text:
Dare I say it, only a few weekends left of summer! At least in Chicago that means something. When I lived in Southern California, you didn't count down the days until winter. Winter, what was that other than slightly colder days. But since I moved to Chicago and let's be honest gotten older, my swimsuit … Continue reading
Tag Archives: colored bags
What to Wear: Festival Fun
Long hot days listening to music definitely call for comfort. But as we all know, that can mean different things to different age groups. Although I check the 40-50 box, I still like to get my festival fun outfits ready! Unlike many of the 20-30 year olds, I don't like to dress like the generation … Continue reading
Design and The Art Fair
Last weekend, Brynn along with her three interns endured the heat at the Wells Street Art Festival in Chicago. As a new design intern, it was very interesting to see the different reactions and body language from a diverse group of people at Wells Street. What intrigued me the most was seeing what exactly influences … Continue reading
What to Wear: Summer in the City
When it's hot, hot, hot, there are definite must haves. Especially now that festival season has officially started, at least here in Chicago! Hat + Sundress + Sandals = go-to essentials for summer art festivals. This weekend was so hot, I wish I had brought a hat and better shoes! Flip flops are nice at … Continue reading
A day in the life of a new Brynn Capella intern
I just began my spring internship with the charming Brynn Capella. I'm a fashion business major at Columbia College Chicago and I am focusing on learning more about fashion merchandising within the Brynn Capella empire. I'm only two weeks in and I've already learned so much of the inner workings of a small independent brand, … Continue reading
Suede and Synergy.
There are a ton of exciting things happening in the Brynn Capella studio! Not only are we prepping the line sheets for our Spring 2017 collection to show to retailers, but we have also officially finalized our Fall 2017 leathers. Picking the leathers has been a unique challenge. There were a few times that we believed we had finally … Continue reading
Color, Texture, and Bliss.
Last week we had a great time participating in the semi-annual One of a Kind Show! As we continue to design the Fall 2017 collection from Brynn's studio, I was curious to see what people would be looking for when an entire collection was presented to them. I noticed that often, shoppers were drawn to … Continue reading


text:
The website that has been exchanging porn for pictures of dead Iraqis is in trouble, or at least the man who runs it is in trouble:
Polk County officials arrested a Lakeland man on obscenity charges Friday after investigating his graphic Web site, which has gained international attention for allowing U.S. soldiers to post pictures of war dead on the Internet.
The charges against Christopher Michael Wilson, a former police officer, are likely to reignite the debate about obscene material in the Internet age. It also raises questions about whether the federal government played a part in motivating the prosecution.
Polk County Sheriff Grady Judd said late Friday that the 300 obscenity-related charges against Wilson all involve sexual content on his Web site -- and not graphic war-scene images posted by soldiers.
"It is the most horrific, vile, perverted sexual conduct," Judd said. "It is as vile, as perverted, as non-normal sexual conduct, which rises to the level of obscenity, as we've ever investigated."
Late last week, U.S. Army officials said they could not confirm whether photographs on Wilson's Web site, presumably showing Iraqi and Afghan war dead, were actually posted by U.S. soldiers.
An Islamic civil-rights group was disappointed that the Army did not pursue criminal charges. Last week, Ibrahim Hooper, a Council on American-Islamic Relations spokesman, said: "For this to be treated in a manner that suggests the Army does not take this seriously is only going to further harm our nation's image and interests around the world, particularly in the Muslim world."
Wilson, 27, was letting soldiers access normally paid portions of his site in exchange for graphic war-scene shots or proof that they were fighting in the Middle East, for instance. Late Friday, Wilson's site, which the Orlando Sentinel will not name, still had grisly images of war dead.
Judd said none of the 20 films and 80 photos that brought about the charges involves pictures of war dead. But Judd confirmed that his detectives did speak with officials with the U.S. Army Criminal Investigation Division before arresting Wilson on Friday.
Disgusting stuff. The reactions (in the comments sections) to these news both on Americablog and on Eschaton are worth reading. The consensus appears to be that the display of dead Iraqis is horrible and that for Wilson to be arrested on obscenity charges for the ordinary porn part of the site is hypocritical. Also, many point out that porn is legal and all over the internet, that the authorities in this case seem to be arguing that sex is dirty and showing dead corpses is not. I can see the truth in these arguments.
It certainly is hypocritical to behave as if dead corpses are somehow ok to view and porn is not. But it might be enlightening to ask why a website trades in both kinds of pictures. What is it that the two might share, at least in the case of some types of "ordinary" depictions of porn? Could it be the pleasure of observing how violence works? The pleasure of humiliation, of making a person into a thing? The pleasure of the ultimate power of unmaking a human being?
Not all porn is like this, of course, and not even the majority of porn, but there is a narrow edge to pornography which definitely serves the same kinds of instinct as come into play with those who enjoy watching torture, for example. I have not visited the war-porn website, so I don't know if any of my guesses are correct. But the feelings of disgust and fear I have experienced from seeing violent pornography are not really any different from those I experience when I come across a really horrible picture of a war victim, except that I try to persuade myself in the former case of it all being play-acting.
The point I am making in this piece is not the central one that the war-porn website elicits, and I don't pretend that it is. But it's a point worth making, I think.
Added on Sunday, thanks to mark from ireland in the comments, who pointed me to some blogs who have worked on this topic for a long time and who do talk about the central point in this sordid story: Go to Nur Al-Cubicle and Just World News to find out how this story is unfolding both in foreign media and possibly even in our own so-called liberal media. And to find out how horrible it all is.

subset: commoncrawl


text:
Mesa, AZ - With a win Tuesday afternoon, the #7 Mesa Thunderbirds are one victory away from claiming the #1 seed in the ACCAC DII Tournament which begins next Thursday, March 3rd.
The T-Birds used a big 5th, 6th and 8th innings offensively to take down the Artichokes, 13-3, in eight innings. Mesa scored three in the 5th to tie the game at three then put a crooked seven spot on the board in the 6th inning to take a commanding 9-3 advantage at that point.
It was then a Paul Steffensen triple, his 10th of the season which leads the NJCAA, with runners on first and second that solidified the run-rule victory. Steffensen would score on the play because of a Scottsdale throwing error to third.
On the day, that was Steffensen's only hit but he did knock in four RBI's on the afternoon, hitting a sacrifice fly in the 6th inning. Connor Denning went 2-4 with two doubles and three RBI's while Jace DeGrange went 2-3 with a triple. Luke Patty also had two hits on the day.
Cameron Doherty walks away with his fifth win of the season, pitching seven innings, allowing six hits, striking out two while allowing three runs. Tyler Hilton finished the eighth inning for the T-Birds, allowing just one hit and no runs.
The T-Birds push their record to 39-14 with a 23-14 ACCAC record. Mesa and Scottsdale will be right back in action tomorrow afternoon at Scottsdale with a 3 pm first pitch start.


text:
Image Magick installation problem
I have followed this instruction https://www.digitalocean.com/community/questions/problem-installing-imagemagick-ubuntu-14-04
to install ImageMagick, I did update but while I am installing ImageMagick it come with Error 2 at the almost end of the the intallation?
My droplet has Ubuntu 14.04 any idea, by the way ImageMagick-6.9.2-0.tar.gz does not work but I am installing ImageMagick-6.9.2-10.tar.gz
Any idea how to solved this issue?
Screenshot of the error


text:
Love it or hate it the final day of the transfer window once again got us scrambling to our refresh buttons, clicking on our televisions and nervously tuning in for any breaking news. It is one of the most tense and dramatic days of the year.
The reality is though nothing much happened.
Harry Redknapp was linked with pretty much everyone under the sun. Pompey looked to buy a squad back to make up for the one they have sold over the past 18 months, two people called Collins moved somewhere between Stoke, Sunderland and Villa and Everton signed Johnny Heitinga; which should upset the Premier league odds.
But that didn't stop Sky Sports News criss-crossing the country bringing all the latest breaking transfer news: "I can confirm David Bentley is not going to Man City," well thanks for that.
The channel really comes into its own when genuine news stories break. The 24 hour rolling news channel has become a symbol of today's instant demand for news, providing viewers with the stories as they happen. Last year's transfer window was an example of that when City were taken over, bid for about five different players and splashed out £30 million on Robinho, all in 24 extraordinary hours.
But when there isn't a lot happening the channel's attempts to hype up hot air really begins to grate. Jim White is the chief culprit; he could make boiling an egg sound exciting.
"Dharmesh Sheth I understand you have moved from Portsmouth's training ground to Fratton Park, what is that the significance of that?"
"Nothing Jim it is just sunnier here that's all."
All the hype was there. Andy Burton was on set with his phones, David Craig's mobile kept disrupting his \'North East' updates while Vinny O'Connor was mobbed by Everton fans outside the club's training ground. A new graphic introduced was the transfer fee ticker, like some sort of charity fundraiser, clocking up thetotal transfer fees spent this summer (most of it by City). The whole day was capped off by the chimes of Big Ben, ending all the chaos.
Why the moan you may ask?
Because as trashy as it was I couldn't switch it off!
I was transfixed at the TV, waiting for the deals to come through.
The same reason we keep going to the games. The same reason we renew our season ticket even after a poor year: Hope.
Hope that things will get better is the staple diet of the English football fan. Sky Sports increase that hope by fogging the lines between rumour and reality. We don't know what is true and what isn't, but as long as we tune in they don't care.
And to be honest as much as we whinge and moan, we don't care either.


