text: NYSE:NR - Newpark Resources Stock Price, Forecast & News Adding Choose a watchlist: Adding You have already added five stocks to your watchlist. Upgrade to MarketBeat Daily Premium to add more stocks to your watchlist. Adding Newpark Resources Inc Please log in to your account or sign up in order to add this asset to your watchlist. Log In and Add $5.21 -0.02 (-0.38 %) (As of 01/29/2020 03:14 AM ET) Add Compare Today's Range$5.13Now: $5.21▼$5.3450-Day Range$5.10MA: $5.79▼$6.3552-Week Range$4.97Now: $5.21▼$9.68Volume352,981 shsAverage Volume804,856 shsMarket Capitalization$467.41 millionP/E Ratio34.73Dividend YieldN/ABeta1.54 ProfileAnalyst RatingsAdvanced ChartEarningsFinancialsInsider TradesInstitutional OwnershipHeadlinesOptions ChainSEC FilingsSocial Media Share on FacebookShare on TwitterShare on LinkedInShare on RedditShare on StocktwitsPrint this articleShare by Email Newpark Resources, Inc provides products, rentals, and services primarily to the oil and natural gas exploration and production industry. It operates through two segments, Fluids Systems, and Mats and Integrated Services. The Fluids Systems segment offers drilling and completion fluids solutions, and technical services to customers in the North America, Europe, the Middle East, Africa, Latin America, and the Asia Pacific regions. Read More… Industry, Sector and Symbol Stock Exchange NYSE Industry Oil & gas field machinery Sub-IndustryOil & Gas Equipment & Services SectorOils/Energy Current SymbolNYSE:NR Previous Symbol CUSIP65171850 CIK71829 Webhttp://www.newpark.com/ Phone281-362-6800Debt Debt-to-Equity Ratio0.32 Current Ratio3.89 Quick Ratio2.44Price-To-Earnings Trailing P/E Ratio34.73 Forward P/E Ratio65.13 P/E GrowthN/A Sales & Book Value Annual Sales$946.55 million Price / Sales0.49 Cash Flow$1.01 per share Price / Cash Flow5.16 Book Value$6.27 per share Price / Book0.83Profitability EPS (Most Recent Fiscal Year)$0.41 Net Income$32.28 million Net Margins1.68% Return on Equity3.50% Return on Assets2.15%Miscellaneous Employees2,500 Outstanding Shares89,714,000Market Cap$467.41 million Next Earnings Date2/6/2020 (Confirmed) OptionableOptionable Receive NR News and Ratings via Email Sign-up to receive the latest news and ratings for NR and its competitors with MarketBeat's FREE daily newsletter. NR Rates by TradingView Newpark Resources (NYSE:NR) Frequently Asked Questions What is Newpark Resources' stock symbol? Newpark Resources trades on the New York Stock Exchange (NYSE) under the ticker symbol "NR." How were Newpark Resources' earnings last quarter? Newpark Resources Inc (NYSE:NR) issued its quarterly earnings results on Wednesday, October, 30th. The oil and gas company reported ($0.02) EPS for the quarter, missing the Thomson Reuters' consensus estimate of $0.07 by $0.09. The oil and gas company earned $202.76 million during the quarter, compared to analysts' expectations of $221.38 million. Newpark Resources had a net margin of 1.68% and a return on equity of 3.50%. The firm's revenue was down 13.8% compared to the same quarter last year. During the same quarter last year, the company posted $0.04 EPS. View Newpark Resources' Earnings History. When is Newpark Resources' next earnings date? Newpark Resources is scheduled to release their next quarterly earnings announcement on Thursday, February 6th 2020. View Earnings Estimates for Newpark Resources. How can I listen to Newpark Resources' earnings call? Newpark Resources will be holding an earnings conference call on Thursday, February 6th at 12:00 AM Eastern. Interested parties can register for or listen to the call using this link or dial in at Not Available. What price target have analysts set for NR? 2 analysts have issued 1-year price targets for Newpark Resources' shares. Their forecasts range from $9.00 to $13.00. On average, they anticipate Newpark Resources' share price to reach $11.00 in the next year. This suggests a possible upside of 111.1% from the stock's current price. View Analyst Price Targets for Newpark Resources. What is the consensus analysts' recommendation for Newpark Resources? 2 Wall Street analysts have issued "buy," "hold," and "sell" ratings for Newpark Resources in the last year. There are currently 2 buy ratings for the stock, resulting in a consensus recommendation of "Buy." View Analyst Ratings for Newpark Resources. Has Newpark Resources been receiving favorable news coverage? Press coverage about NR stock has trended somewhat negative this week, according to InfoTrie Sentiment Analysis. The research group scores the sentiment of news coverage by monitoring more than six thousand news and blog sources in real time. The firm ranks coverage of public companies on a scale of negative five to five, with scores closest to five being the most favorable. Newpark Resources earned a news sentiment score of -1.0 on InfoTrie's scale. They also assigned news articles about the oil and gas company a news buzz of 10.0 out of 10, meaning that recent news coverage is extremely likely to have an effect on the stock's share price in the next several days. View News Stories for Newpark Resources. Who are some of Newpark Resources' key competitors? Some companies that are related to Newpark Resources include Schlumberger (SLB), Halliburton (HAL), National-Oilwell Varco (NOV), TechnipFMC (FTI), Dril-Quip (DRQ), Oceaneering International (OII), Helix Energy Solutions Group (HLX), RPC (RES), Seacor (CKH), Oil States International (OIS), Tidewater (TDW), Matrix Service (MTRX), Era Group (ERA), Geospace Technologies (GEOS) and TETRA Technologies (TTI). What other stocks do shareholders of Newpark Resources own? Based on aggregate information from My MarketBeat watchlists, some companies that other Newpark Resources investors own include Endologix (ELGX), Chipotle Mexican Grill (CMG), Aegean Marine Petroleum Network (ANW), Apache (APA), Ritter Pharmaceuticals (RTTR), Charles Schwab (SCHW), Hudson Technologies (HDSN), Vicor (VICR), Zoetis (ZTS) and Primo Water (PRMW). Who are Newpark Resources' key executives? Newpark Resources' management team includes the folowing people: Mr. Paul L. Howes, Pres, CEO & Exec. Director (Age 63)Mr. Gregg S. Piontek, Sr. VP & CFO (Age 48)Mr. Edward Chipman Earle, VP, Gen. Counsel, Chief Admin. Officer, Chief Compliance Officer & Sec. (Age 46)Mr. Bruce C. Smith, Exec. VP & Pres of Fluids Systems (Age 67)Mr. Matthew S. Lanigan, VP and Pres of the Mats & Integrated Services (Age 48) Who are Newpark Resources' major shareholders? Newpark Resources' stock is owned by a number of of retail and institutional investors. Top institutional investors include Boston Trust Walden Corp (1.14%), Dalton Greiner Hartman Maher & Co. (0.78%), California Public Employees Retirement System (0.38%), SG Americas Securities LLC (0.22%), Arizona State Retirement System (0.07%) and Assenagon Asset Management S.A. (0.06%). Company insiders that own Newpark Resources stock include Bruce Campbell Smith, David C Anderson, Douglas L White, Gregg Piontek, John C Minge, Mark J Airola, Matthew Lanigan and Paul L Howes. View Institutional Ownership Trends for Newpark Resources. Which major investors are selling Newpark Resources stock? NR stock was sold by a variety of institutional investors in the last quarter, including Arizona State Retirement System, Boston Trust Walden Corp and Louisiana State Employees Retirement System. Company insiders that have sold Newpark Resources company stock in the last year include Douglas L White and Paul L Howes. View Insider Buying and Selling for Newpark Resources. Which major investors are buying Newpark Resources stock? NR stock was acquired by a variety of institutional investors in the last quarter, including California Public Employees Retirement System, Dalton Greiner Hartman Maher & Co., Assenagon Asset Management S.A. and SG Americas Securities LLC. Company insiders that have bought Newpark Resources stock in the last two years include John C Minge and Paul L Howes. View Insider Buying and Selling for Newpark Resources. How do I buy shares of Newpark Resources? Shares of NR can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Vanguard Brokerage Services, TD Ameritrade, E*TRADE, Robinhood, Fidelity and Charles Schwab. What is Newpark Resources' stock price today? One share of NR stock can currently be purchased for approximately $5.21. How big of a company is Newpark Resources? Newpark Resources has a market capitalization of $467.41 million and generates $946.55 million in revenue each year. The oil and gas company earns $32.28 million in net income (profit) each year or $0.41 on an earnings per share basis. Newpark Resources employs 2,500 workers across the globe.View Additional Information About Newpark Resources. What is Newpark Resources' official website? The official website for Newpark Resources is http://www.newpark.com/. How can I contact Newpark Resources? Newpark Resources' mailing address is 9320 LAKESIDE BOULEVARD SUITE 100, THE WOODLANDS TX, 77381. The oil and gas company can be reached via phone at 281-362-6800 or via email at [email protected] MarketBeat Community Rating for Newpark Resources (NYSE NR)Community Ranking: 2.4 out of 5 ( )Outperform Votes: 284 (Vote Outperform)Underperform Votes: 314 (Vote Underperform)Total Votes: 598MarketBeat's community ratings are surveys of what our community members think about Newpark Resources and other stocks. Vote "Outperform" if you believe NR will outperform the S&P 500 over the long term. Vote "Underperform" if you believe NR will underperform the S&P 500 over the long term. You may vote once every thirty days. This page was last updated on 1/29/2020 by MarketBeat.com StaffFeatured Article: What does RSI mean?


