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Berlin | a weekend guide of healthy eating
When travelling abroad, there are those cities that are just beautiful. Paris, Vienna, Prague, Rome. You pack your weekend cabin bag and fly over to "break the city", check a number of tourist attractions, eat traditional dishes, and walk around the sides of the capital's river.
Berlin is not that kind of city. I've never heard someone talking about Berlin as the city with impressive cathedrals, beautiful parks, amazing museums, or inspiring architecture.
About 4 years ago, I was lucky enough to get an internship offer from a company in Berlin. A journey that started as the crappiest weeks of my student life soon became the experience of a lifetime. During the 5 months I lived there, I realized that Berlin never takes things too seriously. It just widely opens its arms and welcomes you with a blend of diverse people, iconic sights, and vibrant history. All furnishing a unique set of "zenifying" vibes.
I left the city with a mental picture of "the urban Vama Veche" and had planned to go back to see its development.
Three years later, I went back.
A different me, a more grown up Berlin. I quickly realized it was hard to keep up. Because even if I had constantly checked out the new Hot Spots online, the city speed over passed those of my megabytes.
I also realized that my traveling notes after a full weekend NOW shape to a "healthy itinerary", guided by places with honest and delicious food, nutritious smoothies, and fair prices. I'll leave this itinerary here, and I hope that when you'll visit Berlin, you'll find this useful.
Saturday | Smoothies, Avocado Bowls, Asian delights
Breakfast: THE BOWL
Just when you go out at Warchauer Str., look right and cross the street. They have a generous smoothie selection and, as the name clearly states, great bowls of healthiness. We ordered Buddhist & Californian Bowls.
Lunch: Monsieur Vuong
We asked around for one of the most authentic Vietnamese restaurant there was. And since traditional German food is not something we really craved for, we went for Monsieur Vuong. We ordered "our classic": fresh shrimp rolls, pho, and mango salad.
Dinner: Shiso Burger
I researched the best burger places in Berlin (initiative generated via a masculin influence) and we ended up choosing (again!) the Asian interpretation. At Shiso they have amaaaaazing edamame & a handful amount of vegetarian / fish burgers. The 15km walked around the city definitely helped in finishing our meals 🙂
Sunday | Wake up laughing. Brunch & dine as a Berliner
Easy as that. Went to Rewe, bought two smoothies & one jar of natural organic yogurt. Eating the homemade granola I had brought with me out of a hotel glass – with no spoon! – only filled our morning with laughter.
Brunch: Gipfeltreffen
To be honest, we were not impressed by the food (although it was good), but the street atmosphere was so nice that we just blended into the city. Aso, the Görlitzer Park is right nearby and you can have a nice hipsterish walk. I find this one more authentic than Mauer Park, which is too crowded due to its mentioning across tourist guides.
Dinner: DuDu
The place was recommended by a trustful friend who lives there. We found it chic, yet minimalist. Starting with spicy edamame (I am a bit obsessed, I admit) followed by a Fusion Sushi Lovers Plate. Hearts hearts hearts, we loved it!
And even if I mentioned quite a few places, what this city has to offer is SO much more! But when and if you'll go to Berlin, just remember one thing:
It's not about how it looks, it's about how it feels.
Photo credits: @corinan, Monsieur Vuong, DuDu


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In an article that appears in this week's edition of Real Estate Weekly (but is not available online), Stephen Pozycki, head of New Jersey-based SJP Properties, discusses the state of the New York City commercial real estate market in light of the recent U.S. economic woes. SJP, as you may recall, is building the speculative, LEED Silver 11 Times Square at the corner of 42nd Street and 8th Avenue (just across the street from the New York Times Tower).
Last fall, we discussed the project in the context of the subprime lending meltdown and what it might mean for green building generally. Pozycki told Real Estate Weekly that he expects the tower to be half-filled with tenants by summer and that "[t]here's just not many of these new green buildings that are being built in the city." He noted the lack of available space in new green towers from the Times, Hearst, Bank of America, and also pointed to Boston Properties' plans for a LEED Gold building, targeted specifically for law firms, at West 55th Street. (Renderings of the Skidmore Owings & Merrill-designed building, which has already secured two long-term leases with Gibson Dunn and Proskauer Rose, were just released earlier this week). "Tenants will come [to 11 Times Square]," he said.
The article also suggests that the similarly speculative 510 Madison Avenue may also able to survive an economic downturn thanks to its target roster of high end financial services tenants. Nevertheless, SJP is in the position to stop construction and wait until it secures an anchor tenant, as the tower has yet to get out of the ground, but Pozycki remains confident that it will open up as scheduled in the summer of 2009. Coupled with the new Boston Properties tower, 8th Avenue's transformation into Midtown's sustainable thoroughfare looks like it will continue to move forward as expected, despite the continued market uncertainty.
- 11 Times Square and the Subprime Meltdown (gbNYC)
- 510 Madison Avenue (gbNYC)
- Rendering of 250 W. 55th Revealed (Real Deal)