text: Quick Links Tweet This resource has undergone expert review. Resource Overview Time Allocated 1-6 lessons Links to National Curriculum ACPPS073 (Yr 7–8)ACPPS076 (Yr 7–8)ACPPS095 (Yr 9–10)ACPPS096 (Yr 9–10) Origin International Cost Free Mouse Party AvailableAccess Mouse Party Year: Year 9–10, Year 11–12 Targeted Drugs: Alcohol, Cannabis, Cocaine, Hallucinogens, Heroin, "Ice" (Methamphetamine), Methamphetamine, "Party Drugs"/MDMA/Ecstasy DevelopersUniversity of Utah, Genetic Science Learning Center, USA. SummaryPlayers take a look inside the brains of mice that are under the influence of different drugs. The chemical interactions at the synaptic level are explored. Format20-minute interactive learning experience. Expected Benefits Increased general knowledge of drug(s) Increased knowledge of drug-related effects and harms. Evidence BaseThe game has been reviewed and won the Science 2010 prize for online resources in education. See: Stark, L. A., & Pompei, K. (2010). Making genetics easy to understand. Science, 327, 538-539. doi: 10.1126/science.1183029 Page last reviewed: 8 November 2019. Print: Mouse Party


text:
Panama City Beach continues to be the reigning spring break capital of the world, but for how much longer?
Local officials seem to have reached a breaking point with the college students' behavior and are preparing to institute some major changes.
But to see where we're going, it may help to see where spring break's been.
Panama City Beach is not the first Florida city that's attempted to tame spring break.
Historians joke that spring break can be blamed on the ancient Greeks and Romans, who celebrated the arrival of spring by worshipping the gods of wine, but the history of the spring break as we know it begins years later, on the other side of the world.
Fort Lauderdale, Florida, in the 1930's.
Swim coach Sam Ingram brought his team to the only Olympic-sized pool in Florida.
Teammates told friends about their Florida retreat, and by 1960 Fort Lauderdale began seeing an influx of spring breakers.
A 1961 film entitled "Where The Boys Are," brought even more attention to the area, and by 1985, almost 400,000 students crowded "Fort Liquordale" each year.
MTV even launched a new spring break show there.
But when predators began following spring breakers to the area, city commissioners cracked down on alcohol restrictions, ending the beach's reign as "spring break capitol".
In 1986, MTV moved spring break to a more permissive beach: Daytona.
Three hundred fifty thousand students traveled there each spring during its peak in the late 1980's, but by the late 1990's, Daytona's local government also banned alcohol on the beach.
Spring break campaigns began targeting a new area.
"The old byline for Panama City Beach was after Labor Day and probably until the first of May, you could fire a cannon down Front Beach Road and wouldn't hit a single vehicle or soul," Guy Tunnell, Bay County Sheriff from 1989-2003, said.
But by the mid-1990's, the landscape on the gulf shores began to change.
"We started to see some pretty significant numbers and we had some real problems with the new designer drugs."
In 1997, MTV's spring break show led to a much more controversial series in Panama City Beach: Joe Francis' "Girls Gone Wild".
"That put a unique spin on it. That was toward the end of my career and I think that was the beginning of what we have seen now."
After Francis was arrested in 2003, after videotaping topless underage girls, the show left Panama City Beach.
But the party-scene remained.
Ten years later, current Bay County Sheriff Frank McKeithen says the backdrop grows worse each year.
"Most college students were like, 'Oh my god, my mother's gonna find out and I'm done for.' Now it's like, 'Eff my mother and eff the police,'" McKeithen said.
Only 217 sworn in deputies battle the spring break crowd of 500,000.
And all of them wear a bulletproof vest.
In 2013, dispatch created a new radio channel dedicated solely to spring break calls.
The sheriff's office moved its mobile jail to the beach, EMS stands by around the clock, and police officers are armed with riot equipment.
"We're better than this, I'll say that."
The real question is, 'How can we market Panama City Beach to attract guests besides college students?' Fort Lauderdale and Daytona still have a spring break. It's just smaller and more controlled, unlike the massive crowds that have crowned this area as the spring break capital.
Ft. Lauderdale absorbed the economic impact of losing spring break better than Daytona, which is smaller.
Panama City Beach City Council members plan to discuss new spring break ordinances at this next meeting next month.


text:
Recent Posts
Recent Comments
Monthly Archives: July 2011
Free Knitting Pattern: Easy Baby Cow Hat
This is a simple baby hat which requires you to be able to knit, purl, K2tog (knit two together) and be able to knit in two colours. If you haven't knitted in multiple colours before, this is an easy project to start you off! Just remember to twist the two colours around each other when you change colours otherwise you will end up with holes. All the pieces are knitted flat and then sewn together afterwards.
- Size 6 (4mm) needles
- Black wool
- White wool
- Brown wool
- Some stuffing
- A blunt needle
Posted in Free Knitting Patterns, Knitting Leave a comment


text:
To purchase PLAIN, HONEST MEN go to
amazon.com, barnesandnoble.com or
Richard Beeman is a professor of history at the University of Pennsylvania and the author of six books and several dozen articles on the history of revolutionary America; his biography of Patrick Henry was a finalist for the National Book award. (For more information on Professor Beeman's previous work click here). His most recent book, Plain, Honest Men: The Making of the American Constitution is the most comprehensive account of the Constitutional Convention to appear in the past half century; it will be released by Random House in March, 2009. The book takes readers behind the scenes and beyond the debate to show how the world's most enduring constitution was forged through conflict, compromise, and, eventually, fragile consensus.
Professor Beeman has served as Chair of the University of Pennsylvania's Department of History, Associate Dean in Penn's School of Arts and Sciences responsible for the School's humanities and social sciences departments, and as Dean of the College of Arts and Sciences. He is a member of the Board of Trustees of the National Constitution Center and is Chair of the Constitution Center's Committee on Programs, Exhibits, and Education. He serves as Vice-Chair of the Distinguished Scholars Panel of the Constitution Center and as a member of the scholarly advisory board of the American Revolution Center.
Dr. Beeman has received numerous awards, including fellowships from the National Endowment for the Humanities, the Rockefeller Foundation, the Institute for Advanced Study at Princeton, and the Huntington Library. He has served as a Fulbright Professor in the United Kingdom and as Vyvian Harmsworth Distinguished Professor of American History at Oxford University.


text:
Stephen works as the Outdoor Center Program Coordinator here at WWU. His position covers every aspect of the Outdoor Center, from WOOT to Excursions.
The Outdoor Center has numerous different programs running throughout the year. Some of these programs are WOOT, Excursions, and the EDGE Challenge Course. They all boast large attendance numbers, with Excursions having weekly trips of about nine participants, and the Challenge course working with 300-400 campus/community members per quarter. The WOOT program had about 150 student participants this year, which is massive growth from the original 63 when the program started in 2014. The Bike Shop is by far the busiest section of the Outdoor Center, with an average of over 50 students renting from the shop per day.
The Outdoor Center currently employs 60-80 employees throughout the year to keep up wit the busy schedule.
The Outdoor Center has also partnered with the Rec Program here at WWU for PE 105, and the American Alpine Institute for avalanche training courses. The Outdoor Center also works along side Remote Medical International for medical training courses.
If you are interested or want to find out more, you can visit the Outdoor Center website at: http://as.wwu.edu/outdoor/
Leave a Reply.
Staff Biographies
This page includes staff biographies of the DOS/AS Staff.
Want to see what else is happening in the DOS Unit? Take a look!
Program Highlights
Professional Development
Best Practices
Recognition & Awards
June 2017


text:
At least the weather can provide heaps of conversation and by now we are all stir crazy….
Look at this bright fabric called "Glamping" on the shelves now….
Not feeling chatty though at the moment, just over the heat and yes the tradies are still here, the roof is finished and l have told Mr PnQ to stop running around in his undies out the front(ooooooo), the possum well not sure whats happened there, he may have left the building……….
Heres to the cool change…..
Cheers Mary


text:
|Conception Mission Doorway by Jess Thompson
by J. Ruth Gendler
Guilt is the prosecutor who knows how to make every victim feel like the criminal. She follows the scent of doubt and self-hatred to its sources. She will not tell you what you have done wrong. Her silence is brutal. Her disapproval surrounds you in an envelope of cold nameless terror.
Guild thinks I am hopelessly lazy because I won't work the way she does. Her court cases are scheduled years in advance. She says horrible things about me to the neighbors. In self-defense sometimes I tell people what she says about me before she has the chance. I don't care as much as I did, but I can't pretend I don't care at all.
You may recognize Guilt's footsteps before you see her coming. She limps like a crippled bird. Even though her broken ankle is healing, the wound in her heart has become infected.


text:
Windows 7 OSD deployment (SCCM or MDT ) and starting with a patched media = More secure & Saves time !
July 27, 2011 at 9:03 am in ConfigMgr, ConfigMgr 2007, ConfigMgr 2007 R2, ConfigMgr 2012, ConfigMgr SP2, ConfigMgr V.next, configmgr2007, ConfigMgr2007 R3, Deployment, DISM, OSD, sccm, SCCM 2007, SCCM 2007 R2, SCCM 2007 R3, SCCM 2007 SP2, SCCM 2012, SCCM v.Next, sccm2007, WAIK, Windows 7, Windows 7 SP1, Windows7 by Kenny Buntinx [MVP]
1. Download your patches to a folder
You could always download the patches from the following link http://catalog.update.microsoft.com/v7/site/Install.aspx?referringpage=Home.aspx and save them to a local folder or automate it by the following process :
First step will be to install a clean Windows 7 machine without any application . After that process we will run wuauclt /detectnow and install all available updates . You will need to reboot a few times and rerun the wuauclt /detectnow to allow all patches to be installed properly
Then run the procedure below for WSUS patch extraction :
Go to C:\windows and open windowsupdate.log in excel. Delimit the file by Tab and space
Run the auto-filter and filter on "Downloading" in column "G"
Select all rows in column "I" and copy the table. Go to new sheet and paste in this in column "B"
We select column "B" and select Data -> text to column en delimit by '/'. Now we remove column "B,C,D and E"
Go back to sheet where you imported the "Windowsupdate.log" and select all rows in column "K" and copy the column. Go to the new sheet and paste in column "D"
We select column "K" and select Data -> text to column en delimit by '\'. Now we remove column "D,E,F,G and H"
Paste the following formula in column "A" "="Copy H:\" & B2 & "\" & C2 & " c:\Patches\" & D2"
Drag the formula to below , select column A , select all and copy it
Open notepad , paste the text and save as "getpatch.cmd"
Map your drive H: to \\yourwsusserver\WsusContent and run "getpatch.cmd"
Copy your downloaded patches to the location you need them
2. Applying the offline patches to the windows 7 media
Open up a WINPE command prompt via the WAIK.
Run the following commands in the following sequence .
Dism /Mount-Wim /Wimfile:"F:\DISM\Windows 7 Enterprise SP1 Eng X64 Source\sources\install.wim" /index:1 /Mountdir:F:\DISM\temp
Dism /image:F:\DISM\temp /add-package /packagepath:F:\DISM\Patches (where the patches folder contains your downloaded CBS windows patches)
dism /commit-WIM /Mountdir:F:\DISM\temp
dism /unmount-WIM /commit /Mountdir:F:\DISM\temp
3. What if you get an error applying the offline patches?
It can happen that there are patches that cannot be applied offline. When that happens, you will get the following error as shown below in the screenshot. In this case KB2533552. Do not worry, the process does not need to run again.
However, please note all patches that couldn't be applied, so you could keep track of them for later deployment .
To see what is really going on and to verify this is a patch that cannot be applied offline , you should open the DISM.log file and search for the specific update as shown below in the screenshot.
When you look closer at the screenshot, you will see the message "Cannot perform offline servicing with an online-only package ", meaning this patch is not a CBS update and needs to be applied online.
You could always check the update on the following link http://catalog.update.microsoft.com/v7/site/Install.aspx?referringpage=Home.aspx
4. Import the image in SCCM or MDT
After this process you need to import the source content in SCCM. When done start adding it to the distribution points and wait until it is replicated, preferably with a good naming convention.
After importing the image in SCCM, add it to the DP's and check if the image is replicated correctly on all selected DP's.
When it's done, change the media in the task sequence to use the new patched media. This will allow you to minimize staging downtime.
Now you are running from the start with a patched offline media , meaning less deployment time and being more secure when deploying your machines !
Hope it Helps ,
Kenny Buntinx