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"What do you do for a living?" It's a question that often comes up in conversation—around the dinner table, at networking events, or even on the sidelines of a weekend soccer game. And if you work in the PR industry, you'll know more than anyone, that question isn't always so easy to answer.
"Our role [as PR professionals] has greatly evolved," says Rachel Thexton in a recentHuffington Post article entitled "PR? What's that again?" Sure, our objectives to help connect our clients to their target audience, and help them develop content that creates positive engagement with the public haven't changed; it's how we do it that's constantly in flux.
"The tools, strategies, and skill sets for the job have changed," says Rachel, explaining that this has created a new breed: the hybrid PR professional. "While identifying news stories, writing media materials, and media relations are still important skills, the 2013 edition of the PR pro also needs to have a working knowledge of social media and other online platforms, along with the ability to create content that resonates with the online community."
Hashtags, blog influencers, and social media platforms are game changers that can't be ignored. They could be the difference between running a successful campaign and loosing key business.
Rachel also points out that Vancouver's increasing diversity provides opportunities for PR pros to distinguish themselves by considering the languages and culture of their audiences. Working with team members who have the language skills to reach out to key influencers in these communities will help your messages spread even further.
With so much change in the tools we use to do our jobs, Rachel suggests focussing on bringing things back to fundamentals of our craft.
"Bring listening back to the centre of PR, versus the old school marketing mantra of pushing out messages. Online communities expect a two-way dialogue," she says. She also suggests revisiting your storytelling skills, personalizing pitches, and spending time cultivating relationships with media and bloggers.
And lastly, don't be boring. "The new hybrid PR professional must be more interesting, more timely, and faster than ever before to stay ahead of the ever-changing mobile media world."
Is your role as a PR profressional changing in Vancouver?
Get more of Rachel Thexton's take on the PR industry by following her on Twitter at @rthexton.

subset: commoncrawl


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Come Exercise Your Pet In Our Dog Gym!
Unable to exercise your pet due to adverse weather conditions? Going on vacation and want your dog to have extra play time or one-on-one training? Our Dog Gym is your answer. Be able to play fetch, work on obedience or just walk your dog year round.
The following rules help to ensure all utilizing our Dog Gym are safe and our program runs smoothly:
Rate for 30 minutes in the Gym
Rent the gym for you and your friends
Rates for Supervised Gym Time
One-on-one gym play time with a staff member is available for kennel, daycare and grooming dogs
Training Classes, Parties and Group Activities
Please contact the individual trainer or activity coordinator for information, fees and requirements


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Status: Closed
Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
11 Wks - All Body Systems Working, 18 Days - Heart Begins to Beat, 5-9 Days - Sex CAN Be Determined, 6 Wks - Brain Waves CAN Be Detected, 8 Wks - All Body Systems Present, 8 Wks - Baby Begins to Suck Thumb
Be the first MLive.com user to add photos or videos of Right To Life - Livingston County Inc
We are a nonpartisan,nonsectarian,nonprofit organization of diverse and caring people united to peacefully protect the precious gift of human life from fertilization to natural death.


