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About Antonio
Antonio is an internationally recognized leadership and workplace speaker, author (Penguin Random House) and award-winning broadcast journalist (NBC, PBS, BET, etc.).
"Antonio was our keynote speaker for our Sales Kick-off and he spoke creatively, emotionally, and personally to each of us. Antonio left us all feeling motivated and inspired to want to do better today than we did yesterday and to do better tomorrow than we did today."
Kevin Boland - Starwood Hotels & Resorts Worldwide
"Antonio's excitement helped refuel our managers at our statewide meeting. His humble demeanor and electric personality were a great fit with our culture and our managers couldn't stop talking about many of the takeaways Antonio left us with."
-Kent Oram, Idaho Central Credit Union President/CEO
"Antonio is an inspirational, charismatic and engaging motivational speaker who genuinely inspired our employees to think as positively and act as effectively as they can. Antonio's style is to lead by example whilst remaining humble. He was a pleasure to work as he has a can do attitude on all accounts. If your organization would like a to stop and think about how you connect and work together - and be the best you can be...you should hire him."
Scott Davenport - Global Learning Manager (Finance), Booking.com
"Antonio Neves is a natural storyteller. He has the ability to engage and connect with your audience and provides relevant advice and guidance to young professionals. He infused positive energy to an audience that was feeling pressure and concern about their future careers. We couldn't have asked for a more perfect speaker!"
-Diana Dabdub, Director - American Society of Health System-Pharmacists (ASHP)
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Even if financial institution had been to lower curiosity I must pay down at 1% per level. To get it at four% it will value me about 6k plus closing. I cannot refinace with one other financial institution as a result of I am 170k flipped on the home. I think I am the only one, however I never heard of it. We go to the video store each monday so I will see if they have it. Great lens.
I do know what you mean, Dolores. It IS a lot of work. About storing tropicals dry root, I think a number of folks wish to find out about this…maybe a Hub for you sooner or later? Thanks a lot for the vote and the great phrases. Commenters who signed up earlier than June 26th, 2014 should reregister on our new, social-friendly login system. The excellent news? The method should only take a few minutes, and you're welcome to make use of the identical electronic mail tackle.
Now, to your question about tax implications. If the residential property was owned just by you and your wife, and it was your principal residence, there could be no tax anyway when the property was bought or transferred on your demise. So you are not avoiding any tax by including your daughter's identify. Hello Peg – I should have needed a booster shot of inspiration this night. And I found it proper here. This is such an American story, it has such energy.
But most humbling for me, He writes about his hope for blessings on me, my household and my church household. I tell him that we've been so richly blessed by God in our lives and are honoured to have the ability to share with them. Glo, convey your tent and some sizzling dog skewers. We'll have a cook out. I've obtained marshmallows. Good luck in selling your house and preserve me posted. So glad to see you publishing more hubs.

subset: commoncrawl


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Tools and Views
I've spent part of two days helping some cousins get started in family history research this week. Both of them had some experience with family history software, so we focused on some other software tools to help in their quest.
Both of these sisters and I are now in a research 'team' working on our common ancestry. We are using e-mail and the telephone to coordinate our research efforts and have already enjoyed several research finds. Team up with your cousins whenever you can… you'll be surprised with your joint 'finds'.
Here is the free software they installed to assist in their research efforts. (The titles are links to the software web sites)
This free photo editing / organizing software is Powerful. It is amazing that it is free. If you decide to use it, the controls are found by pointing to the 4 sides of the screen.
The new team mates love this tool and are already using it to clean up, crop, etc. old family photos. (and they are sharing the results with me!)
Free …. A fast, easy to use Image Viewer. Add the plugin's from the site and you can also use it to listen to music, view video's. It is a great program that I've used for several years.
Free — View census images, hand written documents, etc. in the upper window while you type the transcription in the lower window. You can save the transcription as a text file or copy and paste the text to an event in your family history software. Try it. You'll like it. The link on this page is new. I talked to the author in the Netherlands yesterday and he has just moved his website to this new address.
Free — Firefox is my web browser of choice, but I use Opera more and more. It is extremely customizable. I've found that I use it most by having Opera 'read' web pages to me by using a simple voice plug-in from the Opera site. Now when I'm working on my records and have found a site with a history about my ancestor, area history, etc., I just highlight the text that I want to hear and let Opera read to me while I continue to work. (I even 'read' the histories on my own site when working on that individual… They bring many clues and 'To-Do's' to mind, thus enhancing my ancestor detective efforts..)era has built in e-mail if you want an 'all-in-one' program. If not, just don't turn it on in the settings. You don't hear as much about Opera, but it is a solid program that usually 'pushes' the other popular browsers to keep up…
Free — If you have a fairly fast Internet connection and aren't using Google Earth already get it! Google Earth lets you tour the world from your chair at home. I use it to plot the homes, headstones, migration, etc. of my ancestors. The new FamilySearch website has integrated Google Earth photos with family events plotted on them. I use Google Earth to scan the area for rural cemeteries, battle grounds, etc. associated with my family. You can often find them looking at aerial photos when an address description is almost useless.
Already have Google Earth installed? Great. Click on the attached file and press the 'Play' button in Google Earth to tour a few burial locations for some of my family. Now it is your turn to plot your own family homesteads, graves, etc. It is easy. Just read the help file… My attached file is simple, but you can easily make very detailed files if you want…
I have plotted all of the current temples and most of the announced temple locations in Google Earth files. Connie and I will never physically visit all of them with so many now in existence, but with Google Earth, we can 'visit' them from a satellite view..
When you are looking for towns, etc. surrounding a known ancestral location, consider using Google Earth. You'll be surprised how much a visual 'lay-of-the-land' can help you determine which little town or or larger city might have been the repository of family records, etc..
Lastly, a reminder to visit the Utah Digital Newspapers or a similar site for other locations. Thousands of new images have been added to this site recently. In less than an hour, I found the obituaries of my great grandparents and my wifes great grandparents, as well as many other references to family members.
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Ready to cook pappadoms from Natco. You are supposes to deep fry these as per the packet instructions, but I am not a fan of frying food, so I brush mine with oil and microwave for 30 seconds. This seems to cook them really well, they come out crispy and light. The poppadums made a great quick snack or go perfectly with any Indian meal. They keep for ages and make a good store cupboard food.
Each 200gram pack is suitable for vegetarians, vegan as far as I can tell. Sold in Supermarkets. Per 100grams uncooked is 371kcal.


