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LEGO artisan Tsang Yiu Keung has discovered the secret to success in Rovio's ridiculously popular Angry Birds: If throwing birds doesn't stop the pigs, throw bricks instead.
LEGO bricks, to be precise. Tsang has painstakingly recreated most of the game's major players in LEGO form, right down to a little LEGO slingshot for hurling blocky avians long distances.
My LEGO expertise is currently limited to pre-packaged sets. This gallery makes me want to try venturing out on my own, or begging Tsang for instructions.
LEGO Angry Birds - created by Chiukeung [Facebook - Thanks RadicalDreamer!]


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Academic round-up
A recent New York Times editorial accused the D.C. Circuit of flouting the Supreme Court's decision in Boumediene v. Bush by barring habeas relief for Guantanamo Bay detainees. Legal scholars are now weighing in on that controversial issue.
In Boumediene, the Court held that detainees are constitutionally entitled to pursue habeas relief in federal courts, but it gave almost no guidance regarding the procedural, evidentiary, and substantive rules that should govern that process. The burden of developing those rules has fallen squarely on the federal courts in Washington, D.C., which are the sole forum for these claims. The D.C. Circuit's post-Boumediene jurisprudence has its critics, as well as its defenders. By far the most controversial critique is that the lower court is actively subverting the Supreme Court's Boumediene decision by creating needless obstacles to habeas relief.
Professor Stephen Vladeck, a colleague at American University who has devoted his career to studying this litigation, has delved into the debate in an essay to be published in the Seton Hall Law Review. The essay engages in a close analysis of the D.C. Circuit's post-Boumediene case law to determine whether that court merits the criticism it has received from some quarters. Although Vladeck disagrees with the claim that D.C. Circuit judges are engaged in a collective effort to defy the Supreme Court, he concludes that some jurists on that court have demonstrated "hostility to the Supreme Court's jurisprudence."
Benjamin Wittes, Robert Chesney, and Larkin Reynolds shed further light on these questions in their recent Brookings publication entitled The Emerging Law of Detention: The Guantanamo Habeas Cases as Lawmaking 2.0. They point out that whatever one thinks of the D.C. Circuit's approach, we would be better off if legislators, rather than judges, set U.S. habeas policy.
Both of these publications are a terrific resource for the reader who wants to understand how Boumediene is being applied in dozens of habeas cases making their way through the lower courts.
Recommended Citation: Amanda Frost, Academic round-up, SCOTUSblog (May. 18, 2011, 1:58 PM), https://www.scotusblog.com/2011/05/academic-round-up-70/

subset: commoncrawl


text: Whole New Design to Fully Unleash AM3 CPU Potential O.C. DDR2 1300 8+1 Phase Power Design EPU TurboV Turbo Key ASUS Anti-Surge Protection AMD 140W CPU Support Support 45nm Phenom™ II CPU Shop Modal header CPU, Chipset and Graphics Features AMD® Phenom™ II/Athlon™ II/Sempron™ 100 Series Processors(AM3 CPU) This motherboard supports AMD® AM3 multi-core processors with unique L3 cache and delivers better overclocking capabilities with less power consumption. It features dual-channel DDR2 1066 memory support and accelerates data transfer rate up to 5200MT/s via HyperTransport™ 3.0 based system bus. This motherboard also supports AMD® CPUs in the new 45nm manufacturing process. NVIDIA nForce® 750a SLI™ NVIDIA nForce® 750a SLI™ media and communications processors (MCPs) are the foundation for the world's ultimate gaming PC. Experience spectacular DirectX® 10 gaming with the best platform for GeForce Graphic Processing Units (GPUs). PCIe 2.0 support This motherboard supports the latest PCIe 2.0 devices for double speed and bandwidth which enhances system performance. AMD® Phenom™ X4/ Phenom™ X3/ Athlon™ X2/ Athlon™/ Sempron™ processors (socket AM2+/AM2) This motherboard supports AMD® Socket AM2+ multi-core processors. It features dual-channel DDR2 1066 memory support, data transfer rate up to 5200MT/s via HyperTransport™ 3.0 based system bus, and AMD® Cool ´n´ QuietTM Technology. O.C. DDR2 1300 To attain top performance, ASUS engineers have successfully unleashed DDR2 1300(O.C.) MHz to meet the higher bandwidth requirements of the latest operation system, 3D graphics, multimedia, and Internet applications. *Ensure that you download and update to the latest BIOS at www.asus.com and purchase the memory modules listed in the ASUS official memory Qualified Vendors Lists (QVL).** We recommend that you install the DDR2 1300 memory modules on the yellow slots for better performance.*** It is recommended that you install an optional fan facing the DIMM module for better cooling performance when using DDR2 1300. ASUS Power Solutions 8+1 Phase Power Design To fully unleash the next-generation AM3 CPU´s potential, the ASUS M4 Series motherboards have adopted a brand new 8-phase VRM power design. It delivers high power efficiency and supreme overclocking ability. Furthermore, high quality power components can effectively lower system temperature to ensure longer component lifespan. This series also features an extra 2 (or 1) phase power dedicated to integrated memory/HT controller. ASUS Anti-Surge Protection This special design prevents expensive devices and the motherboard from damage caused by power surges. ASUS Green Design EPU The ASUS EPU (Energy Processing Unit) provides total system power management by detecting current PC loadings and intelligently moderating power in real-time. It automatically provides the most appropriate power usage for the CPU, VGA card, hard drives, and CPU/chassis fans- helping save power and money! AI Nap With AI Nap, the system can continue running at minimum power and noise when you are temporarily away. To wake the system and return to the OS environment, simply click the mouse or press a key. ASUS Overclocking Tools TurboV Feel the adrenaline rush of real-time O.C. - now a reality with the ASUS TurboV. This easy O.C. tool allows you to overclock without exiting or rebooting the OS; and its user-friendly interface makes overclock with just a few clicks away. Moreover, the ASUS OC profiles in TurboV provides the best O.C. settings in different scenarios. Turbo Key ASUS Turbo Key allows the user to turn the PC power button into an overclocking button. After the easy setup, Turbo Key can boost performances without interrupting ongoing work or games - with just one touch!! Express Gate Express Gate 0 to Internet in Seconds!Express Gate™ is an ASUS exclusive OS that provides you with quick access to the Internet and key applications before entering Windows®. ASUS EZ DIY Q-Connector ASUS Q-Connector allows you to easily connect or disconnect the chassis front panel cables to the motherboard. This unique module eliminates the trouble of connecting the system panel cables one at a time and avoiding wrong cable connections EZ Flash 2 EZ Flash 2 is a user-friendly BIOS update utility. Simply launch this tool and update BIOS from a USB flash disk before entering the OS. You can update your BIOS only in a few clicks without preparing an additional floppy diskette or using an OS-based flash utility. O.C. Profile The motherboard features the ASUS O.C. Profile that allows users to conveniently store or load multiple BIOS settings. The BIOS settings can be stored in the CMOS or a separate file, giving users freedom to share and distribute their favorite overclocking settings. Q-Shield Make Connection Quick and Accurate!The ASUS Q-Connector allows you to connect or disconnect chassis front panel cables in one easy step with one complete module. This unique adapter eliminates the trouble of plugging in one cable at a time, making connection quick and accurate. CrashFree BIOS 2 This feature allows you to restore the original BIOS data from the support CD in case when the BIOS codes and the data are corrupted. This protection eliminates the need to buy a replacement ROM chip. ASUS Quiet Thermal Solutions ASUS Q-Fan 2 ASUS Q-Fan2 technology intelligently adjusts both CPU fan and chassis fan speeds according to system loading to ensure quiet, cool and efficient operation. Special Thermal Design The streamline-shaped heatsink features 0-dB thermal solution that offers users a noiseless PC environment. Not only the beautifully curved fins upgrade the visual enjoyment for motherboard users, but also the special Streamline Airflow Guiding design lowers the temperature of the north bridge chipset through high efficient heat-exchange. Combined with usability and aesthetics, the ASUS streamline-shaped heat-sink will give users an extremely silent and cooling experience with the elegant appearance! Other ASUS Features 100% All High-quality Conductive Polymer Capacitors This motherboard uses all high-quality conductive polymer capacitors onboard for durability, improved lifespan, and enhanced thermal capacity. MyLogo2 Personalize your system with customizable boot logoYou can convert your favorite photo into a 256-color boot logo for a more colorful and vivid image on your screen. ASUS Crystal Sound Noise Filtering Eliminate background noise while recordingThis feature detects repetitive and stationary noises like computer fans, air conditioners, and other background noises then eliminates it in the incoming audio stream while recording. DTS Surround Sensation UltraPC DTS Surround Sensation UltraPC delivers exceptional 5.1 surround experience through the most common PC audio setups - your existing stereo speakers or headphones. In addition to virtual surround, "Bass enhancement" provides stronger low frequency bass sound, and "Voice clarification" provides clear human dialogue even with loud background sound. With these technologies, you may experience a better home-theater audio with ease.To experience DTS Surround Sensation UltraPC, download the updated audio driver & latest BIOS at www.asus.com. Industry Standard IEEE 1394a interface IEEE 1394a interface provides high speed digital interface for audio/video appliances such as digital television, digital video camcorders, storage peripherals & other PC portable devices. High Definition Audio Enjoy high-end sound system on your PC!The onboard 8-channel HD audio (High Definition Audio, previously codenamed Azalia) CODEC enables high-quality 192KHz/24-bit audio output, jack-sensing feature, retasking functions and multi-streaming technology that simultaneously sends different audio streams to different destinations. You can now talk to your partners on the headphone while playing a multi-channel network games. All of these are done on one computer. S/PDIF-out on Back I/O Port This motherboard provides convenient connectivity to external home theater audio systems via coaxial and optical S/PDIF-out (SONY-PHILIPS Digital Interface) jacks. It allows to transfer digital audio without converting to analog format and keeps the best signal quality. RoHS GreenASUS The motherboard and its packaging comply with the European Union´s Restriction on the use of Hazardous Substances (RoHS). This is in line with the ASUS vision of creating environment-friendly and recyclable products and packaging to safeguard consumers´ health while minimizing the impact on the environment.


