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Journal Articles
The Journal of General Physiology (2019) 152 (1): e201912455.
Published: 24 December 2019
All cells must control the activities of their ion channels and transporters to maintain physiologically appropriate gradients of solutes and ions. The complexity of underlying regulatory mechanisms is staggering, as exemplified by insulin regulation of transporter trafficking. Simpler strategies occur in single-cell organisms, where subsets of transporters act as solute sensors to regulate expression of their active homologues. This Viewpoint highlights still simpler mechanisms by which Na transporters use their own transport sites as sensors for regulation. The underlying principle is inherent to Na/K pumps in which aspartate phosphorylation and dephosphorylation are controlled by occupation of transport sites for Na and K, respectively. By this same principle, Na binding to transport sites can control intrinsic inactivation reactions that are in turn modified by extrinsic signaling factors. Cardiac Na/Ca exchangers (NCX1s) and Na/K pumps are the best examples. Inactivation of NCX1 occurs when cytoplasmic Na sites are fully occupied and is regulated by lipid signaling. Inactivation of cardiac Na/K pumps occurs when cytoplasmic Na-binding sites are not fully occupied, and inactivation is in turn regulated by Ca signaling. Potentially, Na/H exchangers (NHEs) and epithelial Na channels (ENaCs) are regulated similarly. Extracellular protons and cytoplasmic Na ions oppose secondary activation of NHEs by cytoplasmic protons. ENaCs undergo inactivation as cytoplasmic Na rises, and small diffusible molecules of an unidentified nature are likely involved. Multiple other ion channels have recently been shown to be regulated by transiting ions, thereby underscoring that ion permeation and channel gating need not be independent processes.
Includes: Supplementary data
Journal Articles
The Journal of General Physiology (2019) 151 (11): 1265–1271.
Published: 30 September 2019
In a recent JGP article, Heeley et al. (2019. J. Gen. Physiol . https://doi.org/10.1085/jgp.201812198 ) reopened the debate about two- versus three-state models of thin filament regulation. The authors review their work, which measures the rate constant of P i release from myosin.ADP.Pi activated by actin or thin filaments under a variety of conditions. They conclude that their data can be described by a two-state model and raise doubts about the generally accepted three-state model as originally formulated by McKillop and Geeves (1993. Biophys. J. https://doi.org/10.1016/S0006-3495(93)81110-X ). However, in the following article, we follow Plato's dictum that "twice and thrice over, as they say, good it is to repeat and review what is good." We have therefore reviewed the evidence for the three- and two-state models and present our view that the evidence is overwhelmingly in favor of three structural states of the thin filament, which regulate access of myosin to its binding sites on actin and, hence, muscle contractility.
Journal Articles
The Journal of General Physiology (2019) 151 (7): 878–886.
Published: 30 May 2019
The lactose permease (LacY) of Escherichia coli is the prototype of the major facilitator superfamily, one of the largest families of membrane transport proteins. Structurally, two pseudo-symmetrical six-helix bundles surround a large internal aqueous cavity. Single binding sites for galactoside and H + are positioned at the approximate center of LacY halfway through the membrane at the apex of the internal cavity. These features enable LacY to function by an alternating-access mechanism that can catalyze galactoside/H + symport in either direction across the cytoplasmic membrane. The H + -binding site is fully protonated under physiological conditions, and subsequent sugar binding causes transition of the ternary complex to an occluded intermediate that can open to either side of the membrane. We review the structural and functional evidence that has provided new insight into the mechanism by which LacY achieves active transport against a concentration gradient.
Journal Articles
Investigation into the mechanism of thin filament regulation by transient kinetics and equilibrium binding: Is there a conflict?
The Journal of General Physiology (2019) 151 (5): 628–634.
Published: 01 March 2019
Striated muscle contraction occurs when myosin undergoes a lever-type structural change. This process (the power stroke) requires ATP and is governed by the thin filament, a complex of actin, tropomyosin, and troponin. The authors have used a fast-mixing instrument to investigate the mechanism of regulation. Such (pre–steady-state kinetic) experiments allow biochemical intermediates in a working actomyosin cycle to be monitored. The regulatory focal point is demonstrated to be the step that involves the departure of inorganic phosphate (i.e., AM-ADP-Pi → AM-ADP). This part of the cycle, which lies on the main kinetic pathway and coincides with the drive stroke, is maximally accelerated ∼100-fold by the combined association of ligands (Ca[II] and rigor myosin heads) with the thin filament. However, the observed ligand dependencies of the rates of Pi dissociation that are reported herein are at variance with predictions of models derived from experiments where ATP hydrolysis is not taking place (and myosin exists in a nonphysiological form). It is concluded that the principal influence of the thin filament is in setting the rate of Pi dissociation and that physiological levels of regulation are dependent upon the liganded state of the thin filament as well as the conformation of myosin.
Journal Articles
The Journal of General Physiology (2018) 150 (12): 1640–1646.
Published: 23 November 2018
Journal Articles
The Journal of General Physiology (2018) 150 (10): 1360–1372.
