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Do you always dry your hair using the highest heat setting on your hair dryer? Of course, this will dry your hair the fastest but it might not be the best option depending on your hair type and how wet your hair is. Huffington Post tapped into hairstylist Josue Perez for his opinion on what temperature your hair dryer should be.
Perez says the different levels of heat should be adjusted according to your hair's texture and condition. "The high heat is available for really thick or coarse hair, and to remove excessive moisture when the hair is really wet, but always remember to keep the dryer moving and never focus on one portion of the hair for too long," he said. "The low setting is perfect for thin or fragile hair. If your hair is only damp instead of wet, it is important to use the low heat setting to prevent over-drying."
To help set your hair in place, use the "cool shot" button. It will seal the hair cuticle, add shine and hold your hair in place. Perez suggests, "When your hair is about 80 percent dry, switch over to the cool shot."
Next time you blow dry your hair, try not to automatically blast the heat!
Don't miss how to create the perfect messy bun and everything you need to know about hair static!
[Photo: Shutterstock]


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The peculiar genesis of Super Buffet
Pete Bayard: "My sketch demos are skeletal"
Dryw Keltz 2 p.m., Jan. 23
Genre: Classical, Latin | Tejano
No shows scheduled | Post a show | View show history
Inception: San Diego, 1996
Salsa band Orquesta Primo was founded by three cousins (primo means "cousin" in Spanish). They frequently play at the Belly Up's Salsa Sundays.
The band's keyboard player Lester Alvarez was detained for 25 days in 2000 when he immigrated from Cuba while playing with a 12-piece salsa band.
"I said 'I am a Cuban refugee....' They put me in a private jail. I don't know where it was. They don't give you that information." He said he wore handcuffs and leg shackles when he was transported. "Then one day they say, 'Get your stuff and walk out....' The government gave me an E-94, which is permission to stay in the U.S.... After five years you can apply to be a citizen." Unlike Cubans, Mexican citizens detained at the Tijuana border are automatically deported.
Alvarez also plays with an Afro-Cuban combo called De Corazon.

subset: commoncrawl


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By DAN FREEDMAN
and RICK DUNHAM
Advocates of stricter gun legislation, emboldened by a shift in public opinion following last week's school shootings in Newtown, Conn., pushed Monday for a renewed assault weapons ban and other gun control measures that have failed to gain traction over the past decade.
Three days after a gunman took the lives of 20 children and six adults with a Bushmaster .223 semi-automatic rifle, several pro-gun lawmakers — including Senate Majority Leader Harry Reid, D-Nev. — said they were willing to consider new firearms legislation.
"We need to accept the reality that we are not doing enough to protect our citizens,'' said Reid said in a statement on the Senate floor. "In the coming days and weeks, we will engage in a meaningful conversation and thoughtful debate about how to change laws and culture that allow violence to grow.''
Even Sen. Joe Manchin, D-W.Va., a longtime NRA member with an A-rating from the powerful gun lobbying organization, said "everything should be on the table."
Appearing on MSNBC, he added that Second Amendment rights would not necessarily be violated by controls on high-capacity magazines. "I've never had more than three shells in a clip," said Manchin. "I'm a proud outdoorsman and hunter, but this doesn't make sense.''
Statements from Democrats such as Reid, Manchin and Sen. Mark Warner, D-Va., — who said Monday "the status quo isn't acceptable'' — are a key measure of strength for gun control because even though the party is generally sympathetic to restraints on firearms, these senators and others with significant pro-gun rural constituencies have insulated themselves in Republican-leaning states in part by championing gun rights.
But it wasn't just lawmakers who were reassessing their views. Support for stricter gun control measures has reached a five-year high in the aftermath of the Connecticut school massacre, according to a new ABC News/Washington Post poll released today.
Fifty-four percent of Americans back new controls on guns — and 59 percent back curbs on the high-capacity ammunition clips used in many of the recent shooting rampages.
Another shift: Gun control supporters now have more intensity than opponents of stricter controls. Forty-four percent of Americans say they "strongly" favor stricter action while 32 percent say they oppose new controls "strongly."
Gun control advocates — led by New York Mayor Michael Bloomberg and backed by Connecticut Gov. Dan Malloy — pushed for swift action in Washington.
Sen. Dianne Feinstein, D-Calif., said she would introduce an "updated'' assault weapons ban that would outlaw 100 specifically-named firearms, weapons that can accept detachable magazines as well as certain semiautomatic rifles, handguns and shotguns that can accept a detachable magazine and semiautomatic rifles and handguns with a fixed magazine that can accept more than 10 rounds.
Feinstein is the author of the assault weapons ban that became law in 1994 but expired in 2004 when Congress refused to renew it.
Sen. Charles Schumer, D-N.Y., also is likely to re-introduce legislation to require universal background checks on all weapons transactions. Current law requires background checks on weapons sold by federally licensed firearms dealers. Schumer's measure, along with a similar bill by Rep. Carolyn McCarthy, D-N.Y., in the House, would also require background checks on transactions between private parties, with a few exceptions.
Nevertheless, members of Congress who favor gun control face what may prove to be an insurmountable barrier of lawmakers from both parties who are not likely to change their support for gun rights.
For the most part, pro-gun Republicans who control the House remained conspicuously silent Monday. "One indisputable call to action from the Connecticut tragedy — SECURE YOUR GUNS IF YOU OWN THEM,'' Rep. John Carter, R-Texas, said via Twitter.
But opposition to new laws nevertheless percolated from a few House members such as Rep. Gene Green, D-Texas. "Instead of saying we need to outlaw certain types weapons, we need to find better ways to enforce current law,'' Green said in an interview. "The kneejerk approach of those who want to control firearms may not be the solution.''
He predicted that neither the proposed assault weapons ban nor the expanded background-checks proposal "would move in the House.''
Gun control advocates acknowledge the climb may be steep to get gun-control legislation through Congress. But they say that unlike previous incidents such as the one at a movie theater in Aurora, Colo., in July, in which a shooter, James Holmes, took the lives of 12 and wounded 57, the drumbeat for change in gun laws is much stronger in the wake of the Connecticut shootings.
"We have to change the paradigm and culture on this issue,'' said Colin Goddard, federal of the Brady Campaign to Prevent Gun Violence, who survived four gunshot wounds in the 2007 Virginia Tech attack in which 32 died. "We've got to get over the dismal, bleak outlook that nothing can be done.''
A fellow Houston Democrat, Rep. Sheila Jackson Lee, D-Texas, expressed strong support for both an assault weapons band and universal background checks.
"This Congress must rise above partisan politics and now come together to pass these important gun safety laws,'' Jackson Lee said in a statement. "The safety of America and its children should be at the forefront when it comes to making these gun safety laws.''
But another Texas lawmaker, Rep. Louie Gohmert, R-Texas, said on Fox News that more people carrying guns is the best defense against mass shooters.
If the principal at Sandy Hook Elementary School, Dawn Lafferty Hochsprung, had been armed, "she . . . takes his head off before he can kill those precious kids,'' Gohmert said.
Such views are common in most of Texas but are particularly prevalent in more rural areas of the state, said Cindy Rugeley, a political science professor at Texas Tech in Lubbock.
"Most people out here think the answer to gun violence is more guns, not less,'' she said.
Even so, Rugeley said resistance to new gun laws, particularly in more urbanized areas such as Houston and San Antonio, would only go so far.
"Do I think Texans and Texas representatives would oppose an assault weapons ban?'' she said. "Yes.''
However, "if something passed, would the average Texan be outraged, up in arms?'' she added. "No, I don't see that happening.''


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One of the surprises of the last English Premier League season was Tottenham Hotspur. Long a club full of ambition and rich in history, yet in the modern Premier League history things often failed to click for Spurs. That was until last season. Under new veteran manager Harry Redknapp, Spurs finally broke the stranglehold of the big four English clubs -- Manchester United, Liverpool, Arsenal, and Chelsea. With Spurs now on the cusp of Champions League football and with a new stadium in the works, Spurs are seeking to solidify themselves as one of the big clubs, not just in England, but in Europe. They are currently on a pre-season tour in the US in order to increase their visibility in their presence in the increasingly lucrative market, and they will notably be facing off against the New York Red Bulls and old Arsenal nemesis Thierry Henry next weekend.
But with Spurs' visibility growing, many Americans may be scratching their heads asking, what in the world is a Hotspur?
Such a question wouldn't be asked about our own San Antonio Spurs, as their name is a clear ode to the cowboy legacy of Texas. But when we think of North London, few think of marauding warriors on horseback. Yet that is exactly where the name comes from. The founders of Tottenham Hotspur football club in 1882 wanted a name for their club that invoked a fighting, yet flamboyant, spirit. No doubt, being some of the better read football fans of the age, they went to Shakespeare for inspiration -- where the figure of Harry Hotspur drew their attention.
Harry Hotspur -- actually Henry Percy -- was a knight who received the nickname "Hotspur," reflecting his impulsive nature. He also earned a reputation for being a great warrior, as he took on the Scots and the French (the founders of Tottenham no doubt had the foresight to know that archrival Arsenal would eventually become a shadow French national side). In 1403, Henry Hotspur, seriously pissed off about Henry IV's murder of Richard II, decided to do the sensible thing and led a rebellion against the crown (something that should appeal to any American). This predictably ended in catastrophe, but Hotspur is seen as going down fighting courageously and gloriously. Shakespeare later immortalized Henry Hotspur in Henry IV.
Thus, the founders of Tottenham Hotspur -- known as Spurs for short -- also hoped their team would play fighting, yet entertaining and flamboyant football. As a result, Spurs have as a club policy long emphasized playing aggressive, flowing football (sometimes to the detriment of their defense). Their team's motto, plastered along the cozy confines of their stadium on White Hart Lane, reads "to dare, is to do," which no doubt evokes Henry Hotspur's spirit.
In the U.S., we are used to unique team names, varying from the classic Yankees, Red Sox, Buckeyes, Packers, Steelers; yet in a sport filled with Uniteds, FCs, Cities, Reals, Athleticos, Rovers, and even Wanderers, it certainly is refreshing that there is only Hotspur.