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Laurus Flavour Master Bay Tree
Flavor Master Bay Tree is an excellent new columnar growing selection. Look out for the tasty recipes on the back of the label… Yum!
Key Features:
Laurus Flavour Master is a quicker growing Bay Tree with an upright coloumn forming habit. Flavour Master is great for using with many recipes.
Flavour Master Bay Tree rapidly grows to 1.8m making it perfect for column/standard production. It is practically a no trim topiary. To ensure your Flavour Master remains looking fantastic we recommend planting in a large tub or decorative pot, or in the ground. Be sure to use a high quality grade potting mix, positioned in a sunny or partly shaded position.
Plant Landscape:
Flavor Master Bay Tree is the ideal choice for the smaller garden, pot and container, not to forget use in the herb garden. This Laurus is very hardy. It is an excellent option for hedging those tight spaces in any landscape.
- Growth Rate: Moderate
- Max Height: 1.8m cm
- Size: 1.8m x 0.5m
- Position: Full sun to part shade, well drained.
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Xiapu & Zhangjiajie National Park
Join Thierry Bornier for a photographic workshop and discover a quaint and photogenic fishing village in Xiapu and the splendid Zhangjiajie Sandstone Peak Forest in Hunan Province.
May 11-21,2019
11-Days /11 nights Xiapu & Zhangjiajie National Park
Small Group – Small Group - min. 4 people, max. 6 people
Day 1 –May 11,2019: : Shanghai to Xiapu.
This morning, we will catch a fast train to Xiapu (5.5 hrs.), then transfer to the hotel for check-in.
Day 2 to Day 5– May 12-15 ,2019: : Xiapu
We will be spent amidst Xiapu's quaint fishing village atmosphere. Each morning will start early to catch the village's fisherman preparing their boats and nets for the day's work while the sun rises at their backs, their silhouettes against the shining waters from different angles.
After the morning shoots, the group will return to the hotel for a full breakfast and a rest. Then, spend the rest of each day exploring Xiapu's lively fish markets, quiet, rustic corners, creaking wooden docks, and much more. Every evening, the group will have dinner together, followed by a group discussion about technique and composition with everybody's photos.
Day 6 – May 16,2019 : Xiapu -Zhangjiajie
The day starts early with our last shooting, then we will take a high- speed train to return to shanghai and catch a flight in the evening after dinner to Shanghai city to spend the night in our hotel.
Day 8 –May 17,2019: : Zhangjiajie City to Zhangjiajie National Park
After breakfast, we will take a 1.5hr car ride from Zhangjiajie City to Tianzi Town, and check in at the local guesthouse, where we will be based for the next 4 days. We will have the first photography session in Zhangjiajie National Park the afternoon.
Day 9 to 12 – May 18 to 21,2019: : Zhangjiajie National Park
Each of these three days starts with a morning photography session to capture Zhangjiajie's magnificent landscapes. We will then return to the hotel for some rest. Later in the day, we will travel to a second location for more photography. In the evening, there will be dinner and group discussion to exchange ideas, tips, suggestions and analysis of the day's pictures. May 21 after our afternoon shooting, we will be transfer at night to catch our flight to shanghai and you will stay in Pudong international airport hotel.
Xiapu (Fujian Province)
Xiapu, known as the most charming fishing village in China, is located in the northeast of Fujian province. The village's surrounding hills provide great vantage points from which to compose stunning photographs. With your camera, recreate the scenes of traditional Chinese ink paintings, of the sun rising or setting, of fishing boats coming in and out, throwing and pulling nets behind them, and of massive nets strung between tall bamboo poles, hung with the day's prizes.
After the Yuanyang Rice Terraces, Xiapu is Thierry's second favorite location to shoot in China. The waters' easy currents and sunny weather make the village's mudflats rich in kelp, laver, oyster and yellow croakers. So, the village is not only a prime location to photograph fisherman at work, but also a great place to taste their fresh catches. Xiapu also has a bit of variety for photographers—low-lying beaches with stunning sunrise, working fishermen communities and a picturesque old banyan tree forest, just to mention some.
The Zhangjiajie National Forest Park
Zhangjiajie has become famous in recent years as the inspiration for the floating hallelujah mountains in the famous blockbuster movie – Avatar. One of the park's quartz-sandstone pillars, the 1,080-metre 'Southern Sky Column', has been officially renamed 'Avatar Hallelujah Mountain' in honor of the film. The magnificent scenery of the park certainly seems like it could be part of a celestial, magical world.
The pillar-like rock formations are the most notable geographic feature of the park. They are the result of many years of erosion, caused by expanding ice in winter and the plentiful foliage, due to the permanent moist weather. These formations are a distinct hallmark of Chinese landscapes and can be found in many ancient Chinese paintings.
Officially recognized as a UNESCO World Heritage Site in 1992, Zhangjiajie was also listed as a UNESCO Global Geopark in 2004. On this workshop, we will have great opportunities to capture these fascinating formations.
Haiyue Hotel Xiapu
This hotel is really a 5-star hotel. It's very new. The interior decors are new and trendy. The towels are white and soft. The services are good. While it is not located in the central main area of Xiapu, it has its own underground carpark and it is very convenient for those who are self-drive or who take taxis. Featuring free WIFI, HaiYue Hotel offers accommodations in Xiapu. Guests can enjoy the on-site bar.
Zhangjiajie national park Hotel
The Mountain Boutique Hotel is a great choice for guests looking for accommodation in Zhangjiajie, having been recently opened in 2017. Free in-room Wi-Fi is available at this property.
The hotel is located approximately 54km from Zhangjiajie Railway Station and 55km from Hehua Airport.
This hotel makes a great place to kick back and relax after a long day of sightseeing. For guests' convenience, airport pickup can be arranged.
There's never a dull moment at this hotel, our guests indicate that the facilities are excellent. This hotel is a popular accommodation for guests traveling with families.
Thierry Bornier
Thierry Bornier has been involved in professional photography since 2012 and is now a world-renowned photographer. Thierry is the winner of the Landscape Photographer Award, and is ranked fourth in the world's top ten black and white photographers in 2018.
In the past five years, Thierry's career has been well-received and enjoys a high reputation both at home and abroad, and his work has been published again and again in The Telegraph, Wired, and other well-known publications. Between 2015 and 2016, Thierry was nominated for the Best Landscape Photographer of the Year in China. National Geographic's "Daily Photo" also published its work in the Best Photographers' Works. In the past few years, Thierry has won various internationally renowned awards: The Epson International Pano Awards, One Eyeland, Sony Worldwide Awards, Lensculture, Px3 Paris.
recently he won the first place "the Top ten best Landscape Photographers in the World"
- Camera
- Tripod
- Zoom lens 70mm to 200mm minimum
- Wide angle lens 14mm to 35mm
- 85mm + lenses for portrait
- Filter polarizer ND filters: 0.6 ND and 0.9 ND, soft and hard (if possible)
- Workshop fees
- Private driver and vehicle
- Shanghai-Xiapu train tickets in First Class Seats
- Xiapu-Shanghai train tickets in First Class Seats
- Flight round trip Shanghai-zhangjiajie
- Hotels with daily breakfast
- Meals: full board
- Entrance fees park
- International airfares
- Visa fees
- Personal expenses
- Tips or gratuities for guides and drivers
- Medical services, travel insurance or visas
Cancellation and Refund Policy
We strongly recommend you get a Trip Cancellation & Travel Insurance after booking your trip. If you cancel and the Workshop is otherwise filled, we will refund you the full amount you have paid towards the tuition, minus a $300 service charge. If you cancel and the Workshop does not fill, then you will be refunded according to the following schedule, based on the full fee of the Workshop:
Greater than 90 days from the start date of the Workshop: full refund minus $300 service fee.
75 days or more: 75% refund
60 days or more: 50% refund
Less than 60 days: no refund
Refunds will be paid by the same method that the original payment was made.