subset: commoncrawl


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Tens of Thousands of Fossils in Amber Refute Evolution May 18, 2008Posted by ayaat in sciences.
Tags: Evolution, Fossils
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The theory of evolution has been consigned to history, and living fossils are the greatest proofs of this.
Were We exhausted by the first creation? Yet they are dubious about the new creation.
We created man and We know what his own self whispers to him. We are nearer to him than his jugular vein.
(Qur'an, 50:15-16)
24-Million-Year-Old Fossil Flies
24-million-year-old fossil flies (Diptera).
Don't you know that God knows everything in heaven and Earth? That is in a Book. That is easy for God. They worship besides God something for which no authority has come down, something about which they have no knowledge. There is no helper for the wrongdoers.
(Qur'an, 22:70-71)
Everything in the heavens and Earth belongs to God. God is the Rich Beyond Need, the Praiseworthy.
(Qur'an, 31:26)
These Living Things Have Not Changed At All over Millions of Years
50- to 40-Million-Year-Old Baltic Ambe
No Such Process as Evolution Ever Took Place.
Every fossil concealed inside a piece of amber is a manifestation of the sublime artistry exhibited by God over millions of years.
These Living Things Are the Kind We See All the Time in Our Gardens or in the Street.
Humanity! An example has been made, so listen to it carefully. Those whom you call upon besides God are not even able to create a single fly, even if they were to join together to do it. And if a fly steals something from them, they cannot get it back. How feeble are both the seeker and the sought!
(Qur'an, 22:73)
Evolutionists seek to make people believe that millions of years ago the Earth was a very different place, filled with strange creatures. Yet the same insects were flying millions of years ago as are flying today. The same fish were swimming, and the same spiders were spinning webs. God, Who creates them now in the most perfect form, has the power to create the same perfection whenever He wills.
What is in the heavens and in the Earth belongs to God. God encompasses all things.
(Qur'an, 4:126)
Not A Single Example of An Intermediate Form Has Ever Been Discovered among Fossil Findings.
Fossils that Are Tens of Millions of Years Old Are Identical to Present-Day Specimens.
Had evolutionists encountered a single intermediate form among all the countless fossils they have obtained—something which is in any case impossible—they would have doubtless used this as evidence and written countless numbers of books about it. There is only one reason why evolutionists are silent on the subject of the fossil record: that all fossils proclaim the fact of creation.
This is God's creation. Show me then what those besides Him have created! The wrondoers are clearly misguided. (Qur'an, 31:11)
The Earth perfectly preserved the fossils it has contained for millions of years. Countless fossils collected from all over the world reveal the most important truth, that all living things are the work of Almighty God.
The Fossil Record Has Shown the Fact of Creation. That Is the Sole Reason for Evolutionists' Silence on the Matter.
Darwinism's claim of transition is a falsehood. As today's living fossils prove, living things did not evolve. The present-day Earth is teeming with species that existed in their current form millions of years ago. However, not one example of Darwinism's imaginary intermediate forms has yet been unearthed.
There is no one in the heavens and Earth who will not come to the All-Merciful as a servant. He has counted them and numbered them precisely. Each of them will come to Him on the Day of Resurrection all alone.
(Qur'an, 19:93-95)
Evolution Is A Lie.
Living Things Have Never Undergone Any Changes.
These creatures, which lived on the Earth millions of years ago under the conditions at that time, have survived unchanged down to the present day. Millions of generations have passed away in the meantime, but these fossil species are identical to their present-day counterparts. Evolution via "survival of the fittest" as claimed by Darwin and his followers never took place. All these present-day living fossils clearly demonstrate the stasis in the history of life.


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joe francis
didn't see my pic for dec 27. are there more coming?
Sarah Moon
I didn't see my pic from the show on the 27th! 🙁
Cindy Lou Cruz
I didn't see my pic??
Please post
Cindy Lou Cruz
Still I haven't seen my pic! I am a regular customer, paid my VIP
I was wearing a, burgundy hat and duster, standing next to Billy.


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A report has been published showing that women who have children lag behind men in the pay stakes. It comes from the Institute of Fiscal Studies and mirrors a similar report produced by the TUC in March 2016.
On average, women earn 18% less per hour than men, according to the IFS research. However, this gap between men's and women's hourly pay rates has been closing in recent decades – it was 23% in 2003 and 28% in 1993.
But after women return to work following the birth of a first child, that wage difference per hour widens steadily."This apparent wage penalty for taking time out of paid work is greater for more highly educated women, at 4% for each year out of paid work," the IFS found.
"The lowest-educated women (who actually take more time out of paid work after childbirth) do not seem to pay this particular penalty, probably because they have less wage progression to miss out on."
I tweeted about this report and very helpfully a lovely chap pointed out to me that it was probably because men were better respected in the workforce than women. I hope you will be proud of me, dear reader, because I forbore to reply.
Surely it is the mark of a civilised society that we make equal arrangements for women and men to be involved in parenting and not suffer a penalty? The world needs women to have children and children need good parenting. The world also needs a diverse, and gender equal group of people running it.
If you'd like to download a copy of the full report this link will take you to the page on the IFS website.
RenewYou is our on day course for women, to empower an inspire. If you're interested in delivering this course to women and passionate about women's development, take a look here.
Posted on August 24th, 2016 by Jane


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Lady Gaga's new music video for "G.U.Y." has everything you'd expect from a GAGA video: Money, The Man, butts, plastic capes, a relentless search to match all sexual positions to it's corresponding dance position. But something popped up even more unexpected. Why we know Gaga get's down on some Minecraft in her free time the new video has a scene where she and Minecraft YouTube personality Sky Does Minecraft use the game to resurrect Jesus, Ganhi, and Michael Jackson. Yep, you read that right. Now I'm not suggesting anything as rash as watching an entire Lady Gaga video (Skip to 5:20 for the Minecraft bits) but she does aim to please the masses.
Carrying on this heavy-handed theme of art – we get it Gaga, you've been to the Discovery Time Square, she also appears as Nathan Sawaya's Lego scultpure Yellow. But I'm certainly not one to judge, knowing so little about art, I've never even let anyone vomit on me.
RELATED: 10 Video Game Mashups the Complex Staff Wish Existed
RELATED: Watch Lady Gaga Get Puked on During Her SXSW Performance by "Vomit Painter" Millie Brown
RELATED: Lady Gaga Runs "Minecraft" While Rocking Gunnar Optiks
[via DailyDot]


