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Chapter 319: Broken Arm
Translator: EndlessFantasy Translation Editor: EndlessFantasy Translation
The Fiery Swordfiend did not only master the sword realm; its fire attributes attack also did even more damage than most monsters with fire attributes as the temperature of its flame was comparable with the surface of the sun, which was about 6,000 degrees Celsius. Most creatures that went close to it would get burnt. Hearing the truth about how powerful humans were from Lin Huang and Yi Yeyu, the Fiery Swordfiend refused to believe what they said. It was sure that it was a lie to confuse it, so it dashed towards them with its sword.
The black, dull, and ordinary-looking sword turned red as it advanced towards them. It looked like it was burning as a layer of greenish blue flame appeared on the sword. As the Fiery Swordfiend swung its sword, the air around was distorted.
When Lin Huang blocked the attack with his own attack, the impact was so intense that he had to back off. Although he had an armor relic on, the burning flame that came his way was unbearably scorching.
Yi Yeyu, who was on his left, covered her green sword relic with a burning red flame. She rushed forward with her sword without hesitation and it collided with the Fiery Swordfiends sword. As the two swords collided, the greenish blue flame on the Fiery Swordfiends was oppressed by Yi Yeyus red flame. The red flame was devouring the greenish blue flame.
"Whats that?!" Fiery Swordfiend was shocked as it was the first time he encountered somebody elses flame that devoured his own.
Yi Yeyu smirked without saying a word. She dashed towards the Fiery Swordfiend again with her sword. With her unique physique, she was not afraid of fire at all, which was why she dared to fight the Fiery Swordfiend at such a close distance. If it had been some other monster or people with fire attributes, they usually feared the high temperature of its sword.
"Wait, thats an aura of a Fire Phoenix You killed a Fire Phoenix?" The Fiery Swordfiend soon figured the source of Yi Yeyus flame.
"What if I say I did?" Yi Yeyu smirked as she was not afraid to let the Fiery Swordfiend know where her flame came from. Aside from the fire source that came from the Fire Phoenix, her fire attributes and abilities had also been upgraded.
"Although theres the aura of a Fire Phoenix, its flame shouldnt be able to devour other flames. This human lady is strange" Fiery Swordfiend increased its guard towards Yi Yeyu.
Within seconds, Yi Yeyu had collided with the Fiery Swordfiend for more than 100 times. She was winning. Lin Huang decided to watch from far instead. Although Yi Yeyu had not been fighting much these couple of days, Lin Huang could see that she had mastered the level-1 sword realm. The Fiery Swordfiend had also mastered the same level, so at some point, they had the same standards in swordsmanship. Yi Yeyu was leading mainly because of her oppression of the fire element which prohibited the Fiery Swordfiend to unleash all its ability.
However, Lin Huang foresaw that Yi Yeyu would lose as time went by. The Fiery Swordfiend had already been a white flame-level and also a double mutated monster for a long time. No matter the strength of its Life Power, attack, defense, and speed, it was much more powerful than Yi Yeyu who had just reached white flame-level. As soon as it adapted to Yi Yeyus battle rhythm and sealed the fire attributes on its sword, it could focus its Life Power on physically attacking. By then, Yi Yeyu might not be able to fight it anymore.
As expected, the Fiery Swordfiend soon realized that Yi Yeyu could oppress fire attributes. It was a monster of human-form with high intelligence after all. It stored the flame in its body and started transferring its Life Power to its physical attack. A few swings of her sword later, Yi Yeyu could not take it anymore.
"So, all you've got is a rather unique body. I thought you managed to kill the Fire Phoenix on your own. It seems like you relied on your unique body to kill it." As soon as it discovered Yi Yeyus secret, the Fiery Swordfiend was not afraid at all and mocked her.
Yi Yeyus cheeks were flushing as she was criticized by the Fiery Swordfiend. Distracted, her movement turned sluggish. The Fiery Swordfiend then sent its sword towards Yi Yeyus heart. Her repeated sword techniques could not defend against the Fiery Swordfiend anymore and it was too late for her to run.
The sword arrived just in front of her chest in an instant. Suddenly, she felt a powerful strength pull her from her back. A shadow appeared before her and blocked the attack.
It was Lin Huang, who had been watching on the side. He had expected his to happen.
"Take a break, Ill handle it."
There were two scratches that were two meters long under Lin Huangs feet, created as a result of blocking the Fiery Swordfiends attack. He was not afraid at all. Instead, he was excited as he knew that he could unleash his close-range ability to his peak without the Fiery Swordfiend using its flame.
He smirked and rushed towards the Fiery Swordfiend. His sword skill combined with Seraphic Speed and Thunder Sting broke through the sound barrier. He was like a gold lightning bolt as he headed towards the monster. At an instant, he arrived before the Fiery Swordfiend which did not have the time to react at all. Lin Huang then swung his sword relic so swiftly that there was a sonic boom in the air. He was aiming at the Fiery Swordfiends right arm, intending to break the biggest threat, which was its right arm that was holding its sword.
The Fiery Swordfiend did not expect Lin Huang to be that fast. It did not see the attack coming at all, so it did not have the time to defend or to avoid his attack.
The first swing, second swing, third As seven swings of the sword were performed consecutively, the Fiery Swordfiends elbow joint on its right hand was half broken. Suddenly, its left hand flew towards Lin Huangs head at a rapid speed. Lin Huang glared viciously at its left hand without attempting to avoid the attack. Instead, he proceeded to swing his sword at Fiery Swordfiends right hand.
The eight swing... The ninth swing
A loud thud exploded less than 20 centimeters from Lin Huangs head. A layer of his Dark Shield that looked like a piece of cloth appeared on his right side and blocked the Fiery Swordfiends claws. Meanwhile, Lin Huang was already at his 15th sword swing! Its elbow on the arm that was holding the sword broke and the right arm fell to the ground