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Coldingley Prison information
Coldingley was opened in 1969 as a Category B training prison. In 1993 it was re-designated as Category C training prison.
Coldingley is focused on the resettlement of prisoners. It provides a framework to support the achievement of realistic resettlement goals by offering opportunities to prisoners willing to work hard and accept responsibility for achieving those goals.
Shaftesbury Road
Tel: 01483 344300
Fax: 01483 344427
Governor: Jo Sims
Accommodation: Majority single cells, with a small number of double cells.
Operational Capacity: 513 as of 18th May 2009
Accommodation: Majority single cells, with a small number of double cells. Five wings, four with electronic unlocking night sanitation and one, newly built, with integral sanitation. In-cell TV available on all wings for standard and enhanced prisoners. PINphones on all wings.
Reception Criteria: Normal reception arrangements, all sentence lengths including life sentence prisoners.
Prisoners must:
- be prepared to fully participate in the regime and work a full working week.
- Have a minimum of 24 months to NPD/CRD when applying (prisoners transferring to participate in the RAPt programme will be considered with less time if they can complete their course before their release date)
- Be willing to sign a Voluntary Drug Testing Compact


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Emotional Release Through Character Conflicts, An Article By Mary Deal
In order to make that story linger in the memory of the reader—which will make them yearn for your next book—your characters must not only have differences but they might be irreconcilable. Certainly two people in love and having those kinds of problems ache inside. You as the writer must ache with them. You must write that story so that you feel all the pain. If you do not feel the pain, you have not presented a plausible enough reason to keep these two people apart. More importantly, you probably haven't written convincingly enough for your reader if you cannot convince yourself.
If you can write so that you ache for your characters, then can come up with a solution that alleviates your own pain, your reader will feel that same duress and subsequent relief for your characters. You will have raked the reader's emotions over fiction's fire, presented a viable solution, and enticed your reader to remember your byline. Read More


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- +49 241 519 684 82
The Mat woman
Mat is designed for modern women who want stylish clothes that make the most of their figures. More than that, Mat is for women who want to be permanently on-trend, exude happiness, and approach their wardrobe with a joy and a passion for style and living well. Those are the customers who Mat has in mind when their designers create standout fashion. It is a totally contemporary brand for women who love a modern look but don't want to sacrifice the classic tenets of style: great shapes, quality materials. Although it has its beginnings in Greece, Mat is now a worldwide company, and has quickly conquered the international plus size fashion market and won loyal supporters around the globe.
The concept
Mat's talented creative team designs fashion to be mixed and matched, but always keeps a watchful eye on current trends to incorporate in each season's collection. The designers love to experiment with a variety of materials to create looks that are sure to become wardrobe must-haves season after season. Maybe it's the Greek sunshine, but Mat's collections always have a touch of the super-positive: colourful combinations, beautiful detailing and materials you'll love to wear. They combine to make each piece a real wardrobe favourite.
Mat in your wardrobe
In the summer, Mat excels at maxi dresses and cool, wearable jumpsuits. In the winter, it's all about chic coats and sweaters. It's a brand that has got your most stylish interests in mind all year round. We love Mat for its great prints like bright florals and beautiful paisley, its carefully-considered colour palette and its detail like delicate lace and crocheting. At navabi, we focus on Mat's tops, such as their great tunics, blouses and shirts, as well as dresses and jumpsuits. These come in fabrics such as flowing jersey, wearable woven materials, crepe and chiffon. Shop within the colour palette to create complete tonal outfits or mix and match within Mat or with your favourite pieces you already own: this collection is designed to be worn easily but to make you feel your best. Mat excels at basics with a detail, like this black shirt with textured panels.
The label itself
A Greek brand, based in Athens, Mat Fashion was founded in 1988 by George and Marianthe Moneda, whose goal was simple: to set a new standard in the women's fashion business. Its concept was head-to-toe looks built around wearability, that pushed the boundaries of plus size style and gave plus size women access to great looks. It's keeping their collections easy to wear that has enabled Mat to be so successful: these pieces will slip seamlessly into your wardrobe. The brand keeps a close eye on its shoots and styling to ensure that its aesthetic is carried through in all of the Mat promotional material with the same attention to detail that is applied to its clothing. Mat is worn by women around the world, not just in Greece: from Germany to the UK to Cyprus to Ukraine.
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Orders placed on en.navabi.ca, can only be delivered within the following country: Canada. Order on navabifashion.com for delivery address within the following country: USA.
This product includes GeoLite2 data created by MaxMind, available from www.maxmind.com.
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Widely expected, Tales of Xillia 2 was indeed confirmed as the name of the series' next sequel at the Tales of Festival in Japan today. The word comes from producer Hideo Baba himself.
That trailer introduces the new world of Tales of Xillia 2, which does reflect a departure from the sword-and-sorcery motifs of previous entries in the Tales series. There's also this one-minute look at the game's combat.
A Japan release is scheduled for the end of this year; a specific date and price will be announced on June 27. The game is for the PS3. There's no information on any western localisations. The first Tales of Xillia was a Japan-only release.
Tales of Xillia 2 Announced [Andriasang]


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UPDATE: Columbia Task Force Goes On Call For Hurricane Sandy
COLUMBIA - Missouri Task Force 1 was put alert by FEMA in response to Hurricane Sandy on Monday. The alert means the task force has to be prepared to respond to Hurricane Sandy if called. Missouri Task Force 1 will be activated if the Maryland/Virgina, home base task forces need extra assistance helping local residents and state assets. Tennessee, Ohio, and Indiana task forces have been put on alert as well. Maryland and Virgina task forces have also been put on alert on their home base since their states could be physically impacted by the hurricane.
Division Chief Gale Blomenkamp said Missouri Task Force 1 is well equipped to handle hurricanes. "You get a little leeway as far as time versus the natural disaster of an earthquake or even a terrorist attack. Hurricanes are beneficial for us because we can do a little planning and pre-staging."
The task force will be notified in the next 24 hours whether or not it will be activated. The task force is currently preparing its medical cache, pharmaceuticals, and its deployment roster, as well as determining its convoy plans so it can give that information to FEMA. If activated, the task force will have approximately four hours to assemble 80 people, 100 thousand pounds of equipment, and get on the road. Once on location, it would rescue people trapped in homes, as well as tend to building collapses.
There are 26 task forces across the nation. The Missouri task force has been activated before for 9/11, the Republican National Convention, the Joplin tornado, Hurricane Ike, and the Space Shuttle Columbia disaster.
According to Blomenkamp, support agencies such as the American Red Cross are the best way for people in mid-Missouri to get involved to help.
The Fire Department reported that Missouri Task Force 1 was activated at approximately 9 p.m. Monday night. The force planned to deploy within four hours, aiming to arrive in Herndon, VA by 5 a.m. Tuesday morning.


