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Pre-AP World History Composition
п»їGuptas vs . Muryans The Guptas and Muryans were both ancient civilizations that were located in India. The Muryans survived from around 323-185 BCE. The Guptas lasted…...Read
A counsellor can show his or her value to clientele in the next ways:
Acknowledge the client simply by showing complete, utter, absolute, wholehearted positive respect. This means that you as counsellor accept your customer as he or perhaps she is, regardless of the client's principles or conduct and of whether you while counsellor agree with those principles and behaviour or certainly not. A judgemental counsellor who have condemns clients or who also makes clientele feel that their sexual behavior is offensive to the counsellor, will not be able to facilitate curing, and will just do damage. Respect the client's legal rights. Individuals have a right to become who they are, the right to their personal feelings, philosophy, opinions and choices. Value the uniqueness of each consumer.
Refrain from judgement. Counsellors is there to help their very own clients, to never judge in order to blame them. Since HIVinfected individuals generally already think that they are " guilty" or " bad" before guidance even starts, only nonjudgmental attitudes on the part of the counsellor will facilitate understanding and growth. Continue to be serene and imperturbable without react with embarrassment, surprise or disapproval when people talk about painful scenarios or their sexual procedures with you. 2 . Genuineness and congruence
Genuineness refers to getting honest and transparent in the counselling romantic relationship. A genuine or perhaps congruent counsellor demonstrates the next values or behaviour:
Be yourself. Be real and sincere.
Be honest with yourself and your clients.
Need not patronising or condescending.
Maintain the client's plan in concentrate. Don't go after your very own agenda or inflict your self on other folks. Don't be defensive. Know your own pros and cons.
Strive towards achieving openness and selfп·"acceptance because these kinds of qualities will enable you to agree to people whose behaviour disputes with your own personal values. Remember that it is impossible to cover negative thoughts from clients. No matter how hard you try to conceal these people, clients will sense your incongruence. The moment clients...
п»їGuptas vs . Muryans The Guptas and Muryans were both ancient civilizations that were located in India. The Muryans survived from around 323-185 BCE. The Guptas lasted…...Read
August 26, 2012 Ethical Dilemmas Faced with a Profession Healthcare professionals frequently face complicated ethical issues in the workplace. These kinds of dilemmas often arise when ever employment commitments…...Read


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An early start from Pwllheli to calm waters, no wind. However, a good sailing breeze was welcomed and just awesome sailing.
Congratulations to Paul 'Sandpiper' for his Irish Sea crossing singlehanded, no mean feat.
Underpower, the motor yacht Papajena reached Greystones in FINE STYLE.
The Impromptu Cruise has been a great success, eight boats in all, making new friends, new achievements, and not to forget amazing wall to wall sunshine which makes all the difference.
Due to commitments, certain boats had to return to Pwllheli after the weekend. but boats also continued to Malahide.
A welcome picnic at Malahide Marina hosted by our Malahide Yacht Club friends was the 'icing on the cake.'
Glad that 'Concerto'also managed to join at Greystones mid week.
Individual comments were:-
Views of cruisers visiting Greystones for the first time:-
"The Marina and hospitality of the town was out of this world. The food was stunning at 'Hungry Monk'and the Italian 'Bachellis.'"
"The overall experience from the Marina Manager welcoming us , the coursciousness of all concerned inc. the welcoming experience in the restaurants."
"Ease of travel to Dublin, accessibility of everything. A good base an ideal starting location. Certainly somewhere to come again."
"Firstly, the sense of contentment due to the company made you feel part of a very lucky group of people. "
"Paul accompanying us on Papajena, as an extra pair of hands, crossing the Irish sea made a difference 'A great success.'"
Tina Maria, Alan and Gresham indulged, as they say, in the biggest breakfast,in the Cafe close to the Marina.
Mair and Dic on Concerto will be returning a.s.a.p to Greystones as their experience was such an enjoyable one.
The hill walk was a real challenge in the soaring heat, but some were fitter than others. The beach was also an attraction and one or two were brave enough to go for a swim.
Some boats were leaving on Monday so Sunday night was spent having a few drinks together in the Beach House Public House before everyone went on to their different destinations.
Malahide was the next destination. The children waving at us on the beach as we were coming up the channel followed by a welcome picnic at the Marina hosted by our Malahide Yacht Club friends was the 'icing on the cake.'
Our Malahide experience was outstanding, yet again. The Malahide YC making us welcomed using the Picnic Area at the Marina, where a BBQ could also be provided by the Marina. A wonderful afternoon eating away overlooking the Marina - what an unique attraction.
That evening we were escorted by Howth Members to a BBQ evening. The Irish giving us a top class welcome as usual.
Malahide town is so accessible from the marina and plenty of eateries covering all tastes not to mention the Restaurant placed overlooking the Marina. All provisions are available in the town. Beautiful walks to the well known Malahide Castle and also round the lake where most of the dingy sailing takes place.
Overlooking the Marina you find a fitness suite, ideal if you wanted to burn some calories after overindulging. No takers from the Cruisers on this occasion however.
We were warmly welcomed by the Malahide Marina Manager on our departure and we expressed our thanks for a fantastic stay. "We shall be returning a.s.a.p".
A GREAT Marina to visit on this part of the coast. A real wonderful experience in a picturesque setting.

