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Malignant Mesothelioma
(Note : for Links provided by Atlas : click)
|Assunta De Rienzo, Joseph R. Testa
|Department of Surgery, Brigham and Women's Hospital and Harvard Medical School (ADR); Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA (JRT) / firstname.lastname@example.com; email@example.com
(Note : for Links provided by Atlas : click)
1. Abstract
|Review on mesothelioma, with data on clinics, and the genes involved.
2. Identity
|WHO/OMS Classification
|Malignant mesothelioma is a rare, aggressive cancer usually associated with exposure to asbestos. Most (~80%) mesotheliomas originate from mesothelial cells lining the pleural cavity and are referred to as malignant pleural mesotheliomas (MPM); the remainder arise from mesothelial cells that line the peritoneum (15-20%), pericardium (1%), or tunica vaginalis (
3. Clinics and Pathology
|Asbestos is the major causative factor in the pathogenesis of MPM. Approximately 80% of MPM patients report histories of exposure (Prazakova et al., 2014), but it is unknown how asbestos exposure leads to cellular transformation of normal mesothelial cells. The remaining 20% of MPM cases without a recognized history of exposure to asbestos may be related to alternative factors, including radiation or thorotrast exposure (Carbone et al., 2002). Genetic predisposition can also play a prominent role in familial cases (Testa et al., 2011). Chronic inflammation related to exposure to asbestos fibers is thought to contribute to the etiology of MPM (Hillegass et al., 2010; Matsuzaki et al., 2012). Asbestos can be found in human lungs after many years, and asbestos fiber concentrations in lung tissues may not diminish significantly over time after exposure cessation (Feder et al., 2017). Recently, high mobility group box protein-1 ( HMGB1), a non-histone chromatin-binding protein that regulates nucleosome assembly and chromatin structure, has been proposed as one of the factors responsible for the initiation and perpetuation of the inflammatory response in MPM (Carbone and Yang, 2012).
|Approximately 3,200 new cases of mesothelioma are diagnosed in United States annually, and the incidence worldwide is expected to rise over the next two decades (Henley et al, 2013). MPM has a very poor prognosis, with the median survival being less than 12 months (Mineo and Ambrogi, 2012).
|The World Health Organization Classification of Tumors of the Pleura has recently updated the classification of MPM (Galateau-Salle et al., 2016). MPM is classified into 3 major histological subtypes accordingly to the morphology of the cells: epithelioid (≥90% epithelial-shaped cells), sarcomatoid (≥90% spindle-shaped cells), and biphasic (consisting of significant numbers of both epithelial-shaped and spindle-shaped cells). Although the histological classification remains the same, some distinctions have been made related to prognosis. For example, diffuse malignant mesothelioma (DMM) has been separated from other mesotheliomas, with a much better prognosis observed in localized malignant mesotheliomas (LMMs) and well-differentiated papillary mesotheliomas (WDPMs) (Galateau-Salle et al., 2016).
|Karyotypic studies and chromosome microarray analyses of MPM have shown that all chromosomes contribute to numerical and structural changes, with chromosomal losses being more common than gains. Several sites of chromosomal losses occur more frequently, e.g., monosomy of chromosome 22, which occurs in 60-70% of MPMs (Cheng et al., 1999; De Rienzo et al., 2016). Chromosome microarray and loss of heterozygosity (LOH) analyses have revealed frequent losses of specific sites in 1p, 3p, 4, 6q, 9p, 11q, 13q, 14q, 15q, 17p, 18q, and 22q in MPM specimens and tumor-derived cell lines (De Rienzo et al., 2000, 2001; Lindholm et al., 2007; Ivanov et al., 2009; Cheung et al., 2010), suggesting that tumor suppressor genes may reside in the deleted regions. In fact, subsequent mutation screening studies uncovered frequent mutations and/or homozygous deletions of specific tumor suppressor genes at several of these recurrent sites of chromosomal loss (see below). Although less common, recurrent chromosomal gains of 5p, 7p, 8q, 12p, 17q and 18q have also been documented in some studies. Notably, losses of 1p, 3p, 6q, 9p, and 22q often occur in combination, suggesting a multistep cascade involving the inactivation of multiple tumor suppressor genes critical in MPM pathogenesis (Murthy and Testa, 1999). Data on malignant peritoneal mesotheliomas are fewer than for MPM, but two recent DNA copy number studies have revealed that the genomic pattern in peritoneal tumors is similar to that described for MPM, including recurrent losses of chromosomal regions 3p21, 9p21, and 22q12, although differences were also observed. For example, in one report of peritoneal mesotheliomas, novel genomic copy number alterations included loss of 8p11.2 and gain of 15q26.2 (Chirac et al., 2016). In another report, Borczuk et al. (2016) compared DNA array-based findings from 48 epithelioid peritoneal mesotheliomas and 41 epithelioid MPMs to identify similarities and differences in copy number alterations. Losses in 3p, 9p and 22q were seen in tumors from both sites, although 9p and 22q losses were seen at a higher rate in the pleural tumors (p
|Patients receiving first line combination chemotherapy with cisplatin and pemetrexed have a median survival of about 12 months (Vogelzang et al., 2003). Some patients with early MPM who undergo multimodality therapy that includes surgical resection and chemotherapy may benefit significantly, with longer-term survival at 5 years seen in up to 20% of cases (Richards, 2009).
4. Genes involved and Proteins
|Work performed in the 1990s implicated tumor suppressor loci at two of the recurrent sites of chromosomal loss first identified cytogenetically and/or by deletion mapping. One of these loci, CDKN2A (Cheng et al., 1994), is located at 9p21.3, and the second, NF2 (Bianchi et al, 1995; Sekido et al., 1995), resides at 22q12. The identity of the critical 3p21 gene in mesothelioma remained a mystery until 2011, however, when somatic point mutations of BAP1, located at 3p21.3, were identified in 20-25% of sporadic MPMs (Bott et al., 2011; Testa et al., 2011). In 2012, a Japanese group reported frequent biallelic alterations of BAP1, including homozygous deletions of part or all of this tumor suppressor gene as well as sequence-level mutations, in 61% of sporadic mesotheliomas (Yoshikawa et al., 2012). Subsequent studies with newer next generation and multiplex ligation-dependent probe amplification platforms confirmed a similarly high incidence of BAP1 alterations in this disease (Lo Iacono et al., 2015; Nasu et al., 2015). Importantly, germline mutations of BAP1 have also been found in families with a high incidence of mesothelioma and other cancers, and the existence of a germline BAP1 mutation may predispose to the carcinogenic effects of asbestos (Testa et al., 2011).
|Gene Name
|Point mutations observed in 22-25% of MPM; additional ~40% may show deletions of one or more exons.
|Gene Name
|Locus consists of overlapping genes encoding tumor suppressors p16(INK4) and p14(ARF), both of which are usually inactivated in MPM due to loss of shared exon 2 sequences. Homozygous deletions are observed in ~90% of MPM cell lines, and heterozygous and homozygous deletions are detected by FISH in 75-80% of primary MPMs.
|Gene Name
|LOH due mostly to monosomy 22 in 60-70% of MPMs; point mutations observed in 25-55% of MPMs.
|Gene Name
|Mutated in 15-20% of MPM, often reciprocally with p19(ARF) loss.
|Gene Name
|Point mutations observed in 8% of MPMs; biallelic gene inactivation in up to 27% of MPMs.
5. Result of the chromosomal anomaly
|Hybrid Gene
|While most MPMs have complex genomic profiles consisting of numerous genomic imbalances, two peritoneal mesothelioma cases were reported to have a t(14;22)(q32;q12) as the sole chromosomal aberration (see, by Ioannis Panagopoulos entry Mesothelioma: t(14;22)(q32;q12) EWSR1/ YY1:, http://atlasgeneticsoncology.usal.es/classic//Tumors/t1422q32q12MesotheliomID.html). More recently, among 25 mesothelioma patients aged 40 years or less, a subset of 4 cases (16%) were found to have EWSR1 / FUS - ATF1 fusions, including 2 patients with MPM and two with peritoneal mesothelioma (Desmeules et al., 2017). The fusion-positive cases displayed classic epithelioid morphology, immunoreactivity for cytokeratins and WT1, and negativity for S100. BAP1 expression was retained in the 3 fusion-positive cases with available material. Overall, features of this unique mesothelioma subset include young age at presentation, lack of asbestos exposure, and retained BAP1 expression.
6. Bibliography
|High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas.
|Bianchi AB, Mitsunaga SI, Cheng JQ, Klein WM, Jhanwar SC, Seizinger B, Kley N, Klein-Szanto AJ, Testa JR.
|Proc Natl Acad Sci U S A. 1995; 92(24):10854-8.
|Genome-wide analysis of abdominal and pleural malignant mesothelioma with DNA arrays reveals both common and distinct regions of copy number alteration.
|Borczuk AC, Pei J, Taub RN, Levy B, Nahum O, Chen J, Chen K, Testa JR.
|Cancer Biol Ther. 2016; 17(3):328-35.
|The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.
|Bott M, Brevet M, Taylor BS, Shimizu S, Ito T, Wang L, Creaney J, Lake RA, Zakowski MF, Reva B, Sander C, Delsite R, Powell S, Zhou Q, Shen R, Olshen A, Rusch V, Ladanyi M.
|Nat Genet 2011; 43:668-72.
|Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations.
|Bueno R, Stawiski EW, Goldstein LD, Durinck S, De Rienzo A, Modrusan Z, Gnad F, Nguyen TT, Jaiswal BS, Chirieac LR, Sciaranghella D, Dao N, Gustafson CE, Munir KJ, Hackney JA, Chaudhuri A, Gupta R, Guillory J, Toy K, Ha C, Chen YJ, Stinson J, Chaudhuri S, Zhang N, Wu TD, Sugarbaker DJ, de Sauvage FJ, Richards WG, Seshagiri S.
|Nat Genet. 2016; 48(4):407-16.
|The pathogenesis of mesothelioma.
|Carbone M, Kratzke RA, Testa JR.
|Semin Oncol. 2002, 29(1):2-17.
|Molecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma.
|Carbone M, Yang H.
|Clin Cancer Res. 2012; 18:598-604.
|p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma.
|Cheng JQ, Jhanwar SC, Klein WM, Bell DW, Lee WC, Altomare DA, Nobori T, Olopade OI, Buckler AJ, Testa JR.
|Cancer Res. 1994; 54(21):5547-51.
|Frequent mutations of NF2 and allelic loss from chromosome band 22q12 in malignant mesothelioma: evidence for a two-hit mechanism of NF2 inactivation.
|Cheng JQ, Lee WC, Klein MA, Cheng GZ, Jhanwar SC, Testa JR.
|Genes Chromosomes Cancer. 1999; 24:238-42.
|The promyelocytic leukemia zinc-finger gene, PLZF, is frequently downregulated in malignant mesothelioma cells and contributes to cell survival.
|Cheung M, Pei J, Pei Y, Jhanwar SC, Pass HI, Testa JR.
|Oncogene. 2010; 29(11):1633-40.
|Genomic copy number alterations in 33 malignant peritoneal mesothelioma analyzed by comparative genomic hybridization array.
|Chirac P, Maillet D, Leprêtre F, Isaac S, Glehen O, Figeac M, Villeneuve L, Péron J, Gibson F, Galateau-Sallé F, Gilly FN, Brevet M.
|Hum Pathol. 2016; 55:72-82.
|Loss of heterozygosity analysis of 13q and 14q in human malignant mesothelioma.
|De Rienzo A, Jhanwar SC, Testa JR.
|Genes Chromosomes Cancer 2000; 28:337-41.
|A subset of malignant mesotheliomas in young adults are associated with recurrent EWSR1/FUS-ATF1 fusions.
|Desmeules P, Joubert P, Zhang L, Al-Ahmadie HA, Fletcher CD, Vakiani E, Delair DF, Rekhtman N, Ladanyi M, Travis WD, Antonescu CR.
|Am J Surg Pathol. 2017; 41(7):980-988.
|The asbestos fibre burden in human lungs: new insights into the chrysotile debate.
|Feder IS, Tischoff I, Theile A, Schmitz I, Merget R, Tannapfel A.
|Eur Respir J. 2017, 49(6).
|The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification.
|Galateau-Salle F, Churg A, Roggli V, Travis WD; World Health Organization Committee for Tumors of the Pleura.
|J Thorac Oncol. 2016; 11(2):142-54.
|Mesothelioma incidence in 50 states and the District of Columbia, United States, 2003-2008.
|Henley SJ, Larson TC, Wu M, Antao VC, Lewis M, Pinheiro GA, Eheman C.
|Int J Occup Environ Health. 2013; 19:1-10.
|Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model.
|Hillegass JM, Shukla A, Lathrop SA, MacPherson MB, Beuschel SL, Butnor KJ, Testa JR, Pass HI, Carbone M, Steele C, Mossman BT.
|Ann N Y Acad Sci. 2010; 1203:7-14.
|Genomic events associated with progression of pleural malignant mesothelioma.
|Ivanov SV, Miller J, Lucito R, Tang C, Ivanova AV, Pei J, Carbone M, Cruz C, Beck A, Webb C, Nonaka D, Testa JR, Pass HI.
|Int J Cancer. 2009; 124(3):589-99.
|Gene copy number analysis in malignant pleural mesothelioma using oligonucleotide array CGH.
|Lindholm PM, Salmenkivi K, Vauhkonen H, Nicholson AG, Anttila S, Kinnula VL, Knuutila S.
|Cytogenet Genome Res. 2007; 119(1-2):46-52.
|Targeted next-generation sequencing of cancer genes in advanced stage malignant pleural mesothelioma: a retrospective study.
|Lo Iacono M, Monica V, Righi L, Grosso F, Libener R, Vatrano S, Bironzo P, Novello S, Musmeci L, Volante M, Papotti M, Scagliotti GV.
|J Thorac Oncol. 2015; 10(3):492-9.
|Asbestos-induced cellular and molecular alteration of immunocompetent cells and their relationship with chronic inflammation and carcinogenesis.
|Matsuzaki H, Maeda M, Lee S, Nishimura Y, Kumagai-Takei N, Hayashi H, Yamamoto S, Hatayama T, Kojima Y, Tabata R, Kishimoto T, Hiratsuka J, Otsuki T.
|J Biomed Biotechnol 2012, 2012:492608.
|Malignant pleural mesothelioma: factors influencing the prognosis.
|Mineo TC, Ambrogi V.
|Oncology (Williston Park) 2012, 26:1164-75.
|Asbestos, chromosomal deletions, and tumor suppressor gene alterations in human malignant mesothelioma.
|Murthy SS, Testa JR.
|J Cell Physiol 1999; 180:150-7.
|High incidence of somatic BAP1 alterations in sporadic malignant mesothelioma.
|Nasu M1, Emi M, Pastorino S, Tanji M, Powers A, Luk H, Baumann F, Zhang YA, Gazdar A, Kanodia S, Tiirikainen M, Flores E, Gaudino G, Becich MJ, Pass HI, Yang H, Carbone M.
|J Thorac Oncol. 2015; 10(4):565-76.
|Asbestos and the lung in the 21st century: an update.
|Prazakova S, Thomas PS, Sandrini A, Yates DH.
|Clin Respir J. 2014; 8(1):1-10.
|Recent advances in mesothelioma staging.
|Richards WG.
|Semin Thorac Cardiovasc Surg. 2009; 21(2):105-10.
|Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer.
|Sekido Y, Pass HI, Bader S, Mew DJ, Christman MF, Gazdar AF, Minna JD.
|Cancer Res. 1995; 55(6):1227-31.
|Germline BAP1 mutations predispose to malignant mesothelioma.
|Testa JR, Cheung M, Pei J, Below JE, Tan Y, Sementino E, Cox NJ, Dogan AU, Pass HI, Trusa S, Hesdorffer M, Nasu M, Powers A, Rivera Z, Comertpay S, Tanji M, Gaudino G, Yang H, Carbone M.
|Nat Genet 2011; 43:1022-5.
|Pathohistological diagnosis and differential diagnosis.
|Tischoff I, Neid M, Neumann V, Tannapfel A.
|Recent Results Cancer Res. 2011, 189:57-78.
|Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma.
|Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, Gatzemeier U, Boyer M, Emri S, Manegold C, Niyikiza C, Paoletti P.
|J Clinical Oncol. 2003; 21:2636-44.
|Frequent inactivation of the BAP1 gene in epithelioid-type malignant mesothelioma.
|Yoshikawa Y, Sato A, Tsujimura T, Emi M, Morinaga T, Fukuoka K, Yamada S, Murakami A, Kondo N, Matsumoto S, Okumura Y, Tanaka F, Hasegawa S, Nakano T, Hashimoto-Tamaoki T.
|Cancer Sci. 2012; 103(5):868-74.
7. Citation
|This paper should be referenced as such :
|Assunta De Rienzo, Joseph R Testa
|Malignant Mesothelioma
|Atlas Genet Cytogenet Oncol Haematol. 2018;22(9):403-406.
|Free journal version : [ pdf ] [ DOI ]
|On line version : http://atlasgeneticsoncology.usal.es/classic/Tumors/MesotheliomaID5019.html
8. External links
|arrayMap ((UZH-SIB Zurich) [auto + random 100 samples .. if exist ] [tabulated segments]
|Disease database
|Malignant Mesothelioma
|REVIEW articles
|automatic search in PubMed
|Last year articles
|automatic search in PubMed
|© Atlas of Genetics and Cytogenetics in Oncology and Haematology
|indexed on : Wed Nov 28 16:26:09 CET 2018
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-Score: Worcester State University 10, Clark University 8
-Records: Clark (12-19), Worcester State (13-13)
-Location: Worcester, Mass. (Granger Field)
-The Lead: The Lancers of Worcester State University exploded for nine runs in the top of the sixth inning to propel them to a 10-8 final victory over the Clark University baseball team on Wednesday afternoon.
-Worcester State took the first lead of the game with a run in the top of the second inning. Senior Michael Ferrara (Easton, Mass.) led off with a double to left field and scored on a double to left center from his classmate Seth Leslie (Phillipston, Mass.) for the 1-0 lead.
-The Cougars responded with two runs in the bottom of the second. Junior Jackson Posnik (Wellesley, Mass.) reached on a fielder's choice and his classmates Rudy Sarro (New Fairfield, Conn.) and Ryan Ruhlin (Portland, Maine) both walked to load the bases. With two outs junior Dylan Horn (Sterling, Conn.) sent a two RBI single through the right side to score Sarro and Ruhlin for the 2-1 lead.
-After retiring the first three batters in the top of the third, Clark put up two more runs in the bottom of the inning. Junior Derek Lefebvre (Groton, Mass.) earned an RBI with a single to deep right field that scored junior Kyle Shaw (Litchfield, N.H.) from second. Lefebvre later came home on a wild pitch for the 4-1 advantage.
-Sarro singled up the middle in the bottom of the fourth, stole second and third, and ultimately came home on an RBI single to right field from Horn for the 5-1 lead. With a 2-2 count sophomore Chris Radovic (Fairfield, Conn.) lined the ball into right field to score Horn to give the Cougars the five-run lead (6-1).
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-The Cougars got one run back in the bottom of the seventh on an RBI double to center field from sophomore James Huber (Rochester, N.Y.) that scored Radovic to pull within three (10-7). Radovic added his second RBI of the game when he singled to right center in the bottom of the eighth to score Sarro and bring the Cougars within two (10-8). The Lancer's defense retired the first three Clark batters in the bottom of the ninth to clinch the 10-8 final victory.
-Horn finished 3-for-5 at the plate for the Cougars, with three RBI and one run scored. Radovic went 3-for-4 with two RBI and one run scored in the setback. Clark finished with 10 hits on the day.
-Miller led the Lancers at the plate with a 2-for-5 day including a homerun, four RBI, and two runs scored. Leslie finished 2-for-5 with two RBI while Worcester State put up a total of 14 hits in the victory.
-Sophomore Torsten Sloan Anderson (Shelburne Falls, Mass.) pitched 5.1 innings for the Cougars, struck out three batters, and allowed five runs scored (three earned). He falls to 0-1 on the season.
-Senior Josh Boucher earned the win on the mound for Worcester State and improves to 1-2 on the season. He pitched 4.1 innings, struck out three batters, allowed six hits and three runs scored. Freshman Aidan Abernathy (Methuen, Mass.) tallied his third save of the year for the Lancers.
-Clark travels to Coast Guard on Friday, April 19th for a New England Women's and Men's Athletic Conference (NEWMAC) games at 3:30 p.m.
-Worcester State hosts MCLA on Thursday, April 18th at 3:30 p.m.


