exercise you do together for fun
- They feel their participation is valued
- Any goals you set are realistic and achievable
- Contribution and ideas are encouraged
How to open a lesson
Ensure your learner has a sense of how the lesson will be directed by giving a brief introduction to your planned activity and then asking open questions to confirm the learner has understood.
As the lesson continues
Ensure you:
- Give friendly feedback
- Encourage focus
- Correcting misunderstanding
How to feedback to a learner:
- Comment on use of particular skills
- Encourage practice of neglected skills
- Give constructive feedback and try to link to specifics
- Be encouraging and friendly when commenting on work
Finishing lessons on the right note
Try to gauge your learner felt about the lesson by asking a few light questions such as "What has been the most useful thing you have learned today?" or "Do you have any questions following what we have talked about today?"
Evaluating your teaching
As you work with more learners you may wish to start contemplating what worked/what didn't, in addition to any feedback First Tutors: Arts & Crafts receives from learners. Below is some "food for thought" to help you in the process.
|How well did I .....?
|Very Well
|Could Be Better
|Prepare for the session
|Get the session underway (establish aims, etc)
|Ask questions and prompt the learner
|Handle the learner's comments and questions
|Respond to the learner as an individual
|Keep the focus on the main topic
|Help sustain learner interest
|Provide help when learners encountered difficulties
|Ensure key points were drawn out
|Bring things to a close and set out practice homework
New to Arts & Crafts Teaching?
If you are new to private Arts & Crafts teaching you are welcome to register with First Tutors: Arts & Crafts to attract potential learners.
We will ask you which subjects you are proposing to teach, how much you wish to charge and what experience and qualifications you can offer.
Choosing your Subjects
Carefully consider which subjects you feel you can offer with credibility to your audience. We ask learners to give feedback about teachers and the best way to ensure this feedback is positive is by making sure you are teaching a subject well within your comfort zone of knowledge.
Starting with a new learner
First impressions matter, so ensure you give the right impression to your new learner by picking up the phone to contact them swiftly rather than leaving them to chase you. Learners can be anxious when making arrangements with a teacher, especially if they have exams to consider, so put them at ease by making arrangements quickly, showing up on time and arriving well prepared.
Public Liability & Professional Indemnity Insurance
Harbour House
126 Thorpe Road
01953 455 600
01603 218 000
Following enquiries from our members, we are delighted to introduce Alan Boswell Group as our recommended insurance broker for private tutors seeking liability insurance. Please find details of their policy below. Enquiries regarding the policy should be directed to Alan Boswell directly as we are not properly qualified to advise on the product itself. We do hope that some of you may find this useful.
The Alan Boswell Group has considerable expertise in arranging bespoke insurance products for the teaching profession. They have been established for many years growing to become one of the largest independent Insurance Brokers in the UK and are committed to providing the highest possible quality of service.
Examples of the cover we can provide?
Here are a few examples of the cover they can provide:
- Cover for your personal liability as a result of your negligence for injury or damage to pupils and their property whilst being taught in your own home.
- Cover for damage to property or injuries caused to others by your negligence whilst teaching in their home.
- Cover for failure to provide adequate tuition services or errors in your selection of curricula or coursework.
Peace of mind from just £100 a year
Fortunately, the cost of getting comprehensive protection for the risks involved with your work as a tutor is much lower than you might have expected. Thanks to a special policy arranged by Alan Boswell Group, insurance for public liability and professional indemnity with a £1 million indemnity limit is available from just £100 a year.
Find out more and get instant cover in minutes at www.alanboswell.com/first-tutors.


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My question is on duplicating the products does the meta fields of the products also duplicates. If yes, in what way I can achieve this in order to duplicate the metafields also . As I have many products.
Thanks for reply in advance
This question has received the maximum number of answers.


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So um...I've been inactive for a butt-ton of time. So forgive me. I'm Simon, by the way.
Anyway, Steam has WarHammer 40K content on sale, and I had all but the last expansion (Soulstorm???) and I was thinking of getting it. I had quit the game at least two years ago or so because I didn't feel comfortable with the demonic stuff with the Chaos Legion, I never played as them but I still didn't like it. (Actually my fav are Necrons. ) So I was wondering what your thoughts on that sort of stuff in it was, and if I should buy the expansion even if I don't play it any time soon in case I ever do.
Thanks, God bless.


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Traveling on a budget? You need a discount rental car in Redding.
Now that you've traveled all the way to Redding, the last thing you want is to miss out on the sights and attractions because you were late for your bus, or can't find a cab. Skip the hassle of public transportation and travel on your own schedule when you book one of these great Redding car rental deals. Travel comfortably and select the car class that you need from our Redding rental car deals below!


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Bocce Ball
Our Bocce Ball courts are open first come, first serve during our regular business hours for small groups. Any participants under the age of 21 must be accompanied by an adult and may not be on the courts unattended. So that we can maintain the courts in good playing condition for those who would like to play bocce ball, we respectfully ask that the courts not be used as a sandbox!
Bocce Ball Leagues
League registration will begin in late February/early March. If you are interested in getting a team together to play, please email email@example.com. All teams from previous year will be have first priority registration. All league participants must be 21+. Teams of 4, but you may roster up to 6.
Leagues run end of May through August.
Thursday Session 1
May 23rd – July 11th (skip July 4th)
Make-up date will be Friday, June 28th
If a game gets canceled due to weather, the schedule will delay one week
If the tournament game is canceled, it will reschedule to July 12th.
Thursdays Session 2:
July 18th- August 29th
Make-up game for regular season if needed will be Friday, August 23rd.
If the tournament game is canceled due to weather, the make-up date will be Thursday, September 5th.
June 23rd- August 18th
No play July 28th – Waconia Wine Festival
Make-up game August 25th
Game times 1pm and 2pm
The Objective of Bocce
The object of Bocce is to get as many of your bocci (bigger, weighted balls) as close to the jack (smaller target ball) as possible. If you are successful in getting the bocci closer to the jack than your opponent, you will be awarded points. Each team has 4 players maximum, if a team has less than 4 players, the missing player's turn is skipped unless the opposing captain declares that a player can fill in a second turn. Two players for each team go to each end of the court or side. There are 4 balls to a side, or team, and they are made in two colors or patterns to distinguish the balls of one team from the 4 balls of the opposing team.
A coin toss decides who will take the first throw of the jack. The jack is thrown out by a member of the team having won the coin toss to start the game. The same player throwing the jack must deliver the first bocce ball.
Scoring in Bocce
Only one team scores points during a single frame. If Team A has the closest throw, and Team B has the 2nd and 3rd closest, only Team A is awarded a point. A team can be awarded up to a maximum of 4 points, if all four of their bocci is closest to the jack. This "nearest ball", rule governs the sequence of thrown balls. The side whose bocce is the closest to the jack is called the "in" ball and the opposing side the "out" ball. Whenever a team gets "in" it steps aside and allows the "out" team to bowl. A team has the option of rolling, throwing, bouncing, banking, etc. its ball down the court provided it does not go out of bounds or the player does not violate the foul markers. A player also has the option of "spocking" or hitting out any ball in play in trying to obtain a point, or decreasing the opposing team's points.
Time Limit and Scoring
At the end of each frame (when both teams have exhausted 4 balls each), a designated official or designee of each team, will determine the points scored. This person will also be responsible for keeping track of the matches (3- 20 minute matches per game).
Scoring points are all those ball of one team closer to the jack than the closest ball of the opposing team, which can be determined by viewing or by mechanical measurement.
In the event that the two balls closest to the jack belong to opposing teams and are exactly the same distance from the jack, no points will be awarded, and the jack returns to the team which delivered it. Only balls which are distinguishably closer to the jack than any opponent's balls may be awarded points.
Each game will consist of three 20 minute matches. The winner of the game is the best of 3 matches with no score limit during those 20 minutes. Ties are reported as well if no winner is established within those 20 minutes.
Reporting Results
The winning team of each round will be responsible for reporting the results to the Schram team member working in the tasting room. Schram will keep records of all rounds. The 7th week of play will be the finals. Match-ups will be determined based on season team records and the play will be a single elimination tournament.
History of Bocce Ball:
Bocce ball, otherwise known as bocci, boccie, volo, lawn bowling, or Italian bowling, is played with the small ball, also known as the jack or pallino, and eight larger balls. The jack acts as a target as bocce balls can be thrown or rolled, with points given to the team closest to the jack.