subset: commoncrawl


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Most divorced parents in Illinois work hard to maintain cordial relationships with their children's other parent. Sometimes, however, tensions can erupt or situations become strained. This can be particularly true during custody exchanges, the act of one parent dropping the kids off at the other parent's home for parenting time or visitation.
The reason why custody exchanges can become tense vary between families. In some cases, the parents have unresolved emotions that tend to peak when both parties are in the same room. In addition, a parent who is dropping a child off at the home of the parent with physical custody may be resentful that the other parent has more time with the children.
Another possible reason for tension to be present during a custody exchange is because one parent may have become romantically involved or married to someone else. In such situations, jealousy may trigger strong feelings. Regardless of why it is occurring, conflict during custody exchanges can have a detrimental effect on children and may eventually lead to a custody dispute.
Since it's so important to create a stable environment for children, any animosity should be addressed right away. This may mean talking with a counselor or mediator who can help the parents resolve hard feelings and work together to create a positive climate for the kids. In very serious situations, parents may be required to alter the way they exchange custody. In the case of older children, the parents may decide to have no contact with each other during drop-off and pickup times.
Parents who are concerned about issues that arise during custody exchanges may want to speak with an attorney who is experienced in family law matters. A lawyer may be able to review the client's case and make recommendations regarding child custody modifications or other strategies for reducing tension and keeping them from escalating.


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Metal detectors reviews
About me
List of Metal Detecting Tips
I have compiled this list and it is by no means a complete list. This was put together by me reading lots of different forums and other sources. I think that there is some great info here for the newer detectorists and there might be something for the seasoned pro. So here it goes.
Read and adhere to the code of ethics, especially the part about filling your holes back in
Always re-check your hole after digging the initial target
Keep your coil close to the ground and level throughout the swing
Research-location is key to finding quality finds, and is key to being in the right place to find those targets
your detector
, knowing your lower-end detector in and out can out perform a better equipped hunting buddie
Don't get impatient and disappointed, you are not going to get rich quick, quality finds are generally proportional to time spent in the field and the number of holes dug.
Use the right coil, when in trashy areas use a small "sniper" coil, when depth is needed use the larger search coils. If the area is to trashy then focus on a small area and dig it all.
Always carry extra batteries
If you have an extra detector bring it, never know when you main unit might go down
Headphones, always use headphones to hear those faint and deep targets
Pin-pointer, can save you a lot of time and reduce the size of the holes you dig
Discriminate as little as possible, gold rings and chains show up as pull tabs and foil
Balance your detector often, or when you change your settings
Wear gloves to protect your hands from sharp objects
Watch people when at places you detect to see where they are and what they are doing. Not to be confused with stalking
Have a backup plan in case your site falls through
Water, keep water handy and drink a lot in hot weather
Use a probe to recover shallow targets
Carry a digital camera to document your finds
Never show anyone your finds, tell them "just pennies and junk" but always show them when on private land
Keep it safe, hunt with friends when in a not so safe place, tell family when you should be back give or take a couple of hours.
Test targets can provide you with an advantage when hunting a new area.
Cover your coil and control box just in case of potential down pour, and or to keep the dust out
Garden, having a test garden at home will give you the advantage you have been looking for, it will help you to learn your machine in ways you never thought possible.
Search grid, when at a new or even old hunting area, search it in a tight grid pattern, then reverse the pattern at a different angle.
Learn to pinpoint, when you master your pinpointing skills you will spend less time searching for your target
Search pattern, first two patterns at right angles to each other and then another one at a 45 degree angle to the first two
Check your target by sweeping over it at different angles
Knee-pads, they make digging a lot more comfortable
Keep a extra rag on your tool belt, to keep your digger, detector clean
Protection from the elements, such as a hat, sunscreen, bug juice, rain coat
Different digging tools to a new spot can save the day, you never know what you might run into
When hunting with partners bring a set of walkie talkies, they can save you a lot of walking back and forth
Prepare for your hunt with mapping it out, printing out maps, from such places as google earth, or yahoo maps, find out where old buildings used to be, and where people used to gather
On really nice lawns use a towel to put your dirt on and to ensure you are not making a mess
To help out with deep targets you can lift your coil six inches or so to see if the signal diminishes, if it does it might be can slaw
Always be aware of your surroundings, pay attention to everything not just your coil
Take a break once in awhile, give your brain, ears, and arm a rest they deserve it
Multi-tools come in handy, pick one up if you don't have one
Flashlight, deep holes even on sunny days are hard to see into
An old paint brush is a handy tool when you get back to your vehicle to clean off the days dirt form your detector
Keep special finds in a different place, an extra, small pocket in your "fanny pack", a different vest pocket, you won't like it if you best find gets scratched from a piece of trash in the same pocket. A pill bottle with some cotton in it will work wonders to save that gold, or silver.
Rings will give a response based on the thinnest part of the band
Necklace's with large enough links will give a chatter as the coil is passed over it
Think outside the box, put yourself in someone else's shoes when hunting a new spot, what would they be doing
Like I said this list is just some ideas, that I have gotten from other people on other forums, and other sources from around the web. If you have something you would like to add then please let me know.