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Inspiration videos by Joe Capra
Joe Capra is the man behind this panoramic time-lapse teaser of Los Angeles.
We discovered Joe Capra, AKA Scientifantastic, in a timelapse video made in Rio de Janeiro with a medium format camera. A 10K resolution beast.
Finally, let's travel with Scientifantastic to Iceland and Greenland.
You can follow scientifantastic's work in his website www.scientifantastic.com


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http://jessalynking.com/wp-content/uploads/2015/02/logo.png 0 0 jessalyn http://jessalynking.com/wp-content/uploads/2015/02/logo.png jessalyn2017-10-30 20:16:232017-10-30 20:37:22Update
Hi folks, it's been a long time since I've actually posted anything here… but I've been doing stuff!
I'm moving into brand strategy and planning, so I can help you better strategize your brand within your marketing plan. I've worked on many projects, including logos, booklets, books, and trade-show graphics, and upped my networking game!
I'm also looking for help in my sales and new-client acquisition. I'm making a separate post about it, but if you know anyone, have them contact me to apply.


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This page allows you to easily look up the results of any league or cup game since the start of the 2009 season.
We now have ten years worth of results stored online.
Use this archive section to search through these results to see how specific teams performed in previous seasons.
This is certain to save you time compared to searching through old paperwork!
Control Options
To improve the speed of this archive, the games have been split out per season.
The page shows the 2018-2019 season. You can change this by selecting from the menu.
How to use the below chart
You can relist any column (A-Z or 1-99) by clicking on the up/down arrows in the green title row.
Use the search box (top right of the table) to enter a team name (no spaces). This will make it easier to find specific team games.
Teams / Alleys with similar names
Some teams have similar names, which causes problems with the search facility. Because of this, three team names follow a slightly different format:
Somerford Show are listed as Somerford-Show (with a hyphen) to avoid confusion with SomerfordShower.
Startley Wanderers are listed as StartleyWands to avoid confusion with Wanderers.
Vics Rebels are listed as VicsRebs to avoid confusion with Rebels.
More help and tips on search and sorting functions


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I'm a hands on designer and industry leader with over 20 years and building and shipping products, brands and experiences seen by millions for companies like Zynga, Mozilla, Instagram, and Twitter.
I'm a design leader, creative director, advisor and educator with over 20 years experience working for startups and Fortune 500 companies leading brand, marketing, and product executions. My recent client list includes Twitter, Mozilla, NerdWallet, and Thumbtack. I have Master's degree from NYU in the field of Human Computer Interaction and have been both a hands on practitioner and manager throughout my career. If you work with me you will get someone who is passionate employing design fundamentals and strategic thinking to drive results.


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Editor's Choice - May 29, 2012 Daily Top 3 - May 29, 2012
Red Dress Cake, +/- 80cm in height.
Tags: dress cake birthday
20 Comments
Wow, that is some cake
Very nice!
WOW! Lovely.
Wow! unusual and very pretty.
wow! Wow! WOW! Wonderful! Very realistic!
AMAZING!! I love it!
Thanks for the stunning comments everyone!
PLEASE go & vote for this cake on Sweetopia's website! Im in the finals! YEAH! :)
STUNNING…love this cake!
Had to convince my daughter that this was cake…she thought it was a dress I was looking at for her! Really beautiful job!
Maggi I love the dress cakes they are fabulous——wouldn't know where to begin on them
Wow!!! Stunning, i <3 it.


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It is with great pleasure that Amy Jung welcomes you to her site and the US Virgin Islands. With years of experience in the market, she knows how crucial it is to listen to your needs and help you get the outcome you desire. Amy has a proven track record of success and has made many friends during transactions just like yours. Her dedication and perseverance are next to none.
Our personal values inspire our actions and decisions.
We live these values every day:
Celebrate life
Pursue Growth and Learning
Support our Community
Communicate with Honesty
Be kind
Make each transaction a pleasant experience
Create an atmosphere of mindfulness
Remembering to be Thankful
Send her an email at firstname.lastname@example.com or give her a call 214-517-9441 and find out why so many choose Amy above the rest.


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Last week, I gave you my thoughts on the excellent miniseries Torchwood: Children of Earth. Now it's your turn to tell me what you thought of the first night. I'm particularly curious what Torchwood fans thought of it, since (1) I'm not one and (2) I've heard (and written) so much about its appeal to non-fans that I wonder if fans notice much difference from the tone of the series.
Tell me what you think, but no need to repeat it in unison. That gets kind of creepy.