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The first step in determining the nature of this anomoly was to be sure that it wasn't just an artifact of some sort; did it exist on other's images taken at other times? Was it indicated on any maps of this crater? If so that would provide positive proof that this is a real feature of some sort or another and not an artifact of light, shadow or photography.
So...turns out it's real enough; it is present on numerous images of this crater such as this image taken by Oliver Pettenpaul-- and is also indicated in the same location on the Rukl chart as well. It also shows up on an Apollo image"
So it is actually there. But is it a ghost crater? Or is it instead just a chance alignment of otherwise unrelated features that we only *see* connected as a circular formation at lower resolutions?
To help find some hints to help settle this question I felt that a higher resolution look at the area would be helpful so I dug up this Ranger mission image:
At this high resolution and at this high sun angle the feature seems to dissappear! At first blush this would seem to argue strongly for the 'optical illusion' explanation of this circular anomoly. But let's look closer.
I've marked the supposed location (rim) of the possible ghost crater as well as the clear craterform present to the immediate north. Also marked are two features that argue towards this being the remnants of a crater formed prior to floor "flooding"-- in Alphonsus' case by Cayley formation material rather than lavas (though there exists some question about this--more later).
The first evidence for this feature being a ghost is the linear block aligned along the putative wall, indicated by an arrow. This is the sort of feature geologists call 'anomolous' (until it's explained) as there is no obvious explanation for it's presence. It's a linear ridge where there is no reason for a ridge, especially in this perpendicular orientation, to exist. Contrast this feature to the more easily explained but similar feature indicated by the arrow labelled 'slump block'--this is obviously a chunk of crater wall that fell down onto the floor--we can tell this by both it's location near to the wall and it's roughly parallel orientation to the wall as well. But for the former block no such easy explanation is evident--it's orientation is wrong as well as it's distant location to the wall--it's not a slump block. But, if seen as a remnant of a crater wall, *that* would explain it's presence quite tidily.
The second feature arguing for a crater form here is the generally curved and elevated area indicated by the small arrows which, at lower sun angles, serves to define the 'circularity' of this formation as seen visually. This arc is quite evident even in the Apollo image linked to earlier. That this elevated & curved area is coincident with the linear block examined earlier, continues to auger for a craterform explanation for this feature.
There is also circumstantial evidence to be found in the literature for the presence of ghosts generally in these particular central highland areas. For example Ptolemaeus, the neighbor to the north, has a number of subsumed craterforms evident on it's surface. As both Ptolemaeus and Alphonsus are ancient (pre-nectarian and nectarian age respectively) craters and thus subject to similar post-formation impact histories, what is said about Ptolemaeus should also apply to Alphonsus in this regard. Also, both these craters are blanketed with Cayley formation material--forming the light plains found in this part of the central highlands.
Lastly, anomolous blocky remnants of rims of craters, as well as basin rings for that matter, are not unknown nor unrecognized. Indeed, more than one basin ring is considered to be marked only by otherwise unexplained & isolated mountain peaks.
More on the Cayley formation-- it is most commonly considered to consist of a thick blanket of ejecta cast out during the latter stages of the formation of the Imbrium basin (immediately after the ballistic ejecta which formed the Imbrium sculpture so evident in this area). This is the material, not mare lavas, which fill craters in this area, like Ptolemaeus and Albategnius, and give their floors the flat mare-like appearance we note telescopicly. (Wilhelms) Some speculate that Cayley deposits may consist of later deposits from Orientale basin formation as well (Hodges, Chau). Still others posit a possibility of the presence of highland lavas that differ in mineralogy and thus in albedo from mare lavas (Wood) as having a role of unquantified extent in forming these particular crater plains. As far as I can tell the question is not settled as to the exact nature of this material, but it is agreed that there is an emplacement of *something* of a significant thickness blanketing these areas--more than sufficient to subsume craters formed prior to the emplacement of the overlying material.
Based on the reasoning & evidence above i feel it's a pretty sure bet this is indeed a ghost craterform on Alphonsus' floor. And so concludes another investigation into a question that probably no one but me has ever bothered to even ask! :lol: But this, to me, is what makes the Moon so interesting--as a body that is known enough and accessable in enough detail to both faciltate forming and answering questions regarding features of such relatively small scale as this-- represents a unique investigative opportunity for amateurs even when armed only with small telescopes and cheap cameras!
Comments and criticisms welcome as always.
Carol Lakomiak made the following comment: "Wouldn't the impact of the ghost have punched down that section of Al's inner wall and left a depression which would then have been covered by the Caley material?" (used by permission)
My response:
That's a very interesting observation--about the lack of apparant effect upon the pre-existing wall! Legitimate and spurred me to look at this closer this am.
Still, I agree the ghost crater *is* involved with the wall to a certain extent...but I don't think there would necessarily be a depression in Alphonsus' wall still visible for two reasons; 1) because the ghost is almost completely subsumed by the Cayley deposits...only remnants of the very uppermost rim are still evident and since there is usually little disturbance of the pre-existing wall beyond the rim of an in-crater impactor like this, thus no divot/depression etc would be expected--as any such would be buried, along with that portion of Alphonsus' wall and 2) the slope of the interior of the smaller crater would be closely congruent with the slope of the impacted wall in any case and the difference could easily be erased by the combined effect of mass wasting and burial by Cayley material.
Also--look again at the much more unambiguous crater form directly north and adjacent to the ghost--this crater has seen a large block of Alphonsus' wall slump into it--in fact much of it is destroyed due to later infall of the neighboring wall--the effect upon the larger wall in this case is not negative but positive. Post-impact modification like this isn't unknown.
I thought to look at more pristine examples of this type formation on the Moon to see how a crater like this could have appeared prior to burial by the Cayley deposits...
For example, take crater Licetus:
Here is a pre-existing crater which has a much more involved and larger crater impacted even deeper/higher into it's inner wall. Notice the lack of deformation of the wall of the original crater even though this is a much larger crater than the Alphonsus ghost--and how the new crater's wall layers it's own interior slope into the wall's pre-existing slope. Sort of a bowl within a bowl...Bury this formation so only remnants of the small crater are still visible and there would be no depression visible on the impacted wall either.
I found other examples of this pattern--Vlacq, Metius, Neander, Isadorus, Rheita, and many more all have small craters involved to one degree or another with their inner walls, all show little to no effect outside their wall-ward rims upon the original crater wall --and if one imagines them buried to their very rims with many dozens of meters worth of particulate material (Cayley), a great deal of blending of small differences in slope, elevation and definition generally is bound to occur, with many features buried entirely, thus erasing or blurring all but the most radical differences between pre-existing structures.
All this said, if there *were* evidence of an impact present in Alphonsus' wall at this location (congruent depression) that would certainly serve as addditional evidence of the crater nature of this circular formation. It's absence, however, though notable, isn't inexplicable to me. What *is* inexplicable in this case is that anomalous, oddly angled linear ridge/peak out on Alphonsus' floor---which also happens to lie congruent with the circular ridgeform--but aside from being a rim remnant of a pre-existing crater, i can't think of any other more likely explanation for it's presence there? That's what tipped it for me anyway.
Anyway, thanks to Carol for the observation!! --that is something that needed to be looked at and I didn't until she mentioned it. This feature could still be just an optical anomoly. I feel it *probably* is not, but I mean to imply no certainty (which is not even possible I think), just assess probability one way or the other.
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March 3rd, 2013 – Enugu State Governor Sullivan Chime Sick Again; Flown Abroad For Emergency Treatment
The Governor of Enugu state Nigeria, Sullivan Chime who recently revealed he has been diagnosed with a deadly cancer of the nose has been airlifted to an undisclosed hospital outside the country for an emergency medical treatment.
Though the nature of his sickness this time around hasn't been revealed, we learnt the able Governor spent over four weeks at a private hospital in London where he underwent two major cancer related surgeries before returning to Nigeria.
Governor Chime came back into the country few weeks ago from London.
Get well soon Chime!
Join us on Facebook @ https://www.facebook.com/naijagists for latest news updates


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Sellsy offers you 3 payment means for your store: Paypal, Stripe, and Bluepaid.
To use them, the modules must have been enabled in the Store section.
Once this is done, you can now activate them for your store:
Other means of payments will be added and the FAQ article will then be updated.


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Jane has wanted Ethan for years but has never found a way to tell him. With Valentine's Day fast approaching, she decides to seduce him by sending anonymous erotic valentines every Friday until the big day. Then she'll finally reveal her true feelings— and wildest desires.
But when her stationery store is vandalized, it's Ethan who comes to her rescue—and the sparks start flying way ahead of schedule. Now Jane and her erotic alter ego are competing for Ethan's affections— and the results couldn't be hotter.
Check out my review for Hot Mail by Janice Maynard.