Simple Facts About Metal Detecting
Pulse Induction Metal Detector
How to Choose the Best Metal Detector
4 Ways You Can Optimize Your Metal Detecting Skills
Prospecting for gold with metal detector
Best Cheap Metal Detector
Meteorites Metal Detecting
XP Deus Amazing in Trash
Fun Activities with a Metal Detector
Using Metal Detecting Clubs to Find More Buried Treasures
Metal Detecting Secrets
Acquiring Help For Your Interest in Signing Up For Metal Detecting Groups
Recordkeeping In Metal Detecting And Coin Shooting
Metal Detecting And Artefacts
What to know about search coils
The "B's" of Treasure Hunting
8 Tips for finding more lost treasure
The Thrill Of The Hunt
List of Metal Detecting Tips
Halo Effect Definition in Metal Detecting
How To Handle Coins (Coin Care)
Pricing Coins
How To Detect Fake Coins
Grading Coins - Coin Collecting Values
Coin collecting name - Numismatics
A Brief History Of Coins
Metal detectors – Buying the Correct One
Metal detector as a good investment
Replacement a battery of XP Deus using an one with bigger capacity
How to Research Treasure Tales
Prospecting In Michigan
Best Place For Metal Detecting
Metal Detector For Kids
Metal Detectors Working Principle
Types of Metal Detectors
Typical Native American Finds While Metal Detecting
The 3 Best Metal Detectors for Native Artifacts
Where To Go In the US to Find Buried Native American Treasure
Bounty Hunter Gold Digger: Perfect For Beginners!
Bounty Hunter Quick Silver Metal Detector
Three Best Metal Detectors for the Beach
Three Best Cheap Metal Detectors
XP Deus firmware update (from newest to the first versions)
Tips and tricks:


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Thanks to the non-stick titanium and ceramic coating of Gotham Steel, baking a cake, cinnamon rolls and other dishes has never been easier! This scratch-resistant pan helps your baked creations easily slide right out onto the cooling rack. Great for cakes, quiches, cinnamon rolls, monkey bread, scones and more! Dishwasher safe.
What is the size of the cookie sheet?
It measures 17.5" L x 12" W x 1" D.


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"How do I find cable near me?" shouldn't be the only question you're asking. You should also ask yourself if you can pass the credit check. Yes, most major cable providers ask you for a credit check. As US News & World Report warns, this could be a hard inquiry (the kind that can impact your credit). They must ask your permission first but be forewarned, if you don't consent you could end up paying a deposit.
For more package options (and more channels) with Charter Spectrum, you'll have to bundle with internet and phone service. Those bundles come at a fair price though, and include free installation (normally $35), WiFi set up (typically $10), and DVR service ($13 per month). That's a potential savings upwards of $200 in one year. Spectrum also includes HD channels free of charge.
You probably want amplification, unless you're living next door to the local broadcast tower. They don't make the signal stronger coming in the house; they make an already low signal strong enough for the TV tuner to use. Even some of the flat antennas have amplification options; but amplification ups the cost. Setup is easy, but you'll have to play with the antenna position to maximize reception—just like fiddling with rabbit ear antennas in the 1970s. Some outdoor antennas can work from inside if they're up high—say in your attic—if there isn't a lot of obstruction.
1 Number of available channels may vary by area. Please refer to your local channel lineup for details. An HDTV, HD cable box and HD cabling are required to view HD programming. HBO, Cinemax and related channels and service marks are the property of Home Box Office Inc., LLC. SHOWTIME is a registered trademark of Showtime Networks Inc., a CBS Company. Starz® and STARZ ENCORESM related channels and service marks are the property of Starz Entertainment, LLC. All other trademarks are the property of their respective owners.
Antenna: The antenna is the way TV started. You connect an indoor or outdoor antenna to your TV and receive programs from over-the-air local and network affiliate TV channels. This is a great way to receive free programming from the major TV networks (ABC, CBS, NBC, Fox, WB, and PBS). It is important to note that older analog TVs, and many HDTVs made before 2007, will require the use of a digital converter box that is placed between the antenna and the TV.
Satellite TV and internet work by transmitting data over radio waves. TV and internet broadcasters transmit radio waves to satellites and then, the satellite transmits the signal back to your receiving satellite dish. The dish passes the signal onto your TV and internet receiver, which processes the signal and passes it to your TV or computer for enjoyment.
DISH also has the best DVR available. The Hopper 3 Smart DVR lets you record up to 16 shows at once, and you can record 2 ½ times more HD content (500 hours) than the Genie from DIRECTV (200 hours). However, keep in mind that the advertised package price doesn't include the DVR price. You'll have to pay an extra $10 per month for the Hopper and an additional $5–$10 per month for each added receiver.
The question of "when does it make sense?" can easily be rephrased as "how much money can I save?" and one of the biggest factors will be the price difference between combined internet and TV service or just internet. These are also the options that vary the most widely based on where you live, and the availability of promotions or contracts that can keep prices down for a short time.


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Are you confident that your personal injury attorney in Kendall County has put your interests first ahead of a big payday? Will they do the appropriate due diligence and dot all I's and cross all T's when it comes to the paperwork and evidence needed to get you the settlement — and justice — that you deserve following your personal injury accident? At Carabin Shaw, we represent folks in the San Antonio, Texas area who have suffered a devastating personal injury due to an accident that wasn't their fault. We'll represent you with a tough-minded and thorough approach and won't see a penny unless and until you do.