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Don't worry, I haven't got the title of that Spice Girls song incorrect, I'm referring to how I used to have three bridesmaids, and now I only have one!
I never thought I would have a problem with three of my closest friends, who I've grown up with since high school. We've seen each other move into different careers and had highs and lows in our personal lives, but we've grown into women who have made a success of their lives. So when I asked all three of them to be my bridesmaids, I thought the plans for the wedding would be a breeze with their help on my side. How wrong I was!
It's turned out to be one of the most difficult aspects of the whole day and I've become increasingly more anxious and concerned about it. It all started when two of them had a falling out. Now this happened before I asked them to commit to being a bridesmaid but they both agreed they would be amicable for the sake of one day. Alas, this was not to be. It's turned into childlike behaviour with little digs and comments about each other to me. They haven't dealt with it themselves and instead are playing me as the middle man.
Where it went wrong
It all came to a head when one of them arranged a second hen do and purposefully left out the other, so she felt excluded. The excluded one then came to me and expressed her anxiety at the situation and bowed out of bridesmaid duties. I understood her concerns but still felt something different could have been done. She's not tried to work it out with the other bridesmaid and hasn't put much effort into making sure I feel less stressed about the whole situation.
Due to this derailment I didn't feel right having the other one as a bridesmaid, who had ultimately caused this drama by her own actions. So I told her how I felt and that I would be removing her from duties. This didn't go down too well, but ultimately she understood.
Shouldn't we be grown-ups?
Now why, at the age we are (mid-thirties), has this happened? I've spoken in previous blogs about how this is the one day when a bride should be able to have things her way, but I'm now left in a situation that isn't what I wanted. I have one very committed bridesmaid, who completely understands how I feel, but I'm left disappointed with two people who I thought could pull themselves together for just one day. I never thought organising a wedding would cause so many dramas but now I've had time to process the mess I'm left with five months before the big day, I feel a sense of relief. I now don't have to worry about the two of them staying in the same room the night before the wedding, I don't have to worry about any awkward meetings with them leading up to the big day and thankfully I don't have to worry about them 'working' together on the day itself.
Moving forwards
It may have taken a major falling out and some harsh words, but there are bigger and better things to be worrying about than a petty falling out between two people who can't get on for the sake of one of their best friends. I've got enough on my plate, talking of plates, I still need to put the order in for my chocolate wedding cake – I'll definitely need it!


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Volvo XC40 T5 2018 Road Test
The Volvo XC40 T5 is so exceptionally pleasant it's easy to understand why it was voted European Car of the Year. Now and again, a car comes together exactly right and, to Volvo's credit, that it what it has done with the XC40. Quiet, easy to get on with, a doddle to drive, yet capable of rocketing to 60mph in 6.2 seconds, without requiring Saudi Arabia's oil reserves to run. I saw up to 35.4mpg on V-Power and even averaged 34.64 over 911 miles including the fuel it came filled with.
Our John gave the XC40 D4 a rave review here.
Thoughtful touches abound. There are lots of places to put things or store things. The upright page-turning touch-screen works fine, except when having to use it to adjust things like the a/c temperature or the fan speed (best to have knobs for that).
The satnav takes instructions well, though isn't as good at spotting jams ahead and offering alternative routes as the Tom Tom in my long-term Koleos. But the TFT screen between the dials gives repeat instructions very clearly. It's extremely easy to pair a smartphone. The load area has a movable floor that enables you to secure bags so they don't slide.
Strangely, whereas we'd been less than impressed by a 310HP turbo petrol 4WD version of the new Volvo V60, the allegedly 247HP installation in the XC40 worked brilliantly and felt to me like a fair bit more than the stated power output. But that might be due to the way the 8-speed torque converter auto manages power in the XC40.
There are no paddles and seemingly no way of changing gear manually. There's just a forward and back lever that counter-intuitively puts it into reverse if moved forwards and drive when moved back. This seems to be the Volvo way unless you specify 'R Design', but it doesn't really matter. The Aisin Warner box gives you all the acceleration you ever need, doesn't get confused in corners and otherwise plops itself into the most relaxed ratio for the circumstances. 8th gives about 40mph per 1,000rpm.
Refreshingly, they also seem to have got the autonomous kit right in the XC40. Though the steering is quite light, it's very responsive, with just enough 'feel'. And when the steering assist engages it isn't overly intrusive. Just give a faint nudge, or a little bit of resistance if you change lanes without indicating. It's so easy to get on with that, instead of switching it off, I left it on for most of the time.
The active cruise control works well, too. Possibly too well, because on a long run with nothing much to do it leads you to get lazy. You end up not bothering to brake because the car is going to do it for you anyway and the lack of activity in your legs can leave you writhing with cramps. Not a criticism because you can always revert to driving the car yourself, but a potentially negative aspect of semi-autonomous systems.
Fuel economy definitely improved on V-Power. When the car was delivered the average was sitting at around 29mpg and stayed at 29-30 on the meter for the first 200 miles. A first partial fill of V-Power improved the meter reading to around 32mpg. And, at the end of a total of 1,066 miles it was showing 35.3mpg, not far short of its NEDC 39.8 and probably bang on the EU6d TEMP / WLTP figure.
At one point I pulled into Shell Barnsdale Bar on the A1 next to a TVR 350C and they'd run out of V-Power. The TVR took off, and so did I, then found myself beside him again 20 miles south at Shell Retford. "Has to be V-Power?" I asked. "Won't run on anything else," he replied. And that's the point. When Volvo first developed its current range of 2.0 litre engines I was talking to one of their engineers and he told me the injectors are optimised to run on the highest Cetane and highest Ron fuels. So that explains my improvement in economy, and also why some people who run their D4 diesels on cheap supermarket fuel are reporting a bit of injector trouble. It's not the injectors. It's the fuel, you fool.
The end of my week with the Volvo XC40 T5 came all too soon. It never put a foot wrong (or a wheel in the wrong place). Always pleasantly quiet and docile from start-up. And as quick as I ever wanted it to be out on the open road without making a lot of noise about it. It even rode well on its 235/50 R19 tyres.
I was utterly charmed by this car. Unexpectedly smitten.
I want one.
More at Volvo


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The Australian | 2 October 2012
The number of new undergraduates from overseas fell 12.8% in the year to August, latest figures show. Post-graduate commencements by overseas students rose slightly, compared with the same period last year.
Higher education starts in total were down by 6.7% to 82,825 in the year to August.
New university students from China, by far the biggest market, declined by 7.6% to 34,949 in the year to August, Australian Education International reported.
Higher education commencements out of India continued to grow, up 17.6% to 4931.
With enrolments of 11,896, India is not so far off Malaysia, the No. 2 university market by volume.
The slide in vocational education continued with enrolments down by 13.9% and commencements 11%.


text: Hello, My wife has the Droid (Verizon). I have the Samsung Galaxy (Verizon). I created a Calendar from my gmail account and shared it to her. The newly created calendar is not showing up on her (Droid) phone. I did the revears on her account and my phone can see her calendars fine. Any suggestions on this?


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You'd think that people would have had enough of silly mommy blogs
But I look around me and I see it isn't so
Some people wanna fill the world with silly mommy blogs
and what's wrong with that?
I'd like to know, because here I go again:
(apologies to Sir Paul McCartney for the above)
You may be wondering what in the world's going on in this little corner of the Internet.
Some days, I wonder that myself. *wry smile*
I am a SAHM, raising three children as well as taking care of my mother in the same house. Two of my children are from my first marriage (the oldest lives out of my home); two are with my husband who knows that neither of us are getting out of this marriage alive. As you can tell, we have a special brand of humor which helps us get through the day. The age spread of my children are 18, 15, 3, and 1. Yes, there's a 17 year age difference between my first child and my last child.
I do many crafts, a bunch for/with the wee ones, others for my own sanity. I love history and have been a reenactor (hope to start up again soon). I would say I could live in the past, but I happen to be attached to antibiotics and modern medicine (including dentistry that doesn't involve "welp, gotta pull that tooth!" as the primary method of resolving dental problems).
My husband and I are in an interfaith marriage, but since I'm not Christian many of the interfaith sites/books don't necessarily pertain to some of our unique needs. So we do the best we can, above all respecting each other. So far it's been working.
You may wonder… ok, what's up with the whole squirrel theme? Squirrels can represent balance. They work hard storing food for the winter, yet they still take the time to play. In real life they can be pests… but they are also a vital part of the ecosystem of the forest. And– the theme helps to open up a slew of nut puns *wink*
I'm sure there are other blogs that deal with these issues. But how many can say they have all these… together? I'm sure there's more. I know there's more. Check it out, I'm hoping to amuse, perhaps entertain, maybe even educate. Updates currently on a MWF schedule.


