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Version: 17.07
Supported Since: 17.01
Extract Query Parameter Processor is a processing element which can be used to extract a query parameter from an integration flow and set it to a scope variable.
In order to use this processing element, you must first select the HTTP NIO Connector dependency from the connector list when you are creating an empty Ultra project. If you have already created a project, you can add the HTTP NIO Connector dependency via Component Registry. From Tools menu, select Ultra Studio → Component Registry and from the Connectors list, select the HTTP NIO Connector dependency.
The message will be sent to this outport if extracting query param is successful
On Exception
The message will be sent to this outport if the processing element failed in extracting query param operation
In the following diagram there is an integration flow which takes the message in from a http ingress connector and sends out using an http egress connector. During the integration I want to extract out an query parameter which was in the original HTTP request and set it to a scope variable for later use. In the next processing element I have used a Logger to log the extracted scope variable.

subset: commoncrawl


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Neil Patel co-founded Crazy Egg in 2005. 300,000 sites use Crazy Egg to know what's focusing on their site (with features like Heatmaps, Scrollmaps, Referral Maps, and User Recordings), fix what exactly isn't ( with a WYSIWYG Editor), and test new tips ( having a robust A/B Testing device).
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Here are the home sales figures for DC Ranch real estate in Scottsdale, Arizona for 2010. DC Ranch is a delightful community located in North Scottsdale, just north of the 101 freeway. It has housing options for everyone including condos and townhomes up to mutli-acre expansive estates.
This report will provide a snapshot of DC Ranch single-family home sales in Q1 and Q2 2010 as well as July 2010. Additionally, it contains active homes for sale in DC Ranch and pending home sales in DC Ranch.
As you can see, homes sales activity was slightly better in Q2 than Q1, but the average sales price of the homes was lower. Average price per square foot was up slightly.
Here are more recent statistics on the DC Ranch real estate market. Pending sales look to be on track with Q1 and Q2 monthly averages, but sales price and average asking price per square foot continue to decrease. July sales were strong, but again we see that the average sales price has moved to $750,492 whereas for Q1 and Q2, it was $863,667.
About Scottsdale's DC Ranch:
DC Ranch is a luxury community located in North Scottsdale. DC Ranch is broken into several different neighborhoods. These neighborhoods range from condo and townhome communities to multi-million dollar estates in guard-gated enclaves.
DC Ranch has its own K-8 school and two large community centers, Desert Camp and The Homestead. DC Ranch is also home to the DC Ranch Country Club, which is a private golf club with an 18-hole course designed by Tom Lehman and John Fought.
In additon to all the community offers, DC Ranch is also home to Market Street, a wonderful shopping, dining, personal care and entertainment district.
Search DC Ranch homes for sale.
Disclaimer: Information herein deemed reliable but not guaranteed. Data pulled from the Arizona Regional MLS (ARMLS) as of 4/1/2010 (Q1), 7/1/2010 (Q2) and 8/23/2010 (July and current information) and can change at any time. This blog represents the opinion of the author. No warranties implied or expressed.
Copyright © 2010 Heather Tawes Nelson


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Tip & How-To about Bob's Red Mill Natural Foods Cooking
A teaspoon of Baking soda poured down your plug and wash it down with 250 ml of white vinegar. the plug will fizz and bubble. Leave for about 10/20 minutes and wash down running water. This will leave your plugs free from most debris and the likelihood of a clogg or blockage is greatly reduced.
Smells better too.
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Goldman Sachs' (GS) upstart digital consumer bank is looking to attract new customers by partnering with a digitally-savvy retail mortgage lender.
Marcus by Goldman Sachs is teaming up with Guaranteed Rate, one of the largest retail mortgage lenders in the U.S., to offer customers seeking to consolidate their debt or fund a home improvement project. Applicants who are approved can access its fixed-rate, no-fee personal loans of up to $40,000.
To be sure, Goldman isn't getting into mortgage lending, or facilitating mortgages by personal loans. Instead, the idea is to open itself up to new customers who might not have used Marcus through this distributive relationship.
"We have talked a lot about how we are thinking about Marcus' growth strategy. We love to be at places where customers shop," Abhinav Anand, Marcus' head of consumer loans, told Yahoo Finance in a telephone interview.
Victor Ciardelli, the founder and CEO of Guaranteed Rate, explained that one of the opportunities is for customers to use a personal loan to consolidate debt and improve their FICO score — which can lead to a better rate for new mortgages or refinancing.
Initial feedback from consumers "has exceeded all our expectations," Ciardelli said.
Another challenge the Marcus personal loan solves for is when home sellers need to make improvements to the property to get the opportunity for the maximum value of a home.
Real estate professionals "now have a tool to help them maximize home values and quicker salability of homes, and it also gives an opportunity for sellers to also get out of the home they're in and get into another home that they want," Ciardelli added.
According to Ciardelli, it was Guaranteed Rate which first approached Goldman Sachs about the strategic partnership.
Anand added that it made sense because Guaranteed Rate is a "like-minded brand" with a focus on "customer-centricity." He also noted that Marcus' digital offering integrates well with the technology stack of Guaranteed Rate, which was the first lender to offer a digital mortgage.
Ciardelli added that the experience his customers see so far with Marcus is that it's easy, efficient, and comes from "a trusted brand."
Even though Marcus won't be the source of mortgage lending, Guaranteed Rate's loan officers will feature the Marcus tab on the front page of their websites, and it will also be on the homepage of the corporate website.
The lender's real estate partners can also refer home buyers and sellers to those sites to apply for personal loans.
"As this partnership would grow, we have plans, and we are very sure that the customers for Guaranteed Rate would start looking at Marcus products across their financial lifecycle," Anand said.
Goldman's upstart financial services platform that caters to younger, technology-savvy consumers made its debut three years ago. It's named after the bank's founder, Marcus Goldman, and is described by the bank as "a startup within a 150-year old firm." This summer, Marcus received a J.D. Power award for U.S. personal loan satisfaction.
Traditionally, Goldman's clients had included corporations, financial institutions, governments, and high-net-worth individuals, but not Main Street consumers.
To date, Marcus has over 4 million customers, and it's given out north of $5 billion in consumer loans and accumulated close to $55 billion in deposits. This summer, Marcus partnered with Apple for Apple Card, a digital and physical credit card.
Julia La Roche is a Correspondent at Yahoo Finance. Follow her on Twitter.
Read the latest financial and business news from Yahoo Finance
How Goldman plans to disrupt banking like Amazon did retail, Apple in music
How Goldman plans to boost its reputation with its upstart digital bank Marcus
Follow Yahoo Finance on Twitter, Facebook, Instagram, Flipboard, SmartNews, LinkedIn, YouTube, and reddit.


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Members of Boys Republic and Brave Girls are going on KBS 2TV's�'The Unit'.
'The Unit' is a new idol rebooting program that aims to give a second chance to those idols who failed to gain the�spotlight.�
On August 17, producers of 'The Unit' confirmed the members of Boys Republic and Brave Girls are participating in the show.�
A rep from Brave Girls' label also confirmed, "Yuna, Eunji, and Yoojung�are participating in 'The Unit'.''
Meanwhile,�rumors stated�that a member of�AOA�is also joining the new program but nothing has been confirmed as of yet.�
'The Unit' is scheduled to air in October.�


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Sony announces £90 PlayStation One Classic that is 50% smaller than the original '90s video game console and comes pre-loaded with 20 games
- The £90 ($100) PlayStation One Classic is small enough to hold in a single hand
- It comes with Final Fantasy VII, Tekken 3, R4: Ridge Racer Type 4, and more
- The console is now available for pre-order ahead of its launch on December 3
Sony has unveiled a shrunken version of its classic Playstation One video games console that comes pre-loaded with 20 classic titles.
The £90 ($100) PlayStation One Classic is almost half the size of Sony's original 1994 console, making it small enough to hold in one hand.
It is available for pre-order now ahead of its release on December 3 – exactly 24 years after the original release date for the console.
Sony is following in the footsteps of fellow Japanese games-maker Nintendo, which has released miniature versions of two of its classic consoles in recent years.
The nostalgic re-issues of the classic consoles have been hugely popular amongst Nintendo fans, with the most recent SNES Classic Mini has sold 5.28 million units worldwide since its launch in September 2017.
Scroll down for video
The £90 ($100) PlayStation One Classic is almost half the size of Sony's original 1994 console, making it small enough to hold in one hand
Like Nintendo's NES Classic and SNES Classic, the PlayStation Classic comes preloaded with a slew of nostalgic hits from the system's original back catalogue.
Sony has announced five so far — Final Fantasy VII, Tekken 3, R4: Ridge Racer Type 4, Jumping Flash! and Wild Arms.
'All of the pre-loaded games will be playable in their original format,' the company said.
Sony says it will announce the remaining 15 games before launch later this year.
The PlayStation One Classic come with two controllers and an HDMI slot, which is used to connect the updated 1994 console to modern HD TVs.
The controllers are full-size replicas of the PS1's original gamepads, not the later DualShock ones, and so don't include analog sticks or vibration.
The console comes packed with a list of hits from the system's original library. Sony has announced five so far: Final Fantasy VII, Tekken 3, R4: Ridge Racer Type 4, Jumping Flash! and Wild Arms
Sony has announced five games so far.
- Final Fantasy VII
- Tekken 3
- R4: Ridge Racer Type 4
- Jumping Flash!
- Wild Arms
Saved files are stored on a virtual memory card, meaning your original PS1 saves will not be salvageable.
The console is 45 per cent smaller than the original system, and features replicas of the buttons seen on the original system.
However, since the console uses an internal software database of games — players will not need to manually swap-out disks.
Instead, the open button on the PS One Classic switches virtual discs, while the 'reset' is used to quit games in progress.
The console is now available for pre-order in Japan, Europe, the US, and UK ahead of its release December 3.
The shrunken down console is available for pre-order now ahead of its release on December 3 - exactly 24 years on from the console's original release
The PlayStation One Classic come with two controllers and an HDMI slot, meaning you can connect it to your modern TV
It is shipping for $99.99 in the US, while the UK version costs just under £89.99.
The announcement continues a trend of big-name gaming firms releasing miniature versions of classic products.
Nintendo has had huge success in the last two years by releasing scaled down versions of the NES and SNES consoles – both of which quickly sold out.
Sega has since joined the market and is planning to launch a mini version of its 90s console the Mega Drive next year.
The original Sony PlayStation One (right) was the first console to sell 100 million units worldwide. The new Classic version (left) is due for release in December
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"Do mundo corporativo para o mundo."
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Kenyans are such crybabies yet their value systems stink
For More of This and Other Stories, Grab Your Copy of the Standard Newspaper.Why weren't travel advisories being issued against France? They posed, and did not wait for an answer because they already knew it: the West is hell bent on impoverishing Africa, and specifically Kenya which is thriving in the face of adversity and does not need them because it is looking East — while it is blindfolded. The funny bit about these people is they could as well have sold their parents to buy an air ticket to France at that time when they were considering the place so unsafe that Kenya should have issued travel advisories against it. Of course terrorism is a global problem — and that is a wonderful excuse for a nation which thinks its problems are all caused by outsiders — and it is not fair for Western nations to abandon Kenya at its time of need. However, what Kenyans were not saying is that, despite their patriotism, they never visited any of those areas attacked by terrorists to disabuse of the notion that Kenya is unsafe. As a matter of fact, Kenyans are always the first to want out of these "unsafe" areas, and sadly, the first people to complain about insecurity in such areas are government employees who demand transfers to safer places because their security is not guaranteed. Another thing that many failed to understand, and deliberately so because in Kenya, it is chic to blame foreigners, was that French authorities started hunting down the attackers, instead of attacking one another and calling each other names. The country was united you can say, or that is the message that came across, but what happens in Kenya after a terrorist attack? The authorities start blaming those who are not in power, political analysts start analysing the ethnic groupings of the casualties and fatalities, and then they start engaging in their favourite workout regime — jumping to conclusions — that a certain tribe which they belong to is being targeted. When terrorist attacks happen in other countries where authorities do not rely on the interpretation of clueless political analysts, the victims are first viewed as citizens, and not members of a certain ethnic community. Foreign powers Then the people who have been given the mandate by the tax payers assure their employers, the citizens, that all is well — and that they do not do through rhetoric or hash tags or warnings or by deploying attack dogs, lapdogs and other hounds to foam at all their orifices in public rallies, but through meaningful action. It is not easy to understand how a nation which prides itself in being a regional powerhouse can be so full of crybabies who are so fast on holding pity parties and seeing themselves as victims of some foreign powers. Interference by foreign powers cannot be ruled out in certain circumstances, but it is also imperative for the self-styled victims to have a re-look in to their value systems and ask themselves why the foreigners interfere in their internal affairs. Is Kenya not that country where laws are just but proposals that do not have to be followed, and are often times applied selectively? Is Kenya not the same country where leaders denounce certain countries at night, and in the morning send their children to those same places for further studies or they themselves visit for medical attention when they have as much as a running nose? Is Kenya not the place where thieves are feted, and those who question them are wished away as political enemies who are seeking validation by asking nonsensical questions? Is Kenya not the country where non-state bodies are hounded by the powers that be because they are funded by foreign bodies and can therefore, only be anti-government yet the State itself cannot offer half the services those bodies offer? It is an open secret that Kenya is a country without any value systems, a country where leaders are more at home when calling each other names, when spewing hatred, when inciting communities against one another, than when they are trying to bring reconciliation and ensure that citizens live peacefully. Kenya happens to be that place where public officials deliberately run down public sectors so that the private ones which they own, or which are owned by their cronies can thrive — it is that country where there is no parcel of land high-ranking government officials did not want to grab. Yes, Kenya is that country where leaders worship poverty — they pray that their voters forever remain poor so that they can appreciate whatever crumbs thrown their way, and treat their benefactors, the thieving politicians, as gods and goddesses who are always helping them. Common enemy I am always made to understand that terrorists who attack Kenya always want to divide the country along different lines, a situation they can exploit to their advantage, if you can call killing innocent victims an advantage. Thus it is important for Kenyans to stay united, and not blame the entity that collects taxes, but instead come together in fighting a common enemy, the terrorists or the foreign bandits. Well, from the look of things, the attackers do not have to try hard because Kenya is forever divided along more lines than the terrorists can ever imagine — and it should not be forgotten that Kenyan politicians love mourning or shedding crocodile tears to uphold the country's motto of United in Grief.
Do not miss out on the latest news. Join the Standard Digital Telegram channel HERE.


