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Attending CDC Ebola Safety Training Courses by a Travel Grants
Attending CDC Ebola Safety Training Courses by a Travel Grants
The International society of Infectious diseases (ISID) is highly concerned about what is happening in the West Africa of Ebola outbreak during 2014 that the world celebrating this week the 6 month of its start, they announced a great opportunity of sponsoring a limited number of travel grants to individuals who are attending one of the Centers for Disease Control and Prevention (CDC) Ebola Safety Training Courses. These courses will help in preparing healthcare personnel to provide medical care to Ebola patients in an established Ebola Treatment Unit (ETU) with no harm to him/herself or others remember Safety first so you need to attend CDC Ebola Safety Training Courses by a Travel Grants Read more…
Categories: Home, Infection Control, Opportunities Tags: attending cdc, CDC, cdc ebola, Ebola, ebola safety, infectious diseases, international society, ISID, safety training, training courses, west africa
MRSA: Tedizolid, a New Antibiotic, Proves Effective
Tedizolid phosphate appears to be an affordable alternate to linezolid for the treatment of acute microorganism skin and skin structure infections (ABSSSI): a brief (6-day) course of Tedizolid phosphate was as effective as a 10-day course of linezolid with bear in mind to each early and maintained clinical answers.
Philippe Prokocimer, MD, from Trius medicine in port of entry, California, and colleagues discharged the outcomes of their effectualness and security trial within the Feb thirteen topic of JAMA. The study was conducted from August 2010 through Sep 2011 at eighty one centers throughout North America, geographic region, and Europe. The intent-to-treat analysis encompassed information from 667 mature persons with ABSSSI treated with either tedizolid phosphate (n = 332) or linezolid (n = 335).
Categories: Home, Infection Control Tags: Antibiotics, infectious diseases, MRSA, tedizolid


text: MOVIES Toronto: No Festival Pressers for Canadian Films as Local Talent Bypass Global Press Corps 3:21 PM PDT 9/9/2016 by Etan Vlessing FACEBOOK TWITTER EMAIL ME Getty Images 'The Magnificent Seven' cast The low-key Canucks are sticking to local press junket interviews, leaving a Bell Lightbox grilling to studio pics like 'The Magnificent Seven' and 'Arrival.' Conspicuously absent from the list of official press conferences at the Toronto International Film Festival this year are homegrown Canadian films. The nine moderated and live-streamed press conferences on tap for 2016 include the star-driven cast and directors for The Magnificent Seven, American Pastoral and Arrival, directed by Canadian filmmaker Denis Villeneuve, among other high-profile titles. That leaves no local movies passing through the Canadian festival's Bell Lightbox venue for a critical grilling by the international media after the creative talent preens in front of clicking paparazzi. Low-key Canadians will instead do press junket interviews at the nearby Intercontinental Hotel on Front Street with TV entertainment magazine shows like eTalk and ET Canada and throw some local print queries into the mix to promote their wares. Morley Nirenberg, executive producer of eTalk, a weekday TV entertainment magazine show, said covering the Canadians coming through the Intercontinental lounge complements the broadcaster's equal focus on Hollywood A-listers dominating the spotlight in Toronto this week. "We want to celebrate the Canadians side-by-side with the Americans," he told The Hollywood Reporter. This year's Canadian lineup at TIFF includes three homegrown movies that bowed in Cannes: Xavier Dolan's It's Only the End of the World, starring Marion Cotillard; the Bill Paxton and Colm Feore-starring teen thriller Mean Dreams from director Nathan Morlando; and War Witch director Kim Nguyen's Two Lovers and a Bear, which stars Tatiana Maslany and Dane DeHaan. Toronto fest organizers had no comment when asked about Canadian filmmakers bypassing Bell Lightbox pressers, as did ACTRA, the country's actors union, which has long called for a homegrown star system to help deal with the Hollywood movie machine at the Toronto fest. But Sholeh Fabbri, executive producer of ET Canada, welcomed the stream of Canadian directors and cast coming through their lounge at the Intercontinental. "Our show was built on showcasing great Canadian talent, and I think it's important to celebrate their achievements," Fabbri told THR. The Toronto International Film Festival continues through Sept. 18. FACEBOOK TWITTER EMAIL ME Etan Vlessing email@example.com etanvlessing

subset: commoncrawl


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The Firm's Environment, Energy, and Resources Practice Group is handling a diverse set of matters as the new year commences. From transactional matters to regulatory and compliance cases to hazardous waste investigation and cleanup sites, we are keeping busy.
The Firm has clients who are buying and selling commercial properties. One property is adjacent to or down gradient of more than one Superfund site and will require environmental assessments and carefully crafted environmental clauses for the contract of sale as a result. Another property is the former site of a dry cleaning establishment. Environmental assessments as part of an all appropriate inquiry, and environmental clauses to address the specific circumstances of this site are necessary. Whether our client is the buyer or the seller, we provide guidance to assist in protecting it from the impacts of environmental conditions.
One of the Firm's clients owns property in a heavily contaminated waterfront area in which both the federal and state governments are overseeing and directing cleanups. The ultimate goal of the governments is to get the area cleaned up and developed in a manner that will benefit the entire community. We are negotiating on behalf of our client to accomplish an appropriate and cost-effective investigation and cleanup of the property under the regulatory program that will best suit the client's property-development interests. In addition, since the client purchased the property after the alleged discharge, the Firm will litigate against prior property owners and operators in an effort to recover the costs of the environmental investigation and remediation.
A couple of our clients are potentially responsible parties ("PRPs") at a multi-party Superfund site involving an area of widespread groundwater contamination covering three towns in Nassau County. Currently, we are negotiating with USEPA and the other PRPs the terms and conditions for implementation of the remedial design work.
Soil vapor intrusion is an environmental condition that many property owners in or adjacent to industrial areas are being directed by the regulatory agencies to address. We have several clients facing this issue. One has been directed to investigate a possible soil vapor condition on its property that is suspected to be the result of an off-site source of contamination. We are negotiating an agreement with USEPA that will be implemented by both the owner of the impacted property and the owner of the property that is the suspected source of the contamination. We are drafting a separate agreement between the two property owners that will determine the terms and conditions of their agreement to implement together the Order on Consent with USEPA.
We are finalizing our wetlands permitting work with one client, and advising others with regard to steps necessary before making any alterations to bulkheads, docks, and other waterfront construction.
Finally, we are looking forward to continuing our solar leasing work and our consultations with wind energy companies this year.
The Firm's Environment, Energy, and Resources Practice Group looks forward to another full year advising and guiding our clients.
Posted by Miriam Villani


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We had 11 (eleven) scopes available for observing tonight by the 100+ people in attendance.
Thanks go to Michael Deneen, Tom Vozzella, John Gall, Bryan Stone, Charlie Hall (2 scopes!), Dave Aucoin, John Hobbs, Fred Sammartino, and John Brucker for helping.
Observing started with Jupiter and the moon around 8:30 and moved on to other objects as the night got darker – too many to mention here but it was a large collection of clusters, galaxies, and double stars made available to the crowds. The last people left at 9:45 and 6 of us headed to the '99 afterwards.


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After a long gloomy weekend shuttered at home watching old-fashioned movies and quenching the thirst with new beverages and crazy experiments, a new creation was born;
MOVIE THEATER's COCKTAIL
50Ml Rum Zacapa infused with Sweet popcorn
15Ml Demerara Sugar (1:1)
4 drops Fee Brothers Aztecs Chocolate
Pour all ingredients into a mixing glass with lots of ice and stir it to the perfect dilution. Strain the drink in a rocks glass with one or two ice cubes. Release the oils of a grapefruit zest, and garnish the drink with it.
This drink transports you to another time. The aroma of the grapefruit welcomes you to the theater hall while the classic films are being projected.The screening is paired with popcorn and dark chocolate flavors.
Take a sip and enjoy the experience.


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Neuro-Linguistic Programming (more commonly known as NLP) is an approach to psychotherapy and organizational change based on "a model of interpersonal communication chiefly concerned with the relationship between successful patterns of behaviour and the subjective experiences (esp. patterns of thought) underlying them" and "a system of alternative therapy based on this which seeks to educate people in self-awareness and effective communication, and to change their patterns of mental and emotional behaviour" that was founded by Richard Bandler and John Grinder in the 1970's based on observations of the work of therapists such as Fritz Perls, Virginia Satir, and Milton Erickson.
The term "Neuro-Linguistic Programming" was created to emphasise the link between neurology, language and behavioural change brought about by experience, and can be used to achieve goals in life. NLP is also the science of modelling, or examining successful individuals to see what they did and how they thought to get the results they achieved, creating a model of this via a criteria of steps and reproducing the results by following the same steps, thereby allowing us to attain excellence in the chosen field.
NLP has been used to address issues in individuals such as phobias, learning disorders, unresourceful behaviours and anxiety, to name but a few.
NLP has many popular applications in todays business world, public speaking, negotiation, sports excellence as well as for enabling individuals to access their full potential and enriching their lives.


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I have been following the Patriots for years ever since I was a little boy and I think that this is the wrongest move they had ever made by letting you go.They should gave you what you asked for because you are worth ever penny.You are one of the best player in the NFL.You will surely be missed.
Wes lost his crown…
30 beers…check.
18 pounds of corned beef….check.
Potatoes, Carrots, Cabbage….check
Brand new scally cap from Ireland…check
New Pope …..check
Sign Wes Welker……..what do you mean he's Satan Manning's new go to receiver? That f*cking midget!
Who was Welker before the Patriots? Would he have the stature and respect he has within the NFL if he stayed in Miami? Would he have the numbers both statistically and financially if it weren't for people like Kraft, Belichick and ultimately Brady? So this is how Wes Welker shows loyalty and integrity? You know what? Denver and Horseface Killah can have him. Next season I hope Mayo knocks the rest of his hair off in the middle of the field.
This St Patty's day I will stare down at the crown on my Claddagh ring and toast to loyalty. It's a value we cherish…we're taught this at a very young age here in Boston. It's not bought….it's instilled. That loyalty has played a crucial role in the success of so many Irish and millions of others that came to America for a better life. I don't believe loyalty is passé.
Brady understands loyalty….Wes being so "undervalued" does not.


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We have a number of amenities to make your fishing holiday more enjoyable. To name a few we have got, bar & Restaurant, snooker room with two full size tables, Pitch and putt 9 hole golf course, tennis court……….
Tackle Shop, laundry, shower room, five stretches of the River and last but no means least fishing.


