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"The most important things are the hardest things to say. They are the things you get ashamed of, because words diminish them - words shrink things that seemed limitless when they were in your head to no more than living size when they're brought out. But it's more than that, isn't it? The most important things lie too close to wherever your secret heart is buried, like landmarks to a treasure your enemies would love to steal. And you may make revelations that cost you dearly only to have people look at you in a funny way, not understanding what you've said at all, or why you thought it was so important that you almost cried while you were saying it. That's the worst, I think. When the secret stays locked within not for want of a teller but for want of an understanding ear." - Stephen King
"The world is made of stories, not atoms." - Muriel Rukeyser
Screenwriting gurus both here and overseas have long "made their bacon" preaching the primacy of structure and formulistic principles. "Three-act structure", "inciting incidents", major & minor turning points" - are part of the lingua franca of those "in the know", as well as their eager disciples, and others desirous of mastering the difficult art of cinematic storytelling.
To be sure, the analysis of structure as presented by McKee and others has its value, but its usefulness is limited, and only really becomes apparent AFTER the storyteller has written a good part of the script. A slavish and single-minded adherence to structure in the hope that it will somehow allow one to conjure up a compelling and enduring film script is as likely as creating a masterpiece with a "paint-by-numbers" set. Though having said that I realise there will be some who will take it as a challenge, and if you happen to be one of them then all I can say is do your worst!
The preeminence of STORY and the conventional wisdom that "story is KING!" confuses ends and means. Story certainly matters in the end, but how do we - as prospective storytellers - actually find it? Where does it come from? And how might we give ourselves the best chance of intersecting with it? How does the dramatic, screen storyteller arrive at that state of being where story-as-intellectualisation gives way to a subtler and more profound recognition that stories are as fundamental to one's life and well being as air and water.
Drama is principally a present-ation of the emotional and intellectual dimensions of the cause and effect of desire and its frustration. What a character wants (desires) and does (as a result of that desire – or frustration) produces consequences. The character either takes responsibility for the consequences or does not, but his reaction produces further consequences that impact on him and on the other characters and their world, thus creating more consequences. The law of cause and effect (karma) is the stomping ground of drama (including tragedy and comedy).
Likewise, when a story is told, it too has consequences. Perhaps it will cause people to feel something very deeply, or fill them with fear, or cause them to reflect upon some idea, or maybe simply put them to sleep. Just as a good dramatic character is responsible for his actions, so too are the best storytellers responsible for their stories. But here, "responsibility" does not so much signify obligation as the ability to respond.
Successful and satisfying dramatic stories are not created by chance or out of thin air. An essential component (without which all other components languish) is the personal engagement and commitment of the storytellers themselves to the story they are finding.
Metaphorically, it is not so much an affair of craft as an affair of "up-bringing" - or, rather, lifting the lid of one's unconscious, even if only a squeak.
What I am talking about is engagement – an engagement that is driven and inspired by openness to story. In other words, the journey to find the story becomes part of the storytellers' own, personal journey towards discovering what that story means, emotionally, to the storyteller. It is, indeed, an act of self-discovery.
The attitudes that allow this discovery to happen and the collaborative synergy those attitudes produce take time to evolve, but once underway, the evolution is greatly assisted and encouraged when all members of the storytelling enterprise commit to a frank and respectful dialogue concerning their most intimate understanding of and connection with the story the team is seeking.
One could do worse than ask oneself: what is the story that possesses my being? What myth of self (-deception) is being played out in my life by the same characters, in countless guises, in a thousand various scenarios wherever I go?
The question implies the notion that there is an essential dramatic idea at the heart of each individual's odyssey. But is this possible? Is there an underlying theme operating in every life? Is every individual possessed, either consciously or unconsciously, by his or her own singular and personal drama?
I believe the answer is, most assuredly, yes; and that in facing and acknowledging the essential characteristics of our own particular drama (or dramas) we can more honestly and fruitfully find, explore and understand how every story we seek to tell or contribute to (in some meaningful way) is in some way connected to us - to our hopes and to our anxieties.
If this is so, then the collaborative enterprise of finding the story that resonates with one's soul and with all of the souls that are seeking it - the greatest enemy is fear and the deceptions (the ignore-ances) that it encourages.
The playwright, Arthur Miller, has suggested that, essentially, drama is always about a fear of falling – the primal fear. Certainly, the first story in Western culture is a dramatisation of this fundamental fact of existence – the so-called Fall of Man. But what is the essence of the Fall? What brings it about, and what does it tell us about the nature of human and non-human reality? What does it tell us about HOW we should live our lives, and why and for what? Any story that prompts us to ask these sorts of questions is a story worthy of our attention.
The fall of Adam and Eve is a story founded on the idea of power and deception. Here, deception must be understood as being synonymous with evil. It might come as a surprise to some, but most of the Old Testament is composed of stories that explore the nature and consequences of deception, which is another way of saying the Old Testament provides a narrative investigation of the nature of good and evil, which includes its consequences.
In the Adam and Eve story, the principal deceiver, at least in the beginning, is the Serpent, who has promised Eve that by eating of the fruit of the tree of the knowledge of good and evil she can make herself like God. In her freedom, she chooses to eat, and afterwards, persuades her consort to do the same. They have been given the freedom to do anything they like, except eat the fruit of this tree, but freedom is meaningless unless one also has the power to choose NOT to be free. And herein lies the God-like irony, the incompatible addition (to freedom) that aborts through method (blame) and fear and guilt (anxiety) the very power Adam and Eve sought to achieve. Instead of becoming like God, they encourage God's wrath.
When Adam is confronted by this anger and by the question (Why did you eat the fruit?) he blames Eve, and in so doing creates the first method (for escaping response-ability for one's actions); likewise, when Eve is asked, she blames the Serpent, compounding the lie and avoiding the fact that it was her own desire to be God-like that led her to be tempted in the first place. 1
Deception informs every tragedy. The protagonist, himself, operates under a deception, a deception that he, himself, has helped to create and is invariably involved in perpetrating.
But deception also lies at the heart of all drama, including dramatic comedy. In comedy, the deception points out the absurdity of human life; in tragedy it underscores its pathos.
Every drama begins with a fall, or a fear of falling: falling out of a relationship, or out of a job, or out of society, or out of one's life, or, existentially, out of meaning itself. It is this fear of falling that is expressed in the four anxieties that form the basis of dramatic action, as well as the protagonist's impetus to re-establish some form of healing or rectitude. 2
Fear and falling, frustration and deception and the desire for truth and healing – this is the stuff out of which stories are made. The courage to confront one's fears through acts of faith (in one's characters and in oneself) is integral to the finding of the story. It is, indeed, such courage that makes the difference between a birth and an abortion. The courage to accompany one's character on his/her journey is bought with the pain and anxiety one has endured and continues to endure in the act of grappling with the unsolved and seemingly unresolvable. One earns the experience, one buys the wisdom, one takes what one needs for oneself and one's characters) and one pays for it. In this way, collaboratively – in one's interactions with one's collaborators (including one's characters) one will be continually nourished and transformed by those inner stories without which there is no story at all.
1 Interestingly, in the image of Jesus hanging on the Cross we find the symbolic fulfilment of the Garden of Eden story. The Serpent in his tree is now transformed into Christ on the Cross, - the being who takes all the blame, and who, in so doing, exemplifies the saving grace of the Christ principle (Love).
2 The anxiety of guilt, the anxiety of doubt, the anxiety of death and the anxiety of meaninglessness.