text:
One of my all time favorite actors (and millions agree), James Garner passed away of natural causes at the age of 86 this morning at his home in California.
Celebrities, royalty, filthy rich
"Magical" writer, Nobel-Prize winner "Gabo" García Márquez dead at 87
Gabriel García Márquez, the Colombian novelist whose "One Hundred Years of Solitude" established him as a giant of 20th-century literature, died on Thursday at his home in Mexico City, at the age of 87.
Wonderful excerpt from "Gabo's" obit in the New York Times:
Mr. García Márquez attributed his rigorous, disciplined schedule in part to his sons. As a young father he took them to school in the morning and picked them up in the afternoon. During the interval—from 8 in the morning to 2 in the afternoon—he would write.
"When I finished one book, I wouldn't write for a while," he said in 1966. "Then I had to learn how to do it all over again. The arm goes cold; there's a learning process you have to go through again before you rediscover the warmth that comes over you when you are writing."
Incidentally: "One Hundred Years of Solitude" is Bill Clinton's favorite book. If you haven't read it yet, you should, and investigate Gabo's other books, too. Adios Gabo!
Happy 86th birthday to James Garner!
One of my favorite actors. Many happy returns! Love, Madcap
Good Wife shocker and Oprah's ironic cover
Actor Josh Charles, of The Good Wife (on CBS) wanted to be released from his contract so the show's creators decided to go the Matthew Crawley route (Downton Abbey) by killing him off. Shocking, of course, but they wanted to stir things up. I'm sure all his fans wish Mr. Charles the best of luck.
Now, about Oprah:
O's April cover features her drastically Photoshopped in a 1970s flip wig, bulges removed, slenderized, with almost gamine-like legs, and looking 25 or 26 instead of 60. Oprah's ability to manipulate reality has always fascinated me but what struck me is the cover's irony.
Oprah constantly lectures about the importance of being "authentic," yet anyone who watched her in "The Butler," or during recent TV appearances knows she's not thin, not even close. For a while O was celebrating her shape, however plump and puffy, and I respected that. However this cover screams disingenuous.
Wish I'd had money on the Oscars race
I followed all the pundits' Oscar predictions so thoroughly I could have hosted the show and sure enough every one was right. I'm not too shy to say I thought DeGeneres was off her game this time, I hated the pizza business, which went on too long, and didn't like the set design: ugly recycled dusty water bottles in the shape of Oscars. WTF?
Oscar-winner Liza Minnelli and 1950s screen legend Kim Novak were absolutely scary. Poor Liza was in her jammies and someone has removed Ms. Novak's cheekbones and broken her jaw. "Why can't they age naturally?" my sweet husband asked. Think Judi Dench.
Whoopi was wearing what I can only assume was a painter's tarp and brown cotton fabric from Michael's. Too hideous for words. Is it intentional? And I was not amused with her Cat in the Hat stripped socks and Wizard of Oz ruby slippers.
And the short guy wearing Bermuda shorts, accompanied by the tall drink of water girl. OMG! Horrible!
What I did like: all four top Oscar winners gave sane, sober and articulate acceptance speeches. Bravo!
My favorite gowns were Sandra Bullock, Cate Blanchette, Kate Hudson, Pink's red dress, Anne Hathaway, Charlize Theron, Camila Alves, and Bette Midler's darling Red Carpet frock. By the way I loved Bette's song tribute.
The best jewels of the night were the $15 million dollar Harry Winston rocks worn by Ms. Theron. Zooie!
Grateful the Academy had the smarts to have lucid younger stars escort and assist some of the ailing antiques: pairing Ms. Jolie with a fragile-looking Sidney Poitier, and a dithering Kim Novak with Mr. McConaughey.
Hoping next year they'll entice Billy Crystal back to MC.
I'll settle for thirty-five
"Botox and fillers, she said, "make the younger people look old and the older people look young. Everyone looks like a homogenized 35."—writer Carole Radziwill in a New York Times interview Feb. 26.
Oops! Forgot "Heidi" in my Shirley Temple tribute
How could I forget Shirley in one of her iconic roles as the orphaned heroine of Johanna Spyri's beloved children's book? The 1937 film featured a host of character actors and actresses in memorable supporting roles, including Jean Hersholt, Arthur Treacher, and frequent co-star Mary Nash.
Watching "Heidi" is a tradition in my family that continues to this day. Even my Mexican-born husband loves the movie and its adorable star and I remember my father making us laugh with his impression of "The Grandfather" as he searched for Heidi, who'd been sold to the gypsies by her evil aunt.
And who can forget the Heidi football game debacle of 1968 when some genius at NBC cut off the last 68 seconds of play between the Oakland Raiders and New York Jets in favor of airing "Heidi?" Don't you love it?
"So many irate fans called NBC that the network's switchboard blew. Undeterred, people started calling the telephone company, the New York Times and the NYPD, whose emergency lines they clogged for hours.
Shortly after the Heidi debacle, the NFL inserted a clause into its TV contracts that guaranteed that all games would be broadcast completely in their home markets. For its part, NBC installed a new phone–the "Heidi Phone"–in the control room that had its own exchange and switchboard. Such a disaster, the network assured its viewers, would never be allowed to happen again." –from History.com.


text:
Jennifer Niven, first of all, how dare you. Secondly, ouch. Lastly, thank you. Niven delivers the most beautifully composed and relevant YA novel the genre has seen in a long time. — Briana, age 22, Orange, CA
Profound and meaningful, yet still something teens will want to read and understand. . . . I literally could not put this book down. — Regan, age 15, Long Island, NY
A story that demands to be read. Filled with searing clarity and messy, confusing love, All the Bright Places is everything young adult contemporary can and should be. Fiercely original, hard-hitting, and courageous, it's an emotional roller coaster that pierces the heart and captures the imagination. It's brutally honest and brilliantly written. Jennifer Niven is an incredible new voice in teen fiction. Extraordinary. —Arianne, age 14, Ireland
All the Bright Places will warm your soul, then tear it apart and . . . settle in the brightest place of your heart. — Steysha, age 19, Kiev, Ukraine
All the Bright Places hit me in the feelings and never let me go. I laughed, cried, fumed, and wished I read this when I was 15. More than anything, it reminded me of how important people are, and how important it is to get out of our own heads and care deeply for someone else. — Brittany, age 22, Los Angeles, CA
Time received: 11 am. Time finished: 10:47 pm. . . . My heart was just torn into pieces. Complex. And heartbreaking. I couldn't stop reading till I finished. And I did. And yeah. And my goodness. . . . It was amazing. — Annalise, age 15, Holly Springs, NC
You know what book is freakishly awesome? #AlltheBrightPlaces by @jenniferniven. I CANNOT PUT IT DOWN. — Cait @NotebookSisters
Was lucky enough to get a proof of #AlltheBrightPlaces — beautiful, heartbreaking book. One of the best I've read this year. I'm in pieces after it. All The Bright Places will be published in January 2015, and EVERYONE needs to read it. It's stunning. — Louise O'Neill (author of Only Ever Yours)
No words. So many feels. — Kristy @KristyBookNerd
Adored #allthebrightplaces. The only new YA novel I've heard compared to @realjohngreen that deserves it. — Jocelyn @jocelynbm
All the Bright Places is freaking phenomenal. Love, love, love. — Alex Colevas @alexlikesbooks
Tissues, tissues. Loved it. — T. Greenwood (author of Bodies of Water, Grace, Two Rivers)
I just wanted to keep reading about Violet & Finch, but at the same time I never wanted it to end. It is one of the most beautifully written books I have ever read, and definitely belongs on the Saddest Books Ever and the Best Books Ever List.— Mathilde Tobin @Mathilde_Tobin
OMG OMG OMG!!! This book was so good. It was spectacular. I sat down on my bed to read it and didn't look up until two hours later when I had finished. Tears were streaming down my face, it's that emotional/well-written/beautiful. Read it when you're happy or sad or mad, just read it. Sit down and don't get up until you know all of Finch and Violet's story. Once you've laughed and cried with them, you'll feel a little more human. — Jordyn, Bunnies and Books
Stunning. The YA bar just got raised a country mile. Thank you @jenniferniven — Phil Earle (author of Being Billy, Saving Daisy, and Heroic)


