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The FDA recently issued a safety warning about a serious condition associated with the use of the antipsychotic drug ziprasidone. Also marketed under the brand name Geodon, this drug is used to treat schizophrenia and bipolar disorder. The FDA warning cautions that taking ziprasidone could cause "a rare but serious skin reaction" known as DRESS. The condition could "start as a rash that can spread to all parts of the body." It can lead to "fever, swollen lymph nodes, and inflammation of organs such as the liver, kidney, lungs, heart, or pancreas", as well as elevated white blood cells. Furthermore, DRESS can be fatal.
The FDA has required an update to the drug labels for all formulations of Geodon that adds a warning about DRESS. The FDA has also urged health care professionals to "immediately stop treatment with ziprasidone if DRESS is suspected."


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When No One's Watching
Listen to Audio (right click to save)
When you play high school football, you learn to play another game too. It's called Impress the Coaches. Of course, the coaches decide who plays, who starts, who sits. All summer long players show up for weight lifting in this steamy, hot weight room. Now, they come three times a week. Why would guys want to come and sweat and strain? Because the coaches are there. You can't help but ask how many of those fellows would show up if, well let's say the coaches suddenly announced they were taking a week off, "Fellows, you keep coming. We just won't be here all next week, okay?" I have a feeling the attendance would really go down in the weight room.
One day back when my boys played football, there was a lot of football equipment that had to be moved to the school. Again, it was a hot, humid summer day. The coach needed volunteers. It's amazing! A lot of guys showed up to carry equipment! Of course, the coaches were going to be there and would notice who helped. Right? If the coaches weren't there to watch, how many guys would have been hauling equipment? I don't know. How many guys would lift on those hot days? How many players would run an extra lap? See, the real athlete works out whether anyone is watching or not.
Does your family see the same Christian that the church does? Do your coworkers, your clients, your customers, your fellow students, your teammates? Take a good, honest look at the private you. Are you faithful to Jesus when there is no one there to impress? That's the real you!
The way you live when there's no one watching is the way you can tell how much you really love your Jesus.
© (c) Ronald P. Hutchcraft
Distributed by Ron Hutchcraft Ministries, Inc.
Learn how to begin a personal, love-relationship with the God who made you.

subset: commoncrawl


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You Can Do: Bumped Up Ponytail
Mark Sullivan/WireImage; Courtesy Photo (2)
A bumped up pony is an easy way to add a little bombshell to an evening look. Still, some wonder how to keep the look sophisticated. Click through the gallery for our step-by-step guide to mastering the style!
MORE:• 100+ Hairstyle Ideas!• Our Favorite Bridal Hairstyles• New Hairstyles 2012


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3 Unusual Ways to Move Toward Emotional & Mental Health
I sometimes totter on the edge of despondency. Especially in winter.
If you are like me, you get stuck in your head and need help moving toward emotional and mental health.
Do you have a secret sadness? Maybe a shapeless grief you can't explain?
What if some unique and creative activities could alleviate melancholy for people like us?
I have found 3 unusual ways to keep despondency at bay. I'm not suggesting changing anything your doctor has prescribed — just bringing a little color to the palette.
These 3 exercises are not easy — but they are good!
When I was in my twenties, I had an eating disorder called bulimia. Looking back, I wonder at how much of my story I kept stuffed inside, rarely sharing the hidden parts of myself. Fresh out of childhood, my feelings were trying to surface but I didn't have an escape hatch for them. This disorder kept me from dealing with the story of my past.
Then I met Scott, who later became my husband. He helped me take an honest look at my life and begin to tell my story. When I told him about my bingeing and purging, it was like a tiny shaft of light broke into my cellar. My heart felt less heavy and I began to let the truth about my childhood come out.
There are many ways to tell your story:
- Talk to a friend, spiritual advisor, or counselor to pop the lid on bottled up emotions. Our negative emotions have a way of dissipating when they decompress and spread their weight across other shoulders.
- Journal. Pen on paper helps disentangle the jumble of thoughts and feelings in our minds and bodies.
- Pray. Our creator knows our weaknesses and fears. He listens well and won't be surprised by anything we have to say.
- Form a fictional tale from your experiences or current turmoil. You don't have to be writer to create a character that acts as a mirror. Can you create a short story to represent what's stirring deep in your soul?
I am the kind of person who spins and spins inside my head until I make myself dizzy and sick. Songwriting has helped me work out a lot of sadness, confusion, and anger in my life. In the process, I found a lot of hope and healing.
Years ago, I wrote a song called "Tell Your Story." As a recording artist, I had the luxury of writing and recording my kind of crazy. Call it music therapy.
Writing a song can be tricky but it's not as hard as you think. You've listened to countless songs in your life and even followed the lyrics on a page as you listened to a favorite artist. What if you grabbed one of those song lyrics you love and used it as a model, a template for writing your own lyric?
- Try to write and sing your lyrics to the same rhythm and melody as the song you are using as a framework. You're not trying to plagiarize and publish here.
- Connect to the emotion of the song you love and write your own words and music.
- Build on snippets from your journal or a poem that connects to your soul.
- Create a tiny soundtrack with your own melody. Go with the flow of emotion that comes from listening to a favorite song.
See if songwriting is therapy for your soul. If you want to go deeper, here are 10 more unusual tips for songwriting.
As a teenager, I belted out a lot of Linda Ronstadt ballads. Singing along with her soulful voice, I found a connection to my own soul. These days, I don't sing a lot around the house or even in the car. I stay too much in my head and must remind myself to sing.
- So sing in your shower, house, or car!
- Join a band or choral group which can be especially healthful and uplifting.
Time Magazine explained the reasons why singing can lift the spirits:
"The elation may come from endorphins, a hormone released by singing, which is associated with feelings of pleasure. Or it might be from oxytocin, another hormone released during singing, which has been found to alleviate anxiety and stress. Oxytocin also enhances feelings of trust and bonding, which may explain why still more studies have found that singing lessens feelings of depression and loneliness."*
Can you bring your hidden insides out to help lift the weight of those heavy emotions?
When I find myself wearing winter blues or spinning inside my head too much, I get to work on one of these 3 ideas. Let me know how it goes for you!
If you want to hear the song I wrote and recorded with my husband as Out of the Grey, check it out here: "Tell Your Story." (lyrics here)
If you want to learn more about songwriting and singing, my handbook/workbook, The Singer and The Songwriter can help.
Clap, Follow me, and Share if this gives you a lift!