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Dartington Crystal glasses emanates chicness and delicacy, just the perfect glasses for a white wine. Darlington Crystal is the dominant crystal producer in the UK since 1967. Each glass is handmade and are world-class quality. The producer's idea of luxury takes the form of a wine glass. On the client list we can mention Rolls Royce, P&O Cruises and Chivas Regal. Here we find the finest combination of classical wine goblets and opulent but elegant red and white wine glasses.
Waterford Crystal A world-wide famous producer is definitely somebody who knows how to design an amazingly beautiful wine glass. This producer creates magic glasses for specific wines such as Pinot Noir, Bordeaux, Chardonnay, Champagne and them most loved Sauvignon Blanc. Equilibrium, beauty and class are the key words for these wine glasses.
Chateau Baccarat are wine glasses which speak about you. Holding a glass of this nature only gives you power and everyone will look at you amazed. These glasses have a fabulous prestige being very expensive. King Louis XV was in love with these beauties. For a wine glass to be created the most talented and finest designers in the world are asked to find the magic potion because these glasses are limited edition and collectors die to have them.
Spiegelau the title of these glasses is actually a synonym with glass. Its owner Fritz Pretzfelder gave this name to his business in 1926. In 2004 the business was bought by Riedel becoming Riedel/Nachtmann/Spiegelau. Thanks to a long history and amazing style, the result is absolutely marvelous.
Bottega del Vino Crystal glasses which bring Italy in your hands. Because of a powerful love for wine, Severino Barzan wanted to create something famous, a piece of art which remains deep in your mind. He desired to create glasses which will make wine look fabulous and because he only drank expensive fine wines his wish was to design a glass that will encapsulates the beauty of the wine so he created something unique. His glasses are sold around the entire world.
Schott Zwiesel are two brands created by Zwiesel Kristallglass AG, a world-wide famous glass producer who designs art since 1872. Since 1990 the company uses a high-quality cut glass which is 100% lead oxide free. This producer thinks first of all at the environment but still succeeds in creating the second best quality wine glass on Earth and he keeps receiving awards.
Riedel these glasses are the most expensive and elegant pieces of art you can hold in your hands. Being an Austrian company which creates glasses for over 250 years, we can easily say that the elegance of these marvels is outlandish. Their secret is innovation and creativity. They were the first who introduced the specific glass shapes for specific types of wine. Their intention is to offer an experience of taste which can only occur when you drink your wine from an astonishing glass. In 2000 the "O" series of wine glasses was released and people gone crazy about them.


