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96 N Bokelman Street
Roselle, IL 60172
William Wolski, D.D.S. performs cosmetic dentistry for wealthy adults. Unlike plastic surgery, cosmetic dentistry isn't a major operation. However, the results can be just as dramatic. Come visit Dr. Wolski at Smiles Dental Care in the Roselle, IL area, and see how he can perfect your smile.
Dr. William Wolski at his Roselle dentistry practice is pleased to offer you a free smile analysis if you are 18 years old or older. Our friendly and professional team will make you feel comfortable and welcome.
We'll answer your questions and assess your dental needs to achieve long term oral health. Our goal is to make your visit enjoyable, and to give you the smile you deserve.
William Wolski, D.D.S. is proud to be a popular Roselle area Lumineers® dentist. If you have sensitive teeth and want pain-free dental veneers, we can help.
Our highly trained team has extensive experience with this quick and easy procedure. We'll help you transform from feeling self-conscious to feeling confident about your bright new smile.
Dr. William Wolski at his Roselle area cosmetic dentistry practice offers extensive experience restoring your dental implant crown.
Our dedicated team uses state-of-the-art materials and techniques for stability and longevity. You'll enjoy the comfort and confidence of natural-looking teeth.
For patients who need wisdom tooth removal in the Roselle area, Dr. William Wolski can help. If your wisdom tooth are impacted or need to be extracted, you can trust our highly trained professional team.
Your comfort and long-term oral health are our first concerns. We're committed to providing you with the gentle and skilful care you deserve.
Brasky Feldner & Assoc Ltd
15300 West Ave # 111
Orland Park, IL, 60462-4742
Vizgirda, Paul J D.D.S.
9535 W 144th Pl
Orland Park, IL, 60462-2556
Davenport Dental
10660 W 143rd St
Orland Park, IL, 60462
Davenport Dental
10660 W 143rd St # E1
Orland Park, IL, 60462-1908
getting dentures in Orland Park Illinois
cost of teeth implants Flushing NY
Even though dentures are fabricated from extremely durable materials, they will break, wear out, a tooth will come out, or their fit will change. Then its time for denture repair.
Accidents happen, dogs still like to chew on plates of the dental kind, and trash compacters have never taken kindly to dentures. In fact, it is frequently not a matter of "if," but rather a matter of "when" a denture will become broken, lost, or damaged beyond repair.
One can be assured that a problem will happen when least expected, and immediate, usually important, plans definitely will be altered unless a person is prepared.
A short-term use duplicate denture will bridge the gap while a regular denture is being repaired, renovated, or replaced. Sometimes this type of denture is referred to as an "embarrassment denture" because it helps a person avoid the embarrassment of being without teeth in an emergency or during planned denture maintenance.
While this type of denture may be made at any time from an existing functional denture, it generally is fabricated immediately after a new denture is made. The embarrassment denture is neither as accurate nor as esthetic and durable as the original, but it is adequate and only meant for short-term use. The cost is generally considerably less than the original denture.
Such an interim prosthesis may be relined annually and adjusted in advance to fit the current changing shape of an individual's jaws, and therefore be ready to use at a moment's notice.
However, some individuals choose to have their embarrassment denture relined and adjusted only when they need the short-term denture. Following this latter course means that they will have to wait to wear their interim denture until an appointment can be scheduled with a dentist to complete the reline and any adjustments. But a reline for an embarrassment denture can be done in the dentist's office during a single appointment so a patient may leave with it refitted in the mouth.
In either case, a person would not be without a prosthesis while their regular denture is being worked on.
All dentures need to be periodically relined to accommodate the constant change in shape of a person's jaws. There are also times when the plastic body of a denture needs to be changed due to deterioration, or the entire denture replaced because of wear or poor fit from changing mouth conditions that can no longer be remedied by relining.
While relines can be completed in one appointment office visit, more durable relines may require that a dentist keep a denture for several days. Replacing the plastic body of a denture (called a rebase) takes several days and making a replacement denture takes several weeks.
It becomes easy to see how an embarrassment denture would solve being without one's regular denture for a period of time, even for planned maintenance, while getting on with one's life.
by Joseph J. Massad, D.D.S.
Are you a denture wearer who's afraid to be seen in public because your dentures are unattractive? Do you find yourself eating alone because you can't eat foods your friends eat? Do you carry your false teeth in your pocket? Denture wearers, without knowing it, can become dental "shut-ins." They begin, subtly, to reorient their lifestyles around ill-fitting or loose dentures. When dentures don't look or function properly, some people withdraw from their social lives and suffer depression and diminished self-esteem. Some even become recluses.
One denturist had a patient, a truck driver, who couldn't eat properly with his cheap dentures. At truck stops, he would take his food back to his truck and eat alone. He gave up his only social activity on the road, swapping stories with other drivers over a meal. For two years, he was a prisoner in his own truck. Many people can reverse a situation like this though. When prosthodontics look and feel right, denture problems become a thing of the past and the wearer's whole mental outlook can brighten. Eating gives pleasure and a feeling of security learned from early feeding experiences. It's an important part of most social occasions. When a person controls the quality and quantity of his food, he's able to achieve this sense of security and a feeling of self-esteem.
There's no need to feel unattractive or live in fear of a false teeth faux pas in the company of friends and family. A prosthodontist can help you regain function, comfort, and a natural appearance by denture care and repair, or by just replacing or refitting them. Or, it might just mean using better dentures adhesive. Well-fitting prosthodontics are a small sort of miracle, but one that works wonders for your self-esteem. Don't be a shut-in. Call your dentist, and start smiling again.


