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I'm traveling for work, standing outside the plane, when the flight attendant breaks the news that I'll have to check my carry-on bag. They insist everything will be fine; I'll get it back when I land. But on this particular day, on this particular flight, I have a bad feeling.
I hand over my bag. And when I retrieve it hours later, I find that it's no longer in one piece. The bigger problem? It's not even my bag. It's a priceless prototype on loan from Bugaboo.
The company famous for posh, rugged, $1,000 strollers stolen outside espresso shops is entering the $30 billion global luggage market. The Bugaboo Boxer is a modular luggage system that's designed to keep all your bags in one place. And at $1,500 for the entire system, it isn't cheap. I recently traveled for work with a top secret prototype, its logos covered in black tape, a precaution that seemed silly until, pushing the Boxer through O'Hare, I realized that fellow travelers checked out one another's luggage like dudes check out one another's cars–or more aptly, like parents check out other parent's strollers.
At its core, everything in the Boxer system sits atop a $630 luggage cart. It has a telescoping arm and four wheels that hook directly into the frame of one of two bags–a glossy polycarbonate black bag ($540) that's small enough to carry on a plane like a roller bag or a glossy polycarbonate white bag ($460), oversized for longer trips. If you connected the cart into the white bag, you can actually then slide the black bag to hook into the front of the white one.
When you press a button on the telescoping handle, and telescope the handle out to walking position, four wheels suddenly kick out from the base of your bag. They store inside the frame kind of like a turtle for durability and easy storage, and in a satisfying bit of mechanics, the bag goes from protected to ready to roll. But here's the kicker: You don't pull this bag, as you do most. You push it through the airport–yes, in a sensation that feels just like pushing a stroller.
"The most important thing that we've learned from strollers is the power of push," says Bugaboo founder Max Barenbrug. Pulling a bag puts your wrist and arm into an uncomfortable position rotation. Add weight, and this only gets more uncomfortable in pain that can reach into your shoulder. "To push is a lot different from pulling."
I didn't believe him on the phone. Pushing luggage? I'd seen the four-wheel roller bags and they looked as awkward as the two. But flying through multiple airports with the Bugaboo, I'm a convert. The ergonomics fit my body comfortably–just like a fancy stroller!–and the luggage rolls with an impossible smoothness. (In fact, if it's sitting by your side, the luggage doubles as a level. On any uneven surface, it will begin to roll away without you.)
As Barenbrug explains, this chassis isn't just key to the Bugaboo's design. It's also the core of the company's business plan. The aluminum chassis is the only component Bugaboo makes in-house under strict quality control. The Boxer bags may be Bugaboo-branded, but they can be developed with partners under less oversight–and with all sorts of different sizes, colors, and fabrics, too.
"[Now] if a consumer is buying an expensive suitcase, and they find the standards of the airline have changed, their purchase of this expensive case is fully a waste," says Barenbrug. "With Bugaboo, it's not. You buy this different sized, relatively cheaper suitcase that connects to your chassis and you continue to use it."
It's an argument that almost makes sense–except consumers don't see the wheels of their bag, and the bag of their bag, as separate line items when buying luggage. At least not yet.
Furthermore, all of this pushing comes at a price. Especially when it's combined with the Boxer's other design innovations, which are smaller, and many of which have been born from market research.
Inside the Boxer's carry-on roller bag is another bag! It's a soft lining case that unzips and lets you essentially double your storage on a long trip, for dirty clothes, souvenirs, whatever. It's two bags in one! Unfortunately, this lining takes up a lot of space. I had to remove it to have the room I needed for a short trip.
The Boxer also features this other, uh, thing. It's like a neoprene Trapper Keeper that you can stick onto the telescoping part of the frame. Ideally, it's a bug-out bag for sitting down on a plane, allowing you to snap it off to take a few magazines, and maybe a small laptop, to your seat. Again, it fits in with an impressive mechanics that I have no idea how Bugaboo engineered. Yet in practice, it's just another component to an increasingly complicated system. It's another piece that adds weight and seems all-too-possible to lose.
The project has been in development since 2007, during which time Bugaboo sent scouts to airports in New York and Tokyo, watching pain points. "It's scavenger hunts," Barenbrug says. "Just observing what's going on in airports and railway stations to see what people do, where we might find a solution to all the problems we see that consumers themselves don't address."
Yet over time, I can't help but wonder if Bugaboo tried to solve too many small problems to differentiate itself in the market.
Because solving all of these small problems lead to the Boxer's biggest problem: that it's really quite small. The core black carry-on, at least. As I power pack for my trip, I realize there's a lot less room than I'm accustomed to in my own bag. I suspect it's a result of the frame folding itself into the bag, along with another idea that sounded great on paper, but is functionally problematic.
The small roller bag is also quite heavy. At least 50% heavier than my normal bag, maybe more. That's because of the extra bag inside, along with that stroller-quality cart (which probably makes up its weight when you start stacking bags onto the system).
I quickly developed a love-hate relationship with the Boxer. Love: it rolls so well. Hate: it banged my shin again somehow and fuuuuuu it hurts. Love: it's so balanced I can just set my messenger bag on top and it won't fall. Hate: the catch about pushing your luggage is that it's very easy to hit people. Love: the effect of the pop-out wheels. Hate: sometimes two pop out, sometimes four. I could never figure out why. And getting them back inside takes some serious muscle that I always need to exert at inopportune times, like standing in the tight aisle of a plane.
While it's just a hunch, I suspect that it was the frame that got the best of the baggage handler that day. Remember, dear reader? That tale of me handing off the Boxer to the nearest attendant? When I'd get it back, I'd see that the telescoping frame was missing.
How did it pop off? Did some airport moving machine hit its release mechanism? Maybe. And that would be a pretty big design flaw. Or did some baggage handler get furious when they couldn't figure out how to get the wheels to pop back in, and rip the thing off? Maybe. And that would be a pretty big design flaw, too.
The Bugaboo Boxer is, in essence, a bit too clever for its own good. And as a result, its users may sometimes be prone to tantrums.
[All Images: via Bugaboo]


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Facilities and Services
Our serviced apartments are well-maintained and looked after making them a good, clean and safe place to stay in Wick during a short or long stay. Each apartment is fully furnished and equipped with everything you would need whilst away from home and you'll get more space, privacy and flexibility than alternative hotel options. We provide tea, coffee and milk as standard but will happily stock your fridge with provisions for a full Scottish breakfast or a romantic hamper for that special occasion or just simply some freshly ground coffee for the cafetiere, at a small extra cost. Just ask when you book.
What's included?
Apartments feature:
Well-appointed kitchen with all amenities
Radio or CD Player with iPod docks
Free WiFi internet access
Flat screen TVs with Freeview
Open-plan living room and dining area
Bathrooms walk in shower
DVD players
1 clean per week
If there's anything else you need that would make your stay more comfortable, we will happily arrange it for you but extra items will be chargeable.
Book with us direct for guaranteed best prices …
Please get in contact for more details.

subset: commoncrawl


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A dunce is a person considered incapable of learning. The word is derived from the name of the Scholastic theologian and philosopher John Duns Scotus, also referred to as Doctor Subtillis, or "Subtle Doctor", whose works on logic, theology and philosophy were accepted textbooks in the universities from the fourteenth century.
Duns or Dunsman was a name applied to the followers of John Duns Scotus, who were also called the Scotists. When in the sixteenth century the Scotists argued against Renaissance humanism, the term duns or dunce became, in the mouths of the Protestants, a term of abuse and a synonym for one incapable of scholarship. This was the etymology given by Richard Stinhurst. Samuel Johnson, on the other hand, maintained that the source of the word was unknown.
Dunces are often comedically shown wearing paper cone hats, known as dunce caps with the word "dunce" or "dumb", or simply a capitalized "D" on them. Schoolchildren were sometimes compelled to wear a dunce cap and to sit on a stool in the corner as a form of humiliating punishment for misbehaving or for failing to demonstrate that they had properly performed their studies.
The word "dunce" comes from John Duns Scotus (c. 1266–1308), the Scottish Franciscan scholar who, with Thomas Aquinas and William of Ockham, was one of the leading Scholastic philosopher-theologians of the High Middle Ages. Duns Scotus wrote treatises on theology, grammar, logic and metaphysics which were widely influential throughout Western Europe, earning Duns the papal accolade Doctor Subtilis (Subtle Teacher). (Duns remains highly esteemed in the Roman Catholic Church, and was beatified by Pope John Paul II in 1993.) However, with the advent of the Renaissance and the New Learning, and then the Protestant Reformation, many of Duns's theories and methods (which were considered hair-splitting) were challenged or rejected by Humanist and Protestant scholars, who used the term "Dunsman" or "Dunce" in a pejorative sense to denote those who foolishly clung on to outmoded doctrine. (The form "Dunce" reflects the medieval pronunciation of "Duns".) Gradually "dunsman" or "dunce" was used more widely for anyone stupid or dull-witted.
A dunce cap, also variously known as a dunce hat, dunce's cap or dunce's hat, is a pointed hat, formerly used as an article of discipline in schools. In popular culture, it is typically made of paper and often marked with a D or the word "dunce", and given to unruly schoolchildren to wear. Frequently the 'dunce' was made to stand in the corner, facing the wall. The hope was that no one would want to be labelled the "dunce" in the class, even for a short period of time, and would thus avoid misbehaviour. Examples of behaviour which could warrant the dunce cap included throwing spitballs, passing notes, or pulling of hair. Class clowns were frequently admonished with the dunce cap.
In modern pedagogy, dunce caps are extremely rare.
According to The Straight Dope, Duns Scotus recommended the wearing of conical hats to stimulate the brain – so-called "thinking caps". (This notion is the likely source of the pointed hats traditionally worn by wizards, etc..) However, the Oxford English Dictionary (2nd edition) records that the term "dunce cap" itself did not enter the English language until after the term "dunce" had become a synonym for "fool" or "dimwit". In fact, "dunce cap" is not recorded before the 1840 novel The Old Curiosity Shop by Charles Dickens. John Ford's 1624 play The Sun's Darling is the first recorded mention of the related term "dunce table," a table provided for duller or poorer students.
A literary dunce is a person, either real or fictional, who is used in literature as a target of satire. This usage of the term derives from Alexander Pope's landmark poetic satire The Dunciad, and the list is for figures used as dunces by eighteenth-century British satire (in the standard literary-historical sense of the "long" eighteenth century, 1660–1800).
It is also for early nineteenth-century authors who used the same general terminology (e.g., Lord Byron and Samuel Taylor Coleridge who knew and used Pope's category). Dunces are not villains, although they can be villainous, as much as they are held up as the epitome of stupidity, imposture, and connivance. Inclusion in the list below does not imply that the figure was a dullard. In fact, the opposite is likely true, as these figures needed to rise to a position of importance to be satirized in this way. Instead, these are figures who were satirized particularly as symbols of all things "wrong" with society or a particular political position. Unfortunately, in some cases it has overshadowed their merits.