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Virtual Library
Start Your Search
H. Brahmbhatt
Author of
P1.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 206)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Advanced Diseases - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
P1.01-072 - Targeted Delivery of a Synthetic microRNA-Based Mimic to Treat Thoracic Cancers (ID 2911)
09:30 - 17:00 | Author(s): H. Brahmbhatt
- Abstract
- Slides
MicroRNA expression is commonly suppressed in cancer, contributing to tumor cell biology. Recently we demonstrated that multiple members of the miR-15/16 family are downregulated and have tumor suppressor functions in malignant pleural mesothelioma (MPM), an asbestos-related cancer for which few treatments are available. These results are similar to previous findings in non-small cell lung cancer (NSCLC). As multiple microRNAs from the same family are downregulated in MPM, we investigated whether a single synthetic mimic based on the consensus sequence of the entire family could restore activity of the entire family.
Novel microRNA mimics based on the consensus sequence of the miR-15/107 group were designed (con15/107.1 to 4). The effects on growth, migration, target regulation, drug sensitivity and angiogenesis of the con15/107 mimics were compared with native miR-15 and miR-16 mimics using standard assays in MPM and lung cancer cell lines in vitro. The regulation of specific target genes was assessed by RT-qPCR, Western blot and luciferase reporter assays. Global gene regulation was assessed by proteomics. Activity of con15/107 mimics was investigated in vivo in xenograft models in nude mice.
The consensus mimics inhibited growth and migration of MPM and lung cancer cell lines in vitro, and effects were greater than with native miR-15 or miR-16 mimics. Growth inhibition was associated with an induction of apoptosis, and downregulation of predicted targets of the mimics. Target gene interactions were confirmed with 3'UTR reporter constructs, and proteomics identified a number of candidate genes involved in consensus mimic-induced growth inhibition. Consensus mimics also sensitized multiple MPM and lung cancer cell lines to chemotherapy agents, and inhibited angiogenic activity in endothelial cells. In a xenograft model, the consensus mimic con15/107.2, packaged in bacterially-derived, EGFR antibody-targeted, EDV[TM]nanocells, inhibited MPM tumor growth in vivo.
The novel con15/107 mimics based on the consensus sequence of the miR-15/107 group have greater activity than native miR-15 or miR-16 mimics in vitro and are active in vivo. Increased activity correlates to greater target gene downregulation. These preclinical studies support a Phase I clinical trial has been initiated for patients with MPM or NSCLC failing standard therapy. This represents the first trial of microRNA replacement as a therapy for thoracic cancer.
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Essay from exhibition catalogue:
Lush, Plush, and Slush – The Painted Forms of Sarah Munro
Andrew Paul Wood
Sarah Munro's work is all about association-chains of temptation plucked out of the "real-world-visual-soup". The gleaming idol; the red-headed whore in Toulose-Lautrec's Paris, the shiny red proverbial apple with which the Serpent tempted Eve, and Eve in turn tempted Adam – the notion of beauty is permanently enmeshed in temptation. Visual pleasure retains the taint of lust, covetousness or parochial self-interest cloaked in a cheeky swagger, but Munro is less about that sort of hunger. There is none of the '80s post-structuralism deceptiveness that "context" is the same thing as "meaning". These suave, but straightforward and not duplicitous shapes shy away from facile readings. They are succulent, architectonic hieroglyphs that fanfare their 'is'-ness in a primal tribute to art-historical past and technological future, playing to globalised free market economics. Munro cherishes aesthetically pleasing material effects and flirts directly to our basest aesthetic instincts with her strangely arbitrary shapes; like the Monolith in 2001: A Space Odyssey, they inscrutably keep their secrets.
Munro's aphoristically minimalist biomorphic sculptural forms – sleek fibreglass shapes with lustrously glossy surfaces saturated in bold-yet-diaphanous colours that seem sampled from the more expensive lipsticks and nail polish, designer house paint or luxury sports cars, bridging the gap between minimalism and pop art. These sculptures with their CAD modeled lines suggest industrial production, but no function or purpose. Marcel Duchamp thought that any manufactured object could be art, and Andy Warhol suspected art's elitist status was unwarranted. Munro likewise considers painting an object not to be privileged over a car, or lipstick – they are all simply slick, coloured surfaces to be ogled, consumed and appreciated.
The artist's appreciation of the skills and abilities of others is an important part of her practice; Munro operates in the spirit of the Bauhütten. Here that utopian spirit of cooperation is translated to something more akin to a surfboard manufacturer: hand-laid and hand-finished applications of fibreglass and resin over blocks of foam. Despite the dependence on cutting edge design and manufacturing technologies in Munro's work, the 'collaborative' artistic process under one master's name is a product of the Renaissance studio.
The subtly gradated colour, reminiscent of the difficult taffeta effects favoured by Mannerist painter Pontormo and rediscovered in the ambiguous colour fields of Mark Rothko and Edward Ruscha, is sprayed on in layers, then coated with more layers of high gloss and laboriously hand polished. It is undercoated and prepared in much the same traditional process as a canvas, panel or fresco, but at the same time reminiscent of the kind of craftsmanship that goes into preparing the bodywork on a Ferrari – my favourite being the 599 GTB Fiorano: the car is first painted silver for luminous reflectivity, over which are applied no less than six coats of fiery-hot-sex-scarlet-woman-bloodlust-cherry-popping-lady-in-red is applied. This is finally topped off with a layer of bubblegum pink lacquer for immaculately glossy shine. The cumulative effect says "HOT SEX", which is exactly the message the marketing department is trying to sell.
With silhouettes like supersonically aerodynamic injection-moulded plastic Henry Moore and Barbara Hepworth, Munro's sculptures come in candy-coloured pastels, high-keyed dayglo-neon pop fluorescents and Las Vegas slinky-kinky tertiaries compressed by sinuous Coke bottle va-va-voom concave and convex curves like a tight dress on a loose woman, or the hard-edged lozenges of vampish, sharply faced costume jewellery. This is bling. The window of the viewer's attention is bombarded by the play of plum shading on harlot scarlet; fiery Jaffa orange against sunset blushing peach; lavender and ice-blue on azure; elegantly restrained grey and silver on white; acid apple-green; or opaque hotrod magenta and chocolate in a series of hedonistic, pulsating, retina-grabbing theatrics.
With both car and sculpture the clever contours can only be achieved with hours of grinding back, filling and smoothing. Although the works themselves are static forms, many movements and shifts occur the longer one spends in front of them. From one angle they could be Robert Smithson's geoforms, from another it could be bodywork from a 1985 Lamborghini Countach. The sleek curves and cunning shadowing set up Escher-esque optical illusions that morph and flex from concave to convex in polymorphous perversity before our eyes.


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This is the final Catchat for 2017 and on behalf of the Committee I wish all Members a Safe and Happy Xmas and New Year.
Our next Social meeting will be on the 23rd January 2018 with guest speaker Senior Constable Robert GRINTER (M 0413563667) from the South Australia Police Road Safety Centre. I've included Robert's mobile number if you have any questions 'on notice'.
We've had a great year for both short and long trips. Short trips have included destinations such as the Murray Mouth, Deep Creek, Ngarkat, Peake, Chowilla, Mystery drives, Angorichina Station. Polish Hill, Narcunda South. Copper Coast, Willunga, Mannum and Yankalilla. Long Trips have included the Victorian High Country, Limestone Coast, Buckleboo/Googs track, Simpson Desert and Cape York. The Training team have held successful events in the Peake Sand Dunes and the Morgan Quarry. These trips have enabled members to strengthen their 4wd skills whilst visiting some exotic locations in a spirit of friendship and camaraderie.
Planning for 2018 is well underway and whilst the AGM in March 2018 may seem quite distant, important decisions are already being made. Our Secretary Lee Nicolle and Treasurer Brian Cosh are stepping down and replacements are required.
For the health of the Club it's very important that we have members who are ready to take their turn and volunteer some time for the benefit of all and to enable ongoing succession planning. We still have a vacancy in the 'Environment' role.
In recent years the Committee has improved/expanded the activities offered eg. Mechanical Interest Group, Vehicle Familiarisation training and more 'day' trips for those members unable to attend trips with overnight stays. We need additional'behind the scenes' support for these important events within the Club.
Winter has seen many Committee members head off (making hay whilst the sun shines), placing undue strain on the remaining Committee. We are interested in talking to members who usually stay at home during this period – can you provide some short term assistance? The final option would be to close down many of our activities over winter – however this would cause significant and ongoing problems.
This is the time to step forward and offer whatever assistance you can to enable a smooth transition into another activity packed year.
I thank all Committee members (particularly Lee and Brian) for their contributions and look forward to many trips and adventures in 2018.
Des Leach


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A Democrat complains about Republican President Elect
"Goodbye free government, free elections, free speech, and free press, as well as all civil liberties." The election of 2016? No the 1876 election of Rutherford Hayes over Samuel Tildon.
Another famous Democrat Joseph Pulitzer – of Pulitzer Prize fame – called for 100,000 armed Tilden supporters to storm Washington D.C. Fortunately, it did not happen.
In 2016, nothing new.


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Having your chimney in your home can be very stimulating, and the truth is that nothing gives the room a warmer, cozier and more welcoming appearance than one of those stoves. In a way, people connect the chimneys with the heat of the "home" feeling and the comfort that the heat generated by combustion can provide. Investing in a good fireplace and a good quality can be a good option, but you will have to make sure you take into account all the aspects involved, so your choice will also help you reduce the heating costs of your home.
In general, chimneys can be a more economical solution to heat the house than other solutions there, but make sure that the right materials and parts have been used and that your house is "good" from the outside. Of course, you need to insulate your house properly, but sometimes some details move away from the owners when it comes to keeping the heat inside the house. For example, they forget the fact that their windows can allow a large amount of heat to leave the house and let in the cold, which eventually makes them pay much more than they need for heating.
Also, choosing chimneys that break the heat and keep it inside the burner is very important, and you must make sure you are investing not only in good looking boards but that it is also efficient to do so. By taking this type of choice, you can keep the heat inside your home for longer, reducing the need to put more fire records or use additional heating systems for your home.
Perhaps most importantly, consider investing in a taller chimneys fireplace. This part, which does not seem important because of its smoke, can make a difference when it comes to keeping the heat inside the house, but many chimney owners do not think much about it. However, the upper dam can be very important because it will "seal" the upper part of the chimney mainly, and cold air is not allowed to pass through the chimney to your home (making your heating efforts almost useless).
When buying a fireplace regulator for your fireplace, be sure to think about certain aspects. To begin with, it must be effective to keep the energy inside the chimney/burner/home. The highest price of the gate can reach the chimneys to a few hundred dollars, but you can find some very effective devices at a much lower cost. Also, make sure it comes in the right size for your smoke and make sure you also go with the fireplace cover (which is also necessary if you want to prevent snow, rain, and animals coming from the chimney). You can also find multiple styles that suit your home, so you can be sure that the shock absorbed will not spoil the aesthetics of your home as well.
Chimneys can be a great investment, but as a homeowner, you'll want to be very effective at keeping warm and looking good. When buying a fireplace regulator for your fireplace, be sure to think about certain aspects.