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- Mathematics
- Year 7
approx. 6 hrs
5 topics
17 concepts
Learn about the fundamentals of Probability in Year 7, including the language of chance, the different categories of probability and how they are recorded and calculated.
Cluey Learning – Tailored online tutoring for Years 3-12
approx. 6 hrs
5 topics
17 concepts
Learn about the fundamentals of Probability in Year 7, including the language of chance, the different categories of probability and how they are recorded and calculated.
The Year 7 Probability program is aligned with the Data and Statistics strand of the Australian curriculum. Students studying Probability explore theoretical probability, experimental probability in games, and they interpret probability data recorded on two-way tables and in Venn diagrams. This program also teaches students how to use the language of probability, which is a fundamental component of this topic.
This learning program is made up of the following 5 topics, broken down into 17 concepts.
Assign a probability between 0 and 1 depending on the likelihood of an event
Understand and use the language of probability
List the sample space of an event
Establish that the sum of the probabilities of all of the possible outcomes of a single-step experiment is 1
Calculate the theoretical probability of a single-step event
Calculate the complement of a single-step event
Calculate experimental probability of a small sample
Calculate the expected frequency of an event
Recognise the difference between mutually exclusive and non-mutually exclusive events
Describe compound events using the following terms: 'at least', 'at most', 'and' and 'not
Classify compound events using inclusive or exclusive
Calculate the theoretical probability of a single-step compound event
Interpret Venn diagrams involving two or three attributes
Construct Venn diagrams
Compare Venn diagrams with two-way tables
Construct two-way tables
Use two-way tables to calculate probabilities
Learning Content
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A spokesman for ICANN's "at-large" advisory committee has accused the organisation publicly of having lost touch with its philosophical "roots".
The ALAC committee deals with relationships between ICANN and that part of the user population which is neither business nor government - the section often called "civil society".
The relevance of this sector was clearly spelt out in the white paper inspired by the Clinton government that was ICANN's founding document, according to Siavash Shahshahani, of Iran, speaking at an introductory session of ICANN's Wellington meeting.
He invited delegates to compare this with the statement of ICANN's "core values" in its most recent strategic plan formulated in November 2004.
"While remaining rooted in the private sector, [ICANN recognises] that governments and public authorities are responsible for public policy and duly [takes] into account governments' or public authorities' recommendations," says core value Number 11. Reference to the large constituency beyond government and "the private sector", predominantly business, is missing, Shahshahani says.
People in the civil society sector have made a huge contribution to the foundation of the internet, he said, but they risk being submerged under a structure which "sees democracy in a different way", as a matter of voting blocs rather than input by all individuals. ICANN is now "disenfranchising the little guy", Shahshahani says. "I see part of my role as to remind ICANN of its roots."
Shashani sees governments taking a larger role in the affairs of ICANN following the World Summit on the Information Society (WSIS) and the parallel working group on internet governance (WGIG) set up by the UN. A the same time, the controversy over ICANN's granting US company Verisign continued authority over the .com domain had put the focus on the private business constituency, he says.
ICANN is a "multi-stakeholder partnership" and a way must be found of accounting for the needs of all stakeholders.


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S Camshaft
Slack Adjuster
Brake Lining
Brake Shoe
Brake Pad
Brake Drum
Brake Disc
Hub Cap
Brake Chamber
About us
Aimbal Industrial Inc. specializes in truck brake drums, brake rotors, brake shoes, brake pads, brake chambers, slack adjusters, S cams, valves and other brake accessories. Since 1994, Aimbal has been supplying brake parts to the medium and heavy-duty truck and trailer industry with consistent quality for 15 years. Our products are used in a wide range of application for major European trucks. From production to inspection, packing, and labelling, all products we delivered are under the strict control of ISO9000 and TS16949 systems.
Let us know your requirements, and we will take care of the rest.
Address: 2-1010, Tianbao Int'l Mansion, No. 61 Haier Road, Qingdao, 266061, China
Tel: +86-532-55578202 Fax: +86-532-55579636 ńĮæń½ÖÕżćµĪłÕÅĘ'╝Ü