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The role of autoimmunity in large-vessel vasculitis in humans remains unclear. We have previously shown that infection of gamma interferon receptor knockout (IFN-γR−/−) mice with gammaherpesvirus 68 (γHV68) results in severe inflammation of the large elastic arteries that is pathologically similar to the lesions observed in Takayasu's arteritis, the nongranulomatous variant of temporal arteritis, and Kawasaki's disease (K. E. Weck et al., Nat. Med. 3:1346–1353, 1997). Here we define the mechanism of damage to the elastic arteries. We show that there is a persistent productive infection of the media of the large elastic vessels. In addition, we demonstrate that persistent virus replication is necessary for chronic arteritis, since antiviral therapy of mice with established disease resulted in increased survival, clearance of viral antigen from the media of the affected vessel, and dramatic amelioration of arteritic lesions. These data argue that ongoing virus replication, rather than autoimmunity, is the cause of γHV68-induced elastic arteritis.
The potential etiologies of human inflammatory vascular diseases can be grouped into three categories: (i) infection mediated, dependent on infection for initiation and maintenance of disease; (ii) infection initiated, but maintained by subsequent induction of autoimmunity; or (iii) unrelated to infection, and therefore induced by autoimmunity or some other undefined factor. A number of animal models have been used to study the relationship between infection and vascular disease (reviewed in reference3). Of these models, murine gammaherpesvirus 68 (γHV68)-induced arteritis has several distinct advantages (30,33). The murine system has well-defined genetics and a manipulable immune system. In addition, γHV68 is amenable to genetic analysis, allowing specific viral genes involved in pathogenic processes to be identified (2, 29). Finally, γHV68 infection consistently results in chronic elastic arteritis within 3 to 6 weeks postinfection, allowing us to accurately predict when disease will occur and affording the opportunity to focus studies over a relatively short time.
Gamma interferon receptor knockout (IFN-γR−/−) mice are very susceptible to γHV68-induced vascular disease. After infection, the elastic arteries develop intense mononuclear inflammation and thickening of the intima and adventitia, with a neutrophilic infiltrate extending into the media and necrosis of smooth muscle cells (38). Viral antigen is detectable in smooth muscle cells of the media weeks to months after visceral infection is cleared to undetectable levels (38). Inflammatory lesions surround areas of medial infection, while uninfected regions do not show pathology (38). Notably, Takayasu's arteritis, the nongranulomatous variant of temporal arteritis, and Kawasaki's disease all exhibit pathology similar to the lesions observed in γHV68-infected IFN-γR−/− mice.
Here, we determine whether ongoing virus infection is required for maintenance of chronic γHV68-induced arteritis. Of the three possible processes for induction and maintenance of arteritis enumerated above, we sought to distinguish between the two possibilities contingent on induction by an infectious agent. In particular, we determined whether the persistent viral antigen detectable in the arteritic media reflected chronic virus replication, and whether ongoing productive infection was required for the maintenance of vascular pathology.
Viruses and tissue culture.γHV68 (WUMS clone [32]) was passaged and assayed as previously described (37). The virus was diluted in low-endotoxin Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% fetal calf serum, 100 U of penicillin/ml, 100 mg of streptomycin/ml, 10 mM HEPES, and 2 mM l-glutamine (complete DMEM) for infection.
Mouse strains.Mice were bred and housed at the Washington University School of Medicine at biosafety level 2 in accordance with all federal government and University policies. Mice were on a pure 129Ev/Sv background. IFN-γR−/− and 129 mice were obtained from Michel Aguet (20).
Infection and analysis of infected mice.Mice were infected intraperitoneally at the age of 5 to 7 weeks with different doses of γHV68 in 0.5 ml of complete DMEM. Organs were titered by plaque assay on NIH 3T12 cells (ATCC CCC 164) (37). Organs for pathology were collected into 10% buffered formalin and embedded in paraffin for sectioning and staining with hematoxylin and eosin (H&E) as previously described (38). Parallel sections were used for immunostaining and DNA in situ hybridization. Slides were read in a blinded fashion by A.J.D. for arteritis and viral antigen staining. Lesion scores were determined by criteria set forth in Table 1. Slides were read blinded by Eric T. Clambey, A.J.D., and H.W.V., and scores were averaged for each specimen. Microscopy pictures were taken on a Zeiss microscope equipped with a Spot camera and Spot software 1.1 (Diagnostics Instruments, Sterling Heights, Mich.) and with Northern Eclipse v2.0 software (Empix Imaging, North Tonawanda, N.Y.).
Immunohistochemistry.Immunohistochemical staining was performed as previously described (38). Briefly, a 1:8,000 dilution of an anti-γHV68 polyclonal rabbit serum, generated by infection of rabbits with γHV68 as previously described (38), was used as the primary antibody. A horseradish peroxidase (HRP)-conjugated donkey anti-rabbit secondary antibody (Jackson ImmunoResearch) was used at 1 μg/ml. Biotin Tyramide Plus (tyramide signal amplification [TSA]; NEN Life Science Products, Boston, Mass.) was used at a 1:1,000 dilution for signal amplification, followed by HRP-conjugated streptavidin (Jackson ImmunoResearch) at 1 μg/ml. HRP activity was localized by a 5-min incubation in DAB/metal solution (Pierce, Rockford, Ill.).
DNA in situ hybridization.In situ hybridization was performed with a biotinylated γHV68-specific probe targeted to the 40-bp BamHI repeat region within the viral genome (probe sequence, biotin-TCCGGGCCCCAGCTCGGGAGGGGGCCGGGGAGGTCGGGGA). A control murine cytomegalovirus (MCMV)-specific probe with a similar G+C content was made (probe sequence, biotin-AGTCAGCCTCCGGGCCGCGCGCCGCGTCCGCGGGAAGGCG). Tissue sections were deparaffinized in xylene, rehydrated through ethanol gradients, and fixed with fresh, chilled 4% paraformaldehyde in phosphate-buffered saline (PBS) for 20 min. Sections were treated with 20 μg of proteinase K/ml in Tris-EDTA (TE) for 15 min at room temperature, then refixed with 4% paraformaldehyde for 5 min. Probes were added to a concentration of 375 fmol/μl in preheated (55°C) hybridization solution (50% formamide, 0.3 M NaCl, 20 mM Tris-HCl [pH 8.0], 5 mM EDTA, 10 mM NaPO4 [pH 8.0], 10% dextran sulfate, 1× Denhardt's solution) plus 100 μg of salmon sperm DNA/ml. The probe solution was put on siliconized coverslips and placed on aortic sections. The edges of the coverslips were sealed with rubber cement. Slides were heated to 90°C for 5 min and then incubated overnight at 42°C. The rubber cement was removed, and slides were washed at 37°C for 15 min each with 5× SSC (1× SSC is 0.15 M NaCl plus 0.015 M sodium citrate), 2× SSC, and 1× SSC, followed by two 5-min PBS washes at room temperature. Slides were then treated with 0.3% H2O2 in PBS for 5 min, washed, and blocked (1% bovine serum albumin [BSA], 0.2% powdered skim milk, 0.3% Triton in PBS) for 30 min. Specific signal was detected using HRP-streptavidin (Jackson ImmunoResearch) at 0.5 μg/ml for 1 h at room temperature, followed by amplification with Biotin Tyramide Plus (NEN Life Sciences) at a 1:1,000 dilution for 5 min. HRP-streptavidin (Jackson ImmunoResearch) at 1 μg/ml was then added for 30 min, and HRP activity was localized by tetramethylbenzidine (Moss Inc., Pasadena, Md.) deposition for 5 min.
Electron microscopy.Tissue was fixed upon death or at sacrifice by perfusion with 3% glutaraldehyde in 0.1 M cacodylate buffer (0.1 M sodium cacodylate in water [pH 7.0], to which 0.54% [wt/vol] dextrose was added). All incubations were carried out at room temperature, unless otherwise noted. Tissue was rinsed in 0.1 M cacodylate buffer for 25 min, stained in 1% (wt/vol) OsO4 (in cacodylate buffer) for 60 min, then washed in 1.0 M cacodylate buffer. It was then placed in 50% ethanol for 25 min, immersed in 3% (wt/vol) uranyl acetate (in water) for 25 min, and then put through an alcohol gradient (75, 95, and 100% ethanol). Tissue was then placed in a BEEM embedding capsule (Electron Microscopy Sciences, Fort Washington, Pa.) and immersed first in a 50:50 mix of Spurr resin (hydrophobic methacrylate resin)–100% ethanol for 2 h and then in 100% Spurr resin for 2 h. The resin was then polymerized at 80°C for 12 h. One-micrometer-thick sections were cut and stained with toluidine blue to evaluate tissue by light microscopy. Ultrathin sections (500 to 700 Å) were cut, placed on 100/200-mesh copper grids, and stained with 0.2% (wt/vol) lead citrate (in distilled water) for 1 to 2 min. Specimens were evaluated with a Philips CM10 electron microscope.
Antiviral therapy.Cidofovir (Vistide; Gilead Sciences, Foster City, Calif.) was diluted in low-endotoxin PBS to 6.25 mg/ml and filter sterilized. Cidofovir was administered subcutaneously in the scruff of the neck at a dose of 25 mg/kg of body weight (80 to 150 μl/mouse) (22). Individual mice were weighed each time prior to injection. To test drug efficacy, SCID mice were infected with 1,000 PFU of γHV68 and treated with cidofovir as indicated in the legend to Fig. 2. Mice were sacrificed 10 days postinfection (p.i.), and spleens were harvested for a plaque assay to determine viral titers. For short- and long-term therapy of IFN-γR−/−mice, mice were given a 2-day loading dose (25 mg/kg subcutaneously, starting on day 24 p.i.) and were then injected every 3rd day with the same dose for 3 weeks. Mice were injected twice a week for the remaining time of therapy. For short-term therapy, mice were treated for 4.5 weeks and were sacrificed 56 or 57 days p.i. For long-term therapy, mice were treated for 8.5 weeks and were sacrificed 84 or 85 days p.i.
Statistical analyses.Data were plotted and statistically analyzed using GraphPad Prism (GraphPad Software, San Diego, Calif.). Statistics on survival data were performed using the Mantel-Haenzel test. Nonparametric analysis of arteritis scores was carried out using a two-tailed Mann-Whitney test. All other results were analyzed with unpaired t tests or chi-square tests.
Chronic replication of γHV68 in the aortic media.Viral antigen, surrounded by intimal and adventitial inflammation, was previously observed in the media of γHV68-induced arteritic lesions in IFN-γR−/− mice months p.i. (38). The ongoing presence of viral antigen in the media of the great elastic arteries could reflect either continued virus replication or failure to clear viral antigen from the media after viral replication had ceased. We distinguished between these possibilities using in situ hybridization to detect the presence of viral DNA and electron microscopy to detect the presence of virions.
DNA in situ hybridization with a γHV68-specific probe detected viral genome in the media of an arteritic lesion from an IFN-γR−/− mouse (Fig.1B). The area positive for viral DNA corresponded to the region containing γHV68 antigen by immunohistochemistry (data not shown). A control G+C-matched probe, specific for a region of the MCMV genome, resulted in no medial staining (Fig. 1C; note that the light blue staining in the lumen represents background staining from the glass slide and was observed with both the γHV68 and MCMV probes). The presence of γHV68 DNA and viral antigen within the media is most consistent with ongoing virus replication in the vessel wall. This was confirmed using electron microscopy of aortic lesions, which revealed abundant extracellular virions, as well as cytoplasmic viral particles, within smooth muscle cells of the arteritic media (Fig. 1D to F). Death of infected cells within the media was noted, consistent with a lytic infection. These data demonstrate ongoing productive infection within smooth muscle cells of the aortic media.
Cidofovir inhibits γHV68 replication in SCID mice.We considered two potential mechanisms for chronic elastic arteritis: (i) virus-induced tissue damage leading to an autoimmune response, the latter being important for maintenance of inflammation or (ii) the inflammatory response being solely dependent on continued virus replication in the vessel wall. To differentiate between these possibilities, we tested whether viral replication was necessary for the maintenance of viral antigen within arteritic lesions, and for the persistence of inflammatory pathology, by treating infected IFN-γR−/− mice with an antiviral drug.
