text:
See the commentary-article "Combination of synbiotic and sitagliptin in nonalcoholic fatty liver disease: Is it better than sitagliptin alone?" on page 299.
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases in recent years. The aim of this study was to evaluate the effects of sitagliptin with and without a synbiotic supplement in the treatment of patients with NAFLD.
In total, 138 NAFLD patients aged 18-60 years were enrolled in the study. Patients were randomized to one of the following treatments for 16 weeks: Group I (n=68), sitagliptin 50 mg daily plus placebo (one capsule per day) or group II (n=70) sitagliptin 50 mg daily plus synbiotic (one capsule per day). Changes in fasting blood glucose (FBS), liver enzymes, lipid profile, and body mass index were compared between the groups.
The mean change in FBS with sitagliptin-placebo from baseline was -10.47±5.77 mg/dL, and that with sitagliptin-synbiotic was -13.52±4.16 mg/dL. There was a significant difference between the groups (P<0.001). The mean change in cholesterol (Chol) was -8.34±28.83 mg/dL with sitagliptin-placebo and -21.25±15.50 mg/dL with sitagliptinsynbiotic. There was a significant difference between the two groups (P=0.029). The administration of sitagliptin-placebo induced an increase of 6.13±27.04 mg/dL in low density lipoprotein (LDL), whereas sitagliptin-synbiotic induced a decrease of 14.92±15.85 mg/dL in LDL. A significant difference was observed between the two groups (P<0.001). On the other hand, in the sitagliptin-synbiotic group, there was significant improvement in aspartate aminotransferase (AST) level compared to the sitagliptin-placebo group (P=0.018).
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases in the world [1,2]. NAFLD refers to liver steatosis in the absence of other secondary causes of accumulation of fat in the liver. This chronic disease can be limited to simple steatosis, however, when the disease is associated with inflammation, it can progress to non-alcoholic steatohepatitis (NASH). The likelihood of progression of NASH to liver fibrosis, cirrhosis and eventually to hepatocellular carcinoma (HCC) is high [3-6]. The possibility of progression of simple steatosis to NASH, chirosis and HCC within a period of 10 years is 12–40%, 15–25% and 7%, respectively [7].
The prevalence of NAFLD is not precisely obvious, due to the absence of simple and non-invasive ways of diagnosing a large number of patients without any complication [8,9]. It is estimated that the worldwide prevalence rate of NAFLD is about 25-45% [10].
The most significant histological finding in non-alcoholic fatty liver disease is the increase in the level of fat in the liver cells. However, NAFLD pathogenesis is not well known presently, but the most familiar pathway is insulin resistance. On the other hand, oxidative stress and inordinate activation of the immune and inflammatory systems of the body are regarded as another pathway in the pathogenesis of NAFLD [11-13]. It seems that the successful control of these main pathways involved in the pathogenesis of NAFLD (insulin resistance and oxidative stress with excessive immune and inflammatory activity), is an imperative step in the treatment of NAFLD. Other non-drug therapies that can be adopted in the treatment of NAFLD include lifestyle modification, weight loss and daily physical activity.
Presently, various treatment options that target each aspect of the NAFLD's pathogenesis have been explored and advocated. One of these therapies involves the use of new anti-diabetic drugs that affect the glucagon-like peptide-1 (GLP-1) pathway. This hormone controls blood glucose by stimulating insulin secretion, thereby increasing the oxidation of fatty acids in the liver and the sensitivity of insulin blood glucose levels. These drugs include analogues of GLP-1 (exenatide, liraglutide) and dipeptidyl peptidase-4 inhibitor (sitagliptin, vildagliptin, saxagliptin). DPP-4 is a membrane peptidase that targets GLP-1 and makes it inactive. The inactivation of GLP-1 induces glomerular intolerance and hepatic steatosis. In addition, as regard the activity of peptidase, DPP-4 is associated with stimulation of the immune system, reduction of extracellular matrix and accumulation of lipids. DPP-4 is expressed in high levels in the liver; and by extension, according to information obtained in recent years; DPP-4 has been discovered to be involved in the progression of many chronic liver diseases, such as hepatitis C, NAFLD, and HCC. DPP-4 inhibitors such as sitagliptin, can enhance steatosis, liver damage, and glucose disorders in NAFLD patients; although, they also play a key role in the inhibition and regulation of the immune system involved in the pathogenesis of NAFLD [14,15].
Additionally, gut dysbiosis is said to be associated with obesity, diabetes, metabolic syndrome and NAFLD through excess energy production, disruption of host energy metabolism, pro-inflammatory signals, and finally, the direct effect of hepatotoxicity of bacterial productions such as ethanol and ammonia. Consequently, changes in the intestinal microbial flora and subsequent inflammatory responses play a significant role in liver diseases, especially NASH and cirrhosis [16-19].
Prebiotics are indigestible carbohydrates that have beneficial effects on the host by creating a suitable environment for the growth of probiotics. Probiotics, which are also regarded as liver microorganisms have beneficial effects on the host when they are utilized in ample quantity by modulating the intestinal microbial flora and regulating the immune system. Today, there are drugs in the market called synbiotic that combine the properties of prebiotics and probiotics. Daily use of prebiotics and probiotics is believed to slow down the progression of NAFLD and forestall further degeneration of the disease owing to their ability to control intestinal flora, intestinal permeability and inflammatory responses [6,9]. It therefore seems that the administration of synbiotics in combination with sitagliptin can be more efficacious in the treatment and management of NAFLD patients considering the potency of their complementary roles. The hypothesis we wished to test was whether sitagliptin with and without a synbiotic supplement would be beneficial in the treatment and management of NAFLD patients.
Patients with NAFLD were recruited for the randomized, double blind trial between September 20, 2015 and August 15, 2017 from the Vali-e-Asr Hospital in Zanjan, Iran. The study was approved by the Ethics Committee of Zanjan Metabolic Diseases Research Center (ZMDRC), Zanjan University of Medical Sciences (approval number: A-12-500-13).
NAFLD patients between the ages of 18 and 60 years, with body mass index (BMI) ranging from 25 to 29.9 kg/m2 and who had impaired fasting blood glucose (FBS) (100–125 mg/dL) and/or impaired oral glucose tolerance test (140–199 mg/dL), were screened initially by physical examination and study of their medical history. All patients provided written informed consent to participate in the study. In our study, all the patients were new cases of NAFLD. The diagnosis of NAFLD was made on the basis of the presence of steatosis, on ultrasound examination, associated with elevated alanine aminotransferase (ALT) concentration 1.5–3 times higher than normal upper limit according to sex and age. Those with any history of alcohol consumption more than 10 grams per day in women and more than 20 grams per day in men, respectively were excluded from the study. Exclusion of other liver diseases was made by detailed investigations including hepatitis B and C serology (measured by ELISA with Stat Fax Elisa Reader®), positive antinuclear antibodies or antimitochondrial antibodies (measured by ELISA with Stat Fax Elisa Reader®; Awareness Technology Inc., Palm City, FL, USA), iron profile studies (measured by Kontron GABA Counter®; Roche Bioelectronique Kontron, Paris, France), total iron-binding capacity (measured by BT-3500 AutoAnalyzer®; Biotecnica Instruments, Via Licenza, Rome, Italy), transferrin saturation (measured by BT-3500 AutoAnalyzer®) and positive ceroplasmin (measured by Elisa with Stat Fax Elisa Reader®). Other exclusion criteria included presence of kidney disease, thyroid disorders, immunodeficiency diseases, receiving cholesterol lowering medication, current or previous heart failure and being pregnant or breastfeeding.
Study design
The sample size was computed based on primary information obtained from the study conducted by Wong et al., on ALT [20]. Considering α=0.05 and a power of 80%, the sample size was computed as 66.17 (≈ 67) per group. This number was increased to 70 per group to accommodate the anticipated dropout rate.
Participants were randomly selected into 2 groups using a block randomization technique of size 4.
Patients were assigned in a 1:1 ratio to one of the 2 groups for 16 weeks of treatment, either (1) sitagliptin (50 mg once daily) and placebo (maltodexterin) (once daily), or (2) sitagliptin (50 mg once daily) and synbiotic (500 mg once daily).
At enrollment, the NAFLD patients were advised by a dietitian on the need for energy balanced diet and physical activity according to the "Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults" from the NIH and the North American Association for the Study of Obesity [21].
In group 1, the treatment commenced with one tablet of sitagliptin per day (50 mg/daily) and one capsule of placebo (maltodexterin) per day. In group 2, the treatment started with one tablet of sitagliptin per day (50 mg/daily) and one capsule of synbiotic per day (500 mg/daily). Each synbiotic capsule (Familakt) contained 109 colony forming unit (CFU) of 7 strains of friendly bacteria (Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus acidophilus, Lactobacillus bulgaricus, Bifidobacterium breve, Bifidobacterium longum, Streptococcus thermophilus) and prebiotic (fructooligosaccharide) and probiotic cultures (magnesium stearate [source: mineral and vegetable] and a vegetable capsule [hydroxypropyl methylcellulose]).
Paraclinical assessments
The weight and height (anthropometric measurements) of all the patients included in the study were measured at baseline. The weight of the patients was remeasured at week 16. Each individual's BMI before and after treatment was computed using the following formula: BMI=weight (in kg)/height (in m2). In this study, a precision weighing scale with a precision of 0.5 kg, and which was calibrated everyday was employed. To measure the height, the tape meter with a precision of 0.5 cm was used.
Clinical assessments
Serum levels of FBS, ALT, aspartate aminotransferase (AST), cholesterol (Chol), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) were measured at 0 and 16 weeks. All biochemical assessments were carried out in the same laboratory (central laboratory of Vali-e-Asr Hospital) employing standard laboratory techniques. The biochemical assessments were performed on blood collected after overnight fasting (at least 12 hours).
Adherence to treatment protocol
To ensure that patients adhere to diet and medication regimen, each week a trained person reminds the patients of the necessity and importance of adherence to their treatment regimen through telephone calls.
At the beginning of the study, each patient was informed about the possible side effects of the medications, and advised not to dismiss the researcher and report to the hospital as soon as possible if they had any complications. The phone number of one of the researchers was also made available to patients.
Statistical analysis
Data were analyzed employing SPSS software, version 24 (IBM Corp., Armonk, NY, USA) and results were expressed as mean±standard deviation or percentage. For all analyses, a P-value<0.05 was considered statistically significant. The normality of the distribution of variables was investigated by the Kolmogorov-Smirnov test. Chi-square test was used to compare the qualitative variables. Independent t-test was employed to compare the median of quantitative variables between the two groups. Paired t-test was used to compare the median of quantitative variables before and after treatment in each group. Logistic analysis was used to identify any difference between the two groups after intervention, in terms of lipid profile.
From September 2015 to August 2017, 140 patients were enrolled in the study and randomly assigned into two groups: sitagliptin-placebo group (group 1) (n=70) and sitagliptin-synbiotic group (group 2) (n=70). Sixty-eight patients in the first group and all the patients in the second group completed the study. Patient screening, enrollment, and retention in treatment group are presented in Fig. 1.
In this study, 39.5% of the participants were female and 60.5% were male. In the first group, 44.1% were female and 55.9% were male while in the second group, 35.7% were female and 64.3% were male. There was no significant difference between the two groups (P-value=0.338). The baseline clinical and demographic data of the two groups are summarized in Table 1. As shown in the table, there was no significant difference between the two treatment groups in terms of basic characteristics.
