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Rachel Green a fictional character from six cast members of friends which started on September 22, 1994, and completed 236 episodes on May 6, 2004. Rachel Green has influenced this web series a lot as during this series she became youth icon as well as wonder actress. The Actual name of Rachel Green is Jennifer Aniston. She turned 49 this February 11. So there are some of best Rachel Green's outfit.
In the pilot episode of friends as well as it was her grand entrance Rachel Green wore off shoulder wedding dress with a beautiful veil which gives her a glamorous and beautiful look she wore it as she flew away from her wedding and there on the coffee shop she, fortunately, found her best friend Monika Geller.
Also, get to know all about the best Outfits of Monica Geller from F.R.I.E.N.D.S.
In the fourth episode of, season one Rachel green wore an all-black dress with plain button-up black crop shirt with high waist mini skirt which was looking appropriately pretty and giving handsome look to Rachel green.
In episode ten of the season, 2 Jennifer Aniston used leopard print top having tortoise neck with beautiful black jeans and with it she tied her hairs up and then she used lovely earrings with the whole combination she looks pleasant and gorgeous in the complete dress.
COLOURFULL STRIPPED BLAZER: one of Best of Rachel Green's outfit.
In second season episode, 18 where Dr Remory dies Rachel green wore a colourfull blazer to pay her fun tribute to a doctor.
She used colorful blazer with a plain white shirt and classic blue jeans which proves she is not afraid to rock a pattern.
Thus, it is one of the best of Rachel Green's outfit.
Black and white are the favorite colors of approximately every girl so Rachel green also rocks in this combination where she used black miniskirt with geometrical black and white skin tight top which ultimately make her look stunning, charming, and delightful.
In season three, episode number seven Rachel Green wore Brown Suede West which was one of the dresses which she wears when she is on her duty working in Central Perk which includes button-up Shirt.
It was one of the most memorable looks of her in the whole session of friends.
In season 4, episode 18 she wore this dress when she was to meet her crush at her work when she works at Ralph Lauran. This dress has long sleeves and it is a semi-sheered black dress, the flowers on it give it much more fantastic and glamorous look.
She straightened her hair and kept them free which of-course would give her much more stunning and hot look.
In episode 18 of season, 7 Rachel green wore Red gown when she was going with Joey in his award ceremony. This Red colour gown had a form-fitting silhouette which gives a plus point to Rachel green's magnificent and decorative look.
The floral printed skirt which was a backless and patterned halter dress with a cut and also has a deep neck.
She used this dress in season 9, 14th episode.
This is the best dress which anyone should wear if she is going to the beach or in a warmer area to enjoy the holidays.
Estelle named character was joey's agent. Rachel Green wore this wonderful dress when joey was sad about MRS. Estelle death in episode 15, season 10. Turtle neck t-shirt with a pleated miniskirt and 'using high neck shoes with it gives her absolutely preppy look and it was one of the distinct pieces of her dresses in the whole web series.
In season 8, episode 6 Monika throws Halloween party to all her friends. In that party, Rachel Green wore dress fully embroidered and strapless. This dress was giving a graceful and elegant look to Rachel Green and with this dress, Rachel used a few accessories including black choker but, still, she was looking stunning.
Last season, last episode and the most emotional episode was the most remarkable episode among all.
Black and white combination in dresses in the best combination for every person and Rachel Green used it in the last episode. She expertly assembled black tank top over a white T-Shirt and she also reused her high neck boots with this dress and overall she looks alluring, winsome, and divine.
Rachel Green outfits are most amazing and most adorable outfits which every girl should use to look magnificent and attractive like Rachel Green.
So, every girl in her whole life should at least try one outfit from Rachel Green's outfit and I am sure that she will look amazing and attractive.


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All cosmetic problem areas can be treated without pain and free of side effects with oxygen skin care treatment and Nora Bode's leading OXYJET Oxy Facial Kit Machine. Dependent on the selected special preparation, wrinkles are filled up, pigmentation spots are lightened or blemishes are gently softened and removed. The so formed deposit of active ingredients deep in the skin unfolds its positive effects over a long time. At the same time the oxygen provides the skin with new energy and freshness. They're just some of the benefits of oxygen jet facial treatments!
With the oxy facial kit machine, the penetration of the special preparations takes place in a natural way: The pulsed oxygen jet facial pressure transports the active ingredients deep into the skin using the natural interstices between the cells. The skin is not hurt during this process.
Nora Bode's Oxyjet oxy facial kit machine shoots active ingredients that are applied deep into the skin by using different degrees of pressure. Oxygen skin care treatment penetrates deep into the skin and forms a deposit there, without the need for syringes and needles.
If you would like to find out some more information about Nora Bode's Oxyjet oxy facial kit machine, or to get in touch about any questions you may have regarding oxygen skin care treatment, then contact OXYJET UK today. OXYJET UK realise the benefits of oxygen jet facial therapy and treatments and lead the way when it comes to oxygen skin care in the UK. To get in touch with OXYJET, simply fill in our contact form, email us at: email@example.com or call us on 01775 722243, and a member of our helpful team will be happy to assist you.
Patented technology made in Germany.