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X chromosome dosage compensation is required for male viability in Drosophila. Dosage compensation relative to autosomes is two-fold, but this is likely to be due to a combination of homeostatic gene-by-gene regulation and chromosome-wide regulation. We have baseline values for gene-by-gene dosage compensation on autosomes, but not for the X chromosome. Given the evolutionary history of sex chromosomes, these baseline values could differ. We used a series of deficiencies on the X and autosomes, along with mutations in the sex-determination gene transformer-2, to carefully measure the sex-independent X-chromosome response to gene dosage in adult heads by RNA sequencing. We observed modest and indistinguishable dosage compensation for both X chromosome and autosome genes, suggesting that the X chromosome is neither inherently more robust nor sensitive to dosage change.
- segmental aneuploidy
- sex determination
- dosage compensation
- sex chromosomes
- gene expression
- genetics of sex
Like in many eukaryotes, reduction of gene dosage is deleterious in Drosophila melanogaster. Multi-locus deletions (deficiencies) are tolerated when the extent of the deletion is modest, but when >1% of genome is hemizygous, the result is reduced viability regardless of which part of the genome is deleted (Lindsley et al. 1972) . The X chromosome in males is an exception to this rule.
The sex chromosome dosage problem is inherent in the evolution of sex chromosomes, an event that has occurred many times during the course of evolution (Larsson and Meller 2006; Vicoso and Charlesworth 2006; Gurbich and Bachtrog 2008; Stenberg and Larsson 2011) . The initial signal for sex determination in Drosophila is the number of X chromosomes (Erickson and Quintero 2007), which results in males being hemizygous for ∼20% of the genome. X chromosome dosage compensation prevents male lethality by equalizing the expression level of genes on the X chromosome in males to that in females to maintain genic balance with the autosomes in both sexes (Parisi et al. 2003; Gupta et al. 2006; Sturgill et al. 2007; Deng et al. 2011). Chromosome-wide X-chromosome dosage compensation relative to autosomes requires the male-specific lethal (MSL) complex (Meller and Kuroda 2002; Hamada et al. 2005; Deng and Meller 2006; Zhang et al. 2010; Georgiev et al. 2011; Stenberg and Larsson 2011).
It is less clear how much of the X chromosome dosage compensation is due to chromosome-wide regulation and how much is due to gene-by-gene dosage responses. For example, there are X chromosome genes that do not show MSL association but that do show dosage compensation (Philip and Stenberg 2013), and some X chromosome genes are dosage compensated very early, prior to activation of the MSL system (Lott et al. 2011). Finally, removal of the MSL complex components does not result in halving of X chromosome gene expression relative to autosomes (Hamada et al. 2005; Deng and Meller 2006; Zhang et al. 2010), raising the possibility that other MSL-independent mechanisms may also contribute to dosage compensation in fly somatic cells.
A priori, an X-chromosome-wide mechanism does not need to result in a precise two-fold upregulation of gene expression relative to autosomes, because even autosomal genes can show some dosage compensation. In Drosophila S2 cells, the observed autosomal dosage compensation level was roughly equal to the approximately 1.4-fold "missing" compensation following MSL complex knockdown, suggesting that there may be an essentially additive effect of MSL and general dosage compensation mechanisms (Zhang et al. 2010). However, other Drosophila cell lines show a variety of global dosage compensation levels (Lee et al. 2014), raising the distinct possibility that this additive effect in S2 cells is coincidence.
Several studies have reported the transcriptional effect of systematically manipulating autosomal gene dosage (Gupta et al. 2006; Stenberg et al. 2009; Stenberg and Larsson 2011; Malone et al. 2012). These studies suggest that the same type of gene regulation that modulates levels in transcriptional networks results in gene-by-gene dosage compensation (Malone et al. 2012; Chen et al. 2014; Lee et al. 2014). This gene-by-gene response also highlights the need to use a matched sample for baseline measurements of dosage compensation. Simply comparing autosomes to X chromosomes is misleading when individual genes differ in dosage responses and when the population of genes residing on the X is highly biased due to the evolution of sex chromosomes (Vicoso and Charlesworth 2006; Gurbich and Bachtrog 2008). If X chromosomes were like autosomes, gene-by-gene responses at subsets of genes should not require specialized factors to achieve dosage compensation (dosage compensation of such genes would result in overexpression), and in other subsets where gene expression collapses in response to a 50% dosage reduction even a two-fold effect might not be sufficient (Malone et al. 2012). However, a host of studies have shown that the X chromosome is quite different than autosomes (Vicoso and Charlesworth 2006; Gurbich and Bachtrog 2008), showing a distinct chromatin signature even in females, for example (Zhang and Oliver 2010). As another example, there is also strong gene traffic off the X in the genus, which could drive dosage-sensitive genes off the X (Sturgill et al. 2007; Vibranovski et al. 2009). The gradual acquisition of dosage compensation during sex chromosome evolution could make the X either more or less sensitive to gene dosage changes, depending on which forces are dominant. For example, a long history of chromosome-wide regulation in males could reduce endogenous gene-by-gene dosage compensation by relaxing feedback in gene regulation networks, whereas in contrast a long history of pressure to increase expression of hemizygous genes on the X before acquisition of chromosome-wide dosage compensation mechanisms could boost these same gene-by-gene regulatory mechanisms. Thus, it is unclear if X chromosome gene-by-gene dosage responses are similar to autosomal gene-by-gene responses.
In wild-type flies, sexual identity, sex-biased expression, and any special evolved features of the X chromosome are confounding factors if you are interested in what could be very subtle effects on dosage compensation. In this study, we separated these factors using autosomal and X-linked deficiencies in conjunction with sex transformation, and we further reduced confounding by restricting our analysis to heads, which show limited sex-biased expression. We performed next-generation RNA sequencing (RNA-seq) and determined expression of matched hemizygous and homozgyous genes to avoid comparing expression of X chromosomes to autosomal genes directly. We observed indistinguishable dosage responses of chromosomes X and 3L in this study, suggesting that X and autosomes have similar overall responses to dosage.
Materials and Methods
Samples and sequencing
We used congenic Drosophila strains from the European Drosophila deletion collection (DrosDel) project (Ryder et al. 2007; Cook et al. 2010) to assay expression changes due to gene dosage. In addition to the DrosDel lines, we examined expression in the w1118 DrosDel parental line and used a Dp(1;Y)BS; cn1 tra2B bw1/CyO and Df(2R)trix/CyO stocks for sex-transforming flies (Bloomington Drosophila Stock Center, Bloomington, IN). We also used OreR (gift from Elissa Lei, Laboratory of Cellular and Developmental Biology, NIDDK, NIH, Bethesda, Maryland). Flies were grown at 25° on San Diego Stock Center cornmeal media. We collected 30 5-d-old adult flies for each triplicate of 10 heads, which were dissected on dry ice and stored at −80°.
We homogenized frozen heads in 2 ml Axygen 96-well plates (Corning, Life Sciences, Union City, CA) preloaded with 200 µL 1-mm glass beads (Biospec Products Inc., Bartlesville, OK) and 200 µL RLT Buffer (Qiagen, Valencia, CA) and covered with Axygen sealing mats, in a Mini-BeadBeater 96 (Biospec Products Inc., Bartlesville, OK). We extracted total RNA with the RNeasy 96 Kit and QIAvac 96 vacuum manifold (Qiagen, Valencia, CA). We visually inspected RNA quality by gel electrophoresis detected with SYbrGold Nucleic Acid Gel Stain and we used a plate reader to quantify yield with Quant-iT RiboGreen (Life Technologies, Grand Island, NY). We used 100 ng of total RNA and the TruSeq RNA Sample Preparation V2 protocol (Illumina Inc., San Diego, CA) to make RNA-seq libraries from polyA+ RNA. We added 10 pg of pool 78A ERCC spike-in RNAs (Jiang et al. 2011) to the Elute, Prime, and Fragment Mix in the "Purify and fragment mRNA" step. We checked the library quality with the High-Sensitivity DNA Analysis Kit on a Bioanalyzer (Agilent, Santa Clara, CA) and concentration by Quant-iT PicoGreen (Life Technologies, Grand Island, NY), and performed 76nt single-end sequencing on an Illumina HiSequation 2000 running CASAVA-1.8.2/RTA 184.108.40.206/HiSeq Control Software 220.127.116.11 (Illumina Inc., San Diego, CA).
Sequence mapping and quantification
To measure expression genome-wide, we performed single-end RNA-Seq on poly-A+ RNA extracted from adult female and male heads in biological triplicate. We uniquely mapped reads to FlyBase genome release 5.57 (St. Pierre et al. 2014) and spike-in RNAs (Jiang et al. 2011) that we added to the libraries to empirically determine sampling variance in complex mixtures of RNA species. We used DESeq2 (Anders et al. 2015) normalized read counts and cufflinks (Trapnell et al. 2012) fragments per kilobase per million mapped reads (FPKM) to report gene-level steady-state expression.
We downloaded GFF3 gene annotation files from NCBI (http://www.ncbi.nlm.nih.gov/), extracted CDS and exon features on existing chromosomes (excluding chromosome U and Uextra), and converted to GTF format, which is compatible with all analysis tools we used, using a custom Perl script. Some peculiar gene features were incompatible with analysis tools. We "corrected" the boundaries of 10 CDS, which were beyond that of the parent genes and changed strand information for 9 CDS (11 exons) according to the annotation of the parent genes. We also added 96 ERCC spike-in annotations in the final GTF file. We mapped RNA reads with Tophat v2.0.10 (Kim et al. 2013). We used parameter −g 1 to retain only uniquely mapped reads and provided the GTF format annotation.
We measured the gene expression using cufflinks v2.1.1 (Trapnell et al. 2012) in fragments per kilobase of transcript per million mapped reads (FPKM). We measured gene expression using HT-Seq v0.5.4p1 (Anders et al. 2015), which reports in read counts. We normalized read counts using DESeq2 v1.6.3 (Love et al. 2014) in R v3.1.1. We used coefficient of variance for genes, intergenic space, and spike-in RNAs to derive a low expression cut-off value (see below).
We generated 264 samples for RNA-Seq profiling with a median of ∼8 million uniquely mapped reads per sample (Table 1). We failed 15 samples during library or sequencing quality checks. We also ensured that the lines still bore the originally generated deletions. Previously, we found that when a Df/+ line did not alter gene expression in the hemizygous segment, there was no Df in the source stock as measured by DNA-Seq (Malone et al. 2012). Therefore, we scanned the gene expression ratios of each Df/+ sample relative to +/+ controls across chromosomes 3L and X. We suspected that Df(3L)4685 was not a deficiency based on this criterion and cytological examination also failed to show evidence of a deletion (K. Cook, personal communication). We removed nine "Df(3L)4685" samples as well as five samples without replicates from the analysis. These data are still useful for other purposes. Data from all 249 high-quality samples are available at the Gene Expression Omnibus (GEO) (Barrett and Edgar 2006) under accession GSE60571. Triplicates showed excellent linear correlations (Figure 1A), giving us confidence in measuring subtle differences in gene expression.
Although RNA-seq gene expression measurements show excellent correlations, understanding dosage responses and compensation requires precision at less than two-fold differential expression. Low abundance transcripts are difficult to accurately quantify, because noise and sampling errors are more pronounced for genes with low expression (Jiang et al. 2011; Malone and Oliver 2011). These factors can confound dosage analysis by suggesting dosage compensation where none exists (taken to an extreme, a gene that is not expressed could be said to be perfectly dosage compensated).
To rigorously avoid overcalling compensation due to low expression, we directly modeled error profiles by comparing intergenic gene expression to genic expression. Although there may be unannotated genes in intergenic space, signal from these regions may also represent biological noise and/or DNA contamination in RNA preparations (Zhang et al. 2010). We also analyzed quantification variance for the synthetic spike-in RNAs with known input concentrations as determined by mass spectrophotometry (Jiang et al. 2011). For intergenic regions (Figure 1B), we found that 95% of intergenic regions had a coefficient of variance (CV) >36 for fold differences. At this CV value, the normalized read counts of external RNA standards fitted with a local polynomial regression was six normalized read counts (Figure 1C). Sixty-four percent of all genes were expressed at more than six, and 69% showed CVs <36. Therefore, we used six normalized read counts as a low-expression cut-off for ratiometric analysis.
Gene expression in wild-type and sex-transformed heads
Sex-biased expression complicates the analysis of the subtle changes in gene expression between XX and XY flies. Therefore, we restricted our expression analysis to heads, because previous RNA-seq experiments revealed relatively limited sex-biased expression in this body part (Sturgill et al. 2013). As an additional measure to reduce sex-biased expression, we transformed XX females into somatic males (Figure 2A) using transformer-2 alleles (tra2Df/tra2B) (Mattox and Baker 1991). When we compared the expression profiles of wild-type female (w1118/w1118) and male flies (w1118/Y) (Figure 2B), we observed a tight overall correlation between the head expression profiles. However, we did observe 670 genes with significantly female-biased and 602 with male-biased expression (FDR-corrected P < 0.05) in wild-type heads (Figure 2B, Supporting Information, File S1). When we compared gene expression in XX females transformed into males (w1118/w1118; tra2Df/tra2B) relative to XY males with tra2 mutations (w1118/Y; tra2Df/tra2B), we only observed 78 genes with significant XX-biased and 34 with XY-biased expression (Figure 2C, File S1). As expected, sex differences regulated upstream of tra2, such as expression of the dosage compensation transcripts encoded by roX1 and roX2, remained XY-biased, whereas genes known to be regulated downstream of tra2 (Salz and Erickson 2010), such as the three Yolk protein genes (Clough et al. 2014), were lowered to male levels in XX; tra2Df/tra2B flies (Figure 2, B and C).
Gene expression by chromosome and gene dosage
If the X chromosome is inherently less or more sensitive to gene dosage reduction than autosomes, then we should observe differences between the dosage responses of chromosome X and 3L in XX females and in XX females transformed into males. To generate these hemizygous segments on the X and autosomes, we chose 12 deficiencies (Dfs) on chromosome 3L as controls and 22 Dfs on the X chromosome (Figure 2D). To avoid any potential bias associated with a particular chromosomal location, we selected a distribution along the length of the chromosome arms. We also avoided deletions reducing the dosage of genes known to be involved in dosage compensation or sex determination, because these could also confound our baseline measurements. Although it is possible that relatively small deletions show different dosage responses than whole chromosomes, we observed no correlation between Df extent and compensation level (not shown), as previously reported for the chromosome arm 2L (Malone et al. 2012).