At the end of the 16-week treatment period, a significant improvement in liver enzymes was observed in both groups before and after treatment. In comparison with the sitagliptin-placebo group, patients taking sitagliptin-synbiotic had a significantly higher decrease in AST: we reported the amounts of ALT and AST before and after intervention seperately. ALT (71.60±21.27 to 46.42±17.39 in the sitagliptin-placebo group and 72.00±15.60 to 48.71±13.65 in the sitagliptin-synbiotic group; P<0.456), and AST (51.59±26.89 to 37.30±18.82 in the sitagliptin-placebo group and 54.15±9.89 to 35.00±7.89 in the sitagliptin-synbiotic group; P<0.018) (Table 2-4).
The two treatment groups had comparable Chol, TG, LDL and HDL at baseline (Table 1). The mean Chol, TG, LDL and HDL levels in the sitagliptin-placebo group increased from 197.72±35.91 to 189.37±33.70 (P=0.13), 229.20±116.03 to 194.10±69.07 (P=0.002), 129.48±28.74 to 135.62±28.89 (P=0.232) and 39.55±4.84 to 40.24±4.18 (P=0.538), respectively (Table 2). In the sitagliptin-synbiotic group, Chol, TG, LDL and HDL levels changed from 205.84±29.29 to 184.58±21.78 (P<0.001), 203.84±47.40 to 177.41±21.78 (P<0.001), 122.45±25.93 to 107.53±19.85 (P<0.001) and 39.75±4.09 to 41.58±2.52 (P<0.001), respectively (Table 3). The difference between the changes observed in the two groups in terms of Chol and LDL was statistically significant (Table 4).
With the use of logistic analysis, it was concluded that the sitagliptin-synbiotic combination therapy was more efficacious than the sitagliptin-placebo composition on blood TG levels in the range of 150 to 200. In addition, this combination therapy showed the highest efficacy in the levels of 130≤ LDL<160 when compared to sitagliptin-placebo combination (Table 5).
FBS also decreased significantly in both groups before and after treatment. The reduction in the sitagliptin-placebo group compared to the sitagliptin-synbiotic group was as follows: FBS decreased as much as -10.47±5.77 compared to -13.52±4.16 (P<0.001).
Additionally, a significant decrease in weight and BMI was observed in both groups (Table 2 and 3); however, no significant difference was observed between the two groups in relation to the aforementioned variables (Table 4).
Adverse events such as peripheral edema, decreased blood sugar, diarrhea, constipation, nausea, spinal osteoarthritis, upper respiratory tract infection occurred in none of the patients in each treatment groups.
Today, various therapies for the treatment of NAFLD have been proposed; however, the relative risk benefits of the different therapies remain one of the most challenging aspects of the treatment and management of NAFLD. Lifestyle changes including dietary habits and participation in regular physical activity are typically part of the standard recommendations [22,23].
To the best our knowledge, this was the first randomized, double-blind clinical trial that evaluated the effects of combination of sitagliptin-synbiotic in comparison with sitagliptin alone on the characteristics of NAFLD.
The present study revealed that the combination of sitagliptinsynbiotic as against sitagliptin alone significantly reduced the levels of FBS in NAFLD patients. Various studies have suggested that Lactobacillus and Bifidobacteria found in synbiotic and probiotic compounds can enhance the levels of FBS [23,24]. The reason for this is that the bacteria present in the synbiotic compounds increase glucose uptake by stimulating the production of insulinotropic polypeptides and glucagon-like peptides (GLPs) by modifying the intestinal microbial flora [25]. On the other hand, sitagliptin is a drug that increases the survival of GLPs especially GLP-1 by inhibiting the enzyme DPP-4 [27-29]. Consequently, these two drugs can further improve blood glucose levels in patients with fatty liver and impaired fasting plasma glucose by reinforcing each other's effects.
To date, only few studies have been conducted on the effects of sitagliptin on lipid profiles. Our study revealed that treatment with sitagliptin for 16 weeks significantly reduced TG levels in the first group. In parallel to our study, Koren et al. [30], in their research on patients with type 2 diabetes mellitus reported that treatment with sitagliptin for 3 months significantly affected the level of TG. However, changes in the total serum Chol, LDL, and HDL levels were not statistically significant. The current study notwithstanding, the effects of sitagliptin on improvement of LDL and Chol have also been reported in some studies. This improvement may be due to strict adherence to diet and exercise regimen and the long duration of the studies [31,32]. How sitagliptin improves lipid profile is not well known, but it is said that gastric inhibitory polypeptide (GIP) can purify the circulating chylomicrons by stimulating the activity of adipose tissue lipoprotein lipase [33,34]. On the other hand, GLP-1 can decrease the secretion of triacylglycerol after meal [35]. Consequently, sitaglipin with its protective effects on GIP and GLP-1 can possibly improve lipids status. Our study demonstrated that when synbiotic is added to sitagliptin, it can enhance lipid profiles further. Recently, some studies on animal models have suggested that the use of synbiotic can lead to improvement in lipids status [36,37]. In addition, some authors have spoken about the positive effects of synbiotics on metabolic syndrome [38]. The positive effects of synbiotics on lipid profiles might be justified by the production of short chain fatty acids, carbon disulfide, methyl acetate, assimilation of Chol in the gastrointestinal tract, enzymatic deconjugation of bile acids and alteration of Chol to form coprostanol in the intestine [24,39]. Logically, the more potent effect of sitagliptin-synbiotic seems to be that the two drugs play complementary roles in the body in terms of improving lipid profiles.
Furthermore, this study had several limitations. One of the limitations of this study was the lack of histopathological confirmation, which could not be done on ethical grounds. Another limitation of this study was the patients' follow-up period. Perhaps the time of follow-up was not enough for some long-term effects such as weight loss.
Generally, the findings of this study are relevant due to the fact that the major risk factors of NAFLD such as obesity, type 2 diabetes, dyslipidemia, and metabolic syndrome are on the increase owing to the industrialization of societies, the mechanization of a lot of daily activities, and lack of exercise and inappropriate diet [40]. The prevalence of NAFLD in the coming decades seems to be much higher than its current status. Additionally, NAFLD patients have elevated blood glucose, lipids, blood pressure, and cardiovascular diseases and life expectancy also decreases in these patients [16,41,42]. Considering the complications, morbidity and mortality resulting from it, it is imperative to pay special attention to the disease. On the other hand, although today, NAFLD's non-pharmacological treatments such as lifestyle modifications, proper diet and increased daily activities are said to be much more efficacious than pharmaceutical treatments; however, due to the failure of patients to adhere to these methods in the long-term, attention to and review of drug therapies is inevitable [17].
Our results show that the combination of sitagliptin-synbiotic as against sitagliptin alone can better improve AST, FBS, Chol, and LDL in NAFLD patients. The benefits reported with administration of synbiotic in this study support the results of larger studies with histological endpoint in patients with NAFLD. Through this method, a reference for choosing the best options for treatment of NAFLD patients can be provided.
Author contributions
Saba Sayari conceived the study, analyzed data, and wrote the manuscript. Hassan Neishaboori and Maryam Jameshorani performed diagnosis, selected patients and collected samples.
Table 1.
Table 2.
Table 3.
Table 4.
Table 5.
alanine aminotransferase
aspartate aminotransferase
body mass index
colony forming unit
dipeptidyl peptidase-4
fasting blood glucose
gastric inhibitory polypeptide
glucagonlike peptide
glucagon-like peptide-1
hepatocellular carcinoma
high density lipoprotein
low density lipoprotein
non-alcoholic fatty liver disease
non-alcoholic steatohepatitis
Zanjan Metabolic Diseases Research Center
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Hi and welcome to the GRFA fishing report updated on the 26th ofAugust 2017.
GRFA proudly hosted the 2017 Jurassic Classic Sturgeon Fundraiser last weekend. Through the efforts of the BC Wildlife Federation and The Wild Sheep Society of BC, this incredible event raises awareness and much needed funding for the plight of the Wild Sheep here in BC. This year's event was a smashing success and not only did we raise a substantial amount of money for a worthwhile cause but the fishing was much better than the previous year… to the tune of a 46% increase over last year with the same amount of boats participating!! Awesome!
Part of the success in this year's fishing was due to this being a Pink salmon year and the river is already seeing lots of them. Sturgeon have definitely switched gears and are actively searching out salmon pieces and roe now. There are some boats still reporting activity on other baits like lamprey and coarse fish but this seems to be a day to day phenomena rather than the norm.
The Fraser River is in prime shape at the moment. Water that was too fast to fish a few weeks ago is starting to slow down and become fishable. Keep in mind that with the dropping water many gravel bars are starting to appear above the mouth Vedder River and one needs to be more careful when running the river, especially with a prop propelled boat.
The Canyon continues to produce both numbers and size. If you are thinking of running this special piece of water keep in mind that is very "heavy" water and not for the timid or inexperienced jet boater. Please be very careful!! The canyon is a high water fishery and the sturgeon haunts are not always obvious as the water levels tend to hide the really good spots. If you're interested in trying your hand at biggest of the big in one of the most spectacular venue's in the world drop Rick a line and he'll be more than happy to help organize one of our Ultimate Fraser Canyon Sturgeon trips with you. firstname.lastname@example.com
What better way is there to spend a warm summer day than sitting in a comfortable covered jet boat waiting on another bite from the almighty sturgeon. With limited fishing pressure on the river this is a great time of year to get out and experience these dinosaurs of the deep. We offer half and full day outing's via jet boat with nothing but the finest in guides and tackle. We pride ourselves in ensuring your day is as comfortable, safe and enjoyable as possible. Whatever your speed, we will cater to your needs. Call or email today.
Currently the Fraser River system and it's tributarie's remain closed to sportfishing for salmon. This is due to the continued decline in Sockeye stocks in both the marine approach and also the Fraser River itself. Summer Sockeye stocks have been downgraded to 1.25 million – not good news for the sport fisher…
Although the river has a healthy number of Pinks in it, especially for this time of year, they are seeing dwindling numbers in the test sets and also in the marine testing….they have given a new interim run size of 3.96 million. This is very early for DFO to be overly accurate with their counts or reports and we should see this number change as the run progresses.
So how does this impact our sport fishery??
The recreational angler will probably not see an opening for Salmon until we see a larger number of Pinks enter the system. The next few weeks will be the telltale how our salmon season will unfold. If numbers bump up we could see an opening as early as the 10th of September. However, if numbers remain low we could see an opening as late as October 10th after the Coho closure window.
Keep in mind that it is unlikely that First Nations will get anywhere close to their food, social and ceremonial required fish from Sockeye – so they will likely fill their quota with Chinook – the DFO is approving these fisheries, however will reduced fishing times each weekend and have written into the license that all attempts must be made to release non target species unharmed (i.e. Sockeye, Steelhead and Sturgeon) and only when all attempts have been made to revive these non-target fish can they be taken – we applaud DFO for showing responsibility to the conservation of the fish in this manner.
We encourage everyone to write letters to ask for a recreational opening. It is a shame that the largest user group, which has the least amount of impact on the fishery and brings the highest dollar value to the fish on a per piece basis, has to sit on the side line while other sectors are given opportunities. These are outdated policies that need to change and without a loud and unified voice we, the recreational angler, will always play second fiddle to political interests. Please write your concerns to:
- Hon Dominic LeBlanc Minister of Fisheries email@example.com
- Hon John Horgan Premier firstname.lastname@example.com
- Doug Donaldson Minister FLNR firstname.lastname@example.com
- Terry Beech DFO Parliamentary Sec. email@example.com
- Todd Doherty Conservative fisheries critic firstname.lastname@example.com
- Rebecca Reid RDG DFO firstname.lastname@example.com
To all of those who have written letters, thank you so very much – the future of our Fraser River fishery depends on each of you and your efforts.