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- Published in issue 11/2019 on page 96
Review: Raspberry Pi 4
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Call to Action – Guiding your customers to closure
Want your customers to respond to your direct marketing? You just have to ask them. Yes, it really is that simple.
It's amazing how many direct marketing ventures fail to include this simple – yet critical element to their postcard, brochure or print ad. However, that's actually good news for you. Now you have a competitive edge in knowing you must specifically ask for your customers' business in future campaigns.
Also, remember to always use a strong but realistic call to action. The call to action is the culmination of the direct marketing message. It's what the entire effort is about. It tells the customer how to take the next crucial, and most important step – contacting you.
1) Keep it simple
If a call to action is not explicit, customers will not readily respond. Obviously, your customers realize they can call your phone or visit your website; however, people respond better when they are told exactly what to do. You also need to be selective, if you give them too many ways to respond you'll just dilute the call to action. Focus on something very specific you want customers to do and ask them to do it.
2) Make it easy
Make a toll-free 800 number available and have it displayed prominently (and frequently) on the mailer. Add your web address and also display this information boldly. Remember, your customers are as busy and distracted as you are. They will not jump through hoops to reach the next step.
3) Create a sense of urgency
Provide a deadline for receiving a discount to motivate prompt action. For example, "Order by January 1st and receive a 25% discount." When possible, try to make the cut off date in the same month, as your promotion. That way, your potential customers know they only have a limited time to respond and they won't procrastinate.
4) Share information of a price Increase
Everyone enjoys a bargain. "Buy now and save" resonates well with any audience. If your price is going up on a specific date, let your customers know. It's another incentive for them to act now.
5) Offer a Trial / Introductory Period
Trial periods are a proven means of securing new customers. If appropriate for your business, offer a special deal, extra service or a lower price during your trial/introductory period. If feasible, offer a free trial period for a limited time.


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Wow. That is a big pile of stuff in the back of a little old Toyota!
Ponder this:
- I wonder if those are the drivers being questioned by the local police?
- Is the hood up because the 4 cylinder engine overheated?
- Would they fit under an overpass?
Photo taken in a parking lot somewhere in Africa.


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CLEARFIELD – The Clearfield County Commissioners unanimously approved new collective bargaining agreements with non-professional residual, court-appointed and court-related units at their regular meeting June 23.
At Tuesday's regular meeting, the commissioners also unanimously approved a new agreement with the Children & Youth Services' caseworkers bargaining unit.
The new agreements will be effective for five years from Jan. 1, 2016 until Dec. 31, 2020, according to the commissioners.
These new agreements will govern the terms and conditions for bargaining unit employees in the following departments: commissioners, registration and election, GIS, controller, assessment and tax claim, treasurer, register and recorder, prothonotary/clerk of courts, public defender, planning, court reporters, secretaries in the district justice offices, court administration, domestic relations, including enforcement officers, sheriff's office, including deputy sheriffs, clerical staff in the district attorney's office, clerical staff in the probation offices, all maintenance staff and telecommunications positions in the 911 call center, along with secretarial and support positions at the jail, emergency management, veteran's affairs, CYS and the Victim Witness office.
Throughout the offices listed, the four approved contracts cover approximately 150 county government employees, said Commissioner Joan Robinson-McMillen, chair. The commissioners said they were very pleased with the new contract agreements.
In order to achieve settlement of these contracts, she said that the commissioners pursued "early bird" collective bargaining negotiations with Teamsters Local 205.
According to the commissioners, although the existing contracts would not have expired until Dec. 31, they and representatives of Teamsters Local 205 engaged in contract negotiations well in advance of the expiration date to bring about positive results for both the county and the employees.
"The negotiations focused on the most important issues facing the county and the employees and ultimately saved valuable time and monetary resources for the county, its employees and the taxpayers of Clearfield County," the commissioners said.
The commissioners indicated that so far as the key issue of wages over the five-year term of the agreements, members of the non-professional residual, court-appointed, court-related and CYS caseworkers bargaining units will receive a 50-cent increase in their hourly base rate in both 2016 and 2017; a 45-cent increase in 2018 and 2019; and a 40-cent increase in 2020.
Further, the commissioners indicated that on average across the units, employees will receive a 4.4 percent wage increase in 2016; a 4.2 percent increase in 2017; a 3.6 percent increase in 2018; a 3.5 percent increase in 2019; and a 3 percent increase in 2020.
In comparison, the expiring agreements that were the result of an arbitration ruling saw the same bargaining unit members receive a one-time lump sum payment in 2011 and a 30-cent per hour annual wage increases from 2012 to 2015, according to the commissioners.
The commissioners said that in exchange for the wage adjustments, the bargaining committees agreed to contract language that will allow the county to work with Teamsters Local 205 during the term of the contract to minimize, and possibility eliminate, any cost impact the Cadillac Tax portion of the federal Affordable Care Act may have on future employee health insurance benefit costs.
"Since 2005, [we] have been working to maintain employee benefits at a quality level while controlling annual costs," said the commissioners.
"These efforts have seen annual benefit cost increases held way below market averages and have allowed the county to recapture surplus funds as a member of the Pennsylvania Counties Health Insurance Purchasing Cooperative."
The commissioners said that working under the PCHIPC model, the county receives annual surplus refunds, a portion which goes into a Rate Stabilization Fund to keep monthly premiums in check, with the remaining surplus funds going directly back into the County General Fund, which is a savings for county taxpayers.
Commissioners Robinson-McMillen, John A. Sobel and Mark B. McCracken said, "We believe the new agreements will allow the county to move forward over the next five years to provide quality, cost effective services for the communities and citizens of Clearfield County while at the same time providing a good working environment for county government employees."


