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Crazy Little Bets
When i started following the advice he shared on his morning report, my profits increased a lot. Learn a lot from a little. Crazy little bets is a remarkable betting system that wins big with only a small amount of money placed as a bet. The first step was to develop a basic design for a silva cell system, request a quote for those materials, and request an installation estimate from our contractor at republic square. Seeking out a small group of these active users with little bets is a proven way to tap into unique insights and desires. A lot of hollywood imagination went into the movie.
My year, we had to sit out on the porch, because the mansion was undergoing some renovation. This thing called love, i just can't handle it. Which is a violation of union rules). After being convinced about the reliability of crazy little bets, if it happens that you are in search of an affordable channel to acquire crazy little bets, this website is an ideal option. Bet 1pt on this one. By his faith noah condemned the rest of the world, and he received the righteousness that comes by faith. I mean the instructions were. My hope is that people, if they want to innovate within theirorganization, even if its just reinventing a meeting, that they canmake a little bet to see how to do it better. There are several ways you work the system, and they begin with:. Interest has been strong for the three to five spots unruh envisions having in the incubator.
How do i make a payment. I do 10 with both legs on the ball. Ashley puts a no more than £6 on the horses each day. What's more, richmond has an evolved transportation network served by three interstates, and its residents enjoy a parks system that dates back to the mid-nineteenth century. It is not about not caring about failure. ",each of them consumed with their own uncertainties, their own dramas, yet for the first time realizing that they didn't need to face the future alone. Bush would win the 2000 presidential election. Father should be decently built, preferably athletic, with hair, and well equipped. In recent years hmd global has cemented itself as king of the mid-range smartphone, with its nokia-branded devices typically packing slightly slower processors, smartly balanced zeiss camera lenses and the absolute latest android software straight from google. I will put my money (and time) on the table and bet that this restaurant that i pick will be great.
Kids don't have the self censoring part of they're brain well developed. The centrepiece is the ocean zone, which has an immense ocean tank inhabited by sharks and tropical species, and a touch tank where little ones can find out what rays' backs feel like. I'm a crafter at heart and a girly girl. Grant that this day i fall into no sin, neither run into any kind of danger; but that all my doings, being governed by your will, may be righteous in your sight. If you are having delivery issue, please submit this in the report a delivery issue area of the site or click here. We would all be better off if every government, every nonprofit, every funder, put a tiny share of its budget -- my first guess, less than 5 percent, or maybe no more than you spend on office supplies -- and put that each year toward one carefully chosen little bet.
Carol dweck who is a professor atstanford. Turns out alex and lucy were about to have an affair and lucy planned to get pregnant and pass the child off as his. I think, for example, that the. And permanence creates both a barrier to starting ("another program. It takes you just a few minutes every day to place your bets. Among the most popular forms of gambling, after the national lottery, were betting on horse races and playing the slot machines. Its touching distance of d. The woman who wrote for a newspaper 25 years ago on trash paper and a manual typewriter writes this on a glass screen that she holds in one hand and brushes with a finger. Greveill one guinea the empress marie louise is in paris before emperor napoleon is in her person.
Her celibacy vow was more important even though she was celibate for only nine months she kept on with the lie to the hundreds of people online. Define: use insights gathered throughout the process to define specific problems and needs before solving them, just as the google founders did when they realized that their library search algorithm could address a much larger problem. Truly this system changes the way of thinking that most punters have. The burden shouldn't be on me. Chris dobrowolski has come in as the menu and kitchen consultant to create the dishes, explained cook.
Seeing the writing on the wall, both gavin and chris cashed in early, deciding the buy out of the bet. I sat in my quiet office today asking the lord these questions; my. • unlimited digital access: readers logged in to a morning call account that has been linked with an unlimited digital acccess subscription have access to everything on themorningcall. Mr genn, thank you so much for the video on painting is tribute…it makes me feel so much better about the art i have created in my many years past and plan to do future. More especially horse racing betting sometimes people lose terribly and think that it is all a complicated thing; which is not. Our hearts go into making each and every item. The sopranos need to insist that tony soprano died on-camera in the finale even though he absolutely didn't.
My head is constantly ticking over with ideas. Never in my life would i look at the relationship i have with you, my daughter, as human capital that i could convert into money. As this was a domestic flight, i didn't have lounge access included in my first-class ticket. "she finds wool and flax and busily spins it. "you will lose this bet". Crazy ex-girlfriend finale that i didn't love. The plan outlines the long-term and short-term development recommendations for the city's transit network. Like games from novomatic, bally wulff slots are easy to play and feature no-nonsense graphics and gameplay.
(evanston express uses one 6-car ravenswood train in the. He didn't really think they were failures, those unsuccessful attempts allowed him to eliminate what didn't work. "it's a great day. In addition, your device may have problems if private browsing is turned on or javascript is turned off. Or who knows what happens with josh. So without wasting any more of one's precious time just go for crazy little bets now. In that little bets cycle, in the agilecycle, the one thing that i question a little bit, though, is its alsothat check cycle when you get feedback. You betting will be straightforward and secure. And that barely scrapes the surface of the weird and wonderful bets british people have made "" here are few of the strangest, most outrageous bets to come out of britain in the last few hundred years:. Establishment of a small yard there), many north-south express trains.
" they learn and uncover opportunities as they go. Your credit score, on the other hand, describes your financial health in one tidy number. The dwarfs were always an important part of the story, but they didn't have individual names (apart from one stage adaptation) until walt disney came along. I pulsated like crazy in her hand as she rubbed my balls now as well. Purchase your buddies some haribo sugar free gummy bears. ' i think that gives their whole romance a reason for being. Redefining problems and failures as opportunities focuses our attention on insights to be gained rather than working about false starts or the risks we are taking.
Just seeing my dick lodged between those two things was enough to make me go crazy. The pergola da foz was installed in the 1930s as the mayor's wife fell in love with the one on the promenade des anglais. My daughter was laid out in a tight camisole and cotton pajama pants, the edge of her midriff was on display. This time i can bring my paints. Its a case of not always doing for those 500/1 bets as they will very rarely come in. The 6-foot-5 grimes had an up-and-down first season in lawrence as he went from a very-hyped mcdonald's all-american into an inconsistent player.
"jonathan climbed up, using his hands and feet, with his armor-bearer right behind him. Crazy little bets forces you to look smarter and younger thereby it rejuvenates you make you gaze more energized and healthy. If you're targeting a score that will help you negotiate a better rate on your car insurance, for example, myfico offers specific suggestions about how to get you there. No sodium, no sugar, sugar alcohol, additives, etc nothing. It had never been inside. A proper written notice will be a clearer sign of where things stand between the ncaa and these schools as we can only speculate on the investigations until they actually begin. Marcus is upset and betrayed, he gets angry and doesn't talk to lucy.
