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Fischer Audio's FA-004 is a portable headphone for the budget-conscious audiophile on the go, or for one in need of a small, light weight solution for fun listening.
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Fischer Audio FA-004
TheWuss · May 12, 2010 · 3K
- Rating:
- 4/5,
Recent Reviews
Fischer Audio FA-004
Written by Ri888ff
Published Jan 26, 2014
- 4.0/5,
Pros - Look great, comfortable, loving sound
Cons - Lack of bass
Very pleasant sounding. Clean middle. Good price
Fischer Audio FA-004 - A gateway to hi-fi sound
Written by LFF
Published May 13, 2010
- 4.5/5,
Pros - Attrractive, light weight, comfort, PRICE!!!
Cons - Slightly boomy bass, lack of ambiant detail in recordingsFischer Audio's FA-004
NOTE***These are my subjective opinions and should be taken as such. I always recommend you listen for yourself before you decide to make a purchase.***NOTE
•› Frequency range: 20-20000 Hz
•› Sensitivity: 104 dB
•› Impedance: 32 Om
•› Input power: 180 mW
•› Length of a cable: 1.25 M
•› Colors available: black (Bk), brown (Br).
•› Includes: 6.3 mm jack adapter.
•Portable set-up: Sansa Clip+ (Rockboxed) ->UE Mini2Mini ->RSA Shadow
•Portable set-up: Ipod 5.5G -> ALO Cotton Dock -> RSA Shadow
•Home Rig 1: Sony D-25S -> UE Mini2Mini from Line out-> Heed CanAmp
•Home Rig 2: Denon DCD 1560 CD Player – RCA -> Heed CanAmp
•My mastering rig
After reading a few reviews about Fischer Audio I couldn't help but to feel curious and take the reviews with a grain of salt. However, the temptation was a bit too strong so I contacted Fischer Audio through another reviewer and to my surprise, Fischer sent me a box of their products for me to listen to.
On first glance the FA-004 looks like another OEM product you might find at Fry's. The packaging is simple and it serves it purpose.
Once you open the packaging you will find the headphones with an attached adaptor.
The look of the FA-004 is pure retro. It looks like those old elementary school phones you would use during certain English exercises or when listening to things at the library. In my opinion, the look is awesome.
1.Paul Simon – You Can Call Me Al from the album "Graceland"
The sound is pleasing. The soundstage is quite large and the bass is pronounced. Good detail.
2. Paul Simon – Homeless from the album "Graceland"
The voices sound natural. The ambiance is there and the soundstage is very good. The baritones come out a bit more.
3. Nat King Cole – Stardust from the DCC release of "Love Is The Thing"
Nat's voice sounds natural, the strings are as airy as they should be but they aren't bright or suppressed. The sound is very pleasant.
4. Danny Elfman – This is Halloween from the soundtrack "Nightmare Before Christmas"
The voices are all distinct. Bass is very nice. The soundstage and imaging on this track is better than most.
5. Absolute Silence – custom demo track made by myself.
Except for a slight pop the Clip+ added when the track finished, it was completely dead silent for the entire duration of the track.
6. Bach – Solo Cello Suites from the Mercury Living Presence release feat. Janos Starker
The cello sounds ever so slightly boomy. The ambiance and detail is present.
7. Ella Fitzgerald – Sweet & Lovely from the album "Sings Sweet Songs For Swingers"
Nice. Ella comes across rather natural and a bit more upfront. The bass is really showcased here and the soundstage is once again very nice. Imaging is superb. Very airy but not exaggerated.
8. Red Hot Chili Peppers – Californication & Scar Tissue from the album "Californication"
The bass is really shining through. The distortion and clicks can be heard but are not as clear as they should be.
9. Lady Gaga – Poker Face from the album "The Fame"
The bass is awesome without being over-powering or bloated. Vocals are also very nice. The detail is present as well.
The one thing I noticed while listening to the FA-004 is that it does well with all types of music. It sounds similar to the Enigma IEM but with more authority across the entire range and superb imaging. The bass is pronounced yet the FA-004 has more accurate and articulate bass than your average headphones this size. It really shines with all tracks but especially with rock, pop and hip-hop. Like the Enigma, it has a very pleasing and fun sound signature. While the FA-004 definitely isn't a transparent headphone, it is very, very pleasing while still retaining an over-all natural sound signature. Is it a monitor grade headphone? No. Is it near monitor grade? YES!
One of the most difficult things I find is describing the exact thing I am hearing because sound is so subjective and so intangible. The sound signature of the FA-004 is fun but natural. Imagine what an RS-1 and HP-2 would breed if they had a child that was adopted by the HD-600 and you have the sound of the FA-004. Complicated? Yes, I know. Let me dive into this further with the help of Frank Sinatra.
The CD pictured above is one I cherish for it's sound quality. One of the best, if not the best official Frank Sinatra release you will find. The prices on Amazon are also great! Now, let's cue up track 11, "Love & Marriage". This track has some nice bass in the intro and Frank's voice is fabulous. On the HP-2's, it's just pure mellow and warm magic. Same with the HD-600's, just a little less warm with Frank a bit more up front. With the RS-1's, you get quite a bit more hiss and a slightly leaner sound. With Fischer Audio's FA-004 you get a warm sound with a tad of hiss and a slightly more forward sounding Frank Sinatra. The FA-004 certainly doesn't have such an open sound as the above headphones but you have to consider that the FA-004 IS NOT an open design. It's certainly has better isolation that the above headphones but then again consider it IS NOT an open design. They are very comfortable for me and they isolate extremely well. My wife is not a deep sleeper and wakes up at the slightest of noises. I was listening to all types of music, about 3 feet away with the FA-004's late at night and she never once woke up! For me, that alone makes these worthwhile!!!! Married guys…I know you understand this part.
Now, using the same CD, let's cue up track 13, "How Little We Know". The track starts out with an outtake. With the HP-2, the sound is warm and natural with almost no hiss. The HD-600 also gives out a natural sound with a wee bit of hiss. The RS-1 definitely lets you know that there is a tape playing as the hiss is all too noticeable. The FA-004 gives the natural presentation of the HD-600 with a hiss level between the HD-600 and RS-1.
If anything, for me at least, the above suggests that the FA-004 is a natural sounding dynamic headphone with a slight emphasis on the bass and highs. This give the FA-004 a very fun natural sound with a good sense of space and soundstage which only confirms my initial impression using the track "Homeless" from Paul Simon's album "Graceland".
For being a full size headphone, it did sound quite good without an amp – much better than the HD-600 or HP-2 un-amped. Plugged straight into my ipod or clip+, the sound was quite satisfying. However, I would highly recommend it be used with an amp to bring out its full potential. With an amp, the bass becomes tighter and more articulate and the entire frequency range plays with more authority and a clear, fuller body. When it was plugged into the Heed CanAmp, the synergy between the FA-004 and the CanAmp made for an eventful night of pleasurable listening. I listened to about 4 albums from first to last song with a big smile on my face. With the RSA Shadow the sound was just as impressive. Not quite as much synergy as with the Heed but still amazing considering its portability and power.
Not surprisingly, I found that these headphones upscale quite nicely as you move up the equipment chain. They sound great straight out of my ipod. They sound better on the Denon DCD 1560 CD Player going through the CanAmp and really impressed me coming out of my mastering rig. Not shabby at all!!! Certainly better than some Sony headphones I own that cost double the amount these do!
Once some of you handle the headphone and see it, you might think it's a cheap quality headphone. I have had a few comments from people who have seen the one I have. I think the looks are subjective but if you are in the "cheap looking" camp, I urge you to reconsider owning this headphone as the sound quality it puts out is certainly not cheap at all. I would never have imagined that a headphone with this sound quality would be in the sub $100 market. That's right…under $100.00 USA!!!!
So...considering everything, do I have any problems with the FA-004? YES. THE ONLY PROBLEM I FOUND: The included 6.3 mm jack adapter wasn't working so well. Easily fixed and frankly, I could care less if the jack adapter broke considering the great sound these put out.
Once again what gets my attention with Fischer Audio's products is the price/performance ratio. All the prices I was able to find for these were under $80.00 US! If I had paid $150 for these, I wouldn't be upset at all. I really do think these would be a good deal at $150.00. At $80 or under, these are an amazing deal. Just look at the headphones I was comparing them to and the difference in price! If anything, these could be the new entry level to high end sound and for many outside of head-fi'dom, probably an end point as well.
A really fun budget portable headphone
Written by TheWuss
Published May 12, 2010
- 3.5/5,
Pros - attractive, light weight, comfy, great mids, affordable
Cons - rolled off sub bass, less than realistic treble
The Fischer Audio FA-004 is an enigma wrapped in a riddle, wrapped in an enigma.
This Russian headphone has just garnered attention recently in the Western world. And, with a selling price of $67 at Bugden Audio, it should hopefully take off as a really viable option for someone looking for a portable, nice sounding set of closed cans at a budget price.
So, what does this cheapy set of cans sound like? Well, that's the enigma. They are smallish, barely-circumaural cans. And, as a result, they simply aren't able to convey the nuances of more expensive and more full-size headphones. But what they do offer is a sound signature that is tuned to give you a lot of enjoyment. A sound signature that does a pretty good job of disguising its own shortcomings. Which are a significant roll-off in the lowest frequencies, and a slightly thin and less than realistic-sounding treble.
These headphones are fairly forward in the mids, and fortunately they have pretty nice sounding mids as well. They have a slight mid-bass bump to compensate for not reaching those lower frequencies mentioned. Using the "Heartbeat" track from the headphone test album "Open Your Ears", the final low frequency heartbeats are barely there, with the headhpones giving only the initial impact of the bass note, and hinting at its sustain and decay.
Another enigma about these FA-004 is that, for a closed headphone, they feel surprisingly open. They don't have strong clamping force, and don't create a strong seal when worn. This combined with their light weight makes for a really comfortable headphone that doesn't sound closed off, and doesn't create tons of pressure within the ears.
The imaging and soundstage are both pretty average, but certainly better than any other sub-$100 headphone I've ever heard.
At $67 plus shipping, these really do represent an astonishing value. They've become the headphones in my work rig, and I'm enjoying them immensely. They're such a value that they have piqued my interest in their bigger siblings, the FA-002 and FA-003...
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Liberty Of The Seas
Liberty Of The Seas
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"Living the Dream"
My neck hurt stretching to look at the very top of the ship as it waited for its passengers to board her at Barcelona, Spain. She looked so majestic and inviting glistening white. Liberty of the Seas was about to make my dream come true. This maori girl from way down-under in New Zealand was about to embark on an adventure of a life time. I was travelling alone but never once did I feel at all lonely or friendless. I had been thoughtfully placed at a dining table with just the right guests who eagerly met each evening to share the stories of the day. Each of us were interested in the on shore excursions of the other. We would wish we had time to do them all. We couldnt wait to see what was on the menu for the night and our lovely attendants would serve us sooo patiently, with such respect and grace the yummiest of meals. I was then ready to scurry off to the featured show of the evening and then make my way to enjoy the piano bar entertainment. I had my regular seat by the end of the cruise.There was soo much to choose from I could never make up my mind at times. Oh and then the midnight snack bars..eventually they would see me coming and would have my 'regular' snack on the counter ready for me. But wait theres more.. my bed (which I unfortunately hardly slept in) was devine and my cabin overlooking the promenade was the best choice over a porthole. Believe it or not but I would find a different animal in my cabin every night. Either a monkey hanging from the ceiling to an elephant on my bed who would turn into a fluffy white towel in the morning for my shower.Saying goodbye to my gracious attendant Irene was difficult the last morning. Did I enjoy my week long cruise of a lifetime? From education and history lessons in Rome, to a romantic island trip to Capri and beautiful sunsets viewed from the decks of the ship. I lived the dream that became reality!Every day I pinched myself to check if I was awake or asleep and wasnt dreaming! You betcha I loved my cruise!Read more
- Cruise Name: Liberty Of The Seas
- Destination: Mediterranean
- Sailed: June 2011
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"Fantastic from start to finish!"
What an amazing holiday! It was only a 5 day cruise but there was so much to do and see. We boarded at Barcelona and stopped at Ville France and Palma. Breath taking views.The staff were extremely friendly and the food was amazing. Entertainment at night was 1st class -full size ice skating rink! Frank Sinatra evenings plus a full stage show of Saturday night Fever. Cruising is the only way to travel. Have booked my cruise for next year already!Read more
- Cruise Name: Liberty Of The Seas
- Destination: Mediterranean
- Sailed: May 2011