text:
From the "Mailbag": Which Fast is "Easier," Western or Eastern Rite?
This is actually a compilation of a number of e-mails asking me to compare the Eastern and Western fasting practices and a direct question someone broached in person; hence, "mailbag" is in quotation marks above. The question I am continually asked is which rite's fast is "easier" (as though such a thing could be judged, or would be spiritually edifying if it could).
My studious answer is: It all depends. According to the Antiochian usage (more about ROCOR WRITE later):
In the Western Rite, one could, perhaps oversimply, summarize the fasting and abstinence rules (which should be read in full here) by saying the emphasis is put on the amount of food eaten and the times of abstinence required. The simple version is those physically capable should eat one (or one-and-a-quarter) meal a day, not before the afternoon, even on fasting days outside penitential seasons. The variety of food permitted is also more closely regulated during Lent and Advent than during the rest of the year, but the outstanding feature (to my humble reading) is abstinence and moderation: that one literally deprive himself of food.
In the Byzantine Rite, again perhaps oversimply, one can say the emphasis is placed on the kinds of foods eaten. Sometimes the guidelines do not mention restricting the amount of food eaten, sometimes they do (during Lent). [1] In practice, the emphasis in most Orthodox churches of any jurisdiction seems to be that one may not eat meat, dairy, fish, wine, or oil, though one may eat shellfish or vegan fare, with little mention made of amount.
So, which is more difficult: giving up certain foods or limiting the times and amounts of food?
At the risk of wearing out one of my favorite phrases: The Church's two rites are just different ways of doing the same thing. Think of them as two sides of one coin. Both are forms of purgation — and sensible adjustments to both amount and variety of food should be combined in an ascetic fast. Coptic Pope Shenouda III has written an important statement to those who emphasize the kinds of food permitted:
A period of abstinence is essential, since we would simply be vegetarians if we ate without observing it from the beginning of the day. The word fasting means abstinence or cessation. It is therefore necessary to refrain from eating for a certain period of time.Similarly, it's important not to indulge our favorite foods, even if they are permissible, as the fast is meant to starve our appetite for pleasure and restore our food's proper role as a building block of life, not life's end.
Both concepts are important — but not as important as what gets lost by those who obsess over the legalistic, physical requirements about how a true Christian should never eat before afternoon (but deprives himself none of his favorite foods) or how a true Christian never eats meat during Lent (but helps himself to seven plates of spaghetti a day). Adherence to the letter of the law allows indulgences of another kind. Some Orthodox churches even host "all you can eat" seafood buffets during Lent. [2] Worse, though, are the indulgences of pride and self-satisfaction we find in condemning those we deem less "rigorous" than ourselves (and of course, our fasting is always the most rigorous). What is this but Publicanism: "God, I thank Thee that I am not like other men"?
The Antiochian Archdiocese adds the vital part of fasting is not pharisaically peering into various rules and regulations (and ajudging others insufficiently attentive or overly harsh). Fasting is a tool that must lead to our metanoia and metamorphosis:
Fasting is more than not eating food. Saint John Chrysostom teaches that it is more important to fast from sin. For example, besides controlling what goes into our mouths, we must control what comes out of our mouths as well. Are our words pleasing to God, or do we curse God or our brother?As some of the saints note, the demons never eat nor sleep, yet they are helped not one whit by it. By becoming free of our dependence on food, particularly as a form of entertainment (!), we are freer to act in accordance with our own nature. We lessen the grip the flesh has over us and gain the freedom to respond in the spirit, "For the flesh lusteth against the Spirit, and the Spirit against the flesh: and these are contrary the one to the other; so that ye cannot do the things that ye would" (Gal. 5:17). Strengthened in the inner man, we can respond more readily and completely to Christ's ceaseless overtures of love.
The other members of the body also need to fast: our eyes from seeing evil, our ears from hearing evil, our limbs from participating in anything that is not of God. Most important of all, we need to control our thoughts, for thoughts are the source of our actions, whether good or evil.
Fasting is not an end in itself. Our goal is an inner change of heart. The Lenten Fast is called "ascetic." This refers to actions of self-denial and spiritual training which are central to fasting.
The Orthodox Church's different approved fasting regulations should not become a cause of strife or condemnation of our brethren. (In the stirring words of the great St. Ephrem the Syrian, which the Byzantines pray during Lent, "Grant me to see my own errors and not to judge my brother.") They should inspire us to follow our own approved discipline, with the principles of true fasting undergirding both halves of our Church. Thus, we will live a balanced and transformative fast, maturing from glory to glory in Christ, which is His wish for us (Eph. 3:14-21).
1. The Antiochian Archdiocese adds some emphasis on the amount of food to be consumed, recommending total fasting during certain periods of Lent. "According to what was done in the monasteries, one meal a day is eaten on weekdays and two meals on weekends of Great Lent." However, "No restriction is placed on the amount of food during the meal."
2. I decided against adding a link to such a parish, because I didn't want to single any church out...but I've seen a number; do a Google search if you want proof of this phenomenon.


text:
It is one of the most sought after things in America. Whether you're a man or woman, young or old: everyone wants a beautiful smile. Your smile is one of the first ways you make an impression on others, it can tell them a lot about you – including how well you take care of yourself. It is, therefore, important to take good care of your oral hygiene to avoid health complications and make a good first impression, whether it's on a date or for that big meeting. Having a bright smile not only makes you look better, but also makes you feel and act confident. Acquiring a better smile isn't always hard, building good consistent habits can go a long way.
Here a some basic ways to make sure you have a good smile, brought to you but Dr. Mott.
Brush Regularly
One of the best ways to clean your teeth is through brushing habitually. This may seem obvious, but just because you already knew it doesn't mean you practice it! Brushing your teeth is extremely important to do every day, twice a day. It helps to remove food particles that stick to your teeth after meals that encourage bacteria and tooth decay. Brushing your teeth will keep your teeth clean and your breath smelling good. It is helpful to brush your teeth after meals as well. If your dentist, such as Dr. Mott, prescribes fluoride toothpaste because of soft or decaying teeth, that can also help prevent unsightly tooth decay. Be sure to use soft bristled toothbrushes, and be firm but not too harsh while brushing your teeth.
Another obvious one! However, even less people follow this basic step to improving their smile. Flossing is important for keeping the area between your teeth clean and healthy. Flossing reaches the areas of your mouth that plaque, food particles, and bacteria are likely to accumulate. Flossing regularly will curb gum diseases and keep you healthy. It is recommended by Dr. Mott to floss at least once a day preferably before you go to sleep.
Visit your Dentist
Going for thorough checkups is crucial as it enables the dentist to sense any problem at an early stage so that he or she can catch it and fix it before you need major work done. It also allows the dentist to give you your bi-annual lecture so that you're more likely to stay on top of your brushing and flossing. You could also take some time to examine your mouth yourself. This is simple: you could start by looking to see if you have swollen gums, bleeding gums, or any other unusual thing in your mouth. Consult your dentist, such as Dr. Mott, on what you should look out for.
It is essential to make your diet as healthy as possible: incorporate foods that are rich in calcium and vitamin C. This is because calcium strengthens both bones and teeth. Vitamin C also enhances the health of the gums. Ensure that your meals are free from sugary foods and if they are it is best to brush as soon as possible.
Don't Smoke
Smoking poses risks of gum diseases and bad breath. Smoking causes mouth cancer and can severely affect the health of your gums and teeth. Additionally, the effects of e-cigs are unknown and may have similarly harmful effects so it's best to stay away from those.
Whiten Teeth
Whitening teeth is a safe and very common procedure. You can get kits from target, or you can get teeth professionally whitened if you feel that it is necessary. You should also seek the dentist's guidance if your teeth have severe yellowing. It is also of importance to consult your dentist prior to beginning any whitening process.
Cosmetic Procedures
Having crooked, discolored or missing teeth can alter your image and confidence. If you really want a solution to something that can't be fixed by keeping good habits, you may want to consider a cosmetic procedure such as implants or braces.
Achieving a great smile by keeping healthy habits is entirely doable, and it will also keep you and your mouth healthy. Following the tips provided will ensure that you keep that sparkling smile for years to come. If you need a checkup, advice, or a cosmetic procedure, contact Dr. Mott today and learn how you can achieve the smile of your dreams.
Photo Credit: New Age MD


text:
Natural private label skin care facial spray. Natural Makeup Setting Spray- MUST HAVE
Makeup artist must-have, Cult-favorite! Give your skin that dewy radiance and glow.
Revitalize skin with amazing radiance. Whether spritzed for a hydrating on an instant or mid-day pick-me-up, this top of the line facial spray helps revive dehydrated skin anytime. This revitalizing mist infused with Rose Flower Water (Rosa Damascena) and Aloe Vera that help soothe and re-energize skin.
Used by top make up artists to give the skin that dewy finish. You can spritz on your makeup brush or sponge before blending in foundation or concealer. And again mist your face as a final step to add that glow.
Contains: 1- Organic Aloe Vera Leaf Juice 2- Rose Flower Water (Damask Rose)
No formaldehyde added No petroleum No parabens NO synthetic fragrances NO parfum NO artificial colors Wheat Fee Nut free Sulfate free Phthalate-Free
You can change the bottle, prices may change.
Regular price


text:
I made this bracelet last night while M and I watched Torchwood and Terminator: The Sarah Connor Chronicles. And as usual the sun has only made an appearance after I took the pictures. We are off on our trip to San Francisco and Idaho tomorrow, well down to H's favourite hotel and flying out on Monday. Thank god we aren't flying with BA this time, though M says he wants to have a look around the new terminal 5.
We will be back at the end of the month, the day before my birthday, so my present will be jet lag! Thank you all for reading my blog, if I get the chance I will update while we are away, so check back from time to time. And of course I will post lots of pictures when we return.
San Francisco here we come.
And Idaho too.


text:
The UBC Continuing Studies Centre for Intercultural Communication offers customized programs for international executives who wish to advance their skills to work effectively with North American counterparts. Offered in partnership with UBC Faculties, these programs link international executives with experts at UBC and in the Vancouver community in areas such as health, education, business and intercultural communication.
Faculties and Schools
- College For Interdisciplinary Studies
- Continuing Studies
- Faculty of Applied Science
- Faculty of Arts
- Faculty of Dentistry
- Faculty of Education
Faculty of Forestry
Forestry Collaborations in Asia
- Scholarship Ceremony - United Enterprise Benefits Group
- 2+2 Transfer Program for Chinese Undergraduate Students
- Research Partnership in Climate Change and Sustainable Forest Management
- International Partnership for Forestry Education (IPFE)
- Capacity Building with the Indian Forest Service
- Education Collaboration
- Research Collaborations
- Cooperation Programs under Development
- Introduction to UBC Forestry (Chinese/中文)
- Programs (Chinese/中文)
- Departments (Chinese/中文)
- School Resources (Chinese/中文)
- Entry Requirements (Chinese/中文)
- Forestry Collaborations in Asia
- Faculty of Graduate Studies
- Faculty of Land and Food Systems
- Peter A. Allard School of Law
- Faculty of Medicine
- Faculty of Pharmaceutical Sciences
- Faculty of Science
- Sauder School of Business