subset: commoncrawl


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Sources: ml CME announces to launch Bitcoin futures - October 31, 2017 Bitcoin value: 6121.79 Bitcoin value 10 days later: 7255.21 View Event #72 on Chart CME Group announced that it plans to introduce trading in bitcoin. Sources: SegWit2X Cancelled - November 8, 2017 Bitcoin value: 7143.47 Bitcoin value 10 days later: 7844.44 View Event #73 on Chart Bitcoin was scheduled to upgrade around Nov. Ml BlackRock looks into crypto and blockchain - July 16, 2018 Bitcoin value: 6336.16 Bitcoin value 10 days later: 8226.95 View Event #94 on Chart Bitcoin jumped as the news spread that BlackRock sets up a working group to look into cryptocurrencies and blockchain. Within hours of the article being published, Wright's existing online presence was mostly removed from the web. Two days later, regulatory issues surrounding money transmission compel the popular bitcoin exchange and services firm TradeHill to terminate its business and immediately begin selling its bitcoin assets to refund its customers and creditors. Hes now the owner of a reported 403 bitcoins, and while the cybercurrency has been on a bit of a bumpy ride lately, at Thursdays price. 1 Sources: Chinese Government Bans Financial Institutions From Using Bitcoin - December 5, 2013 Bitcoin value: 1022.37 Bitcoin value 10 days later: 839.93 View Event #27 on Chart Putting its first restraints on Bitcoin's surging popularity, the People's Bank of China declares. Only time will tell when/if this prediction is reached, though.
Bitcoin, exchange Rate, bitcoin, live Converter
Sources:.S.Justice Department launches criminal probe into Bitcoin price manipulation - May 24, 2018 Bitcoin value: 7818.21 Bitcoin value 10 days later: 7608.5 View Event #89 on Chart The Justice Department has opened a criminal probe into whether traders. This number comes from a comparison to the 7 trillion global gold market. The Bitcoin payment option will be seamlessly enabled for all merchants on the platform. The glyph will be given the slot "U20BF bitcoin sign" and eventually will render with standard system fonts. This verification was later debunked by the Bitcoin community. Gold today is about 8 trillion. Bitcoin Games is a provably fair gaming site. Kay Van-Petersen 100,000 (by 2027) @kvp_macro, kay Van-Petersen is an analyst at Saxo Bank, a Danish investment bank which specializes in online trading and investment. Gox bitcoin exchange, a hacker downloads a slightly out-of-date copy of the website's user database, including email addresses and insecurely hashed passwords.
Braintree merchants need only sign up for a Coinbase account and link it to their Braintree account. The bigger block group called their currency Bitcoin Cash and effectively doubled the holdings of anyone who owned Bitcoin before August 1st. Org/story/147526 Bitcoin Protocol Bug Causes Hard Fork - August 15, 2010 Bitcoin value:.07 Bitcoin value 10 days later:.07 View Event #7 on Chart Using a peculiar quirk of the way computers process numbers, an unknown person creates a fraudulent transaction that generates. As the man who successfully predicted Bitcoins flow up to 2,000 by 2017, Kay Van-Petersens most recent estimate, perhaps a little optimistic, suggests that Bitcoin would then account for 10 of the volume in the foreign exchange market. The host of The Bitcoin Knowledge Podcast had based his prediction on a 200-day moving average. These targets were instead achieved by the end of 2017.
100 Complete, bitcoin Price
Coinsecure pledges to compensate customers from personal funds. Others in the Bitcoin community accused Hearn of purposely attacking Bitcoin in order to promote his new employer, R3 CEV, a startup focused on using blockchain technology to improve the operations of the global banking industry. Goldman still sees the regulatory environment as ambiguous, according to Business Insider, which cited people familiar with the matter. Soon after, a copy of the database is leaked and is used to launch attacks against accounts held by users of the MyBitcoin online wallet service who share the same password on both sites, resulting in thefts of over 4,019 BTC from roughly 600 wallets. Hes set a bold price target for Bitcoin of 700,000about 175 times the current Bitcoin price of nearly 4,000. The exchange platform is to remain separate from their Bitcoin outlet operation, which in contrast, allows customers to buy and sell Bitcoins directly from Coinbase. The total market cap of all cryptocurrencies is now 414 billion. Sources: IRS Declares Bitcoin To Be Taxed As Property - March 26, 2014 Bitcoin value: 581.52 Bitcoin value 10 days later: 453.05 View Event #31 on Chart The IRS policy document declares Bitcoin to be property, not currency, subject. The Shanghai Composite index lost.6. However, more and more major bitcoin developers dropped their support for the upgrade in the last few months. Roger Ver 250,000 (no date) @rogerkver, roger Ver is an early investor in Bitcoin and related blockchain startups. Over the next 24 hours, the entire BearWhale order is fulfilled on the exchange via buy orders. Sources: ml Newsweek Claims Dorian Nakamoto is Bitcoin's Creator - March 6, 2014 Bitcoin value: 662.57 Bitcoin value 10 days later: 631.25 View Event #30 on Chart In an article titled "The Face Behind Bitcoin journalist Leah McGrath Goodman writes.
Ethereum, one of its chief rivals, has also seen big gains. Mark Yusko 400,000 (no date) @MarkYusko, mark Yusko is the billionaire investor and Founder of Morgan Creek Capital. Bitcoin value: 6418.2 Bitcoin value 10 days later: 6538.76, view Event #99 on Chart, a Japan-based cryptocurrency exchange called Zaif has been hacked, losing.7 billion yen (about 60 million worth of cryptocurrency including 5,966 bitcoins. And Does your business accept funds from customers and send the funds based on customers instructions (Money Transmitter)? Plus: Bitcoin needs government regulation to rise further, Morgan Stanley says. Lee initially set a Bitcoin price target for 11,500 for mid-2018, and then increased it to 20,000 as the cryptocurrencys intrinsic value increased. Sources: New York State Releases the BitLicense - June value of one bitcoin in dollars 3, 2015 Bitcoin value: 226.9 Bitcoin value 10 days later: 232.05 View Event #44 on Chart Superintendent of New York State Department of Financial Services, Benjamin Lawsky, released a set of customized. 8 launched an investigation into cryptocurrency-related services provided by local banks amid criticism that recent government measures are having little impact on cooling the markets. Sources: /wiki/Genesis_block m/email protected/ml). Sources: DHS Seizure Warrant Against. Novogratz had already invested 150 million in the cryptocurrency space, having collected more funds from outside sources, mainly wealthy individuals/families and fellow hedge fund managers. Sources: Bitcoins Savings Trust Halts Payments - August 17, 2012 Bitcoin value:.31 Bitcoin value 10 days later:.18 View Event #15 on Chart Promising consistent weekly interest returns of 7 to its creditors, Trendon. Or, maybe they are sellers who want to see if accepting payment in Bitcoin is good for business.
What Is The Fundamental Value of Bitcoin?
Customers, and the future of Bitcoin's legal status becomes ever more uncertain. Gox's servers, causing trades to stutter and fail. Moas has also compared the wealth proposition of cryptocurrencies to that of the dot-com boom. Sources: Mining Pool Reaches 51 - June 13, 2014 Bitcoin value: 598 Bitcoin value 10 days later: 592.28 View Event #33 on Chart Due to 's popularity and partnership with to sell mining shares of their own mining hardware. We want money to be as stable and reliable as possible, to serve as a store of value and a basis for long-term contracts.
Shrem had entered a plea bargain which involved surrendering 950,000 to the US government and pleading guilty to aiding and abetting the operation of an unlicensed money transmitting business. Gox - May 14, 2013 Bitcoin value: 114.33 Bitcoin value 10 days later: 128.8 View Event #21 on Chart When. Ml Winklevoss twins Bitcoin ETF is rejected by the SEC - July 26, 2018 Bitcoin value: 8226.95 Bitcoin value 10 days later: 7275.01 View Event #95 on Chart The.S. Incorrect: Ran Neuner 50,000 (by 2019) @cryptomanran Ran Neuner, the host of cnbcs show Cryptotrader and the 28th most influential Blockchain insider according to Richtopia, had claimed that Bitcoin will end 2018 at the price point of 50,000. Id11609707 nja/satoshi Steam Accepts Bitcoin - April 27, 2016 Bitcoin value: 461.08 Bitcoin value 10 days later: 460.85 View Event #57 on Chart The popular gaming platform Steam began accepting Bitcoin as payment for video games and other online media. One of the stories that illustrate this growth best is that of two pizzas, which were bought for 10,000 Bitcoins, on May 22, 2010, by a Florida developer by the name of Laszlo Hanyecz. When the iafcu determines that it can not reasonably handle the myriad regulatory issues surrounding Bitcoin, Tradehill is forced to halt operations and return customers' funds.
Those 10,000 Bitcoins (at 4,000 per bitcoin) would be worth over 40 million today, pitted against the 40 or so they were worth then. This pre-programmed limit to inflation is a major driver of the currency's economic controversy, value appreciation and speculation. Others in the Bitcoin community denounced the meeting as being inconsequential value of one bitcoin in dollars as the parties involved represented a small handful of Bitcoin companies and special interest groups. The Bitcoin Cash (BCH) Ecosystem at a Glance. Born in the US and now with citizenship in Saint Kitts and Nevis, Ver started his business career with a computer parts business,.


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Showing 1-2 of 2
Price: $14.50
Publisher: Thomson/Heinle: 1998
Edition: Fifth Edition
Seller ID: 11873
Condition: Very Good+ with no dust jacket
Clean and bright without marks of any kind. Edge wear has resulted in lightly soiled pages at lower corner page edges and bottoms. Otherwise a clean copy showing slight curling of card covers and a few pages. View more info
Price: $40.00
Publisher: Mark H. Newman, School Book Publisher: 1843
Edition: Twelfth Edition
Seller ID: 17908
Condition: Very Good with No dust jacket as issued
1843 Twelfth edition in quarter leather (spine only) with black label, aned green marbled boards. Heavy corner wear and marked edge wear, this copy is tightly bound. A bonus is the high quality pencil doodles on the endpapers by the former owner - all remarkable in their detail. Pages are tanned and the book as a whole is better than graded. View more info


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Midlife Crisis Band (MLC) been playing for 4 years in the Syracuse, NY area. They have a music studio right here on State Fair Blvd. across from Daniella's Steakhouse. Playing Classic Rock and Grace DeJohn (lead vocals and keys) Originals, they Rock the House!
Over the Fair's 13 days, the Chevrolet Music Festival at the New York Experience Stage will feature several national touring acts along with a mix of major bands from across Upstate New York and national touring tribute bands. The New York Experience Stage is located on the west end of the Fairgrounds