We first looked at expression genome-wide in the samples parsed by chromosome arm with expression of hemizygous genes from Df/+ chromosome regions binned separately (Figure 3, A–C). This analysis showed a strong bias for higher expression levels for chromosomes X and 4 genes in the regions of the genome with wild-type gene content. Chromosome 2L showed reduced overall expression in heads. This gene-content uncorrected analysis also showed essentially no compensation for X chromosome genes and a collapse in the expression of hemizygous genes on chromosome 3L. At face value, these observations show clear differences in baseline compensation between the X chromosome and the autosomes.
However, expression variance by linkage and by sampled region could also be due to differing chromosome and/or regional gene content as a confounding factor for analyzing dosage effects. For example, when we simply examined expression levels, median chromosome 2L expression was lower than expression hemizygous genes in Df/+ regions on the X chromosome. These overall expression levels were essentially the reciprocal of the gene expression bias in reproductive tissues (Parisi et al. 2003; Sturgill et al. 2007), suggesting that different gene content, not dosage responses per se, are responsible. Specifically, there is under-representation of genes with male-biased expression in reproductive tissues on the X chromosome and fourth chromosome, and we show over-representation of genes expressed in heads on these chromosomes. Given that chromosome 4 is derived from an ancient X (Vicoso and Bachtrog 2013), these data suggest selection favors X linkage for genes expressed at high levels in heads. This is reminiscent of mammals where genes highly expressed in the brain are preferentially X chromosome–linked (Vallender and Lahn 2004). Reciprocally, there is an over-representation of genes with male-biased gene expression on chromosome 2L, and we show depletion for genes with high expression in heads on 2L. For our purpose here, sex-biased content is a confounding factor that hinders comparison of X chromosome expression levels with those of the autosomes.
Comparing the expression of the same genes when present in different copy number eliminates the effect of gene content differences (Figure 3, D–F). When we examined expression of a given gene when hemizygous, compared to the median expression of that gene in all lines (by bootstrapping), we observed a much more consistent dosage response, characterized by a strong decrease in median expression, with a median compensation level of ∼1.1-fold, in the case of both Dfs of chromosomes X and 3L. In both XX females and XX females transformed into males, the expression of hemizygous X chromosome and autosome genes was not significantly different, and there was not even evidence of a trend (Figure 3E). In XY males, X chromosome compensation was not significantly different from perfect, whereas compensation of autosomal hemizygosity was similar to that observed in XX fly heads (Figure 3F). These data indicate that the X chromosome has a generic response to decreased gene dosage that is similar to that of the autosomes.
Drosophila melanogaster sex chromosomes are thought to have arisen from an autosome pair and diverged to the current state by the gradual loss of genes on the nonrecombining Y chromosome (Vicoso and Charlesworth 2006). With the loss of more and more genes from Y chromosome, the chromosome-wide dosage compensation mechanism evolved as an effective machine for balancing X chromosome gene expression in flies with a highly degenerate Y chromosome. According to theory, the initial compensation for the one-dose genes on proto-X should be the same as the autosomal ancestor, which we suggest is the ∼1.1-fold upregulation we observed in this study. If the X chromosome became hemizygous little by little rather than all at once (Marin et al. 2000), then this might have provided time for selection to strengthened transcriptional regulatory interactions either before or during the emergence of the chromosome-wide compensation system. Additionally, the evolution of X chromosomes with a gradually degenerating Y chromosome should result in selection against chromosome-wide dosage compensation when the Y is young due to deleterious overexpression of genes with functional alleles on both the X and Y chromosomes. This shifting selection during the course of X chromosome evolution might result in strengthened compensation or selection for gene content that favors X-linkage for genes with more robust gene regulation. We found very little evidence for inherent differences between X and autosome compensation, suggesting that the extant X has the same inherent dosage response as an autosome. This is somewhat surprising given that the X chromosome shows a specialized chromatin structure in females and males (Zhang and Oliver 2010; Lee et al. 2014) and responds differently to gene dosage balance in trans (Sun et al. 2013), in addition to the evolutionary history outlined above.
The generic response observed for the X and autosomes is consistent with gene regulation playing a role in the response to copy number. For any given gene, we observed a significant correlation in compensation values among female, male, and sex-transformed flies bearing the same Dfs (not shown), supporting the idea that inherent gene-specific compensation levels contribute to the general dosage response (Malone et al. 2012). This includes evidence for additive effects of generic and chromosome-wide regulation (genes with the best compensation in Df/X flies tend to be overcompensated in XY flies), as previously reported in S2 cells (Zhang et al. 2010). We found median compensation (1.1-fold) at the low end of the previously reported range (1.1- to 1.8-fold) for partial compensation in Drosophila adults and cell lines (Johansson et al. 2007; Stenberg et al. 2009; McAnally and Yampolsky 2010; Zhang et al. 2010; Lundberg et al. 2012; Malone et al. 2012). Many of the differences in compensation values in these studies are due to low expression cutoff decisions. Increasing the cutoff values in the previous datasets also results in lower compensation values and decreasing the low expression cutoff values increased median compensation values in the dataset reported here (not shown). Thus, either there is better compensation of genes with low expression (Stenberg et al. 2009; Malone et al. 2012) or there is data compression due to expression noise and nonlinearity at low expression levels (Malone and Oliver 2011; Wang et al. 2014), or both. Additionally, reanalysis of cell line RNA-Seq datasets using more conservative low expression cutoffs, newer short-read aligners, and copy number callers (Boeva et al. 2012; Langmead and Salzberg 2012; Kim et al. 2013) showed consistent partial compensation ≤1.2-fold in most cell lines (H. Lee and B. Oliver, unpublished data). Human HeLa cells also show ∼1.2-fold compensation (Landry et al. 2013). However, even within a study with common methods and data handling, there are unexplained outliers (Lee et al. 2014). This highlights the importance of using carefully matched experimental and control biological samples and careful consideration of data handling in the analysis of dosage compensation. Given that X chromosome dosage compensation is very close to two-fold, whereas the effect of MSL mutations and gain-of-function are not, and given that the X does not appear to show boosted gene-by-gene compensation, then a substantial amount of X chromosome dosage compensation remains unexplained.
We thank Harold Smith for sequencing, Hangnoh Lee for reanalysis of published data, Kevin Cook for Df cytology, Helix (http://helix.nih.gov) and Biowulf (http://biowulf.nih.gov) for providing high-performance computational capabilities, FlyBase for files, and our lab for stimulating discussions. We also thank the Bloomington Stock Center and Elissa Lei for fly lines. The Intramural Research Program of the National Institutes of Health, NIDDK (ZIA-DK015600), supported this research.
Supporting information is available online at www.g3journal.org/lookup/suppl/doi:10.1534/g3.115.017632/-/DC1
Data accessions: GEO GSE60571.
Reviewer link: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?token=cdsnskcehhmzvsl&acc=GSE60571.
Communicating editor: J. A. Birchler
- Received January 30, 2015.
- Accepted March 26, 2015.
- Copyright © 2015 Chen and Oliver
This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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1) Bastard; 2) You To Thank; 3) Jesusland; 4) Landed; 5) Gracie; 6) Trusted; 7) Give Judy My Notice; 8) Late; 9) Sentimental Guy; 10) Time; 11) Prison Food.
The album sleeve photo is so outrageously generic-hipster here that there are only three choices from the outset: either the music is going to be suitably generic boring trash, or it is going to be a masterpiece of self-parody, or it is simply going to be a masterpiece, because there's really no way that album sleeve photo could be anything but a sarcastic ruse. The third choice seems like the unlikeliest of the three — but give Songs For Silverman a few attentive listens, and you just might start veering towards No. 3 all the same.
My own first listen was a complete disaster: the only thing I understood was that the album consisted exclusively of sentimental / melancholic ballads, nary a bouncy, rhythmic pop hook in sight, let alone any possibilities of «rocking out», and that kind of monotonousness would be hard to take even from a certified genius like Paul (even before he stopped eating meat) or Elton (even before he sold all his costumes). There were no new attitudes or approaches, either, though it did look as if he took a few extra singing lessons; and the instrumentation, once again, was completely dominated by solo piano, with sparsely scattered guitar or string overdubs passing by unnoticed unless you were really paying attention.
The situation only changed by the third time, when the music sank in a little bit and started dissolving the major prejudice — namely, the one that Ben Folds is a good pop hook provider and a funny maniac on stage, but a generally rotten troubadour. The particular song that did it to me was ʽLanded' (and a good choice for first single from the album it was, too, even though it did not manage to get too high on the charts). Relatively simple lyrical message of transgression and redemption — but what a terrific musical build-up, from the quavering vocal of the verse aided in becoming decisive by the sharp piano chords, and right up to the "bye-bye goodbye" hook of the chorus: a well-placed falsetto note or two can work wonders, but only if it is well-placed, and I think this one deserves an A+ for well-placing.
Then there was ʽTime' — normally, I'd suggest that artists that still go on writing songs named ʽTime' should be lined up against the wall, but this one actually happens to deserve its own place of honor somewhat below, but not light-years-far-from Pink Floyd's, Bowie's, or Alan Parsons', and again, much of this has to do with the unbeatable falsetto hook, indeed delivered by Ben Folds himself, even if he is being vocally assisted on the song by none other than Weird Al Yankovic, for some reason. Not that there's anything weird about the song itself — it is just a mid-tempo adult contemporary ballad with complexly layered backing vocals, but the drama is so masterfully executed, mainly through the contrast between "in time I will fade away, in time I won't hear what you say, in time..." (strong, self-assured bit) and "...but time takes time you know" — this time, the falsetto actually means "PANIC!".
These two songs served as the anchor for testing a hypothesis — what if Songs For Silverman is actually a confessional masterpiece, Ben's own Plastic Ono Band, or Blue, or Blood On The Tracks, any of those things? For that matter, he would only divorce his third wife, Frally Hynes, in November 2006, but it is quite likely that things were flying out of control much earlier already, and considering how many ladies ultimately failed to satisfy the man (he seems to be taking his cue here from big idol Billy Joel), it might be argued that Ben Folds marries and divorces mainly for the sake of getting fresh inspiration for his material. And indeed, other than the first track and ʽJesusland', just about everything here is about being alone once again and trying to find different ways to deal with the trauma, either by remembering, or by forgetting. But that is not important per se — the really important thing is, should we care?
I think that songs like ʽLanded' and ʽTime' provide ample evidence that we should. Yes, he may be building here on the same territory that had already refused to yield to him several times earlier, but he's either been taking songwriting lessons (next to singing ones) or perhaps the feelings just got sharper, so that much — far from all, but much of the album — really cuts hard, and should be well recommendable for all non-suicidal loners who want to heal rather than hurt, or, at least, use the hurt for healing purposes.
It's really a brief conceptual travelog here. We begin with some general morals ("why you gotta act like you know when you don't know?") as a basic framework (ʽBastard'), start off at the far away beginning when things were good and connecting (ʽYou To Thank', although the song is already permeated with sadness, so you know it's not going to be all that happy from now on), take a sideways stroll to think about the futility of religion (ʽJesusland'), patch up our first batch of differences (ʽLanded'), and raise our little kid (ʽGracie' — quite a charming little ballad to Ben's daughter). That's the «still-okay» part of the business.
As we go to Side B, we discover that she's been reading our secret diary (ʽTrusted'), declare that "I won't be your bitch anymore" (ʽGive Judy My Notice'), take another sideways stroll to say a few words in memory of the recently departed Elliott Smith (ʽLate' — but thematically, with its mournful farewell mood, the song fits in perfectly), share a few last thoughts on how we used to be so similar, but the different has won out all the same (ʽSentimental Guy'), make the transition to spiteful bitterness in relations (ʽTime'), and wrap it up with a grand finale (ʽPrison Food') where Ben's quiet wailing ("alone, alone again!") is enveloped in frantically thrown layers of percussion, piano, and steel guitar, as if the idea was to create something on the scale of ʽLove Reign O'er Me'. Of course, that sort of scale is quite out of reach, but a humble approximation is quite possible, and if ʽPrison Food' will not be able to make you feel sorry for the man, then you are probably immune to Ben Folds as an organic character in general.
Some of these songs are worse than others, but the fact that it all ties up so nicely kind of levels everything up: the highlights never cease to be highlights, and the lowlights, whatever they be, are still moody enough to fit the concept. The only thing that does not fit is the title of the album — which, for that matter, was going to be dedicated to Ben's representative at Sony (Ben Goldman), but, for reasons of confidentiality, «Goldman» ultimately got split into «Silverman» and «Goldfish» (for the accompanying live record). That, like the album photo, should be regarded as a proverbial red herring, because the personal experiences of Ben Goldman have nothing to do with the personal experiences of Ben Folds, or with the status of this album as the ultimate breakup record of... well, let's say, of the year 2005, since, after all, breaking up seems to be the quintessential Significant Artistic Topic of the 21st century, families not being what they used to be and all that. Anyway, a hefty thumbs up, of course.
Check "Songs For Silverman" (CD) on Amazon
Check "Songs For Silverman" (MP3) on Amazon