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- Greater London
- £35,000 to £40,000
- Permanent
Clinical Services Manager – Outpatients, Hendon, Full-Time, £35,000pa – £40,000pa + Benefits
I am currently looking to recruit an experienced Clinical Service Manager to work within the Outpatients department of a private clinic in Hendon. This role is being offered by Britain's leading independent healthcare provider, consisting of a network of hospitals and clinics which perform more complex surgeries than any other private healthcare provider.
The successful candidate will be suitably qualified to have achieved NMC registration and have at least three years post-registration experience within a clinical environment, and previous experience within a Clinical Lead role.
Key requirements for the role:
* NMC registration
* 3+ years relevant post-registration experience
* Good interpersonal and communication skills
* Ability to lead a clinical team.
* Excellent organisation and multi-tasking skills
* Strong ability to make judgements involving complex information or situations which require the analysis, interpretation and comparison of a range of options.
The successful candidate will not only receive a competitive salary, benefits include 25 days paid annual leave + bank holidays, private medical insurance, life assurance, childcare vouchers, bi-annual health screening and more.
This is a full-time position, 37.5 hours per week.
Salary range of £35,000pa – £40,000pa.
Employee benefits include:
* Competitive salary
* 25 days paid annual leave + bank holidays
* Flexible Working 08:00-20:00 Monday – Saturday
* Private medical insurance
* Life assurance
* Childcare vouchers
* Bi-annual health screening and more.
For further details regarding this opportunity please contact Grant Richardson at Medicor on 023 9232 2366 or email your CV to firstname.lastname@example.com
STR Limited is acting as an Employment Agency in relation to this vacancy.


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Write your way of life tale straight down. It doesn't must be a significant novel, but make some account in your life which means that your kids or grand kids can get acquainted with everything you've observed and been through throughout your daily life. No kids? Do it for relatives or good friends.
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Recall, you are only as outdated while you truly feel. By trying to remain lively and carry on carrying out those ideas you loved when you were younger, you are going to actually remain healthier and more suit than if you sit down around. Don't work like a teenager, but do still be involved in volunteer activities and athletics that you simply appreciate.
If you have any thoughts concerning wherever and how to use חיזוק הפין - http://maxsize.info , you can contact us at the internet site. Getting your blood pressure levels inspected consistently is a need to dwelling longer and maintaining healthful. Many people are unaware of their high blood pressure, however it is actually a considerable risk element in stroke, coronary disease, and renal system disease. Should you be identified to obtain elevated blood pressure consider your medicines that happen to be approved physical exercise, quit smoking, and look after appropriate body mass to lessen your hazards.
Consume healthy and healthy foods simply because this will go a long way both in the way you look and how your whole body executes since it grows older on the inside. When you eat the proper food items, it is possible to support avoid a number of illnesses and setbacks inside your body. Have a healthy way of life nowadays.
Consuming organic and natural foods can considerably reduce irritability troubles as a result of foods ingestion. These food types have less chemicals and the like to them, which enables you to be eating organic and natural food products. This will eliminate significantly epidermis irritability from eating those other food products, and it will surely aid you in your process of aging.
A wonderful gift mature young children may give is tending to growing older mothers and fathers! To accomplish this, there are many facts to consider. In the region of finance, it is essential to produce a finances specifically for proper care offering. Compose a list of the things funds you must deal with, and the requirements you parents. This should help you determine if cash are being utilized to their highest potential!
Ageing is all about more than a bad affect on your skin's appearance. Lots of people consider it can be sorted out with basic lotions and fats, but that is insufficient to drill down in and fight some of the real signs and symptoms that aging results in. The advice given in this article does just that and really should be implemented in a fashion that positive aspects you.


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Efficient Ticketing Turns Customer Service into Customer SatisfactionPosted by david.jensen Oct 8, 2014
The need and quality of your product brings your customers through the door, but it's your customer service that keeps them coming back. Your customers' experience with your post-transaction service and support is a big contributor to your organization's ability to gain customer confidence and loyalty.
Ideally, you want customers to use your products without needing technical assistance. But, with technology products, customer support calls are inevitable. Your value as a company is determined by your customers and their encounters with your organization. This means your customer support methods need to proactively accommodate your customers' needs and timelines.
Often, customers needing technical assistance are in a time crunch so speedy resolutions are always desirable. So, what can you do on your end to avoid service delays, reduce customers' wait time, and ensure that customer interactions are positive? Improving performance and productivity starts with organizing your workspace. With the right tools and staff, you can deliver a high standard of customer service that results in high customer satisfaction.
Automation to the Rescue
You likely get the customer-support ball rolling by creating a ticket after the initial service request (i.e. email, phone call, text message). Then there's triage, routing, escalating, assigning a technician, and notifying the customer that a ticket is created and a resolution is in the works. Where customer service is all about efficiency and quick turn-around times, automating as many of these tasks as you can significantly accelerates these processes and keeps you organized.
Your help desk is staffed with a group of hand-picked, talented technicians with particular skills sets and specialties. This is always useful for the many times you need to re-route or escalate tickets. Your help desk tool also brings a cache of talents to the table. It's worth your time to configure your help desk tool to recognize the specialties of individual technicians, groups of staff, ticket categories, and priority levels. This cuts down on much of the effort in manually expediting tickets.
Where the Customer Service Rubber Meets the Road
Raise your hand if you've ever had a customer call to check the status of an issue. It's understandable that people don't like to wait. Drumming fingers on the desk gets old pretty fast. But what's worse than waiting is not knowing how long the wait will be.
Give your customers the benefit of the human touch by keeping them informed throughout the ticketing process. Over communicating is not annoying when it's for the benefit of the customer. The majority of positive customer service stories include a testimonial about how he or she was kept in the loop every step of the way.
When you close tickets, make it easy for your customers to give you some feedback and lend their opinions about their customer service experience. Again, this is where your automated help desk processes give you the luxury of effectively interacting and building a rapport with your customers to assure them that their needs are important to you.
The customer relationship is the heart of any business. When a high level of customer satisfaction is your goal, your help desk ticketing processes is how you achieve most of your customer-centric milestones for that goal.