This was worse than what they had done to me earlier. Now they had me trapped. Cloud (showcasing his fetish work and private shows), strippers in the hood (showcasing his public performances with other male strippers), and strippers in the hood xxx (featuring private strip shows that lead to full on sex with the ladies). Felt, that this was still true. It was influenced by many,many other fields like advertising and other fields where theyhave creative processes.
Through to central (and later linden). My name is ashley cannon and a few years ago i was probably betting like you are now, you sign up with a tipster, follow a "system" or make your own selections, or a mixture of all of those, and you put a regular stake down on the bet. After that, you'll make your bet. History diehards will know the battle of chantilly went down here, a battle that plays into the historic heritage of this beautiful town. (southbound in the am and northbound in the pm only), wilson. Cars at the time and express trains made all stops between linden.
Little bets concept, which i really admire. Questions are the new answers. The whole experience — again, music aside — was certainly thought-provoking and easily the most spiritual and communal moment of the two weekends of this year's coachella festival. Explore feudal japan with our shogun's secret crazy chicken shooter slot review. Catch the tram out from the centre of gothenburg to töpelsgatan and then walk another few minutes to this pair of lakes (lilla and stora delsjön) enveloped in dense woodland. I don't think i am with you heart and soul. Though our write-up for this side quest is brief, rest-assured that this is one of the more difficult and arduous side quests in the entire game, and one that shouldn't be undertaken until you're strong enough to take care of business with little trouble (being level thirty doesn't hurt). This half wall had another mesh pocket, but it was too small to hold much.
Crazy little bets is surely an holistic approach. (1) head to the summit of black mountain and end tabitah's reign of terror. "i knew guys in college that drunkenly whacked off to the stuff and bragged about it. She goes to inspect a field and buys it; with her earnings she plants a vineyard.
Crazy Little Bets
A spasm shook every inch of my body. Twenty bucks worth of diabetic stuff at walgreens. Wealth has been created from horse racing betting. On the other side of the globe, a prankster in brisbane, australia, listed the nearby country of new zealand for auction on ebay in 2006. You'll be kitted out with safety gear will be attached to a safety line, before inching your way up the arch beneath the road crossing. Step 2: click the button below to download crazy little bets.
He got intowhat he calls "the worms eye view" and you just follow him as hegoes house by house asking people what their lives are like. Accessing crazy little bets also means that you are offered lifetime access to our members area which gets updated on a daily basis with helpful video presentations. I think we really got josh to a great place, from being a complete cipher like he was in the beginning, which was just an object for her to project on, to a guy who's trying really hard to figure himself out and has really come a long way. Crazy little bets is usually referred to as the shortest way to succeed. Broad city finale was a celebration of the show's two-headed solipsism, that in the most vibrant city in the world — the show's perspective, not necessarily mine — things always only revolved around ilana and abbi. My cardio is getting better each day. Good morning, vietnam is a 1987 american comedy-dramawar film written by mitch markowitz and directed by barry levinson. "honestly, we made the finale, and we did a concert special, and a documentary, which is insane. While skip-stop service was also introduced at this time, evanston trains continued to make all stops at their stations. Wedged in between the toilet and the bathtub was a top-of-the-line air mattress.
Other major cuts came at the expense of the human resources department (whose budget will fall from $9 million to $8 million) and student intervention and support services (from $2. ' it comes full circle, literally, from the scene in the pilot, and for me, it's why paula is in the show. (ap) — michigan's charles matthews, iggy brazdeikis and jordan poole are declaring for the nba draft, although they can still come back to the wolverines. But that are extremelyeffective ways to come up with numerous possibilities that, again,you cycle back through this process of testing. And he's the one who's the most distressed, really. Caffeine makes food taste less sweet. Such a basicthing that he used to become the largest automaker in the world. Even though the bet was ivey's idea to start with, he seemed less than confident that he could win the bet:. For a variety of reasons, nuclear power has been benched and is currently contributing a lot less than it could to our global energy needs.
But for me, just like for everyone else in the growing chorus singing from that hymnal, this picture hasn't come into focus yet. She couldn't look me in the eye when she said it. I writhed on top of her in orgasmic ecstasy and invaded her mouth with my tongue as i continued gushing into her pussy. Crazy little bets says all you need to do is place $1 to $3 bets, and you will make a profit. However, can a company avoid big bets.
00 max bet should keep bally wulff slot fans happy. A mindset that places to much importance on getting things right at the start that blocks ourselves off psychologically and chokes us off a host of opportunities. It scours your credit reports routinely, alerting you via phone, text, or email of any changes to your credit score. This system is going to provide you with strategies that you will just spend a few minutes a day to place your bet and there you are done. You can make as much as you want using this betting system. For me, business should be made of few big bets and many little bets, but i still can't see how we avoid big bets.
This will save you time and give you enough information to place your bets. Improvise, test, iterate, and repeat. And when your score does go up, you're notified right away — great for those of us motivated by positive reinforcement. Let your holy angels have charge of me, that the wicked one have no power over me. The eight tvs will be showing sports, including football on sundays, cook said. By buying crazy little bets anyone can buy one more package of crazy little bets for no extra charge. Rather than just give you the.
And everything else you can think of. That drops the total layoff number to 244, which is still problematic. Just the importance of getting out intothe world and out of the office and really, from the very, veryfront line. The third bet by antonio sought lodden's opinion of laak's poker prowess on a scale of 1 to 100. Because of this, the 2,000-person town of longyearbyen has made it illegal to die or be buried there. Betting is exciting; it leaves butterflies in your stomach as you watch the race. Peter sims: chris rock's little bets. 1 offers a bigger and nicer screen, much better performance and improved cameras for its extra $200, which is an attractive proposition. In season 6, the talk turned to prop bets and brought out the "gambler" in high stakes pros, phil ivey, tom dwan, gus hansen, daniel negreanu, and eli elezra. On hawaiian airlines' newest nonstop, from boston to honolulu, on what is now the longest us domestic flight in history, this isn't the case.
Healthy perfectionism is internally driven in the sense that it's motivated by strong personal values for things like quality and excellence. It will update you on all the analyses and instructions of each days bets through your email. [2] the picanto is primarily manufactured at the donghee joint-venture plant in seosan, south korea,. I cannot thank him enough for his help along to way. With all that in mind i would exercise caution with crazy little bets as i'm not entirely convinced you'll do well off it. Juney smith as phil mcpherson. We found that to be a pattern that we saw in the innovators,whether it was frank gehry or chris rock or jeff bezos, they allhad a growth mindset. Morningstar is the perfect service if you believe in fundamental/value investing. Before finding out about the morning line service, i used to bet on outsiders and other horses that didn't have a chance to win. Before that, i was in venturecapital, where i worked with summit partners, like growth equityinvestment firm, meaning, we invested in companies that weregrowing, profitable companies, companies that oftentimes beenbootstrap, self-funded by the founders, to the point where theyhad, say, 10 million in revenue or more.