Cidofovir, a nucleoside analog, was used for the antiviral therapy because it has been shown to be more efficacious in blocking γHV68 replication than other antiviral agents (21). To determine an effective dosing schedule, CB.17 SCID mice were infected with 1,000 PFU of γHV68 followed by treatment with different cidofovir regimens using a dose based on a previously published study (21). Mice were sacrificed 10 days postinfection, and virus titers in the spleen were determined (Fig. 2). While spleens from untreated mice had ∼107 PFU of virus, mice treated with a 2-day loading dose of cidofovir (administered on days 1 and 2 postinfection) had no detectable virus in the spleen (Fig. 2; limit of detection, 50 PFU/organ). One of four mice treated with the 2-day loading dose and then given additional doses every 4th day had detectable virus in the spleen (500 PFU/spleen), while the other three mice did not have detectable virus in the spleen (Fig. 2; mice with no detectable virus in the spleen were assigned a value of 50 PFU based on the limit of detection of the plaque assay). Overall, only 1 out of a total of 15 mice receiving cidofovir had detectable virus in the spleen compared to 4 of 4 untreated control mice.
Decreased mortality of γHV68-infected IFN-γR−/−mice treated with cidofovir.Based on the efficacy of cidofovir treatment in SCID mice, we designed a regimen for treatment of chronically γHV68 infected IFN-γR−/− mice (see Materials and Methods). We did not initiate cidofovir treatment until 24 days postinfection, at which time acute infection has resolved in the spleen and lung (7, 26, 38). In addition, when a cohort of IFN-γR−/− mice were sacrificed 24 days postinfection, 83% (15 of 18) had arteritis. Thus, the effect of therapy on established arteritic lesions was assessed in these experiments.
In two experiments, mice were sacrificed after 4.5 weeks of cidofovir therapy, while in two other experiments, therapy was continued for 8.5 weeks. Across four experiments using 77 mice (21 PBS-treated control mice and 56 cidofovir-treated mice), cidofovir treatment significantly improved survival (P = 0.0003). This effect was most prominent after prolonged therapy. For the first 10 days of therapy, there was no difference between the survival curves of PBS- and drug-treated mice, consistent with the fact that arterial pathology was established prior to initiating drug therapy. After 4.5 weeks of antiviral therapy, the difference in survival between PBS- and cidofovir-treated mice was not significant (P = 0.08 for data pooled from all four experiments) (Fig.3). Thus, cidofovir protects against virus-induced mortality, but this requires prolonged therapy.
Antiviral therapy diminishes the severity of chronic γHV68-induced arteritis.Cidofovir therapy resulted in significant changes in arteritic lesions. The presence of viral antigen was assessed by immunohistochemistry, and the severity of the inflammatory lesions was scored based on the nature and extent of mononuclear and neutrophilic infiltrates detected by H&E histology (Fig. 5; see Table 1 for scoring criteria and Fig. 4 for representative lesions). While 19 of 19 PBS-treated mice had viral antigen in their lesions, only 6 of 14 cidofovir-treated mice sacrificed after 4.5 weeks of therapy had detectable viral antigen in their lesions (P = 0.0002) (Fig. 5). Notably, cidofovir treatment resulted in a significant decrease in the number of lesions with viral antigen at a time when no statistically significant difference in survival between control and treated animals was seen. Similarly, after 8.5 weeks of cidofovir therapy, viral antigen was detectable in only 4 of 18 lesions from cidofovir-treated mice (P < 0.0001 compared to PBS controls) (Fig. 5). Thus, cidofovir treatment resulted in clearance of viral antigen.
Minimal differences in pathology were seen between lesions from cidofovir-treated mice that still had viral antigen (average lesion score, 4.2 ± 0.1; Fig. 5, columns 2 and 4 combined) and lesions from PBS-treated mice (average lesion score, 4.9 ± 0.1; Fig. 5, column 1). In contrast, lesions from cidofovir-treated mice that had no detectable viral antigen showed improvement. After 4.5 weeks of therapy, lesions without γHV68 antigen lacked neutrophilic infiltrates, although they still had pronounced intimal and adventitial infiltrates (average lesion score, 2.4 ± 0.4; Fig.5, column 3; P < 0.0001 compared to PBS-treated mice). After prolonged therapy (8.5 weeks), lesions without viral antigen demonstrated dramatic improvement (average lesion score, 1.5 ± 0.1; Fig. 5, column 5; P < 0.0001 compared to PBS-treated mice, P = 0.01 compared to lesions without detectable viral antigen after 4.5 weeks of cidofovir therapy). After prolonged therapy the intimal lesions, in particular, had few inflammatory cells and there was only mild intimal and/or adventitial thickening (Fig. 4C, 4D). Thus, antiviral therapy initiated after the establishment of disease resulted in clearance of viral antigen. Subsequent to antigen clearance, the neutrophilic infiltrates resolved and, with time, the intimal and adventitial mononuclear inflammation also improved significantly.
Here we demonstrate that persistence of γHV68 replication in the walls of the large elastic arteries is required for the maintenance of arteritis. The dramatic amelioration of γHV68-induced lesions with antiviral therapy demonstrates that if autoimmunity was induced during this vascular disease, it was not sufficient for maintaining the inflammation once viral replication was inhibited. This result is consistent with the previous observation that inflammation did not extend to uninfected regions of the aorta and pulmonary artery (38). This was particularly evident in skip lesions, where there was a normal uninfected region flanked by two areas of arteritis; inflammation was restricted to regions of the vessel where viral antigen was present (38). If autoimmunity was sufficient for disease, one would expect that infiltrates would not be restricted to infected areas.
For viral infection to induce autoimmunity, the antiviral immune response would have to lead to recognition of self antigens distinct from viral antigens. This could occur via molecular mimicry or epitope spreading (reviewed in references 6 and14). Epitope spreading has been well demonstrated in Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) (reviewed in reference 31). After infection of the brain and an initial antiviral immune response, T cells specific for several epitopes within myelin are activated and are thought to be responsible for chronic disease (reviewed in reference31). These T cells have been shown to mediate cytotoxicity, since they demyelinate organotypic cultures in vitro (4). Thus, viral infection can lead to organ-specific autoimmunity, which could potentially occur in vascular disease as well. The potential for epitope spreading existed in γHV68-induced arteritis, since extensive cell death within lesions was noted by electron microscopy. Smooth muscle cell antigens could be processed and presented by local antigen-producing cells (APCs) to T cells, thus inducing an anti-self response. However, the efficacy of antiviral therapy argues against this possibility.
It could be argued that infection is necessary for effective presentation of autoantigens by APCs. The need for activating APCs to induce autoimmunity has been observed, for example, in a model of diabetes with transgenic mice expressing a lymphocytic choriomeningitis virus (LCMV) antigen in the pancreatic β-islet cells (23). Infection of these mice with LCMV activates tolerant peripheral CD8+ T cells, inducing infiltration and destruction of the islets, resulting in diabetes (23). However, when the activated cytotoxic T lymphocytes (CTLs) are transferred to uninfected transgenic mice, β cell destruction and disease occur only if costimulation and antigen presentation by APCs was induced experimentally (23, 34; reviewed in reference35). Thus, though self-reactivity was induced in this model, it was dependent either on infection or on immune stimulation, even after the initial CTL activation. With respect to γHV68-induced arteritis, if autoimmunity contributes to the development of lesions, it clearly requires continued viral replication, since inflammation did not spread beyond the limits of infection and the inflammatory infiltrates resolved once viral replication was inhibited.
Although in most mice the arteritic lesions showed significant improvement after cidofovir therapy, several mice still had arteritic lesions with detectable viral antigen and severe disease even after 8.5 weeks of therapy. The presence of severe lesions after 8.5 weeks of antiviral therapy may have resulted from inefficient drug access, the local development of drug-resistant viral mutants, or insufficient time for control and clearance of replicating virus.
It is possible that some human vascular diseases may be caused and maintained by vascular infection. Interestingly, the strongest viral candidates for human vascular disease are those that establish long-term persistent infections, such as hepatitis B and hepatitis C viruses, human cytomegalovirus, Epstein-Barr virus, herpes simplex virus, and human immunodeficiency virus (reviewed in references13, 16, and 22). These viruses have all developed various mechanisms for escaping the immune response, both by affecting antigen presentation and immune effector functions (reviewed in references 1, 8, 10, 24, and27). If infectious agents can be etiologically linked to vasculitis, the data presented here suggest that antimicrobial therapy may help control or eliminate active disease. Evidence for infectious etiologies of atherosclerosis, arteritis, and coronary artery and transplant restenosis have been reported (11, 12; reviewed in references 5, 9,15-19, 22, 28, and 36). Two randomized trials of antibiotic therapy in patients with unstable angina or myocardial infarcts were conducted with the hypothesis thatChlamydia pneumoniae played a role in the clinical manifestations of atherosclerosis (reviewed in reference15). The results demonstrated improved clinical outcomes in antibiotic-treated patients compared to placebo-treated controls, suggesting that infection may indeed be important in chronic pathogenesis or acute thrombosis (reviewed in reference15).
Given the efficacy of antimicrobial therapy in γHV68-induced arteritis, identification of specific pathogens that may be associated with the development of similar human diseases is critical. Takayasu's arteritis, the nongranulomatous variant of temporal arteritis, and Kawasaki's disease all exhibit pathology similar to the lesions observed in γHV68-infected IFN-γR−/− mice. Identification of infectious etiologies may well be complicated by the fact that different agents can cause similar diseases, as seen in mice infected with either γHV68 or MCMV (3, 25). Regardless, any successful antimicrobial treatment of human vasculitides will be dependent on the identification of the specific pathogen(s) involved. The data presented here demonstrate, however, that once a pathogen is identified, it is possible to reverse even severe vessel damage sustained during chronic inflammation.
We thank Gilead Sciences for their generous donation of cidofovir. We thank Ramzi Cotran and Paul Swanson for help with electron microscopy. We also thank members of David Leib's laboratory and members of the Speck and Virgin laboratories for helpful discussions.
This work was supported in part by a research grant from the Monsanto-Searle Biomedical Agreement and by NIH grants CA43143, CA52004, and CA58524 to S.H.S. and CA74730, HL60090, and AI39616 to H.W.V.
- Received 1 June 2000.
- Accepted 11 September 2000.
↵* Corresponding author. Mailing address: Department of Pathology and Immunology, Campus Box 8118, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110. Phone for Herbert W. Virgin: (314) 362-2993. Fax: (314) 362-4096. E-mail: virgin{at}immunology.wustl.edu. Phone for Samuel H. Speck: (314) 362-0367. Fax: (314) 362-4096. E-mail:speck{at}pathology.wustl.edu.
- Copyright © 2000 American Society for Microbiology