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I had some notes that I sold over the phone.The client said this Would you be interest in selling your note to me, if so I'm interested in buying.I have cash.They will give you a yes or no answer.Keep it simple
LoopNet Answers is where the commercial real estate community shares what they know to help each other out. And it's all for free.
Ask a question to get advice from brokers, investors, professionals and local experts.
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Lehigh Valley Transportation
Lehigh Valley Transportation
Highways and Bridges
It takes Lehigh Valley residents an average of 25 minutes to get to work. There is little recurring congestion outside of the morning and afternoon rush hours in the Lehigh Valley. Our regional transportation network is complete and functions reasonably well in terms of ease, safety and convenience. The key question is: can it be sustained? Without a significant increase in capital funding, the answer is no. The lack of needed investment will result in a decline in the performance of our roads and bridges, meaning longer travel times due to congestion and detours.
The focus over the last four years in the Lehigh Valley (and across Pennsylvania) has been on maintenance, in particular bridge maintenance. Even with the many bridges repaired over the last four years, the list of bridges across the region that still need to be rehabilitated or replaced is long. Each year additional bridges come on the list. Meanwhile, highway ride quality has deteriorated over that same time frame with the investment focus on bridges. Numerous reports at both the Federal and State level document that transportation funding is very inadequate; prospects for increased investment in the near future are not good. In fact, the lack of transportation funding has been the determining factor in many of the investment decisions made in the last five years. Consider:
The Lehigh Valley Transportation Study (LVTS)
long range plan
estimates a $1.7 billion shortfall for funding needed through 2030. The shortfall is 106% of the expected revenues over the same time frame.
The Lehigh Valley Planning Commission (LVPC) completed a study on Route 22 in 2001. The report recommended widening Route 22 to six or eight lanes, starting with the section from Airport Road to 15th Street. Due to a lack of funds, this project was scaled back to interchange improvements at MacArthur Road and Fullerton Avenue and replacing the bridge over the Lehigh River. While this may improve safety at the interchanges, the project will not address recurring congestion along this important employment corridor.
LVTS has identified the Route 22 corridor as its number one congestion priority. However, according to LVTS' long range transportation plan findings, widening of the most important section of Route 22 cannot be completed over the next 18 years due to lack of funding. Meanwhile, the other 12 corridors identified in the plan as needing attention to relieve congestion will not be addressed over that time frame, again due to lack of funding.
From 2006 through 2010, the Lehigh Valley had an average of 61 fatalities a year and 166 major injuries on its roadways. This average has been declining - 51 fatalities occurred in 2010 compared to 81 in 2005, a 37% reduction. However, many safety issues remain. Addressing these issues would surely result in fewer fatalities and injuries. Funding for safety improvements needs to be increased.
Given the condition of the highway and bridge network, maintenance must continue to be the focus of investment. Without an increase in financial resources, other important areas such as safety and congestion reduction will remain unaddressed. Minor improvements can be made with funding that is available such as cutting back trees to improve sight distance and synchronizing traffic signals to improve traffic flow, but this approach will not be an adequate substitute to the improvements needed to keep the Lehigh Valley highway network running smoothly.
Public Transportation
A key component to the future the Valley will be the level of access to alternative modes of transportation like public transit, walking and biking. Currently, we face two major challenges in terms of access to public transportation. The first is the overall level of public transportation service available to residents of the Lehigh Valley. To increase the overall level of public transit available LANta studied the idea of "bus rapid transit" for the Lehigh Valley. The second challenge to increased transit is that many areas of the Valley have not been developed in a manner that facilitates the use of transit.
For transit to be feasible, residents must be able to safely and conveniently access bus stops to board the bus as well as their final destination once leaving the bus. This requires a comprehensive and safe network of sidewalks, marked crosswalks and pedestrian phases at traffic signals. In addition, our neighborhoods, office parks and retail centers must be designed or retrofitted in a way to allow people to walk into, out of and throughout the developments in a safe and convenient manner. These types of improvements and changes to development patterns will happen when local municipalities create policy that fosters "transit oriented development".
LANta has completed a
Transit Oriented Development study
, which further defines how land development in the Lehigh Valley can be done in a way as to promote and facilitate the use of transit. While development in the downtowns of the three cities, and other traditional urban centers is preferred from the standpoint of transit provision, it should be noted that the Comprehensive Plan calls for urban development in currently un-developed or sparsely developed areas. It is critical that development which takes place in these areas be done in a way as not to preclude or discourage the use of transit in these areas. Accordingly, this document does direct significant focus to the type of development which will occur in the more suburban areas outside of the traditional urban core but that are still consistent with the regional Comprehensive Plan.
LANta conducted an enhanced bus rapid transit (BRT) system study that looks at making certain bus routes more efficient given the land use surrounding the identified routes. The
Enhanced Bus/Bus Rapid Transit Plan
, includes the preparation of a conceptual enhanced bus/bus rapid transit service plan, identification of regional goals and objectives for the service, analysis of demand and potential benefits within each corridor, identification of a "trunk" corridor or corridors, development of a conceptual design plan for the corridor(s), and a final implementation plan which together may be considered as an application to the FTA for the Very Small Starts program.
The following are the goals and objectives of enhanced bus service (EBS) in the Lehigh Valley, as determined by the study team with input from the LANta Board and the Study Advisory Committee. Input from the series of public meetings was also considered and incorporated. The broad program goals for the development of Enhanced Bus Service in the Lehigh Valley include:
Benefit current riders;
Expand the transit market – attract new and choice riders;
Promote revitalization of the Valley's urban core;
Maximize productivity (riders per hour); and
Be financially feasible.
Lehigh Valley Transportation
The Lehigh Valley Transportation Study (LVTS)
is the Metropolitan Planning Organization (MPO) for Lehigh and Northampton counties and it housed at the Lehigh Valley Planning Commission. The role of the MPO is to promote transportation projects, plans, programs, and policies that are consistent with the locally adopted Transportation Improvement Program (TIP) and Lehigh Valley Transportation Plan (LVTP). LVTS was created in 1964 through a legal agreement between the Cities of Allentown, Bethlehem, and Easton; the Counties of Lehigh and Northampton; and the Department of Highways of the Commonwealth of Pennsylvania (now the Pennsylvania Department of Transportation).
The LVTS was founded in response to the Federal-Aid Highway Act of 1962, which stated, in part, that any urban area with a population of more than 50,000 must maintain a continuing, comprehensive and cooperative transportation planning process in order to be eligible to receive Federal funds for transportation projects.
May 2014 Newsletter
May 2014 Newsletter
February 2014 Newsletter
February 2014 Newsletter
Renew Lehigh Valley Seeks Public Input on the Region's Future
Renew Lehigh Valley Seeks Public Input on the Region's Future
Coalition Asks People to Help Shape the Lehigh Valley's Future
Coalition Asks People to Help Shape the Lehigh Valley's Future
LVPC Regional Planning Dinner + Community Awards
Lehigh University, Iacocca Hall
Summit for Smart Growth and Sustainable Communities
Hotel Bethlehem
Sign up for our mailing list and we will keep you informed about how you can help change your community for the better!
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The Claritum system has been superb!


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Broome is a town located in Western Australia. For those who need to settle in this region, there are many home builders to choose from. Choosing the right home builder is vital since a home is an expensive investment. Broome home builders have different categories, depending on their line of qualifications. Some builders categories include unit builders, design and construction, custom home builders, small lot builders, colonial or timber home builders, display home builders, removable home builders, renovation builders, and unit or commercial builders. With such an expansive list, you need to consider several factors in choosing the right one. These are:
Personal preferences
When looking for perfect Broome home builders, it is important to know your personal preferences first. This will include making an informed choice on the exact kind of service you need. You can then search for builders offering services that are in line with your needs. Such an approach will reduce the time spent in search of a perfect builder.
Personal referrals, references, and online searches
When looking for a home builder in Broome, ask for references from homeowners who have had recent projects done. This will give you lead on the most preferred builder to hire. Additionally, analyzing homes similar to your project can help you have contacts with the right builder.
Online searches yield results to quality home builders in Broome. This is because most of the reputable companies are listed on sites like Master Builders Association, for easier access. Online sites allow you to conduct searches for builders by project location, project type or rating.
Gauging the status of Broome Home builders is important. This should be done by making a list of prospective builders. Checking out projects they have recently handled will give you an idea of their work credibility. In order to get the fact-based information, talk to people who have hired your prospective builders. Ask about the builders' client relation and service delivery, their ability to listen to the client's needs and act on them and their relationship to team members. This research will offer you feedback on the most credible builder to hire, with a better reputation.
Analyzing the services of a builder is an important task in choosing the right home builder. It is important to understand the type of services offered by any prospective Broome Builder. This can be done by interviewing the builder, reading informational materials provided by the building company and going to the firm's website. Most building and construction companies have websites and blogs offering information on their services. http://www.hmtracey.com.au/ is a site belonging to H&M Tracey Construction which is one of the credible Broome building companies. You may visit the site to learn more about what they offer.
Other services to check from prospective builders include warranties provided, future home maintenance, provision of information on appliances or safety gadgets installed, home care and handling of legal cases that may arise in the future.
Work quality
It is critical to analyze the work quality of a prospective builder. From sample projects they have implemented, ensure to examine their finishing, painting skills, installation of gadgets in the home for safety measures, cabinetry skills and the quality of products they use.


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Welcome to Chandler Lifestyle Magazine.
Started in 2013, this monthly publication was created exclusively for and about the residents of Chandler, Arizona.
Our mission for the magazine is simple– we hope to play a small role in helping the community flourish by producing a magazine filled with local news and interesting people, as well as special events that take place each and every month. We hope that you will 'run into someone you know' in each issue. Not only is Chandler Lifestyle exclusively for and about the residents, it is the pulse of what is happening and what is important to you.
Every month we will introduce you to a local family, business, restaurant and charitable organization. We'll spotlight outstanding students and teachers as well as civic leaders and volunteers.
This is your magazine Chandler so we encourage you to contact us with article recommendations. We would love to hear about your business, family or inspiring student.
We look forward to seeing you around town!


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Go Back
Go To Articles Directory Home Page
To get the current article, - See Below (at the bottom of the page) -.
For top news titles, see below.
Web sites and videos listed in this page are frequently updated.
If you find that this page is useful (quality of web sites, images and videos, ...), you can add it to your favorites.
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Really Cheap Auto Insurance - The Variables Behind The Rates
Really cheap auto insurance can be had as long as you, as an educated consumer, are equipped with the full range of facts and knowledge about how insurance companies come up with quotes for car insurance. Naturally, ones first inclination is to go online, access the sites offering automobile insurance, fill out the necessary form and then wait a moment a two for a quote. This is definitely the way to do but learning a bit about what the variables are that might make a different in price is well worth the time and effort it takes to do so.
About the Author: Dean Iggo is the webmaster of free insurance quotes advice website where you can quickly and easily find the best homeowners insurance quotes designed for you using our free hints, tips and resources.


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Hyperrealistic paintings of figures swimming underwater by Los Angeles-based artist Matt Story. His paintings uses gestures with water as a metaphor for self-reflection, birth, and cleansing. Story believes that his paintings represents more than a photographic image that captures a moment in time but that we filter our interpretation of art through our memories which reside as invisible imprints.
I try to paint contemporary life as to capture crystals of pristine memory that we all share but never describe to one another. Each composition uses the gesture of figure or setting to evoke a platonic form, an archetypal notion, a distilled essence, that thing that lasts beyond the moment.