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Due to technological advancements, self-testing has become widely accessible to the public. Individuals can opt to have their genome sequenced or their blood tested for markers at a relatively cheap price. These direct-to-consumer services are essentially a commercialization of technologies being marketed to the general masses.
Some genomic giants in the industry include 23andMe and Gene by Gene. Their test kits can be delivered internationally and sampling is performed by the user and sent back for laboratory analysis, thus establishing an accessible and flexible service model. Users can opt to test for specific genes that correspond to a potential disease or learn about disease predisposition, drug responses, or genetic characteristics.
Other companies offer to quantify a range of biomarkers that can potentially predict the early onset of a disease or condition. Their kiosks and laboratories are situated within pharmacies and the blood tests can be performed without a physician's consent. The results are then electronically delivered to a physician or directly to the consumer, and are subject to self-interpretation.
The underlying notion is that such testing may uncover abnormalities that could potentially serve as an early marker of disease. By identifying this pathogenic link at an early, asymptomatic stage, the consumer can possibly take steps to prevent disease later on. However, it is important to keep in mind that due to epigenetics, environmental and other factors a gene sequence is not always reflective of a phenotype. The sequencing only provides minimal information about a possible genetic foundation, yet ambiguous gene expression deems results inconclusive. Likewise, testing for biomarker concentrations in the blood is not necessarily a reflection of a patient's condition. Due to the large variability in individual physiology, there can be ambiguity with self-interpretation. Despite having access to reference ranges/intervals from online sources, many patients are in a poor position to judge their own health. Factors such as lifestyle, time of day, eating patterns, and ethnicity heavily affect results; for these reasons, a physician may be best positioned to analyze results.
Here, we ask 4 individuals about their opinions on various aspects of direct-to-consumer testing.
Do you think whole genome sequencing in 2016 is beneficial in some shape or form to the majority of consumers?
David Grenache: It depends on what one considers beneficial. For some individuals, simply having access to their unique genetic information is itself the benefit, regardless of whether or not it is actionable. For others it's the knowledge of ancestry that accompanies direct-to-consumer genetic testing services that's of value. As with any service or product, the consumer makes the determination regarding value. Why should genetic information, or any laboratory test for that matter, be any different? That said, consumers of sequencing tests must be fully aware of the limitations of whole genome sequencing results and need to be educated about what these data can and cannot reveal about health and health risks.
Michael J. Joyner: No, I believe this is a niche technology best used for research purposes and to investigate rare diseases that are difficult to diagnose or that are "one-offs." To do the latter it will need to be part of a comprehensive rare diseases or clinical genetics evaluation. This sort of testing is already providing causal insights in some but not all cases. Unfortunately, in many cases it does not lead to a beneficial therapeutic intervention but can help families think about future reproductive options and testing. In cases like channelopathies and sudden death in the young, a sort of "genetic purgatory" has emerged where an apparently causal DNA variant in the case is also seen in healthy relatives. Then the question is literally about who does or does not get an implantable defibrillator based on what criteria. For most issues in this area there are no easy answers and the potential for less than ideal unintended consequences and ambiguity is substantial.
Daniel T. Holmes: I think the key phrase in this question is "to the majority of consumers." My position is that presently it is generally not medically beneficial to the majority of consumers but may be useful in specific contexts. Consumers can receive various products from these companies. For example, they can purchase a single nucleotide polymorphism analysis but the clinical inferences one can make from single nucleotide polymorphisms are frequently of little value. How should a consumer respond to, "You have a 7.3% increased risk of disease X"? Accordingly, this type of report has been subject to regulatory limitation in North America due to the ambiguity of available evidence. Consumers can also receive ancestry reports, primarily for personal interest and carrier-status and drug-sensitivity reports, which may have utility in select circumstances. Finally, they can receive reports about certain well defined but medically banal Mendelian traits such as whether their earwax is crusty or slimy (no, I am not kidding).
Rodger Seccombe: While there remains a substantial gap between our current ability to complete vs effectively interpret a whole human genome sequence, we are already seeing the benefits of whole genome sequencing as a tool to help diagnose and treat rare diseases in symptomatic individuals, such as in England's 100000 Genomes Project. The average curious consumer might also benefit in some ways. However, for most individuals, the insights gained would not justify the expense of completing a whole sequence.
Given the limitations of our current genomic knowledge base, the majority of whole genome sequencing consumers would not receive much "actionable" information beyond the basic pharmacogenomic and carrier status reporting that can be obtained from less costly genotyping services. That said, however, new discoveries are being made by comparing entire genomes. So on some level we are all benefiting from those individuals who are completing and agreeing to share their whole genome sequences for research.
How reflective of a patient's health are sequencing and blood testing results?
David Grenache: It depends on the gene associated with the sequence or the particular analyte being evaluated in the blood test. It's well known that many DNA polymorphisms have no effect on one's health while others are very predictive of disease. The result of any blood test represents a small snapshot in time captured at the moment of phlebotomy. No single test is capable of being reflective of "health" any more than a single word can reflect the plot story of a novel.
Michael J. Joyner: For the average person the results are likely to be of marginal or no benefit and difficult to put into context. A large issue here is the so-called incidentalome, which would reveal the presence of "pathologic" variants in individuals who are phenotypically normal.
Daniel T. Holmes: With respect to sequencing, in certain contexts, for example where there is a yet undiagnosed or subclinical monogenic disorder, the data could be very useful and reflective of the patient's current or future health. But this scenario would certainly represent the exception and not the rule.
The same is true of blood testing. Untargeted use of blood tests is more likely to lead to confusion and waste because of the Bayesian principle that as the disease prevalence approaches 0, the positive predictive value of the test approaches 0. This means that performing a nonindicated test leads to diagnostic confusion, further testing, and referrals.
If we factor in the principle that most reference intervals are based on the central 95%, then the probability that at least one test falls outside its reference interval by chance alone is 1–0.95n, when n tests are performed. This probability exceeds 50% for 14 or more tests.
There is also an implicit assumption that results inside the reference interval imply health and results outside the reference interval imply pathology. However, results outside the reference interval don't always imply pathology and there can be "inappropriately normal" results that are highly pathological, e.g., a TSH (thyroid-stimulating hormone) of 2.5 mIU/L that looks ostensibly normal would be indicative of secondary hypothyroidism if the free thyroxine were 0.60 ng/dL (6.4 pmol/L).
Rodger Seccombe: We know that for certain disease states, some genetic mutations and serum biomarkers (particularly once confirmed) can be highly reflective of a patient's current health or even diagnostic in and of themselves. This is possible, in part, due to extensive research and standardization of laboratory testing for certain analytes, such as hemoglobin A1c, creatinine/eGFR (estimated glomerular filtration rate), and lipids. Other results and genetic findings are not as well known, standardized, or uniquely predictive. However, they can still be important indicators when evaluated as a group and in the context of a patient's history and symptoms.
As technology enables more health- and lifestyle-related data points to be made accessible and analyzed in aggregate over time, the current and likely future state of a patient's health will become more certain. Until then, genomic sequencing and blood test results will reveal only part of the story.
What is your opinion on commercializing genome/exome sequencing to the masses? Is the motivation mainly for profit?
David Grenache: What motivates any individual to launch a company or provide a service? In an economic system based on capitalism, profiting from the sale of a product is necessary but that doesn't mean it's the main motivator. One could ask the same question of hospitals and healthcare delivery systems that often make huge profits from laboratory services because their charges are marked-up greatly, vary widely, and are not transparent. I believe we are at the threshold of a new era in medicine, one in which patients are growing much more engaged in how decisions are made regarding their care and are demanding access to information that, until recently, has not been easily available to them. Now that information is becoming increasingly available and at prices that are simultaneously transparent and affordable.