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Historied Thought, Constructed World: A Conceptual Primer by Joseph Margolis
By Joseph Margolis
Through using numbered theorems that build an interlocking argument, Margolis rigorously articulates his specific rules within the context of labor via Quine, Davidson, Putnam, Rorty, Derrida, Habermas, and Foucault. The dialogue comprises all of the principal issues of the philosophical culture: from technology to morality, from language to global, from individuals to things, from nature to tradition, from causality to objective, from switch to historical past. What emerges is a controversy opposed to essentialism, person who champions the historicity of inspiration and cultural constructionism.
Read Online or Download Historied Thought, Constructed World: A Conceptual Primer for the Turn of the Millennium PDF
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Extra resources for Historied Thought, Constructed World: A Conceptual Primer for the Turn of the Millennium
Example text
The rest of what has so far been confirmed is, however important, of lesser interest. If we reflect on these two claims only, certain additional, quite powerful theorems fall into place. 1) there is no necessity of any kind for restricting constative discourse to bivalent truth-values. 1) had been false, then, as Aristotle correctly observed, a strong bivalence would have been unavoidable: every well-formed assertion would have had to be, disjunctively, either true or false. One could perhaps have postponed the inevitable—as Dummett attempts to do along so-called intuitionistic lines—by holding that the principle of excluded middle need not (yet) apply to syntactically well-formed statements that cannot (yet) be shown to be decidable, that is, such that determinate procedures for confirming their truth or falsity by finite operations may be explicitly formulated or are at hand.
4) is decidedly provocative. I take that theorem to be a par- ― 69 ― ticularly strategic finding, essential to the radical options of the philosophical currents of the end of our century. 4) from the most conservative sources. 4) is not a trick—and that it accommodates (in a fair way) the persistent philosophical conviction that relativism is incoherent and, at the same time, salvages a pertinent form of relativism that is demonstrably not incoherent. The answer lies in a benign equivocation. There are really two distinct forms of relativism, viewed in "alethic" terms or viewed in terms of the connection between "alethic" and "epistemic" considerations.
17). 19) truth and legitimation are intransparent. [12] Not being able to ensure an extensional treatment of natural language by way of an analysis of truth directly, they construed truth as otiose (disquotationally, as in Quine) or replaced its epistemic function by causal means (by "naturalizing" truth, as I shall say, as Davidson does). These distinctions help to confirm a number of additional findings. " The postmodernists (Rorty, Lyotard) assumed that either truth and legitimation were completely "transparent" or else philosophy should be abandoned, but their judgment is an extravagance, and also a non sequitur .


