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Volodymyr G Yareshko, Anton V Yevseiev, Yurii A Mikheiev*
Department of Surgery and Minimally Invasive Technologies, Zaporizhia Medical Academy, Ukraine
*Corresponding author: Yurii A Mikheiev, PhD, Assistant Professor, Department of Surgery and Minimally Invasive Technologies, SI Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine, Vintera boulevard 20, Zaporizhia, 69096, Ukraine
Submission: February 20, 2018; Published: March 21, 2018
Volume1 Issue3
Background: The duct cells make up to 30% of the human pancreas. One of the first signs of chronic pancreatitis is the abnormal increase in the number of duct brunches. The pancreatic ductal changes, periductal, inter- and intralobular fibrosis etc. are not the causes of chronic pancreatitis, but its consequences. The aim of the present study was to determine morphological and immunohistochemical features of the pancreatic duct system in patients with chronic pancreatitis, who underwent surgery for chronic pancreatitis.
Materials and methods: An immunohistochemical study of the surgical material of 40 patients with complicated chronic pancreatitis was carried out using antibodies to α-SMA, desmin, fibronectin and type I collagen.
Results: A characteristic morphological picture of the chronic pancreatitis in development is a combination of fibrosis with deformation of the duct system due to periductal fibrosis with the expansion of interlobular fibrosis, thickening of intralobular connective tissue strands, as well as considerable crimp and widening of the ducts with retention cysts. Significant structural reorganization of the pancreatic duct system in patients with chronic pancreatitis was observed in 87.5% of cases, in 17.5% of cases the picture was supplemented by phenomena of acinar-ductal metaplasia with the transformation of acinar cells into ductal cells and the formation of small ductal-like structures, the so-called "tubular complexes". In 7.5% of the cases in the main pancreatic duct, foci of atrophy of the epithelium were identified, which alternated with foci of papillary intraepithelial epithelial hyperplasia (PanIN). The development of pancreatic fibrosis in chronic pancreatitis is facilitated by the accumulation of α-SMA+ activated pancreatic stellate cells synthesizing an excess of components of the extra-cellular matrix, in particular type I collagen. The mean area of type I collagen and the intensity of its expression were significantly lower with reduced α-SMA expression (p <0.05), and significantly higher in cases of pronounced fibronectin expression (p <0.05).
Conclusion: The study of structural changes of the pancreatic duct system in patients with chronic pancreatitis using immunohistochemistry is one of the ways to understanding of pathogenesis and progressing of chronic pancreatitis.
Keywords: Chronic pancreatitis; Duct metaplasia; α-SMA; Desmin; Fibronectin; Type I collagen
Aim The aim of the study was to determine the morphological and immunohistochemical features of the ductal system of the pancreas of patients who had undergone resection and draining operation due to complications of chronic pancreatitis.
Chronic pancreatitis is a disease of the pancreas in which recurrent inflammatory episodes result in replacement of pancreatic parenchyma by fibrous connective tissue. Chronic pancreatitis is characterized by specific changes in the structure and function of the pancreas, including atrophy of functional tissue, fibrosis and duct degeneration [1-3], a decrease in the number of islets of Langerhans [1]. Despite the large number of possible etiological factors, the main pathophysiological mechanisms of the development of chronic pancreatitis have much in common. Thus, with the preservation of secretory activity in conditions of obstruction of the ducts, their compensatory expansion and pancreatic secret infiltrates the surrounding tissue with the formation of edema of the pancreas, followed by intrapancreatic activation of digestive enzymes, in particular trypsinogen, which initiates proteolytic necrobiosis of pancreocytes [4]. In the future, this leads to the formation of "protein caps" pancreatic ducts, due to increased secretion of pancreatic proteins, which are the centers of calcification and lead to the formation of concernments in the ductal pancreatic system [5]. As a result, the epithelium of the ducts is affected, which forms molds and clogs of the ducts, thereby causing inflammatory changes and loss of functioning pancreatic parenchyma due to fibrosis [4,6,7].
The duct cells make up to 30% of the mass of the human pancreas, compared to 1-2% of endocrine cells [8]. One of the first signs of HP is the abnormal increase in the number of brunch ducts. It has also been shown that in patients with HP in the ducts, the number of cells containing insulin increases, as well as cells that contain other endocrine and exocrine markers [9]. When modeling pancreatitis in a rat experiment was made, it was confirmed that cells of epithelial origin are involved in the regulation of the extracellular matrix (ECM) of the pancreas [10].
From the biochemical point of view, ECM consists of four main classes of macromolecules - collagens, proteoglycans, structural glycoproteins and elastin [11,12]. Structural strength and functional unity of ECM proteins play an important role in maintaining the organ-specific function of the pancreas [12,13]. Significant progress in understanding the development of fibrosis in chronic pancreatitis is associated with the identification of pancreatic stellate cells (PaSCs), which are capable of producing ECM, including excess [14].
For the first time lipid-containing cells were found in the human pancreas, rats and mice in 1982. Although the potential role of these cells in fibrogenesis was already discussed, another 8 years passed before scientists could isolate and characterize them [15]. PaSCs are located in the intralobular and intraacinar space of the human pancreas and have the characteristics of myofibroblasts: an examination of the a-isoform of smooth muscle actin, the synthesis of collagen and fibronectin [16]. Also, PaSCs express intermediate filaments that are characteristic of myocytes - for example, desmin.
There are three basic mechanisms by which activation of PaSCs in chronic pancreatitis may occur: mechanical stress, production of cytokines and changes in ECM [14]. The content of fat droplets is inversely proportional to the expression of SMA and the synthesis of ECM. The transition from the latent "lipid-containing" form to "myofibroblastoid" with high proliferative properties is associated with the loss of drops of retinol, the development of endoplasmic reticulum and an increase in the synthesis of ECM proteins. Unlike the latent form, active or "synthesizing" is characterized by the synthesis of large volumes of collagen of the first type and fibronectin [11,17].
The activation of the PaSCs follows their proliferation and migration. In cell culture, activated PaSCs rapidly proliferate and migrate under the control of chemotaxis toward the damaged tissue [18]. In addition to active migration to the injured sector, their absence in normal tissue is controlled by apoptosis. With the activation of PaSCs, a number of morphological changes occur, including changes to the myofibroblast-like phenotype, which synthesizes and secrets a large amount of type I collagen and fibronectin [19]. The shift in self-regulation of the PaSCs leads to an excessive accumulation of ECM and/or a reduced rate of its destruction, involving healthy functional-significant structures of the prostate in the process of fibrosis [14,20].
Comprehensive histopathological and immunohistochemical study was performed in the histological and immunohistochemical laboratory of the University Hospital of Zaporozhye State Medical University based on postoperative material of 40 patients aged 28 to 74 years suffering from chronic pancreatitis, who were operated at the clinic of the department of surgery and minimally invasive technologies SI "Zaporozhye Medical Academy postgraduate education of the Ministry of Health of Ukraine".
For performing histological biopsies of pancreas were fixed in 10.0% neutral formalin, dehydrated in alcohols of increasing concentration and embedded in paraffin. Histological sections 3-5 |im thick were stained with hematoxylin and eosin, according to the Van Gyzon and Mallory-Trichrome methods. Immunohistochemical study was performed according to the standard procedure [21,22] using monoclonal mouse antibodies Alpha Smooth Muscle Actin against a-isoform of smooth muscle actin (α-SMA) and desmin (Clone D33) against desmin (DAKO, USA), monoclonal rabbit antibodies Collagen I (Clone RAH C11) against type I collagen (Imtek, RF) and polyclonal rabbit antibodies Fibronectin against fibronectin (DAKO, USA). To do this, after dewaxing, high-temperature unmasking of antigens in Tris-EDTA buffer with pH 9 and blocking the activity of endogenous peroxidase in a 3% solution of hydrogen peroxide, incubation with primary antibodies was performed according to the recommendations of the manufacturer, followed by visualization of the product of immunohistochemical reaction using the EnVision detection system FLEX with diaminobenzidine (DAKO, USA).
Evaluation of immunohistochemical reaction with photodocumentation was performed using an Axioplan 2 microscope (Carl Zeiss, Germany) and a digital camera C5060WZ (Olympus, Japan). For photomorphometric study, 10 fields of vision were photographed in each case. To standardize the data obtained, the photos were taken under standardized conditions: an increase in the x200 microscope, a color (temperature) of 3200K, camera parameters F3.2 (aperture), 1/400 (shutter speed), ISO 100 (photosensitivity), manual white balance "one touch".
Quantitative determination of the levels of intensity and relative area of expression of the stromal markers was carried out using the ImageJ v.1.48 medical image processing software using the built-in Color Deconvolution plug-in and the H DAB color scheme (hematoxylin + DAB) to determine the area occupied by immunopositive structure in immunohistochemical preparations, and optical (densitometric) intensity of immunostaining according to the patented technique [23]. For the morphometric calculation of the quantitative content of the desired components, an automatically constructed histogram of the 8-bit half-tone image of the filtered DAB channel with software calculation of the optical density (Mean) and standard deviation (Std Dev) was used. For the subsequent morphometric measurement of the relative area in a halftone image, a standard threshold of sensitivity (the "Threshold" tool) was used to calculate the expression of α-SMA and collagen I, and Reniy Entropy to calculate expression of desmin and fibronectin. Due to this procedure, the digital image was segmented, which provides the separation of all image pixels into two types - black and white. Then the percentage of the number of pixels of the digital image of the immunopositive reaction (black) was calculated to the total number of pixels in the image.