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Clear indicators for stopping antiviral therapy in chronic hepatitis B (CHB) patients are not yet available. Since the level of hepatitis B surface antigen (HBsAg) is correlated with covalently closed circular DNA, the HBsAg titer might be a good indicator of the off-treatment response. This study aimed to determine the relationship between the HBsAg titer and the entecavir (ETV) off-treatment response.
This study analyzed 44 consecutive CHB patients (age, 44.6±11.4 years, mean±SD; men, 63.6%; positive hepatitis B envelope antigen (HBeAg) at baseline, 56.8%; HBV DNA level, 6.8±1.3 log10 IU/mL) treated with ETV for a sufficient duration and in whom treatment was discontinued after HBsAg levels were measured. A virological relapse was defined as an increase in serum HBV DNA level of >2000 IU/mL, and a clinical relapse was defined as a virological relapse with a biochemical flare, defined as an increase in the serum alanine aminotransferase level of >2 × upper limit of normal.
After stopping ETV, virological relapse and clinical relapse were observed in 32 and 24 patients, respectively, during 20.8±19.9 months of follow-up. The cumulative incidence rates of virological relapse were 36.2% and 66.2%, respectively, at 6 and 12 months, and those of clinical relapse were 14.3% and 42.3%. The off-treatment HBsAg level was an independent factor associated with clinical relapse (hazard ratio, 2.251; 95% confidence interval, 1.076–4.706; P=0.031). When patients were grouped according to off-treatment HBsAg levels, clinical relapse did not occur in patients with an off-treatment HBsAg level of ≤2 log10 IU/mL (n=5), while the incidence rates of clinical relapse at 12 months after off-treatment were 28.4% and 55.7% in patients with off-treatment HBsAg levels of >2 and ≤3 log10 IU/mL (n=11) and >3 log10 IU/mL (n=28), respectively.
Chronic hepatitis B (CHB) is the leading cause of liver cirrhosis and hepatocellular carcinoma (HCC) worldwide, especially in Asia [1]. Since the replication of the hepatitis B virus (HBV) and the subsequent immune response are the main mechanisms by which chronic intrahepatic necroinflammation, progressive fibrosis, and liver cirrhosis develop, most practice guidelines recommend achieving long-term suppression of viral replication in CHB patients [2-4].
With the development of effective oral nucleos(t)ide analogues (NAs), prognosis of patients with CHB has improved significantly. NAs with a high potency and high genetic barrier, such as entecavir (ETV) or tenofovir disoproxil fumarate, effectively suppress HBV replication and hepatic necroinflammation, and they prevent disease progression and the development of complications [5-8]. However, the optimal duration of treatment is not clearly defined. The Western practice guidelines recommend long-term maintenance of NA treatment until the patient achieves hepatitis B surface antigen (HBsAg) seroclearance [2,9]. Considering the low incidence of HBsAg seroclearance following NA treatment [10-12] and the high relapse rate following the discontinuation of NA without HBsAg seroclearance [13-16], long-term treatment with NA is required in most CHB patients.
Recent studies have identified predictors of sustained off-treatment response following NA cessation, such as younger age [17,18], low alanine aminotransferase (ALT) [19] and HBV DNA [20] levels at baseline, and the duration of consolidation treatment [21-25]. Discrepant predictive values have been noted among various studies depending on the type of NA used, the criteria for the discontinuation of treatment, and the definition of relapse. In addition, the Asian Pacific Association for the Study of the Liver (APASL) recommends the discontinuation of NAs at 12 months of consolidation treatment after hepatitis B envelope antigen (HBeAg) seroconversion in HBeAg-positive patients, and at 12 months of consolidation treatment after achieving undetectable HBV DNA in HBeAg-negative patients [3]. However, CHB relapse occurs in most patients even though treatment is discontinued in accordance with this recommendation [23,24].
The serum HBsAg level correlates with the level of intrahepatic covalently closed circular DNA [26,27]. Furthermore, over the natural history of CHB, a low serum HBsAg level has been associated with improved immune-mediated viral clearance [28,29]. Therefore, serum HBsAg level could be a good predictor of sustained off-treatment response after NA cessation. Several studies have evaluated the efficacy of serum HBsAg level for predicting sustained responses following NA cessationbut the results have been conflicting so far. While some studies have validated serum HBsAg level as a predictor for sustained response [30-34], others have failed to demonstrate a relationship between serum HBsAg level and sustained off-treatment response [20,35,36]. Therefore, this study aimed to evaluate the efficacy of using the serum HBsAg level in predicting sustained off-treatment responses in ETV-treated CHB patients.
Consecutive CHB patients who were treated with ETV for a sufficient duration and for whom treatment was thereafter discontinued after measuring serum HBsAg levels were included in this study. Patients with a previous history of treatment with NAs before ETV treatment or patients with HCC at the time of ETV initiation were excluded. CHB was defined as a positive serological test for serum HBsAg for at least 6 months. Virologic response was defined as a decrease in serum HBV DNA to undetectable levels by PCR assays [9]. Sufficient treatment duration was defined as ≥12 months of consolidation treatment after serum HBeAg clearance and virologic response in HBeAg-positive CHB patients and as ≥12 months of consolidation treatment after virologic response in HBeAg-negative CHB patients. Liver cirrhosis was diagnosed based on histology and/or imaging studies. The study protocol conformed to the ethical guidelines of the 1975 Helsinki Declaration and was approved by the Institutional Review Board (No: ED16137). A waiver of consent was obtained and the patient records were anonymized and de-identified prior to analysis.
Data collection
Clinical data including age, sex, daily alcohol consumption amount, and history of diabetes and hypertension were collected for each patient. Results of the laboratory tests (i.e., platelet count, international normalized ratio [INR], serum ALT, bilirubin, albumin, creatinine, and HBV DNA levels, and serum HBeAg/Ab) were collected at the time of ETV initiation. The duration of ETV treatment, the duration of consolidation treatment, the time of virological relapse, and the time of clinical relapse were also collected. The serum HBsAg level was measured at the end-of-treatment using the Architect HBsAg QT chemiluminescent microparticle immunoassay (Abbott Laboratories, Abbott Park, IL, USA). Laboratory tests, including serum HBV DNA and ALT levels, were performed for all patients every 3-6 months after the end-of-treatment. Patients were evaluated more often when clinically indicated. Virological relapse was defined as an increase in the serum HBV DNA level >2000 IU/mL, while clinical relapse was defined as a serum ALT level elevation >2 × upper limit of normal in addition to HBV DNA level >2000 IU/mL [20].
Statistical analyses were performed using SPSS software version 20.0 (SPSS Inc., Chicago, IL, USA). Data were expressed as the mean±standard deviation or number (%). The Mann-Whitney U test and chi-square test were used to compare continuous and categorical variables, respectively. The cumulative virological relapse rate was determined by the Kaplan-Meier method, and the difference between groups was determined by the log lank test. The Cox proportion hazard model was utilized to analyze factors associated with relapse. Significant factors (P<0.1) in the univariate analysis were subjected to multivariate analysis to determine independent predictive factors. All tests were two-tailed, and P-values <0.05 were considered statistically significant.
Baseline characteristics
Baseline characteristics are presented in Table 1. A total of 44 CHB patients were included in this study. The study population had a mean age of 44.6±11.4 years and 28 patients (63.6%) were men. Liver cirrhosis was diagnosed in 17 patients (38.6%). At the time of treatment initiation, serum HBeAg was positive in 25 patients (56.8%) and the mean serum HBV DNA level was 6.8±1.3 log10 IU/mL. Furthermore, the serum HBV DNA level was <7 log10 IU/mL in 22 patients (50.0%), while it was ≥7 log10 IU/mL in 22 patients (50.0%). The serum HBV DNA level was significantly higher in HBeAg-positive patients than in HBeAg-negative patients (7.2±1.0 vs. 6.2±1.5 log10 IU/mL, P=0.011), while other characteristics did not differ significantly between the two groups.
On-treatment virological response
Serum HBV DNA became undetectable in all enrolled patients and the mean time to undetectable HBV DNA was 5.4±0.4 months (median, 5.5 months). Serum HBV DNA became undetectable within 3 months, 3-6 months, and >6 months in 14 (31.8%), 24 (43.4%), and 6 (13.6%) patients, respectively. The time to undetectable HBV DNA did not differ between HBeAg-positive and HBeAg-negative CHB patients (P=0.222).
Serum HBeAg was cleared in all HBeAg-positive patients and the mean time to HBeAg clearance was 13.6±2.7 months (median, 9.8 months). HBeAg seroconversion was achieved in 7 of the 25 HBeAg-positive patients and the mean time to HBeAg seroconversion was 57.9±6.6 months.
Clinical course after the end-of-treatment
ETV was discontinued after 34.7±19.0 months of treatment (37.0±20.2 months and 31.6±17.4 months in HBeAg-positive and HBeAg-negative patients, respectively; P=0.356). ETV was continued for 29.3±18.6 months after undetectable HBV DNA in all enrolled patients (31.0±19.5 months and 27.1±17.7 months in HBeAg-positive and HBeAg-negative patients, respectively; P=0.50) and for 23.4±16.1 months after HBeAg clearance in HBeAg-positive patients. The duration of consolidation treatment was 25.0±16.7 months, which did not differ between the HBeAg-positive and HBeAg-negative patients (23.4±16.1 months vs. 27.1±17.7 months, P=0.475).
Serum HBsAg level at the end-of-treatment was 3.0±1.0 log10 IU/mL. Serum HBsAg levelswere ≤2, >2 ≤3, and > 3 log10 IU/mL in 5 (11.4%), 11 (25.0%), and 28 (63.6%) patients, respectively. The proportion of patients with an end-of-treatment HBsAg level of >3 log10 IU/mL was significantly higher in patients with positive HBeAg at baseline (20 of 25 patients, 80.0%) compared with those with negative HBeAg at baseline (8 of 19 patients, 42.1%; P=0.010). In addition, the proportion of patients with an end-of-treatment HBsAg level of >3 log10 IU/mL was significantly higher in patients with baseline HBV DNA >7 log10 IU/mL (19 of 22 patients, 86.4%) compared to those with baseline HBV DNA ≤7 log10 IU/mL (9 of 22 patients, 40.9%; P=0.004).
During a follow-up period of 20.8±19.9 months after the end-of-treatment, virological relapse was observed in 32 patients (20 and 12 patients whose baseline HBeAg was positive and negative, respectively). The cumulative virological relapse rates at 6, 12, and 24 months were 36.2%, 66.2%, and 77.3%, respectively (Fig. 1A). Clinical relapse was observed in 24 patients (16 HBeAg-positive patients and 8 HBeAg-negative patients). The cumulative clinical relapse rates at 6, 12, and 24 months were 14.3%, 42.3%, and 58.5%, respectively (Fig. 1B).
Clinical relapse occurred more frequently in the HBeAg-positive patients compared to the HBeAg-negative patients (P=0.049; Fig. 2A). The cumulative clinical relapse rates at 6, 12, and 24 months were 16.7%, 57.9%, and 73.7%, respectively, in the HBeAg-positive patients and 11.1%, 23.0%, and 37.7%, respectively, in the HBeAg-negative patients. The incidence of clinical relapse differed significantly according to the serum HBV DNA levels at the time of ETV initiation (P=0.038; Fig. 2B). The cumulative incidence of clinical relapse rates at 6, 12, and 24 months were 14.3%, 25.4%, and 37.4%, respectively, in patients with a baseline HBV DNA level <7 log10 IU/mL and 14.3%, 57.1%, and 78.6%, respectively, in patients with a baseline HBV DNA level ≥7 log10 IU/mL. Furthermore, the incidence of clinical relapse differed significantly according to the end-of-treatment serum HBsAg levels (P=0.010; Fig. 2C). Clinical relapse did not occur in patients with end-of-treatment HBsAg levels of ≤2 log10 IU/mL, while the incidence rates of clinical relapse at 6, 12, and 24 months after end-of-treatment were 18.2%, 28.4%, and 28.4%, respectively, in patients with end-of-treatment HBsAg levels of >2 and ≤ 3 log10 IU/mL and 15.4%, 55.7%, and 83.4%, respectively, in patients with end-of-treatment HBsAg levels of >3 log10 IU/mL.
Of 24 patients with clinical relapse, ETV therapy was resumed after clinical relapse in all patients except one patient who was lost to follow-up after development of clinical relapse.
Predictive factors for clinical relapse
A univariate analysis revealed a trend of increased clinical relapse risk with positive serum HBeAg (P=0.056) and higher HBV DNA levels (P=0.063), while the serum HBsAg level was significantly associated with the development of clinical relapse (P=0.008; Table 2). Other variables including age, sex, and duration of consolidation treatment were not associated with the development of clinical relapse.
Multivariate analysis indicated that the serum HBsAg level was the only independent predictor of clinical relapse (β, 0.811; hazard ratio (HR], 2.251; 95% CI, 1.076-4.706; P=0.031), while HBeAg (β, 0.583; HR, 1.791; 95% CI, 0.703-4.564; P=0.222) and HBV DNA levels (β, 0.022; HR, 1.022; 95% CI, 0.671-1.557; P=0.920) were not significantly associated with the development of clinical relapse.
Although various studies have evaluated the predictive efficacy of the serum HBsAg level for a sustained off-treatment response, the efficacy is not clearly defined due to discrepant results. While some studies have reported that the serum HBsAg level is a good predictor for sustained response [30-32], other studies have not [20,35,36]. These discrepancies are not surprising since the type of NA used, duration of NA treatment, duration of consolidation treatment, and the definition of relapse differ across these studies [20,30-32,35,36]. We evaluated the predictive efficacy of the end-of-treatment HBsAg level in patients treated for a sufficient duration with ETV and report that the serum HBsAg level is an excellent predictor for sustained off-treatment response. Patients with end-of-treatment serum HBsAg levels of ≤2 log10 IU/mL showed a sustained response after discontinuation of ETV, which is consistent with previous studies [30-32]. Therefore, monitoring the serum HBsAg level may be useful for determining an optimal time for treatment discontinuation in patients who were treated with NAs for a sufficient duration.
There were some discrepancies between previous results and our results regarding significant predictors for sustained off-treatment response. Although the principle reasons for these discrepancies could be the different types of NAs used, different treatment discontinuation criteria, and the definition of relapse among the various studies, additional factors may be involved. First, previous studies have suggested that a younger age is a significant predictor for a sustained response [17,18]; but, we did not find any relationship between age and a sustained response. Although previous studies have shown a significantly lower relapse rate in patients less than 20 years [17] or 25 years of age [18], all enrolled patients in our study were 20 years or older, with only one patient being <25 years old. Furthermore, previous studies also reported that a lower baseline serum HBV DNA level is a significant predictor for sustained response [20,23,24], but the baseline HBV DNA level was not found to be associated with virological relapse in another study [31].
A previous study reported that the cut-off value of the serum HBV DNA level for predicting relapse as 2×105 IU/mL; however, we could not use this cut-off value as only five patients in our study group had a serum HBV DNA level <2×105 IU/mL. We instead used the median HBV DNA level (7 log10 IU/mL) as the cut-off value in our study. Even as the clinical relapse frequency was significantly higher in patients with baseline serum HBV DNA level of ≥7 log10 IU/mL, the baseline serum HBV DNA level was not significantly associated with the development of clinical relapse, as indicated by a multivariate analysis. This could be explained by the results of the end-of-treatment serum HBsAg level according to the baseline HBV DNA level.
Various previous studies have also suggested that a sufficient duration of consolidation treatment is required to achieve a sustained off-treatment response [21-25]. However, the duration of consolidation treatment was not related with a sustained response in this study. This could be due to the definition of sufficient duration of treatment in this study. All patients in this study were treated with ETV for more than 12 months after serum HBeAg clearance and virologic response in HBeAg-positive CHB patients and virologic response in HBeAg-negative patients. Previous studies have reported that prolonging the consolidation of treatment did not additionally improve the relapse rate [20,22,31].
There are discrepancies in the stopping rule used in this study and that of current practice guidelines [2-4]. First, ETV was discontinued in patients with ETV ≥12 months of consolidation treatment after serum HBeAg clearance and a virologic response in HBeAg-positive CHB patients in this study, while current practice guidelines recommend the discontinuation of NA treatment in patients who have achieved an undetectable serum HBV DNA level and, not HBeAg seroclearance, but HBeAg seroconversion in patients with a positive HBeAg at baseline [2-4]. However, HBeAg seroconversion is rare in patients with genotype C CHB compared to those with other genotypes [37]. In addition, in a previous Korean study, both HBeAg seroclearance and seroconversion were appropriate parameters for the discontinuation of NA [21]. Second, ETV was discontinued in patients with ≥12 months of consolidation treatment after virologic response in HBeAg-negative CHB patients in this study, while the APASL guideline recommends considering discontinuation of NAs in patients who have been treated for at least two years and have an undetectable level of HBV DNA [3]. However, this recommendation of duration of consolidation treatment was produced by the opinion of experts, and not by evidence [3]. Furthermore, the duration of the consolidation period was not associated with the development of clinical relapse in this study. Finally, 38.6% of patients included in this study had liver cirrhosis, while several practice guidelines recommend indefinite antiviral treatment in patients with liver cirrhosis because of the risk of hepatic decompensation or mortality after reactivation [2,4]. Although some patients in this study were combined with liver cirrhosis, their liver functions were absolutely normal at the time of end-of-treatment and there was no serious events in these patients. Similar to this study, 14-41% of patients with liver cirrhosis were included in previous studies [20,33,34].
There are several limitations in this study. First, the serum HBsAg level was not measured at the time of NA initiation as the test was not available. Analyses of baseline HBsAg level and its kinetics during treatment would have provided additional information, as a previous study has found a correlation between HBsAg kinetics and sustained off-treatment response in HBeAg-positive patients [30]. Second, this study was performed retrospectively, and although we enrolled all patients who met the inclusion criteria and tried to avoid a selection bias, it may not have not been sufficient. Finally, the sample size in our study was too small to confirm our results and large scale prospective studies are still needed to confirm the predictive efficacy of serum HBsAg level.
In conclusion, the serum HBsAg level at the end-of-treatment was closely related with off-treatment clinical relapse. Furthermore, a serum HBsAg level ≤2 log10 IU/mL is an excellent predictor for sustained off-treatment response in CHB patients who had received ETV for a sufficient duration.
Table 1.
Table 2.
alanine aminotransferase
the Asian Pacific Association for the Study of the Liver
body mass index
chronic hepatitis B
hepatitis B e antigen
hepatitis B surface antigen
hepatitis B virus
hepatocellular carcinoma
international normalized ratio
nucleos(t)ide analogues
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6. Liaw YF, Raptopoulou-Gigi M, Cheinquer H, Sarin SK, Tanwandee T, Leung N, et al. Efficacy and safety of entecavir versus adefovir in chronic hepatitis B patients with hepatic decompensation: a randomized, open-label study. Hepatology 2011;54:91-100.
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10. Marcellin P, Gane E, Buti M, Afdhal N, Sievert W, Jacobson IM, et al. Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study. Lancet 2013;381:468-475.
11. Seto WK, Wong DK, Fung J, Huang FY, Lai CL, Yuen MF. Reduction of hepatitis B surface antigen levels and hepatitis B surface antigen seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy. Hepatology 2013;58:923-931.
12. Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, Chang TT, Kitis G, Rizzetto M, et al. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years. Gastroenterology 2006;131:1743-1751.
13. Song BC, Suh DJ, Lee HC, Chung YH, Lee YS. Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea. Hepatology 2000;32:803-806.
14. Lee CM, Ong GY, Lu SN, Wang JH, Liao CA, Tung HD, et al. Durability of lamivudine-induced HBeAg seroconversion for chronic hepatitis B patients with acute exacerbation. J Hepatol 2002;37:669-674.
15. Ahn SH, Chan HL, Chen PJ, Cheng J, Goenka MK, Hou J, et al. Chronic hepatitis B: whom to treat and for how long? Propositions, challenges, and future directions. Hepatol Int 2010;4:386-395.
16. Van Nunen AB, Hansen BE, Suh DJ, Löhr HF, Chemello L, Fontaine H, et al. Durability of HBeAg seroconversion following antiviral therapy for chronic hepatitis B: relation to type of therapy and pretreatment serum hepatitis B virus DNA and alanine aminotransferase. Gut 2003;52:420-424.
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19. Patwardhan VR, Sengupta N, Bonder A, Lau D, Afdhal NH. Treatment cessation in noncirrhotic, e-antigen negative chronic hepatitis B is safe and effective following prolonged anti-viral suppression with nucleosides/nucleotides. Aliment Pharmacol Ther 2014;40:804-810.
20. Jeng WJ, Sheen IS, Chen YC, Hsu CW, Chien RN, Chu CM, et al. Off-therapy durability of response to entecavir therapy in hepatitis B e antigen-negative chronic hepatitis B patients. Hepatology 2013;58:1888-1896.
21. Lee HW, Lee HJ, Hwang JS, Sohn JH, Jang JY, Han KJ, et al. Lamivudine maintenance beyond one year after HBeAg seroconversion is a major factor for sustained virologic response in HBeAg-positive chronic hepatitis B. Hepatology 2010;51:415-421.
22. Pan X, Zhang K, Yang X, Liang J, Sun H, Li X, et al. Relapse rate and associated-factor of recurrence after stopping NUCs therapy with different prolonged consolidation therapy in HBeAg positive CHB patients. PLoS One 2013;8:e68568.
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24. Fung J, Lai CL, Tanaka Y, Mizokami M, Yuen J, Wong DK, et al. The duration of lamivudine therapy for chronic hepatitis B: cessation vs. continuation of treatment after HBeAg seroconversion. Am J Gastroenterol 2009;104:1940-1946.
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26. Werle-Lapostolle B, Bowden S, Locarnini S, Wursthorn K, Petersen J, Lau G, et al. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology 2004;126:1750-1758.
27. Chan HL, Wong VW, Tse AM, Tse CH, Chim AM, Chan HY, et al. Serum hepatitis B surface antigen quantitation can reflect hepatitis B virus in the liver and predict treatment response. Clin Gastroenterol Hepatol 2007;5:1462-1468.
28. Chan HL, Wong VW, Wong GL, Tse CH, Chan HY, Sung JJ. A longitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B. Hepatology 2010;52:1232-1241.
29. Brunetto MR, Oliveri F, Colombatto P, Moriconi F, Ciccorossi P, Coco B, et al. Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers. Gastroenterology 2010;139:483-490.
30. Cai W, Xie Q, An B, Wang H, Zhou X, Zhao G, et al. On-treatment serum HBsAg level is predictive of sustained off-treatment virologic response to telbivudine in HBeAg-positive chronic hepatitis B patients. J Clin Virol 2010;48:22-26.
31. Liang Y, Jiang J, Su M, Liu Z, Guo W, Huang X, et al. Predictors of relapse in chronic hepatitis B after discontinuation of anti-viral therapy. Aliment Pharmacol Ther 2011;34:344-352.
32. Chan HL, Wong GL, Chim AM, Chan HY, Chu SH, Wong VW. Prediction of off-treatment response to lamivudine by serum hepatitis B surface antigen quantification in hepatitis B e antigen-negative patients. Antivir Ther 2011;16:1249-1257.
33. Chen CH, Lu SN, Hung CH, Wang JH, Hu TH, Changchien CS, et al. The role of hepatitis B surface antigen quantification in predicting HBsAg loss and HBV relapse after discontinuation of lamivudine treatment. J Hepatol 2014;61:515-522.
34. Chen CH, Hung CH, Hu TH, Wang JH, Lu SN, Su PF, et al. Association Between Level of Hepatitis B Surface Antigen and Relapse After Entecavir Therapy for Chronic Hepatitis B Virus Infection. Clin Gastroenterol Hepatol 2015;13:1984-1992.
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37. Chu CM, Liaw YF. Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: a longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline. J Hepatol 2005;43:411-417.


