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Crushing Brucellosis In Central Asian Republic
TAJIKISTAN - A dramatic decline in brucellosis, a serious disease affecting both livestock and humans in this Central Asian country, is being hailed as the first major victory of the recently privatised national animal health service. Government services in this former Soviet republic all but collapsed during a civil war in the 1990s and by 2004 brucellosis infected 8.5 per cent of the country's vast sheep and goat herds. Meat and dairy production declined and people who caught the disease from consuming unpasteurised milk and cheese became debilitated with chronic fevers, muscle pains and weakness.
The situation has turned around, with disease rates now around 2.5 percent, thanks to a nationwide campaign that marshalled the country's veterinarians into a Tajikistan Veterinary Association, now with 1 000 dues-paying members, upgraded their skills and developed a network of veterinary drug stores and small clinics. From there, 1.7 million animals were vaccinated.
Although the initial emergency phase of the campaign was subsidized by the European Union and Sweden through FAO projects, the key to sustainable privatisation was the decision to phase out subsidies. Now farmers pay for every vaccination in full, a big change in thinking after decades of free medical care under the communist system.
International donors and FAO were determined to foster self-reliance in the country. They did not want merely to substitute aid dependence for government dependence.
"We explained from the beginning that one day the project would end and the cost of vaccination would be covered by the farmers themselves," says Karomattulo Khamroev, a national consultant and senior veterinarian who has worked with FAO for the past 11 years.
Rahmonali Ashurov is the chief vet for a sub-district near Kulyab, a city that has traded in livestock since the ancient days of the Silk Road. Standing with Dr Khamroev in a field full of sheep, he sums up the local situation at the moment: "The private sector is thriving and the number of animals in our area increases year by year. The latest blood tests show that we have no brucellosis in this region."
One of the major comparative advantages of the UN system is its neutrality. Agencies work systematically and freely across national borders. FAO has been able to spread the lessons learned in its privatization efforts and disease campaigns elsewhere in Asia.
"Last year we had a regional workshop in Dushanbe where people from Georgia, Armenia, the rest of Central Asia, even from Jordan and Turkey, came to look at how FAO has handled and dealt with brucellosis control and what lessons and best practices they can take back with them to their own countries," says Nassim Jawad, Coordinator, FAO Coordination Office in Tajikistan, adding that Tajik specialists were also travelling to neighbouring countries to share their knowledge.
Mr Jawad, a native of Afghanistan, just across the Tajikistan's southern border, knows the sub-region well and brings international linguistic skills to his task. Dari, his mother tongue, is related to the Tajik language so that he communicates effortlessly with his staff and the government. His main work now is to facilitate government reform in the agricultural sector.
"We are the lead technical agency in the reform process," he says. "We have been tasked with all six working groups in the sector: agriculture, water, land reform, governance, alternative financing and social protection of rural areas."
"We meet with the working groups once a week and every other week we bring together the donor agencies and the government agencies," he says. "The government side is chaired by the deputy prime minister, the donor side by myself. We discuss the progress of the reform, we discuss bottlenecks, we discuss issues."
The government in this remote country has already changed laws on animal quarantine and seed production to meet international standards.
Shukrullo Rahimnazarov, Deputy Minister of Agriculture, describes the state of play this way: "We no longer have a state sector in Tajikistan agriculture. Our work is only to support the private sector, which has a significant role to play in our goal to reach food security."
TheCattleSite News Desk


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Guitarist Australia Magazine
Guitarist Australia Magazine Review Voyage Air VAD-2
It folds, but how does it sound? by Kris Petersen
"…As far as acoustic guitars go, the Voyage Air is a great instrument. It has everything you would expect of a guitar in its price range and more. While the folding down of the guitar would appear to be a gimmick, the quality of the tones created and the craftsmanship gives it a clear advantage over other acoustics in its class.
The Voyage Air has really challenged what we previously believed constituted a good acoustic guitar. Having the ability to fold an acoustic in half to make it more portable is a clear cut advantage for the travelling musician. The fact that the guitar sounds and plays great as well makes this one instrument that you have to check out.
Our preconceptions about how it might sound were not only challenged but completely destroyed…

subset: commoncrawl


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I'm using Ubuntu 11.10 in a VirtualBox VM on a MacBook Pro with the default Unity UI. Positioning the mouse cursor over the 1-pixel wide border to resize a window is driving me absolutely nuts. Lots of people have asked the same question but all the advice I've found for fixing this doesn't seem to work:
In System Settings > Appearance, there are four themes (Ambiance, Radiance, HighContrast, HighContrastInverse), all of which have exactly the same size resize border.
Installing other packages (e.g. human-theme) has no effect on the theme selection.
My laptop doesn't have a middle mouse button, and even if it did, I don't want to use two hands to press Alt + middle button just to resize a window. In an attempt to change the resize key binding, I installed compizconfig-settings-manager and ran ccsm. Any changes I make to the Initiate Window Resize binding in the Resize window plugin have no effect. In fact ccsm seems to do nothing at all.
I discovered that the previous issue is because I'm using Unity 2D instead of Unity (3D), even though I'm picking the non-2D desktop when I log in. Unity 2D has no equivalent of ccsm as far as I can see. And when I configure VirtualBox so that the 3D Unity starts up, I get completely screwed up window behavior (missing all borders, don't accept mouse clicks, etc.). Sigh.
Help please!
I hate to use the M word, but on the Mac all windows also have a 1-pixel visual border, but the invisible resize border is actually usable (it's at least 8 pixels wide on the edges, plus a nice big rectangle in the lower-right corner). I don't think implementing usable resize behavior should be up to each individual theme; this is a lower-level functionality issue and should work right in every theme. What's the right package to file a bug against for this?


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Hilton Head and Bluffton Home Selling Made Easier!
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These low cost strategies to make your Hilton Head and Bluffton home more appealing are sure to have your potential buyers saying WOW! Plus these tips are quick and easy.
- Mow the lawn and trim the bushes - especially the ones that block your windows and diminish sunlight.
- Purchase a new doormat.
- Add a bright pot of flowers (or even a small evergreen in winter) on your front porch.
- Replace any old, tarnished doorknobs on your doors and polish or replace your house numbers.
- Power-wash your driveway, sidewalk, and the exterior siding of your home.
- Edge the grass around walks and trees plus add fresh mulch to your planting beds.
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Looking for a book to read for fun? Check out the library's Recreation Collection in its NEW temporary location on the short bookshelves between the computer banks on the 1st floor. The collection will live here during the construction of the new library cafe this winter.
As always, you can browse the Recreation Collection online, too. And if you're just not sure what you want to read next, let us help! Fill out this short form and your WOU librarians will get back to you with a book or two you might like.
Happy Reading!


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It was looking like another one of those sad interleague rivalry evenings, with the Dodgers' offense appearing impotent (Bobby Abreu, Adam Kennedy, Juan Uribe, and Tony Gwynn in the 5-though-8 holes went a combined 0-for-13), and the Angels just mustering enough to skate to a 2-1 lead with two out and two on in the bottom of the eighth.
Enter Andre Ethier, who followed up a non-descript afternoon with a game-tying single to right, scoring Dee Gordon from second. The next batter was Juan Rivera, and he smoked one to left to score A.J. Ellis and Ethier, putting the Dodgers up 5-2 and icing the game. Kenley Jansen came in to pitch the ninth (2 Ks).
Mike Trout of the Angels, who killed us last night, went 0-for-4 with 4 LOB--allowing me to write this PGT headline. Thanks, Mike!


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On his blog today Sameer looks at a method for finding duplicate code in your applications with the help of PHPCPD.
Duplicated code in projects is a frequent thing and also the one ripe for factoring out in a new class or function. Cut/Paste coding is a common development practice among programmers, a lot of which can lead to code size increase and maintenance nightmares. PHPCPD (php copy paste detector) is a PEAR tool that makes it easier to detect duplicate code in php projects. Below is a short tutorial on the PHPCPD package.
You can either install the tool via a PEAR channel or directly from the github site. Once its downloaded and extracted you can immediately run it on the subdirectory of your choice. He also includes a more extended example - a search on a minimum of 5 lines of 70 tokens found to trip the filter in finding cloned functionality.