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rf:key Uni reader (OSDP V.2)
Based on the new reader model Relino B PIN Lesers released by the end of 2016, the new rf:key Uni reader is developed with the open protokoll OSDP V.2. Therefore, operating this optically wonderful reader is possible on a hudge variety of access control systems such as Siemens SiPass, Siemens SiPort, Lenel, PCSC, Honeywell, Tyco C-Sure and many others as well. If you have any specific solution in mind, please ask our sales team for recommendations.
Not every manufacturer has implemented the standard OSDP V.2 protocol, so it is likely that some adjustments may have to be made to the reader's firmware. As we develop hardware, firmware, drivers and software ourselves, changes can be made very easily and with a reasonably fast result. Starting at a minimum order quantity of 500 pieces we will be happy to implement your specific demands to the readers firmware free of charge. Any changes made to the OSDP V.2 protocol will be done in close liaison with the manufacturer of your access control software.
When designing this universal reader, we have made a great effort to suit all the needs from the public sector and industrial fields. Our rf:key Uni reader therefore offers a variety of exceptionally great features in one single RFID reader.
Design highlights
- RFID reader for seemless in-wall mounting and easy integration in any standard frame with 55×55 mm.
- Suitable frames are available from every common manufacturer such as Busch-Jaeger, Gira, Merten, Kopp, PEHA by Honeywell, Jung, hager/Berker, Siemens (Delta), Klein, jäger, Legrand, Feller, … and many, many more producers and OEM makes like GAO, Pera, Monte, sygonix, Makel, Viko, Pera, Roth Lange and so on. This is just a short list provided in 2016. As soon as you know which system you are going to use, please ask our sales team for details and a free-of-charge compatibility check.
- Switchable antenna for mounting the rf:key Uni reader either in plastic housing or selectively in metal housing.
- Geeignet für "back-to-back" Montage, das heisst zwei direkt gegenüberliegend in einer Wand montierte Leser stören sich nicht gegenseitig und es kann auch bei ungünstigen Montageorten zuverlässig der Ein- und Ausgang voneinander differenziert werden.
- RFID reader design suitable for back-to-back mounting of two reader (readers opposite of each other won't interfere each other).
- Touch PIN keypad with haptical response beneath the digit "5", adjusted surface feel especially for blind / disabled people (changes to the position and type of haptical feedback are possible, alternatively there's a resistive foil keyboard available instead of the touch keyboard)
Technical details
- RFID base technology: LEGIC® SM4200M
- interface:
- optional version with Magstripe Clock/Data or Wiegand D0/D1 available
- electronically shiftable bus terminating resistor
- firmware / software protocol:
- standardprotocol OSPD v.2
- Magstripe Clock/Data format track 1 oder 2 (by parameter) oder Wiegand D0/D1 format 26 Bit or 56 Bit
- alternatively the rf:key Uni reader is, of course, available with our native rf:key protocol as well (please contact our sales team for more details)
- customer-specific protocols are possible as well, please ask our sales team for your personal offer
- Multi-ISO-reader:
- MIFARE Classic, DESFire (EV1, EV2)
- LEGIC prime/advant
- Integrated slot for SAM module in SIM format
- MIFARE SAM AV2 in SIM format included (can be delivered by the customer itself if preferred)
- sabotage detection
- PIN keyboard:
- capacitive keyboard with haptical ur mit haptischer accentuation under the digit "5" (or otherwise, depends on the customer's needs for the specific project)
- as an alternative to the reader's touch keyboard, there's a resistive foil keyboard available as well on which every single key can be found tactually so this version can be used absolutely barrier-free
Additional technical information
- voltage 8…30V DC (internal inverse-polarity protection)
- connection: 9pin screw terminals
- operating temperature -25°C bis +60°C
- 3 LEDs (green, yellow, red – other colours possible if desired)
- 1 piezo signalling device
- the typical read distance depends on the media used, generally speaking about 1,5 – 10,5 cm (EC format) respectively 0,5 – 5,0 cm (standard-keyfob) and 1,0 – 6,0 cm (original rf:key keyfobs with a large read distance)
Don't set any limits to your creativity! The rf:key Uni reader will look great in a discreet metal environment, it will be outstanding in a modern and colourful interior and even fits in glass enclosures for use in medical applications. As to the switchable antenna it can be mounted nearly everywhere, in plastic frames such as metal housings.
The read distance will typically be around up to 5 centimeters, depending on the type of tag, applicable cryptographic algorithms used and of course depending on the mounting of the reader. Our original rf:key tags with active hardware-based copy protection (real challenge-response-authentication) will typically reach a practical read distance of about 1 centimetre. Using your own technology, especially when using the internal SAM module and your own cryptografic security features, the read distance may differ.
For sure, the well-known security and convenience functions of our rf:key systems (high security tags, random UID, do not track option for suiting works committees) will be compatible with the new rf:key uni reader. As usual on project based devices, all technical data will be clarified by our professionals, the customer's security planner and of course the customer's project team.
Available options:
|Art. xxxx
|colour: white
|price available on request
|minimum order quantity 500 pieces
Further information on rf:key Uni reader:
– data sheet (not yet available)
– installation guide (not yet available)


text: Sullivan Back; Still Hates Palin Calls her book 'manifesto for the imagined life' By Will McCahill, Newser Staff Posted Nov 19, 2009 8:49 PM CST 48 comments Andrew Sullivan. (Wikimedia Commons) (Newser) – The notoriously Sarah Palin-obsessed Andrew Sullivan has restarted his Atlantic blog after taking time off to read her book, and, not surprisingly, he found it ridiculous. "It is," he writes, "a manifesto for the imagined life of an imagined Sarah Palin as a leader for all those who identify with the image and background she relentlessly claims to represent." "The lies and truths and half-truths and the facts and non-facts are all blurred together in a pious puree of such ghastly prose," he huffs before promising to stay on Palin's trail, "that, in the end, the book can only really be read as a some kind of chapter in a cheap 19th century edition of Lives of the Saints. But as autobiography." (Read more Andrew Sullivan stories.)


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The following steps can be used as a guide to perform an Oracle database migration using Dbvisit Replicate. In this example we will use Oracle RMAN to perform the initial data synchronization. Before any migration is done, it is suggested that you run a test on a small database so that you can familiarize yourself with the steps involved. After you have tested on a small database, it is suggested to do a test database with a database that is similar to your production database so that you can now concentrate on the timings involved with the same volumes of data as the production site.
Configure the target database
Step 1
Use RMAN to create & instantiate Target database following one of these methods:
RMAN Duplicate OR RMAN Restore and Recover
Step 2
Run the Setup Wizard as directed and exclude any tables that contain columns that the datatypes are not supported. See Data Discovery - Pre-flight SQL script for datatypes that are not currently supported.
Step 3
After the Setup Wizard is completed, run the *-all.sh script and instantiate the target database as directed in Step 1.
Step 4
Disable all triggers and delete cascade constraints on target database.
Step 5
Start the MINE & APPLY processes to enable target to catch up with source database.
Upgrade the target database
Step 6
Once the MINE and APPLY processes are in sync, shutdown the APPLY process but leave the MINE process running.
Step 7
Perform the Oracle upgrade on the target database as per the Oracle documents and standard procedure.
Step 8
Compile all schema objects and check for any errors.
Step 9
After the upgrade successfully completes once again check the target database to ensure all TRIGGERS & DELETE CASCADE CONSTRAINTS are DISABLED before restarting the APPLY process.
Step 10
Check and correct the TNS_ADMIN variable in DDC configuration files if it has changed during the Oracle upgrade.
Step 11
Restart APPLY process so that target database can catch up to source database, and to confirm that there are no issues.
Cutover to the upgraded target database
Step 12
- Once data is in sync between the source and target databases. Shutdown any applications accessing the Source database.
- Perform a few log switches verify they have been applied then shutdown MINE & APPLY process.
- Shutdown replication (first MINE then APPLY) once SCN is in sync (see console).
Step 13
- Manually migrate any tables with unsupported types ***This requires downtime!!!*** Shutdown & startup the source database first in restricted mode for a consistent export of
- Drop tables that had unsupported types in initial setup on Target. This may require dropping and recreating foreign key constraints on Target & recreating (verifying) they are enabled after import. Datapump impdp with TABLE_EXISTS_ACTION=REPLACE can be also used. The dependencies still have to be resolved manually.
- Run export and imports of these tables once the application(s) is shutdown on Source.
Step 14
Optional: METADATA export/import. This will bring over Packages, Procedures, Constraints, etc if they do not exist on target or you want to be sure the latest copy is there.
You may wish to use this if you have METADATA_ONLY unloads only database object definitions; no table row data is unloaded. Be aware that if you specify
CONTENT=METADATA_ONLY, then when the dump file is subsequently imported, any index or table statistics imported from the dump file will be locked after the import.
One reason you may do this is you want to ensure your PL/SQL (procedure,package,etc.) are up to date on target especially if you have tables/columns that had unsupported types that you migrated in the previous step.
On source
expdp system/ directory=DATA_PUMP_DIR dumpfile=METADATA.dmp logfile=METADATA.log SCHEMAS=
On target
impdp SYSTEM/
Step 15
Compile each migrated schema & generate fresh statistics on Target
SQL> EXEC DBMS_UTILITY.COMPILE_SCHEMA( schema => '');
SQL> exec dbms_stats.gather_schema_stats('',cascade => TRUE);
Migrate Sequences : Generate dynamic SQL to alter sequences from the source database to build the SQL to run on the target database. These sequence #'s should be set to .nextval for each sequence on source database else you may end up with constraint violations if you use these for key generation. See Sequences for more information on this topic.
Step 16
Build dynamic SQL to disable/enable triggers for the target database. (See sample SQL provided below, although your script may vary based on your needs)
spool disable_triggers.sql
select 'alter trigger '||owner||'.'||trigger_name||' enable;'
from dba_triggers
where owner not in (
spool off
If triggers were dropped instead of disabling during instantiation then you will need to extract them from the source database and recreate them on the target database (sample SQL provided below, although your script may vary based on your needs):
DBMS_METADATA.set_transform_param (DBMS_METADATA.session_transform, 'SQLTERMINATOR', true);
DBMS_METADATA.set_transform_param (DBMS_METADATA.session_transform, 'PRETTY', true);
ACCEPT filename PROMPT "Filename for Output: ";
spool &&filename
SELECT DBMS_METADATA.get_ddl ('TRIGGER', trigger_name, owner)
FROM all_triggers
where owner not in (
order by table_owner;
Step 17
Check count of objects and compare the source and target databases(sample SQL provided below, although your script may vary based on your needs):
set pagesize 40000
select owner,object_type,count(*) from dba_objects
where owner not in (
group by owner,object_type
order by owner, object_type;
NOTE: Oracle Bug 9935857 - LOB indexes are missing from DBA_OBJECTS (Doc ID 9935857.8) Versions affected: 188.8.131.52, 188.8.131.52, 18.104.22.168, 10.2.0.4
Step 18
Check count of constraints & compare the source and target databases (sample SQL provided below, although your script may vary based on your needs):
set pagesize 40000
set linesize 200
column owner format A40
select owner,constraint_type,status,count(*) from dba_constraints
where owner not in (
group by owner,constraint_type,status
order by owner, constraint_type,status
Step 19
Check counts of triggers, status and compare the source and target databases (sample SQL provided below, although your script may vary based on your needs):
set linesize 200
set pagesize 40000
column owner format A30
column trigger_name format A30
select owner,trigger_name, trigger_type, status,count(*) from dba_triggers
where owner not in (
group by owner,trigger_name,trigger_type,status
order by owner, trigger_name, trigger_type,status;
Step 20
Continue to do any additional checks on the target server before pointing application(s) to this server and opening for database traffic.