Hour was barely a dozen people deep. Just click around the order button below and grab your crazy little bets in conjunction with two complimentary products which can be totally free of cost. Financially we were still in peril, but the dark cloud had lifted a bit. If you feel that simplicity of instructions and superior quality are the greatest assets of a product, crazy little bets is sure to be your first choice. So both of us made a bet on a basketball game, where the loser had to shave his head. The local magistrate there, however, respecting the rules of the bet, allowed bensley to be tried as "the man in the iron mask" and he got off with a fine. It's supported by timber and steel, but, should another earthquake hit, this transitional cathedral is flexible enough to remain standing. They are cheering both for the winning horse, but for the fact that they placed crazy little bets on the winner. Hi, my name is melissa and i'm the founder of little annie-bets.
"have you actually done it. The must-read summary of peter sims' book: "little bets: how breakthrough ideas emerge from small discoveries". Businesses that remain successful for the long term continually look forward. [but] she wasn't leaving any of them for the other ones. As i said i don't bet more than £6 per day. Punters spend hundreds of pounds on betting where one just subscribes to a tipster. On weekdays, service operates every 15 minutes early morning and night, 12 minutes middays and late afternoons. "hey, i'm talking to you stupid kid. Hes looking to see ifsomebodys shrugging or smirking or smiling.
There were no personal air vents, though, and the cabin ended up being pretty warm by the end of the flight. It is extremely easy to order and avail crazy little bets. The shogun himself pays 10-50x. Based on the proposition that we can use a lot of little bets and certain creative methods to identify possibilities and build up to great outcomes. Equally down with the prop-betting action, tom dwan mentioned that he'd be willing take a bite.
You can see every aspect of his stripping on three separate websites: rodney st. Ive cut back on fitness as my caloric intake is so low. Each evening i will email you the exact bet and stake i am placing for the following day, i will even tell you which bookies i am using for this bet. This church dates to 1914 and was designed in the nordic romantic style by sigfrid ericson who also conceived gothenburg's museum of art. Lucky me, i got a sweet view of boston on departure. Riding a camel through the casino el mamounia in marrakesh, morrocco. Also got to see hundreds and hundreds ofexamples of companies that just did very mediocre, didnt do wellat all. Crazy little bets is a system which got launched in the market with astounding claims, crazy little bets is now the buzzword in the industry. The bigger the barrier to entry, the higher the price of the first bet.
You'll see it when you see it. When did we start viewing one of these pictures as "wrong". I miss the days when men held open doors, protected a women's purity, and pursued the heart of a woman. Just a one-time investment of a seemingly big amount creates a win-win situation for both of us by using crazy little bets. Change was originally to be april 29, but it was moved up two weeks. Sweet jesus, today i will choose to watch and wait for you to open the window of freedom.
The expanding wild substitutes for all symbols except the scatters. We blame men for the problems of the world and put our sex on a pedestal all for the sake of "being equal". If you're stopping yourself from being social caused by lack of confidence and even feeling embarrassed with ourselves then just choose crazy little bets and pay attention to how your life changes within few days. Beth moore said "we are god's present armor-bearers. Thanks to phil kirkman and his morning reports, i started to make money on a regular basis and now my income is more stable than i've ever thought it could be. Our team have donned their armor to take a closer look at the shogun's secret crazy chicken shooter slots game. Show you how to bet no more. If you select the top golden nights bonus side bet, you can access the super jewel jackpot worth 50,000. That is, you can to transunion for a score, but there's no transunion monitoring.
Right now, developers can try out a new windows terminal command-line app. Crazy little bets is often a full package of happiness behind a very successful life. "ousmane is an incredible player, he's really talented. But be warned it's just reports — no monitoring, no scores, and you're limited to one report per bureau per year. Staking appears to be a varied affair with ashley cannon saying that you can bet just £1-£3 per day, however the actual points staked will depend on the type of bet that you are looking at. Tom 'durrrr' dwan took a bet against the poker elite that he would be able to bag himself a bracelet at the 2010 wsop.
Thinking in a second language leads to better decisions. Because most people will want or need to reinvent themselves several times throughout their life, this can be a valuable resource, because you'll have a variety of people to turn to for advice, connections, and information. I remember being blown away by the off-the-cuff speech-making ability of sidney harman, founder of the electronics firm harman international. Our shogun's secret crazy chicken shooter slots release team enjoyed the free spins. Im just driving the train. The truth, however, is that tom izzo is going up a guy that couldn't get north texas going. Many people have created wealth from betting. Is it the artist's gut that decides before artistic intellect decides. She sighed and sat up.
Despite being low risk and high reward it does get frustrating then you place the wrong bet and just miss out every day for a week. On july 5, 1957, the shoppers special was. We strongly recommend crazy little bets to you if you are one among the millions who feel fed up with throwing away their hard-earned money to scammers. It is the simplest betting formula which offers you betting options with the lowest risks. The subject of affordable losses highlights a key issue with the little bets approach, it inevitably involves failure. Because this is sold though clickbank there is also vat to pay on all of these prices however there is a 60 day money back guarantee in place should you be unhappy with crazy little bets. I didn't even let it raise my blood pressure. How are we going to create theknowledge we dont have.
"this is a song i wrote," she declared, just before we cut to black. Falling ridership and as a depression economy move. You have confidence to yourself in betting once you have this program. And the bets just get crazier and crazier. He loved the fact that humans with inner self control could do most anything. The system gives you all the information you need to know about betting.
This makes the program safe and gives you the opportunity to make your betting simple. I was surprised that even in the middle of the night you could get a reply to your messages. The last gothic monument in porto is this church completed in 1425. Before off-track betting was legalized, many of these kinds of weird wagers were made within in the confines of gentlemen's clubs (not those kinds of gentlemen's clubs).
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Avondale Shipyards Division of New Orleans, under subcontract from Ingalls Shipbuilding Division, will perform the major work that is required in the drydocking of the battleship Wisconsin (BB 64), including the pumping out, gas freezing, repairing, and all of the coating of the ship's fuel and water tanks, replacement of propellers, inspection and repair of the shafts and rudders, and the inspection and repair of the sea chests and sea valves.
In addition, the entire exterior of the ship's hull will be recoated.
The Wisconsin will be docked in Avondale's 81,000-ton floating drydock using the techniques that were previously used to dock the battleship Iowa, which safeguard the vessel from fire and other dangers involved in this type of work.
At its peak, the work will provide employment for about 1,150 workers.
When Avondale completes its work at the end of this year, the Wisconsin will then be towed to Ingalls in Pascagoula, Miss., for the remainder of its reactivation work.
Avondale's reactivation work adds to its backlog of six T-AO 187 Class Fleet Oilers and five LSD-41 Class Landing Ship Docks.