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A district of southern Italy, the limits of which have varied. It is usually regarded as the region bounded by the Frentani on the north, Samnium on the west, Calabria and Lucania on the south, and the Adriatic on the east. Apulia is now one of the poorest provinces of Italy, but in the Middle Ages, by reason of its several excellent seaports, it was of considerable commercial importance. This probably accounts for its early attractiveness to Jewish immigrants; for in northern Italy commerce had been monopolized by a number of native Christian families. It is impossible to determine the exact date of the settlement of Jews in Apulia, though it must have been early. In Pozzuoli, in the neighboring province of Naples, which was the chief Italian seaport for Oriental commerce, there were Jewish inhabitants about the year 4
The catacombs of Venosa, in Apulia, the birthplace of Horace, have yielded to recent excavators a great deal of epigraphic material, consisting of inscriptions in Greek, Latin, and Hebrew, dating, according to the conclusions of Mommsen, from the sixth century. Seven Hebrew epitaphs of the ninth century, likewise, have been unearthed at Venosa, and their contents indicate the existence of a flourishingcommunal life among the contemporary Jews of Apulia, seeing that in one of them a certain R. Nathan b. Ephraim is eulogized as "an honored man, master of wisdom, chief of an academy, and leader of his generation "(Ascoli, "Iscrizione," p. 71).
"Chronicle" of Ahimaaz.The commencement of the settlement of Jews in Apulia is surrounded by legends. Yosippon, for example, traces them back to the five thousand captives transplanted by Titus from Palestine to Taranto, Otranto, and similar places. The most important contribution, however, to the early annals of the Apulian Jews has been obtained in recent years from the unique "Chronicle" of Ahimaaz ben Paltiel. The attention of Ahimaaz, as regards Apulia, was almost entirely confined to the community of Oria, to which his family had belonged, and the members of which he also regarded as the descendants of the captives of Titus. It was in Oria that the patriarch of the family, Amittai, became known about the middle of the ninth century, both as scholar and liturgical poet. In the age of his two sons, Shephatiah and Hananeel, the former of whom became particularly distinguished for his literary and communal activity, there appeared on the scene of Italian Jewish life the figure of Aaron the Babylonian. Under his influence the academies of Oria are alleged to have sprouted forth in unprecedented vitality, and the various branches of Jewish law and life to have burst into new activity.
Eastern scholars probably were in the habit of visiting the flourishing communities of the Occident for the purpose of transplanting thither the traditions of scholarship and religion. Such a scholar is reported by Ahimaaz to have come to Venosa. He made it his practise to deliver public lectures every Sabbath, basing his expositions on the Midrashic interpretations of the weekly Scriptural sections. His lectures were given in Hebrew probably, as the services of an interpreter were needed to render them intelligible to the audience.
Thaumaturgy and Poetry.Poetic and thaumaturgic talents were the favorite attributes bestowed by tradition on the Jews of medieval Apulia. Both are ascribed by Ahimaaz in a great measure to R. Shephatiah b. Amittai, whom illinformed commentators had regarded as one of the captives of Titus and one of the authors of "We-hu RaḦum," a liturgic piece, but who probably flourished in the second half of the ninth century in Oria. According to the testimony of Ahimaaz, it was Shephatiah's argumentative ability and miracle-working power that had saved the Jews of Oria from a serious religious persecution.
Synchronously with this persecution occurred a disastrous Arabian invasion of Calabria and Apulia. In the year 872 Saudan, an Arabian conqueror, entered Bari, where he usurped the government and established a court, in which, as legend has it, Aaron the Babylonian was accorded boundless honors as counselor and oracle just prior to his departure for the East. From Bari, Saudan advanced upon Oria, to which he made the proposal of a siegeless settlement on condition of a certain voluntary tribute from the population. Here, again, Shephatiah, whom legend presents as the disciple of the wondrous Aaron, and who probably was familiar with the Arabic language, was delegated to negotiate with the invader. The Saracen terror, however was frustrated by the confederacy of the emperor Basil I. with Louis II., the emperor of Germany.
That the conversion of the Jews was a prevalent ambition in Apulia in that age, is inferred, further, from what Ahimaaz records regarding Hananeel, the younger brother of Shephatiah. He says that Hananeel, too, was a noted miracle-worker and liturgical poet; that the archbishop of Oria summoned him to his palace on one occasion, and forced him into a religious dispute, in the course of which the archbishop impeached the correctness of the Jewish calendar with a view of inducing him to accept Christianity.
Astrology.Astrology, also, was cultivated in Apulia. Palṭiel, the son of Cassia—the great-granddaughter of Hananeel b. Amittai—owing to his distinction in astrology, became the intimate friend and counselor of the calif Abu Tamim Maad (called Muizz lidin-Allah or Almuizz), the conqueror of Egypt and builder of Cairo. The friendship between the two, according to Ahimaaz, had begun in Italy on the occasion of one of the Apulian invasions led by Almuizz when Oria was besieged and taken. This emigrant from Apulia had certainly achieved communal distinction among the Jews of Egypt in the second half of the tenth century, since the title of "Naggid" is mentioned in connection with his name.
A cousin of Palṭiel, Samuel b. Hananeel (died 1008), settled in Capua, where both he and his son Palṭiel (988-1043) attained prominence as communal benefactors and leaders. It was Ahimaaz, the son of the latter, born in 1017, who not only returned to the ancestral dwelling-place in Oria, but also left a number of liturgic pieces, and rescued from oblivion the memory of his ancestors. His "Chronicle" mentioned above, being one of the very few literary monuments of that period, is of assistance in forming an idea of the literary fashions and influences of his age. Of course, the influence of the Apulian vernacular shows itself in many peculiarities of expression characteristic of the "Chronicle."
Shabbethai Donnolo.Even prior to the discovery of the "Chronicle" of Ahimaaz, however, Apulia had the distinction of being considered the birthplace of the first Jewish scholar in Europe whose name had been inscribed in the history of literature, Shabbethai Donnolo. This noted physician and astronomer was born at Oria, in the district of Otranto, in the year 913. When he was twelve years old (925) an army of Fatimite Mohammedans, led by Ja'far ibn Ubaid, again invaded Calabria and Apulia, on which occasion, according to Donnolo's autobiographic note, the city of Oria was sacked, "ten wise and pious rabbis," whose names are given, and numerous other Jews, were killed, while a multitude of survivors, including himself, were taken captive. One of the victims was Ḥasadiah b. Hananeel, nephew of Shephatiah b. Amittai, to whom Donnolo refers as a relation of his grandfather ("Ḥakmoni,"ed. Castelli, Hebr. part, p. 3). Several details of Donnolo's life throw light on the condition of Jewish culture in his time and country. Donnolo, for example, like his contemporary Palṭiel, had become a devotee of astrology; but in all the surrounding provinces not a single Jewish scholar could be found able to interpret the astrological writings which avowedly had been copied by him from ancient Jewish works. It is interesting, however, to note that Donnolo had no hesitancy in seeking the instruction of Christian masters in matters of which the Jews were ignorant. This circumstance attests the early origin of that intimacy of relations for which Jewish and Christian scholars have been noted in Italy, and their frequent interchange of thought.
Intellectual Relations with Christians.Donnolo, besides being private physician to the viceroy of southern Italy, was intimately acquainted with Nilus the Younger, the abbot of Rossana and Grotta Ferrata, to whom, on a certain occasion, he appears to have introduced another Jewish scholar. The latter attempted to draw the abbot into a religious controversy, which was, however, adroitly evaded by him. It is one of the first discussions of this character recorded in the European history of the Jews; and its significance lies in the aggressive part taken in it by the Jew, in contradistinction to the one into which, as stated above, Hananeel had been forced. Donnolo's allegorical method of exegesis adopted in his commentary on the mystic "Sefer Yeẓirah" (Book of Creation), as well as his knowledge of the Greek language displayed in it, also testifies to his intercourse with Christian scholars, among whom allegorism was highly popular, and whose spoken language, according to Mommsen, was very closely related to the Greek.
That there was an abundance of Jewish scholars in Apulia toward the end of the tenth century (according to Grätz, but in 750 according to Ibn Daud) is learned, furthermore, from a well-known legend alluding to that age. Four rabbis, as stated by Ibn Daud ("Sefer ha-Ḳabbalah," ed. Neubauer, in "Medieval Jew. Chronicles," i. 67 et seq.), were on a seavoyage from Bari to Sebasteia, when their ship was overtaken by an Andalusian pirate (the admiral Ibn Romahis), and the scholars were made captive, the latter being in the end sold in several cities of Africa and Spain, where each rabbi ultimately became the founder of a Talmudic academy. The real origin and purpose of these traveling rabbis have been variously interpreted, but the historicity of the incident narrated by Ibn Daud can scarcely be doubted. The legend points distinctly to the fact that toward the end of the tenth (?) century certain rabbis emigrated from southern Italy and established schools in various Jewish communities in Africa and Spain (compare Ḥushiel b. Elhanan).
Centers of Learning.Bari was particularly popular as a center of Jewish learning, as is witnessed by the fact that in the eleventh century, R. Nathan b. Jehiel, the author of the "'Aruk," made a pilgrimage thither to hear the lectures of R. Moses Kalfo (compare Kohut, "Aruch Completum," Introduction, p. 15), and that in the twelfth century the religious authority of the Apulian rabbis had been so firmly established even abroad, that in France the proverb came into vogue, in allusion to Isa. ii. 3: "Out of Bari goeth forth the law, and the word of God from Otranto" (Jacob Tam, "Sefer ha-Yashar," 74a). Benjamin of Tudela, who in the latter part of the same century traveled through Apulia, found flourishing Jewish communities throughout the province, Trani possessing 200, Taranto 300, and Otranto 500 Jewish families, while in the port of Brindisi ten Jews were engaged in the trade of dyeing.
During the renaissance of Talmudic learning in the thirteenth century, Apulia still had the good fortune of bringing forth one of the most noted Jewish savants of the age, in the person of
Fra Giordano da Rivalto, in one of his sermons preached in the year 1304, alludes to a general conversion of Apulian Jews that, it was alleged, had taken place about the year 1290, in consequence of a ritual murder with the commission of which they had been charged. The king, Charles I. (1284-1309), is alleged to have left them the choice between baptism and death, whereupon, it is said, about eight thousand embraced Christianity, while the rest fled from the country. The proportion of truth in this statement is not ascertainable. Güdemann denies the assertion altogether on the ground of the friendly disposition toward the Jews manifested by Charles I., though he admits that, in the year 1302, certain property in Trani that had formerly been used as a Jewish cemetery was usurped by the Dominican Order, and that about that time several Jewish synagogues in the same city were converted into churches.ertain, however, it is that in the thirteenth and fourteenth centuries there were Jewish inhabitants in Trani as well as in the rest of Apulia; wherefore Giordano's statement concerning their wholesale apostasy or emigration must be regarded at least as exaggerated, unless, indeed, under improved circumstances, a return of the Jews had occurred.
In the sermons of another preacher from southern Italy, Roberto da Lecce, who flourished in the first half of the fifteenth century, there are allusions to friendly relations between Jews and Christians. That Apulia, however, had gradually lost its prominence as a center of Jewish learning, can not be gainsaid. In the early part of the sixteenth century, for example, there was in Constantinople a whole congregation consisting of Apulian immigrants, who exhibited, however, little of the Italian enlightenment, in that they were the leaders in an abortive attempt to exclude the children of the Karaites from the Rabbinite schools, and to build up a wallof separation between the two Jewish sects—a stroke of fanaticism thwarted by
- Ahimaaz, Sefer YuḦasin ("The Book of Genealogy"), in Neubauer's Mediev. Jew. Chron. ii. 111;
- Ascoli, Iscrizione Inedite di Antichi Sepolcri Giudaici del Napolitano, etc.;
- Lenormant, La Catacambe Juive de Venosa, in Rev. Et. Juives, vi. 200-207;
- Neubauer, The Early Settlement of the Jews in Southern Italy, in Jew. Quart. Rev., 1892, iv. 606-625;
- Güdemann, Gesch. des Erziehungswesens und der Cultur der Juden in Italien, pp. 2, 16 et seq., 184 et seq., 260, 265 et seq.;
- Grätz, Gesch. der Juden, 3d ed. iv. 359, v. 292 et seq., vi. 239, ix. 30 et seq.;
- Schürer, Gesch. 3d ed., iii. 37;
- Schechter, A Letter of Chushiel, in Jew. Quart. Rev. xi. 643 et seq.;
- Zunz, G. V. 2d ed., pp. 375 et seq.;
- Kaufmann, Die, Chronik des Ahimaaz von Oria, in Monatsschrift, 1896, xl. 462-473, 496-509, 529-554.