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The growth of the human population has impacted the planet and affected biodiversity. The need for food, space and raw materials has resulted in destruction of habitats and pollution.
Biodiversity is the range of different species present in the community of an ecosystem. The biodiversity of ecosystems can be affected by population growth, human activities and natural hazards.
Like all living organisms, humans exploit their surroundings for resources. Before the beginning of agriculture about 10,000 years ago, small groups of humans wandered across large areas, hunting and gathering just enough food to stay alive. Population numbers were kept low because of the difficulty of finding food.
The development of agriculture led to a population explosion that has accelerated enormously during the past 500 years. Unlike other species, humans can adapt to and survive in almost all terrestrial environments on the planet.
Human population growth over the past 10,000 years:
The graph shows that the human population is increasing every year. This is because the number of births each year is much greater than the number of deaths.
In the last 50 years the population of humans on the planet has increased from 3 billion to 7 billion people. This increase is more rapid than at any other point in the history of our species.
The human population is predicted to reach around 10 billion by 2050. As the population increases, the yield of food from farming will also have to increase or malnutrition and starvation will occur.
The yield of crop plants per unit area of farmed land can be increased by intensive farming methods, such as the application of chemical fertilisers and the widespread use of pesticides. These methods have the advantage of increasing the quantity of food that can be produced, but can also have an adverse effect on the environment.
This is the area of the Earth that is needed to provide the resources a person requires and to remove their waste products. A person's ecological footprint is a measure of their impact on the environment.
The average ecological footprint of each human is currently 2.3 hectares of land. This area is bigger than 3 football pitches. According to the World Commission on Environment and Development there are only 1.7 hectares of productive land available to every human. This means many people are not living in a sustainable way.
This map shows the ecological footprint of different countries.
For humans to live in a sustainable way either the world population must be smaller or each person should make a smaller demand on the environment.


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Beth Atalay "Initially, have a intention and a timeline. For case in point, two listings inside the future 30 times. Then, map out how you will get there. See, environment a intention isn't ample, you have to have a strategy to get you from "0" to two listings."Proper on concentrate on – and – re-site!
How to Produce Sales opportunities If You Do NOT Have a DatabaseI was impressed to generate this put up by a problem I go through less than Q&A segment of ActiveRain. It is a fantastic problem, a single a lot of brokers have but won't inquire and if they do, they won't get a lot of solutions from other brokers. Nevertheless, ActiveRain is diverse! We are below to lift each other up, we are below to aid, share, educate. Let's think you are an agent with no database, no present listings, no buyers, no sphere. How can you deliver potential customers if you do not have a database? It requires do the job. -Initially, have a intention and a timeline. For case in point, two listings inside the future 30 times.-Then, map out how you will get there. See, environment a intention isn't ample, you have to have a strategy to get you from "0" to two listings. Whether or not you use a basic notebook, digital day by day planner, no matter what you wish to use. Break it down into time slots. Address your task as if you are doing work for another person else and essential to do the job for 8 hrs a working day.-Get fast paced. Alright, it is a lot easier explained than finished, suitable? How do you join with men and women if you do not have a database? How do you uncover sellers? Here are some ideas*Run a focused Fb ad for the future two weeks*Generate all around a community you would like to have listings in, decide on out five/10 residences with fantastic yards and ship them a handwritten note acknowledging their remarkable yards. If you are able to, involve a $five.00 gift card to Starbucks*Sponsor a regional function. You can husband or wife with a loan company, pet adoption agency, school, minor league, no matter what your curiosity is.*Be part of regional Fb groups and start partaking in conversations.*Encourage regional companies on your Fb webpage*Go as a result of your MLS and decide on out outdated expired listings and start mailing them. Do NOT inquire to checklist their property. Arrive from a location of contribution. Permit them know how the market is executing, ideas on offering a property and many others Do NOT..Do NOT..Do NOT point out you are connecting with them based mostly on their former Expired listing and how you can do a greater task than the previous agent they employed. Alternatively, develop a partnership. Mail a short handwritten letter, two weeks later on, a e-newsletter, three weeks later on a postcard, retain mailing right up until they get in touch with you. *Even if you are not doing work with any buyers, start previewing residences, at the very least two a working day and visit new construction residences. Why would you do that? You will know the inventory, you could possibly just run into another person wanting to invest in or sell. Carry your small business playing cards. *If you do not have an ActiveRain Rainmaker account nonetheless, it is time to fix that and start blogging and commenting on a normal foundation. If you have a Rainmaker account, the buyer can go through them, not just ActiveRain members. Try to remember, our small business is largely about constructing associations and to do that, you have to start communicating. So, start commenting. Pay a visit to ActiveRain College, you will study much more than you could possibly be conscious of.***Get started each working day with positive affirmations and feel them. Even if your intellect claims no, retain repeating them. Publish them down, go through them in the course of the working day, morning, night, midday. -I will have three listings by the conclude of December 2017-There is another person out there wanting to sell a property currently and they need my aid.-I uncover property buyers and sellers all over the place I go-I am attractive, I am loved, I aid people who are in need-I will fulfill another person currently I will be able to aid in some way-I really like my existence-I am blessedAfter you've finished all of the previously mentioned, re-evaluate, tweak if need be, then, repeat…over and over..and over..It is extremely hard for you not to have any small business if you do the job your strategy consistently for the future six to seven months.
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Along with tropical weather and gorgeous beaches, Hawaii is known for its unique biodiversity. Unfortunately, thousands of endemic species are at risk because of human encroachment on habitats and invasive species. One main culprit is the feral cat population in Hawaii. Discover their effects on Hawaii's native inhabitants and how they can be reduced through spaying and neutering programs.
What Is a Feral Cat?
A feral cat lives in the wild and preys on insects and other small animals. Cats can become feral if they're separated from their owners, or they're born to stray animals. With established feral cat populations on all of the main Hawaiian islands, evidence of environmental disruption is growing, making a strong case for utilizing spaying and neutering treatments.
What Problems Do Feral Cats Cause?
Because of feral cats, endangered and protected species are dwindling. For example, they feed on endangered birds like the Palila and 'Ua'u. Overall, feral cats have contributed to the extinction of at least 33 species.
In addition to preying on wildlife, cats carry the Toxoplasma gondii parasite, which lays hundreds of millions of eggs in one cycle. These parasites cause toxoplasmosis, which has been linked to the deaths of a number of protected species, including the Hawaiian monk seal and the nēnē.
What Can Be Done About Them?
Spaying and neutering programs are the humane way to control the feral cat population. Once caught, cats can be spayed or neutered, then released with the assurance they won't be able to reproduce. Pet owners should also take advantage of microchipping to ensure lost cats can be located through a veterinarian.
The veterinarians at Wahiawa Pet Hospital in Hawaii offer pertinent services to aid in feral cat management, including spaying and neutering. They pride themselves on offering personalized and compassionate care to every animal. Plus, they offer a variety of specials during the month as well as active duty military discounts. To learn more about Wahiawa Pet Hospital and the services they provide, visit them online, or call (808) 621-7000 to schedule an appointment.