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|Assistant Director of Athletics for Communications and Operations
|(718) 940-5834
|Previous College:
|Boston College '00
|Sport Administrator for:
|Women's Basketball, Softball
Anthony Macapugay joined SJC Brooklyn in 2008 and as the program's first-and-only full-time SID, however, his involvement with the Bears traces back to as early as 2001 where he was as a statistician and public address announcer for the men's and women's basketball teams.
He also serves as sport administrator for the women's basketball and softball teams, providing oversight and guidance for each program to help ensure their continued success in line with the Department's and College's goals and mission.
Macapugay is primarily responsible for all the media relations and communication efforts for the Bears' 14 intercollegiate varsity sports, overseeing the content creation for the department website, social media accounts, and print. Macapugay has helped place student-athletes in the New York Times, Daily News, Sports Illustrated, and Newsweek. In 2015 and 2016, he promoted the selection of SJC Brooklyn's first two College Sports Information Directors of America (CoSIDA) Academic All-Americans.
A former web developer and corporate intranet manager, Macapugay spearheaded four redesigns of the athletic department's website, SJCBears.com. He's grown the SJCBears social media presence to over 3000 combined followers for an institution with one of the smallest enrollments in the entire NCAA.
Arriving in Clinton Hill in the first year of the Division III provisional process, the Brooklyn native was heavily involved in assisting the department to achieve full membership on schedule in 2011. He later helped in the planning for The Hill Center—the college's first on-campus athletic facility—assisting with many of the design elements for the state-of-the-art 40,000 square foot facility which opened its doors in 2014.
Through his internship program instituted in 2009, he has helped start the careers of several former interns who currently hold head or assistant positions in sports information/athletic communications at all levels of the NCAA.
Outside of St. Joseph's, he is a game night statistician for the Brooklyn Nets and their G League affiliate Long Island Nets. Macapugay also serves as a statistician and public address for several local colleges and is a statistician for numerous basketball games and tournaments at the Barclays Center including the 2017 and 2018 Atlantic Coast Conference Men's Basketball Tournaments. He also serves as the director of sports information and championships for the Hudson Valley Intercollegiate Athletic Conference.
Macapugay received his Bachelors of Science in management, cum laude, from Boston College in 2000. He in is an active member of CoSIDA and served on their continuing education and new media committees.
A life-long Kings County native, he resides in Greenpoint, Brooklyn with his wife Jaclyn, an SJC alumna.


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Venue: Pan Pacific Orchard, Singapore.
Hong Cheong, my ex-colleague from the same department who has a pleasant personality. He smiles and laughs hysterically for most of the time. I know Hong Cheong and Yixin from Tzu Chi Foundation, an international humanitarian organization where we volunteering ourself to give back to the society. Since both of them are working in Singapore, they held a simple wedding banquet at Pan Pacific Orchard just to cater for their friends here. I am honoured to be their guest and actual wedding day photographer. It was a fun, simple and laughter-filled actual wedding day photography session as I know most of their guests. Best wishes to both of them!
Hong Cheong and parents
Yixin and parents
4 beauties from Tzu Chi.
Humorous speech by the couple
Kid also wanted to join the fun


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By Message Staff
LAFAYETTE – Organizers and participants of the 30th Youth Evangelism Celebration are thankful for the 1,081 students who made a decision for Christ.
"YEC was truly a celebration of the past and present," Louisiana Baptists Youth Ministry Strategist Steve Maltempti told the Baptist Message. "A history of excellence propels YEC forward. Students and teenagers are engaged with relevant entertainment and the Gospel message."
Held Nov. 19-20 inside Lafayette's Cajundome, YEC challenged Louisiana Baptist teens to share what Christ has done in their lives through messages by evangelist Clayton King. He encouraged students not to believe the lies of Satan but instead lean on God's truth.
"The biggest lie is God doesn't love you," King told the students during one of his messages. "That's a lie. God loves you. He loved you so much that He made a path for you to be saved."
During all four sessions, King offered a chance for students to step forward and declare a decision for Christ.
By the end of the two-day spiritual encounter, 1,081 students had made some type of faith decision: 325 statements of belief, 212 responses to a call to ministry, 463 acts of repentance to restore fellowship with Christ and 81 other commitments. Students will now be connected with a local church for follow-up and baptism will be encouraged.
The theme was "Now," based on 2 Corinthians 6:2.
In addition to messages by King, participants enjoyed music by Rush of Fools, acts of illusion by Brock Grill and testimonies from students around the state. YEC 2016 concluded with a time of music led by Building 429.
Students and adult leaders were also challenged to share their faith with classmates, family members, co-workers and others. During the Monday afternoon session, King led participants through a training session on how to use the Road to Life tract to share the Gospel.
This was the second of a seven-year rotation to equip students with tools to share Christ. For those who began as a seventh grader during the 2016 YEC, they will be trained with seven different evangelistic tools by the time they are a senior.
This is the final year for YEC in the Cajundome. Next year, YEC returns to the Rapides Parish Coliseum in Alexandria, where it enjoyed a 27-year run before renovations of the facilities forced a move to south Louisiana.
Look for a story later at baptistmessage.com and in a print edition of the Baptist Message.