Published: 06 September 2018
Recent breakthroughs and developments in structural biology have led to a spate of crystal structures for G protein–coupled receptors (GPCRs). This is the case for the muscarinic acetylcholine receptors (mAChRs) where inactive-state structures for four of the five subtypes and two active-state structures for one subtype are available. These mAChR crystal structures have provided new insights into receptor mechanisms, dynamics, and allosteric modulation. This is highly relevant to the mAChRs given that these receptors are an exemplar model system for the study of GPCR allostery. Allosteric mechanisms of the mAChRs are predominantly consistent with a two-state model, albeit with some notable recent exceptions. Herein, we discuss the mechanisms for positive and negative allosteric modulation at the mAChRs and compare and contrast these to evidence offered by pharmacological, biochemical, and computational approaches. This analysis provides insight into the fundamental pharmacological properties exhibited by GPCR allosteric modulators, such as enhanced subtype selectivity, probe dependence, and biased modulation while highlighting the current challenges that remain. Though complex, enhanced molecular understanding of allosteric mechanisms will have considerable influence on our understanding of GPCR activation and signaling and development of therapeutic interventions.
Journal Articles
The Journal of General Physiology (2018) 150 (5): 671–682.
Published: 17 April 2018
The H + -coupled vesicular monoamine transporter (VMAT) is a transporter essential for life. VMAT mediates packaging of the monoamines serotonin, dopamine, norepinephrine, and histamine from the neuronal cytoplasm into presynaptic vesicles, which is a key step in the regulated release of neurotransmitters. However, a detailed understanding of the mechanism of VMAT function has been limited by the lack of availability of high-resolution structural data. In recent years, a series of studies guided by homology models has revealed significant insights into VMAT function, identifying residues that contribute to the binding site and to specific steps in the transport cycle. Moreover, to characterize the conformational transitions that occur upon binding of the substrate and coupling ion, we have taken advantage of the unique and powerful pharmacology of VMAT as well as of mutants that affect the conformational equilibrium of the protein and shift it toward defined conformations. This has allowed us to identify an important role for the proton gradient in driving a shift from lumen-facing to cytoplasm-facing conformations.
Journal Articles
The Journal of General Physiology (2017) 150 (1): 19–39.
Published: 12 December 2017
Pannexin 1 (Panx1) forms plasma membrane ion channels that are widely expressed throughout the body. Panx1 activation results in the release of nucleotides such as adenosine triphosphate and uridine triphosphate. Thus, these channels have been implicated in diverse physiological and pathological functions associated with purinergic signaling, such as apoptotic cell clearance, blood pressure regulation, neuropathic pain, and excitotoxicity. In light of this, substantial attention has been directed to understanding the mechanisms that regulate Panx1 channel expression and activation. Here we review accumulated evidence for the various activation mechanisms described for Panx1 channels and, where possible, the unitary channel properties associated with those forms of activation. We also emphasize current limitations in studying Panx1 channel function and propose potential directions to clarify the exciting and expanding roles of Panx1 channels.
Journal Articles
The Journal of General Physiology (2017) 149 (12): 1091–1103.
Published: 31 October 2017
Crystal structures provide visual models of biological macromolecules, which are widely used to interpret data from functional studies and generate new mechanistic hypotheses. Because the quality of the collected x-ray diffraction data directly affects the reliability of the structural model, it is essential that the limitations of the models are carefully taken into account when making interpretations. Here we use the available crystal structures of members of the glutamate transporter family to illustrate the importance of inspecting the data that underlie the structural models. Crystal structures of glutamate transporters in multiple different conformations have been solved, but most structures were determined at relatively low resolution, with deposited models based on crystallographic data of moderate quality. We use these examples to demonstrate the extent to which mechanistic interpretations can be made safely.
Journal Articles
The Journal of General Physiology (2017) 149 (6): 613–622.
Published: 18 May 2017
Voltage-gated sodium channels enable the translocation of sodium ions across cell membranes and play crucial roles in electrical signaling by initiating the action potential. In humans, mutations in sodium channels give rise to several neurological and cardiovascular diseases, and hence they are targets for pharmaceutical drug developments. Prokaryotic sodium channel crystal structures have provided detailed views of sodium channels, which by homology have suggested potentially important functionally related structural features in human sodium channels. A new crystal structure of a full-length prokaryotic channel, NavMs, in a conformation we proposed to represent the open, activated state, has revealed a novel interaction motif associated with channel opening. This motif is associated with disease when mutated in human sodium channels and plays an important and dynamic role in our new model for channel activation.
Includes: Supplementary data
Journal Articles
The Journal of General Physiology (2016) 149 (1): 37–47.
Published: 20 December 2016
Mammalian cilia are ubiquitous appendages found on the apical surface of cells. Primary and motile cilia are distinct in both morphology and function. Most cells have a solitary primary cilium (9+0), which lacks the central microtubule doublet characteristic of motile cilia (9+2). The immotile primary cilia house unique signaling components and sequester several important transcription factors. In contrast, motile cilia commonly extend into the lumen of respiratory airways, fallopian tubes, and brain ventricles to move their contents and/or produce gradients. In this review, we focus on the composition of putative ion channels found in both types of cilia and in the periciliary membrane and discuss their proposed functions. Our discussion does not cover specialized cilia in photoreceptor or olfactory cells, which express many more ion channels.
Journal Articles
The Journal of General Physiology (2016) 148 (4): 277–291.
Published: 12 September 2016
Ion channels are membrane proteins that mediate efficient ion transport across the hydrophobic core of cell membranes, an unlikely process in their absence. K + channels discriminate K + over cations with similar radii with extraordinary selectivity and display a wide diversity of ion transport rates, covering differences of two orders of magnitude in unitary conductance. The pore domains of large- and small-conductance K + channels share a general architectural design comprising a conserved narrow selectivity filter, which forms intimate interactions with permeant ions, flanked by two wider vestibules toward the internal and external openings. In large-conductance K + channels, the inner vestibule is wide, whereas in small-conductance channels it is narrow. Here we raise the idea that the physical dimensions of the hydrophobic internal vestibule limit ion transport in K + channels, accounting for their diversity in unitary conductance.