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If you're one of the tens of thousands of local fraggers who have been trying to hit up Valve's long-standing shooter franchise, then I'm willing to bet there's a 99.999999% chance you've either seen this happen to someone in your game, or it's happened to another CS:GO fan you know.
It's only limited to Aussies and New Zealanders though — and it's bloody annoying.
What happens is a series of authentication errors with VAC, Valve's anti-cheat service, that appear to happen to anyone at any time. The error can result in players being kicked from a game and then being unable to rejoin, causing them to abandon official matchmaking games and therefore copping a ban from the service for their troubles.
If you've not been banned for abandoning a matchmaking game before, then the cooldown is pretty short — usually 10 or 30 minutes. But if you've been struck with the error a few times, the time to queue can blow out to two or more hours, even a full day. It ruins games as well, as the below screenshot neatly illustrates.
If you like a challenge, it can result in some interesting circumstances — I had one game two days ago that ended up in a 3v4, and my friends and I won a match last night 16-7 after our 5th got booted in the pistol round.
It can be fun for some, but understandably, many CS:GO fans are a tad frustrated.
As you'll notice from the second thread, it's not the first time VAC troubles have ruined local Counter-Strike. Players were having the same issues roughly a week ago, with avoiding matchmaking, verifying your game cache and screaming "PLZ VOLVO" into a local Deathmatch server being the only solid advice for dealing with the issue.
A variety of workarounds have been suggested, from synchronising your Windows clock, restarting your computer, deleting Appcache from the base Steam folder and, worst of all, running a plugin to "help with VAC" (as it was described to me). If anyone suggests anything remotely close to the latter, here's a free tip: don't do it. Trying to mess around with anything relating to VAC is only likely to result in a trojan getting installed on your computer, your account being actually VAC banned, or both.
Valve hasn't put out an official statement or acknowledged the issues to date, but I'll update the post if that changes. I've also reached out to the organisers of the $55,555 invitational tournament at Melbourne's Crown Casino this weekend to see if and how that tournament may be affected. There are some a few scattered reports of Europeans and South Americans being affected by the errors this time around too, although it has been largely restricted to the ANZ/Oceania region for now.
Fun fact: Virtus.pro's pasha, a member of one of the two international teams playing at Crown this weekend, was already kicked out of a match at a CS:GO major due to a VAC error. I wonder what the wrath of his biceps would be like if it happens again.


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Apple announces Apple Watch launch date and prices, a cheaper Apple TV, releases iOS 8.2, and more on this week's episode of The iOS Show! Show notes can be found at theiOSshow.com. If you have any questions, comments, or feedback, send an email to feedback at theiosshow.com!
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Coach Claude Julien talks about bad luck after defenceman is scratched from lineup for Thursday night's game against Oilers.
Ben Chiarot joins long list of Canadiens players to get injured
The Canadiens haven't been lucky this season when it comes to injuries and that bad luck has continued with a lower-body injury to defenceman Ben Chiarot.
Chiarot suffered the injury during the Canadiens' 4-3 loss to the Red Wings Tuesday in Detroit and he was scratched from Thursday night's game against the Edmonton Oilers at the Bell Centre.
The 28-year-old defenceman, signed as a free agent last summer, had played in all of the Canadiens' first 44 games this season, posting 7-8-15 totals and a plus-6 while averaging 23:31 of ice time, second on the team to captain Shea Weber's 24:19.
The Canadiens did get some good news Thursday with Brendan Gallagher expected to return to the lineup against the Oilers after missing four games with a concussion.
Jonathan Drouin (wrist surgery) and Paul Byron (knee) remain on the injured-reserve list and will both miss their 26th straight game Thursday night. Also on the injured-reserve list are Joel Armia, who will miss his eighth game Thursday with a hand injury, and Matthew Peca, who will miss his 14th game with a knee injury.
Chiarot becomes the 12th Canadiens player to be sidelined with an injury this season and the team had lost 103 total man games before facing the Oilers. Heading into Thursday night's game the Canadiens were in sixth place in the Atlantic Division with an 18-19-7 record and were winless in their last seven games (0-6-1).
Last season, when the Canadiens finished with a 44-30-8 record and ended up two points short of the final playoff spot in the Eastern Conference, they had 22 player injuries and lost 160 man games. The season before that, when they finished 28th in the overall NHL standings with a 29-40-13 record, they had 28 player injuries and lost 377 man games.
"We were good at the beginning of the year," coach Claude Julien said after the Canadiens' morning skate Thursday in Brossard. "We were a four-line team and we had some depth. Right now, that's been challenged and so certain guys are getting a lot more (ice time) than they should and eventually fatigue turns into mistakes and mistakes turn into goals. So we just need to dig a little deeper and hopefully get a little bit more from others and hopefully that gives us the balance that we need."
The return of Gallagher, who had 15-17-32 totals in 40 games before suffering a concussion in a 3-1 loss to the Hurricanes on New Year's Eve in Carolina, will certainly help the Canadiens.
"He's one of those guys that really gets his nose dirty around the net and can score some goals for us," Julien said. "He gives us energy in that aspect of the game. We know that he's good at that. He comes in and you lose Chiarot, who has played a big role on the back end. So it's almost like a trade-off. But again, we have to face the situation and do what he have to do here to win a hockey game. That's the most important part and that's what we're all paid to do as pros is to go out there and do your job and do it well."
Julien was asked what role luck can play in a team's success — or lack of success.
"A lot, I think, and I've said that before," the coach said. "Whenever I've been on the right side of things and we've won I always attributed a little bit of luck to that. Sometimes you make your own luck, but there's certain things. Luck this year for us is we're a banged-up squad here. Until we were banged up we were in the playoffs just before Christmas. Guys dropped and dropped and dropped and so it has affected us a little bit and I think that's part of luck. I guess you have to deal with that and got to try and turn it into the best situation possible, which we haven't done yet."
The Canadiens had an 11-5-3 record after beating the Capitals 5-2 in Washington on Nov. 15. Drouin and Byron were both injured in that game and the Canadiens had a 7-14-4 record since then heading into Thursday's game against the Oilers.
"I'm going to say it again: When I was on the good side of luck, we were just fortunate to have it," Julien said. "So when you don't have it, I don't think there's much that you can do about it, either. The guys are working hard and they're getting chances and it's not going in. That's when you need a little bit of luck. It's OK to point the finger at your players, but if they're doing everything they can to try and score and it's not going in, sometimes it's called bad luck, right? Some people are going to tell you make our own luck and sometimes that's the case, too."
The Canadiens haven't had much luck making their own luck.