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Athletic Training Club: A community of athletic training student dedicated to enhancing and sharing their knowledge of athletic training with each other and with the community.
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Grizzly Pride Alliance: G.P.A. exists on the Franklin College campus to bring awareness, education, support, and social opportunities for students who identify as Gay, Lesbian, Bisexual, Transgender, Questioning and all Allies of the community.
Student Association in Support of Multiculturalism: S.A.S.O.M. is an organization that promotes diversity and cultural celebrations, by providing opportunities for friendship, understanding and learning.
Wave 3: Increases awareness of women's issues, to secure a more egalitarian campus and community and to promote intelligent and amicable discussion of women's issues that exists internationally, nationally and locally.
Drama Club: Drama Club is devoted to supporting and promoting theatre on campus and in the community as well as providing opportunities and recreational activities for its members.
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Intercultural Book Club: The Intercultural Book Club is an informal gathering of faculty, staff and students to discuss books that deal with intercultural issues such as the concepts of race, gender and belonging.
Intervarsity Christian Fellowship: Their goal is to follow Jesus as Savior and Lord: growing in love for God, God's word, God's people of every ethnicity and culture and God's purpose in the world.
Intramurals: Franklin College intramural sports present students with the chance to get the most out of their athletic abilities.
Residence Hall Association: Members of the Residence Hall Association promote getting to know your neighbors, abiding by all college policies and speaking out when problems arise within the residence halls and on campus.
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Student Entertainment Board: S.E.B. collaborates with the Student Activities Center in sponsoring campus-wide events and traditions, both on and off campus.
World Cultures Club: World Culture Club promotes diversity by organizing and participating in activities that have social, cultural and intellectual value.


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Opinion: Egypt's Security State Rises Again
Hoover Institution senior fellow Fouad Ajami on the Egyptian government's ban of the Muslim Brotherhood.
This transcript has been automatically generated and may not be 100% accurate.
... I ... the knee Egypt where the military led government their ban the Muslim Brotherhood ... after a series of attacks and violence is now starting to spread ... to some of the urban centers ... what is the reaction you're going to be are we seeing the rise of the security state ... again in Cairo ... Hoover Institution Senior Fellow Fouad Ajami stays with me now ... if the line is this a return ... to move the days of the bar ... it isn't exactly suited to the security state ... and this idea that you can ban the Muslim Brotherhood this idea that you can designate the Muslim Brotherhood ... terrorist organization ... it's almost like borrowing except from the wee wee wee wee list ... groups ... as on the terrorism list ... the Western button has deep roots in the system we don't have to be with us to be friends of the Wilson Brotherhood ... this has eight decades behind it ... millions of people belong to the Wilson Brotherhood ... deep Netflix who went three ... other fed and taken care of them sometimes ... so you dream you had this dream of an agent with the AIDS ... and without sales and this is a false dream I think would be good to see ... them doing that we could all couldn't general CC have sent to the Egyptian people walk ... in the real Kevin track is al Qaeda in the Sinai ... if you ... protest peaceful Muslim Brotherhood will take you into the political process again was an ... option for when he needed the advisors could have succeeded ... in that this a good advice ... but I think Joe says he has begun to relieve his own press ... the majors he's in the team in Egypt Jesus even of Egypt ... and the state of Egypt now has declared war on the Muslim Brotherhood ... the Muslim Brotherhood need Titanic mistakes weren't in the year when you empower ... this declaration of the Brotherhood is a terrorist organization ... does not sold economic ... and sociological and the problems of the justice I pushed the Brotherhood it warrants groups like al Qaeda in the Sinai and get them ... in some ways force them to cooperate with one another lucrative rather than the two options you can compete in the ... process you can play the ... game and they would let the men's under Mubarak been doing a lot of them to compete ... for seats in the Parliament ... to consider for the game when you ... can become the tenth position ... in the choices can ... a minute left what influence if any this United States ... I think ... lil precious little Andrew Sullivan was discussing ... been with two minutes ago I'd I just think if you want to play the game ... if you want to shape the politics of other nations in you which ... you have to be on the ground you have to care ... and I think we have made it clear ... to the people in the Mideast oh we


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Explore Our Hotel
Welcoming Madrid hotel with free WiFi and an included breakfast
Holiday Inn Express® Madrid Alcobendas hotel is located off the A1 motorway, which connects to the M30, M40 and M50 ring roads. There's free parking on-site, and Madrid–Barajas Airport (MAD) is just a 10-minute drive away. There's a bus stop right outside and La Granja Metro Station is 15 minutes away by foot.
The Spanish capital's exciting attractions are all within easy reach. Gaze at masterpieces at Museo Nacional del Prado, indulge in an evening of opera at Teatro Real. At night, discover Madrid's vibrant tapas scene. Retail outlets like Diversia, Plaza Norte and IKEA are all easily accessible.
With its convenient location in the Alcobendas Business Park and speedy airport access, Holiday Inn Express® Madrid Alcobendas hotel is a great base for business travellers. The hotel is ten minutes' drive from events venue IFEMA Feria de Madrid. Guests also have access to a 24-hour Business Centre and two naturally lit meeting rooms.
Get set for the day with an included Express Start Breakfast of continental items. Ask the friendly staff for local restaurant recommendations. Then, settle down for a peaceful night's sleep in a cheerful room equipped with free WiFi. Family rooms are available.
- Crib Available
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- Hair Dryer
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In-Room Features
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- Connecting Rooms Available
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Esquina Calle Metalurgia 1-3 Alcobendas
Madrid, 28108
Check In: 2:00 pm
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Working with the surface tissue, promoting relaxation and all around well-being by using gentle strokes improving circulation and flush the toxins out.
Deep Tissue
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Pregnancy massage – no deep work and very gentle relaxation.
Trigger Point
Hot Stone
Hot stones are heated to about 150 degrees. Rocks vary in size depending on area of the body they are being used on. This technique is used to loosen up tissue before massage. (Additional $20)
Couples Massages
Receive a massage with your loved one. (Additional $5 per person)