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Pharma R&D Today
Ideas and Insight supporting all stages of Drug Discovery & Development
Review of Alzheimer's Association International Conference (AAIC16) Part 2: Focus on Secretases
Posted on August 24th, 2016 by Patrick C. May, PH.D. in Pharma R&D
In a previous blog, I provided a few thoughts on tau-related drug discovery news coming out of the recent Alzheimer's Association International Conference (AAIC16) in Toronto, Canada. In this post, I will highlight some of the research from the conference on gamma and beta-secretase, which are fundamental small molecule targets for attacking the Amyloid Cascade Hypothesis. Despite some significant failures in past clinical trials with amyloid-directed drugs, targeting this putative cascade remains the prevailing framework for disease-modifying therapeutic strategies for Alzheimer's disease (AD).
Gamma Secretase: "Not Dead Yet"
In a classic original Monty Python movie, a poor villager in plague-ridden London is being offered to the death cart collection despite his protests that he's "not dead yet". Similarly, despite the failures of two gamma-secretase inhibitors (GSIs) in late stage AD trials, gamma-secretase (GS) as a therapeutic target remains a viable strategy. The negative outcomes for these two GSIs, semagacestat and avagacestat, were remarkably similar and included evidence for impaired cognition. Clearly, new approaches to drugging GS are needed.
A better fundamental understanding of GS is required to aide in the discovery of next generation GSIs. As evidenced by presentations at an Emerging Concepts session focused on Secretase Biology, these novel insights appear to be forthcoming. (As an aside, this year's AAIC16 saw a welcome return of basic science to the main program with the appearance of several Emerging Concepts platform sessions). Bart DeStrooper opened the Emerging Concepts: Secretase Biology session with a review of gamma secretase biology and a proposal that GSIs much better than first generation GSIs now could be developed. In particular, a better understanding of the various subtypes of gamma-secretase now allows for targeting PS-1 vs PS-2-containing GS complexes. Given their differential tissue and sub-cellular distribution, this may afford a certain level of substrate selectivity allowing scientists to tailor APP-preferring GSIs for AD and Notch-preferring GSIs for cancer.
Sjors Scheres followed with a cryo-EM analysis of GS which has yielded unprecedented molecular understanding of this multimeric protein complex. These structural insights into substrate binding and active site conformations in the presence and absence of inhibitors should prove as invaluable in designing next generation GSIs as the X-ray crystal structure of BACE1 has enabled development of potent BACE1 inhibitors.
Structural insights could also lead to more rationale design of gamma-secretase modulators (GSMs) which don't inhibit GS per se, but rather shift the cleavage preferences towards shorter forms of Abeta. These GSMs don't interfere with notch-signaling, a process that early GSIs blocked leading to adverse effects. Pfizer presented early clinical data on their GSM, PF-06648671, which yielded significant reductions in plasma Abeta 40 and 42 following a high (360 mg) single dose. A study with multiple ascending doses of PF-06648671 evaluating safety and tolerability as well as CSF ABeta pharmacodynamics is ongoing.
Thus, gamma secretase remains a viable therapeutic target, but not without challenges. In particular, the next generation GSIs or GSMs will need to overcome the stigma associated with this target emanating from the negative outcomes of earlier GSI clinical trials. And if the BACE1 inhibitors currently in clinical trial (see below) are successful, then investing in gamma secretase for AD will become a very hard sell.
The BACE Race
Discovering inhibitors of Beta-secretase, also known as Beta-APP Cleaving Enzyme 1 (BACE1), has been the "Holy Grail" of AD research since the initial description of the proteolytic processing of Abeta from the amyloid precursor protein (APP). Initially cloned in 1999, it took over a decade of research to understand how to drug BACE1, but now there are several potent inhibitors in clinical development.
Leading the pack
Verubecestat from Merck is the BACE1 inhibitor furthest in development. At this conference, there were only a couple of presentations on the baseline characteristics, demographics and biomarker measurements collected at baseline for the trial. The real action for this molecule will be coming next year when the Phase 3 trial is expected to readout. Similarly, BACE inhibitor AZD3293, the Lilly-AstraZeneca joint venture, is in Phase 3 and thus not a lot of new information was presented on this molecule – just some PK/PD modeling and the Phase 1b study in Japanese subjects.
Fast followers
The real excitement at the meeting in the secretase area of research came with the presentations on several new BACE1 inhibitors now in the clinic. While there are several BACE1 inhibitors in development, the molecules from Janssen, Lilly and Roche had the largest visibility at this conference and I will briefly highlight each below.
Janssen had several presentations on JNJ-54861911, a BACE1 inhibitor they licensed in and are co-developing with Shionogi. Along with good safety and tolerability, robust reductions in plasma and CSF Abeta 1-40 were reported in healthy Japanese subjects following a single dose (25-100 mg) or after four weeks daily dosing of 10 or 50 mg JNJ-54861911. Similar plasma and CSF Abeta pharmacodynamics were observed in subjects with prodromal AD (CDR 0.5) or asymptomatic at-risk for developing AD (ARAD) following four weeks of dosing at 10 or 50 mg.
Eli Lilly presented both several posters on the preclinical development of LY3202626 as well as the initial Phase 1 data in healthy subjects and a small study in AD patients. LY3203636 produced dose-dependent reductions in Abeta 1-x as well as proximal biomarkers, sAPPbeta and C99 in transgenic mice, and plasma and CSF Abeta in beagle dogs following low doses of LY3202626. The molecule was safe and well tolerated in Phase 1 trials and extremely potent, yielding 50% reduction in CSF Abeta 1-40 following a single 1 mg dose to healthy subjects.
Roche presented preclinical and early clinical data on CNP520, a BACE1 inhibitor being co-developed with Amgen. CNP520 yielded dose-dependent reduction in brain and CSF Abetas in rat and dog, respectively. Interestingly, in chronic dosing in mouse and other non-clinical species, there was no evidence of hypopigmentation, which is thought to be due to inhibition of BACE2, a highly related protease that is involved in melanosome function. Currently, the other BACE1 inhibitors in development are generally non-selective for BACE1 over BACE2. Given that two of these BACE nonselective compounds, verubecestat and AZD3293, have advanced into late stage Phase 3 trials, the clinical significance of this potential BACE2 inhibition remains to be determined. In first in human studies. CNP520 was safe and well tolerated and following 14 days of dosing produced > 40% reductions in CSF Abeta 42 at doses of 10 mg or higher.
Stumbling at the wire?
While there was much excitement around the excellent early safety and tolerability as well as the robust Abeta pharmacodynamics observed with these multiple BACE1 inhibitors, a word of caution is always necessary. In lessons learned from the gamma-secretase inhibitor development, APP is not the only substrate for these secretases, and while BACE1 appears to be not as promiscuous as gamma secretase, there are a variety of important non-APP substrates described for BACE1 such as neuregulin 1. Despite these potential stumbling blocks, the progression of BACE1 inhibitors into late stage Phase 3 studies gives investigators cautious optimism that BACE1 can be safely targeted. The bigger question is whether chronic reduction of steady state Abeta levels in mild AD will have a meaningful impact on the clinical progression of the disease. The answer to this big question awaits completion of the large Phase 3 trials currently ongoing or about to commence.
Conflict of interest: As a former employee at Eli Lilly and Co, I was involved in the early preclinical development of semagacestat and LY3202626.
All opinions shared in this post are the author's own.
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Patrick C. May, PH.D.
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- New Study Offers Insight into Alzheimer's Disease Research Landscape
- Snakes (aka Chutes) and Ladders – failures and opportunities
- Hopes, Issues, and Concerns in Tackling the Challenge of Dementia
- Working to Uncover the Mode of Action