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Halloween Safety
☀ ☀
2. It is best to Trick or Treat in a Shopping Mall, Church Community or HOA Efforts rather than a neighborhood of people you do not know. The rule of thumb is unless you know the people inside the home – avoid.
3. Never approach an unknown home especially if it is not lit up with outside lighting.
4. Do not consume anything from the candy or treats bag. Once returning to your home inspect everything no matter who received from.
5. ENTER SOMEONE'S HOME, VEHICLE or "Into the Woods" to supposedly "see" something.
6. Be very careful if walking the streets. Stay on sidewalk or yard-to-yard if possible.
7. NEVER Trick or Treat alone. I see this year after year, it is disturbing. No matter the age, never go alone. Parents and Guardians, wake up here!
8. DO NOT consume Treats that are "Home Made" unless you know the person(s) well.
9. Adults and Teens out driving on this evening. Drive responsibly, NO speeding, NO alcohol or have someone in charge who is not drinking. Be on the constant look out for others. Remember how excited small children are and could very well dart right into the streets. Be aware for them. Thank You!
10. Have a GOOD Flashlight and illuminated stickers or stripes. Everyone in your "group" should be carrying a light and covered strategically head to toe.
🤹 Ketogenic Lifestyle 🤹 🔮 50 Shades of Sheri 🔮
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Pan seared halibut with a caviar butter sauce, spinach puree and pickled mushrooms
Serves 4.
100ml white wine
1 small shallot sliced
Small sprig of thyme
1 lemon juiced
1 tbsp double cream
200g slightly salted butter diced
1 tbsp olive oil
1 clove of garlic sliced
400g spinach washed
1 tbsp olive oil
2 tbsp butter
4 x 200g halibut steaks
200g wild mushrooms cleaned
1 tbsp cider vinegar
50g caviar
Salt and pepper
1. Place the white wine, shallots, thyme and lemon juice in a small sauce pan over a medium heat, reduce the liquid by half, then strain and discard the shallots and thyme. Poor the liquid back in the pan. Add the cream and put back on a low heat. Slowly whisk in the butter bit by bit until it has all dissolved. Season with salt and pepper and leave in a warm place.
2. Heat the olive oil in a large pan, add the sliced garlic and spinach, and cook until all the spinach has wilted. Remove from the heat and drain.
3. Place the spinach in a food processor until you have a fine puree. Season with salt and pepper and place in a small saucepan, and leave to one side.
4. Season the halibut steaks with salt and pepper.
5. Heat the olive oil and butter in a large non-stick frying pan, when the butter starts to brown add the halibut steaks and cook for 3 to 4 min on each side or until the halibut is just cooked. Remove from the frying pan and keep in a warm place. Reserve the juices in the pan.
6. Put the pan back on the heat, add the mushrooms, cook for a couple of minutes until the mushrooms are just cooked, then add the vinegar and season with salt and pepper and turn off the heat.
7. Gently warm the spinach and the butter sauce, and then add the caviar to the butter sauce. Serve the halibut with the spinach, mushrooms and butter sauce.


