text:
Annika Hurwitt Schahn, Ph.D
Annika Hurwitt Schahn, Ph.D. is a vibrant and inspiring leader who has worked in the field of Individual and Organizational consulting since 1987. She is Founder and President of Optimal Women's Leadership (OWL), Helping Women Help the World, The Center for Optimal Living, providing Principle-Based Training and Consulting for individuals, couples and organizations, and Awake! Presents, where you can find all of her trainings, seminars and blogs. Her vision is to create a world based on understanding and cooperation rather than the current model of competition, division and strife. She lives in Rockland, ME U.S.A., with her daughter, Rhianna.
Sandra Krot
Sandy's vision is to make the workplace a setting for creative performance as well as the elevation of the human spirit. She is a pioneer in translating a principled understanding of human thought to leadership and organizational effectiveness. She is a graduate of Bates College and the University of New Haven. The early years of her career were dedicated to counseling and human development. She founded and served as Executive Director of one the first principle-based programs in the US located in Tampa, Florida. She played a critical role in the earliest attempts to formulate an understanding of human thought into a working psychology and to train principle-based practitioners as a founding member of the first national faculty. She is certified by the Three Principles Foundation to teach the Three Principles as discovered and taught by Sydney Banks. She has consulted with executives, leadership teams and working groups in several Fortune 100 companies for more than a decade. Sandy shares her life with her partner Peter Remick and together they just finished building their zero-energy home in rural Washington. They get out into the awesome Pacific Northwest wilderness as often as they can sea kayaking, backpacking, and biking.
Cheryl Bond, Ed.D., SPHR
Cheryl's expertise leverages 30 years of learning and organizational development experience with a foundational understanding of the role and nature of thought. For the past 14 years she has worked in various divisions of a 10,000-employee line of business that is part of a global technology solutions enterprise. She partners with senior leadership teams to provide support for talent management, teambuilding, conflict resolution, and executive coaching. Her dissertation describes how leadership training based on the role and nature of thought had a significant positive effect on culture and employee morale. The company was a pioneer in bringing this understanding to the corporate world.
Most recently Cheryl is committed to teaching individuals and teams to be more resilient in the face of change, uncertainty, and ambiguity. She developed a framework of training and development activities based on an understanding of the role and nature of thought to help people ride the waves of change with less personal wear and tear. This is her passion.
Cheryl lives in southern New Hampshire with her husband and two dogs. She loves cycling on the rail trails in New England and hiking in the woods with her dogs.
Leslie Miller, B.S.
Leslie has been a Human Resource Consultant since 1983.
She has been an independent consultant with Life Education Institute from 1983-1985 and with Pransky and Associates from 1990-1997.
Leslie helps people lead happy, successful lives. Her work is based on the work of theosopher, author and teacher Sydney Banks. His work has helped thousands of people find new levels of well-being.
Leslie met Mr. Banks in 1984 and after learning from him she knew she wanted to share with people the unlimited potential for insight and inspiration that resides within every person. She is certified by the Three Principles Foundation to teach the Three Principles as discovered and taught by Sydney Banks.
She loves her work and is so grateful to be able to help people access there own wisdom and common sense and to find life to be a full and rich experience.
Leslie now has a consulting practice in Seattle, Washington teaching people the deeper nature of human experience. She works with teens, adults, couples, families, businesses and conducts seminars. She talks with people on the telephone or in her office offering weekly sessions and 4 day intensive programs.
Leslie has been happily married for 29 years and has two wonderful children age 21 and 25.


text:
(AllHipHop News) A$AP Rocky and his entourage have escaped a return to jail in Sweden after being found guilty of assault.
The 30-year-old musician, real name Rakim Mayers, and two of his friends were locked up on July 2 for their involvement in a street brawl with 19-year-old Mustafa Jafari in Stockholm, Sweden on June 30.
The trio was detained in jail for a month before being released from custody on August 2.
Read more HERE.
Also On 101.1 The Wiz:

subset: commoncrawl


text:
- Abstract
- Full article HTML
- References
In general, immunotherapeutic attempts are far from being considered clinically efficacious4,5. However, despite the low clinical response rate, the fact that some cancer patients do respond to these treatments, indicates their potential and justifies the persistent and large efforts to device more inventive approaches6. This unrestricted effort aims to overcome obstacles continuously placed by newly discovered interrelations between cancer and the immune system. The critical role of innate immunity mechanisms7,8, the acceptance of at least some principles of the Danger Theory9, the yet fully comprehended role of regulatory T cells (Tregs)10 as well as the revision of various steps involved in the development of immunological memory11-13 are some of the aspects that, in a short period of time, propelled major reconsiderations of cancer immunotherapy.
Theoretically, the framework of all the above mentioned efforts remains the same, and is no other than the cancer immunosurveillance theory, initially proposed in the mid '50s by McFarlane Burnet and Lewis Thomas. Despite the fact that the first attempts towards its experimental validation led to contradictory results that contested and abandoned this theory, the coming of knock-out mouse technology resurrected it, in the early '80s. It became undoubtedly evident that the immune system encompasses mechanisms that confront and destroy malignantly transforming cells continuously produced in our body, as a result of the plethora of spontaneous mutations taking place during one's lifetime. It is exactly these mechanisms that immunotherapy attempts to use and enhance in order to achieve tumor destruction. The problem, however, is that tumor cells are capable of developing escape mechanisms enabling deviation from this immune attack rendering inactive any benefit that stems from immunotherapy. The mechanisms by which tumor cells achieve tolerance to, and/or even cause damage to the immune system represent a topical and challenging research area and are also the focus of immunotherapeutic approaches as well14-16.
In this context, recognition of tumor cells by the immune system and the subsequent response against them are fairly comprehensible. Tumor cells produce danger signals and express tumor antigens that are recognized as foreign, resulting in the induction of immune responses14. In contrast, the cancer immunosurveillance theory is least explanatory of the biological events responsible for tumor escape.
It has long been suggested that immune functions during oncogenesis, result in the selection of tumor variants, capable of surviving within an immunologically intact environment, very much like various pathogens. This view was strongly supported by the transplantation of tumors induced in immunocompetent or immunodeficient mice, into mice with an intact or deficient immune system17,18. These experiments demonstrated that tumor immunogenicity, as assessed by the fate of the transplanted tumors, was in direct relation to the functional integrity of the donor immune system19.The genetic instability of cancer cells allows the induction of several alterations with the final consequences being the overcoming of immune effector mechanisms and the shaping of tumor immunogenicity. It is estimated that, only as a result of chromosomal instability, 25-50% of tumor cell alleles can be lost20. Convincing evidence suggests that targets of such damage and loss could, at least, be genes that code for various tumor antigens, elements that participate in the processing and presentation of these antigens to T cells of the host21, or factors that intervene with the IFN-γ receptor signal transduction22.
On the basis of these findings, Robert D. Schreider and team formulated, at the beginning of the decade, a different and more comprehensive theory to relate cancer and the immune system, by introducing the term "cancer immunoediting"23-26. Accordingly, this relation follows an evolutionary course comprised by three steps that eventually lead to carcinogenesis ("the three Es of cancer immunoediting"). The initial step represents the time during which the immune system employs effective immunosurveillance by destroying rapidly transforming cells and impeding the formation of tumors (elimination). During the second step, the cancer cells that begin to prevail are those they have developed the ability to deviate from immune attack (equilibrium). Obviously, the surviving cancer cells develop an immunogenic phenotype mirroring the immunoreactive mechanisms of the host. At some point thereafter, the balance between immunosurveillance and oncogenesis, developed earlier, begins to shift towards oncogenesis. Hence, the process now enters the third step, where by immunosurveillance is not capable anymore in controlling the proliferation of rapidly transforming cells, resulting in their complete domination and the development and clinical manifestation of the tumor (escape).
The core of this theory embraces the concept that the immune system on the one hand protects the body from cancer and on the other it shapes the immunogenicity of these cancers. Bearing in mind that the issue is the development of cancer in immunocompetent individuals, it is extrapolated that immunogenicity of each cancer reflects the fine differences that quite possibly might exist between immunocompetent hosts. Another equally important concept offered by this theory, is that tumor escape mechanisms do not develop during the clinically evident period of the disease but rather they represent the final outcome of a long lasting interrelation between rapidly transforming cells and the immune system, during the second step of the immunoediting process.
It is apparent that the immunoediting theory introduces a completely different perception, not only for the relation between the immune system and cancer, but also for carcinogenesis in general. This conceptualization can radically influence the current approaches and potential future applications of cancer immunotherapy provided, of course, that unequivocal supporting evidence will continue to accumulate. Pragmatically, however, this is not so easy, since the focus of immunotherapeutic efforts will have to move towards the long lasting preclinical phase, during which selection of immunoresistant tumor clones takes place.
At the same time, the immunoediting theory raises several questions with respect to the interrelation between the immune system and cancer. As discussed earlier, the ability of cancer cells to sequentially develop the necessary oncogenetic immunoresistant phenotype (mutator phenotype), stems from their characteristic heterogeneity and genetic instability. What are, however, the evolutionary "presses" exercised by the immune system ("editor") and determine each time how this phenotype will be developed?
All efforts to-date towards the investigation of the interplay between the immune system and cancer as well as all immunotherapeutic approaches, assume an immunocompetent host. Undoubtedly, primary immunodeficiencies cannot constitute a similar investigational framework, since their incidence is far lesser than that of cancer. Accordingly, post-transplantation or experimentally induced immunosupression, despite their decisive contribution in the relevant research areas, are far from being considered as immunological microenvironments equivalent to those within which carcinogenesis naturally evolves.
On the other hand, however, it is well established that the immune system presents with an enhanced structural and functional diversity between individuals as a result of its tremendous internal complexity. Naturally, these do not necessarily develop into clinically evident immunodeficiencies due to the balancing effect of the defensive mechanisms. At the immunogenetic level, for example, a large number of alleles with convincingly decreased expression, rarely lead to overt immunodeficiency, or at least susceptibility to disease of immune origin (i.e. autoimmune)27. Moreover, some of the immunological aberrations that have been detected in cancer, like the reduction of IFN-γ production28 or decreased expression of the T cell ζ chain29, cannot be easily attributed to escape mechanisms or tumor mediated immune actions30. Thus, the emerging question is whether the combined presence of such differences shapes an immune micro-millieu that promotes or affects, differently amongst individuals, cancer cell immunoediting.
Theoretically, the above hypothesis could be tested utilizing quantitative approaches (i.e. immunogenomic). The immune micro-millieu, however, is extremely dynamic not only at the phenotypic level. The immune gene expression is under the control of numerous nuclear events, such as the epigenetic, amongst many others31-33. These, in turn, undergo themselves various alterations under unidentified as yet external situations. Therefore, it could be extrapolated that the immune microenvironment, within which immunoediting is taking place, is in fact much more inconstant than indicated even by its enormous genomic complexity.
Should the above reflections focus on the possible epigenetic alterations of immune genes, the question posed is "do cancer cells have the ability to induce them?" and, if affirmative, "from what stage of carcinogenesis?" In other words, "is immunoediting a one way path that carcinogenic processes must imperatively follow, or is it about a bidirectional relation that initiates long before tumor escape immune mechanisms can be detected?"
This question becomes particularly important if the following are taken into account. First, DNA-methylation is decisively implicated in the ontogeny of many immune response processes, such as the HLA antigen expression, the maturation and differentiation of T cells as well as TcR rearrangement31-33. Secondly, dramatic alterations of DNA-methylation are detected in cancer that could account for its etiology but their origin is unclear34-37. Thus, why should these alterations be restricted to cancer cells or related genes and not to other cells, including those of the immune system, as a result of a more generalized/systemic damage imposed by common causes?
There are very few reports indicating that, in cancer patients, peripheral lymphocytes appear with aberrant promoter methylations of their cancer related genes, e.g. the p53 in lung cancer38,39. Moreover, it has been observed in experimental animals, that a methylation-dependent progressive reduction of Fas expression exists in tumor antigen specific cytolytic T cells40.
A broader reasoning of the above question would have to consider the relation between cancer, autoimmunity and ageing. Autoreactive responses not only against tumor antigens but also against normal nuclear and cytoplasmic antigens are frequently detected in cancer41. Despite these responses being considered as secondary outcomes, there is absence of conclusive supporting evidence42. On the other hand it is well documented that the incidence of both viral and non viral tumors is increased among patients with autoimmune diseases43,44. In parallel, recent accumulating evidence indicates that epigenetic alterations of certain immune genes (e.g. CD11a/CD18) are implicated in the pathogenesis of autoimmune diseases45,46. Henceforth, by combining these data it is intriguing to postulate that cancer could be accompanied by DNA methylation alterations of immune genes which are unexplored as yet. The definitive justification of this postulation is the fact that cancer and autoimmunity represent the morbidity phenotype of ageing and immunosenescense, conditions that have also been linked with epigenetic alterations of genes implicated either in carcinogenesis (e.g. estrogen receptor gene, IGF2, etc.) or in the immune response47,48.
Beyond any doubt the experimental formulation of this opinion would require an in-depth reorientation of current cancer research approaches. In the event that such contemporary supporting evidence is gathered, many of the torturous aspects about cancer, in general, would be reconsidered. For example, certain forms of cancer (e.g. myelodysplastic syndrome) respond satisfactory to cyclosporine Α49,50. The question, however, remains as to whether this is a result of the immunosuppressive action of the drug, or the inhibition of the hepatic metabolism of the concomitantly given cytotoxics, or whether it is by-passing the expression of multidrug resistance genes51. Moreover, the recent introduction of demethylating agents in the therapeutic weaponry against cancer, will most likely be influenced52. Theoretically, the effectiveness of these agents, is based on hypermethylation induced silencing of tumor suppressive genes, which has been assumed as an oncogenetic mechanism. Bearing in mind the non specific effect of demethylating agents, it is questionable whether they induce enhancement of global hypomethylation, being also a methylation aberration characterizing cancer, and, even more, if their demethylating effect could affect or "be extended against" immune genes53.
Furthermore, since several lines of evidence indicate that epigenetics, in general, are implicated in the molecular pathways of environmental carcinogenesis, such as those induced by smoking or alcohol54,55, potential involvement of immune gene epigenetic alterations lends to our postulate an additional dimension. This dimension, in particular, could prove to be more important under the light of the ability of external factors, considered yet as non carcinogenic, to induce DNA-methylation (epimutagens)47,56.
In conclusion, the above presented approach adds to the cancer immunoediting theory, as well as the current perception of the immune system and cancer interrelation. Based on our hypothesis, the immunoresistant cancer cell phenotype is not shaped by the immune system acting as a steady and rigid evolutionary pressure, but as a rather dynamic situation forcing cancer cells towards a, necessary for their survival, adaptation process.
Lung cancer was one of the first cancers where hypermethylation of suppressor oncogenes was observed. A significant number of studies have confirmed that, as with all malignancies, lung cancer is characterized by extensive methylation disturbances of tumor-related genes, such as APC, CDH13, RARβ, FHIT, RASSFIA, p16, p14 and others57,58. Consequently, in lung cancer, according to the above described hypothesis, such a generalized, yet of unknown origin, epigenetic alteration can be extended to immune cells and genes therein.
Warm interest for the particular type of cancer is originating from its relation with smoking and lung inflammatory diseases, and in particular with chronic obstructive pulmonary diseases (COPD). Despite smoking constituting the main risk factor for both diseases59, they are highly associated, beyond what would be expected from smoking alone60,61. Most studies about the role of smoking on DNA methylation, concern cancer related genes and were performed within the context of defining precancerous alterations. Limited studies suggest, however, that smoking causes disturbances of DNA-methylation even in non-cancerous tissues62.
The subject of epigenetic alterations that accompany COPD is much more complicated. Chronic inflammation is associated with increased DNA-methylation of genes that is probably specific for particular types of inflammation63. Accordingly, these alterations lead to aberrations of histone acetylation which, in turn, involves the activation of inflammatory mediators in lung epithelial cells. Moreover, oxidative stress and the mediators of inflammation characterizing COPD promote histone acetylation in the same cells, possibly through MAP-kinase signaling pathways, which perpetuates the inflammatory process64. On the other hand, a series of molecular events that become activated during chronic inflammation, have been incriminated for lung carcinogenesis65.
From the above, it becomes evident that lung cancer represents the convergence of a series of events of different etiology that, through different paths, promote epigenetic alterations. Consequently, in lung cancer, more perhaps than for other forms of cancer, it is likely that these disturbances can be extended to genes that participate in the immune response. This potential immunoepigenetic alteration can contribute to the creation of an exceptionally dynamic framework that configures the immunogenic cancer phenotype. This argument represents a promising aspect for the immunoediting theory and, if verified, it can open new avenues in the hot area of cancer immunotherapeutics, in general.
1. Jemal Α, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A et al. Cancer Statistics, 2005. CA Cancer J Clin 2005; 55:10-30.
2. Pluygers E, Sadowska A, Chyczewski L, Niklinski J, Niklinska W, Chyczewska E. The impact of immune responses on lung cancer and the development of new treatment modalities. Lung Cancer 2001; 34:S71-S77.
3. Maione P, Rossi A, Airoma G, Ferrara C, Castaldo V, Gridelli C. The role of targeted therapy in non-small cell lung cancer. Crit Rev Oncol/Hematol 2004; 51:29-44.
4. Davis ID, Jefford M, Parente P, Cebon J. Rationale approaches to human cancer immunotherapy. J Leuk Biol 2003; 73:3-29.
5. Pardoll D, Allison J. Cancer immunotherapy: breaking the barriers to harvest the crop. Nat Med 2004; 10:887-892.
6. Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines. Nat Med 2004; 10:909-913.
7. Ikeda H, Chamoto K, Tsuji T, Suzuki Y, Wakita D, Takeshima T, Nishimura T. The critical role of type-1 innate and acquired immunity in tumor immunotherapy. Cancer Sci 2004; 95:697-703.
8. Palucka AK, Laupeze B, Aspord C, Saito H, Jego G, Fay J et al. Immunotherapy via dendritic cells. Adv Exp Med Biol 2005; 560:105-114.
9. Fuchs EJ, Matzinger P. Is cancer dangerous to the immune system? Semin Immunol 1996; 8:271-280.
10. Fehervari Z, Sakaguchi S. CD4+ Tregs and immune control. J Clin Invest 2004; 114:1209-1217.
11. Woodland DL, Dutton RW. Heterogeneity of CD4+ and CD8+ T cells. Curr Opin Immunol 2003; 15:336-342.
12. Lanzavecchia A, Sallusto F. Understanding the generation and function of memory T cell subsets. Curr Opin Immunol 17:326-332.
13. Coulie PG, Connerotte T. Human tumor-specific T lymphocytes: does function matter more than number? Curr Opin Immunol 2005; 17:320-325.
14. Smyth MJ, Godfrey DI, Trapani JA. A fresh look at tumor immunosurveillance and immunotherapy. Nat Immunol 2001; 2:293-299.
15. Ochsenbein AF. Principles of tumor immunosurveillance and implications for immunotherapy. Cancer Gene Ther 2002; 9:1043-1055.
16. Pawelec G. Tumour escape: antitumour effectors too much of a good thing? Cancer Immunol Immunother 2004; 53:262-274.
17. Svane IM, Engel AM, Nielsen MB, Ljunggren HG, Rygaard J, Werdelin O. Chemically induced sarcomas from nude mice are more immunogenic than similar sarcomas from congenic normal mice. Eur J Immunol 1996; 26:1844-1850.
18. Engel AM, Svane IM, Rygaard J, Werdelin O. MCA sarcomas induced in scid mice are more immunogenic than MCA sarcomas induced in congenic immunocompetent mice. Scand J Immunol 1997; 45:463-470.
19. Shankaran V, Ikeda H, Bruce AT, White JM, Swanson PE, Old LJ, Schreiber RD. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 2001; 410: 1107-1111.
20. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998; 396:643-649.
21. Rees RC, Mian S. Selective MHC expression in tumours modulates adaptive and innate antitumour responses. Cancer Immunol Immunother 1999; 48:374-381.
22. Smyth MJ. Type I interferon and cancer immunoediting. Nat Immunol 2005; 7:646-648.
23. Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 2002; 3:991-998.
24. Dunn GP, Old LJ, Schreiber RD. The three Es of cancer immunoediting. Annu Rev Immunol 2004; 22:329-360. 25. Dunn GP, Old LJ, Schreiber RD. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 2004; 21:137-148.
26. Schreiber RD. Cancer Vaccines 2004 opening address: The molecular and cellular basis of cancer immunosurveillance and immunoediting. Cancer Immunity 2005; 5(Suppl 1):1-8.
27. Jin P, Wang E. Polymorphism in clinical immunology - From HLA typing to immunogenetic profiling. J Translation Med 2003; 1:8.
28. Caras I, Grigorescu A, Stavaru C, Radu DL, Mogos I, Szegli G, Salageanu A. Evidence for immune defects in breast and lung cancer patients. Cancer Immunol Immunother 2004; 53:1146-1152.
29. Whiteside TL. Down-regulation of ζ-chain expression in T-cells: a biomarker of prognosis in cancer? Cancer Immunol Immunother 2004; 53:865-878.
30. Blanck G. Mutations and regulatory anomalies effecting tumor cell immune functions. Cancer Immunol Immunother 2004; 53:1-16.
31. Teitell M, Richardson B. DNA methylation in the immune system. Clin Immunol 2003; 109:2-5.
32. Fitzpatrick DR, Wilson CB. Methylation and demethylation in the regulation of genes, cells, and responses in the immune system. Clin Immunol 2003; 109:37-45.
33. Reiner SL. Epigenetic control in the immune response. Hum Mol Genet 2005; 14:R41-R46.
34. Feinberg AP, Tycko B. The history of cancer epigenetics. Nat Rev Cancer 2004; 4:143-153.
35. Laird PW. Cancer epigenetics. Hum Mol Genet 2005; 14:R65-R76.
36. Jones PA. Overview of cancer epigenetics. Semin Hematol 2005; 42:S3-S8.
37. Belinsky SA. Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer. Carcinogenesis 2005; 26:1481-1487.
38. Woodson K, Mason J, Choi SW, Hartman T, Tangrea J, Virtamo J et al. Hypomethylation of p53 in peripheral blood DNA is associated with the development of lung cancer. Cancer Epidemiol Biomarkers Prev 2001; 10:69-74.
39. Russo AL, Thiagalingam A, Pan H, Califano J, Cheng KH, Ponte JF et al. Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer. Clin Cancer Res 2005; 11:2466-2470.
40. Walker ΠΡ, Calzascia Τ, Schnuriger V, Chalmers D, Saas P, Dietrich P-Y. Loss of Fas (CD95/APO-1) expression by antigen-specific cytotoxic T cells is reversed by inhibiting DNA methylation. Cell Immunol 2000; 206:51-58.
41. Abu-Shakra M, Buskila D, Ehrenfeld M, Conrad K, Shoenfeld Y. Cancer and autoimmunity: autoimmune and rheumatic features in patients with malignancies. Ann Rheum Dis 2001; 60:433-440.
42. Tan EM, Shi F-D. Relative paradigms between autoantibodies in lupus and autoantibodies in cancer. Clin Exp Immunol 2003; 134:169-177.
43. Leandro MJ, Isenberg DA. Rheumatic diseases and malignancy - is there an association? Scand J Rheumatol 2001; 30:185-188.
44. Ramos-Casals M, Brito-Zerσn P, Lσpez-Soto A, Font J. Systemic autoimmune diseases in elderly patients: Atypical presentation and association with neoplasia. Autoimmun Rev 2004; 3:376-382.
45. Richardson B. DNA methylation and autoimmune disease. Clin Immunol 2003; 109:72-79.
46. Januchowski R, Prokop J, Jagodzinski PP. Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus. J Appl Genet 2004; 45:237-248.
47. Richardson BC. Role of DNA methylation in the regulation of cell function: Autoimmunity, aging and cancer. J Nutr 2002; 132:2401S-2405S.
48. Jiang Y, Bressler J, Beaudet AL. Epigenetics and human diseases. Ann Rev Hum Genet 2004; 5:479-510.
49. Asano Y, Maeda M, Uchida N, Yokoyama T, Osaki K, Shimoda K et al. Immunosuppressive therapy for patients with refractory anemia. Ann Hematol 2001; 80:634-638.
50. Sugimori C, Kaito K, Nakao S. Persistent remission after immunosuppressive therapy of hairy cell leukemia mimicking aplastic anemia: two case reports. Int J Hematol 2003; 77:391-394.
51. Ravandi F, Kantarjian H, Giles F, Cortes J. New agents in acute myeloid leukemia and other myeloid disorders. Cancer 2004; 100:441-454.
52. Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004; 429:457-463.
53. Esteller M. Relevance of DNA methylation in the management of cancer. Lancet Oncol 2003; 4:351-358.
54. Carbone M, Klein G, Gruber J, Wong M. Modern criteria to establish human cancer etiology. Cancer Res 2004; 64:5518-5524.
55. Pφschl G, Stickel F, Wang XD, Seitz HK. Alcohol and cancer: genetic and nutritional aspects. Proc Nutr Soc 2004; 63:65-71.
56. Vercelli D. Genetics, epigenetics, and the environment: Switching, buffering, releasing. J Allergy Clin Immunol 2004; 113:381-386.
57. Minna JD, Fong K, Zφchbauer-Mόller S, Gazdar AF. Molecular pathogenesis of lung cancer and potential translational applications. Cancer J 2002; 8(Suppl. 1):S41-S46.
58. Zφchbauer-Mόller S, Minna JD, Gazdar AF. Aberrant DANN methylation in lung cancer: Biological and clinical implications. Oncologist 2002; 7:451-457.
59. Miller YE. Pathogenesis of lung cancer. 100 year report. Am J Respir Cell Mol Biol 2005; 33:216-223.
60. Tockman MS, Anthonisen NR, Wright EC, Donithan MG. Airways obstruction and the risk of lung cancer. Ann Intern Med 1987; 106:512-518.
61. Islam SS, Schottenfeld D. Declining FEV1 and chronic productive cough in cigarette smokers: a 25-year prospective study of lung cancer incidence in Tecumseh, Michigan. Cancer Epidemiol Biomarkers Prev 1994; 3:289-298.
62. Hammons GJ, Yan Y, Lopatina NG, Jin B, Wise C, Blann EB et al. Increased expression of hepatic DNA methyltransferase in smokers. Cell Biol Toxicol 1999; 15:389-394.
63. Ushijima T, Okochi-Takada E. Aberrant methylations in cancer cells: Where do they come from? Cancer Sci 2005; 96:206-211.
64. Rahman I. Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: Antioxidant therapeutic targets. Curr Drug Targets Inflamm Allergy 2002; 1:291-315.
65. Ballaz S, Mulshine JL. The potential contributions of chronic inflammation to lung carcinogenesis. Clin Lung Cancer 2003; 5:46-62.