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2014 Amgen Tour of California Media Credential Application Now Available
Published on Feb 26, 2014
The media credential application is now available online. Applications to be considered for media credentials and/or a photo moto can be found on the media resources page on the tour website.
The media credential application for the 2014 Amgen Tour of California is now available online. Applications to be considered for media credentials and/or a photo moto for the 2014 Amgen Tour of California can be found on the media resources page on the tour website. A completed media credential application does not guarantee access and confirmations will be issued via email.
- Freelancers must submit an assignment letter issued by the news organization they are representing to email@example.com in addition to filling out the online application form. Only freelancers with a valid letter of assignment will be considered for media credentials.
- Credential applications will be reviewed and confirmations will be issued via email. Credentials will be distributed at the start and finish lines of each stage and CANNOT BE MAILED. Press room locations will be posted in the media resources section at www.amgentourofcalifornia.com in May.
- All photography and video footage is to be used exclusively as news coverage. Photography and video footage gathered for commercial use must be sub-licensed through the race's organizers, AEG. Any photography or video footage used in a commercial way without prior approval will be subject to penalties, enforced through legal or arbitration means.
- Placement in media vans is at the discretion of race organizers and will be determined on-site.
- Photo Motos: As photo motos are very limited, not all requests can be granted. A separate application, which can also be found at the link below, must be completed to be considered for a photo moto. For those who are approved to utilize a photo moto, a daily fee of $250 per moto, per day will be assessed, which includes a driver. A valid credit card number must be entered once the application has been approved. All approved applications will be charged an initial refundable deposit of $250, which will be credited to cover the first day of use. Additional charges will be assessed throughout race week. Each photographer will be required to provide his or her own helmet and appropriate riding gear.
About the Amgen Tour of California
The Amgen Tour of California is a Tour de France-style cycling road race created and presented by AEG that challenges the world's top professional cycling teams to compete along a demanding course that traverses hundreds of miles of California's iconic highways, byways and coastlines each spring. The teams chosen to participate have included Olympic medalists, Tour de France contenders and World Champions. More information is available at www.amgentourofcalifornia.com.
About Amgen
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.
Amgen focuses on areas of high-unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be the world's largest independent biotechnology company, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. For more information, visit www.amgen.com and follow us on www.twitter.com/amgen.
About AEG
AEG is one of the leading sports and entertainment presenters in the world. AEG, a wholly owned subsidiary of The Anschutz Company, owns or controls a collection of companies including facilities such as STAPLES Center, StubHub Center, Sprint Center, The O2, Nokia Theatre L.A. LIVE and Best Buy Theater Times Square; sports franchises including the Los Angeles Kings (NHL), two Major League Soccer franchises, two hockey franchises operated in Europe, management of privately held shares of the Los Angeles Lakers and the Amgen Tour of California cycling road race; AEG Live, the organization's live-entertainment division, is a collection of companies dedicated to all aspects of live contemporary music performance, touring and a variety of programming and multi-media production. For more information, visit AEG today at www.aegworldwide.com.
# # #
Media Contacts:
Diana Valdez, GolinHarris


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May all things be restored in Christ in a world that has forgotten Him, and even in a Church that undergoes its own Passion. The only way to restore Order to society is to restore Christian Civilization. And this can only occur when our Church is again restored to its former glory and men are willing to lay down their lives for the fullness of the One, True Faith.Read more >>
Regarding their canonical status:
The call of Pope Benedict XVI for a robust rediscovery of the traditional Latin liturgy and consecrated life is at the heart of our foundation, a cause which finds renewed urgency under the reign of Pope Francis. We lead a vowed life of common prayer totally immersed in the traditional Latin rite and the traditional expression of the Catholic Faith.
We assist our local diocese in caring for Catholics who are devoted to the old liturgy as well as help others to discover its great strength and beauty. Our mission of prayer seeks to bring back to the Faith lukewarm and fallen-away Catholics as well as to convert non-Catholics to the One True Faith.
Common Prayer
Our community begins its day in Grand Silence, which does not end until after the chanting of Prime (our morning prayer) to ensure a spirit of recollection. The community daily assists at the traditional Latin Mass either at the parish or in our House chapel, and also chants Vespers and Compline daily according to the ancient Roman rite.
Brothers who are not bound to recite the full Divine Office are encouraged to recite the remainder of the day's prayers from the Little Office of the Blessed Virgin Mary.
Other traditional prayers are interspersed throughout the day. The old Roman meal blessing is chanted in full at common meals. The Angelus is prayed in Latin, chanted on feasts of Our Lady. Chanted Vespers of the Dead is often added to Vespers of the day.
Brothers are also expected to pray at least five decades of the Holy Rosary each day and to devote themselves daily to meditation.
Our community ministers at Mother of Divine Mercy Parish in Detroit teaching catechism and training altarboys to serve at the Traditional Latin Mass. The community also has engaged in door-to-door inner city evangelization and catechetical home visitation. Brothers, who wish to discern the priesthood, enroll in priestly studies at Ss. Cyril and Methodius Seminary at Orchard Lake.
Our community at St. Thomas Aquinas House is privileged to enjoy the official endorsement of the Archbishop of Detroit as a non-juridical private association of men under formal ecclesiastical review by the Archdiocese of Detroit. The Archbishop has granted us his full permission to live our religious life according to the Statutes we have submitted to him, to call our community 'Catholic,' and to take private vows of religion.
The proposed name for our community is 'Canons Regular of St. Thomas Aquinas,' though this is not yet official. We began our discernment in August 2012 at the invitation of Bishop Francis Reiss, one of the auxiliary bishops and vicar general, and with the generous help of the local Office for Consecrated Life. We aspire to become a priory 'sui iuris' of diocesan rite which will pray and offer ministry totally devoted to the extraordinary (old Latin) form of the Roman liturgy, thus placing us also within the purview of the Pontifical Commission 'Ecclesia Dei.'


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I made cookies for my Dad's dental office for a lot a years and these oatmeal cookies always seemed to be a favorite.
Oatmeal Cookies
1/2 cup butter, room temperature
1/2 cup shortening
1 cup brown sugar
1 cup granulated sugar
2 eggs
2 teaspoons baking soda
1 teaspoon salt (I like a heaping teaspoon)
1/2 teaspoon baking powder
1 tablespoon vanilla
2 1/4 cup all-purpose flour
2 cups old fashioned oats
Cream together sugars, butter, and shortening. Add eggs one at a time and beat until light and fluffy. Add baking soda, salt, baking powder and vanilla. Add flour and oats and mix until incorporated. Place balls of dough on a cookie sheet lined with parchment paper and bake at 350 degrees F for 10-12 minutes.


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Effective date: April 1st, 2015
These Edmodo Spotlight User Terms of Service ("Spotlight User Terms") apply to your use of Edmodo's Spotlight service ("Spotlight") and any Teaching Content (defined below) therein. Your use of Edmodo's Services (which include Spotlight) is also at all times subject to Edmodo's Terms of Service(the "Terms of Service"), which are incorporated into these Spotlight User Terms by this reference. In the event of any conflict between these Spotlight User Terms and the Terms of Service, these Spotlight User Terms shall prevail with respect to the subject matter of these Spotlight User Terms.
Who is eligible to purchase Teaching Content on Spotlight?
You may only use Spotlight to purchase or obtain digital downloads ("Teaching Content") offered by third parties ("Content Providers") if you are (a) a registered user of Edmodo and (b) at least eighteen (18) years old.
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Some Teaching Content is offered for free, but some is offered for a fee. The fees are determined by the individual Content Providers. If you wish to purchase any Teaching Content, you must provide Edmodo with accurate payment information, as requested by Edmodo. Information that you disclose to Edmodo by using Spotlight (including billing information) is covered by Edmodo's Privacy Policy. You understand and agree that if you don't provide us with the billing information we request, or if you don't keep that information up-to-date, we may not be able to complete your transaction(s) – and you won't be able to download Teaching Content if a transaction cannot be completed. Sorry – there are no refunds for Teaching Content. All Teaching Content prices are listed in U.S. Dollars. Please keep in mind that Edmodo just facilitates the transaction between you and the Content Provider, and that Edmodo isn't the party creating or selling the Teaching Content.
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The Teaching Content is not sold or licensed by Edmodo, but rather by the applicable individual Content Provider. Each Content Provider may have certain restrictions on your use of the Teaching Content, in addition to these Terms; if there are any such additional terms, they will be stated in the listing for the applicable Teaching Content, and you must abide by all such restrictions. In addition to any restrictions imposed by the Content Provider, as a condition to use Spotlight, Edmodo requires you to: (i) use the Teaching Content only for your non-commercial, educational use; (ii) only distribute the Teaching Content to students who are currently enrolled in courses you teach ("Students"); (iii) not transfer the Teaching Content to any other teacher or administrator without the permission of the Content Provider; and (iv) use reasonable efforts to ensure that your Students don't use the Teaching Content for anything other than their own non-commercial, educational use. Any other applicable restrictions set forth in the Terms of Service also apply to your use of the Teaching Content (except to the extent these Spotlight User Terms conflict with the Terms of Service, as described in the introductory paragraph above).
We use the term "Content Provider" in connection with the Teaching Content, but you understand and agree that you are not purchasing the underlying copyright or other intellectual property right in the Teaching Content, but rather only the single copy you have downloaded (subject to any applicable license restrictions required by the Content Provider and the restrictions set forth in these Spotlight User Terms).
Edmodo cannot guarantee, and is not responsible in any manner for, the quality or accuracy of the Teaching Content or the listing for the Teaching Content. For clarity, the disclaimers and limitations on Edmodo's responsibility and liability for products or services offered by a third party that are described in the Terms of Service apply to Teaching Content and your interactions with Content Provider. If you are unhappy with the Teaching Content for any reason, please contact the applicable Content Provider, in accordance with Section 4 below.
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If you do post a review, you grant Edmodo a nonexclusive, royalty-free, perpetual, irrevocable, and fully sublicensable right to use, reproduce, modify, adapt, publish, translate, create derivative works from, distribute, and display such content throughout the world in any media, and you grant Edmodo and any sublicensee the right to use the name that you submit in connection with such content, if they choose. You represent and warrant that you own or otherwise control all of the rights to the content that you post and that the content is accurate. Edmodo takes no responsibility and assumes no liability for any content posted by you or any third party.