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Kyrie Irving Impressive In MLK Day Victory vs. Miami
1 year agoBoston Celtics point guard Kyrie Irving finished Monday's 107-99 victory against the Miami Heat with 26 points, 10 assists and a career-high eight steals while also adding a blocked shot in 34 minutes. He finished 11-for-19 from the field, including 2-for-5 from behind three-point line. He has posted six straight games with 22 or more points, and he has bagged 14 triples across the past four outings while dishing out 11.0 assists and 2.5 steals per contest during the four-game span. Irving continues to roll up huge numbers lately, helping the team to a four-game win streak after an ugly three-game slide.
Source: ESPN
Source: ESPN


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This year CineLibri is looking for awesome short movies connected in some way to a literary work.
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We are about to select the most exciting movies and they will be screened during a special ceremony which will take place in Lumiere Cinema in Sofia, Bulgaria. The big winner receives a money prize of 1000 euro.


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Masters double international Rajiva Wijetunge won a Gold medal in the Shot Putt event for those over 60 years at the 33rd Sri Lanka Masters Athletic Open Championship meet conducted at the Sugathdasa Stadium recently.
Rajiva hurled the Shot Putt to a distance of 10.34 metres which was his personal best. He also won a silver medal in the Discus Throw. His performances qualified him for the Asian Masters Athletic Championships to be held at Kuching Sarawak Malaysia in December 2019.
Incidentally Rajiva holds the Royal College under-15 and Mercantile over-55 Shot Putt records.
Rajiva was judged the best athlete over 55 category at both the Masters Sri Lanka and Mercantile meets in 2014 for his performance in the Shot Putt event.