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A little more than three years ago PetFlow.com kicked off its first venture capital fundraising meeting. As we were about to sit down and properly introduce ourselves, one of the senior VC partners looked us dead in the face and said, "What about Amazon?"
It was the same question asked of us at every single fundraising meeting there on out. And our answer always remained the same: "Just because Amazon sells something doesn't mean we can't."
Amazon is an incredible service (I use it quite frequently). After all, Amazon sells just about everything you could possibly purchase. The reality, however, is that the pet-supplies space is a nearly $55 billion industry, with online penetration of less than 4 percent.
"So what about Amazon?" I said. "What about it?"
Here's how PetFlow.com competes:


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Yankees, Cervelli agree on one-year contract
Catcher avoids arbitration with non-guaranteed deal reportedly worth $700K
NEW YORK -- The Yankees agreed to terms with catcher Francisco Cervelli on a one-year, non-guaranteed contract Thursday, avoiding salary arbitration.
The contract is reportedly worth $700,000, but the club has not confirmed the deal. Cervelli is the front-runner to serve as Brian McCann's backup after appearing in 17 games for the Yanks last season, batting .269 with three home runs and eight RBIs.
Cervelli, who turns 28 in March, was expected to catch the majority of the Yankees' games last season and entered the campaign sharing duties with Chris Stewart. Cervelli fractured his right hand on a foul tip in late April and was then suspended for 50 games in August after violating the Joint Drug Prevention and Treatment Program.
Cervelli's agreement leaves the Yanks with four players eligible for salary arbitration, with figures to be exchanged between players and the club on Friday: outfielder Brett Gardner and pitchers Shawn Kelley, Ivan Nova and David Robertson.


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9000 Artist Graphite Drawing Set with Bag
This set of high quality pencils and accessories is perfect for artists on the go. The set includes 12 9000 Graphite Drawing Pencils, dust-free vinyl eraser, and stainless steel pencil sharpener. It also comes with an attractive black nylon pencil bag for easy storage and transportation. Pencil grades included: 8B, 7B, 6B, 5B, 4B, 3B, 2B, B, HB, F, H, 2H.
CASTELL 9000 Pencils have superior leads made of very finely ground graphite and clay, so these smooth, pure graphites are never scratchy. Coated with water-based varnish and SV bonded for break resistance, they will last longer than just about any other pencil.
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Average User Rating: Based on (2 Reviews)
Danielle W. from Cleveland, OH says:
These pencils are great! The quality of my drawings has greatly improved. The amount and quality of these supplies that you get for this price is very hard to beat anywhere!
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Was candidate excluded because of her race?
Republican congressional candidate Liz Carter said she was excluded from a candidate forum last week because she is white. The forum's organizers, who are black, said that's not true. In the complex and often controversial world of Atlanta-area racial politics, such issues are never easy to simplify. PolitiFact jumps into the fray to sort it all out.


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Unique in the Rehoboth Beach area of Delaware, The Rams Head is an all-male, clothing optional resort, bordered by fields and forests, yet is only minutes from the beach, shopping, top-notch dining and more from our private but refreshingly convenient location.
We provide spacious rooms with queen-size beds, private baths, cable television, central air conditioning, refrigerators, and DVD players. An expansive courtyard with a swimming pool, stress-melting jacuzzi, and continental breakfast with modern dining are some of the countless comforts awaiting you. Reliable wifi is also available throughout the premises. A stay with us means you will never have to sacrifice quality to enjoy an environment with others who share your lifestyle.
Please feel free to navigate our website - take a tour, review our rates - and contact us when you're ready for a stay to remember.
Frank and Paul (Maxine, our resident cat, Brok and Colby, our resident dogs) welcome you for the 2013 season!
Rehoboth Beach points of interest:
Enjoy volumes of Tax free shopping at any of the many outlets, visit the specialty shops and retailers in Downtown Rehoboth Beach. Enjoy the boardwalk, clubs, dining and the bandstand in Downtown Rehoboth Beach. Relax or walk the mile long boardwalk or visit Funland. Visit the water parks and movie theatres. Take a walk on the trail to Gordon's Pond located at North Shores Beach ( A state Park). Enjoy a ride on the Cape May/ Lewes Ferry. Lots of fishing charters and jet ski rentals for bay riding located in the area.


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It's time to create beautiful pictures with nature frames. Decorate photos with most amazing photo framing styles. Do you like nature SingleNatureFrames? If yes then now create a wonderful SingleNatureFrames photo album.
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Oreo Scores On Super Bowl Blackout
Oreo managed to turn the Super Bowl blackout into an opportunity to market their famous cookies by tweeting an ad saying 'you can still dunk in the dark.' Horizon Media's Brad Adgate weighs in on Oreo and the best ads of game night. Photo: Nabisco.
This transcript has been automatically generated and may not be 100% accurate.
... the the ... disputes that he's ... been preaching this one ... yes they what I mean this is the first time in the Super Bowl in the red was pretty funny about library Noble warned of tough been born he whispers to the library ... but once the lights went out and thirty five mistake button and ... Twitter ... just said you know you can go in the dock and we had a glass of milk and ... and and an Oreo cookie and he continued to the point was and I got a relatively quickly ... there are a few others that is that he's in he's on a side leaving you plenty of business a long time is that is ... why things are telling is that you come to be like Quek ... and say ok ... this is an opportunity to shore up the two needs a window cleaning ... Joe and I think because it's a super volatile because there was something like twenty three million Twitter comments throughout the whole game you know you wanna be part of a conversation I mean I don't think there's nothing like the Super Bowl this country so ... it was not only an opportunity to come ago when they're ... in a new social media ... but to use it and get ... something very clever to get a huge ... huge up aam ... pushed the feedback from from from viewers of the of the game ... Todd tried to touch it aam now ... shut up these points twice aam was here to learn it or not they did some stuff that wouldn't ... well they did that they actually were also in on Twitter during a black and says you know we can get stains out but we can get you a Black caps ... so that was among the use of Twitter with with the social media ... but they also debut to Procter and gamble and they have that some iconic to feature Joe Montana and Ana ... Ana Jersey now though the wife is a Ravens fan and to sustain a how to get all these people coming like it was a ... year to billion of its trying to turn into something where it was a shroud of fat to muscle up well all of us that we've we've we've seen which was killed and two to five ... well I did like the idea did like the ARIA owing to the unit that like to contact or Taco Bell had a pretty funny and reviews Do geriatric stealing things that he needs to do good impact isn't ... an amazing and when speaking at a nursing home ... I thought that was funny ... no I think most of the most of the color ads are pretty good unit Chrysler have another Oprah ... talk over dinner was with the troops and the new Dodge Ram I'm on on which the farmers ... again ... you know staying in the Super Bowl take McCormick is a lot longer us ... know by five percent of ads on TV our sixty seconds along in the Super Bowl with the ... twenty second of pundits ... and another with Simon and the Audi at was right I mean are you why did just when he hits a lot of boxes right yet thanks to a new threat of a day in my ... best friend and man we appreciate your time tonight ... so how did the civil commercial rate with you Wall Street don't read this ... check out the old likes and dislikes the most suitable ad page on the beest dot com and see if you agree ...


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Alright everyone, I'm back today with some more fun. To kick things off I will start by teaching you "how to draw chibi Palkia", step by step. This chibi Pokemon character is going to be a bit more complex than some of the other chibi style Pokemon figures I've submitted in the past. One of the reasons why chibi Palkia is going to be challenging is because this species is full of detail and definition. As you guys know Palkia is a water/dragon type, and you can see that this chibi version looks so much like the original. Anyways, there's not a whole lot I can say about this Pokemon except have fun learning "how to draw chibi Palkia", I'm sure you will enjoy yourself if you're a fan of the card game or series. Adios amigos, and peace!
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Fried Pork, Basil and Egg ( Put Kaprow Mu Khai Dow )
This is a common dish for Thai office workers, the reason is simple, it is widely available from street food stalls and can be cooked very quickly in a short lunch break. It is also quite spicy so its a great way to pep yourself up for the afternoon. Fried egg is sometimes look down on in the west, but its a staple of Thai cooking.
It originates from central Thailand, but can be bought everywhere, it is medium spicy.
Continue reading "Fried Pork, Basil and Egg ( Put Kaprow Mu Khai Dow )" »


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At Hill And Swift we aim to bring you the widest choice of used cars in Stone, Staffordshire and at great prices. We have some fantastic deals on used SKODA cars, which are always changing. Browse our used cars below and contact us for more information on any of our second hand cars.
We are confident you will not be disappointed with our extensive range of quality new and used cars. At Hill And Swift we can also offer you an extensive range of services and extras meaning that you can buy your new or used car with confidence and peace of mind.
Our showroom in Stone stocks a wide choice of available cars ready for viewing. Contact us today to arrange a test drive.
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Kristi, you are just too beautiful
Someday I'm going to join you!
Next year, I'm there!
I love the happy new year sign! And I am giggling over the last one all over again...
I loved spending time with you too! And when you need a morale boost, just think, "Wazzup!!" He was just the best.
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Brand new and high quality.
Tire valve cap lights screw onto the valve stem of your car,bicycles or motorcycle in seconds.
Universal fitment and easy to install no special wires, can be easily installed and removed.
Fits most valves of road, mountain bicycles, motocycles and cars.
Bright led will turn on while the vehicle is moving and off when stop.
Silver body with ultra bright, long life-span led lights.
Car lights increase night-time and bad weather visibility for safety.
Waterproof, shockproof.
Power by 3 x AG10 batteries.(INCLUDED)
Size: 3.8cm
How do I get them to work for first time ?
You have to unscrew the cap to get to the battery and there is a piece of paper between the spring and battery. Remove it and put back together and they will work on vibration.
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Gilles Peress
Gilles Peress's 'Compulsory Departures' depicts Muslim refugees fleeing Serbian troops in Banja Luka in Bosnia. The photographs were included in Farewell to Bosnia, published in 1994 by Scalo. They have also been included in an exhibition organized by the Corcoran Gallery of Art in Washington DC and the Fotomuseum Winterhur in Switzerland that is the second part of his ongoing project 'Hate Thy Brother': a cycle of documentary stories describing intolerance and the re-emergence of nationalism in post-war Europe. The project has been supported by the Fondation de France.