Journal Articles
The Journal of General Physiology (2016) 148 (3): 183–193.
Published: 29 August 2016
Studies in the literature describe the ability of dietary supplementation by omega-3 fish oil to increase the pumping efficiency of the left ventricle. Here we attempt to reconcile such studies with our own null results. We undertake a quantitative analysis of the improvement that could be expected theoretically, subject to physiological constraints, by posing the following question: By how much could efficiency be expected to increase if inefficiencies could be eliminated? Our approach utilizes thermodynamic analyses to investigate the contributions, both singly and collectively, of the major components of cardiac energetics to total cardiac efficiency. We conclude that it is unlikely that fish oils could achieve the required diminution of inefficiencies without greatly compromising cardiac performance.
Journal Articles
The Journal of General Physiology (2015) 145 (6): 459–474.
Published: 25 May 2015
A novel category of diseases of striated muscle is proposed, the couplonopathies, as those that affect components of the couplon and thereby alter its operation. Couplons are the functional units of intracellular calcium release in excitation–contraction coupling. They comprise dihydropyridine receptors, ryanodine receptors (Ca 2+ release channels), and a growing list of ancillary proteins whose alteration may lead to disease. Within a generally similar plan, the couplons of skeletal and cardiac muscle show, in a few places, marked structural divergence associated with critical differences in the mechanisms whereby they fulfill their signaling role. Most important among these are the presence of a mechanical or allosteric communication between voltage sensors and Ca 2+ release channels, exclusive to the skeletal couplon, and the smaller capacity of the Ca stores in cardiac muscle, which results in greater swings of store concentration during physiological function. Consideration of these structural and functional differences affords insights into the pathogenesis of several couplonopathies. The exclusive mechanical connection of the skeletal couplon explains differences in pathogenesis between malignant hyperthermia (MH) and catecholaminergic polymorphic ventricular tachycardia (CPVT), conditions most commonly caused by mutations in homologous regions of the skeletal and cardiac Ca 2+ release channels. Based on mechanistic considerations applicable to both couplons, we identify the plasmalemma as a site of secondary modifications, typically an increase in store-operated calcium entry, that are relevant in MH pathogenesis. Similar considerations help explain the different consequences that mutations in triadin and calsequestrin have in these two tissues. As more information is gathered on the composition of cardiac and skeletal couplons, this comparative and mechanistic approach to couplonopathies should be useful to understand pathogenesis, clarify diagnosis, and propose tissue-specific drug development.
Journal Articles
The Journal of General Physiology (2013) 142 (6): 575–578.
Published: 11 November 2013
The voltage dependence of charges in voltage-sensitive proteins, typically displayed as charge versus voltage ( Q-V ) curves, is often quantified by fitting it to a simple two-state Boltzmann function. This procedure overlooks the fact that the fitted parameters, including the total charge, may be incorrect if the charge is moving in multiple steps. We present here the derivation of a general formulation for Q-V curves from multistate sequential models, including the case of infinite number of states. We demonstrate that the commonly used method to estimate the charge per molecule using a simple Boltzmann fit is not only inadequate, but in most cases, it underestimates the moving charge times the fraction of the field.
Journal Articles
The Journal of General Physiology (2013) 141 (2): 151–160.
Published: 14 January 2013
Journal Articles
An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations
Ernesto Vargas, Vladimir Yarov-Yarovoy, Fatemeh Khalili-Araghi, William A. Catterall, Michael L. Klein ...
The Journal of General Physiology (2012) 140 (6): 587–594.
Published: 26 November 2012
Developing an understanding of the mechanism of voltage-gated ion channels in molecular terms requires knowledge of the structure of the active and resting conformations. Although the active-state conformation is known from x-ray structures, an atomic resolution structure of a voltage-dependent ion channel in the resting state is not currently available. This has motivated various efforts at using computational modeling methods and molecular dynamics (MD) simulations to provide the missing information. A comparison of recent computational results reveals an emerging consensus on voltage-dependent gating from computational modeling and MD simulations. This progress is highlighted in the broad context of preexisting work about voltage-gated channels.
Includes: Supplementary data


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Improving Drive-in Sound
Sound is increasingly becoming a major part of the cinema experience, if drive-in theaters don't want to lose customers to the ever increasing number of multiplexes popping up all over the place, sound is something they need to take seriously.
Improve your drive-in movie theater's sound quality by installing a BW Broadcast FM Transmitter.
Over the last decade the use of 35mm and 70mm film has all but disappeared in favor of digital projection. Drive-in theaters have benefited from this advance in technology and can now offer their customers dramatically improved image quality and brightness. The number of drive-in theaters has actually increased in recent years, whilst others have been expanding. It proves that the drive-in theater business can grow and prosper, but they need to move with the times, and sound quality is going to be a major part of that.
The typical drive-in broadcasts the film soundtrack over low-power FM. Many use Part 15 FM transmitters, which are widely available, and offer a cost effective solution compared with the professional transmitters available to them. But these transmitters were designed for re-broadcasting around the home or hobbiest and don't offer the sound quality that todays discerning movie-goer expects.