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Little Market
This little market will surely become one of your favorite places to visit in the Paseo Arts District. Swing by to grab our cold brew coffee and you will surely find other local brands to fall in love with. Great wines and local beers are available by the glass as well, need we say more? You can shop & relax in this charming market, all while supporting small businesses in our community.


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Evaluation of two treatment modalities for patients with combination syndrome suffering from narrow anterior maxilla
Autori: Riham O. I. , Tamer O. I.
Background: The success of a single maxillary denture in Combination syndrome relies on the principles of retention, stability and support. Severely resorbedmaxillary edentulous ridges that are narrow and constricted with increased inter ridge space will affect this success.
Subjects and Methods: Ten patients with a Combination syndrome suffering from narrow anterior maxilla and mandibular Kennedy Class I were included in this prospective clinical study. Patients were randomly divided into two groups. Group I received four Xive implants supported and retained complete maxillary overdenture with the anterior maxilla augmented with autogenous bone block chin graft. Group II received four Xive implants supported and retained complete maxillary overdenture with the anterior maxilla augmented with vertical ridge splitting and heterogenous bone fill particles of lyophilized deantigenized animal equine collagen, and biocollagen resorbable membrane.
Results: The results of this study revealed nonsignificant increase in the mean bone height loss after 6, 12 and 18 months follow up period in group I and group II. There was a non-significant difference in the mean bone height loss between group I and group II at different follow up periods.
Conclusions: After one and a half years of implant retained and supported overdenture, clinical and radiographic data demonstrated that implants can be successfully placed in either alveolar ridges augmented with autogenous bone or ridge splitting with Bio-Gen and Biocollagen membrane. Also, this study exhibited peri-implant stability with high survival, healthy peri-implant tissue and the marginal bone ridge values were satisfactory around implants.
Pubblicato su Life Science Journal


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Bonnie L. Heim, 70, of Orwigsburg, passed away Thursday, Oct. 31, at The Orwigsburg Nursing and Rehabilitation Center.
Bonnie was born Dec. 16, 1948, a daughter of the late Joyce (Rupp) and Claude Timmins.
She was a graduate of Blue Mountain High School, and attended Penn State Schuylkill. Bonnie was formerly employed at Boyer's Food Market. She also served for many years as the West Brunswick Township tax collector.
Bonnie is survived by two sons, Roy and Christopher; grandchildren, Mia and Max; two sisters, Susan Tolbard, wife of Barrett, and Joy Shappell, wife of Sterling.
After retiring, Bonnie spent most of her time collecting dolls, traveling and spending time with her grandchildren.
A private graveside was held at Zion's Red Church Cemetery, Orwigsburg.
To send flowers to Bonnie's family, please visit our floral section.


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Recommended Reads....
Rating: 5 out of 5


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Fly from New York to Quito, Ecuador for $412 round-trip on Copa.
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Screened as part of NZIFF 2011
Sleeping Beauty 2011
Julia Leigh, the award-winning Australian author of The Hunter and Disquiet, was mentored by Jane Campion on her filmmaking debut – an unsettling erotic fable selected for Official Competition at the Cannes Film Festival.
"It's a startlingly poised, modern-day fairy tale, a strange marriage of Jane Campion and Lars Von Trier that titillates, terrifies and haunts in equal measure. Emily Browning plays Lucy, a university student who takes up a job as a 'Sleeping Beauty'. The work is very simple: she is driven to a rural mansion, sedated, stripped, and then given over to rich clients who can do (almost) anything they wish with her…. But Lucy is a strange fish; she has a dynamic passivity that leads her to sleep with overweight strangers on the toss of a coin... Her decision to risk her life with strangers seems to be driven as much by curiosity and philosophical stance as it is by money. Browning's performance is utterly fearless, suffused with mystery, cold as ice. Leigh's spare screenplay trusts the audience to fill in the imaginative spaces, and her framing is precise and economical. Fast-rising composer Ben Frost contributes a potent score. What a strange, ensnaring achievement, not least for a first-time feature, Sleeping Beauty is: no male director could have made it." — Sukhdev Sandhu, Daily Telegraph
"Sleeping Beauty isn't a perfect film, but it is, in many ways, near-perfect cinema – a unique story, untellable in any other medium, that resists both easy dismissal and glib praise, sinking into the mind with the ungraspable, all-pervading power of a dream." — James Rocchi, The Playlist