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8 Simple & Effective Hair Masks To Treat Dull & Damaged Hair
With constant exposure to dirt, pollution and the various chemicals we use, it becomes a difficult task to maintain healthy and strong hair. Hair loss, hair damage, dull and damaged hair are a few issues we constantly battle with.
Salon treatments and using products infused with harmful chemicals won't do the trick. Home remedies, however, can help tackle these issues. More and more people are deviating towards home remedies as they contain natural ingredients that nourish your hair without causing any harm.
Although, it may take a little longer, home remedies are your best bet to replenish dull and damaged hair. They nourish your hair and repair the damage done to it.
So, here we are with the best home remedies that can help you replenish and repair the dull and damaged hair. Have a look!
1. Egg White, Honey And Coconut Oil
Loss of protein from hair is one of the main reasons for dull and damaged hair. Rich in proteins, egg white helps to combat the protein loss and thus revives the damaged hair . [1] Honey locks the moisture in your hair and conditions your hair. [2] Coconut oil prevents protein loss from the hair and thus prevents hair damage. [3]
- 1 egg white
- 1 tbsp coconut oil
- 1 tsp honey
Method of use
- In a bowl, separate an egg white from the yolk.
- To this, add the coconut oil and honey.
- Whisk all the ingredients together until you get a frothy mixture.
- Dampen your hair and apply the mixture on your hair and scalp.
- Gently massage your scalp for a few seconds.
- Wrap a hot towel around your head.
- Leave it on for 20 minutes.
- Rinse it off later.
- Let your hair air-dry.
2. Shikakai And Coconut Oil
Shikakai is used since ancient times for its amazing benefits for hair. It cleanses the hair and promotes the growth of healthy and strong hair. [4]
- 1 tbsp shikakai powder
- 1 cup coconut oil
Method of use
- In a bottle, pour the coconut oil.
- Add the shikakai powder to it and give it a good shake.
- Let it rest for about 2 weeks.
- Shake the bottle every now and then.
- Take some of this mixture, gently massage it on your scalp for 5-10 minutes and work it into the length of your hair.
- Leave it on for 25-30 minutes.
- Rinse it off using a mild shampoo and cold water.
3. Papaya And Yogurt
Papaya contains the enzyme papain that not only nourishes the hair, but also conditions it. [5] Yogurt contains proteins and fatty acids that nourish the hair to treat dull and dry hair. [6]
- 2-3 slices of ripe papaya
- 1 cup yogurt
Method of use
- In a bowl, mash the papaya into pulp.
- Add yogurt to it and mix both the ingredients together well.
- Apply this mixture to your scalp and hair.
- Leave it on for 30 minutes.
- Rinse it off later.
4. Methi, Yogurt And Coconut Oil
Methi has vitamin C that nourishes the hair follicles and facilitates collagen production on the scalp. [7]
- 2 tbsp methi powder
- ½ cup yogurt
- 1 tbsp coconut oil
Method of use
- In a bowl of water, add the methi seeds.
- Let it soak overnight.
- Grind them in the morning to make a paste.
- Add yogurt and coconut oil to it and mix everything together well.
- Apply the mixture on your scalp and hair.
- Leave it on for 30 minutes.
- Rinse it off later.
5. Olive Oil, Hibiscus & Milk
Olive oil penetrates deep into the hair follicles and possesses antioxidant properties that protect your scalp from free radical damage and replenish dull hair. Hibiscus contains vitamins B1 and C that rejuvenate and repair the damaged hair. [8] Milk contains proteins that condition your hair and add a natural shine to it.
- 1 tbsp extra virgin olive oil
- 2 tbsp raw milk
- 6-7 hibiscus flowers
Method of use
- In a bowl of water, soak the hibiscus flowers.
- Let it soak overnight.
- Grind them in the morning to make a paste.
- Add olive oil and milk to this paste and mix everything together well.
- Apply this on your scalp and hair.
- Leave it on for 30 minutes.
- Rinse it off later.
6. Aloe Vera And Egg White
Aloe vera is a storehouse of vitamins and minerals that nourish your scalp to rejuvenate your hair and promote hair growth. [8]
- ½ cup aloe vera gel
- 1 egg white
Method of use
- Mix both the ingredients together in a bowl to make a paste.
- Apply this mixture on your scalp and hair.
- Leave it on for 30 minutes.
- Rinse it off later.
7. Henna And Mustard Oil
Henna nourishes your hair and improves hair elasticity to replenish dull and damaged hair. Mustard oil contains antibacterial and antifungal properties that help to maintain a healthy scalp and thus ensures healthy hair growth.
- 1 tsp henna powder
- 2-3 tsp mustard oil
Method of use
- Mix both the ingredients together in a bowl.
- Apply the mixture on our hair.
- Leave it on for about 2 hours.
- Rinse it off using a mild shampoo.
8. Banana And Honey
Banana is rich in vitamins, potassium and natural oils that nourish the hair. It improves hair elasticity and makes the hair smooth to prevent hair breakage and hair damage. [9]
- 1 ripe banana
- 1 tbsp raw honey
Method of use
- In a bowl, mash the banana into pulp.
- Add honey to it and mix both the ingredients together to make a paste.
- Apply this paste on your scalp and hair.
- Leave it on for 30 minutes.
- Rinse it off thoroughly using lukewarm water.
- Shampoo your hair as usual.
- [1] Cho, D. Y., Jo, K., Cho, S. Y., Kim, J. M., Lim, K., Suh, H. J., & Oh, S. (2014). Antioxidant effect and functional properties of hydrolysates derived from egg-white protein.Korean journal for food science of animal resources,34(3), 362.
- [2] Burlando, B., & Cornara, L. (2013). Honey in dermatology and skin care: a review.Journal of Cosmetic Dermatology,12(4), 306-313.
- [3] Rele, A. S., & Mohile, R. B. (2003). Effect of mineral oil, sunflower oil, and coconut oil on prevention of hair damage.Journal of cosmetic science,54(2), 175-192.
- [4] Khanpara, K., Renuka, V., & Harisha, C. R. (2012). A detailed investigation on shikakai (Acacia concinna Linn.) fruit.Journal of Current Pharmaceutical Research,9(10), 06-10.
- [5] Boshra, V., & Tajul, A. Y. (2013). Papaya-an innovative raw material for food and pharmaceutical processing industry.Health Environ J,4(1), 68-75.
- [6] Cloninger, G. (1981).U.S. Patent No. 4,268,500. Washington, DC: U.S. Patent and Trademark Office.
- [7] Almohanna, H. M., Ahmed, A. A., Tsatalis, J. P., & Tosti, A. (2018). The Role of Vitamins and Minerals in Hair Loss: A Review.Dermatology and therapy,9(1), 51–70. doi:10.1007/s13555-018-0278-6
- [8] Shahi, Z., Mehrizi, M. K., & Hadizadeh, M. (2017). A review of the natural resources used to hair color and hair care products.Journal of Pharmaceutical Sciences and Research,9(7), 1026.
- [9] Kumar, K. S., Bhowmik, D., Duraivel, S., & Umadevi, M. (2012). Traditional and medicinal uses of banana.Journal of Pharmacognosy and Phytochemistry,1(3), 51-63.


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Tottenham Hotspur manager Jose Mourinho says he "would not know" how lengthy striker Harry Kane would be sidelined for with ahamstring distress.
Kane, 26, suffered the distress true thru Tottenham's defeat at Southampton on Novel Yr's Day and became firstly dominated out until April after the membership talked about he wants surgical treatment.
READ MORE:I'm no longer an fool, I do know why Eriksen is no longer taking half in his perfect – Mourinho


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Level is the twelfth-largest chaos in Nigeria. Approximately here the centre of the country, it is physically unique in Nigeria correct to its boundaries of elevated hills surrounding the Jos Plateau its head, and the entire upland itself. With natural formations of rocks, hills along with waterfalls, it derives its name from the Jos Plateau and has a population of around 3.
With an area of 26, square kilometres, the State has an ballpark population of about three million people. The ceremonial is named after the picturesque Jos Plateau Stuffy, a mountainous area wearing the north of the state with captivating swing formations. Bare rocks are scattered across the grasslands , which cover the plateau. Mature group porn pics.
Google maps and detailed facts of Nigeria, NG. This page enables you to explore Nigeria and its border countries Location: Western Africa, bordering the Gulf of Guinea , between Benin and Cameroon through detailed Satellite imagery - fast and easy as never before Google maps.