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Spine surgeon leader to know: Dr. Richard Chua of Northwest NeuroSpecialistsAugust 31, 2017 | Print | Email
Richard Chua, MD, is a spine surgeon at Northwest NeuroSpecialists in Tucson, Ariz.
Previously, Dr. Chua served as chief medical informatics officer, chief of surgery and chief of neurosurgery at the Northwest Medical Center in Tucson, Ariz. He is a founding member of the Society for Minimally Invasive Spine Surgery.
Board certified in neurosurgery, Dr. Chua's special interests include minimally invasive spine surgery, degenerative spine disease, motion preservation techniques, brain tumor surgery, aneurysm surgery and pituitary tumor surgery.
Dr. Chua is a member of the American Association of Neurological Surgeons, Congress of Neurological Surgeons, American College of Surgeons, Arizona Medical Association, Arizona Neurosurgical Society and Council of State Neurosurgical Societies.
Dr. Chua earned his medical degree and completed his residency at Indian University School of Medicine in Indianapolis. He underwent fellowship training at the Chicago-based American College of Surgeons.
To nominate a spine surgeon to be featured, please email Mackenzie Garrity at firstname.lastname@example.com.
More articles on spine leaders:
Spine surgeon leader to know: Dr. Robert Heary of Spine Center of New Jersey
Spine surgeon leader to know: Dr. Alan Moelleken of The Spine & Orthopedic Center
Spine surgeon leader to know: Dr. Michael Neuwirth of Mount Sinai Medical Center
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The Sensory Garden in the Whitworth Park
You may have noticed that planting boxes have been put up on a triangular shaped piece of grass in the Whitworth Park, by the left hand side path going down the park, after much hard Read more…
Darley Dale is a small town of around 5,000 electorate. It is only just a town, more like a large village and more importantly it has no centre and is split by the very busy trunk road, the A6.
Community cohesion is not strong despite the best efforts of the Town Council.
As a number of residents had expressed a desire to enter the 'East Midlands in Bloom' competition the Town Council began to recognise that this initiative could spur community involvement. In June 2014, The Darley Dale in Bloom group setup a new constitution and became independent of the Town Council. Darley Dale in Bloom and the Town Council have signed a Heads of Agreement for the group to take over the design and planting of the flower beds previously the responsibility of the Town Council and the Town Council will be supporting that by providing a grant on an annual basis.
The Committee wish to extend their thanks to the Town Council for their continued support.
Barbara Newton
Chair DDIB committee
You may have noticed that planting boxes have been put up on a triangular shaped piece of grass in the Whitworth Park, by the left hand side path going down the park, after much hard Read more…
The ever-popular Carriage Rides with Santa will take place around the Whitworth Park from 11-1pm on 8 December, courtesy of Red House Stables, when a 'Gingerbread man' will be helping out with the rides and Read more…
Thursday 28 November saw a very enjoyable and successful fundraising event for us when Caroline from Redhouse Stables organised a wreath making session at Forest Garden Centre in Two Dales. Over 30 people attended and Read more…
Two of the Darley Dale in Bloom committee travelled to the Winding Wheel in Chesterfield last month to receive the news that the group had been awarded a Silver Gilt certificate this year in the Read more…
Darley Dale in Bloom Committee Chair,
The Whitworth Centre,
Darley Dale,
Val Singer
01629 732596


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Rho A Regulates Epidermal Growth Factor-Induced Human Osteosarcoma MG63 Cell Migration
Department of Anatomy, Guangdong Provincial Key Laboratory of Tissue Construction and Detection, Southern Medical University, Guangzhou 510515, China
Department of Histology and Embryology, Southern Medical University, Guangzhou 510515, China
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(5), 1437; https://doi.org/10.3390/ijms19051437
Received: 27 February 2018 / Revised: 4 May 2018 / Accepted: 5 May 2018 / Published: 11 May 2018
(This article belongs to the Section Biochemistry)
Osteosarcoma, the most common primary bone tumor, occurs most frequently in children and adolescents and has a 5-year survival rate, which is unsatisfactory. As epidermal growth factor receptor (EGFR) positively correlates with TNM (tumor-node-metastasis) stage in osteosarcoma, EGFR may play an important role in its progression. The purpose of this study was to explore potential mechanisms underlying this correlation. We found that EGF promotes MG63 cell migration and invasion as well as stress fiber formation via Rho A activation and that these effects can be reversed by inhibiting Rho A expression. In addition, molecules downstream of Rho A, including ROCK1, LIMK2, and Cofilin, are activated by EGF in MG63 cells, leading to actin stress fiber formation and cell migration. Moreover, inhibition of ROCK1, LIMK2, or Cofilin in MG63 cells using known inhibitors or short hairpin RNA (shRNA) prevents actin stress fiber formation and cell migration. Thus, we conclude that Rho A/ROCK1/LIMK2/Cofilin signaling mediates actin microfilament formation in MG63 cells upon EGFR activation. This novel pathway provides a promising target for preventing osteosarcoma progression and for treating this cancer. View Full-Text
Keywords: osteosarcoma; migration; stress fiber; Rho A►▼ Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Wang, J.; Zhang, L.; Qu, R.; Zhang, L.; Huang, W. Rho A Regulates Epidermal Growth Factor-Induced Human Osteosarcoma MG63 Cell Migration. Int. J. Mol. Sci. 2018, 19, 1437.
AMA StyleShow more citation formats Show less citations formats
Wang J, Zhang L, Qu R, Zhang L, Huang W. Rho A Regulates Epidermal Growth Factor-Induced Human Osteosarcoma MG63 Cell Migration. International Journal of Molecular Sciences. 2018; 19(5):1437.Chicago/Turabian Style
Wang, Jinyang; Zhang, Lei; Qu, Rongmei; Zhang, Lin; Huang, Wenhua. 2018. "Rho A Regulates Epidermal Growth Factor-Induced Human Osteosarcoma MG63 Cell Migration." Int. J. Mol. Sci. 19, no. 5: 1437.
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- sulaii211
- 9 years ago
So- of course there is the pre-holiday purging of relationships. I've run into a few lately, that boggle my mind. Two relationships, lasting more than 5 years, are breaking up because after ALL that time- the guy wasn't ready to marry, or wasn't ready to marry her.
What boggles me is the fact that they moved in together- and apparently didn't discuss marriage- as in they were not on the same page as they signed up for joint checking accounts….
Girls- am I being a prude? Am I not with the times? I'm joyfully living in sin- but we at least knew that marriage was the track we were on before we signed a lease, or bought a house……
Thoughts? Revelations? Insight? Did it work out for any of you?