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Historical literature is filled with the censorious proclamation to women… "you talk too much!"
From Ancient Roman times, to Shakespeare, to Jane Austen; literature is filled with references of women being talkative. These references are also contained in the contemporary journals and morality sermons of the day, such as The Spectator and Fordyce's Sermons, of which some excerpts are below.
We are told by some ancient Authors that Socrates was instructed in Eloquence by a Woman, whose Name, if I am not mistaken, was Aspasia. I have indeed very often looked upon that Art as the most proper for the Female Sex, and I think the Universities would do well to consider whether they should not fill the Rhetorick Chairs with She Professors.
It has been said in the Praise of some Men, that they could Talk whole Hours together upon any Thing; but it must be owned to the Honour of the other Sex, that there are many among them who can Talk whole Hours together upon Nothing. I have known a Woman branch out into a long Extempore Dissertation upon the Edging of a Petticoat, and chide her servant for breaking a China Cup, in all the Figures of Rhetorick.
The Spectator, No. 247, Dec 1711.
But what words can express the impertinence of a female tongue let loose into boundless loquacity? Nothing can be more stunning, except where a number of Fine Ladies open at once – Protect us, ye powers of gentleness and decorum, protect us from the disgust of such a scene – Ah! my dear hearers, if ye knew how terrible it appears to a male ear of the least delicacy, I think you would take care never to practise it.
For endless prattling, and loud discourse, no degree of capacity can atone. … How different from that playful spirit in conversation spoken of before; which, blended with good sense and kept within reasonable bounds, contributes, like the lighter and more careless touches in a picture, to give an air of ease and freedom to the whole!
Sermons to Young Women, James Fordyce (1766).
Whilst it is fascinating to hear the 'real' admonishments to the 'real' women in history, it is also interesting to look at the inadvertent reprisals to women that take place in literature. Rather than issuing a directive, literature uses the voice and experience of a character to convey the message of the author.
A few examples of talkative, 'out-there' women in English literature include:
- Beatrice – Much Ado About Nothing
- Kate – Taming of the Shrew
- Mrs Middleton – Sense and Sensibility
- Lydia Bennet – Pride and Prejudice
- Jo March – Little Women
- Anne Shirley – Anne of Green Gables
I had expected to find many negative portraits of women in literature; women who are chatty, vain, and frivolous, and indeed there are many. These women are the ones who gossip, slander, meddle, endlessly talk, are annoying, and have an unguarded manner.
What I did not expect to find was as many positive women as I did. These women are witty, playful, courageous, have educated opinions, and often express a sense of humour. In hearing the voices of these types of women through literature, it is evident that the authors have developed ways for the Fairer Sex to speak in socially accepted ways through the medium of their stories.
In essence, perhaps the lesson these various writers had for the women of their time is that it is not the talking in itself that is the problem. It is the effect is has on the people that listen. And I am sure that the issue has not changed through the passage of history… today our talking still affects those around us!
Who are your favourite female characters in literature? Are they the talkative, out-there kind?
Related Posts
What would You want in a Wife?
Sources and Relevant Links
Fordyce's Sermons to Young Women (1766)
"Women really DO talk more than men" – Daily Mail Article (2006)
"Talkative Women Myth Debunked" – NPR Article (2007)


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Hatchet is well known to locals but fairly obscure if you are not close by. It runs approximately 41 miles, northeast to southwest, originating near the town of Goodwater and terminating into Lake Mitchell. We ran the section from U.S.Hwy.231 (just north of Rockford) to Kelly's Crossroads. This is an all-day trip but may be broken into two roughly equal segments by using King's Bridge as a put-in/take-out. Hatchet is beautiful! The creek is narrow enough that the trees on the tall, sharply inclined, and rocky banks form a canopy over you for much of the trip but broad enough that you have room for maneuver. The bed is rocky and if you try a float with under a 300 cfs flow you will walk as much as ride. The only structures you will see are occasional cabins and a few bridges. Wildlife is abundant. Hatchet is a clean creek, being fed by springs and rainfall, and reacts quickly to rainfall; level and flow may go up dramatically in a very short time with heavy rain. We had two guys in a Mad River Teton and two in a Coleman and had a great trip. Sand bars abound at moderate to low flow rates and provide great places to take a paddling break. Many shoals but only one true rapid, a 1-2 depending on flow and an old, broken spill dam just below King's bridge that looks a bit hairy but actually is not.
Camping on the sandbars is fine. There is no outfitter so bring everything you need.
You may put-in at the bridge on U.S 280 about 15 miles north of Alexander City; put-in/take-out at U.S.231 bridge about 4 miles north of Rockford; take-out at Kelly's Crossroads bridge; all good facilities.


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Want to know what's happening around town? Click here to discover exciting things to do and places to go!
Tall Tree has a newly renovated fitness center and a very large Bark Park for our 4 legged friends! Pools are open as well.
Half off security deposit and admin fees for all military members with good credit!
Contact us for details!


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Jackie Devereux – "Much more sexy"
What you learn very quickly about Jackie Devereux is that everything she does is done with passion, enthusiasm, and a willingness and need to push herself to see how far she can go.
Born in London, it was while at school there that she fell in love with calligraphy. This and her love of drawing have shaped her as a person and an artist. After 2 years in 'a proper job' as an illustrator and graphic designer specializing in corporate logos and brochures Jackie enrolled at Art College in St Albans. It was a reminder that her love of drawing was her future path. Jackie then studied as a teacher and is qualified to teach adults and still does. Since 1981 she has been with Barry, a successful photographer in his own right and they have on occasion exhibited together. And there you have it, an artists life!
But that would be to do an injustice to this most approachable and giving artist. Jackie Devereux is known mainly as a watercolorist but she uses contemporary techniques and has for many years pushed the boundaries in this media with the use of bold transparent colors that previously were not associated with watercolors. She often incorporates calligraphy into her work and fine hand embossing.
She and Barry moved to France in 1991 and within mere months were running workshops sharing her knowledge and enthusiasm to an ever increasing audience.
She continues to run workshops and classes in both France and the US and is currently starting an art correspondence course to spread the word further. Her watercolors continue to push the 'normal' boundaries afforded to this media and she is currently producing large canvas watercolors as "a method to stretch myself, I now have the confidence to try this".
When asked to describe what it was she did, she didn't want to be held by the title "watercolorist" and her agent came up with the title of this piece which they both agreed was "Much more sexy"!
Looking at Jackies recent work you are drawn to the missing areas. The areas that she leaves white, ensuring that your focus is drawn to the composition of the work and this, like many areas of her work, may have been garnered from the graphic work she undertook in earlier years.
Jackie Devereux is equally at home with pen and ink and if you see her out and about you will no doubt spot her with a sketch book drawing with the unwanted gift of her Schaeffer pen. But look closely, Jackie Devereux does not replicate what she sees, she interprets and this is a gift that she passes onto others.
As has been seen, Jackie continues to look for ideas and new horizons wherever she goes and since a chance meeting in London, Jackie has been the artist in residence on a number of cruises for 5 years. Now firmly established after 14 cruises, she gives watercolor and drawing classes around the world. Add to this her weekly classes in the South of France and her workshops and holidays in the UK and at home in France and Jackie Devereux is an artist who not only stretches herself but wants to stretch others.
Jackie is working on large format works on paper and has now been for some time using an abstract based ideal. She states "I now have the confidence to try the large format works and as I tell people who come to draw and paint with me, it is never wrong to try something."
She has won numerous awards for her work and is a regular contributor to publications including 'The Artist'. She is a Council Member for the Society of Graphic Fine Art.
Jackie Devereux is widely collected and can be found in Private collections as well as hotels and corporate clients including B.P.
For further information visit: http://pagesperso-orange.fr/watercolour-online/


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available mid May
About This Grass
Soft spikey foliage that keeps its colour all year round makes Festuca glauca 'Elijah Blue' a top pick among the smaller grasses. It is a small, clumping grass with a rounded habit and remains evergreen all year. In early summer wheat-like seed heads are produced in great numbers on tall, spiky stalks. This grass prefers dryer conditions and will rot easily if soil is not well drained. This is the perfect grass for rock gardens, in stone troughs or pots or to use as edging. It has more impact when planted in groups of three or five. It requires a haircut in the spring and regular division to keep it looking neat. Some people find the seed heads attractive while others cut them down as soon as they appear to maintain the tight symmetry of the clumps
- Height: 20 - 30 cm (8-12 in)
- Spread: 25 - 30 cm (10-12 in)
- Cold Hardiness: zone 3
- Sun or Shade: Sun to light shade
- Bloom Time: Summer
- Leaf Colour: blue
- Bloom Colour: green with a purple tinge
- Critter Resistance: deer and rabbits
- Nature Attraction: none
Growing and Maintenance Tips
Grow Festuca 'Elijah Blue' in full sun and well drained soil. Winter wet will cause it to rot. Although it is evergreen trim it back in the spring to promote fresh new growth. Division every three to four years in the spring will keep the clumps looking good.


text: jonboyjon1990 870 Posted April 11, 2017 In multiple faction games I don't like to be stuck to just one faction - I always like to create at least two forces/decks/lists/armies/whatever, so that I can support a 2 player game, even if my opponent doesn't collect or play the system. I also don't like to 'pin my colors' onto any given faction, because what if they don't fit my playstyle eventually? So currently I'm aiming to make a decent force of all 4 factions. Is that totally unrealistic? I don't HAVE to have all the options for each faction - will probably aim for 300 points of each. I've got 2 cores preordered with my FLGS, so I'm ending up with around 100 minis and around 200 points per side. Buying x1 of every other expansion will give me around 300 points per side. I just wonder to what extent do people think we'll need multiples of any given expansion? Will I really ever need more than 3 rune golems for example? More than 3 cavalry units? 2 inaholeintheground and Dusty27 reacted to this Quote Share this post Link to post Share on other sites


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Exhibitor catalogue provides an overview of all the exhibitors at the fair.
Use the search box below for a specific exhibitor or a specific product.
You can also find exhibitors by product category or stand location.
The exhibitors present a host of news, products, competitions and offers. Click below to see the complete lists.


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The goal is that you would have effective conversations with anyone. Remember that the main thing is to aim for the heart and not at the person's intellect.
Our prayer is that you would become an excellent fisher of men and that God would show you his love for others in a deeper way. We trust that during this training period you would experience divine appointments and that you would dedicate your life to becoming a soul-winner.