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Check us out ... and then tell us what you think.
To whom on earth should God entrust His songs?
Choosing the Wide Road or the Narrow Way
Are you sure you want to sign that record deal?
Impacting the world for Christ, from home.
WorshipOfHeaven.com (i.e. "Worship of Heaven") is a new site, and although it's fully-functional,
we want to make things better; would you help us?
We'd like to get some constructive feedback from those who would like to see this revolution take off.
In order to do that, we're looking for some "Early Adopters".
As an Early Adopter, you'd give the site a workout:
Understand that if you feel uneasy about uploading your own
Songs to the site, you can specify a "Grace Period" for your Songs of
up to 30 days at the time you upload them. During the Grace Period, you
have the option of revoking your Song(s) from site's Song Collection
and completely geting out from any kind of legal committments to the site.
It's like a 30-day
no-questions-asked "return policy" at a store. If you want to exercise this option, be sure
to specify a "Grace Period" of greater than 0 Days on the "Upload"
page, which you'll fill out when uploading the Song(s). Later, if you do
decide to revoke
your Song(s), you can do so via the "Manage" web page (you'll need to be logged
in to see the menu items for these pages).
If you've got even a "possible"
interest in sharing your Songs and/or using others' Songs, then by all means,
consider helping us out. Your early input can help to shape the future of Worship of Heaven.
You're making no committment whatsoever by taking up the role as a Early Adopter.
We're not going to hound you down - just an occasional email.
Furthermore, if you decide you want out, no problem - just say the word, and it's over.
So, how do you sign up for being a Early Adopter? Well, there's no
"sign up" procedure. Rather, if you want to do it, just start right now, right where you're
at. But please let us know if you
decide to do it, would you?
Whether or not you want to be a Early Adopter,
at least consider getting on our email list. We won't SPAM you, and we won't share your information with
others, either. Rather, we'll let you know how we're progressing towards the Launch date and when we actually do Launch.
You can get off of the email list at any time by just telling us you want out.
Here's how to get on our email list:
Create a Login to Worship of Heaven.
Thanks and take care!

subset: commoncrawl


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Monday, March 28, 2016
Istanbul Turkey Day 1.
Terry's niece Alison Brown works for the United States State Department and was stationed in Istanbul, Turkey. Istanbul is an exciting highly populated city that straddles Europe and Asia across the Bosphorus Strait. The Old City reflects cultural influences of the many empires that once ruled here. In the Sultanahmet district, the open-air, Roman-era Hippodrome was for centuries the site of chariot races, and Egyptian obelisks remain. This is a city I would love to live in. There is so much history and culture that needs to be sketched.
Just getting from the airport, to Alison's high rise apartment was an adventure. Once the taxi got off the highways, which were lavishly decorated with thousands of Daffodils, the side streets started snaking up hills. The streets get very narrow with cars are parked on both besides of the street . Every block becomes a game of dare as drivers face off for the narrow passage in opposite directions. Alison's apartment building had guards at the driveway entrance with steel stanchions that could lower into the pavement when a car is cleared. One window of Alison's apartment looked like it had been hit by a bullet causing a hairline crack. Alison didn't think much of it.
Terry played with Louie, Allison's French Bulldog, as I did this sketch. Afterward, we explored the area to find a restaurant. Not knowing the language, we just pointed at item on the menu. Turkey never let us down, the food was always delicious. The hole in the wall restaurant we found turned out to be a place we returned to time time again.
Prints are available for each sketch for $250 and many originals can be purchased for $400. White museum grade shadow box frames are $100 more. You can e-mail Thor at email@example.com
Posted by Thor at 12:00 AM
Labels: Alison Brown, Istanbul, Louie, Turkey
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Many tools are associated with terrorists, but use of the internet could be one of the most unstoppable. The World Wide Web could be the perfect tool to radicalize, recruit, and operate terrorist activities. The House Homeland Security subcommittee on Intelligence, Information Sharing and Terrorism Risk Assessment held a hearing today to discuss the possible trade offs between protecting ourselves from an evolving tool of terror while preserving freedom. Internet terrorism must be dealt with before it reaches too far, but is there a point where regulation tramples the American idol of free speech.
Read the Full Story at KPCC Blogs


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New Voyages Goes Star Trek: Phase II
Star Trek: New Voyages is the occasionally brilliant, often amateur online series of new adventures in the TOS universe featuring recast members of the original Enterprise crew. In other words, it's got a bit in common with J.J. Abrams' upcoming Trek XI — except the hundred million dollar budget. It's a strange one: I love it for its fan moxie, but there's no denying it's not pro-level, no matter how many original cast members they get to appear.
Now the producers behind New Voyages have announced that they are changing the name of the series to Star Trek: Phase II. Usually, a title change of a fan series isn't worth commentary, but this one's extremely interesting. Phase II was the name of the re-launched series covering the Enterprise's second five year mission that Roddenberry himself tried to get off the ground.
To me, what the name change signifies is that these guys think they are now the official successors to Star Trek, no matter what Paramount says. They say the Phase II plans involve moving subtly from the look and feel of TOS to the look of Star Trek: The Motion Picture , and they will also be replacing some of their less stellar cast members, with a new Spock and Uhura coming into the fold. Cheeky, but interesting. Let's see where they go with this.
Star Trek New Voyages Fan Series Changes Name To Star Trek: Phase II [Trekweb]Read More


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WindTV: Wind power and Wyoming ranching go together
New revenue source helps rancher through cyclical nature of cattle business
WASHINGTON, DC, December 19, 2011– Wind energy can be as dependable and resilient as a Wyoming cattle rancher. Frame by frame, the bare images tell it all: black-on-white shots of cattle grazing on the wind-whipped landscape, a pickup truck lumbering by wind turbines that are barely visible in spite of being just a few yards away, and a pair of dogs, lingering at the feet of a trio of family ranchers. Aside from the insightful comments offered by rancher Shaun Sims, a howling Wyoming wind provides the soundtrack throughout the 90-second video.
The impact of wind power on Sims's family ranch in Wyoming is the subject of the latest segment on WindTV, the American Wind Energy Association's (AWEA) recently launched vehicle to highlight how wind works for America. All across America, wind farms provide an added source of revenue for farmers and ranchers through land lease payments. With wind turbines taking up a small fraction of land space, farmers and ranchers can continue to work the land while the wind above provides an additional source of income and fuels the production of clean electricity. For Sims, who operates the cattle and sheep ranch with his father and brother, wind power has provided a stabilizing revenue stream to help balance out the notoriously up-and-down nature of the ranching and farming business.
"The income coming off of the wind farm has been a huge benefit as far as being able to withstand those down times in the cattle and sheep markets, and it has helped improve our standard of living," says Sims. "That wind is going to blow in 30 years just like it does today."
Wind power, in fact, has helped Sims expand his business, allowing him to bring more family members into ranching. "What the wind farm has done is allow us to continue to ranch," says Sims, a fifth-generation rancher. He expresses hope that his grandkids will be able to share in the work and life associated with the profession.
The power of wind to bring new life to great American professions like ranching and farming, however, could stall if the federal Production Tax Credit (PTC) for wind energy is not extended. The PTC is scheduled to expire at the end of next year, and already developers are freezing plans for any new projects. By passing an extension of the PTC, Congress will save American jobs currently in danger of being shipped overseas and help the wind industry support 500,000 American jobs by 2030 as projected by the U.S. Department of Energy in the George W. Bush administration. A new study released last week finds that with stable tax policy the wind industry can create and save 54,000 American jobs just in the next four years, including growing the wind manufacturing sector by one third to 46,000 American manufacturing jobs.
"The story of the Sims family business epitomizes how wind power is as American as Wyoming ranching," said AWEA CEO Denise Bode. "All across America wind power is providing stable revenue to farmers and ranchers. Congress needs to allow the wind industry to keep doing what it does best�create affordable, homegrown energy and income for everyday Americans. It can do this by passing an extension of wind's primary federal policy driver, the Production Tax Credit."
WindTV is a showcase of video profiles of Americans whose lives have been positively impacted by the wind energy industry. The site, located at www.awea.org/windtv, features a different video profile each week.
To view the segment on Sims and how wind power and ranching go together in Wyoming, go to WindTV.
AWEA is the national trade association of America's wind industry, with more than 2,500 member companies, including global leaders in wind power and energy development, wind turbine manufacturing, component and service suppliers, and the world's largest wind power trade show, the WINDPOWER Conference & Exhibition, which takes place next in Atlanta, June 2-6, 2012. AWEA is the voice of wind energy in the U.S., promoting renewable energy to power a cleaner, stronger America. Look up information on wind energy at the AWEA website. Find insight on industry issues at AWEA's blog Into the Wind. Join AWEA on Facebook. Follow AWEA on Twitter.