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[Image by SarahVlad]
A few years ago, in the midst of severe chronic illness (still ongoing), my domain name was poached away from me under extremely dubious circumstances - circumstances that my original provider is yet to fully explain or apologise for - I'm clearly not holding my breath!
In the meantime however, I have sporadically asked for the 'going rate' on my very specific, quite undesirable AU$10 .com domain, and as of today I have been told it is still at more than AU$900.
So please, if you happen to have linked to my site or added me to your bookmarks, or even to have supported me at any stage in the past 8 years, please do NOT do so via thatunreliablegirl.com any further - my website now is thatunreliablegirl.blogspot.com and I greatly, GREATLY appreciate every single visit and link. Please let the "owners" of my rightful domain see their stats drop daily, as they attempt to hold my domain to ransom.
If you do not want to let the shady 'domain brokers' win, please also consider helping me by sharing this post and spreading the word to update any links, and sending the love to the rightful owner of the name.
I am proud of what I have built up over the years and although I have recently been too unwell to keep the site going in earnest, I still hope to one day (soon!) relaunch it with all the energy, enthusiasm and inspiration I was once able to muster. I just need your help first!
Thank you!


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TEL-AVIV, Israel, Nov. 10 (Korea Bizwire) — RedHill Biopharma Ltd. (NASDAQ:RDHL) (TASE:RDHL) ("RedHill" or the "Company"), a biopharmaceutical company primarily focused on the development and commercialization of late clinical-stage, proprietary, orally-administered, small molecule drugs for gastrointestinal and inflammatory diseases and cancer, today announced that it has concluded a positive Type B Meeting with the U.S. Food and Drug Administration (FDA) discussing the chemistry, manufacturing and controls (CMC) aspects of the RHB-105 Phase III development program. RHB-105 is a proprietary, fixed-dose, oral combination therapy for the eradication of H. pylori infection.
Subject to final minutes of the meeting, the FDA has accepted RedHill's manufacturing plan towards filing the CMC package as part of a potential U.S. New Drug Application (NDA) to be submitted for RHB-105, subject to successful completion of the planned confirmatory Phase III study.
Following a previous positive FDA meeting announced in April 2016, and in light of guidance received on the potential path for marketing approval of RHB-105, advanced preparations continue for the confirmatory Phase III study with RHB-105 for the treatment of H. pylori infection. The two-arm, randomized, double-blind, active comparator confirmatory Phase III study, comparing RHB-105 against a high-dose amoxicillin and omeprazole regimen, is planned to be initiated in the first half of 2017, after completion of the ongoing supportive pharmacokinetic (PK) program. The confirmatory Phase III study is planned to enroll approximately 440 patients in up to 55 clinical sites in the U.S.
The planned confirmatory Phase III study, along with the results from the successfully completed first Phase III study with RHB-105 (the ERADICATE Hp study) and data to be obtained from the ongoing supportive PK program, are expected to support an NDA for RHB-105.
The ERADICATE Hp Phase III study with RHB-105 successfully met its primary endpoint of superiority over historical standard-of-care (SoC) eradication rate of 70%, with high statistical significance (p<0.001). The ERADICATE Hp study results demonstrated 89.4% efficacy in eradicating H. pylori infection with RHB-105. Notably, subsequent open-label treatment with SoC therapies of patients in the placebo arm of the ERADICATE Hp study demonstrated only 63% eradication rate, further supporting the potential superior efficacy of RHB-105 over SoC.
RHB-105 was granted Qualifying Infectious Disease Product (QIDP) designation by the FDA, providing a Fast-Track development pathway, as well as NDA Priority Review status, potentially leading to a shorter NDA review time by the FDA, if filed. If approved, RHB-105 will also receive an additional five years of U.S. market exclusivity, in addition to the standard exclusivity period, for a total of 8 years of U.S. market exclusivity.
RedHill is pursuing with RHB-105 an indication of first-line treatment of H. pylori infection, regardless of ulcer status, a significantly broader indication than current standard treatments for H. pylori, which are typically indicated only for patients with active or recent history of duodenal ulcer disease. If approved, RHB-105 may be the first H. pylori eradication therapy to target this broader indication, which would significantly expand the potential patient population for this drug candidate.
H. pylori bacterial infection is a major cause of chronic gastritis, peptic ulcer disease, gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma. H. pylori infection is estimated to affect over half of the adult population worldwide. The growing resistance of the H. pylori bacteria to metronidazole and clarithromycin has resulted in increasing failure rates of current SoC for H. pylori eradication, reaching an estimated 30%1. Despite the strong unmet medical need, no new drug has been approved by the FDA for this indication in over a decade.
The 2015 global and U.S. market potential for H. pylori eradication therapies at current branded prices, were estimated at approximately $4.83 billion and $1.45 billion, respectively, and could potentially grow with increasing awareness of the health risks associated with H. pylori infection and the benefits of its eradication2.
About RHB-105:
RHB-105 is a new and proprietary fixed-dose oral combination therapy of two antibiotics and a proton pump inhibitor (PPI) in an all-in-one oral capsule with a planned indication for the treatment of H. pylori infection. H. pylori bacterial infection is a major cause of chronic gastritis, peptic ulcer disease, gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma. A first Phase III study with RHB-105 was completed in the U.S. with positive results (the ERADICATE Hp study). The study demonstrated an overall success rate of 89.4% in eradicating H. pylori, and met its protocol-defined primary endpoint of superiority in eradication of H. pylori infection over historical standard-of-care efficacy levels of 70%, with high statistical significance (p<0.001). A confirmatory Phase III study is planned to be initiated in the U.S. Additional studies may be required, subject to FDA feedback. RHB-105 has been granted Qualifying Infectious Disease Product (QIDP) designation by the FDA, providing a Fast-Track development pathway, as well as NDA Priority Review status, potentially leading to a shorter NDA review time by the FDA, if filed. If approved, RHB-105 will also receive an additional five years of exclusivity, in addition to the standard exclusivity period, for a total of 8 years of U.S. market exclusivity.
About RedHill Biopharma Ltd.:
RedHill Biopharma Ltd. (NASDAQ:RDHL) (TASE:RDHL) is a biopharmaceutical company headquartered in Israel, primarily focused on the development and commercialization of late clinical-stage, proprietary, orally-administered, small molecule drugs for the treatment of gastrointestinal and inflammatory diseases and cancer. RedHill's pipeline of proprietary products includes: (i) RHB-105 - an oral combination therapy for the treatment of Helicobacter pylori infection with successful results from a first Phase III study; (ii) RHB-104 - an oral combination therapy for the treatment of Crohn's disease with an ongoing first Phase III study and an ongoing proof-of-concept Phase IIa study for multiple sclerosis; (iii) BEKINDA® (RHB-102) - a once-daily oral pill formulation of ondansetron with an ongoing Phase III study for acute gastroenteritis and gastritis and an ongoing Phase II study for IBS-D; (iv) RHB-106 - an encapsulated bowel preparation licensed to Salix Pharmaceuticals, Ltd.; (v) YELIVA™ (ABC294640) - a Phase II-stage, orally-administered, first-in-class SK2 selective inhibitor targeting multiple oncology, inflammatory and gastrointestinal indications; (vi) MESUPRON – a Phase II-stage first-in-class, orally-administered uPA inhibitor, targeting gastrointestinal and other solid tumors and (vii) RIZAPORT® (RHB-103) - an oral thin film formulation of rizatriptan for acute migraines, with a U.S. NDA currently under discussion with the FDA and marketing authorization received in Germany in October 2015.