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Welcome to Citizens Bank Website. We are honored that you have taken the time to visit our website and trust you will find everything you need!!
Citizens Bank is a locally owned independent community bank established in 1919 and has operated continuously in Marshall County, Mississippi since its inception. Our main office is located in Byhalia Mississippi with branches in Barton and Victoria Mississippi. As a locally owned Community Bank, we are able to provide you with quick decisions and a personal service that is outstanding! We believe that the most important asset we have is our customers. Our products are designed, our hours are set, and our employees are hired to meet the needs of our customers. High quality customer service is an ongoing vision of Citizens Bank.
At Citizens Bank we appreciate our valued customers and want to thank each of you for your business. Please give us a chance to earn your business and experience our personal service. Feel free to stop by or call any of our local branches today.


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Babe Ruth Baseball Sign-ups this week
South Tahoe Babe Ruth Baseball is holding signups for the upcoming season Tuesday and Wednesday at the Kahle Park Recreation Center from 6 – 7:30 p.m. Additional signups will be held Thursday at the South Tahoe Ice Rink from 6 – 7:30 p.m.
All boys and girls ages 13 – 15 are welcome to signup. Players must have a birth date between May 1, 1997 and April 30, 2000. The cost is $100 per player.
Babe Ruth is a competitive South Shore league that focuses on continued baseball skill development, sportsmanship and team camaraderie in a fun and safe environment. Anyone interested in playing, helping coach or assisting the league should try to attend one of these sign-ups. For more information, please contact, Eric Eymann, Player Agent at (530) 721-2113 or by email at email@example.com.


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DV Mark DV40 112 40W 1x12 Tube Guitar Combo Amp
Sku #H74138000000000
DV Mark
Tube Combo Guitar Amplifiers
- Write a Review
45 day price guarantee, 45 day return policy, 100% secure shopping
Its tonal options are almost endless thanks to DV Mark's patent-pending Continuous Power Control.
The DV Mark DV40 112 is a two-channel, 40W, all-tube combo with patent-pending Continuous Power Control, Accutronics reverb, and an EL34-equipped power section that delivers great clean tone on channel 1 and rich tube saturation from channel 2.
Tonal options are almost endless thanks to DV Mark's patent-pending Continuous Power Control (CPC), which allows you to change the power incrementally from the full 40W (Class A/B) all the way down to 1W (Class A) in pentode mode; or 15W (Class A/B) to 0.5W (Class A) in triode mode.
Plug into the DV40 112 combo and you'll immediately hear its quality: very clean sounds even at high volumes, great crunchy rhythm tone, rich saturation, boost switch for lead playing, balanced response in all frequency ranges and impressive bass response. The range of tonal options is incredible, and it's easy to find your own sound quickly using EQ and the very practical CPC feature.
The DV40 112's other optional patent pending feature is the Advanced Tube Control System, which allows users to connect the amp to a computer, and-using custom software-collect technical data and tube parameters from the amp.
- Power output: 1-40W (pentode mode), .5-15W (triode mode)
- Preamp tubes: 2xECC83
- Power tubes: 2xEL34, 1xECC83
- Two channels
- Controls: Gain, Master, Presence, Bright, Solo, Continuous Power Control (CPC)
- 3-band passive EQ
- Accutronics spring reverb
- Low/High bias switch
- 4-, 8-, and 16-ohm speaker outs
- 12" B&C neodymium speaker, custom-made for DV Mark
Everything from shimmering cleans to saturated distortion, with controls to custom-tailor whatever sound you want! Order now.


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PBA Unveils New Look, Logo, TaglineSeptember 4, 2012
The Professional Beauty Association is rolling out a new look, logo and tagline as part of its newly unified association and direction. PBA members and the salon industry are starting to see fresh, cohesive visuals along with PBA's new tagline: Advancing OUR Industry.
The new direction is part of an enhanced marketing and branding campaign designed to unify the various aspects of PBA's mission.


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|Thu 25 Oct 2012, 7:30pm
An unmissable night of Music, Theatre and Comedy. In a woolshed...
Following their sold out tour of the South Island earlier this year, CMP/Riverlands Presents: The Bitches' Box and Mel Parsons Tour 2012 - heading North to a farm near you this October & November.
Join us for a world-class show in a rural setting, as singer/songwriter and two-time Tui Award finalist Mel Parsons kicks off the night with songs from the heart, followed by a hilarious romp around the kennels as actresses Amelia Guild and Emma Newborn tell you a dogs tail...all the way from The Bitches' Box.
Running times:
6:30 pm - Cash bar open, Fundraiser BBQ Dinner, door sales (if avail)*
7:30 pm - Show starts - Mel Parsons
8:15 pm - Intermission
8:45 pm - Show resumes - The Bitches' Box
BBQ dinner from 6:30pm - fundraiser supporting Haumoana School.
Due to limited capacities at venues, purchasing online pre-sale tickets is strongly recommended. Door sales will be available on the night, if not sold out prior.
*Please note that there are no eftpos facilities onsite for bar, BBQ or door sale purchases - cash only.
Before you go, would you like to subscribe to our free weekly newsletter with events happening in your area, competitions for free tickets and CD giveaways?
No thanks - I'm already an Eventfinda member (or I don't want to join)
Enter your email below, click on the Sign Up button and we'll send you on your way
Continuing confirms your acceptance of our terms of service.


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* FTSEurofirst 300 down 0.3 pct, Euro STOXX 50 up 0.1 pct
* Novo Nordisk hits U.S. hurdle, Sanofi rallies
* Full-year trend remains up
By Francesco Canepa
LONDON, Feb 11 (Reuters) - European shares dipped on Monday as sharp falls in pharma group Novo Nordisk outweighed rallies in rival Sanofi and Dutch retailer Ahold.
Shares in Novo Nordisk fell 12 percent in volume nearly 5 times their average for the past 90 days as U.S. regulators requested additional tests on the firm's new insulin drugs, in a move that could delay approval by some years..
The stock knocked 1.7 points off the FTSEurofirst 300, which was down 3.9 points, or 0.3 percent, at 1,158.93 points at 1136 GMT.
Rival Sanofi rallied 4.3 percent as its own insulin drugs would not face competition from Novo Nordisk's products.
Ahold was also up 4.3 percent to 11.1 euros, after the retailer sold its 60 percent stake in Swedish supermarket chain ICA for about $1.3 billion dollars, close to the high end of analysts' price range.
Shares in the Dutch group were breaking technical resistance at their 2012-13 top and heading for a test of their 2007 high at 11.4 euros.
"Ahold was dead money for 5 years, but it should start to see some momentum building from here," a senior trader in London said. "The consolidation will be complete once we get through the 2007 top."
Technical charts on the euro zone Euro STOXX 50 index, up 0.1 pct at 2,633.03 points, also pointed to some upside in the coming weeks after a 4 percent drop in the previous ten sessions.
The index closed above its 200-week moving average at 2,616 on Friday and above a top tested twice in 2012 at 2,611.
Valerie Gastaldy, head of Paris-based technical analysis firm Day-By-day, expected the index to make a new high for the year at around 2,790 points in the next few weeks, adding any dip towards 2,611 in the meantime could be a buying opportunity.
The Euro STOXX 50 has come under pressure in the past two weeks as a corruption scandal stirred fears of political instability in Spain and the Italian election race became tighter, fuelling some profit-taking after a 37 percent rally since June.
Europe equity funds recorded modest outflows in the week ending Feb. 6, EPFR Global data showed, and net inflows into U.S. funds invested in European equities slowed markedly.
"Investors took a pause from the recent strong buying, but sold only an insignificant $200 million from European equity mutual funds," Nomura's research analyst Mark Diver said in a note.
"Our European equity mutual flow indicator ... is just shy of the 2-year peak in sentiment reached last week."
He added Nomura's flow-based indicator showed mutual fund investors are now at their most optimistic in the index's 10-year history, apart from two periods between February and March 2000 and April to May 2006, which were followed by market declines in the following weeks.
But fund managers expect the rotation into higher-yielding assets to continue as the global economic picture improves, helping equities resume their rally after a small pullback.
The MSCI Euro zone index offered prospective returns this year roughly 9 percent higher than Germany's 10-year sovereign bond, Thomson Reuters Datastream data showed.
The European earnings season has so far been mixed. With a quarter of it gone, 40 percent of companies in the STOXX 600 Europe index that have reported have missed consensus estimates, Thomson Reuters Starmine data showed.


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Now you can keep those lasting personal memories of your CHELSEA moments alive for ever with our great range of Memorabilia, Framed Pictures & Personalised Gifts.
A great personalised gift for you or someone you know to treasure. Our uniue collection includes Personalised Dressing Room Photos, Personalised Match Day Magazines, Personalised & Autographed Player Photos & Personalised Mugs.
Prices from just €12.99 + P&P
See our complete range of products by clicking on a product image below and selecting your chosen edition.
www.memorabilia.ie and www.sportsgiftshop.co.uk are leading suppliers of Personalised Sports Gifts & Memorabilia. If we have not listed a product that you require please feel free to contact us and we will do our utmost to supply your needs. All crests and logos are copyright of their respective owners.


