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Moyenne Island is a small island of about 9.9 hectares or 24 acres. It is located off the north coast of Mahé, Seychelles, in the Sainte Anne Marine National Park. It has been a flora and animal conservation area since the 1970s. It is the world's smallest National Park. But do you know who owns Moyenne Island?
Brendon Grimshaw purchased Moyenne Island off the coast of Seychelles for £8,000 in 1973 and lived there alone until he died in 2012. He transformed it by planting 16,000 trees and bringing in 2,000 birds and 120 giant tortoises.
Who is Brendon Grimshaw?
Brendon Grimshaw used to work as a news editor for a company in Nairobi, Africa. He decided to sell everything he possessed and tour the world as his contract was about to expire. His explorations took him to India, but he fell in love with the small island.
He and his partner, Rene Lafortune, took on the difficult job of restoring the site to its former splendor after buying the land for 8,000 dollars. In 1996, Grimshaw issued A Grain of Sand, a book about himself and the island. In 2009, A Grain of Sand, a documentary film about Grimshaw and the island, was released.
Brendon Grimshaw never had a spouse and died unmarried. He felt increasingly lonely after his partner died in 2007. Grimshaw died in Victoria, Mahé, in July 2012. (Source: Breaking Travel News)
How Did Grimshaw Obtain the Island?
According to local legend, in the 18th and 19th centuries, the beaches were a haven for pirates. There are cemeteries scattered throughout the island that witnessed its violent past. Phillip Georges bought the island privately in the mid-nineteenth century. While her husband went to work in Maha, his wife wandered the beaches. Grimshaw approached the couple during dinner and made them an offer they couldn't refuse. (Source: Breaking Travel News)
What were Grimshaw's Intentions for the Island?
After 20 years of hard work, Grimshaw and his colleague Lafortune successfully established Moyenne Island as a detached National Park from the Ste. Anne's marine park.
Grimshaw and his partner intended to construct an island of exceptional beauty by planting sixteen thousand trees, building three-mile nature walks, and bringing and breeding Aldabra gigantic tortoises. The island is home to roughly 120 giant tortoises and a diverse plant and birdlife.
Visitors were charged €12 to come ashore, wander the island, dine at the Jolly Roger Restaurant, and relax on the beach. Moyenne Island National Park is currently the name of the island. The island is about 2+12 nautical miles from Mahé's main island.
In 2013, after the island received its own national park status, a new hut was built and a warden was posted on the island, collecting the entrance fee from tourists
After the island was designated as a national park in 2013, a new cottage was built and a warden was stationed on the island to collect the admission fee from visitors. Indeed, he was never in it for the money, declining a 50 million dollar offer to sell the Island who would use it as a party vacation spot. (Source: Breaking Travel News)


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Identification, classification, and prioritization of most influential players in normal biological processes and diseases
Current sequencing technologies have enabled the identification and measuring of the activity of thousands of genes and proteins at a time and across several conditions and cell types. This has a huge benefit for studying the basis as well as the drivers of cancer progression. However, one of the biggest challenges is the selection of right candidates amongst thousands of features for experimental functional validation. Currently, a number of different models have been developed for candidate gene prioritization, most of which rely on external sources of information and, consequently, are not applicable to all data types. Also, most of the available general-purpose models are not optimized for handling and analyzing single-cell data. Moreover, current models are not able to classify genes into "drivers", "biomarkers", and "mediators" according to their functional importance. Here we present, ExIR—Experimental data-based Integrative Ranking— which recruits the potential of Integrated Value of Influence (IVI) algorithm and combines network reconstruction and machine learning techniques to extract, classify and prioritize candidate features from any type of experimental data such as bulk and single-cell RNA sequencing. The evaluation of ExIR in the context of real-world experimental data confirmed its superiority to other respective contemporary methods and algorithms.
Key words
IVI value; influential node; experimental-data-based integrative ranking; ExIR; gene classification; feature prioritization; network analysis; machine learning; systems biology


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Family members of an athlete can be added as "Guardians" to view the team schedule, RSVP to games and events, message team members, and edit the athlete's profile.
If you are interested in becoming a referee, please see link.
USA Hockey information for the parents that are new to the sport of hockey!
Beginners Guide to Ice Hockey