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The closing date for applications is 07‑08‑2018
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Related documentsPAC Statement S067 Application form.pdf SCHEDULE 1C Article 2D - letter to Consultants.pdf English Site notice.pdf Welsh Site notice.pdf Letter to residents.pdf TT2255-Bronllys Hall-L03-Bat Letter Report-Rev00.pdf Drawing Issue Sheet.pdf S067.1.3.03 Existing Basement Plan.pdf S067.1.3.04 Existing GF Plan.pdf S067.1.3.05 Existing FF Plan.pdf S067.1.3.06 Existing SF Plan.pdf S067.1.3.07 A Existing Elevations 1.pdf S067.1.3.09 Exisiting Coach House Plans.pdf S067.1.3.10 Exisiting Coach House Elevations.pdf S067.1.3.11 A Existing Gardener's cottage elevations.pdf S067.1.3.12 B Demolition Site Plan.pdf S067.1.3.14 Existing Gardener's cottage plans.pdf S067.2.1.00 Block Plan.pdf S067.2.2.01 Location Plan.pdf S067.2.3.110 B Proposed Basement plan.pdf S067.2.3.111 D Proposed GF plan.pdf S067.2.3.112 C Proposed FF plan.pdf S067.2.3.113 B Proposed SF plan.pdf S067.2.3.114 D Proposed Elevations 1.pdf S067.2.3.115 A Proposed Elevations 2.pdf S067.2.3.118 D Proposed Site Plan.pdf S067.2.3.119 A Proposed Mews Accommodation Plans.pdf S067.2.3.120 A Proposed Mews Accommodation Elevations.pdf S067.2.3.121 A Proposed Mews Accommodation Elevations.pdf S067.2.3.124 B New Access.pdf S067.2.3.126 A Educational Facility Plans.pdf S067.2.3.127 A Educational Facility Elevations.pdf S067.2.3.128 A Educational Facility Site Plan.pdf S067.2.3.129 A Gardener's Cottage Proposed Plans.pdf S067.2.3.130 A Gardener's Cottage Proposed Elevations.pdf S067.2.3.132 Existing Site Plan.pdf S067.2.3.133 Proposed Site Plan.pdf
Pre-planning consultation at Bronllys Hall, Bronllys, Powys, LD3 0LS
A pre-planning consultation is being undertaken for the conversion and alterations from existing offices to a hotel, conference and private event venue. at Bronllys Hall, Bronllys, Powys, LD3 OLS.
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Had a miserable nite, got up feeling like i had had a beating. I'm never gonna stay here and wait again. J got the MRI done, not sure when he'll hear from it. It was being sent to his doc then.
Heat's here til the weekend. And i think we still have that African dust too. Just saw on FB where my G/dotter's ac is out. Never fails to do that in the worst of the summer. Not sure if it's fixable or not.,,,Surely it is.
You either watch Olympics or turn the tv off. Mine's off. Just need the quiet sometimes. Fixing to eat some oatmeal, maybe nap a little, and read. Almost thru with my book.
Yall tc, and