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This is the expert-level business continuity management certification. CBCAs with at least 5 years of qualified experience are eligible for this credential. This certification maps to all ISO 22301 Certification competence requirements.
CBCM™ Certification Narrated Tutorial
Building upon the foundation understanding of the ISO 22301 Business Continuity Management System (BCMS) platform validated by the Certified Business Continuity Strategist credential, the Certified Business Continuity Manager (CBCM) certification by CIS attests to your ability and experience to develop the necessary incident management plans (IMPs) and response procedures necessary to fulfill the strategic objectives that have already been finalized. The CBCM also certifies that you have the necessary knowledge, skills, and experience to properly administrate the deployment, testing, and maintenance of IMPs and response procedures.
Getting Certified as a CBCM™
The CBCM™ certification is available to qualified candidates who:
- Are a member of CIS in good standing.
If you are not already an Associate member of the CIS certification student body, you must first become a memberto pursue the CBCM credential.
- Attend all of the following required CIS approved curriculum courses:
If you attend all of the following instructor-led seminars, you will fulfill the training requirement for CICRA and CBCS certification. Seminars may be attended at live instructor-led sessions, online, or a combination of both.
- CIS Policy Workshop: ISO 31000 Enterprise Risk Management
- CIS Policy Workshop: ISO 22301 Business Continuity Management
- Best Practices to Develop, Exercise, and Certify Business Continuity and Disaster Recovery Processes
- Pass the CBCA Exams.
For CBCM certification by CIS, candidates must pass CIS exams RM101, BCMS101, and BCMS 102. CIS exams are administered on-line and can be taken at your convenience at your home or work through the CIS eLearning Center, where your progress and score are monitored and recorded centrally. Your exam results are provided automatically upon completion of your exam.
- Submit your professional endorsements and proof of required experience.
CBCM certification requires at least five (5) years of experience in two or more of the domains of the CIS BCMS Common Body of Knowledge as tested in CIS exams RM101, BCMS101, and BCMS102. Submit three CIS Candidate Endorsement Forms and proof of experience requirements to the Certification Department at CIS Headquarters. Your completed forms and documentation can be mailed, transmitted by facsimile, or e-mailed to:
Certified Information Security
ATTN: Certification Department
1004 Green Pine Circle
Orange Park, FL 32065 USA
Fax: +1(786) 522-9063
E-mail: email@example.com
- Gain final approval from the certification committee and become certified by CIS. You will officially become certified once your exam and credentials are approved by the certification committee. Your certification will be mailed to the address you provided for your membership account. Those who have attained a CIS credential will be invoiced for certification renewal upon annual membership renewal.


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The New York Times released a damning report Thursday detailing multiple allegations of sexual misconduct against comedian Louis C.K., who had disputed rumors of such troubling behavior for years, most recently in September.
The report included accounts from five different women who described various incidents of alleged sexual harassment by the comedian, born Louis Székely. Posted By Ghost


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Your Personal Date Night ConciergeJoin Free for a Month
Bloveit is a date night concierge service that helps busy couples plan awesome dates
at the click of a button.
Tell us what you like and we'll plan everything out for you.
It's date night like you've never experienced it before.
Personalized. Effortless. Magical.
All of the fun. All of the brownie points. None of the work.
Bloveit is currently only available in Atlanta.
Not in Atlanta? Sign up to stay up to date on our new city launches.
Bloveit is the fastest, easiest, most effortless and delightful way keep your most important relationship healthy, adventurous, fun and exciting!
10 minutes into our first Bloveit experience, we were ready to sign up for a whole year"
Doing the same things and going to the same places might feel safe and familiar, but it can also get stale and boring after a while.
That's why at Bloveit we scour your city to offer you the best new restaurants & experiences to keep your date nights fresh, fun and exciting.
My boyfriend and I love to try new restaurants, so when the guys from Bloveit said they could pick them out for us, curate a menu of great food options, and we could order/pay ahead of time, we couldn't say yes fast enough"
We know how long it can take to plan a great date night. Now imagine spending that time planning date nights on some sort of regular basis.
Not only is it lightning fast to set up a Bloveit date, it's also fun and stress-free. Imagine that!
We had a wonderful experience! Bloveit made our anniversary dinner so easy. All the thought process of what we want to eat was dealt with before we arrived, our drinks were picked by Bloveit. All we had to do was show up and enjoy each other"
"So what do you want to do tonight?", "I don't know. What do you want to do?" Sound familiar?
Picking a place for your date night can be tough. That's why we use your specific tastes and preferences (cuisine, budget, travel time, etc) to make personalized recommendations of restaurants, menu items and ideas that you and yours are sure to love.
It was so cool that Bloveit took the time to get to know us and what we liked in a date, food, and drinks to really create an amazing experience for us. I really wish our next Bloveit date was sooner!"
Have you ever ordered what you were going to have at a restaurant before you got there? It's pretty awesome.
But what's even more awesome is how our unique menu pre-selection process leads to the most seamless, smooth and delightful VIP type dining experiences ever! No menu. No bill. When you're done, just get up and leave.
It was definitely really cool. I felt like we were super important, and that our date was even cooler than normal. We were able to enjoy each other's company without any distractions, and the staff made us feel like movie stars"
Have you ever been at dinner at wondered where else your night could go? What could you do next?
We believe that the best dates are more than just dinner. The best dates have multiple stops. Dinner, then a show, then drinks on a rooftop bar. Yeah... that's more like it! And that's where we want to take you.
Our date night lasted 2 full hours, instead of the typical 40min date night dash haha"
Whether that's making reservations, making sure the restaurant knows about your allergies, figuring out travel plans, where to park or what to wear. That's what we're here for.
Instead of researching all those details yourself, Bloveit proactively plans out your entire night for you, so you can focus on what matters most.
With Bloveit, date nights go very smoothly! We just show up and enjoy the experience rather than having to make decisions and hope a reservation is available when we decide to go out at the last minute"
Why? Because we know that life can get busy and sometimes you forget to plan for date night. That's why Bloveit automatically reminds you and helps you schedule a date night at least once a month.
So keep your busy career, take care of your friends & family, and spice up your love life, all at the same time.
What a pleasant surprise! We all get busy and the last thing I want to do the last second is to have a date that's not well planned out, so the whole experience with Bloveit was perfect. It took out the work, but kept the surprises intact"
The date night you've always dreamed of
is finally here.
Personalized. Effortless. Magical.
The Bloveit team went the extra mile to make it special for us and needless to say we will be celebrating a lot more than just anniversaries now that we have the Bloveit guys on our side!"
NO COMMITMENT. CANCEL ANYTIME.Join Free for a Month


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Business Consulting Council (now part of CWC Consulting) offers Small and Medium Enterprises (SMEs) a multitude of business development services. In todays ever-changing business arena a business must be in tune with the latest technologies and resources that are available. The purpose of this website is to help, educate and serve as a resource for todays SMEs.
Individuals have doctors, automobiles have mechanics and todays small to medium sized enterprises have Business Consulting Council. At BCC we have a plethora of diverse resourceful professionals from all corners of business that have the innate ability to analyze and give plausible solutions to various business challenges - Brand Development, Public Relations, Viral Marketing, Strategic Planning, Market Analysis, Holistic Business Consulting and Management Development are just a few of the areas that BCC can assist your organization.
Business Consulting Council represents a partnership, a win-win, a success that earns the full confidence of all engaged in the awesome process.
We encourage you to browse through this site and bookmark it as we are constantly updating it with pertinent data that will be helpful in gauging whether your business is on the right track to success!
Search Optimization Company was formed by the original technologists who coined the term SEO and Clinton Cimring who invented SEO 2.0 and is the co-founder of Baidu.
Social Media Firms is an all-incluvise digital marketing and design service for Facebook, Instagram, and Twitter.
$99 website design is designed to offer a basic website to start-ups and businesses that may not yet appreciate the value of a website.
SEO White Label was also started by the founders of SEO and is designed to be a whoelsale reseller of optimization services to other retail SEO companies.


text: 17 May, 201824 May, 20180 Summer Campusin Kitesurf, Paddle Surf For a different summer, sea and lots of fun for kids!!!!!!!!! Comparte esto:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Click to share on Google+ (Opens in new window)Like this:Like Loading... Relacionado Leave a Reply Cancel Reply Your email address will not be published. Comment Your name * Your email * Notify me of follow-up comments by email. Notify me of new posts by email.


