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Opinion ARTICLE
An Importin Code in neuronal transport from synapse-to-nucleus?
- RG Neuroplasticity, Leibniz Institute for Neurobiology, Magdeburg, Germany
The principle cells of the brain- neurons- express more genes than any other cell type. As many rudimentary processes of the brain, such as long-lasting changes in synaptic efficacy, involve alterations to the expression of genes, the characterisation of proteins and processes that influence transcription is a high priority in neuroscience. An emerging system capable of transducing signals that likely influence transcription is synapse-to-nucleus macromolecular protein shuttling, in which synaptic proteins are relayed to the nucleus in a complex with importins (also referred to by their gene name: Karyopherins/KPNs) and molecular motors such as dynein (Jordan and Kreutz, 2009, Figure 1C). Despite a central position in a neuronal process capable of altering transcription, there is a dearth of research into importin function in neurites. In this opinion paper we summarize neuronal importin understanding to date, present novel ideas relating to their neuronal function and highlight the reductionist nature of the classical description of nuclear import with the specific example that complex composition is likely much more intricate than is being considered.
Figure 1. Importin structures, canonical and non-caconocal nuclear import and The Importin Code. (A) The general domain structure of importin-α and importin-β (1) importin-α is composed of an N-terminus importin-β binding domain (IBB) followed by 10 armadillo (ARM) repeats- cargo proteins typically bind at either ARMs 2–4 (monopartite binding at the major site) or at ARMs 2–4 and ARMs 7–8 (bipartite binding at the major and minor sites, respectively). Importin-β isoforms are comprised of 19-20 HEAT repeats. (B) Nuclear import in neurons from the soma, axons and dendrites/synapses: all of which may incorporate The Importin Code and converge in the nucleus where transcriptional alterations can be induced. (1) The classical description of nuclear import. The trimeric complex (importin-α, importin-β and cargo) translocates from the soma, across the nuclear pore complex (NPC) at the nuclear envelope (NE) and into the nucleus where Ran-GTP binds importin-β, liberating components of the complex. Importin-β likely transports back to the cytoplasm, whereas the cargo and importin-α may perform nuclear functions. (2) Nuclear import from axons. A complex composed of importin-α, importin-β and cargo (trimeric complex shown) is attached to microtubules via the molecular motor dynein, which drives the complex to the nucleus. (3) Synapse-to-nucleus transport. Importin-α and cargo proteins likely assemble in the synapse and are transported to the nucleus along microtubules by the molecular motor dynein. Importin-β is incorporated into the complex prior to NPC passage. (C) The Importin Code. (1) Classically described importin codes: the trimeric complex and importin-β alone with a cargo, (2) importin codes that are frequently attached as caveats to the classically described complex compositions. Importin-α can mediate cargo transport alone, 2 importin-β (s) can mediate transport, cargos can execute their own nuclear import independently of importins and importins may carry 2 cargos. (3) Possible importin codes incorporating the newly proposed non-importin family member cargo-specific importins (NICSIs). (4) Highly speculative importin codes based on the possibility of NICSI involvement in nuclear import and on potential importin-α dimers.
The Classical Function of Importins
Whilst proteins smaller than 40 kDa are free to diffuse in and out of the nucleus via the nuclear pore complex (NPC), proteins larger than this require importins. Two related families of importins have been described: Importin-α and importin-β. In humans, there are 7 importin-α isoforms (1–7) and 19 importin-β isoforms (Yasuhara et al., 2009; Xu et al., 2010; Zienkiewicz et al., 2013, Figure 1A). Importin-α subtypes comprise of an importin-β binding (IBB) domain followed by 10 armadillo (ARM) repeats that organize into 3 alpha helices (Conti et al., 1998; Kelley et al., 2010). Importin-β subtypes are composed of 19–20 HEAT repeats that arrange into a super helicoidal molecule (Xu et al., 2010). The classical pathway best describes importin understanding in nuclear import (Figure 1B1). This starts with the formation of a trimeric complex outside of the nucleus consisting of a cargo protein bound to an importin-α with its nuclear localisation signal (NLS) and the importin-α isoform bound to an importin-β with its N-terminal IBB domain (Goldfarb et al., 2004). Once formed in the cytoplasm, the trimeric complex translocates to the nucleus, either passively via diffusion or actively with the retrograde molecular motor dynein (Goldfarb et al., 2004). At the nuclear envelope, importin-β mediates the passage of the NPC, probably due to mediation with NPC-proteins FG-nucleoporins (Lott and Cingolani, 2011) and following entry into the nucleus the 100-fold higher concentration of Ran-GTP binds to importin-β, liberating the cargo for the second leg of their nuclear mission and the importins for translocation back to the cytoplasm (Conti and Izaurralde, 2001; Goldfarb et al., 2004; Stewart, 2007; Mason and Goldfarb, 2009; Ch'ng and Martin, 2011, Figure 1C). There are several exceptions to the classical description (to be discussed) but the involvement of importins in the nuclear import of cargo proteins is clear. It is also known that each importin isoform has a unique catalog of interacting partners and distinct subcellular expression (Nadler et al., 1997; Kelley et al., 2010; Schaller et al., 2014). As a result of these findings, a parsimonious hypothesis emerged: Importins function as adaptor proteins, linking distinct cargo proteins to nuclear import complexes. Therefore, by changing the expression of importins contributing to nuclear import—which is induced by activity—the nuclear proteome is shuffled, with likely alterations in transcriptional output and cellular phenotypes. As long-term forms of synaptic plasticity require such alterations in transcriptional output from the nucleus, the possibility that importins are central in this neuronal process is obvious (Thompson et al., 2004; West and Greenberg, 2011).
Importins in Synapse-To-Nucleus Transport
Importins exhibit a widespread distribution in dendrites, axons and synapses (Thompson et al., 2004; Jeffrey et al., 2009; Higashi-Kovtun et al., 2010). Evidence for importins having unique interacting partners in neurons comes from the finding that knockdown of importin-α1 results in improper nuclear accumulation of PER in drosophila neurons, whereas importin-α2 or importin-α3 knockdown did not have the same effect (Jang et al., 2015). Crucially, interactions and subcellular localisations of importins are altered by neuronal activity (Hanz et al., 2003; Thompson et al., 2004; Perlson et al., 2005; Dieterich et al., 2008; Jeffrey et al., 2009). This was first shown with the finding that importin-α and importin-β isoforms interact with the retrograde molecular motor dynein in the axoplasm of rats and that nerve injury induces increased association of importin-β 1 with dynein, presumably to rapidly convey the new neuronal information to the nucleus using cargo proteins such as ERK1-2 (Hanz et al., 2003; Perlson et al., 2005). This axon-to-nucleus communication of the new neuronal environment is made more efficient by the local translation of importin-β (Hanz et al., 2003). At a similar time, it emerged that importins redistribute from synaptic sites to the nucleus following the activation of synaptic receptors and that this redistribution was required for the persistence of long-term forms of synaptic plasticity (Thompson et al., 2004). Spatial and functional aspects of neuronal importins were refined with the finding that importin-α1 redistributes to the nucleus with synapse-to-nucleus messenger protein Jacob following synaptic activity (Dieterich et al., 2008) and that importin-α5 (named importin-α1 in the paper due to use of previous nomenclature) is liberated from basal associations with NMDARs following activation of these receptors, allowing nuclear accumulation (Jeffrey et al., 2009). These seminal studies give rise to the hypothesis that importins function as adaptor proteins in the mediation of cargo-specific activity-dependent synapse-to-nucleus transport. There are several caveats concerned with this description. Rather than just governing nuclear localization, neuronal importins control protein expression across several subcellular localisations: Importin-β 11 retains pMAD in the synapse and importin-α1 (importin-α2 in the paper due to unique terminology use) keeps Oct6/Brn2 in the cytoplasm (Higashi-Kovtun et al., 2010; Yasuhara et al., 2013). A strong candidate for how importins achieve this is that they maintain the current state of post-translational modifications on proteins. This is supported by the finding that enhanced neuronal cell death in importin-α5 knockout mice is rescued by the viral transfection of constitutively active STAT3 (pSTAT3), implying that importin-α5 may protect STAT3 from dephosphorylation (Ben-Yaakov et al., 2012). Emerging non-canonical functions vehemently underscore the inability of the conventional "adaptor protein" description to sufficiently depict importin functions. So, how reliably does the classical description represent importin function in nuclear import?
Limitations of the Classical Pathway: Proposition of The Importin Code
The classical importin pathway relies on the trimeric complex (importin-β-importin-α-Cargo, see Figure 1C1), yet complex composition is known to be much more flexible. Nuclear import of cargo can be facilitated by a single importin-α (Kotera et al., 2005), single or multiple importin-β (s) (there are 11 known importin-β heterodimers) (Jäkel et al., 1999; Harel and Forbes, 2004; Xu et al., 2010) or a mechanism independent of any importin (Fagotto et al., 1998) and it remains possible that importins can carry 2 cargos at a time (Hodges et al., 2005) (Figure 1C2). As complex composition is acknowledged to be variable, what other combinations might exist? In their unraveling of the nuclear import complex involved in circadian regulation (importin-α1-TIM1-PER1) (Jang et al., 2015) find that TIM1 is evolutionarily homologous with importins and propose that it is a PER-specific importin. Likewise, Marcora and Kennedy (2010) predict that, due to similar primary and deduced secondary structure of Huntingtin (Htt) with importin-β 1, Htt may be an NFκB-specific importin in a complex composed of importin-α2, Htt and NFκB. The proposition of non-importin-family-member cargo-specific importins (NICSI's) is novel and warrants validation but it isn't a giant leap, rather, it is an extension of the existing concept of cargo-specificity in nuclear import (Figure 1C3). Because of homology to importin-β in both of the above examples, the authors predict that the NICSI replaces the importin-β in the transport complex. However, Jang et al. (2015) found that removal of the IBB domain of importin-α1 did not prevent binding of importin-α1 to TIM1, suggesting that NICSIs act as cargos to importin-α(s) and that transport complexes could feasibly be composed of importin-α, NICSI and cargo with or without an importin-β. Based on sequence similarities of over 20% identical to importin-β 1 (importin-β family members typically have between 15 and 20% homology) there are at least 5 more easily-identifiable NICSIs (MIP, BRAT1, TNPO2, STK36, SPAG6) (elucidated via BLAST search on NCBI database). As TIM1 and Htt do not meet this criterion, we expect that there are more yet-to-be-discovered NICSIs based on evolutionary homology and primary/secondary/tertiary structures. We would expect that NICSIs have unique interacting partners, in the same manner as importin-α isoforms. Other potential transport complex combinations include those expressing interactions between importin-α isoforms due to the finding that importin-α1 interacts with importin-α3 and importin-α7, and importin-α4 interacts with importin-α7 in a non-neuronal model (Kristensen et al., 2012). Assuming that some importin-α isoforms can combine with each other in neurons and that there are a number of NICSIs that are components of synapse-to-nucleus complexes, the number of potential importin-β, importin-α, importin-α and NICSI combinations becomes huge (in the order of thousands). We do not expect that all of the thousands of potential importin combinations exist but we suggest that there is a much greater number of importin combinations than is currently being portrayed by the classical description (Figure 1C4). Our prediction is that importins are involved in a highly regulatory system in cells with the expression of The Importin Code: Unique importin combinations that provide tight control over synaptic protein selection for nuclear import and govern cellular phenotypes. Just as a barcode can read and decode a specific item into the readout of a price, if we could catalog and read importin codes, we could decode synaptic proteins for nuclear import into the readout of a cellular phenotype. Very little is known about the dynamics of proteome expression in the synapse but it is estimated that there are ~2700 synaptic proteins and that ~10% possess bona fide NLSs (Jordan et al., 2004, 2007; Pielot et al., 2012). As the possession of a NLS infers ability to be translocated to the nucleus, the scope for regulating which synaptic proteins are to be transported to the nucleus is very high. Neurons thus require a highly specific system capable of selecting potentially between more than 200 synaptic proteins for activity-dependent nucleocytplasmic shuttling in accordance with the current environment. With a possibility to generate this number of combinations, The Importin Code has the capacity to be such a governing system.
Whilst the hypothesis that importins function as adaptor proteins in the mediation of cargo-specific synapse-to-nucleus transport for key brain processes such as long-term forms of synaptic plasticity is informative and useful, it has several important caveats: Non-canonical importin functions are emerging and the role of importins in transport cargo specificity is likely being underestimated. The Importin Code best depicts the grand cargo specificity that importins provide to tightly regulate synaptic protein selection for nuclear import that ultimately governs cellular phenotypes.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The work in the lab of MK was supported in recent years by grants from the Alexander-von-Humboldt Foundation (AvH), Bundesministerium für Forschung und Technologie (BMBF), Deutscher Akademischer Austauschdienst (DAAD), Deutsche Forschungsgemeinschaft (DFG), Leibniz Foundation (Pakt für Forschung), EU-FP7 MC-ITN NPlast, CBBS and Schram Foundation.
Ben-Yaakov, K., Dagan, S. Y., Segal-Ruder, Y., Shalem, O., Vuppalanchi, D., Willis, D. E., et al. (2012). Axonal transcription factors signal retrogradely in lesioned peripheral nerve. EMBO J. 31, 1350–1363. doi: 10.1038/emboj.2011.494
Ch'ng, T. H., and Martin, K. C. (2011). Synapse-to-nucleus signaling. Curr. Opin. Neurobiol. 21, 345–352. doi: 10.1016/j.conb.2011.01.011
Conti, E., Izaurralde, and E. (2001). Nucleocytoplasmic transport enters the atomic age. Curr. Opin. Cell. Biol. 13, 310–319.
Conti, E., Uy, M., Leighton, L., Blobel, G., and Kuriyan, J. (1998). Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell 94, 193–204. doi: 10.1016/S0092-8674(00)81419-1
Dieterich, D. C., Karpova, A., Mikhaylova, M., Zdobnova, I., Konig, I., Landwehr, M., et al. (2008). Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus. PLoS Biol. 6:e34. doi: 10.1371/journal.pbio.0060034
Fagotto, F., Gluck, U., and Gumbiner, B. M. (1998). Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin. Curr. Biol. 8, 181–190. doi: 10.1016/S0960-9822(98)70082-X
Goldfarb, D. S., Corbett, A. H., Mason, D. A., Harreman, M. T., and Adam, S. A. (2004). Importin alpha: a multipurpose nuclear-transport receptor. Trends Cell. Biol. 14, 505–514. doi: 10.1016/j.tcb.2004.07.016
Hanz, S., Perlson, E., Willis, D., Zheng, J. Q., Massarwa, R., Huerta, J. J., et al. (2003). Axoplasmic importins enable retrograde injury signaling in lesioned nerve. Neuron 40, 1095–1104. doi: 10.1016/S0896-6273(03)00770-0
Harel, A., and Forbes, D. J. (2004). Importin beta: conducting a much larger cellular symphony. Mol. Cell 16, 319–330. doi: 10.1016/j.molcel.2004.10.026
Higashi-Kovtun, M. E., Mosca, T. J., Dickman, D. K., Meinertzhagen, I. A., and Schwarz, T. L. (2010). Importin-beta11 regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the drosophila neuromuscular junction. J. Neurosci. 30, 5253–5268. doi: 10.1523/JNEUROSCI.3739-09.2010
Hodges, J. L., Leslie, J. H., Mosammaparast, N., Guo, Y., Shabanowitz, J., Hunt, D. F., et al. (2005). Nuclear import of TFIIB is mediated by Kap114p, a karyopherin with multiple cargo-binding domains. Mol. Biol. Cell 16, 3200–3210. doi: 10.1091/mbc.E04-11-0990
Jäkel, S., Albig, W., Kutay, U., Bischoff, F. R., Schwamborn, K., Doenecke, D., et al. (1999). The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1. EMBO J. 18, 2411–2423. doi: 10.1093/emboj/18.9.2411
Jang, A. R., Moravcevic, K., Saez, L., Young, M. W., and Sehgal, A. (2015). Drosophila TIM binds importin alpha1, and acts as an adapter to transport PER to the nucleus. PLoS Genet. 11:e1004974. doi: 10.1371/journal.pgen.1004974
Jeffrey, R. A., Ch'ng, T. H., O'Dell, T. J., and Martin, K. C. (2009). Activity-dependent anchoring of importin alpha at the synapse involves regulated binding to the cytoplasmic tail of the NR1-1a subunit of the NMDA receptor. J. Neurosci. 29, 15613–15620. doi: 10.1523/JNEUROSCI.3314-09.2009
Jordan, B. A., Fernholz, B. D., Boussac, M., Xu, C., Grigorean, G., Ziff, E. B., et al. (2004). Identification and verification of novel rodent postsynaptic density proteins. Mol. Cell. Proteomics 3, 857–871. doi: 10.1074/mcp.M400045-MCP200
Jordan, B. A., Fernholz, B. D., Khatri, L., and Ziff, E. B. (2007). Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons. Nat. Neurosci. 10, 427–435. doi: 10.1038/nn1867
Jordan, B. A., and Kreutz, M. R. (2009). Nucleocytoplasmic protein shuttling: the direct route in synapse-to-nucleus signaling. Trends Neurosci. 32, 392–401. doi: 10.1016/j.tins.2009.04.001
Kelley, J. B., Talley, A. M., Spencer, A., Gioeli, D., and Paschal, B. M. (2010). Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. BMC Cell Biol. 11:63. doi: 10.1186/1471-2121-11-63
Kotera, I., Sekimoto, T., Miyamoto, Y., Saiwaki, T., Nagoshi, E., Sakagami, H., et al. (2005). Importin alpha transports CaMKIV to the nucleus without utilizing importin beta. EMBO J. 24, 942–951. doi: 10.1038/sj.emboj.7600587
Kristensen, A. R., Gsponer, J., and Foster, L. J. (2012). A high-throughput approach for measuring temporal changes in the interactome. Nat. Methods 9, 907–909. doi: 10.1038/nmeth.2131
Lott, K., and Cingolani, G. (2011). The importin beta binding domain as a master regulator of nucleocytoplasmic transport. Biochim. Biophys. Acta 1813, 1578–1592. doi: 10.1016/j.bbamcr.2010.10.012
Marcora, E., and Kennedy, M. B. (2010). The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-kappaB from the synapse to the nucleus. Hum. Mol. Genet. 19, 4373–4384. doi: 10.1093/hmg/ddq358
Mason, D. A., and Goldfarb, D. S. (2009). The nuclear transport machinery as a regulator of drosophila development. Semin. Cell. Dev. Biol. 20, 582–589. doi: 10.1016/j.semcdb.2009.02.006
Nadler, S. G., Tritschler, D., Haffar, O. K., Blake, J., Bruce, A. G., and Cleaveland, J. S. (1997). Differential expression and sequence-specific interaction of karyopherin alpha with nuclear localization sequences. J. Biol. Chem. 272, 4310–4315. doi: 10.1074/jbc.272.7.4310
Perlson, E., Hanz, S., Ben-Yaakov, K., Segal-Ruder, Y., Seger, R., and Fainzilber, M. (2005). Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron 45, 715–726. doi: 10.1016/j.neuron.2005.01.023
Pielot, R., Smalla, K. H., Müller, A., Landgraf, P., Lehmann, A. C., Eisenschmidt, E., et al. (2012). SynProt: a database for proteins of detergent-resistant synaptic protein preparations. Front. Synaptic Neurosci. 4:1. doi: 10.3389/fnsyn.2012.00001
Schaller, T., Pollpeter, D., Apolonia, L., Goujon, C., and Malim, M. H. (2014). Nuclear import of SAMHD1 is mediated by a classical karyopherin alpha/beta1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation. Retrovirology 11:29. doi: 10.1186/1742-4690-11-29
Stewart, M. (2007). Molecular mechanism of the nuclear protein import cycle. Nat. Rev. Mol. Cell Biol. 8, 195–208. doi: 10.1038/nrm2114
Thompson, K. R., Otis, K. O., Chen, D. Y., Zhao, Y., O'Dell, T. J., and Martin, K. C. (2004). Synapse to nucleus signaling during long-term synaptic plasticity; a role for the classical active nuclear import pathway. Neuron 44, 997–1009. doi: 10.1016/j.neuron.2004.11.025
West, A. E., and Greenberg, M. E. (2011). Neuronal activity-regulated gene transcription in synapse development and cognitive function. Cold. Spring. Harb. Perspect. Biol. 3:a005744. doi: 10.1101/cshperspect.a005744
Xu, D., Farmer, A., and Chook, Y. M. (2010). Recognition of nuclear targeting signals by karyopherin-beta proteins. Curr. Opin. Struct. Biol. 20, 782–790. doi: 10.1016/j.sbi.2010.09.008
Yasuhara, N., Oka, M., and Yoneda, Y. (2009). The role of the nuclear transport system in cell differentiation. Semin. Cell Dev. Biol. 20, 590–599. doi: 10.1016/j.semcdb.2009.05.003
Yasuhara, N., Yamagishi, R., Arai, Y., Mehmood, R., Kimoto, C., Fujita, T., et al. (2013). Importin alpha subtypes determine differential transcription factor localization in embryonic stem cells maintenance. Dev. Cell 26, 123–135. doi: 10.1016/j.devcel.2013.06.022
Zienkiewicz, J., Armitage, A., and Hawiger, J. (2013). Targeting nuclear import shuttles, importins/karyopherins alpha by a peptide mimicking the NFkappaB1/p50 nuclear localization sequence. J. Am. Heart Assoc. 2:e000386. doi: 10.1161/JAHA.113.000386
Keywords: importins, synapse, nucleus, long-distance transport, gene expression
Citation: Lever MB, Karpova A and Kreutz MR (2015) An Importin Code in neuronal transport from synapse-to-nucleus? Front. Mol. Neurosci. 8:33. doi: 10.3389/fnmol.2015.00033
Received: 16 June 2015; Accepted: 06 July 2015;
Published: 21 July 2015.
Edited by:Carlo Sala, CNR Institute of Neuroscience, Italy
Reviewed by:Eran Perlson, Tel Aviv University, Israel
Copyright © 2015 Lever, Karpova and Kreutz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Michael R. Kreutz, email@example.com