For free literature on Avondale's facilities and capabilities, Circle 1 4 8 on Reader Service Card
.8-million contract option with Ingalls Shipbuilding division of Litton in Pascagoula, Miss., for the reactivation and modernization of the battleship Wisconsin (BB-64). The option is part of a contract awarded to the shipyard earlier, and is in addition to the $1 million received at that time to beginning th
, he was assistant product manager-hydraulic products. Mr. Nordquist holds a mechanical e n g i n e e r i n g degree from the University of Wisconsin- Madison, and an MBA degree in business administration from the University of Wisconsin-Oshkosh
provides detailed specifications on the broad line of stainless-steel and specialty alloys available for centrifugally cast parts from Wisconsin Centrifugal, Waukesha, Wis., a leading U.S. producer of centrifugal castings for original equipment manufacturers. The brochure contains data
240-ton tug after it sank in the Port of Green Bay, Wis. The marine construction and salvage company that was called to raise the tug consulted with Wisconsin Lifting Specialists Inc., a Slingmax dealer in Milwaukee, Wis., who recommended using Kevlar® Twin- Path slings over traditional wire rope slings
result of the combining of three companies who were engaged in similar activities. Over time, Lidgerwood purchased the Superior Iron Works of Superior, Wisconsin and Mundy Hoisting of Newark, NJ. Now all manufacturing and administrative activities of Superior-Lidgerwood-Mundy are accomplished at Superior,
a diverse base of high quality suppliers for the underwater industry. The Company: 2G Engineering is a privately owned company located in Southern Wisconsin. It incorporated in 2005 by founders Hal and Taylor Glenn. It has been expanding its engineering expertise throughout the years by tackling diverse
, U.S. Atlantic Fleet; Vice Adm. William H. Rowden, USN, Commander, Naval Sea Systems Command; Under Secretary of the Navy, H. Lawrence Garret III; Wisconsin Congressman Les Aspin, Chairman of the House Armed Services Committee; Wisconsin Senator Robert Kasten; Sturgeon Bay Supervisor of Shipbuilding
The Merrimac Ferry, which crosses the Wisconsin River between Sauk and Columbia counties, is Wisconsin's only free ferry. It shuttles WIS 113 traffic between Okee on the east bank and Merrimac on the west. In the 150 plus years that a ferry has operated at this location it has been propelled by muscle
Specification RR-C271D Type IV A, Grade A, Class 3. An Historic Selection Last year, UPC was selected to supply its fenders for WWII battleship USS Wisconsin's arrival at Norfolk, Va.-based Nauticus Pier. Known as the last of the great battleships, the 887 ft. (270.3 m) historic ship was welcomed to
States. In addition to the U.S.S. Iowa (BB-61), the class includes the U.S.S. New Jersey (BB- 62), the U.S.S. Missouri (BB-63), and the U.S.S. Wisconsin (BB-64). The ships were originally commissioned between 1943 and 1944, were in active status during both World War II and the Korean conflict
, Ely Street, Marinette, Wis. 54143. It is the latest of several management positions Mr. Derusha has held during his 20 years with the Wisconsin shipbuilder. Most recently, he served as vice president of engineering. The appointment is in keeping with recent expansion of production operations
resources for three of TOTE's the company's four terminals in Indi- Petters, were keynote speakers. "Un- four operating companies, including ana and Wisconsin. He has worked at the company for 24 years, climbing der Mike's leadership, HII's shipyards TOTE Services, TOTE Maritime Puer- build and maintain
partners for the project Steamship Company and Fincantieri Bay Shipbuild- include ABS, EMD Engines, Caterpillar, Lufkin (a GE ing of Sturgeon Bay, Wisconsin. The new River-Class, Company) and MacGregor. self-unloading bulk carrier will be the ? rst ship for U.S. There are many notable features of
materials to support manufac- turing throughout the Great Lakes region, also represents hundreds of good-paying jobs for U.S. Merchant Mari- ners and Wisconsin shipyard workers. Measuring 639 x 78 x 45 ft., the 28,000 dwt the vessel will be built in Sturgeon Bay, Wisconsin and is expected to be delivered
Mist in Niagara Falls, land and water across NY. In addition, Burger two facilities on the has built research ves- San Diego Bay and a sels for the Wisconsin third facility in Cabo. DNR and U.S. Geolog- Featuring one of the Marine Group Boat Works Burger Boat Company ical Survey and passen- largest
of the Mist in Niagara Falls, NY. In addi- and many other ferries, yachts, research vessels, and pas- tion, Burger has built research vessels for the Wisconsin senger vessels. http://burgerboatcommercial.com The Case: CARVER PUMP For over 60 years, Carver Pump has proudly served com- mercial and military
academy's values and degree in business management from headquarters. A seasoned executive, mission set. Making it all possible, in the University of Wisconsin, and an Downey has extensive senior-level ex- part, were industry sponsors such as MBA from Marquette University. perience building and managing
– building our company's Company and Fincantieri Bay Shipbuilding of Sturgeon Bay, ? rst ship since 1981 – we knew it was critical to choose the Wisconsin. The new River-Class, self-unloading bulk carrier right partners. Fincantieri Bay Shipbuilding is the shipyard will be the ? rst ship for U.S
costs of food damages to im- Lake Pepin Backwater Complex proved recreational opportunities. Projects were qualita- Location: Upper Mississippi River, Wisconsin tively ranked as "Positive-Neutral-Negative." Summary: Dredged material from Lower Pool 4 will The top 10 projects emerged from the second sort
of project engineer and proj- ous 19 serving as rental sales manager Marad Issues RFP for Long ect management experience within a for southeastern Wisconsin. Awaited NSMV shipyard environment. Additionally, The Maritime Administration Four Students Receive EBDG hired Julie Schoenberg as the (MARAD)
ca- found, a 3,500 year old discovery in Turkey. bles for U.S. Navy submarines. The company regularly over- BIRNS connecters were in the University of Wisconsin's molds terminated connectors—made by BIRNS and by oth- Physical Sciences Laboratory for the IceCube Neutrino Proj- ers—to cable, per customer requests
corporate headquarters are located in Itasca, IL and their manufacturing, engineering and research and development operations are in Chippewa Falls, Wisconsin, and Janesville, Iowa. According to Fireboy-Xintex, nothing has changed – just the addition of still more industry contacts, opportu- nities and
all LCA members. The 2016 singular cost is worth a closer look: it increas- es to $263,000 in 2022 because of in-place rate increases. Conversely, in Wisconsin, the POTW for the City of Su- perior, on Lake Superior, has available capacity – but the plant is designed for 4 million gallons/day. Rayburn estimated
the one and a half times the size of a DDG monohull Freedom-variant at Fincantieri 51– it has 1/50th the radar cross section Marinette Marine in Wisconsin, while of an Arleigh Burke. Austal USA is building trimaran Inde- pendence variants at Mobile, Ala. Aegis Cruisers Concurrently the Navy is developing
showing their age and in dire need of repairs. Thanks to the recent approval of a USDOT FASTLANE grant along with State funding ac- quired through the Wisconsin Harbor Assistance Program across the country. In the ? rst call for FASTLANE grants, (HAP), ? nancial support for revitalization is now ? rmly
its global headquarters in Fond growing with share gains, particularly in River at nearly 80 mph anchor you are anchored in place despite du Lac, Wisconsin, Mercury Marine is the outboard segment." in a 39-ft. Cigarette boat the swirl of forces around the boat. a pure maritime power and supply play