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I will be presenting a new talk, Toxic Tech & Tots, around the country in September at the Clicks BabyClub #Meetup events being organised by well-known author and speaker Meg Faure, of Baby Sense fame.
Watch a sneak peak of my Toxic Tech & Tots interview on Expresso Morning Show
These not-to-be-missed parenting events for parents of babies and toddlers feature 16 fabulous speakers who are experts in their fields. We will all be presenting short, punchy talks 15 minutes in length, TEDx style.
These full-day events are divided into four themes and attendees can pick and choose the talks they want to listen to or attend them all:
- Pregnancy Sense
- Baby Sense
- Play Sense
- Parenting Sense
Dates and venues:
- 2 September, The Maslow, Johannesburg
- 9 September, Ratanga Junction, Cape Town
- 23 September, Moses Mabidha, Durban
Cost of tickets:
R185.00 per person
For more information and to purchase a ticket, visit www.babymeetup.co.za
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Silly and Pretty Lame Questions to Irk People Endlessly
Rujuta Borkar
Nov 3, 2018
Silly questions have been there for as long as there have been questions. Period. Want to take a look at some of the best silly questions ever? Read on...
Ah. Silly questions. They irk some, tickle some, humor some, anger some. Silly questions have been here for a really, really long time. You'd think that there's no room for these in an intelligent conversation, but you'd be wrong.
Who says a conversation has to always be only intelligent, meaningful and insightful? It can be silly too. The urge to ignore a silly question as an 'unnecessary diversion/distraction', might be your first instinct.. but if you think back to it, that silly question will actually make you think. So here's to those silly questions then, a tribute, if you must.
Questions that Make You Think
Why is a building called a building when its already built?
Why doesn't McDonald's sell hot-dogs?
Why is it that everyone driving faster than you is considered an idiot and everyone driving slower than you is a moron?
If pro and con are opposites, wouldn't the opposite of progress be congress?
Why does grape flavor smell the way it is when actual grapes don't taste or smell anything like it?
Is it rude for a deaf person to talk (sign) with their mouth full of food?
Do they have the word 'dictionary' in the dictionary?
If a lesbian has sex with other women but never with another man is she still considered a virgin?
Can you dream if you're blind?
When Atheists go to court, do they have to swear on the bible?
What do you do when you see an endangered animal that is eating an endangered plant?
Can animals commit suicide?
How can something be "new" and "improved"? if it's new, what was it improving on?
If laughter is the best medicine, who's the idiot who said they 'died laughing'?
If a bald person works as a chef at a restaurant, do they have to wear a hairnet?
Can a short person 'talk down' to a taller person?
Do prison buses have emergency exits?
Why is it called a funny bone, when if you hit it, it's not funny at all?
Do Chinese people get English sayings tattooed on their bodies?
Why are all the Harry Potter spells in Latin if they're English?
What do Greeks say when they don't understand something?
What do people in China call their good plates?
How would you know when you are out of invisible ink?
After eating, do amphibians need to wait an hour before getting
of the water?
Whose cruel idea was it to put a 'S' in the word 'Lisp'?
Why are cigarettes sold at gas stations where smoking is prohibited?
What is a free gift? Aren't all gifts free?
Questions to Get to Know Someone
In the heat of the moment and the urgency to get to know the other person, we sometimes end up asking really silly questions. See for yourself.
Have you ever imagined a world with no hypothetical situations?
Why do people talk about 'girlie' things but never 'boyie' things?
If you sneezed on a computer, would it get a virus?
Do the Alphabet song and Twinkle, Twinkle Little Star have the same tune?
Why did you just try singing the two songs above?
If Pinocchio said, "My nose is about to grow", is he lying or telling the truth?
Why does your nose run and your feet smell?
If a person suffered from amnesia and then was cured, would they remember that they forgot?
What does OK actually mean?
What came first, the fruit or the color orange?
Can you blow a balloon up under water?
If a person with multiple personalities threatens suicide, is that considered a hostage situation?
If a cow laughed, would milk come out of its nose?
Questions to Ask your Girlfriend
You use these well and they just might get you some brownie points...!
Apart from being sexy, what do you do for a living?
Coffee? Tea? Me?
Are you from Jamaica? 'Coz Jamaica 'n me crazy babe'
What's with all those curves? And me with no brakes.
If love is blind, why is lingerie so popular?
Can I read your T shirt in brail?
I'm addicted to yes, and I'm allergic to no. So what's it gonna be?
Do you have a sunburn, or are you always this hot?
You say 'I bet you $20 I can kiss you without using my lips.' She says, 'Bet's on.' You kiss her, then say, 'I lost.'
Questions to Ask your Boyfriend
Floor him with these... he won't mind that they're silly. No way.
I am not feeling myself today, can I feel you?
Can I have a picture of you so I can show Santa what I want for Christmas?
Do you have a Band-Aid? I skinned my knee when I fell for you.
I am feeling a little off today. Would you like to turn me on?
Kiss me if I am wrong, but isn't today Sunday. (But of course it isn't.)
You don't need rocket science to get to the bottom of things, sometimes silly questions will do the trick just fine. So use them right and watch the fun you'll unroll.
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The BEST Episodes of Suburgatory
Every episode ever - ranked by fan votes!
Last Updated: Oct 23, 2019
Network: ABC (US)
Single father George only wants the best for his 16-year-old daughter, Tessa. So when he finds a box of condoms on her nightstand, he moves them out of their apartment in New York City to a house in the suburbs. But all Tessa sees is the horror of over-manicured lawns and plastic Franken-moms. Being in the 'burbs can be hell, but it also may just bring Tessa and George closer than they've ever been.
#1 - Apocalypse Meow
Season 2 - Episode 21
Dallas helps George tell Tessa that he has sold their house; when Dalia tries to make Tessa miserable, Tessa seeks revenge.
#2 - Stiiiiiiill Horny
Season 3 - Episode 13
When Tessa joins a knitting circle, the age of her new friends surprises George; George writes a song dedicated to his muse; Malik and Lisa bicker.
#3 - Krampus
Season 2 - Episode 7
George assumes that Tessa will be thrilled to go on an excursion with her mother in New York, but Tessa finds herself missing Chatswin and her father; the Shay family is thrown into turmoil when Ryan finds out he was adopted.
#4 - Stray Dogs
Season 2 - Episode 22
Sheila talks Mr. Wolfe into throwing a chastity ball at the high school; George buys Dallas her dream house.
#5 - The Barbecue
Season 1 - Episode 2
Surprised Tessa realizes she is attracted to her jock suburban neighbor; George feels pressured to throw the perfect barbecue.
#6 - Les Lucioles
Season 3 - Episode 12
Tessa struggles with the budget while planning Lisa and Malik's wedding; June warns Tessa to stay away from Ryan; Malik turns to George when his family decides to boycott the wedding; Sheila gives Lisa advice.
#7 - The Witch of East Chatswin
Season 2 - Episode 2
When Tessa convinces Dalia and her friends to think up feminist-inspired Halloween costumes, she attracts the attention of the Chatswin witch; Noah and George dress as each other; George misunderstands when Dallas asks him out.
#8 - Go, Gamblers!
Season 2 - Episode 20
Tessa helps Ryan choose a college; George asks Dallas to move in with him; Sheila sells George's house.
#9 - Charity Case
Season 1 - Episode 6
Irritated by all the cafeteria waste at school, Tessa motivates the student body to get involved with giving back. Unfortunately their charity of choice involves helping residents of Florida improve their complexions. When Tessa introduces a homeless transsexual to the student body as part of a lesson, they decide that Tessa is really the person in need. Meanwhile George receives a large dental bill from Noah, which puts a strain on their relationship.
#10 - Ryan's Song
Season 2 - Episode 3
Feeling guilty about keeping the truth from Ryan, Lisa agrees to help him with Tessa; Dallas invites her life coach along on her first date with George; Tessa baby-sits with Opus.
#11 - Homecoming
Season 2 - Episode 1
Tessa returns to Chatswin after spending summer with her grandmother; George finds Tessa's renewed interest in her mother threatening; Tessa signs up for the Fall Follies; Noah and Dallas compete for Carmen.
#12 - Catch and Release
Season 3 - Episode 8
Tessa asks for advice when Lisa decides to propose to Malik; George believes that Nora may be rude to her employees.
#13 - Chinese Chicken
Season 2 - Episode 10
George starts to feel stifled when Dallas' efforts to promote his business go overboard; Tessa learns what life is like as a football player's girlfriend.
#14 - Pilot
Season 1 - Episode 1
Tessa and her father experience culture shock when they move out of New York and into a house in the suburbs.
#15 - The Motherload
Season 1 - Episode 22
Tessa feels a void as Chatswin celebrates mothers; Dalia goes to Israel without Dallas; Eden reacts to a baby shower's theme.
#16 - The Nutcracker
Season 1 - Episode 9
When Tessa overhears George break up with his girlfriend, Zoe, on Skype, she blames herself for his failed relationship and decides that she's going to get them back together. Unbeknownst to her, though, George is really enamored with Tessa's cute art teacher, Aimee. He admits to Mr. Wolfe that he's over dating crazy city women, and that he's looking for love in the burbs. George decides to embrace the holiday spirit with a tree trimming party complete with ex-girlfriend, potential new girlfriend and the Royces, and he soon finds himself under the mistletoe with a special someone.
#17 - Halloween
Season 1 - Episode 5
Tessa channels her inner "suburban girl" for a Halloween costume, but it ends up spooking her friends and everyone at school since she reminds them of a recently "departed" resident of Chatswin. And George is determined to prove to Halloween-hater Dallas that being scared can be fun, but gets a scare of his own when Steven Royce (guest star Jay Mohr), Dallas' husband, finally comes home from one of his many business trips.
#18 - Thanksgiving
Season 1 - Episode 8
Depressed that she has to spend Thanksgiving in the suburbs, Tessa convinces Dallas to take her to the city for a girls' day out. During their fun day, they run across George making out with a woman while he was supposed to be "working." Angry with George for lying to her, Tessa confronts him during the Royces' Thanksgiving dinner. Meanwhile Lisa refuses to wear a special dress Sheila picked out for her, so Sheila decides to literally turn up the heat.
#19 - The Wishbone
Season 2 - Episode 5
Tessa decides to spend Thanksgiving in the city with her mom and grandmother; George hosts Thanksgiving dinner for Dallas.
#20 - Sweet Sixteen
Season 1 - Episode 7
When Tessa tells Dallas that she wants a simple get together for her sixteenth birthday, Dallas convinces her to let Dalia plan the ultimate birthday extravaganza at the country club, complete with a live performance by her favorite band, specialty drinks and go-go cages. Meanwhile George throws his back out and Sheila Shay takes it upon herself to care for him, even though George is terrified of her.
#21 - Foam Finger
Season 2 - Episode 4
When Dalia abandons her friends Kimantha, Kenzie and Kaitlyn to hang out with her father's fiancee, her former pals turn to Lisa and Tessa; George and Dallas take their relationship to the next level.
#22 - Out in the Burbs
Season 1 - Episode 11
When Tessa is asked to show new guy Josh Sherman around school, she becomes convinced that he's gay, when in fact he's an undercover narcotics officer. Lisa becomes deeply infatuated with Josh, and Tessa inadvertly convinces Mr. Wolfe to make special announcement to the student body. Meanwhile George re-evaluates his relationship with Dallas.
#23 - Entering Eden
Season 1 - Episode 19
George begins dating Eden (Alicia Silverstone), a woman he met at the town's farmer's market. Tessa helps Dalia find her missing dog.
#24 - I'm Just Not That Into Me
Season 3 - Episode 7
Tessa becomes enamored with the male version of herself she meets at a college party; a matchmaker inspires Dallas to transform her look.
#25 - The Great Compromise
Season 1 - Episode 21
While Tessa tries to adjust to living with Eden, George takes issue with Eden's parenting; Lisa and Malik consider which camp they should attend.