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There is a lot of hype about the Internet of Things (IoT), as the technology has finally emerged into mainstream public view. IoT is changing our lives right from how we drive, to how we make purchases and even how we get energy for our home, and what not? But, there are also serious security risks associated with this technology. As the IoT ecosystem expands, so does the attack surface for cybercriminals to exploit and other potential threats and security issues and many companies are starting to look into vulnerability management software that may be able to help with their security. In this post, we will talk about the IoT vulnerabilities and a few potential solutions.
The Devil's Ivy: IoT Vulnerabilities
Co-authored by Felicia Williams (TechWarn.com)
Internet of Things (IoT) devices answer to our ever-growing desire for connectivity and convenience. A smart-appliances-integrated home gives us a glimpse of a utopic future with technology where our every need can be taken care of by robots and electronics. But dubbed as the 'Devil's Ivy', IoT devices are full of security flaws that can render your household vulnerable to serious cyber attacks. Before we look into that, it's important to know what the Internet of Things is.
What is the Internet of Things (IoT)?
The concept of IoT is broad but simple. The Internet of Things explains the web of connected smart devices that exist throughout the world. As smart devices have become more popular, the concept of IoT has grown in popularity. Lighting systems in homes can now be connected to the IoT as part of a smart home system. You can get a Home Lighting System installed by Crestron.
Just think back a few years, before self-driving cars and A.I home assistants like the Amazon Echo became popular. The only devices you had connecting to the Internet were your new smartphones and computers. Now, everything is made to connect to the internet. Cars, fridges, thermostats, the list is endless. With this evolution in technology comes downsides, the main downside is one of security.
With the concept of IoT just now booming in popularity, we are still in its early days. No new technology has ever had smooth early days, and IoT shows no signs of discontinuing this tradition.
Read: Scopes of IoT in the Banking and FinTech Sector
Security Issues and IoT Vulnerabilities
As smart devices continue to gain popularity, the security of these devices is being ignored. While the idea of the world being connected is a fascinating one, it may just create more problems than solutions.
With each smart device comes a new "backdoor" so to speak. For example, let's say you only had a smartphone and a computer. These two devices are the only devices of yours that can be hacked. If you have a home full of smart devices, the risk of being hacked increases. Though, this isn't that big of a concern. No one is focused on hacking a fridge or toaster.
But what about your smart cars? Medical equipment? TVs? These are smart products that we must be concerned with. Imagine your car is controlled by a hacker while you're on the highway. Scratch that, you don't need to imagine it; Multiple sites have tested the hackability of smart cars with terrifying results.
Security and hackability isn't the only issue. Many smart devices that connect to the internet don't use a form of encryption. Because of this, anyone with a decent understanding of technology could find ways to receive your data. You can encrypt a smartphone, but not your cars or assistants like Alexa. It's especially bad for home assistants, as they usually carry account data and request history. If anyone was to intercept this data, they could get into your account or worse.
Services like Denver IT Support can manage your business's IT needs remotely and even manage the security of your network so that you have piece of mind that someone with know-how is on top of things.
Technical Risks associated with IoT
In case a fire breaks out at your smart home while you are inside and if you don't have access to the manual overrides – you will get locked inside your house caught with fire.
If a bunch of sophisticated burglars hacks into your smart home security system, your home security and sensitive personal data will be compromised heavily.
Related Articles:
Cybersecurity in the Banking and Financial Services Sector – IoT Threats, Potential Solutions and Blockchain
IoT Enabled Smart Home Automation Using Renewable Energy Sources
Compatibility Issues with Commercially Available IoT Devices
The proprietary systems owned by big firms – Google, Apple, Amazo, and Facebook. Most IoTs are not compatible with other smart home systems and are built to be independent systems. For instance, Amazon's Alexa cannot control LG's intelligent refrigerators. Similarly, Apple and Google's IoTs are not built to be compatible.
This non-compatibility forces users to implement an IoT infrastructure from a single manufacturer, thus taking away important future-proof features like upgradability and flexibility. Users are further impeded when their technology becomes obsolete.
Apart from the above technical risks, there are many social and commercial risks involved with IoT. Read the full article IoT for Smart Homes is potentially dangerous.
Not all hope is lost though. Cybersecurity is making gradual advancements in the IoT, and while we must wait, there are a few things we can do to protect ourselves.
Solutions to a Widespread Problem
There are two groups that hold power to aid in cybersecurity: the developers of the product, and the consumers of the product.
Some may scoff at the prospect of the consumer having to solve the security issue on their own, but it's what needs to be done until companies set standards for security in smart devices.
On the developer's end, it's important to set standards across the industry. Cybersecurity is the standard that must be focused on. Internet of Things is still a new concept to some companies, and the concept will only continue to grow. As growth continues, standards must be met.
Cybersecurity to Counter IoT Vulnerabilities
The cybersecurity standard must keep the user in mind. The user's data should be protected always through encryption. Smart devices need security checks and fail-safes. There are many ways to set high standards in the industry, but many companies must adopt before others follow suit. Developers have the job of making sure these standards are kept and continued through the years.
Users, on the other hand, don't have as much on their plate. Us users count on the developers to keep to standards. Because of this, any attempts made by us may feel hopeless. But this isn't the case.
VPN routers are important for security. In case you may not know, a VPN, a Virtual Private Network, is used to keep your data encrypted as it travels to and from the Internet. This keeps the data secure and makes the data seem invisible to outsiders looking for the data.
While software VPNs exist, a VPN router is the most secure option for home and business users. Instead of encrypting data at the software level, data is encrypted at the hardware level. This way, your smart devices have no choice but to keep data encrypted, as all data must go through the router.
Avoiding IoT Security Pitfalls
According to IBM, IT professionals and device owners must take security into their own hands by following basic IoT best practices. The most important rule of thumb for IoT devices manufacturers is to test security during each phase of the development process. It is much easier (and less costly) to nip security issues in the bud during the prerelease stages than to waste resources fixing bugs after devices have infiltrated the market.
Protecting Data Privacy
For organizations deploying IoT technology, it's crucial to establish an incident response team to remediate vulnerabilities and disclose data breaches to the public. All devices should be capable of receiving remote updates to minimize the potential for threat actors to exploit outlying weaknesses to steal data. In addition, security leaders must invest in reliable data protection and storage solutions to protect users' privacy and sensitive enterprise assets.
To ensure the ongoing integrity of IoT deployments, security teams should conduct regular gap analyses to monitor the data generated by connected devices. This analysis should include both flow- and packet-based anomaly detection.
Awareness is the Key to IoT Security
As with any technology, an organization's IoT deployment is only as secure as the human beings who operate it. Awareness training and ongoing education throughout all levels of the enterprise, therefore, are critical. This applies to both device manufacturers and the companies that invest in their technology
Tread Carefully with IoT
As we said before, the Internet of Things has grown, is growing, and will continue to grow. With the growth of this concept and the smart devices that accompany it, cybersecurity will need to keep up. Until then, cybersecurity will remain a challenge and the holes must be patched by developers and users alike, and users considering getting more IoT devices should tread carefully and invest in the right tools for proper protection.
The IoT has the potential to boost efficiency and productivity in both domestic and enterprise settings. However, the exposure of IoT data — or the illegal takeover of devices themselves — can cause immeasurable damage to a business' bottom line and reputation. The keys to unlocking the benefits and avoiding the pitfalls of this technology include embedding security into apps and devices throughout the development life cycle, investing in robust data protection solutions and prioritizing security education throughout the organization.
If everything in the world was ideal, an IoT takeover would be nothing but smooth. Security would keep up with smart devices at every turn. Smart devices would be able to encrypt data on the fly without user intervention. The average citizen would never need to worry about their data being stolen or viewed. All of this is ideal but impossible. Until the standards of cybersecurity are updated to follow the trend of IoT, we must keep a close eye on our data.