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Safari Boo characters go to school to spread joy and trick-or-treat fun to over 60 kids from the Movement for the Intellectually Disabled of Singapore (MINDS)
SINGAPORE, 1 October 2015 – Ahead of Children's Day, more than 60 kids from the Movement for the Intellectually Disabled of Singapore (MINDS) – Woodlands Gardens School were presented with an early trick-or-treat surprise in school this morning. Instead of the usual school assembly, the kids entered a hall splashed with colourful livery and a burst of prancing fairy tale characters from River Safari's Safari Boo.
Back for its second year after strong turnout in 2014, the merry-not-scary Safari Boo event will see River Safari transformed into a fantastical wonderland where kids will meet adorable fairy tale characters, go through a journey of wildlife discovery featuring trick-or-treat stations and enjoy two themed presentations, among other programmes.
Held on 23, 24, 25, 30, 31 Oct and 1 Nov, this year's fairy tale theme will feature a line-up of fantastical characters from Pinocchio to the Little Mermaid. Children aged 12 years and below enjoy free admission from 6pm. More information can be found on www.safariboo.sg


text: Welcome to Episode 6 of Potty Mouth Poopcast! In this episode we cover another taboo topic: Hairy pits and legs - Shaving vs Not shaving. We discuss our own opinions and practices in terms of body hair and we also delve into the social aspect and it's heavy influence in such practices. To Shave Or Not To Shave, That Is The Question.


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Here is my card for Sharon Johnson's ssnotime#38. Today's challenge is about stamping with a *Silhouette* image.
Of course I had to use my super gorgeous Stamp from *Hero Arts* called *Silhouette Corner*.
Actually this would have been a combined submission for Sharon's and Beate's Challenges until I have messed up....the image ended up to big for the WSC Sketch and I figured I just have to suck it up and make another card.....(hate when that happens - LOL)!!!
At least I had a Sketch already....I have started with a Whisper White card base. Then added the Wild Wasabi and Pumpkin Pie CS. I have adhered the cute DS Wild Wasabi Ribbon. Next I have started piercing along the top and bottom of the CS's.
The image was colored with Pumpkin Pie and my self made Wild Wasabi Blender Pen. The image was raised with Stampin Dimensionals before I have added it onto the card.
The sentiment is from the *All Holidays* Set and I have stamped it with Chocolate Chip and I also pierced right below the sentiment. ~TFL~
Make sure you check out my card below that I have made for Beate's WSC51. Don't want ya to miss it - LOL!!! Have a great weekend!!!


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Matter and energy are necessary aspects of living forms, but they do not fundamentally distinguish between living and inanimate systems. "Information" is, however, a basic characteristic of all sentient beings. This does not mean that life has now been explained, but a very important factor has been mentioned. Even at the lowest level, in the case of viroids, which are simpler than viruses, where we have single molecules of nucleic acid, information is the distinguishing entity. Without a doubt, the most complex information processing system is a human being. Even when applying the theorems mentioned initially, we can now formulate a further equation, L2, contrasting with L1:
Life = material part (physical and chemical aspects) + + non-material part (information having an intellectual source) (L2)
This formula comprises a radical extension over and against basic assumption E3 of evolution, but even L2 is not sufficient, because it cannot explain all life phenomena (as, for example, the shaping of bodily growth, consciousness, and responsibility). This author introduced three classes of information that are present in sentient organisms [in G7, p. 136–139]:
- Structural information: Although not sufficient for explaining the origin of an organism, genetic information is essential. It contains the individual constructional blueprint for every life-form, and ensures its effective transmission from generation to generation. In every grain of wheat, it is responsible for the growth of a new plant that in its turn produces wheat grains as seed. In the same way, the merging of male sperm cells and female ova determines the genetic combination of the new person. The embryo cannot develop without the accompanying constructional information. This specific information is decisive for the development of the appropriate structures, even if it is not sufficient. By using only a few similar building blocks (20 amino acids), the program determines whether an oak, a rose, a butterfly, a swallow, a horse, or a man is constructed. The most important part of transferring the genotype is not the essential material interest, but the information within, and this is non-material.
- Operational information: In all the different kinds of life-forms
there is an immense variety of information processing systems
that drive the internal "operational" processes:
- All the required operational and structural materials must be synthesized inside the cells. In the human body alone, fifty thousand different proteins have to be built up according to exact chemical and procedural requirements. If the specifications of only one of these proteins are absent from the controlling program, it could be dangerous or lethal (e.g., insulin).
- The nervous system serves as the communication network for all relevant information for controlling the harmonious operation of all organic systems, as well as for controlling the movements of the limbs.
- Hormones carry chemical messages for controlling certain growth processes and for the activation of numerous physiological functions.
- Communicative information: Communication, especially with
others of the same kind, plays a central role in the life of organisms.
For this purpose, systems for the transmission and
reception of signals exist which certainly comprise some of the
most amazing features of creation. In the animal kingdom,
communication systems essentially serve the following purposes:
sexual courtship (e.g., the mating calls of birds, and the
sexual secretions of insects), communicating a source of food
(bee dances), detection of enemies (the pheromones of ants),
the sharing of tasks among families or colonies (like ants and
bees), and for befriending other organisms (ants appease the
caterpillars of the butterfly "Blue" by allomones). The variety
and sensitivity of the various receptors are astounding. Some
quantitative examples:
- Certain grasshoppers can detect soil vibrations having an amplitude of only 5 · 10-10 cm. That is 1/25 of the diameter of the first electron orbit of a hydrogen atom.
- The threshold of audibility of the human ear is 10-12 watts per square meter. By this it reaches the physically possible limits.
- The heat-sensitive organ (pit organ) of the Malayan moccasin snake can detect a change in temperature of 1/1000°C, independent of the temperature of its own body.
- Even a single molecule of the pheromone bombykol secreted by the female bombyx mori can still be detected by the male's antenna. In this respect, one should remember that one cubic centimeter of air contains 26.9 · 1018 molecules (or nearly 27 million billion).
Human speech is distinctly different from all animal communication systems. Articulated speech is a very versatile instrument, which not only serves to convey meaning, but it is the foundation of all our thoughts and mental activities. The German language employs more than half a million words and it is impossible to calculate the number of possible combinations of the numerous forms of the words into sentences and paragraphs that our power of speech is capable of. The number of expressible thoughts is also exceedingly large. No animal communication system possesses such creative possibilities; they can only be used for strictly limited, "burned in" forms of expression.
Nearly all information processes are controlled by the brain. It is the most complex but also the least understood organ. Most biological functions cannot proceed without the brain. If the brain is dead, then the whole organism also dies (cerebral death; compare OB5).
All these information systems require an intellectual source according to the information theorems mentioned above. The endeavors of evolutionists to explain life as a purely mechanistic phenomenon gloss over these facts and ignore these verifiable theorems.


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Geek fiction
If I had to read this book back in 1998 when it was published I would have chucked it after the first few pages. Back then cryptology meant Aravind Swamy in Roja, NSA was something I hadn't heard about and 'computers' to me meant MS Word and MS Paint. But now I'm in that comfortable place where I am aware of NSA and their snooping, knowledgeable enough to understand bigbig computer terms and ignorant enough look beyond any technical inaccuracies in this book. Book snobs might look down upon Dan Brown and his readers but that's them. I like Dan Brown.
The plot : Someone has created the holy grail of encryption software or something and the NSA wants it. Because this means that everyone's secrets will be safe inside the Digital Fortress and the American government can't peek into people's
bathrooms emails all over the world. This miracle code thingy has put NSA's supersnooper computer TRANSLTR on a digital wild goose chase and it is unable to break it. Like in all Dan Brown thrillers here also you have the standard threesome: a boss, a beautiful woman with brains and a clueless professor dragged into something that doesn't concern him in any way. You also have the mandatory mysterious assassin with the odd name, a clock ticking away on a countdown and a puzzle that needs to be solved. Then there is the standard parallel good intentioned person(s) trying to figure out/ stop what the main three are up to. And of course a nailbiting chase that happens in a European country with some gruesome murders thrown in for extra flavour. Then the item, here it is a ring, that has an inscription or something that has to be solved to stop the digital apocalypse or something. And spoiler: The boss. Wait. Did I just join the book snob club?
The puzzles: North Dakota. Hello, we know that Dan Brown likes anagrams. I figured that out longlong before they did. The 'mystery' code in the ring was such an anticlimax. Hiroshima-Nagasaki. Uranium 235-238. Hello, that was so so obvious. I could have solved that five pages before they did.
But anyway. Typical or not, I enjoyed the book. A much needed quickie thriller. I've crossed out all the Dan Brown books off the list now. And I'm eagerly waiting for his next one.