Personal Injury Attorney Near Me In Kendall County Texas
At Carabin Shaw, we've compiled a staff of legal experts and personal injury attorneys designed to represent your interests in a personal injury claim from the initial phone call to our San Antonio office, the initial, free consultation, all the way through the process up to and including a trial and litigation, if necessary. Our exceptional team of personal injury attorneys are experienced and well educated in all aspects of personal injury law and the processes set up to deny, delay, and to keep you from the settlement and justice you deserve. Let us worry about your personal injury case in Kendall County TX while you focus on recovery and getting your life back to normal.
Free Consultation With A Personal Injury Attorney — (210) 503-9717
When you place a call to the San Antonio offices of Carabin Shaw's personal injury attorneys, you'll initially speak with a knowledgeable and friendly legal associate who can answer any of your personal injury case questions. Then you'll get a free consultation with one of our expert personal injury attorneys. So call us for a free consultation today at (210) 503-9717.
More About Personal Injury Attorney
Ways to Select a Personal Injury Attorney
Accidents in Kendall County that cause injuries are typically unforeseeable. They can happen anywhere and without warning. Therefore, the number of people impacted by accidents tends to come in thousands, if not tens of thousands.
In fact, the more access people have to cars and trucks and machinery, the higher the variety of casualties. Hence, personal injury attorneys are an asset to society because they help the victims with litigation; ensuring they get well compensated for their injuries and losses.
Personal Injury Claims Are Complex Cases
For a person who isn't really familiar with the rules and guidelines of filing claims, the process can be long and dreadful. You will have tons of documents to go through and lawyers from the other side fighting to make sure they squeeze out the smallest amount they can as compensation.
Every case in Kendall County is unique, so you can't utilize a similar scenario as a blueprint for how you should proceed. Particular actions are nevertheless comparable.
The first step of filing a claim would be a free consultation with the attorney. In this action, you should go over the case thoroughly, the nature of the accident, along with the degree of injuries sustained. The personal injury attorney will ask a series of questions relating to the case. It's also the opportunity for you to ask questions concerning the case; like who will manage it and how long it would take.
Comprehensive Investigation Of The Case
The personal injury attorney will carry out an extensive investigation. Depending upon the circumstances, the attorney will collect data from reconstruction experts, medical professionals, the police and other experts involved with the case. The process would consist of:
• Gathering reports from the police
• Evaluating the accident scene
• Assembling photographs
• Gathering testaments from witnesses
• Acquiring your medical reports
• Confirming the time missed from work due to the accident
These listed actions are not conclusive, but form a basis for examining the case. Your attorney will keep you informed throughout the process; responding to your questions and legal requirements.
Afterward, a demand for settlement will be sent to the pertinent insurance company, detailing the case and liability. The opposing party will examine the letter and either accepts conditions, make a counter offer or reject the demand.
Filing The Personal Injury Lawsuit
In case the opposing party's insurance provider declines the demand, a suit might be filed.
Your personal injury attorney in Kendall County TX therefore will prepare you for the court proceedings. It is possible for the other party to get the help of a mediator to avoid a claim. Mediation is an informal proceeding where the parties try to reach an arrangement. Your attorney thus should have experience in handling mediation processes. S/he will prepare you for it as well.
Actions Leading To Compensation
Therefore, whether the other party accepts liability or rejects it, an exceptional personal injury attorney will ensure that you get the compensation you deserve. Whether the litigation process is through a causal mediation process or a court trial, you will still be ensured of compensatory payment and comfort as you recuperate.
Cities We Serve In Kendall County
Learn More About Kendall County TX


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Chandra is senior features writer at PCMag.com. She got her tech journalism start at CMP/United Business Media, beginning at Electronic Buyers' News, then making her way over to TechWeb and VARBusiness.com. Chandra's happy to make a living writing, something she didn't think she could do and why she chose to major in political science at Barnard Co... See Full Bio
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In June 2017, Amazon announced that it would acquire Whole Foods, a high-end supermarket chain with over 400 stores, for $13.4 billion.[14][41] The acquisition was seen by media experts as a move to strengthen its physical holdings and challenge Walmart's supremacy as a brick and mortar retailer. This sentiment was heightened by the fact that the announcement coincided with Walmart's purchase of men's apparel company Bonobos.[42] On August 23, 2017, Whole Foods shareholders, as well as the Federal Trade Commission, approved the deal.[43][44]
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Charles K.Chui教授第三次受邀进行讲座
发布时间: 2018-10-25 14:20:22
题 目:Inverse Problem on Assessment of our Health and Well-being
报 告 人:Charles K. Chui 美国斯坦福大学
时 间:2018-10-25 10:00--11:00
地 点:学院401
Charles K. Chui教授是国际著名小波分析的专家,是世界多间著名大学的特聘教授,包括香港浸会大学、美国斯坦福大学、美国密苏里州大学和美国德克萨斯州大学等。已经出版数十本著作,发表上百篇论文,现在是国际著名学术杂志 Applied and Computational Harmonic Analysis(中科院一区)的主编。
摘 要:
Hormone balance is critical to our health and well-being, in that its imbalances commonly lead to fatigue, sleep changes, depression, loss of bone, hair loss, memory difficulty, heart disease, and cancer. Our endocrine system is in charge of secreting hormones, mainly from the endocrine glands to the blood stream, creating pulse signals that can be measured, most conveniently from our two wrists. Normal daily periods of hormone secretion are governed by the circadian rhythms. This lecture is concerned with the important inverse problem of assessing the health of the major endocrine glands from pulse data. Motivated by the published medical literature, we introduce a mathematical representation of pulse waveforms, with three parameters that govern the pulse strength, rate of secretion signal onset, and rate of secretion signal decay, respectively. We then formulate the mathematical model of the source signal in terms of the pulse waveforms, and discuss the inverse problem.