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Mumbai - Trivandrum
Jun 12, 2005
|We embarked on a 34 hr journey by train to the deep south. Since this was our first train trip in India and since it was pretty hot out, we opted to pay a little more for such a long train ride. We went A/C 2 tier, which meant that we had 3 bunk beds in our berth, with a curtain separating 2 of the bunk beds from the 3rd, which was out in the hallway. We shared ours with a lovely family from Mumbai, who were on a pilgrimage down to Guruvayur.
The ride down was very comfortable, and unlike the train conductors in China who liked to screech to a halt a each station, the journey was very smooth. We slept through the entire night. There was a pantry car onboard and chai (tea) and coffee wallahs would walk up and down through the cars calling out 'chai! chai?' 'coffeeeee? coffee coffee coffeee!'. At each stop along the way, vendors would get onboard and sell snacks also. It took us a while to figure out what they were saying, so we missed a few things that looked good. We had samosas, vegetable cutlets, and other vada (fried snacks). The meals onboard were great, too. We had our first masala dosas in India for breakfast.
The scenery was also pretty amazing. It was sunny when we left Mumbai, so we had pretty good visibility up until almost Goa, when it got dark. The landscape changed and gradually became greener and greener as we got further south. By the time we reached Kerala, we saw palm trees, rice paddies, and rain. Lots of rain.
It was late in the evening when we arrived in Trivandrum, so it was off to find a hotel and a good dinner.


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Already across much of the world the New Year is upon us, and here in California we have only a few hours of the old year left. As they say, 2013 is definitely in the rear view mirror at this hour.
I am starting the New Year off on a good foot: by the end of this evening I will have canvas cut for a new project and I intend to spend much of the day tomorrow starting it. I have thread, scissors, lots of new gadgets and many hours waiting for me to pick up my needle.
I also have a new toy and I am on my way to Apple in the afternoon for a lesson on using my new toy. Yes, I've at last given up my old people's phone in favor of an iPhone which I already don't know how I lived without.
Nice that I have a chance to work on both of my favorite activities on New Year's Day and hopefully it will be a harbinger of good things to come in 2014.
So Happy New Year! May your days be filled with beautiful threads, wonderful colors, perfect tension and projects you love.
Gay Ann
Tuesday, December 31, 2013
May Your New Year be filled with many hours of stitches
Posted by Gay Ann Rogers at 5:32 PM
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Ryan Kent hailing from Vancouver, Washington makes these unique custom dabbers shaped like an AK 47.
So hot and awesome! Each one is fashioned like an AK 47 with a tommy gun magazine style clip. The gun dabber comes to a point and even has a realistic handle and stock.
Hard core dabbers only!
Average rating:
Not as pictured, 13th Feb 2017
Reviewer: Halleigh K.
Although this is pretty and well made it's not really what I wanted. The carb cap on the one I received is on the bottom of the dabber not where it is pictured I know these are handblown and subject to changes but that's kind of a big difference if you ask me...just looks less like an AK and more like a dabber. Still beautiful and quality work just keep that in mind if you're ordering and be VERY specific about the color you want I thought I was clear but not enough or they just didn't have the color in stock. That being said it got here just in time for Valentines Day: ) and the label is perfect you'd never know you ordered from a head shop!! Thank you guys
Cool as hell!, 25th Jun 2016
Reviewer: Aaron P
All my gun nut friends love mine. The magazine part can be used as a carb cap for easy transfer between taking the dab and caping it. That reason alone makes it one of my favorite tools to glob with.


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By Corona at September 05 2019 09:02:33
Look at the assumptions you baked into your original plan. Did the city follow through on opening that new park across from your location? Were insurance rates what you expected? How many hours of accounting or web design help did you really need? Are your online inquiries out_stripping your face_to_face sales? Or vice versa?
So when using one or more of these 7 ways to increase profit, the first one (adding more customers) might be the one you want to focus on last. It's probably more expensive. Now, if you had your plan completed and it showed what your business needed to do over the next 10 years to give you the salary and profit you wanted, the next thought would be how do I make it happen. Well the best way would be to take it one year at a time. Concentrate on next year first and then choose one or more of 2 through 7 to work on before trying to add customers.


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The first part of registering a new trademark is to conduct a search to make particular the chosen mark is free to help you. A search can normally be completed inside of a week. However, in urgent cases a search can be done within 24 hours, although there become extra costs to do this.
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Hard Credit Checks vs. Soft Credit Checks: What You Should Know
May 21, 2018
If you have been shopping around for a loan, you may have heard the terms soft credit check and hard credit check come up often. Anytime a bank or lender checks your credit, an entry will be reported on your credit report.
This is due to the fact that multiple credit checks over a short period of time (less than 1 month) can raise a red flag to lenders and anybody else that could be interested in your credit score.
Institutions that check your credit can either perform a hard credit check or a soft credit check. So what's the difference between a soft credit check and a hard credit check?
What is a Soft Credit Check?
Soft credit checks, also known as a soft inquiry, are inquiries that are made on your credit but do no impact your score at all. They are harmless to your credit report. A soft credit check occurs when you are checking your own credit, renting an apartment, and more.
Employers who check an applicants credit score will also typically perform a soft credit check.
What is a Hard Credit Check?
A hard credit check is performed when a creditor is qualifying an applicant for a hard money loan. A hard credit check occurs when you are looking to get money from a lender, whether for a loan, credit limit increase, or a new line of credit.
A hard credit check is also known as a hard credit inquiry or a hard credit pull. A hard credit check can have a small impact on your report and your credit score.
You can expect to receive a hard credit check if you are applying for an auto loan, mortgage, or personal loan. Your score may drop by 5-15 points with a hard credit inquiry.
It's best to avoid applying for multiple lines of credit in a short period of time, as it can make lenders think you are in a money bind.
However, the 3 major credit reporting agencies also recognize that consumers will shop around for the best rates. If you apply for all of your loans within a 14-day period, all of the hard inquiries will just count as one single hard inquiry.
Difference Between Hard and Soft Credit Checks
A soft credit check will show the same exact information as a hard credit check. This information can include any outstanding loans, lines of credit, and your payment history.
A hard credit check, on the other hand, is mostly used when applying for a new line of credit or a higher spending limit. A hard credit check lowers your score because it signals to other creditors that you are trying to borrow money, and creditors must see that you can handle repaying the loan.
When a lender checks your credit score, a log will remain in your report that shows who the lender inquiring about your score was and for what reason.
All credit checks ( hard and soft credit inquiries) are logged by the 3 major credit bureaus for at least 2 years. Having a hard credit check performed can actually slightly lower your credit for around 1 year.
The 3 bureaus collect data and information related to your borrowing to produce a 3 digit score that tells the lender how "creditworthy" you are.
When your credit score is high, so is your chance of getting approved for a lower interest loan.
Whether its a car loan, mortgage, or personal loan, a lender will go through your credit report or score to determine if you are able to repay them.
Potential employers are also known for checking credit reports and scores when hiring. All of these examples are soft credit check situations.
Final Note
For most people with an established credit history and solid repayment records, a hard check should not affect your credit score too heavily. If you are a younger borrower with a shorter credit history, a hard check may have a larger impact on you.
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Leura Cascades is just a short drive from the centre of Katoomba in the Blue Mountains, around 60Km West of Sydney.
This is a reasonably easy walk (with the exception of some ladders) with spectacular views, waterfalls and lush temperate rainforest.
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The Team @ Platypus Paparazzi Photography