text:
Research Topics
Genomes and Genes
Gene Symbol: CACNA1G
Description: calcium voltage-gated channel subunit alpha1 G
Alias: Ca(V)T.1, Cav3.1, NBR13, SCA42, voltage-dependent T-type calcium channel subunit alpha-1G, calcium channel, voltage-dependent, T type, alpha 1G subunit, cav3.1c, voltage-dependent T-type calcium channel alpha 1G subunit, voltage-dependent calcium channel alpha 1G subunit, voltage-gated calcium channel subunit alpha Cav3.1
Species: human
Products: CACNA1G
Top Publications
Scientific Experts
More Information
Publications140 found, 100 shown here
- Zhang Q, He M, Wang J, Liu S, Cheng H, Cheng Y. Predicting of disease genes for gestational diabetes mellitus based on network and functional consistency. Eur J Obstet Gynecol Reprod Biol. 2015;186:91-6 pubmed publisher..network and functional consistency, 6 candidate genes of GDM were considered to be candidate disease genes of GDM, including CYP1A1, LEPR, ESR1, GYS2, AGRP, and CACNA1G. However, further studies are required to validate these results.
- Chernov Rogan T, Li T, Lu G, Verschoof H, Khakh K, Jones S, et al. Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors. Proc Natl Acad Sci U S A. 2018;115:E792-E801 pubmed publisher..7-selective chemical scaffolds. Hence, we address a major hurdle in Nav1.7 drug discovery, and this mechanistic approach to assay design is applicable to Cav3.1, Kv1.3, and many other ion channels to facilitate drug discovery. ..
- Mesirca P, Torrente A, Mangoni M. T-type channels in the sino-atrial and atrioventricular pacemaker mechanism. Pflugers Arch. 2014;466:791-9 pubmed publisher..Accordingly, loss-of-function of Cav3.1 channels contributes to severe form of congenital bradycardia and atrioventricular block in paediatric patients. ..
- Cha Y, Kim S, Yeo H, Baek J, Choi M, Jung K, et al. Association of CHFR Promoter Methylation with Treatment Outcomes of Irinotecan-Based Chemotherapy in Metastatic Colorectal Cancer. Neoplasia. 2019;21:146-155 pubmed publisher..SULF2) associated with chemotherapy response and five CpG island methylator phenotype (CIMP)-specific markers (CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1)...
- Visa A, Sallán M, Maiques O, Alza L, Talavera E, López Ortega R, et al. T-Type Cav3.1 Channels Mediate Progression and Chemotherapeutic Resistance in Glioblastoma. Cancer Res. 2019;79:1857-1868 pubmed publisher..Here we analyzed the expression of TTCC transcripts in human GBM cells and show a prevalence of Cacna1g/Cav3.1 mRNAs...
- Hu S, Li L, Huang W, Liu J, Lan G, Yu S, et al. CAV3.1 knockdown suppresses cell proliferation, migration and invasion of prostate cancer cells by inhibiting AKT. Cancer Manag Res. 2018;10:4603-4614 pubmed publisher..Upregulated CAV3.1 is positively associated with the development of PCa. CAV3.1 knockdown can inhibit PCa cell proliferation, migration, and invasion by suppressing AKT activity. ..
- Berg M, Nordgaard O, Kørner H, Oltedal S, Smaaland R, Søreide J, et al. Molecular subtypes in stage II-III colon cancer defined by genomic instability: early recurrence-risk associated with a high copy-number variation and loss of RUNX3 and CDKN2A. PLoS ONE. 2015;10:e0122391 pubmed publisher..2 (95% CI 1.1-9.3; P = 0.026). Losses of CACNA1G (OR of 2.9, 95% CI 1.4-6.0; P = 0.001), IGF2 (OR of 4.3, 95% CI 1.1-15.8; P = 0.007), CDKN2A (p16) (OR of 2...
- Cheng X, Ma L, Feng X, Zhu M, Zhang D, Xu L, et al. Antigen retrieval pre-treatment causes a different expression pattern of Cav3.2 in rat and mouse spinal dorsal horn. Eur J Histochem. 2019;63: pubmed publisher..2 but not GFAP. Together, our findings indicate that AR pre-treatment or not impacts the expression pattern of Cav3.2, which may make a significant contribution to the future study of Cav3.2 in SDH. ..
- Handforth A, Homanics G, Covey D, Krishnan K, Lee J, Sakimura K, et al. T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor. Neuropharmacology. 2010;59:380-7 pubmed publisher..It is uncertain whether medications developed to block only the Cav3.1 subtype would exhibit efficacy. ..
- Tevoufouet E, Nembo E, Dibué Adjei M, Hescheler J, Nguemo F, Schneider T. Cardiac functions of voltage-gated Ca(2+) channels: role of the pharmacoresistant type (E-/R-Type) in cardiac modulation and putative implication in sudden unexpected death in epilepsy (SUDEP). Rev Physiol Biochem Pharmacol. 2014;167:115-39 pubmed publisher
- Sharop B, Boldyriev O, Batiuk M, Shtefan N, Shuba Y. Compensatory reduction of Cav3.1 expression in thalamocortical neurons of juvenile rats of WAG/Rij model of absence epilepsy. Epilepsy Res. 2016;119:10-2 pubmed publisher..The weakened expression of Cav3.1 in juveniles of WAG/Rij rats could represent a compensatory mechanism determining the pattern of the age dependency in the disease manifestation by this model of absence epilepsy. ..
- Sun X, Wang Q, Guo B, Liu X, Wang B. Identification of skin-related lncRNAs as potential biomarkers that involved in Wnt pathways in keloids. Oncotarget. 2017;8:34236-34244 pubmed publisher..As a result, four lncRNAs including CACNA1G-AS1, HOXA11-AS, LINC00312 and RP11-91I11...
- Lee S, Lee C, Woo C, Kang S, Shin K. Chronic social defeat stress-induced enhancement of T-type calcium channels increases burst-firing neurons in the ventral subiculum. Biochem Biophys Res Commun. 2018;: pubmed publisher..Therefore, we conclude that CSDS-induced enhancement of Cav3.1 expression increased bursting neuronal population in the vSub, which may contribute to stress-related behaviors. ..
- Howarth F, Qureshi M, Jayaprakash P, Parekh K, Oz M, Dobrzynski H, et al. The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart. J Diabetes Res. 2018;2018:8454078 pubmed publisher..3), Cacna1g (Cav3.1), Cacna1h (Cav3...
- Liu Y, Wang P, Ma F, Zheng M, Liu G, Kume S, et al. Asparagine-linked glycosylation modifies voltage-dependent gating properties of CaV3.1-T-type Ca2+ channel. J Physiol Sci. 2019;69:335-343 pubmed publisher..1-T-type Ca2+ channel but to the regulation of the gating properties of the channel when the channel proteins were processed during the folding and trafficking steps in the cell. ..
- Sekiguchi F, Kawara Y, Tsubota M, Kawakami E, Ozaki T, Kawaishi Y, et al. Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain. Pain. 2016;157:1655-65 pubmed publisher..1/Cav3.2 T channels and may serve as an orally available analgesic for treatment of neuropathic and inflammatory pain including distinct visceral pain with minimum central side effects. ..
- Cohen S, Yu M, Baker K, Redman M, Wu C, Heinzerling T, et al. The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases. Clin Epigenetics. 2017;9:46 pubmed publisher..the CIMP status of 70 pairs of primary CRC and matched metastases using a CRC-specific panel of five markers (CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1) where CIMP positive was defined as 3/5 positive ..
- Liu Y, Iwano T, Ma F, Wang P, Wang Y, Zheng M, et al. Short- and long-term roles of phosphatidylinositol 4,5-bisphosphate PIP2 on Cav3.1- and Cav3.2-T-type calcium channel current. Pathophysiology. 2019;26:31-38 pubmed publisher..1-ICa.T. PIP2 modulates CaV3.1- and CaV3.2-ICa.T not by their current density but by their channel gating properties possibly through its membrane-delimited actions. ..
- Hühns M, Krohn S, Murua Escobar H, Prall F. Genomic heterogeneity in primary colorectal carcinomas and their metastases: born bad or brought up a villain?. Hum Pathol. 2018;74:54-63 pubmed publisher..D9S942, D9S1748, D5S346, D5S1385) and DNA methylation studies with a marker panel (MLH1, CDNK2A, NEUROG1, CRABP1, CACNA1G, IGF2, RUNX3, SOCS1) showed remarkably "insular" genomic aberrations in all cases for at least some of the ..
- Shin A, Woo J, Kim J, Kim D. Nodding behavior couples to vigilance fluctuation in a high-calorie diet model of drowsiness. Mol Brain. 2018;11:33 pubmed publisher..Our findings indicate that delta oscillations play a dominant role in controlling vigilance dynamics during sleep/wake competition and that our novel mouse model may be useful for studying drowsiness and related neurological disorders. ..
- Garcia Caballero A, Zhang F, Hodgkinson V, Huang J, Chen L, Souza I, et al. T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B. Mol Brain. 2018;11:24 pubmed publisher..2 in hippocampal neurons. These findings reveal spectrin (α/β) / ankyrin B cytoskeletal and signaling proteins as key regulators of T-type calcium channels expressed in the nervous system. ..
- Elíes J, Johnson E, Boyle J, Scragg J, Peers C. H2S does not regulate proliferation via T-type Ca2+ channels. Biochem Biophys Res Commun. 2015;461:659-64 pubmed publisher..1. Our data indicate that inhibition of T-type Ca(2+) channel-mediated proliferation by H2S is independent of the channels' sensitivity to H2S. ..
- Harraz O, Visser F, Brett S, Goldman D, Zechariah A, Hashad A, et al. CaV1.2/CaV3.x channels mediate divergent vasomotor responses in human cerebral arteries. J Gen Physiol. 2015;145:405-18 pubmed publisher..In conclusion, this study documents the expression of three distinct Ca(2+) channel subtypes in human cerebral arteries and further shows how they act together to orchestrate arterial tone. ..
- Kim J, Cho N, Bae J, Kim K, Rhee Y, Lee H, et al. Nuclear maspin expression correlates with the CpG island methylator phenotype and tumor aggressiveness in colorectal cancer. Int J Clin Exp Pathol. 2015;8:1920-8 pubmed..by methylation-specific quantitative PCR method (MethyLight) using eight CIMP markers (MLH1, NEUROG1, CRABP1, CACNA1G, CDKN2A (p16), IGF2, SOCS1, and RUNX3) in 216 MSI-H CRCs...
- Ranzato E, Magnelli V, Martinotti S, Waheed Z, Cain S, Snutch T, et al. Epigallocatechin-3-gallate elicits Ca2+ spike in MCF-7 breast cancer cells: essential role of Cav3.2 channels. Cell Calcium. 2014;56:285-95 pubmed publisher..2 currents. Cav3.2 channels are in part responsible for EGCG inhibition of MCF-7 viability, suggesting that deregulation of [Ca(2+)]i by EGCG may be relevant in breast cancer treatment. ..
- Jung S, Jeong Y, Jeon D. Epileptic activity during early postnatal life in the AY-9944 model of atypical absence epilepsy. Cell Calcium. 2015;57:376-84 pubmed publisher..Our findings may aid our understanding of the pathophysiological mechanisms of clinical AAE in individuals, such as those with Lennox-Gastaut syndrome. ..
- Haverinen J, Hassinen M, Dash S, Vornanen M. Expression of calcium channel transcripts in the zebrafish heart: dominance of T-type channels. J Exp Biol. 2018;221: pubmed publisher..The large ventricular ICaT is likely to play a significant role in E-C coupling. ..
- Elíes J, Scragg J, Huang S, Dallas M, Huang D, MacDougall D, et al. Hydrogen sulfide inhibits Cav3.2 T-type Ca2+ channels. FASEB J. 2014;28:5376-87 pubmed publisher..Our data demonstrate a novel target for H2S regulation, the T-type Ca(2+) channel Cav3.2, and suggest that such modulation cannot account for the pronociceptive effects of this gasotransmitter. ..
- Park Y, Choi J, Lee C, Kim S, Kim Y, Chang K, et al. Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice. Mol Brain. 2015;8:3 pubmed publisher..1Â T-type Ca(2+) channels (Cacna1g), in which the tremor caused by the absence of Gabra1 is potentiated by the absence of Cacna1g, showed a coherent ..
- Monteil A, Chausson P, Boutourlinsky K, Mezghrani A, Huc Brandt S, Blesneac I, et al. Inhibition of Cav3.2 T-type Calcium Channels by Its Intracellular I-II Loop. J Biol Chem. 2015;290:16168-76 pubmed publisher..2 and Cav3.3 channels, only the fast inactivating T-type current (Cav3.2 component) was significantly inhibited. Altogether, these data describe a new strategy to differentially inhibit Cav3 isoforms of the T-type calcium channels. ..
- Choi S, Yu E, Hwang E, Llinás R. Pathophysiological implication of CaV3.1 T-type Ca2+ channels in trigeminal neuropathic pain. Proc Natl Acad Sci U S A. 2016;113:2270-5 pubmed publisher..1 knockout mice. Our results suggest that the presence of CaV3.1 channels is a key element in the pathophysiology of trigeminal neuropathic pain. ..
- Pudukulatham Z, Zhang F, Gadotti V, M Dahoma S, Swami P, Tamboli Y, et al. Synthesis and characterization of a disubstituted piperazine derivative with T-type channel blocking action and analgesic properties. Mol Pain. 2016;12: pubmed publisher..2 channels. Altogether, our data identify a novel T-type calcium channel blocker with tight structure activity relationship (SAR) and relevant in vivo efficacy in inflammatory pain conditions. ..
- Gangadharan G, Shin J, Kim S, Kim A, Paydar A, Kim D, et al. Medial septal GABAergic projection neurons promote object exploration behavior and type 2 theta rhythm. Proc Natl Acad Sci U S A. 2016;113:6550-5 pubmed publisher..These findings define object exploration distinguished from open-field exploration and reveal a critical role of T-type Ca(2+) channels in the medial septal GABAergic projection neurons in this behavior. ..
- Kim M, Jung H, Kim S, Park J, Seo Y. Electromagnetic fields and nanomagnetic particles increase the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Int J Mol Med. 2015;35:153-60 pubmed publisher..Furthermore, the mRNA expression of calcium channels (CACNA1C, CACNA1E, CACNA1G and CACNA1I) was activated during osteogenic differentiation...
- Sakkaki S, Gangarossa G, Lerat B, Françon D, Forichon L, Chemin J, et al. Blockade of T-type calcium channels prevents tonic-clonic seizures in a maximal electroshock seizure model. Neuropharmacology. 2016;101:320-9 pubmed publisher..Overall, our data indicate that TTA-A2 is a potent anticonvulsant and that the Cav3.1 isoform plays a prominent role in mediating TTA-A2 tonic seizure protection. ..
- Cohen S, Wu C, Yu M, Gourgioti G, Wirtz R, Raptou G, et al. Evaluation of CpG Island Methylator Phenotype as a Biomarker in Colorectal Cancer Treated With Adjuvant Oxaliplatin. Clin Colorectal Cancer. 2016;15:164-9 pubmed publisher..CIMP status was determined using the DNA methylation status of CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1. Cox models were used to assess the association of CIMP with survival...
- Gallois C, Taieb J, Le Corre D, Le Malicot K, Tabernero J, Mulot C, et al. Prognostic value of methylator phenotype in stage III colon cancer treated with oxaliplatin-based adjuvant chemotherapy. Clin Cancer Res. 2018;: pubmed publisher..PCR where CIMP+ status was defined by methylation of at least three of the five following genes: IGF2, CACNA1G, NEUROG1, SOCS1, and RUNX3...
- Calderón Rivera A, Sandoval A, González RamÃrez R, González Billault C, Felix R. Regulation of neuronal cav3.1 channels by cyclin-dependent kinase 5 (Cdk5). PLoS ONE. 2015;10:e0119134 pubmed publisher..1subunit. These results highlight a novel role for Cdk5 in the regulation of T-type Ca2+ channels. ..
- Yu P, Kang A, Jing L, Wang Y. Long non-coding RNA CACNA1G-AS1 promotes cell migration, invasion and epithelial-mesenchymal transition by HNRNPA2B1 in non-small cell lung cancer. Eur Rev Med Pharmacol Sci. 2018;22:993-1002 pubmed publisher..The purpose of this study was to investigate the role of CACNA1G-AS1 in non-small cell lung cancer (NSCLC)...