This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements may be preceded by the words "intends," "may," "will," "plans," "expects," "anticipates," "projects," "predicts," "estimates," "aims," "believes," "hopes," "potential" or similar words. Forward-looking statements are based on certain assumptions and are subject to various known and unknown risks and uncertainties, many of which are beyond the Company's control, and cannot be predicted or quantified and consequently, actual results may differ materially from those expressed or implied by such forward-looking statements. Such risks and uncertainties include, without limitation, risks and uncertainties associated with (i) the initiation, timing, progress and results of the Company's research, manufacturing, preclinical studies, clinical trials, and other therapeutic candidate development efforts; (ii) the Company's ability to advance its therapeutic candidates into clinical trials or to successfully complete its preclinical studies or clinical trials; (iii) the extent and number of additional studies that the Company may be required to conduct and the Company's receipt of regulatory approvals for its therapeutic candidates, and the timing of other regulatory filings, approvals and feedback; (iv) the manufacturing, clinical development, commercialization, and market acceptance of the Company's therapeutic candidates; (v) the Company's ability to establish and maintain corporate collaborations; (vi) the Company's ability to acquire products approved for marketing in the U.S. that achieve commercial success and build its own marketing and commercialization capabilities; (vii) the interpretation of the properties and characteristics of the Company's therapeutic candidates and of the results obtained with its therapeutic candidates in research, preclinical studies or clinical trials; (viii) the implementation of the Company's business model, strategic plans for its business and therapeutic candidates; (ix) the scope of protection the Company is able to establish and maintain for intellectual property rights covering its therapeutic candidates and its ability to operate its business without infringing the intellectual property rights of others; (x) parties from whom the Company licenses its intellectual property defaulting in their obligations to the Company; (xi) estimates of the Company's expenses, future revenues capital requirements and the Company's needs for additional financing; (xii) competitive companies and technologies within the Company's industry; and (xiii) the impact of the political and security situation in Israel on the Company's business. More detailed information about the Company and the risk factors that may affect the realization of forward-looking statements is set forth in the Company's filings with the Securities and Exchange Commission (SEC), including the Company's Annual Report on Form 20-F filed with the SEC on February 25, 2016. All forward-looking statements included in this Press Release are made only as of the date of this Press Release. We assume no obligation to update any written or oral forward-looking statement unless required by law.
1 Malfertheiner P. et al. Management of Helicobacter pylori infection – the Maastricht IV/ Florence Consensus Report, Gut 2012;61:646-664.
2 Jerry Rosenblatt, Ph.D., a member of RedHill's Advisory Board and Partner at Foster Rosenblatt, RedHill Biopharma press release: RedHill Biopharma's Investor Webcast Forum Provides Update on the RHB-105 Phase III Program and Potential H. Pylori Eradication Market, May 18, 2015.
Company contact:
Adi Frish
Senior VP Business Development &
RedHill Biopharma
IR contact (U.S.):
Marcy Nanus
Senior Vice President
The Trout Group
Source: RedHill Biopharma Ltd. via GLOBE NEWSWIRE


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A PAIR of former Oxford United players were on target as a fired-up Newport County brought an end to the last remaining unbeaten away record in English league football.
Ryan Burge and Chris Zebroski struck in the final 20 minutes to inflict United's first defeat on their travels in Sky Bet League Two since April 1 - a remarkable 16 games.
On the balance of play Newport were worthy winners, but they had to come from behind after James Constable's superb early finish.
United absorbed plenty of pressure, but Newport found an equaliser in first-half stoppage time through Rene Howe.
A sublime free-kick from Burge and an awful defensive mix-up from which Zebroski profited put County on top, before Alfie Potter's late goal gave them cause for concern.
The United team sheet showed one change from the side which started Saturday's 3-0 win over Mansfield.
Josh Ruffels came into replace David Connolly as Mickey Lewis reverted back to a 4-4-2.
Pitch problems at Rodney Parade had postponed six of Newport's previous seven games and they began like a side in a hurry to make up for lost time.
Backed by a vociferous crowd they dominated the first half, with United only able to launch occasional forays forward.
Zebroski, one of three ex-United players in the County side, had the first chance after a smart lay-off from Howe. Ryan Clarke was alert to the danger, though, and ran out to smother the shot.
United had barely strung two passes together when they took a surprise lead on 14 minutes.
Dave Kitson found some space and crossed for Constable, who expertly controlled the ball and swivelled to bury a left-footed shot past goalkeeper Elliott Parish.
It was a stunning counter punch after being on the back foot, but County carried on regardless.
Clarke quickly had to tip over a header from Ismail Yakubu at a corner.
Despite the lead, United still had no real foothold in the game. James Constable was often their only real outlet and if the ball forward to him was not right, County were able to start another attack.
The playing surface was a concern in patches and ground staff even worked on it when play was stopped while Deane Smalley received treatment.
The visitors dealt with the pressure well, until first-half stoppage time.
Andy Sandell got forward and his cross from the left was only cleared to the edge of the box, where Minshull's shot was deflected by Howe past a wrong-footed Clarke.
Lewis's response at the break was to bring on Potter for Danny Rose and switching to a 4-2-3-1 system.
It did little to alter the flow of the game and Adam Chapman, another U's old boy, came within inches of a fine volleyed goal from 20 yards on 54 minutes.
Chapman was involved again on the hour, going in hard on Tom Newey, who reacted angrily. Both were booked, but it was more costly for the United defender - his tenth of the season, it means a two-game suspension.
Still Newport pressed and with 20 minutes remaining Burge put them ahead. Ruffles fouled Howe on the right corner of the area and Burge curled a shot into the far corner.
Lewis brought on Connolly for Matt Bevans with his final roll of the dice, reverting to a back three in the process.
Their hopes were dealt a calamitous blow on 82 minutes, when a breakdown in communication saw Johnny Mullins play a back pass past Clarke and gifted Zebroski the easiest of tap-ins.
The game looked over, but with three minutes of normal time remaining Potter poached a goal from close range.
It set up a frantic finish but United could not conjure a clear opening as their long away run was finally halted.
Oxford Utd (4-4-2): Clarke, Bevans, Hunt, Mullins, Newey, Smalley, Wroe, Rose, Ruffels, Kitson, Constable.
Subs used: Potter (Wroe ht), Williams (Kitson 58), Connolly (Bevans 75).
Unused subs: Henly, Long, Davies, Ashby.
Booked: Newey.
Newport (5-3-2): Parish, Pipe, Anthony, Yakubu, Sandell, Willmott, Minshull, Chapman (Porter 85), Burge, Zebroski (Jeffers 85), Howe.
Unused subs: Thompson, Crow, Jackson, Naylor, Jolley.
Booked: Chapman.
Referee: Oliver Langford (West Midlands).
Attendance: 3,757 (523 visitors).
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There was a large local turnout for the Nov. 6 election with Jamaica Plain residents facing long lines at some polling stations. President Barack Obama won reelection, challenger Elizabeth Warren topped incumbent U.S. Senator Scott Brown, and the state approved medical marijuana.
JP residents also saw the beginnings of the 2013 mayoral race. Will Dorcena, a former At-Large City Council candidate, had campaign signs for mayor up near some polling stations.
The race for the U.S. Senate seat was a competitive one with JP bearing witness to that. Both Democrat Warren and Republican Brown set up campaign offices in Hyde Square and both made numerous campaign stops in JP rallying supporters. It was the first time in local political memory that Republicans had a local campaign office.
Warren visited her one-week-old campaign office at 405 Centre St. on Election Day, where City Councilors Felix Arroyo and Tito Jackson also were helping her. In the end, Warren garnered the victory, winning 74 percent of the Boston vote and probably better than that in JP.
There were two other contested local federal races. Incumbent Stephen Lynch (Democrat) beat challenger Joe Selvaggi (Republican) for the U.S. Congressional 8th District seat.
Democrat U.S. Rep. Mike Capuano (7th District) won reelection over Independent Karla Romero.
On the state level, Democratic Reps. Jeffrey Sánchez (15th Suffolk District), Liz Malia (11th Suffolk District) and Russell Holmes (6th Suffolk District) and Democratic Sen. Sonia Chang-Díaz (2nd Suffolk District) all won reelection and did not face an opponent.
For the Governor's Council, which confirms judicial appointments, among other duties, Democrat Robert Jubinville beat Republican Earl Sholley for the District 2 seat. Democrat Christopher Iannella, a JP resident, won the District 4 seat running unopposed.
JP residents also had the opportunity to help decide several ballot questions. Some JP residents did not receive the state booklet detailing each ballot question.
A woman, who wished not to be named, called the Gazette to say that many residents at the 147-unit Forbes Building at 545 Centre St. did not receive the booklet. The booklet was also not received on at least part of St. Rose Street and part of Centre Street in Canary Square. But the Gazette did receive one at its post office box.
Question 1 concerned automobile manufacturers being required to provide diagnostics to consumers and repair shops. Legislation recently was passed and then signed by Gov. Deval Patrick that requires automobile manufacturers to do just that. But the question remained on the ballot and it was approved.
Question 2 would have allowed terminally ill patients who have been given six months or less to live the ability to obtain lethal drugs to commit suicide. The measure appeared to fail in a close vote that was still being counted at the Gazette's deadline.
Question 3, which concerned the legalization of medical marijuana, was approved.
Two other, non-binding questions that appeared on local ballots were approved by large margins. One, organized by JP's Mass. Alliance of HUD Tenants and other groups, asks elected officials to call for cuts in military spending to sustain social programs. The other asks elected officials to call for restrictions on the free speech rights of corporations and nonprofits enabled by the U.S. Supreme Court's Citizens United ruling.