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We are in dark times. I don't need to list the events of the last few months around the globe and in the UK. Theatre is what I love and know, and it's what I always hope will help change the world but like so many things that we invest ourselves in, it often lets us down.
On Friday morning I woke up, like about 180,000 others, in a muddy field after not enough sleep to find that Britain had voted to leave the European Union. I am going to make a demographic generalisation and suggest that if you are reading this you were also as shocked, upset and angry as I was. Facing three more days of Glastonbury Festival, how do you keep on partying when you realise that the opinions and values of opposing ideologies are factually becoming a majority and making irreversible, ill-informed change?
Like parts of our press, our friends and our social media sites, the Glastonbury Festival is a political bubble – overwhelmingly pro-Remain. It's a haven for the values of freedom of expression, of creativity, of peace, of inclusion, of ethical trading, of environmental awareness, of sustainability, of doing things because they are fun and worthwhile and make people happy, of people doing things because they love and care about them, and though obviously a multi-million pound business it is still resisting the extremes of capitalism. It's in this space that I woke up on the morning after the referendum.
Liveness and shared experience have for a long time been hugely more important factors in my interest in theatre and performance than narrative or traditional craft. I go to see a lot of both live theatre and music. I don't go to the theatre because I want to see the best acting on stage, and I don't go to gigs because I want to hear an album performed exactly like it is on CD. The best gigs are when the band goes all out, turns up the volume, breaks it down, ramps up the fury, puts on a show, and when the audience is part of the experience. Everyone knows that if you want to be in the action for a gig, you go front and centre for the mosh-pit or the pre-teen fangirling and there's the self-selecting system where you choose how close you want to be to the action and how 'into' the gig you're going to get that night by where you stand. Standing is active, and it's also half way to dancing or jumping and so far from sitting, that extra knee bend from being passive and individual to being part of something with everyone else. There is nowhere to sit down at a muddy Glastonbury.
We want to express ourselves and mark ourselves out, but we want to feel together and know that we aren't alone, to know that other people think and feel like us. It's sometimes only when everyone else is dancing that we can dance and sometimes only when everyone else is singing that we can sing: doing it together makes us feel liberated and stronger, that we're part of something greater than us, united, and we lose our inhibitions.
Anthropologist Victor Turner called this 'communitas', and I am going to quote from Wikipedia here as I am very far from being an anthropologist: an "unstructured state in which all members of a community are equal allowing them to share a common experience, usually through a rite of passage. Communitas is characteristic of people experiencing liminality together." 'Liminality' being the "quality of ambiguity or disorientation that occurs in the middle stage of rituals". Theatre, music, clubbing all having ritualistic qualities.
I often feel united in an experience with an audience in the theatre, but sometimes that audience is just 50 or 200, maybe 600 people sat in the dark. Rarely in the UK do we present theatrical events that can rally enough numbers or take place in the right spaces to create the feeling of 'communitas' that we need at the moment to feel like we are not alone and we can make the change for a better country and world. It can only happen outdoors: public space has always been political, and now that it's ever-increasingly becoming corporatized, it is even more so.
The infrastructure we have in this country that is making and presenting really exciting, contemporary, radical, politicised theatre and performance that I think has the power to inspire change are the smaller spaces, or perhaps a biennial festival in a larger space. It's partly down to the economics of a ticket buying public but it responds to a culture that has prioritised a few hundred years of dull, intellectualised, conventional theatrical experiences and lost its political power and its audience numbers by doing so.
There is refuge on a dancefloor and there is anonymity in a crowd on a field, there is understanding in an audience. The atrocity in Orlando recently is made worse than simply the death toll because it took place in a safe space, the dancefloor of a club for the LGBTQ community. So many marginalised communities will tell you how dancefloors and streets are important creative and socio-cultural spaces. Partying becomes political because other artistic spaces have let us down. Unfortunately at the moment, it feels like the majority who believe in freedom, peace and a better future is newly becoming a marginalised, powerless group, but this doesn't have to be the case.
The famous Shangri-La debauched late-night area at Glastonbury aims to "holds a mirror up to the masses, challenging people in politics and play" through a mixture of clubbing, bands, performance art, installations, visual art and simply offering unconventional experiences. It's that combination of hedonism through art and music that at the moment feels especially pertinent to me, as our culture becomes sanitised. We've lost some important rare spaces that serve that grimy border: notably The Arches, Glasgow (RIP), The Shunt Lounge (RIP), The Royal Vauxhall Tavern (home to Duckie, amongst other legendary queer artists and events) is currently under threat again from developers, at Cambridge Junction (where I work) clubs have been reduced for various reasons, though it's good to see places like The Yard Theatre starting up nights.
But it doesn't have to be this way. I want to experience theatre that you can't walk by because the beat's drawn you in and you want to be part of it. I want to be at theatre that attracts numbers that make the authorities scared. I want to feel that I am part of the theatre; that it's been made for us in the audience not for the people on stage, and that it's welcoming as well as intellectually rigorous and formally experimental. We need to make the case for the arts and these things happening makes the case for themselves.
In my memory, all the biggest performative public art events that the UK have seen have been from French companies and I don't think it's a coincidence that they have a significantly healthier audience base, societal value for the arts and funding system. Artichoke brought Royal De Lux's The Sultan's Elephant to London in 2006 and La Machine's The Spider to Liverpool in 2008; Crying Out Loud brought Le Studio de Cirque's Place des Anges to London in 2012 as part of Piccadilly Circus Circus (I was part of the producing team) and it's coming back in July to Hull as part of the City of Culture celebrations. Free tickets for the show in Hull first crashed the website and then when relaunched 10,000 tickets sold out in 51 minutes, showing there is real thirst for events like these. These events feel special not just because they are spectacular, but because they take place outside, claiming the streets, and fill them with people who despite their differences are feeling part of something amazing, united and freer in the process. We want and need to be there.
In times like this, despite the logistical and financial challenges, I hope we can go bigger, more public and better with our theatre and our events. I wish it wasn't the case but in these deliberately and strategically divisive times, it feels like just being together is becoming radical.


text: West Highland Christian Academy Educating K through 12th grade Home About Us About Us Statement of Faith Quick Facts Staff Resources whcaFamily WHCA Family Calendar RenWeb (Parents) PTF Alumni Ways to Give FACTS Tuition Join Us Join Us Open House K4 Early Start Kindergarten Admissions Tuition Testimonials Dyslexia Academics Academics Curriculum Activities Homeschool Dyslexia Athletics Athletics Eligibility Contact Us WHCA Family > Calendar RenWeb (Parents) PTF > Fundraising Alumni > Ways to Give FACTS Tuition Parent Teacher Fellowship The Parent Teacher Fellowship is committed to supporting the ministry of West Highland Christian Academy. The goals are to encourage every parent to get involved, to support the faculty in both personal and professional ways, and to build community and school spirit. There is a place for everyone, regardless of employment status and time constraints. We want to help you find a place to get plugged in and participate. Our goal is to connect you with the opportunity that fits both your skills and your schedule. Every parent with a child at WHCA is automatically a member of our PTF. The PTF is a multi-faceted group that serves as a networking tool for our parents, a welcoming organization for new families, a social opportunity to connect our parents, teachers and students, and, most importantly, a vital piece of our children's overall experience. Without the support of the PTF, we would not be able to provide the level of benefits and activities that our families enjoy throughout the year. And the best news, you're already a member! The ultimate goal of all that the PTF does is to glorify the Lord and we believe that, "If anyone serves, he should do it with the strength that God provides, so that in all things God may be praised through Jesus Christ." I Peter 4:11 If you have any questions and/or would like to volunteer, please contact Kevin Whitted or Mary Wagner @ 248-887-6698 or by email at firstname.lastname@example.com