One of the important features associated with the course of CP, is the order of development of characteristic microstructural changes in the pancreas. So, with the progression of fibrosis, the volume fraction of exocrine tissue decreases, the formation of fibrous tissue begins from the ducts, with subsequent attraction of perilobular space and penetration into the lobules [3]. In the pathohistological study of medicaments with a specific color of collagen (according to Van Gieson and Mallory-trichrome), fibrotic changes in all the patients with CP were characterized by a combination of pronounced perilobular fibrosis, which covered all lobules, widespread intralobular fibrosis (Figure 1A), as well as expressive periductal fibrosis near large, sharply defined, narrow and cystically dilated ducts. There was also a noticeable expansion of interlobular fibrous septum, a thickening of intralobular connective tissue strands directed deep into the lobules and connective tissue strands that surrounded the individual acini, as well as a significant crimp and widening of the ducts with retention cysts (Figure 1B).
Figure 1: Pancreas with signs of fibrosis. Color Mallory-trichrome, x400: A) Perilobulary fibrosis, connective tissue strands penetrate into the pancreatic lobes, breaking the characteristic acinar structure; B) Intralobulary strands of connective tissue depth direction slices, tightly cover the expanded ducts.
In most cases, the deformation of the flow system was related to the number of the most notable structural changes. So, in 87.5% of cases near the unevenly narrowed and cystic-altered interlobular ducts noticeable concentric fibrosis was observed, protein plugs and concrements were observed in the holes of the ducts. In 7.5% of the cases in the main pancreatic duct, foci of atrophy of the protocol epithelium were identified, which alternated with foci of papillary intraepithelial epithelial hyperplasia; pancreatic intraepithelial neoplasia Pan IN.
Figure 2: Pancreas with signs of fibrosis: A) Intralobular fibrosis, violation of the acinar structure, but with intact islets of Langerhans. Color Mallory-trichrome, uv. x200; B) On the site of the destroyed slices connective tissue penetrates into the islands. Color Mallory-trichrome, x400.
Among the acini, the islets of Langerhans were determined, both intact (Figure 2A) and tightly surrounded by fibrous tissue (Figure 2B). Recent research indicates that pancreatic islets begin to degrade only in the last stages of pancreatic fibrosis [23]. In our work, the involvement of the islets of Langerhans in the process of fibrosis was observed only in cases when the surrounding acini were almost completely replaced by a connective tissue.
The increase in the number of branch ducts during morphological examination was determined in the form of growth of ducts in two based types, which are characteristic for fibrosis of other parenchymal organs: continued, with the formation of a large number of parallel brunches of small and medium diameter (Figure 3A) and another, which differs by the deformation of the wall and the expansion of the section of the duct, with the formation of numerous branches of small diameter (Figure 3B).
Figure 3: Pancreas with signs of fibrosis: A) Increased mass of ducts due to the extended type of growth. Immunohistochemical reaction with antibodies to fibronectin, x200; B) Increase in the mass of the ducts due to the offgrowth type of growth. Immunohistochemical reaction with antibodies to fibronectin, x200; C) The tubular complex. Staining with hematoxylin and eosin, x400.
The parenchyma of the pancreas, thus, was a small, atrophic acinus, surrounded by dense fibrous couplings, with an increased number of gaping ducts of different diameters. Also, in 17.5% of cases, phenomena of acinar-ductal metaplasia (Figure 3B) were observed. In the centers of the so-called acinar-ductal metaplasia, the transformation of some acinar cells into ductal cells was determined with the formation of small ductuloid-like structures, called "Tubular complexes," which according to the literature are the primary focus of regeneration of acinar tissue [3,23].
Figure 4: Perineural fibrosis of the pancreas in chronic pancreatitis. A) Color Mallory-trichrome, x200; B) Immunohistochemical reaction with antibodies Rb a-Hu Fibronectin, visualization system DAKO EnVision FLEX. x200.
Figure 5: Expressed α-SMA-immunopositive staining of PaSCs and their processes, as well as the fibrillar component in the zone of pronounced pancreatic fibrosis. A) Color Mallory-trichrome, x200; B) Immunohistochemical reaction with antibodies Mo a-Hu Smooth Muscle Actin Alpha, visualization system DAKO EnVision FLEX. x200.
In the fibrosis zones, a few focal immune cell infiltrates were identified, more characteristic of the acute phase of the disease. In 45% of cases, the examined preparations showed the presence of perineural fibrosis (Figure 4), which potentially aggravates the pain reaction in chronic pancreatitis. Immunohistochemical and morphometric studies that were conducted have shown that in areas of severe fibrosis in chronic pancreatitis, a number of cellular and fibrillar markers is expressed. The results are shown in Table 1.
Table 1: Results of photocytometric morphometry of immunohistochemical preparations, M±σ.
In particular, in the fibrosis zones a large number of activated α-SMA + pancreatic stellate cells (PaSCs) is detected. The pattern of expression of this marker is characterized by marked α-SMA- immunopositive staining as a PSC and their processes, and partly - fibrillar component (Figure 5).
Primary statistical processing of morphometry data revealed a direct relationship between the expression of α-SMA and the area of type I collagen, but this relationship was not significant (r =+0.321, p<0,05). With the aim of further objectifying statistical studies, we isolated a group of cases characterized by low α-SMA expression (n = 9). A further study using medical statistics showed that the average area of type I collagen and the intensity of its expression in this group was significantly lower than in the rest of the biopsies (p<0,05).
In contrast to inactive PaSCs localized around the pancreatic lobes and in the outer layer ofthe main pancreatic duct wall, activated α-SMA-positive PaSCs play an important role in the development of fibrosis in chronic pancreatitis [1,3], secreting in addition to collagen a large number of other ECM components, among which an important role is played by fibronectin (extracellular matrix protein) and desmin (intermediate filament protein). In our study, fibronectin was visualized in the connective tissue, not affecting the acini, islets and epithelium of large ducts (Figure 6).
Figure 6: Expression of fibronectin in the connective tissue surrounding the panreatic acinus. Immunohistochemical reaction, visualization system DAKO Envision FLEX. x200.
In contrast, desmin was defined as in connective tissue, which was characterized by a lower intensity of immunostaining, and in acinar tissue and in the epithelial tissue of the pancreatic ducts (Figure 7). The pattern of its expression in zones of fibrosis in chronic pancreatitis was similar to that of α-SMA, but in 27,5% of cases the intensity of staining was below the threshold for determination by morphometric methods.
Figure 7: Expression of desmin in the connective (A), and in the acinar tissue of the pancreas (B). Immunohistochemical reaction, visualization system DAKO EnVision FLEX. x200.
Fibronectin, which is synthesized by virtually all cell types and which is presented in the pancreas in insoluble form as a fibrillar network on the cell surface and in the extracellular matrix [12], binds to aggregating procollagen fibrils and changes the kinetics of fibril formation in the pericellular matrix. We isolated a group of cases characterized by high expression of fibronectin (n=9). A further study using medical statistics showed that the average area of type I collagen and the intensity of its expression in this group was significantly higher than in the rest of the biopsies (p<0,05).
Thus, in the immunohistochemical study of the material of patients with chronic pancreatitis, it was found that a large number of activated PaSCs expressing α-SMA and desmin are concentrated in the zones of pancreatic fibrosis. Also in these zones, a significant accumulation of fibronectin was found, which is synthesized in excess by activated PaSCs. The pattern of immunohistochemical staining of type I collagen in the zones of severe pancreatic fibrosis is characterized by a low and moderate intensity with a moderate level of its expression.
Conducted immunohistochemical studies have shown that the presence of a significant number of α-SMA-positive PaSCs, as well as a significant amount of fibronectin indicate the activity of the fibrous process. The obtained data of morphological changes in pancreatic tissue in the study of surgical material in patients with complications of chronic pancreatitis are consistent with the latest data obtained in the study of fibrosing processes in the prostate and other parenchymatous organs [10,16,19]. The revealed perineural infiltration and perineural fibrosis in the parenchyma of the pancreas once again confirm the data about the complex mechanism of pain syndrome in this group of patients, which can not be explained only by central ductal pancreatic hypertension.
The process of activation of PaSCs is associated with structural disturbances of the duct system and destruction of the acini [3,23], which is consistent with the data of our study, where a pronounced pattern of involvement of the duct system in the process of fibrosis was observed in 87.5% of cases. In addition, the centers of pancreatic intraepithelial neoplasia Pan IN in patients with chronic pancreatitis, once again show that chronic pancreatitis is an optional precancerous condition. In this case, neoplasia begins with the epithelium, more often the main pancreatic duct, which can subsequently lead to the development of ductal pancreatic adenocarcinoma. This fact justifies the performance of virsuncectomy in the surgical treatment of chronic pancreatitis.
I. A characteristic morphological picture of the development of chronic pancreatitis is the deformation of the duct system against the background of fibrosis with considerable crimp and dilatation of the ducts due to periductal fibrosis with the expansion of interlobular fibrosis septum, thickening of intralobular connective tissue strands and retention cysts.
II. The pronounced structural rearrangement of the pancreatic duct system in patients with chronic pancreatitis was observed in 87.5% of cases, in 17.5% of cases the picture was supplemented by phenomena of acinar-ductal metaplasia with the transformation of acinar cells into ducts and the formation of small duktuloid-like structures, called "Tubular complexes". In 7.5% of the cases in the main pancreatic duct, foci of atrophy of the protocol epithelium were identified, which alternated with foci of papillary intraepithelial epithelial hyperplasia (PanIN).
III. The development of pancreatic fibrosis in chronic pancreatitis causes due to the accumulation of a- SMA + activated pancreatic stellate cells synthesizing excess of extra components of the cellular matrix, especially collagen I type. The mean area of type I collagen and the intensity of its expression were significantly lower with reduced α-SMA expression (p<0,05), and significantly higher in cases of pronounced fibronectin expression (p<0,05).
The authors declare that he has no competing interests.
© 2018 Volodymyr G Yareshko, et al. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and build upon your work non-commercially.