West Wind Drive-Ins (the largest chain of drive-in cinemas in the U.S.) made the decision to convert all 34 screens to digital projection, they took the opportunity to upgrade all of the sound systems too.
Chris Markiewicz, Projection and Sound Technician, West Wind Drive-Ins, says:
"We have equipped all of our screens with BW Broadcast TX5 V2 transmitters. They can easily be adjusted from practically nothing, all the way to 5 watts from the front panel, this means we can turn the power up and down, enabling us to achieve exactly the right coverage for each site. They broadcast through tuned ¼ -wave ground plane antennas mounted to masts on the roofs of the projection buildings. Output of the transmitters is adjusted for a clean signal on the drive-in fields.
The digital sound systems work as follows: The sound is output from the projector as a 5.1 LPCM bitstream. It goes to the audio rack where it is converted to analog 5.1 audio via a D/A converter. It then goes through an automated mixdown to 2.0 stereo. The next step is a line-level mixer to allow for level control and EQ if needed. The signal then feeds the transmitter and antenna.
Using the BW Broadcast transmitters results in sound that is equal in quality to the local FM commercial stations. The transmitters have built-in audio processing so the sound quality is first class, there is no hum or background noise, and frequency response is good out to 15kHz. This represents a quantum leap over the sound we experienced with our older transmitters, all of which were far more expensive to purchase.
The rest of the digital projection systems consist of Barco DP2K-32B projectors, the brightest on the market at 31,000 lumens, and Doremi ShowVault servers that play back the digital content. All in all, we believe that West Wind Drive-Ins provide the best in digital projection and sound to our customers in California, Nevada and Arizona."
Not many drive-in operators know that they can change the format of the audio processing to suit the audio style of the film with the TX5. Dialogue heavy films can use talk audio processing while music heavy films can have the music sound dynamic with a pop music style preset, just like it would be on the radio. Changing the sound of the transmission to suit the film takes seconds, and can be done remotely through a web browser if required.
Jennifer Sherer, CEO of Drive-On-In Inc, says:
"For me, the drive-in conjures up images like ones in Happy Days. As our world becomes more hectic and less safe, the more the drive-in becomes a wholesome retreat from it."
But staying afloat in a niche market is no easy ride for business owners. Operators who survived the difficult years are re-investing in multiple screens and modern FM radio sound to attract new punters.
Contact our Sales Team to find out how we can help improve the sound quality of your drive-in.


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|Classical, Country, Jazz, Swing, Folk, Improvisation
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Violin teacher and academic with 30+ years of teaching across a wide range of styles including Classical, Country, Jazz, Folk and improvisational styles.
I have been teaching at the Elder Conservatorium and in Indonesia and am now offering bespoke private violin lessons tailored to meet individual learning styles, music preferences, and goals including AMEB exams, and to suit all levels and ages.
Teaching at my Bellevue Heights studio, or at student's location for an additional travel fee.
Find others who offer Adelaide Violin Lessons
Details last updated on July 27, 2019


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Home Topics Victoria Asher
Victoria Asher
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Trump's Antagonism Of Iran Is A Wrapped Gift To Bernie
Trump has elevated the Middle East wars as a major issue in 2020, not his strong suit. For, as the military says, "The enemy gets a vote!" as to how much blood, including American blood, will be shed in 2020. With the killing of the general and the possibility of a U.S.-Iran war rising, Bernie is the Democratic candidate whose anti-war credentials are the longest and strongest and whose position of avoiding war with Iran is most in sync with the majority of the party he seeks to lead. Sanders could ride anti-war sentiment to victory in Iowa and New Hampshire and have the wind behind him going into South Carolina and Super Tuesday. He could occupy in 2020 the space Trump occupied in 2016.
Iran's Airborne Chernobyl
That jetliner wasn't quite the disaster Chernobyl was, but neither is the Iranian mullahocracy the Soviet Union. It's a sleazy, illegitimate Third World thugocracy engaged in terrorism, international organized crime, and assorted dirty tricks designed to intimidate and destabilize its neighbors and others around the world, and it has been running a con game on the entire planet for the last 40 years. The mullahs have never delivered on any of their promises to the people of that country, and they're hated by the Iranian people. It's only a matter of time before the bell tolls for them. Now we'll see how long the incompetence and lies can be carried by a failed regime.
Democrats Always Choose America's Enemies Over America
Among the Democrat voters, there are patriots, including those who have served our country with honor and who continue serving today. Those Dem voters are disgusted with you and, if I was cynical, and I am totally cynical, I would issue them a heartfelt invitation to join the GOP, where people who love America are welcome. Walk away, Democrat patriots. Welcome to the GOP. Regardless, you don't take our disagreements outside of the country. You don't fight in front of foreigners. And you don't ever take the enemy's side. These are just basic, threshold requirements to call yourself a "patriot." Unless you don't want to be a patriot. Admit you are too weak to stand up for it.
Now Is The Time To Win The War With Iran
- 2020 Election
- Ayatollah Ali Khamenei
- declaration of war
- Iran
- Iraq War
- Israel
- Joint Comprehensive Plan of Action
- Kim Jong-un
- non-intervention foreign policy
- North Korea
- Nuclear Iran
- nuclear war
- Obama Iran deal
- protests
- Qasem Soleimani
- Rand Paul
- Robert O'Brien
- Trump doctrine
- Tucker Carlson
- Ukrainian crash
- war powers act
- Wiayat al-Faqih
Demonstrators have taken to the streets calling for Iranian Supreme Leader Ayatollah Ali Khamenei to step down and for those responsible for shooting down the Ukrainian jetliner killing all 176 aboard prosecuted. The weakness of Iran's system of Wilayat al-Faqih has never been more obvious and the opportunity to undermine it from within rarely greater.