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There is a lot of scientific evidence that nutritional supplements have beneficial effects on both male and female fertility. These supplements can be very effective in restoration of the hormonal balance, as well as improving overall health. You need to add supplements to your daily ration because even the best diet doesnt contain all the necessary nutrients.
Folic Acid
Folic acid is known for its ability to prevent spinal bifida in newborns. Thats why it is essentially to get enough quantity of folic acid before and during pregnancy. Certainly folic acid is important in itself, but it is also part of the very important B-complex of vitamins. These vitamins are necessary to produce the genetic materials DNA and RNA. Together with vitamin B12, folic acid is responsible for keeping babys genetic codes intact. Dont forget about all of the B vitamins trying to become pregnant. Research has proven that B6 increases fertility and vitamin B12 improves low sperm counts.
Zinc is a vital nutrient for increasing fertility for both men and women. As zinc is an essential component of genetic material, its deficiency can result in chromosome changes that causes reduced fertility and an increased risk of miscarriage. Zinc is necessary to use effectively the reproductive hormones, oestrogen and progesterone, to make the outer layer and tail of the sperm.
Selenium is an antioxidant that protects the body from highly reactive chemical fragments called free radicals. Selenium prevents chromosome breakage, responsible for birth defects and miscarriages. High level of selenium increase sperm formation.
Essential Fatty Acids (EFAs)
Essential fats influence all systems of the human body, including the reproductive system. They are important for healthy hormone functioning. This essential fatty acid supplementation produces prostaglandins that are contained in the semen. Insufficient levels of prostaglandins cause poor sperm quality, abnormal sperm, poor motility or low count.


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U.S. Forest Service Launches Christmas Tree Cutting Permit Website
With Thanksgiving now behind us, the U.S. Forest Service is turning its attention to Christmas, which is less than a month away, launching a new "Open Forest" website aimed at making it easier for Americans to obtain a permit to cut down Christmas trees "in some national forests, following certain rules and regulations."
The website currently covers only four locations: Arapaho & Roosevelt National Forests in north central Colorado, Flathead National Forest in western Montana, Mt. Hood National Forest near Portland, Oregon, and Shoshone National Forest in northwest Wyoming.
The site walks users through the process, "whether it's your first time, or a long-standing family tradition," providing both the relevant rules and regulations specific to each forest before allowing users to pay for and obtain the appropriate permit. The site also provides maps, information on hours and dates of operation, and helpful tips for selecting the correct type and size of tree.
Although the site only covers certain areas at the moment, other national forests might also offer similar options through individual ranger district offices, with each forest setting its own license rates, as well as appropriate limits on the number of trees one permit covers, the types of trees, and where in the forest the trees may be rightly obtained.
The U.S. Forest Service will also soon put the final touches on the "People's Tree," the 75-foot fir tree that will sit outside the U.S. Capitol, having yesterday completed its 3,000 mile westward journey from Willamette National Forest in Oregon, just two days before the 2018 National Christmas Tree Lighting, a tradition that dates back nearly 100 years to the Coolidge administration, when First Lady Grace Coolidge "gave permission for the District of Columbia Public Schools to erect a Christmas tree on the Ellipse south of the White House."
The Forest Service has handled the selection and transportation of the tree for nearly five decades, bringing in trees from as far as Alaska.
Posted in Featured News