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I Was Stabbed by Sweet Tooth and All I Got Were These Stupid Pictures!
Tuesday, February 7, 2012 Leave a comment
Living in the Bay Area is pretty nice. We're very close to three major cities, meaning there is ALWAYS some sort of event going on at any given time. You can also make the case that the Bay is the Mecca of video games. With such studios as Sony Computer Entertainment America, Visceral Games, 2K Marin, and Capcom (to name a few) taking residence here, you can pretty much guarantee that there will be some awesome events put on by these companies. One such event took place on February 2nd, and was put on by Sony. It was a public and media party/tournament for the highly anticipated reboot of the bestselling car-combat franchise Twisted Metal. I've been a fan of the series since I was a young lad, so you bet your ass I went. It was a ton of fun, and it only made me want the game even more.


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Meet Allegiant!
Allegiant came to the Liberty Nature Center in July 2014. She is now a part of our education collection. To read Allegiant's full story,
click here.
Directions from South HWY 27/ 914 Bypass intersection:
The Liberty Nature Center is currently off season and
is open to the public by appointment only.
You can set up a tour of our facilities via the tour request form below or by calling 606-679-WILD(9453).
Hours of Operation
Tuesday - Saturday 10:00am - 6:00pm
Closed to public on Monday and Sunday
We ask for a small donation of $5 per person over the age of 2.
Call for appointment.
If you have a wildlife emergency and are dropping an animal off, please call 606-219-1450 or 859-492-6183.
Have a Wildlife Emergency?
Call: 606-679-WILD (9453)
Tour Request Form:


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At Intec we want you to get off to the best possible start
in your new career. In this section of our website we have provided some
resources and support materials that can help in the work place'
Intec Business Colleges Ltd, Old School, Pennington Court, Rugby, Warwickshire, CV21 2BB. UK. Company Number: 2494959
Privacy Policy. Copyright Intec Business Colleges Ltd 2020. Website Design By Zarr


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WASHINGTON (Reuters) - The U.S. government said on Monday it was holding firm to its recommendations that pregnant and breast-feeding women limit how much fish and other seafood they eat and avoid certain types with high levels of mercury.
The two agencies that have set government policy on the subject — the Food and Drug Administration and the Environmental Protection Agency — have declined to alter their recommendations that these women eat no more than 12 ounces of fish weekly.
Their stance comes a week after a health advocacy coalition that received funding from the fish industry and 14 experts on October 4 urged these women to eat more fish.
The U.S. Centers for Disease Control and Prevention and other government agencies that are members of the National Healthy Mothers, Healthy Babies Coalition have actively distanced themselves from the coalition's new advice.
Some environmental activists said the coalition and its experts had tried to mislead women with the recommendations.
The coalition said the nutritional boost for infant brain development and other benefits outweighed any risks from trace amounts of the toxin mercury in fish and seafood — directly contradicting government advice.
The FDA and EPA have advised limits on fish and other seafood consumption because some contain levels of mercury that may harm the developing nervous systems of fetuses and infants.
"The joint EPA/FDA fish consumption advisories are based on sound science, and the agency recommends pregnant women continue to follow the current guidelines," EPA spokeswoman Suzanne Ackerman said by e-mail in response to an inquiry.
FDA spokeswoman Stephanie Kwisnek said the agency also is sticking with its existing recommendations.
Fatty fish and shellfish are rich in omega-3 fatty acids, key for brain development. But they can also contain mercury, which destroys brain and nerve cells.
In March 2004, the FDA and EPA recommended that women who are pregnant, might become pregnant or are breast-feeding eat no more than 12 ounces weekly, two average meals, of types of fish and shellfish lower in mercury.
They advised not eating shark, swordfish, tilefish or king mackerel because they had high levels of mercury.
The coalition, however, said women should eat no less than 12 ounces per week of fish and other seafood including salmon, tuna, sardines and mackerel, saying eating fish is the best way to gain the benefits of omega-3 fatty acids. They did not set an upper limit for how much should be eaten.
Richard Wiles, executive director of the Environmental Working Group, said if women followed this advice there could be an epidemic of mercury poisoning among America's children.
"It's pretty clear that this was nothing but a public relations effort on the part of the fish industry to confuse people about the hazards of mercury and to encourage women to eat the products they sell regardless of how contaminated they are with mercury," Wiles said in a telephone interview.
The CDC, the National Institute of Child Health and Human Development and the Health Resources and Services Administration all said they have collaborated in the past with the coalition but did not endorse or help formulate the new fish consumption advice.
"We continue to support FDA and EPA on their recommendations," CDC spokeswoman Courtney Lenard said.
Judy Meehan, executive director of the National Healthy Mothers, Healthy Babies Coalition, said the National Fisheries Institute, an industry group, gave the coalition $60,000 to help publicize the recommendations and a total of $16,000 more to the 14 outside experts who helped.
Meehan said this funding does not undermine the integrity of the recommendations. "Our position is that fish is critical for brain development. There's a lot of science supporting that," Meehan said in a telephone interview.
Non-fish sources of omega-3 fatty acids include leafy green vegetables, walnuts and flaxseed oil.


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S: Caribbean Cruise
BC: Five days wasn't enough... but i'll be back
FC: By Anna Goldberg
1: Table of Contents 1. Itinerary 2. Journal number 1 3. Port of Call - Barbados 4. Journal number 2 5 .Port of Call - Martinique 6. Journal number 3 7. Port of Call - St.Kitts and Nevis 8. Journal number 4 9. Journal number 5
2: Intineray Day 1 - Get on boat , depart Port of Spain Day 2 - Arrive at Bridgetown in Barbados Day 3 - Arrive at Fort - de - France in Martinique Day 4 - Arrive at Basseterre in St. Kitts and Nevis Day 5 - Depart Basseterre and head back to Port of Spain
3: =Monday March 1, 2011 Today is the big day! I can't believe I've finally made it here. I worked so hard studying and getting all my homework done so I could attend this lovely cruise to the Caribbean. This is my first time on a cruise of any kind and the first time I've been on a cruise ship. It's like being on the Titanic except without the fancy ballrooms, period clothing and much better sanitation. It's around noon time and were leaving from the Port of Spain in Trinidad and Tobago. In nine hours I will be in Bridgetown in Barbados. But until then I'll just spend some well deserved time relaxing in and around the ship. But first let me describe this wonderfully comfortable room, I'm staying in. The bed is so big, queen sized with the fluffiest pillows I've ever seen. There is a personal bathroom, with essential toiletries and a TV and a big dresser to keep my stuff in. I even got my own bathrobe and matching fuzzy slippers. I think I could live in such splendour every day. Well at least for the next five days I will be. The ship has so many people on it , it's overwhelming but the more the merrier I guess. I am so excited to be visiting a couple of countries I've never seen before. This little adventure I am taking will give me an experience of a lifetime that I will probably remember for the rest of my life. Now let me just say one more thing before heading off to explore the ship. The weather is great but what's even better is the food! I've never seen so much food in one place before and the variety is immense! I think I'm going to be enjoying my time a lot on this boat. Well I'm off, I've heard the on board art gallery is something worth checking out, until tomorrow.
4: Bridgetown | Barbados
5: =Tuesday March 2, 2011 What a great day today has been. I went to Barbados and explored this wonderful island. I had always heard great things about this vacation spot. I now know firsthand how sublime this country is. That morning at around 7am I got up and had breakfast and quickly made my way to the city of Bridgetown. I figured I should head over to Broad Street to buy a couple of souvenirs at local stores in this area. Everything there is handcrafted. After buying some Caribbean themed jewellery and interesting little knick knacks, I made my way over to "Harrisons Cave". This probably was the most fascinating place I visited in Barbados. The cave has its own waterfall in it and some artefacts left their but early people's living on the island. The tour guide was knowledgeable and my trip in the cave fun and informative. There was a restaurant carved into the cave. It was interesting to sit and eat in a cave. After I visited the cave a took a short boat ride in a glass bottomed boat, so I could see all the tropical fish swimming by. I loved seeing the fish in their natural environments.
6: Journal Continued I left the boat feeling tired after sitting for awhile, so I decided to go over to "Batts Rock" beach to try windsurfing. I wasn't the greatest at this and I was pretty nervous about doing this type of sport but I persevered to make it through and I thoroughly enjoyed myself. The last thing I did before heading back to the cruise ship was take a short side trip to some of the tide pools to check out these natural mini ecosystems. It was awesome to see little crabs and other marine life all contained in a tiny circular pool where we could look into it and watch. It was a mini world that revealed it mysteries when you looked at it but is completely forgotten when you step away. A perfect end to a great day. Coming back to the ship I was tired and hungry and the ship provided its welcoming comforts.
8: Fort -de - France | Martinique
9: = | Wednesday March 3 2011 Today is the third day of my Caribbean cruise. I just came back from the island of Martinique. From Bridgetown we sailed to Fort-de-France. I am absolutely in love with this island. It has such a refined relaxed feeling. The evident French heritage and culture is all over the island, giving it a unique blend between Caribbean and French culture. I got off the cruise ship and immediately aimed myself in the direction of the Musée Départemental d'Archéologie et de Préhistoire de la Martinique. In this museum I saw the artefacts of early island natives and saw some beautiful looking pottery and other items. . After visiting the museum, I took some time to make my way over to the La Savane, where I viewed some lovely gardens with a statue of the monarch of the island. The island statue had no head because of political strife in the country before; out of rebellion the people beheaded the statue. In this area were some beaches and shops and cafes.
10: Journal Continued The highlight of my day though was seeing the nationally renowned Les Grands Ballets Martiniquais. They were a dance troupe that focuses on the traditional dancing of the island and they were wonderful. The music they danced too had a great beat and their dances were nothing I've ever seem before. My whole day spent on the island of Martinique was a complete and utter joy. I experienced a culture much different than my own and found a lot of interesting places to visit. So far this island has been my favourite so far , getting an equal balance between enjoying their culture , checking out the natural beaches and sunshine to learning about their past and educating myself about this island's history.
12: St.Kitts and Nevis
13: Basseterre
14: Thursday March 4, 2011 Wow the fourth day of my cruise already? It's been a great couple of days so far and I'm super excited to be heading to the island of St. Kitts and Nevis. After setting sail from Fort – de – France in Martinique we sailed for eight hours to the next stop on our cruise. We arrived in the town of Basseterre. It was a warm and sunny day where every person around looked happy to be there. I started my day off by having a great ship breakfast with a buffet of classic breakfast food. It was so delicious and quite filling I then decided that I would go to Brimstone Hill fortress. It was an appropriate choice for me to visit first. I found these old 18th century battle fortifications to be interesting and fun to visit. I had never seen a fortress before or one from the 18th century, so I was pleased to a scene or leave a message to others.
15: Journal Continued Those ancient drawings are a rare sight to see and me being lucky enough to glimpse them has made me greatly enjoy my time spent in the splendid manor home. A quick stop for lunch at a local restaurant had me satisfy my hunger, I was then able to make my way over to Sky Safari Tours, to try my hand at zip lining. It was a nervous but ultimately exhilarating experience that'd never forget. I zipped across the line so fast and high that all the foliage whizzed by me. It was quiet and peaceful all around except for my screams that were ringing out. With my time running out I briskly traveled back to the cruise ship to get back in time for dinner on the ship and take the long ride back to Trinidad and Tobago. It was a fun but exhausting day that had me a little sad that my island adventures were over. I think I'm going to bed now, rest up a little and explore the boat more tomorrow.
16: Ancient church
17: Something is fishy here
20: Friday March 5, 2011 The last day has finally come. My bags are all packed and ready to go. I've quite missed being at home but not as much as I have missed the island sun. It was such a glorious cruise I went on, that not being able to wake everyday and just visit a new place is going to take some getting used to again. All the islands had their own unique charms and customs and not to mention the delicious foods that I got to eat. So much history and cool natural sites I ventured into. Seeing Harrisons cave and zip lining were definitely my most cherished moments. Being out of the ordinary lifestyle back home was a nice change. The lovely warm breeze and salty sea air are what I'll miss the most on the cruise. I found a great on deck music club where you could dance and have fun and a cool art class where they were letting people paint and draw anything they wanted. I swam in the pools and emailed my friends about my awesome trip. I spent as much time I could outside to soak in all the sunshine and by the time I knew it , it was time for bed. So before I head off to sleep, I'll just look at the ocean one last time through my window and dream about all my island memories.