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La Cornue CornuFé 110 Hood. Suzanne Kasler Collection, Blanc
Select Finish:
- Vendor Shipped
Easy, hassle-free returns online and in-store for eligible items.Learn More
Earn 5% Back in rewards4 plus free standard shipping3every day when you shop with your Williams Sonoma credit card at Williams Sonoma.Apply Now Learn More
- Summary
Complete your La Cornue CornuFé 110 range with a hood befitting its timeless, elegant style. The chimney hood is crafted to meet impeccable performance standards, with a powerful, four-speed blower to efficiently remove cooking smoke and odors, and halogen lighting to illuminate the cooktop.
- Coordinates with La Cornue CornuFé 110 Range, Suzanne Kasler Collection, in Blanc.
- Four-speed variable motor.
- Remote control and in-hood activation controls.
- Three 20W high-intensity halogen lights.
- Blanc nameled-steel finish with accents in choice of Stainless Steel and Polished Brass or Stainless Steel and Satin Chrome.
- Dimensions & More Info
- 43 1/2" x 25 1/2" x 27 1/2" high.
- Telescopic flue cover extends to max. height of 39 1/4".
- 120V, 60Hz, total rating: 425W, 3.6A.
- 176 lb. 10 oz.
More Information
- Includes one 600-CFM blower; unobstructed air flow with 6" duct.
- Includes two dishwasher-safe baffle filters with grease-capture system.
- Recirculation kits are available from vendor.
- This product is intended for use in the United States and Canada and is built to United States electrical standards.
- No assembly required.
- Five-year manufacturer's warranty.
- Made in Italy.
- Shipping
Shipping Information
This item will be shipped directly from the manufacturer and is not eligible for rush shipping. Please allow one to two weeks for delivery.
Shipping Rates
The shipping rate varies depending on your order total and shipping destination. View Shipping Options and Charges.
Return Policy
At Williams Sonoma, we take great pride in the quality and craftsmanship of our products. Attention to design, materials, safety and construction are our priority. Upon receipt, please inspect your purchase and notify us of any damage; we will arrange for a prompt replacement.
If within 30 days, you are dissatisfied for any reason, you may return your purchase for a refund of the merchandise value. An original receipt or gift receipt is required for all returns and exchanges. Returns with a gift receipt will be refunded in the form of a Merchandise Credit for the amount indicated on the gift receipt. Returns with original receipt will be refunded in the original form of payment, cash and check refunds over $100 will be issued as a company check (may take 14 business days from time of request).
For all cutlery returns (knife sets, single knives, cutting boards, knife sharpeners, and knife storage) please contact us at 888.922.4108 to initiate the return.
We cannot accept returns on monogrammed, personalized, special-order items, custom upholstery, food, items shipped direct from the vendor, or on items damaged through normal wear and tear. Final sale items ending in .97 or .99 cannot be returned.
For returns of items purchased from your Williams Sonoma Gift Registry, we will gladly provide a refund or exchange for the merchandise within 90 days of your event or within 90 days of purchase, whichever date is later. View Full Returns Policy.
- Price Match Guarantee
Williams Sonoma Price Match Guarantee
At Williams Sonoma, we're committed to bringing you the best quality at the best prices.
If you find a lower price on any of our products, we'll match it—guaranteed. Click here for details.


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How to Ruin a Perfectly Good Ballpark, in Six Easy Steps
Stop me if you've heard this one…
Step 1: Acquire a professional sports team that plays in an aging but hallowed and much-beloved stadium.
Step 2: Declare the team incapable of financial solvency if it doesn't receive a new stadium.
Step 3: Threaten to move the team out of town if it doesn't get everything it wants.
Step 4: Hire a top-dollar design firm to create a stadium plan that pays lip service to "tradition" and "history" but satisfies neither.
Step 5: Demand millions of dollars in public funding to build the new stadium.
Step 6: Overhaul—or raze—the old stadium, replacing it with something that is both an architectural monstrosity and a soulless fan experience.
Am I joking? Let's see…
Comiskey Park, built in 1910 for the Chicago White Sox. A classic of the early modern era albeit with its share of obstructed views. Itasca and Addison, Illinois are among the threatened move-to cities. The replacement, U.S. Cellular Field, is built at a cost of $167 million by the Illinois Sports Facilities Authority, a government agency. For supposedly historical reasons, the new stadium puts home plate nearest 35th Street—since that's where it was in Comiskey, which stood a block to the north. As a result, the view toward the outfield faces some of the city's most notorious housing projects (now razed and vacant lots) instead of the spectacular skyline to the north. A dozen follow-up renovations in as many years can never fix that.
Soldier Field, originally built as a memorial to fallen American servicemen following World War I, and home of the Chicago Bears since 1971. After a proposal for a domed replacement tanks, Hoffman Estates and Aurora are floated as options. The Chicago Park District, which owns the stadium, pays about 62% of a $660 million renovation. The resulting transformation retains the original colonnades but dwarfs them beneath an enormous and incongruous silver alien-spaceship-looking structure. Meanwhile inside, the stadium *loses* 5,000 seats, so that after a two-thirds-billion-dollar reno it is the smallest in the NFL.
Of course, there's always an exception to the rule… that being Chicago Stadium, home of the Blackhawks since its opening in 1929, and the Bulls since 1967. A grand old edifice and site of many historic events—but really not much more than a glorified barn. You know, the kind of place hockey is meant to be played in. Owners Reinsdorf (Bulls) and Wirtz (Blackhawks), neither one a saint, nevertheless do not (so far as I have found) threaten to pull out of town. They build the United Center without using public funds, getting only various tax breaks in return. I say "only" because the estimated $5 million per year in property tax savings seems a pittance compared to… say, Soldier Field's cost to the rest of us taxpayers. And the UC is not a bad arena, though it's much, much better for sports than it is for concerts.
So be prepared for the worst, Cubs fans. Because the Ricketts have already completed steps 1 through 5 like clockwork, as if they have read the Gimme a New Stadium Handbook cover to cover. Step 6 is inevitable. And as much as they want to pretend that their Wrigley Field overhaul will be sympathetic to the landmark structure, that it's a "restoration" to some supposed (but unprecedented) historic ideal, that it's all for our benefit, nothing about a massive Jumbotron is meant to improve the fan experience—it is purely for profit.
This for a team that is "incapable of financial solvency" (my words, but strongly implied by numerous public statements by the owners), despite having the highest operating income—and fourth highest revenue—in Major League Baseball.
The Trib's Cheryl Kent wrote a well-reasoned overview of the Wrigley Field plan from an architectural and urban-planning standpoint, revealing that despite including several good improvements it suffers from a severe lack of authenticity and a shortsightedness that runs counter to any claims by the owners of being "in it for the long run."


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Hey kids. Welcome to the new MOC Showcase forum. Instead of Star Wars MOCs being segregated from the rest of the Lego creations, everyone can now play in the same sandbox. Yay!
But we'd like to ask you to follow this simple rule to keep things organized and easy to read:
When starting a topic, please preface your topic name with a theme/license identifier.
What does that mean?
If you have a Star Wars model, say you build a new X-wing, yous topic title could read: [SW] Best X-WIng Evar!
Built a new castle? Your topic might be [CASTLE] Rocko's Fortress of Leiatude
Something spacey? [SPACE] Cap'n Booger's Stealth Snotter
If you're ever not sure what to call something, go with your gut instinct. If there's a problem with it, we'll take care of it! I've taken the opportunity with this first wave of posts in the forum to add my own suggested identifiers. If you don't like them, feel free to change them to something you feel is more appropriate.
Your cooperation in this matter would make the staff (and your fellow forum browsers) so happy.