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Removing the plugin specified just meant that the error was reported for the next plugin.
Searching Google showed many discussions about this problem. Luckily the solution for me was easy enough - as described in this topic:
In <wordpress root>/wp-includes/cache.php I just added:


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Office employees 'too tired' to exercise
(HealthDay)—Barriers and enablers for good nutrition and physical activity influence employee health behaviors, according to research published online Sept. 12 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.
Krysten Blackford, of Curtin University in Perth, Australia, and colleagues conducted an online survey of 111 employees in 55 organizations to identify barriers and enablers for physical activity and nutrition and develop intervention strategies for health promotion in office settings.
The researchers found that the most common barriers to exercise and good nutrition among workers were fatigue and access to unhealthy food. Enjoyment of physical activity and knowledge of nutrition were enablers for good health behaviors.
"Many barriers highlighted the limited amount of time available to employees outside of working hours and the need to ensure healthy and supportive environments in the workplace," the authors write. "Intervention-strategy preferences demonstrated employee support for health promotion in the workplace."
Copyright © 2013 HealthDay. All rights reserved.


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Uppsala Ottoman Heritage
During its long history, Uppsala University has acquired extensive collections of a Turkish / Ottoman origin. An important part of the collection is manuscripts but there are also maps, paintings, watercolours, etc.
This material is of great international interest and the library has, with generous support from Republic of Turkey Promotion Fund, digitised a selection of the collection and published it in Alvin, Uppsala University Library's platform for digital collections and digitised cultural heritage: Uppsala Ottoman Heritage
The digitization was funded by Republic of Turkey Promotion Fund and carried out by Uppsala University Library in cooperation with the Turkish Embassy in Stockholm and the Department of Linguistics and Philology at Uppsala University.
E-mail: email@example.com
Phone: 018-471 39 00
twitter: @fragauub
Phone and chat available weekdays 9–18.


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Why don't I get exceptions when something unexpected happens in inbound scenarios in SAP Adapter?
You might have observed that in outbound scenarios, for example while calling an RFC, if something goes wrong, an exception is thrown to the user. This does not happen in the same manner for inbound scenarios, for example when receiving an RFC or an iDoc. Let us see what this difference is.
When an outbound call is made to SAP, the (simplified) scenario looks like this:
User code issues a request, and the response is sent by SAP. Any exceptions that occur in SAP or the adapter are propagated to the user. However, the inbound scenario looks like this:
The User code sends response to SAP's request. All exceptions are thrown to SAP except the ones that occur while the user code reads data – after all SAP is the party that issues the request in this case. This is the reason why we don't see exceptions when something goes wrong in inbound scenarios.
Now, is there a way to see the exceptions being passed to SAP?
Yes! Tracing is the answer. We recommend that you enable Error and Warning level tracing for adapters. The exceptions that are thrown to SAP are also traced and will find a place in the trace log if tracing is enabled. However, trace logs tend to grow huge – and picking out new entries manually can be daunting. Using the System.Diagnostics.EventLogTraceListner class instead of the XMLWriterTraceListener class, you can redirect your traces to the event viewer – the one stop solution to monitor your applications and services.
If you're working with the WCF service model, add the following to the configuration section of your app.config file. If you're working with Biztalk applications, add the following to the configuration section of your BizTalk configuration file, BTSNTvc.exe.config which is present under <system drive>:\Program Files\Microsoft BizTalk Server 2006:
<source name="Microsoft.ServiceModel.Channels" switchValue="Warning">
<add name="eventlog" />
<source name="Microsoft.Adapters.SAP" switchValue="Warning">
<add name="eventlog" />
<add name="eventlog" type="System.Diagnostics.EventLogTraceListener" initializeData="APPLICATION_NAME"/>
<trace autoflush="false" />
This will enable Warning level tracing (Errors + Warnings). Replace APPLICATION_NAME with the name of your application as you want it to appear in the event viewer. Now you can see the errors and warnings - even the ones that were thrown to SAP - in the event viewer. Neat!


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<myCurriculum type="pdf" ⁄>
Welcome back to lesson four in our Python from Scratch series. This tutorial will assume some prior knowledge of variables, data types, functions and print output. If you're not up to date, check out the previous three articles in the series to catch up.
Today, we're going to be delving into the subject of Object Oriented Programming (OOP). OOP is a very powerful way of organizing your code, and a solid understanding of the concepts behind it can really help you get the most out of your coding.
este é só um excerto do artigo, para aceder ao artigo completo, clique no link em baixo:
this is just a small excerpt from the article, to access the full article please click in the link below:


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Cameron Y. Brock is a Trusted Wrongful Death Attorney
As an avid motorcyclist, it should perhaps come as no surprise that Cameron Y. Brock is the motorcycle accident attorney Los Angeles has come to trust for personal injury cases involving vehicle collisions. In cases that involve motorcycle or auto accidents, Mr. Brock and his team at the Law Offices of Burg & Brock, Inc. are certain to look into issues such as road design, potential product defects, and the guilt and innocence of each prospective party.
For any motorcyclist, a top-ranked attorney is an absolute necessity. After all, at best, a motorcyclist is only protected by a safe helmet, leather apparel and a machine that is (hopefully) mechanically sound. That's why, in the event that the worst is to occur, a highly skilled head injury lawyer is an absolute necessity. At the Law Offices of Burg & Brock, Inc., you'll find a team that brings to the fore an impeccable track record of success, including a 98% success rate over the course of more than 5,000 cases.
Further still, they've earned over $100 million in awards and settlements for their clients, in cases ranging from product liability to slip and fall and even wrongful death. As a top wrongful death attorney, Mr. Brock and his team work to ensure the proper beneficiaries receive the extent of the damages due to them, as well as ascertaining the guilty party. In many cases, this serves as an essential aspect of the healing process, allowing grieving victims to go forward with their lives.