Neither Neocon nor Isolationist
Trump never promised anyone he'd refuse to respond to threats to Americans, or honor the unspoken rules protecting a bloodstained high official of a hostile foreign regime. If Trump had said any of these things, it would have been out of character. The killing of Soleimani is likelier to add to the legend of Donald Trump for his most loyal backers instead of give them pause. In their view, here is President Trump once again doing what no other president would do, taking an inordinate amount of criticism for it, often from a perpetually hysterical press corps, and having it work out (so far). Killing of Soleimani was an unmistakable expression of Trump's distinctive worldview.
The Chicken Littles got everything wrong on Trump and Iran
Pelosi still believes in the fiction otherwise known as the Iranian nuke deal. They bought Barack Obama's risible claim that the deal — not a treaty — would lure Iran back into the community of nations. Obama even sweetened the pot with billions of dollars, and skirted banking rules to deliver pallets of cash to Tehran. In fact, it was quickly clear that Soleimani used much of that money to fund armed proxy groups throughout the Mideast. As Trump said Wednesday, "Iran went on a terror spree funded by the money from the deal and created hell in Yemen, Syria, Lebanon, Afghanistan and Iraq." That blood money is part of what Pelosi wants to protect with her war powers resolution on Iran.
Nancy Pelosi gives bizarre, inappropriate press conference after plane crash
Speaker Pelosi is terrifying when she gets down to business. Mrs. Pelosi's legislation was aimed at Mr. Trump. In all of the gravity and terror of the past week, Mrs. Pelosi's only urgent response is to constrain the American president against Iran and the terrorists who chant, "Death to America!" "The administration conducted a provocative, disproportionate airstrike against Iran, which endangered Americans and did so without informing Congress," she sniffed. What, precisely, would have been a more proportionate response for a terrorist plotting to kill American troops and diplomats Mrs. Pelosi did not say. She was off to celebrate the wedding of Barbara Lee.
It's war with Iran. Is America in it to win it?
Iran's theocratic leadership believes war is the path to revealing the "12th Imam," their version of the Christian second coming. The mullahs of Iran are true believers who it appears are willing, even eager, to die for their cause, or more accurately have others die in their place. Iran and its proxies kill U.S. troops, along with Iranian and foreign civilians and we are supposed to take it. If America responds to Iran, as President Trump has done (unlike Obama and Clinton), we are the enemy of peace and guilty of "escalating" the conflict. War is never a one-way street, unless one side pre-emptively surrenders. Victory must be our goal and should be defined.
Iran's Options in a Showdown with America Are All Bad
Constant provocation is a not a good alternative, but it's probably seen as preferable to the other poor choices. The strategic aim in such endless tit-for-tat would be to wear down the patience of the U.S. public in an election year. Iran's goal might be something like re-creating the melodrama of the 1979–81 hostage crisis, Saddam Hussein's rope-a-dope strategy, or Bill Clinton's three-month bombing campaign in Yugoslavia. Tehran hopes for American strategic ossification that could prove politically toxic. But that scenario, too, is unlikely. As long as Trump replies with air power disproportionate to any Iranian attacks, he, not Tehran, governs the tempo of the confrontation.
Conservatives Split On War Powers
- 2020 Election
- declaration of war
- declaring war
- Iran
- Iraq War
- Israel
- Joint Comprehensive Plan of Action
- Kim Jong-un
- Mike Pence
- non-intervention foreign policy
- North Korea
- Nuclear Iran
- nuclear war
- Obama Iran deal
- Qasem Soleimani
- Rand Paul
- Robert O'Brien
- Sen. Lindsey Graham
- Sen. Mike Lee
- Sen. Rand Paul
- Trump doctrine
- Tucker Carlson
- war powers act
We are inclined to agree that raising the war powers issue at this time gives aid and comfort to the enemy – but the enemy in question is not Iran, it is the Democrats who want only to make points with their Trump-hating base and render President Trump impotent in the face of Iranian threats and aggression.
Our Unpatriotic Press Coddles Dictators
There's nothing wrong with skeptical questions of our government. But why is it impossible to celebrate blowing up the man responsible for the deaths of untold thousands? And why do the media so often fail to muster that same sort of skeptical questioning for the tyrants and thugs opposing American interests? Theirs is a long, sordid history of offering unchallenged platforms, and even buttery sympathy, to our enemies. If our press were truly patriotic, they would question our tyrannical enemies at least as skeptically as they question our own elected leaders. Instead, they're so hungry for access, for a big "get," that they sound like butlers and maids of the world's worst thugs.
Trump didn't make Iran's rulers killers, but Obama did enable them
The Iran deal was not disastrous merely because Obama accepted a ludicrously weak inspections protocol, although he did. It was awful because it still enabled the regime to become a more powerful conventional threat by providing the mullahs with the money to pursue terrorism and the freedom to develop ballistic missiles. Furthermore, restrictions imposed by the deal would have started to sunset after 10 years, meaning the terror state still maintained its long-term ability to develop nuclear weapons. The Obama administration and its allies are attempting to blame Trump for bad Iranian behavior to distract people from recognizing the failed legacy of the deal.