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A feature of the 1980's was Dúrlas Óg's dominance in Mid under 12 hurling. We followed up our 1979 win by recording an unprecedented and probably never to be repeated twelve in a row of Mid titles from 1979 to 1990. County titles were added in '82, '85, '87 and '89 and who would have thought back in 1989 that it would be our last time to win the county under 12 title. We defeated Toomevara in the '82 final in Templemore by 4-2 to 2-1. The teams were level at half time but second half goals from Brendan Carroll, Padraic Dundon and Graham O'Connor clinched our second under 12 title. Toomevara were also defeated in the '87 final. The '85 final saw us defeat Arravale Rovers in a low scoring (2-0 to 0-3) game at Golden and in 1989 we were victorious over Ballingarry by 1-5 to 0-1.
We won our first Under 14 county hurling title in 1984 defeating our great rivals Toomevara in the final at Borrisoleigh on a scoreline of 3-8 to 3-2. The victorious panel was Brendan Carroll (Capt), Eddie Coman, Padraic Dundon, Damien Woods, Trevor Cooke, Thomas Maher, Clive Hanrahan, Thomas Hayes, Joe Ryan, Richard Corcoran, Seamus Quinn, Gary Purcell, Greg Rafter, Sean Callanan, Pat Jordan, Mark Jordan, Aidan Murphy, Rory O'Dowd, Ken Doherty, Graham O'Connor. Further county titles were added in '85 and '89. We scored a comprehensive win over Knockavilla Kickhams by 6-10 to 4-2 in the '85 final and we defeated Toomevara by 5-9 to 3-2 in the '89 final. We won six in a row Mid titles (1981 to 1986) and also won in 1988 and 1989. Our 'B' team won a Mid Under 14 'B' title in 1989 defeating Loughmore/Castleiney in the decider. This team will be best remembered for their unforgettable display against Moycarkey-Borris in the second round. Moycarkey led by a whopping 15 points at half time but we scored an unbelievable 19 points in the second half to win by four.
Durlas Og County Under 14 Hurling Champions 1984
Back Row (L. to R.): Eddie Coman, Padraic Dundon, Damien Woods, Trevor Cooke, Thomas Maher, Clive Hanrahan, Thomas Hayes, Joe Ryan, Richard Corcoran, Seamus Quinn,. Front Row (L. to R.): Gary Purcell, Greg Rafter, Sean Callanan, Pat Jordan, Brendan Carroll (Capt), Mark Jordan, Aidan Murphy, Rory O'Dowd, Ken Doherty, Graham O'Connor.
Dúrlas Óg created history in 1981 when our under 14 hurlers won the county Feile na nGael title for the first time to qualify to represent Tipperary in the All Ireland finals in Galway. We were hosted by the Castlegar club who had a strong team and proved too good for us. Compensation was at hand, however, when we won first prize for the best turned out team in the parade. Our Feile panel was Andy Rossiter (Capt), Lar Mullaney, Tony O'Mara, Seamus O'Shea, Shane Gleeson, Seamus Maher, Denis Shanahan, George Shaughnessy, Seamus Devaney, Jim Woodlock, Dara Purcell, Mark Shaughnessy, Ger Mockler, Tom O'Sullivan, Joe Loughnane, Gerry Doyle, Timmy Ryan, Ciaran Carroll, Ger Kerrigan, Gerard O'Brien, Ronan Keher, Conor Moriarty. The selectors were Phil O'Mara, P.J. Grace, John Dunphy who served as Club Secretary from 1981 to 1984 and Pat Stakelum. Durlas Óg also represented Tipperary in the All Ireland Feile na nGael finals in 1985 (Wexford), 1987 (Clare) and 1989 (Laois).
Two county and four Mid under 16 titles were won in the 1980's. Our first Mid title was in 1983 followed by further successes in '86, '87 and '88. In 1986 we went all the way and won our first under 16 county title. We defeated Toomevara in the county semi final and Arravale Rovers in the final on a scoreline of 3-8 to 3-5. The winning team was: P. Delaney, J. Ryan, T. Maher, D. O'Shea, P. Jordan, C. Hanrahan, G. Purcell, B. Carroll, S. Callanan, S. Quinn, E. Coman, B. O'Mahony, R. O'Dowd, T. Cooke, G. O'Connor. Subs: D. Woods and K. Doherty. The 1987 county final was a repeat of the '86 decider and we again came out on top by 5-4 to 2-7.
Like our hurlers we also dominated the Mid at under 12 level during to the 80's winning divisional titles each year with the exception of 1984 and 1986. Most years we fielded three under 12 teams and our 'B' team won Mid 'B' titles in 1980 and 1986. Our first county football title was won in 1981when our under 12's defeated Clonmel Commercials in the county final at Bansha by 2-6 to 1-6.. The team was Liam McCormack, Pat Minogue, Bill Mullaney, Paul Gooney, Brendan Carroll, Fionn Stakelum, Kenneth O'Connor, Joe Loughnane, Pat Jordan, Mark Shaughnessy, Paul Mockler, David Tynan, Paul Fitzgerald, Walter Doyle, Brian Mahony. Subs: Michael Gleeson and Stephen Grace. The under 12's won county honour again in 1983 defeating Arravale Rovers by 3-4 to 2-3 in the final. The panel was Ray Corbett, Padraig Dundon, Greg Rafter, Noel Dunne, Gary Purcell, Clive Hanrahan, Donal O'Grady, Graham O'Connor (Capt), Seamus Quinn, Declan Long, Thomas Ryan, Jimmy Chute, Seamus Quinn, Ken Doherty, Barry O'Dowd, Johnny Mahony and Aidan Claffey.
Durlas Og County Under 12 Football Champions 1983
Back Row (L. to R.): Liam Hanrahan (Selector), Jim Corbett, Clive Hanrahan, Greg Rafter, Seamus Quinn, Denis Macken, Padraic Dundon, Raymond Corbett, Gerry Spain (Selector), Seamus Quinn, Aidan Claffey, A. Coman, Noel Dunne, Ken Doherty, Larry O'Connor (Selector). Front Row (L. to R.): Richard Cotter, Lar Barrett, Jimmy Chute, Donal O'Grady, Graham O'Connor (Capt), Gary Purcell, Tom Ryan, Barry O'Dowd, Declan Long, Seanie Mullaney.
The under 14's also dominated the Mid division during the 1980's winning the title each year with the exception of 1986. Our 'B' team won Mid honour in 1985. Despite our dominance at divisional level we won only one county title. This was achieved in 1989 when we recorded our first county football and hurling double. We scored a comprehensive win over Nenagh Eire Óg in the county semi final and this set up a final that was a repeat of the 1987 under 12 decider which was won by Clonmel Commercials. On this occasion we got the better of the exchanges and won by 2-6 to 1-8 at Cashel to go into the record books as the first team from the club to win county under 14 football honours. The victorious panel that recorded a famous football and hurling double in 1989 was Bill Fitzgerald (Capt. football), Pat Murray (Capt. Hurling), Liam Dwyer, Tom Gooney, Tom Fogarty, Melvin Brennan, Gerry Spain, Philip Butler, Raymond O'Dowd, Padraig Barrett, Michael McCarthy, John Callinan, Peter Broderick, Michael Cleary, Gavin Purcell, Jimmy D'Arcy, Raymond Carew, Liam Mockler, Patrick Gleeson, Tom Larkin, Matthew Ryan.
We represented Tipperary in the All Ireland Feile Peil na nÓg finals in 1984 and 1985. The 1984 finals were held in Cavan and we were beaten in the quarter final by St. Eunan's (Donegal). We travelled to Cork for the 1985 finals and we won our first three matches before going down to London.
We won our first Mid under 16 title in 1981 defeating Templemore Eire Óg by 2-5 to 1-4 in the final played at Semple Stadium. The Tipperary Star report stated that "for the new champions, centre-half back Murty Bryan, one of the tallest players ever seen in juvenile games, John Dorney, Peter Mullen, Seamus O'Shea and Ritchie Rossiter did best". Mid titles were won also in '86 and '87.
Tops of the Town
While football and hurling had been the main concerns, there was more to the club than simply games. Dúrlas Óg participated successfully in Scór competitions and a highlight during the early years was always our Tops of the Town competition for juveniles. While the town was divided into four areas (Loughtagalla, Bohernanave, Clongour and The Avenues) some didn't take the geographical boundaries too seriously. Loughtagalla were the inaugural winners. The Scoil Ailbhe Hall was always thronged to capacity for what was one of the highlights of the year.
Club History >


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2019 Second-Hand Uniform & Textbook Buy/Swap/Sell
School Day Tours
Alkira Alumni Association
As part of our 10th Birthday Celebrations, past students of Alkira Secondary College are invited to join the Alkira Alumni Association.
An alumni association is an association of graduates or former students of a college, school or university. Being part of an alumni gives you opportunities to network with old friends, is a source of information about college events, and is an organization through which to organise reunions and celebrations. It also provides an opportunity for you to visit the college to speak to current students, and stay in touch with the college community. Once an alumni association is established, it is usually run and administered by its members. To get the Alkira Alumni Association underway, a team of Alkira staff are starting it up in this, our 10th year. We are hoping to invite as many past students as possible to join in our birthday celebrations in the coming months.
Register your details with us by clicking the link and filling out this form, and help spread the word amongst your old school friends. We'd love to see you all at our celebrations in 2018.
ACAP Comedy Night Fundraiser: featuring The Decent People
Tuesday 4 September, 7pm. All tickets $20.00
Tickets from TryBooking
Alkira Creative Arts Project team bring you a night of improvisation, hilarity and surprise guests. With the spectacular improvisation team, The Decent People, student performers and plenty of audience participation it's the place to laugh, relax and have some fun. Bring a cushion, bring your sense of humour, and enjoy yourselves in our Red Building theatre space, and help us raise money for our annual production in October.
"The Decent People - Sarah Kinsella and Russell Fletcher - are Australian Theatresports Champions and world class improvisers. They can be seen performing in schools, at business events, on TV and at every Melbourne International Comedy Festival. Recently they were the audience warmup act for The Logies. Sarah is currently appearing in the hilarious Grand Exotic Budapescht Hotel for Impro Melbourne, and Russell will be appearing in Ron Elisha's new comedy Unsolicited Male for Q44 theatre."
Community Information Session
Date: Monday 13th August 2018
Time: 6:30 pm - 7:30 pm (light refreshment provided)
Venue: Rangebank Primary School, 14 Lesdon Avenue, Cranbourne
The Department of Education and Training is holding an information session about Victoria's
government education system. Parents and other members of the community interested in
education are invited to attend.
RSVP by Friday 10 August, 2018 by calling 9340 3764 or text 0403 869 232
The City of Case is extremely proud of the job the crossing supervisors do across the municipality to keep our children safe.
Every two years, School Crossings Victoria holds a dinner and awards night, to honour the supervisors from across the state that are recognised by people in the community (including schools), for the wonderful job they do.
Nominations close on Friday 25th May 2018
Date: 17th - 27th September 2017
|Night entertainment
|Day 1
|Sun 17th
|Bus Melbourne to Adelaide
|On the road
|Bus games, rest and relaxation
|Adelaide Shores Caravan Park
|Games night
|Day 2
|Mon 18th
|Bus Adelaide to Coober Pedy
|On the road
|Bus games, rest and relaxation
|Umoona Opal Mine
|Free time
|Day 3
|Tues 19th
|Bus Coober Pedy to Uluru
|On the road
|Uluru at Sunset—time permitting
|Ayers Rock Campground
|Free Time
|Day 4
|Wed 20th
|Uluru and The Olgas
Lunch between walks
|Uluru/Kata Tjuta National Park
|Cultural Centre Activity
Walk around Uluru
(3 hours/13kms)
Walk through the Valley of the Winds
(short walk)
|Ayers Rock Campground
|Free time
|Day 5
|Thu 21st
|Bus Uluru to Kings Canyon;
|Kings Canyon
|Bus games; view landscape
Canyon walk before dinner (20 min)
|Kings Canyon Resort
|Sunset photo opportunity
|Day 6
|Fri 22nd
|Trek Kings Canyon
|Kings Canyon
|Trek through Canyon: Lost City and Garden of Eden (3 hours)
Free time in the afternoon
|Kings Canyon Resort
|Central Oz Has Got Talent
|Day 7
|Sat 23rd
|Bus King's Canyon to Alice Springs
|Alice Springs
|Camel riding about 12 noon
|McDonnell Ranges Tourist Park
|Free time
|Day 8
|Sun 24th
|Alice Springs Desert Park
|Alice Springs
|Desert Park; Rex's Reptiles;
After lunch: School of the Air & Royal Flying Doctor service
|McDonnell Ranges Tourist Park
|Trivia Night
|Day 9
|Mon 25th
|Western McDonnell Ranges
|Alice Springs
|Simpsons Gap; Standley Chasm; Namitjira's ghost gums; John Flynn's gravesite.
Team Photo (Look Your Best in your Camp Polo)
In the afternoon: free time shopping in Alice Springs
|McDonnell Ranges Tourist Park
|Outback Oscars -
Don't forget to wear your costume!
Thank-yous and camp awards
|Day 10
|Tue 26th
|Bus Alice Springs to Melbourne
|On the road
|Bus games, DVDs and resting
|The Bus!
|Movie night on board
|Day 11
|Wed 27st
|Bus Alice Springs to Melbourne
Breakfast at McDonalds Horsham
Arrive at school
late afternoon!
|On the road
|Bus games, DVDs and resting
Year 9 Camp - Anglesea
Location: Great Otway National Park - Cape Otway
Date: 13th - 15th November 2017
Parent Information Evening - Wednesday 26th July 5:30pm
Deposit due: 11th August 2017 - $100
Total cost $450 - payment plans available