text:
Final Analysis: The Untold Story of the Susan Polk Murder Case - Catherine Crier (2007)
Part II. THE INVESTIGATION BEGINS
Chapter 20. BUCKING AUTHORITY
Since her arrest on that October night, Susan was convinced that authorities had targeted her unfairly because of actions she took during her divorce proceedings with Felix. In her mind, the judges were part of a conspiracy and did not want to help her in any way.
"I believe the reason for this animosity is political," Susan wrote in a letter she later sent to the court:
In October 2002, shortly before my husband's death, I sent a letter containing an excerpt from my diary to 7 (seven) judges in Contra Costa County accusing Judge Kolin of taking a bribe in a juvenile case involving one of my sons. There were other political statements in my diary, excerpts, which may have given rise to prejudice. I believe Judge [Laurel] Brady received a copy of this letter.
Judge Kolin was called as a prosecution witness at a bail hearing in 2004. He is a friend of Bud McKenzie, my brother-in-law's attorney, and so testified. Mr. McKenzie, according to Judge Kolin, asked him to help prevent me from getting bail. Judge Dan O'Malley essentially recused himself in October of 2004, stating he had been contacted by a number of De la Salle parents. The Briners, friends of Bud McKenzie with whom my son Gabriel lives, are De la Salle parents. Mr. McKenzie was a De la Salle parent. The O'Malleys are Carondolet parents, the sister school of De la Salle.
It seems apparent that there has been a great amount of discussion and influence among these parties, which has also prejudiced the bench. It should also be noted that De la Salle raised money for my sons following their father's death. The Psychology teacher at De la Salle, Mr. Otterstadt, was a former patient and trainee of my husband. I am informed and believe it to be true that Mr. Otterstadt organized the De la Salle community in relation to my husband's death and the case against me.
Susan went on to describe being "attacked" by an officer of the court in August 2003, the day she attempted to file a Faretta motion—a preliminary step to representing herself. The motion is based on a 1975 decision that permitted a defendant to represent himself in a California murder case.
"I was attacked by Deputy Carin, and my arm was broken by him. He hit my elbow with a 'blackjack,' a metal rod," Susan wrote.
Susan went on to claim that the officer assigned to investigate the incident "appears to be related to Judge [Laurel] Brady's clerk."
"He refused to take my statement, angrily declaring: 'I'm not taking anything from you,' betraying prejudice and animosity," Susan wrote.
"This beating is relevant to the homicide case in that I intend to show that the investigation was tainted, exculpatory evidence including my diary was destroyed by law enforcement officers. Other examples of tampering with evidence exist. The beating was an attempt to silence me. In fact, Deputy Carin said just before he broke my arm, 'I told you not to speak in court,' a major obstacle to a pro per defendant."
Regardless of Susan's conspiracy theories, these early bail hearings made it clear that her contempt for authority in the court of law was a much larger problem, one that would prove highly ineffective if carried into the trial. Any progress she made would be reduced when she lashed out at the judges and their subordinates. Her paranoia became increasingly harmful to her case when coupled with her adamant refusal to obey the will of the court. When faced with the choice between controlling herself and lashing out at the bench, she always chose the latter, ensuring that she received no respect from the judges that controlled her fate.
It was a risky path for anyone to take, but for a woman accused of first-degree murder, it appeared almost suicidal.
More than two years of arguing over Susan's bail status (or lack thereof) did little to improve her situation. Finally, in the fall of 2004, Judge Mary Ann O'Malley conducted a review of Susan's no-bail status. Prosecutor Tom O'Connor called Adam to the stand on September 10 to clarify a letter he wrote to the court with regard to bail for his mother, a letter which had ended with Adam saying that it was right for the court to release Susan.
"You know, I love my mom. She's always known that," Adam said to O'Connor. "I don't think that she's a person who belongs in prison. I don't think she fits into the general public of a prison. However, that being said, I don't think she belongs in the general public right now either."
"And why is that, sir?"
"I think that my mom has psychological issues that need to be dealt with that could be detrimental to other people around her…and herself," Adam said.
"Was it your opinion that prior to what occurred with your father that your mother was delusional?"
"A hundred percent, yeah. I told her every day."
"Did those delusions focus on one individual?"
"No, I guess the focal point of her delusions was obviously my father. But there's always something she's been delusional about for as long as I can remember [that] my father was a double agent for the Israeli intelligence."
This idea of Susan's delusions was the focal point of O'Connor's argument that she should not be allowed out on bail. Focusing on her delusions about Felix's involvement with Israeli intelligence, her belief that the Briners were embezzling her money, and statements she made about the "Jewish Network," O'Connor sought to portray Susan as a woman whose mental state was a risk to those around her.
On cross-examination, Susan's public defender, Jack Funk, an associate of Peter Coleridge, designed his questioning of Adam to convey that Susan's delusions had a singular focus on Felix. Susan's delusional behavior did not make her a threat to the public at large, it made her a threat to Felix. Since he was no longer alive, Susan no longer posed a risk to the public.
"During your lifetime…do you know of any other time in which your mother has attacked or threatened any other person?"
"And do you have any reason to believe that if your mother were released, upon whatever appropriate security, that she would threaten or attack any other person?"
"I believe the only answer I can give to that question is, I don't know. I don't think it's a fair question to ask me because I don't know what happened in the cottage that night…. My honest opinion on my mom is that she is an 80 percent sane and rational person and she's 20 percent delusional, and that 20 percent is completely unpredictable. There's no way for anybody to know what's going to happen next, and that's why I think she needs to be getting help somewhere…. She should not be in prison. She should be getting help somewhere so she can come out and be a fully functional member of society."
Shortly after the hearing in September 2004, Judge O'Malley set bail for Susan at $1,050,000, but Susan's time on the outside was brief. Within seven months of posting the monies, she was back behind bars at the West County Detention Facility for violating the terms of her release.
On October 6, 2004, Adam filed a "wrongful death civil suit" against Susan seeking $1 million dollars in damages in addition to other declaratory relief. Eli Polk and Felix's twin brother, John, who was executor of the Polk estate, were named as codefendants in the suit. Andrew and Jennifer Polk declined to participate in the legal action, according to the court papers.
"As a result of the intentional wrongful death of their father, Plaintiffs Adam and Gabriel suffer damages by way of lost love, care, comfort, and support of their father, in an amount no less than $1 million, to be proven at trial," the suit read.
In addition to monetary compensation, Gabe and Adam were seeking declarations from the court that John Polk be named proper trustee of the Trust and that Susan have "no right, title, or interest in Trust, which may be funded by assets having a net total value of $1 million dollars." Furthermore "'upon conviction of murder or finding of felonious and intentional killing' that Susan have no property right or interest in the Estate of Felix Polk or in any asset enumerated in the 1996 Polk Trust, and that she have no right or interest in Felix's share of any community property asset, including Felix's pension plan and the Orinda residence at 728 Miner Road."
As a condition of her bail, Judge O'Malley set a no contact order forbidding Susan from having any contact with her son Gabriel, Dan and Marjorie Briner, Felix's friend Barry Morris, and family lawyer Bud McKenzie. Despite harsh warnings about the repercussions of contacting any of these individuals, upon learning of the filing, Susan sent a flurry of letters to her sons. Although Gabriel refused to respond to her, Susan sent him twenty-four e-mails during this time. Her actions landed her back in jail at the West County Detention Facility in April 2005 with $5 million bail.
Susan told the court that she was simply responding to the civil suit when she contacted her youngest son via e-mail. In a letter to the court, she railed at Judge O'Malley's April 19 decision to revoke her bail, claiming she had written to Gabriel only after her lawyers, Peter Coleridge and Jack Funk, advised her that the no contact order did not apply to legal correspondence.
"However, I was charged with 24 counts of contempt of court for 24 e-mails to Gabriel and reincarcerated and placed on a no bail hold by Judge Mary Ann O'Malley," Susan complained in the letter.
Susan subsequently fired Peter Coleridge in May 2005, and announced her intent to act as her own counsel. Since her arrest, she had fired all three of her criminal attorneys—William Ousterhadt, Elizabeth Grossman, and now Peter Coleridge—supposedly because of disagreements over the handling of her defense. She had repeatedly refused to entertain an "insanity" defense or one using "battered woman syndrome." She had spent much of her life running from a diagnosis of mental illness and she wasn't about to hide behind such a claim now.
Susan would represent herself pro per. In an interview with the Contra Costa Times in the summer of 2005, she told the newspaper that she was convinced she was not going to get the defense she wanted unless she represented herself. "If I'm going to lose when represented by counsel, I might as well represent myself," she was quoted as saying. "At least I'll give them a fight."
While self-representation is not a good idea for any defendant, in Susan's case it was a particularly bad choice. In Contra Costa County, women who choose to represent themselves are at a severe disadvantage in comparison to their male counterparts. The women who are housed in the West County Detention Facility are not permitted to use the jail's "Male Only" law library, despite many administrative complaints from defendants facing felony charges. This restriction greatly limits the amount of research that they can undertake on their own.
This fact may have played a role in the abrupt change Susan announced in late July 2005 when she asked a judge to appoint Oakland defense attorney, Daniel Horowitz, to her case. Horowitz had gained notoriety as a TV legal analyst during the Scott Peterson murder trial by stationing himself at the courthouse to offer legal commentary to cable stations in need of a sound bite. He soon became a regular on Court TV, providing analysis for the Peterson case and later in the Michael Jackson molestation trial.
Representing Susan Polk at her upcoming murder trial would be another opportunity for the lawyer to grab the media spotlight. While Horowitz had represented more than one dozen defendants in capital murder cases during his two decades as an attorney, the majority of his practice was at the Federal level, involving white-collar crimes such as money laundering and embezzlement.
According to his attorney profile, Horowitz was "a defense attorney with an extensive computer and business background" and 90 percent of his practice was devoted to litigation. Nevertheless, he was anxious to take Susan's case to trial. In August, he asked Judge Thomas Maddock to allow him to bring his cocounsel, Ivan W. Golde, on board for the case. Judge Maddock agreed, under the condition that the county pay only Horowitz's fee.
While Horowitz was lead counsel on the case, it was Ivan who actually persuaded Susan to meet with them. He made the initial contact while visiting a client at the West County Detention Facility where Susan was being held. During their brief conversation, Ivan convinced Susan to sit down with him and his partner, Dan, to discuss her case.
Born and raised in San Francisco's East Bay, Golde followed in his father's footsteps by attending law school and becoming an attorney. Unlike his dad, prominent Alameda County Superior Court Judge Stanley P. Golde, Ivan was not interested in a career on the bench. Instead, he had carved out a niche in the world of professional sports, providing legal counsel to members of the Oakland Raiders Football Club and to baseball great Ricky Henderson. Like Horowitz, Golde enjoyed the media spotlight. According to his web page, he had "done battle with Nancy Grace on Court TV…and has commentated on the Scott Peterson and Michael Jackson high profile cases."
Susan liked Golde. He was easygoing and down-to-earth, and the two shared a common background; both had grown up in Oakland and attended the same high school (although Susan's time there was far more limited than Golde's). During Golde's initial meeting with Susan, however, she had made it clear that she was not interested in being represented by counsel. She reiterated that position during the subsequent meeting with Golde and Horowitz, informing the lawyers she was not likely to change her mind.
Still, she listened intently to their advice during a series of additional meetings.
It is not known what finally led Susan to allow the lawyers to take over her case. Perhaps she was growing concerned about her ability to manage her own defense or maybe she sensed that Horowitz and Golde truly believed in her and were willing to do the work necessary to present the case she desired. Media reports claimed that Susan settled on the Horowitz/Golde team after they agreed to present a straight self-defense case and go easy during their questioning of Susan's youngest son, Gabriel.
Once on board, it was Golde who visited Susan in jail and responded to her countless phone calls. Golde quickly developed a friendship with Susan, but over time even he grew weary of her constant needs. At one point, her demands became so great that Horowitz assigned an office assistant named Valerie Harris, whom he had met at the Scott Peterson trial, to handle Susan's calls. At the Peterson trial, Harris had earned a reputation as something of a trial groupie because of her constant presence in the courtroom. Dan admired her interest in the case and asked her to join the firm.
When Adam Polk learned that his mother had asked Horowitz and Golde to take her case, he admonished the lawyers to be careful.
"The first time I met Dan and Ivan, I told them, 'Listen, in two months, you guys are going to be unemployed,'" Adam later explained. "My mother has, throughout her life, for as long I have known her, exhibited a pattern of warming up to outsiders and then completely turning on them.
"I have experienced it my whole life. She is a lady who values control and when somebody else maintains control over her life, I believe she contrives fantasies. Rather than use the word 'delusion,' I like to use 'contrives fantasies' to gain control of the other people [outsiders]."
In spite of Adam's warning, the two attorneys forged ahead with their defense of Susan. In September 2005, Dan Horowitz and Ivan Golde filed a motion on her behalf, claiming Susan was the victim of legal maneuvering that was tantamount to bribery and extortion in connection with the civil suit. Horowitz claimed that Bud Mackenzie, the lawyer representing the Polk estate, was trying to put a "squeeze play" on Susan—raising the possibility that the Orinda house would go into foreclosure if she didn't act. However, when Golde went back to the attorney and offered to put up his own money to halt the pending foreclosure proceeding, Mackenzie reportedly said the house was not in danger.
The motion alleged that Adam Polk was aware that the Miner Road house was not at risk but wanted his mother to believe it was in order to push her to settle. It also claimed that Susan had received veiled threats from an unnamed party that Adam and Gabriel would "testify with great anger and fear about the financial 'situation'" if she did not agree to settle the suit.
While that motion as well as several others that the Horowitz/Golde team filed were denied, the civil suit was settled shortly thereafter, presumably in hopes that Adam and Gabe would be more friendly to the defense on the witness stand during the criminal case.
With the civil trial moving along, Horowitz and Golde began to hone their strategy for the murder trial. They publicly declared they could win Susan an acquittal at trial. Horowitz told ABC's Good Morning America that he had no intention of presenting an insanity defense or a battered woman/burning bed syndrome. Susan was a woman who was abused regularly by her therapist husband, and she truly believed Felix intended to kill her the night the two argued in the couple's guest cottage, the lawyer maintained. Dan Horowitz would argue a straight self-defense case on Susan's behalf—or at least that's what he intended to do.