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Custom Financial Mortgage union bank construction loans construction and Lot Loans – America First Credit Union – Once construction is complete, you're qualified for a 0% origination fee on your long-term loan with America First; Up to 80% of acquisition cost; Flexibility on down payment requirements – see loan officer for details; And we'll make it happen with the following terms: Nine months, with extensions available. Low fees-Origination fee is only 1.50%Ocwen Mortgage Customer Log In – This site is supported on the following browsers: Internet Explorer 7.0 or higher ~ Click here to get it now Internet Explorer 8.0 or higher ~ Click here to get it now Internet Explorer 9.0 or higher ~ Click here to get it now Mozilla Firefox 3.0 or higher ~ Click here to get it now Google Chrome ~ Click here to get it nowfind construction loan broker barndominium construction Rafter J Construction – Commercial Metal Buildings: Victoria. – Rafter J Construction builds metal buildings of superior quality in Victoria, Texas and beyond.. Barndominium or warehouse; Shed, workshop or storage unit; From small workshops to complete offices and warehouses, we've completed a number of different projects throughout Texas. Trust that.Why Should I Own 'Little Brother' Blackstone? – Although BXMT is externally advised, I find the association with. investing in the specialized commercial mortgage sub-sector is the limited new supply constraints, completions are well below US.
203k faq's « Certified 203k Contractors – 1. What is an FHA 203k Loan? An FHA 203k loan is basically the same as a regular FHA [called a 203(b)], but with a twist. An FHA 203k loan permits home buyers to finance repair/improvement money into their mortgage to repair, improve or upgrade their home.
203K Contractor – Revolution Construction – fha 203k loans. revolution construction Inc. is specialized in 203k Rehab. The idea of buying a fixer-upper and turning it into your dream abode can seem so perfect – every nook and cranny just to your specifications! The reality, however, can be harsh.