text:
So we have 8 days before court, I say "we" not because there are other people living inside my head, there's only enough room for me in there :~) I say we, because 1000's of lives of dogs, cats, a few ferrets, pigs, horses, chicken snakes, spiders, rats, & the occasional wildlife is all depending on the outcome (NO pressure there). Last year alone I rescued, or transported well over 1500 animals, this year far less, only a couple hundred or so. I also learned that: Yes, a 400lb stray pig can fit in a Toyota Corolla if they are willing to jump in & it can not outrun a 5 point buck with an attitude on a mountain trail, but you can fit 32 dogs of various sizes in it as long as you don't have to go to the bathroom for a 2 state duration, thank God it wasn't southern California, I also learned that it won't run out of gas until I roll into the shelter parking lot, then I'm on my own.
If I lose thousands of animals will die in the next 2 years, which I am sure would make the City Of Everett Prosecutor Mike Fisher, Shelter Manger Shannon Delgado, Animal Control Officer Lori Trask, City of Everett Attorney James Iles, the City's Mayor Ray Stephanson VERY HAPPY. See this is about ego's to them, they don't care about life, it's all about getting the one up. Evidently I brought a pickle to a gun fight. They won't care about all of these innocent souls who will die but they know I will so that will be the greatest pleasure for them, just like mutilating, beating & torturing my dogs was. So thinking that I may lose I have figured out the bright side of all of it, I have NOTHING to do for the next TWO YEARS but crawl up their butts for 24 months, then there is also my Tort Claim & my Appeal. My Tort Claim still stands even if I lose based on Constitutional law, if it was only Municipal, or State my chances would be slim. So what happens then is the Mayor approves another couple million dollars to fight me, they are almost at the Million dollar mark for a misdemeanor so what another 6 million or more? The taxpayers/voters have elected him, & they are letting him take care of their money so he can use it any way his ego sees fit, evidently the Troy Meade case didn't give them a clue how far he was willing to go to spend their money. The Everett Herald reports numbers around 1 million dollars the truth is it is about 6 or 7 million dollars (possibly more) after all is said & done & it is still ongoing. Now that I have itemized the costs with my big mouth now if ANYONE actually cares to investigate it I will sure they will find more. Oh & the way I found out is a retired Judge broke all of the court costs down to me, he should know.
Now it is said that most of these cases don't go to court, so that is how they justify the costs, but I am taking this to a jury trial. I will be televising the court proceedings whether by audio or video, so that you can see what happens when Judge David Mitchell is willing to ignore constitutional & state laws, when he should've dismissed it months ago, but you know: I talked back to him so now I have to pay… I figure I have already had to pay with the blood of my animals, & the abuse they have suffered for almost 11 months, & bet he'll be the happiest man on the earth if I lose & he gets to pronounce me guilty. He will also impose the MAXIMUM sentence, you know: To teach me a lesson, about not laying down & having my civil rights violated. Bad defendant!!!
That is the BOTTOM LINE here: How dare I challenge them, they are far superior to me, they are untouchable, everyone does what they say… Or else!
Now if I win… I have no idea what is left of my animals, emotionally or physically or who is even still alive. They have had to stall out on giving them to me since they have various outbreaks, been given poison meds, gotten parasitic infections, fleas, tapeworms, possibly been attacked or hit by a car, & you have to ask yourself WHY would anyone donate to Everett Animal Rescue Foundation if they knew what horrendous care they DIDN'T take of animals entrusted to their care, which doesn't surprise me considering the extent of the damage & injuries to the animals I was rescuing from there in 2009. I wish to GOD I wouldn't have listened to the other rescuers & had went public with this then & maybe by now something would've changed for the poor animals that are abused there on a daily basis judging from what I seen & experienced. (Remember it's not slander or libel when you have WRITTEN documentation)
I would like to invite anyone who feels like coming to the trial so you can see & hear for yourselves, how your tax dollars are being wasted. It is at the Everett Municipal Court, at 8:30 a.m. on November 3rd & November 4th 2011. If you are not able to make it then I will be televising it like I said before, either by audio or video. I've got someone setting it up for me so you will be able to go to specific parts & to create a search index for it as well. Since someone already took the liberty of sending me a list of all the volunteers for the shelter, & family members as well as any friends or family to the City Govt so we won't get a rigged jury. It is truly amazing to me how many people hate the Government in Everett. It is also very humbling to see how many people stand behind me & how many agencies that have invited me to come & live in their jurisdiction so I can continue to save animals & contribute to their communities, or even how many elected officials & other govt employees have pitched in to help me understand the process & what to do to fight. My entire appeal will be paid for in full if I lose because of the kindness of attorney's who are aware of this as well from as far as New York who are willing to help & put in man & research hours to assist state's attorneys.
All I want is to feel my babies in my arms again, all I need is to see their beautiful faces, to be able to lay my precious baby George to rest & free his soul so that someday he may return to me, but I am fighting evil & this world is the Devil's domain as evidenced by the actions of the City players in this drama, but in the end Good always triumphs over Evil.


text:
Want your brands to stand out?
We take cleaning personally
Cleaning is a personal business. Brand innovations should be personal too. Regional, cultural, economic, and environmental factors can affect what you clean, how you clean, when you clean, and who does the cleaning. We take all of this into account to help your brand become the chosen one.
Cleaning with a conscience
The world needs a serious clean-up. Our solutions provide sustainable answers to some of the world's biggest problems – like water shortage, pollution and excessive chemical use. A low-temperature detergent is not just what's right for your business or your consumers – it's also the right thing to do.
Different consumers, different insights
Jacob loves leisure - not laundry
As a modern New Yorker, Jacob's life is filled with work, music, sports, and advocacy. For him, laundry should be done quickly and efficiently to allow more time for life in the fast lane.
What does Jacob look for in a detergent?
• Quick-cleaning action to get the job done.
• Deep cleaning of dirt and stains from city life and leisure
• High performance at a low temperature for his sustainable lifestyle
Susan goes the extra mile...or three
In Kenya, Susan walks three miles each day to get laundry water for her family, who need clothes that look clean and bright.
What does she look for in a detergent?
• A hand-wash solution
• Effective cleaning with minimal water use
• A solution that is gentle on her hands
• Great-looking results
Juanita's fast life demands fast laundry
Time is money for Juanita. The ambitious Brazilian needs a fast and effective cleaning solution to accomodate her busy schedule.
What does she look for in a detergent?
• Gentle on fabric, tough on stains
• Effective cleaning that makes faded colors come to life
• A consistently clean, bright appearance
• Cleaning that removes fuzzing and pilling
Mei fights dust and dirt
Every day, Mei and her children battle the crowds, pollution and humidity of Shanghai. Mei wants a detergent that gets rid of urban battle scars – like the stains from sebum, dirt and dust.
What does she look for in a detergent?
• Effective cleaning for sebum and dust soils
• Suitability for indoor drying in humid conditions
• Natural and safe cleaning
Mikako is hands-on at work and at home
Mikako is one of many successful single working women in Tokyo who cares about her career and her home. She has an automatic dishwasher, but she washes pots and pans by hand.
What does she look for in a dishwash?
• Gentle on hands and cookware
• Tough on dirt and grime
• Minimal soaking and scrubbing time
Lakshmi makes every drop count
Like many people in Mumbai, Lakshmi sticks to a strict laundry routine. She has a washing machine, but prefers to wash most of her clothes by hand. Lakshmi has access to water for only a few hours each day – so she needs to make every drop count.
What does she look for in a detergent?
• A hand-wash detergent
• Effective cleaning with minimal water use
• Gentle on hands and skin
• Fast cleaning action - before the water runs out
Whites stay white. Colors stay bright.
Hit the right note with your consumers
The Novozymes Medley® multi-enzyme solution is the perfect composition for any stain. You just need to press play.
Each enzyme in this unique multi-enzyme blend is there for a specific reason - to target each stain and meet every need. For you and your brand, this means:
Flexibility: Medley® is available for liquids, powders and hand-wash detergents.
Consistent and outstanding performance: In-depth cleaning, time after time
An enzyme to remove all kinds of stains: Targeted stain-relevant action
Simplifies procurement and production processes: A one-order product that enables higher processing control
Spot-on stain removal
Even the best detergents are challenged by stains. There are several kinds, they are difficult to remove, and they often require cleaning that is dependent on stain and fabric type.
Our stain-removal enzymes are designed to target specific stains in the most effective, sustainable, and efficient way possible.
Types of stain-removal enzymes:
- Protease for protein stain removal
- Amylase for starch stain removal
- Lipase for grease stain removal
- Mannanase for mannan-based stain removal
- Pectin-degrading enzymes for fruit-based stain removal
Benefits of stain-removal enzymes:
- Provide targeted stain removal – match the right stain with the right enzyme
- Remove stubborn stains like meat, pasta, and lipstick
- Create unique brand claims
- Allow for more sustainable laundry detergents via biodegradable enzymes.
What's all the fuzz about?
Fuzz and pills on fabric can ruin an entire garment. They make new clothes look old, bright colors look jaded, and smooth fabric turn rough.
How do you create a detergent formulation that gets rid of them? You guessed it - Novozymes' enzymes.
The fuzz and pill removal power of enzymes
- Keeps fabric, especially cotton, looking new by cleaving protruding fibers
- Removes fuzz and pills from diverse fabric types
- Keeps fabric surface smooth and soft
- Keeps garments looking new
- Retains color brightness and prevents fading
- Creates unique laundry brand claims
- Allows for more sustainable laundry detergents via biodegradable enzymes
Because there's no such thing as snow-whitish
Not whitish. Not used-to-be-white. Just pure, crisp white. That's a brand claim that will make any detergent stand out – and it's exactly what we offer detergents with our laundry detergent enzymes.
Regular washing damages cotton fibers, resulting in bristly microfibrils trapping dirt and preventing whites from staying white. Regular bleaching agents aren't the solution. They can't prevent soil deposition or particulate soiling of fabrics. But enzymes can help your detergent live up to its promise of lasting whiteness.
Whiteness-retention benefits of enzymes
- Perform better than bleaching agents for whiteness retention
- Retain whiteness of clothes
- Keep clothes looking new
- Stop fabric graying by preventing soil deposition on clothes
- Make laundry detergents more sustainable via biodegradable enzymes
Dishrupt the status quo
Give consumers a helping hand
Soaking, scrubbing and hand-washing dishes is a time-consuming process for anyone. Our sustainable enzymatic hand dishwash solutions are designed to promote easier living through easier cleaning.
Our enzymatic solutions target complex food stains for a consistent and efficient clean. They also reduce the need for soaking and scrubbing by 50% compared to traditional non-enzymatic detergents. That's more time to enjoy life – and less time spent at the sink.
Set life to easy mode
Consumers buy dishwashers to save the time spent washing dishes by hand. Unfortunately, they are often trading in one set of problems for another. Dishwashers can cause cloudy glassware and a build-up of starch and protein on dishes.
The solution? Our range of sustainable, enzymatic automatic dishwash solutions.
Our enzymes break down starch and protein soils on dishes – reaching places the dishwasher's water jets don't. This means effective soil removal, no build-up and an environmentally-friendly solution.
Now, automatic dishwashing will stand for less effort and better cleaning.
Clean like a pro
Food and
Don't re-wash. Re-think.
Professional fabric care is a competitive industry with high consumer expectations. It's important to tackle the growing list of consumer needs. Novozymes Leviti® can do that.
- Cleaning becomes fast, easy and more efficient as enzymes break down the tough stains and facilitate easy cleaning
- Flexible format compatible with liquid detergents and liquid boosters
- Lower re-wash rates
- Increased textile lifetime
- The cost-effective choice - it does away with needless rewashing
- The sustainable choice – more enzymes mean fewer chemicals and more mild washing conditions
High-level cleaning
Novozymes offers a full range of enzymes that act on food residues for cleaning in place (CIP) at food and beverage processing plants.
- Improved cleaning
- Extended equipment lifetime
- Environmentally-friendly cleaning products
Microorganisms at your service
Microorganisms are efficient and fast at removing dirt caught in drains, in grease interceptors, and in fissures on hard surfaces.
Novozymes delivers sustainable cleaning solutions that are ready to go further than other cleaning agents. The hard-working microorganisms make it easier to clean hard surfaces properly, and they efficiently break down fats and other substances trapped in drains and grease interceptors.
- Fast cleaning and a longer-lasting effect
- Reduced malodor by breaking down odor molecules
- Environmentally-friendly cleaning products
A healthy clean
Enzymes are active ingredients for cleaning in the healthcare industry. They efficiently level up cleaning performance against high alkalinity to secure a consistent reprocessing of an instrument before it gets disinfected.
- Superior cleaning performance
- More gentle on sensitive instruments like endoscopes
- Effectiveness at mild pH levels and under low-temperature conditions
- Boron-free
- Biodegradable
Stench warfare
Fight the stink with microorganisms. Our effective microbial solutions degrade the odorous molecules and organics found on hard surfaces and fabrics.
- Effective neutralization and removal of a wide range of malodors
- Long-lasting, in-depth odor control through degradation of odorous molecules and odor-causing organics
- Advanced microbial technology for powerful, long-lasting odor control
- Sustainable, natural cleaning products
This party has a dress code – green
We all have a favorite color. At Novozymes, it's green. Our products and services allow consumers to clean with a conscience, and our sustainable manufacturing practices feature improved water efficiency, energy savings, and reduced waste and carbon footprint.
Ready to join the party?
Go green with us
- Strengthen your brand and increase your sustainability profile
- Differentiate your products to increase your market share in current and new market space
- Own new brand claims based on third-party certifications
- Get on the fast track to a certified, environmentally-preferred cleaning product line
- Benefit from transparent, science-based proof of environmental compliance
The benefits of enzymes
Coming Clean
The use of enzymes in household detergents results in lower washing temperatures, reduced water consumption, reduced washing times, and a reduced load of toxic substances in waste water (enzymes replace chemical substances in detergents).
- European Commission, Joint Research Centre
Coming Clean
Enzymes have enabled detergents to work better at removing stains, offering whiteness and brighter colours, as well as fabric care and wear benefits. Enzyme containing detergents are effective with smaller dosages (detergent compaction) and perform well under a broad range of conditions including washing at low temperatures such as 30°C.
- A.I.S.E. (International Association for Soaps, Detergents and Maintenance Products)
Coming Clean
53% of North American consumers soak their dishes before washing them in a dishwasher because they do not trust the efficacy of their dishwash detergents.
- Novozymes ADW consumer survey, January 2016
Coming Clean
From a cleaning performance as well as a sustainability point of view, enzymes are highly desirable ingoing substances of detergents. Enzymes enable improved cleaning at lower temperatures. They are renewable and readily biodegradable substances. Enzymes can substitute or reduce some of the oil and mineral based detergent ingoing substances such as surfactants and phosphates.
- European Ecolabel