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Carson Meyer - Carson Meyer seen attending Joel Silver's Memorial Day party - Los Angeles, California, United States - Tuesday 31st May 2016
Joel Silver - UK premiere of 'The Nice Guys' held at Odeon Leicester Square - Arrivals at Odeon Leicester Square - London, United Kingdom - Thursday 19th May 2016
Joel Silver, Ryan Gosling, Russell Crowe , Shane Black - 'The Nice Guys' U.K. Premiere - Arrivals at Odeon, Leicester Square - London, United Kingdom - Thursday 19th May 2016
With a premise not much more believable than Snakes on a Plane, this slickly made thriller entertains us from start to finish by never flinching once. It may be utterly ridiculous, but it's played with full-on dedication by a gifted cast and a filmmaker who knows how to ramp up tension out of thin air, so to speak. Yes, it's utterly idiotic, but it's so much fun that we want a sequel even before this film crashes to the ground.
Relapsed alcoholic Air Marshal Bill (Neeson) has far too much personal baggage as he heads to work on a trans-Atlantic flight. Still grieving over his daughter's death as he drinks a bit of coffee with his whiskey, his hopes of a quiet flight are soon dashed when he receives an in-flight text threatening to kill a passenger every 20 minutes if he doesn't pay a huge ransom. So he kicks into action-man gear. But things start getting seriously surreal as he struggles to find anyone on the plane who doesn't look shifty. He seeks assistance from steely stewardess Nancy (Dockery) and too-helpful passenger Jen (Moore). But everyone begins to wonder if Bill might be the real villain here.
Filmmaker Collet-Serra packs the screen with red herrings, as all of the passengers fire wary glances at each other, moan about the general chaos of the flight and do all of those stupid things that make air travel so tiresome. The only thing missing is a screaming baby. Not that you'd hear it above the crazed panic this cat-and-mouse situation induces. It's so frantic that we barely have time to wonder how someone could get on a plane with a briefcase full of cocaine. Or a bomb. So we just hang on as the turbulence escalates.
Continue reading: Non-stop Review
Set in 1947, 'Who Framed Roger Rabbit?' is the story of how cartoon characters known as 'toons' can interact with the living human society. However, after compromising pictures of the human owner of Toontown and Hollywood toon star Roger Rabbit's wife Jessica emerge, he is set up for his subsequent grisly murder and things get tense between the toon world and the real world. Toon hating detective Eddie Valiant is hired to investigate but winds up helping Roger after discovering that he is being framed for a crime he didn't commit. His investigations lead him to the mysterious Judge Doom who's own nature in the toon community is formidable with having found a way to destroy them.
Continue: Who Framed Roger Rabbit? - Clips
Ritchie, Downey and Law are back with another manic romp that feels more like a Victorian James Bond adventure than anything about the famed Conan Doyle characters. While it has the same comical energy, it's not quite as fun as the first go-round.
Brilliant Cambridge professor Moriarty (Harris) is up to no good, taking on Holmes (Downey) by messing with those around him, including his girlfriend-nemesis Irene (McAdams) and his partner Watson (Law), who plans to retire after his upcoming wedding to Mary (Reilly). But nothing goes as planned, and Holmes and Watson are propelled into a vicious game of intrigue that sends them to Paris where they team up with a sexy gypsy (Rapace). They also get help from Holmes' brother Mycroft (Fry) as they head to a climactic showdown in Switzerland.
Who needs logic when the action is this wildly exhilarating? And much of it is drastically slowed-down so Ritchie can show us Holmes' powers of deduction as well as whizzing bullets, explosions and other cool-looking things. The dialog is the same mix of faux intelligent banter and shameless innuendo, which gives the actors something to play with, especially as Downey and Law amusingly move beyond bromance into Brokeback territory.
But we do need some logic. This plot is so messy that it never engages us. And as it builds to a climax in a crazy cliff-perched Alpine castle, we begin to lose interest. Even with the bigger action, zingy dialog and colourful characters, this film barely works up any steam. Whenever Holmes isn't being mischievous, Downey actually looks bored. And Rapace is so sidelined that it's difficult to understand why she's here at all; the filmmakers never give her anything interesting to do.
It's a shame the screenwriters never push the characters further. But at least Ritchie keeps things moving briskly, filling the screen with comical nuttiness and big-gun mayhem. Even if Moriarty makes no sense (would someone this intelligent resort to such a ridiculous plan to make his fortune?), Harris adds heft in the role, including some jagged chemistry with Downey. Let's just hope that the requisite third film lets us in on the joke.
Joel Silver - Joel Silver and Karyn Fields Los Angeles, California - LACMA's Art And Film Gala Honoring Clint Eastwood And John Baldessari at LACMA Sunday 27th November 2005
On a mission in Bolivia, a five-man black-ops team is betrayed by their power-mad CIA boss Max (Patric) and left for dead. But they embark on a mission to get revenge and clear their names, with Clay (Morgan) leading techie Jensen (Evans), demolition expert Roque (Elba), driver-pilot Pooch (Short) and sniper Cougar (Jaenada). They also enlist the help of a sexy-but-shady woman (Saldana) as they track Max and his vile henchman (McCallany) from Miami to Los Angeles and try to stop his nefarious Bond-like plan.
Continue reading: The Losers Review
Joel Silver Wednesday 9th September 2009 The LA premiere of Whiteout at the Mann's Village Theater in Westwood, California
RocknRolla is sexy, fast, loose, smart, and extremely funny. It's crammed with colorful criminals, which Ritchie and cinematographer David Higgs backlight to great effect. It chokes on delightfully screwy schemes, which the director and his editor James Herbert slice, tape, and test drive at breakneck speeds. And that's the key. It keeps moving, hardly caring if you are keeping up.
Continue reading: RocknRolla Review
What they generally aren't is full of capers designed by crackheads in search of comic relief, or a dominatrix dying to destroy the gold market with a Da Vinci alchemy machine only a cat burglar from Hoboken could steal.
Continue reading: Hudson Hawk Review
There you have Osmosis Jones, a combination of clunky live action and cool, creative animation that tries too hard to please both adults and kiddies while journeying inside one disgusting body.
Continue reading: Osmosis Jones Review
I remember a time when I used to enjoy Seagal. Such films as Above the Law, Hard to Kill, Marked for Death, Under Siege, and Out for Justice are all solid action films from the '90s. Under Siege is even kind of good. But lately, films like Under Siege 2, Fire Down Below, and The Patriot have shown the age of the Italian stallion of Aikido.
Continue reading: Exit Wounds Review
Unfortunately, star Bruce Willis, director John McTiernan and company couldn't duplicate the heart-pulling thrill of the first one with two increasingly mediocre sequels. Die Hard 2 and Die Hard: With a Vengeance suffered because of stuffing thrills and spills in every crevice, to the point where I expected the Road Runner to make a cameo. Everyone involved seemed to forget that simplicity made the original so riveting. There's one flawed New York City detective trapped in a skyscraper with only his wits and some firearms to stop a band of talented international terrorists.
Continue reading: Die Hard Review
But can you technically call this new House a remake? Helmed with vague sensibilities by music video director Jaume Serra, this vacant lot bears absolutely no resemblance to its predecessor, save for the fact that they both feature suspicious wax museums. That's like saying Titanic is a remake of The Poseidon Adventure because they both take place on capsized luxury liners.
Continue reading: House Of Wax (2005) Review
Writer-director Shane Black returns to the comedy-noir vibe of his 2005 hit Kiss Kiss Bang...
With a premise not much more believable than Snakes on a Plane, this slickly made...
Set in 1947, 'Who Framed Roger Rabbit?' is the story of how cartoon characters known...
Ritchie, Downey and Law are back with another manic romp that feels more like a...
With a Hitchcockian mistaken-identity plot, this film can't help but draw us into its slickly...
Raucous and colourful, this comical action flick should be great fun, but a lack of...
Although it feels like a parallel story taking place at the same time as The...
For a laughably preposterous thriller, this film is slickly made and much longer than expected....
Here's some good news for Guy Ritchie fans. RocknRolla gives off the impression that the...
Violence is inherent. Brought on by fear, anger, despair or ignorance, it's a side of...