- Hansen P. Functional importance of T-type voltage-gated calcium channels in the cardiovascular and renal system: news from the world of knockout mice. Am J Physiol Regul Integr Comp Physiol. 2015;308:R227-37 pubmed publisher..In conclusion, Cav3.1 and Cav3.2 are new therapeutic targets in several cardiovascular pathologies, but the use of T-type blockers should be specifically directed to the disease and to the channel subtype. ..
- Wang H, Zhang X, Xue L, Xing J, Jouvin M, Putney J, et al. Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles. Immunity. 2016;44:782-94 pubmed publisher..1-deficient T cells. These data provide evidence for T-type channels in immune cells and their potential role in shaping the autoimmune response. ..
- Winkel B, Yuan L, Olesen M, Sadjadieh G, Wang Y, Risgaard B, et al. The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome. Heart Rhythm. 2015;12:1241-9 pubmed publisher..In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes. ..
- Busch E, Galanko J, Sandler R, Goel A, Keku T. Lifestyle Factors, Colorectal Tumor Methylation, and Survival Among African Americans and European Americans. Sci Rep. 2018;8:9470 pubmed publisher..Tumor methylation was assessed in CACNA1G, MLH1, NEUROG1, RUNX3, and SOCS1...
- Tomášová L, Pavlovicová M, Malekova L, Misak A, Kristek F, Grman M, et al. Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels. Nitric Oxide. 2015;46:131-44 pubmed publisher
- Tompkins J, Merriam L, Girard B, May V, Parsons R. Nickel suppresses the PACAP-induced increase in guinea pig cardiac neuron excitability. Am J Physiol Cell Physiol. 2015;308:C857-66 pubmed publisher..Together, our results suggest that a PACAP-enhanced, Ni(2+)-sensitive current contributes to PACAP-induced modulation of neuronal excitability. ..
- Park S, Min S, Kang H, Lee J. Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3. Biochim Biophys Acta. 2015;1848:2092-100 pubmed publisher..2. In overall, we provide evidence that Cav1.2 and Cav1.3 isoforms are capable of potentially functioning as zinc permeation routes, through which zinc entry can be differentially augmented by mild acidifications. ..
- Boudreau Béland J, Duverger J, Petitjean E, Maguy A, Ledoux J, Comtois P. Spatiotemporal stability of neonatal rat cardiomyocyte monolayers spontaneous activity is dependent on the culture substrate. PLoS ONE. 2015;10:e0127977 pubmed publisher..These results reveal the importance of carefully selecting the culture substrate for studies involving mechanical stimulation, especially for tissue engineering or pharmacological high-throughput screening of cardiac tissue analog. ..
- Pan Y, Li B, Wang J, Li X. Rosuvastatin Alleviates Type 2 Diabetic Atrial Structural and Calcium Channel Remodeling. J Cardiovasc Pharmacol. 2016;67:57-67 pubmed publisher..In conclusion, long-term RSV therapy can alleviate structural and calcium channel remodeling in the type 2 diabetic rat atrium. ..
- Frandsen R, Salomonsson M, Hansen P, Jensen L, Braunstein T, Holstein Rathlou N, et al. No apparent role for T-type Ca²⺠channels in renal autoregulation. Pflugers Arch. 2016;468:541-50 pubmed publisher..1 or treatment with low concentrations of mibefradil does not affect renal autoregulation. Thus, T-type calcium channels are not involved in renal autoregulation in response to acute increases in RPP. ..
- Wen X, Xu S, Zhang Q, Li X, Liang H, Yang C, et al. Inhibitory gene expression of the Cav3.1 T-type calcium channel to improve neuronal injury induced by lidocaine hydrochloride. Eur J Pharmacol. 2016;775:43-9 pubmed publisher..In this study, we observed the effects of lidocaine hydrochloride on the pshRNA-CACNA1G-SH-SY5Y cells that silenced Cav3...
- Yabuki Y, Matsuo K, Izumi H, Haga H, Yoshida T, Wakamori M, et al. Pharmacological properties of SAK3, a novel T-type voltage-gated Ca2+ channel enhancer. Neuropharmacology. 2017;117:1-13 pubmed publisher..1 knockout (KO) mice. These findings suggest overall that T-VGCCs play a key role in cognition by enhancing hippocampal ACh release and that the cognitive enhancer SAK3 could be a candidate therapeutic in Alzheimer's disease. ..
- Liang X, Ma L, Long X, Wang X. LncRNA expression profiles and validation in keloid and normal skin tissue. Int J Oncol. 2015;47:1829-38 pubmed publisher..Furthermore, bioinformation analysis suggested that lncRNA CACNA1G-AS1 may be crucial to keloid formation...
- Slawinska A, Plowiec A, Siwek M, Jaroszewski M, Bednarczyk M. Long-Term Transcriptomic Effects of Prebiotics and Synbiotics Delivered In Ovo in Broiler Chickens. PLoS ONE. 2016;11:e0168899 pubmed publisher..transport (BEST4, SLC9A3, and SLC13A2), metabolism (OGT, ALPP, CA4, and CA7), signaling (FGG, G3BP2, UBB, G3BP2, CACNA1G, and ATP6V0A4), and immune responses (MSMB, LGALS3, CABIN1, CXCR5, PAX5, and TNFRSF14)...
- Devergnas A, Chen E, Ma Y, Hamada I, Pittard D, Kammermeier S, et al. Anatomical localization of Cav3.1 calcium channels and electrophysiological effects of T-type calcium channel blockade in the motor thalamus of MPTP-treated monkeys. J Neurophysiol. 2016;115:470-85 pubmed publisher..Whereas the described changes are promising, a more complete assessment of the cellular and behavioral effects of ML218 (or similar drugs) is needed for a full appraisal of their anti-Parkinsonian potential. ..
- Tikkanen E, Haverinen J, Egginton S, Hassinen M, Vornanen M. Effects of prolonged anoxia on electrical activity of the heart in crucian carp (Carassius carassius). J Exp Biol. 2017;220:445-454 pubmed publisher..2b K+ channel gene (kcnj12b), whereas expression of Ca2+ (cacna1a, cacna1c and cacna1g) and Na+ channel genes (scn4a and scn5a) was not affected...
- Tracy M, Tesic V, Stamenić T, Joksimovic S, Busquet N, Jevtovic Todorovic V, et al. CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons. Neuropharmacology. 2018;135:343-354 pubmed publisher..1 T-type channels in drug response. We conclude that pharmacological targeting of CaV3.1 isoform of T-channels may be a novel approach for the treatment of disorders of mesolimbic reward system. ..
- Weaver E, Zamora F, Hearne J, Martin Caraballo M. Posttranscriptional regulation of T-type Ca(2+) channel expression by interleukin-6 in prostate cancer cells. Cytokine. 2015;76:309-320 pubmed publisher..These results indicate that the functional expression of T-type Ca(2+) channels is regulated by the interplay of multiple factors in LNCaP cells. ..
- KarmažÃnová M, JaÅ¡ková K, Griac P, Perez Reyes E, Lacinová Ä. Contrasting the roles of the I-II loop gating brake in CaV3.1 and CaV3.3 calcium channels. Pflugers Arch. 2015;467:2519-27 pubmed publisher..We suggest that activation of the voltage sensor in domain I is limiting both the voltage dependence and the kinetics of CaV3 channel activation. ..
- Yang W, Li Q, Wang S, Gao F, Qian W, Li F, et al. Cannabinoid receptor agonists modulate calcium channels in rat retinal Müller cells. Neuroscience. 2016;313:213-24 pubmed publisher..The existence of receptor-dependent and -independent mechanisms suggests that cannabinoids may modulate Müller cell functions through multiple pathways. ..
- Cain S, Ahn S, Garcia E, Zhang Y, Waheed Z, Tyson J, et al. Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing. Mol Brain. 2016;9:94 pubmed
- Jeong K, Lee S, Seo H, Oh Y, Jang D, Choe J, et al. Ca-α1T, a fly T-type Ca2+ channel, negatively modulates sleep. Sci Rep. 2015;5:17893 pubmed publisher..Thus, our study suggests invertebrate T-type Ca(2+) channels promote wakefulness rather than stabilizing sleep. ..
- Mitani K, Sekiguchi F, Maeda T, Tanaka Y, Yoshida S, Kawabata A. The prostaglandin E2/EP4 receptor/cyclic AMP/T-type Ca(2+) channel pathway mediates neuritogenesis in sensory neuron-like ND7/23 cells. J Pharmacol Sci. 2016;130:177-80 pubmed publisher..The neuritogenesis induced by db-cAMP or PGE2 was abolished by T-channel blockers. T-channels were functionally upregulated by db-cAMP. The PGE2/EP4/cAMP/T-channel pathway thus appears to mediate neuritogenesis in sensory neurons. ..
- Calhoun J, Hawkins N, Zachwieja N, Kearney J. Cacna1g is a genetic modifier of epilepsy caused by mutation of voltage-gated sodium channel Scn2a. Epilepsia. 2016;57:e103-7 pubmed publisher..Genetic mapping and RNA-Seq analysis identified Cacna1g as a candidate modifier gene at the Moe1 locus, which influences Scn2a(Q54) phenotype severity...
- Shiovitz S, Bertagnolli M, Renfro L, Nam E, Foster N, Dzieciatkowski S, et al. CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer. Gastroenterology. 2014;147:637-45 pubmed publisher..from available tumor samples (n = 615) was used to determine CIMP status based on methylation patterns at the CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1 loci...
- Tatsuki F, Sunagawa G, Shi S, Susaki E, Yukinaga H, Perrin D, et al. Involvement of Ca(2+)-Dependent Hyperpolarization in Sleep Duration in Mammals. Neuron. 2016;90:70-85 pubmed publisher..Here we found that impaired Ca(2+)-dependent K(+) channels (Kcnn2 and Kcnn3), voltage-gated Ca(2+) channels (Cacna1g and Cacna1h), or Ca(2+)/calmodulin-dependent kinases (Camk2a and Camk2b) decrease sleep duration, while impaired ..
- Lin X, Lim I, Wu Y, Teh A, Chen L, Aris I, et al. Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome. BMC Med. 2017;15:50 pubmed publisher..Neonatal methylation markers from seven gene loci (ANK3, CDKN2B, CACNA1G, IGDCC4, P4HA3, ZNF423 and MIRLET7BHG) were significantly associated with birth weight, with a subset of these in ..
- Wen X, Zhong J, Zhang T, Lai X, Liu H, Wang H, et al. [Role of calmodulin-dependent protein kinase II in bupivacaine hydrochloride-induced injury of SH-SY5Y cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2015;35:1133-6 pubmed..All these changes were partly reversed by treatment of the cells with 1 mmol/L KN93. CaMKII may play a role in bupivacaine hydrochloride-induced SH-SY5Y cells injury, which is related with upregulated Cav3.1 protein expression. ..
- Bardai G, Lemyre E, Moffatt P, Palomo T, Glorieux F, Tung J, et al. Osteogenesis Imperfecta Type I Caused by COL1A1 Deletions. Calcif Tissue Int. 2016;98:76-84 pubmed..Three individuals from 2 families had deletions that included also CACNA1G, and these individuals had learning disabilities...
- Yang J, Mamounis K, Yasrebi A, Roepke T. Regulation of gene expression by 17β-estradiol in the arcuate nucleus of the mouse through ERE-dependent and ERE-independent mechanisms. Steroids. 2016;107:128-38 pubmed publisher..Our results suggest that E2B regulates multiple genes through these mechanisms. Of note, Cacna1g and Kcnmb1 channel expression was increased by E2B in WT females only, suggesting an ERE-dependent regulation...
- Ferdous Z, Qureshi M, Jayaprakash P, Parekh K, John A, Oz M, et al. Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat. PLoS ONE. 2016;11:e0153934 pubmed publisher..Gjc1; cell membrane transport, Slc8a1, Trpc1, Trpc6 (4-fold); intracellular Ca2+-transport, Ryr3; calcium channel Cacna1g, Cacna1h, Cacnb3; potassium channels, Kcnj5, Kcnk3 and natriuretic peptides, Nppa (5-fold) and Nppb (7-fold)...
- Emerick M, Stein R, Kunze R, McNulty M, Regan M, Hanck D, et al. Profiling the array of Ca(v)3.1 variants from the human T-type calcium channel gene CACNA1G: alternative structures, developmental expression, and biophysical variations. Proteins. 2006;64:320-42 pubmedWe describe the regulated transcriptome of CACNA1G, a human gene for T-type Ca(v)3.1 calcium channels that is subject to extensive alternative RNA splicing...
- Wang S, Wang P, Gao F, Li Q, Liu Z, Fu X, et al. [Decreased mRNA expressions of T-type channel alpha1H and alpha1G in the sperm of varicocele patients and their implication]. Zhonghua Nan Ke Xue. 2012;18:331-4 pubmed
- Maasalu K, Laius O, Zhytnik L, Koks S, Prans E, Reimann E, et al. Featured Article: Transcriptional landscape analysis identifies differently expressed genes involved in follicle-stimulating hormone induced postmenopausal osteoporosis. Exp Biol Med (Maywood). 2017;242:203-213 pubmed publisher..Further statistical analysis identified a potential osteoporosis mRNA biomarker pattern consisting of six genes: CACNA1G, ALG13, SBK1, GGT7, MBNL3, and RIOK3...
- Chemin J, Taiakina V, Monteil A, Piazza M, Guan W, Stephens R, et al. Calmodulin regulates Cav3 T-type channels at their gating brake. J Biol Chem. 2017;292:20010-20031 pubmed publisher..Our findings may have implications for arrhythmia disorders arising from mutations in the gating brake or CaM. ..
- Bezençon O, Remen L, Richard S, Roch C, Kessler M, MOON R, et al. Discovery and evaluation of Cav3.1-selective T-type calcium channel blockers. Bioorg Med Chem Lett. 2017;27:5322-5325 pubmed publisher..2- and Cav3.3-channels. This compound displays poor DMPK properties, making its use difficult for in vivo applications. Nevertheless, this compound as well as analogous ones are well-suited for in vitro studies. ..
- Thuesen A, Andersen K, Lyngsø K, Burton M, Brasch Andersen C, Vanhoutte P, et al. Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice. Pflugers Arch. 2018;470:355-365 pubmed publisher..Changes in NO levels are involved in this phenomenon in WT and Cav3.1-/- mice. These findings suggest that T-type channels play an important role in age-induced endothelial dysfunction. ..
- Bertolesi G, Jollimore C, Shi C, Elbaum L, Denovan Wright E, Barnes S, et al. Regulation of alpha1G T-type calcium channel gene (CACNA1G) expression during neuronal differentiation. Eur J Neurosci. 2003;17:1802-10 pubmed..1 Ca channel gene, CACNA1G. We identified two putative promoters (A and B) in 1.3 kb of cloned genomic DNA...
- Kim T, Choi J, Kim S, Kwon O, Nah S, Han Y, et al. The biochemical activation of T-type Ca2+ channels in HEK293 cells stably expressing alpha1G and Kir2.1 subunits. Biochem Biophys Res Commun. 2004;324:401-8 pubmed..1 cell line would have potential uses in the study of T-type Ca(2)(+) channel-mediated signaling pathways and possibly useful in the development of new therapeutic drugs associated with T-type Ca(2)(+) channels. ..
- Strom S, Stone J, Ten Bosch J, Merriman B, Cantor R, Geschwind D, et al. High-density SNP association study of the 17q21 chromosomal region linked to autism identifies CACNA1G as a novel candidate gene. Mol Psychiatry. 2010;15:996-1005 pubmed publisher..Markers within an interval containing the gene, CACNA1G, were found to be associated with Autism Spectrum Disorder at a locally significant level (P=1.9 × 10(-5))...
- Ohkubo T, Yamazaki J. T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells. Int J Oncol. 2012;41:267-75 pubmed publisher..1 knockdown blocked cyclophosphamide-induced apoptosis. These results suggest that Cav3.1 channels may contribute to the repression of tumor proliferation and the promotion of apoptosis mediated via Cav3.1-specific Ca2+ influx. ..
- Lopin K, Gray I, Obejero Paz C, Thevenod F, Jones S. Fe²? block and permeation of CaV3.1 (?1G) T-type calcium channels: candidate mechanism for non-transferrin-mediated Fe²? influx. Mol Pharmacol. 2012;82:1194-204 pubmed publisher..1 channels exhibit a significant "window current" at that voltage (open probability, ?1%), Ca(V)3.1 channels represent a likely pathway for Fe²? entry into cells with clinically relevant concentrations of extracellular Fe²?. ..