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Pituitary Function Tests
Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Pituitary Gland Disorders article more useful, or one of our other health articles.
Tests of the pituitary gland and pituitary function include:
Trending Articles
- Hormone levels: pituitary hormones are released in pulses and levels fluctuate during the day. A single blood test is usually insufficient to assess a pituitary hormone deficiency properly.
- Hormone stimulation tests: the precise protocols for the tests and the defined normal ranges vary between laboratories. Examples of protocols can be found by following the links in the 'Further reading & references', below.
- Visual field check: pituitary tumours may cause visual field defects.
- MRI or CT scan of the pituitary and surrounding structures.
Anterior pituitary hormone deficiencies[1, 2]
See also separate Hypopituitarism article.
A 'complete anterior pituitary function test' includes:
- Gonadotrophin-releasing hormone (GnRH) stimulation. GnRH is also known as luteinising-hormone-releasing hormone (LHRH).
- Thyrotrophin-releasing hormone (TRH) stimulation
- Insulin tolerance test (or alternative method of stimulating growth hormone and adrenocorticotropic hormone (ACTH) secretion).
Growth hormone
- Growth hormone levels are pulsatile and almost undetectable for most of the day and so growth hormone levels are measured by their response to stimulation.
- Low baseline measurements of insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), and insulin-like growth factor-binding protein 3 (IGFBP-3) suggest growth hormone deficiency. IGF-1 is most commonly measured.
- There are a number of different stimulation tests but the gold standard is insulin-induced hypoglycaemia, which is also used for cortisol deficiency. Alternative drugs used for stimulation include glucagon, clonidine, arginine and propranolol.
- Insulin tolerance test (also called insulin stress test):
- The insulin tolerance test is generally regarded as the best test to stimulate growth hormone and ACTH secretion as long as there are no contra-indications.
- Intravenous glucose may be required if severe hypoglycaemia occurs and an indwelling cannula should be inserted for the duration of the test.
- Contra-indications include age over 60 years, coronary heart disease, epilepsy, untreated hypothyroidism, severe panhypopituitarism and hypoadrenalism (an Addisonian crisis may be precipitated if there is no adrenal reserve).
- Procedure:
- Blood is taken for growth hormone, cortisol and glucose and then fast-acting insulin is injected intravenously. Blood is taken again for growth hormone, cortisol and glucose after 30, 45, 60, 90 and 120 minutes.
- The test cannot be interpreted unless hypoglycaemia (<2.2 mmol/L) is achieved. There must be at least two specimens following adequate hypoglycaemia.
- Interpretation: an adequate growth hormone response occurs with an absolute response >20 mU/L (6 μg/L).
See also separate Adrenal Insufficiency and Addison's Disease article.
- Cortisol. Serum cortisol level is measured at around 9 am. If low, ACTH deficiency is likely unless the person is taking steroid medication. Measurement of salivary cortisol may be helpful in determining hypothalamic-pituitary-adrenal (HPA) axis activity under normal conditions and in response to stress. However, factors such as the time the sample was taken, activity and stress can all affect cortisol level.[3]
- Synacthen test:
- Measures the adrenal response to ACTH.
- Plasma ACTH should be measured at the same time as the ACTH stimulation, although this test is considered to be inaccurate. The ACTH plasma and ACTH stimulation test together can give a clearer picture, especially in the case of secondary adrenal insufficiency.
- Patients taking oral steroids must omit them on the morning of the test but take them as soon as the test is completed. Oestrogen-containing medications should be stopped for six weeks prior to measuring serum cortisol.
- Synacthen® (an ACTH analogue) is administered as an intravenous bolus with measurements of cortisol (and for 17-hydroxyprogesterone where the test is being performed for possible congenital adrenal hyperplasia) at 0 minutes, 30 minutes and 60 minutes.
- This test has a high specificity but low sensitivity. Adrenal insufficiency is excluded by an incremental rise in cortisol of >200 nmol/L and a 30-minute value >600 nmol/L. In ACTH deficiency the response to the short test may be normal or reduced.
- A low-dose 1-μg ACTH stimulation test can be used to increase the specificity of the high-dose test. The low dose of ACTH does not stimulate cortisol production in an unprimed adrenal gland.
- Insulin tolerance/stress test (see 'Growth hormone', above):
- If there is adequate hypoglycaemia and the patient is not hypothyroid then the cortisol response is a good test of ACTH/adrenal reserve.
- An adequate cortisol response is defined as a rise to >550 nmol/L. However, 5-15% of normal subjects will show a suboptimal response as defined by cortisol <550 nmol/L.
- Glucagon can be used as an alternative to insulin for stimulating production of ACTH. Glucagon is particularly useful when insulin-induced hypoglycaemia is contra-indicated
- Metyrapone test: metyrapone blocks adrenal hormone production and normal individuals respond by producing large amounts of ACTH. Lack of response indicates pituitary disease affecting ACTH production.
- Single measurement of plasma dehydroepiandrosterone sulfate levels have been shown to be at least a reasonable screening test for ACTH deficiency, with good sensitivity and specificity.[4] Normal levels are age-dependent and the laboratory must have age-matched control normal levels available.
Gonadotrophin deficiency
- Gonadotrophin deficiency is difficult to assess in girls prior to puberty or in boys after age 3-6 months and before puberty.
- Follicle stimulating hormone (FSH), luteinising hormone (LH) and either estradiol or testosterone (as appropriate for sex): hormone deficiency can be difficult to assess and hormone levels can be particularly affected by stage of puberty and menstrual cycle. In gonadotrophin deficiency, however, basal levels are often enough for diagnosis, without stimulation testing as below.
- GnRH testing:
- The main use is to confirm precocious puberty rather than deficiency.
- Samples are obtained to measure LH and FSH levels at baseline and at 20 minutes and 60 minutes after giving a short-acting GnRH analogue. Samples for testosterone (males) and estradiol (females) are also taken at the baseline.
- In healthy pubertal children, both LH and FSH should at least double at 20 minutes and LH response is usually greater. In normal prepubertal children and patients with complete gonadotrophin deficiency, little to no response of either LH or FSH occurs.
- An intermediate response does not distinguish prepubertal gonadotrophin deficiency from simple delayed puberty.
Thyroid-stimulating hormone (TSH)
See also separate Thyroid Function Tests article.
- Thyrotrophin-releasing hormone (TRH) stimulation test:
- A TRH test may be indicated if secondary hypothyroidism is suspected.
- A small amount of TRH is given intravenously and then blood is taken for levels of TSH at several subsequent time points.
- Patients with normal function of the hypothalamic-pituitary axis respond by increasing the levels of TSH following TRH injection. Patients with compromised HPA function may exhibit a delayed, blunted or absent response to TRH administration.
- TRH stimulation test may be useful in the diagnosis of central hypothyroidism, especially if free T4 and/or TSH are low-normal.[5, 6]
Anterior pituitary hormone hypersecretion[1]
See also separate Hyperprolactinaemia and Prolactinoma article.
- Levels should be taken on at least two occasions and after relaxation if elevation is suspected. A single prolactin measurement may be sufficient if the value is >200 μg/L.
- Circulating prolactin levels are lowest at midday, with a modest increase occurring during the afternoon. Prolactin levels increase during rapid eye movement (REM) sleep, in response to stress and following meals.
See separate Cushing's Syndrome article.
Growth hormone
See also separate Acromegaly article.
- A single measurement of growth hormone is inadequate because growth hormone is secreted in a pulsatile manner during deep sleep. A series is taken.
- Serum IGF-I: measurement of serum IGF-I concentration is a sensitive screening test for acromegaly. Significantly higher IGF-I levels occur during puberty than those during adulthood. For accurate control comparison, the IGF-I level must be compared with that of control subjects who are matched for age, gender and Tanner's stage.
- Serum IGFBP-3: increased IGFBP-3 level has been reported as a sensitive marker of growth hormone hypersecretion.
- Inability to suppress serum growth hormone levels during an oral glucose tolerance test (OGTT): the single best laboratory criterion for diagnosing growth hormone excess is failure to suppress serum growth hormone levels to >5 ng/dL within three hours after an oral glucose challenge.
See also separate Precocious Puberty article.
- A random LH is a useful initial test for precocious puberty. A random FSH will not distinguish prepuberty from puberty. Low or prepubertal levels with high sex steroid levels are found in gonadotrophin-independent precocious puberty.
- GnRH stimulation test: as in the gonadotrophin deficiency section above, LH and FSH levels are measured sequentially after GnRH stimulation. The test is useful in the assessment of precocious puberty.[7]
- Leuprorelin acetate stimulation testing is an alternative and can accurately predict pubertal progression.[8].
Posterior pituitary[1]
The posterior pituitary produces antidiuretic hormone (ADH) and oxytocin, which stimulates uterine contraction during birth and ejection of milk during lactation. Patients with suspected diabetes insipidus are usually assessed by a water deprivation test. Alternatively, a non-osmotic stimulus such as hypoglycaemia may be used to stimulate ADH secretion.
- Initial tests: plasma glucose, U&Es; plasma and urine osmolality.
- Water deprivation test :
- The water deprivation test is used in the differential diagnosis of polyuria, differentiating between cranial diabetes insipidus (CDI), nephrogenic diabetes insipidus (NDI) and primary polydipsia (compulsive water drinking).
- Anterior pituitary hormone deficiency: renders results meaningless as, in particular, steroid and thyroxine deficiencies impair excretion of a free water load.
- For patients with true CDI or NDI, there is a risk of excessive dehydration.
- Stage 1 (exclusion of primary polydipsia) - 8.30-16.30 hours:
- No fluids are allowed. the patient is weighed at the beginning of the test and at hourly intervals. This stage of the test should be stopped if there is more than 3% weight loss (positive test).
- Urine is passed and discarded at the beginning of the test and then passed hourly and tested for hourly urine volume and osmolality. Blood is taken for osmolality at intervals during the test.
- Stage 2 (differential diagnosis CDI from NDI) - 16.30-20.30 hours: the patient may eat and drink freely. DDAVP® is given either intranasally or intramuscularly and hourly urine volumes and osmolality measurements are continued.
- For interpretation of results and other investigations for CDI and NDI, see the separate Diabetes Insipidus article.
Further reading and references
Investigation protocols; Biochemical Investigations in Laboratory Medicine,
A-Z of diagnostic tests; EndocrineSurgeon.co.uk
Investigation protocols and patient information sheets; Endobible
GP Factfile; The Pituitary Foundation
Jessop DS, Turner-Cobb JM; Measurement and meaning of salivary cortisol: a focus on health and disease in Stress. 200811(1):1-14. Epub 2007 Jul 16.
Fischli S, Jenni S, Allemann S, et al; Dehydroepiandrosterone sulfate in the assessment of the hypothalamic-pituitary-adrenal axis. J Clin Endocrinol Metab. 2008 Feb93(2):539-42. Epub 2007 Nov 6.
Koulouri O, Moran C, Halsall D, et al; Pitfalls in the measurement and interpretation of thyroid function tests. Best Pract Res Clin Endocrinol Metab. 2013 Dec27(6):745-62. doi: 10.1016/j.beem.2013.10.003. Epub 2013 Oct 17.
Atmaca H, Tanriverdi F, Gokce C, et al; Do we still need the TRH stimulation test? Thyroid. 2007 Jun17(6):529-33.
Kandemir N, Demirbilek H, Ozon ZA, et al; GnRH Stimulation Test in Precocious Puberty: Single Sample is Adequate for diagnosis and dose adjustment. J Clin Res Pediatr Endocrinol. 2011 Mar3(1):12-7. Epub 2011 Feb 23.
Sathasivam A, Garibaldi L, Shapiro S, et al; Leuprolide stimulation testing for the evaluation of early female sexual maturation. Clin Endocrinol (Oxf). 2010 Sep73(3):375-81. Epub 2010 Feb 23.