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Why Britain Needs India
Another article in this week's Spectator highlights the benefits India brings to Britain,Continue reading
Migration in Reverse: UK to India
This week's Spectator has a great article on Brits of Indian origin heading back to the fast-growing superpower to make their fortune. (more…)Continue reading
UK – Big Brother is watching immigrants
In September 2012 the UK Border Agency intends to deploy the 'National Allegation Database', (more…)Continue reading
New Commonwealth Contractors site
Over the Olympic weekend, Commonwealth Contractors, the web's No1 resource for expat freelancers seeking UK work visa sponsorship, launched its new site. (more…)Continue reading
Google Launch 'Google Play' in bid to rival Apple's iTunes
Internet giant Google has re-launched its online store in an attempt to take on Apple's iTunes. Google's previous Android Market online store has not been as popular as anticipated. (more…)Continue reading
Contractors enjoy Great Places to Work
Top 30 Best Workplace Rankings 2010 – UK Organisations:
- Baringa Partners
- Danone Limited
- Impact International
- Microsoft Ltd
- Novo Nordisk Limited
- NetApp UK Limited
- Diageo GB
- General Mills UK
- Danone Waters (UK & Ireland)
- Admiral Group
- Abbott
- ALMAC Group
- ApaTech
- Beaverbrooks the Jewellers
- Bimouthmedia
- Bright Horizons Family Solutions
- British Gas
- Cadbury UK (Head Office)
- Chiswick Park Enjoy-Work
- Chubb Insurance Co of Europe SE
- Cisco Systems
- Coca-Cola Great Britain
- DAIICHI SANKYO UK Limited
- FactSet Europe Limited
- Fishbum Hedges Group
- Grunenthal Limited
- Huxley Associates
- Kellogg's
- Ketchum Pleon
- KRC UK and Ireland
For more information please see the greatplacetowork.co.uk
Commonwealth Contractors
Commonwealth Contractors is a collection of highly skilled professionals from the Commonwealth and beyond. We partner with OISC Registered Immigration Partners capable of professionally representing Tier 1 Visa Applications / Extensions AND Tier 2 Licensed Consultancy & Associated Trust Partners who may be prepared, where required, to sponsor a Medical, Information Technology or Engineering Professional on a Tier 2 Visa (formerly UK Work Permit).
To find out more call Commonwealth Contractors now on 0330 390 9021 or Submit your details now and we will get right back to you. Please be prepared to send a copy of a recent CV so that we can pass to interested partnersContinue reading
New Commonwealth Website
We are happy to announce that on the 17th December 2009 the new Commonwealth Contractors website went live. The new website brings together UK Work Visas (including Tier 1 & 2 Visas) & Skilled Consulting (in particular IT & Healthcare Consulting). Notably, CommonwealthContractors.com will now carry skilled job postings, especially those relating to the IT & Healthcare Sectors. If you are an employer or recruiter and you wish to advertise on CommonwealthContractors.com free of charge please feel free to contact Commonwealth Contractors today.
The new website is built around four key sections:
- UK Work Visas: Information on; applying for a Tier 1 (Highly Skilled) Visa, Gaining Tier 2 (Work Permit) Sponsorship, Tier 4 (Student) Visas, Tier 5 (Working Holiday) Visas, Ancestry Visas, European Visas and more
- IT & Healthcare Consulting: Guidance for International Information Technology & Healthcare Professionals wishing to work in the UK. Users of this section should be aware that skilled job postings will be detailed in the 'Latest News & Skilled Jobs' Section
- Agency & Overseas Partners: Information for prospective Corporate Partners, i.e.: UK Based Agencies, Overseas Agencies, Offshore IT Consultancies etc
- Expat Centre: The Expat Centre contains important information for those interested in; Going into business with a Contractor Limited Company, Living in the UK, Umbrella Companies, Finding a UK Contract etc
If you are a related website and you wish to carry Commonwealth Contractors news we are happy to write content for you where a back link can be provided.
Over the next few months CommonwealthContractors.com will be adding new functionality to improve the experience of web users. If you have any suggestions or you are experiencing issues using the new website please visit the Submit your details now and we will get right back to you.. Your feedback is greatly appreciated!Continue reading


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Making Impacts Globally and Locally
WSU Extension serves the residents of Washington State by creating and delivering targeted research-based knowledge and education. It's a mission the organization and its dedicated specialists have refined over the past century. Part of that process is communicating results.
These reports provide accounts of how our programs empower participants to better their lives. We hope the reports inspire you to join at least one of our courses or events, share your story, and provide feedback. Your involvement will help us improve our responsiveness and reach more individuals.
Community & Economic Development
- During the wildfire recovery, WSU Ferry County assisted with an agency workshop on federal assistance, statewide pilot project on wildfire recovery, and WSU Ferry County also coordinated more than $30,000 worth of hay deliveries for affected farmers and ranchers.
- Production of high definition "county profile" video for use in main street promotions, countywide tourism, and small business recruitment.
- Video production of a grasshopper workshop in collaboration with the USDA.
- Video production of water quality and grazing workshop in collaboration with Kittitas County.
- Serving more than 500 people and 20 small businesses with entrepreneurial and small business workshops on access to capital, marketing, social media, and analytics.
- Ongoing development of Ferry County grant program, workshops, and reporting system.
- Collaboration with Kinross, WA Department of Commerce, Tri-County Economic Development District, and Republic Chamber of Commerce to assist the gold mine in their social exit strategy.
- Supporting "Lunches from Lunches" (Republic Schools greenhouse project with Casey Harris) to assist with business plan development and economics of operating a small garden to provide food to the school cafeteria, while also providing workshops on the economics of food systems and food waste.
Master Gardener Program
- Supporting "Lunches from Lunches" (Republic Schools greenhouse project with Casey Harris) to provide public workshops on composting, planting, and maintaining small gardens.
- 7 Master Gardeners (quadrupled in size) with another class scheduled for January 2016 due to interest in the the program.
- More than 300 points of contact in 2015 with clients to support small garden and horticulture inquiries.
- Annual garden tour to showcase quality gardens throughout Ferry County.
4-H Clubs, Projects, and Grants
- Ferry County has one of the most active shooting sports programs in the State and one of the only programs with a shooting sports trailer.
- Ferry County remains as having one of the State's highest 4-H enrollments per capita at more than 4% of the County population. We have more than 135 4-H volunteer leaders with documented value of $27.04 / hour, and statewide our volunteer leaders are valued at $54 million.
- State and National TV media coverage with emergency market animal sale (reached as far as Oregon). Emergency market animal sale had a great turnout with bids exceeding the previous year. Market animal sales continue to rise, despite the declared state of emergency.
- Youth showcased robotics build at SpoCon (a regional SciFi and technology event where our Tech Wizards robotics 4-H youth presented and displayed their projects).
- 2015 District Teen Rally successfully concluded with youth from Spokane, Stevens, Ponde O'Reille, and Ferry counties. This is the first time it has been held in Ferry County in 11 years.
- 2015 was the first 4-H Leaders' Council fundraiser which made more than $2,000. Other fundraisers planned for the future.
- 2014 to present demonstrates significant program growth due to increases with open enrollments, 4-H enrollments, and new leader volunteers.
- We continue to have day camp or overnight camp every summer. In 2015, we had both a day camp AND overnight camp for our youth.
- Increased Tech Wizards grant programming capacity and continued funding opportunities in 2016.