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Sue Quigley
Raised in the nuclear plains of Eastern Washington, Sue stole her sister's guitar (abandoned for boys) at 13 and started writing songs about getting out of town and living another life. After graduating from college, fighting forest fires all over the west and getting some heartbreak in, she settled in Seattle and started doing some open mics. It was finally after seeing mutual friend Brandi Carlile play that she got the guts up to put a band together and make an EP. Then a full length CD "Perfect Chaos". The single "Paper Tiger"from that cd was Runner Up for Song of the Year (Songoftheyear.com ).
She was one of the Top 15 finalists in Carla DeSantis' (Rockergrl) "Discoveries" Contest and has played the Viper Room in Hollywood, showcased twice at SXSW in Austin, TX and solo- toured the West Coast and Ireland. She has performed locally in her beloved Seattle at the Hard Rock, Tractor Tavern, Crocodile Cafe, Showbox, and for 6,000 Seattle Storm fans as halftime entertainment.
Sue has been featured in several festivals and showcases including "Rockrgrl" festival, Chicksinger Nite @NYC's famed Bitter End, Fremont Fair, FolkLife and Indie Grrl Showcase in Nashville. Some life happened in the past several years and that has afforded much new material about what our path is and where it's going, to be showcased in her brand new album "Little Wildernesses", recorded with noted producer, Jonathan Plum at London Bridge studios (Pearl Jam, Soundgarden, Brandy Carlile). Recently selected as a featured performer at Seattle Acoustic Fest and US Bank's "TourPossible" contest, Sue is extremely excited to get these songs out in the world to do what they can do for the listener- that's the key for her, connection with the listener on emotions and issues we all share from time to time and how we grow from challenges and have the courage to face all our "Little Wildernesses".


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Bicycle Accidents
Utilizing a bicycle as your primary way of transportation might be a powerful approach to conserving cash and receiving a good workout since odors are not emitted and they are better for the environment than cars. Yet, utilizing a bicycle comes with particular dangers, notably when you need to share the road with dangerous drivers.
Occasionally innocent bicyclists are harmed by dangerous drivers because they don't honor prerogatives and the rights of cyclists' property. In many instances, bicycle injuries are extensive due to the fact that they are subjected to the elements and are often being flung from their bicycle when hit by a driver. A bicyclist's injuries can cost a lot of cash in the long term, making it extremely difficult to keep a secure fiscal state. But if another individual is the explanation for the cost of your injury, perhaps you are to get the monetary help.
According to the National Highway Traffic Safety Administration, bicycle mishaps can happen virtually anywhere, however they do most often appear in high traffic areas, like parking lots, parks, and traffic lights. In such areas, the possibility of a bicycle injury accident is raised, especially if motorists are behaving unsafely.
Hazardous Driving Behaviors
Many bike injuries happen as an effect of harmful car drivers instead of other riders. As a result, these behaviors often exhibited by hazardous motorists present great difficulties for bicyclists:
- Quick or harsh turns
- Not yielding to bikers
- Not checking blind spots before changing lanes
- Utilizing mobile devices while driving
- Speeding
These behaviors are inherently hazardous, particularly for cyclists who may possibly be incapable of considering defensive action. Based on the Sampson Law Firm internet site, cyclists have legal rights when they might be struck by a dangerous motorist.Read More
The Worst Consequence of Negligence or Recklessness
There have been many instances in the past when major accidents have happened, such as a truck, while transporting hazardous substances, collides with a smaller vehicle, killing its driver, or a stone slab, from a building being demolished, falls on someone, killing that person on the spot.
Acting responsibly, so as not to put others at risk or cause injury to someone, does not need to be commanded through law, but since many individuals continue to act negligently or recklessly, laws need to be made and enforced strictly to keep people from being unmindful of the safety of everyone around them.
These laws may concern traffic rules, the prohibition of the use of devices while driving, manufacturing responsibilities that will ensure product safety, the standard of medical care which patients deserve to have, safety in the workplace, and so forth.
According to the website of the The Benton Law Firm, wrongful death, which is the worst result of negligent or reckless acts, can be caused by a car accident, an accident in the workplace, harmful or defective products, medical malpractice, truck accident, pedestrian accident, or any other type of accident.
Despite the unintentional harm caused on the victim and in spite of having done everything possible in order to avoid causing any harm, there is one presupposed factor of negligence, called strict liability, which will make the law still hold the negligent or reckless person totally liable for the accident and all its consequences.
Funeral expenses, lost wages, and loss of companionship as among the major effects of wrongful death, more than enough to cause the family affected much trouble and emotional distress.
Filing a civil lawsuit against the liable party, however, may not be a simple endeavor for the grieving family since this legal move also requires much preparation and time in court which will only make the family members remember their loss. Thus, it would definitely be in the best interest of the affected family to contact any of the Houston personal injury lawyers, who will be able to provide the expert court representation that will enable the surviving members, also called "real parties in interest" to merit the full amount of compensation allowed under the law.Read More


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However, things have gotten a little out of hand lately. Though my clothing choices and certainly my shoe choices leave much to be desired, I've always kind of prided myself on carrying a nice purse. This isn't to make any sort of fashion statement, rather it's a way for me to feel okay about never switching bags. Even before I had kids I carried a big purse. It was usually something designer (Summer) and very versatile and would carry my books, my giant wallet, my phone, several tubes of Chap-Stick, and other random paraphernalia. When I did have kids, I started carrying this:
Which was big and fine and Gwen Stefani uses Skip Hop products so that makes it a little trendy, right? RIGHT??
And then my kids started getting really big. And MOBILE. See this video for an example:
I mean, seriously. They never stop. And so I figured it was time to stop trying to wrestle my giant diaper bag AND both banshees:
And get a backpack.
Yes, ladies. Think about it. Me in my Chacos, Target yoga pants, Whatever's-on-sale tank tops, and a backpack. No makeup. We won't discuss the hair.
Looking good.
Anyway, to save whatever shred of dignity I had left in the fashion department I did some due diligence and researched. Skip Hop has a back pack... it's way bigger than even I wanted. There are countless other varieties, all in the hundreds of dollars, and I passed on all of them. Too this, too that, not enough whatever...
Until I found this gem sitting in Anna's closet:
It is perfect. Perfect size, perfect amount of compartments. Easily wipeable on the inside and forces me to carry less stuff so I can wrangle these two:
What? That looks familiar, you say? Well, maybe I should zoom in on that white tag on the bottom, there:
Why, yes, fellow mommas. You have seen this bag before. The generous souls at Similac gave it to you in the hospital when you had your babies and your boobs were about to fall off from trying to nurse for the first time.
'Here,' the bag whispers. 'Take this, you poor, tired momma... and some formula...' I'm sure this backpack is still stained from the tears I wept in the hospital that first time, during nursing hell.
Ah, memories.
Inside I found the long-expired formula samples, and when I threw them out I realized that this backpack was the one. The ONE.
'You could at least cut the tag out,' a friend told me, thinking that she was saving me some humiliation. But no. That is not happening. I'm workin' this back, just like I'm workin' being a Mom. A woman in her thirties works it.
And with the money I saved buying a new backpack, I think some Anniversary Sale Frye boots might be in order.


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Lieutenant-General (R) Hamid Gul, the former Director-General of the Inter-Services Intelligence (ISI), has warned India again for interfering in the internal matters of Pakistan and maltreatment against Kashmiris.
Interviewing to a Pakistani news channel on April 17, 2015, Hamid Gul especially warned to the Indian Prime Minister Narendra Modi and Ajit Doval, the former Indian intelligence and law enforcement officer and current National Security Adviser to PM Narendra Modi, for making continuous threats and warnings to Pakistan.
There will be no friendship with India until the final solution of Maqbooza Jammu and Kashmir, he said this categorically. Thousands of Kashmiris have died through the indiscriminate use of force and torture, firing on demonstrations, custodial killings, encounters and detentions by the Indian Armed Forces. Rape also occurs during the crackdowns, he added.
In last of the interview, he openly threat the India and Indian Prime Minister. His words was, "Who is Narendra Modi? He is nothing in front of us. By God, we have all those resources, plans, and techniques that are sufficient to break India into pieces and we can."
He also criticised Pakistani Prime Minister Nawaz Sharif for keeping soft heart for Indians. He strongly condemned Nawaz Sharif on his past statement in which Nawaz Sharif had said that the Wagah Border is just a line between two countries. You (Indians) and we (Pakistani) are same. Nothing is different between us.
Shabir Ahmad Shah, the founder and president of the Jammu and Kashmir Democratic Freedom Party (JKDFP), was also called on for the interview. At the time of interview, he was internee. He said that we will struggle for Kashmir until its freedom. There is no kind of softness in our purpose.
Clip from the Talk Show:
Complete Show:
Tonight With Fareeha – 17th April 2015 by anees-malik