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March 15, 2012 2:39 PM
What's slowing vSphere 5 upgrades?
Profile: Nick Martin
As is typical with many software updates that follow a stable product, there are still a lot of VMware customers delaying the upgrade to vSphere 5. In many cases, it's just a matter of customers waiting to see how the new product shapes up. Better to let others run the gauntlet and then stroll in...
March 14, 2012 3:06 PM
Like many IT pros, Charles Barkley doesn't understand the cloud
Profile: KeithKessinger
This cloud computing commercial with Charles Barkley is very revealing on so many levels.
- We learn that the 1993 NBA Most Valuable Player and 1992 Olympic gold medalist doesn't understand the value of moving mission-critical workloads to the cloud. (In his defense, many CIOs and IT...


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Finding the right shoes can be confusing, especially with the wide selection of models and styles available. What should you be looking for when getting shoes? Do you know what the latest styles are? A lot of shoe questions must get answers before you go to a shoe store. If you want to learn about shoes, keep reading!
Try not to wear athletic shoes when you aren't wearing socks. You can hurt your feet from the shoe rubbing against the skin if you do this. In addition, you could experience foot fungus. Use foot powder and cotton socks to keep your feet dry.
Measure both of your feet when you shop for shoes. A lot of individuals have a foot that is slightly longer or larger than the other. For the most comfortable fitting shoes, buy a size that fits the larger or longer foot.
Determine the type of arch you have before choosing your athletic shoes as not all are made to fit every type of arch. Wet the bottoms of your feet and step on white paper. The wet footprint will show you the kind of arch your foot has. If it's flat, you will see most of your footprint. If you have high arches, the middle portion will not show up. This is a good way to find the right fit.
When online shopping for shoes, figure out what the return policy is. You'll find that from time to time you will get something that you can't try on from the Internet, and you'll want to return the item. See if they have a money-back guarantee so that you aren't stuck with shoes you cannot wear.
Don't think that your shoes are going to get broken in if they are very uncomfortable while trying them on. You shoes should be comfortable when you initially try them on. The shoes may not stretch out in the manner that you had anticipated. They may just end up damaging your feet instead.
If you want to get your kid to get ready for school faster, it may be a good idea to use some Velcro strapped shoes. Tying shoes takes ages. Buy a pair of shoes with Velcro and a pair of shoes with shoelaces.
Try putting together a large collection of shoes so you can easily find something to wear for every occasion. Shoes can make or break an outfit, so it is important to pay attention to your choices. You cannot go wrong if you match your shoes with the clothes you wear.
When buying shoes for your toddler, ensure they offer stability. When toddlers start walking, sturdy shoes can help. Tennis shoes are best for children who are just learning to walk. Anything with a slick sole should not be purchased.
As previously stated, you can never know too much about shoes. There are many choices when it comes to purchasing shoes. This article offers many tips about shopping for shoes. Use these tips the next time you go out and make a shoe purchase.


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Data Breach Bootcamp
IAPP Europe Data Protection Intensive 2018
April 17, 2018
Sylvie Rousseau
Liisa Thomas
With GDPR, the reality of data breach notification and response is truly hitting home for EU companies. This unique, interactive simulation will help you prepare your company for a data breach. We will cover the various stages of a breach, from investigation, notification, post-incident follow-up, and more. We will address how to handle tricky legal notification issues as well as how to balance risk when public relations reasons require disclosure before full facts are identified.
For more information and registration, click here.


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Alternative for Germany (AFD) co-founder Alexander Gauland says his compatriots should be proud of what their soldiers achieved during both World Wars, and the country should stop apologizing for its Nazi past.
The 76-year-old politician made the remarks during a speech to party members in Thuringia on September 2.
"If the French are rightly proud of their emperor and the Britons of Nelson and Churchill, we have the right to be proud of the achievements of the German soldiers in two world wars," said Gauland.
The AfD is no stranger to controversy. In January senior party leader Bjoern Hoecke criticized the well-known Holocaust Memorial in Berlin, branding it a "monument of the shame in the heart of the capital."
The AfD won 13% of the vote and came a stunning third place behind the main center-right and center-left parties in the recent election.
It polled particularly strongly in the former East Germany, which includes Berlin, attracting 21.5% of the vote, according to exit polling conducted by Infratest Dimap. In the West, it scored about 11%, the projections said. The results put the AfD on course to become the second largest party in the east, after the CDU.
Talks about the seating plan for the new German parliament have ended in deadlock with only one matter agreed. All parties want the Alternative for Deutschland (AfD) should sit on the far right of the chamber, which ironically, that sparked concerns about their proximity to the government benches.
"We could live with that. That is similar to the regional parliaments. We will be sitting next to the government bench, that's very nice," Bernd Baumann, from the AfD's parliamentary executive board, said.
The AfD passed the five percent threshold for the first time to secure themselves almost 100 seats in the Bundestag in Berlin.


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Israel offers film and video producers historical, religious, archaeological and natural locations – all within a relatively short travel time. From the religious locations of Jerusalem, the Church of the Holy Sepulcher and other sacred Christian monuments; Haram-Al-Sharif (Temple mount) with Al Aqsa Mosque on its top; and the Jewish Western Wall. In addition to the main film locations in Israel, there are hundreds of other religious locations throughout the country.
Variety of film locations in Israel
When you're looking for filming locations, we offer the experience of years of location scouts in Israel: Specific desert spots in the Negev or Judea Desert; long sandy dunes along the Mediterranean beaches; the rugged coast of the Dead Sea or fascinating underwater riffs near the city of Eilat; nonstop night life in Tel Aviv, and rustic landscapes in the Galilee. Most sites are available for filming almost year long, including seaside locations: Mediterranean coasts, as well as the Sea of Galilee, Dead Sea and the Eilat bay.
Location experts
Our experienced fixers and location managers have been researching, coordinating, clearing and managing locations in Israel since 1998. Whether it is a documentary, a TV commercial spot or a feature film, Israel is one great location. Our location managers will prepare the scout with your scout or recce team. He or she will do the preliminary work by themselves and share footage and photos of the suggested locations. Our work volume allows us to provide a fast track of film permits.
With the recent political turmoil in the Middle East, Israel has become one of the best countries to film in a large variety of locations: Biblical-historical, contemporary (Iraq, desert, Afghanistan lookalike locations), big city scenery in Tel Aviv, and the mountainous landscape of the Galilee.
Several location photo collections are available online, while others, including drill-down to specifics, are available upon request.
So feel free to contact us with your wish list of locations, and we will do everything to make it happen!