text:
In the past few years, Google has released the first developer preview for the next version of Android around February or March. With the final release coming around August or September (a few months before the Pixel smartphones are announced and available). It appears, at least according to Evleaks, that the first developer preview for Android P is targeting a mid-March release. That would still mean that there could be two developer previews released before Google I/O in early May.
Google typically releases around five or six developer previews for new versions of Android. This helps the Android team get all of the bugs fixed, but also helps developers get their apps ready for the next version of Android, and utilize all of the new features and API's that are coming in this next version. Google also doesn't typically announce the official name of the next version of Android until around late summer, just before the last developer preview (with finalized API's) is available. So it'll be referred to as "Android P" for most of the Spring and Summer. Including during the keynote at Google I/O, where Google will go more in-depth with the new version of Android, which is definitely going to be an exciting part of the event for developers.
When the first developer preview for Android P does launch, don't expect to see a ton of features announced with it. Google will announce a handful of newer features, usually the smaller features, with the first preview or two. But it will keep the bigger announcements for Google I/O when it talks about the developer preview (and also launches a newer preview). But as is the case with any new version of Android, everyone's going to be excited to see what Google has been working on for the past year. In fact, there have already been a number of leaks coming out depicting what Google may be including in this next version of Android, which should be Android 9.0, if recent history is anything to go by. So the next version of Android should be seeing a developer preview release fairly soon, in the next week or two.