Sorry Democrats, There Is A Trump Doctrine, And It's A Good One
Despite what the Democrats and their media allies want Americans to believe about President Trump and his foreign policy, Trump has been remarkably consistent in his approach to rogue states, such as North Korea and Iran. And the Trump doctrine makes a lot more sense than sending them pallets of cash or refusing to engage with them and pretending they are not there.
Soleimani dead, but 'America First' very much alive
We are deeply entangled in Iraq, a place Mr. Trump and many Americans would dearly like to depart. Along comes Iran, which launches an attack on our embassy compound in Baghdad, ordered by this thug Soleimani. What on God's green Earth is Mr. Trump supposed to do in response to such an attack? Write a check for more than $1 billion and give it to the mullahs? Send a plane under the cover of darkness carrying pallets of $400 million in unmarked cash for the ayatollah? Wipe out effective sanctions so that Soleimani might sow even more terrorism around the world? Well, that is precisely what the previous administration did. But not Mr. Trump. Instead, he killed the thug.
Could The Confrontation With Iran Go Nuclear?
The most important thing to come out in the post-Soleimani statements from the White House was this comment from National Security Advisor Robert O'Brien: "I think the President made it very clear that Iran will not have a nuclear weapon and I think we have got a lot of friends and allies both in the region and in Europe who are committed to that outcome."
How Tucker And Rand Got It Wrong On Killing Soleimani
As we have explained on numerous occasions Iran has declared war on America and the West, so whether we wish it, or not, we are in a war with the Islamic Republic, and whether we wish it, or not, one of the principle battlefields in that war is Iraq, where, until President Trump took him out, Qasem Soleimani was directing operations against us with impunity.
Biden Wrong On Foreign Policy And Lying About It (Again)
As former Secretary of Defense Robert Gates once said, Joe Biden has been "wrong on nearly every major foreign policy and national security issue over the past four decades." Now Biden is lying and trying to rewrite history to cover up those miscalculations and failures in judgement. Here are six recent lies about foreign policy from Joe Biden.
Iranian Analytics
A weaker Iran foolishly positioned itself into the role of aggressor, at a time of a shot economy, eroding military strength, waning terrorist appendages abroad, and little political leverage or wider support. China and Russia are confined to hoping the U.S. is somehow, somewhere bogged down. Europe will still lecture on the fallout from canceling the Iran Deal, but quietly welcomes the fact that Iran is weaker than in 2015 and weaker for them is far better. The current Iranian crisis is complex and dangerous. And by all means retaliation must be designed to prevent more Iranian violence and aggression rather than aimed at a grandiose agenda of regime change or national liberation. But so far the Iranians, not the U.S., are making all the blunders.
Killing Soleimani Was The Right Move, And Shows Precisely Why It's Time To Leave Iraq
Rather than ask how to whip Iran, we should be wondering if our blood and treasure is better served in defending against the real threats to our homeland. Unending American war in the Middle East drains our coffers, military strength, and political will, all to the glory of Moscow and our true enemies in Beijing. Meanwhile, foreign policy hawks in Washington are terrified Russia might follow our lead, as they have in Syria. Since his inauguration, President Donald Trump has killed the leader of ISIS, and now the Iranian general responsible for hundreds of American dead. He's done a great deal to clean up the mess his predecessors left him in Iraq and Syria. Now it is time to disengage.
Jaw-Jaw or War With Iran?
France, Britain and Germany, co-signers of the nuclear deal who have sought to maintain the agreement, now appear to believe the Iranians are violating the spirit if not the letter of the deal by testing nuclear-capable ballistic missiles. Iranian Foreign Minister Javad Zarif calls the allegation "a desperate falsehood." The Europeans are "bowing to US bullying," and covering up their own "miserable incompetence," he said. Two U.S. Defense Secretaries, Leon Panetta and James Mattis, called this weekend for U.S.-Iranian negotiations. And Trump's tweet on the prisoner exchange indicates a receptivity to the idea. For all involved, jaw-jaw would seem a better option than war-war.


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Summertimes in Golden Beach can be sweltering! We all understand exactly how hard it is to rest, work, or play while you're suffering in the sweltering heat. No person intends to breathe thick, hot air in their own home. If you reside in Golden Beach, call us for prompt and efficient air conditioning repair.
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This lecture examines the work of Hugo de Vries, a Dutch botanist who was one of the first to claim that science would allow plants and animals to be designed to order.
It also looks at the early twentieth-century 'Station for Experimental Evolution' in New York, and at the utopian vision of Charlotte Gilman Perkins' Herland (1915), a novel describing a lost world populated by women that took the form of a perfect garden, whose wonderful plants and lack of men were both explained by de Vries' theory of mutation.
No reservations are required for this lecture. It will be run on a 'first come, first served' basis.
Doors will open 30 minutes before the start of the lecture
Jim is Professor of the History of Science at the University of Sussex. He specialises from Victorian natural history to the modern genetics and has presented programmes for BBC Radio 4.
Professor Endersby's lecture series are as follows:
2019/20 Utopian Gardens
All lectures by the Visiting Professor in the History of Science can be accessed here.