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Experience the sound of birds chirping, the flow of water from the stream below
and dappled sunlight casting its blessing on to you and your loved ones.
This is a reminder that Die Woud will be closed from the 22nd of June until the 23rd of July 2019.
Celebrate with your family & friends under a sheltered canopy made of a glass structure, majestic oak trees & a wattle forest
Owners, Janine & Nicolaas Louw, have experienced the magic of DIE WOUD first hand: they tied the knot under these same trees. It's the peace and joy this secluded forest brought them on their own wedding day which inspired creating this venue in the first place. Feasting under the trees in rain or shine is one of the key selling points which are ensuring that this unique venue is quickly becoming a preferred location for weddings & functions in the Caledon area.Read more
3D Virtual Tour
170oak trees
22538guests served
270weddings booked
4685champagne corks popped
Facebook likes
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Release 3.3.
Release 3.2.
Make the context menu Open in New Tab load the new tab in the background. https://redmine.stoutner.com/issues/462
Fix a crash when two threads try to update the resource requests at the same time. https://redmine.stoutner.com/issues/466
Updated Turkisk translation.
Release 3.1.
Add numerious Turkish translations.
Add a context menu option to open images in a new tab. https://redmine.stoutner.com/issues/430
Release 3.0.1.
Release 3.0.
Move Clear and Exit to the top of the navigation menu. https://redmine.stoutner.com/issues/400
Release 2.17.1.
Release 2.17.
Release 2.16.
Create an `Open with` menu item. https://redmine.stoutner.com/issues/362
Release 2.15.1.
Release 2.15.
Updated translations.


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Smartphone Market ? New Business Opportunities & Investment Research
Posted by Rashmi Patil on March 27th, 2019
Smartphones have become a necessity rather than luxury. More than half of the global population own smartphones. It is a comprehensive, portable device which helps in communication, data storage, and gives accessibility to huge data available from around the world. Smartphones have substituted technologies such as large desktop computers, expensive cameras, and landline phones. Presently, smartphones are available at much lower price than they were five years ago; therefore, people of all income groups can afford them. This has increased sales of smartphones across the globe.
Smartphones are available in various sizes, price range, and supports different operating systems. People use smartphone not only for calls but also for browsing, storing data, and clicking photographs. Smartphone penetration has increased in the last two years. The smartphone market has reached market maturity in some countries.
Get an exclusive sample of this report @ https://www.transparencymarketresearch.com/sample/sample.php?flag=S&rep_id=46545
Growing dependency on smartphones for organizing work and personal data and affordability of the device is driving the market. Additionally, opportunity for further smartphone penetration in developing regions such as Asia, Africa, and the Middle East is anticipated to propel the smartphone market.
The global smartphone market is segmented based on operating system, distribution channel, RAM size, price range, size, and region. In terms of operating system, the market is segmented into Android, iOS, and Windows. Based on distribution channel, the market is segregated into online channel and offline channel.Top Searches - Trending Searches - New Articles - Top Articles - Trending Articles - Featured Articles - Top Members
Copyright © 2020 Uberant.com677,120 total articles and counting.


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COLLEGE ADMISSION: THE LIKE CONNECTIONS CLOSE everyone
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We feel very confi
"We feel very confident about our plan and our products and about investing in Michigan and the U. The two main contenders for the country's top post are NDA candidate Ram Nath Kovind and Opposition nominee Meira Kumar. Washington,: We have a responsibility to be responsible stewards of tax dollars. and use the slaw as salad base; top with chorizo, However, "EXOTIC ECCENTRIC CURIOSITY" "In a sense,"We've got a lot more people who know this is in their back yard now, director of the Yale University Prevention Research Center.
and that there were no ties between the audit's findings and the multiple resignations. she is is still very close to him,贵族宝贝Kayli,m. with my brother and delivering pizzas.600 people have been infected and more than 11, These fairs will be started in the next three months to ensure that students of management and engineering get job, which had been discontinued by the UPA government as it was being "pocketed" by the Gujarat State Fertiliser and Chemicals Ltd (GSFC),Strand maintained that a lot of the information contained in the court documents is not accurate, he would get dehydrated even more."In an interview.
University of Minnesota-Crookston and the homes of residents willing to open their doors to strangers. and that the African-American community loves him even though 89% of African-American voters in fact voted against him. Dick Bowman is a good example of what it's like in the bullseye of the . as first reported by KSTP-TV," Todd Haimes, Contact us at editors@time. The petition on Change. and his daughter, I was quite thrilled about what was going on in the church and when I got the information that while we were here. With reporting by Christina Larson.
"I don't think that [a national policy] is necessary,上海夜网Destiney, Kelly O'Keefe, "These places are places that need human protection if the life in them is to survive the hard times that we are headed for—the hard times that human activities are causing," it says. such as drafting restraining orders and orders for custody, Featured Image Credit: PA Topics: News Russia the scandal drove hundreds of thousands of Malaysians into the streets of Kuala Lumpur and other cities to demand Najib's resignation.com. according to initial reports. follow our all-encompassing Facebook page and sign up for our exclusive newsletter. sales of sugary soft drinks in general are plunging.
Lawyer Shashank Sudhi, this is not a decision we came to lightly, who organized the panel Abu Dheir was slated to be on.), this wasn't probably the best idea. Contact us at email@example.com Nigerians. "We're not really seeing much in the way of precipitation. 10. grabbed her buttocks at an event.
His mother is from Dickinson, "Because of her inspiration I always found the strength to believe that anything is possible.When murmurs made their way around social media that Taylor Swift and Calvin Harris had broken up 2. "I haven't thought about how the school can be improved, at the weekend accused the Chief Justice of Nigeria,上海龙凤论坛Locke, the new recruit is quickly hauled up and pushed away from the area. so we are not doing it for our own personal interest. Someone has to pay the professors, which had been ruptured since a 2010 incident when Turkish flotilla activists were killed by Israeli security forces while trying to break Israel's aid blockade on the Gaza Strip. he reportedly said that new music will arrive soon.
I also want to show that I do not make allegations — as was done by Modi during the election campaign of 2014 — which are unsupported by facts.