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Conference Info Menu
LAMPSIG is a special interest group focusing both on backend web development and end user web interfaces. The LAMP environment (Linux Apache MySQL PHP) is the SIG's starting point.
As far as the group is concerned, the open source nature of the platform is its greatest strength. So any alternative open source components will work just as well (e.g. FreeBSD AOLServer PostgreSQL Perl).
The concept of an open source web development and web hosting platform matters much more than the acronym chosen to represent it.
Visit website for more information: http://www.lampsig.org/


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October 22, 2012
Support Sexual Health Awareness Peer Educators by dining at Local Food and Friends restaurant
Sexual Health Awareness Peer Educators, or SHAPE invites you to take a friend and dine at Local Food and Friends, 3011 Anderson Ave., today for lunch or dinner. The proceeds will go toward educating students on the importance of being aware and taking care of their bodies.
The group of peer educators put on presentations and for their fellow students throughout the year, focusing on healthy lifestyle behaviors and prevention of STDs. The group relies on fundraisers to make these educational programs possible. Join us today at Local to help a good cause.


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Ryan Meyer is a PhD student at ASU's School of Life Sciences where he is writing a dissertation about US federal climate science research and its relationship to policy making. He is spending a yer in Australia on a Fulbright and he blogs at Adapt Already.
If four out of five global climate models (GCMs) agree on a result, should we feel more confident about that result? Does agreement among models constitute increased certainty about the models' basis in reality? My colleagues and I wondered about this a few years ago when we started noticing that many climate scientists seem to adopt this logic without any explanation or justification. They claim, for example, that we should be more worried about drought in the southwestern US because 18 out of 19 models predict a transition to a more arid climate over the next 50 years. Or they pick a subset of models to represent a particular process such as the Asian monsoon, and then point to agreement among those models as significant.
If 18 models get the same result, is that better than just one? Why? Climate science should provide a thorough explanation for this, especially if climate models are to begin informing policy decisions.
We argue in a paper now available in Environmental Science and Policy (PDF here) that agreement is only significant if the models are sufficiently independent from one another. The climate science community has mostly ignored the crucial problem of model independence while taking advantage of a tacit belief in the force of model agreement. To quote from our introduction:
GCMs are commonly treated as independent from one another, when in fact there are many reasons to believe otherwise. The assumption of independence leads to increased confidence in the ''robustness'' of model results when multiple models agree. But GCM independence has not been evaluated by model builders and others in the climate science community. Until now the climate science literature has given only passing attention to this problem, and the field has not developed systematic approaches for assessing model independence.To some these arguments may seem like nitpicking. Or they might seem better suited to the pages of some technical journal where modelers work these things out for themselves. But we strongly believe that this extends beyond methodology, and is in fact a policy question. It relates to the kind of investments we can and should be making in climate science.
The question of independence is one small piece of a much needed broad discussion about climate science policy. What kinds of knowledge are most helpful in crafting a response to climate change? What institutions, disciplines, and tools are best suited to deliver such knowledge? Such crucial questions of science policy tend to be ignored. We argue about what "the science" says, rather than how it works and how it could work better for the needs of decision makers.
In our paper, we take it as a given that governments will continue to fund large and complex models of the climate and related systems. (A broader discussion about the merits of this investment is important, but we do not directly address it). But how should they be funded? Who should decide the most important questions to pursue? In the past, we have tended to let climate scientists sort that one out. They are, after all, the experts. But they are certainly not unbiased participants in this discussion. Are they asking the most important questions, or just the ones they find most interesting?
It is important to recognize that there are many possible trajectories for our climate science knowledge. We may not know exactly where each one leads, but we can still make wise, informed choices. This is why the independence problem is important, not just for climate modelers, but for science policy makers, potential users of climate science, and advocates for climate change adaptation.
We have three basic recommendations related to the independence problem:
- Climate modelers should be wary of overselling results based on model agreement.
- The climate science community should begin to better address the independence problem.
- Science policy decision makers should take this problem into account when building strategies for climate modeling, and climate science more broadly.