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Document › Details
Alligator Bioscience AB. (1/7/19). "Press Release: Alligator Bioscience Launches RUBY, a Novel Concept in Bispecific Antibody Formats". Lund.
> Priority filling submitted
> RUBY bispecific concept has been developed to achieve an outstanding stability, manufacturability and shorter development timelines
Alligator Bioscience (Nasdaq Stockholm: ATORX), announces the launch of a novel concept in bispecific antibody formats, RUBY. The RUBY concept gives Alligator competitive abilities to generate therapeutic antibodies that are both efficient and highly manufacturable in a shorter time period than what is currently possible.
The bispecific format RUBY significantly strengthens our existing technology platform. We now have all technologies in-house to generate virtually any future bispecific therapeutic antibody, tailor-made for immuno-oncological applications, said Per Norlén, CEO of Alligator. Moreover, the RUBY format allows for superior binding and dramatically shortened development timelines which is a crucial competitive factor.
Bispecific antibodies have emerged as the most promising and efficient concept in human immunotherapy of cancer. It is currently acknowledged that bispecific compounds have the potential to be more tissue specific, have higher potency and efficacy and render drugs with mechanism of actions far beyond what can be achieved with monoclonal antibodies.
RUBY is a novel IgG-like bispecific antibody format that allows Plug-and-Play generation of bispecific compounds, from any two antibodies, with excellent stability and manufacturability properties. Moreover, RUBY allows for unrestrained dual binding to two targets (with a bivalent interaction) in a manner similar to the natural antibody-antigen interaction. The format abolishes the need for further optimization and enables Alligator to move drug candidates faster from preclinical to the clinical phase. This positions Alligator with a competitive edge in the field of Immuno-oncology, to deliver pipeline leads at increased speed for successful out-licensing.
For further information, please contact:
Cecilia Hofvander, Director Investor Relations & Communications
Phone +46 46 540 82 06
E-mail: email@example.com
The information was submitted for publication, through the agency of the contact person set out above, at 1:00 pm CET on January 7, 2019.
About RUBY
RUBY bsAb consist of immunoglobulins fused via the C-terminal heavy chains to Fab domains. The Fab domains are attached via their light chains. This composition is novel and allows for generation of bispecific antibodies with excellent stability, manufacturability, binding and function.
About Alligator Bioscience
Alligator Bioscience AB is a clinical-stage biotechnology company developing tumor-directed immuno-oncology antibody drugs. Alligators growing pipeline includes five lead clinical and preclinical drug candidates (ADC-1013, ATOR-1015, ATOR-1017, ALG.APV-527 and ATOR-1144). ADC-1013 (JNJ-7107) is licensed to Janssen Biotech, Inc., part of J&J, for global development and commercialization. Alligators shares are listed on Nasdaq Stockholm (ATORX). The Company is headquartered in Lund, Sweden, and has approxi-mately 50 employees. For more information, please visit http://www.alligatorbioscience.com.
Record changed: 2019-01-08
More documents for Alligator Bioscience (Group)
- [1] Alligator Bioscience AB. (8/20/19). "Press Release: Alligator Bioscience Signs Antibody Agreement for Greater China with Biotheus Inc.". Lund....
- [2] Alligator Bioscience AB. (7/31/19). "Press Release: Alligator Bioscience Regains Global Rights from Janssen to CD40 Agonistic Antibody, ADC-1013 (JNJ-64457107)". Lund....
- [3] Alligator Bioscience AB. (12/11/18). "Press Release: Alligator Bioscience Starts Clinical Phase I Study with ATOR-1015. A First-in-class Bispecific CTLA-4 Antibody". Lund....
- [4] Alligator Bioscience AB. (1/18/18). "Press Release: Alligator Bioscience Appoints New VP Business Development". Lund....
- [5] Alligator Bioscience AB. (7/21/17). "Press Release: Aptevo Therapeutics and Alligator Bioscience Announce Plans to Co-develop Novel Bispecific Antibody for Tumor-directed Immunotherapy". Seattle, WA & Lund....
- [6] BioInvent International AB. (7/8/16). "Press Release: BioInvent Enter Process Development and Manufacturing Collaboration with Alligator". Lund....
- [7] Cobra Biologics Ltd.. (6/23/16). "Press Release: Cobra Biologics and Alligator Bioscience Extend Drug Development Partnership". Södertälje & Lund....
- [8] Alligator Bioscience AB. (8/12/15). "Press Release: Alligator Bioscience Announces Collaboration with Johnson & Johnson Innovation for the CD40 Agonistic Immuno-Oncology Antibody ADC-1013"....
- [9] Alligator Bioscience AB. (3/31/11). "Press Release: Alligator Bioscience AB Raises 43 MSEK in Directed New Share Issue"....
- [10] Alligator Bioscience AB. (6/14/10). "Press Release: Alligator Bioscience AB Appoints Sibylle Lenz as Chief Executive Officer. Internationally Experienced Pharmaceutical Executive Will Join Alligator Bioscience AG on 1st August 2010". Lund....
To subscribe to our free, monthly newsletter for the European life sciences, please send an e-mail to email@example.com and simply fill the subject line with the word »LSE Newsletter«
To get even more information, please take a look at our [gs] professional services offering and read the gene-sensor Product Flyer [PDF file]
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STAUNTON, Va. -- Mary Baldwin University has named Michael Bair as head coach for the men's soccer program, which this fall is set to begin the first season of varsity play in university history.
"Coach Bair joins us at a significant time, as several MBU men's teams begin competing in the NCAA Division III and the USA South Athletic Conference," said Vice President for Student Engagement Ernest Jeffries. "I'm confident his depth in soccer skills, coaching and recruiting and his collaborative nature will grow our men's soccer program aligned with our university's vision, mission, and goals."
Bair comes to MBU after nine seasons as the assistant coach for the men's soccer team at Geneva College in Pennsylvania, also NCAA DIII.
"It's an honor to be named the head coach of MBU men's soccer," Bair said. "Mary Baldwin is a distinctive small university with an impressive history, and I want to thank Dr. Jeffries for giving me the opportunity to lead its new NCAA Division III men's soccer program."
Since 2010, Bair was an integral part of effectively recruiting classes that contributed to Geneva's nine-‐year record of 109-‐49-‐25 (.664), and he helped lead the Golden Tornadoes to consistent post-‐season play, including the Presidents' Athletic Conference (PAC) semifinals and higher for six straight years. Other features of his competitive record are a PAC Tournament title, one NCAA Tournament appearance, and one Eastern College Athletic Conference Division III semifinal appearance.
Bair coached multiple team members who were named all-region and all-‐conference teams, and most recently, 10 Golden Tornadoes earned spots on the PAC Academic Honor Roll. The National Soccer Coaches Association of America (NSCAA) honored Bair and the Geneva men's soccer coaching staff as a Regional Coaching Staff of the Year in 2016.
Bair follows Robert "Bob" Rose who recruited two classes for MBU's first-‐ever men's soccer team while managing the construction of SMA Worth Field and an overhaul of the university's Physical Activities Center. The players were competitive and cohesive on the field and in the classroom, and several set the example as scholar-‐athletes last year with grade point averages of 3.5 and above.
"The players are motivated to be competitive in the conference right away, and so am I," Bair said. "I am excited to build something special with this great group of student-‐athletes."
Bair has also been active in Western Pennsylvania's club soccer community, coaching U10 through U19 teams for the past eight years. Since 2017, he's also been a head coach of the Pennsylvania West Olympic Development Program.
Bair holds a United Soccer Coaches (formerly NSCAA) National Diploma as well as Goalkeeping Level I and II Diplomas. He earned his master of arts in higher education and bachelor of science in business administration from Geneva College where he also played collegiate soccer.
The Fighting Squirrels open their first NCAA soccer season on Aug. 30 at Shenandoah before starting their home slate on Sept. 14 against Maryville. The women's team will open SMA Worth Field on Sept. 4 against Hollins University, which is slated to begin at 5 pm.
MBU thanks Brig. Gen. Teresa Djuric, commandant of cadets for the Virginia Women's Institute for Leadership, who led the head coach search committee consisting of faculty, staff, and returning players.


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Investor Reactions to PCAOB Inspection Reports
42 Pages Posted: 13 Apr 2011
Date Written: April 12, 2011
This study examines whether PCAOB inspection reports succeed in providing a meaningful signal of audit quality. We find a statistically and economically significant market response to the issuances of 224 first-round and 134 second-round inspection reports between January 2005 and March 2010, indicating that inspection reports have information content. Moreover, the observed market response is systematically associated with cross-sectional variation in report-specific determinants of inspection report informativeness, indicating that the market response can be reliably attributed to the information in the inspection report. We also find that at least part of the market response to the publication of PCAOB inspection reports can be attributed to revisions in investors' beliefs about accounting information quality. This paper takes a first step to assess the informative value of the PCAOB inspection reports to investors, who could be regarded the ultimate consumers of the audit. It also contributes to the literature on the value of the audit by providing evidence that a commonly available signal of audit quality has an economically significant value effect.
Keywords: PCAOB inspection reports, audit quality, stock market response, precision of accounting signals
JEL Classification: M41
Suggested Citation: Suggested Citation
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June 18, 2018
A couple days ago, I received a box of all the medications I will be using for IVF. I knew the box was coming, since I was the one who ordered it, so there was no surprise when I saw the package on the doorstep.
What WAS surprising, however, was how LARGE the box was. I was told that there would be some refrigerated medications packed in ice, so I assumed that was the reason for the box size.
The refrigerated items took up a small corner of the box. The rest was... well, the rest (I'm not going to lie: There was a moment where I got a little dizzy thinking about all those medications going into my body). I was immediately overwhelmed by it all. I tried combing through to see what was what but I just couldn't. There was even a packing slip that suggested I take inventory of the supplies.
Yeah, nope.
I had to walk away, far away.... outside, to be exact, just so that I could catch my breath. I tried looking at the box again, a little later, to see if I could handle it then, but I just couldn't. So I closed it up and ignored it. I didn't move it, didn't touch it, didn't look at it. For days.
However, my "shot-teaching" appointment with the doctor was a couple days later so I did have to build up some courage... but it was just enough to grab the one medication I had to bring with me to the appointment. That morning, I squared up to the box, took a deep breath and dove my hand into the contents quickly. Once I had my hand on the little package I yanked it out and closed the box back up.
I was actually pretty proud of myself for finally going into the box. Maybe the worst was over?
Again... nope.
At my appointment, I was given the medication calendar and the shot instructions. My head was spinning and I had to tell myself not to cry. I know this is the path that we've chosen and it will all work out the way it's supposed to- but I think I was just completely overwhelmed. My husband was out of town and I was trying to line my work schedule, child-care schedule, IVF schedule and personal calendar up in my head. All the while, making a mental note of medication administration days and times AND juggling a fundraiser 'to-do list'.
I am surprised that made it out of that appointment without having a complete breakdown, but I did. Then I made it through the rest of the day fairly unscathed... maybe just a little fried.
It actually wasn't until the next morning when I was staring the needle in the face that I really started to lose it. I don't know if it was lack of sleep, tons of stress or just the idea of poking myself with a needle, but I had a few tears. I just sat there at the counter and let myself feel whatever it was that I was feeling.
I stared at the syringe and it stared at me. I think we hated each other. Then I took a deep breath and had myself a little conversation with that guy. Okay, you little jerk... I'm doing this and you're going to cooperate. Keep in mind: I can break you.
And then I did it. Giving myself a shot was actually physically easier than I was making it out to be- but the mental load is still heavy. While it didn't feel great, it also didn't hurt too bad. There was just a little stinging and some localized, but super minor, discomfort. I've done it twice now but I still have quite a bit more to go. An entire box, actually.
I think the bottom line in all of this is that it's not a light/easy/uncomplicated thing we are doing here. I need to allow myself to feel whatever it is that I'm feeling. I think it's natural to be uncomfortable with the unnatural process we are going through. I imagine that most, if not all, couples doing IVF feel some level of apprehension and stress at some point.
Or, at least I hope they do... otherwise, I'm just a big wimp.
And, I still don't know if I have all the medications.