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Alexander Hamilton's 11-point Plan for "American Manufactures"
A full view having now been taken of the inducements to the promotion of manufactures in the United States, accompanied with an examination of the principal objections which are commonly urged in opposition, it is proper, in the next place, to consider the means by which it may be effected.…
In order to a better judgment of the means proper to be resorted to by the United States, it will be of use to advert to those which have been employed with success in other countries. The principal of these are—
I. Protecting duties—or duties on those foreign articles which are the rivals of the domestic ones intended to be encouraged.
Duties of this nature evidently amount to a virtual bounty on the domestic fabrics, since by enhancing the charges on foreign articles, they enable the national manufacturers to undersell all their foreign competitors.…[I]t has the additional recommendation of being a resource of revenue. Indeed, all the duties imposed on imported articles, though with an exclusive view to revenue, have the effect in contemplation; and, except where they fill on raw materials, wear a beneficent aspect towards the manufacturers of the country.
II. Prohibitions of rival articles, or duties equivalent to prohibitions.
This is another and an efficacious mean of encouraging national manufactures;…Of duties equivalent to prohibitions, there are examples in the laws of the United States…but they are not numerous.…[I]t might almost be said, by the principles of distributive justice; certainly by the duty of endeavoring to secure to their own citizens a reciprocity of advantages.
III. Prohibitions of the exportation of the materials of manufactures.
The desire of securing a cheap and plentiful supply for the national workmen, and, where the article is either peculiar to the country, or of peculiar quality there, the jealousy of enabling foreign workmen to rival those of the nation with its own materials, are the leading motives to this species of regulation.…It is seen at once, that its immediate operation is to abridge the demand and keep down the price of the produce of some other branch of industry, generally speaking, of agriculture, to the prejudice of those who carry it on; and though if it be really essential to the prosperity of any very important national manufacture, it may happen that those who are injured in the first instance, may be eventually indemnified, by the superior steadiness of an extensive domestic market depending on that prosperity: yet in a matter, in which there is so much room for nice and difficult combinations, in which such opposite considerations combat each other, prudence seems to dictate, that the expedient in question ought to be indulged with a sparing hand.
IV. Pecuniary bounties.
This has been found one of the most efficacious means of encouraging manufactures, and it is in some views the best; though it has not yet been practised upon by the government of the United States, (unless the allowance on the exportion of dried and pickled fish and salted meat, could be considered as a bounty,) and though it is less favoured by public opinion than some other modes, its advantages are these—
1. It is a species of encouragement more positive and direct than any other, and for that very reason, has a more immediate tendency to stimulate and uphold new enterprises, increasing the chances of profit, and diminishing the risks of loss, in the first attempts.
2. It avoids the inconvenience of a temporary augmentation of price, which is incident to some other modes, or it produces it to a less degree; either by making no addition to the charges on the rival foreign article, as in the case of protecting duties, or by making a smaller addition. The first happens when the fund for the bounty is derived from a different object (which may or may not increase the price of some other article, according to the nature of that object); the second when the fund is derived from the same or a similar object of foreign manufacture. One per cent. duty on the foreign article converted into a bounty on the domestic, will have an equal effect with a duty of two per cent. exclusive of such bounty; and the price of the foreign commodity is liable to be raised, in the one case, in the proportion of one per cent; in the other, in that of two per cent. Indeed, the bounty, when drawn from another source, is calculated to promote a reduction of price; because, without laying any new charge on the foreign article, it serves to introduce a competition with it, and to increase the total quantity of the article in the market.
3. Bounties have not, like high protecting duties, a tendency to produce scarcity.…
4. Bounties are sometimes not only the best, but the only proper expedient, for uniting the encouragement of a new object.…
The true way to conciliate these two interests, is to lay a duty on foreign manufactures, of the material, the growth of which is desired to be encouraged, and to apply the produce of that duty by way of bounty, either upon the production of the material itself, or upon its manufacture at home, or upon both.…
[P]ecuniary bounties are in most cases indispensable to the introduction of a new branch.…Bounties are especially essential, in regard to articles, upon which those foreigners who have been accustomed to supply a country, are in the practice of granting them.
The continuance of bounties on manufactures long established, must almost always be of questionable policy; because a presumption would arise in every such case, that there were natural and inherent impediments to success But in new undertakings, they are as justifiable, as they are oftentimes necessary.…
V. Premiums.
These are of a nature allied to bounties, though distinguishable from them in some important features.
Bounties are applicable to the whole quantity of an article produced or manufactured, or exported, and involve a correspondent expense—Premiums serve to reward some particular excellence or superiority, some extraordinary exertion or skill, and are dispensed only in a small number of cases. But their effect is to stimulate general effort.…
VI. The exemption of the [raw] materials of manufactures from duty.
The policy of that exemption, as a general rule, particularly in reference to new establishments, is obvious.…Of a nature, bearing some affinity to that policy, is the regulation which exempts from duty the tools and implements, as well as the books, clothes, and household furniture of foreign artists, who come to reside in the United States; an advantage already secured to them by the laws of the Union, and which it is, in every view, proper to continue.
VII. Drawbacks of the duties which are imposed on the materials of manufactures.…
[S]uch drawbacks are familiar in countries which systematically pursue the business of manufactures; which furnishes an argument for the observance of a similar policy in the United States; and the idea has been adopted by the laws of the Union, in the instances of salt and molasses. It is believed that it will be found advantageous to extend it to some other articles.
VIII. The encouragement of new intentions and discoveries, at home, and of the introduction into the United States of such as may have been made in other countries; particularly, those which relate to machinery.
This is among the most useful and unexceptionable of the aids which can be given to manufactures. The usual means of that encouragement are pecuniary rewards, and, for a time, exclusive privileges. The first must be employed, according to the occasion, and the utility of the invention, or discovery. For the last, so far as respects "authors and inventors," provision has been made by law.…
It is customary with manufacturing nations to prohibit, under severe penalties, the exportation of implements and machines, which they have either invented or improved.…As far as prohibitions tend to prevent foreign competitors from deriving the benefit of the improvements made at home, they tend to increase the advantages of those by whom they may have been introduced; and operate as an encouragement to exertion.
IX. Judicious regulations for the inspection of manufactured commodities.
This is not among the least important of the means by which the prosperity of manufactures may be promoted. It is, indeed, in many cases one of the most essential. Contributing to prevent frauds upon consumers at home, and exporters to foreign countries—to improve the quality and preserve the character of the national manufactures…
X. The facilitating of pecuniary remittances from place to place—
Is a point of considerable moment to trade in general, and to manufactures in particular; by rendering more easy the purchase of raw materials and provisions, and the payment for manufactured supplies. A general circulation of bank paper, which is to be expected from the institution lately established, will be a most valuable mean to this end.
XI. The facilitating of the transportation of commodities.
Improvements favouring this object intimately concern all the domestic interests of a community; but they may without impropriety be mentioned as having an important relation to manufactures. There is perhaps scarcely any thing, which has been better calculated to assist the manufacturers of Great Britain, than the meliorations of the public roads of that kingdom, and the great progress which has been of late made in opening canals. Of the former, the United States stand much in need…
These examples, it is to be hoped, will stimulate the exertions of the government and citizens of every state. There can certainly be no object, more worthy of the cares of the local administrations; and it were to be wished, that there was no doubt of the power of the national government to lend its direct aid, on a comprehensive plan. This is one of those improvements, which could be prosecuted with more efficacy by the whole, than by any part or parts of the Union.…
The following remarks are sufficiently judicious and pertinent to deserve a literal quotation: "Good roads, canals, and navigable rivers, by diminishing the expense of carriage, put the remote parts of a country more nearly upon a level with those in the neighborhood of a town. They are upon that account, the greatest of all improvements."…
It may confidently be affirmed, that there is scarcely any thing, which has been devised, better calculated to excite a general spirit of improvement, than the institutions of this nature. The are truly invaluable.
In countries where there is great private wealth, much may be effected by the voluntary contributions of patriotic individuals; but in a community situated like that of the United States, the public purse must supply the deficiency of private resource. In what can it be so useful as in prompting and improving the efforts of industry?
All which is humbly submitted.
Secretary of the Treasury
Note: This excerpt has been edited for length by the author, eliminating Hamilton's debate with Jeff erson over an industry- versus agriculture based economy. The italics are Hamilton's.
Source: http://www.archive.org/details/alexanderhamilt00caregoog