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Do you want to improve your smile, but are worried about the time and price of traditional braces? Then Six Month Smiles could be the perfect fit for you! Six Month Smiles gently straightens your teeth with clear braces and tooth colored wires in a reasonable amount of time - usually about Six Months. To learn more about how Six Month Smiles may help you click on the videos below:
The first step towards a beautiful, healthy smile is to schedule an appointment. Please contact our office by phone or complete the appointment request form below. Our scheduling coordinator will contact you to set up your appointment. Please do not use this form to cancel or change an existing appointment.
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Dr Reynolds dental facility is the ultimate wonderful dental experience. Great parking available right in front of the office so you can walk right in. The decor is beautiful and they have great magazines and coffee. I almost never have to wait over 5 minutes. The staff is friendly and welcoming. The chairs are comfortable and they have tv's in every exam room. They also have windows in the exam rooms so it isn't claustrophobic. They have state of the art equipment. The staff explains what they are doing and using so that you aren't caught off guard by anything. They offer cosmetics without being pushy. I would recommend his practice to anyone and everyone in the city of Birmingham. The location is convenient as it is very close to IH 65 near the Alford Avenue exit.
BH - Birmingham
What a wonderful staff and an incredibly knowledgeable dentist. He end years of jaw pain by fixing my bite! Can't say enough good things about this group.
KH - Birmingham
I am a new patient to Dr. Reynolds. My appointment was received without hassle or wait. The environment is extremely professional and far exceeded my expectations. The staff is warm and welcoming. The office is aesthetically appealing. I went in due to discomfort of a tooth and received a root canal without any pain or discomfort at all. The dental service was like sitting at home in the living room in your favorite comfy chair, reclining of course. With t.v. remote in hand and in my own private suite, my root canal was comfortably done in record time! X-rays were done with out having to change locations in the office. Yes, Dr. Reynolds office and staff is modern and technologically precise! I even got emails and text messages to remind me of my appointment. To top it all off, the morning after my root canal I received a personal call from Dr. Reynolds to check on how my mouth was feeling, WOW!!! #CUSTOMER SERVICE#WARMTH#BEAUTIFULRESULTS!!! You will FORGET you are at the dentist!


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About Upscale Resale Furnishings
Upscale Resale Furnishings is filled with new and used furniture for your home or office at a fraction of the original cost. Inventory changes daily. Browse our web site to view a portion of our high quality and very desirable pieces.
We offer furniture for every room in your house
At Upscale Resale you will find stylish furniture and accessories at reasonable prices. We invite you to view our high quality, desirable pieces: A cornucopia of traditional, contemporary, European, and classical living room, bedroom, kitchen and dining room furniture and accessories. Browse our website to see a sample of our store items or preview items that are "coming soon" to our store.
Items in our store come from a variety of resources: lavish private homes, model homes, store liquidations and brand new unique pieces purchased from Highpoint, North Carolina's International Furniture Show. Come discover our hidden treasures! You'll never know what you're missing until you visit our store. Those with impeccable taste will find great values and gorgeous furniture. All items are previewed and individually chosen for our store. Many people visit our store frequently and view our website often. If there is something you are looking for that does not appear on our web site please give us a call.
Join Our Email List or 'Like' Us on Facebook
At Upscale Resale Furnishings we notify our most loyal clients about upcoming promotional events; Store Sales, Model Home Arrivals, Liquidations and our many fun events throughout the year.
Click here to be added to our email list and receive FREE special updates about special events and sales.
Buyers Promise
We take great care (personal visits) to inspect, clean and repair our merchandise prior to accepting it for our showroom. We make every effort to accept only the best quality pieces and to inform you about each piece.
"The Game"
Many clients like to gamble and play the "mark-down" game. Every 30 days if an item does not sell, it automatically is reduced. Throughout the years many shoppers have learned, if you love it-don't play the game! You just might lose it to another smart shopper.
Before You Commit, Be Sure it Fits!
All sales are final. We will gladly lend you a tape measure! Also, remember to measure your doorways and space at home too.


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75 day Broccoli. Compact plants have good holding ability with heat tolerance. Uniform medium green domed heads.
50 seeds per packet.
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Kids can latch on to words in the most incredible ways. And second language learners really keep a teacher thinking. As an English speaker, I give almost no thought to words and phrases we use every day that have multiple – and often unrelated connections – to meaning. As a teacher of ELLs, however, that becomes part of the plan for each lesson. And as a teacher of a classroom made up of nearly three-quarters English Language Learners, it is a way of life.
This week, as we explored inferring unfamiliar words, that last point was brought to the fore with the following exchange:
Did China people eat off special plates on the Titanic?
This question did make me stop and wonder for several seconds – what in the world was this kid referring to? We had just finished looking for text clue to help infer the meaning of demitasse found in an article we were exploring from Harvey and Goudvis' Comprehension Toolkit Source Book entitled "Titanic's Legacy". Where was this question coming from?
As it turns out, the question was not so out-of-left-field as I thought at first. One of the other illustrations found on the page we were studying was of a "China Serving Plate". Which led us to a whole tangential discussion of the word "china".
Never underestimate the power of words. Or the challenge of vocabulary.


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We are experts in interim, final, prohibitory, mandatory and springboard injunctions, and those in support of arbitration proceedings.
We act on behalf of individuals and businesses in relation to all manner of injunctive relief by the English courts, including the following:
- Interim and final injunctions
- Prohibitory and mandatory injunctions
- Quia timet and springboard injunctions
- Injunctions in support of arbitration proceedings.
We are experts in relation to what must be established to obtain an injunction in the context of a domestic dispute under section 37 Senior Courts Act 1981, and, in particular, the application of the American Cyanamid principles.
We can advise as to how to apply for an injunction (including specific requirements when making a 'without notice' application) and how an injunction may be challenged or varied.
Most of all, we can act very quickly and offer a 24/7 service. In the event that you need an urgent injunction, please contact our 24/7 advice line on 07833 241 602.


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Agencies near Warsaw, IN
Warsaw, IN Home Health Care Agencies
Miller's Health Systems DBA Miller's Merry Manor1690 South County Farm Road
Great Lakes Caring334 N Enterprise Dr Medicare Rating:
★★★★★ Care
★★★★★ Satisfaction
Kosciusko Home Care & Hospice1515 PROVIDENT DR STE 250 Medicare Rating:
★★★★★ Care
★★★★★ Satisfaction
Irish Home Care334 Enterprise Drive
HealthForce - WarsawBowen Center, 850 North Harrison Street
Add Your Facility Adding your assisted living to the directory is completely free.
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Cities Near Warsaw, IN
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Warsaw seniors that want to remain independent and live in their homes but need some assistance should consider an in-home care provider. Warsaw, IN home care agencies can provide seniors with assistance with daily activities and minor medical services in the comfort of the resident's home or apartment.
Seniors in Warsaw can stay in their homes and have home care workers visit to help with basic daily tasks and other services such as medication management. There are 5 home care companies that serve the Warsaw market.
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- What is Home Care?
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Communication and autism
Autism is a complex condition where communication may be specifically impaired in terms of understanding language, appropriate use of language and acting on information received. This event will enable participants to gain insight into the complexities of communication for individuals with autism and explore ways to reduce barriers to communication.
For more information, visit http://www.bild.org.uk/our-services/events/the-bild-training-events/understanding-autism-events/communication-and-autism/
- What
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- 17 June 2013 07:30 to 14:30
- Where
- Midlands
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- Events Team
- Contact Email
- email@example.com
- Contact Phone
- 01562 723025
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Adults Blue Oxford Cotton showing shirt
Regular price
Our Oxford cotton showing shirts are made especially for us to give a crisp immaculate look yet still providing freedom of movement, all our sized by collar size
To get the correct size - Measure around your neck just above your collar bone, putting 1 finger between the tape and your neck. Or simply measure and add 1/4 inch. Round up to the closest ½ inch size