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It's a brisk November night in Northern California when the Golden State Warriors zoom out to their most prolific quarter of the young 2012-13 season. They score 39 in the first period – with tall two-guard Klay Thompson dropping eight in the first two minutes and change – on the way to a balanced, almost easy 10-point win over the Cleveland Cavaliers.
The game is littered with moments that speak to an ongoing evolution in Oakland: a perfect no-look drop pass from new center Andrew Bogut to streaking point man Stephen Curry for a baseline bucket; a nimble alley-oop from new acquisition Jarrett Jack to power forward David Lee; a big three late from surging rookie Harrison Barnes; and, most importantly, a resilient team defense that stymies the snap-quick Cavalier backcourt when pressure mounts.
But in the bigger playbook of Bay Area pro basketball – wherein the Warriors look to shake off the heavy shackles of loserdom and claim a place among the National Basketball Association's elite – a more telling moment happens an hour before, with zero scoreboard flash or crowd roar.
It's the moment when new club General Manager Bob Myers, a former college basketball reserve, talk radio host and successful player agent – and, at 37, the third-youngest GM in the league – sits down for dinner. He doesn't dine with the owner, major sponsors or Head Coach Mark Jackson, nor with player captains, longtime beat reporters, veteran season ticket-holders, his family or his laptop.
He dines with bloggers.
GMs have long been defined far more by distance and secrecy than accessibility and candor, more by hard-core basketball strategy than philosophical reflections. But Myers doesn't belong to that era, just like his Warriors – already buoyed during Myers' short tenure by savvy free-agent signings and arguably the best draft in franchise history – no longer belong in the basement.
Bay Area News Group basketball beat writer Monte Poole recently called out "a habit the Warriors have perfected over the years": losing.
"They lost games during which they played well, lost games when they deserved to lose, lost games because they simply gagged away the final minutes," he wrote.
Because of those painful bricks – the Warriors have made the playoffs just once in 18 long years – few accuse the organization of being ahead of the game. But as its venture-capital-minded ownership pioneers an openness to fans and the media, and top-to-bottom developmental league strategies – by way of boho Santa Cruz, of all places (see story, p. 24) – that's precisely where they find themselves. As words like "trust," "transparency" and "communication" surface more than rebounds, steals and assists, the Warriors are in a place that feels more like a sensitivity retreat in Big Sur than a front office in the hyper-competitive NBA Western Conference.
But such is life when the team's relatively new ownership group – which bought the team in 2010 for $480 million – is a blend of creativity and cunning whose wild success leans toward technology and Internet startups. Their field doesn't exactly lend itself toward conventional thinking. So out goes the old GM model that veteran executive and Warriors VP Jim Weyermann knows.
"Usually you see this huge division and the isolation of basketball ops guys like Bob from everyone else," he says. "They're kinda like the president of the United States – no, the pope," he says. "You're not supposed to even whisper. Don't let him hear you breathing."
Myers credits team co-owner Joe Lacob, a self-made man who put himself through college, grad school and Stanford business school, made partner at Silicon Valley's marquee venture capital firm, participates regularly in the AT&T Pebble Beach Pro-Am and runs pick-up games with Warrior employees.
"If your owner is mingling with ticket sales staff, making himself available, it trickles down," Myers says. "He comes from a venture world where a 23-year-old has the best idea in the room – or the city – so it's not a caste system. Our company embraces new thoughts and ideas, not old-time hierarchy.
"Joe would say, 'There's more than one way to do things.'"
Myers was Lacob's hire, one of the earliest examples of another trend the Warriors are leading: Younger chief executives shaped as much by business as by basketball.
Not long after 6-foot-6-inch Myers earned a walk-on roster spot with a UCLA team that would go onto win the 1995 NCAA national championship, he jumped into the world of player representation, earning a law degree by night and studying at the side of legendary basketball agent Arn Tellem. (Full disclosure: Myers and I became acquaintances at UCLA.) He emerged steeled by 13 years of intense negotiations and complicated contract, salary-cap and luxury-tax entanglements.
"Bob's background is representative of a new breed of GMs in the NBA," Lacob says. "We are building an NBA team ownership and management for the next generation."
The most successful GM of the last generation, NBA champ and Hall of Famer Jerry West, recognizes that – and validates the new leadership's nose for pedigree by his presence on the Warriors executive board.
"Go out and look at the people they've hired," West says. "It's people at the top of their class. In terms of a business standpoint, that's very impressive."
The new Warriors way, he adds, is an appropriate adaptation.
"They have a different idea of how to run a team," he says. "The league is so different than it was years ago, with so many issues to cover far beyond sport. Financial issues are much greater, with a new collective-bargaining agreement, and you have to be much more responsible to the press and the fans."
Myers' time doing the UCLA Bruin post-game report elevated his ability to articulate hoops with a rabid fan base. His agent days taught him several lessons that are already netting results – including, as he says, something directly from Tellem: "Never make decisions based solely on money."
That approach helped land super sixth and seventh men Carl Landry and Jarrett Jack in the offseason, two players who have proved invaluable so far. Landry, who's averaging nearly 15 points in just 26 minutes a game, is an early contender for Sixth Man of the Year.
"Myers has dealt with so many players," senior San Jose Mercury sports writer Tim Kawakami says. "He has an understanding about the ones who want to play hard and the ones who might not."
Their contributions, along with a bumper crop of three rookies who are each playing big minutes – something no other team in the league can claim, this year or any in recent memory – means the Warriors have been able to weather some bad luck.
Despite the absence of two injured players – wing Brandon Rush, a premiere shooter and the team's best perimeter defender; and Andrew Bogut, an all-star scoring-and-shot-blocking center – they're 8-6 and deeper, younger, taller and tougher than they've been in a decade. They're third in rebounding league-wide, another wildly dramatic turnaround after giving up more than 102 points a game last year and finishing an unseemly 20 games below .500.
"When we draft or sign a player," Myers says, "we're asking, 'Do they have room for growth; are they competitive; do they care about the craft?'"
In other words, they're breaking the habit.
"Traditionally we've been a small team and weaker defensively," Myers says. "We're trying to build with size that competes in half-court and can win on defensive end, not just scoring."
When Myers was told by then-UCLA coach Jim Harrick he had successfully made the squad as a walk-on – an awkward, albeit hustling, player who would go on to become a crowd favorite, evoking chants of "B-O-B, Bob!" – he couldn't bring himself to tell anyone. Not his parents, not his pals, not his girlfriend.
"I didn't want to be compromised in case it didn't work out," he says.
That feeling disposed him beautifully for the life of an agent.
"That's the thing about representing players," says former Duke University star Lee Melchioni, who helped fill Myers' void after he left his agent post at Wasserman Group for the Warriors. "It's definitely fluid. Players switch agents and recruitment is cutthroat. You must have a contingency plan for every situation. It comes into play constantly when running an NBA team, whether it's injuries, free-agent signings or underperformance."
As does an insane work ethic, the kind that eventually earned him a college scholarship at UCLA.
"The best GMs seem to be in constant motion," Kawakami says. "They don't always make a ton of moves, but you always hear about them considering them. Myers is something like that."
True to the transparency era, Myers isn't shy about discussing demands or how he handles their maddening aspects.
"You're so invested emotionally in your team, it's probably unhealthy," Myers says. "You can control work ethic, control culture to some degree; but you can't control injuries. So you put in work, put in time, and have to trust the results."
"Trust" is suddenly the operative word at Oracle Arena. Trust primarily built through truth and direct talk.
"As GM, I'm communicating a lot – with the coach, doctors, trainers, ownership," Myers says. "People mistake that players, and people, can't handle the truth. Sometimes it isn't pretty, but everyone would prefer to hear it."
Fans love that more than anyone – which is partly why he's eager to make an unprecedented amount of front-office appearances on TV to tell fans, "Yes, I'm worried about injuries to our stars; yes, it's hard to compete in the free-agent market; yes, I'd prefer if my $14-million center outplayed the $1-million rookie; and, yes, fans deserve better than they've gotten historically."
One TV host, likely echoing viewers, recently thanked Myers for his honesty, an unofficial first for sports media working with typically slippery execs.
In giving traditional media more candor – and bloggers more access (and dinner) – he trusts the fan base with more information than ever before. In giving time to previously neglected business-side staff, he's reminding organizations everywhere that if you can see what the boss is doing and thinking, trust comes along for the ride. And when players can take that type of buy-in to the floor – trusting each other to know and execute their roles – only good things happen.
"He's not afraid to tell the truth," Weyermann says. "In the 10-second sound bytes of our lives, the most profound thing I can say about the Warriors is, we're not afraid to explain what our choices are. We don't have trouble doing that. We don't hide from tough issues."
Lacob describes a desire "to connect directly with the team's fans and open the lines of communication."
Later he emails the Weekly about how Myers fits into that vision.
"The handling of the media is a much bigger responsibility for a GM today than ever before," he writes. "So far, Bob has earned high marks from the media for his concise, clear, direct and open style. Transparency is something we view as a hallmark of our organization. If there is something that others might miss about Bob, it is this ability to come across, and in fact actually be, clear, concise, direct and transparent with the media and within our organization."
"Transparency, accessibility, trust and innovation come from our owners' success in business," Myers says. "Both Joe Lacob and [co-owner] Peter Guber have found success employing those ideals. We're an extension of their philosophies."
Trust may not be a stat that SportsCenter tracks, but it's certainly a quality the team treasures. Besides, when it comes to playing basketball in a prison yard – where there are rules to discourage taking hostages, and the penalty for an errant whistle might be a bullet – trust is a very valuable thing.
There are few NBA general managers who quote Ralph Waldo Emerson for members of the media.
"'Don't waste life in doubts and fears,'" he told reporters when asked to evaluate the uncertain season ahead. "'Spend yourself on the work before you, well assured that the right performance of this hour's duties will be the best preparation for the hours and ages that will follow it.'"
There are probably fewer still who hang 39 points on the board during a game at San Quentin State Prison.
That came this fall as Warriors employees and increasingly relevant rookie small forward Draymond Green visited for a game against the San Quentin team. (A then-injured Green stuck to dominoes.)
While carefully selected inmates (who practice regularly) dearly value the privilege to play four 12-minute quarters with refs and scoreboards against visiting teams, that doesn't stop max-security guards from issuing repeated reminders: Hostage takers will be shot through the hostage, running is restricted to the court, and duck calls replace ref whistles, as they are the guards' dead-serious distress signals. Other twists at the home to California's Death Row: Holding cells are locked at check-in, hundreds of inmates watch their guests closely from the metal bleachers, and the adjustment center – where "Dating Game Killer" Rodney Alcala and a number of serial killers live – looms.
Warriors coach and former NBA point guard Mark Jackson shared the ball beautifully, and also shared a note of hope with San Francisco Chronicle reporter Rusty Simmons after the game.
"I went in thinking it was a chance to impact lives, and I came out knowing that it had impacted mine," Jackson said. "I went in with my heart and prayers going out to the victims of the mistakes [they] made. That remained, but I came out with my heart and prayers going out to those guys in there, too.
"I'm sure society and the powers-that-be can treat them like animals, but they're human beings who made mistakes. It's important to let them know that we've still got love for them, we're still pulling for them, and they can still win in spite of huge losses."
Edgy sports journalism site Bleacher Report pulled a different takeaway.
"The Warriors and their supporters need to believe there's something better out there than season after season of lottery picks… just like the inmates have to believe there's a reason to be optimistic about the future," Grant Hughes writes. "And if you think it's a stretch to compare prison inmates to Warriors fans, you obviously haven't been around the Bay Area for the last 20 years of hard time as a Dubs loyalist."
At the start of the season, Sports Illustrated decided it's "a safe bet that… [the] Warriors aren't going to make the playoffs."
"They'd be better served," Ian Thomsen wrote, "to be focused on the future."
Somebody forgot to tell the Warriors.
"We're not interested in talking about 'down the road,'" Jerry West says. "We've got this year to worry about. I'm a person who believes in now."
A defense that was 28th in the NBA last year, and has been in the top 10 only once since 1978-79 – a decade before star guard Stephen Curry was born – is now fourth. As of press time, the Warriors lead the mighty Los Angeles Lakers by a game and are tied with the L.A. Clippers for first place in the Pacific Division.
"Didn't see this coming, frankly," ESPN's NBA beat writer Mark Stein observes. "Despite playing eight of their first 14 games on the road – and playing them, for the most part, without the injured Andrew Bogut and Brandon Rush – Golden State has matched the team's best start to this point since the 'We Believe' Warriors."
But as the organization traffics in honesty more and more, the most telling truth is that it's not good enough.
"Current standards are insufficient to get the national and international reputation our organization needs to be one of the top in professional sports," Weyermann says. "That's our goal. This whole experiment, money and resources into this, is a direct testament of understanding that to be in the elite, you have to be best in everything you do, from top to bottom. Not easy to do coming from the starting place we were coming from."
Calling a $480 million investment an experiment isn't standard. But neither is the amount of losing Oakland fans have endured – or coaches and organizations who giving a shit about three-time felons.
The owners' competitiveness presents another edge.
"I've been in sports all my life," Weyermann says. "I know [Buster] Posey, [Tim] Lincecum, LeBron [James], [Allen] Iverson, Gary Payton – but nobody who wants to win more than Joe Lacob."
So is the outreach to bloggers. Ben Cruz of WarriorsWorld.net was part of the group that met with Myers.
"I had never even heard of another team doing that," he says. "And Myers didn't have an agenda; he just wanted us to learn about thought process, how he wants to shape the team."
More news awaited.
"Myers has a plan," Cruz says. "He has a direction, which I find refreshing. That wasn't there before. They're trying to change the whole culture of the team."
Given the ways their faith has been shaken before, that means Golden State fans are discovering an unfamiliar feeling: trust.
To learn more about the Golden State Warriors visit www.nba.com/warriors
Ticket to History
• Given stadium construction, the S.C. Warriors will play their first seven of the 50-game season on the road - starting this Friday, Nov. 30, and returning right before Christmas to binge on home-crowd enthusiasm. More at 713-4393 or www.santacruzbasketball.com.
• Opening night four game "mini-packs" run $60-$140, include nightly giveaways.
• Fans can create six-home-game packages starting at $90 and receive a $20 merchandise card.
• Ten-seat ticket bundles rank among the most popular Christmas gifts.