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In a quiet start to the trading week, global stock markets had a mixed day as investors remained cautious ahead of the crucial trade talks between China and the US. The dollar continued to drive higher with the Dxy gaining for the eight day in a row, now trading just above 97.00. The pound came under further pressure as GDP data disappointed with both the quarterly and yearly number both coming our lower by 0.1%. Commodities came under pressure with Oil hitting its lowest level for two weeks as global growth concerns weighed and traders eyed upcoming risk events in the form of OPEC and EIA market reports.
The same issues that have been driving markets for so long are still top of the list for investor concerns this week but there is some hope that we could get some further clarity by the end of trading Friday. The talks between the US and China are dominating sentiment and investors are hoping for some clear guidance from both sides with the March 1 deadline for tariffs approaching. Brexit concerns continue to weigh on local markets and currencies with the EU standing firm on it's original deal and Theresa May crossing the channel attempting to find a solution that works for both the EU and parliament, so far little progress appears to have been made and the possibility of a hard Brexit increases. In the US, another government shut down is looming with tensions rising on the political front as we approach the Friday deadline. Investors are hoping that we get some clear guidance from the various parties involved in the above issues that will enable them to make informed trading decisions and as various deadlines approach there is a chance of this occurring this week, although possibly not with the outcomes that many would want to see.
Today's trading sessions are once again light in terms of fundamental economic data releases but we do have some heavy hitters in terms of central bankers set to speak and this could lead to some significant moves in the market. German Buba President Weidman is first up in the London session followed a few hours later by the BOE Governor Mark Carney. Probably superseding these two much later in the trading day is Fed Chair Jerome Powell as he delivers a speech in Mississippi.


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Search Jobs
Principal Scientist - Waltham/MA or Bridgewater/NJ
Waltham, Massachusetts, Bridgewater, New Jersey
Job Summary
Provide bio-marker support to progress drug development programs, initially focused in hematological diseases. The incumbent is expected to oversee routine and complex bio-marker experiments conducted in internal or external laboratories. This includes bio-marker assay development, troubleshooting and validation, quality checking of data and return of data and reports to project teams. The incumbent will promote the conduct of experiments with high quality and within expected timelines. Incumbent is expected to contribute to plans for quality bio-marker sample collection, shipping, banking and analysis. The incumbent will act as a resource for current and emerging bio-marker technologies. Participation in TMED Working Groups and project team Translational Medicine groups is expected.
Essential Job Duties and Responsibilities
- Must have a thorough understanding of standard and emerging bio-marker assay technologies for development and validation of complex assays, including capability to identify potential issues and trouble-shoot assays when problems are identified.
- Assist project teams on selection of best assay technologies to support project objectives, with subsequent implementation of those technologies.
- Serve as BCB Lead to support project teams with bio-marker activities.
- Contribute to achievement of team bio-marker objectives with high quality and within timelines. Develop productive relationships with personnel in internal and external groups involved in bio-marker activities.
- Provide scientific input and oversight on bio-marker sample collection, shipment and storage, sample analysis, and return of data.
- Contribute to high quality, timeliness, and following of regulatory requirements with internal laboratories and external service providers.
- Participate in meetings and other activities of project teams, CTTs, working groups, and other relevant groups as needed to contribute to projects.
- In support of projects and innovation, assist BCB, TMED and other groups regarding biomarker-specific scientific, operational and regulatory issues and opportunities.
Required Educational Background and Job-Related Experience
- Ph.D. in biochemistry, immunology, pharmacology, genetics, bio-analytics, or related scientific discipline with 5 or more years of industry experience, or a Masters Degree with 7 or more years of experience.
- Experience with bio-marker assay development and validation, especially for large molecules or nucleic acids.
- A diverse skill-set in bio-analytical assay development methodologies such as ligand binding (ELISA, MSD, etc.), multiplexed bio-marker analysis, and enzymatic activity assays.
Knowledge and Skills Required
- Strong interpersonal and organizational skills.
- Familiar with regulatory expectations (FDA, EMA, Asia-Pacific) and industry best practices in analytical assay development and validation of bio-marker assays.
- Strong desire to continue to develop scientific expertise in bio-marker technologies and utilization in drug development.
Knowledge and Skills Desirable but not Essential
- Emphasis on development of treatments for hematological diseases considered a plus.
- Prior experience serving on drug development project teams.
- Experience with bioinformatics, quality, regulatory, outsourcing, or drug development.
- Experience with small molecule drug metabolism and pharmacokinetics.
- Experience with pharmacogenomics.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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More than 10 million operations and procedures are performed each year in the UK. Weighing up whether to go under the knife is a major decision, and doctors need to play a supportive role in making sure that patients are fully informed about the risks and benefits of undergoing a treatment.
Authored alongside Aliya Mackenzie and Natalie Farmer. First published in the Student BMJ.