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alderley edge, Aubergine dish, bramhall, cheadle, cheshire, chorlton, disley, england, food, Karniyarik, manchester, marple, mellor, turkish food, turkish food recipe
Karniyarik ( eggplants with minced meat filling ) is very popular summer dish when the aubergines are ripe and tasty.
You need 6 or 8 long aubergines, 300 gr minced meat, 6 medium size ripe tomatoes, 2 medium onions, 8 garlic cloves cut small pieces, 1 bunch of parsley, 2 red pepper cut vertically 8 pieces, 1/2 cup sunflower oil to fry aubergines. Here is step by step how you cook Karniyarik pictures. Afiyet Olsun ( Bon Apetite)


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Gianni e le donne
Gianni is back, and better than ever. Or is that worse? Sequels are historically disappointing, but I'm glad to say that Gianni e le donne (released in English as The Salt of Life) — Gianni Di Gregorio's follow-up to Pranzo di ferragosto (released in English as Mid-August Lunch) — is an exception. I found his previous outing good but not great, but with an interesting, pseudo-autobiographical approach not unlike Larry David, but far less tense and harsh. I'm glad he's gotten another bite at this apple, and that this time he's nailed it.
Gianni may not be in a crisis of debt this time around, but he's still struggling with life as an early pensioner, and still stuck caring for his mother (Valeria De Franciscis Bendoni), now in her mid-to-late nineties. After he and his lawyer friend Alfonso (Alfonso Santagata) flub an attempt to get him power of attorney for his mother, Alfonso decides that what Gianni really needs is not more fiscal breathing room, but an affair.
And really why not? Gianni is sixty, not dead. His wife and daughter don't seem to have much use for him beyond rides to Ikea for curtains. He gets on better with his daughter's boyfriend than with either of them, and signs point to him not being around for very much longer.
So Gianni decides to give it a go. Of course, he's the opposite of the usual author-figure — a hapless sad-sack who would make Charlie Brown feel sorry — and so nothing goes as planned. His mother's caretaker dreams of him, but as her grandfather; the daughter of his mother's friend only has eyes for even younger men; his college girlfriend falls asleep. Alfonso tries setting himself and Gianni up with twins, which doesn't fail quite so badly as his other attempts. And, of course, whenever you talk about an aging man and sex there are international treaties requiring at least one Viagra gag.
Gianni isn't the usual "last sane man", either. His circumstances may be absurd at times, but it's a particularly banal absurdity, which Gianni endures because, hey, what else are you gonna do? Oddly, the story benefits from removing the specific goal he had in Pranzo di ferragosto; the obstacles aren't so frustrating and don't feel quite so contrived. Everyone can relax and just get with it, wondering what on Earth this poor man can be thinking.
With a broader cast still consisting mostly of what seem to be amateurs, there's more room for some embarrassingly amateurish performance. And yet instead we find a refreshing sense of naturalism. Gianni himself is no amateur, but he has surrounded himself with a cast with whom he can feel comfortable, and that makes his own performance work without feeling forced.
I'm certain that it's possible to go through life without watching movies like this one; it's even possible to be sustained and nourished without such light fare as this on the menu. And yet such a life wouldn't be nearly as worth living as one that includes a judicious dash of salt.
Worth It: yes.
Bechdel Test: fail.


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Puteti semna si dv petitia reprodusa mai jos, la adresa
http://www.petitiononline.com/mod_perl/ ... 21ian205&1
To: International romanian community and friends
Dear Madam/Dear Sir,
We appeal to you in order to draw your attention regarding the situation of a church built in Malainitsa (northeastern Serbia) by the local Romanian community.
On January 21, the mayor of the locality submitted an official letter to the curate of the church, ordering him to destroy the belfry until January 28 and to proceed with the demolition of the church within 15 days.
This order of the mayoralty is based on the pretense that the church's construction was not approved by the local authorities. The fact is that no building in the village Malainitsa was ever constructed following such a procedure. The Romanian church is the first case when the authorities demand the completion of an approval procedure. Given the situation, this is clearly an unreasonable requirement directed in fact at preventing the Romanian minority to develop its own religious life. The church is built on a private property and no property issues are involved in the matter.
The general framework regarding Romanians in Serbia is confusing. They live compactly in two areas of Serbia. The group in northwest (Vojvodina) is officially recognized as a national minority and is therefore granted all the specific rights of a national minority. The group in northeastern Serbia (the Tymok Region), is officially ignored and, in consequence, no language, education or cultural rights are available for them.
The intention of the local authorities to proceed with the demolition of the church is wrong, immoral and ultimately illegal. Although the Romanians in Malainitsa might have broken some formal legal provisions concerning the need for an approval, such a requirement for them is unreasonable because nobody in the village was ever demanded to obtain such an approval for a private building, as it is usually the case in the countryside. Setting up unreasonable requirements for a minority group in comparison with the usual requested for the majority is a violation of the spirit of the international legislation regarding the protection of national minorities.
In the particular case of the church in Malainitsa, the Serb authorities are clearly in breach of the following provisions of the Council of Europe's Framework Convention for National Minorities:
- article 4, regarding the promotion in all areas of social and cultural life of a "full and effective equality between persons belonging to a national minority and those belonging to the majority"
- article 5, regarding the obligation of the state "to promote the conditions necessary for persons belonging to national minorities to maintain and develop their culture, and to preserve the essential elements of their identity, namely their religion, language, traditions and cultural heritage"
- article 8, regarding the obligation of the state "to recognize that every person belonging to a national minority has the right to manifest his or her religion or belief and to establish religious institutions, organizations and associations".
Hoping that everyone of you can help us to publicize this matter and determine the serbian government to undertake the appropriate measures, we thank you for your consideration.
The Undersigned