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From the Boxley Valley Baptist Church, we drove onwards towards Hawksbill Crag. My Aunt was driving down to meet us at the trailhead, so we drove off to get there in time. The drive up to Hawksbill Crag is interesting, to say the least. To get there from Boxley Valley, you turn off onto a dirt road called Cave Mountain Drive. The road runs alongside the Buffalo River, but then steeply runs up Cave Mountain.
And I do mean steep, the road heads up at a crazy angle before finally leveling out at the top of the mountain. Along the way we passed a group of birdwatchers who had randomly stopped their cars in the middle of this narrow dirt road, and a large group of them were standing in the road. We slowly drove by as they gave us weird looks, offended that we would dare drive down the road.
After six miles of bumpy dirt roads, we finally made it to the Hawksbill Crag trailhead. I was amazed that there weren't any other cars parked there already. This is a popular trail, and I've never seen this parking lot empty before.
My Aunt soon drove up and we started on the hike. The trail is short, just 3 miles round trip to the crag and back. The woods here were damaged in the ice storm a few months ago, and there were several fallen trees along the trail. But this is such a popular trail that there were already well-worn detours around the downed trees.
The trail heads down a hill, and then crosses a creek with a small waterfall on it. Then the trail runs alongside the bluffs, providing some great views of the Ozark Mountains.
Eventually the trail reaches Hawksbill Crag, a sandstone rock outcrop that juts out 100 feet above the Whitaker Creek drainage below.
One example of the damage from the ice storm was this pine tree, which fell and dangled precariously over the bluff.
I was amazed that we were the only people out there. This is a popular trail, and I've never been here without seeing other people out on the crag. It was odd to be here without anyone else around.
Hawksbill Crag is said to be the most photographed natural feature in Arkansas. But I have to call shenanigans on that claim. There are a few other places that are bound to have more photos taken of it, like Pinnacle Mountain or Cedar Falls at Petit Jean Mountain. Hawksbill Crag is a beautiful spot, but Pinnacle Mountain and Petit Jean Mountain are much easier to get to. But that morning at Hawksbill Crag, there wasn't anyone out there keeping tabs on how many pictures we took.
We had spent a few hours out there, and I was still amazed that we hadn't seen anyone else hiking out to the crag.
This is the view of a small point on the other side of Hawksbill Crag. That gap in the rocks on top of the bluff is big enough that you can stand between them (I did).
We stood on the crag, looking at the Ozark Mountains spreading out before us. It is an amazing spot, and with an awesome view! We packed everything up and headed back to the trailhead. We soon began seeing people, large groups of them heading to the crag. I was glad that we got there early enough to have all of Hawksbill Crag to ourselves.
Wednesday, June 10, 2009
Hawksbill Crag
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Find it! It will help you make the required discloses when you sell your home. The seller's disclosure you complete will be incorporated into the purchase and sales contract you execute with the buyer. You can't overdisclose-which is why it's helpful to find the one you have in your original house purchase files. It will also refresh your memory on what you need to disclose when you sell. More on that tomorrow!
Do You Have Your Seller's Disclosure From When You Purchased Your Home?
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text: Free Transparent Plastic Cup Mockup Free Transparent Plastic Cup Mockup helps you to present your design. Very simple edit with smart layers. Free for personal and commercial use. Enjoy!Don't forget to share with your friends! AdvertisingAdvertising AdvertisingMore free mockups: Hand Holding Coffee Cup Mockup Soda Cup Mockup Breakfast Mockup with Cup Paper Coffee Cup Cup Mock up Paper Hot Coffee Cup Tableware Mockup Paper Coffee Cup Mockup PSD