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Nutritional Status and Considerations for Patients Diagnosed with a Gastroenteropancreatic Neuroendocrine Tumor: Preliminary Baseline Characteristics from the Nutrition in NETs Study Abstract #2178
Introduction: Gastroenteropancreatic neuroendocrine tumours (GEP NET) cause various symptoms impacting on nutritional status and diet. Published data indicates up to 25% of GEP NET patients are malnourished, and dietary change is prevalent. Further research is required to guide nutrition recommendations.
Aim(s): Nutrition in NETs is a prospective longitudinal study aiming to describe the impact of GEP NETs on patient's nutritional status and quality of life. Baseline characteristics of study participants are discussed.
Materials and methods: Patients diagnosed with a GEP NET were recruited upon initial attendance to the Peter MacCallum Cancer Centre (Melbourne, Australia). Recruitment commenced in July 2017 and is ongoing. At baseline, participant demographics and patient-reported outcome data was recorded (dietitian contact, dietary habits, and symptoms). Nutritional status was measured using the patient-generated subjective global assessment (PG-SGA).
Conference: 15th Annual ENETS conference (2018)
Category: Medical treatment - others, not specified
Presenting Author: Erin Kennedy
Authors: Kennedy E, Kiss N, Michael M, Gough K, Drosdowsky A, Krishnasamy M
Keywords: nutrition, malnutrition, diet, neuroendocrine
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Northwest Woods is between Highway 183 and Parmer Lane, with Anderson Mill Road connecting the two. These main roads mean that residents quickly travel to Cedar Park, Round Rock, and all parts of Austin.
Northwest Woods Schools
The highly regarded Round Rock ISD serves the students of Northwest Woods. Younger students attend Live Oak Elementary (K-5), while older students attend Deerpark Middle (6-8) and McNeil High School (9-12). The high school enjoys an excellent reputation for award-winning music programs in band and choir, and championship sports teams. Private school options include a 2-mile drive to Trillium Montessori (Infant-6 years) and a less than 5-mile drive to Hill Country Christian School of Austin (PK-12).