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Since the #MeToo movement took off, with thousands of women sharing their stories and dozens of powerful men being outed as abusers and harassers, one thought has dominated my mind: how will this end? In the wake of numerous new allegations against powerful men in culture and politics, I think I have the answer.
All moments of feminist progress are followed by intense backlash, and this swell of accusations - and the seeming tipping point of the culture believing women - will be no different. Too many men are losing their jobs, too many reputations tarnished. A misogynist culture won't allow a reckoning this successful to continue for long.
But #MeToo won't be smacked down all at once, it will be a slow chipping away of our confidence in women's stories and the belief that the behavior of abusers is really that bad.
We caught a glimpse of this on Wednesday, after The New York Times broke their long-awaited expose on comedian Louis CK and The Washington Post ran a story alleging that Roy Moore - the Republican Senate candidate in Alabama - preyed teen girls, one who was 14 years old at the time.
While the vast majority of reactions to these latest accusations was condemnation, we also saw a glimmer of doubt. Mitch McConnell said that Moore should pull from the Senate race "if these allegations are true," but didn't elaborate on why multiple women going on the record wasn't proof enough of the truth.
Other Republican officials defended Moore more explicitly: Alabama Marion County Republican chair David Hall told one reporter: "I don't really see the relevance of it. He was 32. She was supposedly 14. She's not saying that anything happened other than they kissed." (In truth, the woman alleged Moore tried to get her to fondle his genitals.)
Sean Hannity claimed that the alleged encounter was "consensual" (14 year-olds cannot consent to sexual activity with adults). And conservative news site Breitbart insinuated that Moore's predation was acceptable because he was "romantic" and "read poetry" to one child.
The responses to CK have been less explicitly a defense, but more insidious - sly questioning about whether the comedian's alleged behavior (masturbating in front of women without consent) was illegal or really all that terrible.
John Podhoretz, columnist at the New York Post and contributing editor at the Weekly Standard tweeted, "What did [CK] do either as a criminal or actionable matter that merits this expose exactly aside from being unspeakably disgusting?"
I've heard male friends express relief that CK wasn't accused of rape; as if on the spectrum of harassment and assault, what he did wasn't as horrific as other kinds of assault. As one man responded to Buzzfeed's culture reporter Anne Helen-Petersen, "I thought this was going to be career ending. Some women really need to stop wasting people's time."
And on a Reddit forum dedicated to the comedian, one fan wrote, "it's not Cosby or Weinstein or Kevin Spacey behavior...it sounds like was lonely and desperate."
Even CK himself doesn't seem to understand the seriousness of what he allegedly did. According to one of his accusers, CK apologized for asking to masturbate in front of her, saying "I used to misread people back then" - as if the behavior was an ill-fated come-on rather than abuse.
Exposing yourself to women and masturbating without their consent is a form of a sexual harassment and abuse - it's meant to intimidate and to humiliate. Alexandra Katehakis, the clinical director of the Center for Healthy Sex, told The Cut: "A man who does this kind of thing likes to see a woman feel terror and beg him to stop...There's a sadism and a cruelty to it."
I suspect in the days to come, we will hear CK described again and again as pathetic rather than predatory. That we will hear about how things were "different" years ago when Moore allegedly attempted to have sex with minors.
As #MeToo outs more men, we will see a doubling down on misogynist norms and excuses for male violence. I'm fairly certain that's why we're seeing so many women come out with their stories all at once now - many of them know that a few weeks from now, they may not be believed.
We're getting a glimpse of how sexism could undo the progress of the last few months, and how women could suffer because of it. The backlash will snowball just quickly as the accusations against men have. Best we prepare for the storm.


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LED Solar / Wind Navigation
Price: FJD $
Quantity Available: 1
Part #:SA50154
* Designed as a Navigation and Safety combination light.
* 8-33V light functions are hardwired and controlled via the vessels switch board.
›› Navigation (Port, Starboard, Stern)
›› Anchor Light (All Round White)
* Safety/ Warning lights utilise the lithium battery which is charged via Solar, Wind and External power source.
* Solar/ Wind powered functions
›› Day/ Night Red Flash 2s
›› Red Flash 1s
›› Red Steady
›› White SOS
›› White Steady (anchor)
* The first function utilises light-sensitivity activation to automatically turn on/ off.
* The other functions can be activated via the wireless remote.
* Solar/ Wind powered functions will not operate while hardwired functions are in operation.
* An 8 hour initial charge may be required.
* To maintain optimal battery life the unit requires charging every 3 months.
* Can be used on vessels up to 20Mtr
* Designed according to the COLREG72, EN14744 and IEC60945 standards.
* LED Colour: Tricolour (Port/Starboard/Stern) / All Round Red or White (Warning/Anchor Light).
* 1 Year Warranty.
* Powerboats (length up to 20Mtr)
* Sailboats (length up to 50Mtr)
* Fish Boats
Accessories Include:
* 1 x Shim
* 1 x Wireless Remote
* 1 x Instruction
* 1 x Anti Bird Thorn
* 1 x L Shape Support
* 2 x Nuts
* 6 x Screws
* 6 x Clips
Navigation Light Functions:
Tri White (8-33V External / Steady Light)
112.5° Red / 112.5° Green / 135° White
Visability 2NM
Anchor Light (8-33V External / Steady Light)
360° White
Visability 2NM
Warning Light Functions:
Obstacle Light (Light Activated / Flashing 2s)
360° Red
Max. Continuous Working Time: 300hrs
Indicating-Position Light (Wireless Remote / Flashing 1s)
360° Red
Max. Continuous Working Time: 300hrs
Trouble Indicating Light (Wireless Remote / Steady Light)
360° Red
Max. Continuous Working Time: 12hrs
Distress Signal Light (Wireless Remote / SOS Signal)
360° White
Max. Continuous Working Time: 30hrs
Emergency Light Equipment (Wireless Remote / Steady Light)
360° White
Visability 2NM
Max. Continuous Working Time: 12hrs
IP Rating: IP56
Main Dimensions: 115mm x 99.1mm
Rechargeable Battery: Lithium – Solar/Wind External
Remote Control Distance: Max. 30Mtr
Mounting: Vertical or Tube 19-32mm
Frame Colour: Black
Storage Temperature: -30°C~+65°C
Volts: 8-33V
Watts: <45W
LED Chip Size: 27 x SMD 3020, XB-D, CPDP
Note: Exclusive to Sam Allen Wholesale.


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CASE Advocacy and Consultation Clinic provides services including professional advocate consultation to improve outcomes for students in school, IEP/504 Plan Prep and Review Sessions, and Self-Advocacy Coaching Sessions to teach strategies that help parents navigate the special education system with less stress. If you need professional advocacy services, in-depth consultations are available. Services are fee-based. Sliding scale provided on an individual basis. For more information, or to request services, click HERE.
Empowering Parent Partners Program: Parents/caregivers are matched with trained volunteers to provide support, to take notes and to help them navigate their IEP or 504 Plan meeting. If you are interested in receiving this service, click HERE to fill out an application.
Parent Connections Support Groups provide parents with a safe and supportive environment to discuss their concerns with others who "get it." Meetings are held on the second Tuesday and Thursday each month from September to May. New this year! Online support groups are held once a month via an online meeting platform called Zoom. For information about the dates, times, and how to access our meetings, contact us at firstname.lastname@example.com. Attendance is free.
Private Parent Connections Facebook Group serves as a forum for parents to ask questions and receive information and support from CASE members. This group is open to Evanston parents/caregivers of children with special needs. For more information and to fill out a form to receive an invitation, click HERE.
Document Organization Sessions provide you with an easy system to organize the chaos of paperwork. Bring your box, bag or jumbled folders and CASE will help you get organized. Make an appointment by calling or emailing us.
On the CASE newsletter comes out monthly. It includes articles, resources, announcements regarding our advocacy projects, and information about our programs. Visit our "Newsletter" page to sign up for our mailing list and to read back issues.
Evanston CASE Public Facebook Page informs and inspires readers. Please "Like" us to spread the word.