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XXY (Klinefelter) Syndrome
OverviewXXY syndrome is caused by an extra X chromosome in each cell and has a karyotype (chromosome study) of 47,XXY instead of the typical 46,XY male karyotype. The condition can affect male physical, language, and social development. Although the symptoms vary significantly among affected individuals, the most common features are testosterone deficiency and infertility. If testosterone measures low for age in adolescents, regular treatments with testosterone are usually initiated. Affected children with XXY syndrome may require academic, social, and emotional support.
Historically, XXY syndrome was called Klinefelter syndrome due to a constellation of physical and behavioral characteristics that occurred with the chromosome complement of XXY. With time, it became obvious that many males have the "Klinefelter syndrome" chromosome alteration, but do not have the physical and behavioral phenotypes. In addition to the most typical XXY karyotype, other chromosome abnormalities may lead to a similar presentation. These include XY/XXY mosaicism, where a percentage of cells are normal (46,XY), and a percentage have an extra X chromosome (47,XXY). Individuals with mosaicism may still be fertile, depending on the percentage and distribution of normal XY cells. Although less common, it is also possible to have more than 1 extra X chromosome (e.g., 48,XXXY), which is typically associated with a more severe phenotype and intellectual disability.
Other Names & Coding
Sex chromosome aneuploidy
XXY condition
Q98.0, Klinefelter syndrome karyotype 47,XXY
Q98.1, Klinefelter syndrome, male with more than two X chromosomes
Q98.4, Klinefelter syndrome, unspecified
ICD-10 for Klinefelter Syndrome provides further coding details.
PrevalenceXXY syndrome is the most common disorder of sex chromosomes, affecting approximately 1/1,000 males. [Morris: 2008] Variants are rarer; 48,XXXY is present in 1/170,000–1/50,000 male births. [Visootsak: 2006]
GeneticsBoys with XXY syndrome inherit an extra X chromosome from either their mother or father during formation of the egg or sperm. About half of the cases are from the maternal chromosomes, half from the paternal chromosomes. This is a chance occurrence, and families with one member with XXY syndrome are not more likely to have other affected family members. Mosaic Klinefelter syndrome (46,XY /47,XXY) usually occurs as an error in cell division in a developing embryo.
PrognosisAlthough the range of features is wide, most individuals with XXY will lead normal lives with a normal life expectancy. Boys who have been diagnosed early and who have received developmental therapies, educational interventions, social support, and testosterone therapy may have better outcomes.
Practice Guidelines
Aksglaede L, Link K, Giwercman A, Jørgensen N, Skakkebaek NE, Juul A.
47,XXY Klinefelter syndrome: clinical characteristics and age-specific recommendations for medical management.
Am J Med Genet C Semin Med Genet. 2013;163C(1):55-63. PubMed abstract / Full Text
Roles of the Medical HomeThe medical home provider will need to monitor maturation, response to testosterone therapy, developmental and educational progress, and patient and family adjustment. When the diagnosis occurs prenatally, it is important to counsel families that reports of developmental and behavioral problems associated with the condition are affected by selection bias, as individuals without developmental problems would not usually be offered genetic testing.
Clinical Assessment
OverviewMany men are still diagnosed when, in the midst of leading normal lives, they have a karyotype or chromosome study as part of the workup for infertility. However, when younger children have chromosome testing as part of an evaluation of developmental delay and hypotonia, boys with this condition are being identified as toddlers and preschoolers. The condition is also sometimes identified on prenatal chromosome analysis.
XXY syndrome should be considered in infants and children with developmental delay or in adolescent males who are tall and overweight with fat distributed in a pear-shaped pattern, and who have decreased secondary sexual characteristics in puberty and learning problems.
Of Family MembersSince this condition typically does not run in families, screening of family members is not recommended.
PresentationsCharacteristics of individuals with XXY syndrome evolve with developmental stage:
- Infants may be described as "easy" babies. They may present with hypotonia and show developmental delays in some or all areas (particularly language).
- Toddlers may have continued language delays, or they may be diagnosed with sensory integration disorder, auditory processing problems, and autism spectrum disorder.
- Young boys and teens with XXY syndrome may be taller and less muscular than their male peers.
- Adolescents may experience normal or delayed puberty but have decreased facial and body hair; smaller, firmer testicles; decreased muscle development; and gynecomastia. Depression and anxiety may occur at this age; aggressive or oppositional behaviors may also be seen.
- Older teens and adults may not look different from other males their age, except possibly taller. Low levels of testosterone can cause infertility with normal sexual function and a high-pitched voice. Osteoporosis is often found in older teens and adults with XXY syndrome.
- Hand tremors
- Decreased activity and endurance level
- Sleep abnormalities
- Difficulties in social situations (shy, immature, passive) with low self-esteem
- Learning problems
- Expressive greater than receptive language problems
- Decreased auditory recall
- Easily frustrated
- Higher risk of autoimmune diseases in adults
Differential DiagnosisHypogonadotropic hypogonadism: Males with hypogonadotropic hypogonadism have low testosterone due to a failure of gonadotropin release. Hypogonadotropic hypogonadism can be acquired (e.g., secondary to brain trauma) or congenital. Examples of the latter include Kallmann syndrome (hypogonadotropic hypogonadism and anosmia) and idiopathic hypogonadotropic hypogonadism. In these individuals, the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are low, whereas in individuals with XXY syndrome, they are high. Karyotype results will identify those with XXY syndrome. See Hypogonadotropic Hypogonadism (GeneReviews) for more information.
Fragile X syndrome: Individuals with this syndrome may share some physical characteristics with individuals with XXY, including intellectual disability, autistic features, hypotonia, and tall stature. The two conditions may seem more similar in younger children; in general, they can be distinguished much more easily in older children and adolescents. They can be differentiated definitively by genetic testing, which will demonstrate sex chromosome aneuploidy in individuals with XXY. The Portal's module on Fragile X Syndrome provides further diagnostic and management information.
Marfan syndrome: Individuals with Marfan syndrome, a connective tissue disorder, are tall of stature and may demonstrate hypotonia. Karyotyping will identify males with the XXY syndrome; Marfan syndrome is a clinical or molecular diagnosis based on family history and affected body systems. It is sometimes confirmed with genetic testing for mutations in the FBN1 gene. See Marfan Syndrome (GeneReviews) for more information.
Other overlapping conditions: Especially in younger children, XXY syndrome has a nonspecific presentation that overlaps with many additional genetic conditions, including microdeletion and microduplication syndromes, metabolic disorders such as homocystinuria, and overgrowth disorders such as Sotos syndrome. If routine chromosome studies are normal in a child with features of XXY syndrome, refer for genetic evaluation.
History & Examination
Developmental & Educational ProgressChildren with XXY syndrome may have developmental delays, especially in language development. School performance may be poor specifically in language, and attention problems may be present. [Ross: 2008] Monitor developmental and educational progress and ensure that adequate therapies are in place.
Maturational ProgressMaturation usually begins normally, but unless the individual is receiving testosterone replacement/supplementation, facial and body hair and the expected increase in muscle mass can fail to develop. Maturational progress with the onset of adolescence should be monitored closely by a pediatric endocrinologist. Boys with XXY syndrome are sometimes diagnosed when puberty is delayed. [Zeger: 2008]
Social & Family FunctioningIndividuals and their families may need help with adjusting to diagnosis. Boys with XXY may be withdrawn socially and may need social skills training.
Physical Exam
GeneralIndividuals with XXY syndrome may be quiet, and they may have decreased interaction with the examiner.
Growth ParametersHt | Wt | BMI Boys are usually tall and may have abnormal body proportions with long legs and a shorter trunk. They can have decreased muscle mass and are often overweight. Weight and BMI should be monitored closely with preventative measures taken to avoid obesity.
HEENT/OralLook for abnormal teeth; teeth may often show taurodontism, which is enlargement of the body and shortening of the roots of the tooth. Enamel defects may also be present. [Ramasamy: 2009]
GenitaliaYoung boys may have a small penis and small firm testes, even after adolescent maturation begins. Micropenis is sometimes seen in boys with XXY syndrome, though it is not common.
Neurologic ExamNeurologic exam should be normal, yet hypotonia and a resting hand tremor are sometimes present. Although strength may be decreased in males with XXY syndrome, this is difficult to demonstrate on exam. [Ross: 2008]
Laboratory TestingTestosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) levels, estradiol, prolactin, and insulin-like growth factor (IGF) in the blood may be measured as a baseline and in response to treatment with testosterone. Before treatment, the testosterone level is usually low; LH and FSH levels are usually high.
Genetic TestingKaryotyping will confirm the diagnosis of XXY syndrome. Typically, chromosomes from approximately 20 cells are counted in standard karyotyping, so a low percentage mosaicism may be missed. Additionally, a karyotype of blood cells reflects the karyotype in only one tissue.
Other TestingBone density screening should be performed on a regular basis starting in the teen years.
Specialty Collaborations & Other Services
Pediatric Genetics (see NW providers [1])
Consider a consultation for diagnostic testing and family education.
Developmental - Behavioral Pediatrics (see NW providers [1])
Consider for help in evaluating developmental and academic progress and for suggesting therapies as needed.
Pediatric Endocrinology (see NW providers [1])
Consider referral for ongoing management of testosterone therapy.
Treatment & Management
Pearls & Alerts for Treatment & ManagementFertility treatments
Sperm extractions in conjunction with testosterone therapy have been used with success to allow fertility in men with XXY syndrome. The treatments are expensive and additional measures, such as intracytoplasmic sperm injection, may also be needed.
Treatment is usually initiated at 11 or 12 years of age with testosterone enanthate (Delatestryl) or cypionate (Depo-Testosterone) at 25-50 mg IM q 2 weeks–1 month. It is then increased gradually depending on the degree of virilization, growth, and serum gonadotropin levels, which should decrease with therapy to the high normal range. (Final adult dose is approximately 200 mg IM q 2–3 weeks.)
Once treatment starts, monitor for possible side effects including worsening acne, too rapid sexual development, prostate enlargement, and behavior problems–especially aggression. Transdermal methods of testosterone administration may also be used in older individuals with XXY syndrome.
Note that testosterone therapy does not change the rate of infertility. The option of semen collection and sperm-banking (cryopreservation) in XXY individuals during puberty may be discussed during visits to the geneticist or endocrinologist.
Specialty Collaborations & Other Services
Pediatric Endocrinology (see NW providers [1])
Referral can be helpful for initiation and management of testosterone therapy. Referral to a reproductive specialist may also be helpful in older adolescents and young adults. Referral is often made through the pediatric endocrinologist.
Pediatric Urology (see NW providers [0])
Fertility questions may be addressed by urology.
Development (general)
Specialty Collaborations & Other Services
Developmental - Behavioral Pediatrics (see NW providers [1])
May be helpful in the evaluation and management of developmental delays and behavioral and emotional challenges.
Physical Therapy (see NW providers [0])
May be helpful for addressing gross motor delays and/or lack of abilities and coordination.
Occupational Therapy, Pediatric (see NW providers [0])
May be helpful for fine motor delays and sensory integration problems.
Speech - Language Pathologists (see NW providers [3])
May be helpful for the expressive language delay frequently seen in males with XXY syndrome.
Specialty Collaborations & Other Services
Mental Health Evaluation/Assessment (see NW providers [0])
A full psychoeducational profile to identify strengths, weaknesses, and alternative teaching strategies may be helpful in males with XXY syndrome who are having difficulties in school.
Specialty Collaborations & Other Services
Pediatric Urology (see NW providers [0])
May be helpful in answering questions and managing infertility in males with XXY syndrome.
Mental Health/Behavior
The personality and behavior of boys with XXY syndrome have been described as shy, reserved, sensitive, and passive in childhood, which together with unattended learning difficulties may lead to secondary adaptation and behavioral problems in adolescence. [Sørensen: 1992] [Ross: 2008] Testosterone treatment from puberty may assist in psychosocial adaption during adolescence.[Simm: 2006] [Maggi: 2007] Social skills training, special education services, or provisions in an individualized educational plan for learning problems may also help improve self-esteem. [Samango-Sprouse: 2002] Sometimes, having a diagnosis can help qualify children for services. More details about the personal impact of XXY syndrome and the influence of age at diagnosis, clinical, social, and demographic factors on adult quality of life outcomes can be found in [Herlihy: 2011].
Specialty Collaborations & Other Services
Developmental - Behavioral Pediatrics (see NW providers [1])
Referral may be helpful for social skills training and behavioral problems.
Family Counseling (see NW providers [0])
Referral may help families and individuals adjust to diagnosis.
General Counseling Services (see NW providers [0])
Referral may be helpful in improving body image, self-esteem, mental health, and social supports.
Issues Related to XXY (Klinefelter) Syndrome
Development (general)Normal Pattern of Speech Development
Ask the Specialist
Should all boys with gynecomastia be tested for XXY syndrome?
Gynecomastia is common among adolescent boys. If puberty is otherwise proceeding normally, including normal testicular growth, XXY syndrome is unlikely.
Can I send testing for XXY syndrome, or does it need to be sent by a specialist?
A routine chromosome study can usually be sent from a primary care provider's office. However, most insurance companies require prior authorization for genetic testing.
Is a karyotype (G-banded chromosome study) or a microarray the best test for XXY syndrome?
It depends on how the patient presents. Either test will detect XXY syndrome. If you have a high concern for 47,XXY and don't suspect another condition (as in a teenager with gynecomastia and small testes for Tanner stage), a karyotype will probably be sufficient. The microarray, though more expensive, is a more sensitive test for other chromosome abnormalities. It can be considered as a first step in boys with developmental delay or as a second step for children whose chromosome study is normal, but XXY is still suspected. Prior authorization may be needed for these tests.
Resources for Clinicians
On the Web
Klinefelter & Other Sex Chromosomal Aneuploidies (OJRD)
Diagnosis and management information with short descriptions of 48,xxyy, 48,xxxy, 49,xxxxy, and 46,xx; Orphanet Journal of Rare Diseases.
Genetics in Primary Care Institute (AAP)
Contains health supervision guidelines and other useful resources for the care of children with genetic disorders; American Academy of Pediatrics.
Helpful Articles
PubMed search for XXY (Klinefelter) syndrome in children, last 3 years.
Groth KA, Skakkebæk A, Høst C, Gravholt CH, Bojesen A.
Clinical review: Klinefelter syndrome--a clinical update.
J Clin Endocrinol Metab. 2013;98(1):20-30. PubMed abstract / Full Text
Ross JL, Roeltgen DP, Kushner H, Zinn AR, Reiss A, Bardsley MZ, McCauley E, Tartaglia N.
Behavioral and Social Phenotypes in Boys With 47,XYY Syndrome or 47,XXY Klinefelter Syndrome.
Pediatrics. 2012;129(4):769-78. PubMed abstract / Full Text
Savic I.
Advances in research on the neurological and neuropsychiatric phenotype of Klinefelter syndrome.
Curr Opin Neurol. 2012;25(2):138-43. PubMed abstract
Resources for Patients & Families
Information on the Web
Klinefelter Syndrome (Genetics Home Reference)
Excellent, detailed review of condition for patients and families; U.S. National Library of Medicine.
XXY Syndrome (MedlinePlus)
Brief information about causes, symptoms, tests, treatment, possible complications, and support groups; U.S. National Library of Medicine.
Klinefelter Syndrome (GARD)
Information about cause, inheritance, treatment, and more of Klinefelter or XXY syndrome; Genetic and Rare Diseases Information Center.
National & Local Support
Klinefelter Syndrome Support Group
Links to support groups, information sources, and studies; started by a man who was not diagnosed with XXY syndrome until adulthood.
Clinical trials in XXY (Klinefelter) syndrome (clinicaltrials.gov)
Services for Patients & Families Nationwide (NW)
|Service Categories
|# of providers* in:
|Partner states (6) (show)
|Developmental - Behavioral Pediatrics
|Family Counseling
|General Counseling Services
|Mental Health Evaluation/Assessment
|Occupational Therapy, Pediatric
|Pediatric Endocrinology
|Pediatric Genetics
|Pediatric Urology
|Physical Therapy
|Speech - Language Pathologists
For services not listed above, browse our Services categories or search our database.
* number of provider listings may vary by how states categorize services, whether providers are listed by organization or individual, how services are organized in the state, and other factors; Nationwide (NW) providers are generally limited to web-based services, provider locator services, and organizations that serve children from across the nation.
Aksglaede L, Link K, Giwercman A, Jørgensen N, Skakkebaek NE, Juul A.
47,XXY Klinefelter syndrome: clinical characteristics and age-specific recommendations for medical management.
Am J Med Genet C Semin Med Genet. 2013;163C(1):55-63. PubMed abstract / Full Text
Groth KA, Skakkebæk A, Høst C, Gravholt CH, Bojesen A.
Clinical review: Klinefelter syndrome--a clinical update.
J Clin Endocrinol Metab. 2013;98(1):20-30. PubMed abstract / Full Text
Herlihy AS, McLachlan RI, Gillam L, Cock ML, Collins V, Halliday JL.
The psychosocial impact of Klinefelter syndrome and factors influencing quality of life.
Genet Med. 2011;13(7):632-42. PubMed abstract
Investigates the personal impact of Klinefelter syndrome and the influence of age at diagnosis, clinical, social, and demographic factors on adult quality of life outcomes.
Maggi M, Schulman C, Quinton R, Langham S, Uhl-Hochgraeber K.
The burden of testosterone deficiency syndrome in adult men: economic and quality-of-life impact.
J Sex Med. 2007;4(4 Pt 1):1056-69. PubMed abstract
Morris JK, Alberman E, Scott C, Jacobs P.
Is the prevalence of Klinefelter syndrome increasing?.
Eur J Hum Genet. 2008;16(2):163-70. PubMed abstract
Ramasamy R, Ricci JA, Palermo GD, Gosden LV, Rosenwaks Z, Schlegel PN.
Successful fertility treatment for Klinefelter's syndrome.
J Urol. 2009;182(3):1108-13. PubMed abstract
Ross JL, Roeltgen DP, Kushner H, Zinn AR, Reiss A, Bardsley MZ, McCauley E, Tartaglia N.
Behavioral and Social Phenotypes in Boys With 47,XYY Syndrome or 47,XXY Klinefelter Syndrome.
Pediatrics. 2012;129(4):769-78. PubMed abstract / Full Text
Ross JL, Roeltgen DP, Stefanatos G, Benecke R, Zeger MP, Kushner H, Ramos P, Elder FF, Zinn AR.
Cognitive and motor development during childhood in boys with Klinefelter syndrome.
Am J Med Genet A. 2008;146A(6):708-19. PubMed abstract
Samango-Sprouse, C.
XXY: The Hidden Disability and a Prototype for an Infantile Presentation of Developmental Dyspraxia (IDD.
Infants Young Child. 2002(15):11-18. PubMed abstract
Savic I.
Advances in research on the neurological and neuropsychiatric phenotype of Klinefelter syndrome.
Curr Opin Neurol. 2012;25(2):138-43. PubMed abstract
Simm PJ, Zacharin MR.
The psychosocial impact of Klinefelter syndrome--a 10 year review.
J Pediatr Endocrinol Metab. 2006;19(4):499-505. PubMed abstract
Sørensen K.
Physical and mental development of adolescent males with Klinefelter syndrome.
Horm Res. 1992;37 Suppl 3:55-61. PubMed abstract
Visootsak J, Graham JM Jr.
Klinefelter syndrome and other sex chromosomal aneuploidies.
Orphanet J Rare Dis. 2006;1:42. PubMed abstract / Full Text
Zeger MP, Zinn AR, Lahlou N, Ramos P, Kowal K, Samango-Sprouse C, Ross JL.
Effect of ascertainment and genetic features on the phenotype of Klinefelter syndrome.
J Pediatr. 2008;152(5):716-22. PubMed abstract