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Mark BakerAOPA
With more than 10,000 hours of flying time over a 35-year period, Mark holds a Commercial certificate with single- and multiengine land and seaplane ratings, rotorcraft rating, and type ratings in Cessna Citation 500 and 525s. Mark currently serves as AOPA's President and CEO.


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programmer, maker, hacker, retrogamer | recovering GNU+Linux shill #RUNBSD | xmpp:firstname.lastname@example.com | https://kolucki.pl/
just look at this beaut
New typeface release: Comic Code. Ligature version is coming very soon. https://www.myfonts.com/fonts/tabular-type-foundry/comic-code/
I /really/ need to add http://n-gate.com to my rss reader because it's *so good*. This is the best description I've ever seen of the Microsoft acquisition of Github.
Unpopular opinion: By blocking Gab, you're helping Nazis. You're creating a safe space for them where they are among each other, not having to face contrary opinions and being able to radicalize themselves without intervention or it being noticed and acted upon by others.
I'm German and we had and have plenty of Nazis to deal with. Isolating them from society didn't help, it only made it worse and meant we didn't notice how much they radicalized themselves until they started killing politicians
Adblocking, old man yells at cloud
I grew up on dialup. 1200bps, max. I remember what it was like to get anything done at that speed, and now that it's no longer a thing I wouldn't inflict it upon anyone. That's why I try to keep my stuff as lightweight as possible, with as few deps as possible.
Treat others as you'd want to be treated, right?
A couple of years back I went to an HTML5 meetup and hung out with a bunch of web developers. I suck at web design (so much so that I didn't bother to try to write a new theme for my website, I used one that someone else made and tweaked it a little). One of the webdevs noticed that I use a couple of adblockers and yelled at me for taking money out of his mouth. That one cannot eat money, and that he gets paid a (much larger) salary (than I do) is beside the point.
So I put my laptop on the local network (Windbringer had been tethered to my mobile - OPSEC, ya' know) and asked him for the URL of the website he works on. He gave it to me. I opened it in a bare Firefox profile (no addons, no config tweaks, new right out of the box). His precious website loaded fully after just under three minutes.
Then, to make things fair, I rebooted Windbringer, got back on the local wireless, and opened it in my usual Firefox profile, with all the adblockers turned on. His website loaded in about five seconds.
"Your website loads so much tracking garbage up front that your page won't load in less than three minutes. I don't have time for that." And I left.
Unsurprisingly, I haven't been invited back, but my point stands - too much crap means your page won't load in a reasonable period of time.
> System/360 uses truncated addressing. That means that instructions do not contain complete addresses, but rather specify a base register and a positive offset from the addresses in the base registers. In the case of System/360 the base address is contained in one of 15 general registers.
/me screams internally at work
B612 is an open-source font developed by Airbus. It's the result of a research project to define and validate an "Aeronautical Font" to improve display of information on the cockpit screens, in particular in terms of legibility and comfort of reading. https://b612-font.com/
Still waiting the day of a RISC-V devboard that usable as a desktop under 700 USD. #riscv
programmer, maker, hacker, retrogamer | recovering GNU+Linux shill #RUNBSD | xmpp:email@example.com | https://kolucki.pl/
"I appreciate SDF but it's a general-purpose server and the name doesn't make it obvious that it's about art." - Eugen Rochko


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Holiday Cottages in East Barsham, Norfolk
Find a great selection of self catering holiday cottages in East Barsham, Norfolk.
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If you or someone you know has been diagnosed with cancer make sure they watch this video to help get informed on what cancer really is, how it forms and how to heal the root cause instead of just trying to get rid of the effects (the tumor) and find out later that tumors can keep coming back if you do not treat the cause- which is the CANCER STEM CELL!
Homeopathy offers some of the best hope and relief for Varicose in the form of Pulsatilla, Hamamelis, and biochemic medicine like Calcarea Fluorica. Our list of top homeopathy medicines for varicose veins offer the natural treatment which is safe and free of side effects Varicose Veins in brief Varicose veins are simply enlarged veins that… Continue reading Top Homeopathic Medicines list for Varicose Veins. Buy Online
In a survey of American cancer patients, baby boomers were more likely to support complementary and alternative treatments than people from an older generation.[20] White, female, college-educated patients who had been diagnosed more than a year ago were more likely than others to report a favorable impression of at least some complementary and alternative benefits.[20]
This flowering plant has traditionally been used as a liver tonic, useful for detoxification and improving liver function. Dandelion is known as a stimulant that is typically used for kidney and liver disorders. It is also traditionally used to reduce the side effects of prescription drugs, as well as to treat infections, gallbladder problems, water retention and swelling.15 Dandelion greens, which you can prepare simply by blanching them in boiling water for 20 seconds to help remove their bitter flavor (they can also be added to vegetable juice), contain many nutrients, including vitamin C, vitamin B6, thiamin, riboflavin, calcium, iron, potassium, and manganese. They are a particularly good source of vitamin A and may also have cancer-fighting properties.
New Hope Medical Center in Scottsdale uses alternative methods to treat immune deficient illnesses such as cancer. Dr. Fredda Branyon, Director, and Dr. Mario Galaburri, NMD, agree that a physician should never just treat the symptoms of the illness, but treat the individual as a whole. Dr. Ronald Peters, MD, MPH, has also joined the New Hope team, reinforcing New Hope Medical Center's commitment to offer its patients an aggressive, non-invasive approach to the treatment of cancer and other auto-immune diseases. Dr. Peters has 15 years of experience in integrative medicine and nutritional biochemistry, with special emphasis in the treatment and prevention of chronic disease. Phone (480) 556-0182, toll free: (888) 518-7788, or go to their website at http://www.newhopemedicalcenter.com/.
Vashisht Homoeopathic Pharmaceuticals founded by Rtn Dr.Vashisht has completed over 25 years in the field of manufacturing quality products and ensures 'a doctor's Quality' medicines. It was established in the year 1984 at Hyderabad, situated at I.E. Medchal Hyderabad, and adopted Good Manufacturing process (GMP). The quality assurance laboratory checks all raw material and finished product… Continue reading Vashisht Homeopathic Pharmaceuticals – Complete Catalog, Buy Online
Peppermint is a very well known herb today because of the amazing aroma it has when the leaves are bruised. It's used in so many different ways both culinary and medicinal it's hard to not include peppermint in our list of herbs. Peppermint originally came from England some time in the late seventeenth century and is actually a hybrid that comes from the water mint and spearmint. Peppermint was also extensively used in Ancient Egypt where they used it for indigestion, dried peppermint leaves have even been found inside of the pyramids that the Egyptians had built. During the eighteenth century peppermint became popular in Western Europe for treating things like nausea, morning sickness, and respiratory infections.
Chickweed is an annual herb that can be found all over the world in temperate as well as arctic regions. An interesting characteristic of the chickweed is that it sleeps, at night the leaves will fold up covering the young buds and shoots. Chickweed is also known for being quite a nutritious herb and is a good choice to include in your salads. The whole plant can be used both dried and fresh in herbal remedies. Let's have a look at the main medicinal uses now that this herb is best know for.
There are many foods that can be used as part of a cancer treatment program. Here are some links that you may find of interest. I think it is very important to remember that cancer is a systemic disease, which will require a systemic approach to cure. I had a friend who had terminal cancer, and he heard that grapefruit was good for treating cancer, so he told his wife to go and by two of them for him. Two grapefruits or a head of broccoli will not cure stage four cancer. Cancer is a serious disease and it requires a serious commitment to bringing about the cure. Such a commitment will require a total lifestyle transformation as you correct the conditions that led to the formation of the cancer.
In my opinion, when you find a certain therapy being criticized as being unproven quackery, then that is a pretty good sign that the alternative therapy is effective and safe. Big pharma would not waste their time preparing reports designed to warn people against using an alternative therapy unless that therapy is effective and has the potential for being a threat to their monopoly.
I can't say how underrated steam is when it comes to anything dealing with a cough, cold, or congestion. Not only does the steam quite literally loosen mucous and phlegm, almost immediately, but you can add numerous essential oils that will impart wonderful healing benefits. These benefits (anti-viral, anti-bacterial, anti-inflammatory etc.) do become airborne, so you inhale them while you breathe in the steam. For this particular blend I've included both tea tree oil and eucalyptus oil, which can help soothe and open your airways as well as help fight off bacteria or a virus.
This mushroom has a long history of use in Chinese herbalism. It is considered a great tonic for building physical strength and endurance. There is a substance in cordyceps which dilates the lung's airways, providing more oxygen to the blood. For this fact it is very popular with athletes. This healing mushroom is also used to treat asthma, cough and bronchitis. It possesses anti-inflammatory properties and has the ability to relax the bronchial walls. It's a great immune system booster as well.
** Information on the traditional uses and properties of herbs are provided on this site is for educational use only, and is not intended as medical advice. Every attempt has been made for accuracy, but none is guaranteed. Many traditional uses and properties of herbs have not been validated by the FDA. If you have any serious health concerns, you should always check with your health care practitioner before self-administering herbs. **
Acupuncture & Natural Medicine Clinic in Portland is run by Rick Marinelli, N.D., M.Ac.O.M. The clinic focuses on the successful treatment of chronic disease and pain, and can help with adjunctive cancer therapy, autoimmune and inflammatory disorders, diabetes, and degenerative disc disease. They use naturopathic medicine, acupuncture, Neural Therapy, Prolotherapy, integrated medicine, Orthopedic Medicine, herbal medicine, nutritional medicine, and detoxification. Website: http://www.natural-healthmedicine.com email@example.com. (503) 644-4446
Alternative cancer treatments have not undergone properly conducted, well-designed clinical trials. Among those that have been published, the methodology is often poor. A 2006 systematic review of 214 articles covering 198 clinical trials of alternative cancer treatments concluded that almost none conducted dose-ranging studies, which are necessary to ensure that the patients are being given a useful amount of the treatment.[6] These kinds of treatments appear and vanish frequently, and have throughout history.[7]
Other research conducted at the same institute studied possible regeneration of the islets of langerhans in rats that were made diabetic for the study and then given gymnema sylvestre leaf extracts. The diabetic rats were able to double the number of their islets and beta cell numbers. Researchers felt that the herbal therapy was able to bring blood sugar stability by repairing the pancreas and increasing insulin secretion.
As you might expect from an herb like basil it has a pretty profound effect on the digestive system and therefore works great for treating things like indigestion, bloating, and gas. When you're using basil to treat these problems I'd recommend taking around 2-4 grams per day taken orally. Basil can also be used to ease the effects of insect bites and stings, simply crush the leaves so the juices can be applied to the affected area. To help from getting bit or stung in the first place you can rub the juice on the skin in the same manner, basil works rather well as an insecticide so this should help repel the bugs.
Dr. Michael Uzik, ND. works with Arizona Naturopathic Physicians in Tucson AZ treats a wide range of conditions, including HIV, cancer, MS, chrones, etc. using nutritional IVs, mistletoe, ambrozile (oleander), copper reduction therapy for anti-angiogenesis, chelation, diet, herbs, heavy metal detox, etc. He is also an ND for Southern AZ AIDS Foundation. He only sees patients if they are under the care of an oncologist. 520-546-2321.