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QUT Big Lift
QUT Big Lift is a student project aimed at giving young volunteers the opportunity to make a difference and pay it forward in rural and indigenous communities whilst engaging in meaningful experiences and producing identifiable outcomes. We facilitate annual road trips to communities in Queensland participating in service projects and community engagement. So jump on the bus and find out how you can give our local communities a big lift!
Email: email@example.com
Website: www.qutbiglift.org
Facebook: www.facebook.com/qutbiglift


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|» Products
|» Chemicals
|» Calcium Carbonate
Our firm commenced its business in 2010 as a manufacturer, exporter and supplier with an aim to offer Calcium Carbonate. This chemical provides natural buffer effect to a pollution filter. The offered chemical is processed by our igneous professionals using pristine quality basic compounds and advanced processing techniques. In addition to this, we are offering this Calcium Carbonate to our clients in various packaging options at market leading rates within the committed time frame.
R. K. UDYOG All Rights Reserved.(Terms of Use)
Developed and Managed by Infocom Network Ltd.


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Table of Contents
At the beginning of the embryonic development, the embryo does not have any specific gender. The development of the male and female embryo is identical in the first seven weeks, although the gender is usually already determined at the chromosomal level since fertilization. Which gender the embryo is going to have and, consequently, which genitals are to develop depends solely on the existence of a Y-chromosome.
Psychological gender identity is to be distinguished from anatomical development. The two generally correspond with each other, however, malformations during genital development can have an impact on them.
Development of the Gonads
In the fifth week, sexually indifferent gonads start to develop. The onset of the gonadal anlage is identical in both genders. Medially of the mesonephros, the urogenital fold forms out of proliferating coelom epithelium and adjacent mesenchyme.
At the end of the fifth week, the primordial germ cells or primordial gametes migrate out of the endodermal wall of the yolk sac. by means of amoeboid movements, they pass the hindgut and finally reach the urogenital folds. From this point on, they are referred to as gonadal ridges. Gender-specific gonadal development begins at around week seven.
Male Gonad Development: Development of the Testicles
If the embryonic chromosome set contains a Y-chromosome, further development of the gonadal anlage forms the testicle. The testis-determining factor (TDF), a transcription factor, is responsible for this. This is encoded by the SRY-gene (the sex-determining region of the Y-chromosome) on the Y-chromosome.
Initially, the so-called primary sex cords, belonging to the coelom epithelium, grow into the mesenchyme, going deep into the marrow and losing contact with the surface. Here within the marrow, they condense, branch, and are surrounded by a connective tissue capsule, the tunica albuginea. The following primary sex cords form:
- convoluted seminiferous tubules
- straight seminiferous tubules
- rete testis
At first, the seminiferous tubules do not have a lumen. However, the septum of the tubules contains Sertoli cells, which consisting of germinal epithelium, next to the immigrated primordial germ cells. The Sertoli cells inhibit the germ cells, now called spermatogonia, from entering the prophase of meiosis. They produce the so-called anti-Müllerian hormone (AMH), a glycoprotein, which influences the development of the genital ducts.
Furthermore, this is where the testosterone-producing Leydig cells are found. These are intermediate cells, which have developed from mesenchyme and are of essential importance in the further development of genitals, due to their ability to produce testosterone. With the onset of puberty and the further development of the germ cells, the tubules are canalized.
When the mesonephros regresses, parts of its tubules remain. These tubules are referred to as efferent ducts of the epididymis and are connected to the rete testis. As when the mesonephros produces urine, they have access to the mesonephric duct or Wolffian duct, which transforms into the epididymal duct.
Development of the Female Gonads: Development of the Ovary
The development of ovaries is usually slower than the development of testicles. Similar to the development of testicles, it begins with the inward growth of primary sex cords from the germinal epithelium into the mesenchyme. Just as with the development of testicles, the rete ovarii form, which usually regresses completely. Also, a tunica albuginea is formed in the ovary, but this is significantly thinner than in the testicle.
In the 12th week, additional, so-called secondary sex cords start to grow. However, they do not grow as deeply into the mesenchyme and separate the cortical from the medullary area. The oogonia, the germinal cells that have immigrated, proliferate greatly within this cortex.
In the 16th week, the sex cords begin to lose their coherence and form cell clusters, which surround the individual oogonia as flat follicular epithelium cells. The oogonia have been developing into primary oocytes since the 13th week. The complex formed from an oocyte and the surrounding layer of the follicular epithelium is called a primordial follicle.
During the prenatal period, numerous primordial follicles form. However, a lot of these follicles regress before birth. At birth, roughly two million oocytes are present in the ovary. Postnatally, no more oocytes are created. The oocytes are kept in the diplotene of the prophase until puberty.
Development of the Genital Ducts
Initially, the development of the genital duct likewise exhibits a sexually indifferent stage. During this stage, the Mullerian ducts or paramesonephric ducts develop out of the epithelium laterally to the Wolffian ducts. At the end of the seventh week, they fuse caudally to form the uterovaginal canal and are connected to the dorsal wall of the urogenital sinus. This is where the so-called sinus tubercle or Mullerian tubercle develops. The influence of testosterone, emanating from the Leydig cells and the anti-Mullerian hormone emanating from the Sertoli cells, is crucial for further gender-specific development.
Development of the Male Genital Ducts
The production of testosterone induces the formation of male genital ducts. The following structures develop from the mesonephric duct:
- the epididymal duct: from the proximal sections of the Wolffian duct
- the deferent duct: from the distal sections of the Wolffian duct
- the seminal vesicle: from epithelial budding, directly in front of the entrance to the cloaca
- the ejaculatory duct: from the section between the junction of the seminal vesicle and the urethra
The epididymal duct is the convoluted duct system of the epididymis, which is surrounded by mesenchyme and is located at the cranial pole of the testicle. The efferent ducts lead to the epididymal duct. The distal section, which becomes the deferent duct, is surrounded by a layer of smooth muscles.
The prostate develops out of the epithelium of the urethra by growing into the attached mesenchyme. This also forms the smooth muscles of the prostate. The bulbourethral glands, or Cowper's glands, develop in the same way; they are epithelial buddings of the urethra, which grow into the surrounding mesenchyme.
Under the influence of the anti-Mullerian hormone, the Mullerian ducts regress almost completely. Frequent remains are:
- appendix testis: cranial remnant of the Mullerian duct at the testicle
- prostatic utricle: small remnant of the vagina in the prostatic part of the urethra
- seminal colliculus: rudimentary equivalent to the Mullerian tubercle
Although in men the mesonephric duct develops completely, some remnants may remain. This includes the appendix of the epididymis from the cranial end of the duct, and the paradidymis, the caudal remains of the mesonephric tubules, which have not developed into efferent ducts.
Development of the Female Genital Ducts
The development of the female genital ducts can be traced back to the absence of the Y-chromosome and, hence, to the absence of testosterone and the anti-Mullerian hormone. Further development of the Mullerian ducts occurs, along with regression of the mesonephric ducts, leading to the formation of the female genital ducts.
The unfused proximal sections of the Mullerian ducts form the fallopian tube, whose proximal section opens into the abdominal cavity. With the onset of puberty, ovulated oocytes are accommodated here.
The fused caudal part of the Mullerian ducts becomes the uterovaginal canal, which goes on to form the upper part of the vagina and the uterus. The uterovaginal canal leads to the urogenital sinus at the Mullerian tubercle. This is where two epithelial buds or the sinu-vaginal cusp of the endoderm of the urogenital sinus grow together into a solid, completely closed vaginal plate. This separates the uterovaginal canal from the urogenital sinus.
The subsequent vagina is formed by means of the development of a lumen via degeneration of numerous cells in the center. The vagina is separated from the urogenital sinus by a thin hymen.