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Oh so you have been bragging to all your friends have you? You have proclaimed yourself the pumpkin master and informed everyone that you can make pumpkin anything. Well your friends have decided to put you to the test by telling you to host a pumpkin dinner party. Each dish has to have pumpkin in it, in some way, shape or form. Now you are up a creek without a paddle, and you are afraid your boat will hit an iceberg along the way. Causing you to sink in front of all your friends. Having them all stare in awe and shock with their mouths' agape. Sure it is one thing to tell everyone you are a pumpkin genius, but it is a whole other league to actually be one. First of all, you need to find new friends. If they are inviting themselves to your house and ordering you to cook for them, and you are agreeing to do it all the time, well then you have bigger problems on your hand than a little pumpkin dinner. How would they like it if you invited yourself over their house and demanded they cook? Granted, you should not have been bragging in the first place. You have no one to blame but yourself.
So now the big day has come and you are freaking out. You have realized that perhaps you are not so savvy with that orange squash, as you thought or as you led them to believe. Sure you have dessert covered. Who does not know a thing or two about pumpkin desserts? That is a walk in the park. It is the easiest route to take. The easiest way to transform that gourd. Let us turn our attention to the main course, however. The biggest part of the dinner. You are worried that you cannot make a delicious savory dish with the star ingredient are you not? And you should be. You have every right to be nervous. I would be if I were in your shoes. I am not going to lie to you, it is very difficult to get people to like pumpkin in savory dishes because everyone goes into it with the misconception that it will taste like dessert. Stop crying and shaking your head! You have nothing to worry about. I am here to help you. Lucky for you I am a pumpkin master. Together we will get through this. Together we will conquer. Now buck up. Shoulders high. Raise that chin, proud like you know what you are doing. You have to have confidence. Put on your apron. Grab a spoon and a whisk. Cross your arms. Turn and look at your reflection on the oven. You are a master. Okay that is enough, you have a dinner party to throw. What are you doing just standing there looking like a fool with your arms crossed holding a whisk and spoon?!?! You need to start working! You are behind!
The best way to make people like anything, I have found, is to drench it in butter and cheese and cover it in a creamy sauce. Throw in some pasta and your are golden. Stop giving me that look of confusion. It is simple really. You are going to make Pumpkin Mac and Cheese. It has everything that most people enjoy. Tie it in with some autumn flavors and you are good to go. What do sage and thyme and pumpkin scream out to you? Yes that is right, Thanksgiving. It spells out Thanksgiving. So it does not really spell out Thanksgiving, but you get the point. You are going to wow your friends with this dish.
You have put together the sauce—which is now a beautiful light orange color thanks to the pumpkin—and are now mixing in the pasta. Stop eating it. This is for your pushy self-inviting friends. Throw the mac and cheese into the ramekins, hurry. Sprinkle on the sage breadcrumbs. Stand back. Look at that. Admire the pumpkin mac and cheese. Does it not look delicious like I had promised? Does it not smell fantastic? Okay, what are you doing? Enough standing around. Pop the tray in the oven. These have to bake. Your friends are due at any minute! Look at yourself! You are a mess! There is flour on your face. Cheese sauce in your hair. Pull yourself together! You cannot let your friends see you like this! Go change! The door bell rings at the same time that the oven timer goes off. Just in time. Your soon-to-be-ex-friends are finally here and they enter with a look as if they know they have won. Little do they know you had an ace up your sleeve. Let the party begin.


text: This is a story called Bengaluru Beer. There is a fear that Delhi might over Bangalore as the Pub City of India– or has it already? The one person who I wanted to interview for this piece but couldn't do it by deadline was a man from a company called Ambicon. They make equipment for brewing beer, which to me, is a sign that craft beer in India has come of age.