Obtaining consent for a procedure is one of the core competencies for graduates expected by the General Medical Council, and is a common scenario in medical school objective structured clinical examinations (OSCEs). In this article we offer guidance on how to take a patient centred approach to sharing information about a procedure and obtaining consent.
What is consent and why is it important?
The law states that patients have the right to determine what happens to their bodies, which means that performing a procedure on a patient who hasn't signed a consent form is a form of battery and can lead to criminal charges. In the past, the consent process has sometimes been paternalistic, with surgeons recommending their preferred option and patients following in tow.
In 2015, a landmark decision by the UK Supreme Court in the Montgomery v Lanarkshire Health Board case prompted a change in the law. The court ruled that doctors must now take "reasonable care to ensure that the patient is aware of any material risks involved in any recommended treatment, and of any reasonable alternative or variant treatments." Previously, doctors could decide what to tell patients about the risks and benefits of a procedure, and their actions would have been judged only against other doctors' opinions of what information should be shared with the patient (known as the Bolam test).
Since the Montgomery ruling, however, doctors must not make assumptions about which risks are important to patients and must fully disclose any risks that may be of particular importance or relevance to that patient—for example, a professional singer undergoing a throat operation. The Montgomery case prompted the Royal College of Surgeons to publish new guidance on consent, Consent: Supported Decision-Making which emphasises the role of surgeons in assisting patients to make a decision on whether a procedure is right for them rather than the traditional paternalistic model where a surgeon's preference would often be presented to patients as the default option. By using shared decision making, it is hoped that patients will be more informed about treatment options, and that this will reduce the number of errors, complaints, and misunderstandings.
Ideally, the consent process should take place over a period of time to allow patients to understand their treatment options.
Who can give consent?
For consent to be valid, the patient must have capacity, give their consent voluntarily, and must understand the information given to them about the proposed treatment. If a patient does not speak English, a trained independent translator should be used. For children and patients who lack capacity, the process is different. Children under the age of 16 may be considered Gillick competent to make treatment decisions on their own.10 If a child is unable to give consent, then a parent or guardian will usually do so.
An adult patient is deemed to lack capacity if, despite support, they are unable to retain, understand, and weigh up information about a procedure. If their impairment is temporary, the consent could wait. If a patient is unable to give informed consent, decisions must be made in their best interests, with input from relatives, your colleagues, or by an advance directive.
What if a patient refuses consent?
Patients have the right to refuse treatment, provided they have capacity. They should be made aware of the likely consequences of their decision, as well as alternatives.
Who should obtain consent?
Consent should be sought by a doctor or surgeon trained to perform the procedure, but the process may be delegated to another consultant or registrar. As a foundation doctor, there will be several procedures for which you will need to obtain verbal consent, but it will be uncommon for you to carry out procedures that require written consent (there are some exceptions, such as HIV testing).
As a junior member of the team, you can spend time with patients to check their understanding of the procedure. Patients experience better outcomes when they feel supported.
Documenting consent discussions
Before an operation can go ahead, a consent form must be completed. Having a thorough discussion with patients can minimise the risk of later medical negligence claims.
Recap - The process for obtaining consent for a surgical procedure
As a medical student, althoughyou will not be responsible for obtaining consent, you can observe senior doctors following the consent process:
1 Explain the diagnosis
Check the patient understands their diagnosis, the findings that have led you to this diagnosis, and their prognosis if left untreated. Gauge what the patient already knows about their condition in order to clarify any misunderstandings.
2 Explain the supported decision making process
Reassure the patient that the consent process is a shared decision, that you will support them through it, and that they can withdraw their consent at any time.
3 Understand the patient's wishes, needs, views and expectations
Do not make assumptions about what is a "good" outcome for a patient. Ask them what matters to them. Different patients have different priorities, perspectives about what constitutes a material risk, and what risks are acceptable. Also, in this discussion you might learn about their fears, important family relationships, or previous clinical experiences that might influence their decision.
4 Discuss the treatment options
Explain the various options and the key risks, benefits, and outcome data of each, including opting for no treatment. Raise any material risks or complications that might be relevant in order to understand the significance the patient attaches to them. Individual patient risk should also be covered—for example mortality and complication risks—which will be based on several patient factors such as cardiovascular health, obesity, and age.
Discuss trade offs with the patient in light of their needs, goals, and expectations. Explain how different options might help them achieve their goals and the potential impact of the options on their short and long term quality of life.
5 Check the patient's understanding
Assess the patient's understanding of the discussion so far, so that you can address any misunderstandings or further questions. Ask patients to relay what they have understood using a technique such as "Teachback," 13 or similar, and check whether there are any further questions or concerns.
6 Give the patient time to think about their treatment options
Give patients time to consider their treatment options and goals. A decision to consent is usually not made in one sitting or on the spot. Provide the patient with resources on their condition and on treatment options for them to read in their own time.
7 Coming to a decision
The patient should state their choice of treatment and there should be a detailed explanation and time for questions about the procedure chosen. The patient should leave a consent discussion feeling as supported as possible.
8 Respect the patient's decision
Respect the patient's decision and remind them that signing a consent form is not a point of no return—their consent can be withdrawn at any point if they change their mind.
9 Signing the form and maintaining a decision making record
A consent form should be co-signed by the patient and doctor, with one copy put in the medical notes and another given to the patient. The discussion surrounding the procedure should be documented in the notes, with a record shared with patients. On the day of the procedure it's essential to confirm and countersign that the patient remains willing to proceed, and to answer any final questions.