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Filtragem por: Palavra-chave Loss of confidence Remover Palavra-chave: Loss of confidence
Resultados da Busca
Creator: Duprey, James N. Series: Working paper (Federal Reserve Bank of Minneapolis. Research Department) Number: 071 Abstract:
This paper briefly recounts several of the key financial developments of 1974, describes the contingency planning exercise developed by the Minneapolis Federal Reserve Bank to encourage planning by large member banks, and then discusses some of the comments received in a trial run. The Appendix contains a copy of the exercise together with an illustrative example.
Palavra-chave: Banking, Contingency planning, Loss of confidence, 1974 banking crisis, and Emergency lending program Sujeito: G28 - Financial Institutions and Services: Government Policy and Regulation, G21 - Banks; Depository Institutions; Micro Finance Institutions; Mortgages, and E58 - Central Banks and Their Policies


text:
Sheila Marie Costa Cepeda
681 votes (24.57%)WinningCheck
For more in-depth information on this candidate, follow the links for each tab in this section. For most screenreaders, you can hit Return or Enter to enter a tab and read the content within.
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Are you this candidate? Add more info.


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Fabienne & Roy ~ Married!
Pasadena, California
Fabienne and Roy had a beautiful Gatsby inspired wedding in Pasadena. It was no surprise that every detailed was perfectly thought out since Fabienne is a wedding coordinator (aside from being super creative) and put a lot of time into everything! They celebrated with their family and friends at Noor in Pasadena at the Ella ballroom. Everything fit in so perfectly...from the photos at Pasadena City Hall to the sparklers at night. It was all about the glitz and glam and we loved it!
Time for the first look!
Fabienne & Roy's sweet baby boy :)
Ceremony time!
Wedding Venue ~ Reception & Ceremony: Noor Events in Pasadena
Coordinator: The bride herself! Fab Events
DJ: Steve Martinez www.djstevemartinez.com
Photography: Nataly Lemus Photography