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In the Netherlands, we have a few big cinemas, and Pathé is one of them. Every once in a while, they organize the "PAC Festival", which is basically five previews of movies that are coming out soon (movies always come out "soon"… don't they?).
Now, my mum and I are both lovers of film and she's told me before that they were hosting this. Sadly we were never able to go before because of ~life~. But on Sunday, February 5th, it was finally time. We were going to be locked in the cinema from 10.30am until 11.15pm. Which was really fucking exciting.
The movies they showed were great, and I would like to give a mini review for each one of them so you can decide whether you'd like to see them too.
- Jackie – 7,5/10
"Following the assassination of President John F. Kennedy, First Lady Jacqueline Kennedy fights through grief and trauma to regain her faith, console her children, and define her husband's historic legacy."
Jackie was a very serious and heavy movie. But it was also a very beautiful movie. The cinematography was stunning and the way the movie alternated between past and present was captivating. Natalie Portman's acting is phenomenal, and I totally understand why she would be nominated for an Oscar this year. I do felt that at times, the movie dragged a little bit. It wasn't a particularly long movie (1h 44m), but it felt like it went on for at least 2,5 hours. What did really warm my heart was to see John Hurt's last on screen performance.
- Their Finest – 6,5/10
"A British film crew attempts to boost morale during World War II by making a propaganda film after the Blitzkrieg."
Sam Claflin and Gemma Arterton in a WWII movie? Hell yes. I expected this to be a more serious movie, but it wasn't like that at all. Yes, it deals with rather heavy topics (war, death, cheating), but because of the way it was executed I didn't feel it that way. It was nice to watch, but I don't think it was a great movie. The old-fashioned propaganda film they created in the movie was so much fun to see.
- Mein Blind Date mit dem Leben – 8/10
"An ambitious young man struggles to achieve his dream of becoming an employee in a Munich luxury hotel despite being strongly visually impaired."
I don't watch anything German if I don't have to. It's a Dutch-German thing and I apologize for it. German just isn't a language I enjoy listening to. But THIS MOVIE WAS GREAT. I laughed my ass off and felt thoroughly happy after watching this. The best feel-good movie I've seen in a while. The thing I loved most was the friendship between Saliya (the main character) and Max, whom he meets in the hotel he starts working in. Honestly recommending it if you feel like you need a laugh and happy feels.
- Hidden Figures – 9/10
"The story of a team of African-American women mathematicians who served a vital role in NASA during the early years of the US space program."
You must have heard of Hidden Figures. It's a riveting story about three black women who kick ass at NASA in a time where racial segregation is still a thing. Taraji P. Henson is one of my favourite actresses so I was really excited to see her in this, and boy did she do a good job! But honestly so did Janelle Monáe and Octavia Spencer. All three of them together bring such an amazing sense of humour to the movie, and a big smile was plastered on my face most of the time. The fact that it's based on a true story makes it even more special. It makes me so sad that they had to deal with segregation but it makes me happy that these women did not let it stand in their way to achieving greatness. Theirs is a story that must be told more and seeing this movie is a damn good way to start.
- Gold – 6,5/10
"Kenny Wells, a prospector desperate for a lucky break, teams up with a similarly eager geologist and sets off on a journey to find gold in the uncharted jungle of Indonesia."
Matthew McConaughey delivers a good performance as Kenny Wells, but this role feels like a repetition of some of the roles he's played before lately (e.g. in Dallas Buyers Club, The Wolf of Wallstreet), and it kind of makes me want to see him do something else. It also doesn't help the story, that already isn't very special in my opinion. I did really enjoy Edgar Ramírez's performance as Kenny's "best friend" Michael Acosta. It's a very enjoyable film, just don't get your hopes up too high before seeing it. Special appreciation for the movie poster btw because it's so aesthetically pleasing.
We did it! My mom is usually rather prone to reproduce the famous "How Moms Watch Movies"-meme, but this time SHE DIDN'T! Round of applause, please. We both really enjoyed this film-filled day and hopefully I can make her go with me again next time. Do let me know in the comments if you're planning on seeing any of these movies soon (or if you've already seen any of them) and what your thoughts on them are.


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In the Air tonight
Occasionally you come across a program and you find yourself wondering how you ever lived without it. Airfoil is one of those programs (or at least it is if you have a wireless network with multiple Airports, which I do). Apple's Airtunes is a great feature that lets you stream music from iTunes to speakers connected to any single Airport on your network. The two obvious drawbacks to this is that you can only stream music to a single Airport at any given moment, and that you can only use this function with iTunes.
Here is where Airfoil comes in, it lets you stream to multiple Airports simultaneously, and lets you stream any audio on your computer. This is great for broadcasting internet radio, DVD audio tracks (though as there is a very noticeable lag in the broadcast time you need to use something like VLC to manually synch up the audio and video tracks), or even Skype calls.
So our wonderful new home still has no furniture or curtains, but it has an amazing wireless music system pumping out tunes in every room.
Solid. Tweet


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PASADENA, Calif. — A furious second-half comeback. A 100-yard kickoff return. A touchdown drive led by a redshirt freshman quarterback that ended with 13 seconds on the clock.
That was all it took to end the Southeastern Conference's stranglehold on the Bowl Championship Series trophy. That was what it took for Florida State to out-Auburn the Auburn Tigers in its 34-31 triumph at the Rose Bowl Stadium on Monday night.
The final minutes looked like a wayward polygraph test, the teams flying up the field, the lead flipping back and forth. A full 24 points were scored in the last 4 minutes 42 seconds, otherwise known this season as the time when Auburn normally did something — like catching a tipped Hail Mary pass or returning a missed field goal for a touchdown — to pull off another stunner.
That meant that Auburn had Florida State right where it wanted it late in the fourth quarter. Sure, the Seminoles had unleashed Levonte Whitfield, he of the 4.37 40-yard dash and the Kermit nickname, for a kickoff return that started in the front of the end zone, moved toward the left sideline and ended 100 yards down field. But this was Auburn, the team for whom "insurmountable" means "let's get started."
The Tigers took over with 4:31 left. Auburn time, at least in 2013. In seven plays they moved the ball to Florida State's 37-yard-line. The next handoff went to running back Tre Mason, who sliced up the middle, scooted into the secondary and scored to reclaim the lead, 31-27.
"Felt pretty good," Coach Gus Malzahn said of his team's chances at that point.
Only Auburn made a critical mistake there. It left 1:19 on the clock against Florida State's offense.
That was enough for Jameis Winston, the Heisman Trophy winner who spent the latter part of this season under scrutiny for an accusation of sexual assault. Winston, known as Famous Jameis, more famous than ever now, began the march.
Florida State's drive started on its own 20-yard-line. It stalled on Auburn's 10. On that play, on third down, Winston lobbed a pass into the end zone, and while the toss fell incomplete, it also drew a pass interference penalty on Chris Davis, the Auburn player who returned the missed field goal to beat Alabama.
The penalty extended the drive. The Seminoles avoided a fourth down.
On first-and-goal from the 2, Winston scanned the defense. He later said he knew the instant he looked at Auburn's play call that the Seminoles were going to score.
The receiver that he targeted, Kelvin Benjamin, struck Winston as emotional before the game started. He had tears in his eyes. Then he hauled in the winning touchdown in decidedly Auburn fashion for a 2-yard score and thanked teammates who believed in him. Same as his quarterback.
"I was ready," Winston said. "I wanted to be in that situation."
The Seminoles' victory came in the final B.C.S. championship game. It ended a streak of seven straight B.C.S. titles secured by the SEC, including four straight won by universities from Alabama.
Auburn attempted one final miracle on the final play. But where a tipped desperation pass was completed against Georgia and a missed field goal was returned 109 yards against Alabama, a last-gasp comeback bid on Monday at the Rose Bowl was simply thwarted.
A full 94,208 stood and acknowledged this defibrillator of a football game.
"The A.C.C. is good football, folks," Florida State Coach Jimbo Fisher said, referring to the Atlantic Coast Conference. "I'm happy for the A.C.C. There's some good football played in this conference, too."
The theme before the game centered on destiny versus dominance, or a so-called team of destiny (Auburn) against a dominant one (Florida State), or the best team versus perhaps the hottest one. The catchy alliteration highlighted the stark contrast between these teams — Auburn and its four fourth-quarter comebacks (two of the miracle variety) and how Florida State never trailed after halftime.
Naturally, the expected Seminoles blowout did not materialize, banished to the dominant story-lines graveyard of big games past. Everything else went as planned: John Legend sang the national anthem, fireworks exploded, imaginary tomahawks were chopped.
Then they kicked the ball off, and it was Mason and quarterback Nick Marshall and Auburn's offense that sped down field. Marshall, in fact, could have thrown a deep touchdown on the Tigers' first drive, but his pass, terribly underthrown, fell incomplete.
The Seminoles opened the scoring after the incompletion with a 35-yard field goal from Roberto Aguayo. But this was not the offensive outburst expected from two teams that averaged a combined 93.2 points per game this season. Florida State had outscored opponents, 369-72, in the first half of its games — at least until Monday night.
Those who wondered how the Seminoles would respond when seriously challenged would get their wish. Auburn downed a punt at the 2-yard-line, started its next possession 25 yards from the end zone and scored when Marshall lobbed a short pass to Mason in the left flat and watched as he slid up field, 12 yards into the end zone.
The last time Florida State had trailed was on Sept. 28 at Boston College. In the second quarter, no less.
Auburn and its pass defense ranked near the bottom in major college football. But Winston was in the Tigers' cross hairs, the front four applying the necessary pressure, allowing extra men in coverage.
After Marshall dropped a deep ball into the hands of Melvin Ray for a 50-yard touchdown, and after Marshall scrambled left into the end zone on a later drive, Auburn led, 21-3. Marshall had accounted for part of all three scores, Slick Nick with the early lead over Famous Jameis.
Winston, meanwhile, looked confused, vulnerable, unable to summon the magic of his redshirt freshman season, one that culminated with a Heisman Trophy despite an allegation of sexual assault. The accusation hung over the latter part of Winston's season, and yet his play remained consistent — at least until Monday night.
On the day Winston turned 20, he looked more like a teenager than ever before. He finished the first half 6 of 15 for 62 yards, with a fumble lost and two sacks.
That simply set the stage for the final moments, for the kick return and the touchdown surrendered and Florida State's final drive. The game ended, and so did the careers of so many seniors, and so did the tenure of the B.C.S. as college football's postseason system. But for Winston, it was more of a beginning.
Next up: his sophomore season.