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This article first appeared on DUSA Media.
Members of Dundee University's highest governing body started the academic year with a £4,500 weekend retreat at a four-star Hilton hotel, DUSA Media has learned. 19 of the University Court's 23 members, along with various University officials, attended the two-day getaway. Among them was Iain MacKinnon, president of Dundee University Students' Association.
According to the University's policy officer for corporate governance, Dr Christine Milburn, the total cost of the retreat was £4,507.50, excluding transportation expenses. She estimated that the latter would be "a few hundred pounds at most."
The Court met on 5 and 6 September at Dunkeld House in Perthshire. Located "in 280 acres of picturesque Scottish countryside," the hotel offers "luxury accommodation," a health club and a spa, according to its website. It was chosen for its cost-value ratio, location, facilities, availability and flexibility, Dr Milburn said. Alternative venues would have cost between £4,100 to £7,500, she said.
In emails to DUSA Media, Court members defended the retreat. Dr Milburn denied that student fees paid for the weekend. Such a claim would be "misleading," she said, because the Court's budget is part of the University administration's, which in turn is paid for by College contributions based on the University's total income. According to figures provided by Dr Milburn, tuition fees accounted for 17 percent of the University's income in 2011-12.
DUSA president Iain MacKinnon said that by being away from campus, Court members "are removed from routine distractions so that uncluttered thinking can prevail, especially when working in smaller groups."
The rector's assessor, Bernadette Malone, made a similar point. The retreat gave the Court a chance "to discuss and explore in detail ways to enhance the quality of the learning experience for students" and other issues, "all of which benefit students and staff," she said. The assessor represents actor Brian Cox, who students re-elected as rector last year, on the Court.
The Court, an institution unknown to many students, oversees the employment of staff and manages and administers the University's properties and finances. Its obscurity, Mr MacKinnon said, was an "underlying issue here – so few students are aware of what Court actually does that when they see money being spent on it they understandably want to know what they, as students, get from this."
University secretary Dr Jim McGeorge said that more could be done to make the Court's work more transparent. He said that the retreat was particularly useful for those members who are neither University staff nor students and are not compensated for their time. For them, the "retreat provides concentrated time to get to know the other Court members, build effective relationships that are beneficial for the governance of the institution, and … provides dedicated time to really understand and discuss difficult issues."
According to Dr McGeorge, it was the Court's first residential retreat in 12 years. Both he and Ms Malone said such getaways were not unique to Dundee University.
Six senior University officials, among them Dr Milburn in her capacity as clerk to the Court, joined the retreat for the entire weekend. Nine other University representatives only attended meetings held on Sunday.
Standard disclosure: DUSA Media is part of DUSA. But you already knew that.


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House For Cash North Druid Hills, GA
How To Get Rid Of My House in North Druid Hills, Georgia
South Georgia Property Investors http://www.SFREIA.com Contact: Costs Giberson [email protected] Telephone: (561) 305-0505 When: Second Thursday of monthly, 6:30 pm Where: Boca/Deerfield Hilton at I-95 & North Druid Hills
Who Buys Houses For Cash North Druid Hills GeorgiaWho else is lying to us about house for cash North Druid Hills?
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Want To Sell My Home North Druid Hills Georgia
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Recognizing The Home Loan Refine Ask the settlement representative for duplicates of all the documents you'll sign before closing, so you could very carefully evaluate them at your recreation. You'll be placing your John Hancock on several items, including the HUD-1 negotiation declaration, which details every one of the costs associated with the residence sale; the Final Truth-in-Lending Act statement, which lays out the cost of the passion and the lending rate; as well as your final home mortgage paperwork.
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North Druid Hills Property Investors United (TREIU) http://www.treiu.com Call: Noelle Miles [email protected] Telephone: (520) 940-5488 When: 3rd Thursday of every month, 6:30 pm to 9:00 pm Where: ASBA 4811 E. Give Rd., North Druid Hills.
Youre purchasing a future income stream or capital when you buy a financial investment property. Just what you spend for a residential property and the cash money flow it produces makes a considerable distinction in the success of your investment. The trick is identifying which buildings vendors have under-priced.
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Other articles that may be of interest to you:
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All Tti News
Watch Tti's Summer Social Programme Video!
Ever wondered what social life you'll have as a student at Tti School? Watch this video for a taste!
Cambridge Advanced student diary
Read our Cambridge Advanced students weekly diary of their CAE course at Tti School!
FCE Winter Class 2015 are Tti Schools STUDENTS of the MOMENT!
We are pleased to announce that Tti's FCE Winter Class 2015 are Tti Schools STUDENTS of the MOMENT!
Lucy Edmiston - our new Director of Studies
We're so pleased to announce that Lucy Edmiston is our new Director of Studies! Come to the office and say hello!
Two more Tti teachers attain DELTA!
We are pleased to announce that in 2014 two Tti teachers, Sam and John, received their DELTA certificate, the highest qualification in English Language teaching in the UK. Big congrats to Sam & John!
News in detail
Top 10 things to do in London - check out our Blog!
Our current Student of the Moment , Ayaka, has given us her top 10 things to do in London! She's been here for a few months now and has a lot of great tips! At Tti, we choose a student who encompasses what we call the Tti spirit! Ayaka has progressed so much during her time here at Tti and it has been such a pleasure to have her studying with us here in Camden! Here's her London top ten! Enjoy!