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Visakhapatnam or Vizag, the second biggest city in Andhra Pradesh,is the first in the country to have taken e-governance initiatives in early 2000. Today, many municipalities in India have replicated Visakhapatnam's e-governance model. Not just e-governance but its overall performance in environmental sustainability has helped the Corporation bag the prestigious Euro India's Environmentally Sustainable Cities Award (ESCA) in 2011. These days Greater Vishakapatnam Municipal Corporation (GVMC) is busy with another ambitious project that involves segregation of garbage at source. Municipal Commissioner B Ramanjaneyulu explains to CIJ, GVMC's solid waste management project and the Corporation's efforts in making a 'bin-less' city. Read More »
Author Archives: Preeti Swaminathan
Panaji:Towards a 'Bin-less' City
The sight of overflowing garbage bins is no more an issue with Panaji, capital of Goa, which started a 'bin-less city' campaign almost a decade ago. This is just one of the few initiatives Goa has taken to replicate successful ... Read More »
Akshay Patra leveraging innovation and automation to deliver Hygienic Food
The Akshay Patra programme, the world's largest school meal programme of a non-governmental organization, recently got an entry into the Limca Book of Records for providing hot meals to more than 1.3 million children at 800 schools, across 18 locations in eight states of India. The organisation owes a lot to its hi-tech and hygienic kitchens for the success. Read More »
School RESTROOM Issues
Frequent and effective cleaning is the key to achieve a healthy restroom environment in a school. Clean India Journal picks up the issue with a couple of schools… Read More »
Trichy City Corporation Tackling waste & sanitation issues
The famous temple town of South India, Tiruchirapalli, has been facing sanitation issues for long time now. The City Municipal Corporation along with a few self-help groups successfully launched a campaign to propagate sanitation, monitor residents' behaviour and supervise maintenance ... Read More »
Making Feminine Hygiene products affordable
For many Indian women "Feminine Hygiene" products are still beyond their reach. However, the 47-year-old school dropout from Coimbatore, Arunachalam Muruganantham brought about a revolution by inventing a machine that makes low-cost feminine sanitary products. Read More »
Effective waste management through mechanisation
Greater Hyderabad Municipal Corporation was awarded the "Best City" for 2009-10 for its efforts to improve Solid Waste Management under the Jawaharlal Nehru National Urban Renewal Mission. The Hyderabad Corporation's integrated waste management model includes transportation of waste to transfer ... Read More »
Labelled with care
Fabric care labels help the buyer in their purchase decision and the launderers in their wash decision Read More »
Interview with: Mahesh Pathak, Integrated Solid Waste Management: Pune creates A perfect model
Pune "The de-centralised waste management model adopted by Pune Municipal Corporation is one of the most successful in the country. This cost effective and eco friendly model has been highly recommended by Maharashtra government," says Municipal Commissioner Mahesh Pathak. What ... Read More »
Keeping city clean is a collective effort
In the recent years there is a significant shift in handling solid waste with Municipal Corporations across the country adopting various models of disposing and recycling waste. Pondicherry Corporation has successfully adopted door-to-door collection, transportation and processing model. Coimbatore Corporation has adopted house-to-house collection model and outsourced secondary collection and processing to private parties under PPP mode. In certain other cities, the processing has been outsourced on PPP basis. Besides waste collection, various technologies like composting, bio-methanation/gasification or high-temperature incineration and waste-to-energy are being used for waste management. For example, the service provider in Coimbatore Corporation had started with compost plant, now they are seeking permission to put up a waste-to-energy plant at their own cost. Bruhat Bengaluru Mahanagar Palike has forked out certain areas to be cleaned by sweeping machines. All Corporations are experimenting innovative methods to collect and treat waste. Ajit Patil, Secretary, Corporation of Cochin, in an exclusive interview with Clean India Journal, talks about how solutions to keep the city clean has been successfully implemented. Read More »
MCGM plans towards sustainable, garbage-free city
Mumbai has been facing a solid waste management crisis for years. In order to move towards a sustainable future by adopting integrated solid waste management approach, the Solid Waste Management Department (SWMD) of the Municipal Corporation of Greater Mumbai (MCGM) has joined hands with private contractors. The municipal corporation spends roughly र1160 per tonne on collection, transport and disposal of MSW. Collection and transport together constitute roughly 80% of the cost. In India, the average municipal expenditure on solid waste management is र500 to र1500 per tonne. B P Patil, Chief Engineer-SWM, MCGM, explains to Preeti Swaminathan the various projects lined up for integrated SWM. Read More »
10 minute act!!! Getting the multiplex spruced up between the shows
Multiplexes today are more than just places of entertainment. Red carpet welcome, auditorium ambience, comfortable pushback chairs and hot samosas / patties, popcorn, ice-cold cola… served at your seat. But the people seem to be unconcerned about the litter they throw around. Anita Rodrigues, Vice-President of Inox Leisure Ltd ensures that the auditorium is made spic & span minutes before a show begins. Wonder how she gets it cleaned? Preeti Swaminathan narrates with interest the 10-minute cleaning scene at Inox, Mumbai. Read More »
'Green Leaf' for Belgaum Corporation
City Corporation of Belgaum (CCB) has recently received the "Green Leaf Award" for the best municipal corporation for effective and scientific garbage disposal. The award constituted by Sukuki Exnora (Hyderabad) and assessed by ASCI (Administrative Staff College, of India), Hyderabad, ... Read More »
Interview with: Mayor AK Premajam, Thiruvananthapuram on a – Cleaning mode
Encouraged by the successful experiments by the Kozhikode Municipal Corporation in installing modern e-toilets for women, the Thiruvananthapuram Municipal Corporation has begun to procure these toilets for the city. Biju K, Municipal Secretary, Thiruvananthapuram Municipal Corporation, shares with CIJ the major cleanliness and hygiene initiatives he has taken since he took over charge four months back. Read More »
'Ladies Only': A response to nature's call Up until five years ago, every monsoon, the little tribal village of Gothangaon in the Nagpur district of Maharashtra would use up the entire stock of diarrhoea and gastroenteritis medication issued to the ... Read More »
Maintaining The BEST Buses
Travelling in a clean vehicle is probably the best way to begin a working day. RR Deshpande, Chief Manager-Traffic at Brihanmumbai Electric Supply and Transport Undertaking (BEST) understands this and has put in place an effective cleaning system to give a clean bus drive to commuters. Read More »
Street Cleaners' Woes
We have problems of paan stains, overflowing sewage waste or garbage on pavements. In fact, the problems lie with the way we look at the job of cleaning. How many of us ever thought about the people who actually work ... Read More »
Project Dharavi: Waste Matters for Green Workers
Dharavi, Asia's largest slum is a haven of dry waste – huge mounds of plastic bags, papers, scraps… It is also a home to several migrant workers, ragpickers and destitute and is probably the world's largest recycling quarters where almost ... Read More »
Taking pride in cleanliness
Cleanest City: I am proud of the city I live in. Being a well planned city, Chandigarh is one of the cleaner cities in India. And that is because the residents of Chandigarh take pride in their city and take ... Read More »
'We need to change our attitude'
Cleanest City: Smaller cities in India like Nashik and Nagpur in Maharashtra and Kanpur in Uttar Pradesh are not only well-maintained but green and clean. Mumbai needs to learn a lesson or two from these cities. Malaysia and Singapore are ... Read More »


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Thank you for designing such a useful website. It helped me alot. I am 32 yrs old , hop i can learn Bharatnatyam.
Thanks a ton again.
Four Points to consider with Ardhamandala Posture
Ardhamandala is the basic posture in Bharatanatyam. It is a recurring motif that gives the distinctive geometrical nature to the movements in Bharatanatyam. Considering the importance of this posture, I would like to share four things a new student needs to take care:
- Ensure that the feet is planted firmly flat on the ground. One of the common mistakes noticed is that the heels are raised.
- Avoid swaying of the waist. We should try and ensure that the waist movement is kept to a minimum when we do steps in this posture.
- When tapping the feet, maintain the Ardhamandal posture as you started. It is noticed that we tend to straighten the legs as we tap.
- There is a tendency to bend forward(when seen from the side) in Ardhmandal position. Try and keep the back straight.
Please check the video on Ardhamandala for a demonstration of above points.
Tags: Adavu · Araimandi · Ardhamandala · Ayatam · Bharatanatyam · Bharatnatyam · class · Classes · Dance · Learning · lessons · online · Steps
Leave A Comment
3 responses so far ↓
Thank you for designing such a useful website. It helped me alot. I am 32 yrs old , hop i can learn Bharatnatyam.
Hi Anjali,
Thanks for posting this information on the Aramandalam. I am currently completing a masters thesis on the aramandi position in particular. Do you have a source you have taken your explanations of aramandalam positions from? or is this based on your own experiences?
I have had a very difficult time trying to find a clear definition/ description of the aramandi in a reliable text such as the natya shastra or abhinaya darpana.
Anyhelp would be amazing and greatly appreciated! thanks again in advance
Do put a picture or Videos for paada beads…


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The student diary is intended to help students build organizational skills and take responsibility for their own learning, and to assist in communication between parents and staff.
Parents are encouraged to look through their son's diary to get a feel for his learning week, how his weekly notes are tracking and how they compare to his goals and what assessments he may have coming up.
In an effort to make the boys more accountable for their own learning, students are asked to set goals and make predictions for the coming week. This can then be compared with their weekly notes in each subject which will be written into their diary every Friday at form time.
All senior students are given an assessment outline for each subject which gives dates for internal assessments through the year. Boys are encouraged to use the diary along with a year planner, which is clearly visible in the place they regularly do their homework so that they are aware of the busy times for which they must plan.
Parents are always welcome to contact College staff directly; for non-urgent matters the student diary can be a helpful mode of communication.