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|Internal white LED light, with touch type switch, you can adjust the brightness according to ambient light changes.
|2) Touchable Dimmable the white and warm light.
|3) With USB charging port, make sure that you have long-term use on any occasion.
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|9) It's widely applied to indoor and outdoor video film shooting,live broadcast,fashion,wedding party,beauty make up,salon,advertising etc.


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Room RoomsGuest Guests. Please edit your dates or find hotels nearby. Give this hotel a call to find out their prices or check out their website for more contact details. In what city or town was your first job? To continue please answer the following security validations questions. Photos All Photos Please Review and Confirm Your Answers. In what city or town does your nearest sibling live? Towels were a little dingy.
United States; Kentucky (KY); Benton; Benton Hotels.
Top 10 Hotels in Benton, Kentucky
View map #1 Best Value of 16 places to stay in Benton Quality Inn and Suites Benton – Draffenville. Instant savings on Benton hotels. Benton has lots of places to visit including Kentucky Lake, Kentucky Opry, and Mike Miller County Park. Shop for 60 deals. See discounts for hotels & motels in or near Benton, KY.
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Wifi worked without a hitch, room was quiet, beds were nice, overall worth the budget price. Show reviews that mention.
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Zeltlager mit lagerfeuer gitarre
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Things to Know Good management. Photos All Photos Pet Policy. Please note the following:. Benton Inn - Benton, KY. Get Directions.
Book now at the Quality Inn and Suites Benton – Draffenville hotel in Benton, KY near Kentucky Lake and Miller State Park. Enjoy free amenities during your. Priceline™ Save up to 60% Fast and Easy 【 Benton Hotels 】 Get deals at Benton's best hotels online!
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Edit Dates. Please edit your dates or find hotels nearby. Free self parking is available onsite.
Try HotelPlanner. Corporate Code. Friendly staff, room was clean and air conditioning worked.
Benton Inn Kentucky hotel near Clarks River National Wildlife Refuge and more. Enjoy the features of the property including Free Wi-Fi, TV, Microwave and. Benton is known for its countryside, waterfalls, and forests.
Quality Inn and Suites Benton Kentucky Hotel Information
Find hotels and other accommodations near Mike Miller County Park, Kentucky Lake, and Kentucky.
If you are here on business, we are near a number of industrial plants. In what city or town was your first job?
General Information. Would you like to save as your currency permanently or for this visit only?
Hotel Quality Inn & Suites Benton – Draffenville, Benton
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Benton Inn - Benton, KY. Smoking Policy.
Find Hotel Deals. Seemed that the bathroom had been refurbished Lighting, Circulation needs ceiling fans Air Conditioner was very old, No coffee in the room or at the office, no ice machines.


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9 Lessons Learned:
Benefits of Contracting Solar Companies.
It is crucial to realize that energy efficiency is among the things that many people will need to do when they want to proper energy flow. You can now have the chance to enhance energy efficiency in your house when you have decided that you want to make these possible. It is crucial to note that solar panels are an excellent solution for this power backup. Research has shown that solar energy is another alternative when you need to have some energy backup since the weather is constantly changing and this could affect the power supply. One of the reasons why solar energy is the fact that this is an occurring natural commodity and always will be present since it comes from the sun.
However, some people do not know how to tap in this energy and you ought to ensure that you are reading more through this article to learn how you can make this possible. You will now be able to tap solar power when you have decided that you want to use solar energy for your needs. When you think of having solar panels installed, you must learn that there are many solar panels companies keen on making sure that your needs are addressed. You ought to ensure that you are dealing with the best solar installation services providers like local solar contractors when you are set that you would love to get solar energy services from the experts.
When you focus on using this solar installation services, you are assured that this will be an ideal solution for your needs and you must learn that getting local solar contractors will have some few gains. It is essential that you keep learning more through this article to discover more about some of these benefits a spotted here in this blog. It is crucial to note that working with the solar companies to deal with the solar installation services will be done correctly and more so the work will be done on time. You must realize that there is a lot of work that is involved in this process and you should understand that working with the experts will be tremendous and you will not have to be stressed about the services that you need.
It is confirmed that energy efficiency will be promoted when you have the best solar panels installed by the experts in the market. It is has been noted that these experts are there to help with the installation services and therefore they can get the work done on time and more correctly. In addition, you are assured that having a local solar contractor will see you get the best and more so high quality panels that you would have wanted to get on time.
Cite: http://tiny.cc/