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Michel Guérard
Michel Guérard (born 27 March 1933) is a French chef, author, one of the founders of nouvelle cuisine, and the inventor of cuisine minceur.
Guérard served his apprenticeship at the patisserie of Kleber Alix, in Mantes-La-Jolie. He worked at a number of Parisian restaurants, including Maxim's, and in 1958 won the Meilleur Ouvrier de France Patisserie, while working as a pastry chef at the Hôtel de Crillon. He also worked at Le Lido.
In 1965 Guérard opened a restaurant in Paris called Le Pot-au-Feu, which in 1967 earned Guérard his first star in the Michelin Guide. The restaurant gained a second star in 1971, and was successful until it was compulsorily acquired for the purposes of a road-widening.
In 1972 Guérard met Christine Barthelemy, the daughter of the founder of the Biotherm range and the owner of a chain of spas and hotels. They married, and in 1974 he moved with her to Eugénie-les-Bains, where she was running one of her family's smaller, less successful spas. They restored the buildings, and Guérard invented a style of food, cuisine minceur, a form of healthy cooking, designed to lure health-conscious Parisians to travel the 800 km to Eugénie. In 1977 his main restaurant received three Michelin stars, and all his properties in Eugénie have been very successful, transforming the tiny village into a significant tourist destination.
In 1983 Christine and Michel purchased the Château de Bachen, replanting the vineyards, and producing their first harvest in 1988.
Christine and Michel Guérard currently own three restaurants in Eugénie-les-Bains:
- Les Prés d'Eugénie. Part of the main spa hotel, this restaurant serves cuisine gourmande, and has since 1977 received three stars in the Michelin Guide.
- La grande cuisine minceur, with Alain Coumont, Éditions Robert Laffont, Paris, 1976.
- La cuisine gourmande, Éditions Robert Laffont, Paris, 1978.
- Petit almanach des inventeurs improbables et méconnus, with Jean-Paul Plantive, Ginkgo éditeur, 2003.
- L'almanach des petits mestiers improbables, with Jean-Paul Plantive, Ginkgo éditeur, 2004.
- Petit almanach des plantes improbables et merveilleuses, with Jean-Paul Plantive, Ginkgo éditeur, 2005.
- La Cuisine très facile, Recettes pour débutants ou maladroits, Ginkgo éditeur, 2006.
- Chevalier of the Légion d'honneur
- Chevalier of the Ordre des Arts et des Lettres
- Chevalier of the Ordre national du Mérite
- Chevalier of the Ordre du Mérite agricole
- Cailein Gillespie, European Gastronomy into the 21st Century (Oxford: Butterworth-Heinemann, 2001), pp. 127–30.


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Sun-Dried Tomato and Asparagus Vegan Quiche
A fresh and seasonal Sun-Dried Tomato and Asparagus Vegan Quiche made with sun-dried tomatoes and asparagus for a hearty breakfast, lunch, or dinner.
Hey, friends! It's been awhile.
The last couple of weeks have been tough. Aside from dealing with some very difficult personal matters, the past few weeks have been a scramble to get the airbnb ready – (which it is and booked through the month!) and to get Eden into a preschool for the fall and complete the incredible amounts of preschool paperwork (seriously, this is not like growing up in a small town in the 80s). With these immediate needs requiring my attention, it was time to step away from the blog. Now that I have had some time to re-group, deep clean my kitchen, and dust off my computer I am ready to return.
It's good to be back.
And a few things have changed since I've last stopped by.
- I turned 33. While I could easily be tempted to feel like 33 is just a little older than I'd like to be, my year has started off pretty good with two separate incidences of people, upon finding out I have two kids, exclaiming, "but you don't look a day over 24!". It's the vegan diet, people.
- I got a new tattoo for my birthday – first one in 5 years – of a doug fir on my forearm. I'm a pretty big fan of it.
- But most importantly of all, winter is over and spring is here! Felt like a long time coming, didn't it?
Now that spring is finally here, I'm craving all kinds of new foods that the long winter months often make me forget about.
And of course, at the top of that list of newly craveable foods is asparagus. I'm finding the urge to put asparagus in and on everything. It's hard not to when everywhere I look I see bountiful bundles of beautiful asparagus. And with such a short few weeks that the vegetable is actually in season, it would be a shame not to eat it every single day for the next month.
This Sun-Dried Tomato and Asparagus Vegan Quiche was originally scheduled before Easter because it makes a delicious entree to an Easter Brunch and has long time been a holiday staple, but as I said earlier, life got the best of me and this mostly-done post has just been hanging out in my drafts folder for several weeks (along with an Easter round-up and a recipe for white chocolate).
But there's no actual need for a holiday to whip up this easy vegan quiche.
Creamy, rich, and decadent this egg-like custard baked into a flaky pie crust is really perfect for any occasion. So grab a fork and dig in!
A fresh and seasonal Sun-Dried Tomato and Asparagus Vegan Quiche made with sun-dried tomatoes and asparagus for a hearty breakfast, lunch, or dinner.
Cuisine: American
Keyword: vegan quiche
Servings: 8 servings
Calories: 221 kcal
Author: Sarah McMinn
- 1 1/2 cup all-purpose flour
- 1/2 teaspoon salt
- 1/2 cup non-dairy butter I used Earth Balance buttery sticks
- 2-3 tablespoons ice cold water
- 1 tablespoon coconut or vegetable oil
- 1/4 cup white onion minced
- 1 cup fresh asparagus chopped
- 3 tablespoons dried tomatoes chopped
- 1 14 ounce block of medium/firm tofu, drained
- 3 tablespoons nutritional yeast
- 1 tablespoons non-dairy milk
- 1 tablespoon all purpose flour
- 1 teaspoon dehydrated minced onion
- 2 teaspoons fresh lemon juice
- 1 teaspoon spicy mustard
- 1/2 teaspoon sea salt
- 1/2 teaspoon turmeric optional
- 1/2 teaspoon liquid smoke
- 3 tablespoons fresh basil chopped
- 1/3 cup vegan mozzarella cheese I used Diaya
- salt and pepper
- Spray one 9" pie pan or four 5" mini quiche dishes and set aside. Preheat the oven to 350 degrees F.
- To make the crust combine flour and salt in a bowl. Add non-dairy butter in small chunks and with a pastry cutter or your fingers, cut into the dough until it resembles small pea sized pieces (a few larger ones are okay). Add cold water and turn over onto a floured surface to bring together. It will be pretty dry, but should stick together when pressed between your fingers.
- Press into the prepared pie pan(s) and bake for 10 minutes. Remove from oven and set aside to cool while making the filling.
- To make the quiche filling heat 1 tablespoon of oil over medium heat. Add onions and saute until translucent and fragrant (about three minutes). Add asparagus and tomatoes and saute for another three minutes until asparagus becomes slightly tender. Remove from heat and set aside.
- In a food processor or blender combine tofu, nutritional yeast, non-dairy milk, flour, onions, turmeric, liquid smoke, lemon juice, and sea salt until smooth. Transfer to a bowl. Add asparagus mixture, fresh basil, and vegan cheese and stir everything together. Season with salt and pepper to taste.
- Spoon filling into chilled pie crust, smoothing over the top. Bake for 30-45 minutes (less if you are making small quiche) until top has browned slightly and a knife inserted in the middle comes out clean.
- Remove from heat and allow to cool for 20 minutes before slicing. Serve warm.
This post contains affiliate links.


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