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We would like to wish you and your family an AWESOME 2020.
Ablazajade is focused on growing high-quality plants.
Look around our website and if you have any comments or questions, please feel free to contact us.
We hope to see you again! Check back later for new updates to our website. There's much more to come!


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Check out the great shots we got from the 2018 Ohio Conference for Payroll Professionals. The theme for this year was "Surfin Through Payroll". Click the link below to view them:
2018 – Surfin through Payroll
Thank you for your support!
The Ohio Conference for Payroll Professionals is an event organized in affiliation with the American Payroll Association.
Learn more about APA at www.americanpayroll.org.
Ohio Conference for Payroll Professionals - Copyright © 2010-2019P.O. Box 751, Dayton, Ohio 45475 | email@example.com by Next Level Technologies


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Midnapur: Four poachers arrested for poaching illegal leopard skin on Wednesday morning in West Bengal's Midnapur districts Khirpai area, police said.
The accused were Arvindyo Sau, Krisnakanto Sau, Asrabul and Samir Pal. To following a tip of secret, police was arrested this poachers from Choukan area. Police recovered illegal leopard skins from them.
Police also added that they gathered in this area for selling these skins into high price. Police lodged an investigation to probe the matter.


text: Steven Hill writes ... > A pallett arrived one day, marked for the attention of Gordon Bennett. At > 7 am, I was like "what the fuck is this?" at 9 Gordon walked in and asked > if something had arrived for him (he was our IBM CE) One disk pack. Maybe > a couple of gig, with platters about a foot in diameter. Heh. In the Gates CompSci building at Stanford they have one platter from their original hard disk drive. Solid steel, about an inch thick, and about 5 _feet_ in diameter. And it wasn't the only one in the "pack," either. As I remember the accompanying blurb, the drive took two hours to spin up and stabilize. How they delt with gyroscopic precession, I have no idea. -Shel


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England head coach Eddie Jones has Comprised Mako Vunipola and Jack Nowell Within his Team to face Argentina in the World Cup.
Vunipola (hamstring) and Nowell (foot ) have both recovered from long-term injuries to make the squad for Saturdays game in Tokyo, even though the set begins on the seat as England seem to make it three wins out of three in Pool C.
Jones has reverted to his starting XV that was most powerful after rotating his group to its 45-7 win over the USA.
Hes made one change to the side that beat against Tonga 35-3 in their opening game.
While Owen Farrell captains both by inside-centre, alongside Manu Tuilagi george Ford starts at fly-half.
Elliot Daly, Jonny May and Anthony Watson constitute the three, even while Ben Youngs will be set to be the most capped player for England.
Joe Marler, Jamie George and Kyle Sinckler are named in the row using Maro and Kruis Itoje as the lock pairing.
Tom Curry, Sam Underhill and Billy Vunipola will begin at the rear row.
Were in Tokyo for the first time and that the players are eager to be here and have really had a fantastic weeks prep up to now, explained Jones.
We all know Argentina are an excellent team and our players will be all set for the game.
Argentina is a completely different group from others we have played up to now in the pool stages and therefore so are constantly about the physical competition.
This week it is about getting our game right, our set bit in a great location and making sure defensively were organised and ready to find ways to score points from them.
England: 15 Elliot Daly, 14 Anthony Watson, 13 Manu Tuilagi, 12 Owen Farrell (c), 11 Jonny May, 10 George Ford, 9 Ben Youngs, 1 Joe Marler, 2 Jamie George, 3 Kyle Sinckler, 4 Maro Itoje, 5 George Kruis, 6 Tom Curry, 7 Sam Underhill, 8 Billy Vunipola.
Replacements: 16 Luke 17 Mako Vunipola, 18 Dan Cole, 19 Courtney Lawes, 20 Lewis Ludlam, 21 Willi Heinz, 22 Henry Slade, 23 Jack Nowell.
Read more here: http://karacapimapen.com/?p=8126


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you write, ... Wellington issued a proclamation requiring them either to join Soult's army..."
Why would Wellington issue a proclamation for anyone to join Soult's (the French) army? Sounds odd.
Certainly British Army officers (whom I am no big fan of) occasionally issued murderous orders in specific instances. Don't recall any such orders being the operating rule for a British army but if we go back in time enough and search wide enough there are probably some instances.
Sort of goes to prove my point when you have to go to the Fourth Anglo-Mysore War, not normally considered part of the Napoleonic wars, to find something like that from the Brits.
Most of your examples are the from the war in India. Does the British behavior in India really justify what N. did? Having never studied the wars in India, it's hard to comment much, but I suspect that they were all-around wars of no quarter given. Did the Indian Sultan conduct war according to the European rules of war? Probably not.
Wellington either knew or eventually learned that terrorizing the local population was, in the long term, not productive; at least that is the way he generally behaved in Spain during the Peninsular war. Wellington even refused to use the Spanish army in France because he didn't have the money to pay them and he knew that they would plunder the French. Wellington learned the value of restraint and paying for his armies local needs; something N. never did. It's also entirely possible that the way Wellington learned his lesson of paying for their local goods, and not terrorizing, was from seeing the vigorous reaction against the French army for all of what they did.
Also, "...I will act towards them as the French did towards the towns and villages in Spain and Portugal;.."
Sounds like a pretty darn effective threat doesn't it. Behave yourself or we'll bring down the same terror that your own army did on helpless villagers in Spain and Portugal!
Now if N. was in same position as Wellington's, he would not have reduced himself to mere threats, he would have issued a proclamation to hang examples and burn the villages at any sign of resistant: which was his standard operating procedure. N. never pussyfooted around like Wellington did.