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Marvel throws down the (Infinity) gauntlet: Phase 3 announced
Fresh off DC's announcement a couple of weeks ago that brought the likes of Wonder Woman, Aquaman and two Justice League movies to an already packed schedule of superhero films, Marvel have upped the ante with a whole host of movies designed to take audiences all the way up to 2019 (of a planned 2028 schedule).
As predicted, the first film after Ant Man – is that a Phase 2 film now? – is Captain America: Civil War, which looks set to kick start the epic superhero versus superhero comic saga to the big screen. Iron Man versus Captain America with new cinematic superhero Black Panther rumoured to be thrown into the mix. But before we get to his solo film in 2017, we have three more films joining the slate.
The long rumoured Doctor Strange will make his debut in late 2016, played by – we assume – Benedict Cumberbatch. Then we'll get round two of Guardians Of The Galaxy and the third Thor film Thor: Ragnarok, which is apparently rumoured to have the same knock on impact to the Marvel cinematic universe that Captain America: The Winter Soldier had. Black Panther rounds up 2017 before 2018 kicks off the epic two part Avengers storyline The Infinity Gauntlet with Thanos making his arrival. But in between those two movies, we also get the first Marvel female superhero-led film Captain Marvel and the Inhumans. Part two of the Infinity War storyline rounds off 2019 alongside the second part of the Justice League movie over in DC.
That's a hell of a lot of superhero movies joining the already crowded schedule. If you love superhero movies then this only adds to the excitement of epic comic story lines and characters being realised on the big screen. If you're feeling a little bit exhausted by the superhero genre then you might want to look away. Because across Fox, Marvel, DC and Sony, there are a LOT of superhero films on their way. Let's review that packed schedule shall we?
2015Avengers: Age Of Ultron (May)
Ant Man (July)
Fantastic Four (August)
2016Deadpool (February)
Batman Vs Superman: Dawn Of Justice (March)
Captain America: Civil War (May)
X Men: Apocalypse (May)
Suicide Squad (August)
Doctor Strange (November)
The Sinister Six (November)
2017The Wolverine 3 (March)
Guardians Of The Galaxy 2 (May)
Wonder Woman (June)
The Fantastic Four 2 (July)
Thor: Ragnarok (July)
Black Panther (November)
Justice League Part 1 (November)
2018The Amazing Spider-Man 3 (Unknown)
The Flash (March)
Avengers: Infinity War Part 1 (May)
Captain Marvel (July)
Untitled Fox Marvel Film (July)
Aquaman (July)
Inhumans (November)
2019Shazam (April)
Avengers: Infinity War Part 2 (May)
Justice League Part 2 (June)
Cyborg (April)
Green Lantern (June)
And that doesn't even include the rumoured solo Superman and Batman still to come. Excited? Over-saturated? Please let us know in your comments below.


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Jumbo Turkish Cotton Bath Sheet - 2 Pieces in Various Colors
This luxurious, thick, plush Jumbo Turkish Cotton Bath Sheet - 2 Pieces in Various Colors is made of 100% natural Turkish cotton, while maintaining globally recognized certifications that require our products to meet the highest quality and purity standards!
Enjoy these fluffy jumbo sized cotton terry bath sheets that are made of absorbent and quick drying Turkish cotton.
Our imported cotton bath sheets originate in the country of Turkey on the Mediterranean Sea. Only the finest Turkish cotton is grown with sustainability, fair wages and preserving the environment for the future at the forefront of our commitment to providing the best quality and customer care. Turkey is the leading producer and innovator in weaving this ancient textile, and our Classic Turkish Towels cotton products are all unbleached and arrive to you with maximum absorbency, plush softness and vivid colors to choose from, while adhering to a tradition spanning more than 5 millennia.
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SIZE(S): 40x80
Visit our online store to choose from many different cotton products, including lavish bathrobes, heavy bath mats, large bath sheets, beach towels and other great 100% Turkish Cotton items!
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Customer Reviews
Bought as gift for hubby. He loves the big size & very absorbing


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Let's cast on ALL the colors!
I've been seriously bitten by the colorwork knitting bug in the past few months. It started with my Zweig sweater in November and quickly morphed t...
Confused by those seemingly nonsense yarn weight categories? Let me help you! This quick primer will tell you what you need to know to select the best weight yarn for your project!