Michael J. Joyner: I believe some of the motivation is for profit. I also believe that this is a bit of a Trojan horse effort to get health information and DNA from a large sample in an effort to generate "big data" and look for rare variants that might give insights into potentially "druggable" or therapeutic targets. The goal at some level is to find the next proprotein convertase subtilisin/kexin type 9–like target.
Daniel T. Holmes: This appears a profit-motivated business directed at the well heeled, worried, and curious well. If this were about the good of humankind, we would expect philanthropic organizations working to bring these services to the underprivileged of the world, which they are not doing.
Rodger Seccombe: For-profit companies have been making significant investments to provide genomic services to the public, ultimately to create and return value to their shareholders. While there's a clear profit motive, these efforts also help fuel advancements in the underlying technology and enable new scientific discoveries.
As demand grows for these services, we will need to ensure the necessary safeguards are in place to protect the public's genetic information. For example, enacting new legislation, such as proposed Bill S-201 in Canada, to prohibit and prevent discrimination from insurance companies, employers, or others based on genetic characteristics.
What are the pros and cons of making self-testing accessible at pharmacies without a physician's oversight?
David Grenache: I see several benefits. Patients are becoming active consumers of medical information and are becoming more educated about their health. As such, they rightfully demand more control and access to personal health information. There are known benefits of patient self-testing, particularly when it comes to the management of chronic diseases like diabetes. Cost is always a concern, even more so for patients without health insurance or for those with high deductible insurance plans. Direct-to-consumer laboratory testing companies have price transparency and offer their services at a cost that is usually considerably lower than what would be charged in a hospital or reference clinical laboratory. One disadvantage is that easy and affordable access to laboratory tests could prompt some patients to over indulge, with the unintended consequence of initiating a cascade of events due to the inevitable false positive result. The disadvantage I hear voiced most frequently is that patients won't understand the results or will misinterpret them. I don't completely disagree with this but I do think that patient's who are engaged enough to use these services are motivated to learn what tests to consider and understand what test results mean. There is a great opportunity here for clinical laboratory professionals to be leaders in this patient education, which would have the added advantage of raising public awareness of the role we play in healthcare delivery.
Michael J. Joyner: I see no pros. I see only issues related to a reduction in quality and things being interpreted out of context.
Daniel T. Holmes: Are there pros? I suppose if someone checked their lipids or fasting blood glucose and obtained increased results, this might spur them to see their physician. But they could get this self-same testing (essentially) free-of-charge though the medical system in Canada and through their usual insured care in the United States.
I see a number of cons, the first being device performance. Neither pharmacists nor consumers have a means to scientifically or clinically validate the performance of any analytical device, point-of-care or otherwise. The device's performance is evaluated not on accuracy and imprecision, but on its usability. The consequence is that a device can be underperforming without consumer or pharmacist's knowledge—even for an extended period—as illustrated by the regulatory and media reports on Theranos and its Edison device. When physicians are part of the equation, in both the laboratory and clinical care contexts, they can vet the data both scientifically and clinically, ensuring the consumers' safety and cost value.
Local to my university, HealthTab is offering direct-to-patient testing for some tests on the Piccolo Xpress device. We have one of these instruments at our hospital. While some analytes compare reasonably to core analyzers, others have very problematic bias and/or correlation problems.
The second con relates to regulatory and quality issues. Are direct-to-consumer laboratories required to conform to accreditation standards? Are they required to submit to an external quality assessment program?
Other quality-related issues exist. What do direct-to-consumer laboratories do with critical values? Who is medically and legally responsible if an abnormal result goes unaddressed and there are medical consequences?
The third con relates to economics. If the patient gets an abnormal result by chance alone and then self-refers to their physician, who bears the cost of the inappropriate referral? At present, it is the insurer.
Rodger Seccombe: The most important benefit we have seen with HealthTab is the ability to better engage individuals in their own healthcare, particularly in the case of chronic disease prevention and management. Pharmacists are often more accessible than physicians and can support patients to reach the targets laid out by their doctor or flag potential risks sooner. Direct testing can also provide an "educational moment" where pharmacists can reinforce the importance of a healthy living and/or medication adherence at a time when patients are more receptive.
On the con side, people often cite "creating the worried well." But studies show that most of us overestimate just how healthy we actually are. So for every person who is needlessly concerned by a test result, there are far more who are in fact unaware of their health risks and should be following-up with their doctors and/or taking preventive action.
Can direct-to-consumer services destabilize a patient-physician relationship?
David Grenache: I would hope not. Direct to consumer testing has been around in some form or another for decades (e.g., home glucose monitoring, pregnancy testing) and I don't see that it has had destabilizing effects. What's happened more recently is simply that the test menu available to patients has expanded beyond that provided by over-the-counter tests. It's easy to see how a patient could come to a doctor appointment with a laboratory report of results from tests they had performed and ask questions about what the result might mean. If that destabilizes their relationship then it's time to find another, more secure, physician. This issue is not going to go away and, with time, there will be more, increasingly mobile, ways in which patients will engage in self-testing. Medicine has a long and strong tendency towards paternalism and clinicians who are resistant toward empowered and knowledgeable patients are going to find they have a hard road ahead of them.
Michael J. Joyner: Not in a major way, there are many forms of information that are already changing this relationship and this is just one piece of technology that can be misapplied or misinterpreted.
Daniel T. Holmes: Good patient care is ongoing relationship-based patient care. Sometimes in laboratory medicine, we are so focused on numbers that we almost forget we are caring for people, not specimens. Laboratory testing happens to be something that can be commoditized but consumer-driven laboratory testing does not look at the patient's overall appearance and check their vital signs. It does not ask about family history, or the reason for the visit. It does not palpate the submandibular lymph nodes or the thyroid. It does not listen for a murmur. It does not feel for abdominal or breast masses. Most importantly it does not ask, "How are things going with your work?" or "Last time you were sad about your mom's passing. How are you coping with that?" And, of course, it does not order and interpret the tests in a clinically appropriate manner.
Rodger Seccombe: Technology is turning the patient–physician relationship on its head. This has been happening since the dawn of the Internet. Most patients these days (particularly the younger generation) will search the web first before seeing their doctor. So the physician is no longer the 'gate keeper' of health information but rather an expert advisor.
Direct access testing is really just an extension of this trend towards providing patients with more information and insights about their own bodies and health. Though not without challenges, this is ultimately positive because it means patients are more informed and engaged when they visit their doctors or any other heath professional for that matter. It becomes more of a partnership.
Do you believe that the smart phone will become the repository of our health information for direct-to-consumer testing? How could a smartphone become a patient-operated medical device?
David Grenache: Absolutely! In fact, I'd argue that it's well on its way to becoming just that. We already save an incredible amount of personal and professional data on mobile devices, and in the Cloud health information is just one more piece. The smartphone is at the center of digital health wheel and patients are already generating and/or uploading their personal health data onto them, which can then be analyzed and graphically displayed on it. Equally important is the connectivity and data-sharing aspects that the smartphone enables. Combining small microfluidic devices with the processing power and display features of the smartphone makes smartphones as patient-operated medical devices a future certainty. Indeed, several private and public companies are already developing such applications.