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|10th June 2019, 14:23
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Berg also smacked his head on the door again, so that probs left him half dazed, even tho he said he'd stop doing that after the cut he got last time. He nearly had the same cut again and eventually did gush during the match. You could see Taker contemplating life, he should have quit after that streak loss. Has he had a good match since then? I can't think of any.
|11th June 2019, 11:25
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Last edited by Uranium236; 11th June 2019 at 11:26.
Just before Wrestlemania this year, I bought a $30/3-month WWE Network subscription so I could watch the PPV live rather than torrenting it later like I used to and still do with all UFC events. Just last week I as on the app on my XboxOne watching a collection of clips about the Undertaker, his very first appearances, etc. If you watch those clips of him from the early 90's versus how he moves in the ring today... Yeah. RETIRE. Not because I don't like seeing him. But because you can tell how much pain he's in.
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I had a workshop in the Refugee Youth Service which is located in the emptier part of the camp. It is not allowed to live in that part of the camp so only Refugee Youth Service, School and Christian Church stands there alone accompanied with the field for playing football. You will not find the Jungle on the map, although they could have marked it there. With around 6 000 people it is quite a district! However, because of the security reasons refugees and volunteers helping them rather stay incognito.
My first visit was on Thursday afternoon. I did not have the precise direction but you can be sure that more East you go there are always guys standing around the roads who know where to direct you. So I have asked. Nearer you go, the French family houses change into the industrial complexes, highways with bushes and refugees going along the way up and down. Finally, there are policemen standing with the guns around each exit. I did not loose my speed and slipped between them directly into the jungle. And how is the jungle? Well, tents and small houses/tents built of everything you find, little shops and restaurants serving the national food. They are mainly Afghans, Syrians, Eritreans, and Sudanese living there.
At first, I appeared in the wrong part of the camp where the living area is. Since I came inside, everybody was greeting me, asking where I am from. Some men or even smaller boys were trying to flirt, just like boys do and some were curious what I am bringing inside my trailer. Any humanitarian aid is appreciated and possibly expected if you are coming from outside. When I said it is my home, they seemed to be a bit disappointed. However, they were asking what I am looking for and everybody was looking to help me. One brought me there and the another one over there so finally I got to see "bambino" (that´s what they were saying when I tried to explained that I came to do a workshop for kids = ) Well, the bambinos were teenagers.
I set up my table and notes to explain the basics of pinhole photography, some principles, and calculations and I built the black out tent inside the classroom. Boys understand a little bit of English but there was also translator speaking Dari (which is the kind of the Persian language spoken in Afghanistan) so the run of the lesson was made easier.
The day before the workshop I was collecting rubbish boxes and the beer cans around Calais suitable for pinhole cameras. By the other volunteers who are in the camp longer I was advised to paint the beer cans from outside because of Ramadan as well as I was asked to wear long trousers so I do not offend anybody or not cause an uncomfortable situation.
I think nobody felt uncomfortable. Boys were paying attention although sometimes they were looking at me with a suspicion when I tried to explain that the shoe box can be a camera. They constructed beer cans cameras, a shoe box camera loaded with a photographic paper inside and one matchbox camera using 125ISO Ilford film. The whole Friday they were making cameras and taking pictures and everybody could not wait to see them. I was nervous like anytime before. I did not want to let them down. However, the centre was closing at 8 pm and we had to leave the developing for the next day.
On Saturday it seemed that the boys are not coming. There was a beach trip organised and moreover, it takes some while for them to come as the living area is located farther from the youth centre. Finally, the boys started to gather and we could continue. I was lucky and water I had in the bottle was exactly 20 degrees so I did not need to do any temperature adjustments. When we started to develop the photo papers we got to know that the shoe box camera worked the best. I loaded it again with a paper so they could take more pictures and develop them in the tent straight away! Suddenly, more boys wanted to have the pictures and I think for at least two hours I was just going to the tent loading the camera with a photo paper, going outside to explain how to take the pictures and back inside the tent with three boys to show the developing process! I even had to reject three boys in the end because the centre was closing. But I have to say that it was my luck because from the chemicals and the fact that none of us has a shower so often I started to feel a bit dizzy. Well. my portable darkroom is still only an improvised camping tent!
In the end, the magic happened in the jungle. The biggest satisfaction for me was when I saw their curiosity and wondering about how this could happen. There was one boy, a typical teenager who wants to be cool – I would say – who was not so much into making cameras from the rubbish. However, when he saw the picture appearing in the developer he could not believe. Later on, his fellow came and he was enthusiastically explaining in his native language how the pinhole camera works and encouraging him to try it as well! We got some nice negative photographs developed straight away and also the matchbox film which I still have to scan into the computer. Once it is done I will share it with you.
For now here are the negative and positive versions of the developed photographic papers.
Well, my stop in Calais was finished and I would love to come back one day. Because of the rain I was also postponing my cycle journey and stayed in the house where volunteers from all around the world help to sort out the clothes and food distribution for refugees. It is worth to go if not for a long time, at least for few days. If anybody interested I have the email addresses! Write me or check Calaid-ipedia or Refugee Youth Service.


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Krisztina zoekt: Een Studio/Appartement in Den Haag
- Studio / Appartement
- Min. 34 m2
- Vrouw
- Per direct
We are Krisztina and Nikola, currently living in Hungary and about to move to Netherlands in July this year, hence we are searching for a flat for us.
We are looking for place with one bedroom in Den Haag area, for 2 people and our budget is 800-900EUR incl.
As for rent longevity, we would like first to find place for 3-6 months and if we would like it, we would be more than happy to extend it.
|Algemene informatie:
|Vrouw, 27 jaar


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"Thank you" from Ashley Baxter
This leaflet was spotted by a volunteer
in South Holland and The Deepings
on Saturday, 25 Oct, 2014.
One side says 'thank you' to voters explaining that Ashley Baxter missed out on election by very few votes. It also gives some information about the Town Council
The other side is entirely about the County Council plans to withdraw funding from Deepings library.
It was delivered in Summer 2013.
Promoter and Publisher details
Promoted and Published by and for Ashley Baxter, 11 Kesteven Close, Deeping, PE6 8JW.
The data on this page is available in JSON format. The images of this leaflet should be considered to be in the public domain, in accordance with the Public Domain Dedication.


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♥Les Champs-Élysées- Joe Dassin♥
Tag Archives: France
France II.
1.433 miles in 5 days. 286 miles a day. I never realized how big of a country France is, until my mom and I went a French road trip for 5 days. The five days went by SO FAST, too fast and in the moment I knew it. Some days I would close my eyesContinue reading "France II."
France I.
Hot chocolate, Road signs, The Bay of Biscay, bread, butter, stairs, cheese, rivers, confusing door locks and the Mediterranean Sea. When I think of my trip to France, these are the things I think of. 11 days was too long for my mother but not long enough for me. I wanted to climb more stairs,Continue reading "France I."