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The AMG-2000 Series Entry Station is designed for multiple uses, typically at the unattended entrances of a parking facility. The entry station dispenses magstripe tickets, accepts access and credit cards for ticket in/card out and card in/card out functionality.
The integrated FlexScan™ QR400 extends the functionality of the standard entry station adding the capability to scan linear and QR barcodes. Credentials can be scanned from various printed and electronic media formats including paper, event tickets, ID badges and smartphones.
Utilize the iConnect® Interface tool for custom integration with your IT operation. Control the process all the way to the lane.
- Standalone (AMG-2070 series) or on-line (AMG-2570 series)
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Show Mom how much you appreciate her…and her cooking…with one of these Mother's Day gifts. Every time she uses the measuring spoons or takes a sip of wine, she will think of you!
Mom can journal about her new favorite recipes or tuck an old one into the specially added pockets of this recipe journal from Anthropologie.
This wine glass from Fred will allow Mom to savor the "leftover" vino while cooking…or measure out an extra 1/2 cup for herself!
This tasselled oven mit from ModCloth is cheerful for spring. It's so cute it may even inspire Mom to make a batch of baked goods for you!
Mom will be getting lots of compliments about these hip, ombre wooden spoons from Etsy. (Just don't fib that you crafted them yourself!)
This "Hold Me Mug" from Uncommon Goods is shaped for the contours of hands. Perfect for Mom to relax with a cup of tea.
We know Mom always adds lots of love into her cooking, but with these measuring spoons from Francesca's Collections she can also add a dash of faith, hope and joy!
What are your family traditions for celebrating Mother's Day? If you're treating mom to breakfast in bed, I think she may like these Crème Brûlée French Toasts from Smitten Kitchen!
Love food. Love self. Love life.


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Non-toxic and chemical free Chemfree Toilet Clean toilet bowl cleaner is one of the greenest and most eco-friendly ways to help keep your toilet clean for 5 years or 50,000 flushes minimizing the need for chemicals. (Safe for Septic systems!).
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Hydro-electric power plants use the physics principles incorporated in the non-toxic ChemFree Toilet Clean toilet bowl cleaner to keep water intakes clean for years. Made in the U.S.A., eco-friendly and non-toxic, Chemfree Toilet Clean's hydro-mineral magnets prevent toiletbowl stains by keeping minerals in the water from forming bonds that cause the stains in the bowl and the lime buildup that occurs on the tank parts.
Just drop it in the tank.
As an added bonus, the ChemFree Toilet Clean housing contains Bact-O-Bane, a non-toxic fiber embedded into the housing that kills bacteria on contact by disrupting the metabolic function of thin-walled micro-organisms like mold and fungus. This is backed up with a 5-year 50,000 flush study that shows no deterioration in performance. Get one for each toilet today. Safe for septic systems.
IMPORTANT: Chemfree toilet cleaners are designed to minimize the need for chemical cleaners. Chemfree will not clean a dirty toilet, you do need to start with a clean toilet. And it may require two for extra hard water. Your toilet will still require the occaisional brushing, but you will substantially reduce the amount of cleaning chemicals required to keep your toilet clean. In some cases, if your toilet water comes from a water softner it may not work as well. ChemFree MSDS.


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As a person with mesothelioma, you're in a difficult situation. You may survive for a long time with this disease, but there are no guarantees. The disease, as it progresses, is painful and suffocating.
What are the treatment options for people with mesothelioma?
Exposure to asbestos: The development of disease
As someone who worked with asbestos in the past, you may worry that you could develop an illness in the future as a result. In the meantime, you don't know when the illness might suddenly appear but want to take steps to address it as soon as possible.
Mesothelioma diagnosis? Be proactive in your own care
If you're one of hundreds of people in Pittsburgh and surrounding Pennsylvania regions who have recently learned they have mesothelioma, you likely have experienced a wide range of emotions regarding not only your present condition but your future, your family and more. You may have suspected that something was wrong for quite a while before your doctors diagnosed your condition; perhaps, you had a lingering cough or chest discomfort that was dragging you down.
Get the facts about mesothelioma
Mesothelioma may not be exactly what you think it is. As someone who has been recently diagnosed, you might think it's just another kind of cancer. However, it's typically caused by inhaling asbestos, which could mean that a past employer can be held liable for your current condition. The condition can take many years to form in the body, so you may never be ill when you're on the job.
Pennsylvania has second-highest mesothelioma rate in the nation
Whether you were born and raised in Pittsburgh or another Pennsylvania town, you or someone you know may have been adversely affected by microscopic fibers in asbestos products. There is no such thing as safe asbestos exposure. While evidence exists to suggest that symptoms of asbestos-related diseases may take a long time to surface, there is no way of knowing how much exposure or how often it takes to contract an asbestos injury.
Understanding the dangers of asbestos
Asbestos, a heat-resistant, fibrous silicate mineral has many purposes. It can be used as a fire-resistant or insulating material. It can be woven into materials, too. The trouble is that it has the potential to be extremely dangerous if inhaled.
Did employer negligence cause your terminal illness?
Like many Pennsylvania residents, especially those who once worked in the steel mills or coal factories in Pittsburgh, you may have been shocked and saddened when you learned that your employer knew you were at great risk for terminal illness but failed to fulfill the obligation to keep you safe. If you're suffering from asbestosis, mesothelioma or another asbestos-related illness, it may have been years before you found out the source of your symptoms.
What is mesothelioma, and who is at risk of developing it?
You worked in the steel industry for many years, which is why it's not necessarily surprising that you've developed mesothelioma. It took time to get a proper diagnosis, but now that you have it, you want to know what you can do to protect yourself and loved ones along with getting compensation for the asbestos exposure that led to your illness.