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How particular has Southeast Asia's experience of educational development been, and has this led to an identifiably distinct Southeast Asian approach to the provision of education? Inquiry into these questions has significant consequences for our understanding of the current state of education in…
Hardback – 2018-11-07
Routledge Studies in the Modern History of Asia
The linguistic origin of the term Dalit is Marathi, and pre-dates the militant-intellectual Dalit Panthers movement of the 1970s. It was not in popular use till the last quarter of the 20th century, the origin of the term Dalit, although in the 1930s, it was used as Marathi-Hindi translation of the…
Hardback – 2018-11-05
Routledge Contemporary South Asia Series
The study of urbanization in Southeast Asia has been a growing field of research over the past decades. The Routledge Handbook of Urbanization in Southeast Asia offers a collection of the major streams and themes in the studies of the cities in the region. A focus on the urbanization process rather…
Hardback – 2018-10-30
At this western corner of the confluence of the Bay of Bengal and the busy river Hooghly, West Bengal in eastern India lies a geography that has hosted many outsiders – traders, merchants, colonial masters, missionaries and wanderers. This book is fundamentally concerned with the relations among…
Hardback – 2018-10-30
Routledge Research on Urban Asia
Analyses of the Sri Lankan civil war (1983–2009) overwhelmingly represent it as an ethnonationalist contest, prolonging postcolonial arguments on the creation and dissolution of the incipient nation-state since independence in 1948. While colonial divide-and-rule policies, the rise of…
Hardback – 2018-10-17
Routledge/Asian Studies Association of Australia (ASAA) South Asian Series
This set brings together a collection of classic works on Tibet. In four volumes, they cover the key areas of interest in the country: its religion, development as a nation, and its contact with the West. Drawing on a great depth of knowledge and research, these titles were written by experts in…
Hardback – 2018-10-17
Routledge Library Editions: Tibet
Indigenous sustainability and environmental management cannot be understood apart from a community, its traditions, and ways of practices. Interest in Indigenous environmental sustainability has grown steadily in past years, reflecting traditional cultural perspectives about the environment and…
Hardback – 2018-10-17
Routledge Contemporary South Asia Series
Political violence has remained an integral part of South Asian society for decades. The region has witnessed and continued to encounter violence for achieving political objectives from above and from below. Violence is perpetrated by the state, by non-state actors, and used by the citizens as a…
Paperback – 2018-10-03
Examining the relationships between activists and the changing political environment, this book analyzes the trajectories of three major social movements in Taiwan during the country's democratic transition between 1980 and 2000. In doing so, it explores why the labor and environmental movements…
Hardback – 2018-10-02
Routledge Research on Taiwan Series
Dr. Hossen carried out an exceptional program of research in Bangladesh which focused on water governance in relation to human rights, international water law and environmental sustainability. His major argument is that eco-agricultural system encounters major disruptions due to a number of factors…
Paperback – 2018-09-27
This book explores the topics of English accents and pronunciation. It highlights their connections with several important issues in the study of English in the world, including intelligibility, identity, and globalization. The unifying strand is provided by English pronunciation models: what do…
Paperback – 2018-09-27
This 13-volume collection of previously out-of-print titles reissues some key works in the study of Mao Zedong's huge influence on China – its politics, economics and development into the power that it is today. Foreign policy, the Cultural Revolution, the fate of opponents, Chinese Marxist thought…
Hardback – 2018-09-13
Routledge Library Editions: China Under Mao


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EasyDiagnosis offers automatic online medical diagnosis for consumers. Answer questions about your signs and symptoms and our expert systems come up with the most likely diagnoses.
PPIs are often the preferred GERD treatment. They can heal the esophageal lining and treat GERD symptoms, but they can cause constipation. There are a few ways to manage constipation.
Welcome to Johns Creek Gastroenterology. Johns Creek Gastroenterology specializes in the diagnosis, treatment and prevention of gastrointestinal diseases for patients with disorders of the gastrointestinal tract and the liver in North Atlanta, Georgia.
10.05.2015 · Ways to deal with indigestion; Jaggery, a safer substitute for sugar? Does your diet contain too much of sugar? How to shop smart for healthy grocery
Cayenne Pepper for Irritable Bowel Syndrome &. – Chronic red pepper powder ingestion may be an effective treatment for IBS and chronic dyspepsia (indigestion), both of which can arise from food poisoning.
Mild constipation can be easily treated by changes in your diet. First, take in more fluids. Go for fruit juices or just water and ensure you took a lot before and after your meals.
How to use this website. Step 1 – The Move to Improve site is designed to provide advice and information to help you manage aches and pains. This includes tips and exercises which you can do at home and in lots of cases these will, in time, make the condition better.
Testing Stomach Acid With Beets Bears Battlestar Shirt Feb 25, 2014. All you need is about half of a raw beet, and the stomach to glance into. transit time," also known as constipation—a common result of the beet
CHECK YOUR STOMACH FOR SUFFICIENT HYDROCHLORIC ACID. To test for sufficient hydrochloric acid – You need betaine hydrochloride tablets plus enzymes – they are available from health food shops.
Magnesium citrate (Citrate of Magnesia, Citroma) is an OTC medicine that retains water in the intestines to relieve constipation. A magnesium citrate supplement is used for treating heartburn. Side effects include abdominal cramps, diarrhea, bloating, and an electrolyte imbalance. Dosage depends whether it is an adult or child being treated.
This annoying problem is caused by the major doses of estrogen and progesterone your body produces early in pregnancy to relax smooth muscle tissue throughout your body —.
Morning Sickness. At the turn of the 20 th century medical doctors were still prescribing, of all things, strychnine for insomnia and morning sickness in pregnant mothers.
Smooth Move, by Traditional Medicinals, is a senna-based tea that relieves constipation within 6-12 hours after drinking it. The manufacturer states that the tea works by gently stimulating the intestine to produce a bowel movement.
Is it Acid Reflux or Indigestion? I remember 30 years ago we all used the word "indigestion" to refer to heartburn or stomach pain. With the advent of scientific research, we coined the phrase "acid reflux" and quickly people were using it interchangeably with "indigestion".
Yoga For Constipation Cure. Have you tried yoga for constipation cure? Constipation is most common digestive problems which is a by product of modern dietary habits and sedentary lifestyle.
Advice on self-care, symptom checkers, details of web and telephone services, leaflets and videos about what to do when you or someone you care for is ill.
Low Stomach Acid: A Surprising Cause of Indigestion Symptoms Low stomach acid is more to blame than too much stomach acid for the common indigestion symptoms associated with aging.


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TORONTO, ONTARIO--(Marketwire - Oct. 3, 2012) - Option Three Advisory Services Limited ("Option Three") announced that it subscribed for 9,666,666 units of BacTech Environmental Corporation ("BacTech" or the "Company"), (CNSX:BAC) for Cdn$1,450,000, or Cdn$0.15 per unit, by way of a private placement transaction as previously announced by BacTech on August 27, 2012, and intends to subscribe for an additional 333,334 units of BacTech for Cdn$50,000 as part of a second tranche of the previously announced private placement.
The units were issued by BacTech from treasury. Each unit consists of one common share and one non-transferable common share purchase warrant. Each warrant entitles Option Three to purchase one common share of BacTech at a price of Cdn$0.17 per common share for a period of 360 days from the first anniversary of the date of issue. The warrants can be exercised prior to the first anniversary of the date of issue provided that, after giving effect to the exercise, Option Three, nor any of its affiliates (as such term is defined in the Securities Act (Ontario), shall not directly or indirectly own more than 19.99% of the then issued and outstanding common shares of BacTech. The common shares and warrants are subject to a four month hold period.
After the issuance of 9,666,666 units of BacTech to Option Three, Option Three will own approximately 19.83% of BacTech's outstanding common shares, on an undiluted basis, and approximately 33.09% assuming only Option Three exercises its warrants. Prior to the subscription, Option Three owned no securities of BacTech.
As part of its subscription for units, Option Three and the Company also entered into an exclusivity agreement whereby, among other things, and subject to applicable law, Option Three will be entitled to nominate a member of the board of directors of BacTech for so long as Option Three directly or indirectly holds at least 10% of the issued and outstanding common shares of BacTech, and Option Three has been given exclusivity for five years with respect to the investment in future projects in certain Eastern European countries. As part of this agreement, Option Three has also agreed to not, at any time, hold more than 19.99% of the issued and outstanding common shares of BacTech without the prior approval of BacTech.
The units were acquired by Option Three for investment purposes. It will evaluate its investment in BacTech from time to time and may, based on such evaluation of market conditions and other circumstances, increase or decrease shareholdings in BacTech as circumstances require. Option Three could increase or decrease its investment in BacTech depending on market conditions or any other relevant factor.
About Option Three
Option Three Advisory Services Limited was incorporated under the laws of the United Kingdom. Option Three specializes in consulting in the field of investment in environmental, clean technology, green technology and biotechnology.
For further information and to obtain a copy of the early warning report filed under applicable Canadian securities laws in connection with the transactions hereunder, please see BacTech's profile on the SEDAR website www.sedar.com.
For more information about Option Three and its investments, please contact Elena Gerasimovskaya at 44 01424 775209.
Contact Information:


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Facts About The Sandra Spagnoli Lawsuit
Posted Thursday, July 11, 2019 - 7:06 pm
By Victoria Talbot
What really happened in the latest lawsuit against Beverly Hills Police Chief Sandra Spagnoli?
In the end, the results were decidedly mixed, but mixed in favor of the chief and the City of Beverly Hills.
Attorney Bradley Gage sought more than $23.5 million. His clients received a fraction (4.68 %) of that, including legal fees.
The jury awarded Lt. Renato Moreno, who claimed he was denied a promotion to captain – though he did not apply for the positions–$350,000 for non-monetary damages (pain and suffering, as he claimed he had diarrhea).
For full story see the print edition of The Beverly Hills Courier, or download the e-edition.