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1667 - Anna WEBB died in Northampton, Hampshire County, Massachusetts. Anna was the daughter of John BASSETT and Margery ________. Anna was my 10x-great grandmother.
1692 - Ebenezer BROUGHTON born. Ebenezer was the son of John BROUGHTON and Hannah BASCOM.
1714 - Moses HURLBUT born in Woodbury, Connecticut. Moses was the son of Joseph HURLBUT and Mary CASTLE. Moses was my 7x-great grandfather.
1765 - Samuel CHEW married Margaret TURNER. Samuel was the son of Jeffrey CHEW and Amy DRIVER.
1767 - Magdalene STRADER born in Hampshire County, Virginia. Magdalene was the daughter of Christopher STRADER and Elizabeth BUSH. Magdalene was Corinne's 6x-great grandmother.
1778 - Samuel PIERCE died. Samuel was the son of Seth PIERCE and Bethiah FIELD.
1788 - Samuel BURDICK born. Samuel was the son of Hazard BURDICK and Esther SHIRLEY.
1833 - Andrew Jackson JACOBS born in Brown County, Ohio. Andrew was the son of James Thomas JACOBS and Isabella FEILY.
1836 - Robert H. DEACON married Sarah B. GASKILL in Burlington County, New Jersey. Robert was the son of Joseph DEACON and Beulah HAINES.
1839 - Benjamin Franklin CROCKETT born. Benjamin was the son of John CROCKETT and Susan HAYDEN.
1884 - Luella BALDWIN married John D. RATHFON in Wayne County, Indiana. Luella was the daughter of Cyrus A. BALDWIN and Barbara SHERRICK.
1896 - Ethel KING born in Indiana. Ethel was the daughter of Albert Edward KING and Sarah Emma GEISEL.
1904 - Nancy LeMASTERS died in Salamonia, Jay County, Indiana. Nancy was the daughter of Phillip YOUNG and Nancy Ann McLANE. Nancy was my 3x-great grandmother.
1908 - Mattie SWAFFORD married Napoleon BROTHERTON in Hamilton County, Tennessee. Mattie was the daughter of John Aaron SWAFFORD and Bell SEABORN.
1910 - Isaac LEMASTERS died in Madison Township, Jasper County, Missouri. Isaac was the son of Isaac LEMASTERS and Hannah Elizabeth COLEMAN.
1971 - Charles G. LEE died in Kansas City, Kansas. Charles was the son of Gordon A. LEE and Lucretta REEDER.