Current Visiting Professor of Environment


text: Football International International Sneijder admits Netherlands' glory days are over The Dutch made it to the final at the 2010 World Cup, while reaching the semi-finals in Brazil four years later. Stefan Coerts 09 November, 2016 21:56 IST Wesley Sneijder playing for Netherlands. Stefan Coerts 09 November, 2016 21:56 IST Wesley Sneijder has admitted Netherlands is no longer the major force in international football it once was. The Dutch made it to the final at the 2010 World Cup, while reaching the semi-finals in Brazil four years later. The team failed to qualify for Euro 2016, though, and have struggled in the early stages of the 2018 World Cup qualification, too. "We are no longer driving toward the stadium knowing that we will win and that we are just wondering by what margin we will win," Sneijder told Metro. Those days are over and I miss that feeling. "I hope that we can create a similar era in the future, even if I will not be part of it. This group of players has the potential and quality to reach that same level," said Sneijder. Netherlands had to settle for a 1-1 draw with Sweden in their Group A opener, before beating Belarus 4-1 and then losing 1-0 at home to France in October. They subsequently occupy third place in the table heading into their November internationals, but Sneijder feels they have just been unlucky. "We deserved three points against Sweden and I think a draw would have been a fair result against France," he added. "I really think we did not do a bad job." Netherlands takes on Belgium in a friendly on Wednesday, before facing Luxembourg on Sunday in its fourth World Cup qualifying match. Subscribe to our daily newsletter Get your daily dose of Sportstar with handpicked stories delivered right to your inbox! SUBSCRIBE Please enter a valid email address. Dugout videos


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- Price$1,900,000
- Beds7
- Baths9
- SQ. Feet5,761
- Acres1.00
- Built2007
685 Morel Ct, St Albans
TRULY MUST BE SEEN! Breathtaking 1.5 story home on 1+ secluded acres w/ attention to detail around every corner. An entertainer's dream! 7 Bedrms – ML master, 3 UL, 2 in the walk-out LL, 1 above garage & 8.5 baths. Kitchen features Sub-Zero refrigerator, Wolf gas stove, 2 dishwashers, custom copper sink, extra-large granite island & large walk-in pantry. ML custom antique wet bar w/ copper top & wine cellar. Great rm w/ a custom barn wood accent wall. Play/craft rm w/ mini kitchen. Private entrance office/bedrm above 2 car garage. 3 laundry hook-ups – UL & 2 ML. Awesome outdoor area w/ In-ground custom pool w/ slide, bar/porch area w/ retractable screen & playground area. Addtl features include - 5 fireplaces, Hunter Douglass shutters, Insta-heat water circulating system for kitchen & UL, Culligan Water softer, large hidden safe, tons of storage, gas lanterns on front porch, 5 car (climate controlled) garage, newer roof ('15), 2 new water heaters ('19), aggregated circle drive & more!
Essential Information
- Price$1,900,000
- Bedrooms7
- Bathrooms9.00
- Full Baths8
- Half Baths1
- Square Footage5,761
- Acres1.00
- Year Built2007
- TypeResidential
- StyleOther
- StatusActive
- Basement TypeBathroom in LL, Fireplace in LL, Partially Finished, Poured Concrete, Rec/Family Area, Sleeping Area, Walk-Out
- Taxes$11,669
- AmenitiesClub-Golf, Clubhouse/Facilities, Private Inground Pool
- FeaturesDeck, Patio, Covered Porch, Burglar Alarm-Owned, In-Ground Sprklr Sys
- Parking Spaces5
- ParkingAttached Garage, Detached, Garage Door Opener
- # of Garages5
- Garages-
- Community Pool & Private PoolYes
- Lot DescriptionBacks to Trees/Woods, Fencing
- WindowsFrench Door(s), Some Insulated Wndws, Panel Door(s)
- ConstructionBrk/Stn Veneer Frnt
Additional Information
- Date ListedJuly 17th, 2019
- Days on Market184
- HOA Fees1900
- HOA Fees Freq.Yearly
Community Information
- Address685 Morel Ct
- AreaWashington School
- SubdivisionCedars Valley
- CitySt Albans
- CountyFranklin
- StateMO
- Zip Code63073
- InteriorOpen Floor Plan, Some Carpeting, Special Millwork, Some Window Treatmnt, Vaulted Ceiling, Walk-In Closets, Wetbar, Some Wood Floors
- AppliancesDishwasher, Disposal, Gas Cooktop, Refrigerator, Range Hood, Stainless Steel Appliances
- HeatingForced Air, Zoned
- CoolingCeiling Fan, Central-Electric, Zoned
- Has BasementYes
- BasementBathroom in LL, Fireplace in LL, Partially Finished, Poured Concrete, Rec/Family Area, Sleeping Area, Walk-Out
- FireplaceYes
- # of Fireplaces4
- FireplacesGas
- Stories1.5 Story
School Information
- DistrictWashington
- ElementaryLabadie Elem.
- MiddleWashington Middle
- HighWashington High
Listing Details
- Listing OfficeBerkshire Hathaway Alliance
Information from Third Parties, Deemed Reliable but Not Verified.
Listings displaying the MARIS logo are courtesy of Mid America Regional Information Systems Internet Data Exchange.


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Internationally recognized writer and poet to be Richmond's 2019 Writer-in-Residence
23 September 2019
The City of Richmond is pleased to announce that poet and author Cynthia Sharp is the City's 2019 Writer-in-Residence. Throughout this October and November, Cynthia will provide advice to aspiring local writers through a unique blend of public workshops, events and conversations.
Now in its eighth year, Richmond's Writer-in-Residence program will kick off with an informal Meet and Greet on Tuesday, October 1 from 1 to 3 p.m. at the Minoru Centre for Active Living, located at 7191 Granville Avenue. This free, public event is an opportunity for community members to meet Cynthia and learn about the programming she will be offering.