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Amyloid β is a 4 kD peptide formed by the sequential cleavage of the amyloid precursor protein. It ranges from 39-43 amino acids in length and exists primarily in two isoforms, Aβ40 and Aβ42. The normal physiological function of Aβ is not well understood, but the aggregation of Aβ42 is a pathological hallmark of Alzheimer's disease, the most prevalent neurodegenerative disease affecting the elderly. Unraveling the molecular mechanisms through which peptide aggregation is initiated and proceeds is crucial for gaining a better understanding of the disease and designing new therapeutic strategies. Within our group, we have probed the mechanisms of Aβ aggregation using various in vitro and in vivo techniques (Kaminski Schierle et al., 2011; Esbjörner et al., 2014).
Amyloid proteins such as Aβ develop an intrinsic fluorescence lifetime. Research from previous group members revealed that Aβ develops an intrinsic fluorescence upon amyloid formation. State-of-the-art ab initio molecular dynamic simulations performed by our collaborators at the ICTP in Trieste and fluorescence spectroscopy techniques showed that proton transfer across the dense network of hydrogen bonds that stabilise the β sheet structure is responsible for this phenomenon, which can be used to directly probe Aβ aggregation in a label free manner (Pinotsi et al., 2016; Grisanti et al., 2017).
Fluorescence Lifetime Imaging (FLIM)-based sensor reports directly on amyloid aggregation state in vivo. The lifetime sensor reports on Aβ aggregation by monitoring the change in fluorescence lifetime of covalently attached labels. As the partially labelled peptide self-assembles the dye molecules are brought into close proximity. The increased local concentration of the dye causes increased self-quenching, which is accompanied with a decrease in the overall fluorescence lifetime (Chen et al., 2017). The lifetime sensor is a non-invasive and has been employed to measure the aggregation propensity of Aβ and alpha-synuclein (Kaminski Schierle et al., 2011) in live cells and in Caenorhabditis elegans.
A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors. Perturbing the process of amyloid aggregation is a key strategy for the development of therapeutic agents against the onset and progression of Alzheimer's disease. A variety of issues with current screening methods, including lack of reproducibility and high reagent consumption, have limited the efficiency of identifying small molecule inhibitors. Furthermore, the lack of methods for monitoring the anti-aggregation activity of hit compounds in live cells and whole organism models has previously restricted attempts to validate the activity of such compounds in living systems. Through the implementation of the lifetime sensor and microfluidic techniques (in collaboration with Prof. Hollfelder) we have developed an assay to screen for small molecule inhibitors. Using this assay, we have identified novel inhibitory compounds (in collaboration with Prof. Spring) which have been validated to suppress Aβ aggregation in cellular and C. elegans disease models.
Fluorescence Spectroscopy Techniques
C. elegans


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What are the differences between Infobus and the JavaBeans Activation Framework? Why would I choose one over the other?
Created May 4, 2012
As far as the Activation Framework goes, this isn't really about sending messages around, but sending data, where the data is flagged with mime types. You then discover the operations you can do on the data, based upon what type it is.
Which of the three you use really depends upon what you want to do. JMS is a standard part of the J2EE, as is the activation framework, so in many cases one of these two would automatically get the nod first.


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Service Areas for Competitive Licensing: 4-115 — Portage la Prairie
Tier 4 — Service Areas
This is the Tier 4 map for Portage la Prairie, Manitoba. The map illustrates the boundaries of the Tier 4-115 service area. Cities contained within the boundaries of Tier 4-115 include St-Ambroise, Macdonald and Portage la Prairie.
- Date modified:


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Best Sellers, Customer Favorites, Top Picks- it doesn't matter how you say it, what's important is that customers can see which items are loved by their peers. We are proud of our products that have earned a 5-Star Rating and have created this feature to share them with you. Introducing the best of the best, the tried and true items from our collection... as decided by you!
Our Lacquer Jewelry Box is sleek and simple, with just the right amount of embellishment to hold it's own against the beauty it contains. It has a removable inner tray with four compartments providing flexibility and functionality. Handcrafted in Vietnam.
★★★★★ "Bought two of these to give as gifts. Everyone loved them. Can be used for a multitude of things other than jewelry. Ended up buying another for myself."
Click here to see our other items featured in this Tried & True series.


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Jamie Tam
Jamie Tam is a Ph.D. candidate in the Department of Health Management and Policy at the University of Michigan, where she also received an MPH. As a junior investigator with the Cancer Intervention and Surveillance Modeling Network (CISNET) lung consortium, she is involved in work that simulates the effects of tobacco control policies on smoking and mortality outcomes. She received a BS in Biology from Stanford University and has previously served at the FDA Center for Tobacco Products and the Campaign for Tobacco-Free Kids. Ms. Tam's current dissertation work uses complex systems modeling methods to consider the relationship between smoking and mental illness and its implications for mortality and treatment outcomes. Her research broadly aims to investigate tobacco use disparities and the policy and treatment strategies to address them.


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There has been an increasing demand for cosmetologists all over the world for several years. Due to an increase in the consciousness among people for their looks and to retain youthfulness, many people look for the personal cosmetologists in order to keep them up in the race of changing fashions. These cosmetologists provide people with the services for their hairstyles, hair colors, nail arts, and facial makeovers. They are tasked with producing the best skills to improve the apparent look of their clients. To become cosmetologists, you may be able to opt for an Associate's Applied Science Degree in Cosmetology.
Cosmetology as a profession:
There are a large number of the people that have started taking admissions into schools that provide education for cosmetology. According to a survey report, growth in the demand of cosmetologists by the end of 2018 will be 20 percent, which is faster than most other professions. This means that it may be a good decision if a person wants to pursue his career in the field of applied cosmetology*.
Educational requirements for the course of cosmetologist:
There are not many formal requirements to become a cosmetologist. The leading cosmetology schools look for a high school diploma or its equivalence. However, the applicants are supposed to be more than 16 years of the age. Once a person fulfills these requirements, he or she may successfully find admission into a cosmetology college. Nevertheless, due to the limited seats available in these institutions, applicants may need to be intelligent enough to successfully pass the entrance tests.
It takes nine months for the traditional training in cosmetology in the certified barber salons and schools. Then people may be awarded with a degree of an associate of applied cosmetology. However, people can continue further to excel in the skills for the cosmetology**.
Courses to study in a cosmetology program:
There are numerous types of courses that are taught to the students in a cosmetology program. These students are taught cosmetology concepts and the tips for keeping a better salon. In addition to these, people are taught various behavior skills and interpersonal communication to deal with the clients. Moreover, people are made to learn the different research methodologies to introduce creativity and innovation in the ongoing fashion. In short, people are taught with all the skills required for the proper cosmetology techniques***.
After getting the degree from the certified schools for the education of cosmetology, people may be able to use the hairstyling techniques as well as the several other skills taught to them during the duration of their course. They can apply the different hair colors and introduce various styling techniques for their clients. A certified cosmetologist can perform a manicure and pedicure, and can apply different nail arts to outperform other cosmetologists in the same field. In short, to run this business successfully, people may be needed to take the relevant degree from the certified schools so as to fulfill all the legal requirements imposed by a government. In addition to this, people can also take the online courses for learning the best standards in applied cosmetology.
Are your ready to pursue a career in the Beauty industry? Get information on programs in your area and online using our beauty degree finder at the top of this page. ↑
*For more information, please visit: http://www.clovis.edu/type3.asp?pageid=cos
**For more information, please visit: http://www.msbcollege.edu/degree-programs/business/cosmetology-business/associate-degree/
***For more information, please visit: http://www.gtcc.edu/programs-of-study/cosmetology/associate-degree.aspx