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Tuesday, October 11, 2011
Paintings inspired by Pop culture and folk-by Prithvi Soni
Posted by Johnson Thomas at 12:13 AM
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Labels: art, folk art, Johnson Thomas, paintings, pop culture
Akshar Ganesh Art
ere's an artist who can create Ganesh art from almost any letter / number - Akshar Ganesh Art Awesome talent - must see!!http://www.youtube.com/watch?v=UGy2TFmS95c
Posted by Johnson Thomas at 12:06 AM
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Labels: Akshar Ganesh Art, art, Johnson Thomas
Monday, October 10, 2011
Walkthru with Atul Dodiya
Posted by Johnson Thomas at 11:14 AM
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Labels: art, Atul Dodiya, exhibition, Johnson Thomas
Saturday, October 1, 2011
The Art of drawing curated by Sunil Patwardhan
The Art of Drawing Curated by Sudhir Patwardhan Dilip Ranade Gieve Patel Himmat Shah Jyothi Basu K.G. Subramanyan Krishen Khanna Parag Tandel Sudhir Patwardhan Tushar Joag Vilas Shinde The Guild, Mumbai Preview: Friday, October 7, 2011 | 7- 9 pm On view till October 15, 2011 www.guildindia.com The Guild is pleased to present the preview of The Art of Drawing, curated by Sudhir Patwardhan. The exhibition is a preview of a two part exhibition at Sudarshan Art Gallery, Pune "The impulses behind drawing, the reasons why artists draw, are multiple and varied, and the drawings that result from such varied impulses look very different from each other. A studied rendering of a model in the studio is different from a quickly rendered sketch of a figure seen in the street. An idle doodle is different from a charged venting of emotion on paper. Drawings done to clarify a vague idea in the mind are different from drawings done to abstract the essential forms in nature; and the list can be as long as the number of artists who do drawings. However, till not too long ago, the activity of doing some form of drawing daily was considered essential for every artist. It was part of the discipline of being an artist and was considered the foundation on which an artist built. It was essential for keeping the connections between eye, brain and hand alive and alert. In the last few decades drawing seems to have lost this generally accepted eminence in the creative process. Firstly, with the spread of photography from the beginning of the twentieth century, the reign of one kind of naturalistic or academic drawing came to an end. Nevertheless, drawing still flourished in the modern period. Artists found new uses for and purpose for drawing. And the forms that drawings took multiplied. In the past twenty years or so however, with the advent of the new media in art - video, photography, installation etc. and the spread of the computer in design and architecture, drawing seems to have receded somewhat from artists' practice. Its position in the academic curriculum too is unstable and its need is not universally felt. The purpose of this exhibition is to bring together some of the different kinds of drawing done by Indian artists today. Drawing may have lost its position as the foundation of all art, but it is still widely practiced, even passionately pursued. Works by the ten artists in this exhibition were chosen with a view to give the viewer some sense of the variety of ways in which drawing is still used as a tool of exploration, and as a mode of expression. We hope the viewer will experience the potency of the drawn line in its different avatars, and also experience the key position drawing can occupy in the creative process of different artists."– Sudhir Patwardhan The Guild 02/32,Kamal Mansion, 2nd floor ArthurBunder Road,Colaba Mumbai 400005 +91 22 2288 0116 / 0195 adminoffice +9122 2287 5839 /6211 fax + 91 22 2287 6210 www.guildindia.com
Posted by Johnson Thomas at 8:01 AM
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text: MOVIES Inside LACMA's Stanley Kubrick Retrospective: Director's Obsession With Detail on Vivid Display 7:59 PM PDT 10/24/2012 by Fiona Murray FACEBOOK TWITTER EMAIL ME Stanley Kubrick on the set of "2001: A Space Odyssey" At a preview of the exhibit, which opens Nov. 1, the filmmaker's widow described his fetish and revealed why he never went on talk shows. As famed for his filmmaking as he was for obsessive perfectionism, it should come as little surprise that master director Stanley Kubrick carried out painstaking research, all catalogued on an elaborately detailed paper trail, before the camera ever rolled. This relentless devotion to detail and his craft is showcased in Los Angeles County Museum of Art's "Stanley Kubrick," the first retrospective of the late filmmaker's work in the U.S., an exhaustive collection of photography, costumes, artifacts, technical equipment and personal ephemera that provides fascinating insight into the mind and machinations of one of the greatest — and arguably the most influential — directors of our time. PHOTOS: Stanley Kubrick: A Retrospective of His Films Speaking at the press preview Wednesday, Kubrick's brother-in-law and film producer Jan Harlan described the exhibit — which was compiled by a team of archivists who scoured the director's trunks and personal letters for years — as an enduring personal record. "With Stanley, as with all great artists, the genius doesn't disappear," he said. And being a true artist — one described by Steven Spielberg as his generation's "the big bang" — it makes sense that Kubrick's work also should be seen in a museum. Also visiting from London as a LACMA special guest was Kubrick's widow, German actress and singer Christiane Kubrick. "Here are the remnants of somebody who didn't have a computer," she said. "Even though he was one of the first people to have one, this was just before. "The things that are left are on paper and hand-touched. You put them in a glass box and you go all gooey — that's what a fan is," said Kubrick, who fell in love with the director after he cast her in his 1957 film Paths of Glory. A talented artist, Christiane Kubrick's paintings were featured throughout the apartment of Tom Cruise and Nicole Kidman in Kubrick's highly controversial last film, Eyes Wide Shut. STORY: Nicole Kidman on Life With Tom Cruise Through Stanley Kubrick's Lens "Stanley needed a New York flat for a couple with a good income, and our flat was one of those," she recalled. "And he hated inventing something that everybody knows — you make mistakes so easily — so he said, 'Why don't we just copy our flat?' The version in the film is slightly more posh than ours, but he took my paintings and my jewelry and my clothes … it was a sort of a fetish of his to make night tables and kitchens and darker corners of households look real. And he was also lazy, so he used my stuff!" The director's talent for realism and visual storytelling can be viewed in the exhibit's collection of images from his first job as a staff photographer for Look magazine. Having never gone to college, Kubrick started work as a photojournalist at 16, and the early black-and-white images of boxers, showgirls, housewives in a Laundromat and street kids (alongside his 1947 on-set press pass for Jules Dassin's crime drama The Naked City) are worthy additions to his oeuvre, highlighting a young Kubrick's empathy for subjects and their struggles. Kubrick maintains that it's a common and crazy misconception that her husband was cold and did not like being around people. "He was the opposite of a recluse, he was all over the place," she said. "He was just not into so-called showbiz watering holes. He talked a great deal -- his intensity was what made him very special, more interesting than most people -- and he knew that gave away a lot. If you can't shut up because you get so carried away, people can milk you -- you are far more vulnerable. "He didn't go on chat shows, he was like, 'I see all these other bastards doing this, but I'm so afraid, I'd be too nervous to function properly. I don't have the talent to sell myself well. Good directors are not actors.' And he had such a sense of humor; I could no longer watch the news after he died, because I had this wonderful political cabaret going on. People fell in love with him because he was very funny -- and nice. Nice is good! And love goes a long way." VIDEO: 'Moonrise Kingdom' Director Wes Anderson on 'Stealing' From Kubrick, Polanski Each of Kubrick's cinema masterpieces, including A Clockwork Orange, 2001: A Space Odyssey, Barry Lyndon and The Shining, is honored with an assemblage of original costumes, props, set pieces and hand-scribbled storyboards and scripts. But perhaps the most telling of his unnerving devotion to research are the materials gathered from the masterwork that was never made: his Napoleon biopic, which Kubrick was forced to abandon in the '70s because of budget and production challenges. Years of extensive research into the minutiae of the French emperor's life is glimpsed in glass cases bearing multiple draft scripts; Napoleon handwriting facsimiles and an elaborate color-coded filing system cataloging his known acquaintances; Kubrick's 1971 draft letter to studio execs, telling them, "It's impossible to tell you what I'm going to do except to say that I expect to make the best movie ever made'; his offer letter to Oskar Werner for the title role; and a very polite hand-written inability letter from actress Audrey Hepburn, stating that she had decided not to work for a while, but "will you please think of me again someday?" Sadly, it was all not to be. The exhibit runs Nov. 1 through June 30 and will be paired with a retrospective of Kubrick's work at LACMA's Bing Theater from Nov. 9 to Dec. 15. The Academy of Motion Picture Arts & Sciences will stage a "Salute to Stanley Kubrick," hosted by Clockwork Orange star Malcolm McDowell, at the Samuel Goldwyn Theater on Nov. 7. FACEBOOK TWITTER EMAIL ME Fiona Murray firstname.lastname@example.com @thr


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Thousands of people gathered in Durban from across the world this Saturday in a large march including civil society, youth movements, faith groups, union members, women's rights activists, artists ,community voices like Indymedia etc..
According to protestors the aim of the march was to take their memorandums to UNFCCC Chief Christiana Figueres and COP17 President Maite Nkoana-Mashabane.
Groups gathered early morning in all streets of Durban behind Hillton Hotel , with their t-shirts singing songs and slogans.
Heads of state and ministers are expected to join the COP-17 this upcoming week
Eric Kayihura


text: NEW DIGS ON THE BLOCK World-weary travelers, meet your new best friend: Jen. Upping the hotel game in Manila is the latest offering from the Shangri-La hotel brand catering to a new "Jeneration" of independently minded business and leisure travelers. That means you—if all you really want from your hotel is quality, comfort, value, honest […] More here: This week in travel


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You are here: LeadvirusWarm Welcome
Warm Welcome
Welcome to Leadvirus. There has been a long wait period about the successful launch of the services. We have heard lots of questions from customers world wide about the relaunch of the services and haven't been able to update about the services. We have thus set up a blog portion on the website to update you about the continuous progress and growth of leadvirus project. We have plan to make leadvirus a global brand in email marketing and email delivery by year 2014. We have taken steps in this regard and keep our visitors updated about the success of our goal through the blog section of the website.


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'Moa's Ark' set sail 80 million years ago. David Bellamy becomes an ancient mariner and retraces the voyage of the islands of New Zealand (using contemporary science as his guide). In this first episode he finds out why New Zealand is called the Shaky Isles, gets face to face with the "living fossil" the tuatara, is inspired by meat pies, and discovers geography as he competes in the annual Coast to Coast race over the Southern Alps — with directional and gorse eradication aid coming from legendary race organiser Robin Judkins.
In July 1998 Shortland Street added a tragically memorable entry to its catalogue of births, deaths and marriages. Pregnant nurse and fan favourite Tiffany (Alison James) is out shopping, when she sees suicidal patient Tim (Kelson Henderson) heading for the roof of a high rise. She races up the stairs and successfully talks him down, but then she falls. Knowing she is badly injured and brain-dead, her husband Johnny Marinovich (Stelios Yiakmis) has to make the difficult choice between letting her go, or keeping her on life support until their baby is born.
Jock Phillips begins his journey through our Waitangi collection by recalling an awkward encounter with a security guard at the treaty grounds. Wandering 50 years between the first film in this collection and the last, Phillips explores changing attitudes to the Treaty. Discover everything from Mike King on the treaty trail, to trench warfare, waka-building and epic drama.
As a showcase history of Christchurch on screen this collection is backwards looking; but the devastation caused by the earthquakes gives it much more than nostalgic poignancy. As Russell Brown reflects in his introduction, the clips are mementos from, "a place whose face has changed". They testify to the buildings, culture and life of a city now lost, but sure to rise.
This collection celebrates more of the legendary TV moments that Kiwis gawked at, chortled with, and choked on our tea over. In the collection primer Paul (Eating Media Lunch) Casserly chews on rapper Redhead Kingpin's equine advice to 3:45 LIVE! and mo' memorable moments: from a NSFW Angela D'Audney to screen folk heroes Colin McKenzie and the Ingham twins.
Animated plasticine. Talking chickens. Dancing Cossacks. Plus old favourites bro'Town, Hairy Maclary and Footrot Flats. From Len Lye to Gollum, feast on the talents of Kiwi animators. In his backgrounder to the Animation Collection, NZ On Screen's Ian Pryor provides handy pathways through the frogs, dogs and stop motion shenanigans.
This collection celebrates a decade of NZ On Screen, and the most viewed titles for each of those 10 years. Britten – Backyard Visionary was the first; its popularity continues today. The naughty kea crashed the site the next year, and of course you must remember: "always blow on the pie". The loss of some legends saw user numbers swell, and you just can't get enough of great ads. To mark the anniversary, check out pieces by past and present NZ On Screeners Brenda Leeuwenberg and Paul Stanley Ward, NZ On Air's Jane Wrightson and ex board member Roger Horrocks.
Billy Taitoko James is a Kiwi entertainment legend. His iconic 'bro' giggle was infectious and his gags universally beloved. This collection celebrates his screen legacy, life and inimitable brand of comedy: from the skits (Te News, Turangi Vice), to the show-stealing cameos (The Tainuia Kid), and the stories behind the yellow towel and black singlet.
New Zealand's representatives in parliament have had some of their most memorable moments captured on camera. This collection showcases their screen legacy: from stirring addresses (Kirk), feisty debates (Muldoon, Lange, Olympic boycotts), revolutions, nukes, and snap elections, to political punches (Bob Jones), and young leaders (Clark). Listener writer Toby Manhire writes about Kiwi politicians on screen here.
Actor Kevin Smith could do it all; from brooding like Brando in a Tennessee Williams play, through Xena, to the gentle romantic lead of Double Booking, and self-parody in Love Mussel. Collected here are selections from a career cut short (he died in a 2002 film-set accident). Plus tributes from James Griffin, Michael Hurst, Geoffrey Dolan and Simon Prast.