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IMPORTANT - REACH US IN THE NEW FORUM 05/04/2017Ladies and gentlemen ATTENTION please:
It's time to move into a new house!
As previously announced, from now on IT WON'T BE POSSIBLE TO CREATE THREADS OR REPLY in the old forums. From now on the old forums will be readable only. If you need to move/copy/migrate any post/material from here, feel free to contact the staff in the new home. We'll be waiting for you in the NEW Forums!
*New features and amazing tools are waiting for you, even more is yet to come in the future.. just like world exploration in BDO leads to new possibilities.
So don't be afraid about changes, click the link above and follow us!
Enjoy and see you on the other side!
WICHTIG: Das Forum ist umgezogen! 05/04/2017Damen und Herren, wir bitten um Eure Aufmerksamkeit, es ist an der Zeit umzuziehen!
Wie wir bereits angekündigt hatten, ist es ab sofort nicht mehr möglich, neue Diskussionen in diesem Forum zu starten. Um Euch Zeit zu geben, laufende Diskussionen abzuschließen, könnt Ihr noch für zwei Wochen in offenen Diskussionen antworten. Danach geht dieses Forum hier in den Ruhestand und das NEUE FORUM übernimmt vollständig.
Das Forum hier bleibt allerdings erhalten und lesbar. Neue und verbesserte Funktionen warten auf Euch im neuen Forum und wir arbeiten bereits an weiteren Erweiterungen.
Wir sehen uns auf der anderen Seite!
https://community.blackdesertonline.com/index.php Update:
Wie angekündigt könen ab sofort in diesem Forum auch keine neuen Beiträge mehr veröffentlicht werden.
IMPORTANT: Le nouveau forum 05/04/2017Aventurières, aventuriers, votre attention s'il vous plaît, il est grand temps de déménager!
Comme nous vous l'avons déjà annoncé précédemment, il n'est désormais plus possible de créer de nouveau sujet ni de répondre aux anciens sur ce bon vieux forum.
Venez visiter le nouveau forum!
De nouvelles fonctionnalités ainsi que de nouveaux outils vous attendent dès à présent et d'autres arriveront prochainement! N'ayez pas peur du changement et rejoignez-nous! Amusez-vous bien et a bientôt dans notre nouveau chez nous
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Majestic Gazelle added a post in a topic Apologies to the new playersI can see this argument in a sense, but let me hear you come up with an alternative. This game is ridiculously gear dependent and the way the game functions heavily benefits highly geared players. For example, if I'm new everything goes pretty smoothly until around 52/53. Then once you get to elrics/sausans it gets competitive from there, and I use the term "competitive" loosely. Because 9/10 times they get decimated by 58+ players who have probably been grinding these spots since there release. So this new player comes back, dies again, and again. and again. Now he's considered to be a "karma griefer" (give me a break) . And sure you could group up, but even then you could EASILY get griefed/killed by players due to the shear gear gap. So the idea that dumping these items is destructive is kind of weak in my opinion, other games do the same thing in different ways to narrow these gaps between players. Most of these "top items" are a drop in the bucket for your average player anyway.
Majestic Gazelle added a post in a topic Nerf Witch and WizardI think the damage is fine to an extent, even though it overshadows all the other classes. I just feel like they have way to much to work with on their toolkit compared to other classes. They seem to be capable of much more in comparison to other classes. So is Wizard OP ? Or do other classes need more to work with? I guess in a way the skillcap comes into mind also. You could argue some other classes could do the same just with more effort.
Majestic Gazelle added a post in a topic Is putting PVP behind a PVE grind wall a good idea?I agree in a way, but before you could lose exp getting PvP'd and it made more sense because pvp happened on a regular basis out in the world. But it changed because the majority of the players weren't into it. Now you have this weird PvEvP thing. BUT there are things in the game for catching up, whether it be the soft cap, free stuff you get for logging in, exp weekends whatever. Everybody eventually hits that RNG wall and people end up meeting them there.
Majestic Gazelle added a post in a topic Nerf Witch and WizardNerfs don't always need to be big, there's a lot of tweaking to be done. You would need to highlight the strengths and weaknesses of every class, and follow up with how these strengths and weaknesses carry over into game play . It's hard to do with different types of PvP and then you also need consider the effects these tweaks will have on PvE. Some classes excel at small scale PvP , some medium, and some large. But Some of these classes are great at all of these, while also being great in PvE aswel. Which to me is where the discrepancy comes into play.
I just also want to add that this sometimes all seems pretty pointless when there is no direct contact with the people who made the game. We don't really get any information or reasoning behind the vision they have for the game. Which I think adds to a lot of peoples frustration, it would be cool to hear about the game devs more but that's a whole other issue in itself.
Majestic Gazelle added a post in a topic Nerf Witch and WizardHaha what on earth? Did I say take the second teleport out of the game? No. I said increase the cool down, by how much? I don't know I'm just spit balling ideas...It would only so its not an easy way out the way it is. Honestly you wouldn't even need to nerf the second teleport if you increase the CD on that channel heal to cut back on the self sustain. Your argument acts as if I said remove it which isn't the case at all, therefore I'm not sure I even fully understand your statement.
Majestic Gazelle added a post in a topic Nerf Witch and WizardI said a nerf on the double teleport, not the teleport its self. And to say it would make the class worthless for grinding and pvp is a little extreme. To put it into comparison it would still probably be the fastest grinding class. And you don't even bring of the fact that they get super armor for most of their abilities to combat them being stationary. They have way to much utility for what they are capable of doing.
Majestic Gazelle added a post in a topic Nerf Witch and WizardI don't think they need a nerf across the board, they just have way to much utility. A longer cd on their double teleport and a longer CD on their channel heal I think would be enough. Maybe minor tweaks on the damage but that would hurt the class to much. I don't know what the vision of the classes are. Is it that wizards are to strong? Or are other classes simply weak in comparison and need buffs. I don't know.
Majestic Gazelle added a post in a topic Least Popular ClassesThat's how I feel, it doesn't really give a good representation of whats actively played just whats on accounts. No way Valkyrie is more popular in game than a warrior. I would argue Witch/Wiz/War would be most popular.
Majestic Gazelle added a post in a topic PVP Is Completely Broken. Admit it.I think the gear discrepancy is pretty obvious, but I guess my only argument would be that its all based around large scale PvP. Sure 1v1 it comes down to gear, but I assume the large scale PvP has some sort of strategy to it because with any guild you have your casuals then you have your 1%ers with mantrain gear . (I haven't participated yet). Once they add that arena tournaments system PvP might get a new light . Assuming that the arena tournament brings everybody to the same level.
Majestic Gazelle added a post in a topic YEBIS posteffectsPerhaps this is just one of the projects they felt was worth presenting? Advertising how you optimized an unoptimized game doesn't really fare well when you are showcasing a game. Maybe there is optimization along with this.
Majestic Gazelle added a post in a topic My Olvia access and +100% buff expired. Can I get a new one?I've heard the same thing, they do not stack.
Majestic Gazelle added a post in a topic why suddenly has black stone armor's price fallen ?DK event / Drop event / Crystal Scroll farming
Majestic Gazelle added a post in a topic Seriously though why is the reward vs punishment for PvP/PK so imbalanced?Honest question, how is anybody new suppose to progress in the game when there's people who've been farming the same areas for months now (sausans/pirates for example) capable of more or less one shotting the new person. Do you just stay at cat fish or what? Like realistically what options are there when there aren't many spots to grind to begin with. Even with the upcoming update I doubt much will change.
Majestic Gazelle added a post in a topic What triggers the start of the 30 days on the returning player server?Honestly those channels can be hit or miss, they are SO packed in all grinding areas. Despite the bonus exp it still can be slower than a normal server just due to the population.
Majestic Gazelle added a post in a topic Can I still use the Winter Rosefinch pets after March 1?That's just when they get removed from the market.


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Song KJ, Lee KB, Song JH (2012) Efficacy of multilevel cervical discectomy and fusion for multilevel cervical spondylotic myelopathy: a minimum 5-year follow-up study. Eur Spine J 21:1551–1557
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Charles, Y.P., Schuller, S., Sfeir, G. et al. Anterior corpectomy and fusion for two adjacent levels of cervical stenosis. Eur Spine J 22, 1443–1445 (2013). https://doi.org/10.1007/s00586-013-2816-3
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- Cervical stenosis
- Spondylotic radiculopathy
- Anterior corpectomy
- Titanium mesh cage
- Cervical decompression and fusion