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Post written by
Caroline Japic
Caroline Japic is Chief Marketing Officer at Pramata.
There's a great scene in the 2017 TV show Big Little Lies where a teenage girl, worried about her mother, asks her father, "You haven't noticed she's been a little agitated lately?" Her dad's reply: "Honey, agitation is her preferred state."
I sometimes think the same is true of marketers whenever we push forward into new methodologies, as we constantly do. It can be demanding, even stressful -- but we like it that way. For many of us, the latest source of preferred agitation is account-based marketing, an approach that treats each targeted account -- a customer or prospect -- as its own individualized market opportunity.
ABM has its roots in the IT sector and enterprise B2B vendors, but these days it's attracting attention across most industries and from companies of all sizes. That's where unnecessary angst can creep in. For those new to ABM, the whole thing can seem monumentally complex, requiring a huge stack of technology before you can even get started.
As I know from experience, that's simply not the case. ABM doesn't have to be hard and you don't need every popular tool. You just need to structure your initiative carefully before starting. Instead of investing in a huge stack of expensive marketing technology, start with a clear strategy.
At my company, we launched an ABM project that tripled prospect engagement within a quarter, and we did it without a massive investment in technology. Based on that experience, here are the five steps I'd recommend for those diving into the ABM deep end:
1. Focus on the right targets.
As with any other marketing project, knowing your audience is key. ABM is, by definition, a company-level approach; you're constructing detailed strategies and campaigns around individual organizations, treating each one as a market unto itself. You can probably reel off the names of your most important accounts, and those might be a great place to start. Buyers often feel underserved by their vendors on the information front. ABM can help you increase deal size and strengthen ties for future deals by keeping established buyers informed and up to date. That said, most practitioners will want to look beyond current customers to identify adjacent opportunities in their industry.
Once you've selected a key account, it's time to start thinking about the people in that organization. This starts in familiar territory for most marketers: persona research. What are the job titles? What do people do in those roles? How do they spend their days? It's not necessary to descend into demographics or to construct the imaginary profiles that many marketers like to use ("Peter is a CTO aged around 55 …"). A little creative imagination can't hurt, but the key is to know in detail the pressures, concerns and business challenges that confront these people and, as far as possible, the people in this particular company. Understanding your customer's pain is the best approach to defining the value your company can bring a certain persona.
With your targeted accounts and personas lined up, you're ready to research high-value contacts at the account. Tech tools are available to help with this, but doing the research manually works fine. It's time intensive, but it ensures that your contact data is correct and you are hitting your targets.
2. Build creative that targets your personas and accounts.
Again, marketers can leverage the familiar strategies of persona-based inbound marketing and content marketing. The goal is to attract interested buyers to your site with instructive, informative, thought-provoking materials that help them solve business problems or see them in a new light. You'll want to avoid an overly promotional tone -- but give a lot of thought to the calls to action in the materials and make sure they move the prospective buyer along to the next stage of the journey. We offered persona-based blogs, e-papers, whitepapers and webinars, as well as collateral targeting specific industries.
3. Digitally surround your accounts and personas.
Go where your high-value prospects are. Join and participate in the professional online forums where they hang out. What are their preferred communication channels? Where are they active in social media?
This is one area where the judicious application of third-party services or technologies can be worthwhile. Some ABM marketing software packages, for example, can serve account-based advertising to your targets across web, mobile, video and social channels. ABM allows companies to target and engage specific personas within their top accounts, which leads to higher conversion rates throughout the funnel.
4. When engagement happens, start emailing and calling high-value contacts.
One big advantage of ABM is that people who are already engaged are more willing to talk to you. Once the program swings into action, things can happen fast. It's essential that your sales teams are closely aligned from the start so they know what's coming. They'll need to be ready to mobilize all the traditional outbound marketing tools and practices, from emails to targeted offers to follow-up calls.
5. Optimize and improve.
Another advantage of ABM is that, because it's tightly focused on a market of one, it's relatively easy to adapt it as you go along. Watch your results closely. Tweak your creative and adjust your spend mix based on what you see, and look for opportunities to iterate.
At my company, we liked what we saw. Our click-through rate on emails increased by 600%. Digital ads are currently performing at 180% above industry standards. All while using a few key digital ABM tools that make a difference.
That's the kind of outcome that's well worth a bit of targeted agitation.


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Have you got an Amazon Echo or Google Home? Listen to Virgin Radio, Virgin Radio Anthems or Virgin Radio Chilled in no time.
There are skills available for all three stations,. Search for them on the Amazon Alexa app and enable on your phone, or ask Alexa to 'enable Virgin Radio UK', 'enable Virgin Radio UK Chilled' or 'enable Virgin Radio UK Anthems'.
To listen, say 'Alexa, play Virgin Radio UK/Chilled/Anthems'. Alexa will then tell you it is enabled and ask if you want to open it. Answer yes, and the station will play.
You can also access Virgin Radio UK, Virgin Radio Anthems and Virgin Radio Chilled via TuneIn and Radioplayer on Google Home or the Amazon Echo too. Just say 'OK Google, play Virgin Radio UK' or whichever station you would like. If it can't find it, say 'OK Google, play Virgin Radio UK/Chilled/Anthems on Radioplayer' or TuneIn.


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Popular Google Pages:
◕ Send your story to RiyaButu.com and get ₹ 500/- Details..
◕ Bengali Story writing competition. Details..
This article is regarding Remove Render Blocking of JavaScript / jQuery.
Last updated on: 28th November 2016.
◕ Render means loading or displaying. So if something is render-blocking, that means it is preventing the page from loading quickly. It is true that anything your webpage calls ( like .css or .js ), it will slowdown your page. More call more slow.
We all use jQuery in our Website or in Webpage. jQuery is a javascript file. If we check then we will find that normally it's file size is very large.
For an example:
Let my Webpage's file size is 5KB. But to make my webpage beautiful I am calling a jQuery file with a size of almost 70 to 100KB.
So why we should call such a big jQuery file when my page is just loading? We can call it later also, after loading my Webpage. There is no reason to load jQuery before loading my webpage. But most of us doing this.
◕ How can we call a jQuery file after loading my Webpage?
Very simple. Just put the following code between your head tags. It is better to put this code just before the closing head tag.
<script type="text/javascript">
function downloadJSAtOnload() {
var element = document.createElement("script");
element.src = "URL-OF-YOUR-jQuery-FILE.js";
if (window.addEventListener)
window.addEventListener("load", downloadJSAtOnload, false);
else if (window.attachEvent)
window.attachEvent("onload", downloadJSAtOnload);
else window.onload = downloadJSAtOnload;
Your mission is complete. You can check your Webpage speed on google speedchecker before and after using this code.
The path is
◕ All the best.
◕ Related articles:
► How to make XML Sitemap?
► Robots.txt Fetch Error
► How to find URL of my Twitter Account?
► Difference between .html & .htm
► List of wildcard used in MySQL
► MySQL match a string
► Eliminate render blocking CSS
► Eliminate Render Blolcking JavaScript or jQuery
► How google will trust a site?
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January 22, 2018
|Schedule for the week of January 22
|Monday - Even Block Schedule
Tuesday - Odd Block Schedule
Wednesday Minimum Day (12:30 dismissal) Open House/Home Show
Thursday - All Periods (typical Monday schedule)
Friday - Typical Friday Schedule
|SSHS Choir Fundraiser
|The SSHS Choir Department is selling Cords of Steel, 6 foot long charging cables wrapped in steel that work for both Lightning (Apple products) and micro USB (non-Apple products). The Cords are $20 and can be purchased from any Choir student. More information on the product can be found at http://www.cordsofsteel.com/
|Peer Tutoring
|Students at Santa Susana will be tutoring other students for free after school.
Tutoring will take place from 3:00-4:00 in the following locations:
Room 410 — Mondays and Tuesdays
Room 408 — Wednesdays
There is a math/science focus but all subjects are welcome including AP subjects.
Peer tutors wanted! Earn volunteering hours!
|STEAM Expo Informational Meeting
|Wednesday, January 24, 2018 12:30 PM to 1:00 PM
Please plan on attending this informational meeting if you are interested in participating in the STEAM Expo.
General information about the event
-project submission forms
-volunteer forms
Please contact Jasanpreet Pandher at email@example.com with any questions.
| Fifth Wall
Senior Project
|"Fifth Wall" will be performing in the PAC Friday, February 2nd at 7PM and Saturday, February 3rd at 7PM. This play is written and directed by Zak Cullen, a senior at SSHS for his senior project. The cast has been working on the play for a year now and are very excited to perform it. Fifth Wall is a love story set in the 80s. The play is free and no tickets need to be purchased. Seats will be on a first come, first serve basis. They will be taking donations during the play and all donations will go towards the Children's Hospital and the Bully Project. See you there!
|Swing is the Thing!
|The Santa Susana HS Performing Arts Boosters Present the first Annual Swing Night!
Featuring the talents of the Choral, Dance, Instrumental Music, Theater, and Tech Departments.
Friday, February 9, 2018. SSHS MUR 6:00 - 9:30PM
Come one, come all and dress up in whatever period swing attire you fancy!
6:00 PM Spaghetti Dinner in MUR *Music from the SSHS Jazz Combo
7:00 PM Clear tables for Dance Floor featuring the SSHS Jazz Big Band & Guests
8:00 PM Moorpark College Big Band
8:45 PM Combined SSHS and Moorpark College Jazz Bands Finale
9:00 PM Encore
$20 for Spaghetti Dinner & Dance
$10 for Dance (no food)
Tickets are available in Room 702 (Mr. Theisen/Instrumental Music) and at the door!
Concessions at event
|Instrumental Music Presents
Chamber Night
|Come see an evening of entertaining and educational Instrumental Music! Tuesday evening, January 23rd for SSHS Instrumental Music's first annual Chamber Night. Many small group performances will be taking place from 5:00-9:00 PM held in the Black Box, Activity Room, Library, and Choir Room. A list of who will be performing and where, will be located at the concession stand, (featuring hot chocolate, hot coffee, and desserts) right in the main quad outside the IM Room (702). Best of all, ATTENDANCE IS FREE, come and enjoy!
|Applied Science Series
| This year, SSHS will be hosting its first Applied Science Series to show case student achievements in the STEM field through research projects and presentations.
|College & Career Center
SAT Prep
Free College tours hosted by the Boys and Girls Club of Simi Valley
Pepperdine 2/16/18 12:00 PM - 5:00 PM
Tours include a full campus tour, presentation, and a Q&A session. Please see the attached flyers.
Contact Mrs. Wigdor in the CCC with any questions.
|Mock Trial Fundraiser
|Mock Trial is selling "World's Finest Chocolates " in Room 307. Come and get your chocolate (crisp, dark, milk, caramel, or almond) for $1/bar after school. The money goes to fund the Mock Trial competition held at the Ventura County Courthouse at the end of February. All chocolates are available while supplies last.
| Art Festival
Senior Project
| Santa Susana will be hosting their first Art Festival February 2, 2018, in the Santa Susana Library. It will be showcasing art, music, and poetry created by the students of Santa Susana High School. We are looking for any Santa Susana High School students that would like to enter their original artwork to be presented in the Art Festival.
|Work Permits
|Students need to have a minimum GPA of 2.0, maintain a 90% attendance rate, and have six or fewer periods of truancy. More information available on the CCC Work Permit page. Contact Mrs. Wigdor in the College & Career Center with any questions.
|Upcoming Events