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The best available unrestricted rate.
We go out of our way to make our youngest guests feel welcome. Our resourceful Concierge is always close at hand – to make reservations for a family dinner, offer suggestions for tomorrow's family outing or help arrange a babysitter during your family vacation or getaway.
From zip lining and tubing to sleigh rides and skating, we've got all the activities you need to turn the great outdoors into your family's personal winter wonderland.
Always Included
- Items to childproof guest rooms
- Cribs, high chairs and playpens
- Baby and children's toiletries
- Toys, colouring books and board games
- Children's DVD library
- All meals for children aged five and under from the Kid's menu in SIDECUT
- S'mores at the fire pit, or hot chocolate or lemonade in the lobby (seasonal)
Please provide us with the names and ages of your children so that we can be prepared with:
- A personalized children's newsletter
- Child-sized bathrobes
- Welcome stuffed toy on arrival


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The Apple's Best Ballaz
Donnie McGrath 6'3 PG JFK Somers
|Donnie is another city player that had a
great ABCD camp as he made the Senior All-Star game and finished 3rd in
the camp in assists. His strength is his jumpshot, if you leave him open
you can just count the 3. He does one thing well that most players don't
and that is shoot off the dribble. He can shoot off the dribble to his
right side, left side or off of a spin move. He is strong enough to take
it to the basket on take contact from big men and still finish. A drawback
to his offensive game is he doesn't take it to the basket enough. He
sometimes becomes one dimensional and sits behind the 3-point line. If he
takes it to the basket more and takes more mid-range J's he will be a
legit McDonald candidate. He is not a real strong defender, and has
trouble guarding quicker players.
2001-02 Season Outlook
Look for Donnie to put up numbers at JFK. This year he was the best player but he had 3 other players who could score but they are all gone, so look for him to take a lot of shots, and make a lot. He is the early favorite of Westchester player of the year and will make a strong push for Mr. Basketball. But don't expect a championship from his team.


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Phoenix Restraining Order Violation Lawyer
Highly-Rated Criminal Defense Firm Serving Phoenix, Arizona
If you've been served a restraining order, otherwise known as an injunction against harassment or order of protection, by the courts, you are expected to comply with its terms. A restraining order cannot be changed except through court action. Therefore, you cannot make contact with anyone named in the order or you will be in violation of the court – even if they initiate contact with you. Violations of these orders are considered serious legal matters by both courts and prosecutors and could result in harsh penalties being imposed against you. You will need an aggressive attorney on your side as soon as possible if you've been accused of a restraining order violation.
The Law Offices of Joshua S. Davidson can offer the help you need. Mr. Davidson's law practice is devoted solely to criminal defense. As a former prosecutor who routinely handled domestic felony cases himself, he knows how the other side thinks and builds its evidence.
With more than 20 years of experience, Mr. Davidson has a proven record that demonstrates a high level of legal ability and tenacity when it comes to fighting for the best possible result.
Restraining Order Violations in Phoenix
Even if the named victim on the restraining order initiates contact with you or expresses a desire to do so, you will be in violation if you communicate with him or her. Often times, restraining orders are used by "victims" as a way to enact revenge or control in emotional battles with domestic partners. This can happen in divorce and child custody cases or where unmarried partners have ended an intimate relationship. No matter what the circumstances, if you are found to have disobeyed any of the terms set forth in the protection order, you may be subject to immediate arrest and held in custody until you can appear before a judge who will make a decision concerning your release.
Restraining order violations, which are typically charged as the offense of "interfering with judicial proceedings" can result in a misdemeanor conviction punishable by up to six months in jail plus a fine of up to $2,500.
Free Consultation with a Phoenix Restraining Order Violation Attorney
Getting effective legal representation is imperative if you wish to make your side of the story known to the court in the most professional and legally compelling manner.
Contact us to schedule a free consultation so that you can learn more about your case and how Attorney Davidson can help you today.


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As a pediatric speech-language therapist, I find myself teaching toddlers the same first words over and over. Why? Because, based on the principles of speech sound development, I know which types of words will be the easiest for a child to imitate. And, I know what kids like! Combining those two factors together has led to a first words list that I keep tucked in the back of my head and rapidly sort through during therapy sessions as I find ways to sneak the words into toddler activities.
Parents are often amazed as their toddlers start talking quickly using these words. But what looks like magic is really just simple science. To arrive at this "magic" word list, I simply combine what we know about speech sound development with what what we know about the easiest syllable shapes. And, presto, words emerge.
Once a child has mastered words in one word list, I know he is ready for the next level. And up the word lists we go. This is especially effective for children who are diagnosed with apraxia of speech, but it works well for all children, typically developing or not.
So, what are these fabulous first words?
Bee, Bye, Ball (ba is okay), Bubble (buhboh)
Ni-ni, Nana (banana/grandma), Up, On, In, Out,
Two,Toy, Toe, Tree (tee) Eat, No, Neigh
The next step up
Mommy, Daddy, Num-num,
Nite, Hot, Hat, Hop Down, Done,
One, Dot, Toot, Elmo ("Emo")
Book, Bonk, Please (pees), See, Bed, Bike, Choo choo ("too too")
Block (bak), Big, Juice (doos), Off, Wet, Dirty (dihtee)


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Anything non-violet.
What is a peacenik's favorite color?
October 4th, 2012 — Uncategorized
What do hackivists have in common with the black bloc?
May 26th, 2011 — Uncategorized
They both hate windows
IMF Resistance's Poetic Response to the Haters
March 25th, 2011 — Uncategorized
IMFresistance just released their newspaper (pdf) for the weekend of actions. In it you'll find this sassy little poem:
We know we shouldn't riot but it feels too good to stop
Even though Naomi tells us that it's wrong to summit hop
From Bookchin down to Rebick, the same old glum refrain
Be sober and responsible, our struggle's not a game
But in all our local projects we've yet to feel the joy
Of masking up and throwing down to make total destroy
A fl aming dumpster in the street's a sight we thrill to see
Especially when hurtling toward five-O's APC
Some might say we have a problem, but we can't quite seem to care
When smoke from burning cop cars begins drifting through the air
A masked-up crowd, a teargas haze: to us a joyful frolic
But NEFAC keeps insisting that it's all merely symbolic
There might be a 12 step program but we haven't really looked
The sticky part for us would be admitting that we're hooked
But if you're a riot junkie too and need to get your kicks
Then come to DC in the spring – 'cause we've got your next fix
Haters gonna hate.
DC Bank Smashed Up, Kick-ass Communique Follows
December 23rd, 2009 — Uncategorized
This past week in Washington DC, some anonymous group of radicals broke the windows of a PNC bank. Banks get attacked all the time, why is this one so interesting? Shortly after the action, a communique appeared on AnarchistNews.org.
Here is the communique as it appeared on Anarchist News Dot Org:
Downtown DC, you aren't safe
Late on the night of December 17th, gleeful, adventurous children fell upon a PNC Bank in downtown Washington, DC on 15th and L St NW, breaking the windows with a loud crack! pow! boom!
The message: Everybody knows, PNC bank, you fucked up.
Blah blah blah, gentrification, blah blah blah, imperialism, blah blah blah, bailout.