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In their second match of the season, the Colt varsity soccer team lost a close and hard-fought contest at Lovington against the Wildcats.
The 'Cats built up a 2-0 lead in the first half, thanks to some NMMI miscues.
"It was the battle of beginning-of-the-season jitters," explained head Colt coach John Barbour. "We made some mistakes and they capitalized on them."
"We turned up the pressure in the second half," continued the coach "and that's when we got our goal. Their fullback was trying to pass back to their goalie, but our pressure forced him to kick it too hard and it went past the keeper and into the goal."
With the loss the Colts drop to 1-1 on the season. They'll next face another Wildcat team - this time 6A Clovis - again on the road, on Thursday, Sept. 6 at 6:00 PM.


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Researchers at Ruhr University Bochum (RUB; Germany) coupled nerve cell receptors to light-sensitive retinal pigments to understand how the serotonin neurotransmitter works and, therefore, learn what causes anxiety and depression.
Related: Optogenetics could lead to better understanding of anxiety, depression
Prof. Dr. Olivia Masseck, who led the work, researches the causes of anxiety and depression. For more than 60 years, researchers have been hypothesising that the diseases are caused by, among other factors, changes to the level of serotonin. But understanding how the serotonin system works is quite difficult, says Masseck, who became junior professor for Super-Resolution Fluorescence Microscopy at RUB in April 2016.
|With a method called optogenetics, Olivia Masseck (right) creates nerve cell receptors that are controllable with light. (Copyright: RUB, Damian Gorczany)
The number of receptors for serotonin in the brain amounts to 14, occurring in different cell types. Consequently, determining the functions that different receptors fulfill in the individual cell types is a complicated task. If, however, the proteins are coupled to light-sensitive pigments, they can be switched on and off with light of a specific color at high spatial and temporal precision. Masseck used this method, known as optogenetics, to characterize, for example, the properties of different light-sensitive proteins and identified the ones that are best suited as optogenetic tools. She has analyzed several light-sensitive varieties of the serotonin receptors 5-HT1A and 5-HT2C in great detail. Together with her collaborators, she has demonstrated in several studies that both receptors can control the anxiety behavior of mice.
To investigate the serotonin system more closely, Masseck and her research team is currently developing a sensor that is going to indicate the neurotransmitter in real time. One potential approach involves the integration of a modified form of a green fluorescent protein into a serotonin receptor.
|In a brain slice, Olivia Masseck measures the activity of nerve cells in which she switches on their receptors using light stimulation. Via the pipette a red dye diffuses into the cell, rendering them visible in the brain slice. (Copyright: RUB, Damian Gorczany)
This protein produces green light only if it is embedded in a specific spatial structure. If a serotonin molecule binds to a receptor, the receptor changes its three-dimensional conformation. The objective is to integrate the fluorescent protein in the receptor so that its spatial structure changes together with that of the receptor when it binds a serotonin molecule, in such a way that the protein begins to glow.
Full details of the work appear in Rubin Science Magazine; for more information, please visit http://rubin.rub.de/en/controlling-nerve-cells-light.


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Reliance Jio accuses COAI to be lobby for Airtel and Vodafone Idea
Updated : October 31, 2019 06:31 AM IST
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A Smith County grand jury has returned indictments for July, including three men's charges for murder, manslaughter, and kidnapping.
Mother's Day Murder
James Robert Smith III, of Tyler, was arrested for the Mother's Day shooting at a gas station in Tyler.
[RELATED] Tyler man arrested for Mother's Day homicide
According to the sheriff's office, deputies were called to the Food Fast gas station on Highway 64 W around 2 a.m.
When deputies arrived, a man, now identified as Donovon Reese, 27, of Tyler, was found dead inside a vehicle in front of the store.
[RELATED]: Smith County authorities investigating Tyler homicide
Through interviewing witnesses and the victim's friends and family, Smith was identified as the suspect.
Smith is being held on a $1 million bond. He has been charged with one count of murder and two counts of aggravated assault.
April Shooting
A 19-year-old Tyler man had his charges from an April shooting downgraded from murder to manslaughter.
Treyvon Maddox was initially charged with the first-degree murder of Keyundta Devor Barrett, 20, of Tyler. A grand jury only returned an indictment on manslaughter and deadly conduct discharging a firearm.
RELATED: 19-year-old charged with murder for April shooting
He was being held for unrelated drug charges, which he later pled guilty to.
Maddox is still in the Smith County Jail on $350,000 bond.
Teenage kidnapping
A Flint man was taken into custody back in April for allegedly kidnapping a woman.
Kody Rasmussen, 19, was caught after he led officers on a short pursuit and crashed his car.
RELATED: Flint man arrested after breaking into a home and kidnapping a young woman
He is accused of breaking into a woman's home and taking her daughter by force. The Smith County Sheriff's Office has not released a motive for the crime.