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Infection Control Principles and Practices for Dental Settings
For dental health professionals who must meet infection control training requirements for professional credentialing or licensure.
Infection Control & Barrier Precautions for New York State Licensed Health Professionals
For health professionals who must meet infection control training requirements for professional credentialing or renewal of a New York State license.
Principles of Infection Control for Child Care Professionals
Training in principles of infection control specifically for professionals in child care settings such as day care centers and pre-schools.
Courses designed specifically for personnel responsible for coordinating infection control and patient safety programs in ambulatory surgical settings.
A Primer for Designated Infection Control Managers in Ambulatory Surgical Settings, 4th Ed
A primer in principles and practices that are widely accepted as the foundation of a successful infection control program in the ambulatory surgical setting.
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Using an Infection Control Risk Assessment to Create an Infection Control Plan for an ASC, 5th Ed.
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Administration of Moderate Sedation and Analgesia: Keeping the Patient Safe, 4th Ed.
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Moments with Missy™ initially started as a small Facebook group. It was birthed as a result of Melissa (Missy) giving her pain a voice and from a desire to help other people move beyond their pain, toward healing and hope. Missy would discuss her life experiences and struggles along with what she was doing to positively deal with them. In 2015, the group became an official brand. Moments with Missy™ became a platform for empowerment, hope and healing, designed to provide positive insight on everyday issues. The goal is to help people better cope with life by teaching them how to reconstruct their thinking processes so that they learn to thrive despite difficulties.
Missy combines her Psychology degree, experience servicing the mentally ill, personal history of depression and struggle with suicide with her faith in God to make Moments with Missy™ the life-changing presence that it is.
Through various workshops, paneled discussions, empowerment sessions, individual coaching, relationship advocacy, her published inspirational memoir, MsMissy Speaks, and her blog, Missy has been able to support and encourage those struggling with depression, sadness, unhealthy relationships and poor life quality. She is skilled in sharing her traumas, wounds, and present difficulties to connect with and inspire others who want to transition from surviving to thriving. Missy loves to empower individuals to take control of their life and relationship choices by teaching them to be in tune with themselves (such as their wants, needs, fears, strengths, and what makes them happy). Missy specializes in helping individuals evaluate their relationships and determine whether or not they are healthy and serve a positive purpose.
Moments with Missy™ is designed to be a reminder that no one has to be alone. We all go through extremely difficult times. We all face discouragement and at some point will want to give up. We all need help and hope. Each of us has a past. We are flawed. We all have something about ourselves or our lives that we don't want people to know. The more amazing truth is that we are all capable of surviving and learning and growing through the difficulties.