Michael J. Joyner: Too soon to tell, and at least so far many wearables and apps have fallen short. The wearables have been plagued by imprecision and inaccuracy and the so-called Quitbit effect. Like gene testing, it is unclear just how motivating they are in the long run to get people to change behaviors. By contrast, text messages as reminders to take drugs, eat less, walk more might be useful. But this is a very low concept use of technology.
Daniel T. Holmes: I think it is feasible that we would all carry our medical record on a smart phone/watch in the future but I don't see this as an idea that would garner too much interest in the near term except possibly as a pilot project for a cohort of early technology-adopters. However, the smartphone is in essence a portable computer with ports for attachment of peripheral devices. This makes the smartphone an optimal tool to which one could attach a detection device of any sort—optical, audio, thermal, ultrasound, or biochemical. The computing power of a smart phone far exceeds what is required for data reduction for blood testing and this is an area of active engineering development. Naturally, there are technical challenges associated with the use of whole blood and a small sample volume that would need to be overcome, but I imagine that this kind of technology is inevitable and could be extremely beneficial in developing countries.
Rodger Seccombe: Absolutely. The smart phone along with connected medical and health tracking peripherals will be the most effective solution for securely collecting, storing and sharing data. Using the patient-owned smart phone as the hub will also solve the many challenges around consent and integration across disparate electronic medical and patient health record systems, leading to better continuity of care.
As we learn more from data mining genetic, health, and lifestyle information, there will be new advanced algorithms developed to enable earlier diagnosing, as well as personalized treatment and prevention strategies available directly from the smart phone. Advancements in point-of-care technology should also allow more data to be collected and analyzed in real time without the need to visit a laboratory, particularly for less complex tests such as glucose or lipids.
Will consumer testing become a privilege of rich people?
David Grenache: I don't believe so. Consumer testing has been available for many years and, over time, not only have technologies improved but costs have come down. One only needs to look at the test menus of the many laboratories that currently offer direct-to-consumer testing to see that the costs are not out of reach for most and are certainly not affordable only by the wealthy.
Michael J. Joyner: It will become a curse of the well off. They will get the extra testing, get hard to interpret risk data, demand extra interventions, and suffer the iatrogenic consequences of over testing. This is of course a great irony.
Daniel T. Holmes: I think consumer-based testing is already targeting the wealthy. In Canada, despite the fact that medically necessary healthcare is ubiquitously covered by the government-run system, private user-pay wellness clinics offering ancillary services have sprung up along with laboratories catering to this same clientele. At present, this is the face of Canadian consumer-oriented testing and its advertising is clearly geared to appeal to the financially privileged.
However, the business principle of the smart phone industry is to create relatively inexpensive apps peripherals that offer health metrics—most notably those measuring movement as a surrogate for caloric expenditure. The addition of an inexpensive biochemical sensor to the smartphone does not seem a far-fetched notion and this for-the-masses mentality may democratize the consumer-testing industry and prevent it from becoming a privilege of the elite.
Rodger Seccombe: There's no doubt that the early adopters of new consumer testing technologies will end up paying the most. Fortunately, with the help of Moore's law we've seen how quickly prices can fall for the underlying technology, ultimately making these once extravagant products and services accessible to the masses. For example, one of the first direct-to-consumer whole genome sequencing services was priced at $350000 in 2007. Today's price: approximately $2500, and likely less than $100 by 2020.
In certain cases, a direct-to-consumer testing model could result in significant healthcare savings and should be considered as the new "standard" approach. For example, providing point-of-care lipid testing in pharmacies for individuals diagnosed or at risk for heart disease or diabetes. By involving the pharmacist and engaging the patient, we know that we can enhance compliance to treatment, trigger lifestyle modifications and reduce unnecessary physician office visits.
In 10–15 years from now, what do you see coming in terms of technology targeted to self-diagnostics or totally noninvasive diagnostics?
David Grenache: Several technologies are coming together to permit a paradigm shift in self-diagnostics. The capabilities of the smartphone, as a conduit of health information, will continue to improve in ways that allow patients to diagnose disease. Things like virtual health assistant apps that permit users to type or speak symptoms and/or upload physical metrics and images will then be queried against vast databases to provide likely diagnoses. Additionally, the application of wearable and connected sensors (often referred to as the Internet of Things) to collect and share health data can be used not only to manage chronic disease but perhaps diagnose illness in early stages. Advancements in microfluidics will allow the production of small, self-contained laboratories that will interface with a smartphone to analyze and interpret results. This isn't science fiction; it's happening now. If you haven't started paying attention to the Qualcomm Tricorder XPRIZE, a 10 million dollar inducement prize contest offered to the team that can produce an automatic noninvasive health diagnostics device weighing <5 pounds that can diagnose patients better or equal to a physician, you should.
Michael J. Joyner: The Holy Grail is noninvasive blood glucose monitoring, tracking and adjustment of insulin administration rates. This has been the Holy Grail since before I started in medical school in 1982. It will be interesting to see if they get there.
Daniel T. Holmes: I think there will be a proliferation of machine learning ("deep learning") or crowd-based online tools designed for the submission of symptoms and clinical/biochemical/radiological data that will provide a differential diagnosis. Online tools like this currently exist and the big technology and information players, Apple, IBM, Google, and Microsoft, are all interested in deep-learning applications to medical diagnostics. All of these tools greatly appeal to an individual for whom travel to see a physician is undesired, inconvenient or impractical. This kind of tool could also represent a decision-support device to paramedical personnel. But algorithms lack the discernment and judgment so critical to medical decision-making. I find the investor-enthusiasm misplaced at the present time.
Although limited to cortisol in my part of the world, salivary diagnostics is an extremely active area of research in the arenas of genomics, transcriptomics, proteomics, metabolomics, and the microbiota using every imaginable detection technique. This will be interesting to watch unfold and will present many regulatory challenges.
In terms of near-term noninvasive in vivo biosensors, a number of companies are working to monitor glucose in tears as part of the management of diabetes mellitus, but biosensors of this type have been extended to lactate monitoring and should see other applications. Similar mouthguard-style biosensors have been made for salivary glucose, lactate, phosphate and other targets.
Rodger Seccombe: I think point-of-care technology will become increasingly sophisticated and advances in microfluidics will bring lab-on-a-chip technology closer to the consumer, where it would ultimately be integrated with smart phones. We'll likely also see the next generation of wearable devices capable of measuring and tracking much more biometric data, such as electrolytes, sodium, lactate, proteins, and other markers through sweat analysis. Eventually, we'll see even tighter integrations with health tracking technology, such as Google's smart contact lens or implantable continuous glucose monitoring systems.
The most powerful advancements, however, will come from improved decisions and diagnostics being made with the help of big data analytics and artificial intelligence. For example, IBM's Watson is already being used to make personalized cancer care decisions in US and Canadian hospitals. Eventually this type of intelligence will become readily accessible and help everyone become better educated and engaged in their own health.
Author Contributions: All authors confirmed they have contributed to the intellectual content of this paper and have met the following 3 requirements: (a) significant contributions to the conception and design, acquisition of data, or analysis and interpretation of data; (b) drafting or revising the article for intellectual content; and (c) final approval of the published article.
Authors' Disclosures or Potential Conflicts of Interest: Upon manuscript submission, all authors completed the author disclosure form. Disclosures and/or potential conflicts of interest:
Employment or Leadership: E.P. Diamandis, Clinical Chemistry, AACC; R. Seccombe, HealthTab Inc.
Consultant or Advisory Role: E.P. Diamandis, Sanis Biomedical, Abbott Diagnostics, Berg Diagnostics, and bioMerieux.
Stock Ownership: R. Seccombe, HealthTab Inc.
Honoraria: None declared.
Research Funding: None declared.
Expert Testimony: None declared.
Patents: None declared.
- Received for publication May 3, 2016.
- Accepted for publication June 30, 2016.
- © 2016 American Association for Clinical Chemistry