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Our last port was Kota Kinabalu, Malaysia on the island of Borneo. Borneo is a large island with three different countries sharing it. Part of Indonesia is on this island as well as part of Malaysia, and the entire country of Brunei which was at one time the richest country per capita in the world because of its oil. The sultan is very very rich! Interesting little facts.
Malaysia is 65% Muslim. They eat no pork here – and in Thailand they eat only pork, no beef! Two of the main tourist attractions of this port are two gigantic beautifully manicured mosques. We visited their market which was disappointing compared to other markets we'd seen and then sat by the beach and checked our emails. The water was so nice and warm – I'm sure there are nice resorts here and in the outlying islands. This was a short excursion as we have a longer than usual trip back to Singapore. Getting back on the ship always requires going through immigration, everyone must have been on a tea break because there was no one there and we walked right through without being checked.
Back on the ship – our last day at sea – I was asked to participate in a jewelry fashion show. Donning two strands of Tahitian black pearls, one worth $20,000.00! Earrings to match and two beautiful 18mm pearl rings set with diamonds, I felt like a queen! It was fun to participate and nice to be chosen.
In the evening we passed several oil rigs all lit up like a hotel floating in the middle of the ocean with huge exhaust stacks burning off the excess natural gas. Quite a sight in the usual blackness of the night ocean. The cruise ship itself burns 40,000 gallons of fuel per day.
Our last day at sea and about 80 miles out of the Singapore harbour we start seeing container ships, one or two at first then many more. After seeing nothing but ocean in every direction this was different, a traffic jam in the sea! The closer we got the more ships appeared, then we were in the middle of hundreds of cargo boats of every size and shape for miles and miles. With the skyscrapers along the horizon the Singapore harbour is a sight to behold. The distinguishing building setting Singapore skyline apart from any other is three skyscrapers all joined at the top by a submarine looking structure full of trees and a huge swimming pool suspended between the top of these buildings. I'd read about this on the plane, the architect that won the bid for this job was a young man and this was his first project!
We've come to the end of our cruise. Excellent entertainment every night, being waited on hand and foot, the wonderful meals, the fun excursions, our bed made for us everyday – it's going to be hard to come back to the real world!
I've so enjoyed reminiscing with my brothers and hearing stories I've never heard before, learning to appreciate them in a whole new way and loving them for who they are. Thank you both for being so generous, loving and kind to me your baby sister. With them I will always be the baby and will always feel young 🙂
I am so aware of my privileged place of birth, standard of living and most of all Christian heritage. I am so grateful, my heart is full.


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We are inviting all egg-heads in the area to attempt a very special challenge. Can you protect an egg from a drop? Plan to take a crack at the challenge. Just try not to get too much egg on your face.
Any PK-12 grade student attending the Mini Maker Faire.
The Egg Drop Challenge will have four age group divisions.
Preschool/ Kindergarten
Grades 1-4
Grades 5-8
Grades 9-12
Competition requirements will vary between the age- group divisions.
All materials to used in the challenge will be provided on the day of the Mini Maker Faire( eggs included). This is a timed, onsite drop challenge.
Chicken eggs. Photograph. Britannica ImageQuest, Encyclopædia Britannica, 31 Aug 2017.
quest.eb.com/search/132_1514992/1/132_1514992/cite. Accessed 7 Mar 2018.


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The Wild, Wild East
Painstakingly shot over a period of five years on a nature reserve in Tower Hamlets, captured by means of camouflage, bait and remote camera shutter control. It includes a number of favourite subjects that became less camera shy and more camera friendly as the years went by.
Bites and Stings
Ever tried to photograph invertebrates in a field on a warm sunny day? Sit in the grass long enough and you'll soon discover the prickle of thistles, the pain of nettles and the bites and stings of ants, bees, wasps, beetles, mosquito's and a host of other flies. There are all sorts of spiders to contend with too!
The Photo of the Month Gallery
Comprised of nature images courtesy of contributors to the Photo of the Month Calendar scheme. Subject to terms, the scheme is open to any photographer wishing to advertise their name, work or website here for free! Places are offered on a first come first served basis and the number of places available for the year as well as submission times can all be found on the PotM Calendar. To learn more about showing one of your nature images here go to the PotM Calendar Terms of Use page.
------------ Photo courtesy of Dave Savva, Alchemy Street Film Making for Communication and Interaction. ------------
------------ Photo courtesy of Dave Savva, Alchemy Street Film Making for Communication and Interaction. ------------
About Country
What's the number one personal accessory we like to use the most on a British holiday, a weekend break or day trip? Not counting the car, credit card and mobile phone that is. What?! Sun tan lotion?! Behave yourself! No, next to an umbrella it's a camera. So what else but a busman's holiday snapshot album of wildlife encountered away from home.
Neighbourhood Watch
Wildlife opportunities watched for and created on weekend walks around the neighbourhood and city. It features a surprising number of approachable subjects. From a hand reared buzzard on the verge of being wild to a friendly grey squirrel on the verge of being tame. Be it native, escape or invasive, it's wildlife on the streets from my doorstep to the park in world of asphalt, concrete, glass, iron, wood, plastic, brick and stone.


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Rockford, Illinois Lawyers
Find Rockford, Illinois Attorneys by Practice Area
- Agricultural Law
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- Antitrust Law
- Appeals & Appellate
- Arbitration & Mediation
- Asbestos & Mesothelioma
- Cannabis & Marijuana Law
- Civil Rights
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- Communications & Internet Law
- Construction Law
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David M. Barish
Illinois Attorney with 37 years experience
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Angela Lund-Logan
Machesney Park, IL Attorney
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David N. Metnick
Rockford, IL Attorney
(800) 390-6350The John Marshall Law SchoolUniversity of ArizonaIllinoisMothers Against Drunk DrivingState Bar of IllinoisInsurance Company Tries to Low Ball Client Based on Age and Insurance Settles for 5x More Than Initial Offer
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Rockford, IL Attorney
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Rockford, IL Attorney
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The Director of Business Sales (DBS) will take ownership of the entire sales cycle for Business to Consumer (B2C) sales for UPEDS. The DBS will manage a team of sales associates who will be responsible to drive sales opportunities and achieve revenue objectives. This position requires an individual who can engage at the highest levels of an organization both externally and internally, as well work "in the trenches". Our ideal candidate is an inspiring team player, has outstanding communication skills, superior follow through skills, can build consensus among disparate groups, and understands UPEDS methodologies, offerings, and workflows. This position requires an experienced perspective that can creatively find opportunities to add value to the industry, effectively navigate B2C sales through negotiations to close as well as advise VP of Sales through regular sales status updates.
- Minimum 3 years of experience with inside/outside sales with proven records of year-over-year revenue increases with B2C or B2B sales
- Demonstrated ability to communicate, present and influence credibly and effectively at all levels of target organizations; including executive and C-level
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Build and strengthen your business relationship
To learn more, please visit UPEDS-Careers


text: Tyler was born and raised in Worthington, Ohio. In 2004, at the age of 18, he enlisted in the United States Marine Corps as a Data Network Specialist and was stationed in Okinawa, Japan. After three and a half years and many travels throughout the Pacific Theater he decided to pursue a different path. In 2008 Tyler was selected and accepted into the Explosive Ordnance Disposal Technician program and successfully graduated in 2009. He was then stationed in North Carolina with 2nd Explosive Ordnance Disposal Company, Camp Lejeune, NC. After two tours in Afghanistan and eleven years of service Tyler chose to step away from active duty to pursue other opportunities. Since stepping out Tyler has continued to work in the explosives industry. He has worked as a Pyro Technician where he trains young Marines for upcoming deployments using small explosive charges to simulate some explosive threats they may face. He also works as an Unexploded Ordnance Technician where he travels to various locations within the United States and removes explosive hazards from the local areas, making them safer for military personnel and civilians alike. Tyler's training, dedication, and focus under high pressure situations has prepared him for many challenges faced in the civilian market. His attention to detail both on and off the battlefield make him an excellent candidate for managing personnel and exceeding any and all tasks presented to him. Tyler is currently the Chief Operations Officer at Athena's Owl where he is joined by his fellow Veterans who bring a passion for continuing to serve their community by highlighting various events and installations using aerial photography and videography. Tyler, like the rest of the team, are thrilled to meet and exceed all expectations from their clients and continue to represent the Veteran community with pride and honor.