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Plans Overview
The base of operations for your budgets can be found in the 'manage' section of the Jirav app. Here, you can create your plans as well as define them by time, purpose and/or type.
Once you've imported your actuals you can use this area to maintain version control while collaborating with your team and running scenarios to your heart's delight.Iterating/Cloning
Your business will have budgets that are approved by the board, but you also might want to play with scenarios that include future funding, conservative vs. aggressive performance estimates and time-boxed run rates.
You can do variations on any plan in the system by cloning it (be patient, it takes a few moments), naming it, and changing your assumptions. You can also create a brand new plan based on a different revenue method completely (e.g. top-down vs. bottoms-up).
Plan of Record (POR)
If you'd like to freeze a plan in time, you'll make it your plan of record (POR). You'll perform this using the same hamburger icon where you perform the other plan creating actions.
Tip: Once you freeze a plan as a POR, it cannot be unfrozen so be mindful of which plan you're making a POR. You can clone a POR to make a version that's editable.


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- Welcome to resident involvement
- Resident involvement news and reports
- Open House newsletter
- Celebrating 100 years of council housing in Croydon
- Housing scrutiny
- Neighbourhood voice
- Panel meetings
- Local resident involvement
- Training for residents
- Ways to get involved
- Online engagement
- Tenant & leaseholder panel
If you have access to the internet, you can now watch Croydon Council's Tenant and Leaseholder Panel meetings live as they happen from the Town Hall.
Dates of forthcoming Tenant & Leaseholder Panel meetings:
12 February 2019
23 April 2019
2 July 2019
15 October 2019
Meetings start at 6.30pm and take place at the Council Chamber, Town Hall, Katharine Street, Croydon CR0 1NX, unless otherwise stated.
This borough-wide panel focuses on broader housing issues which affect all tenants and leaseholders, including rent levels, anti-social behaviour and repairs policies.
Applications to join the panel are welcome from Croydon council tenants and leaseholders. Please read the person specification and complete the self-assessment if you would like to be considered for this role.
TLP meet four times a year with councillors and service managers. This is an important role - by joining TLP you represent all the tenants and leaseholders in Croydon and have a say in the big decisions affecting your housing services.
Agendas and minutes for meetings can be found in the Council and Democracy section of the website.
Resident involvement team
Floor 3, Zone A
Bernard Weatherill House
8 Mint Walk
- TLP Constitution [131.7KB]
- TLP person spec [41.2KB]
- TLP self assessment [68.0KB]


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The Gypsy and the Scientist
There has always been this internal battle whether to explore & play or read a technical journal. Even as I pen this bio, the Gypsy needs to go get lost in the Pine Trees of Bastrop while the Scientist must study "soil composition". There must be some of that in most of us, I'm just putting it out there. At this juncture in our career it is happily a symbiosis as the Gypsy gets to goof around the Food and Wine Trails while the Scientist does the heavy lifting; all the research and then writes about it. And who'd of known there is plenty of science in the study of wine. So let's see how this dueling duo manages their life over the years.
If the Grapevine Gypsy conjures up images of whirling dervishes and a kaleidoscope of inky-purple elixir streaming from the glass into the cosmos, that's a lead into the Gypsy's adventurous youth. She traveled around the world tasting culinary delights from Europe to Asia Upon returning home, the scientist obtained a Bachelor of Science degree majoring in Clinical Dietetics at the University of Washington, with an internship at Harborview Medical School in Seattle. Experience gained managing several cafes and various types of foodservice operations in the Lutheran Hospital System led to a collaborative opening of a mid-sized polished-casual Bistro in San Antonio, Texas in 1988. They owned, operated and functioned as Sommelier for the award winning restaurant for 28 years. Upon selling the establishment the scientist obtained Certified Specialist of Wine credentials from the prestigious Society of Wine Educators and is currently Sommelier at Bryan's on 290 located on the wine trails of the Texas Hill Country and is a Free Lance Writer of all things food & wine. And the Gypsy, well……..you know (wine trails).
Regarding this blog, posts will be written at all levels for the occasional quaffer to the serious wine student. Wine Science related topics will be housed in the Wine Science tab. Please keep in touch and let me know any topics you would like explored.
Barbara Hunt
a.k.a. the Scientist & Grapevine Gypsy
Sommelier, CSW, BS


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Hans Ulrich Obrist
Artistic director of the Serpentine Galleries and instigator of global, networked art projects
'The work of the Serpentine – and its incomparable artistic director – cannot be allowed to be undermined,' wrote CEO Yana Peel on quitting the London institution following revelations of her links to a cyberweapons company. Peel's resignation was swift, allowing Obrist to concentrate on what he does best: being everywhere, knowing everyone. Outside the Serpentine Galleries – including shows for Pierre Huyghe, Emma Kunz, Hito Steyerl and Faith Ringgold this past year – and keeping a hand in the Luma Foundation in Arles, Obrist is also artistic adviser to The Shed, the New York arts complex that opened in April. That institution is directed by Alex Poots, his old chum from the Manchester International Festival, to which Obrist returned this year to cocurate an 'exhibition of literature' with novelist Adam Thirlwell. Not content with shaping art, Obrist also was art: the subject of 50 Times Obrist, a suite of paintings by Francesco Bonami. With this workload, Obrist really does need cloning.


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New Meme Emerging for Climate Change
The prevailing wisdom has been that there's very little we can actually do about climate change. Even environmentalists are prone to admit, after strenuously arguing the opposite, that there is little hope given the amount of money controlled by the fossil fuel industry. As the International Forum on Globalization observed in Outing the Oligarchy, "Cooperative global action to address the most daunting challenge humanity has ever faced is being held hostage by a handful of profiteers who wield decisive power over our governments."
The Koch Brothers, oil and coal profiteers and founders of Koch Industries, a fossil …read more
Source: Huffington Post Green


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A Perfect Family Holiday » Suites in ZillertalModern amenities in combination with rustic Tyroleam charm make up the atmosphere in the rooms and suites in Zillertal for a special and stylish feeling of well-being.
All of our rooms are in the main building of the alpina zillertal, the suites are in the second building. There is free WLAN in the entire hotel.
All of our suites are furnished with wooden flooring.
Healthier rest in the alpina zillertal: Our beds for your wellbeing.
Falling into a comfortable bed, tired and happy after an exciting day - doesn't that sound wonderful? When you spend your family holiday at the alpina zillertal we don't just want you to get some sound sleep - but rather the best sleep ever! That's why our rooms and suites are furnished with box-spring beds with special pocket-spring mattresses and cold-foam topper. Our bed linens are suitable for guests with allergies.
Children's Prices
Small guests benefit from small prices. Nevertheless our service is broad:
in Summer and Winter MO till SU 9am - 9pm
supervised children's meal at lunch and dinner, baby equipment on loan ...
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0-1 years
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|0-1 years
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|2-5 years
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Look forward to a family holiday in our hotel with childcare in Austria!


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Sporadic shooting rattled around a refugee camp in Lebanon yesterday after a night of gunbattles as the army battled to wipe out an al-Qaeda-inspired militia holed up inside.
Fighting was continuing on the 18th day of a deadly standoff between troops and the Sunni extremist group Fatah al-Islam, amid reports the resolve of the besieged militants was weakening and some were surrendering.
"The terrorists fired off a volley of shots from light weapons towards army positions on Wednesday [yesterday]," an army spokesman said.
"The shooting followed a night of army bombardments against positions of Fatah al-Islam, which opened fire with heavy weapons against our soldiers encircling the camp," he said.
The clashes erupted on May 20 around Nahr al-Bared and the nearby Mediterranean port city of Tripoli, rapidly deteriorating into the deadliest internal fighting Lebanon has seen since the 1975 to 1990 civil war.
Security has also been shaken by a series of bomb blasts in and around Beirut and police yesterday said a bomb was defused on a road leading to popular beaches in the southern port city of Tyre, a stronghold of Shiite militant groups in Lebanon.
Three Sunni militiamen hiding inside the Nahr al-Bared camp gave themselves up on Tuesday, with more seeking guarantees of safety if they do, the mainstream Palestinian faction Fatah said.
"Fatah al-Islam is in terminal phase, as its members are deserting its ranks," Fatah's leader in Lebanon Sultan Abu al-Aynayn said.
He said three gunmen had surrendered and handed over their weapons and that 18 others said they had stopped fighting and were seeking guarantees to turn themselves in, leaving only about 75 militiamen still fighting.
There was no confirmation from the Islamist group, which has vowed to fight "until the last drop of blood."
"We have information that there were some elements which gave themselves up, but the army has not received any of them," an army spokesman said. "We have information that some elements have also dropped their arms and left the fight, as many of them are in poor spirits.
"Now the army is continuing to tighten the noose on the gunmen, respond to the source of fire, track down armed elements and clear areas where there are explosives," he said.
During a lull in fighting on Tuesday, a convoy of ambulances and trucks loaded with medicine entered the squalid camp to supply the refugees still remaining amid fears of a humanitarian crisis.
In all, 108 people have been killed in 18 days of the unrest that has served to exacerbate a tensions in a deeply divided country already in the grip of an acute political crisis.
Lebanese Prime Minister Fuad Siniora has warned Fatah al-Islam to surrender or be wiped out.
Meanwhile, Fatah al-Islam military commander Shahin Shahin threatened to take the fight to other parts of Lebanon and beyond if the Lebanese army did not stop attacking a Palestinian refugee camp.
"If the army continues to bomb civilians and pursue its inhumane practices ... we will move within the next two days to the second phase of the battle," Shahin said during a telephone interview yesterday.
"We will show them the capabilities of Fatah al-Islam, starting with Lebanon and then moving to the whole of Greater Syria," he said, using a term intended to include what is now Lebanon, Syria, Jordan, Israel and the Palestinian territories.