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BringMeFood- Changing the way you eat...This involves collaboration with all eateries in an area and provides as an online food portal.
- Stage Full Product Ready
- Industry Food and Beverage
- Location Mangalore, KA, India
- Currency INR
- Founded August 2012
- Employees 4
- Website bringmefood.in
Company Summary
BringMeFood serves as an online food ordering portal that has tie-ups with big food brands/franchises like Dominos, KFC. We act as a hotline for food delivery service that serves to customers of all ages. Hence, we believe that our customer base is huge and all we need is capital to ensure regular service. BringMeFood has operated in NITK, Mangalore for 3 months and has generated a profit of Rs. 20000 by handling a business of Rs. 250000.


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Author Archives: EricJ
Kyocera Copier Apps in Denver- We Have Them All!
Do you own or have you leased a Kyocera Printer, Copier or MFP in Denver and want to learn more about apps that run on these devices? Automated Business Products is the Top Kyocera Dealer in Colorado and specializes … Continue reading
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The Paperless Office Challenge
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Search results
Alumni in the News
1997- Burkett Re-Elected Ohio Farm Bureau President Adam Campbell BS Agribusiness & Applied ... Economics 2009- New Young Ag Professional Committee Members Named Jessica Campbell BS Animal, Dairy & ... Poultry 2009- New Young Ag Professional Committee Members Named Dr.Graham Cochran PhD Agricultural ...
2020 Ag Outlook Meeting
The 2020 Ag Outlook Meeting is scheduled for Friday, January 24 at the Kidron Park ... lessen shocks and losses or provide protection in times of volatile markets and weathers. The 2020 Ag ... risks inherent in our agricultural world. Thanks to our sponsors, Farm Credit Mid-America, ...
Hardin County Master Gardeners Win State Awards
from the Ohio MGV Conference held November 8 at the Nationwide & Ohio Farm Bureau 4-H Center in ... Gardener display, and the educational garden. In doing so, they have allowed use of the facility in poor ... occurring when a program is scheduled. The facility is frequently used by local garden clubs and the ...
Farm Financial Management School
A 6-evening farm financial management school (FFMS) is scheduled for Wednesday evenings ... core farm financial documents and statements. The school will use presentations, class discussion, ... group work, case farm examples and hands-on activities to teach participants how to assemble and use ...
Environmental Film Series- Ice on Fire
climate change, Ice on Fire instead focuses on the cutting-edge research behind today's climate science ... carbon, including direct air capture, sea farms, urban farms, biochar, marine snow, bionic leaves and ... reforestation and creates "biochar" to put CO2 back into the soil; Ron Finley's urban farm in Los Angeles, where ...
In Over Your Head: Life-Saving Strategies for Financial Crisis
services as well as consolidation and other repayment strategies wisely; and how to determine if filing for ...
Ag Hall of Fame to Induct New Members
family had operated a 50-cow dairy farm in Allen County, near Harrod. Today they operate the small ... family farm as a grain operation. He has served on the Mid-Ohio Energy Cooperative board in Kenton for ... and operating DuLynn Farms with his wife Barbara. Together they raised registered Holstein cows and ...
Ag Council Breakfast
Breakfast Cost – No RSVP Roundtable Discussion of County Agriculture ...
Ag Council Breakfast
Breakfast Cost – No RSVP Roundtable Discussion of County Agriculture ...
Ag Council Breakfast
Breakfast Cost – No RSVP Roundtable Discussion of County Agriculture ...


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Elsternwick House provides a growing family with more space and greater amenity, while preserving and celebrating the heritage of their original home.
Clare Cousins Architects
Clare Cousins Architects is a Melbourne-based architecture and interior design practice founded in 2005 by Clare Cousins. The award-winning firm focuses on context, materiality and a collaborative client-architect relationship, with a portfolio including houses, residential extensions, retail projects and commercial projects.
Garden Room House / Clare Cousins Architects
Garden Room House's reconfigured smaller form feels more spacious than its larger predecessor. The garden room provides an opportunity for multiple green vistas throughout the home …
Contemporary Garden Pavilion Added to an Edwardian Cottage
This contemporary garden pavilion is a compact addition to an Edwardian cottage in Melbourne. Baffle house by Clare Cousins Architects integrates delightfully with both the existing bungalow and the garden area.
Flinders Lane Apartment by Clare Cousins Architects
How warm and cosy can an apartment be arranged that is almost entirely made of wood and plywood? I think the answer is provided sufficiently eloquent by the contiguous images. The project Flinders Lane Apartment realized by Clare Cousins Architects from Melbourne, Australia, implies the redevelopment of a 75m2 apartment for a young family. The […]
Beach House by Clare Cousins Architects
The Beach House from Mornington, Victoria, was designed by Clare Cousins Architects in order to provide an additional accommodation to an existing 1970's Merchant Builder's home where the owners can retreat and relax while enjoying the view of the ocean. Rather than demolish or renovate the Merchant Builder's home that is located on a sloping […]


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Paperback, Published in Oct 2008 by Buchanan Press
Page count: 272
Fun For One. This book contains all kinds of fun things to do by yourself. The 2 parts consist of things to do Indoors and things to do outdoors. Includes the rules and materials for a number of different games and crafts. Many of the earliest books, particularly those dating back to 1900s and before, are now extremely scarce and increasingly expensive. We are now republishing these classic works in affordable, high quality, modern editions, using the original text and artwork.


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The tour will run every day, rain, hail or shine. Please note:
To take part of our Free Tour reservation is mandatory.
Unfortunately it is not possible to participate without a reservation.
Reservation is totally free.
The tour is tips based only. ( You make the price !)
Our guides (all qualified by local authorities)
will do their best to deserve them.
Part of the collected tips will be donated for charity.
Currently our free tours are only in English,
we do not offer tours in Spanish or other languages.
Duration 2 hours approx.
In order to visit the Churches , Private areas and Some Monuments
which are part of NRFT free walking tour guest(s)
need to follow the appropriated Dress Code.
Check our Itinerary.
Click below to book our free tour.
Once Booked it is mandatory to print the ticket.
Our staff has to keep it.
More information at:


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To order images and/or obtain permission to use them commercially, please contact the KSHS Reference Desk at firstname.lastname@example.com or 785-272-8681, ext. 117.
For more information see the Copyright and Permission FAQ.
"Last Moments of John Brown" by Thomas Hovenden. A photograph of a painting that was painted nearly twenty years after Brown's death at the request of art collector Robbins Batrell. The scenes from the painting were based on a newspaper account of John Brown's trial which appeared in the "New York Tribune" on December 5, 1859.
Creator: Hovenden, Thomas
Date: 1884
Item Number: 208927
Call Number: B Brown, John * 42
KSHS Identifier: DaRT ID: 208927
Collections - Photograph
Date - 1880s - 1884
Government and Politics - Reform and Protest - Antislavery
Government and Politics - Reform and Protest - Antislavery - Abolition - Harpers Ferry, West Virginia
Objects and Artifacts - Communication Artifacts - Documentary Artifact - Photograph
People - Notable Kansans - Brown, John, 1800-1859
People - Notable People - Brown, John, 1800-1859
Thematic Time Period - Bleeding Kansas, 1854 - 1861
Type of Material - Photographs