received a PhD in Civil career at Teledyne RD Instruments and Environmental Engineering from (TRDI) located in San Diego. During the University of Wisconsin in 1986. this career he has worked as an He started his career in the U.S. assembler, technician, customer before coming back to France to join
House Total Lubmarine Another busy winter for Fincantieri Bay Laborde to distribute Joore Swartz Hubert Shipbuilding (FBS) in Sturgeon Bay, Wisconsin Bukh engines. low sulphur regulations by supplying it ed new manufacturing buildings and ad- Palau Ship Registry Opens Piraeus HQ with LNG, 0.5
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Manitowoc consultancy BMT Fleet are already understood to be endurance cutters, now up to 50 years old," the Service Marine Group and its two yards in Wisconsin, includ- working on project documents for a Canadian "arctic says. A Coast Guard management unit called OPC PRO ing the Marinette Marine that built
than a year at all? long and we ? nalized the purchase in I think the tide is turning, and the State the spring of 2016. It started out as a of Wisconsin is working hard to let the request to rent some warehouse space, younger generation know that it's okay and it turned into an acquisition of build- to
In Sturgeon Bay, Wisconsin ? nd 'The Best Kept Secret in Shipbuilding' By Greg Trauthwein In 2009, Italian shipbuilding giant Fincantieri S.p.A, purchased the assets of the Manitowoc Marine Group; which included Bay Shipbuilding Company. Located in Sturgeon Bay, Wis., Bay Shipbuilding was the "feather
USCG ing from MMI, Schneider moved back members both ashore and at sea, and Caleb King comes on board as man- ager SHEQ/Compliance Director. home to Wisconsin and went looking relief for USCG members and their King will be responsible for safety, for her ? rst job. Her resume was turned families during
the result of the combining of three companies who were 302 Grand Avenue engaged in similar activities. Over time, Lidgerwood pur- Superior, Wisconsin 54880 chased the Superior Iron Works of Superior, Wisconsin Telephone: (715) 394-4444 and Mundy Hoisting of Newark, NJ. Now all manufactur- E-mail:
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On August 8th CFA Society Chicago hosted an ESG event focusing on alternative energy. This event was structured with a featured keynote speaker, followed by a moderated Q&A with a panel of four alternative energy asset investors.
The keynote speaker was journalist Amy Harder of Axios. Based out of Washington, D.C., Harder covers national energy and climate change issues in her regular column, "Harder Line," as well as reporting on trends and scoops. She is adept at discussing complex energy and climate issues in ways that everyone can understand. She is the inaugural journalism fellow for the University of Chicago's Energy Policy Institute. Before joining Axios, she covered energy and climate change at the Wall Street Journal, and before that, the National Journal.
The panel consisted of moderator Martha Goodell and panelists Susan Nickey, Clive Christison, and Ammad Faisal, CFA.
- Goodell is a co-founder and managing partner at Enigami Partners, LLC in Chicago, which supports institutional clients with all aspects of the investment process supporting private structured finance. Enigami's clients are investing in energy technologies, projects and infrastructure.
- Nickey is a managing director at Hannon Armstrong, a leading capital provider for sustainable infrastructure markets that address climate change. She was previously the founder and CEO of Threshold Power.
- Christison is the senior vice president of pipelines, supply, optimization and specialties for Fuels North America; he is responsible for BP's commercial, supply and optimization activities in the Americas. He is based in Chicago.
- Faisal is managing director and co-head of the Chicago office at Marathon Capital. His firm as an investment bank in the energy and power sectors, and he focuses on mergers and acquisitions, debt, equity and tax equity capital raise transactions.
Harder led off the event with some remarks about the state of the energy industry, energy infrastructure and how it relates to regulation on national and international levels. She opened with a note about how the phrase "alternative energy," as a reference to energy sources that aren't fossil fuels, marginalizes what are already very viable sources of energy.
In 1987, fossil fuels made up of 81% of energy sources. In 2017, it was still 81%. There was relatively little fluctuation over that 30-year span. In addition, Harder made the point that hydroelectric technology is 150 years old and is the primary clean energy source in the world currently. However, hydro is in decline, while wind and solar are in ascendency. Wind has recently passed hydro as the main source of clean energy in the United States.
Harder explained that it is unlikely that all our power will come from wind or solar by 2050 – or ever. The main reason is the lack of suitable storage technology. Battery technology is not up to the task of storing energy in the amounts that can accommodate consistent and steady power supplies at this point. Wind and solar costs have dropped considerably, but that drop has been matched by a drop in prices for wind and solar power. This has made investment returns on wind and solar developments worse, which has slowed down investment in clean energy projects.
Additionally, batteries themselves are more difficult to develop because investing in battery technology is tricky. The availability and costs of the metals involved in producing the batteries could make them cost prohibitive. As a result, natural gas will likely be a part of our energy source mix for the foreseeable future.
In Australia, which has a highly developed clean energy infrastructure, one answer to the storage issue is the use of pumped hydroelectricity. Water is pumped to create electricity on demand, which effectively stores the electricity. There are some issues with pumped hydro, though, including having to dam any river used to create the electricity.
Harder then began to discuss carbon capture. Carbon capture is the process of retrieving greenhouse gases from the atmosphere. This is a technology that is starting to gain real traction in the investment community and has great promise to help slow down global warming.
In response to some of the challenges we face, many large-scale investors, such as the Government Pension Fund of Norway (their sovereign wealth fund) has divested its investments in companies that specialize in oil exploration and production. The belief among many in the energy community is that over time, the oil exploration industry will consolidate like a game of musical chairs. There will be fewer and fewer "chairs" over time as governments begin to enforce higher levels of regulation. This move by the Norway sovereign wealth fund is indicative that this process may have begun. Europe has been the leader in this process so far.
As for the United States, President Trump's policies are not as opposed to clean energy as his rhetoric has been. While he has publicly shown strong support for conventional energy sources, there have not been as many policy changes as his rhetoric might indicate. Still, the Green New Deal is extremely unlikely without a Democrat president, Democrat majority Senate and Democrat majority House, and on top of that, some cooperation from Republicans in Congress. Climate change is starting to be more of a political liability for Republicans, according to Harder.
A question from an audience member was for Harder's opinion on carbon credits as an effective policy. Her answer was that there are really three options for ways to manage carbon emissions – innovation to new technologies, carbon tax, or a cap and trade regime. Cap and trade is politically unpopular because of the "energy tax" label slapped on it during previous debates, but would probably be very effective. Renewable energy mandates would probably not be as useful for businesses, but they are politically popular.
Harder signed off, and the panel was introduced.