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Garage Door Balance TestIndustrial Garage Doors Roll Up
This image gallery named as Garage Door Balance TestIndustrial Garage Doors Roll Up might be ideal solution for your decoration. As the author has insert this image into Balance Garage Door post section, would ease you to find the perfect match of you decor desire.
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Animation Director's Reel 2017
Shots gathered from Disney's Elena of Avalor that I directed and partly animated. I have a team of 11 animators ranging from junior to lead skill level. Heavily featuring song "Can't Catch Me" which has brought in over 10 million views.
T.V Reel 2018
Animation clips I have gathered from episodes of Elena of Avalor
Responsible for all animation & camera work & direction in Elena of Avalor shots.
All rights reserved to Disney.
T.V Reel 2016
Animations I have gathered from episodes of Goldie & Bear
Responsible for all animation & camera work.
All rights reserved to Disney


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Good Morning, ! Today is Wednesday, October 9 Thank you very much, Cookie! My lawn is bright yellow. Completely covered with bright yellow leaves. Around here that does not mean anybody would go buy a rake and garbage bag, except maybe the newcomers in the new subdivision. Most people just look to the Western horizon and guess about when the next Chinook will arrive. The climatologists had predicted a Chinook for the weekend, but with those bozos you got to be glad if they can correctly predict that after Friday there is a good chance for a weekend. They are still yapping about Gullible Warming. Yeah, right. Down South, maybe. Here we had two degrees above freezing, thin November rain and a gusty 20 - 40 mph North-West wind while I took Copper, my neighbor's dog, for our regular evening walk. Tomorrow I will be wearing gloves! Have FUN! DearWebby
If you can help with the cost of the Humor Letter, please donate what you can!
Talking much about oneself can also be a means to conceal oneself. --- Friedrich Nietzsche (1844 - 1900)
>From Dave Morris Schwartz is dying and is on his deathbed. He is with his nurse, his wife, his daughter and 2 sons, and knows the end is near. So he says to them: "Bennie, I want you to take the Beverly Hills houses.' Sybil, take the apartments over in Los Angeles Plaza. Hymie, I want you to take the offices over in City Center. Sarah, my dear wife, please take all the residential buildings downtown" The nurse is just blown away by all this, and as Morris slips away, she says to the wife, Mrs. Schwartz, your husband must have been such a hard working man to have accumulated so much property." Sarah replies, "Property schmoperty...the schmuck had a newspaper route."
Stink Bug Control! (This is NOT about the Government!) In Alaska, don't worry about stinkbugs, yet. So far they are only in the lower 48 states, and worst in the East. If the stinkbugs have started to show up in your area, get this book! The price WILL go up, so don't procrastinate! Get StinkBug Control now!
>From Dave A Jewish couple won twenty-million pounds on the lottery. They immediately set out to begin a life of luxury. They bought a magnificent mansion in Knightsbridge and surrounded themselves with all the material wealth imaginable. Then they decided to hire a butler. They found the perfect butler through an agency, very proper and very British, and brought him back to their home. The day after his arrival, he was instructed to set up the dining room table for four, as they were inviting the Cohens to lunch. The couple then left the house to do some shopping. When they returned, they found the table set for eight. They asked the butler why eight, when they had specifically instructed him to set the table for four. The butler replied, "The Cohens telephoned and said they were bringing the Blintzes and the Knishes!"
Sun in my neighbor's poplar tree Click on the picture for the large version and here with the sun behind a branch Click on the picture for the large versionIf you like the Dear Webby Daily Humor Letter, please vote for it at the Ezine Finder: Thanks for your votes! Voting works again!
An INTERNATIONAL BONEHEAD AWARD goes to April Chamberlain, 30, Oklahoma City, OK Teacher jailed for passing out drunk at school with whisky in purse Reported by The Weekly Vice April Chamberlain, a 30-year-old substitute teacher at Milwood High School, was jailed Wednesday after she was allegedly found passed-out drunk with a bottle of whiskey in her purse. According to the Oklahoma County Sheriff's Office, Chamberlain was substitute teaching a biology class while she appeared disoriented and persisted in using profanity with students. When students found Chamberlain passed out in the office, they contacted a coach who alerted the school principal. Investigators say Chamberlain was slow to wake up after she had been tapped on the shoulder and shouted at to "wake up." A deputy at the scene found an opened bottle of Canadian Whiskey in Chamberlain's purse and noted that she smelled strongly of alcohol. Chamberlain also reportedly slurred her words and appeared to be unsteady on her feet. She was booked into the Oklahoma County Jail and charged with public drunkenness. Following the arrest, Millwood Public Schools Superintendent, Cecilia Robinson, announced that Chamberlain was "only a substitute teacher".The link to Mail Washer is here!Tech Support Pits From: Jan Re: Free Anti-Virus Webby I was wanting to know IF you knew of any Free Anti Virus that was really good and did the job of protecting, I at times can not afford the ones like you use etc..and all. May sound strange but that's the way it is for me .. I want some thing that Can do the job and be trust worthy and thought you would be the one to know. Thank you so much and I hope you are doing ok with your eyes .... Jan Dear Jan If the free ones were good enough, then nobody would spend $30 a year for a