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Southern Tier Pumking vs Pumking
Pumpkin, pumpkin, pumpkin, PUMPKIN! It seems like every year the flavors of fall begin their spicy, sticky and sweet barrage on our taste buds closer and closer to beach season. Some people have called this slide into lunacy "Seasonal Creep" but we prefer to tag it with a what we feel is a more apro poe, Seasonal Sleaze.
That is right, Seasonal Sleaze. Pumpkin this and pumpkin that "season" is like a reeeeaaaalllllyyyy drawn out Shark Week where people go around telling anybody within earshot how much they loooovvvveee pumpkin. "Oh have you had the new pumpkin spiced latte at Suck a Ducks?", no we haven't but are sure you will fill us in. "Did you try the spicy pumpkin crusty holes from Dumpy Donuts?", nah kid we don't eat those but it sure looks like you enjoy them. This onslaught of spiced and iced goods lasts quite a long time and while people do seem to enjoy these "treats" we'd say it has nothing to do with pumpkin at all. In reality what do they love? They love sugar and spice and whatever tastes nice. These people do not actually love pumpkin or the flavor of pumpkins (or sharks for that matter) they love sweet, sugary shit. When they order a pumpkin beer they make sure they get a full brown rim job every time loads with spices and sugar.
These tweaks to established recipes move product. In fact, several local brewers have told us how much of their yearly profit comes in via selling their pumpkin ale and the size of the figure is frightful. With such a chunk of change tied in to "pumpkin season" we can see why they kick things off early. To these brewers, who have so much of their business dependent on a seasonal product, slumming it for a few months and squeezing every last dollar out of the great orange gourd means bringing in profits which allow them to experiment with other fun and less widely drooled over ales and lagers. Sometimes the beast must be fed and it seems each year the beast wants a beer with cinnamon, cloves and depending on where you live, a sugar crusted rim earlier and earlier. So yes brewers, we understand. Sometimes ya gotta do what ya gotta do but that doesn't mean we have to like it or at least not all of it.
Pumpkin ales certainly have their place in history (which we've discussed here). We have tried many of the different offerings put out by various brewpubs and breweries throughout the "season". However, each year it seems brewers and consumers are taking this love affair with the hearty pumpkin (or pompion as it was once known) to insane heights. Gone are the days of wading through a sea of standard Fall specialtiy ales which may or may not have a courtesy can of pumpkin tossed into their recipe. No, these days you can find a cornucopia of brews crafted in a variety of styles (porter, Belgian brown, stout) made with a variety of ingredients (yams, molasses, maple syrup and of course fresh pumpkin). While the season may be sleazy your drinking options are varied, nuanaced and often delicious.
With the leaves changing and pumpkins being harvested in quantity, it's that time of year when a pumpkin ale is appropriate. To celebrate (a bit) we here at Beer Loves Company decided to do something a little different. We took one of the (more) beloved sesaonal treats, Pumking by Southern Tier Brewing Company, and tasted it twice. What we mean to say is that we took a bottle last year and aged it in our secret cellars (behind 2 foot thick steel and all kindsa lasers) allowing it to sleep, like a little baby, until this fall. We then bought a fresh bottle this past August when the death grip of Seasonal Sleaze is really tight (and extra kung fu-y). Our plan? To drink these bottles side by side for a super scientific comparison. This was something we were looking forward to and turned out to be very enjoyable regardless of the crusty nature of Seasonal Sleaze. What follows are the findings of our ultra scientific experiment which took place on dark and stormy night (at a house built on an Indian burial ground) muuahahahahahaha HA! So reach for a bottle of something creepy or seasonal and enjoy.
We started with the 2012 vintage bottle of Pumking. The pour was much clearer than we expected and it seemed that the yeast, spices or a combination of both had settled out of suspension. The majority of the beer we poured from this bottle was extremely clear, with the exception of the last glass which was packed with mystery goodness. This last pour saw the spice and/or combo yeast sediment come out to play and made for a bolder, more intense flavor experience.
The body of the 2012 was a rich orange with copper hints, topped off with a bone white, foamy head that left clumps of lacing. A mellow, spiced undertone carried through the sip, with the alcohol and bitterness amped up. A slight warming was felt throughout the tasting and there was haunting sweetness present as well. We found the 2012 bottle of Pumking to be a touch more subtle on the pumpkin spice while the boozy taste bold flavors were turned up a notch.
The bottle of 2013 Pumking was stored in the same fashion as our 2012 bottle (though obviously not for quite as long) making sure things were kept, you know, sciencey. Though these bottle brothers were kept in identical ways we noticed undeniable differences from the second the 2013 was poured.
2013 had much more carbonation visible in it's body which was accented with sunset orange and was markedly more hazy than the 2012. The fluffy off white head formed by 2013 stuck around for longer than it's older brother's, but also eventually settled into a foam cap, leaving behind clumps of lacing. The 2013's aroma was heavy on a vanilla and cream notes with spice and caramel serving as the backdrop. In the sip we found more flavor mingling taking place whereby each note played off of another. Spice, caramel, vanilla, slight touches of malt and alcohol are present in 2013 and are all blended together nicely to forming a bold, rich cohesive pumpkin beer.
Though pumpkin beers are not usually thought of when aging is discussed, Pumking has a high enough ABV that it did not totally fall apart with age. We have opened a couple other bottles of pumpkin brews from years past and they did not fare nearly as well as the 2012 bottle of Pumking nor did we expect them too. We would say if you like more of a boozy, warming beer with subtle spice go for an aged version of Pumking. If what you want is a sleazy ale with the familiar pumpkin notes of August, er we mean Fall, done right grab a fresh bottle.
Since most of us don't have time machines or bottles of year old pumpkin beer just hanging around if you'd like to give this experiment a shot grab a bottle and throw it in your basement/cellar/closet/dungeon for a time. Or just wait until Seasonal Sleaze rolls around, by the time Fall actually hits the beer you bought will already be around 3-4 months old anyway. Whatever you do make sue you enjoy it, all hail the Great Pumpkin.