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Actually, this is a follow up post from my performance deep dive into tablespace encryption. After having investigated how tablespace encryption works, this blogpost is looking at the other encryption option, column encryption. A conclusion that can be shared upfront is that despite they basically perform the same function, the implementation and performance consequences are quite different.
Thanks to suggestions made by Frits Hoogland, I made some improvements to the ODBV. The new version can be found here: http://ora-600.pl/oinstall/odbv.x86_64
The changes are:
The blocks will be coloured properly to belonging segment.
Thanks to suggestions made by Frits Hoogland, I made some improvements to the ODBV. The new version can be found here: http://ora-600.pl/oinstall/odbv.x86_64
The changes are:
The blocks will be coloured properly to belonging segment.
When sifting through a sql_trace file from Oracle version 12.2, I noticed a new wait event: 'PGA memory operation':
WAIT #0x7ff225353470: nam='PGA memory operation' ela= 16 p1=131072 p2=0 p3=0 obj#=484 tim=15648003957
The current documentation has no description for it. Let's see what V$EVENT_NAME says:
SQL> select event#, name, parameter1, parameter2, parameter3, wait_class 2 from v$event_name where name = 'PGA memory operation'; EVENT# NAME PARAMETER1 PARAMETER2 PARAMETER3 WAIT_CLASS ------ ------------------------------------- ---------- ---------- ---------- --------------- 524 PGA memory operation Other
Well, that doesn't help…
It's time for the next article with ODBV visualisation
It's time for the next article with ODBV visualisation
From time to time I get questions on my trainings, what is the difference between TRUNCATE TABLE and TRUNCATE TABLE DROP STORAGE… well, there is no difference because DROP STORAGE is default
In my previous post, I introduced Intel Pin. If you are new to pin, please follow this link to my previous post on how to set it up and how to run it.
One of the things you can do with Pin, is profile memory access. Profiling memory access using the pin tool 'pinatrace' is done in the following way:
$ cd ~/pin/pin-3.0-76991-gcc-linux $ ./pin -pid 12284 -t source/tools/SimpleExamples/obj-intel64/pinatrace.so
The pid is a pid of an oracle database foreground process. Now execute something in the session you attached pin to and you find the 'pinatrace' output in $ORACLE_HOME/dbs:
This blogpost is an introduction to Intel's Pin dynamic instrumentation framework. Pin and the pintools were brought to my attention by Mahmoud Hatem in his blogpost Tracing Memory access of an oracle process: Intel PinTools. The Pin framework provides an API that abstracts instruction-set specifics (on the CPU layer). Because this is a dynamic binary instrumentation tool, it requires no recompiling of source code. This means we can use it with programs like the Oracle database executable.
The Pin framework download comes with a set of pre-created tools called 'Pintools'. Some of these tools are really useful for Oracle investigation and research.
For those in a desperate need to learn all 4841 database parameter variations of the…


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The Sartorial Edge, Six-Pair Gift
Product details
Give a gentleman the sartorial edge, with six style-forward socks for the sharp dresser. Three classic fine stripe styles from our Grosvenor collection combined with three popular designs from our Simply Sartorial range in our iconic block rib style.
Featuring: Grosvenor Fine Stripe Red, Grosvenor Fine Stripe Blue, Grosvenor Fine Stripe Grey, Simply Sartorial Routemaster Red, Simply Sartorial Midnight Blue, Simply Sartorial Cannon Ball Grey.
- Size & FitEach pair is finely knitted using our unique Scottish Lisle Cotton blend, stretch-fit for extra comfort, designed to sit perfectly mid-calf, and available in sizes S, M and L.
Shoe size UK US EU Small 4 – 7.5 5 – 8.5 37 – 41 Medium 8 – 10.5 9 – 11.5 42 – 44 Large 11 – 13.5 12 – 14.5 45 – 48
- Delivery & ReturnsOrders placed by 2pm on any business day, will be dispatched the same day, but shipping times will vary. Click here for typical shipping times.
We offer a one year Sock Sure quality guarantee, and gladly accept returns up to 28 days after your order has been placed.
- Composition & CareWe use super soft, silky smooth Scottish Lisle Cotton yarns, blended with clever man-made fibres for stretch-fit, so each pair of socks combines comfort, colour and durability. Like many top quality men's dress socks, you'll notice that our Simply Sartorial range feels wonderfully lightweight and soft thanks to the unique fine knit of the Scottish Lisle Cotton. It means that they'll stay put but you'll barely notice they are there – but others most certainly will.
Wash inside out, at 30°C, with similar colours, to maximise wear and durability. And no tumble drying, dry cleaning, ironing or bleaching, please. After washing they may appear narrower but fear not, they'll return to the same comfortable size and fit as soon as you put them on.
- Size & Fit


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Stone Age
Stone Age
Stone Age is an interesting card matching memory game, if you think you have a good memory, come here and have a try. Your aim in this game is match the blocks and clear the levels. The less moves you do the more stars you get. Have a good time!
Add This Game To Your Site (RSS)
Free Mobile and Tablet Games - M.SHTOSS.COM © 2018


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From Geeky Thick Frames To Minimalistic Chic
November 13, 2018
If you've been donning thick eyeglasses for the last couple of years,it's time to refresh your look with 2018's 70s-inspired metal frames. Choose thin metal-framed round glasses to a slightly larger aviator style frame. This eyewear trend is the perfect look for the playful minimalist that likes to have fun with their style.
Laurie comes in ROSE/SILVER C1 - BLACK/GOLD C2 - NAVY BLUE/COOPER C3
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Why by-elections don't matter
October 13, 2014
Whitehouse Consultant Sam Blainey analyses the importance -or lack thereof- of the recent by-elections.
To read Sam's article, please click here.
The Whitehouse Consultancy is one of Europe's leading public affairs and communications agencies.chriswhitehouse
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Our Top Mental Health Articles for 2019
In this the second of our two final articles for 2019, we provide a summary of our top mental health
In this the second of our two final articles for 2019, we provide a summary of our top mental health
Several countries around the world, including Australia, are in an economic downturn that is causing financial stress. In Australia, one-third
With 24/7 connectivity and the ability to work at any time detaching from work can be difficult. Our mental health
It's Mental Health Week and today is World Mental Health Day. We regularly write articles on managing employee mental health,
What are some of the typical factors that increase depression symptoms? Well, we're all working hard trying to get the
Organisations that are keen to support employee well-being are often searching for the next mental health theme to keep the
With psychological injury on the rise, mental health and worker well-being are fast-moving onto the radar in terms of business
It's been a few years since the WA Standing Committee completed the review on mental health and FIFO work arrangements.


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I want to engage Canadians, and need your help to ensure we are heard in the House of Commons. By taking advantage of an Member of Parliament's privilege to table petitions on issues that Canadians care about. I can table a petition or two every single day that Parliament is in session, which is roughly 140 to 280 petitions a year!
A petition is a formal request to an authority for redress of a grievance. Public petitions, addressed to the House of Commons and presented to the House by its Members, constitute one of the most direct means of communication between the people and Parliament. Petitions today may be described as a vehicle for political input, a way of attempting to influence policy-making and legislation and also, judging by their continued popularity, a valued means of bringing public concerns to the attention of Parliament. Petitions also have their place among the tools which Members and Ministers can use to formulate public policy and to carry out their representative duties.
Paper Petitions
To sign or create
an e-petition
click here
To sign or create
a paper petition
click here
An Oilsands Bargain that Actually Makes Sense
May 29th, 2019
The SNC-Lavalin cloud over the 2019 budget
March 23rd, 2019
We are having the wrong conversation, we are in a climate emergency
March 13th, 2019
Election 2019, the Green Party: Climate Change is the Issue
January 7th, 2019
Report from COP24 in Poland
December 12th, 2018
Natural Resources Canada has evolved into the Department of Oil and Gas
December 12th, 2018
Mixed reactions from Greens on new cabinet
November 20th, 2019
Elizabeth May steps down as Green Party Leader
November 5th, 2019
Trudeau's ethics breach demonstrates need to get corporate influence out of government
August 16th, 2019
Elizabeth May only federal leader to accept invitation to Assembly of First Nations General Assembly
July 24th, 2019
An opportunity to choose a no-carbon solution squandered, says Elizabeth May
July 19th, 2019
When hard working Canadians can't afford to live in their hometowns, that's not good enough
July 19th, 2019
Letter from Elizabeth May to Prime Minister Trudeau
October 24th, 2019
Trudeau's ethics breach demonstrates need to get corporate influence out of government
August 16th, 2019
Week in Review: June 17 – 21
June 26th, 2019
Elizabeth May joins colleagues in honouring the late Mark Warawa, MP for Langley-Aldergrove
June 20th, 2019
Elizabeth May vous souhaite une bonne Saint-Jean!
June 20th, 2019
Constituency Office
1-9711 Fourth St
Sidney, BC V8L 2Y8
Phone: 250-657-2000
Fax: 250-657-2004
E-mail: firstname.lastname@example.com
Parliament Hill Office
518 Confederation Building
House of Commons
Ottawa, ON K1A 0A6
Phone: 613-996-1119
Fax: 613-996-0850
E-mail: firstname.lastname@example.com
Jobs & Volunteering
Click here for the latest opportunities