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Most wore professional attire: dress pants and button-down shirts or dresses and shoes that clicked on the tile floors of Hardin Hall 141. They gave their final presentations, solutions to created environmental contaminant spills in pockets around the state, to a classroom of peers who had grown close over the spring semester.
The 10 graduate and undergraduate students in Natural Resources 451: Soil Water and Environmental Chemistry, separated into four groups, took their turns presenting their scenarios, their methods and their proposed solutions, and then fielding questions from their classmates and professor, Steve Comfort, soil and water chemist with the School of Natural Resources.
"All of the (environmental restoration courses) before this dealt with math and theory," said Rob Schroeder, senior environmental restoration science major at the time and now a graduate. "This was a real-world example." Real experience.
Comfort said the goal of the class is to teach students what happens to organic contaminants once they are released into the environment. "How are they absorbed? Degraded? Transported?," he asked, "What is the chance that these chemicals will get into and move with groundwater?"
The students learned about those processes during the semester, but then put that knowledge to work using a U.S. Geological Survey software called MODFLOW, or modular finite-difference flow model, for a final project. At the basic level, the program simulates and predicts groundwater conditions and groundwater to surface-water interaction, according to the USGS.
Using the program and models are important pieces to helping students synthesize what they learned over the course of the semester, Comfort said.
"As I listen to the students problem solve while working on their models, I hear them using the concepts and equations they learned earlier in the semester," he said. Only one of the 10 students had used the program before the class, but they all walked out of it able to list "MODFLOW experience" on their resumes.
"They've come a long way in fourth months," Comfort said with a smile.
For their projects, the students were required to pick a Nebraska location; determine the direction and speed of the groundwater movement; simulate a contaminant spill; predict how the contaminant plume would spread; analyze three to four possible treatment options; select one; and then use MODFLOW to simulate the groundwater cleanup.
Their PowerPoints were GIF-heavy, showing the various plume dispersals over time and how long it took for those chemicals to degrade to the Environmental Protection Agency's acceptable-level standard. The teams didn't hold back their creativity, with students providing elaborate back-stories for the contaminant spills, which ranged from benzene (one of the 20 mostly widely used chemicals in use, but one also used as an additive in gasoline) to atrazine (a crop herbicide) to toluene (used to tan leather, but also in aviation and automotive fuels).
The students included the human health ramifications of the contaminants, but also previous research conducted on the chemical, the details for how the chemical they chose interacts (or doesn't) with water and potential remediation options.
"The class seemed hard and intimidating, honestly, at the beginning," said Marisa Mika, junior environmental restoration science major, after the presentations wrapped up. But she realized how much she did know as the project unfolded.
Two of the graduate students gained the context they'd been missed from previous work or coursework.
"I was the one student who'd used MODFLOW," said Yaser Kishawi, a biosystems engineering graduate student, and a former environmental specialist with the Palestinian Water Authority. "I was using these values without fulling understanding why. … Now I know the connection between the parameters" set in MODFLOW and the outcomes of remediation.
"There is a lot of science to use to find ways to solve issues in a reasonable and scientific way," added Agustin Olivo, another biosystems engineering graduate student.
Based on what the students had to say, Comfort could consider the class goal achieved.
Shawna Richter-Ryerson, Natural Resources
Most wore professional attire: dress pants and button-down shirts or dresses and shoes that clicked on the tile floors of Hardin Hall 141. They gave their final presentations, solutions to created environmental contaminant spills in pockets around the state, to a classroom of peers who had grown close over the spring semester.


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Men's Ministry
Women's Ministry
Tuesdays at 5:30 p.m. in room #LL1.
GriefShare is a 13-week grief recovery seminar and support group. It is Christ-centered with a focus on grief topics associated with the death of a loved one. To register or for questions, call church office at 989.386.3381 for more information about our meetings.
For more information about the GriefShare international organization: GriefShare Website
Mothers of Preschoolers - MOPS
If you are a mom and need a group of ladies to encourage you, this is the group for YOU. Just come to the north entrance and we will take care of you and your child for TWO wonderful hours! We meet on the 1st and 3rd Wednesdays at 9:30 – 11:30 a.m. during the school year. Contact: Erika Dunn @ 989-339-1659 or Ella Mast @ 989-339-1069 with questions.
For more information about the MOPS international organization: MOPS Website


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Heart Pins Collab with Meg Does Pottery - Set of two pins - Ask me what colours I have left -
We have run out of stock for this item.
Why I made it:
A dream Collaboration with admired artist and fellow maker Meg from Meg Does Pottery.
The heart pins are made in clay and they totally match the Colours of Fall Winter 2019 Campus collection.
She created 10 colours in plain or with gold speckles.
Each pin is handmade and unique, and they should be handled gently and with love.
The set comes in a white box with a cotton liner.
Send me a note at checkout with your two preferred options.
You can mix and match colours based on availability.
How to style it:
Place them everywhere!
Blouses, hats, coats. Make a cluster of hearts to obtain a game of colours with your own colour base garment.
Related productsView all
Swiss Dot Cecilia Blouse
Tilda - Reversible Jumper


text: Isle Of Bute Saint 9,951 Report post Posted May 26, 2015 Lord Admiral Hill-Norton, Former Chief of Defence Staff, 5 Star Admiral of the Royal Navy, Chairman of the NATO Military Committee There are objects in our atmosphere, which are technically miles in advance of anything we can deploy, that we have no means of stopping them from coming here. There is a serious possibility that we are being visited and have been visited for many years by people from outer space, by other civilizations. Who they are, where they are from, and what they want should be the subject of rigorous scientific investigation and not be the subject of rubishing by tabloid newspapers Dr. Brian Oleary, Former NASA astronaut and Princeton Physics Professor There is abundant evidence that we are being contacted, that civilizations have been monitoring us for a very long time. That their appearance is bizarre from any type of traditional materialistic western point of view. That these visitors use the technologies of consciousness, they use toroids, they use co-rotating magnetic disks for their propulsion systems, that seems to be a common denominator of the UFO phenomenon Dr. Edgar Mitchell, 6th man to walk on the moon. Yes there have been crashed craft, and bodies recovered. We are not alone in the universe, they have been coming here for a long time Gordon Cooper, Former NASA Astronaut, Aeronautical Engineer and test pilot. One of the seven original Astronauts in Project Mercury, the first manned space program of the United States In my opinion I think they were worried that it would panic the public so they started telling lies about it. And then I think they had to tell another lie to cover their first lie, now they dont know how to get out of it. Now its going to be so embarrassing to admit that all these administrations have told so many untruths, it would be embarrassing getting out of it. There are a number of extraterrestrial vehicles out there cruising around 0 Quote Share this post Link to post Share on other sites