text:
National Security Adviser John Bolton will warn the Iranian regime that there will be "hell to pay" if they "continue to lie, cheat and deceive" or "cross" the U.S. and its allies, according to excerpts of the speech he's set to give later this afternoon.
Why it matters: Bolton's speech, in which he'll also declare the Iran deal "the worst diplomatic debacle in American history," contains some of the most aggressive and confrontational language we've seen from a U.S. administration in recent decades. Bolton has argued for military intervention in Iran in the past, and he warns in this speech: "We are watching, and we will come after you."


text:
Patrick J. Mahoney studied cultural history at NUI Galway's Centre for Irish Studies, and now teaches in the department of history at Sacred Heart University, Connecticut. He is interested in the study of emigrant narratives, and the Irish historical experience as it relates to those in the United States and Britain. This column highlights the stories of significant people and places with West Cork connections, throughout the world.
The drab, grey sky hung like a morose fog over the hustle and bustle of New York City, reflecting the mood of the day below. The usually upbeat, rhythmic ebb and flow of midtown Manhattan appeared more sluggish than any other normal day in the concrete jungle. However, this was not just any other day. This was the scene a few weeks back, in the immediate aftermath of Donald Trump's stunning victory in the recent United States Presidential Election. In years past, the city might have been jubilant following the victory of one of its most well-known native sons, whose high-style and business savvy often made him a quintessential figure in the metropolis's depiction in pop culture. However, the days of 'The Donald' reflecting New York's image and values have long since passed.
On the day in question, my girlfriend and I found ourselves traversing the gloomy city streets, trying to enjoy the many sites while avoiding the mix of angst, disappointment, and uncertainty that had undoubtedly enveloped the majority of those that we encountered. After grabbing dinner a few blocks from Rockefeller Plaza, it seemed like the mood had lifted. The Christmas lights, though perhaps a bit too early for the season in fairness, were out in abundance. The accompanying festive garland and bows decorated many of the storefronts, and one would nearly expect to see shades of Shane MacGowan and Kirsty MacColl, God rest her, harmonically arguing away, singing about a 'fairytale' in these very same urban environs.
However, far from the waxing sounds of the Pogues' holiday classic, we were met with the words of a very different tune on our stroll back to Penn Station: "Donald Trump, not OK, racist, sexist, anti-gay!" These, and a number of other like-messages were the ditties chanted by hundreds of protestors, mostly young students, who had taken to the streets in thronging waves to voice their frustration at the values espoused by the new President-elect over the previous months. Their destination lay uptown, at the lavish, emblematic Trump Tower.
We stood for a while, gawking at the spectacle and remarking about what was truly a historical moment, before continuing on to catch our train. However, after observing Trump's recent cabinet appointments in the past few weeks, and chatting about both the protest and the nature of the impending Trump presidency with Cormac Ó hEadhra on Ráidío na Gaeltachta, I began to revisit the scenes of that evening, and think back upon the nature of the many issues that had driven such a diverse group to take to the streets of not only New York, but all of the major cities across the breadth and width of the country.
Donald Trump became a pop culture phenomenon in the United States as the host the 'The Apprentice', a show in which aspiring moguls competed for his approval. Each episode ended with Trump dramatically telling one low-performing contestant, "You're fired". Now that Trump has been 'hired', what kind of country will he lead, and how will he lead it? His popular support stemmed mostly from Americans who wanted a change from the status quo. Some are driven by a belief in limited government, others by a desire for conservative morality, economic reform, or tougher polices on immigration and terrorism. Meanwhile, opponents challenge these positions, and argue that strong policing in the name of immigration and terrorism will also severely curtail the rights of native-born non-white Americans in the name of safety. As reports of neo-Nazi meetings, swastika-laden graffiti and verbal and physical attacks on everyone from women to immigrants pour in day by day from around the country, I sit here wondering what this means moving forward.
In a recent sit-down interview with the New York Times and on the television programme '60 Minutes', Trump was challenged to comment upon such claims, and in particular, the despicable acts carried out by some supporters in the name of his campaign. In the latter interview, seated atop a gold, throne-like chair amidst the other members of his family, the President-elect noted, "I am saddened to hear that". He then looked directly into the camera, making a stern plea to anyone engaged in such intimidation to "stop it". But is this message too little too late? Trump couldn't really be that out of touch with the reality of the situation, could he? He's not a clueless guy. In fact, he is quite clever. Therefore, there is no way that while out on the campaign trail in recent months, the billionaire businessman turned politician could have been unaware that his rhetoric had been fueling intimidation and attacks upon immigrants, minorities, and Muslims. Seen in this light, Trump's order to "stop it" seems more like a calling off of the dogs, or an acknowledgement that, "it's OK. The fight is over, we won." However, assuming for a moment that his plea was genuine, this presents a larger issue. The fact that such acts have continued, and in some cases heightened, even after Trump has so clearly distanced himself from some of the more sensational elements of his campaign rhetoric, indicates that he has perhaps opened a Pandora's box with regard to race relations amongst subsections of the population in America. Unfortunately, such cannot be stopped now by simply issuing a command on network television, as might have worked on his previous gig.
Further criticism has come from those who claim that Trump's election may threaten the rights of those Americans whose lifestyles seem dangerous to the conservative Christian values of some of Trump's closest allies, including vice president-elect Mike Pence. Pence's outspoken views on homosexuality, which in the past have included the proposed diversion of public funds to provide 'conversion therapy', appeared to be amongst the central motivations of many of those that we saw marching on the night of the protest in Manhattan. This has remained a popular talking point. In light of last year's marriage referendum, it was such views held by Pence that recently drew the ire of the public after Enda Kenny, following a conversation with the former Indiana governor, tweeted that he "certainly knows Ireland and the issues that matter to our people."
For his part, Trump has stated in the past week that he will not challenge the legality of gay marriage, and will not seek to prosecute his former opponent, Hilary Clinton. The distance between his campaign rhetoric and the reality of his administration remains unknown, but tellingly, those protestors who took to the streets the night of his election continue to march. What's driving their steps might be Trump's selection of controversial figures to serve on his staff and in his cabinet. Steve Bannon, editor of a far-right newspaper known to publish anti-Semitic, misogynistic, and racist views, will serve as Trump's chief of staff. Jeff Sessions, a Senator from Alabama, whose 1986 nomination for federal judgeship was rejected because of racially charged comments and actions, will serve as his Attorney General. However, perhaps most concerning is Trump's appointment of Myron Ebell, a noted skeptic of climate change, as the head of the Environmental Protection Agency. Such an appointment falls in line with Trump's noted desire to dismantle many of the environmental policies put in place by the previous administration.
Ultimately, Trump will have many campaign promises to keep to his supporters, and fears to allay among his opponents. A Trump presidency will likely continue to inspire controversy, and will present an (at least four year) answer to a question posed by 'The Apprentice' itself. What happens after you're hired?