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Models We Love – Rhino
Rhinoceros 3D, known as Rhino is quite an interesting CAD tool. Widely favoured by Product Designers, Architects and Automotive Designers because of its 'free-form non-uniform rational B-spline (NURBS) modeling', allowing the creation of curvilinear designs easy as pie. There are also hundreds of third-party plugins. At the beginning Rhino was distributed freely, allowing a community to spring up to help de-bug and improve newer versions. Sounds familiar, no?
Here is a VTOL Concept by Sönke Dierks, completee with a "turbine in the bottom of the fuselage driving electric motors in the (udf) fan-nacelles, thrust vectoring nozzle on the tip of the tail. fan nacelles 90 degrees tiltable."
Read the rest of this entry »


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News archive
FLYBE COMMENT Re Government Announcement on Airport Expansion
Flybe's CEO Saad Hammad comments on the Government's announcement on Airport Expansion
11th December 2015
"Despite acknowledging the need for increased airport capacity in the South East, the Government has once again delayed making a real decision. Flybe therefore reiterates its call on the Government to review its refusal to open up RAF Northolt to a limited number of domestic commercial flights which would deliver enhanced regional connectivity to London and Heathrow Airport as well as additional money for both the RAF & HM Treasury and a reduction in noise levels for local residents.
"Given that any new runway will not be built for at least another 10 years, it is surely now time that the hugely underused national asset at Northolt is opened up to 300,000 passengers rather than being just for a privileged few in executive jets."
Notes to Editors
- RAF Northolt is currently used by private executive jets, VIP's and RAF transport. Two-thirds of aircraft movements at Northolt are private commercial and less than 30% by RAF aircraft.
- Flybe submitted a proposal to the Ministry of Defence for opening-up RAF Northolt to new domestic routes and on 30 November 2015 Flybe issued a call on the Government to review the Ministry of Defence's refusal to give consideration to opening up RAF Northolt. The full release is available here: http://www.flybe.com/corporate/media/news/1511/30.htm
- Flybe's quiet turbo-prop aircraft are quieter than many of the private jets that currently use RAF Northolt.
Issued by the Flybe press office:T: 0845 675 0681 E: [email protected]