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Review: 'Ready Player One' Escapes Into a VR Wonderland
Ready Player One | Steven Spielberg | March 29, 2018
Ernest Cline's 2011 novel Ready Player One was greeted as a loving homage to 80s pop culture as well as pop culture into the late 2010s, but it has since been reevaluated in light of its problematic elements and Gamergate. Vox has a comprehensive explainer on it, but that's not totally what we're here to discuss. The film at hand is Ready Player One, directed by wide-ranging New Hollywood auteur Steven Spielberg off of a script from Cline with rewrites co-credited to early Marvel/MCU film (and Last Action Hero) scribe Zak Penn.
In the year 2045, most of the world (or just the US, really) escapes the real-world economic problems by spending their time (and money, in some cases) in the OASIS, a VR world created by James Halliday (Mark Rylance) and Ogden Morrow (Simon Pegg). During the 5 years since Halliday's death, nobody has found the Easter Egg – preceded by 3 keys attained for completing 3 challenges of varying skill – that Halliday created as a challenge to decide his successor. Wade Watts (Tye Sheridan), known in-game as Parzival, is one of the many Gunters (Easter Egg hunters) and an early 20-something resident of the trailer park stacks in economically depressed Columbus, OH, along with his aunt (Susan Lynch) and her abusive boyfriend du jour (The Witch's Ralph Ineson). With his small circle of in-game friends Aech/Helen (Lena Waithe), Daito/Togarashi (Win Morisaki), and Sho (Philip Zhao), as well as crush/love interest Art3mis/Samantha (Thoroughbreds' & Me and Earl and the Dying Girl's Olivia Cooke) and their collective knowledge and in-game library of Halliday lore, Wade manages to complete the first challenge, which kicks the Easter Egg hunt into high gear and attracts the attention of IOI head Nolan Sorrento (Ben Mendelsohn), who wants to take over the OASIS and overpopulate it with ads. Adventure and peril ensue, as you'd expect, both in the real world and within the OASIS.
If it sounds thematically similar to Willy Wonka and the Chocolate Factory (or similar treasure hunt/inheritance movies) with a whole lot of pop culture references, you're not far off. Penn and Cline tone down the seemingly incessant explicit 1980s-2010s pop culture references from the book, instead turning them into updated blink-and-you'll-miss-'em cameos and references that are bound to leave audiences obsessing over which split-second cameo they enjoyed the most. I'm split between Marvin the Martian, StarCraft's Jim Raynor, Chucky, and Overwatch's Tracer. Maybe the best-executed one is the second challenge, focused around one of Halliday's romantic regrets and set in an amazingly ripped-from-the-screen recreation of a ghostly Colorado hotel.
The film does a better job with the characters and setting than the novel does. By compressing the events into, I'd estimate, several days to a week and keeping things in the Columbus area, the plot is expedited – and there's more time spent in-between the real world and the OASIS, and less on travel. However, the full realities and world of Ready Player One aren't fully grasped. There are hints of the state of technology (with pizza delivery drones – now a reality – and IOI's surveillance drones) and the economy, but the state of the US and the world as a whole isn't explored, since the focus is primarily on Wade in the Columbus area. Given Spielberg's prior dystopian films (A.I. & Minority Report), it's a little disappointing.
As for the core ensemble, Lena Waithe is fun to see as Aech a little more than Helen (more screentime for the former than the latter), Art3mis/Samantha has some shining moments, and Daito (Win Morisaki) and Sho (Philip Zhao) have a good line or two and are decently defined. Ben Mendelsohn chews the scenery a bit as Sorrento, and Hannah John-Kamen gets to do more on screen (than she did in Tomb Raider) as F'Nale Zandor, his head of security and the indentured servitude department. Additionally, Rylance (almost a Spielberg muse by now) chooses to play Halliday as being on the spectrum, which is fitting, given the character. I also liked the decision to reframe the challenges around Halliday's regrets, which added a Willy Wonka-like test element and a good bit of introspection.
But speaking of disappointments, there are problematic issues with character development. Samantha is better defined in the film and she's not as much of a princess/prize, as she solves the second challenge and provides key support during the final in-OASIS/in-reality battle. However, she still fits in the love interest trope, and given the 80s genre influence, the end result is clear. Helen, meanwhile, is referenced in passing in the novel as being a lesbian, and that's never explicitly stated in the film – erased, all but for a passing bit during the second challenge. Instead, there are a few brief "not what you expected" moments when everyone meets up – much sooner in the film to move the plot along – given the "you don't really know your online friends, do you?" mentality and identity creation that comes with MMORPGs. In addition to the mixed representation, there's the aforementioned Rylance decision on how to portray Halliday. Apart from that, there's also T.J. Miller's vocal and mo-cap appearance as I-R0K, an opportunistic hitman/hacker for hire who reflects more of the trollish traits associated with Gamergate – like helping Sorrento essentially dox Wade. But he isn't in a majority of the film, which is a relief, especially given the assault news about T.J. Miller as of late, the less Miller the better.
On a broader note, it's a very familiar yet fun (and slightly longer than it needs to be – if you count the end credits) escapist and wish-fulfillment film. Alan Silvestri's score is mostly lost to the 1970s/1980s soundtrack, but there are a few sly John Williams cues that you may be able to make out. But for all the fun, it doesn't quite have the heart in it. Yes, there are references galore, and yes, there's a nod to playing games for fun, but when the hunt is on, Ready Player One is focused on the thrill of the hunt.


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There are a range of venue choices in Broome, from outdoor ovals to indoor performance spaces such as the Civic Centre. For further information or to book a Shire venue please telephone (08) 9191 3456.
If you plan to obtain an occasional alcohol license for a one-off event on Shire property or public space, the Shire requires an Alcohol Management Plan. For further information telephone (08) 9191 3456.
The Shire will consider a 50% reduction on all charges (excluding deposit) to non-profit organisations, fundraising events or community events, upon application. The Application will be referred to the Chief Executive Officer and each application will be judged on its merit.
See the related information links below for relevant hire and booking forms.
Located Between Hamersley & Weld Street
The Civic Centre was built in 1973 and seats 450 people in the main hall. There is a raised stage which is often used for theatrical productions, dances and concerts. The stage area comes complete with dressing rooms, toilets and wash facilities.
A function room is suitable for meetings of 40 people and small displays are also available. Kitchen and bar facilities are located off the main hall and tables and chairs are included with the hire.
Cable Beach Rd, Broome
In addition to its sporting and leisure facilities, Broome Recreation and Aquatic Centre (BRAC) has the facilities to host special events, performances and exhibitions. BRAC's 1504 square metre indoor stadium is used annually for the North West Expo and the Worn Art performances. In addition to the stadium, BRAC has an 85 square metre multi-purpose room, toilets/change-rooms, food outlets and bar facilities.
Use of BRAC for special events, performances and exhibitions is subject to certain conditions and availability. It is a condition of use that the stadium floor be protected with carpet if any type of staging, props or chairs are to be used.
For further details, please contact the Centre Manager at BRAC on (08) 9193 7677.
Robinson Street
The Town Beach park complex provides an excellent venue for outdoor events. The Staircase Markets take place on the full moon and various festivals and events are held here annually.
Cable Beach Road
The Cable beach Amphitheatre offers magnificent views of Cable Beach and enough space to accommodate full stage production equipment, marquees and grassed seating for up to 2000 people. Spectacular productions from the WA Ballet and WA Symphony Orchestra, and festival events are regularly held here.
Both Haynes and Male Ovals are used for festivals and multicultural activities. Annual levies are charged to sporting organisations based on the particular sport.


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Wondering if there is a place for your in this battle for freedom and justice? Wonder no more!
We are, honestly, quite overwhelmed with all the opportunities and needs right here in our local area. We would love to have you join us.
Within the past two weeks Justice Network members and partners have attended fundraising socials, held various meetings, planned events, and prepared speaking engagements. We've also gathered and delivered donations and drafted the beginnings of new ministries and outreach.
This image shows donations that Justice Network brought to Restore NYC. We're so thankful to the girl scouts of Totowa, Cadet Troup 115, who chose to raise awareness about human trafficking by gathering this items. And to the Picatinny women (spouse group & PWOC) for their generosity of spirit, time, and finances.
Together we've been on the front lines, behind the scenes, and several places in between. Ready to stand with us?
Here are a few opportunities this weekend.
SATURDAY, MAY 2nd : Cut-A-Thon – Abolition Event 2015
- 9:00AM to 4:00PM
- Calvary Temple in Wayne, NJ
- "Salon" reservations can be made by going to calvarynj.com/contact/ and emailing a requested service
- The proceeds for the cuts and some of the vendors will be donated to Restore NYC recovery homes.