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Hyatt Regency Dallas300 Reunion Boulevard
Dallas, TX 75207
(214) 651-1234
Distance In Miles:
- Kay Bailey Hutchison Convention Center:
- 0.9
- DFW International Airport:
- 20.3
- AT&T Stadium:
- 18.1
- American Airlines Center:
- 2.4
- Dallas Love Field Airport:
- 7.5
Located downtown next to the iconic Dallas landmark Reunion Tower, Hyatt Regency Dallas offers 1,120 modern guest rooms and 160,000 square feet of flexible meeting space just minutes away from the Dallas Convention Center, American Airlines Center and the Historic West End District and Dealey Plaza. Guests at the hotel enjoy complimentary wi-fi in every guest room, 24-hour access to the StayFit Gym and unique on-site dining options just feet from their hotel room. For more information about Hyatt Regency Dallas, visit hyattregencydallas.com or follow us @hyattdallas on Facebook, Twitter and Instagram.
Outdoor Pool
Pet Friendly
Room Service
Fitness Center
1120 Non-Smoking Rooms
Outdoor Pool
Pet Friendly
Room Service
Fitness Center
Car Rental Desk
Self Parking
Valet Parking
Wireless Internet


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Amy Edmondson, Ph.D.
Amy Edmondson is the Novartis Professor of Leadership and Management at the Harvard Business School, an endowe... Read Bio
This December, more than 1,200 individuals will convene in the nation's capital to ensure that evidence is used to inform decisions that will improve the health of individuals and communities.
The Fearless Health Care Organization: Creating Psychological Safety for Learning and Implementation
Raising the Bar on the Rigor, Relevance, and Rapidity of Dissemination and Implementation Science
As we continue to work collaboratively to enhance the research agenda supporting the dissemination and implementation of evidence and evidence-based interventions, we recognize the importance of reaching for ever greater improvements in the way in which science is conducted. We need our armamentarium of valid and reliable measures and research designs to grow in their quantity and quality. We need to ensure that the research questions we ask within our studies are as relevant to the multiple community, practice and policy stakeholders for whom our work is intended to benefit. And we need to improve the efficiency and pace at which our studies are conducted and our study findings are applied in healthcare and community practice.
This year's conference theme, Raising the Bar on the Rigor, Relevance, and Rapidity of Dissemination and Implementation Science, is intended to help us map the way forward for improvements in the development, execution and application of D&I science.
We are pleased to announce that several scholarships will be awarded to help cover travel expenses for select presenters from low and middle income countries (LMICs) to attend the conference.
Residents of a low or middle income country (as identified in the contact information of abstract submissions) who've had their abstract accepted (podium or poster), are qualified for a scholarship. Winners will be notified in early September (no application process), just after abstract notifications are sent out, and will receive travel reimbursement up to $1,000 USD as well as a complimentary registration to the conference. Note: awards given by NCI must focus on cancer.
Sponsored by AcademyHealth, the National Cancer Institute's (NCI) Center for Global Health, and Fogarty International Center's Center for Global Health Studies.


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United Kingdom, GBP 525 - 707 per week Loyalty bonus - Refer a friend scheme - Healthcare scheme, Employed (PAYE)
Become a Live-In Care Assistant for Bluebird Care Cornwall North and earn between £525 and £707 per week
We require a live-in care assistant in Bude, Cornwall.
This is a challenging but highly rewarding opportunity for the right person. Previous care experience is desirable and a willingness to learn is essential.
The role involves staying in the customer's home for a minimum of one week on, one week off, (which is negotiable) providing all aspects of care, including:
personal care, companionship, taking the customer shopping, medication support and domestic tasks.
We offer full induction and training.
All applicants MUST have a Full Driving Licence and a car.
Benefits & Rewards:
- Loyalty bonus
- Refer a friend scheme
- Vehicle Protection scheme
-work phone allowance
- 28 days paid holiday on a pro rata basis
- Healthcare scheme
- Comprehensive Training
- career progression plan and opportunities for you to undertake training which would lead to a Health and Social Care qualification.
Job Details


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A new report by the US-based National Academies of Science Engineering and Medicine suggests that not only has the automation of work barely begun but that the ways in which we measure the effects of technology on employment are inadequate to the task.
The authors argue that to understand how automation is transforming our workplaces, we need better ways of tracking technological change. Put simply, they are saying that if we are what we measure – that is, if policy is driven by the information we collect – then we are collecting the wrong information.
"Data on many of these trends are elusive, reflecting [the] changing nature of society and the economy, and gaps in [the] statistical infrastructure," the report says.
It points out, for instance, that we don't have a regular source of information about workers in part-time and other sorts of casual employment. Nor do we have good information about investment in computer technology at either the level of the company or of any given occupation.
Also lacking is long-term information about the way in which skills within particular jobs are changing, as well as data on how effective educational practices are in preparing people for work. Such information gaps undermine our ability to respond appropriately to technological change and its effects on employment.
This is a huge wake-up call for governments and businesses around the world who are proving slow to engage with the changing nature of work and who have tended to hide behind the mantra of "jobs and growth", as if that will take care of everything. It is a reminder to all of us that we are long way from understanding what the future of work really looks like.
The authors call for three new indices to be developed, tools that can be used to plug holes in conventional measures such as GDP, productivity and the unemployment rate – a technology progress index, an artificial intelligence progress index and an organisational change and technology diffusion index.
They set out the parameters of each in some detail and, in so doing, open up a much-needed discussion about the data used to help form public policy.
We tend to think of measures like GDP and productivity as eternal truths of economics and, indeed, they have proved their worth over time. Nonetheless, some of them are not only reasonably recent inventions, dating from around the second world war, but are designed to measure activity in an economy of mass manufacturing, a sector increasingly being displaced by the information economy as the primary source of global wealth. This means the measures themselves are also increasingly irrelevant.
As the economics professor Richard Holden wrote: "The IMF model suggests Australian unemployment falling to 5.2% … in 2017 and to 5.1% in 2018. But that is a pre-2008 model of how the labour market and macroeconomy interrelate. Maybe that's still the right model but I wouldn't bet on it."
As the entrepreneur and founder of Wired Magazine Kevin Kelly has said on the subject of productivity: "Productivity is for robots. Humans excel at wasting time, experimenting, playing, creating and exploring. None of these fare well under the scrutiny of productivity. That is why science and art are so hard to fund. But they are also the foundation of long-term growth."
To help understand the point Kelly is making, consider that a quarter of Britain's top actors have been kept in work over the last decade by Harry Potter films. So although JK Rowling may be a billion-dollar industry, her value as a contributor to national wealth does not improve by subjecting her to a stopwatch and increased output to improve her productivity.
What Kelly is saying is that, if you can measure a job's productivity, you can probably replace that job with a machine, so that when it comes to humans in the workplace we should be measuring different things. "[Our] notions of jobs, of work, of the economy don't include a lot of space for … experimenting, playing, creating and exploring," Kelly says, but those are the very skills that are likely to become more valuable in the workplaces of the future.
So the value that humans will increasingly bring to the workplace is to be not a robot, which will mean measuring our contribution by something other than inputs and outputs.
The National Academies report is not arguing for a wholesale replacement of traditional measures of economic activity but it is saying we need vast new supplementary data to better understand the ways in which new technologies are affecting the work that we do. Until we develop and implement these measures, it will mean that, on everything from education to welfare to employment policy, governments are flying blind.
The concerns of the report's authors are being driven by their belief that the technological disruption of employment has barely begun. They write: "Opportunities for digitising and automating tasks are far from exhausted. In particular, the workforce will be increasingly affected as more and more cognitive tasks become fully or partly automatable ... and as advances in robotics yield enhanced physical dexterity, mobility and sensory perception in machines. These trends will almost surely change the demand for the workers performing these tasks and the nature of the organisations in which they work."
And so the sooner we start accurately measuring what is happening, the better.