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Industrial Bikes that Get the Job Done (Slideshow)
Photo: longjohn.org
Work Bikes, Freight Bicycles, Cargo Trikes, Utility Bicycles, Industrial Bikes -- or whatever you want to call them -- have been been with us for almost as long as the original safety bicycle itself. Though not conceived for recreation or racing, they have often been conscripted into those rolls too. But primarily their role has been utilitarian. Moving materials, goods, animals and people from place to place. Human propelled mules. Pedal powered trucks.
This visual teaser showcases the capabilities of these uber-efficient beasts of burden.
• Bicycle Cargo. Chapter 1: Racks And Bags
• Bicycle Cargo. Chapter 2: Bike Trailers
• Bicycle Cargo. Chapter 3: Extended Frame Bikes
• Bicycle Cargo: Chapter 4: Cargo Bike Business (A - L)
• Bicycle Cargo: Chapter 4: 24 Cargo Bike Businesses (M to Z)
• 13 Quadracycles - Four Wheel Bike Round-up
• Tricycle Round-up


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Cookies - a brief explanation
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Building a habit out of ivies and orange flowers. Leaking away the time of possession, seeing without haste. The music has no purpose, neither the candles, neither the water. Words paired together too often become anathema. A revolt of the inner mind is underway. It can be stopped with judgement, with caution, with pardon, and if that is the case then belief is uncertain.
I. Haunting the Streets
Haunting the streets when the ghosts have all been laid to rest. Several methods of joy suggested, antagonistic to the idea of proving anything. Everything in the world can be stolen; not everything can be returned. It becomes a collection of strange aphorisms with no value, it becomes a stage upon which the emotions can play. A flat plain of existence, a sharp pain in the kidneys, an overactive mistake. What these things have in common is their erotic nature, hidden beneath layers of tongues. Absolutely: no coherence, not even with itself. And there is an inherent thrill with this, like pushing away clean sheets and finding a chasm.
Then there were the ideas of sex as a mutual belief in the greater good. There were ideas that flowers were metaphors for illusion. There were ideas that did not matter and there were ideas that had an impact not dissimilar to a catechism. Repetition under fluorescent light: at night the gazes wander, they trace sharp lines and leave the curves alone. Again, a powerful impossibility. Careful structuring is the enemy of lips, the enemy of partition. Another method of joy, partial and unfulfilling, still the longest road to travel. Better to undo the zippers down the arms and the buttons at the base of the spine, better to leave the clasps alone, better to do nothing well than to do nothing at all.
A turning point is concocted: the potion boils over on the stove, smelling of dust and lavender. Thoughts are removed from internal organs, displaced. It is this way and this way only; to dispute is to join the ranks of heretics and jesters, who in their mocking make it all come to fruition. Dance and laugh and cry. Dance while underneath dying, laugh with bells, cry in a graceful motion. Theses things can all be stolen but they cannot be returned, and if this is a joyful thought then remember that an allotment of joy can be turned around only once. After that, senses must be remade in a new image, the smell of skin will be real, and touch will be silently masked but still vibrant and whole.
II. End of a Richly Imagined However
End of a richly imagined however: now the reality of stubbornness sets in and she is nowhere to be seen, only heard. Her voices float somewhere above, as in the atmosphere, the stratosphere. Presume that her long lonesome body is like an uneven picture. Presume that sometimes she likes to be held too tightly, her lips wrapped around the engine of her sorrow. If only these diametrics could come together; if only these disparities could be wrapped in the blanket of articulation.
What gives is the hardness and the softness is unyielding. What comes undone are the long yards of hope with which legs are untied and economies revamped. And if she is in space and beyond all reach then it is all lost and the images grow dim; still they were only imagined to begin with and therefore cannot follow, only precede. Time lost and time regained. She is there in the shell, the dark home. What gives, gives in; what continues is the sound.
And desire: desire in her is desire in the saturated air, unpredictable. An oil well burning the reserves of future humans, a seagull at the pier without food, a collection of old postcards from a forgotten journey. Now it could be understood that fingers interlace of their own accord but bodies do not come together without interference. And now it could be understood that the diametrics have come together, the long yards of hope have come unraveled, time is lost, thought regained.
III. A New Type of Emptiness Is Needed
A new type of emptiness is needed. There: it has been said, and now the wars can begin. A tension is produced between the written word and its unknown components. Some call these chains and some call them elongations, and it is unclear whether one or the other serves an end and therefore the call for a new kind or new type, therefore the foam of words, the collisions. Whatever it is, it will be unconditional when it arrives in brown paper wrapping and with no note.
It is asked what comes between two things when they cannot seem to reach a mutual condition of being and the answer is always the same and is always ignored. Imperatives are issued, inconstant revival of this thing heard in the deeper resonant levels of mind. When it rises it causes a fear and the fear breeds in the abdominal cavity and then goes away. In search of a new subject: a new story: a new layout of the internal dynamics of catharsis and release.
Here explodes the last thing. Defiance can take place in new forms; power remains constant. Contentment: the new emptiness is the old emptiness and in the return is has been discovered that there is no need for newness, only parsimony in what is already there, what always has been there, and what always will be there.
IV. Yelling Spitting
Yelling, spitting, an act of mimicry. Here in corners of belief dark and unknown, a man in robes comes calling and then retreats. His message is garbled and deciphered with the help of an almanac and several old maps: speak, speak, and then listen. The boats listing on air will not return, the cars will swerve to miss the flattened bodies of pigeons. Darkly he goes, unheard, and nothing is changed. Later in the year a spell will lie across the town like a bard and no one will cross streets without looking. If there is a reason in that it has yet to be determined. If there is reason at all it has yet to be uncovered. But it could happen.
When the writing was like this, the emotions were decorated with illumination. The painstaking labor it took to erect a building without windows, the light let in through holes punched through concrete and chicken wire. The heart vibrates and small circles expand from its core. The body is clogged. It will come clean with a fast of berries and nuts and ruptures will result. Cleaving to a person like this is uneven; poetry is the language of frogs filtered through a mesh screen, boiled to an essence, and poured across the floor.
Here the man in robes who is young is at a disadvantage. He sees with his spinal cord. Everything is a challenge but the real moments of triumph are small ones, neglected ones, things like lighting the burner on the stove, things like having a cup of tea without the phone ringing. Sometimes when these small things pass they leave a small space in the mind, the kind of space that can be filled years later, when the reconstruction of a damaged soul is underway and the frogs are singing again and even those objects that have been misplaced are once again comfortable and sated.
V. Carrying the Process to Its Conclusion
Carrying the process to its conclusion. Here in humid blueness the air clings to the horizon like a bad sweater. Without this the silver is tarnished and the plants grow weak, but also persevere. Where there is no perseverance there is no continuation and clutter is one result: also disorientation, nausea, morning erections. A conditional statement has the power of suggestion. Watches are broken and vertical lines transverse the screens of waiting minds. In search of: however, a kindness, a smile that reveals teeth. Here it is, clinging, lifelike, in need of motive, in need of structure. Then, declined.
But conclusion is the point and declension is not conclusion. So the humidity changes color, goes to ground, becomes new again. So watches are unbroken but not repaired, in need of faces, no teeth in their unsmiling displays. The urgency of it is misplaced, a sin. Either it is lost or it is present in an unfamiliar way. Wordplay becomes a dangerous end because there is no conclusion in it, only open doors, heart surgery, thin air. Breathing takes its toll and breath is wasted, leaving time, leaving openings in dark corners full of lint and hair and the bodies of flies.
Then the thing to do becomes put on the best suit and the worst tie and go out in public and make small noises with feet, ambiguous gestures with hands. The thing to do becomes retaining interest without speaking words. The thing to do becomes truculent, a truism, a transition. But the plants are growing, comes the response. And the vertical lines are gone. True, true. Only one thing can be said and it must be said again and again for it to become real, but there is a danger in this, and an anger. The dark corners are found, explored, and they contain lint and emotions and the dead bodies of flies.


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