better one. Depending on what one has to protect, an empty KFC bucket might be good enough for a motorcycle helmet. Personally, I prefer a BELL helmet. Full face. That is why I use McAfee McAfee Total Protection has all kinds of other goodies included. For example, if somebody sends me a link, and there is some kind of danger there, It pops a big, goofy warning screen with 2" high letters yelling: "WHOA! Don't go there! Back up!" and it blocks that site from sending anything, even cookies. Like that, it has all kinds of protectors built in, not just virus and malware protection. You just have to decide, whether your stuff is worth $30 - $40 a year, or whether it is no big deal if you lose it all and it is easy enough to start all over. If you decide to gamble, upload the important stuff to some cloud based archive. There are some free ones available, though I have not checked those out. Have FUN! DearWebby
Daily tip from Thriftyfun.com Give Halloween Pencils Instead of Candy For Halloween I give out Halloween pencils. You can get them at the Dollar Store, there is usually 10 in a package. They always get too much candy, and it can be used after the holiday. The kids love it, so do the parents! I have been doing this for years now. By Lynda (crabby) from Kearny NJ Check out ThriftyFun's Blog
Some people grow old gracefully, while others fight and scratch the whole way. Andy's wife, refusing to give in to the looks of growing old, goes out and buys a new line of expensive cosmetics guaranteed to make her look years younger. After a lengthy sitting before the mirror applying the "miracle" products, she asks her husband, "Darling, honestly, if you didn't know me, what age would you say I am?" Looking over her carefully, Andy replied, "Judging from your skin, 20; your hair, 18; your eyes, 16, and your figure, 25." "Oh, you flatterer!" she gushed. Just as she was about to tell Andy his reward, he stops her by saying: "WHOA, hold on there sweety! I haven't added them up yet!" Andy may eventually be able to walk again, if he is careful.
Little Johnny was in church when the wine and wafers were passed out. His mother leaned over and told him that he was not old enough to partake in the Communion. When the basket was passed around she leaned over once again to tell him to drop his money in, but Little Johhny held his dollar firmly in his hand, stating: "If I can't eat, I won't pay!"
Ophelia Dingbatter's News
No sermon and not suitable for church, just jokes and fun for grownups. Read it on-line or subscribe. If you subscribe, look for the double-opt-in confirmation request.
» Captivating Black And White Photography
Today, Oct 9, in 1635 Roger Williams, founder of Rhode Island, was banished from Massachusetts because he had spoken out against punishments for religious offenses and giving away land that belonged to the Indians. Williams had founded Providence, Rhode Island as a place for people to seek religious freedom. 1701 The Collegiate School of Connecticut was chartered in New Haven. The name was later changed to Yale. 1776 A group of Spanish missionaries settled in what is now San Francisco, CA. 1781 The last major battle of the American Revolutionary War took place in Yorktown, VA. The American forces, led by George Washington, defeated the British troops under Lord Cornwallis. 1812 During the War of 1812 American forces captured two British brigs, the Detroit and the Caledonia. 1855 Isaac Singer patented the sewing machine motor. 1855 Joshua C. Stoddard received a patent for his calliope. 1858 Mail service via stagecoach between San Francisco, CA, and St. Louis, MO, began. 1872 Aaron Montgomery started his mail order business with the delivery of the first mail order catalog. The firm later became Montgomery Wards. 1876 Alexander Graham Bell and Thomas Watson made their longest telephone call to date. It was a distance of 2 miles. 1888 The public was admitted to the Washington Monument for the first time. Currently the pbulic is blocked from it. 1914 During World War I, German forces captured Antwerp, Be. 1936 The first generator at Boulder Dam began transmitting electricity to Los Angeles, CA. The name of the dam was later changed to Hoover Dam. 1940 St. Paul's Cathedral in London was bombed by the Nazis. The dome was unharmed in the bombing. 1946 "The Iceman Cometh" opened in New York City, NY. 1946 The first electric blanket went on sale in Petersburg, VA. 1963 Over 2,000 people were killed in northeast Italy when the Vaiont Dam was overrun by water. The incident was caused by landslide that occurred behind the dam. 1967 Che Guevara was executed by Bolivian soldiers for attempting to incite a revolution in Bolivia. 1975 Andrei Sakharov was awarded the Nobel Peace Prize. The Soviet scientist is known as the "father of the hydrogen bomb." 1983 Helen Moss joined the Brownies at the age of 83. She became the oldest person to become a member. 1985 The hijackers of the Achille Lauro cruise liner surrendered after the ship arrived in Port Said, Egypt. 1986 U.S. District Judge Harry E. Claiborne became the fifth federal official to be removed from office through impeachment. The U.S. Senate convicted Claiborne of "high crimes and misdemeanors." 1986 The musical "Phantom of the Opera" by Andrew Lloyd Webber opened in London. 1989 The official Soviet news agency Tass reported an unidentified flying object. The report included a trio of tall aliens that had visited the city of Voronzh. 1994 The U.S. sent troops and warships to the Persian Gulf in response to Saddam Hussein sending thousands of troops and hundreds of tanks toward the Kuwaiti border. 1995 Saboteurs tinkered with a stretch of railroad track in Arizona. An Amtrak train derailed killing one and injuring a hundred. 2009 NASA launched the Lunar Crater Observation and Sensing Satellite (LCROSS). On November 13, it was announced that water had been discovered in the planned impact plume on the moon. 2013 smiled
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