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Data from the BRIM3 study shows that patients with the mutated BRAF gene who were given the twice daily vemurafenib pills were significantly more likely to be alive at 6 months than those receiving dacarbazine.
The Institute of Cancer Research (ICR) was responsible for key research on the BRAF gene, which paved the way for the development of this first-of-its-kind personalised treatment for advanced melanoma.
Based on the significance of the data, the trial was halted early as it was deemed unethical for patients to continue receiving standard chemotherapy and not vemurafenib.
Vemurafenib, a new generation tailored treatment, precision targets the faulty BRAF gene jamming the signal that causes melanomas to grow uncontrollably. Blocking the activity of this gene can cause cancer cells to die and tumours to shrink. All cancers are different in their genetic properties and therefore patients respond differently to treatment. Vemurafenib presents an opportunity to personalise the treatment approach for metastatic melanoma.
Vemurafenib is not currently licensed and the diagnostic test for BRAF mutation is not currently commercially available. The pill, previously known as PLX4032 or RG7204, was recently filed with both the European Medicines Agency (EMA) and US Food and Drug Administration (FDA) who will review it over the coming months for licensing.
Dr James Larkin, UK Principal Investigator for BRIM 3 from The Royal Marsden, said: "Without question, the results of this trial represent a turning point in the treatment of this disease. Vemurafenib targets the faulty BRAF protein which is present in 50% of melanomas and this trial has shown that vemurafenib significantly prolongs life in comparison with chemotherapy".
Over the past twenty-five years, rates of malignant melanoma in Britain have risen faster than any other common cancer. It is now the second most common cancer in young adults (aged 15-34) in the UK, affecting almost twice as many young women as young men, although men are more likely to die from it.
Professor Richard Marais, whose work at the ICR demonstrated the importance of BRAF in melanoma, said: "This is the biggest breakthrough in melanoma treatment in more than 30 years. The results demonstrate for the first time that a targeted therapy can work in melanoma and will change our approach to treating this disease. It is an enormous advance in the field."
Further trials are underway exploring the use of vemurafenib in a variety of other cancers including ovarian, thyroid and colorectal cancer. In conjunction Roche and partner company Plexxikon have developed a diagnostic test to determine whether patients have the faulty BRAF gene, which could deliver results in a matter of days.
The most frequent grade 3 adverse events with vemurafenib were skin related and included cutaneous squamous cell carcinoma, a common skin cancer treated by local excision. Additionally, generally mild and reversible increases in liver enzymes (GGT, ALT, AST, alkaline phosphatase, and bilirubin) were observed in some patients.
The most common adverse events were rash, photosensitivity, joint pain, hair loss and fatigue.
Media Contact: Hannah Rhind from Roche on 01707 367 845 or 07884 116922 or ICR Science Communications Manager Jane Bunce on 0207 153 5106 or after hours 077217 47900
Notes to Editors:
Advanced Melanoma and BRAF
Advanced melanoma is the deadliest and most aggressive form of skin cancer. A person with advanced melanoma typically has a short life expectancy that is measured in months. There are an estimated 2000 deaths annually in the UK from malignant melanoma, with young people disproportionately affected by the disease. Over the last twenty-five years, rates of malignant melanoma in Britain have risen faster than any other common cancer. If current trends continue, it is anticipated that there will be around 15,500 cases of malignant melanoma diagnosed per year within the next 15 years. Until recently there has been no major advance in treatment for 30 years and patients with advanced melanoma have had very few treatment options.
The BRAF protein is a key component of the RAS-RAF pathway involved in normal cell growth and survival. Activating mutations in the BRAF gene cause this pathway to be overactive, which may lead to excessive growth and cancer. Mutations in the BRAF protein are found in about 50 percent of melanomas and it is estimated that approximately eight percent of all solid tumours contain BRAF mutations.
Vemurafenib is an investigational, oral medicine that is designed to selectively inhibit a cancer-causing mutated form of the BRAF protein. Vemurafenib is being co-developed under a 2006 licence and collaboration agreement between Roche and Plexxikon. A polymerase chain reaction-based companion diagnostic, the cobas® 4800 BRAF V600 Mutation Test, is being co-developed by Roche Molecular Diagnostics and Plexxikon in parallel to identify people whose tumours carry the BRAF V600E mutation. Vemurafenib is not currently licensed for the treatment of BRAF-mutated, advanced melanoma.
Roche in the UK
Roche aims to improve people's health and quality of life with innovative products and services for the early detection, prevention, diagnosis and treatment of disease. Part of one of the world's leading healthcare groups, Roche in the UK employs nearly 2,000 people in pharmaceuticals and diagnostics. Globally Roche is the leader in diagnostics, and a major supplier of medicines for the treatment of cancer, transplantation, virology, bone and rheumatology, obesity and renal anaemia. Further information at: www.rocheuk.com.
The Institute of Cancer Research (ICR)
- The ICR is Europe's leading cancer research centre
- The ICR has been ranked the UK's top academic research centre, based on the results of the Higher Education Funding Council's Research Assessment Exercise
- The ICR works closely with partner The Royal Marsden NHS Foundation Trust to ensure patients immediately benefit from new research. Together the two organisations form the largest comprehensive cancer centre in Europe
- The ICR has charitable status and relies on voluntary income, spending 90 pence in every pound of total income directly on research
- As a college of the University of London, the ICR also provides postgraduate higher education of international distinction
- Over its 100-year history, the ICR's achievements include identifying the potential link between smoking and lung cancer which was subsequently confirmed, discovering that DNA damage is the basic cause of cancer and isolating more cancer-related genes than any other organisation in the world
For more information visit www.icr.ac.uk
The Royal Marsden Hospital
The Royal Marsden opened its doors in 1851 as the world's first hospital dedicated to cancer diagnosis, treatment, research and education. Today, together with its academic partner, The Institute of Cancer Research (ICR), it is the largest and most comprehensive cancer centre in Europe treating over 44,000 patients every year. It is a centre of excellence with an international reputation for groundbreaking research and pioneering the very latest in cancer treatments and technologies. The Royal Marsden also provides community services in the London boroughs of Sutton and Merton and in June 2010, along with the ICR, the Trust launched a new academic partnership with Mount Vernon Cancer Centre in Middlesex. Since 2004, the hospital's charity, The Royal Marsden Cancer Charity, has helped raise over £50 million to build theatres, diagnostic centres, and drug development units.
Prince William became President of The Royal Marsden in 2007, following a long royal connection with the hospital. For more information, visit www.royalmarsden.nhs.uk or contact Belinda Payne on 020 7808 2107 or firstname.lastname@example.com