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THAVENET, JEAN-BAPTISTE, Sulpician; b. 2 Sept. 1763 in Bourges, France; d. 16 Dec. 1844 in Rome.
Jean-Baptiste Thavenet entered the Séminaire de Bourges in 1782 and was ordained priest in 1789. In May 1785 he had been admitted into the Society of Saint-Sulpice to do his solitude (noviciate) in Paris. In the course of the French revolution the Sulpicians, like many members of religious communities, experienced difficulties since they refused to take the oath of loyalty to the Civil Constitution of the Clergy. Non-juring priests had to go underground or into exile: Thavenet sought refuge in London. Facing an influx of French priests, the British government agreed to give a number of them permission to go to Lower Canada, temporarily changing the policy it had maintained since the conquest. On 4 June 1794 Thavenet, along with ten other Sulpicians, sailed from Portsmouth [see Jean-Henry-Auguste Roux*].
After an uneventful crossing the group reached Montreal on 12 September. The advent of these new members proved a stimulus to the community at the Séminaire de Saint-Sulpice, but it also created tensions that left their mark on Thavenet. The seminary was becoming Canadianized, since local candidates had been accepted to fill the vacancies and they were now in the majority. Some of them looked unfavourably upon the arrival in force of the Frenchmen. The French Sulpicians distrusted the Canadians and wanted to retain control of the seminary and to preserve links with the mother house in Paris. Such was the climate in which Thavenet started to work in Montreal.
By October 1794 Thavenet was teaching at the Collège Saint-Raphaël (which would become the Petit Séminaire de Montréal in 1806), but he did not get on well with its director, Jean-Baptiste Marchand*. In 1797 Bishop Pierre Denaut* of Quebec named him curate to assist François Cherrier* in the parish of Saint-Denis on the Richelieu. That same year he was assistant priest at Notre-Dame in Montreal. Then in 1800 he was sent as a missionary to Lac-des-Deux-Montagnes (Oka). There he learned enough Algonkin to translate works into that language and to prepare an Algonkin-French dictionary, which would remain in manuscript form. He began teaching again at the Petit Séminaire de Montréal in 1809 and in October 1815 he left for Paris.
Thavenet then embarked on a career in Europe as financial agent for several religious communities and lobbyist for the Séminaire de Saint-Sulpice of Montreal. His mission went through two phases: from 1815 to 1831 he worked in France and England, where he was preoccupied with matters related to the recovery of debts; from 1831 to 1844 he lived in Rome and kept the views of the Montreal Séminaire de Saint-Sulpice before the Curia. He took a vigorous part in the various episodes of the dispute between the bishops of Lower Canada and the Montreal Sulpicians, which regularly ended up in Rome [see Joseph-Vincent Quiblier*].
The religious communities in Lower Canada had some capital invested in France, particularly in annuities. During the revolution and the Napoleonic Wars not only did interest payments cease, but ownership of the annuities was called into question. After the Restoration the communities tried to recover their investments. Thavenet acted specifically for the Séminaire de Québec, the Ursulines, the Hôtel-Dieu of Montreal, the Congregation of Notre-Dame, and the Hôpital Général of Montreal. Obtaining payment of financial claims took prolonged efforts but was finally accomplished. It is calculated that the three women's communities of Montreal received 1,800,000 francs. According to historian Robert Lahaise, the infusion of capital signalled a new prosperity that resulted in a sudden upsurge of building by the Montreal communities and enabled them to modernize and enlarge their facilities. Thavenet's success even prompted some families to make use of his services. In 1826, for example, Barthélemy Joliette and his brothers-in-law asked him to recover the estate left by a distant relative whose property had been sold as property of the nation.
Despite the positive results of his work and the devotion he had shown, Thavenet saw his administrative competence questioned. It was generally agreed that his bookkeeping was inadequate; Wilfrid-H. Paradis, who examined his files in Paris, considers them insufficently clear and precise. In addition Thavenet reputedly suffered from the bankruptcy of some of his agents and probably from their misappropriation of funds. In 1833–34 Abbé Thomas Maguire* spent several months with him trying unsuccessfully to make sense of his accounts; Maguire none the less thought that 150,000–160,000 francs had been lost through bankruptcies. When ordered by Archbishop Joseph Signay of Quebec to render his accounts, Thavenet equivocated; he appeared unconvincing to the representatives whom Signay sent on several occasions, published a reply in 1836 to the objections of the committee examining his accounts, and seemed to believe that he was the victim of injustice and persecution because of his work with the authorities in Rome on behalf of the Séminaire de Saint-Sulpice in Montreal. Finally, in 1840 the archbishop withdrew his powers as agent, but his papers were not seized by the authorities in Rome until a few months before his death.
Thavenet had been instrumental in defending the seminary's interests. He quickly became its principal lobbyist and, being well placed in Rome, he proved a formidable adversary of its foes. During the first half of the 19th century the Sulpicians were confronted with two major problems. The first, which dated from the conquest, concerned the title to the seigneury of Île-de-Montreal: the Séminaire de Saint-Sulpice in Paris, which had been given the property, had made it over to the Montreal seminary in 1764, but the transfer had not been formally recognized by the government. This precarious situation rendered the Sulpicians cautious in managing their assets and encouraged them to remain loyal to the colonial authorities. Not until 1841 were their rights finally recognized. The second and much more complicated problem concerned the relations between the seminary and the ecclesiastical hierarchy of Lower Canada. The growth of the city and region of Montreal would lead to the creation of a new diocese in 1836 and a restructuring of authority within the church. Accustomed to being pre-eminent on the island and in the city, the Sulpicians were the losers from the start and did not look favourably on developments, particularly because they feared that a new bishop would covet their assets. This rivalry soon became linked with obvious friction between French and Canadians.
Thavenet was involved in all these problems. In 1819 he turned his attention to the rights of the Séminaire de Saint-Sulpice along with his colleague Jean-Jacques Lartigue, who had been sent to London. From 1821 relations between the seminary and the hierarchy deteriorated rapidly. Lartigue's elevation to the episcopacy, Bernard-Claude Panet*'s rejection of the proposed settlement of 1827 by which Saint-Sulpice would have exchanged its property for a government annuity [see Jean-Henry-Auguste Roux], the question of the episcopal authority to name the curé of Notre-Dame parish in Montreal, the archbishop of Quebec's refusal to allow the seminary to recruit priests in France, and the creation of a diocese in Montreal – all made it necessary for the Sulpicians to put their case in Rome. The indefatigable Thavenet served as spokesman for them there. He played a central role in the disputes, and in the opinion of those who have looked into the matter, he personally added fuel to the fire and kept dissension going through the stands he took, his voluminous correspondence, his reports (some anonymous), and his prejudices about Canadians. The fact that rivalry between the seminary and the bishop of Montreal continued long after his death, however, indicates that what was at issue went well beyond simple personality clashes: the institutional framework to be established for the Catholic population was at stake.
One last aspect of Thavenet's work must be stressed. He acted as agent of the Sulpicians and the religious communities in Montreal for the purchase of books, devotional objects, and accoutrements for use in religious rites.
Jean-Baptiste Thavenet's career illustrates well the relations that the Catholics in Lower Canada maintained with the outside world, in particular with the three key centres of London, Paris, and Rome. It also shows that in this area an individual might come to play a strategic role. Thavenet lived in Lower Canada only from 1794 to 1815 but he held an important place in its religious life.
[The significance of Jean-Baptiste Thavenet's career is reflected in massive files at the ASSM (section 21, nos.17–18) and the Arch. du séminaire de Saint-Sulpice in Paris. The ACAM and the archives of almost all of the other religious communities which he served as agent also have correspondence files for him. W. H. Paradis, "Le nationalisme canadien dans le domaine religieux; l'affaire de l'abbé Thavenet," RHAF, 7 (1953–54): 465–82; 8 (1954–55): 3–24, provides a useful guide to the sources in Paris. Louis Rousseau, La prédication à Montréal de 1800 à 1830: approche religiologique (Montréal, 1976), describes the Séminaire de Saint-Sulpice at the beginning of the 19th century, and B. J. Young, In its corporate capacity; the Seminary of Montreal as a business institution, 1816–1876 (Kingston, Ont., and Montreal, 1986), outlines its economic activities. The tensions that existed between Lartigue and the Sulpicians are examined in Chaussé, Jean-Jacques Lartigue. j.-c.r.]
J.-B. Thavenet is the author of Résumé de la discussion des erreurs qui a cru voir dans mes comptes le comité qui a été chargé de les examiner (Rome, 1836).
ANQ-M, CN1-295, 15 sept. 1826; CN5-25, 10 avril 1826. ASQ, Fonds Viger-Verreau, sér.O, 0141: 134. BVM-G, Coll. Gagnon, corr., J.-B. Thavenet à Morland and Co., 28 févr. 1831. Allaire, Dictionnaire. Dionne, Les ecclésiastiques et les royalistes français. [J.-]H. Gauthier, Sulpitiana ([2e éd.], Montréal, 1926). Robert Lahaise, Les edifices conventuels du Vieux Montréal: aspects ethnohistoriques (Montréal, 1980). Pouliot, Mgr Bourget et son temps, vol.1. Rumilly, Hist. de Montréal, vol.2.
© 1988–2024 University of Toronto/Université Laval
Cite This Article
Jean-Claude Robert, "THAVENET, JEAN-BAPTISTE," in Dictionary of Canadian Biography, vol. 7, University of Toronto/Université Laval, 2003–, accessed February 29, 2024, http://www.biographi.ca/en/bio/thavenet_jean_baptiste_7E.html.
The citation above shows the format for footnotes and endnotes according to the Chicago manual of style (16th edition). Information to be used in other citation formats:
Permalink: | http://www.biographi.ca/en/bio/thavenet_jean_baptiste_7E.html |
Author of Article: | Jean-Claude Robert |
Title of Article: | THAVENET, JEAN-BAPTISTE |
Publication Name: | Dictionary of Canadian Biography, vol. 7 |
Publisher: | University of Toronto/Université Laval |
Year of publication: | 1988 |
Year of revision: | 1988 |
Access Date: | February 29, 2024 |


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Recently, amid tractors and cranes, on the edge of a deep trench being dug just north of the Resnick Pavilion, we spoke with John Bowsher, who is overseeing the installation of Michael Heizer's Levitated Mass.
The sculpture will be complete this fall, after a 340-ton boulder is maneuvered into place above an open slot more than 450 feet long. Visitors will be able to pass beneath the boulder and experience it hovering above them.
In the video below, John talks about the physical dynamics of the construction and the process of working with a living artist on a truly massive project.
Amy Heibel, with Alexa Oona Schulz


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Angelina Jolie is getting behind Malala Yousafzai's aspirations for an education.
In tribute to the 14-year-old Pakistani activist who was shot by the Taliban last week, the Hollywood star's Education Partnership for Children of Conflict is donating $50,000 to Daily Beast founder Tina Brown's Women in the World Foundation, which aims to provide funds to women and girls' "fighting for girls' education in Pakistan and Afghanistan."
"As a response to Malala's bravery, girls across Pakistan, Afghanistan and the world are standing up and saying, 'I am Malala'--and this is our opportunity to show the same solidarity," wrote Jolie and Brown in a joint statement on Women in the World's website.
Angelina Jolie: My kids want a statue built for Malala Yousafzai
Part of the Beyond Borders star's charitable donation will go toward creating a Women of Impact Award for Girls' Education in honor of Yousafzai's struggle.
Just yesterday, Jolie--who has long served as a United Nations Goodwill Ambassador and special envoy of the U.N. High Commissioner for Refugees--penned a letter published in the Daily Beast titled "We Are All Malala," in which she encouraged people to support education as a basic human right.
The actress also wrote how she discussed with her and Brad Pitt's children the attempt on Yousafzai's life, and how their "8-year-old suggested that the world build a statue for Malala."
U.S. & World
News from around the country and around the globe
Madonna honors Malala Yousafzai by stripping in concert, scrawls name on her back
We'd say the donation is a good start.
Doctors in Pakistan have managed to stabilize Yousafzai after the violent attack last week in which she was shot in the head. She has since been airlifted to Great Britain, where she's undergoing special long-term care to repair her damaged skull and is expected to survive.