text: Figure 5From: Molecular mechanisms involved in HIV-1 Tat-mediated induction of IL-6 and IL-8 in astrocytes Involvement of p38 mitogen activated-protein kinase (MAPK) in the induction of IL-6 and IL-8 by HIV-1 Tat. (a-f) SVG astrocytes were transfected with siRNA (scrambled or p38α or p38β or p38γ or p38δ) for 48 hours. Then they are mock-transfected or transfected with plasmid encoding HIV-1 Tat. (a, b) The expression levels of IL-6 and IL-8 at mRNA were determined by real time RT-PCR at 6 hours post transfection. The values represented are normalized to their mock-transfected controls. (c, d) The protein concentrations of IL-6 and IL-8 were determined in the cell culture supernatants at 48 hours post transfection by multiplex cytokine assay. (e) Astrocytes were transfected with p38β siRNA for 48 hours prior to transfection with HIV-1 Tat plasmid. The translocation of p65 is measured 6 hours after transfection. Open bars and closed bars represent cytoplasm and nuclear fractions, respectively. (f) Astrocytes were transfected with p38δ siRNA for 48 hours, followed by transfection with HIV-1 Tat plasmid. The levels of p-c-jun were measured after 6 hours of transfection. A representative Western blot is shown in panels (e) and (f). Each experiment was done at least in triplicate and each bar represents the ± SE of three individual experiments. Statistical analyses was performed by one-way ANOVA and ** denotes P-value of ≤ 0.01.Back to article page


text:
Adult Naughty Searching Looking Woman Asian Man Looking For Beautiful Woman
Any conway are ladies wanna feel special tonight. We will fuck untilled we pboobies lookinv. I am waiting for married women and others who feel sexually neglected for a no strings attached sexual encounter. I am sick of the games.
|Relationship Status:
|Actively looking
|I Am Search Sex Contacts
|Topeka, KS
|Long natural
|Relation Type:
|Horny Grandmas Looking Women That Want Sex
Views: 2307
Since I am 24 I am asking that you be no older than If you me and are older than that ggirls will be ignored.
I also do not date outside of my race. If thats all u want then you can look. Message me if you want to get to know me.
This ad is for real. Women or couples very discreet, super chill vgl guy seeks friends w great benefits Trying to find something new w4m I am looking 22043 girls looking for sex someone who can come over and stay the night at least once a week hopefully.
I really miss having someone to cuddle with and miss waking up in someones arms. Please respond with a picture so I know your real otherwise I will just delete.
I would write more here but I always seem to get flagged. So email me and lets get to know each.
Women prostate massage tampa fl sex Lyndon Vermont 22043 girls looking for sex for older woman with some weight on her I am looking for an older bbw who just wants to have a good time with a good looking lbs and disease free Friendship searching love relationship Looking for friends for mommy and little ones Beautiful mature want love Wheeling Beautiful mature ready flirt Great Falls Montana.
Horny matures wanting xxx dating.Single Site
Local personal ready causal encounters. Married swingers looking video chat rooms.Lowell, Indiana, IN, 46356
Beautiful older ladies looking online dating Colorado Springs. Lonely hookup searching swinger xxx.How To Know If Another Guy Likes You
Let me suck the hairy women out of u. Adult looking nsa Bethel Heights.
Hooker women seeking lonely married wives. Horny women in Thurmont, MD.
Fuck someone tonight I fuck a lot of girls and use a lot of different fuck book apps. Meet N Online dating site Ladies seeking sex tonight VA Pimmit. Abuse Form · Adult seeking sex tonight Brooklyn center Minnesota sexy female looking for the same · Shauna discrete guy for same. Pauletta. girls looking to fuck Horny matures Mature housewives wanting asian swingers Housewives looking for sex girls adult naughty looking to please. Local personal wants sex personals SBF seeking friendship possible relationship .
Weakling Seeks Someone Stronger. Mature couples search sexy chat.Need A Big Hairy Man Tonight


text:
Eliza from Ashburn Age: 29. Exquisite, educated and incredibly sexy, a real woman!
Margie from Ashburn Age: 31. Beautiful, young girl want to try different sex, I can invite.
Ver Comics Porno De Los
Cristal from Ashburn Age: 29. I'll invite a hot man to visit.
Lori from Ashburn Age: 34. Charming, tender and sensual fairy of love with beautiful soft, silk skin is waiting for you.
Marie from Ashburn Age: 22. Hi, everybody. I would like to find a lover and a friend and a desirable man.
Free marge simpson sex porn videos from thumbzilla
Marge Simpson Mature Milf. Bart Simpson Cumshots Foot. Big Tits Hot Milf Lingerie. Bart Bart Simpson Marge. We have the largest library of xxx GIFs on the web. Mothers and daughters orgy. Anal Marge Simpson Milf. Sexy Marge Bunny Babe. View Marge-simpson Pics and every kind of Marge-simpson sex you could want - and it will always be free. Slappyfrog- Milf Party - sexy marge simpson from the simpsons and lois griffin from family guy. Marge Simpson Slutty Mother. Marge riempita di sborra. Marge fa un pompino spettacolare a Bart.
Free Marge-simpson pics! Browse the largest collection of Marge-simpson pics on the web.
Margaret from Ashburn Age: 34. Gentle, affectionate fairy, brighten up your leisure time and give unforgettable pleasure!!!
Description: Free Marge-simpson gifs! Browse the largest collection of Marge-simpson gifs on the web. Cartoon Porn Drawn Porn Felsala. A very sexy big breasted marge simpson. Marge si fa fottere per bene dal custode pazzo della scuola. Cartoon Gif Lois Griffin. This content was pinned from. Marge Simpson Porn Video. Sexy Marge Simpson Cartoon. Hugetits bigass Marge Simpson tied up and on her knees. We can assure you that nobody has more variety of porn content than we do. Marge Simpson nude cartoon porn. Simpson family watching porn. Doggy Style Marge Simpson Toon. Hot Marge Simpson Simpsons. Porn Gif with Marge Simpson giving blowjob in jacuzzi.


text: February 5, 2016 - 11:00 PST I'm itchy, cranky, and my vision has started to fail. FYI: If WebMD has told you that you're living with syphilis get a second opinion ASAP, and GTFO WebMD anyway because it's WebMD. You may just be experiencing a touch of Twitter overload instead, the symptoms are pretty much the same thing. But … Continue reading Dear America


text:
This 2 Stroke portable generator is great for job sites, campgrounds or tail gating. The unit provides 1000 starting / 900 running of clean power [More]
You are viewing a very clean and very nice One owner 2014 Tracker Grizzly 1448 with YAMAHA 25 HP 4 stroke about 20 hours!The boat [More]
Homeon Wheels Smart Battery Box with 60A Fuse Battery Holder/Case ONLY. Battery NOT INCLUDED2 integrated circuit breakers (10 amp for accessory plugs and 60 amp [More]
Ozark Trail 12 Pack Camping Tool Set Olive. Condition is New. Shipped with USPS Priority Mail.
Go fishing in comfort in the Sevylor Tahiti 2-Person Fishing Kayak. The adjustable seat and padded back rest will keep you paddling longer. In rougher [More]
DJI MAVIC PRO 4K Camera Drone with Remote Condition is used but in Excellent condition Please review pictures to see all components and condition of [More]
Be afraid of darkness? Just one lantern can bring you enough brightness to be prepared for darkness, power outage and emergency situation. Bring the lightweight, [More]
Swiss Safe Products has designed the most advanced emergency blanket on the market – meticulously designed to for outdoor enthusiast, the marathon runner or emergency [More]
The following list shows the number of each item for the 2 person kit. In parenthesis will be the number for the 4 person kit [More]
Selling a DJI Spark Fly More Combo. I bought the drone for a specific project and have only flown it twice. Includes drone, controller, two [More]
Powered by 2GoCamp ©2020
Privacy | Terms | About Us
Remember Me
Register | Lost your password?
First Name
Last Name
Sign In | Lost your password?
Username or E-mail
Sign In | Register