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The graft-versus-leukemia (GVL) effect in allogeneic hematopoietic stem cell transplantation (alloSCT) is potent against chronic phase chronic myelogenous leukemia (CP-CML), but blast crisis CML (BC-CML) and acute myeloid leukemias (AML) are GVL resistant. To understand GVL resistance, we studied GVL against mouse models of CP-CML, BC-CML, and AML generated by the transduction of mouse BM with fusion cDNAs derived from human leukemias. Prior work has shown that CD4+ T cell–mediated GVL against CP-CML and BC-CML required intact leukemia MHCII; however, stem cells from both leukemias were MHCII negative. Here, we show that CP-CML, BC-CML, and AML stem cells upregulate MHCII in alloSCT recipients. Using gene-deficient leukemias, we determined that BC-CML and AML MHC upregulation required IFN-γ stimulation, whereas CP-CML MHC upregulation was independent of both the IFN-γ receptor (IFN-γR) and the IFN-γ/γ receptor IFNAR1. Importantly, IFN-γR–deficient BC-CML and AML were completely resistant to CD4- and CD8-mediated GVL, whereas IFN-γR/IFNAR1 double-deficient CP-CML was fully GVL sensitive. Mouse AML and BC-CML stem cells were MHCI+ without IFN-γ stimulation, suggesting that IFN-γ sensitizes these leukemias to T cell killing by mechanisms other than MHC upregulation. Our studies identify the requirement of IFN-γ stimulation as a mechanism for BC-CML and AML GVL resistance, whereas independence from IFN-γ renders CP-CML more GVL sensitive, even with a lower-level alloimmune response.
Catherine Matte-Martone, Jinling Liu, Meng Zhou, Maria Chikina, Douglas R. Green, John T. Harty, Warren D. Shlomchik
Generation of functional hematopoietic stem and progenitor cells (HSPCs) from human pluripotent stem cells (PSCs) has been a long-sought-after goal for use in hematopoietic cell production, disease modeling, and eventually transplantation medicine. Homing of HSPCs from bloodstream to bone marrow (BM) is an important aspect of HSPC biology that has remained unaddressed in efforts to derive functional HSPCs from human PSCs. We have therefore examined the BM homing properties of human induced pluripotent stem cell–derived HSPCs (hiPS-HSPCs). We found that they express molecular effectors of BM extravasation, such as the chemokine receptor CXCR4 and the integrin dimer VLA-4, but lack expression of E-selectin ligands that program HSPC trafficking to BM. To overcome this deficiency, we expressed human fucosyltransferase 6 using modified mRNA. Expression of fucosyltransferase 6 resulted in marked increases in levels of cell surface E-selectin ligands. The glycoengineered cells exhibited enhanced tethering and rolling interactions on E-selectin–bearing endothelium under flow conditions in vitro as well as increased BM trafficking and extravasation when transplanted into mice. However, glycoengineered hiPS-HSPCs did not engraft long-term, indicating that additional functional deficiencies exist in these cells. Our results suggest that strategies toward increasing E-selectin ligand expression could be applicable as part of a multifaceted approach to optimize the production of HSPCs from human PSCs.
Jungmin Lee, Brad Dykstra, Joel A. Spencer, Laurie L. Kenney, Dale L. Greiner, Leonard D. Shultz, Michael A. Brehm, Charles P. Lin, Robert Sackstein, Derrick J. Rossi
Programmed death ligand-1 (PD-L1) interacts with programmed death-1 (PD-1) and the immunostimulatory molecule CD80 and functions as a checkpoint to regulate immune responses. The interaction of PD-L1 with CD80 alone has been shown to exacerbate the severity of graft-versus-host disease (GVHD), whereas costimulation of CD80 and PD-1 ameliorates GVHD. Here we have demonstrated that temporary depletion of donor CD4+ T cells early after hematopoietic cell transplantation effectively prevents GVHD while preserving strong graft-versus-leukemia (GVL) effects in allogeneic and xenogeneic murine GVHD models. Depletion of donor CD4+ T cells increased serum IFN-γ but reduced IL-2 concentrations, leading to upregulation of PD-L1 expression by recipient tissues and donor CD8+ T cells. In GVHD target tissues, the interactions of PD-L1 with PD-1 on donor CD8+ T cells cause anergy, exhaustion, and apoptosis, thereby preventing GVHD. In lymphoid tissues, the interactions of PD-L1 with CD80 augment CD8+ T cell expansion without increasing anergy, exhaustion, or apoptosis, resulting in strong GVL effects. These results indicate that the outcome of PD-L1–mediated signaling in CD8+ T cells depends on the presence or absence of CD4+ T cells, the nature of the interacting receptor expressed by CD8+ T cells, and the tissue environment in which the signaling occurs.
Xiong Ni, Qingxiao Song, Kaniel Cassady, Ruishu Deng, Hua Jin, Mingfeng Zhang, Haidong Dong, Stephen Forman, Paul J. Martin, Yuan-Zhong Chen, Jianmin Wang, Defu Zeng
Acute graft-versus-host disease (aGVHD) is the most common complication for patients undergoing allogeneic stem cell transplantation. Despite extremely aggressive therapy targeting donor T cells, patients with grade III or greater aGVHD of the lower GI tract, who do not respond to therapy with corticosteroids, have a dismal prognosis. Thus, efforts to improve understanding of the function of local immune and non-immune cells in regulating the inflammatory process in the GI tract during aGVHD are needed. Here, we demonstrate, using murine models of allogeneic BMT, that type 2 innate lymphoid cells (ILC2s) in the lower GI tract are sensitive to conditioning therapy and show very limited ability to repopulate from donor bone marrow. Infusion of donor ILC2s was effective in reducing the lethality of aGVHD and in treating lower GI tract disease. ILC2 infusion was associated with reduced donor proinflammatory Th1 and Th17 cells, accumulation of donor myeloid-derived suppressor cells (MDSCs) mediated by ILC2 production of IL-13, improved GI tract barrier function, and a preserved graft-versus-leukemia (GVL) response. Collectively, these findings suggest that infusion of donor ILC2s to restore gastrointestinal tract homeostasis may improve treatment of severe lower GI tract aGVHD.
Danny W. Bruce, Heather E. Stefanski, Benjamin G. Vincent, Trisha A. Dant, Shannon Reisdorf, Hemamalini Bommiasamy, David A. Serody, Justin E. Wilson, Karen P. McKinnon, Warren D. Shlomchik, Paul M. Armistead, Jenny P.Y. Ting, John T. Woosley, Bruce R. Blazar, Dietmar M.W. Zaiss, Andrew N.J. McKenzie, James M. Coghill, Jonathan S. Serody
Kit L. Shaw, Elizabeth Garabedian, Suparna Mishra, Provaboti Barman, Alejandra Davila, Denise Carbonaro, Sally Shupien, Christopher Silvin, Sabine Geiger, Barbara Nowicki, E. Monika Smogorzewska, Berkley Brown, Xiaoyan Wang, Satiro de Oliveira, Yeong Choi, Alan Ikeda, Dayna Terrazas, Pei-Yu Fu, Allen Yu, Beatriz Campo Fernandez, Aaron R. Cooper, Barbara Engel, Greg Podsakoff, Arumugam Balamurugan, Stacie Anderson, Linda Muul, G. Jayashree Jagadeesh, Neena Kapoor, John Tse, Theodore B. Moore, Ken Purdy, Radha Rishi, Kathey Mohan, Suzanne Skoda-Smith, David Buchbinder, Roshini S. Abraham, Andrew Scharenberg, Otto O. Yang, Kenneth Cornetta, David Gjertson, Michael Hershfield, Rob Sokolic, Fabio Candotti, Donald B. Kohn
In transplantation, there is a critical need for noninvasive biomarker platforms for monitoring immunologic rejection. We hypothesized that transplanted tissues release donor-specific exosomes into recipient circulation and that the quantitation and profiling of donor intra-exosomal cargoes may constitute a biomarker platform for monitoring rejection. Here, we have tested this hypothesis in a human-into-mouse xenogeneic islet transplant model and validated the concept in clinical settings of islet and renal transplantation. In the xenogeneic model, we quantified islet transplant exosomes in recipient blood over long-term follow-up using anti-HLA antibody, which was detectable only in xenoislet recipients of human islets. Transplant islet exosomes were purified using anti-HLA antibody–conjugated beads, and their cargoes contained the islet endocrine hormone markers insulin, glucagon, and somatostatin. Rejection led to a marked decrease in transplant islet exosome signal along with distinct changes in exosomal microRNA and proteomic profiles prior to appearance of hyperglycemia. In the clinical settings of islet and renal transplantation, donor exosomes with respective tissue specificity for islet β cells and renal epithelial cells were reliably characterized in recipient plasma over follow-up periods of up to 5 years. Collectively, these findings demonstrate the biomarker potential of transplant exosome characterization for providing a noninvasive window into the conditional state of transplant tissue.
Prashanth Vallabhajosyula, Laxminarayana Korutla, Andreas Habertheuer, Ming Yu, Susan Rostami, Chao-Xing Yuan, Sanjana Reddy, Chengyang Liu, Varun Korutla, Brigitte Koeberlein, Jennifer Trofe-Clark, Michael R. Rickels, Ali Naji
Tissue fibrosis is the primary cause of long-term graft failure after organ transplantation. In lung allografts, progressive terminal airway fibrosis leads to an irreversible decline in lung function termed bronchiolitis obliterans syndrome (BOS). Here, we have identified an autocrine pathway linking nuclear factor of activated T cells 2 (NFAT1), autotaxin (ATX), lysophosphatidic acid (LPA), and β-catenin that contributes to progression of fibrosis in lung allografts. Mesenchymal cells (MCs) derived from fibrotic lung allografts (BOS MCs) demonstrated constitutive nuclear β-catenin expression that was dependent on autocrine ATX secretion and LPA signaling. We found that
Pengxiu Cao, Yoshiro Aoki, Linda Badri, Natalie M. Walker, Casey M. Manning, Amir Lagstein, Eric R. Fearon, Vibha N. Lama
Patients with leukemia who receive a T cell–depleted allogeneic stem cell graft followed by postponed donor lymphocyte infusion (DLI) can experience graft-versus-leukemia (GVL) reactivity, with a lower risk of graft-versus-host disease (GVHD). Here, we have investigated the magnitude, diversity, and specificity of alloreactive CD8 T cells in patients who developed GVL reactivity after DLI in the absence or presence of GVHD. We observed a lower magnitude and diversity of CD8 T cells for minor histocompatibility antigens (MiHAs) in patients with selective GVL reactivity without GVHD. Furthermore, we demonstrated that MiHA-specific T cell clones from patients with selective GVL reactivity showed lower reactivity against nonhematopoietic cells, even when pretreated with inflammatory cytokines. Expression analysis of MiHA-encoding genes showed that similar types of antigens were recognized in both patient groups, but in patients who developed GVHD, T cell reactivity was skewed to target broadly expressed MiHAs. As an inflammatory environment can render nonhematopoietic cells susceptible to T cell recognition, prevention of such circumstances favors induction of selective GVL reactivity without development of GVHD.
Cornelis A.M. van Bergen, Simone A.P. van Luxemburg-Heijs, Liesbeth C. de Wreede, Matthijs Eefting, Peter A. von dem Borne, Peter van Balen, Mirjam H.M. Heemskerk, Arend Mulder, Fransiscus H.J. Claas, Marcelo A Navarrete, Wilhelmina M. Honders, Caroline E. Rutten, Hendrik Veelken, Inge Jedema, Constantijn J.M. Halkes, Marieke Griffioen, J.H. Frederik Falkenburg
Damage to the gastrointestinal tract is a major cause of morbidity and mortality in graft-versus-host disease (GVHD) and is attributable to T cell–mediated inflammation. In this work, we identified a unique CD4+ T cell population that constitutively expresses the β2 integrin CD11c and displays a biased central memory phenotype and memory T cell transcriptional profile, innate-like properties, and increased expression of the gut-homing molecules α4β7 and CCR9. Using several complementary murine GVHD models, we determined that adoptive transfer and early accumulation of β2 integrin–expressing CD4+ T cells in the gastrointestinal tract initiated Th1-mediated proinflammatory cytokine production, augmented pathological damage in the colon, and increased mortality. The pathogenic effect of this CD4+ T cell population critically depended on coexpression of the IL-23 receptor, which was required for maximal inflammatory effects. Non–Foxp3-expressing CD4+ T cells produced IL-10, which regulated colonic inflammation and attenuated lethality in the absence of functional CD4+Foxp3+ T cells. Thus, the coordinate expression of CD11c and the IL-23 receptor defines an IL-10–regulated, colitogenic memory CD4+ T cell subset that is poised to initiate inflammation when there is loss of tolerance and breakdown of mucosal barriers.
Vivian Zhou, Kimberle Agle, Xiao Chen, Amy Beres, Richard Komorowski, Ludovic Belle, Carolyn Taylor, Fenlu Zhu, Dipica Haribhai, Calvin B. Williams, James Verbsky, Wendy Blumenschein, Svetlana Sadekova, Eddie Bowman, Christie Ballantyne, Casey Weaver, David A. Serody, Benjamin Vincent, Jonathan Serody, Daniel J. Cua, William R. Drobyski
The immune response against transplanted allografts is one of the most potent reactions mounted by the immune system. The acute rejection response has been attributed to donor dendritic cells (DCs), which migrate to recipient lymphoid tissues and directly activate alloreactive T cells against donor MHC molecules. Here, using a murine heart transplant model, we determined that only a small number of donor DCs reach lymphoid tissues and investigated how this limited population of donor DCs efficiently initiates the alloreactive T cell response that causes acute rejection. In our mouse model, efficient passage of donor MHC molecules to recipient conventional DCs (cDCs) was dependent on the transfer of extracellular vesicles (EVs) from donor DCs that migrated from the graft to lymphoid tissues. These EVs shared characteristics with exosomes and were internalized or remained attached to the recipient cDCs. Recipient cDCs that acquired exosomes became activated and triggered full activation of alloreactive T cells. Depletion of recipient cDCs after cardiac transplantation drastically decreased presentation of donor MHC molecules to directly alloreactive T cells and delayed graft rejection in mice. These findings support a key role for transfer of donor EVs in the generation of allograft-targeting immune responses and suggest that interrupting this process has potential to dampen the immune response to allografts.
Quan Liu, Darling M. Rojas-Canales, Sherrie J. Divito, William J. Shufesky, Donna Beer Stolz, Geza Erdos, Mara L.G. Sullivan, Gregory A. Gibson, Simon C. Watkins, Adriana T. Larregina, Adrian E. Morelli
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"The customer is always right." That is the long-honored "golden rule" for success in the hospitality industry—an industry made of many sectors whose importance to the United States and world economies must not be under estimated. The travel and tourism industry in the U.S. supports more than 8 million jobs and makes up 2.7 percent of U.S. gross domestic product. The golden rule reflects the spirit with which successful casinos, spas, and other hospitality industry businesses regard and treat their patrons and clients—with an understanding of, and responsiveness to, their unique needs and concerns.
Epstein Becker Green (EBG) has also mastered the golden rule. We approach each matter with a single goal: to obtain a thorough understanding of the issue, and then respond promptly, effectively, and efficiently to resolve it to the client's satisfaction.
Our Services
EBG has been advising and representing clients in the hospitality industry with their business needs for more than 40 years. Attorneys in all practices and offices of the firm handle a broad range of matters for our hospitality clients. For instance, hospitality clients rely on us for the following:
Health Care Services
We counsel our clients on the health care and health benefit issues and laws that they must comply with, including requirements under the Affordable Care Act.
Employment, Labor, and Workforce Management Services
EBG has long been a leader in providing labor and employment legal services to the hospitality industry. The Hospitality service team at EBG handles every aspect of labor and employment law affecting the industry.
The very nature of the hospitality industry presents unique labor and employment issues. Few other industries open their doors and invite the public to interact with their employees. That fact alone not only makes these businesses susceptible to union organizing and large scale litigation, including wage-hour class actions and collective actions, but presents unusual challenges in handling those matters.
EBG's hospitality industry clients have the benefit of attorneys who recognize and know how to address these challenges—and, just as importantly, understand their businesses. That experience is invaluable in assisting hospitality industry employers in dealing with:
- Collective bargaining
- Contracts and employee handbooks
- Discrimination complaints
- Employee benefits
- ERISA compliance
- Immigration and worksite enforcement
- Internal audits
- Union avoidance
- Wage-hour issues
Litigation Support
EBG offers a wide range of dispute avoidance and litigation services to help clients in the hospitality industry meet the challenges of compliance and litigation in both civil and criminal cases. When litigation or business disputes arise, our clients rely on our team of highly skilled litigators to fervently advocate their interests. Our litigators have extensive experience resolving disputes in federal and state trial and appellate courts and arbitral forums and through mediation.
Our Clients
EBG advises and represents a wide variety of hospitality clients, including:
- Gaming and casino operations
- Golf courses, sports clubs, and spas
- Hotels and resorts
- Lenders, investors, and developers involved in the financing and building of hospitality industry facilities
- Long-term residential health care and nursing facility management, including nursing homes, long-term rehabilitation centers, and assisted living facilities
- Private catering services and large institutional food service providers
- Restaurant owners and operators
- Support services and supply companies, including laundry, maintenance, and office support services and hotel and restaurant suppliers
- Travel and tourism owners and operators, including travel agents, tour operators, and tourist transportation companies (e.g., airlines, cruise lines, tour buses)
- Universities and private schools where students live on campus
Representative Matters
- Collective Bargaining: We negotiated collective bargaining agreements covering various bargaining units for hotels throughout the United States, which included implementing "economic distress" clauses, "operation efficiency" provisions, and the elimination of past practice restrictions.
- Employee Benefits: We implemented the consolidation of retirement plans for a hotel management company, advised on significant means to reduce multi-employer withdrawal liability, and restructured a medical plan to save future costs and comply with new health care requirements.
- Employment Discrimination: We successfully obtained summary judgment on behalf of a hotel management company that faced pregnancy and gender discrimination liability under a maternity leave act. The case raised novel questions of the maternity law's applicability to females who give birth to multiple infants.
- Health Care: We provide ongoing advice and counsel to hospitality clients throughout the United States regarding compliance with health care laws.
- Transition Issues: We advised an international hotel company on labor and employment issues related to opening hotels in the United States. And we developed a strategy on all aspects of the opening, which included applications, interviewing, hiring, employee policies, management training, and Americans with Disabilities Act compliance audits.
- Wage and Hour: We defeated class certifications in wage and hour cases concerning the misclassifications of "exempt" employees, the treatment of service charges, tip pooling, overtime calculations, and other payment issues.