Cynthia's writing work has been featured in international literary publications with regular performances at literary festivals and gatherings across BC. During her residency, she will lead a series of unique workshops on flash fiction, screen writing and sensory writing. She will also be at Richmond Public Library's Brighouse Branch every Sunday afternoon over the two months for drop-in conversations with interested readers and writers.
This year's residency will culminate in a final celebration on Saturday, November 23 from 2 to 4 p.m. in the Richmond Cultural Centre Performance Hall, located at 7700 Minoru Gate.
Richmond's Writer-in-Residence program is a partnership residence at the Minoru Place Activity Centre, Richmond Arts Centre and Richmond Public Library. Details about the residency program and the workshops that will be offered are available at www.richmond.ca/writerinresidence.


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There is no better way to see everything Terre Haute has to offer than by getting behind the wheel of your Budget rental car. Stop spending your vacation waiting on the bus, or being nickel and dimed with ride-shares or taxis. When you have access to your own vehicle, you can drive wherever you want to go, when you want. Make your next getaway to Indiana even more enjoyable with a Budget car rental.
CarRentals.com takes care of all the speed bumps
Terre Haute is a perfect destination when you need a break from rat race of a big city. Many guests come to enjoy Terre Haute's thriving art scene. Whatever you decide on first, you'll want to take in as much of Terre Haute as possible while on your trip. If you need to mix it up from Terre Haute's easy-going vibes, then jump behind the wheel of your Budget rental car and see what else is out there.
CarRentals.com works with several of the finest businesses. With a name like Budget, you know they will try to get you the cheapest price. Founded during Los Angeles in 1959, Budget always strives to provide the best prices for customers.
Frequently asked questions
How do I get a Terre Haute Budget rental car at a great rate?
CarRentals.com always tries to get you the lowest rates, no matter when you book. However, reserving your car well ahead of your visit can help keep spending low. Be sure to go over the mileage policy and keeping it to one driver will reduce your expense.
What should I carry with me when I pick up my car in Terre Haute?
You will need to bring your driver's license and a credit card in your name.
What's Terre Haute's minimum age to rent a car?
Budget's minimum age to rent a car in Terre Haute is 21. Some rentals, especially higher category vehicles (luxury, SUVs, etc.), may have an added fee if you are under 25. Take time to review Budget's policies to know what the total cost is before you book.
Is there a particular car I should get for my trip to Terre Haute?
That depends on how many people you are traveling with and what you'll be doing when you visit Terre Haute. Compact or economy automobiles are good for short commutes and are easier to park. Commute times in Terre Haute average 31 minutes, so you may find a mid-size car or SUV provides a more comfortable ride. If you want to decrease your emissions and save on gas, then opt for a hybrid vehicle. Those looking for a little extravagance on their Terre Haute vacation can choose a higher-end model like an Audi A4 or Cadillac XTS or similar.
Do I need insurance when I rent a car in the United States?
You are required to have insurance before you rent a car from Budget in the United States. Although many of the major card issuers, like Visa or American Express, provide some coverage, there are usually restrictions. For instance, you may not be covered if you book a luxury or larger vehicle. Make sure to check credit card company's policy before you decide. Additionally, as a United States citizen, you can also book Collision Damage Coverage through CarRentals.com at checkout.
Do I need to pay a deposit when I book my Budget car rental?
Budget does require a deposit when you book your rental car. Budget will block the deposit on your credit once you reserve your vehicle for your trip to Terre Haute. Please note that the deposit can vary greatly based on the model and make of the car.
Do I have to return my Budget rental with a full tank?
We encourage a full tank policy. You pick up your Budget rental with a full tank. However, if you return the rental with less than the amount that you received it with, most companies will charge a premium, and sometimes up to 3X the amount of current fuel prices to refill it. If you want to save some money, it is best to fill up your tank before you bring your car back to Budget. Stations near or around airports or car rental places tend to have higher prices.
Why should I get unlimited miles?
Terre Haute's small-town atmosphere certainly has its charms, but you may want to take to the road again after you've checked off all the activities in Terre Haute.
Does Budget offer one-way rentals in Terre Haute?
Budget offers one-way rentals in most cases. You may find it easier to return your rental car at a different location. Don't forget there is typically an additional fee when you opt for one-way.
Book today for great rates
With so much to do and see in Terre Haute, having the keys to your own set of wheels lets you explore at your own pace. When you are ready to check out more of Indiana, you can drive when you want to, without having to coordinate a ride-share or hanging out a stop waiting for the bus.
Before you head out of town, book your Budget Terre Haute car rental and take off to all the must-do activities. Reserve with CarRentals.com and drive the highway in Terre Haute, Indiana.


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A completely armed F-16 fighter airplane has crashed at March Air Reserve Base exterior Riverside, California, damaging a close-by warehouse. The pilot ejected safely.
Firefighters in Riverside County, east of Los Angeles, have requested a hazardous materials response staff, as a result of the airplane was loaded with ordnance and exterior gasoline tanks, in accordance with KNBC-TV.
A bit of the airplane's cover and a parachute had been seen on the close by runway after the pilot ejected, surviving the crash. No accidents had been reported on the bottom.
Although footage from the scene clearly confirmed a big gap within the roof of a warehouse and particles resembling a jet inside, March ARB spokesman Major Perry Covington initially instructed KABC-TV that the airplane crashed at the top of the runway whereas touchdown, and didn't hit any buildings.