Goodell began by asking each panelist about what specifically they do in the energy field. Nickey's firm, Hannon Armstrong, invests in different types of projects that either make the energy grid more efficient, such has highly efficient light bulbs, or in projects that actually generate energy. Christison works for BP and actually manages energy projects for BP, including identifying potential projects. Faisal is in the business of finding capital for clean energy projects with Marathon Capital.
Goodell asked Christison how BP and other corporations make decisions about investing in clean energy projects. Christison said it depends on the technology. BP, for example, has a group that evaluates projects that deal in emerging technologies. Most corporations have investment return hurdle rates that must be met; conventional energy projects are certainly subject to these hurdles, but these emerging technology projects don't usually pass those internal hurdles. This requires a different type of analysis to make an investment decision.
Goodell followed that question with a question about if different renewable technologies might cannibalize each other, making those investment decisions more difficult. Christison replied that it was not as concerning because the focus for BP is on increasing its exposure to technologies and emphasizing a less conventional energy mix. In the transport field, it is likely that the energy mix will still be at 80% conventional by the year 2040, but renewables will increase in other sectors. The number of vehicles in the world is likely to increase rapidly between now and 2040, so there are some time frame challenges that make it a better solution to build out the various technologies rather than trying to pick a winner. All four panelists affirmed that wind and solar technologies are the unquestioned leaders in the clean energy space.
Goodell asked Nickey about the green bond market and its place in her firm's investment strategy. Nickey replied that the market for green bonds is still very small, at roughly $100M in annual issues versus the global bond market of around $12T. It's a part of their overall investment purview and a space where there is room to grow.
Goodell asked about the global leaders in renewable technologies. Christison answered that China was the clear leader in electric vehicles. The US is progressive on renewable gas, which is supported by credits. Europe is strongest in social and political awareness of climate change and backs it up with policy. Spain, for example, last year wanted 100% of its electricity from renewable sources but had to default to gas power during times where the wind wasn't blowing sufficiently. Southeast Asia is the leader in the development of biofuels. Christison gave the example that algae-based biodiesel is an emphasis in Southeast Asia.
Goodell asked Faisal about the level of deal flow now as opposed to previous years. Faisal answered that deal flow is quite a bit stronger, especially in the wind and solar spaces. He also mentioned that European companies have been quick to step into deals outside of Europe, taking advantage of slower movement from other global players. An example was the growing area of leases on existing offshore windfarms, which are quickly being acquired by European companies and investors.


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Weather :- variable light winds
Early in the morning a Greenshank spent some time at the north end and then flew off high to the south west, whilst 7 wandering Canada Geese also reminded us that autumn was now here. Very little sign of passage of small birds (15 Swallows, 3 House Martins ) until the surprise of seeing a Grasshopper Warbler in the trapping area in the afternoon, it had possibly been since the morning.
Tuesday, 3 September 2013
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Christmas Sparkle, San Francisco Style
By: Dana Rebmann | Date: December 24 2019
The holidays are merry and bright in San Francisco. City landmarks and neighborhoods are aglow with lights and decorations. Sparkling Christmas trees may outnumber loaves of sourdough bread and classic traditions mix and mingle with family fun. From ice skating to shopping and sipping holiday tea, the only thing missing is the snow. For an authentic San Francisco Christmas, don't miss these gems in the city.
Union Square
It's hard not to be in a festive mood at San Francisco's Union Square. Along with the Holiday Ice Rink there's the 83 foot Macy's Christmas tree complete with more than 33,000 twinkling energy-efficient LED lights and the Chanukah Festival of Lights. Day and night the square is bustling with crowds, many laden with shopping bags from nearby Macy's, Neiman Marcus, Nike and Tiffany & Co., just to name a few. (If you go: don't miss Tiffany's take on holiday wreaths made from those famous blue boxes hanging in their windows facing Union Square.)
Westin St. Francis Sugar Tree
The holiday glamour sparkles on at the Westin St. Francis, also located right on Union Square. This 110 year-old hotel knows how to do many things and the holidays are one of them. Revolving glass doors deliver you to the St. Francis Sugar Tree. The 12-foot-tall tree is decked out with more than 1,000 pieces of glistening candy made from pulled and blown sugar. It revolves so you can appreciate every sugary inch and there's even a moving train.
The Westin St. Francis pastry team began work on the tree in July, mixing in over 200 hours of work and 300 pounds of sugar to make it shine. The St. Francis Sugar Tree is surrounded by special presents where onlookers can donate to local charities.
Home Sweet Home
It wouldn't be the holidays without gingerbread and in San Francisco, they tend to take the shape of mansions as opposed to houses. At the Palace Hotel the not so humble gingerbread abode includes 600 pounds of gingerbread, 250 pounds of royal icing and 300 pounds of assorted candy. History provides inspiration at Cavallo Point Lodge. A joint effort between the pastry and engineering department, their licorice laden house is actually one of Fort Baker's historic homes that's now part of the Lodge at the Golden Gate.
Tea Under the Tree, Sir Francis Drake
Kid or kid at heart, it's almost impossible not to eat dessert first when the colorful tiered tea plates arrive at your table. Tea Under the Tree at the Sir Francis Drake has all the makings of a family holiday tradition. Pretty tea sandwiches range from Nutella Banana and the classic PB & J, to Smoked Salmon with dill crème fraîche, Roast Beef with horseradish cream and Cucumber Radish with chive cream cheese. But it's the confections that bring about what I like to call sugar rush smiles. Petits-fours Presents, Whoopie Pies, Raspberry Linzer Bars and Rice Krispie Treats that shimmer with a gold luster. Mom and Dad can linger longer by the tree as the kids decorate a gingerbread person and make sometimes numerous trips to the Christmas candy bar.
Winter Walk SF
If all that sugar has lead to a little extra energy, head to Winter Walk SF to stretch your legs. For one month of the holiday season, two blocks of Stockton Street is closed to cars and blanketed in green. Thanks to plenty of artificial turf, a busy street becomes an open space to have a seat, a picnic, or just a second to walk a bit away from the crowds. When the sun sets Jack Frost tours San Francisco via a light show projected on the Macy's Men's Building.
SF SPCA Macy's Holiday Windows
Don't leave the Winter Walk without a visit to the Holiday Windows at Macy's, where some of the SPCA's most adorable, adoptable animals, wiggle their way into hearts and most importantly new homes. Since the tradition began nine years ago, the SF SPCA has raised over $400,000 and found loving homes for more than 2,300 animals.
Originally posted 2014-12-24 07:00:23.