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For your consideration, a Brutalist candleholder sculpture in welded brass by the noted 20th century architect and designer Robert Stanton (1900-1983). The work is in excellent condition and measures 19.5cm tall and 7.5cm in diameter. The work features impeccably modernist aesthetic and displays a rich patina. Signed "R. Stanton" "74".
Robert Stanton (1900-1983) was an American architect. A resident of Carmel, California, he practiced primarily in the central California coastal region, and was responsible for a variety of eclectic buildings, most notably the Monterey County Court House and the King City Union High School, both listed on the National Register of Historic Places. He worked closely with sculptor Joseph Jacinto Mora on several of his projects. Stanton was born in Detroit, Michigan in 1900. His mother was a singer in the B.O. Whitney Opera Company. Stanton joined the U.S. Navy during World War I, afterwards graduating from the Manual Arts High School in Los Angeles, CA. From there he went on to architectural studies at the University of California, Berkeley, where he was involved in theater productions. Following his studies he went on a grand tour of Europe. On returning to the United States he worked in Pasadena, CA for architect Wallace gaining licenses for architecture and real estate. In 1935 Stanton opened his own office in the Del Monte Hotel in Monterey establishing a practice that included school and hospital work in the Monterey area and across the San Joaquin Valley. In addition to the Monterey County Court House and King City High School Auditorium, Stanton designed schools in Monterey, the San Benito County Hospital, the Salinas General Hospital and buildings at Fort Ord.
Circa 1970's Brutalist Candle Holder by Modernist Architect, Robert Stanton (1900-1983)
4 other shoppers are interested in this item
since 2012