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Top 31 Easy Hints to generate a Terrific Situation Research Research
It is present with be asked to produce an instance study assessment in school, especially if you are a enterprise learner. All students actually feel stressed if they have an instance analysis to compose. It often appears like a big job to always be told to assess a case review and give an alternative. This is particularly so when you use authentic-everyday life scenarios. When you have been given an task that requires someone to create a case evaluation papers, you can be confident it is actually a lot easier that you really think.
The secret is:
You must be arranged right from the start. When you know how you can tactic producing a case investigation, it is possible to write your assessment and still maintain your sanity plus your decent level. You must examine your instance review and do your homework before you write your assessment. Nevertheless, initially, you must learn what an research associated with a situation review includes.
The situation review investigation
A case review assessment is actually a normal task in operation control training courses. The objective of the work will be to present university students the best way to assess a predicament, evaluate what issues occur, and produce the perfect method to obtain the preferred result. In a circumstance analysis analysis, you can expect to:
- Review an actual-everyday life condition, which can be typically a situation which has been dealt with by the true company
- Make a decision what you want the end result with the condition to generally be
- Recognize concerns that will get a new result
- Establish possible strategies to the issues one has recognized
- Create a plan to execute the top solutions
We will talk about these techniques in more detail, starting with reading through the way it is review and getting ready to write the evaluation!
The way to get ready for your investigation
Your professor may provide you a variety of situation review illustrations to choose from or he or she will just assign that you simply selected circumstance review. No matter how you are assigned the case research, to do an in depth event research details evaluation, you will need to first see the case study. This may appear to be totally obvious, but it is amazing the quantity of pupils that don't take ample time and energy to complete this a part of the course of action.
If you see the instance examine, you must be incredibly extensive. Browse it and reread it. Showcase, underline, and flag important information in the situation analysis to make notices to that you can reference later on if you are writing your examination document.
In the event you don't possess a total expertise in the scenario research your professor has allocated, you won't have the ability to execute a correct research than it. In case you utilize a enterprise event examine design template or make reference to a example of your analysis, it won't assistance in case you aren't intimately familiar with your own circumstance analysis.
You will additionally have to carry out study. In relation to researching, you simply must carry out the following:
- Accumulate tough, quantitative info (e.g. 67Per cent on the personnel took part in the assembly)
- Design exploration instruments, for example questionnaires and reviews (this may help with obtaining records)
- Figure out and suggest the top certain, workable choices
You also need to discover ways to assess a case study. After getting look over the truth study, you will need to ascertain the focus from your analysis. You can do this by engaging in these particular:
- Determine the main exploration challenge. (For instance, the decline of brand name personality as being a challenge dealt with by Starbucks.)
- Study the leading root the things that cause the present difficulty. (When and why does Starbucks reduce its product identity? Were there selected variations in the company's technique prior to when the challenge occurred?)
- Establish the main cause-and-result loved ones between several facets. (Think about what could have an impact on Starbucks' company picture. Maybe the inside perspective from the business? Marketing? The design of the shop?)
- Come up with the perfect ways to tackle the condition. (For Starbucks, this could include paying out additional awareness of advertising campaigns, reconsider the sight and objective phrases, and enhance the appearance of merchants.)
- Write a report or communicate your location for the duration of school conversation
Review your preferred strategies to the solutions delivered by professionals with assessed the way it is review that you were presented. Chances are the experienced methods are certainly more sophisticated than yours simply because these people are definitely more encountered. On the other hand, you should not be disheartened when you failed to arrive at related findings. The whole of the reason for achieving this analysis is always to discover. Use the opportunity to learn from the precious connection with others as well as your success will be far better the next time.
In case you are however unsure, and the offer a excellent information of methods to assess a case review.
Evaluation of material
Producing an instance review could be an extremely complex activity due to the fact you really positive every related facts are provided. Because of this , you might have been asked to look at the scenario investigation extensively ahead of plunging into your examination.
Let's be realistic:
Had you been already an element of the business community and you simply ended up offering an research associated with a true-daily life instance analysis, you would probably struggle to skip an individual details of the info. If anything is ignored, it may spell money and appropriate devastation for any firm in real life. This is the time to search that mastering shape to get it correct, when you find yourself nevertheless students, and a mistake signifies getting rid of a couple of signifies, instead of shedding your job. When it comes to details which can be commonly found in a case study, these use:
- Background information of a particular enterprise, firm, company, individual, as well as other appropriate individual or enterprise.
- An accurate and exact outline from the problem. Remember that your event review have to assist the audience recognize and get pleasure from the tests that need to be defeat.
- Visual supports, including charts, diagrams, and tables, which will help your reader greater comprehend the quantitative records.
- Questions and prompts that assist the reader assess the specific situation bestessay writingservice.
- The list of places that were described while in the study in the investigation.
The concern continues to be:
How would you write the situation investigation assessment papers? You have your entire information and facts, do you know what troubles you confront and how they may be fixed, and do you know what info ought to be added. The single thing kept would be to get a good understanding of the formatting of an circumstance examine analysis.
Circumstance review assessment file format
When you are finding out how to produce an instance examine research, it is essential to find the formatting of your event research assessment ideal. Understanding the scenario review format is critical for that professor plus the student. Anyone preparing and handing out this kind of assignment must ensure the fact that undergraduate doesn't need to use many additional options. In turn, students have to understand that a properly-written instance investigation delivers all information you need, allowing it to be needless to the reader to travel in another place for data.
If in doubt:
Utilize a sound instance analysis research format, much like the a single delivered by theor the records provided by the .
Regardless if you employ an instance study pieces of paper design, you need to adhere to a clear and concise file format when composing your case examine assessment. There are numerous attainable instance study frameworks accessible, but depending on the taste situation assessment style available from , an instance review should really possess ten areas arranged inside the adhering to format:
- Management Summing up: Generally known as a synopsis, this performs as the introduction to the truth research assessment. The provides examples of fantastic and terrible professional summaries. From the professional overview, you might:
- Describe the reason for the way it is examine you might be inspecting
- Offer a review of the corporation
- Supply a short guide of your issues and concerns in the event study
- Go over the thought you will be making use of from the analysis
- Offer the real key points from the analysis and provide any presumptions made over the examination
- Findings: This is where you provide in more detail the specific complications you uncovered on the situation analysis. Within this portion, you will:
- Existing each individual challenge you may have singled out
- Establish each one dilemma you might have selected is sincerely a concern through providing helping information one has identified within the instance study by talking about way of thinking and exactly what you have learned through your class material
- Separate the part (and following pieces) into subsections
- Conversation: This can be the portion that you sum up each one situation or problem and provide your issue for every single preferred option. Here you will:
- Provide a summary of each problem you possess acknowledged
- Current plausible alternatives for each of the issues, keeping in mind that every issue will almost certainly have multiple possible answer
- Give the advantages and disadvantages of every solution in a manner that is sensible
- Bottom line: This is a breakdown of your investigations and discussion.
- Suggestions: Right here is the section of your analysis where you make your testimonials based upon the research and final thoughts. Right here you are going to:
- Determine which on the alternatives most effective healthy all of the challenges you acknowledged
- Provide an clarification why you select the choice you may have presented as well as how it would appropriately resolve the issue
- Be enticing whenever you compose this section to enable you to push your position home
- You should definitely bring together way of thinking and that which you have learned during your class to assist your advice
- Setup: Within this area, you are going to present information on how to implement the remedies you might have advisable. You will:
- Offer an clarification with the items needs to be carried out, who really should take action, then when the remedy really should be executed
- In any problem that it is applicable, it is best to provide an quote of your price tag in utilizing the perfect solution, along with the financial expense and the price of relation to time
- Work references: Whilst you normally do not require to talk about many outer solutions when composing a case examine examination, you can utilize a couple of. Any time you do, you need to adequately resource these sources, which is frequently completed at one of the most important citation variations, which include APA, MLA, or Harvard. There is certainly plenty of guide when citing references so you can observe these , these , or these .
- Appendices: This can be the part you contain within the finishing of your instance research analysis assuming you have authentic info that you employ throughout the analysis. These information are going to be provided in as charts, graphs, and furniture and they are integrated right here because presenting them during the principal entire body of the examination would be disruptive to your viewer. The along with the provide a wonderful information of appendices when to utilize them.
It is actually obvious that we now have some considerable segments which are contained in a case study examination. You must realise and may include all of these. When you are concluded your first draft, make sure to proofread it, not alone for likely grammar and spelling problems but additionally to make sure you will discover no discrepancies or gaps in the issue.
And do not forget that you can find additional to composing a case investigation examination than figuring out exactly what you need consist of. You should also know what you should stay away from when producing your research.
What to avoid when crafting your investigation
Any time you contend with an instance examine, try to remember that there are some dangers to stop! Be cautious about the subsequent faults:
- Too much use of colloquial terminology (even though it is a research connected with an exact circumstance, it will noise official)
- Deficiency of statistical details (give important records, both in percentages as well as in volumes)
- Mistreatment of details (declare only the most important details, rather than drowning your reader in every basic fact you locate)
- Inconsistency within the approaches you possess utilised (inside a circumstance examine, principle takes on a comparatively tiny element, so that you should produce a particular scenario research investigation methodology)
- Unimportant ways of investigation (It is crucial you style and design your very own instance analysis analysis method in whatsoever type best suits your research, including questionnaires and research)
It really is beneficial to see a very few instances of instance assessment written documents. In the end, a example situation study document can present you with some perspective allowing you to observe how to approach every single aspect of your document.
Scenario analysis investigation case in point
It would be much easier to know how a case investigation analysis works should you have a good example of a company event, plus an instance of a case examine analysis. Take into account the subsequent:
The case in level:
- From the AAA Corp, significant improvements in regards to the staff members happen to be put in place. Several of the staff members have been fired in the pretext of not completing the recently authorized examinations.
- Assess the course of motion decided on to determine if it was acceptable, taking into account the physiological peculiarities of each worker.
The challenges:
- Determining the discharges from your authorized and societal point of view
- Evaluating the opportunity and professionalism and trust of each and every worker
- Creating feasible approaches for each one of the people today required
The methods:
- Developing certain questionnaires
- Receiving the details on the employees out of the man assets team
- Carrying out tests to assess the extent for each employee's temper
The final results
- Determining the total number of the people who were able to get one other work
- Consuming take note from the techniques the latter managed to become successful
- Offering a conclusion and opinions in the event
Fortunately, a example of authored scenario reports are simple to come across. Look into this video for the trial case examine evaluation to the Coca-Cola Firm.
If you wish other instances of an instance analysis analysis, the supplies a number of situation examine publishing samples produced by pupils on the university or college. offers a very good illustration of an instance evaluation.
Writing an instance analysis research can seem incredibly overwhelming, particularly if you have never ever tried it right before. Remember, you can do it provided you consume a system, always keep for the structure described here, and relate to one or more illustration of an examination.
Should you continue to need help crafting an analysis of the circumstance examine, your professor is often open to solution your concerns and stage you inside the ideal route. Also you can get aid with any part of the undertaking coming from a . Just sort out the research and give the creating, produce a harsh draft and get it looked at from a skilled, or thoroughly hands the endeavor off and away to an experienced blogger.
No matter the direction you pick out, you may flip in anything of which you could be very proud!


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Releasing August 4, 2020
There's a reason they call me Wylde and it's not just because it's my last name. I might be one of the newest players on the Arizona Vengeance team, but I'm no stranger to the celebrity that goes along with being a professional hockey player. Whether it's a fan seeking an autograph or a puck bunny looking for more, I've grown used to the attention. But when the beautiful and quirky redhead at the local bookstore doesn't fall for my charms, I realize I'll need to be a lot less Wylde and a lot more Aaron to capture her heart.


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Call +1-877-717-6111 – Useful Tips For Buying A Copier
Every business establishment, whether big or small, needs a copier. Xerox introduced its first fully automated plain paper machine in 1959. Since then, copiers have seen a significant amount of technological development. Modern ones can combine copying, laser printing, scanning and faxing into one machine. You can find digital and analog copiers in the market. […]Read more