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The background of knickknack throughout time is not really a great deal of an account of human vainness than the usual reflection from the evolution of human societies along with the urge of individuals to develop symbols and wonder.
Jewels across time
You'll find symptoms that human beings happen to be https://www.hsjewellers.com.au/ from very early situations on as personalized adornment. Originally, these have been product of elements quickly available in character these types of as shells, animal bones or teeth. With time individuals learnt to operate with distinct stones and metals, which includes gold and gems which were particularly valued in jewellery. Our ancestors had been exceptionally gifted jewelers as well as attractiveness and splendor on the old jewels even now fascinates us as obviously shown through the curiosity revealed for jewel shows in museums or for itinerary exhibitions on one example is the Gold of your Incas or maybe the treasures from Egyptians tombs.
Along with the utilization of important metals like gold or gems like diamonds, jewels grew to become tangible indications of prosperity, electric power and societal purchase. At diverse instances, like inside the Center Age, legislation had been passed as to who was allowed to wear jewels, which in alone illustrates the social worth attached to jewels.
The idea of crown jewels was developed from the Renaissance time period wherever the French King, Francois 1st declared 8 wonderful pieces being inalienable heirlooms of French kings.Very similar laws in other international locations shortly laid the ground for that treasures in the European Royal family members.
nineteenth and 20th century, a turning stage
The use and importance of jewels transformed drastically during the nineteenth century due to social, technological and cultural variables.
A different social code – Till then men put on just as sumptuous jewels as ladies did. Also they had important stones, pearls, gold and silver threads sawed into their garments. On the other hand, around the nineteenth century the social code demanded a more sober gown code for men. Moreover, round the exact same period of time, a a lot sharper differentiation was launched amongst day and evening jewels, essentially the most sumptuous remaining reserved for evenings and galas.
A brand new technological know-how – The commercial revolution designed it doable to mass generate jewels of high- too as low-quality, as a result placing jewellery within the financial grasp of a much bigger section with the populace. This in turn led to a far more peaceful relation to jewels obtained in a decrease expense and easily replaced by new collections for your rapidly modifying manner.
The modern society – The Art Nouveau motion plus the 1900 Globe Exhibition marked a whole new period exactly where structure and creativity are prized earlier mentioned substance price, hence shifting the emphasis in the jeweler's artwork through the environment of stones into the artistic style and design. This marked the delivery of what's now called artwork jewellery instead of regular jewelry.
During the Artwork Deco interval Coco Chanel significantly popularized costume jewelry as ornamentation to enrich a selected stylish costume or garment. These costume jewels usually product of non treasured product and mass-produced marked the beginning of the era of disposable jewels that happen to be trendy for any shorter time period and quickly outdated by a whole new style fashion.
1 can't point out style and design devoid of mentioning the Danish Style. This impressive motion is characterized by very distinct sober spherical traces of great esthetic top quality and a predilection for silver. Georg Jensen is easily the most emblematic determine, but absolutely not the only real renowned name. Danish Style and design had a big impact from the rest of Europe and in the US and laid the ground for many experimental jewels during the nineteen sixties an nineteen seventies.
Jewel style and design did not only experimented with new varieties and new product – which includes cheap products like aluminum, plastic, paper, nylon, but haute-couture designers such as Coco Chanel, as mentioned earlier mentioned, and renowned artists like Salvador Dali, Picasso or Max Ernst created a big contribution to innovation in that subject. This function challenged constricting conventions and rather blurred the boundaries amongst jewelry, style and high-quality arts.
Jewels now and tomorrow
Jewels are only appealing right now since they were being in the earlier. It's not attainable at this point to foresee what the 21st century will carry as novelty. Having said that, taking a look at what's happening right now could give us a hint concerning tendencies.
Artwork jewels
One particular in the indications of the ongoing economic and cultural worth of jewels in present day culture is the once-a-year Copenhagen Jewellery Good that is definitely Scandinavian largest jewellery and check out good. This 12 months, the royal defense of your honest, Princess Marie, delivered the prize to your winder with the "Bella Nordic Jewelry Award", which can be regarded as that Nordic levels of competition for jewelers.
While, away from that glamour, yow will discover lots of modest jewel designers' ateliers scattered around Denmark. There, you can find wonderful one of a kind jewels established by gifted people with a enthusiasm for his or her craft and proposing a great range of layout and realization.
Home-made jewels
The large price of high-quality jewels has paved how for the "do it yourself" motion. You can find rather a sizeable quantity of physical or digital shops were being non-public shoppers can purchase jewels elements which they can then assembled to create jewels for themselves or other people. These outlets are already until eventually now be considered a worthwhile business, but there are actually now indication the marked is coming to saturation and competitiveness is now tougher.
Jewels, usage modern society and recycling
As stated previously, jewels can be a reflection of societal developments. On just one aspect mass output with low-cost materials has meant a massive supply of jewels that everyone can pay for. Individuals jewels are getting to be everyday objects of use to be used and discarded without a 2nd imagined
To be a reaction to this "waste society" recycling has grown to be a robust societal movement. Squander substance, even trash, is utilized to new creations, including jewels. Those are per definition distinctive items coming out from the designer's imagination and offered at price ranges considerably fluctuating with all the popularity in the designer.
Jewels for men
When there appears to be no restrict of sizing, colour and composition in women's jewels, the give and usage of men's jewellery is relatively pretty limited. It truly is hard to mention whether or not this is thanks to men themselves, to societal norms on what a person can wear or due to your lack of curiosity and creativity over the section of the designers. It really is nevertheless far more and even more accepted for men to put on earrings, which could be a indication that conventions and taste are switching.
Jewelry – an eternal appreciate tale
Jewels have adopted human beings all over ages and possess experienced a social and cultural job which has advanced hand in hand with societies. Inside our advanced modern culture jewels, in a single form or yet another, are very affordable to all levels of culture and so are utilized as indicators on attitudes, life and belonging. The cultural significance of jewels is tough to ascertain in view of the great provide and variety of jewels through the low cost mass-produced for the greatest special pieces. As Clare Phillips1 states "What continues to be correct now, as during the ages, is jewellery at its very best has the facility to fascinate and inspire – that is the primary characteristic of artwork at its ideal in any of its quite a few manifestations." It can then be conclude devoid of any question that, indeed, jewels tend to be much more than an expression of human vainness.


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Pivot Design Round Two
Looks like we did a great job for our first project with Pivot Designs out of Chicago. Pivot has called us again for a second project. This shoot will take place in in San Antonio, TX. Stay tuned for more details and photos of the Alamo's basement. 🙂