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The maps Twitter NYC [spatial.ly] and Twitter Tongues [mappinglondon.co.uk] depict the cities of New York and London respectively according to the languages of the Twitter messages that were broadcasted within their territories.
The New York map, developed by James Cheshire, Ed Manley and John Barratt, is based on about 8.5 million geo-located tweets captured between January 2010 and February 2013. Both cities being major tourist attractions, the resulting maps are actually a combination of the latent language distribution and density of the local population, as well as that from the international tourists.
Via FastCoDesign. More information als available here and here. Details on the data processing here.
See also:
. NYTimes Maps U.S. Census Data in Every City Block
. The World Mapped According to Wikipedia Articles in 7 Different Languages


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You're doing really well considering the pain you're constantly under....and I don't blame you for taking a day or two off. And I'm not ashamed to publically admit that I thought you were secretly 3D printing your buildings..when you were actually scratch building them!!
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How do flowers know to bend toward the sun, plant shoots to grow up, roots to grow down and strawberry seeds to grow red, luscious fruit? Figuring out the exact chemical and genetic steps that command plant cells to grow or divide in response to light or gravity has been one of the longest-standing puzzles of biology.
CHICAGO How do flowers know to bend toward the sun, plant shoots to grow up, roots to grow down and strawberry seeds to grow red, luscious fruit?
Figuring out the exact chemical and genetic steps that command plant cells to grow or divide in response to light or gravity has been one of the longest-standing puzzles of biology.
But now plant scientists are abuzz over a solution reported in Wednesday's issue of the British journal Nature by research teams from Indiana University led by Mark Estelle and a group headed by Ottoline Leyser at the University of York, England, working independently.
They found that the hormone auxin, which is released with exposure to the sun or the pull of the Earth's gravity, combines with a protein called TIR1 to activate a plant's growth genes.
As the discovery opens a new understanding of how plants grow, it could lead to improved crop yields and, perhaps, strawberries as big as softballs. It is also likely to heighten the debate over genetically modified foods.
"This is indeed one of the most important findings in plant biology for many years," said University of Chicago plant biologist Jocelyn Malamy. "These two papers represent a huge step forward--one that was a surprise to many plant biologists--and will have a tremendous impact on plant science."
Charles Darwin had speculated about the existence of a plant growth hormone in his 1880 book "The Power of Movement in Plants." But even after scientists in the Netherlands discovered auxin (derived from the Greek word auxein, to grow) in the mid-1920s, no one could figure out how exactly it triggered plant growth.
Estelle has been trying to solve that puzzle for 20 years. He finally succeeded by studying gene mutations in a plant called Arabidopsis thaliana. Scientists have identified all the genes in Arabidopsis, which is related to broccoli and cauliflower.
Four years ago, Estelle and his team identified the TIR1 protein. Now they are reporting the critical discovery that auxin combines with TIR1 to release the chemical brakes holding back genes that regulate cell growth.
The researchers have mapped auxin's life cycle. The growth hormone is produced in the tips of shoots and branches and in young leaves, where growth is the fastest, though it also travels to other parts of the plant. Roots get a double supply because root tips also make their own auxin.
Auxin enters plant cells to combine with TIR1, and together they remove the proteins locking up the cells' growth genes. After auxin has helped spur growth, it detaches from the genes and is chemically broken down, allowing new chemical brakes to take effect and stop growth.
Despite the new understanding of the machinery of plant growth, auxin remains a big mystery because it does so many other things that have yet to be explained.
"What they found is a central mechanism that eventually is going to be important in understanding how plants perform," said Hans Kende, a plant hormone expert at Michigan State University and a member of the National Academy of Sciences.
"It is not going to have a direct effect on biotechnology in terms of now we can make plants bigger or more efficient," he said. "But down the road it might."
Estelle and other scientists say the new knowledge about plant growth could make food more abundant and nutritious for people around the world.
"The more we understand about how plants grow and develop, the more opportunities there are to manipulate plant growth and development using the tools of genetic engineering," Estelle said.
That possibility is likely to increase concern among opponents of genetically modified foods, who worry that manipulating plant genes may become easier and more widespread. One of their main fears is that genes put into or modified in one plant species may accidentally contaminate other species and cause serious environmental problems.
Although biologists have long been familiar with the growth patterns of plants, the new findings explain the mechanism underlying those behaviors. Flowers, for instance, rotate to face the moving sun because auxin is turned on in some parts of the plant stem and turned off in others depending on the sun's position, Estelle said.
If the sun is shining on the left, auxin is turned on in cells on the right side of the plant, causing the cells to grow and elongate on the right, which bends the flower toward the left and the sun. As the sun moves across the sky, different cells are affected, thereby continually changing the tilt of the flower.
Some plant cells are sensitive to light and others to the pull of gravity; auxin spurs plant shoots to reach for the sun and root tips to grow downward where water and nutrients are found.
Seeds grow into fruit because they make their own auxin, which causes the tissue surrounding them to grow into the flesh of the fruit. The hormone is also responsible for timing when fruit falls from trees. As fruit ripens, the growth hormone declines in the stem securing the fruit, and eventually the stem weakens enough to break. A similar process is at work in the fall to detach leaves from trees.
Auxin is also the reason why cutting off the top of a bush makes it denser. Stopping auxin production in the shoots accelerates hormone production in lower branches.
Despite the new discoveries, auxin hangs on to other mysteries. How, for example, are large doses able to kill broad-leaf weeds, such as dandelions, but leave grass unharmed? A synthetic form of auxin, 2,4-D, became the first effective herbicide and is widely used today.
"Plant growth is a very complicated process," Estelle said. "We've made a big advance in terms of understanding how plants grow, but it's definitely not the whole story."
To see more of the Chicago Tribune, or to subscribe to the newspaper, go to http://www.chicagotribune.com.
Source: Knight Ridder/Tribune Business News