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The era of standalone virtual-reality headsets is officially upon us! Oculus Go is the missing link between the high-end expensive VR headsets and the low-end mobile VR platforms. Oculus Go introduces the high-quality wireless VR experience, while also eliminating the necessity of having a beast PC in order to enjoy the virtual-reality to the fullest.
The phrase "standalone VR headset" might lead you to think that you won't really need any accessories for Oculus Go. However, there are a few Oculus Go accessories which make day to day user's experience even better.
1. VR Cover
Oculus Go is already making a name for itself in the field of VR technology and is known for being the most comfortable headset on the market today.
But why not step it up a notch or two?
Take your experience to another level with this custom interface and foam replacement set. The interface is made in such a way to make it possible that you can attach and remove foam replacements with ease so that you can ensure that is better suits your face.
If you have used Oculus Go for an intense gaming (or VR adult experience wink, wink), you can agree that having a cover that will ensure that you don't sweat too much is a lifesaver.
The material is a high-quality PU leather for the outer surface and is especially soft on the skin and easy to wipe in between sessions with antibacterial wipes.
2. Anker Powercore 20100mAh Battery
The battery which the Oculus Go contains is a single 2600mAh battery, which can offer up to about two / two and a half hours of playtime. Charging time to battery life ratio is one of the few known issues of the Go. The Anker Powercore 20100mAh battery is a power supply containing six 3400mAh cells. Battery packs like this can often be found powering laptops. The Anker Powercore is connected to the Oculus Go via a USB port.
Two hours of watching time are not nearly enough for most people. You don't want to be interrupted while browsing through the kink section of the Internet. You find your preference and then are interrupted in the middle of the action (*cough, cough*) by the powering off Oculus Go.
Not fun at all.
If you are thinking about getting only one of the Oculus Go accessories from this list, this is probably the most essential of them all. This battery pack charges your standalone headset, keeping it topped up to 100% for an additional 14 hours. Combined with 2 hours that the battery incorporated in the headset provides, this adds up to 16 hours of straight games or movies! With these battery pack, you can rest assured that you will not be interrupted.
Check out Anker Powercore 20100mAh Battery on Amazon
3. Xbox One S Wireless Controller
To get the best out of some games and apps available for Oculus Go, you are going to need a controller different from the one which comes in the box. You want to make sure you get the right one, so have in mind that the original Xbox One Controller doesn't work, as it doesn't have Bluetooth. This is also the case with Xbox One Elite controller.
The grey Xbox One S Wireless controller, as seen in the image above, matches your Oculus Go perfectly. It looks almost as if it was made specifically just for the Go! The controller works best with games and apps such as KIN, BlazeRush, Oculus Arcade and many more.
Check out Xbox One S Wireless Controller on Amazon
4. HermitShell Hard Travel Case (medium)
One of the main advantages of Oculus Go is that it needs no cables whatsoever. This makes it viable for use on-the-go and quite practical if you travel a lot and want to carry your VR platform around with you.
You can fit all of the aforementioned Oculus Go accessories inside the hard travel case made by HermitShell (originally made for GearVR), along with the headset itself. It will ensure that your tech pieces remain undamaged during normal travel conditions. It is more than capable of taking a few hits!
The material lining clip inside the case keeps everything strapped down in place. The travel case also has the little net accessory compartment, however, you probably won't get to use it, since there will be little to none space left inside this compact case once you've fitted everything inside.
This hard travel case isn't completely waterproof but is water resistant to some extent. This means that if you get caught in a rain shower, your Oculus Go accessories will remain dry and undamaged.
Check out HermitShell Hard Travel Case on Amazon
5. Oculus Go Stand
The hard travel case can be used as the storage case as well, however, if you want to put it on a display, this universal VR stand is the right choice for you! The stand is made out of premium ABS plastic, stable and sturdy with a large round base.Check out Oculus Go Stand on Amazon
6. Micro USB Magnetic Cable for Oculus Go
As we already pointed out, the charge time to playtime ratio of Oculus Go isn't as optimal. Therefore you are going to spend a lot of time charging it via the micro USB connector. If you aren't familiar with these USB magnetic cables, these are invented by Apple way back, and you can usually find them on Mac laptops.
Micro USB magnetic cable is an alternative which will keep your Oculus Go charged and ensure it won't topple over if you trip over the cable. While this Oculus Go accessory isn't really a necessity, a micro USB magnetic cable is a neat product to have, both in terms of aesthetics, but also on the side of safety. It can also be used to charge other apple products.
Check out Micro USB Magnetic Cable for Oculus Go on Amazon
7. RAVPower FileHub Plus – video streaming device for Oculus Go
Now this piece of hardware is absolutely essential, essential I tell you if you wish to download and watch videos offline.
Since the Oculus Go only comes in 32GB and 64GB versions, downloading videos in high definition will quickly fill up the internal memory.
If you use Oculus Go for the purpose that it was made to do (porn, I tell ya), after a day or two of browsing through the websites and downloading the content you like, you will quickly max out the memory.
Have no worries, amigos, for I bring solutions to thee troubles.
Simply buy RAVPower off of Amazon and check out the section for watching videos offline in our article for the easiest way to watch adult videos on Oculus Go.


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MOSCOW, April 14. /TASS/. The Collective Security Treaty Organization (CSTO), a post-Soviet security bloc, is convening an emergency meeting of its Permanent Council over the situation in and around Syria on April 14, the CSTO press service reported on Saturday.
- OPCW experts to continue work in Syria
- US, its allies fire over 100 missiles against Syria — Russian Defense Ministry
- Russian top brass names Syrian air defense complexes that thwarted attack
- Diplomat: Strikes against Syria come right when country got a chance for peace
- Russia's ambassador to US comments on strikes against Syria
- US Department of State mum on whether Russia was notified of Syria operation in advance
"The Collective Security Treaty Organization is convening an emergency meeting of its Permanent Council over the situation around Syria at Russia's initiative today. CSTO Secretary General Yuri Khachaturov will take part in the meeting," the press service reported.
Strike on Syria
According to the Russian Defense Ministry, the missile strike against Syria's military and civilian infrastructures was carried out by US warplanes and naval ships in cooperation with the British and French air forces between 03:42 and 05:10 Moscow time on Saturday.
The ministry reported that a total of 100 cruise and air-to-surface missiles had been fired (while 59 missiles were fired at the Shayrat Airbase last year), most of them were shot down by Syria's air defense units upon approaching their targets.
The United States, the UK and France said the strikes were a response to an alleged chemical weapons attack in Syria's Douma.
A number of non-governmental organizations, including the White Helmets, earlier alleged chemical weapons had been used in Douma, Eastern Ghouta, on April 7. The Russian Foreign Ministry dismissed these reports as fake news. Moreover, the Russian Defense Ministry pointed out that the White Helmets are notorious for spreading falsified information.
On April 9, officers from the Russian Center for Reconciliation of the Opposing Parties in Syria visited Douma but found no trace of chemical weapons there.
Experts from the Organization for the Prohibition of Chemical Weapons (OPCW) were to begin work there on Saturday.


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Welcome to the Honourable Senator Mohamed-Iqbal Ravalia
Hon. Larry W. Smith (Leader of the Opposition): Honourable senators, I would also like to offer some words to welcome our new colleague in the Senate of Canada, the Honourable Senator Mohamed-Iqbal Ravalia.
On behalf of all Conservative senators, I extend congratulations to the senator on his recent appointment. We send our best wishes to the senator and his family as they begin this new chapter of their lives here today.
Conservative senators want to get to know their new colleague. They hope he, too, will come to know them and understand the importance of their work as the official opposition in the Senate.
Senator Ravalia will find that our caucus has four senators from his home province of Newfoundland and Labrador: Senators Doyle, Manning, Marshall and Wells, – who are all proud representatives of their province in the Parliament of Canada. And, of course, our Speaker hails from the great province as well.
Honourable senators, it is a great honour to be named to serve in the Senate and to have an important part in shaping the legislation and public policy that impact the daily lives of our fellow citizens from coast to coast to coast.
Senator Ravalia joins us today in the midst of our debate on the legalization of marijuana, one of the biggest policy shifts in decades. I am certain that our colleague will find his work here tremendously interesting as he takes on his new responsibilities.
Welcome, Senator Ravalia.