text:
Premal Shah, president of Kiva.org recently gave a detailed interview to Techcrunch on the peer lending portals plans for the next five years. In the interview, Premal Shah surprisingly reveals that he considers the social gaming website Zynga his biggest competitors.
"I think our biggest competitor is actually, probably Zynga. It's not other nonprofits it's actually competing for people's attention. That fantasy football player in Canton, Ohio who might play two hours of Farmville at night, how do we get them to think about Uganda?…If building a real farm on Kiva can be as compelling as building a virtual farm on Facebook, then I think we've done our jobs really well."
Kiva.org is an organization that allows people to lend money through the Internet to microfinance institutions in developing countries all around the world. As of September 19, 2010, Kiva has distributed more than US$ 160 Million in loans from 757,183 lenders. The average loan size on Kiva is $382.77(Rs 16,000 approximately). Kiva currently enjoys a repayment rate of 98.90%.
Watch the Interview in the video below.
Read the entire Interview with Premal Shah of Kiva on Tech Crunch
About Premal Shah
Premal Shah is the co-founder of Kiva along with Matt Flannery.Premal Shah worked at PayPal for nearly 6 years. He is considered to be a part of the PayPal Mafia – a group of PayPal alumni who have gone on to found or co-found other successful companies, including YouTube, LinkedIn, Tesla Motors and Yelp.
Premal Shah has had a long standing interest in development and microfinance. In 1997, he was awarded a grant from Stanford University to research at one of India's then largest microfinance institutions, the Self Employed Women's Association(SEWA). More recently Premal co-founded the Silicon Valley Microfinance Network and spent 2 months working an Indian NGO focused on women's economic empowerment. Premal has graduated with a B.A. in Economics from Stanford University.


text:
Mental health activists, workfare campaigners and therapists protest against work cure therapy for benefit claimants with mental health disabilities
It's time for the psy professional bodies to stop colluding with the DWP Join the protest against the professional bodies supporting work cure therapy for benefit claimants with mental health … Continue reading
MHRN Open Letter on Streatham Jobcentre protest 26th June: coercive CBT to get welfare claimants "back to work"
Open letter from the Mental Health Resistance Network firstname.lastname@example.com MARCH ON STREATHAM JOB CENTRE – FRIDAY 26TH JUNE, 1.30 pm MEETING POINT: STREATHAM MEMORIAL GARDENS, STREATHAM HIGH ROAD/ STREATHAM … Continue reading
Facing psychological coercion and manipulation has become a daily part of claiming benefits
Felicity Callard, Durham University and Robert Stearn, Birkbeck, University of London Curing unemployment is a growth market for psychologists. Job Centres are becoming medical centres, claimants are becoming patients, and … Continue reading
Turn illness into weapon: Mental distress from a Socialist perspective Bruce Scott
This article was written as a response (partly) to an article that came to my attention that was posted on the Common Space website[1] concerning "mental health"[2]. It is laudable … Continue reading
Happiness and the capture of subjectivity
The Happiness Movement and the capture of subjectivity I am a kind of paranoiac in reverse. I suspect people of plotting to make me happy. ~ J.D. Salinger In … Continue reading
The sorry state of NHS provision of psychological therapy.
Healthcare Today carried the following headline at the end of January – "Figures from the Health and Social Care Information Centre (HSCIC) show fewer than 6% of referrals made under … Continue reading


text:
[Power of Expression] Stimulating your desire to create something new.
1/30sec, F2.8, ISO200, EV-1, WB:AUTO,
With use of GW-2, no trimming
Further improvements for features that prevent overexposure and underexposure.
Ricoh's image processing technology and pixel interpolation algorithms are used to control overexposure. By comparing pixel outputs and then predicting and interpolating image data in the overexposed area, the dynamic range has been expanded by as much as +1 EV. We have also added a new Dynamic Range Compensation feature that serves to expand dynamic range. It improves the richness and smoothness of gradations for everything from highlights to dark sections.
This is a new feature added to the GR DIGITAL IV. It suppresses overexposure and underexposure by automatically dividing up the image and performing Contrast Correction on each area. It is also useful when it comes to moving subjects like animals and in handheld photography because the corrections can be done with a single shot. The user can select from Weak, Medium, and Strong.
This feature allows you to take a series of two images with different exposures and combine the parts of each that are properly exposed. It can produce a brightness that is close to what you see with the naked eye in everything from light areas to dark areas, even for backlit scenes where the range between light and dark is considerable. You can choose from Weak, Medium, and Strong.
- *When shooting with dynamic range double shot, please be sure to use a tripod. Subjects that are moving cannot be photographed clearly.
- * The way the effect appears will differ depending on conditions.
Enhanced auto-bracket functions
In addition to the existing settings for exposure and white balance, the camera now includes settings for Contrast Bracket and Dynamic Range Compensation Bracket as well as an Image Setting Bracket feature that allows you to record a sequence of three shots with two image settings of your choice. This eliminates the need to bother with changing photo settings manually. You can continue to take photographs with comfort, just concentrating on the subject.
A new scene mode for capturing star trails against a landscape.
In addition to Dynamic Range, Skew Correction, and Movie,
Interval Composite mode has been added to the list of scene modes.
6sec, F2.8, ISO100, EV±0, WB:MANUAL, 262shots, no trimming
Take a series of photos of the night sky at a fixed interval. The camera selects and combines only the high-intensity pixel data from each of those images. This is very effective for when you want to combine the trails of the stars and the moon with a landscape. You can also save copies of the images separately before combining them.
Featuring two new modes. Enhanced image setting modes
1/800sec, F8, ISO100, EV-0.3
WB:AUTO, High Contrast B&W, no trimming
1/20sec, F6.3, ISO200, EV-0.3
WB:AUTO, Bleach Bypass, no trimming
Two new modes have been added to Image Settings*. The first is Positive Film, which will recall a famous type of film used in the past. The second is Bleach Bypass, with which you can create low chroma, high contrast silvered images. The camera also has standard settings such as High Contrast B & W which gives images the flavor of dramatic monochrome prints and Cross Process for creating unique color combinations. You can apply these image settings regardless of the exposure control mode in use. The breadth of your creations will expand.
- * Vivid, Standard, B & W, B & W (TE), Setting 1/Setting 2, High Contrast B & W, Cross Process, Positive Film, Bleach Bypass
Multiple Exposure Shooting, making composite photographs easy and fun
1/5sec, F4, ISO100, EV-1.0, WB:AUTO,
Multiple Exposure, no trimming
A new feature with this model is the ability to combine up to 5 photos. Have fun getting creative with your photos by creating drama through combining shots of different scenes into a single image. You can adjust the settings in detail as necessary, such as automatically adjusting the amount of exposure in accordance with the number of snaps, saving each image separately before combining, and saving images when combining. You can also use the Retake shot option immediately after you take a photo, allowing you to get the photo you imaged with ease.
Now even bulb shooting is available with Exposure control modes
The exposure control modes are Auto, P (program shift), A (aperture priority), M (manual exposure), and S (shutter priority). Maximum set exposure speed is 1/2000 of a second. With the GR DIGITAL IV, it is now also possible to set B (bulb) and T (time) for M mode,* giving you more freedom in making your exposure settings. When set to B, exposure continues while the shutter-release button is pressed. When set to T, exposure begins and ends when the shutter-release button is pressed.
- * Can also be operated using cable switch CA-2 (optional).
- * The time can be set for a maximum length of 180 seconds.
High-quality macro mode, for minimizing field curvature
Minimum shooting distance of approximately 1 cm. You can photograph an approximately 26 × 19 mm area to fill the screen. When using Macro Mode, some of the lens groups that do not move during normal focusing move to a specific position for near-distance photography. This is an original, image quality priority feature that corrects field curvature during near-distance photography. In Macro Mode, thanks to improvements in the algorithm, the autofocusing speed has been cut by up to half compared to the GR DIGITAL III. Focusing is more pleasant than ever.
Choose the best finish by yourself. Free image settings and level corrections
The range for making adjustments to contrast, sharpness, and so forth for each image setting has been increased (to 9 steps). This allows you more freedom than ever in creating your works. In Playback mode, Level Compensation enables adjusting the brightness and contrast of the photos you have taken in the camera itself. Use Auto to leave it up to the camera to make minute adjustments. By setting it to Manual, you can work with a histogram to adjust the brightness and contrast immediately and freely.
Fastidious when it comes to the uses of light: A small and sophisticated internal flash
The internal flash is a manually operated pop-up type. The dimming range is approximately 20 cm to 3.0 m (ISO Auto). It has a full range of modes, including Auto, Flash Synchro., and Manual Flash. You can also adjust the shade and shadow balance more finely using Flash Compensation (-2.0 to +2.0 EV) and Manual Flash (12 steps, from Full to 1/64). For the synchronization timing, you can choose either the normal [1st Curtain] setting or the [2nd Curtain] setting that can render the light traces of moving objects naturally.
Four-mode Aspect Ratio settings allow choosing what you want to express
1/500sec, F4, ISO100, EV-0.7, WB:AUTO, no trimming
Now a 16:9 aspect ratio is available in addition to the existing 4:3, 3:2, and 1:1 settings. This is useful for giving a photo an expression with a sense of width. Using this, you can also display and enjoy photos with a ratio matched to the screen when playing them back on high-definition-capable computer screens and televisions.
- Top |
- Features |
- Externals |
- Specifications |
- Function-enhancing firmware |
- Option |
- Sample Images


text:
In this tutorial I will explain the process of setting up the Image Slider on the Home page.
In order for Image Slider to appear on the Home page correctly we will need to verify that "Front page displays latest post". Navigate to WordPress dashboard -> Settings -> Reading and see if "Front page displays" is set to "Your latest posts".
In the next step we will need to create "Featured Posts" that will act as image sliders. Go to WordPress dashboard -> Post -> Add New and create new posts.
- Add a title in the Title entry box.
- Add your post's content in the Content box.
- Add featured image. To insert featured image to the post please refer to this article: http://codex.wordpress.org/Post_Thumbnails
Please refer to the Writing Posts article.
Put "Featured Posts" that we created in the separate category ( for example lets create new category "Slideshow" and associate featured posts with it ).
Navigate to WordPress Dashboard -> Appearance -> Theme Options -> Home Page and set "Display Featured Image Slider" to "ON". Select category "Slideshow" in the drop-down box for "Select Featured Posts Category".
Go to WordPress Dashboard -> Appearance -> Theme Options -> Image Slider to configure additional settings.
That's it!