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Extraordinary dogs assist people, provide therapy and help to save lives. Follow amazing tales of man's best friend. Contribute your ideas and personal stories.
Wednesday, 2 September 2015
Unusual Dog Breeds
16 comments:
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The 12 principles of a Designer
Today we have a bit of a non-standard blog entry. It's not the interview but rather a lecture of a man working in the design sphere for over a decade. There will be no questions, just answers and there will be no real names.
Approval Studio vs Quickreviewer: choosing a design proofing tool
It's totally normal that working on a review\proofing tool we pay attention to all the competitors on the market and every new face in the sphere catches our eye. Read more
We want to hear you!
Our team researches the possibility to reduce the operational costs for design and creative teams. As the outcome of our research, we intend to release the artwork review and approval process automation solution. Read more
Design & psychology
Today, I want to share with you, probably, the most interesting conversation that we had up until today. Daniel May is a design professional, who's been working with such companies like Sony and BMG, and it's possible, that some of his works you can find in your music collection on the CD covers. Nowadays, Dan shares his experience with students of the University of Nebraska, teaching the design and I really envy his students, as Daniel is magnificent storyteller and knows how to inspire people. Unfortunately, plain text of the interview cannot share the atmosphere that Daniel creates with the help of his voice, manner of speaking, body language… Read more
What is the best collaboration tool for UX\UI designers?
Today, we are talking to Andrii Horbachov and Dmytriy Kravchenko – the co-founders of Brave Wings digital bureau, UX\UI specialists from Ukraine. These guys have truly remarkable works in their portfolio, some of them can be found on Dribble, other projects cannot be shared in free access, due to contract restrictions, but believe me, they are even more interesting and complicated. Read more
Packaging design as science
I've heard a lot of criticism about the design choices made by different companies while releasing their products to the market. Nowadays, having a high-quality product in the box might be even less important than having a nice, eye-catching and appealing box, as when you "meet" the product for the first time – you see its packaging, but have no clue what's inside of it. Read more
Resident Evil VII Branding Analysis
Resident Evil 7: Biohazard is a survival horror game developed and published by Capcom, released in January 2017 for Windows, PlayStation 4, and Xbox One, and in May 2018 for the Nintendo Switch in Japan. Diverging from the more action-oriented Resident Evil 5 and Resident Evil 6, Resident Evil 7 returns to the franchise's survival horror roots, emphasizing exploration.
Communication with client & design innovations
While working on the web-app, targeted for creative teams, our Approval Studio guys have carried out a big research, making interviews with Project Managers, Team Leads, Design Professors and Specialists working in different creative spheres, such as packaging design, label design, interior design, UX/UI design, etc. The most interesting conversations will be published here, in Approval Studio blog. Read more
Roasting the Package of "Nonexistent Vodka"
Today we are going to discuss a very unusual representative from the world of alcohol and rightfully judge it by its cover and package. Vodka Nonexistent – is its design as good? In the struggle for customer curiosity, Nonexistent plans to use two methods at once: optical illusion and space capture.
The bottle and lodgement merge on the shelf into one bright illusionist pattern, eventually evoking the question: "Is there any vodka at all?" creators imagined? Let's take a closer look together. Read more
Five Achilles' Heels of Every Packaging Project
Each package is great in its own unique way, but most of them face pretty similar problems. We at Approval Studio have systematized the most typical issues and described five Achilles' heels of every packaging project. Check yourself before adding a fresh artwork to your portfolio or sending it to a publisher. No need? Well, at least you can laugh at our witty out-of-the-context comments. Read more
What decreases the profitability of a creative team? My personal experience in fixing that
I used to work as the Project manager and Creative director and noticed that the majority of our projects were losing profitability due to the simple reason – miscommunication. And I mean internal miscommunication within a team and with the client as well. As the result we had to miss the deadlines several times and clients were unhappy even if it wasn't totally our fault. Read more
What is the main cause of a headache in creative direction? Nick Schön`s vision
During the last months, I`m asking CDs, Art-Directors and design managers the one question – what is the main headache in their job? This exciting experience became a good source for some blog series I`ll share with you later
Nick Schon`s answer is great and I`d like to share it with you, guys as it is Read more


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A fierce soldier fighting for the Spanish cause in Flanders returns to a drastically different Spain to fulfill the dying wish of a fallen friend, only to find that life isn't what it once was in his decaying homeland in director Agustín Díaz Yanes' adaptation of Arturo Pérez-Reverte's popular series of best-selling books. Compelled to fulfill the final wish of his dying friend, noble warrior Alatriste (more
All Alatriste photos
All Alatriste cast + crew photos
Movies.com, the ultimate source for everything movies, is your destination for new movie trailers, reviews, photos, times, tickets + more! Stay in the know with the latest movie news and cast interviews at Movies.com.
Copyright © 2020 FANDANGO MOVIES.


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Trainee executive search consultant
Trainee executive search consultant
Basic to £22k and first year OTE circa £28k
The company:
Set up over ten years ago by two highly experienced recruitment /search professionals, the business has grown and can now boast two UK offices and an office in Singapore. The business is being driven by a director who has 7 years service and a proven methodology for training sales professionals to become successful recruiters.
The role:
- Initially your focus will be candidate sourcing and generation, working alongside a senior consultant to learn the art of headhunting
- Whilst conducting your candidate approach calls you will build up rapport and look to identify company leads for your senior consultant to then approach to procure new business
- Research, identify and qualify candidates as you will be managing recruitment projects from inception through to completion
- Continuously developing your industry network and brand with a view to becoming a true industry expert
The person:
- With a strong background in B2B sales and ideally exposure to the recruitment industry
- A methodical approach and not an individual looking for a quick win
- Able to demonstrate a stable career to date that shows the ability to push through when things get tough
- Excellent business acumen
- Strong communication skills with the ability to liaise at a very senior level
Why would you want this role?
- An opportunity for intense on the job training
- International travel
- A generous basic and commission scheme with no threshold
- Weekly and quarterly incentives
- A great team environment


text: Toyota's F1 driver Timo Glock drove the Formula 1 car along side of the Batmobile which was driven by Jarno Trulli. In our opinion the Batmobile should be the next F1 Safety Car .Silverstone witnessed an unlikely pair of high speed motors sharing a lap on Thursday, as one of Panasonic Toyota Racing's TF108 Formula 1 cars drove head-to-head with the Batmobile .The star of the new Batman movie, The Dark Knight, was escorted by Toyota's Timo Glock around the famous Northamptonshire racetrack. Although 4.5 metres in length, the Batmobile and its owner are used to dealing with tight spots and they handled Silverstone's corners with ease. The Batmobile is around 3m at its widest point, 4.5m long and 1.5m high and weighs in at around 2.5 tonnes however the absence of a front axle enables it to make extremely tight turns.


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Posted in Michigan January 08, 2016
These 9 Unique Restaurants In Michigan Will Give You An Unforgettable Dining Experience
Sometimes you want a dining experience that's off the beaten path, a place you wouldn't normally include in your weekly or monthly itinerary. Well, we have a feeling that some of the spots on this list will make their way onto your bucket lists. Take a look.
Kind of irresistible, huh? Go ahead and make those dinner plans. Better yet, tell us about your absolute favorite and truly unique dining destinations across Michigan.