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From exclusive Pokemon & Street Fighter merchandise to limited edition lines from luxury fashion brands, here's our list of the top things of what to buy in Japan.
#1 Starbucks Christmas Merchandise
Starbucks Japan is famous for their pink sakura tumblers and mugs, and this Christmas, the lifestyle brand brings to us yet another collection of drool-worthy keepsakes. Featuring pastel hues and whimsical illustrations, here's a peek at Starbucks' winter merchandise:
#2 Universal Studios Japan Merchandise
The theme park is a wonderland for Japan-exclusive souvenirs! From Minion buckets to Harry Potter-themed trinkets, you'll be able to get limited edition finds for almost all the characters in the Universal Studios world. Our favourite is the super cute Bob Minion Bucket (Singapore sells a slightly different Minion!).
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. ☆ ☆ ☆ ミニオンペットにしてバズと 仲良くさせたい💭 ☆ ☆ ☆ #usj#goproのある生活 #couple#カップル#ゴープロのある生活#ゴープロ#ゴープロ女子#l4l#写真好きな人と繋がりたい#カメラ好きな人と繋がりたい#写真撮ってる人と繋がりたい#コーディネート#オリンパス#カップル写真#いいね返し #ゴープロ持って出かけよう #空#wtw#ロンハーマン#ユニバ#bff#いいね#カップルフォト#カップルコーデ#ファインダー越しの私の世界#ゴープロカップル#ユニバーサルスタジオジャパン#リンクコーデ#followme#すきっぷすきっぷらーんららん💓💓💓
#3 Macdonald's Limited Edition Game Sets
To celebrate the 30th Anniversary of the Happy Meal, Macdonald's Japan has released limited edition versions of the most popular games from our childhood! There's Game of Life, Uno,Twister, Monopoly, Pop-up Pirate, and poker playing cards. (From Nov 17 onwards.)
Video credit to Mattel / マクドナルド公式(McDonald's) via YouTube.
[RELATED] Lusting over these Japan-exclusive buys but no plans to travel anytime soon? Get someone to bring it back for you! Check out Airfrov; a marketplace where you can put up a request for travellers to help you purchase stuff you can't get locally.
If you're the one travelling, why not help others with their shopping and earn some spare cash to cover your travel expenses! Interested? Scroll down for an exclusive promo code.
#4 Bulgari x Jojo's Bizarre Adventure Range by Hirohiko Araki
With a previous Gucci collection under his belt, Japanese manga artist Hirohiko Araki has outdone himself again with an exclusive Bulgari range. Featuring illustrations of the cast from Jojo's Bizarre Adventure (including the popular Killer Queen, an abstract concept character), there's everything from bags and wallets to scarves and other accessories.
#5 Crestbridge (Formerly Burberry Blue & Black Label)
If this sounds foreign, it's probably because you know it as Burberry's Blue and Black label! In 2015, the label re-branded to be called Crestbridge, after its parent brand Burberry decided to re-enter the Japanese market. Targeted at youths, the designs channel modern chic, but with a quirky twist.
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CINEMATIC PREPPY シネマティックプレッピー AUTUMN 2017は「CINEMATIC PREPPY」をテーマに、ヒロイン気分を楽しめるスタイリングを提案します。 50 ~ 60 年代の映画に登場する女優からインスピレーションを得たレトロフェミニンな女性らしさとブルーレーベルらしいキュートなプレッピーさをミックスさせたコレクションです。 #bluelabel #crestbridge #bluelabelcrestbridge #preppy #accessory #bag #dress #skirt #brouse #knit #fashion #autumn #styling #ブルーレーベル #クレストブリッジ #ブルーレーベールクレストブリッジ #ワンピース #スカート #アクセサリー #バッグ #ブラウス #ニット #レザー #三原康裕
#6 Pepsi Christmas Cola & Kit-Kat Birthstone Chocolates
Yup, you read right. Japan is the land of strange, quirky food, which is why popular confectionery brands love releasing limited-edition flavours there! This year end, you'll be able to get a Christmas cake-flavoured Pepsi drink, and a series of seasonal Kit-Kats. The Birth Stone chocolate collection follows (obviously) the monthly birth stones, with a new flavour released each month. December's is Tanzanite (purple yam).
[RELATED] Download the Airfrov App (Android/iOS) and use referral code CHANGI for $10 off your first purchase ($5 off $35 spend, or $10 off $70 spend).
#7 Street Fighter x Transformers Figurines
In a puzzling crossover, Japan sees their favourite arcade game heroes from the Street Fighter series as they turn into robots—transformers, to be exact! Scheduled to be released only in Japan in May 2018, these unique toys will come in the form of robot Ken, Ryu, Chun Li, and M. Bison/Vega.
Video credit to ガジェット通信(GETNEWSJP) via YouTube.
#8 Pokemon Center Merchandise
How can we miss this out? Fans of the yellow pocket mouse will know all too well that the best Pokemon merchandise can only be found in Japan! Head to the Pokemon Centers across Japan and pick up adorable souvenirs like plush toys, key chains, stationary, and many more.
Video credit to SuesKawaiiCollection via YouTube.
#9 Issey Miyake Limited Edition Bao Bao Bags
Now, you can snag the Bao Bao bags in Singapore, but did you know: The full range is in Japan! Considering it's a Japanese brand, this is not surprising. There are many limited edition colours and designs that can only be found in Japan; plus, and they're about 30% cheaper!
Check out Nationwide JR Pass Cheat Sheet: Top Destinations & their Stations, 15 Japanese Snacks You Will Regret Not Buying Home, and 48h in Tokyo: Free Things to Do in the City!
Ready to embark on your adventure?
Reserve your ChangiWiFi router for UNLIMITED internet 24-7, at as low as $5/day*. Beat the queue and book those attraction tickets and day tours with us—no frills, no fuss.


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Natural coloured diamonds of the same colour grade can look quite different. This is very important to know when considering your purchase. Diamonds graded "Fancy Intense Pink" for example, are often different colours. This is why we say that every natural coloured diamond is unique and part of what makes them so remarkable. Therefore, viewing the diamond/s before purchasing is recommended, so that the beauty and value may be more accurately judged.
Collector's Edition
Size:4=0.11ct round brilliant cut
IGI colour: Natural Fancy Intense Pink / Greyish Blue
Origin: Argyle-Type 1a
IGI certificate number: 361969165
Argyle colour:4PP/ BL2
Price: $12,000
** Actual colour may vary.
For more information, please call our QVB store +61 (0)2 9267 7974.Enquire Now »


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2019! Sixth 6th Day of Navratri Maa Katyayani Colors Sms Wishes Whatsapp Status Dp Images :- Divine Goddess Katyayani is the 6th sign of Durga and one of the conspicuous gods among Navdurga. She is remarkably Worshiped on the 6th day of Navratri pooja. Her appearance is tremendously glorious and divine. She is spoken to with four arms. Her upper left-hand holds sword and lower left hand to speak to lotus-bloom. Her upper right hand is in Abhayamudra, and lower right hand is in Barmudra. Lion is her parade. Her appearance is envisioned with pink Saree wearing white rosary on her neck. Goddess Katyayani likewise speaks to celestial force for wrecking oppression and torments of evil spirits and goliaths. Venerating this Goddess on the 6th day of Navratri Puja gives coveted spouse and achieves other genuine wishes. Admirers and Sadhak enter in 'Agya Chakra' venerating Goddess Katyayani on the 6th day of Navratri Pooja. Her magnificence is vast. She is exceedingly liberal toward her admirers and fans. Happy Sharad Navratri Wishes SMS FB Whatsapp Status Images
Maa Katyayani has 3 eyes and 4 hands. She holds a sword in Her one cleared out a hand and a lotus in another. The other 2 hands individually demonstrate ensuring and permitting activities. In the event that you make the promise of fasting and revering her, she would favor you with the spouse you have wished and petitioned God for. On the off chance that a woman's marriage is getting postponed because of either reason, she may love Maa Katyayani to expel hindrances that might bring about deferrals in her marriage. Best Navratri Sms Wishes Quotes Fb Status Whatsapp Messages
- 6th Day of Navratri Colors 2019: Green
Chant this mantra to worship Goddess Katyayani…
नन्द गोपसुतं देविपतिं मे कुरु ते नमः ॥Kātyāyani mahāmāyē mahāyōgin'yadhīśvari |
Nanda gōpasutaṁ dēvipatiṁ mē kuru tē namaḥ ||
Navratri 6th Day Sms Wishes Images
Duao me shamil ho is tarah,
fulo me hoti hai khushbu jis tarah,
MATA aapki zindagi me khushiya de is tarah..
dharti par hoti hai Barish jis tarah.
Abhi domino's pizza se call aayi thi
ki aap bahut dino se aaye nahi..
Saalon ko bahut sunaya..
Haramkhoro ne poori navrartri..
ek se ek pizza ki photo bheji mail box me..!!
What is that bright light?
from where does this fragrance coming?
This gentle breeze..cool air..hearty music..
oh! its Navaratri Happy Navaratri.
Navraat hai puja sankalp ki,
Atma-Shakti ki,
Kabhi na Haar manane wali Pravarti ki,
Nirasha me asha ki kiran ki..
Apnakar Navraat ko safal banaye,
Wish you Happy Navratri.
Nile Rang Se Saja Maa Ka Darbaar,
Harshit hua man, Pulkit hua Sansar,
Nanhe Do Kadmo se Maa Aaye aapke Dwar..
Mubarak Ho Aapko Navratri ka Tyohar.
Chand ki chandani, Basant ki bahar,
Phoolo ki khushbu, Apno ka pyar,
Mubarak ho aapko NAVRATRI ka Tyohar,
Sada khush rahe aap aur apka Parivar.
May the festival of lights be the
harbinger of joy and prosperity.
As the holy occasion of Navratri is here
and the atmosphere is filled with the spirit of mirth and love.
Hey! Maa ambe apne bhakto par apna hath rakhana,
NAVARATRA ke subha din par hum sub apki sharno me rahe or
is 9 dino tak apki seva puja or bhakti kare.
Memories of moments celebrated together
Moments that have been attached in my heart forever
Make me Miss You even more this Navratri.
Hope this Navratri brings in Good Fortune.
Dekh News Team wish you & your family Happy Navratri. ?


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For Amazon Prime lovers, the service has become an indispensible part of their online experience. Between speedy delivery and a vast catalog of movies and shows, Amazon users are increasingly buying into Prime status to...Read More →
When it comes to electronics like phones, laptops, computers, video games, tablets and other mobile devices, cost and quality are crucial factors. If you can't afford to pay full price for a brand new MacBook,...Read More →
If you're like most Americans, you may still be coming down from the holiday high that happened last week. No, we're not talking about Thanksgiving, we're talking about the modern shoppers' holiday: Cyber Monday. Though...Read More →
Internet shopping has been increasing in popularity for the past decade, but with the rise of the smartphones and other mobile devices, more and more shopping is being done on the go with the swipe...Read More →
In this digital age, more and more kids are glued to their smartphones. The Internet is a big world and there are many things not suitable for young children. At least 77 percent of parents...Read More →
Are you looking for a way to show your dad how much you love and appreciate him on Father's Day? If you're feeling generous this year, you can't go wrong with an iPad tablet. Sleek,...Read More →
We've all heard the stories about entrepreneurs who came up with a great idea and cashed in big time after taking the startup public. Apple, Amazon, Google and Facebook are just some of today's corporate...Read More →
It seems like no one is stoked about the new Redbox Instant. In late March, the kiosk-based DVD-rental service that essentially killed Blockbuster with their 99-cent rentals rolled out their online video service to Xbox...Read More →


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My Trip To Las Vegas
This was one of the highlights of my trip to the CES conference in Las Vegas January 2006. I was able to go on the Star Trek experience at the Hilton Hotel in downtown Las Vegas. We were attacked by the Borg and captain Janeway from the starship Voyager came toour rescue. We were also kidnapped by the Klingons and that was a wild and fun ride.