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The Journey of Obedience
When God calls, our answer is that of Isaiah - "Here I am send me". After many trips to West Africa - specifically to West Africa Theological Seminary - Marybeth and I have felt led to join with World Gospel Mission as Missionary Volunteer Partners. Our first 'assignment' will be at WATS. We begin the Journey of Obedience. - Mark & Marybeth, - Dec 2015
We are thankful to God for you our friends and family. We sense your prayers. We are grateful for your financial gifts.. We are humbled that God would ask us to join Him in the work that He is doing in West Africa and WATS. As we get closer to the date of being at WATS our excitement grows - along with all of the 'what if's'. Continue to pray for us and those at WATS. Continue to be obedient to God as He uses us to be 'His Rivers''. Below are two specific ways to do this: Support Us & Support the Mission..
We are responsible for all of our living expenses while in Nigeria, A monthly gift of $25, $50, $100 or more will be deeply appreciated and will help us meet the need. Would you ask God IF or HOW you might help? All gifts are tax-deductible and 100% of your gift will come to us. By clicking on the button below you can give one-time, monthly, or other ways through World Gospel Mission. Thank You in advance!


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Information About James - Wembley teacher
Profile Picture
Instruments Taught
|Hourly Fee
Music Theory
|Hourly Fee
|Hourly Fee
Music Production
|Hourly Fee
Map Location
Personal Description:
Proffesional musician based in London with over 5 years of studio and live session work as a guitarist. I have been recording and performing in some of London's best known studios and venues over this period. I teach at a private Air conditioned recording studio near Dollis Hill tube station (Jubilee Line), I can also travel to the student's house including travel expenses, however lessons in recording and production techniques can only be done at the studio.
Some of the artists and producers I've worked with include Mark Opitz (ACDC, INXS), Liam Watson (White Stripes), Steve Parsons (Ginger Baker, Sharks), Barry Sage (Rolling Stones, New Order), Saul Ashby, Eden James, Pete Brown (Cream), Rob Bravery, The Lost Society and Eron Falbo.
Tutoring Experience:
Over 4 years teaching experience in Guitar and Music Theory in all styles except Classical and Heavy Metal.
Tutoring Approach:
My expertise lies in helping students get the desired sound and enjoyment out of their guitar. As a working guitarist I also have extensive knowledge of guitars, pedals and amplifiers, and how to get a great sound out of your equiptment.
For beginners, we can work on basic technique, strengthening the fingers, and most importantly learning your favourite songs.
Intermediate level students can look at improving their technique, learning more of the fretboard, looking at improvisational based music, or just getting into some new ways of enjoying the guitar.
Advanced level students can delve into Jazz theory and improvisation, soloing techniques, composition, and fretboard mastery.
For any students wishing to get into playing live or recording, I can take you through audition preperation tips, recording tips and techniques, and whats involved in playing live.
Tutor Resources: (free to download)
Please login or register to download tutor resources.
Availability: Weekends / Weekdays (all times)
References Available: No (✘ Not On File)
- The Academy of Contemporary Music (2010) - Contemporary Music (Bachelors) (✘ Not On File)


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2017 Newsline Young Ham of the Year Award to YACHT member
For the second straight year, the coveted Newsline Young Ham Award went to a YACHT member...
Marty Sullaway KC1CWF #110 of Massachusetts. He is a very active young ham with many awards and accomplishments to his credit. He became a ham in 2014 and today stands as one of the most productive young hams in the country at age 15. YACHT is proud of him and very happy to count him as a member of our premier youth ham group.
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If you love reading books that are very honest, true & not overtly corny regarding relationships, this one is very good.
'Happiness for Two: 75 Secrets for finding more joy together' by Alexandra Stoddard.
With chapters titled:
'Please don't say something you'll regret'
'Eat as many meals together as possible'
'Don't correct each other in public'
'When treats become traps'
'Write love notes'
"When you are together, be together',
they seem simple enough, but I know when I actually stop to consider these points, they take acknowledgement & work. Relationships, no matter how new or mature they are, take a lot of effort, combined respect & shared consideration. In so many other areas in life we are willing to take time to nurture our craft at work, in the kitchen, hobbies & sports (who can walk out onto a T-box, swing their club & land on the green every time? Definitely not me), the list goes on. A partner & love in life is one of the most important relationships you will have. Why not allocate time together to work on it.
I am not saying aspire to be perfect for each other or court every second, but it is easy to become complacent, forget to take the time you did early on to make the other feel special
I picked this book up when browsing Anthropologie (oh…. Polo Park, how you are finally getting better with age) last weekend with a girlfriend & brought it home. Returning to my condo that sunday there was no questions where my guy would be. Stapled to the couch in the living room, phone in hand to constantly review his fantasy draft & glued to the TV for his committed day of 'guys in tights who hurling themselves at each other & dancing hilariously when one get the pigskin past the last line'. I sat down beside him, pulled the book out of its tissue & asked him if he would be willing to read it with me a little each day. Without missing a beat he turned to me & said sure. He didn't even open the cover. That felt great. I have never asked him to read a book with me. He knows I wouldn't ask him if I didn't think it could be something positive & fun.
One chapter is titled 'Write love notes', another 'Bring flowers home'. How many girls have brought their guys flowers or stuffed a note in their wallet or suitcase randomly to be found later? I would bet 9/10 guys would find it as endearing as a girl would being the receiver. Don't let gender stereotypes dictate how to show your love.
We are just getting started on this book, but I have a feeling my favourite chapters will be 6, 21, 28, 46 & 59.
Now, maybe go buy some flowers. Regardless of your partners gender.
Ps. Wheres your favourite place to get flowers?


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When Gutenberg releases to the wild, expected to be sometime in April, 2018, WordPress will become more accessible. While part of that is from the constant improvements being made by the WordPress Accessibility Team, the new Gutenberg editor is bringing in some impressive features that greatly improve the accessibility of content produced using WordPress.
Gutenberg's history with accessibility is…complicated. When the plugin first launched, it wasn't truly ready from an accessibility standpoint. A lot of reviewers jumped on that issue, and rightfully so. Since then, a lot of improvements have been made to Gutenberg's accessibility. But that's not what we're here to talk about.
The trick with accessibility in WordPress content is it relies on the content creator to be aware of accessibility guidelines and standards. WordPress and the Accessibility Team do all they can, but ultimately some things are out of their hands. That's where Gutenberg's new features come in. Here are the top 3 new accessibility features of the Gutenberg editor.
3. Heading Blocks
The advent of the block system is a big shift in the way creators create content in WordPress. The great thing about these blocks is they make your content more accessible by default. One of the new blocks is the Heading block. This block places <h> tags in your content. You're able to select the heading level, from H1 to H6 using the contextual sidebar menu. This may not seem revolutionary, but it is because it is taking the need to markup your content out of the hands of content creators. From an accessibility point of view, it means users are less likely to misuse HTML markup, meaning pages will be more semantic. More semantic markup is very good for accessibility.
2. The Table of Contents
One of my favorite features of Gutenberg is the Table of Contents that has been added both to the editor sidebar and the new info tab. The ToC tracks your heading blocks and builds a dynamic table of contents for you as you write. This feature is incredibly helpful for writers in general, but it has an additional benefit of keeping track of the semantics of your content.
As mentioned previously, semantic content is more accessible. The Table of Contents feature shows you what level headings are, and nests them accordingly. It also tells you when you have an incorrect heading level, highlighting the heading in a dark yellow for added attention. This reinforces the idea of semantic markup, and helps keep uninformed content creators in line.
Beyond semantics, the ToC also gives creators a preview of how screen readers will present content to users. Screen readers often give users a table of contents based on the headings as a way to skip past sections of content. Now creators will be able to see what is being presented to their screen reader users and allow them to structure their documents so that the content stays accessible.
1. Color Contrast Checker
One of the great new features of Gutenberg is the ability to change the background and text colors of individual paragraphs. Accessibility gets brought into the fold in this feature as well with a color contrast checker that happens instantaneously.
This feature gets my top spot because color contrast is one of the easiest ways to make your site more accessible, but until now it required active effort to check it. You had to use one of several online tools available, input colors manually, and then be informed enough to know what the results mean. Gutenberg takes all that way and simply tells you that you may want to pick a new color scheme. By taking the guesswork out of the process and informing the user automatically, WordPress is yet again pushing accessibility forward.
Closing Up
These three features are just the tip of the iceberg when it comes to the improved accessibility of WordPress. The Accessibility Team is working hard day in and day out to make sure Gutenberg and WordPress as a whole are as accessible as possible before launch.
Do you have a favorite accessibility feature in Gutenberg? Let me know in the comments below!


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National Yemen Exclusive
The al-Maraqisha tribes in Abyan governorate demanded that the authorities apprehend the attackers who attempted to assassinate Colonel Ahmed Ali Mitrees, deputy director of political security in Abyan and a member of al-Maraqisha tribe, who survived an improvised explosive device placed in front of his car last weekend.
The statement of the al-Maraqisha, one of the largest tribes in Abyan, also demanded authorities bear responsibility for the frequent attacks to which security officers are exposed. It stated that the tribe is capable of protecting its members, and that authorities have abandoned their responsibilities, and failed to provide security and facilities, adding that Colonel Mitrees had no security guards, nor a security convoy, but traveled in his own car.