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Manual create account
The stomach is an important part in the digestive system of most animals. The second phase of digestion takes place in the stomach.
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Dnatube suggest users to have interest in drug testing, mesothelioma, insurance, medical lawyers.
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He took my innocence then abandoned me. Now I have to live with him…
Charlotte: It's been ten years since that night.
I've changed so much.
But William Jordan is exactly the same.
Gruff. Arrogant. A cold-hearted billionaire.
He's also the $exiest guy I've ever fricking seen.
I want to keep my head down, find a way to win my business back.
But someone's got it in for me.
And even though I hate to admit it, William's the key to figuring this all out.
Unless he's part of the problem…
William: Charlotte Miller is back in Pine Creek.
That's bad news.
She doesn't know the danger she's in.
Charlie's the only girl I've ever cared for.
Blue eyes, curves, a smile worth more than my billions.
But I can't fall for her again, can't let her make me vulnerable.
It could end up killing her.
Besides, any chance we might have had for happiness died when she dated my brother.
And I dated her best friend…
Yet, whenever we're together, sparks fly, flames re-ignite. I don't know how to resist.
Even worse, I don't know if I want to.
This second chance romantic suspense is so hot it'll have you reaching for ice. No cheating, no cliffhangers. Happily ever after guaranteed. $0.99 on Kindle.
Find more books like "Together Again" by Darcy Quinn on kobovskindlereviews.com. We feature both reviews of ereaders and discounted + free books on Kindle. Browse more books in the Romance.
Disclaimer: "Together Again" price was accurate on August 13th, 2019. However, Amazon Kindle book prices can and do change frequently and without notice. Before you buy a book on Kindle, it's best to double check the price. If you purchased a Kindle book that you thought was free, you can return it by following the Kindle book return instructions here.


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CB05. Christo Promotional Card Umbrella Project Japan/USA FREE UK P+P (Item number: #785468786)
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CB05. Christo Promotional Card Umbrella Project Japan/USA Single fold large format promotional cards for Christo's Umbrella project in Japan and the USA with maps for Tokyo and Los Angeles. 17.5cm x 23.5cm folded. One fold, tanning in places. Will be shipped as folded. Must be impossible to acquire today. CB05....
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OHARA DAVIES rolls up to Repton, the historic boxing club in London's east end, in a sleek black car. It gives off every outward appearance of success. "OD" has fought in big fights, he's made some money and has another payday looming tomorrow (Friday June 28) when he boxes Mexico's former world champion Miguel Vazquez at York Hall. But he is a perplexing character. He can play the villain, even the fool. His outrageous comments on social media ultimately saw him leave the Matchroom promotional stable. He has been humbled, and today speaks respectfully of his next opponent Vazquez. A confidence in himself however seemingly hasn't been diminished by defeats to both Josh Taylor and Jack Catterall.
"Vasquez," Ohara tells Boxing News. "He's a name and I believe that I'm one of the best boxers in the world and if I'm going to say something like that, if I'm going to believe something like that, I've got to feel it, I've got to get it back in my head. I'm not here to fight for six or eight rounds against a bum. I need to make some money, I need to be rich and boxing is the way that I'm going to do it."
The losses he's taken do still rankle. "It don't matter who you lose to, as a warrior, as a fighter when you lose a fight there is shame. It don't matter whether you lose against the best or against the worst, you lost and there is shame in that defeat. I still have shame to this day," Davies said.


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As of 8th May 2019 new applications will be placed on a waiting list.
With the advent and popularity of the Horsham Art Fair, the numbers of artists joining HAOS has grown considerably. In order that we can accommodate as many of our existing artists and creators as possible, in the forthcoming 2019 Art Fair, we have placed a moratorium on new ACTIVE ARTISTS applications that have access to exhibit ion the Horsham Art Fair. (an ACTIVE ARTIST has to have been a member for the previous year to be eligble to take a satnd in the Contemporary Art Fair in October)
HOWVERE, YOU CAN JOIN AS A FRIEND ARTIST…see bottom of this page
HAOS is a network of artists living or creating their art in the Horsham District.
We work in a variety of mediums and vary in styles and standard. Some are just discovering the joys of dabbling in paint or fabric, whilst others are professional or semi-professional artists. We aim to share information and ideas, give mutual support, and provide opportunities to exhibit and sell our artwork.
Annual Art Trail and Annual Art Fair
We have established two main events each year The HAOS Art Trail for two consecutive weekends in the Summer and The HAOS Contemporary Art Fair in the Autumn. Only HAOS artists can participate in these events. Because of the amount of organising and work involved interested artists will need to register their interest in taking part well in advance. Email is the main way of keeping in touch with what is going on, and networking with other HAOS artists as well as attending the monthly meeting.
Regular Meetings
We meet up about once a month usually on a Monday evening in the Lounge at the Methodist Church, London Road, Horsham, West Sussex RH12 1AN.
We are a self-help group so the proviso of joining HAOS is that you help out where you can during the year and share the work load of running the meetings, setting up and putting on events and helping with fundraising and other tasks that need to be done for such a group to run smoothly.
Roles and Responsibilities'
Each year roles, both lead and support, are re-allocated so the load is shared. The roles each artist performs are listed in a column within the Network list XL file sent at intervals to all HAOS artists. Both written guidance and support from other HAOS artists who have already done the task, are there to ease you into the new role. So all will feel supported. Over the course of the year requests will also be made for help to support those taking on these roles. We have no 'experts'; we all learn as we go along and build on information and results of previous years.
Our HAOS year runs 1 January to 31 December. We ask for an annual fee ( £15 for 2020) from each artist for the year to go toward venue hire cost and insurance for the venue for meetings. As an 'informal' group, we are not 'members' – we do not hold an AGM or have a membership fee.
HAOS Social Media
As wellas the Website where artists are invited be represented on, HAOS have a presence on Facebook, Twitter and Instagram.
Criteria for becoming an ACTIVE ARTITS or FRIEND ARTIST of HAOS
The criteria to belong to HAOS requires that;
- You are over 18 years of age
- You live within the Horsham District
- or you undertake, creating you Art in the Horsham District.
- Check the map below or sse this link to Google MAP to check if you live or create your art is on the Horsham District
- You agree to allowing your details displayed on the HAOS website (with image)
- As an ACTIVE ARTISTS you undertake to support the group by volunteering for one of the tasks
- You agree to pay the annual fee
If you you meet the criteria and wish to join as a FRIEND ARTISTS read the details and follow the link to join as a FRIEND ARTIST
(Please read our Privacy Policy)
Becoming a Friend of the Horsham Artists Open Studios allows you to attend our monthly meetings, network with other local artists and take part in the annual Horsham Contemporary Art Trail.
Our full membership numbers have swelled in recent years, to the point that we have had to place a moratorium accepting new members that might want to take part in the annual Horsham Art Fair, which can currently only provide stands for 47 artists.
However, in acknowledging that some of our artists do not wish to take part in the Art Fair, and maybe have little time to take on supporting roles in the group, which is something that we require of a full member, we have introduced the "Friends" membership.
NOTE, as with our full membership, you must be living or creating your Art in the Horsham District.
Benefits of being a Friend of Horsham Artists
- Reduced Annual Fee (for 2020 £10)
- Can attend as many or as little of the 10 monthly meetings per year
- Can participate in the Horsham Contemporary Art Trail
- Will receive the Art Matters News letter, and can promote their exhibition via the Newsletter
- Not obliged to volunteer for a support role, but certainly welcome to help us in any way possible
- Will have priority for becoming a full member as and when numbers allow. ( a waiting list will continue on first come basis)
- Access to the Horsham Artists closed Facebook Group
- Publicity opportunities via the Horsham Artists Facebook and Instagram pages
- A Friend is not entitled to take a stand in the Horsham Art Fair, but may be invited if space allows.
- A Friend does not have to attend a minimum number of monthly meetings to fulfill membership obligations
- A friend is not obliged to take on a voluntary, supporting role