text:
Atletico's Simeone praises Real's Valverde for cynical foul
Real become the first side to win the Super Cup since it was turned into a four-team event and transported to Saudi Arabia.
Real Madrid midfielder Federico Valverde earned unlikely praise from Atletico Madrid coach Diego Simeone for a deliberate foul that denied Atletico a late scoring chance and potentially cost them Sunday's Super Cup final.
The final, which Real won 4-1 on penalties, was goalless with five minutes left of extra time when Atletico forward Alvaro Morata raced towards goal with a glorious chance to score.
Real survived the remaining minutes as the game ended 0-0 and they scored all their spot-kicks to become the first side to win the Super Cup since it was turned into a four-team event and transported to Saudi Arabia.
Zinedine Zidane's side survived the final stretch of the game to force penalties and captain Sergio Ramos calmly sent Atletico keeper Jan Oblak the wrong way to convert the decisive fourth spot kick for Real to seal the first trophy of the season.
Real's Dani Carvajal, Rodrygo Goes and Luka Modric also scored in the shootout while Saul Niguez struck the post and Thomas Partey's effort was punched away by Thibaut Courtois in a nightmare start for Atletico, with only Kieran Trippier scoring for them.
Ramos hoisted the Super Cup into the Jeddah sky as Real lifted the trophy for the 11th time. It was a 10th trophy for Real under coach Zidane, their first since the Frenchman returned to the role last March after resigning in 2018. Real midfielder Isco added: "The final came down to the boots of Valverde, he was very intelligent and sacrificed himself for the team."
Valverde meanwhile was named Man of the Match despite - or perhaps because of - his cynical foul. "It was the most important moment of the match because if the play had continued it could possibly have led to a goal," said Simeone, who consoled Valverde as he walked off the pitch following the red card.
"I told him not to worry anyone would have done what he did in his place, he did what he had to do," added the Argentine coach.
Real president Florentino Perez was grateful to the 21-year-old for keeping his side in the match, saying: "Fede avoided a clear scoring opportunity and gave us the chance to stay in the game."
Valverde said he had spoken to Morata after the game and felt some remorse for his actions.
"I apologised to Morata. What I did is not good but it was all I could do. I'm happy to win the trophy but I feel a small sense of regret for that."
Real coach Zinedine Zidane joined Perez in praising Valverde for the selfless act."He did well, it was what he had to do and then he apologised to Morata," said the Frenchman.
Old habits die hard for Juventus
Sarri, whose side raced to a 2-0 lead inside the first 10 minutes,... READ MORE
Pakistan, Bangladesh cricket bosses set to meet...
The PCB had proposed to Bangladesh that it could defer the T20 series READ MORE
Atletico's Simeone praises Real's Valverde for...
Real become the first side to win the Super Cup since it was turned... READ MORE
Aguero will die scoring goals, says Guardiola
He broke the record for the number of goals by a non-English player READ MORE
Sheikh Mohammed enacts new gratuity law in Dubai
The new regime commences on February 1, 2020. READ MORE
Here's the reason behind UAE's record-breaking...
More rain is expected across the country in the coming days. READ MORE
Opinion and Editorial
Cloud seeding or not, let's not make heavy...
Can we attribute the record-breaking rainfall (the highest recorded... READ MORE
Dh25,000 salary needed to hire maid in UAE? Not...
There is a way around for those who don't earn Dh25,000 a month. READ MORE
Snow, freezing rain likely in UAE today, says NCM
11 January 2020
Non-stop rainfall in UAE breaks 24-year record
12 January 2020
Flooded UAE schools closed today, exams postponed
11 January 2020
Crime and Courts
Dubai expat creates fake parking ticket to avoid fee
12 January 2020
Video: Hail, freezing rain hit parts of UAE
12 January 2020
Weather: Fog alert issued in UAE, rain likely today
13 January 2020
Sheikh Mohammed issues new Smart Dubai law
12 January 2020
Nearly 1,900 traffic accidents in Dubai because of rain
12 January 2020
Indian army officer slips in snow near border, reaches Pakistan
13 January 2020
Will insurance cover damages by rain? UAE law firm clarifies
12 January 2020
Dubai airport braces for more flight delays, cancellations
11 January 2020
Legal View
What to do if you have a loan in UAE and you lose your job


text:
Our first strategy was to understand the difficult employee. Nonetheless there can come a time when a more proactive approach is appropriate.
Tackling a troublesome employee can make a big difference to competitiveness, here we look at strategy two…..
Strategy two – the 9 month rule
When I was tutoring HR professionals we formulated a 9-month rule. That is, if an employee had had more than two "unfortunate incidents" in a nine month period then it was time to "consider the employee's position". These professionals had a unilateral view. If employment continued beyond nine months then the likelihood was that new unfortunate incidents would continue to arise indefinitely.
Another HR Manager told me how he had to tighten up on his company's bereavement leave. This was because it included grandparents. Some employees had a remarkable number of grandparents that had passed on.
The nine month rule is most effective for employees who have less than 24 months service. It can be straightforward:
You can usually dismiss the employee although there some important points that it would be wise to watch:
- Check the service is under 24 months (or 23 months and three weeks to be safe). It is continuous service that counts. You may have "inherited" the employee from another business undertaking. In some cases they may have worked for you on a temporary contract first. Both these could be part of continuous service and must not be overlooked.
- Decide (if you have not already done so) the true reason for contemplating dismissal. It could be reliability, a negative attitude or just poor performance. As always it is better if you have cogent evidence to support your reason but, in most cases it is not essential.
- Hold a meeting. This is the point at which you tell the employee you are contemplating dismissing him or her. I recommend you convene this meeting in line with your disciplinary procedure, giving notice, the opportunity of accompaniment and providing any evidence you may have.
- Ask the employee for an explanation and listen. This is really important. What you need to listen for (but not prompt) are reasons that related to a "protected characteristic". The ones most likely to be relevant, risky, and ideally not apply, are:
- Pregnancy
- Disability, including health and mental health
- The health or disability of someone for whom they have to care
- Harassment by others in your employment (or by you!)
- Provided nothing discriminatory applies then you are as safe, as you are ever likely to be, to dismiss the employee. They will have no unfair dismissal rights.
- If something discriminatory does arise then you have to decide whether your true reason for dismissal is completely unrelated to any of these "protected characteristics". If you cannot demonstrate this, then there is a risk and you should follow a full procedure.
- If in doubt it would be wise to follow the same strategy as you would if the employee had 24 months service.
Next month we'll look at the second situation, where the troublesome employee has 2 years (24 months) service.
Malcolm Martin FCIPD
Author Human Resource Practice


text:
Enter your work address to calculate commute times to and from 6804 Esther Dr.
Four Bedroom modern remodel on nice size lot! Highly sought after area. Open concept kitchen/dining/family room w/ beautiful upgrades, new laminate flooring & abundance of natural light. Kitchen w/ custom backsplash, waterfall countertop, gas range, breakfast area & great breakfast bar. Sliding door to large covered patio and private backyard. Master bedroom w/ custom ensuite with lots of space. 2019 exterior paint and front door. Modern finishes, great floor plan, large trees.
|4044638 - Residential
|Contingent - 17 days (122 days total)
|4044638 - Residential
|Pending - Taking Backups - 8 days
|4044638 - Residential
|Price Decrease - 0 days
|$437,000 - $20,000
|4044638 - Residential
|Back On Market - 2 days
|4044638 - Residential
|Expired - 30 days
|Show More (10)
|4044638 - Residential
|Price Decrease - 35 days
|$457,000 - $2,000
|4044638 - Residential
|Price Decrease - 10 days
|$459,000 - $9,000
|4044638 - Residential
|Price Decrease - 13 days
|$468,000 - $21,800
|4044638 - Residential
|Price Decrease - 8 days
|$489,800 - $10,100
|4044638 - Residential
|Sign up now to access all sold information!
Property Listed by: Realty Austin
The information being provided is for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Based on information from the Austin Board of REALTORS® (alternatively, from ACTRIS) from January 18th, 2020 at 12:40pm CST. Neither the Board nor ACTRIS guarantees or is in any way responsible for its accuracy. The Austin Board of REALTORS®, ACTRIS and their affiliates provide the MLS and all content therein "AS IS" and without any warranty, express or implied. Data maintained by the Board or ACTRIS may not reflect all real estate activity in the market. All information provided is deemed reliable but is not guaranteed and should be independently verified.