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Jessica dee photo
Jessica Dee Stewart I found on Findagrave. Clark Berry Stewart — Support new devices and other languages. Taneka Sky Photography Photographer. Managed by Kate Public Figure.
I felt very comfortable, and the results were absolutely be
Jessica Dee Photography
The flower will remain visible until an administrator has reviewed it. Santec Home Services Cleaning Service. Are you sure that you want to delete this photo? Grow in Grace Photography Photographer. We need to update the site to:


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By Chitranjan Sawant
Rejoice ye all captains and commoners! Lord Ram has returned to Ayodhya after a fourteen-year exile. It is an extra-ordinary homecoming indeed. The ghost of evil personified by Ravana and his tribe is laid to rest for good. Peace prevails all over. Let us light lamps and illuminate home and hearth. The illumination is done well. It is being done year after year. Rejoicing returns on Diwali to lift low morale generated by depression, both mental and mundane; not ignoring the economic one.
Lighting the lamp of true knowledge to dispel darkness of ignorance looming large on our minds is the need of the day. `Tamso Ma Jyotirgamaya' (Lead me from darkness unto light); so prays the devotee to God. The prayer mantras seeking light are recited in broad daylight. Does one pray for light of the day during daytime when sun is shining bright? Certainly not. Without emphasizing the obvious we may say that it is the inner darkness that needs to be dispelled. When the pall of ignorance envelops the inner self, and the individual loses his sense of direction, his mind becomes numb and he loses his mental equilibrium. He fails to tell what is right and what is wrong. He becomes aimless and rudderless. He is caught in the whirlpool of false beliefs and superstitions leading to observance of meaningless rituals. Eventually he sinks into the dark abyss.
How can a fallen man be resurrected? How does a human being come out of the darkness and proceed towards light to lead a meaningful life? The process is simple and the goal achievable. Well, the spouse or mother of the fallen person is most suited to be an instrument of resurrection. The spouse or mother is a friendly critic who does constructive criticism with an eye on betterment of lifestyle. Kabir, the unschooled pragmatic preacher advises householders to provide free board and lodging to a critic in the courtyard of the main house because the critic would effect an improvement in the householder's behavioural pattern without using pungent detergents. Apparently the modus operandi would be proactive persuation. Aim is to let the reformed person lead a happy life after corrective measures have been taken.
Further the atheistic tendencies of the fall guy should gradually change to unflinching faith in God. The Almighty is the prime source of inspiration and guidance of one and all. When men and women pray to Him, He listens and responds to prayers. Of course prayers should not be destructive and revengeful in nature. Let us not pray for the demise of an enemy or destruction of an adversary's property. One should not expect God to be a collaborator in crime against humanity. A prayer is a `prarthana' after an individual has done `purushartha' (taken action to accomplish task) and supplements it with a logical and reasonable prayer to achieve the goal. Thus the `Purushartha' is followed by `Prarthana' and not vice-versa. A `prarthana' bereft of `purushartha' may not yield results.
When a person chants a Ved Mantra , meditates and prays to the Supreme Being, that meditating persons is on way to imbibing the great qualities of the Almighty. The Vedic word for this process is `Upasana' – taking a seat near Him , speaking metaphorically. Through Upasana, a soul enlightens itself and does not let darkness envelope it at anytime anywhere. Such a soul becomes the enlightened one and stays enlightened, unhampered by abysmal darkness. Let nothing on earth dampen or darken the inner spirit. Remain upbeat always and every time. For the enlightened ones, it will be Diwali by day and Diwali by night the year round.
We may dive deep into history and resurrect an earth-shaking event of the nineteenth century India.It happened at Ajmer in Rajasthan. A 59-year old Sanyasi lay dying in the Bhinaya Kothi.He had revolutionized the study of the VEDAS by writing Ved Bhashya in both Sanskrit and Hindi.He had made the Celestial Knowledge,Vedas, available to masses by bringing them out of the closet of classes.For centuries the divine revelation was the exclusive preserve of the Brahmin males alone.Even Brahmin ladies were bereft of it. Swami Dayanand Saraswati set the ball rolling for a Renaissance in the teaching-learning process of the divine revelations,Vedas.Many men and women who were not born Brahmins were inducted into the learned class of priests and preachers by the Arya Samaj founded by the great Swami. He lay dying on the Diwali day in 1883.The great seer who had lighted lamps of learning was to see his own lamp of life being extinguished.He grieved Not because as a seer he knew that his Atma (soul) was immortal.
Swami Dayanand Saraswati,who was later addressed as a Maharishi by the Arya Samajists and other devotees,was a religious and social crusader.He ,as a Reformer of not only the Hindu society but of the entire mankind,crusaded against removal of religious and social evils.Thus he attacked citadels of ignorance and middle men who were parasites of the religious and social orders.The Swami made forays into the feudal Rajputana,now called Rajasthan, to reform the semi-independent rulers.The Rajput rulers of States had accepted the British overlordship and were left with no gainful occupation,not even running the administration of their own states.The british Resident and the Indian Dewan used to run the show.The Maharajas drank alcohol,patronized prostitutes and let the social cancer consume the society.The Swami could not stand by as a passive onlooker and made an endeavour to beard the lion in his own den.The vested interests counter-attacked and had him poisoned.After suffering the agony of arsenic-infected body for one month one day,during the period he was shifted fromplace to place by doctors, the Swami knew that his end was near.
Swami Dayanand Saraswati's faith and belief in GOD was firm and absolutely unshakable.Right till his last breath he recited the Ved mantras,sang bhajans and said his prayers in Hindi,notwithstanding infirmity owing to prolonged sickness which was not treated adequately.His praise of God was unbelievably true.What he had preached in his whole life,he practiced till the very end.Among the people who had assembled around him at that time was a young Science graduate,Guru Dutt from the Punjab.He was an atheist in his thinking.Seeing Swami ji's steadfast belief in the Almighty,irrespective of his pain and suffering,the young man from Lahore became a follower of the Vedic Dharma through and through and devoted his entire life to its propagation.The darkness that had enveloped his mind and thought process during his adolescence was dispelled on the Diwali day,thanks to the pragmatic approach of Swami Dayanand Saraswati.The Swami,at the fag end of his last breath said " O God,may thy will be done' and then let his soul leave the body and the mundane world.On the Diwali,30 October 1883,The Swami's lamp of life was extinguished but he had lighted millions of lamps for the entire Mankind.May the Almighty give us ,men and women of the Arya Samaj,the will and courage to carry the torch of the Vedic knowledge forward to illuminate lives of millions of men and women now and for ever.!
Brigadier Chitranjan Sawant, VSM
609, Sector-29
Telefax: 91-120-2454511
Phone: 91-120-2454622 Mobile : 9811173590
E-mail: firstname.lastname@example.com
Very inspiring commentary,
Very inspiring commentary, Sawant ji. Dhanyavad.
Namastey This is the best
This is the best ever gift of Deepawali I have received/read.
My best wishes to you and your family.
Naveen Arya
AUM Anupam Ji avam Navin ji
Anupam Ji avam Navin ji ko Deepawali lekh ki sarahna ke liye dhanyawad.
Brigadier Chitranjan Sawant,VSM


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Way back in 2006, a World Series of Poker event set the world record for the most card game players in a single tournament, under one roof. The final tally was 8,773 participants. Next month, a Magic tournament just might shatter that record.
What tournament is this?
M:TG developer Wizards of the Coast and Channel Fireball are hosting a Grand Prix event in Vegas next month. The event, which will feature the release of Modern Masters 2015, has booked a space that can accommodate 10,000 concurrent players. If the organizers can attract an attendance that's anywhere near capacity, they'll have handedly beaten a world record that's stood for nearly a decade now.
It's a huge gambit, and one that is in no way guaranteed to work, but hype over this new set (which will include some of the game's most coveted cards) is reaching a fever pitch, the organizers are very optimistic.
How likely is it to actually break the record?
Realistically though, the event organizers might have been a bit too optimistic. The current attendance record for a Magic tournament is just 4500 people in 2013. That being said, that record-setting event was for the release of the original Modern Masters set, so if any event can do it, it's next month's Grand Prix.
However, that's not where the story ends. Not only will this Magic event be gunning for the 2006 record, but it will also be competing with a Poker tournament looking to do the exact same thing. To make matters even more interesting, both events will be happening on the exact same weekend.
What's going on in the Poker world?
Despite its continuing popularity, the World Series of Poker has seen declining numbers since the 2006 world record, and in the past few years, they've struggled to even break 7,000 attendees. To breathe some fresh life into things, they've announced a massive tournament called "The Colossus."
The tournament will feature a relatively low (by Poker standards) $565 buy-in, and a guaranteed minimum prize pool of $5 million. Just like Wizard's gamble on their Magic Grand Prix event, The Colossus will be a huge risk for the World Series of Poker. The prize pool is so massive that they'll need to topple their 2006 record to just break even.
With both events betting the farm on some huge attendance numbers, Las Vegas seems like a pretty appropriate venue.
When and where will these events take place?
Both events will be held over the course of a weekend, beginning on May 29.
The World Series of Poker's Colossus will take place at the Rio Hotel and Casino, while Magic's Grand Prix will be held at the Las Vegas Convention Center.


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The main goal of Kazancompressormash is guaranteed high quality of manufactured equipment and provided services.
The company operates in accordance with the contemporary Russian and international standards of management system, which is confirmed by the relevant certificates. Integrated Management System of Kazancompressormash is certified for compliance with ISO 9001:2008, ISO 14001:2004, OHSAS 18001:2007 (quality management system, environmental management and management of occupational health and safety).
The company is currently implementing a project of the quality management system in accordance with requirements of STO Gazprom 9001.
|The certificate of conformity of the integrated management system (IMS) to requirements of GOST R ISO 9001-2008 (ISO 9001:2008), GOST R ISO 14001-2007 (ISO 14001:2004), GOST R 54934-2012 / OHSAS 18001:2007
|The certificate of conformity of the management system to requirements of ISO 9001:2008
|The certificate of conformity of the centrifugal compressors to requirements of the API 617 Standard (part 1-2)


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Table of Contents
Manual Overview
Chapter 1 - Introduction/Planning
Chapter 2 - Mobile Dental Systems
Getting Started
Van Structural Considerations
Vehicle Design
Building and Delivering the Vehicle
How long does it take to build the vehicle?
What schematics and manuals do we need upon delivery?
Can we get technical support and training from the manufacturer?
How do we plan for maintenance of the mobile vehicle?
Program Operations
Chapter 3 - Portable Equipment
Chapter 4 - Mobile-Portable Hybrid
Chapter 5 - Measuring Effectiveness and Outcomes