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Sri Lanka's 26-year civil war between the government and the separatist Liberation Tigers of Tamil Eelam (LTTE) came to a dramatic end in May with a decisive military victory and the killing of Velupillai Prabhakaran, the Tigers' fearsome leader. President Mahinda Rajapaksa is the man who tamed the Tigers. Now his task is to heal a nation still divided by tensions between the majority Sinhalese and the minority Tamils. In a rare, wide-ranging interview, Rajapaksa, 63, talked with TIME's Jyoti Thottam at the President's official compound in Colombo on July 10.
TIME: Prabhakaran had become practically a mythical figure in Sri Lanka. What went through your mind when you heard he had been killed?
Rajapaksa: Thank the Lord. Thank the [Buddhist] Triple Gem. That was a gift.
How did he die?
We know that he was shot that's all. I was not interested in finding out how he was shot, but whoever that was deserved some credit. The most important thing is that he's no more. I would have preferred to bring him here and have a chat with him. I have never seen this man.
What would you have asked him?
Why he did all these mad things. [Laughs.] What else can I ask him?
You came under fairly intense pressure from the U.S. and European governments to call a cease-fire during the final offensives against the Tigers. You resisted that pressure, and yet these are some of your biggest trading partners. Are you worried about jeopardizing those relationships?
I don't think they're so petty-minded. They're the people who encouraged us to defeat terrorism. We followed what [George W.] Bush said. We accomplished what he wanted: eliminate terrorism. They must give credit to us. We fought their war. We showed that you can defeat terrorism.
Some foreign policy analysts saw the last stage of the war as a test case for the idea that the international community has the responsibility to protect civilians caught in a cross fire.
It's my citizens. I am responsible for them. I have to protect them and get them out. If I allow some foreign country to come and do that, they would have killed most of the people. It is my soldiers who will protect my citizens. They are my people, they are my voters ... The international community must help the government if a government is elected properly by the people.
What if an elected government is acting against its own people?
Are you going to punish [all the] citizens for that or the man who is responsible? Take me. Say that I violated all these human rights, killed people, right? Do you punish me, Mahinda Rajapaksa, or the innocent people of this country by sanctions, embargoes, travel advisories? There are ways of punishing me if you want. There, now by saying that, I will get punished. [Laughs.]
Many people feel that the way you ended the war sets a dangerous precedent that the cost in terms of human rights, in terms of civilian casualties, was too high.
I reject that totally. There was no violation of human rights. There were no civilian casualties. If I did that, it wouldn't have taken 2½ years to finish this. I would have done this in a few hours. These are all propaganda.
The U.N. stands by its number: 7,000 civilian casualties.
Seven thousand? No way. In the eastern province, zero casualties. I won't say there are zero casualties in the north. The LTTE shot some of them when they tried to escape.
There is so much that is not known. Would you be willing to have a Truth and Reconciliation Commission?
We must find out what has happened. The thing is, if you start something, I don't want to dig into the past.
Many people feel that's exactly what Sri Lanka needs, to talk about what happened in the past.
There must be a way, that it must not be felt that they will be punished again. Then you will have the north and the south fighting each other again; you can't have that again. I don't want to dig into the past and open up this wound.
Sometimes a wound needs airing to heal.
That is where the West is different from the East.
What is your priority now?
Over 300,000 people are in the IDP [internally-displaced persons] camps. The whole area is mined. We must de-mine the whole area, give basic facilities, water, electricity, roads, resettle them.
What is your time frame?
We have a 180-day program. That is our plan. In 180 days, we want to settle most of these people.
What would you like to accomplish before the next presidential election [which could be held as early as November]?
At least 50% must be released. I would say 60%.
Is that a promise?
It's not a promise, it's a target.
There is a sense of relief in the country now that the war is over, but there is also some anxiety among Tamils over what happens next.
If you ask the IDPs, they'll say, We want to go back to our villages. If you ask politicians, they'll say, We want this and that. But yes, we need to give a political solution.
Do you believe in some kind of self-governance for the Tamils?
Don't say Tamils. In this country, you can't give separate areas on an ethnic basis, you can't have this. With the provinces, certainly there must be powers, where local matters can be handled by them.
What if the people in the north want a model of governance that's somewhat different from the rest of the country?
That I will not allow. The whole country must have a system. You can't have one system for the north and one for the east.
There are already signs of development new roads, new bridges but I've also heard some concern that the roads, for example, instead of connecting Tamil-majority areas to one another, are connecting the Tamil-majority east to the [Sinhala-majority] south, making it easier for people from the south to do businesss there, to move there. Is there some kind of effort to change the demography of the Tamil-majority areas?
No, but it's happening in Colombo. The eastern-province Muslims have come here. The Tamils have come here. You ask them, Why are you coming here? Can I stop them? No. If anybody wants to come and live in any part of this island, it is the right of a man.
The port project at Hambantota that's a massive new Chinese project.
It's a Sri Lankan project. China helped us. It's a commercial loan. Hambantota is my area, and it had been neglected for so many years. It's my duty, my obligation to develop that area. We must develop not only Colombo, but other districts too.
What do you think China's strategic interest is in this port?
I asked for it. China didn't propose it. It was not a Chinese proposal. The proposal was from us; they gave money. If India said, Yes, we'll give you a port, I will gladly accept. If America says, We will give a fully equipped airport yes, why not? Unfortunately, they are not offering to us.
Is China becoming more important than India as Sri Lanka's ally?
I don't see that. We are not thinking like that. India is our neighbor, our relation, our friend we have a special relationship. For a small country like us, for development, you need money, you need assistance. In this world, who can afford to give us money? We can go to China. We can go to Russia or Brazil. Very few countries can afford to give. Japan is helping us a lot. Our biggest development partner is Japan. India is helping us.
The last time I came to Sri Lanka was in January for the funeral of assassinated journalist Lasantha Wickrematunge. The posthumous editorial that his newspaper published was a very emotional piece. It addressed you.
He was a good friend of mine. He had informed somebody to inform me [that he was in danger]. But unfortunately, I didn't get that message. I would have told him to go to the nearest police station. No one knows what happened.
He was very sure that it was the government.
He wouldn't have called me if it was a government thing ... I hope we will know the truth. Otherwise, I am getting blackguarded and I am getting the blame.