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Natures Answer Af Nettle Leaf
1 fl ozUPC: 0008300000650
Purchase Options
Urtica dioica, more commonly known as stinging nettle, nettle, or nettle leaf is a plant that has been used for its healthy benefits for hundreds of years, dating back all the way to Ancient Greece. Commonly used in traditional herbal practice, as well as in nettle teas, the roots as well as the leaves, provide health benefits. Nature's Answer takes the Stinging Nettle and brings you a super concentrated 2,000 mg extract providing all the benefits of the Nettle Leaf. It supports prostrate health, and helps maintain the health of the urinary tract.* Important health benefits that herbalists have been taking advantage of for years.
- Herbal Supplement
- Helps Support Prostate Health
- Urtica dioica
- Gluten Free
- Alcohol Free
- Kosher


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See All Construction Equipment For Sale near you By Moore's Service Center . Rock shredder- Stone Crusher- Soil Stabilizer and Asphalt shredder for tractors between 80 & 190 HP Working depth 11 inches, working width 59 inches. . 12" Rock Crushing Diameter, Requires tractor 80-220 Hp Shown with M126X Tractor w/ LA2253 Loader, 126 Hp .
Visit one of our 11 Warren Rental Store locations, contact us online or call us at 866-292-7736 for a free quote on a rock crusher rental. Powerful and Dependable Rock and Concrete Crushers for Rent. We maintain a wide variety of rental aggregate equipment models to ensure you have the support you need to remain productive.
MIDIPIERRE - SEPPI stone crusher crushes stones up to 20 cm [8"] Ø. The little stone crusher MIDIPIERRE clears land from stones, no matter whether for agricultural land, as a step of land reclamation, for the maintenance of ski slopes, or for land clearing and construction site preparation.
Find Fae Rock Crusher for sale on Australia's No1 online machinery market. Currently there are Fae Rock Crusher dealer or private sales. Browse further to find more Fae Rock Crusher . 14 Jun,2019 - The tractor is a must-have workhorse for just about anyone in the agricultural industry, but how do you decide whether a 2WD or 4WD tractor is .
May 04, 2013 · tractor driven rock crusher. mini jaw crusher for sale . Rock crusher comprising a rotor on which hammers are . which has just been described, the rotor 4 is . stone crusher powered by tractor pto manufacturer in
A Crusher is a device for reducing the size of material by the action of allping a force to it to "Crush" it. These machines come in a variety of sizes and types. The most common use is for producing small sized stone for use in construction, but a growing market is the breaking up of old.
Visit one of our 11 Warren Rental Store locations, contact us online or call us at 866-292-7736 for a free quote on a rock crusher rental. Powerful and Dependable Rock and Concrete Crushers for Rent. We maintain a wide variety of rental aggregate equipment models to ensure you have the support you need to remain productive.
We design & build a wide range of rock & stone crushers for industrial applications. Whether you are looking to reduce rock to gravel, coarse sand, or even a fine powder we have the machine for you. Browse our rock crushing machines today & find one perfect for your project.
The Midisoil DT is a two speed gear drive stone crusher/forestry mulcher capable of working to a depth of 25cm, . rock and concrete. . * technical requirements for operating a stone crusher on a tractor are creep speeds and a hydraulic three-point tractor linkage .
"My home-built rock crusher lets me get rid of rocks right in the field. I never have to handle them again," says Ivan Trantham, Millerton, Penn., who mounted rock quarry crushers on an old truck frame. He uses an 84 hp Ford 7600 tractor to pull the pto-driven rig across plowed fields before he plants.
The Rock Crushers are a three point linkage tractor mounted unit that can crush material up to 400mm in diameter at a rate of 300 plus tonne per hour. The tractor can travel at speeds up to 50km per hour on the road, making travel between jobs cost efficient.
Rock Crushing Equipment and Iron Ore Crushing Machines for Sale Savona Equipment is a hard rock crushing equipment supplier worldwide. Mining operations use crushers of all types for various applications, with primary and secondary crushers handling coarse materials, and tertiary and quaternary crushers reducing ore particles to finer gradations.
May 29, 2013 · Crushing equipments mainly include jaw crusher, cone crusher, impact crusher, mobile crusher according to its working principle. portable stone crusher driven by pto of tractor Heavy construction equipment refers to heavy-duty vehicles, specially designed for executing construction tasks.
australia pulverizer stone crushers · tamiya terra crusher truck for sale · stonegranding machine china · mobile rock crushing tractors · ball mill price in south. Get Price. Rock Machinery Venom 24 Tractor Mounted PTO Stump Grinder . The Rock Venom 24 PTO Stump Grinder. Rock Machinery''s first PTO drivenstump grinder.
Crushers Crushers are an important part of many industrial and materials processing projects. They allow for the crushing of rocks into gravel, smaller rocks, or even miniscule dust. Equipment Trader's website allows users to quickly search for the best models near to their zip code from the brands and dealers that they have come to trust.
Fae Usa – PTO/Tractor Rock Crushers – PTO/Tractor Rock Crushers . slopes, or any type of application where stone crushing . Powered by Xtend new media Vat . rock crusher powered by tractor – the best selling mobile .
Tractor mounted Crushers - Reliable, Efficient and Cost Effective road equipment for professionals. Superior design and engineering enables MeriRoad crushers to work effectively above and below the ground level. Typical, and ideal uses Crushing the ground before stabilizing, Preparing the subsoil for laying sett (car parks, roads, residential .
Portable rock crusher - great for sampling gold bearing and other rocks in the field! Portable -- weighs only about 10 pounds. 1 year manufacturer's warranty. Grinding chamber: 7.5 inches x 3.5" wide x 9" tall including feed tube. This latest model of the Cobra Crusher has a straight feed tube.
Crushers for Sale Buy and sell unused and used Crushers at IronPlanet. Whether looking for a Cone Crusher, Impact Crusher, Jaw Crusher or other various type, IronPlanet offers several makes and models that can help efficiently and effectively complete your task. Browse popular models from top manufacturers including Cedarapids Crushers, Crushers and others.
Sep 19, 2012 · 24x15 PTO Tractor Driven Crusher Sept 2012 Part B.
"My home-built rock crusher lets me get rid of rocks right in the field. I never have to handle them again," says Ivan Trantham, Millerton, Penn., who mounted rock quarry crushers on an old truck frame. He uses an 84 hp Ford 7600 tractor to pull the pto-driven rig across plowed fields before he plants.
Rock Crushing: Being a Texas company and knowing how hard it is to clear land in the Texas Hill Country, do to the rocky terrain, we have found the right machine for the job. In 2000, Bushwacker Tractor Service, Inc. began a new service for the State of Texas, free floating rock crushing.
Nov 08, 2013 · FAE - HEAVY DUTY ROCK CRUSHER STCH/R 225 -PTO TRACTOR MOUNTED ROCK CRUSHER.
rock crusher powered by tractor – the best selling mobile . , the world leader in rock and minerals processing, has also pioneered the development of track-mounted, fully mobile crushing plants.
Alibaba offers 194 tractor rock crusher products. About 36% of these are crusher, 1% are mine mill. A wide variety of tractor rock crusher options are available to you, such as impact crusher, jaw crusher, and cone crusher.
Jan 17, 2005 · The typical cone rock crusher that will take 24" -30" rock is about 1000 hp. Even then operators don't wan to feed all large pieces like that. All rock that is larger than capacity has to be reduced to size by either a hammer or blasting. In order to get a machine on site around here you typically need a minimum of 10,000 yards to crush.
The average miner can instead purchase a CrazyCrusher manual rock crusher or an electric or gas powered rock crusher and get the gold out in smaller batches. Crushing rock to recover gold can be easier, faster, and much more profitable than prospecting in over-worked streams and rivers.
Browse our inventory of new and used Crusher Aggregate Equipment For Sale near you at MachineryTrader. Top manufacturers include KINGLINK,, POWERSCREEN, CEDARAPIDS, , WHITE LAI, , KPI .
Search 37 listings of Used Stone crushers For Sale by private parties and dealers. Find the best deal on Agriaffaires US. Your experience on our website is our priority. We therefore use cookies, as we legitimately have our hearts set on improving user experience, producing statistics and offering ad inserts based on your areas of interest .
The rock crusher components weigh 12,000 lbs. Total weight is 16,000 lbs. so my 84 hp, 2WD tractor has all it can handle on plowed fields. I pulled the gears out of the truck axle to make it lighter and welded a steel plate over the opening where the gears had been, then filled it with oil to lubricate the axles."


text: Quality Matters! There are various grades of "essential oils" in all types of products from cosmetic to therapeutic. But not all essential oils are equal. To experience the potential benefits of pure essential oils, look for 'therapeutic grade' (although this is not a term that is regulated by the powers that be, it is an indicator of purity.) oils and research the manufacturer to ensure they follow Good Manufacturing Practices (GMP) to bring you the highest quality product. Poor quality oils or those those that have been adulterated are becoming more prevalent as the popularity of essential grows.Unfortunately, there have been a growing number of people turning up with chemical burns, allergic reactions, respiratory issues, and other side effects from poor quality aromatic plant extracts. So be aware and look for these basic quality markers:


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IT guy • Triathlete • Avid traveller • Net addict
Our mission is to be the best way to get started with your next web app. We believe devs spend way too much time wrestling with technical choices and rebuilding the same basic layouts. Divjoy lets you skip all that so you can spend more time focused on what makes your web app unique.
Looks like a nice launchpad for my React adventures.Link
But the split that worries the most is this: The people who make the web vs. the people who are excluded from making the web.
Excellent article by Jeremy Keith! #web #developmentLink
Stop editing your etc/hosts file with custom hostname and IP address mappings. nip.io allows you to do that by mapping any IP Address to a hostname.
This is really handy. #development #webLink
ngrok allows you to expose a web server running on your local machine to the internet. Just tell ngrok what port your web server is listening on.
This looks quite helpful for web development. Found in the @bitsundso picks. #web #developmentLink
Tenon.io can identify 508 and WCAG 2.0 issues in any environment - even on your developer's laptop. Because production is a bad place to discover bugs.
Check your website for accessibility issues. #a11y #web #developmentLink
The online IDE for web applications. Powered by VS Code.
#development #javascript #web2.0Link
Case studies and experiments demonstrating the impact of web performance optimization (WPO) on user experience and business metrics.
If you have to tell your manager why you want to optimize the speed of your site. #web #development #managementLink
Easily generate the optimal responsive image dimensions. One image for all screen resolutions and different devices is not enough. An image per pixel is too much - so how can someone automatically choose the optimal responsive image sizes?
Build better web sites - lint the web forward.
Marcy Suttons talk from beyond tellerrand Munich 2017. #btconf #a11y #web #developmentLink
Charles is an HTTP proxy / HTTP monitor / Reverse Proxy that enables a developer to view all of the HTTP and SSL / HTTPS traffic between their machine and the Internet. This includes requests, responses and the HTTP headers (which contain the cookies and caching information).
With more and more emerging markets coming online, and more and more apps moving to the web platform, we're reaching an intersection where connections are getting slower and websites are getting heavier. In this talk, we'll learn just what these emerging markets mean to us, and how we can begin to move in the right direction.
Chrome Canary's developer tools have an experiment where you can debug color contrast right in the style inspector.
Submit a URL to generate a node map of all of the requests on the page. Rapidly identify what third-parties are on your site, where your transmitted bytes are coming from and how slow your domains are!
This tool allows WYSIWYG editing of impress.js presentations.
Alpha version, though. A bit rough around the edges. #presentation #javascript #webLink


text: Cadwell Park celebrates its 85 th anniversary in 2019 and what better way to celebrate than by hosting Round 8 of the Bennetts British Superbike Championship? A real favourite with the fans, the 'Mountain' section regularly produces some of the most stunning images of the season, with both man and machine flying through the air! We can't wait to see you all at the 'Party in the Park'!


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Micheal Smith | Healthwatch Manager
Micheal moved to Leicester from Lancashire to study at De Montfort University in 1995. After working in the banking sector for 10 years as a Complaints Manager, Micheal began working in outreach and public engagement when he joined the Local... more
Gillian Jillett | Community Outreach Lead – City
Gillian has 8 years' experience with Healthwatch Leicester and Healthwatch Leicestershire as an Adviser and Executive Assistant. Gillian also worked for 11 years at E.ON UK as Customer Service Advisor, Lead representative and negotiator for Unison in E.ON and also... more
Bryonie Mellor | Community Outreach Lead
Bryonie moved to Leicestershire in 2016, having lived in Scotland for twenty-five years. Before graduating from the University of Dundee with a degree in Social Work in 2014, she had worked for Perth & Kinross Council's Drug & Alcohol Team,... more
Nazmin Pirbhai | Community Outreach Lead
After graduating from De Montfort University with a degree in Health Studies in 2015, Nazmin has worked in various NHS organisations. Nazmin has worked in various teams including, the Children's Immunisations Team, Adult Mental Health Team and Brokerage.
More... more
More... more
Gemma Barrow | Community Outreach Lead – County
Gemma has over 8 years' experience working in local Healthwatch and the Local Involvement Network (LINks). Gemma has extensive knowledge working in partnership with statutory, voluntary and community sector organisations and has established close relationships with Health & Social Care... more
Paul Blakey | Deputy Manager
Paul recently (3 October) joined Healthwatch Leicester and Leicestershire as the Deputy Manager, reporting to Michael Smith. In this role, Paul will use the 25+ years experience he has of working within the health and social care sector throughout England.... more
Harsha Kotecha - Chair
I am delighted to introduce the first four members of the Healthwatch Advisory Board for Leicester and Leicestershire – Shireen Bharuchi; Mark Farmer; Colin Norman and Rita Patel.
The... more
The... more
Mark Farmer
Mark has lived all over Leicestershire and Leicester, bringing insight into urban and rural health challenges. With a varied professional life across the public and voluntary sector, Mark has a... more
Rita Patel
Rita has lived in Leicester and Leicestershire for 35 years and worked as an NHS Occupational therapist for 15 years.
"Currently I am Vice Chair of Leicester Research Ethics... more
"Currently I am Vice Chair of Leicester Research Ethics... more
Shireen Bharuchi
Shireen was born and grew up in Leicester before embarking upon a career in healthcare: I have always empathised with patients, whilst understanding the important role the public can play... more


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By Mauricio Sulaimán – President of WBC / Son of José Sulaimán: The ancient city of Tokyo, in Japan, is getting ready to receive and greet the entire world, to celebrate the most important global sporting event, the Olympic Games, which will be held in July and August of this year. » Read More
Avni Yildirim is requesting The WBC to order an immediate rematch against Dirrell
Avni Yildirim from Turkey arrived in Mexico City with his promoter Ahmet Oener to meet WBC President, Mauricio Sulaiman.. » Read More
Mauricio Sulaiman / 5th Anniversary as World Boxing Council President
Five years have passed since Mauricio Sulaiman Saldivar, in an extraordinary meeting held in Mexico City, was elected President of the World Boxing Council, following the passing of his beloved Father Don José Sulaimán, who led the WBC for 38 years. » Read More
WBC president Mauricio Sulaiman back from Arizona
Mauricio Sulaiman, from Mexico, President of the World Boxing Council, just returned from a very successful trip to Arizona. » Read More
Sulaiman: Wilder vs. Joshua needs to take place
WBC president Mauricio Sulaiman wants to see the unification fight between WBC heavyweight champion Deontay "Bronze Bomber" Wilder and IBF/WBA champion Anthony Joshua. » Read More
WBC president Mauricio Sulaiman talks boxing
By Mauricio Sulaiman
WBC President – Jose Sulaiman´s son – The Jose Sulaiman Champion´s Fund
My father, Jose Sulaiman, a son of an immigrant Lebanese father and an immigrant Syrian mother, grew up in Ciudad Valles, a small town in San Luis Potosi State in Mexico. » Read More


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It was a busy but fantastic week for TrustArc in the Belgian capital at the annual International Association of Privacy Professionals Europe Data Protection Congress. TrustArc began the conference with the announcement of its acquisition of privacy industry heavyweight Nymity. The companies have joined forces to accelerate development of the next generation of technology-driven privacy solutions. The news was received with overwhelming excitement by conference goers and news media, and will usher in incredible new content and product synergies for current and future customers. In addition to countless conversations with friends old and new from organizations of all sizes, industries … Continue reading TrustArc + Nymity Take Center Stage at IAPP Europe Data Protection Congress in Brussels
TrustArc + Nymity Take Center Stage at IAPP Europe Data Protection Congress in Brussels
November 25, 2019


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In your own words, please say what the beekeeper said.Continue Reading
Have you thought that it is possible to have a beehivee on the top of a skyscaper? Do you have any idea what IOT is? Have you ever seen a bee in city?Continue Reading
Startups Addressing the Problem ___ ApisProtect is addressing the problem with their vision to preserve ⅓ of the world's food supply through hive monitoring technology. They just raised $1.8 million for bee-monitoring sensors that enable beekeepers to prevent losses while tracking both honey and pollination productivity. ApisProtect was started by Fiona Edwards, who was studying […]Continue Reading


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Nichole Krieger
I'm at it AGAIN!!!! Going Over the Edge on September 25, 2019 to support kids in our racing communities.
Give me that extra "push" I need to reach my goal - - PLEASE DONATE TODAY - - to my campaign.
Help me to "Be a HERO for Kids!" and I promise I won't "chicken out!"
About the charities I support...
The NASCAR Foundation is a leading charity that works to improve the lives of the children who need it the most in our NASCAR Communities. We believe every child should have a chance at a healthy life and deserves to get across the finish line. The NASCAR Foundation is making children's health and medical needs our top priority. Through the Speediatrics Children's Fund, an Initiative of The NASCAR Foundation, we provide much needed health care and assistance to children who need it most so they are able to go full speed ahead in leading happier, healthier lives.
The NASCAR Hall of Fame Foundation works to ensure pre-K - 12 students have a competitive edge through education that best equips them for life and drives their future success. NASCAR Hall of Fame Foundation leverages their unique assets within the motorsports industry to provide economically disadvantaged students with engaging and interactive learning opportunities that meet state and national curricula criteria and are based in career pathway STE(A)M skills. Such experiences align with the community's focus to strengthen its academic offerings to children who may not be able to receive them without the support of organizations like the NASCAR Hall of Fame Foundation.