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People often make the mistake of not getting all the facts on the table before they make a case about the facts. Example: Bible prophecy is often misinterpreted when Christians assume Bible passages must fit into their presupposed eschatology. "Pay no mind to what the Bible says—I've already made up my mind what the Bible means…." Gary DeMar urges viewers to take Biblical facts at face value, and not reorder or redefine the facts to fit your presupposed beliefs.
Podcast: Play in new window | Download (Duration: 10:04 — 2.6MB)


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Zapier Integration
Before you start:
- This integration is an internal part of our Chatbots editor. Zapier is available as one of the actions and can be added to any automation you've created.
- Most zaps send out data collected during the chat to other, 3rd party apps.
Why would I need to use Zapier with Tidio?
This integration will save your time by performing repetitive tasks for you. You can automate workflows which previously had to be done manually with connections called Zaps
With Tidio as the Trigger for Zaps, you'll never have to export contacts from chat manually again.
Build your own custom Zap on Zapier.
1. Create a lead in the CRM of your choice
With the Zapier integration, you can make sure every valuable contact will be sent to your CRM, regardless of it being integrated internally in Tidio!
There is a wide variety of CRMs available out there, and now you can automatically send contacts and leads to every one of them, as long as they are available in Zapier.
What is important is that it will happen automatically, as a part of your automation you use to gather the visitor data.
2. Get an email notification for every incoming message
If you value each and every message you receive from your customers, you don't want to miss on a sales opportunity and want to be extra sure you get the message no matter where you are – use the Zapier integration to be notified about each
3. Improve customer service in your Shopify store.
Tidio integration with Zapier allows you to additionally automate and keep track of usage of Shopify-specific bots: Shipping Zones and Check Order Status.
While both of them provide you with a great value by answering your visitors important questions in no time, they can give you even more insight into your business condition and opportunities.
Shipping Zones Bot is a great indicator of where your potential users are. Keep track of locations you are receiving a lot of questions about and consider offering your delivery right there. You can do that by creating a Zap after the bot has been launched and then sending the information to your email or Google Sheets spreadsheet.
Check Order Status, however, is an excellent way to see if you offer fast enough shipping. If you receive a lot of questions about the order status, you might need to work on how fast your products are delivered to your customers. Just add a "Send to Zapier" action to your bot and from there analyse the number of inquiries in the tool of your choice connected with Zapier.
How to Setup:
It's easy! Just visit your Tidio admin panel and edit any chatbot you wish to add a zap to.
In this example, we'll be editing the Lead Generation bot so that it automatically sends the contact details to MailChimp.
Once you've added the Lead Generation Bot (full guide available here), please edit it:
In the next step, we'll have to add the Zapier node to our automation…
… and follow the integration instructions:
Please follow the instructions – log into Zapier and look for the Tidio app.
Select Tidio Trigger: "Contact Sent From Bot" and click Save + Continue
Paste in the long Integration Key and click Yes, Continue.
Then, from the list of actions, select the node "[node name] (date 20xx-xx-xx 00:00:00)" from the list and click Continue
In the "Pick A Sample To Set Up Your Zap", click Continue:
Now, it's time to set the action step. Here's where thousands of connections become possible.
Let's talk about a popular connection with Mailchimp. The goal here is to automatically populate your mailing list with the contacts collected on chat.
Connect your Mailchimp account in Zapier and start configuring the list.
Make sure to connect all nodes in our editor and save your configuration:
After connecting the
…to receive a new contact in Mailchimp after a few minutes.


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Haines City residents say they weren't notified about sports complex construction
City says notice mailed to residents 300 feet around complex
HAINES CITY, Fla. – Gary and Bobbi Govanus are not pleased with the construction going on behind their Haines City home. They were even more upset when they found out what was being constructed.
"Definitely not what we bought the house expecting," Gary Govanus said.
Balmoral Resort Florida broke ground in 2016.
Phases one and two are complete and include homes, a club house, a bar and a restaurant.
It has a $6 million amenities package, according to developer Garrett Kenney.
"We have had a number of owners visit us and they have been very, very happy with the product they purchased," Kenney said in a promotional video about the project on YouTube.
But many people living along Peninsular Drive are not happy with what's being constructed in phase three.
"We looked outside one day and those lights were going up," Gary Govanus said.
Phase three of the project was originally slated for 64 single-family homes. However, it will now be a sports complex that can be rented to various teams, with three soccer fields surrounded by 24 homes. The complex will also have 10 beach volleyball courts, and 60 foot stadium lights, according to site plans.
"Suddenly we're in the middle of a professional soccer stadium," Gary Govanus said. "This isn't what we signed up for."
The Govanuses and many of their neighbors tell News 6 they were never told of the change.
"They said that they sent us letters and none of the neighbors got them," Bobbi Govanus said. "We open everything from the city and I don't know what happened to it."
Haines City Manager Deric Feacher said he was not available for an interview in time for this story, but emailed a packet of information about the complex to News 6.
Feacher said the developer met the city's notice requirements by mailing 54 notices to adjoining property owners within 300 feet of the project.
He also said an advertisement was placed in a local paper and a notice of a public hearing was placed at the site for others who live in the area.
According to the city, only two homeowners inquired about the proposed changes at those meetings.
"Again, nobody knew," Bobbi Govanus said. "Or they would have been there."
The Govanuses say they have numerous concerns, including, "60-foot lights, the noise, people, the traffic, and just the basic disruption of our life," Gary Govanus said.
The couple said they are also concerned about their property values.
"This is not benefiting anybody except the people who own the academy," Bobbi Govanus said. "And to put it in the middle of a residential neighborhood, I mean, this is definitely residential."
The sports complex is expected to be completed in the fall.
Copyright 2019 by WKMG ClickOrlando - All rights reserved.


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Lights, Camera, Action!
Now you've thought carefully about your storyboards, scripts, models and props (and hopefully done some planning and preparation!) you're ready to start shooting your film!
The previous sections of this site should already have given you lots of ideas of how to go about shooting your film such as thinking about The Grammar of TV and Film, following these Film Making Tips or considering this guide on How to Make a Film.
When you're shooting your film, make sure you have considered:
- Which equipment is best for the job: a camera is essential and a tripod is often an advantage too! A mobile phone or still camera will let you take some footage but the quality may not be very good if you're shooting a 'live' film. There are lots of inexpensive digital video cameras and tablets which will do a great job (and even record in HD!) so see what you have in school or at home. Whichever camera you choose, make sure you practice before you want to use it for some serious film making.
- Roles and responsibilities: It's often useful to give individual people in your 'film crew' different responsibilities. You can swap these around whenever you like so that everyone gets a turn doing something different. Why not give everyone a role and a badge to wear to remind them what their job is (this really cuts down on arguments and disagreements too!). Think about roles such as:
- Director
- Sound leader
- Continuity leader
- lead animator (if making an animation)
- Lighting leader
- camera leader
- Script editor / checker
- How to orgainse your shoot: your audience will need to watch your film in the correct order, but that doesn't mean you need to film it in that order! When films involve several costume changes, scenery changes or changing characters, it's often best to film in a different order to the one you will finally present it in!
- The best angle to shoot from: shooting from a low angle can make your characters look strong and powerful whilst shooting from a low angle can make them look weak and insecure.
- How (or whether!) to move your camera during a scene: what effect does this have on the scene? Will you zoom or pan? Try different techniques and see which one gives you the effect you want.
- Continuity: Make sure your characters don't suddenly change clothes or hairstyle part way through a scene, ensure animated characters move gradually and not suddenly, and, if you're splanning to stich scenes together, make sure they're going to flow from one to another.
- Sound, sound, sound! Your audience will often forgive poor visuals but not poor sound! if they can't hear what's going on then your film becoems really difficult to watch! Read the 'Adding Sound' section on this webioste for more tips on this.


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Ilm-e-Takhreej-e-Hadis se Dilchaspi Rakhanay Walay Doston Kay Liye Aik Jamay Software
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Classic fashion house Timberland brings this winter ready hat to complete your young man's outfit. Made from pure cotton, this kid's Timberland hat has a red, white and light grey colourblock style with soft white pattern detailing, and the label's namesake logo woven in navy around the middle. Finished with a large grey pom pom on the top, and a ribbed turn up brim.
We are currently experiencing a high volume of orders due to being in
Winter Sale, orders may take a little longer to dispatch.
Items will normally be ready for collection within 24 hours from our Sunderland store.
Click here to for full delivery details.
All orders must be placed before 2pm GMT (Monday - Thursday) to qualify for Next Day Delivery options. Saturday & Sunday deliveries orders by 2pm Friday.
We currently ship using a combination of couriers including DPD, Royal Mail, Aramex and Fed Ex depending on the delivery destination.
From the first time you shop with us and create an account at Designer Childrenswear you will be automatically inducted into our exclusive DC Rewards programme.
Every £1 you spend with us you will receive 5 points. Points determine the level you are assigned and the access you have to exclusive rewards.
Also when you spend £100 or more with us we will send you a £5 gift voucher to spend with us on your next order. One voucher per order can be used and minimum spends apply.
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