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Department of Veterinary Clinic, Campus Botucatu, UNESP - Univ Estadual Paulista, Brazil
Received date: January 15, 2017; Accepted date: March 03, 2017; Published date: March 06, 2017
Citation: Tremori TM, Ribas LM, Massad MRR, Flórez LMM, de Almeida ECP, et al. (2017) Forensic Analysis of Three Pets: Victims of Carbamate Intoxication. J Forensic Res 8:370. doi:10.4172/2157-7145.1000370
Copyright: © 2017 Tremori TM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Cases of intoxication are common in the history of the veterinary medicine, mainly in dogs and cats. Appropriate recognition of the clinical signs and pathological findings could characterize cases of intoxication, however laboratorial methods in forensic toxicology is fundamental to establish a definitive diagnosis of the toxic agent. In the present work was made analysis of three cases of pet animals criminally intoxicated by carbamate. Necropsy helps to uncover causes mortis, were verified cardiac respiratory insufficiency and hypovolemic shock in all cases. Histopathology exam of liver, kidney and brain described the main lesions like congestion, degeneration and haemorrhage. Organs show signs of autolysis and putrefaction. Therefore, diagnostic techniques helps veterinarian to make reports for litigation in animal criminal intoxication.
Veterinary forensic medicine; Expertise; Toxicology; Forensic histopathology
Over the years, forensic veterinary medicine has experienced a significant increase of performance and effectiveness also because a raise of social sensitivity to animal cruelty. Non-accidental intoxication is frequent, mainly exogenous. However, animal crimes often remain unreported [1,2].
Criminal intoxication falls among prohibited conducts indicted by the Environmental Crimes Law, No 9.605/98. Specifically, Article 32 typifies as a crime to perform acts of abuse, to injure or mutilate wildlife, domestic or domesticated, native or exotic, providing imprisonment from three months to one year, and additionally, a respective fine [3,4].
According to previous studies, fatal intoxication occurs mainly due to pesticides, being 50.4% of cases caused by carbamates, 18.9% by anticoagulant rodenticides, 5.1% by organophosphate and 3.4% by non-anticoagulant rodenticides [5-7].
Non-violent deaths in animals should always be investigated to verify possible intoxication, because veterinarians routinely facing these cases [5,8-12].
On these terms, toxicology allows determining chemical action mechanisms in the body, clinical signs, post mortem characteristics (microscopic and macroscopic), necropsy findings, and toxic agent detection in order to get a reliable poisoning diagnosis. Evidence identification is extremely important to facilitate forensic investigation and necropsy report [1,13,14].
Toxicants are substances able to damage health, or even result in death. Depending on gravity of signs and symptoms, poisoning syndrome is classified as mild, moderate or severe. Some factors, alone or in combination, contribute to its manifestations such as dose quantity, individual strength, exposure time, and the route of administration [15,16].
If the animal dies, forensic necropsy and histopathologycal analysis, associated with a drug testing, are needed to reach an accurate diagnosis. Thus, the confirmation of suspected cases increases [7,9,13,17,18].
Finally, necropsy report plays a key role by clarifying facts, and defining death cause. Likewise, forensic histopathology through a comprehensive tissue analysis is quite helpful for interpretation [10,19,20].
Three cases of pet intoxication were selected from records of the archives at Veterinary Pathology Service-FMVZ from July 2014 to January 2015. Although more cases have been found furthermore this study was requested only that were comply with all requirements: forensic necropsy reports, microscopy analysis, judicial requests, and toxicological examination.
The reports were documented by photographs (JPEG Image DSCH9) before undergoing necropsy. The autopsy technique was the modified Ghon, which consists of the opening of the skull and thoracoabdominal cavity to extract organs in anatomical and functionally related blocks, totaling four. Picked organs were removed from each block and examined in detail. Some of them were photographed (JPEG Image DSC-H9) for registry purposes [20].
Concurrently to necropsy, samples were collected for physical and chemical analysis, and histopathologycal conventional exam, regardless time of death. For the physical-chemical examination, duplicate samples of liver and kidney (30 gm) were harvested from each animal, then identified, packed and, sometimes, refrigerated.
One of the duplicate specimens was sent to the toxicology laboratory with the request form and death certificate, which included possible poisoning agents, in order to identify and quantify their chemical compounds. The other duplicate was kept in custody until obtaining toxicological official results, and later discarded, according biosecurity protocols.
For histological analysis, samples of kidney, liver and brain were placed into individual vials containing 10% buffered formalin, at minimum proportion of five times specimen size. It remained so until processing, according to conventional methods. Thickness of cuts ranged from 4.0 to 5.0. Staining was made by using Hematoxylin and Eosin (H&E).
For morphological expression of lesions in brain, kidney and liver, from both macroscopic and microscopic perspectives, the criteria contained in referential textbooks prevailed. In this case, characterizations were focused on lesions caused by the action of toxic compounds, especially on those causing degeneration and other types of non-reversible damage to cells or tissues comprising such organs [19,21,22].
The first animal was a four-year male dog, non-defined breed (NDB), positive for carbamate by a qualitative drug testing. Macroscopic study showed a whitish and frothy fluid at the final third of the trachea, extending to larger bronchi. Lung displayed extensive reddish and crackling areas. Stomach had a moderate foamy yellowish liquid along with a substance of granular aspect and blackened shade. A discrete hepatomegaly with an intense red color was found at liver. Pancreas had a softened consistency. Sulfhemoglobin stains were on the outer surface of spleen, which characterize a decomposition process. Moderate blood vessels with a dark red color were also detected in brain and skeletal muscles of the skull.
On microscopic examination, liver revealed a marked microvacuolation and degenerate hepatocytes near lobular vein center with the presence of "ghost" cells. A significant trabecular congestion was verified by the presence of large quantities of erythrocytes in blood vessels. Kidneys had congestion and microcalcifications.
The cortical and medullary vessels were bleeding with an intense and diffuse blockage. Tubular cells showed a severe vacuolation and a moderate quantity of hyaline material in the glomerular space. In some renal regions, degenerate cells detached from the basement membrane and massive pyknotic nuclei were present, all related to autolysis of parenchyma.
Brain evaluation unveiled a moderate disseminated intravascular coagulation (DIC), absence of inflammation, rare satellite cells nearby to neurons. In the gray matter, a region with bone tissue, head trauma indications and bruises appeared. This coincides with lesions verified by microscopy of erythema on temporal muscles covering skullcap. Besides, moderate bleeding was located in meninges and cerebral cortex (Figure 1).
A histopathologycal examination of lungs disclosed edema, pulmonary congestion and a severe CID, mainly due the presence of adhered red blood cells at the vessel wall, beyond a critical bleeding to the alveolar sacks by eritrocytes extravasation. The second case is related to an 8-month female feline, also NDB, positive for carbamate by a qualitative toxicology exam. At necropsy, an off-white and foamy liquid in the final third of the trachea was observed, extending to bronchial area with a deposition of blood with hypostasis at the left side of lung. Likewise, there was a moderate amount of unidentified food in the stomach, mixed with blackened granules. Encephalon presented evident lesions in blood vessels (Figure 2).
As for microscopic examination of liver, vacuoles close to portal space featured a pronounced fatty degeneration, and macroglandular steatosis. Brownish spots indicated biliary stasis (cholestasis), and a mild vascular congestion.