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The 25-year-old, born in Cowbridge, previously played for Plymouth Albion in the RFU Championship while he completed his studies. He made 47 appearances for Albion and was also part of the Wales Sevens set-up.
Watts-Jones moved to Blues in 2012 and has already made 25 appearances for the region in all competitions.
Director of Rugby Phil Davies said: "I'm delighted that Rory has re-signed for the Blues. He came into the senior set-up at Blues two years ago and has really taken his opportunity.
"Over the last few years he has progressed and has represented us in the RaboDirect PRO12, LV=Cup and Heineken Cup. He has been particularly impressive in Europe and was outstanding in the two games with Glasgow this season.
"I'm really pleased that he has committed to a long-term deal and I'm sure he will only get better in the years to come and continue to be a key part of our squad."
Watts-Jones added: "I'm very grateful to have the contract offer from Blues and accept it. Phil (Davies) is a loyal man and he has shown his great faith in me; I want to repay that with my performances.
"This season I feel I have stepped up and looked to take my chance in the first team. I'm a local boy from the region and there is nowhere else I would want to play my rugby.
"Obviously I want to play every single week and you have to really push yourself here. The talent in the back row is clear and while we are very close and get on well the competition is fierce.
"You want to be pushing each other and striving to get better. I like that environment and feel it can only make you a better player."


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Alberto E. Rodriguez/Kevin Winter/Getty
How amazingly desperately pouty was Michael Pitt last night? I'd rather be strumming my guitar smoking cigarettes in a dive hole jazz bar, is this what you're trying to tell me? Before or after you spend your money from modelling for Prada?Yes, Michael Pitt is the face of the new Prada men's campaign Full Story
Pitt & Paz
Michael Pitt showed up at a society event in New York last night alongside the likes of Anna Wintour and Marc Jacobs and pouted with his big lips as though being there was an affront to his artistic integrity. That pubic f-ckery on his face is an affront to my visual integrity. Anyone who grooms their sh-t like that is an automatic please leave my party now. Full Story
Don't torture the artist
Flipping through photos from the Marrakesh Film Festival last night I was overcome with such an overwhelming Sit DOWN BITCH PLEASE I knew I had to share it. This is Michael Pitt of Boardwalk Empire, his hair newly dark, his girlfriend extra hungry, his lips ultra pouty, his expression uber artistic. Full Story


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Hello, new to the forum
Allie wrote:Chopper is unbelievable! What a hunk. I bet all the girlie dogs think he's "Chopperlicious".
One of my good friends has an AB and he is just the biggest sweetheart.
Welcome to the forum.
Why yes, he is quite the hunk isnt he?
All the girly dogs love him. In fact, Ive never seen a dog get so much attention. He rides in the car with me all over the place and it never ceases to amaze me what people will do to work their way through traffic just to get a look at him and either ask me what kind of dog is he or tell me how cute he is.
I just took these picks of him in the back yard.....he's such a camera hog.
He's always smiling.
GQ bulldog
He loves to try and get me to chase him with a stick in his mouth or his toy.
- Wednesday
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Why thank you ladys, Im blushing now.
A few more pics then.
This was the night I picked choppy up from the airport. He was ten weeks old with feet like a Saint Bernard. He was so timid at first but within minutes of getting him home and meeting my little chihahua mut, he came out of his shell and started playing.
He's had my heart ever since.
This was him in his crate right off the turnstyle at the airport....poor baby was terrified.
Dad teaching him how to swim.
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Here is an updated, correct announcement of the upcoming event addressing
the legacy of eugenics in California. If you haven't yet helped publicize
the event, please use this version. Susan Schweik
Eugenics in California: A Legacy of the Past?
A free event open to the public, "Eugenics in California: a Legacy of the
Past?," will take place at the Berkeley Law School on the UC Berkeley
campus (105 Boalt Hall) on August 28, 2012 from 12:30 to 2 pm.
For much of the 20th century, California was at the forefront of eugenic
ideology and practices in the United States, and holds the dubious
distinction of being the state with the highest number of eugenic
sterilizations performed under the authority of law – some 20,000
procedures between 1909 and the mid-1950s. Coerced sterilizations
continued in public hospitals into the 1970s, and it has recently come to
light that in very recent years, women prisoners in California have been
sterilized without their consent or knowledge. Today, California is a
leader in research and services related to human genomics and assisted
reproductive technologies. Speakers at this public event will consider the
long history of eugenics in California and explore continuities and
discontinuities in the uses and misuses of genetic ideas and practices.
Dean Christopher Edley, Berkeley School of Law, will give opening remarks
to welcome attendees.
"Eugenic Sterilization in California: Stories and Statistics"
Miroslava Chávez-García, University of California at Davis, and Alexandra
Minna Stern, University of Michigan
We provide an overview of the patterns of the 20,000 eugenic sterilizations
performed in California state institutions from 1909 to 1979, with close
attention to race, gender, class, and diagnosis. We will also highlight
stories of sterilization victims and the ways in which they attempted to
challenge the state's authority to control and contain their reproductive
rights. As we will demonstrate, the process had a devastating impact on
the victims.
¿Más Bebés? (documentary film)
Renee Tajima-Peña, University of California at Santa Cruz; Virginia Espino,
University of California at Santa Cruz, and Kate Trumbull, documentary
The feature-length documentary ¿Más Bebés? (working title) investigates
the history of Mexican American women who allege they were coercively
sterilized at Los Angeles County-USC Medical Center during the 1960s and
70s. Many spoke no English, and testified that they were prodded into
tubal ligations during active labor. The sterilizations triggered the
1978 class action lawsuit, Madrigal v. Quilligan, and a protest campaign
that galvanized the Chicana feminist movement.
Eugenics in California Women's Prisons Today
Kimberly Jeffrey and Courtney Hooks, Justice Now
Since 2003, Justice Now has been working collaboratively with people in
California's women's prisons to document how prisons violate the
international right to family and function as a tool of reproductive
oppression. Presenters will place a spotlight on personal experience with
as well as the systemic pattern of destruction of reproductive capacity of
women of color and gender variant people in California women's prisons
through several state-sanctioned policies, including forced and coerced
sterilizations (e.g. the illegal and routine sterilization of hundreds of
people in prison during labor and delivery), and other violations of safe
motherhood and reproductive justice.
Should We Worry About a New Eugenics?
Marcy Darnovsky, Center for Genetics and Society
Today's fast-developing genetic and reproductive technologies offer
significant benefits, but can also be misused in ways that exacerbate
existing inequalities and create entirely new forms of injustice.
California, a hotbed of eugenic advocacy in the last century, is today a
center of biotechnology research and commercial development and the
assisted reproduction sector, as well as home to some troubling
techno-enthusiastic ideologies. Our efforts to confront California's
eugenic history can help prevent these dynamics from veering toward a new
CONTACTS: Susan Schweik, UC Berkeley, firstname.lastname@example.com, Marcy
Darnovsky, Center for Genetics and Society,
Co-sponsored by the Center for Genetics and Society and U.C. Berkeley's
Haas Diversity Research Center, School of Law, Institute for the Study of
Societal Issues, American Cultures Center, Disability Studies program,
Center on Reproductive Rights and Justice, and Center for Race and Gender.
This event is wheelchair accessible. Captioning will be provided. To
request an accommodation, please email firstname.lastname@example.com.