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Want to improve your speed, agility, vertical jump, and overall lower-body explosiveness?
Try adding the isometric squat to your training, according to research from the Journal of Strength and Conditioning Research, which found a strong correlation between an isometric squat — performed at (knee flexion angles of) 90° and 120° — and strength and explosiveness.
The isometric squat is performed by pausing in (and holding) the "down" position for some period of time (for example, 1-4 seconds).
As with any squat exercise, you can use body weight, a dumbbell or kettlebell (goblet style), or barbell (front or back squat).
- Start in upright position, with hips and knees fully extended
- Slowly lower your body by pushing your hips back and toward the ground
- Keep chin and chest up, and heels on the ground
- Pause when knees are bent at 90° to 120°
- Return to starting position by pushing hips forward, and extending hips and knees
- Repeat for pre-determined number of repetitions
Please see related articles, Get Stronger with Isometric Exercises and Add Isometric Exercises to Your Training Regimen.
Get STRONGER, Get FASTER!
Your thoughts?


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David Hoffman is UMBC's assistant director of student life for civic agency.
I work every day with UMBC students developing innovative solutions to problems on campus and beyond. They are applying their skills and passion to work that builds community and significantly advances the common good.
For those wanting to devote their creative energy to policy problems facing the City of Baltimore: The Johns Hopkins University Institute for Policy Studies and The Abell Foundation hope to hear from you. Together they are offering the Abell Award in Urban Policy (up to $5,000) for a compelling paper that addresses a Baltimore problem and provides a feasible solution. Full-time graduate and undergraduate students at 13 area universities including UMBC are eligible to apply.
The deadline to submit an entry form is October 18, 2013, with the final paper due February 24, 2014. The Johns Hopkins Institute for Policy Studies website provides additional information about the award, including links to all the winning papers from previous years and profiles of the people who submitted them.
Contact the author, David Hoffman, at email@example.com.


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Otto Meyerhof Biography (1884-1951)
- Nationality
- American
- Ethnicity
- German
- Gender
- Male
- Occupation
- biochemist
The son of a merchant, Meyerhof received his medical degree from the University of Heidelberg in 1909. Although he was originally attracted to psychology,a meeting with Otto Warburg aroused his interest in cellular physiology and,in 1913, when he joined the faculty of Kiel, he began what was to be a lifelong investigation into the biochemistry of muscle.
At the time, it was already common knowledge that muscle contained glycogen and that--as Frederick Gowland Hopkins and his coworkers had shown a decade earlier--a working muscle accumulates lactic acid. With these facts as startingpoints, Meyerhof conducted a series of experiments and, in 1919, demonstrated how the glycogen-lactic acid cycle works. In phase one, when the muscle begins to contract, glycogen is converted to lactic acid. Oxygen is not consumed, but an oxygen debt is built up. In phase two, when the muscle rests after work, molecular oxygen is then consumed to pay off the "debt" and to oxidize about one-fifth of the lactic acid. The energy yielded from the oxidation process makes it possible for the remaining four-fifths of lactic acid to be reconverted to glycogen.
Meyerhof's discovery elaborated the observation of Archibald Vivian Hill, in1913, that heat was emitted and oxygen consumed only during a muscle's contraction and its recovery. Hill and Meyerhof shared the 1922 Nobel Prize in physiology or medicine for their work on the biochemistry of muscular action. Meyerhof's work also laid the groundwork for Carl and Gerty Cori's more detailedexplanation, a few years later, of the steps by which glycogen is convertedto lactic acid (a process thereafter often known as the Embden-Meyerhof pathway, after Meyerhof and a coworker)
Like many other Jewish scientists, Meyerhof left Germany in 1938 after the Nazis rose to power. Unfortunately, the biochemist settled in Paris, France, and was therefore forced to flee a second time when the Germans invaded Francein 1940. Meyerhof then came to the United States and became a professor of physiological chemistry at the University of Pennsylvania, in Philadelphia, remaining there until his death.


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Did you know that citrus fruits are considered a secret weight-loss weapon because of their fibre content and low glycemic loads? Studies have shown that a person can actually lose weight while eating larger quantities of food by choosing foods high in fibre and water content such as citrus fruits.
Citrus fruits include oranges, lemon, grapefruits, tangelos, lime, clementine, pomelos and tangerines. According to Dr. Barbara Rolls, the Guthrie Chair in Nutritional Sciences at Pennsylvania State University and author of Volumetrics, "Citrus is excellent for weight loss because it can be eaten in satisfying portions for very few calories. The fruit also provides beneficial vitamins and nutrients, which is important for a weight loss plan because people are at greatest risk of nutrient deficiencies when they are cutting calories."
Citrus fruits will do the trick because they provide fewer calories per gram and provide a greater feeling of fullness after eating. They also keep blood sugar levels more constant which result in better appetite control.
Here are a few reasons to choose citrus fruit diets:
- THE GRAPE FRUIT DIET: The famous Grapefruit Diet has been around for years, and new evidence shows that grapefruit does indeed result in significant weight loss. Scripps Clinic scientist Ken Fujioka conducted a 12-week study on 100 obese men and women and concluded that eating one half of one grapefruit before meals resulted in an average weight loss of 3.6 pounds with some participants losing more than 10 pounds. The research indicates a physiological link between grapefruit and insulin, as it relates to weight management. Fujioka speculates that the chemical properties of grapefruit reduce insulin levels and encourage weight loss.
- THE LEMON FRUIT DIET: Although lemon has been met with a lot of criticism from health advocates, there is no denying that the fruit has the ability to provide dramatic weight loss in a short period of time. The lemon diet gets a person to eat little or no solid food. This puts a pause on any unhealthy eating habits and gives the body a break. This is one likely means of ensuring weight loss in many individuals. All a person has to do is drink freshly squeezed glasses of lemon as many times as possible in the day. This can be mixed with water (or ice preferably).
- THE ORANGE DIET: The orange diet is a 2-day designed diet meant to quickly eliminate excess body weight and accumulated toxins. It involves two days without solid food and eating as many oranges as the necessary. There is also the Orange Juice Diet which is a simple way to lose weight over a two week period. This involves drinking as much freely squeezed organic orange juice as a person desires, as often as possible. Doing this gives the body a good cleansing as well as rejuvenation on a cellular level.
- THE POMELO DIET: This citrus fruit is rated an excellent weight loss food. The delicious fruit has properties which curb appetites and fight bacterial infections. Eating one solid balanced meal in the right proportions while substituting the other meals with 2 or 3 pomelos over 2 weeks will show significant signs of weight loss.
Melting away fat using citrus can be the start to a healthier lifestyle. Embarking on these diet journeys not only forces a person to eat less but to realize how dependent we actually are on sugar, stimulants, and fatty foods and then learn to avoid them healthily.


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Old Hollywood glamour was seen at the premiere of A Week in London! This light-hearted comedy was viewed at the Cinerama Dome in Hollywood, CA by an eager audience of over 1000 fans!
Our very own Candace Kita has a lead role in this film opposite Julia Faye West, Denise Richards, and Mike Tyson, among others. We followed Candace as she went to this illustrious affair!
Candace left Hollywood Center Studios that evening and arrived to the Cinerama Dome wearing a daring see-through gown by Moda Glam Boutique. The press described this gown as "stopping traffic on Sunset Blvd. when Candace Kita entered the theater"! This sequined, full length gown was accessorized by a black velvet choker with a jeweled cross by Glamarella Jewelry and rings by stylist Holley Wolfe. Candace brought a vintage handbag from London that had been her mother's purchased in the 1960s. Makeup and hair were done by Melissa Riso who chose sheer, dewy makeup with nude lips, pink cheeks, and taupe eye shadow to compliment the look.
Candace's partner, Doug Jeffery, owner and CEO of 41 Sets, also looked dapper in a Hugo Boss midnight blue jacket and black pants. He accessorized this look with horn-rimmed glasses and a Rolex watch.
The autograph hounds were there to greet her car, but many didn't recognize Candace; in the film she plays a 450lb. woman, Dong Su. Dong Su was created by a team of talented special effects and makeup artists. The makeup and prosthetics took over five hours to achieve and the process of creating Dong Su began weeks before principle filming started.
A Week in London follows an heiress, London Logo (played by Julia Faye West) and her quest to show the world she isn't just another pretentious celebutante. Her rival is Dong Su. Only now, Dong Su has become slender after winning a weight loss reality show. She has been transformed into Kristy Kim, the new "It" girl and London Logo's biggest rival. Watch as the fur flies and the claws come out in this comedy that has been compared to Airplane, Spinal Tap, and Best in Show!
A Week in London is coming to a theater near you soon!