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First of all Happy Holi. Last night when I and Ramya were discussing about holi we just tried to remember if we know anything about Holi. The conclusion was never did not know anything about the legends and rituals attached to it. So I went ahead and read on the net for what holi actually means and why it is celebrated. I would confidently say that 90% of my friends would not know any of this. So I thought I shall collectively post all the myths and legends about this festival in my blog.
Holi, the festival of colours, has many interesting legends and rituals attached to it. The mythological origins vary in different parts of the country, but the variety only gives one more reason to enjoy the festival!
Legends and Mythology
Legend 1 :
In Vaishnava theology, Hiranyakaship was the king of demons, and had received the boon of immortality from Lord Brahma. As his power and arrogance grew, he began objecting to people's belief in the divine power and demanded that they worship him instead. However, Hiranyakaship's son Prahlad was a devotee of Lord Vishnu. When he failed to destroy his son's beliefs despite placing him in near fatal situations, he ordered young Prahlad to sit on a pyre in his sister Holika's lap. Holika was blessed with a shawl, which would prevent the fire from harming her.
Prahlad happily followed his father's orders and prayed to the lord to save him. As the flames grew, to the spectators' amazement, the shawl flew from Holika to Prahlad. From that day on, the burning of Holika is celebrated as Holi.
Legend 2 :
In Vrindavan and Mathura, Holi is celebrated in memory of the divine love of Radha for Krishna. It is believed that when Lord Krishna was young, he often whined about his dark complexion and wondered why Radha was so fair. One day, his mother Yashoda playfully suggested that he can smear colour on Radha's face and change her complexion to any colour he wanted. Fascinated by the idea, Krishna proceeded to do so and thus, introduced the festival of colours.
Lord Krishna is believed to have popularised the festival by playing pranks on the gopis . The holi of Braj is famous all over India for its intimate connection with the divine deities and their love plays. Mythology also states that Holi is a celebration of the end of ogress Pootana, who tried to kill infant Krishna by feeding him poisonous milk.
Legend 3 :
Another Holi legend, which is popular in Southern India, revolves around Lord Shiva and Kaamadeva (God of lust). Kama's body was reduced to ashes by the force of an angry Shiva's third eye, when he shot a flower-draped arrow at him to disrupt his penance. On the tearful requests of Kama's wife Rati, the lord restored him, but only as a mental image, representing true love rather than physical lust. The Holi bonfire is believed to be celebrate this event.
Legend 4 :
Also popular is the fable of ogress Dhundhi who devoured innocent children in the kingdom of Raghu. She was ultimately chased away by the children's pranks on Holi. This is the reason that young boys are allowed to indulge in rowdiness on Holi.
Rituals of Holi
True Holi:
Fire or water? The emphasis is on ' Holika dahan' or lighting up of Holi on the eve of Holi. The origin of the Holi bonfire is attributed to the burning of demonesses like Holika and Putana . In places like Bihar and UP, ' Holika dahan' is also known as 'Samvatsar Dahan' . The concept of Samvatsar New Year varies in different provinces of our country.
The name says it all. Thandai is part and parcel of Holi celebrations. This refreshing and healthy drink is to be served amid the play of colours. In fact, Bhang thandai is used to set the mood for the festival of colours. Drinking thandai in this season also goes with the weather, as it acts as a coolant for people in North India, where the temperature is usually high at this time.
Vital ingredient: Bhang
There are no two ways about it — Bhang has become the official Holi drink. Culled from the leaves and buds of cannabis, the intoxicating bhang escalates the spirit of Holi. Lip-smacking bhang thandai , bhang pakoras and bhang vadas are some popular snacks people look forward to on Holi. The tradition of bhang on Holi is particularly popular in North India where Holi itself is celebrated with a zest not witnessed elsewhere.
Holi Mela
Holi melas are grand affairs and an ideal way for people who want to spend Holi in a different and more colourful way. Apart from being a source of entertainment, these fairs play a significant role in bringing people together. Colour is the main theme of any Holi fair. Everywhere, one can see aromatic colours kept in thalis or gunny bags. Even shopkeepers are seen with painted faces and hands to create the perfect aura.
Rang barse!
Splashing coloured water, smearing friends with gulal (coloured powder) and tossing water balloons on each other, playing with colours will be the order of the morning and any offence caused to anyone is washed away.
The beautiful, intricate patterns made from coloured rice powder or sand are considered auspicious. Traditionally, rangoli is made by unmarried girls of the family.
Say it in style!
Tray-loads of sweets and colours are distributed to near and dear ones. Blessings are exchanged and gulal is used to anoint the feet of elders or the forehead of a younger person. Other gifts, such as puja thalis, pichkaries (long metallic syringes used to splash water), packets of colour, chocolates can also be gifted.


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Published on : Tuesday, February 26, 2019
Indian budget carrier IndiGo is looking China, Vietnam, Myanmar and Saudi Arabia, among other countries, as the airline embarks on expanding its international network.
In a communication to employees on Monday, IndiGo's CEO Ronojoy Dutta said that the airline would be looking at ambitious expansion in the international market and utilise around 50 per cent of its new capacity on that market. IndiGo is the country's largest domestic carrier with a market share of 42.5 per cent in January. The carrier, which has more than 200 planes, operates over 1,300 daily flights.
The carrier, which has more than 200 planes, operates over 1,300 daily flights. In the international market, they will be looking at an ambitious expansion with approximately 50 per cent of our new capacity directed at international markets. They will be looking to add new service to countries such as China, Vietnam, Myanmar, Turkey, Saudi Arabia, CIS (Commonwealth of Independent States) countries and also add frequencies in existing routes. According to him, the airline would continue to build air-infrastructure to smaller cities.
Tags: Airline News, china, indigo, myanmar


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"And we know that in all things God works for the good of those who love Him, who have been called according to His purpose." - Romans 8:28
When we find ourselves in a very dark season of life, we long for someone to put an arm around us, assuring us that everything will be okay. We want assurance that our world is orderly and stable—not spinning off into chaos. We want to know that God is at the center of our suffering, not only holding our lives together but also holding us. In Romans 8:28, we have the massive promise of that assurance: "We know that in all things God works for the good of those who love Him, who have been called according to His purpose."
This is true no matter what we face in life. The robust hope of the believer is not that we will escape hurts and sorrows, but that God will make every one of them an instrument of His mercy to do us good—both now and in eternity.
Taken from Joni's A Spectacle of Glory devotional.
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Hippy Christmas, 1970s Style! 7-8 December 2019
Hey Naturi Friends! Its peak season for us nudies, and what better reason to don our birthday suits than to celebrate Christmas together! Come along to Naturi on the weekend of 7-8 December, for some good vibes, ultra cool 70s dance music, and much nudey silliness! See if you can find something psychedelic to wear … More Hippy Christmas, 1970s Style! 7-8 December 2019


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