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Beclin 1 (Becn1) is a key molecule of the autophagy pathway and has been implicated in cancer development. Due to the embryonic lethality of Becn1 homozygous deficient mice, the precise mechanisms and cell-type-specific role of Becn1 in the regulation of inflammation and tumor immunity remain elusive. Here, we report that myeloid-deficient Becn1 (Becn1ΔM) mice develop neutrophilia and hypersusceptible to LPS-induced septic shock, with a high risk of developing spontaneous precursor (pre)-B cell lymphoma with elevated expressions of immunosuppressive molecules PD-L1 and IL-10. Becn1 deficiency results in stabilization of neutrophil MEKK3, aberrant p38 activation, and neutrophil-B cell interaction through Cxcl9/Cxcr3 chemotaxis. Neutrophil-B cell interplay leads to activations of IL-21/STAT3/IRF1 and CD40L/ERK signaling, together regulates the programmed death ligand 1 (PD-L1) expression, and suppresses CD8+ T cell function. Ablation of p38 in Becn1ΔM mice prevents neutrophil-inflammation and B cell tumorigenesis. Importantly, low Becn1 expression in human neutrophils correlates with PD-L1 levels in pre-B ALL patients. Our findings have identified myeloid Becn1 as a therapeutic target of cancer immunity and immunotherapy for pre-B lymphomas.
Peng Tan, Lian He, Changsheng Xing, Jingrong Mao, Xiao Yu, Motao Zhu, Lixia Diao, Leng Han, Yubin Zhou, James M. You, Helen Y. Wang, Rong-Fu Wang
Despite progress in intensification of therapy, outcomes for patients with metastatic osteosarcoma (OS) have not improved in thirty years. We developed a system that enabled preclinical screening of compounds against metastatic OS cells in the context of the native lung microenvironment. Using this strategy to screen a library of epigenetically targeted compounds, we identified inhibitors of CDK12 to be most effective, reducing OS cell outgrowth in the lung by more than 90% at submicromolar doses. We found that knockout of CDK12 in an in vivo model of lung metastasis significantly decreased the ability of OS to colonize the lung. CDK12 inhibition led to defects in transcription elongation in a gene length– and expression-dependent manner. These effects were accompanied by defects in RNA processing and altered the expression of genes involved in transcription regulation and the DNA damage response. We further identified OS models that differ in their sensitivity to CDK12 inhibition in the lung and provided evidence that upregulated MYC levels may mediate these differences. Our studies provided a framework for rapid preclinical testing of compounds with antimetastatic activity and highlighted CDK12 as a potential therapeutic target in OS.
Ian Bayles, Malgorzata Krajewska, W. Dean Pontius, Alina Saiakhova, James J. Morrow, Cynthia Bartels, Jim Lu, Zachary J. Faber, Yuriy Fedorov, Ellen S. Hong, Jaret M. Karnuta, Brian Rubin, Drew J. Adams, Rani E. George, Peter C. Scacheri
Oral squamous cell carcinoma (OSCC) frequently invades the maxillary or mandibular bone, and this bone invasion is closely associated with poor prognosis and survival. Here, we show that CCL28 functions as a negative regulator of OSCC bone invasion. CCL28 inhibited invasion and epithelial-mesenchymal transition (EMT), and its inhibition of EMT was characterized by induced E-cadherin expression and reduced nuclear localization of beta-catenin in OSCC cells with detectable RUNX3 expression levels. CCL28 signaling via CCR10 increased retinoic acid receptor (RAR)β expression by reducing the interaction between RARα and HDAC1. In addition, CCL28 reduced RANKL production in OSCC and osteoblastic cells and blocked RANKL-induced osteoclastogenesis in osteoclast precursors. Intraperitoneally administered CCL28 inhibited tumor growth and osteolysis in mouse calvaria and tibia inoculated with OSCC cells. RARβ expression was also increased in tumor tissues. In OSCC patients, low CCL28, CCR10, and RARβ expression levels were highly correlated with bone invasion. OSCC patients with higher expression of CCL28, CCR10, or RARβ had significantly better overall survival. These findings suggest that CCL28, CCR10, and RARβ are useful markers for the prediction and treatment of OSCC bone invasion. Furthermore, CCL28 upregulation in OSCC cells or CCL28 treatment can be a therapeutic strategy for OSCC bone invasion.
Junhee Park, Xianglan Zhang, Sun Kyoung Lee, Na-Young Song, Seung Hwa Son, Ki Rim Kim, Jae Hoon Shim, Kwang-Kyun Park, Won-Yoon Chung
Treatment of tumors with ionizing radiation stimulates an antitumor immune response partly dependent on induction of IFNs. These IFNs directly enhance dendritic cell and CD8+ T cell activity. Here we show that resistance to an effective antitumor immune response is also a result of IFN signaling in a different cellular compartment of the tumor, the cancer cells themselves. We abolished type I IFN signaling in cancer cells by genetic elimination of its receptor, IFNAR1. Pronounced immune responses were provoked after ionizing radiation of tumors from 4 mouse cancer cell lines with Ifnar1 knockout. This enhanced response depended on CD8+ T cells and was mediated by enhanced susceptibility to T cell–mediated killing. Induction of Serpinb9 proved to be the mechanism underlying control of susceptibility to T cell killing after radiation. Ifnar1-deficient tumors had an augmented response to anti–PD-L1 immunotherapy with or without radiation. We conclude that type I IFN can protect cancer cells from T cell–mediated cytotoxicity through regulation of Serpinb9. This result helps explain why radiation of tumors can stimulate antitumor immunity yet also result in resistance. It further suggests potential targets for intervention to improve therapy and to predict responses.
Jianzhou Chen, Yunhong Cao, Bostjan Markelc, Jakob Kaeppler, Jenny A.F. Vermeer, Ruth J. Muschel
BACKGROUND Adenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary glands and other sites, characterized by high rates of relapse and distant spread. Recurrent/metastatic (R/M) ACCs are generally incurable, due to a lack of active systemic therapies. To improve outcomes, deeper understanding of genetic alterations and vulnerabilities in R/M tumors is needed.METHODS An integrated genomic analysis of 1,045 ACCs (177 primary, 868 R/M) was performed to identify alterations associated with advanced and metastatic tumors. Intratumoral genetic heterogeneity, germline mutations, and therapeutic actionability were assessed.RESULTS Compared with primary tumors, R/M tumors were enriched for alterations in key Notch (NOTCH1, 26.3% vs. 8.5%; NOTCH2, 4.6% vs. 2.3%; NOTCH3, 5.7% vs. 2.3%; NOTCH4, 3.6% vs. 0.6%) and chromatin-remodeling (KDM6A, 15.2% vs. 3.4%; KMT2C/MLL3, 14.3% vs. 4.0%; ARID1B, 14.1% vs. 4.0%) genes. TERT promoter mutations (13.1% of R/M cases) were mutually exclusive with both NOTCH1 mutations (q = 3.3 × 10–4) and MYB/MYBL1 fusions (q = 5.6 × 10–3), suggesting discrete, alternative mechanisms of tumorigenesis. This network of alterations defined 4 distinct ACC subgroups: MYB+NOTCH1+, MYB+/other, MYBWTNOTCH1+, and MYBWTTERT+. Despite low mutational load, we identified numerous samples with marked intratumoral genetic heterogeneity, including branching evolution across multiregion sequencing.CONCLUSION These observations collectively redefine the molecular underpinnings of ACC progression and identify further targets for precision therapies.FUNDING Adenoid Cystic Carcinoma Research Foundation, Pershing Square Sohn Cancer Research grant, the PaineWebber Chair, Stand Up 2 Cancer, NIH R01 CA205426, the STARR Cancer Consortium, NCI R35 CA232097, the Frederick Adler Chair, Cycle for Survival, the Jayme Flowers Fund, The Sebastian Nativo Fund, NIH K08 DE024774 and R01 DE027738, and MSKCC through NIH/NCI Cancer Center Support Grant (P30 CA008748).
Allen S. Ho, Angelica Ochoa, Gowtham Jayakumaran, Ahmet Zehir, Cristina Valero Mayor, Justin Tepe, Vladimir Makarov, Martin G. Dalin, Jie He, Mark Bailey, Meagan Montesion, Jeffrey S. Ross, Vincent A. Miller, Lindsay Chan, Ian Ganly, Snjezana Dogan, Nora Katabi, Petros Tsipouras, Patrick Ha, Nishant Agrawal, David B. Solit, P. Andrew Futreal, Adel K. El Naggar, Jorge S. Reis-Filho, Britta Weigelt, Alan L. Ho, Nikolaus Schultz, Timothy A. Chan, Luc G.T. Morris
Microtubule-associated serine/threonine kinase 1 (MAST1) is a central driver of cisplatin resistance in human cancers. However, the molecular mechanism regulating MAST1 levels in cisplatin-resistant tumors is unknown. Through a proteomics screen, we identified the heat shock protein 90 B (hsp90B) chaperone as a direct MAST1 binding partner essential for its stabilization. Targeting hsp90B sensitized cancer cells to cisplatin predominantly through MAST1 destabilization. Mechanistically, interaction of hsp90B with MAST1 blocked ubiquitination of MAST1 at lysines 317 and 545 by the E3 ubiquitin ligase CHIP and prevented proteasomal degradation. The hsp90B-MAST1-CHIP signaling axis and its relationship with cisplatin response were clinically validated in cancer patients. Furthermore, combined treatment with a hsp90 inhibitor and the MAST1 inhibitor lestaurtinib further abrogated MAST1 activity and consequently enhanced cisplatin-induced tumor growth arrest in a patient-derived xenograft model. Our study not only uncovers the regulatory mechanism of MAST1 in tumors but also suggests a promising combinatorial therapy to overcome cisplatin resistance in human cancers.
Chaoyun Pan, Jaemoo Chun, Dan Li, Austin C. Boese, Jie Li, JiHoon Kang, Anna Umano, Yunhan Jiang, Lina Song, Kelly R. Magliocca, Zhuo G. Chen, Nabil F. Saba, Dong M. Shin, Taofeek K. Owonikoko, Sagar Lonial, Lingtao Jin, Sumin Kang
The interleukin-3 receptor alpha subunit, CD123, is expressed on many hematologic malignancies including acute myeloid leukemia (AML) and blastic plasmacytoid dendritic cell neoplasm (BPDCN). Tagraxofusp (SL-401) is a CD123-targeted therapy consisting of interleukin-3 fused to a truncated diphtheria toxin payload. Factors influencing response to tagraxofusp other than CD123 expression are largely unknown. We interrogated tagraxofusp resistance in patients and experimental models and found that it was not associated with CD123 loss. Rather, resistant AML and BPDCN cells frequently acquired deficiencies in the diphthamide synthesis pathway, impairing tagraxofusp's ability to ADP-ribosylate cellular targets. Expression of DPH1, encoding a diphthamide pathway enzyme, was reduced by DNA CpG methylation in resistant cells. Treatment with the DNA methyltransferase inhibitor azacitidine restored DPH1 expression and tagraxofusp sensitivity. We also developed a drug-dependent ADP-ribosylation assay in primary cells that correlated with tagraxofusp activity and may represent an additional novel biomarker. As predicted by these results and our observation that resistance also increased mitochondrial apoptotic priming, we found that the combination of tagraxofusp and azacitidine was effective in patient-derived xenografts treated in vivo. These data have important implications for clinical use of tagraxofusp and led to a phase 1 study combining tagraxofusp and azacitidine in myeloid malignancies.
Katsuhiro Togami, Timothy Pastika, Jason Stephansky, Mahmoud Ghandi, Amanda L. Christie, Kristen L. Jones, Carl A. Johnson, Ross W. Lindsay, Christopher L. Brooks, Anthony Letai, Jeffrey W. Craig, Olga Pozdnyakova, David M. Weinstock, Joan Montero, Jon C. Aster, Cory M. Johannessen, Andrew A. Lane
Checkpoint blockade antibodies have been approved as immunotherapy for multiple types of cancer, but the response rate and efficacy are still limited. There are few immunogenic cell death (ICD)-inducing drugs available that can kill cancer cells, enhance tumor immunogenicity, increase the in vivo immune infiltration, and thereby boosting a tumor response to immunotherapy. So far, the ICD markers have been identified as the few immuno-stimulating characteristics of dead cells, but whether the presence of such ICD markers on tumor cells translates into enhanced antitumor immunity in vivo is still investigational. To identify anticancer drugs that could induce tumor cell death and boost T cell response, we performed drug screenings based on both an ICD reporter assay and T cell activation assay. We identified that teniposide, a DNA topoisomerase II inhibitor, could induce high mobility group box 1 (HMGB1) release and type I interferon signaling in tumor cells, and teniposide-treated tumor cells could activate antitumor T cell response both in vitro and in vivo. Mechanistically, teniposide induced tumor cell DNA damage and innate immune signaling including NF-κB activation and STING-dependent type I interferon signaling, both of which contribute to the activation of dendritic cells and subsequent T cells. Furthermore, teniposide potentiated the antitumor efficacy of anti-PD1 on multiple types of mouse tumor models. Our findings showed that teniposide could trigger tumor immunogenicity, and enabled a potential chemo-immunotherapeutic approach to potentiate the therapeutic efficacy of anti-PD1 immunotherapy.
Zining Wang, Jiemin Chen, Jie Hu, Hongxia Zhang, Feifei Xu, Wenzhuo He, Xiaojuan Wang, Mengyun Li, Wenhua Lu, Gucheng Zeng, Penghui Zhou, Peng Huang, Siyu Chen, Wende Li, Liang-ping Xia, Xiaojun Xia
Cancer-associated mutations in the spliceosome gene SF3B1 create a neomorphic protein that produces aberrant mRNA splicing in hundreds of genes, but the ensuing biologic and therapeutic consequences of this missplicing are not well understood. Here we have provided evidence that aberrant splicing by mutant SF3B1 altered the transcriptome, proteome, and metabolome of human cells, leading to missplicing-associated downregulation of metabolic genes, decreased mitochondrial respiration, and suppression of the serine synthesis pathway. We also found that mutant SF3B1 induces vulnerability to deprivation of the nonessential amino acid serine, which was mediated by missplicing-associated downregulation of the serine synthesis pathway enzyme PHGDH. This vulnerability was manifest both in vitro and in vivo, as dietary restriction of serine and glycine in mice was able to inhibit the growth of SF3B1MUT xenografts. These findings describe a role for SF3B1 mutations in altered energy metabolism, and they offer a new therapeutic strategy against SF3B1MUT cancers.
W. Brian Dalton, Eric Helmenstine, Noel Walsh, Lukasz P. Gondek, Dhanashree S. Kelkar, Abigail Read, Rachael Natrajan, Eric S. Christenson, Barbara Roman, Samarjit Das, Liang Zhao, Robert D. Leone, Daniel Shinn, Taylor Groginski, Anil K. Madugundu, Arun Patil, Daniel J. Zabransky, Arielle Medford, Justin Lee, Alex J. Cole, Marc Rosen, Maya Thakar, Alexander Ambinder, Joshua Donaldson, Amy E. DeZern, Karen Cravero, David Chu, Rafael Madero-Marroquin, Akhilesh Pandey, Paula J. Hurley, Josh Lauring, Ben Park
Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease with diverse drivers of disease progression and mechanisms of therapeutic resistance. We conducted deep phenotypic characterization of CRPC metastases and patient-derived xenograft (PDX) lines using whole genome RNA sequencing, gene set enrichment analysis and immunohistochemistry. Our analyses revealed five mCRPC phenotypes based on the expression of well-characterized androgen receptor (AR) or neuroendocrine (NE) genes: (i) AR-high tumors (ARPC), (ii) AR-low tumors (ARLPC), (iii) amphicrine tumors composed of cells co-expressing AR and NE genes (AMPC), (iv) double-negative tumors (i.e. AR-/NE-; DNPC) and (v) tumors with small cell or NE gene expression without AR activity (SCNPC). RE1-silencing transcription factor (REST) activity, which suppresses NE gene expression, was lost in AMPC and SCNPC PDX models. However, knockdown of REST in cell lines revealed that attenuated REST activity drives the AMPC phenotype but is not sufficient for SCNPC conversion. We also identified a subtype of DNPC tumors with squamous differentiation and generated an encompassing 26-gene transcriptional signature that distinguished the five mCRPC phenotypes. Together, our data highlight the central role of AR and REST in classifying treatment-resistant mCRPC phenotypes. These molecular classifications could potentially guide future therapeutic studies and clinical trial design.
Mark P. Labrecque, Ilsa M. Coleman, Lisha G. Brown, Lawrence D. True, Lori Kollath, Bryce Lakely, Holly M. Nguyen, Yu C. Yang, Rui M. Gil da Costa, Arja Kaipainen, Roger Coleman, Celestia S. Higano, Evan Y. Yu, Heather H. Cheng, Elahe A. Mostaghel, Bruce Montgomery, Michael T. Schweizer, Andrew C. Hsieh, Daniel W. Lin, Eva Corey, Peter S. Nelson, Colm Morrissey