When the Mullerian ducts fuse, they drag their peritoneal attachment with them. A peritoneal fold, referred to as the broad ligament of the uterus, is thus formed. Between the two sheets of tissue belonging to this structure, the so-called parametrium is found, which is made of mesenchyme. Two important pouches form at this location and are bordered by peritoneum:
- the recto-uterine pouch (pouch of Douglas)
- the vesicouterine pouch
The female embryo also develops glands from epithelial buds, which grow into the mesenchyme. These are the urethral glands, the equivalent of the prostate and the associated paraurethral ducts, or Skene's ducts, and the major vestibular glands, or glands of Bartholin, which correspond to the bulbourethral glands.
During regression of the mesonephric ducts, due to the absence of testosterone, some parts may remain, namely the appendix vesiculosa at the cranial end, the epoophoron with the remains of the mesonephric tubules in the mesovarium between the ovary and the fallopian tube, and the paroophoron with remains of the mesonephric tubules close to the uterus in the mesovarium. Gartner's duct is a rudimentary equivalent of the deferent duct and the ejaculatory duct. Gartner's duct cysts sometimes form here.
Rudimentary remains of the Mullerian duct are also sometimes seen in women. They develop at the cranial end, which is not employed by the fallopian tube. This vesicular structure is referred to as hydatid of Morgagni.
Development of the External Genitals
In a like manner, the development of the external genitals begins with a sexually indifferent phase. By the 12th week, the differentiation of the two genders is complete. In both genders, the following structures develop during the indifferent phase:
- the genital tubercle: ventral to the cloacal membrane
- the genital or urethral folds: on both sides of the cloacal membrane
- the labioscrotal swelling: lateral to the genital folds
The urogenital membrane, which seals what will become the urogenital orifice, is found between the genital folds. It ruptures about one week after the urorectal septum has developed together with the cloacal membrane, and leaves the orifice open. In both genders, the genital tubercle initially grows in length, to become the phallus.
Development of the Male External Genitals
The development of the male external genitals can also be traced back to the influence of testosterone on gender. First of all, the phallus develops into a penis. After this, it drags with it the genital folds, which have not yet fused at the lower side. The resulting groove is called the urethral groove. At this point, the urethra does not end at the tip of the penis but instead at its inferior surface.
The genital tubercle forms the glans penis at the tip of the penis. Out of the glans, ectodermal cells grow towards the urethra. Eventually, this cell cord becomes canalized, with the genital folds growing together on the lower surface, and the elongated urethra gaining its new orifice at the tip of the penis.
The cavernous bodies, as well as the spongy body, originate from the mesenchyme. The foreskin or preputium develops by means of circular growth of the glans penis. It is therefore of ectodermal origin, and it covers the glans penis. By means of fusion, the labioscrotal swellings become the scrotum. This is divided by the scrotal septum. The descent of the testicles into the scrotum normally occurs before birth.
No satisfactory answer has been found as to why this so-called testicular descent occurs. It is believed that body temperature is too high to allow maturation of sperms, leading to the testicles being relocated to the outside. During the testicular descent, the testicles take along all the layers of the abdomen, which explains the complexity of the testicular layers. The gubernaculum testis, a cord made of connective tissue situated between the testicle and the scrotum, guides the descent.
Development of the Female External Genitals
No complete explanation has been found as to what leads to the formation of the female genitals. Estrogen may be responsible. In a female fetus, the phallus does not grow any longer and remains as the clitoris. The genital folds fuse only in their posterior section to form the frenulum of labia pudenda. They become the labia minora.
The labioscrotal swellings fuse at the front and back, where they form the anterior and posterior commissure of the labia and the mons pubis. They become the labia majora. The ovaries also make a descent, which is guided by the gubernaculum. This descent, however, finishes within the lesser pelvis. The gubernaculum becomes:
- the suspensory ligament of ovary
- the proper ovarian ligament
- the round ligament of uterus
Pathological Genital Development
Malformations of the genitals may either have a chromosomal basis or may occur during various phases of development. The consequences may consist of small changes or, in rare cases, complete agenesis of the external genitals. The most important malformations are described below.
Klinefelter-Syndrome: XXY
In Klinefelter-Syndrome, the developing organism has two X and one Y chromosome. Those affected have a male phenotype, but exhibit, for example, female breast growth and are sterile due to the incorrect development of testicles.
Turner Syndrome: X0
People affected with Turner syndrome have only one X chromosome so that their genotype is described as X0. The phenotype is female. However, the female gonads are incapable of functioning. Typical indicators are dwarfism, pterygium colli, low hairline, and sterility.
True Hermaphroditism
In this case, both XX and XY sets of chromosomes and XX/XY mosaics can be present, with the first scenario being the most common. Humans who have this set of chromosomes develop both ovaries and testicles. Sometimes a condition called ovotestis is present, whereby both ovarian and testicular features occur in the same gonad. The phenotype and the external genitals can be female, male, or intersexual. True hermaphrodites often have a female physiological identity.
Both masculine and feminine forms exist. The feminine form describes people with an XX-set of chromosomes, and whose adrenal gland produces too much testosterone. Despite having normally-developed ovaries, these women can develop male external genitals in different manifestations. On the other hand, the masculine form relates to people with an XY set of chromosomes who produce too little AMH or testosterone. This results in varying degrees of insufficient development of the testicles and the external genitals.
Hypospadias and Epispadias
If the genital folds do not fuse around the urethra in the development of the penis, a urethral orifice at the lower surface of the penis results. This is referred to as hypospadias. Malformations in mesenchyme and ectoderm can lead to a dorsal location of the genital tubercle, with the urethra terminating at the dorsal side of the penis. This is referred to as epispadias.
This means undescended testicles, which can in principle occur at any point during the descent of the testicle. One frequent ectopic location for a testicle is in the inguinal canal. Until shortly before birth, this does not constitute a pathological state! Only after completion of the first year of life does this state impair further development and result in sterility.
Androgen Insensitivity
Also referred to as testicular feminization, androgen insensitivity is the absence or lack of androgen receptors. Thus, the female genital ducts regress, whereas the male genital ducts do not develop correctly. The clitoris and labia majora develop as external genitals, resulting in an inconspicuous female phenotype, despite the presence of XY chromosomes. In puberty, however, menarche does not occur. Despite the presence of the Y-chromosome, the physiological identity of these individuals is female.
Uterus duplex and Uterus bicornis
If the two Mullerian ducts do not fuse or do not completely fuse, a more or less separated uterovaginal canal is present. Uterus duplex refers to the formation of a double uterus with one or two vaginas. If only the upper part of the uterus is doubled, it is termed as uterus bicornis.
Review Questions
The answers can be found below the references.
1. Which of the statements below is correct? The genital tubercle…
- …lies dorsal to the cloacal membrane.
- …later becomes the labia majora.
- …is a pathological structure.
- …becomes the scrotum.
- …becomes the phallus in both genders.
2. The epididymal duct…
- …develops from the proximal section of the Wolffian duct.
- …is situated in the testicle.
- …develops from the distal section of the Wolffian duct.
- …is a remnant of the mesonephric tubules.
- …develops from the Mullerian duct.
3. Which of the statements below is false?
- The gubernaculum guides the descent of the testicle.
- The body temperature is probably too high for the maturation of sperm.
- The suspensory ligament of the ovary develops from the epoophoron.
- The expression of sexually indifferent gonads refers to the equivalent development of the gonads in the beginning of embryonic development.
- The primordial germ cells migrate into the gonads across the intestine.


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