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White House hopeful Ben Carson dropped out of Thursday's GOP debate and signaled that he is unlikely to remain in the Republican presidential fight much longer.
"I do not see a political path forward in light of last evening's Super Tuesday primary results," the one-time tea party favorite said in a statement after logging another series of near-last place finishes. "However, this grassroots movement on behalf of 'We the People' will continue."


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Friday, June 16, 2006
The Drawing Hand
"The Drawing Hand"
March 1999
"The difference seems to lie mainly in the function which doodling has in the lives of the untrained normal and abnormal individuals.While doodles may occupy a significant part in the life of the mentally ill, they are incidental products of the normal. Occasional observations of untrained normal individuals, as well as self-observations, suggest that doodling tends to occur while one is either "unoccuoied" or in a state of distracted attention, i.e., when the ego is fully occupied with something else. At first one is frequently aware of a certain purposive idea, an "intention to draw", which may refer to any geometrical or decorative design. In some instances, one may "intend" to reproduce some object in the environment; in others, there is no such intention. In the course of doodling this intention gets lost. The drawing hand "creates" autonomously; lines or steps "suggest" subsequent ones. Clinical Observations suggest that doodling has a frequent if not regular dynamic function for the normal: Fantasies and thoughts hidden in doodles are those of which the doodler wants to liberate himself, lest they disturb the process of concentration. While there are cases in which the function of doodling is similar for psychotics, in mant, and probably in most, instances its function is quite different. The doodle tends to be taken "seriously"; it may becomes a highly invested product.
-Unknown sourse
Wednesday, June 14, 2006
Today Is Today
Monday, June 12, 2006
One Giant Step Back
"One Giant Step Back"
May 2006
"Life became less easy for me: When the body is sad the heart languishes. It seemed to me that I was half unlearned what I had never learned and yet knew so well- how to live. I think it was probably then that everything began."
Albert Camus "The Fall" 1957
Friday, June 09, 2006
You Ruined Everything
Thursday, June 08, 2006
November 2000
The ultimate in self destruction.
I have a huge fear of getting my right hand cut off.
Tuesday, June 06, 2006
Stool Softener
Friday, June 02, 2006
Must Be Destroyed
"Must Be Destroyed"
June 2001
Three words.
Destructive, angry, and afraid.
Deceitful light without bright colors.
Almost fighting to not be drab, boring, and forgotten.
Nothing left. Must be destroyed.


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Join us at Hubbell & Hudson Bistro on May 17 to learn how you can go on a culinary adventure with Executive Chef Austin Simmons to the Riviera Maya this fall for the Lone Star Food Art & Music Festival.
Meet and mingle as Chef Austin prepares complimentary hors d'oeuvres paired with Jackson Family Wines to show you what your tastebuds can expect during this getaway opportunity. Representatives from 2 Getaway Travel will be on site to share more information.
The Riviera Maya is an ideal vacation destination extending along the Caribbean coast of Mexico's Yucatan Peninsula. Its coastline is a modern tourist corridor, offering high-end luxury resorts, fine dining, spa retreats and some of the most beautiful beaches in all of Mexico.
To RSVP, please click here.


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Philippines economy is set to remain on high levels this year. The growth of Philippines is due to stable large consumer population. Private building construction is seen to maintain its growth momentum, with a projected growth of 17% this year (based on approved building permits), which indicates extra cash from the pockets of the consumer and openness of bank credits. The additional push would be coming from the government construction projects – when and how this project will be executed remains the question and would be a big factor in the economic growth.
While Overseas Filipino Workers (OFW) is seen to slow due to slowdown in global economy, remittances remain stable which is projected to grow by 5.54% this year. The game changer in the Philippines economy would be how to financially include the poor in economic growth, which is majority of the population. One of the main solutions remains the creation of jobs that does not require high educational skills. Even the new graduates of universities are having difficulty of landing a job, how much more to those who are not educated. Another solution is to encourage the youth to create start-up businesses with the help of government and private institutions by providing seed funds, incubations, and right information. Moreover, the development of agriculture sector – which is one of the core strengths of the country – could pave way to higher growth level.
On other hand, energy supply and cost remains blurred and could significantly affect growth negatively if not given a focus. There are some utilities (renewable and non-renewable energy) projects being constructed in the country, but the impact has not been felt.
Based on Philippine Economist Database, Philippines Gross Domestic Product (GDP) growth this year 2015 is projected to remain on high levels at 7.05%. Q1, Q2, Q3, and Q4 2015 growth is projected to hit 7.19%, 6.59%, 7.68%, and 6.80% respectively.


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Boxing Day Lunch Sandbanks
Sandbanks Vale do Lobo would like to invite you to the Boxing Day Lunch on 26th December! Extend your Christmas celebrations with delicious meal, with the most amazing Ocean view. From 2.30pm relax and enjoy Live Music from our resident band. Book your table today and be guaranteed a great festive atmosphere! Open from 12.00pm with a fantastic selection of seafood and salads from our extensive menu.
Great wines, great beer and a great atmosphere are guaranteed. Relax after all the stress of xmas and let us do the work!! What better way to spend Boxing day. We are hoping for great weather but never the less with our new indoor closed restaurant come rain or shine we can assure you will be well looked after.
tables are being booked up fast, so dont be disappointed and book your table now…For the Reservations Tel: 289 398 429 or visit the reservations page.


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Hello, I hope everyone had a good Easter. I just want to let you know that Kinnikinnick has delicious blueberry donuts for sale right now. If you are a donut lover, and who isn't, these are the perfect little breakfast treat. Enjoy!!! Full disclosure; I received a free package of blueberry donuts to try from Kinnikinnick.
Week 4 Healthy Meal Plan
3 hours ago


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Summary of updated findings
AECI is to be commended for disclosing the following environmental compliance monitoring and enforcement activity in its 2015 Annual Report:
On 14 December 2015 the Department of Environmental Affairs ("DEA"), accompanied by representatives from the City of Johannesburg, conducted a search and seizure operation at AEL Modderfontein. Subsequent to this AEL was advised by the authorities that consideration of its postponement application will take place after the issues raised as a result of the search and seizure operation have been resolved satisfactorily. Management is cooperating with the DEA and has submitted a response to its allegations, relating to AEL's compliance with certain conditions of its current emissions licence. Feedback from the DEA's process is awaited.1
Considering the seriousness of the above, however, AECI should have disclosed details of the allegations relating to AEL Mining's compliance with its emissions licence, as well as details of the company's response to these allegations.
- AECI 2015 Annual Report, at p68.


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People often ask me which companies I think have done a good job at branding, and about those that have gone a step further and created a paradigm shift in their industry. Going outside of my usual realm of examples of online companies, I love to talk about Icebreaker as a great example of this. Icebreaker is a New Zealand-based company that makes edgy outdoor clothing from high quality wool called Merino. It is an amazing business story and great case study of how to create a premium brand through an innovative approach to marketing and new thinking.
15 years ago when I left New Zealand to move to the US, wool products were hokey and old fashioned. People wore sweaters to keep warm, but they definitely weren't stylish. Wool is big business in New Zealand and when I grew up most was used in carpets, sheepskins and other products. NZ wool was certainly a good product by global standards, and there was plenty of it, with upwards of 60 million sheep in the small country.
Then, in 1994, a company called Icebreaker was born. In 16 years, they have transformed the way people think about wool clothing, built a partnerships with farmers that embrace their sustainable philosophy in order to get the best quality wool and, at the same time created a global market for their products. Talk about a paradigm shift.
Today, Icebreaker is sold in 2,000 stores in 37 countries throughout Europe, Asia, New Zealand, Australia and North America.
So how did Icebreaker do it?
Inspired by the place where the wool comes from (the rugged and dramatic high country in NZ's Southern Alps) they have made the origins of the product, and nature the centerpoint of their business. Sustainability is deeply entrenched into every part of the process and the marketing of the products. Linkages to where the materials came from are so important and highlight the authenticity of the product.
- Investment in design: By designing apparel in new ways that wool hadn't been seen before, Icebreaker created a demand for a product that didn't exist before and allowed them to tap into a completely new, and global marketplace.
- Making wool sexy: Their designs make people feel differently about themselves – they are very flattering or complementary to the body, and they feel good on. Rebranding wool clothing in such a way that makes it sexy and appealing – who would have thought wool could be?
- A clever branding and marketing campaign: Highlights the origins of the fibre and recognizes the unique natural environment that enables this product to grow, as well as communicates the outdoorsy, rugged sophistication of the terrain the sheep live in that is so unique. The marketing campaign tells stories in a dramatic and powerful way about where the fiber comes from.
- Transparency all along the supply chain: They have clearly outlined their business practices from the grower to the end user. By creating a "BAA code" for every product, consumers can now trace their Icebreaker gear back to the exact part of New Zealand where the sheep live. This highlights the authenticity of the product and reinforces that it is natural.
- Healthy obsession with quality: CEO & Founder Jeremy Moon says they have even had to turn down large chains in the US because he wanted to do it at the right time when the strategy was built. He believes it is a mistake to try to scale a brand too quickly and either "not be ready for it and disappoint people, or burn the people who are the core partners". Quality follows this product all the way through from where it is grown, the treatment and manufacturing of the wool to the store experience is seamless.
- A sustainable supply chain: Embracing and leading the way to sustainable practices through relationships with sheep farmers that produce the wool. They have created long term relationships with 140 high country farmers that last several years in order to ensure sustainable prices and help them become profitable. In return, growers give Icebreaker guarantees on animal welfare, environmental sustainability, guarantees on quality and supply. All members of their eco-system (growers and manufacturing plants) must share Icebreaker's core values around sustainability. This is a brilliant example of a brand taking care of its supply chain and fostering long term and trusted relationships.
- A vision to the future: They are prepared to challenge the norm and find innovative ways through design and manufacturing to create a superior product that goes well beyond what others do.
Icebreaker opened their US Flagship store this month at 102 Wooster Street, Soho, NYC. Go and check it out!
Which companies do you think are good examples of shifting a paradigm? Post your thoughts below.