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[weaver_extra_menu menu='pregnancy_app_menu' style='menu_bar' width='width_override' css='extra_css']
Primal Bonding
Please look to what you think a 'safe' birth is . .
I believe it is when mum and bub are bonded as mammals. As nature intended. With hormones. Undisturbed by any external manipulating.
Birthing perfection. Falling in love with each other. No 'what if's'.
How a baby is born affects all life for that child, and that couple forever.
Would you leave it to those who are not living in your lives to do as they will?
is there a more conscious way? Many find their own answers.
Here I hope that you open your eyes to what else and why you might not take the road most travelled – as your duty of care is to your children – not the prevalent mind set of the 'best practice' of the modern medical dictates – as they have not stood the test of time – mammalian undisturbed birth got us all to here – we are the survivors of people thinking and acting independently.
How do you want to be meeting the most important little person you will ever be bonded to?Fathers, the engrossing first moments – in fear and distress?
Your choice… Who do you listen to?
The possibly 'it might go wrong's' or the 'of course it will just pop out's"?
Here is a selection of what can be found on the net without too much trouble – and before you judge the concept of birthing at home (it is actually vastly safer than a hospital birth for 'low risk' pregnancies, which yours most likely is) and discount it – perhaps read one dad's account. Secrets of a home birth dad are equally secrets of a bonded dad.
Life is about relating – not waiting for things to go pear shaped.
Breastfeeding and 'the long haul'
Though this man went through four births before they got it right. This is a pertinent question – as few ask about what you want next.
Just work on fears of what you have no idea about.
Birthing is the instant your baby gets to be imprinted for life – and the violence and the horror that sometimes awaits – and all the noises and the pain and the messing with nature does not have to happen – if you work out that women are meant to birth easily and whatever you can do to enhance her life so she gets this is the biggest gift you can give your baby, baby's mum and yourself – as happy families are made by what you choose not react to do – each minute.
The relating that happens – and the quality for all that you put in determines all that follows.
Refer to 5 jobs for dad to do at birth
I would add – be her advocate – and her epidural – easy – follow all that has worked for others that is in the safe, practical, easy to follow 'glove box manual' style handbook – in What Dads Can Do and in these instantly downloadable books. This work has been developed over 35 years and is the distillation of one woman's life work in helping binding at birth – for the mum and dad to go into being a family together.
Please – get the eBook package and become involved – it is your baby and your life.


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1. What kind of return did you get on your investment?
I get every month $200 paid directly into my account. Plus extra when all expenses are covered for a particular period.
2. How easy was it for you to do?
Quite easy. I had the trust in this couple, signed papers and never regret it. The new buyers they put into my property to date never failed in making their payments on time.
3. What was the length of the transaction?
About 3 years so far.
4. Would you recommend our services to others who may be interested in real estate investing?
Yes, I would
5. Any other comments?
Paul and Karen came to my rescue when I was desperately looking for a way to turn my negatively geared property into something promising. The fact that I was some 2 1/2 out from my property location, I couldn't think of anyone better to take care of things for me other then Paul and Karen Dobson.
They shared a strategy which I felt make sense. To confirm that this strategy works is that I've duplicated that same strategy over time now and see the fulfilling pleasure in doing so.


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New Harmony Town has a small but well kept cemetery. Many of the founding fathers and their families are buried here. A directory of the graves is located on the cemetery shed for anyone looking for ancestors. Plots are available for purchase by contacting the town clerk at 435-865-7522.
The Town park is located next to the fire station. It is fenced and has state-of-the-art playground equipment along with the traditional toys. Horse shoe pits, a baseball backstop, and picnic tables are all available for day use and the park can be reserved for special events by contacting the town clerk. Councilman Curtis Hadley is over the Cemetery and Park you can reach him at 435-865-2862 if you have any questions or comments.
The Town also has a nature park called the Comanche Nature Park. This areas encompasses a 40 acre tract of land west of town. The nature park has hiking trails, and picnic tables.