Kidneys demonstrated vascular congestion within medullary and profuse hemorrhage areas. Vacuoles at renal tubule cells of the cortex pointed to a minor fatty degeneration, and cell separation from basal membrane (Figure 3). In the brain, there was an incipient congestion and a moderately diffuse lung edema, followed by intra-alveolar bleeding.
The third considered sample was a 12-year female canine, SRD, also tested positive for carbamate. After forensic exam, a whitish-reddish frothy liquid was in the final third of the trachea, extending to the bronchi. Lungs displayed yellow irregular areas to multifocal coalescing.
Spleen had multiple nodules with whitish appearance, firm consistency, and irregular capsular surface, of approximately 1.5 cm diameter in average. Liver exhibited bulging lips, distended gallbladder, and filled of bile with lumpy appearance. Stomach lumen was filled by blackish liquid, greenish paste content in the bowel, presence of edema in the gastric and intestinal wall. Renal examination revealed capsular adherence in both kidneys, reddish subcapsular region, and expanded pelvis. Urinary bladder contained a whitish thick fluid.
Under microscope, liver tissue showed diffuse multifocal areas, large quantities of degenerate hepatocytes, mainly near the centrilobular region. Vascular congestion and diffuse areas with moderate bleeding also were watched. Kidneys presented a moderate infiltrate multifocal lymphoplasmacytic at the cortical region, extending to spinal area, vascular congestion with a slight hemorrhage. In fact, both organs suffered from acute tubular necrosis (ATN).
Brain was slightly congested with some red blood cells adhered to the capillary internal layer, and a light bleeding. A sharp pulmonary edema was characterized by eosinophilic amorphous material, prominent hemorrhage at interstitial region and vascular congestion.
Histological knowledge is essential for a proper understanding of the structure and functioning of cells, tissues and organs. After removing fragments for histopathological evaluation, samples must be preserved by fixation in order to prevent enzymatic tissue digestion, or autolysis, by the own cells. Commonly, forensic necropsies and specimens sent for examination are under decomposition. However, once received by the forensic staff, all material must be processed, and supported, in any case, by a technical report. If the sample quality affects the outcome, this information should be amended [23].
Liver acts as an interface between the digestive tract and blood. In this organ, nutrients are absorbed through the portal circulation, via the portal vein and hepatic artery, and later processed and stored.
In addition, the liver is the main organ performing the biotransformation. This chemical modification comprises a set of enzymatic reactions that alter activity and physical properties of various endogenous and exogenous compounds. Hepatic biotransformation develops two phases involving primarily the cytochrome P450 enzymes, mainly located in the microsomes of the endoplasmic reticulum of hepatocytes, especially those closer to the centrolobular vein (Rappaport zone III). The first phase accomplishes substance oxidation by cytochrome P450. Then, the resulting product is combined for excretion at the second phase. As a result, toxic or non-toxic metabolite formation occurs [24].
If, during the poisoning, the dose ingested by the animal is high, degeneration is possible to be seen in areas other than the region near the centrolobular vein. In acute poisoning, as the studied cases, zone I of the liver is the most affected by an intense deterioration of hepatic stem cells. This decomposition process is characterized by voids in the cytoplasm known as vacuoles.
Acute intoxication is not sufficient to trigger edematous responses. Consequently, inflammatory cells resulting from other processes will further exacerbate liver degeneration.
After death, liver autolysis begins immediately, due to the large amount of enzymes. Thus, the cadaveric phenomena change, rapidly and easily, organ structure, which can compromise histological evaluation.
The coagulative hepatocellular necrosis also occurs commonly in toxic injury, which may be focal or multifocal. In this case, the tissue architecture is normal. Hepatocytes with karyolytic, karyorrhexistic, and piknotic cores, and acidophilic cytoplasm are present [22].
Cholestasis (biliary steatosis) occurs by hepatocyte deterioration. In this way, a common finding is established in the hepatic histology of animals dying by poisoning, since chemical compounds highly promote functional cell degradation in this organ. Likewise, the deposition of hemosiderin is usual because an increased destruction of red blood cells in the tissue. In the case of a fatal acute poisoning, observing hepatic fibrosis is unlikely. Nevertheless, if the animal survives, this lesion can be one of those irreversible since Ito cells, located between hepatocytes, gather vitamin A. When damaged, these cells lose fat granules and synthesize collagen, which is important to the fibrogenesis process.
Among post-mortem changes, liver coloration is very sensitive. It can be modified by the following facts: cadaveric lividity; print marks caused by pressure of ribs, leaving some areas with paler coloring; hemoglobin impregnation, becoming dark red; false melanotic in contact with the bowel, by eliminating hydrogen sulfide combined with the iron released by erythrocytes lysates causes greenish color; and gall soaking leaving yellowish spots [22].
Kidneys perform glomerular filtration, reabsorption, and tubular secretion. Chemicals typically induce renal injury for different reasons: glomerular epithelial cells can undergo a direct lesion; changes occurred in renal blood flow; and immunocomplex formation, especially by acute exposure, such as the case of toxic agents.
As noted, the tubular epithelium cells, primarily in the proximal tubules, are more susceptible to ischemia and nephrotoxins because its high metabolic activity and the amount of glomerular filtrate reabsorbed during urine formation process [25].
In toxic damages, hyperemia is manifested with blood stasis. Macroscopically, cuts reveal increased blood flowing on the surface, actually redder. Microscopically, all blood vessels, especially capillaries, are congested, matching the literature [26].
Acute tubular necrosis (ATN) is the leading cause of kidney failure. Generally, ATN results from degenerative nephrotoxic lesions to kidney epithelial tubules. The microscopic appearance of kidney varies depending on damage grade, exposure time to the toxic agent, and the interval between lesion and death. Histological examination disclosed an extensive necrosis of proximal tubules with, or without, basal membrane preservation. Lesions with greater intensity were in the cortex, and into a lesser extent, in the renal marrow [27,28].
An important aspect is to realize the existence of deadly diseases of neurological origin with, or without, macroscopic or microscopic changes on nervous tissue, such as intoxication by strychnine, carbamate, and organophosphate. As a result, pathologist must proceed through toxicology techniques [29].
Finally, correlation among findings of illegal poisoning cases here described matches what literature points out. Therefore, strengthening forensic veterinary pathology becomes a very important matter for the suitable completion of necropsy report [30].
Based on macroscopic and microscopic interpretation of anatomopathological findings related to illegal poisoning of dogs and cats, it can be concluded that the use of histopathological and toxicology techniques were complementary. The analysis of cell and tissue alterations in some organs, along with toxicant agent tests, facilitated the understanding of criminal intoxication in selected samples. Thus, applying proper techniques of veterinary legal medicine can contribute to produce material evidence for the benefit of judicial processes involving animals.
CAPES (Coordination and Improvement of Higher Education Personnel Development) - Brazil.
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