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Beaten in a truck crash see an Austin Injury Lawyer
Austin is one of the largest cities in Texas, where car accidents occur
in the blink of an eye. Reckless drunk, texting and speeding drivers rob
you of living life to the fullest in a tragic instant. The ability to
earn a living and enjoy time with friends and family is single-handedly
destroyed by serious bodily injuries. Life is not fair, but a fair
settlement is and attorney Greenway intends to fight for just that. He
pursues the maximum financial compensation you are rightly entitled to
after an Austin car accident. Your future is our sole concern the moment
you seek our services, so let our car accident lawyer Austin help you.
to the Texas Department of Transportation, an alarming 63,610 personal
injury accidents occurred in 2012 and of those accidents, 87,087 victims
sustained serious bodily injury. The year's report also highlighted
3,018 fatal accidents which claimed the lives of 3,399 individuals
statewide. Texas law delegates that you have two years from the date the
accident occurred to file a lawsuit. Discuss your legal options and
rights with attorney Greenway if you have suffered a personal injury car
accident or lost a loved one in a manner which involved:
• Speeding
• Hit and run
• Rear-end crash
• Texting and driving
• Falling asleep at the wheel
• Tractor trailer negligence
• Driving while intoxicated (DWI)
• Driving under the influence (DUI)
• Pedestrian and Bicycling impact
John W. Greenway has represented clients in Austin, Texas and its
surrounding communities with effective litigation strategies and fool
proof legal tactics since 1993. His practice primarily focuses on
personal injury law to legally assist victims of negligence.
is an car accident lawyer Austin who leaves no stone unturned and is
always one step ahead of the defendant's legal team. Your best interests
are always a priority, reinforced by an elaborately-designed legal
strategy. Discover how The Greenway Law Firm in Austin, Texas can help
you. Schedule a free consultation with an car accident lawyer Austin
today at (512) 829-1213.
Wal-Mart Offering Checking Accounts – What it means to credit unions? We have a panel discussion with some of our "The Social Build" community members from around the credit union industry.
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CPACG strives
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Need a new Nashville CPA for your business, or need a
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The Reliance group is hosting the AGMs of four group companies. Ambani outlined the growth agenda for the group's non-banking financial arm – Reliance Capital – making it clear that the group…
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Although Hong Kong's tycoons have largely been opposed to Occupy Central, one finance group is openly supporting civil disobedience. The WSJ's Deborah Kan speaks to Edward Chin, founder of…
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The same advantages that make BYOD (Bring Your Own Device) popular in the workplace also sound very attractive for events – you don't have to worry about everyone have a mobile device (because everyone will have their own anyway) and your company can save the money it would take to ensure that the right devices are supplied at the right times. But BYOD also comes with its own set of challenges, and every event planning team should be aware of them while making event decisions. Here's what you should know.
BYOD Events Work with BYOD Companies
If your company already has BYOD policies, then BYOD is also a potentially effective option for your event. However, if you have corporate mobile devices that are issued to employees, there's no reason to offer BYOD – you're just creating unnecessary work and confusion. If your company doesn't have much of a mobile policy at all, you can offer BYOD, but it will take a lot of hard work to properly incorporate the right mobile strategies into your event. Think about your current BYOD situation first.
Compatibility Will Be a Challenge
There's a large and still-growing field of event apps to use today, from augmented reality apps to experience certain presentations to guest list and seating apps that allow people to sign up and navigate an event properly. However, as you have probably experienced on your own phone, not all apps are compatible with all platforms. Even the divide between iOS and Android can have a profound impact on what event apps are feasible, and that's not considering the age of phones, the uncertainty of updates, the outliers like Blackberries, and so on. You can still use event apps, but you need to make sure they have universal compatibility, which can be difficult to find. Make sure you always let attendees know about the app requirements!
BYOD Works Best When Mobile Is a Central Focus
If you are asking people to bring along their mobile devices, then you need to have ways for them to use those devices to interact and learn – otherwise, everyone just has a distraction waiting in their pocket. Make sure you have a purpose in specifying a BYOD environment. Otherwise, why call attention to it?
The BYOD Event Policy Needs to Be Published Ahead of Time
The policy for your event should be tailored to its specific concerns – you can't just copy over your company's BYOD policy (although referencing it is a good idea). BYOD policies on charging phones, using phones, making downloads and exchanging information should all be clear. Focus on security and usability, while making sure everyone knows what is expected of them when it comes to courtesy, too.
Bandwidth Will Be a Primary Concern
All those mobile devices will need a whole lot of internet access to function correctly. You want a venue with wireless bandwidth that can handle at least one device per attendee if you have a BYOD focus.
Provide Digital Downloads Afterward
With so many platforms and event apps floating around in a BYOD environment, one of the more effective ways to spread information is to provide content that works with all devices. This includes downloadable PDFs, basic links to optimized websites, and similar solutions.
For more information on how to prepare for mobile devices and what BYOD decisions to make, head over to Fourth Wall Events and let us know your goals!


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Shops and DrugstoresPrint
RANEPA bookshops are located on the first floors of academic blocks 1 and 5.
They offer a broad range of contemporary books from more than 30 leading Russian publishers. These include business literature and textbooks on finance, management, marketing, economics, psychology, sociology, law, foreign languages, history, journalism, information technologies, fiction and much more.
RANEPA shops also offer a broad selection of audiobooks, multimedia and e-textbooks, regulatory literature, stationery, office supplies, and souvenirs. They offer a cozy atmosphere with knowledgeable and helpful staff.
Monday through Friday, 9 a.m. – 8 p.m.
Saturday, 9 a.m. – 6 p.m.
Sunday – closed
Souvenirs and Accessories
A shop of stylish accessories is located on the first floor of Block 5, which sells such items including gift cards, hairclips, fashion jewelry, scarves, stoles, headwear, umbrellas, and leather goods, such as bags, belts, and gloves.
Monday through Saturday, 11 a.m. – 7 p.m.
Sunday – closed
The bakery in Block 1 sells bread and fresh baked goods.
Monday, 11:30 a.m. – 5 p.m.
Tuesday through Friday, 9 a.m. – 11 a.m., 11:30 a.m. – 5 p.m.
Saturday and Sunday – closed.
There is an optician's shop on the first floor of Block 1.
Monday through Friday, 10 a.m. – 6 p.m.
Saturday and Sunday – closed.
There is a pharmacy on the first floor of Block 5 and another on the second floor of Block 1. They sell over-the-counter drugs, health and beauty goods, medicinal herbs, health foods and cosmetics.
Hours of pharmacy in Block 1:
Monday through Friday, 8:30 a.m. – 3:45 p.m., closed from 11:45 a.m. to noon.
Saturday and Sunday – closed.
Hours of pharmacy in Block 5:
Monday thorugh Friday, 10 a.m. – 7 p.m., closed from 4 to 4:30 p.m.
Saturday, 10 am – 4 p.m.
Sunday – closed


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What does fact checked mean?
At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- National Digestive Diseases Information Clearinghouse; Celiac Disease; September 2008
- MayoClinic.com; Gluten-Free Diet; January 2010
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
What Can I Eat if I'm Allergic to Wheat & Corn?
Food allergies can be annoying at best, or potentially lethal at worst. If you are allergic to two of the most common ingredients in the American diet, it may seem like you're stuck with eating steak and vegetables for the rest of your life. The good news is the the rise in food allergy awareness has made more alternatives available. You may have to learn a few new recipes and bring your reading glasses to the grocery store, but living without wheat and corn is easier than you think.
Baked Goods
Manufacturers have made more non-wheat flours and alternative baked goods available. While wheat, rye, semolina, spelt and graham flour are off-limits to you, many baked goods can be successful with alternatives like rice flour, potato starch, tapioca flour, coconut flour and bean flour. Most larger health food stores carry these products, but regular grocery stores carry breads made without wheat if you prefer not to make your own. Look for baked goods labeled "gluten-free," and check the ingredients label for corn 2.
Most boxed cereals are problematic because they are made with either wheat or corn. There are exceptions though, like puffed rice or millet and oat-based cereals. Oatmeal is a smart breakfast option for those with wheat and corn allergies because it provides a healthy dose of fiber. Experiment a little and try unfamiliar cereals like arrowroot or tapioca, or make potato pancakes with an alternative flour. Steer clear of grits and farina, which contain corn and wheat, respectively.
Side Dishes
Dinner is when you may feel the least put-out by your diet restriction. You can't have regular pasta, but you can have tofu noodles from the produce section at the grocery store. You can still have potatoes, rice and beans, but avoid polenta, corn tortillas and cornbread. You can buy wheat-free dinner rolls in many health foods stores, or make your own from an alternative flour. Read labels carefully, because wheat and corn crop up where you least expect it -- many sauces and gravies contain cornstarch, and bouillon cubes, rice mixes and sausages can contain wheat.
Most beer is made from wheat and barley, but there are some microbrews made with allergies in mind. Read ingredient labels, and start with brands labeled "gluten-free." You can still have wine and most distilled liquors -- avoid whiskey and grain alcohol, which can contain wheat and corn. Be careful with flavored liqueurs and drink mixes -- some lower-end brand use high-fructose corn syrup as a sweetener. Examine all ingredients labels for signs of wheat and corn, or mix your own cocktails from fresh ingredients. True homemade sour mixes and simple syrup don't contain high-fructose corn syrup, so make your own for safer, better-tasting drinks.
- VeselovaElena/iStock/Getty Images


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On September 5th, Mayor Greg Ballard welcomed Perry Township Fire into the realm of city control. Three days later on September 8th, Perry Township Trustee Gary Coons, the driving force behind the merger, started a new job at the Department of Public Safety.
Critics charge the job is a reward, but say the deal fell short of giving Coons the top director's job he wanted.
Mayor Ballard tells 13 Investigates he never made any such promise for the top safety post.
"We just don't do that sort of thing. It's my decision," Ballard said. But the mayor also had good words for Coons. "He's a good man. Understand, he did a very courageous thing down there when as a trustee he said, 'Yes, I think my fire department has to go into IFD.'"
Coons says he did in fact apply for the public safety director post, but says the offer as a liaison in the department was too good to pass up. His duties: to negotiate future mergers, plan for special events including the Super Bowl, and acquire federal grants. It's a job that comes with an annual salary of $64,000.
13 Investigates asked Coons, "Was there a back room deal for you to move into this if you did XYZ or were you promised anything from the city?"
Coons responded, "I was never promised and there was never a back room deal."
The public safety job is in addition to the $51,000 he already earns providing poor relief as the Perry Township Trustee.
"What I do is, I go there in the evening or early morning and then I go in on weekends. I don't think I should earn a full time salary by no means," Coons said, explaining how he juggles the workload.
Not surprisingly, Coons shamelessly uses the fact that he suffers from Parkinson's Disease as a deflection to his self-dealing. Mayor Ballard insisted that no deal was made with Coons, but his explanation simply rings hollow. Why else would Coons land a job just days after the merger deal was approved if there wasn't a quid pro quo?