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Located at Anilao Batangas, Anilao Haven Resort offers beachfront access and amazing chill spots right by the shoreline. The resort has pavilions and meeting rooms for ideal for various seminars and social functions. After a long day at the beach, guests may request the Wat Po therapeutic massage. A sauna room and spa pool are also available for unwinding and pampering. The resort has complimentary WiFi access, ensuring that guests can remain connected during their stay.
Anilao Haven Resort has an excellent selection of rooms suitable for all guests. The rooms are classified into four types: Premier, Deluxe, Executive and Studio. All rooms are well-equipped with standard amenities such as air conditioning, flat screen LCD television, satellite cable, built in closet, phone intercom, coffee table, and WiFi access. The rooms also have private bathrooms with bathtubs and hot/cold shower. The rooms also have veranda perfect for relaxing with friends and families.
Anilao Haven Resort is 117.7 km away from Ninoy Aquino International Airport.
At Anilao Haven Resort, guests can enjoy the beautiful beaches of Anilao. Lodgers can even visit the famous Sombrero Island, perfect for scuba diving and snorkeling. Trekking at Mt. Gulugod Baboy is also a great activity to do during your Anilao trip.
|Mabini Anilao, Batangas City, Batangas (Show Map)
|About an hour and a half from Tagaytay via Talisay-Tanauan road and Bauan-Batangas Provincial Road.
Directions & Landmarks
Take 5 minutes boat to the resort from the mainland.
Room Facilities
Room Amenities
Hotel Facilities
Disclaimer: It is the responsibility of the hotel chain and/or the individual property to ensure the accuracy of the photos and information displayed. Travelbook.ph is not responsible for any inaccuracies.
We stayed in this place for our business development meeting. You need to ride a boat to reach the place. The boat ride was approximately 10 to 20 minutes and it cost 2500. When we arrived at Anilao Haven Resort, the staff is quite friendly. He showed us where we will stay and then prepared the room for us. The room is cool enough but don't forget to close the door always otherwise you will feel the heat. The aircon is just 0.5 hp I think. The bathroom is clean but the water pressure is quite low so it may take awhile for you to take a shower (not a big deal). There are stores nearby so you can buy some stuffs that you might need. You can buy charcoal, soap, ice, etc from the store.3 Things You Love about This Hotel: not crowded, clear water, average Room: Villa Room - Villa Room Stay Date: 05/16/2015 to 05/17/2015
Super ganda ng beach and the white sand. Okay nman ang room sana kaso may butas ang bubong.kaya balewala ang aircon. Super init. Buti nalang maganda ang beach kaya d n nmin npansin ang panget na room. I love to go back again. Okay nman sa resort. Kulang lanh ng tao para nag asikaso sa guest.3 Things You Love about This Hotel: manong ted is good, the place is really beautiful, i love the white sand Room: Villa Room - Villa Room Stay Date: 04/03/2015 to 04/04/2015


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So you want to go to Myanmar? Just don't. Why not? Read on.
1. Lake Inle is just like any other freshwater lake
How unremarkable! The lake in your neighborhood probably has entire houses, gardens and monasteries that float on the waters too.
2. And Bagan? Just your average skyline
Such a rotten view. Keep those eyes closed!
3. Who would want to visit the same place as President Obama?
Sure, the Shwedagon Pagoda is one of the most famous pagodas in the world visited by celebrities and world leaders, but hey, why would you want to as well? Avoid at all costs.
4. There's nothing intriguing about the food
Nothing really appetizing about the sweet and sour, salty and spicy catfish noodle soup, also known as mohinga.
5. not much to shop for here
We're sure you can pick up hand-painted paper umbrellas, sand paintings, colourful Longyis, local lacquerware and copper bells like this at your nearest mall.
6. everyone just sits around bored most evenings. nothing to do.
6. Not to mention, the country is historically disappointing
Would you really want to waste your time visiting a country dotted with ancient temples and historic sites?
7. And the local experiences are passe
Just your average fishermen rowing a boat with one leg whilst catching fish. Nothing special.
8. PLUS the locals just hate travellers
Obviously, all those smiles are faked.
So, there you go.
Now, why anyone would want to explore a land of golden pagodas, floating villages, delicious food and kind, welcoming people? Beats us.
Related Products
Featured image source: Travel Asia Blog
Written by: Vandita Jadeja
This post first appeared on Why Not To Travel To Jordan | BYOND, please read the originial post: here


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Event Registration
October 26, 2012
Rachel Carson Legacy Conference
Our Planet and Our Health - The Impact of Silent Spring after Fifty Years
Rachel Carson's book Silent Spring, published 50 years ago in 1962, brought global attention to the consequences of unrestrained use of toxic pesticides such as DDT. Among the actions taken in response to her work was a ban on DDT by the newly formed environmental Protection Agency in 1976, over a decade after Rachel Carson's death. The conference will gather participants from academic, non-government, industry, advocates and policy makers to explore the topic: "Our Planet and Our Health - The Impact of Silent Spring after Fifty Years". View more details.
Registration Form
Ticket prices are $50 per person ($20 for students).
Chatham University students, faculty and staff can register for free on myChatham.
All fields marked with * are required


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August 26, 2004 — Cool new article and picture!
Check out the Maitland Mercury's latest article about Rhiana, and feast your eyes on the gorgeous picture of her they printed with it! It's from the same photo shoot, by photographer Shelley Cornish, as the "Angel" picture we used in our banner! We have no idea which horror movie Rhiana has auditioned for, but you'd better believe our fingers are crossed!
Go Rhiana! You rule, as always!


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Another presentation I gave at the General Online Research (GOR) conference in March1, was on our first approach to using topic modelling at SKOPOS: How can we extract valuable information from survey responses to open-ended questions automatically? Unsupervised learning is a very interesting approach to this question — but very hard to do right.
Continue reading "Using Topic Modelling to learn from Open Questions in Surveys"


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BZ Paintball Supplies
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Note: These shrouds are labeled 8 inches, 12 inches, 14 inches, and 18 inches because that is the barrel length that they match best with. For players who need exact lengths of these shrouds it is as follows:
8 inch shroud is actually 6 3/4 inches
12 inch shroud is actually 10 1/4 inches
14 inch shroud is actually 12 1/4 inches
18 inch shroud is actually 16 1/4 inches
Free If you spend over £50.
Order before 2pm for delivery within 5 working days.
Delivery excludes Sundays and bank holidays
- Paintballs, because of weight and fragile nature(these can only be sent by DPD).
- Pyrotechnics, because these have to be sent with a specific courier
- Gas tanks, because Royal Mail will not transport
Order before 2pm to receive your order the next working day
Orders placed after 2pm Thursday will be delivered on Monday
Orders placed after 2pm Friday, or over the weekend will be delivered on Tuesday
If you provide a mobile number you will receive an SMS on the morning of delivery with a 1 hour delivery window
Delivery excludes weekends & bank holidays
Order before 2pm on Friday to receive your order on Saturday
If you provide a mobile number you will receive an SMS on the morning of delivery with a 1 hour delivery window


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The DSL-320 Opacity Monitor is an optical instrument designed to measure the visible opacity of exhaust gas in a duct, stack or flue.
The DSL-320 uses the double pass light transmission measurement technique, with a folded beam Transceiver/Reflector arrangement. A light beam emitted from the Transceiver (TRX) passes across the duct, stack or flue to a Reflector, which then returns the light to the Transceiver where the intensity of the received light is measured. Increased particulate or smoke density in the stack gas attenuates the transmitted light and causes the intensity of the received light to fall. This reduction in intensity is measured and presented as % opacity. The higher the level of particulate or smoke present, the more light lost and therefore, the greater the opacity.
- In situ measurement directly in exhaust gas flow
- Measurement reading as % Opacity
- Modulated green LED source for long lifetime stability and immunity to ambient light
- Rugged 316 stainless steel construction
- In-situ zero and calibration check facility
- Choice of interface options enabling easy integration
- Free utility software for PC based set-up control and data logging
- Optional Operator Interface with different mounting configurations
- Simpler installation than single pass opacity monitors
- Better accuracy over shorter path lengths than single pass opacity monitors
- Rugged design with no moving parts so low maintenance
- Latched head and lid design to enable ease of access for installation and maintenance
For further information and technical specifications about this product please contact us via phone or email and a member of our team will be happy to help


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Unsuspecting women in Leeds city centre are being targeted by an online pervert who is secretly filming them and uploading the clips to a porn website.
Dozens of videos, which have amassed thousands of hits, have been captured at prominent locations including Trinity Leeds, Kirkgate Market and The Light shopping centre.
The slow-motion clips feature mothers with prams, students going to the gym, women shopping, a young woman on crutches and an older woman on a mobility scooter.
West Yorkshire Police is urging anyone who fears they have been targeted to contact them immediately.
The videos, some of which are labelled 'British Thigh Gap', 'Leeds Tights' and 'British Teens', have been uploaded to porn website XHamster.
Some include 'up-skirt' shots of women who are seemingly unaware they are being filmed as they use escalators in shopping centres.
Many of the short films have been shot at well-known city centre locations, such as Kirkgate Market, The Light, Trinity Leeds, Albion Street and The Headrow.
Insp Richard Clarke, who heads the City Neighbourhood Policing Team, said: "While at face value the footage is not overtly sexual, the way in which these women have been filmed apparently without their knowledge and the fact it is being posted to a pornographic website raises concerns about the person who is doing this."
He added: "We have not had any complaints in relation to these incidents but if anyone does have concerns that they have been targeted by this person they should contact us.
"My officers are liaising with security teams at businesses in the city centre and if anyone sees anyone acting suspiciously in this way they should contact us immediately via 101."
Crime-fighting network BACIL (Business Against Crime in Leeds) has also urged shop owners and employees to stay vigilant.
A BACIL spokesman said: "We appear to have someone following women around the city centre filming them walking about on a mobile phone and posting the footage on an adult website.
"If anyone sees this happening contact the police so the offender can be stopped."
No-one at the website was available for comment.


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Chris began her career with Belmont University in March 2004 in the School of Music as the MPAC Facilities Secretary. In 2006 she moved to the School of Education as the Database and Practicum Coordinator and eventually obtained her current position in the CAS Dean's Office as Budget Manager and Adjunct Coordinator in May 2008. She loves working at Belmont and particularly her job in the Dean's Office. "It is so fulfilling to work with all the great Faculty and Staff within the College as well as colleagues throughout the University."
Prior to moving to Nashville in October, 2003, she worked in a public school system in San Diego County, California as a Counseling Assistant. Before working for the State of CA she was self-employed in various business ventures including Real Estate, Property Management, Financial Planning, and as a Holistic Health Practitioner and Massage Therapist. She has three children and two grandchildren who live in Oklahoma City, OK, Nashville, TN, and Los Angeles, CA. She graduated from Belmont University in August 2010 with her Bachelor of Science in Liberal Studies. Chris' hobbies include flipping houses, gardening, traveling, reading and playing with her dog.