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In 1971 Grease was still a Broadway musical. Seven years later it became a movie. It was released in American movie theaters for the first time in 1978, with the legendary John Travolta as Danny and young Olivia Newton-John as Sandy. The film can really be seen as the kick-off of Travolta and Newton-John's actor careers, as they soon became national and international movie icons. In 1998, a 20 year anniversary edition was released in order to celebrate this piece of cinematography. This past Christmas, Travolta and Newton-John reunited for a special Soundtrack Christmas edition, on which they perform among others classics such as the famous 'Summer Nights'.
Read Vincent Candby's excited review on Grease that he published in 1978 in the New York Times, and then grab your blankets and hurry to Bryant Park next Monday, to view the movie at the final evening of the Citi Pond Winter Film Festival.
Grease (1978)
Screen: A Slick Version of 'Grease': Fantasy of the 50's
By VINCENT CANBY
The New York Times
Published: June 16, 1978
"GREASE," the film version of the still-running Broadway musical show, is not really the 1950's teen-age movie musical it thinks it is, but a contemporary fantasy about a 1950's teen-age musical—a larger, funnier, wittier and more imaginative-than-Hollywood movie with a life that is all its own. It uses the Eisenhower era — the characters, costumes, gestures and particularly, the music—to create a time and place that have less to do with any real 50's than with a kind of show business that is both timeless and old-fashioned, both sentimental and wise. The movie, which opens today at Loews State 2 and other theaters, is also terrific fun.
Because I seem to be one of the few persons who has never seen the Broadway show, I'm not sure how the movie differs from the original, yet it's apparent that the film's score, which is one of the best things about the production, has been liberally supplemented by new material and new-old material, including "Love Is a Many Splendored Thing," which has never before sounded so marvelously, soaringly inane.
Somewhat in the manner of "Close Encounters of the Third Kind," which recalls the science-fiction films of the 50's in a manner more elegant and more benign, than anything that was ever made then, "Grease" is a multimillion-dollar evocation of the B-picture quickies that Sam Katzman used to turn out in the 50's ("Don't Knock the Rock," 1957) and that American International carried to the sea in the 1960's ("Beach Party," 1963).
The gang at old Rydell High, which is the universe of "Grease," is unlike any high school class you've ever seen except in the movies. For one thing, they're all rather long in the tooth to be playing kids who'd hang around malt shops. For another, they are loaded with the kind of talent and exuberance you don't often find very far from a musical stage. They not only portray characters but effectively make comments on them.
Olivia Newton-John, the recording star in her American film debut, is simultaneously very funny and utterly charming as the film's ingénue, a demure, virginal Sandra Dee-type. She possesses true screen presence as well as a sweet, sure singing voice, while the Sandra Dee I remember had a voice that seemed to have been manufactured in Universal's speech-and-special-effects department.
John Travolta, as Miss Newton-John's costar, a not-so-malevolent gang-leader, is better than he was in "Saturday Night Fever." I'm still not sure if he's a great actor, but he's a fine performer with the kind of energy and humor that are brought to life by the musical numbers.
Stockard Channing, as the high school's tramp who has a dirty mouth and a heart of gold, would (if it were possible) stop the show twice, once with a pasty put-on of poor Olivia ("Look at Me, I'm Sandra Dee") and another when she attempts, in song, to explain why it's more honorable to be loose than uptight ("There Are Worse Things I Could Do").
The film's producers, Robert Stigwood and Allen Carr, and director, Rundel Kleiser (whose first theatrical feature this is), have also supplemented the cast of comparative youngsters with a whole crowd of actors we associate with the 50's, and who seem here to have survived with barely a visible dent.
Eve Arden, a fixture of the 50's as Our Miss Brooks, plays Rydell High's unflappable principal; Sid Caesar is the football coach; Edd Byrnes comes on briefly as the lecherous host of a teen-age TV show that decides to spotlight Rydell in a network program; Jean Blondell is the harassed waitress at the corner soda fountain, and, maybe funniest of all, is Frankie Avalon, who appears in a dream sequence to counsel an unhappy student ("Beauty School Dropout").
Bronte Woodward has adapted the Broadway book by Jim Jacobs and Warren Casey, who also wrote the show's original score, in such a way that the plot serves the purpose of the music without needlessly interfering with it.
It's to the director's credit that the musical numbers slip in and out of reality mostly with hugely comic effect. The highlights of the stage show include the upbeat rock number, "We Go Together," and the rueful "Summer Nights," both sung by Mr. Travolta and Miss Newton-John, but the hit of the film is probably a breathless new number, "You're the One That, I Want," written by John Farrar and beautifully choreographed by Patricia Birch.
Because there haven't been that many movie musicals recently, it doesn't mean much to say that "Grease" is the best we've had in years. I'm also afraid that people who (like me) have no special fondness for the 50's might be put off by the film's time and place. Let me emphasize, then, that "Grease" stands outside the traditions it mimics. Its sensibility is not tied to the past but to a free-wheeling, well informed, high-spirited present.
"Grease," which has been ruled PG ("Parental Guidance Suggested") has some language that would never have been heard even on Broadway in the 50's, and though it deals with teen-age lust quite frankly, it's heart is always pure.
Fantasy of the 50's
GREASE, directed by Randal Kleiser; screenplay Bronte Woodward, adapted by Allan Carr from the Broadway musical by Jim Jacobs and Warren Casey; produced by Robert Stigwood and Mr. Carr; dances and musical sequences staged and choreographed by Patricia Birch; music supervision Bill Oakes; director of photography, Bill Butler; editor, John F. Burnett; distributed by Paramount Pictures. Running time: 110 minutes. At Loews State 2, Broadway at 45th Street, and other theaters. This film has been rated PG.
Danny . . . . . John Travolta
Sandy . . . . . Olivia Newton-John
Rizzo . . . . . Stockard Channing
Kenickie . . . . . Jeff Conway
Frenchy . . . . . Didi Conn
Principal McGee . . . . . Eve Arden
Teen Angel . . . . . Frankie Avalon
Vi . . . . . Joan Blondell
Vince Fontaine . . . . . Edd Byrnes
Coach Calhoua . . . . . Sid Caesar
Mrs. Murdock . . . . . Alice Ghostley
Blanche . . . . . Dody Goodman
Johnny Casino and the Gamblers . . . . . Sha-Na-Na
Jan . . . . . Jamie Donnelly
Marty . . . . . Dinah Manoff
Doody . . . . . Barry Pearl
Sonny . . . . . Michael Tucci
Putzie . . . . . Kelly Ward
Patty Simcox . . . . . Susan Buckner
Eugene . . . . . Eddie Deszen
Tom Chisum . . . . . Lorenzo Lamas
Leo . . . . . Dennis C. Stewart
Cha Cha . . . . . Annette Charles
Mr. Rudie . . . . . Dick Patterson
Nurse Wilkins . . . . . Fannie Flagg
Mr. Lynch . . . . . Darrell Zwerling
Waitress . . . . . Ellen Travolta


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Assessment of Variation in the Alberta Context Tool: The Contribution of Unit Level Contextual Factors and Specialty in Canadian Pediatric Acute Care SettingsDownload
Stevens, B., Squires, J.E., Hutchinson, A., Midodzi, W.K., Cummings, G.G., Kang, S.H., Scott, S., Estabrooks, C.A.
Background: There are few validated measures of organizational context and none that we located are parsimonious and address modifiable characteristics of context. The Alberta Context Tool (ACT) was developed to meet this need. The instrument assesses 8 dimensions of context, which comprise 10...
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