text:
|log in
|Team info
|Understanding music theory is probably the smartest thing that any musician can provide to himself. In case you have learned to play a musical instrument by ear, then that's a wonderful accomplishment. What is really a musician a complete one is not just through paying attention to the notes (though that alone is a vital the answer to as being a musician); it is usually about being aware is really a certain little bit of music work. Which means a musician have to have a good grasp of the most important aspects of music as a way to truly be a complete musician.
Melody. Melody is among the most basic part of an item of music. Though a melody cannot exist without after a basic scale, a scale by itself may not be familiar with create music, simply because the music would sound too redundant if patterned from the order of scales. Rather, picking notes from within a certain scale and reordering these phones fit some chord progression is the most common method to develop a melody. In a nutshell, a melody may be the end result of the scale. It's the most critical element of making a particular music sound a lot more pleasing. Utilized in addition to rhythmic patterns, dynamics, and harmony, a melody's original effect/purpose can be enhanced.
Scales. A scale is really a group of notes that provides a type of skeletal structure for a part of music. Without a basic expertise in musical scales, a musician will see it hard to compose an item of music due to the fact he/she wouldn't know which notes or chords would fit and complement the whole lot of the song. Expertise in scales strengthens your understanding of basic music theory and is incredibly important in order to develop your ear.
Rhythm. A rhythm is often a pattern or placement of sounds (notes, chords, percussions, etc) inside a musical time. Inside a repetitive beat of 4/4 measure, the rhythm is structured around it and reorganized in line with the composer's preference. Having different patterns of a gang of notes makes your melody sound even more pleasing to the ear, especially if it's conjoined with dynamic varieties of playing including velocity, staccato, or legato variations. You can say that a rhythm is a number of an amount of areas of a beat. Just like how melody comes from scales, the rhythm also emanates from the beat.
Beat. The beat is easily the most basic measurement of a piece of music. It connotes the tempo (speed or pace) of your song or perhaps a musical sequence. A beat is simply the counting of your measure wherein you'd create patterns and grooves within its repetitions. By way of example: A 3/4 measure can be counted as 1-2-3 repetitively before song ends (or when another measurement interjects). Likewise, a 4/4 measure would normally be counted as 1-2-3-4 repetitively too.
Harmony. Harmony is a component of music that enhances sections (or large parts) of an melody. Even though it might be utilized as a contrapuntal compilation of notes (counterpoint), its basic usage is always to heighten a melody's purpose inside a segment of the song. Think of harmony since the added options that come with a motor vehicle. A vehicle can look a great deal cooler as a result of gold reams, gold bumpers, etc. That is what harmony is; it can make a melody sound a great deal cooler. Harmony basically arises from scales and frequently starts as being a contrapuntal 3rd or 5th note to the root note.
Dynamics. Dynamics is basically the volume of how each note is played inside a rhythmic pattern. It is almost always dependent of rhythm but it can also be interjected as being a singular instance that repeats rarely. However, with regards to rhythmic patterns, the same using of the quantity style is often repeated after every other pattern (though that is not absolute). Dynamics also means the type of how each note is played. Staccato (a mode of dynamics) is used to slice short the noise of a communication (or possibly a rhythmic pattern of notes). Legato, another style, is actually used as a way of prolonging notes in order there is no obvious gap between the rhythmic note patterns.
To read more about ungeekit.com please visit webpage: read.
|5 Jul 2019
|Web site
|Total credit
|Recent average credit
|Cross-project stats
|Primary school
|New members in last day
|Total members
|0 (view)
|Active members
|0 (view)
|Members with credit
|0 (view)


text:
A sculptor and photographer whose time-based work often reflects scientific and environmental concerns and reveals an intrinsic bias towards process and event.
A writer and photographer, using these to inform, educate, discuss, and make people think about the world around us and our impact upon it.
An image-maker, curator, and educator working predominantly with photographic-based mediums to explore our precarious relationship to the natural world.
A writer, musician and photographer, with a regular column on climate change, whose novel, New Clone City (2018), features environmental themes in an urban setting.
An artist using photography in its broadest sense – analogue and digital process, natural materials and camera-less methods of image making – to explore our relationship to nature.
An artist who uses photography in a search for illumination, playing out the metaphysical question of just how little light is required to dispel darkness.