text:
(APOE Cys130Arg)
Short summary
This is generally known as the ApoE4 allele of ApoE and is associated with increased risk of Alzheimer's. 20-25% of individuals are heterozygous for this variant, and 1-2% are homozygous. Data from Khachaturian et al. suggests an average 7% of all individuals developed Alzheimer's by the age of 80; when this is split by ApoE4 status: 10% of ApoE4 heterozygotes (3% increased attributable risk), 40% of ApoE4 homozygotes (33% increased attributable risk), and 5% of non-carriers (2% decreased attributable risk). Notably, their model suggests 70-75% of people would eventually develop Alzheimer's by the age of 100 regardless of ApoE4 genotype (and 25-30% are resistant, regardless of genotype), but that ApoE4 variants shift the disease onset to occur significantly earlier (4 years earlier for heterozygous carriers, 13 years for homozygotes).
Other variants in this gene are associated with Alzheimer's, but Polyphen 2 & SIFT predict nonpathogenic
Compared to E2 & E3, ApoE4 has lower rate of delaying plaque formation in transgenic mice & triggers more amyloid-beta production
See 11950276, He X et al. 2007 (17428983).
Very high significance findings in many studies
See Farrer LA et al. 1997 (9343467), Khachaturian AS et al. 2004 (15123497).
Alzheimer's disease
Treatment is largely palliative; there is research seeking treatments for the disease or prevention of it but no conclusively effective treatments have been found so far.
3% increased attributable risk for Alzheimer's by age 80 for heterozygotes, 33% increased attributable risk for homozygotes.
See Khachaturian AS et al. 2004 (15123497).
High clinical importance, pathogenic
(The "high clinical importance, " qualifier is assigned automatically based on the above evidence and importance scores.)
Inheritance pattern
Summary of published research, and additional commentary
Other sources & evaluations covering ApoE4: (1) ApoE on OMIM (this variant is listed rs429358 and CYS112ARG due to alternative amino acid numbering) http://www.omim.org/entry/107741 (2) Alzheimer's Disease on 23andMe: https://www.23andme.com/health/alzheimers/techreport/ (3) GeneReviews Alzheimer Disease Overview: http://www.ncbi.nlm.nih.gov/books/NBK1161/
Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH,
Pericak-Vance MA, Risch N, van Duijn CM. Effects of age, sex, and ethnicity on
the association between apolipoprotein E genotype and Alzheimer disease. A
meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA. 1997
Oct 22-29;278(16):1349-56. PubMed PMID: 9343467.
This paper is the one typically cited regarding the effects of ApoE E2 and E4 on the risk of Alzheimer's disease. Because translating odds ratios to attributable risks is complicated (requiring assumptions regarding allele frequencies and disease frequencies) and because Khachaturian et al. was able to follow a particularly long-lived population, data from Khachaturian et al. is what is used by GET-Evidence for estimating the effect of ApoE4 on Alzheimer's risk.
The document has moved here.
ApoE4 delayed plaque formation in transgenic mice the least, in three ApoE variants (E2 > E3 > E4) tested in a mouse model of Alzheimer's.
Khachaturian AS, Corcoran CD, Mayer LS, Zandi PP, Breitner JC; Cache County
Study Investigators. Apolipoprotein E epsilon4 count affects age at onset of
Alzheimer disease, but not lifetime susceptibility: The Cache County Study. Arch
Gen Psychiatry. 2004 May;61(5):518-24. PubMed PMID: 15123497.
The population analyzed in this study notably contains some very old individuals, allowing the authors to carefully study the lifetime influence of ApoE4 on Alzheimer's disease. They find that, in general, Alzheimer's disease is best described by a model where a fraction of the population is resistant to the disease and will never develop it no longer how long they live. In this model, 25-30% of individuals appear to be in this "resistant" group.
When individuals are segregated according to ApoE4 carrier status (homozygous, heterozygous, and non-carrier), they find that the age of onset is shifted earlier for carriers of ApoE4 (Figure 3). For non-carriers, ~50% are diagnosed with Alzheimer's disease by the age of ~95 years. This shifts to ~91 years of age for individuals heterozygous for ApoE4 (~4 years earlier onset) and ~82 years for ApoE4 homozygotes (~13 years earlier onset).
Investigating the incidence of Alzheimer's by age 80 in their model, 7% of all individuals on average have developed it by this age (Figure 2). Non-carriers have an average rate of ~5%, heterozygotes a rate of ~10% (2x), and homozygotes a rate of ~40% (8x) (from Figure 3). Penetrance in GET-Evidence is evaluated according to these numbers, with 3% increased attributable risk for heterozygotes (from 7%) and 33% increased attributable risk for homozygotes.
He X, Cooley K, Chung CH, Dashti N, Tang J. Apolipoprotein receptor 2 and X11
alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor
protein and beta-secretase, leading to amyloid-beta production. J Neurosci. 2007
Apr 11;27(15):4052-60. PubMed PMID: 17428983.
Functional Evidence (variant shows increased risk of production of Abeta in neuroblastoma cells)
hu025CEA - CGI sample GS01669-DNA_D02 from PGP sample 27316983
het C @ chr19:45411941
hu241DEA - CGI sample GS01175-DNA_D05 from PGP sample 1205491
het C @ chr19:45411941
hu2D6140 - CGI sample GS01173-DNA_F06 from PGP sample 64191565
het C @ chr19:45411941
hu38168C - CGI sample GS01173-DNA_H06 from PGP sample 91708424
hom C @ chr19:45411941
hu3CAB43 - CGI sample GS01175-DNA_D03 from PGP sample 27486199
het C @ chr19:45411941
hu4040B8 - CGI sample GS01175-DNA_D01 from PGP sample 31286272
het C @ chr19:45411941
hu44DCFF - CGI sample GS01669-DNA_C07 from PGP sample 74521372
het C @ chr19:45411941
huA0E089 - CGI sample GS01175-DNA_B04 from PGP sample 88590671
het C @ chr19:45411941
huA90CE6 - PGP16 (huA90CE6) build 37, from CGI var (software ver 22.214.171.124), CGI sample GS000006909
het C @ chr19:45411941
huCA017E - CGI sample GS01175-DNA_B01 from PGP sample 86206034
het C @ chr19:45411941
huFAF983 - CGI sample GS01175-DNA_F02 from PGP sample 95788191
hom C @ chr19:45411941
GS18502 - var-GS18502-1100-36-ASM
het C @ chr19:50103781
GS18504 - var-GS18504-1100-36-ASM
hom C @ chr19:50103781
GS18517 - var-GS18517-1100-36-ASM
het C @ chr19:50103781
GS19129 - var-GS19129-1100-36-ASM
het C @ chr19:50103781
GS21767 - var-GS21767-1100-36-ASM
het C @ chr19:50103781


text:
Jobs and opportunities
We are always on the lookout for talented and highly skilled people to make a positive difference towards the work we do with girls and young women.
The Juliette Low Seminar Grow your leadership skills and meet fellow Guides and Scouts from around the world. Join us at #JLS2019. Volunteer at a WAGGGS World Centre Take the opportunity of a lifetime and spend time volunteering at one of our five World Centres! Volunteer resource pool Join the WAGGGS volunteer resource pool and support Guiding and Girl Scouting all over the world


text:
Red Bull
Flugtag 2017
Miley and the Wrecking Balls
Team Members
Jason Waynick
Web Webster
Jerry Jordan
Scott Naylor
Miley and the Wrecking Balls
About us
Miley and the Wrecking Balls is a middle-aged, all-male team, who are co-workers at Griffin Technology in Nashville, TN. We are pretty darn excited for Sept 23rd because this is an opportunity to show our bravery and engineering expertise and go swimming, near naked, in the Cumberland River without getting hassled by the cops.
We're building our Survivor Soar in our very own state-of-the-art development lab at our office. Why will the Survivor Soar fly the farthest? Well, it's being designed by someone who actually has aeronautics experience. Oh, and our pilot is a mere wisp of a man.
We have an actor, an Australian, a metalworker, a world traveler, an engineer, and a product developer on our team. We're quite the bunch. If everything above doesn't convince you to come cheer for us on Sept 23rd here are three more words for you:


text:
Cuiabá rentals, vacation homes direct from the owners
You will find many studios, apartments, houses and villas for your vacations in Cuiabá. Contact the owners directly on the IHA site and enjoy the best rental rates, promotions and last minute deals that meet your budget. Visit the photo gallery on private rentals for a break with family or friends. All vacation listings on IHA are verified, plan your trip to Cuiabá with absolute confidence!
8 bedrooms House for rent for > 30 people
$600 Night
Breakfast included
direct by owners
from $600/Night*
See the rates
3 requests already received
Advert 7505
Show map
Pantanal Backpacker Hostel Traditional accommodation in a private property. swimming pool, city, sky scraper, fantastic sunset viewHouse Rental in Cuiabá #7505 >Swimming poolDirect access to the beach
Interior facilities
- 8 Bathroom
- 10 Shower room
- Living room 650 Sq.ft.
- Shared kitchen facilities
- Dining room
- Tv den
- City vacation
- Ideal for all age groups and conference
- Setting : Urban, Pleasant
- Bus stop / bus station at <165'
- Culture
View the advert


text:
6 Day Top End
$1,755per person
Explore the rich Aboriginal history and rugged natural beauty of the Northern Territory.
This 6 Day Top End self-drive tour takes you from Darwin to Katherine along Nature's Way.
Call us on to talk to one of our Australia Experts
Tour Inclusions
The following are included in your package tour:
Price Excludes: International and domestic flights to Australia, airport taxes, meals.
Conditions: Prices are per person, twin/double-share and subject to availability. Prices are correct at the time of submission (Aug18) but are subject to change without notice. Valid for travel 1 Aug 18 to 31 Mar 19. Advertised price is based on travel in October 2018. Blackout periods, surcharges or discounts may apply when traveling outside of October 2018. Car hire excess fee of AU$550 applies. This will be imprinted on a credit card upon collecting the vehicle. Excess reduction options are available at an additional cost per day. Car parking fees may apply in some locations. Please enquire for more information.
Click here for our full terms and conditions.
Day 1: Darwin
Day 2: Darwin to Kakadu, 250km
Day 3: Kakadu
Day 4: Kakadu to Katherine, 300km
Day 5: Katherine to Darwin, 320km
Day 6: Litchfield National Park or Tiwi Islands day trip