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Workplace Futures 2007: The Convergence of Property and FM
Property and facilities services providers are drifting out of sync with the expectations of the marketplace. Corporate clients are increasingly looking at the big picture; we're still looking at the details.?
Delegates at the first Workplace Futures conference, organised by i-FM, were told that fundamental change is already well underway at many large organisations. Mike Cant, Consultancy Director at Larch Consulting, Deputy Chair of the RICS FM Faculty and Chair of Action FM, argued that clients are less and less interested in the elements of estates and facilities management and more and more interested in finding appropriate support for their business or their brands. ??
Paul Carder, Head of Business Development at IPD Occupiers, made a similar argument. The challenge for corporates, and for their providers, is to find ways to effectively capture and understand management information on the factors that lie at the heart of business – space, the work environment, productivity, for example. "Cost reduction is reaching the bottom of the curve," Carder said. "The time has come to think bigger - and harder about how we can increase the value we add." ??
Delegates also heard Gareth Hollyman, Head of FM Operations at Jones Lang LaSalle and Chairman of the FMA, propose that managing – and reducing – risk was a key area where the sector can add value to client organisations.??
The event opened with Howard Morgan, Managing Director of Kinsgley Lipsey Morgan, setting the scene for the introduction of REITs and the implications of that for service providers. John Robinson, EMEA Operations Leader at Trammell Crow also explained how integrated services are already being provided to their client EDS.??
The second half of the event opened with a question: the past decade has seen considerable social, economic and technological change - but there have been no big innovations in FM. Why not?
That was the challenge posed by Oliver Jones, CEO of the Asset Factor, when he took the floor at Workplace Futures??
Jones was following up on a theme first introduced by Rick Bertasi, VP Real Estate and Facilities Management EMEA at Johnson Controls. Bertasi had argued that with all the 'low-hanging fruit' of first and second generation outsourcing virtually gone, the question now for service providers is - what next? He highlighted opportunities in 'workplace strategy', a common ground that links the silos of the traditional property and FM service structure. But, Bertasi warned, moving into this area successfully involves rising to the challenge of new client needs which, in turn, means more emphasis on strong business skills in addition to existing technical skills.??
Clients are increasingly taking it for granted that service providers will have all the necessary skills, systems and procedures in place, said David Fettes, Corporate Real Estate Director at Carillion FM. They are less interested in the operational aspects of estates and facilities, and more interested in strategies and outcomes, he said.??
Steve Hutton, Intelligent Property Group Business Development Director, outlined an effective approach to ensuring that outcomes align with strategy, highlighting the importance of bringing people and process together with the 'glue' of technology to deliver critical real-time management information. Charles Shaw, MD of Arlington Business Services, added more flesh to the bones of implementation with a strong argument in favour of perceiving building occupants as customers - and treating them as such.??
Oliver Jones rounded off the conference presentations by noting that the optimisation of space, people and workplace infrastructure is a challenge that remains largely unaddressed by FM. What we need, he argued, are new, innovative solutions that will work for a range of client organisations.??
The focus of the conference was the growing trend towards the convergence of property services and facilities management. Confirmation that there is a demand for integrated delivery came in the form of an impassioned plea from one client-side representative in the audience, who urged providers to 'just get on and do it'.


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We gained a future-proof solution for supporting excellent digital patient care and critical hospital applications. Doctors can rapidly access their patients' electronic health records, allowing more time for quality consultations, improved access to test results and targeted diagnoses and care.
– Roman Haselsberger, IT Manager, Kufstein District Hospital
Hitachi Clinical Repository gives us the flexibility to integrate any type of clinical system into a comprehensive archive.
– Elmar Flamme, CIO, Klinikum Wels-Grieskirchen
Hitachi Data Systems, Pentaho and Hitachi Insight Group are now one company: Hitachi Vantara.
Get more data-driven solutions and innovation from the partner you can trust.


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In school, engineers and scientists learn to prioritize aspects of their work in a particular way. While hard deadlines are never "ideal" (and are often set arbitrarily), they are at least adjustable by the instructor. Bad instructors make a mess of things, but good instructors (I'm sure we can all remember a few) are masters at balancing due dates and project work loads so that their students have the time to adequately build essential skills.
The focus is all on the work — what to build, how to design it, how to build it, how to allot your time, and so on. In many ways it's like learning how to operate in a vacuum; without a host of problems beating down your door on a day to day basis, you can learn how to balance design, time spent researching pre-existing tools, time spent coding, time spent automating one's processes, et cetera.
If you go to work for a startup, kiss all of this goodbye.
From an engineer's perspective, a startup's priorities seem to put the cart before the horse. This can be frustrating at first, but it helps to realize that this is a good thing. If most engineers or scientists were at the helm, the team would spend its entire runway building and building. Sales is meant to pull engineering along at a clip; this is not ideal from the viewpoint of the engineer, who often has learned to work in the university environment described above, but it is real.
Step one is acceptance. Step two is learning how, on a daily basis, to ask the right questions about your work. Asking the right questions and making small adjustments as one goes keeps building momentum, and nothing is more important than keeping things moving.
Informed stoicism in the workplace
"I was stoic before being a Stoic was even a thing."
Step one is to not fret. You're going to have to pull the trigger on things you feel are half-baked or require more time. However, you have to realize that on some level this is distorted thinking. Piecemeal solutions are required, and often an engineer or scientist's drive is to build the most elaborate, detailed, complete system possible. The problem with this (common knowledge among tech managers and graduate student advisors) is that researchers/developers tend to dig themselves a deep hole. To switch metaphors, they tend to spend a lot of time putting a spoiler onto a hoopty.
The important thing to remember as a developer, scientist, or engineer at a company is that your skills are intended to fit into the overall goals of the organization. Removed from the vacuum of pure work, what was once sterile, controlled surgery becomes field-medic work with a tourniquet and a handsaw. This can be hard to balance emotionally; people are rushed, and there's always a cofinite amount of work remaining, no matter how much is done. When you've learned to approach projects from a "from scratch to full completion" mindset, it can be frustrating to move toward doing what one can, laying one brick at a time here and there.
Step two is to realize your own mind's place in the machine you're building. Startups can be viewed as a big machine, part computational, part psychological / biological. We aren't simply charged with optimizing our code, we are charged with optimizing ourselves, our work routines, our practices. There's a balance to be struck here as well; clearly we can't spend all day automating our tasks, all day reflecting on method, as day-to-day things must be done.
What it boils down to is asking the right questions and doing what one can when one can. This might sound obvious, but it's a matter of practical mindstate. The focus should not be on making things ideal, this will never happen. Rather, it should be on maintaining forward momentum however one can. If you realize you're typing the same things over and over again, hack up a quick script to speed yourself up. Once you've done this with a few tasks (and if you rely on this quick tools enough), you have a good set of candidates for inclusion into a more comprehensive tool. This can be done piecemeal alongside more pressing daily goals. Doing it piecemeal also means that you don't waste time building out functionality that ends up being not that useful.
Optimization is a lifestyle choice
It won't do to simply sit down every few weeks or months and say "what could I do to improve my daily practices?" It's something to think about on a daily basis, bringing awareness to every task. What do I spend my time on? Am I typing the same things over and over? Would it simplify my code if these various functions were phrased more generally, or in a module?
While we can't stop to address the answers to these questions whenever we want, simply asking them and keeping them in mind is useful. It helps orient us toward what needs to be done when the time comes. This helps us reach a more ideal situation through small, doable steps.
About the AuthorMore Content by Mike Freenor


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