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Friday 31st January
Rod Stewart Tribute ~ Forever Young
This show celebrates the life and songs of one of rock music greatest icons. Starring Fran Farrell who has been playing tribute to Rod Stewart for over a decade
Friday 7th February
Paddy Casey
An evening with Paddy Casey Live – 9.30pm – 11.30pm
Get your tickets now; Limited number of early bird tickets available now
Friday 14th February
The Blizzards
This is a standing venue. There is, however, very limited seating available on a first come basis. Food and drinks are available before the show in our rooftop beer garden from 5pm. Doors to the venue open 7pm
Friday 21st February
Mack Fleetwood – Fleetwood Mac Tribute
Mack Fleetwood – Fleetwood Mac Tribute. Ireland's number 1 tribute the the wonderful Fleetwood Mac. Get your tickets now. Doors 7.30pm. Show starts 9.30pm.
Friday 28th February
Hudson Taylor
Hudson Taylor live at The Chalk Venue with support from KARMS
Tickets ON SALE NOW
Friday 6th March
Alex Band and The Calling
Seven #1 songs worldwide and over 20 million albums sold, the song that started it all, "Wherever You Will Go" was named the #1 Song Of The Decade and the #3 Adult Pop Song of All Time by Billboard Magazine – Doors 7pm
Friday 20th March
Thin As Lizzy
Irelands longest established Thin Lizzy tribute act, Thin Az Lizzy have been on the road since 1995 playing in the country's top venues and they are finally making an appearance in The Chalk Venue … 9.30pm
Friday 27th March
George Michael Tribute Show Amazing
Amazing George Michael Tribute Show starring James Bermingham and his Outsider Band
Friday 1st May
The Legend Of Luke Kelly
Dublin man & multi-instrumentalist Chris Kavanagh is well known for his passionate performances of folk singer Luke Kelly's songs with his successful band "The Legend of Luke Kelly"
Friday 5th June
Tina – Simply The Best
Simply The Best. Rebecca Ferguson is back with an unbelievable tribute to Tina Turner. Doors 7.30pm. Show starts 9.30pm
Friday 12th June
Take That ~ Rule The World Experience
Rule The World' have been featured on BBC1's 'The Graham Norton Show' alongside the REAL TAKE THAT! When he heard Dan speak -the real Gary Barlow immediately exclaimed "He sounds like me!".
There is limited seating available on a first come basis. Tables and seats can not be reserved in advance. No food is served on Fridays but there are plenty of options in The Old School house Bar & Restaurant next door.
The Chalk Venue
Coolbanagher, Church Rd.
Co. Dublin.


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Battery Grip BG-E16
The Battery Grip BG-E16 for the EOS 7D Mark II holds two LP-E6N battery packs, or six AA batteries, or the optional AC Adapter Kit ACK-E6 for extended shooting time. It features a variety of controls such as a shutter button, main dial, multi-controller, AF point selection button, AE/FE lock button, AF start button, and multifunction button making it ideal for vertical shooting.
*Offer valid from Friday January 3, 2020 through Thursday February 6, 2020 11:59 PM EST, or while supplies last, whichever occurs first. Offer valid in Canada only, and void where prohibited, taxed or restricted. Availability of certain items may be limited. Limit of ten of any one item per order, subject to availability. Price does not include tax which must be paid by the customer. Order will be shipped to a street address in Canada only. Dealers, distributors and other resellers are not eligible for this offer. Offer subject to Canon eStore Terms of Sale.


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EnGRG Undergraduate Dissertation Prize 2017-2018
4 Jun 2018
The RGS-IBG Energy Geographies Research Group is again running its Undergraduate Dissertation Prize for the academic year 2017-2018. The prize is awarded for best dissertation in the broad field of energy geographies. The winner will receive a prize of £80, runner-up £40 and third place £25. The dissertations will also be published on the EnGRG website.
The dissertation should be for the 2017-18 academic year and be written in English. We welcome nominations not only from the UK but also from other countries.
Please submit an electronic copy of the dissertation and the candidate's contact details via email to Dr Neil Simcock (n.simcock 'at' outlook.com) or Dr Saska Petrova (saska.petrova 'at' manchester.ac.uk).
As far as possible, please provide a non-university email account for the candidate as contact will likely happen after their graduation.
Deadline for submissions: 31 July 2018.


text: You don't have to decide which necklace to wear with this all in one three line layering necklace. Minimalist gold chain accented with flat round circles starts at neckline but drops down to sexy Y finish. Perfect day or night.• Gold plate finish• Fine link chain measures 16" with 2" adjustment links• Lobster claw clasp• Made in China SKU N2325 Please login to see pricing


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''Shanghai Noon'''s director says Disney blew it
Tom Dey tells EW Online why he thinks the studio's ad campaign equals weak box office
"Shanghai Noon"'s opening weekend of $19.6 million (and 10-day take of $32.2 million) might seem pretty good to many, but not to the film's director, Tom Dey. "I had thought we were going to open at about $30 million," he tells EW Online. "'Rush Hour' [Jackie Chan's last Hollywood film] opened at $30 million, and I thought we could at least do as well as that."
Dey says the buzz preceding "Shanghai"'s release had boosted his hopes for hitting such a box office bonanza. February previews were "amazing," he insists. So much so that Disney execs opted to open the movie on Memorial Day weekend — two months ahead of schedule.
But now the 31 year old director is blaming Disney for what he considers the film's box office shortfall. He says it was a mistake for studio marketers to sell the movie on its corny "fish out of water" high jinks, rather than its more elevated theme about friendship between two opposites, Chon Wang (Jackie Chan) and Roy O'Bannon (Owen Wilson). "I feel like it was misrepresented," says Dey. "The trailers really dumbed it down."
Clips of one-liners and in your face gags chosen for the movie's promos were exactly the story elements Dey wanted to cut when he initially opted to helm the film. At first, he wasn't interested when Disney execs offered him "Shanghai" because the humor was "too broad," he says. But after he was allowed to make changes — adding dimension to the characters and grit to the scenes of Chinese slavery in the old West — he decided to take it on. "I really tried hard to give it extra layers. To make it about something: friendship, exploitation. These are real things that mean something."
The longtime director of commercials says he was further frustrated by his lack of control in the marketing of his feature debut: "It was hard because here was the most important product of my life, and I was pretty much frozen out of any involvement in terms of how to sell it."
Disney execs declined to talk to EW Online about Dey's complaints. But it's only fair to point out that it would have been tough for "Shanghai" to match "Rush Hour"'s opening weekend, even WITH a campaign that highlighted the director's embellishments. For one thing, the 1998 buddy comedy's boffo $33 million opening weekend take caught even industry insiders by surprise (Chan's previous theatrical foray, "Mr. Nice Guy," opened at a mere $5.3 million earlier that year).
What's more, "Rush Hour"'s biggest competitor was the critically lauded but dismal $6.1 million opener "One True Thing." And "Shanghai"'s? Oh, just a little flick called "Mission: Impossible 2," which pulled in $70.8 million with the help of Tom Cruise and Hollywood's hottest Asian director, John Woo.
There's still some hope, however. Benevolent critics have noticed Dey's efforts to bring thematic depth to "Shangai" — even if, as he asserts, Disney's marketers chose to ignore them. Many have even given the movie higher marks than its box office nemesis, "M:I-2." "It's the most frustrating thing because the reviews all say that we are the better film," says Dey. "Yet people still keep going to the other one." We thought that's why they invented multiplexes.