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Combine Internet Connections To Stream Videos Faster With VideoBee [Android]
Have you ever been in a situation where you're watching online videos on your Android device but your Internet connection just isn't quite fast enough? Maybe your mobile connection is a little on the slow side, and the WiFi connection available to you isn't that much faster either. Wouldn't it be great if you could just combine your mobile and WiFi connections to get a faster Internet connection so that you can watch online videos seamlessly?
Well, with VideoBee you can make that a reality. VideoBee is an Android app that enables you to combine your WiFi and mobile connections to boost your video streaming speed. As long as you have 2 separate Internet connections, you can use VideoBee to combine them – be it WiFi + mobile or WiFi + WiFi. You can also pair up with a friend and go with the mobile + mobile combination. What's more, you don't even need a rooted device to use the app.
Recommended Reading: Keeping Your Private Photos/Videos Hidden On Android
Start Using VideoBee
First, download the app here. Then, decide on the network that you want to use for streaming online videos. If you are using a device that has a mobile connection (e.g. a smartphone or 3G tablet), you should select the WiFi and Mobile option. If your device has no mobile connection, then your only option is to select the WiFi option and connect with another device that has a mobile connection.
To take advantage of VideoBee's features, you will need more than one Internet connection, be it mobile or WiFi. You will also need to make sure that both the Internet connections are stable. Once those requirements are met, you can use VideoBee in either solo mode or group mode.
Solo Mode
If you have both a WiFi and Mobile connection, you can take advantage of this app even in solo mode. Just select the Wifi and Mobile option, and try streaming a video using VideoBee to see how much faster your streaming speed has become than it usually is. For a clearer illustration, take a look at our example below, where we combined a WiFi connection (3.3 Mbps) and a mobile connection (2.7 Mbps).
Group Mode
You can also create a group to automatically boost each other's video. To do that, select the Create a new group option and turn on your Bluetooth connection to make your device visible to other devices for 120 seconds. Once the new group has been created, your friends can join the group by selecting the Join an existing group option on his or her device.
To use VideoBee in group mode, make sure at least one friend has already joined your group. Group mode supports the following combinations: WiFi + Mobile, WiFi + WiFi, Mobile + Mobile.
If you want to share a video with your friends, you can tap on Local (top right corner) to share the video locally with whoever you have paired with in the group. You can also share videos via Facebook and Twitter.
At the time of writing, VideoBee is still in open beta and as such, the app only supports YouTube, Metacafe, Vimeo, and NBC. Also, the app only allows a maximum of 2 members/devices per group for now. But rest assured that updates and more features are on the way, according to the developers.


text: Digital New York Times Co. Will Try to Sell Off Boston Globe Amid ad struggles, publisher looks to shed assetsBy Charlie Warzel|February 20, 2013 Share By Charlie Warzel|February 20, 2013 Share The New York Times announced it planned to unload The Boston Globe and its related properties, which would further strip the company of assets outside of the paper of record. As Bloomberg News reported earlier, and the Times confirmed, the company is working with Evercore Partners, an independent investment firm, to assist with the process. The properties in the New England Media Group that are for sale include the Globe along with the Worcester Telegram & Gazette and their respective Web sites and GlobeDirect, the Globe's direct mail marketing company. "Our plan to sell the New England Media Group demonstrates our commitment to concentrate our strategic focus and investment on The New York Times brand and its journalism," Mark Thompson, president and CEO of The New York Times Co., said in a statement. He added: "We are very proud of our association with the Globe and the Telegram & Gazette, but given the differences between these businesses and The New York Times, we believe that a sale is in the best long-term interests of these properties and the employees who work for them as well as in the best interests of our shareholders." The Times Co. has been shedding assets including regional newspapers and About.com, which it sold last August to Barry Diller's IAC/InteractiveCorp for $300 million. The company lost roughly $110 million in the About deal (it acquired the About Group in 2005 for $410 million). With the advertising business still dire for the Times Co., it's not unreasonable to suggest the paper will take a loss on the Globe sale as it has with properties like About.com. This past quarter, the company reported advertising revenue declined 8.3 percent to $265 million, with print ads down 10.2 percent and digital down 1.7 percent. The company purchased the Globe in 1993 for $1.1 billion. Looking toward possible buyers and asking prices, The Times' media columnist David Carr surveyed media types in 2009—the last time the paper put the Globe up for sale—who put the potential price tag anywhere between "a buck" and $300 million. The Times Media Decoder blog is reporting that the paper turned down an offer in 2009 for $35 million by a local investment group. As far as buyers, Twitter is full of jokes that former presidential candidate Mitt Romney should buy the paper. Business Insider editor in chief and notorious Internet troublemaker Henry Blodget has also playfully tweeted interest in the property, one of his usual gags when media companies go up for sale. Though the New England Media group includes some storied media franchises, it's unclear whether many will come forward to shoulder the risk. This month during the Times Co.'s quarterly earnings call, the firm noted the Globe had close to 28,000 digital subscribers. During the call Times Co. CFO James Follo said the paper has seen "kind of a steady growth" noting, "we don't see that trajectory changing dramatically." The Globe has also recently tinkered with its ambitious paywall, reducing the number of free articles on the site and clamping down on socially shared articles. Share http://adweek.it/2kETYGX copy Adweek Adweek