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Nissan's compact Sentra plays in an increasingly competitive league, thanks to the growing number of consumers who are gravitating to smaller cars. Within the Nissan lineup, the Sentra occupies the space between the less expensive and slightly smaller Versa and the larger Altima family sedan. The Sentra was redesigned and basically all-new for 2007.
Although the Sentra is small on the outside, its high roofline and 105.7-inch wheelbase (among the longest in the class) yield a spacious and airy cabin that actually puts the Sentra in the EPA's mid-size class. For those over six feet in height, the Sentra may prove to be the best-fitting of the compact segment. Interior design is decidedly modern, but the materials used can feel a bit cheap and actually trail behind those of the less expensive Versa.
The high roofline pays dividends in interior volume, but it also raises the center of gravity, which can give the Sentra a tippy and unsettled feel. In the regular Sentra, the shocks are tuned for a supple rather than sporty ride.
The Sentra comes in several different trim levels. The most basic is the 2.0, with the 2.0S, 2.0SL, SE-R, and SE-R Spec V following in the hierarchy. Two engines are available in the Sentra. The 2.0 models are, not surprisingly, powered by a 140-hp, 2.0-liter four-cylinder engine. A six-speed manual is available, as is a continuously variable transmission (CVT). Fuel economy for Sentras powered by the 2.0-liter comes in at 21 mpg city and 29 mpg highway for the six-speed manual and 24 mpg city and 30 mpg highway for the CVT-equipped model.
SE-R models get a 177-hp, 2.5-liter, and the top-dog Spec V gets a 200-hp version of the same engine. Regular SE-R models come exclusively with a CVT; the more powerful Spec V gets a six-speed manual transmission. According to the EPA, the SE-R will consume a gallon of gas every 24 miles in the city and every 30 on the highway. Spec V versions come in at 21 mpg city and 29 mpg highway.
In a recent comparison test, a Sentra 2.0S finished in last place behind five of its peers: a Toyota Corolla, a Hyundai Elantra, a Honda Civic, a Mazda 3, and a Volkswagen Rabbit. The Sentra's handling and chassis didn't impress.
In a five-car comparison test of sporty compacts, a Sentra SE-R Spec V finished in fourth place ahead of the previous-generation Subaru Impreza WRX—a result that was not without controversy within our office. Although the SE-R Spec V did somehow manage to beat the WRX, it lost to a Mini Cooper S, Volkswagen GTI, and Mazdaspeed 3—cars that all delivered far more driving pleasure and refinement. Furthermore, the Spec V wasn't as quick as the competition.
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Will Wall Street Buy Into the Twitter IPO?
Endpoint Technologies Founder and President Roger Kay discusses challenges facing Twitter in winning Wall Street's favor as it prepares an IPO filing. Photo: Getty Images
This transcript has been automatically generated and may not be 100% accurate.
... the the ... basically said look at a secret Syrian military unit that slow moving stockpiles of chemical weapons ... and making it tougher for the U S a trap ... a fire that engulfed a stretch of the Jersey Shore still smoldering ... and finally our Republic is getting their groove back ... this year GM packs Friday morning News has at times Sara Murray ... but the big news of the morning Twitter filed the paperwork for its highly anticipated initial public offering ... and with it says Claire's fittingly in each week ... Joinus now from whaling Massachusetts to discuss this breaking story is Roger Kay founder and play technologies ... I read it thanks for being here ... mornings are ... still blaming let's get right into what is this mean for Twitter is this can be counted in the test of whether there and injuring technology that can actually make money ... well no not exactly ... leaders going into the company use ... money to ... billion dollars in aid from ... the existing investors ... who would like to get their money out one of the ... company's perspective ... along with a bow ... at ... and we do now I mean we know a little bit about whether they're making money they do these promoted tweets and even in the middle of the top of that we don't really know the de tails of their financial at this point is that right ... that's right so very sketchy ... so there ... we chose to knit a billion dollar ... revenue sometime next year of your after ... ALM so ... so far the company is valued based on insider sales around nine to ten billion ... and the authority in a pretty rich what ... was read to me ... that Facebook ... data going for him ... only so ... probably due to ... an extent she is a good way is a good word to spread offense at this point because ... an index of any kind of took advantage of this relative to titling the rule of the JAB factory can file for an IPO ... and secretly have to disclose any financial information ... write ... a mean that the deal were to lead to the US due to the investor would like to know what the business model is probably going to make money from investors around the Guinea get their return ... and ... not disclosing isn't any way to instill confidence ... that this question in this role that lasted ten and get this ball rolling with the SCC him and telling my anything did this but getting pushed Twitter did to go at this faster ... well I don't know that that that's the reason that a company called in the offering they were supposed to come out sometime next year to the market is pretty rich right now that it's time to be and ... there's no other large offering of right now ... and so why not just take advantage will be running it said ... I've seen in a tech company like this especially since a prank ... the Facebook debacle should have been less control over some The ... was really the wrong saying basically the insiders ... to all the money off the table before the end of the fall apart during college old its people and Republican or finance company ... they needed money and ... that ... Joe ... they've raised billion dollar which has plenty of operating capital ... and their hundreds of millions around the right ... they actually need the money to fund operations it's more like ... the of reading it to pay off the national investors ... that seems like there's a question of our Twitter's model is that we're going for a way to have that nagging tweets that they don't really have the same kind of ... robust ad platform is a Facebook ... Brian ... and I think the way to a cultural difference between Zalando and wallstreeti so nice to be like to see them on in everyone I know ... where it's coming from when it's coming and how it's grown Daimler plans are the future you will see that ... revenue stream ... to make some calculations about the value for their for the stock price and that some investors and use the will to ... nor ... is it a recall to do something like ... that will enable ... soldiers to step down ... and from ... we're going to value his two hundred million users ... then that value something that will be my ... people at some point in the future ... I learned a lesson from when Facebook went through this in this kind of thing flock to the asset what's your prediction for Twitter how do you think this play ... well I hope they're smarter than Facebook or maybe less read it basically to be strongly backing up the price its daily limit on and ... so the initial investor will get me ... it really so that they don't make money they ... lose money on Thursday ... they didn't want to try to only and and that's something all ... work ... Friday thank you very


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NORTH MANCHESTER, IND. – Despite a tough field goal shooting night for Manchester University, the home-standing Spartans nearly picked up a key Heartland Collegiate Athletic Conference win Wednesday, Feb. 19.
Trailing by as much as 10 in the second half, MU (13-11, 10-7 HCAC) started to whittle away at the visiting Defiance College of Ohio lead. A 14-5 run that started with just over six minutes to go gave MU a 45-44 edge with only 49 seconds left after sophomore guard Justine Kruger (Francisville, Ind.) hit a lay-up. DC (10-14, 7-10 HCAC) came back on its next possession for the eventual winning bucket when freshman guard Erica Smay hit her second three-pointer of the game for a 47-45 edge. MU, after a timeout with 11.6 seconds remaining, had a good look for junior forward Abby Lang (Indianapolis, Ind.) on a three-pointer that rimmed out.
The Spartans were guided in scoring by senior forward Erynn Meiklejohn (Fort Wayne, Ind.). She tallied 10 points to go with three assists and a blocked shot, both of which were team highs. Sophomore forward Kasey Reneau (Hagerstown, Ind.) was just off the pace for a double-double with seven points and 10 rebounds, while freshman guard Jenifer Lee (Rockville, Ind.) and Kruger each tossed in six points. MU ended the game hitting at a 35.7 percent clip from the field which included going zero-for-four from outside the arc.
Manchester University, sitting in a tie for fourth with Bluffton University of Ohio with one game to play in the 2013-14 regular season, continues its late-season home stretch Saturday, Feb. 22. Second-place Hanover College comes to Stauffer-Wolfe Arena for a 1 p.m. start.
NOTES: Meiklejohn's double-figure effort continued a string of four successive and five double digits finishes in her last six appearances. Her points per game average is up five-tenths (10.8 – 11.3) in the span … Junior guard Jocelyn Hamilton (Columbus, Ind.) upped her string of multiple assist games to 24 in a row with two. She now has 131 for the season … Reneau registered her second double-digit rebound contest. She ended with 12 against the College of Mt. St. Joseph in early January.


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