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Knocked Up
Alison Scott is an up-and-coming entertainment journalist whose 24-year-old life is on the fast track. But it gets seriously derailed when a drunken one-nighter with slacker Ben Stone results in an unwanted pregnancy. Faced with the prospect of going it alone or getting to know the baby's father, Alison decides to give the lovable doof a chance. An overgrown kid who has no desire to settle down, Ben learns that he has a big decision to make with his kid's mom-to-be: will he hit the road or stay in the picture! Courting a woman you've just knocked up, however, proves to be a little difficult when the two try their hands at dating. As they discover more about each other, it becomes painfully obvious that they're not the soul mates they'd hoped they might be. With Alison's harried sister Debbie and hen-pecked brother-in-law Pete the only parenting role models the young lovers have, things get even more confusing. Should they raise the baby together? What makes a happy lifetime partnership after all? A couple of drinks and a wild night later, they've got nine confusing months to figure it out.
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USA Consularization Service for Saudi Arabia
Saudi Arabia Legalization Service
Saudi Arabia does not participate in the Convention of 5 October 1961 Abolishing the Requirement of Legalisation for Foreign Public Documents, therefore, if your document is being sent to Saudi Arabia from the USA it must be consularized or legalized by the Saudi Arabia Embassy or the Saudi Arabia Consulate office located here in the USA.
Types of Documents acceptable for Legalization
Federal Document issued by DHS, EPA, FBI, FDA, USDA or USPTO
- Certificate of Environmental Protection Agency (EPA)
- Certificate of Exportability
- Certificate of Pharmaceutical Products. (CPP)
- Certificate to Foreign Government (CFG)
- Certificate of Origin
- Certified copy of Naturalization from US Department of Homeland Security (DHS)
- Export Certificate for Animal Products
- FBI Background Check
- Free Sale Certificate issued by the US Food and Drug Administration (FDA)
- Phytosanitary or Plant Certificate
- USDA Animal Health Certificate
- USPTO Patent Certificate
- USPTO Trademark Certificate
Personal Documents
- Affidavit - Any Signed & Notarized document
- Birth Certificate or Death Certificate
- Drivers Licenses
- Passport
- Court Record - Criminal Record
- Divorce Certificate
- Educational Documents - Diploma, Transcript
- Local Police Background Check Marriage License
- Medical Letters
- No Record of a Marriage - Single Status Letter
- Permission to Travel document
- Power of Attorney
- Social Security Letter
- Teacher Credentials
Commercial Documents
- Agency Agreement
- Assignment
- Business Letter
- Certificate of Analysis
- Certificate of Free Sale
- Certificate of Origin
- Certificate of Status
- Commercial Invoice
- ISO Certificate
- Articles of Incorporation
- Articles of Organization
- Board Resolution
- Business License
- Certificate of Amendment
- Certificate of existence
- Certificate of Good Standing
- Certificate of Incorporation
- Certificate of Incumbency
- Certificate of Merger
- Certificate of Registration
- Company Bylaws
- FDA Document
- Patent Assignment
- Trademark Assignment
- Distributor Agreement
- Letter of Authorization
- Power of Attorney
- Technical Data Sheet
Embassy Locations
While many consulates are located in New York City because of the United Nations (UN) many of them do not process documents for legalization. If they will not legalized documens in NYC your documents will require embassy legalization in Washington, DC. We offer regular processing of documents & and RUSH expedited service If you want your documents returned in the shortest possible time frame. Each type of document has different handling requirements. Each embassy has its set time to process your document and may require additional time for traveling between locations to get the document legalized.
How long will it take to process my document
Rush Service
The best way to process your document in New York City or Washington, DC is to hire a Courier Service like Notary & Apostille Service. We are located on Long Island, New York but, but offer NY mobile notary public & hand delivery courier service in New York City. In addition, we have affiliates in Washington, DC with a proven track record of safetly delivering your document in a timely manner to the various places your document must go to (e.g., Department of State, Arab Chamber of Commerce) before it can be Consularized by the Embassy for Saudi Arabia.
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If you are in a rush for your documents to be returned to you I strongly recommend you use our Expedited mail service to & from Washington DC & our affiliate service provider in Washington, DC. By using these methods it will save about 5 business days since your documents are hand carried between the Maryland Secretary of State, if necessary, US Department of State, Arab Chamber of Commerce , if necessary, and the Saudi Arabia Embassy.
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A ballet dancer grasps her partner's hand to connect for a pas de deux. Later that night, in the dark, she reaches for her calf to massage a sore spot. Her brain is using different "maps" to plan for each of these movements, according to a new study at UC Santa Barbara.
In preparing for each of these reaching movements, the same part of the dancer's brain is activated, but it uses a different map to specify the action, according to the research. Planning to hold hands is based on her visual map of space. Her second plan, to reach for her calf, depends on the dancer's mental body map.
Two UCSB scientists studied the brains of 18 individuals who made 400 distinct arm reaches as they lay in an MRI scanner. The researchers found clear differences in brain planning activity with regard to the two types of reaching behavior. Their discovery is reported in the journal Neuron.
"Our results have two important applications," said Scott T. Grafton, professor of psychology. "One is robotics. The other is in the area of machine-brain interface; for example, in developing machines to help paraplegics. A critical issue is to understand how movement-related information is represented in the brain if we're to decode it." Grafton, a leading expert in brain imaging, directs the UCSB Brain Imaging Center where the university's MRI scanner is located.
"We're interested in movement planning and movement control," said Grafton. "We're looking at goal-directed behaviors, when we reach to grasp objects -- visually defined objects in our environment. This forms the basis of our interactions with the world."
The current scientific view is that all reaching movements -- those directed to visual targets or toward one's own body -- are planned using a visual map. "Our findings suggest otherwise," said Pierre-Michel Bernier, first author and postdoctoral fellow. "We found that when a target is visual, the posterior parietal cortex is activated, coding the movement using a visual map. However, if a movement is performed in darkness and the target is non-visual, the same brain region will use a fundamentally different map to plan the movement. It will use a body map."
The maps are located in a brain region called the precuneus, inside the parietal lobe. The researchers measured the "Blood Oxygen Level Dependent Signal," or BOLD signal, when looking at the MRI brain images. BOLD is an indirect way of looking at brain activity at a millimeter scale. They also used a methodology called "repetition suppression." This is what makes the study novel, according to the authors, as it is one of the first to identify where these maps are nested in the human brain. "We are a leader in the use of repetition suppression," said Grafton.
Repetition suppression relies on the fact that when a brain region is involved in two similar activities in a row, it is less active the second time around. The team was able to pinpoint the brain's use of body maps versus visual maps by isolating the location in the brain where the responses were less active with repeated, similar arm reaches.
Grafton explained: "The brain is trying to make a map of the world. One map is what you see, which is provided by the visual system. The other map is where the body is in space. This map is based on proprioception -- the sense of limb position -- which is derived from receptors in the skin, muscles, and joints. These maps are very different. How do you connect them? Either the visual map or the body map may be fixed, or neither may be fixed."
The authors' findings argue for the latter, demonstrating that the brain is capable of flexibly switching between these maps depending on the context. No doubt this flexibility underlies our ability to interact with the world with ease despite the ever-changing conditions in which our actions take place.
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Owen Williams interviewed Billy Drago for a UK film magazine, where it was trimmed down to fit the magazine's space constraints. But Williams has posted the full interview at The Void, including a section in which Drago talks about his work on Brian De Palma's The Untouchables, in which he portrayed Frank Nitti. Here is that section:
[The Untouchables] was one of those films where even the things that went wrong went right. It was a difficult shoot in that it was period and we were actually shooting in the city so you have to periodise all those blocks. It was huge. And the studio didn't know it was going to be a hit, and they actually called De Palma and shut it down. They said "okay we've seen the footage, you've got enough, we don't want to spend any more money, that's it, after the weekend you're home", and there were a whole load more scenes we were supposed to shoot.
That's when they went and shot the Odessa Steps sequence in the train station, with a load of raw film stock that De Palma had stored up. That wasn't even in the script. We were supposed to shoot at the race track and a lot of other stuff, and he said 'We can't shoot any of that stuff, so everybody pack up, but in the meantime I'm going to shoot my version of the Battleship Potemkin scene with all this film I've stolen'…
The first scene we shot was where the little kid gets blown up. So I'm outside waiting on the street where they're lighting, and some older woman comes up with a little boy and asks for a picture, so I put my arm around the little boy and all that. And the next day in the newspaper I found that the picture was there! And the little boy was like Nitti's great great grandson.
The guy who was my stand-in was the great grandson of a guy who'd had a Nitti contract out on him! And his grandfather had hidden out in the middle of Illinois until Nitti had died, and survived the hit. But even after that, he got ill and he was in the hospital, and the nurses complained about him because he was sleeping with a pistol under his pillow, because he was convinced he was still gonna get whacked!
I got to know the Nitti family. They still live in the Chicago area and they have grocery stores and businesses: regular businesses; they're not mob connected anymore! They called the hotel where I was staying, which was the actual hotel that had been owned by Capone and Nitti during that period (in fact the very phone booth where Machine Gun Jack McGill was killed was right outside my door). I was down in the lobby and the concierge came over to say that the Nitti family would be by to pick me up at 8 o'clock. Nobody asked if I actually wanted to go… It was an offer I couldn't refuse! But it would have been too interesting an adventure to turn down anyway. So at eight o'clock I'm down in the lobby and a limousine pulls up and a guy gets out and introduces himself as someone who works for the Nitti family, and we drove around every blues club in Chicago, and at every one it was like royalty had arrived. 'The Nitti family is here!' It was great fun but they were making me a little nervous because they gradually started treating me like I really was Frank Nitti. They made sure my back was to the wall so I could see everybody, and all the young Italian turks would come by to pay their respects, and they'd all say "Sooooo, playin' Uncle Frank huh? Lookin' good, lookin' good…" It gave me a bit of an insight into what it would have been like and what had gone on…
They didn't mind Frank being portrayed as such a villain; the legend is so big. They had to move Nitty's grave several times because people kept digging it up to make sure he really was dead; they were so scared of him. Only the family knew where his grave was for a while. I wore a white suit in the movie because we thought of him as the angel of death. I talked to a very elderly gentleman once who'd been a policeman undercover, and he said that Nitti had found him out, and tied him up in a basement and put a gun in his mouth and waited to see if he would sweat. Nitti had a very famous saying: 'I never killed a man who wasn't afraid to die'. So if he'd sweated he would've been killed, but he didn't so Nitti said 'oh okay, he's not afraid' so he let him go.
My mother never quite forgave me for killing Sean Connery. Mom, I had to! They paid me!