text:
15+ word vorlagen brief
Accountants deal with plenty of tasks to keep on keep your organization on track. In the event that you will need a lawyer who's a leader to choose the helm of a finance group that is distressed, you'll certainly require some one with management expertise and abilities. Being being a CFO you are predicted to develop into a skilled accountant or financial analyst who can detect fiscal health and the issues of a small business by going for a look in the total amount. Choosing the appropriate accountant to employ may be hard. Deciding upon an accountant is also an ambitious undertaking. Perhaps your dad's accountant demands a website. While you are writing a bookkeeping restart, write it with an advertising flare.
Everybody's encounter and condition disagrees. Any expertise in various domain like legal or accounting should have the ability to help you do the job more rapidly and far much more precise and get a superior grasp of these records. Perform is generally repetitive after you learn how the approaches, but you'll find plenty of different tasks that should really be done following strict guidelines and producing important documents. You might wish to make your resume relevant to just about every single job. While the occupation may entail cash or perhaps even a larger name, you have to show up and do this job each daily. there's no need to repeat it your restart contains your speech. Where you may discover several content and suggestions if you would want to get more information regarding writing resumes that get interviews, then goto a blog such as for example Top Career Resumes.
Perhaps not many clients are conversant with items, and that means describe risks and the duties on the exact long run, so to be sure they're able to sustain it and you want to spell the costs and advantages of each. Basically, find out where your clients go there and acquire their information online. Small business acumen a company banker's customers are entrepreneurs or modest business owners, searching fund raising or to nurture their own organizations. Last, make certain that your application actually mentions the conference that is suitable. A superb app for students travel ban should consist that you just be based to be able to attend the seminar. Most organization processes need an outstanding deal of support also to be able to decrease costs a number of those tasks have been bundled in jobs such as assisting staff and also to use. Like whether it's a research or development endeavor, then that's a terrific skill to get In the event that you simply have just one endeavor.
The restart service is still support. In case the consumer will make statements that are odd as being a designer or programmer you will need to bring some vagueness in your own skill. At the instance of a makeup retailer, for producing a referral, clients may like to acquire a sample or product. For instance, you can opt to mail a buyer, tweet them or whatever the up coming brand new concern is. You can find a lot of strategies to reward your customers and their referrals be certain whatever it is, fits your own company.
If you are a developer, then you may start a small business totally free of money offering your programming abilities. Take a good peek at our firm preparation guidebook to discover much additional, Once you are all set to get started planning your new business, or check out LivePlan, our small business planning pc software! Without the company of shoppers, a company may not be able stay active and also afloat. Its not all business needs to employ a full size accountant. Whether you run a advertising company or some small, regional company, you are able to learn from Ritika.
Seek aid out of a good companion or a man or woman who's much better than you personally in expressing or writing exactly what you'd love to say, In the event you discover it rather tricky to write an objective for yourself. Quite basically, your goal is always to be employed. A well presented objective may be the high-impact tool which may come across a potential employer's focus . Another characteristic of the storeman's project is to ensure that the security and security of the inventory exchange.
A example of efficiency may function as selection of emails processed similar or daily documents. No matter, you are still able to pay back your price tag that is whole. Recognizing the legitimate difficulty or company need (Business need ) can create certain you're bringing the most value to your client. The charge to displace an employee is roughly double their annual salary, which is a excellent purpose in-and-of itself to make certain you discover the acceptable accountant the 1st time around. Some of the advantages to be a VA is that you do not need to clock. Now you understand referral apps and referrals may aid your organization, it's time.
A referral is really a recommendation from somebody else. Referrals are some of the the most essential increase drivers to most apps. The means will be to provide exemplary merchandise and remedies.
The objectives section might be the very best approach to make job resumes that are distinct. Supplies a succinct introduction to the purpose supporting the resume and the form of task which you are looking for. It really is normal for job-seekers to add a brief objectives section at the beginning of their resume The aims department might be the issue employers looks, and can be a significant part of a resume at.
It's expected and also so the letter will likely be placed. The company letter is a formal letter that's six pieces that are specific. When you grasp the 6 aspects of an organization correspondence, writing one is easy and fast. Even with variations of tone and style, the basic elements of a company letter remain normal all through most industry correspondence. It represents a company and a organization. Define in the email address there are replicas because it truly is simpler for your reader to comprehend Once you are emailing the organization correspondence. Formal business letters call for a protocol regardless of what the correspondence's intent.
Give an overview of those points you're going to be creating in your correspondence. Writing an expert correspondence is not some thing that is simple to reach and many men and women will fight to do without making faults. Professional letters are a part of the company world and certainly should definitely come advice play when employing for employment. So it's straightforward to scan at length, format your correspondence. Your employment cover letter ought to become no over one page. Your employment cover letter should be particularly tailored to every project that you employ.
Use bullet points or short key words to generate the letter simpler to see. You should be genuine, when producing suggestion letters. A suggestion letter has to be delivered instantly and may supply the advice to aid the recipient clear up the problem accessible. A article follows a number of guidelines that are standard.
In the event the adhesive will talk into the antenna or defroster traces once that the area is installed, use a foul-smelling adhesive. Implementing a conductive adhesive can affect the functioning of the electrical system. Any mat of paper is going to complete, however design and style , or it you want your spouse to recognize your notes, you may want to receive them the exact color. When there's more than one enclosure, it truly is frequently compulsory to mention replicas at a letter. You also can decide to reference how many enclosures are all comprised if there are enclosures together with the letter. In numerous situations a enclosure can allow for a bigger fan that create noise and will turn slower. Alarm the receiver together, if you should be adding enclosures on your letter.
It wouldn't require any other remedies prior to fabrication After the glass has been made. Though it is made everyday of this year, the raw substances are all inserted as required from batches. When the suitable temperature is reached by the glass, it's molded into shape and cooled. Laminated glass is constructed of 2 components of glass. It is crucial to make windshields inside the usa.
Float glass identifies the glass fabricating approach. The glass has been scrutinized and washed repeatedly throughout the process to make sure it was manufactured to the very optimal/optimally quality specifications. Tempered-glass is one parcel of glass that's strengthened through a cooling system practice. Bullet resistant glass is made for software having a resistance to a selection of bullet calibers.
Start using, In the event you are unsure in case the receiver is male or female. The receivers of these letters could possibly function as some other person who is accountable of employees within an business, administrators, or even the firm proprietors. You receive an invitation. Assuming you're using company letterhead, then your whole speech will be on the page. Any paint or art design is put in the glass if it is at the flat position.
If you are sending a duplicate of the letter into someone else, add on a CC line. If you're enclosing 1 record, then you may opt to merely note that there's an enclosure. When it may occasionally be evident there are additional records in an envelope or attached in a email, it's professional courtesy to comprise things just like the contents of them to your own business letter. It is imperative to understand the structure of the business correspondence, or so it is read by that the recipient takes it badly. Letter templates permit the user give the layman using the verbiage for small business matters and to deliver question or a note in a concise, specialist manner.
Your very best alternative is always to send a enterprise email, if you want to know more about a pressing message to make it instantly . Regardless of the topic matter, a small business email is your required kind of communication, in the event of paperless offices. An organization electronic mail, to the reverse side, additionally is written usually employing a computer system or electronic means, but it is digitally discharged to the recipient in an issue of merely a couple of seconds. The inner address is your purpose where the letter is currently being sent. Remember which in the event you own a post box address in place of the letter and also civic address has been delivered by way of messenger help, the messenger will be unable to deliver it. Sporadically you may have to dig around to detect the exact info that you will require, other occasions.
A university is going to have. The internship resume illustrations sample must be followed to find the outcomes that are ideal. Your resume should be formatted within an specialist way. Resumes have grow to be the ticket for surfing the job marketplace. Take some time to grow your self to the applicant that is probable, and spend the opportunity to make sure your resume is performing the absolute best possible job representing you along with your abilities. Your resume could be around you personally but additionally, it is greatly concerning the secretary. It's not unusual for job seekers to communicate regarding departing the business earth to make use of alternative charities or nonprofits.
In the event that you may sell esoteric merchandise and providers individuals care about, you then should be at a posture. If you're in possession of a Double diploma in Marketing and also Design kind a university that is well-known is far better. Many businesses utilize on the web applications which scans manuals for words. A human services resume has to prove the candidate owns the wisdom necessary to clinic in a setting that is certain or maybe to make use of a certain population. Recognizing that the connection between technology and corporation is to progress in your own career. Communication with ColleaguesConnecting with your coworkers is part of their occupation to uncover task it's a portion of the culture of the organization and their worker encounter.
The HR knowledge of standard Boolean keyword searches to comprehend fantastic resumes can be just really a example of tagging that is emblematic. Knowledge also has a great decision about the tests advocating the remedy and to be done on the patient. You are going to get extensive wisdom and hands-on experience fostering or when acquiring the abilities required for HR pros as well as other leaders. Youstart out and'd better check having an internship encounter. Be happy to accept lateral movements if you should be given the chance, even though you may not be offered some standing or commission improve it can help you develop skills that are new by a move, and that's what counts the absolute most. Along with also an rising amount of contract tasks have been supplied than ones that are long term along with the chance of organizations restructuring, some job seeker retaining a job to get a lifetime's possibilities would be growing far less probable. Take a glance at my top 10 restart errors you may want to avoid.
In the event you've ever wondered whether your occupation has been the best one for you or at case you have to acknowledge a work offer, then there are some aspects that you have to simply take into consideration ahead of making a determination. The occupation of a social worker is one of the professions that individuals've. And it one of the means for applicants to find your 26, A job posting would be the best supply of hires. If you believe your job is however have a tough time with colleagues, consider connecting with them. As soon as you already are utilized Keep in mind, it's more easy to seek out a brand new job. It may be really tricky to learn what the work entails. If you would want to receive work in a renowned provider, get your very best to fulfill their standards also to prove yourself.
Like a guideline, consistently consider employer or the particular recruiter you are planning to get if authoring or structuring your resume. At the event the company is currently skimming resumes, she needs to have the ability to get the advice that is essential without having to examine the resume. Quite a few employees find yourself feeling their present employers find it not possible move to scan the marketplace and to provide the things that they desire. If you should be clear about where you plan to use being a social worker, then it is likely to add the exact same in your career aim. Residential care workers have to become empathetic.
Enforcement expertise A probation officer is prediction to do the job well with community alternatives, judges and NGOsbeing willing and open to accommodate to individuals that are unique is vital. Common and alike essential vital things to remember for every sort of executive resume includes having a modern layout and style, including your contact info that is present, and listing work target heading over the listing department. The advertisements executive is currently hunting for a work, however, was consulting at the interim,. Don't feel that the potential employer will devote time attentively searching for your qualifications. Poor ManagementUnfortunately, amongst all the distinguished managers, there are a range of not so excellent directors. For instance, an experienced manager may think it's clear they understand how to inspire folks, but it really is perhaps maybe not. A business-savvy social networking supervisor knows using social websites from the firm and sees the photo.
Testing is also crucial in virtually any software undertaking. Testing has been done. A tester should have a program and must develop a well-thought-out test strategy and strategy. It ought to have the ability to anticipate complex issues, along with articulating and imagining them. Use skills and testers need to appear together and should learn how to communicate to the stakeholders to steer clear of inconsistencies and ambiguities. Computer software testers should really have the ability to spot and tackle matters and ought to develop a strategy to confirm them. To work, but you require talented applications testers.
The number of decades linked with work information, should be exhibited at the primary line if you should lure the reader's awareness rates. It really is a fact that engineering stipulates that the significant amount of biomedical occupations in the whole world. You can find a growing number of kinds of resumes and some are very beneficial.
You are going to write the very best QC or QA restart they can get. While looking for a place, you might filter out by job seekers in the event that you are currently searching for operate, in the event that you're attempting to find an employee or by company. Using multiple contact procedures along with additionally the touch (not only a section ) of a genuine individual, a work seeker is far more likely to trust the occupation will be valid and apply. It is a fact that engineering stipulates the maximum assortment of bio-medical jobs in the whole world.
A excellent deal of screening tasks have been temp to employ, or only temp. You're likely to be hired beneath a staffing business Almost certainly if you get hired to an testing occupation that you may not be officially working for this firm, or you will have a contract with the organization. As an advertisements record it will do its occupation, past the qualification outline the possible employer reads if, you're more prone to generate the purchase and become referred to as to obtain a labour interview. You can make a bid In the event that you can not monitor a lasting task within the country.
You wish to enlist in the proceedings that you're not a teacher in orientation training when you're accepted to your work. On the reverse side, you can also receive a lucrative job in search to support find methods to extract and refine petroleum. The wages rides on enough period spent and form of work achieved. The most regular salary is for its lower levels.
At the start of one's livelihood, you might not earn a rather large quantity. If you would take pleasure in the career, you likely to eventually become at get paid a special feeling. Where they employer was about the lookout for somebody to update the organization site using graphics however doesn't necessarily are able to accomplish 36, you might try to be eligible for a job. There are a lot of occupations for individuals who have visual-spatial brains.
You should attend orientation training in the event that you are perhaps not a certified instructor In case you're recognized to find work. Consistently find more information concerning the provider that you are employing to and also make sure the sort is something that you need to find out about. In case you would like to find a job in Canada, you may ought to ensure ahead of wanting to receive a work visa, even if you are going to, the standing would have a visa that is long term or momentary. Implementing a work in home job you certainly can certainly do the occupation the business extends for your requirements and you additionally get paid that you do. If you can't track down a job within the world, you may make an attempt to track down a job.
Figuring out the way to compose a resume cover letter is simple which you're searching for. While some familiarity have been inborn, a great deal of them are still in a position. Since there's absolutely no prior work expertise they could emphasize and communicate abouthe would love to target more regarding his talents together with their own capability to acquire fresh abilities as a means to coincide with the targets of the organization. Perks and your salary grow steadily as you obtain experience. In the event of an analyst, be positive lack of experience will not work against you and highlight your own various expertise that'll function to this organization. The experience will be invaluable and one will be hired by another firm afterwards, in case it is possible to can receive one particular occupation for a game tester. You've acquired knowledge relevantto QAthat's exactly what you will need to reveal them, though you don't have a QA encounter.
Recruiters usually attempt to locate the achievements of their candidates. Personal attorneys, to the reverse side, are trained like accounts receivable and billings, in the processing of many accounting arrangements. An individual accountant will have. Generally, private and people accounting are numerous facets of the exact very same field.
In the event that you'd like hints that are thorough on how best to write a cover letter, then I would be delighted to allow you to. There are only a couple more tips you must learn when writing your letter. A fair resume cover letter can do more damage than great therefore be certain your resume cover letter is to work with you to land your interview. Writing an honest report really should not be a uphill task when the process of symbolizing them will be adopted, since it's presumed. Its also the highlights reel which you employ to find the interview. The clinic can help you to tweak any difficulty areas for you.
There continue to be many people that prefer creating the job seeker. The biographies for many deductions of police jobs will be all available in the marketplace. Realtor bio degradable is referred to as real estate . Overwriting is certainly a huge blunder on paper police bio created by men and women. Writing the bio degradable based on more or two pages would be your error. It is going to be better to share your audio biography aside from the bio.
Templates don't need to be dull. If you have got Template Docs enables you to contribute your pleased with an selection to market your goods or services. Sometimes you are going to encounter the very best bill templates on the many sites that are surprising. Additionally, you may possibly customize the chosen templates so they fit your buyer's needs. Therefore it will be quite simple to select from their many templates. You can find 20 totally free Resume templates that you are able to down load out of Resumetemplates.in.
One of the most crucial features of HR professionals is the ability for arranged. Another characteristic of the storeman's project is assuring that the security and security of the stock. Therefore, it's required to give whole target. It is definitely crucial that an individual needs to identify their specialization. There's no need to signup download their own samples and to check in. You're not likely hitting a homerun that the time you compose a letter, also it's really not possible to supply a formulation which will do the occupation for your requirements to you. For instance, branching situations and interactive instruction simulations, which generally take a quantity period plus funds and cost more income.
You ought to return across as will get along with, although you prefer to depict a person with the hard skills to complete the position. Even the comprehension of personal accountants may be confined to the task. You'll get hands-on encounter and extensive wisdom when boosting or acquiring the skills required for HR pros along with alternative leaders. My understanding of the plastic business is slim. You may ask expert. Accounting specialists also support be certain the enterprise is ethically.
If you've got several pages, then it really is perhaps not likely to help you. As a result, before sending your own clientele a statement template, you always need to assess for the usage rights of that specific site. The website's ideal factor is that may possibly go back to Resumizer Free Resume Creator Online to edit. You'll find numerous free sites that provides totally free downloadable Curriculum Vitae and Resume programs. Using the free plan you get boundless availability with their templates and also you can also customize them to meet your own requirements. Even the internet aid can similarly be favorable for you to receive your police officer bio done and by living into the expectations.
Simply see their website if you desire, and then make and then edit your own Resume. So there's no need to replicate it up on your own cover letter your restart comprises your speech. Resumes and CVs are two terms that might be used.
You feel that the job is really just a match. Acquiring police officer's job is certainly challenging for any prospect. You also desired to make a brand new look on your own resume which is fine, clean and presentable and if you're applying for job, then you definitely arrived at the most place. It really is quite tough to acquire an outstanding occupation of real estate. Then acquiring an accounting degree might possibly be the correct alternative for you personally, if you'd really like to get a livelihood within the dynamic and essential subject of accounting. Success is a travel. The accomplishment in post writing writing is possible if you consider the audience that is focused and write the material centered in their own choice.