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Alexandria, Va – Action on the 1001 Queen Path, Alexandria, and you can become you've been transmitted straight to Turkey. Colorful artwork adorns the new walls, Turkish audio performs for the music, cases laden up with Turkish snacks, greeted by loving hospitality, and undoubtedly, coffees! This package-of-a-form coffee-and society house, and that exposed inside the , aims so you can connection societies over java. The brand new Turkish Coffees Women Gizem Salcigil White possess discovered her real contacting to make the environment to achieve this.
This new mission of the Turkish Java Girls is to try to render the newest more than 500-year-dated Turkish coffee culture. "The way in which away from enjoying Turkish coffees are a routine, a centuries-dated heritage," says Light. She demonstrates to you you to ingesting Turkish java, it isn't only bring-and-wade. Instead, it is a form of self-worry.
Turks developed the first java making approach throughout the sixteen th 100 years and you may lead the coffee people to Europeans. Turks was in fact the first one to roast and you will work the fresh coffees on the a superb powder and make they for the a unique pot still used today. The richly tasting java is actually wholesome since it is unfiltered. Drinkers found all of the nutrients about coffees.
Light shows you the ancient artwork consists of milling the new beans, roasting him or her, last but not least presenting the coffees. The new routine is actually very first for drinking water to wash their palate to help you liking the newest coffee best, after that reduced sip and revel in the newest take in. Turkish pleasures, some starchy, pleasing chocolate tend to served for the cubes, go with the fresh coffees. Shortly after finishing, there's a customs of understanding the new grinds to share with fortunes.
When speaking with the lady, it's clear she likes their family nation and that's excited about promoting the lady social heritage
Light grew up in Ankara, Turkey's resource city. Their first employment was in banking inside Istanbul, but she easily pointed out that communicating with anybody try more fun than brazilcupid just resting trailing a computer for hours on end. She observed the girl aunt in order to Boston and went to very first Boston School, after that Emerson School. Inside 2008, she transferred to D.C. and, this current year, partnered Nathan Light within George Washington's River Ranch.
They did not just take White much time to realize that people had never ever been aware of Turkish coffee-and its culture. "Someone see Turkey as well as fall in love. It's eden on the planet," states Light, "everywhere you go there can be many thousands of years of history."
Light first started employed in the fresh Turkish Embassy's press workplace in the and was effective in organizing events and you may holding coffee workshops on Turkish society. She quit the woman jobs inside the , fundraised through the people, been a beneficial nonprofit voluntary cluster, and got the woman mission away from home.
The brand new Tourism and Culture Place of work in the Turkish Embassy turned into an excellent sponsor of earliest Turkish java truck journey. Funds was including raised regarding Turkey's oldest coffee crushed vendor Kurukahveci Mehmet Efendi, Turkish Airlines, the new Western Turkish Association off D.C., Turkish cultural communities, and you will personal society people.
Light leased a coffee vehicle and you can, with to ten volunteers (in addition to pupils), proceeded a trip seeing DC, Baltimore, Ny, The latest Refuge, and you can Boston. Regional volunteers throughout the Turkish society in addition to aided after they went along to festivals and you can downtowns, giving away free Turkish coffee. White and her volunteers manage give an explanation for people and you can declare that it lived the life you to Turkish java community symbolizes, creating relationships, serenity, and you will hospitality.
Europeans got breeze of White's You.S. trip and you will expected her to promote Turkish Coffee on Netherlands, Belgium, and you will France for a fortnight. She up coming become helping Turkish Airlines and soon after the nation Bank, but the requirement for their getting a cultural ambassador was strong. For the 2016, she approved Canada's consult and you may toured Toronto.
In the , that have a child in route and to carry out way more balance, White started the first Turkish Coffee Women kiosk inside Tyson's Place Mall. 30 days, she was clinically determined to have cancer of the breast. Having high help from the girl personnel and community participants whom remaining the shop feasible, she went to Poultry to own six months for chemo, rays, and you can operations to treat the lady illness.
Abreast of their return to the new You.S., new pandemic pressed this new Tyson's coffees kiosk to close off down. During this time period, Light first started creating java blends. She as well as authored a foundation to enable women just after seeing how adversely COVID impacted her or him due to the fact number 1 caregivers. The group already been having coffee discussions through Zoom. She says it actually was particularly "Turkish coffee procedures."
During the summer from 2021, Light expected "Istanbul's Microangelo" Hasan Kale to go to eight towns and cities when you look at the Poultry to produce a good documentary reflecting ancient sites and you can realize about their additional coffees plus the rituals as much as her or him. Kale was a musician who creates little ways with the casual objects. The guy have a tendency to uses coffees due to the fact their medium. The new documentary often first to the December cuatro within World Turkish Coffees Date Occasion. (Get a hold of sidebar.)
Congress possess approved Gizem Salcigil Light having connecting the new You.S. and Poultry as a consequence of java. The fresh new Turkish Coffee Women is actually recently chosen since 2022 success story because of the Virginia Business Invention Cardio. She feels you to definitely she's life her fantasy, and her energy is contagiouse visit this specific coffee-and culture family. Given that Light claims, "You don't have to go as high as Poultry. Poultry is within the cardiovascular system out of Old Urban area."
Anybody needless to say come contacting White "The newest Turkish Coffee People," and you may she loves they
The fresh Turkish Coffees Ladies was at 1001 Queen Path from inside the Dated Urban area Alexandria. Circumstances was have always been to 8:00 pm every day.:


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Tom and I spooned on the couch watching television, relaxed, content. I was pregnant with Tommy. "When we have the baby, will we still cuddle like this?"
I don't remember Tom's answer, but I do know that having children made any kind of relaxing difficult for years, much less any cuddling...unless having one to three kids, and sometimes a Siamese cat, squirming between you counts as cuddling. And it's not just children that can come between you, demanding lots of time and attention, but also jobs, pets, housework, or in our case, housebuilding.
But the babies are almost grown now, and we're getting very good at ignoring things that "need to be done," making it possible for us to take off all by ourselves every once in a while like we did yesterday morning, exploring the countryside in the Suzuki Samurai (after stopping at Sonic for drinks.)
The road we drove down yesterday isn't far from us - I've passed it millions of times, wondering where it would take me but never turning to find out. Now instead of wondering, I'll know and remember I was with Tom on our anniversary when I first discovered the beautiful Texas landscape it winds through. It follows a creek, criss-crossing back and forth on low, concrete bridges through ranchland, and in places runs under towering cliffs, some over sixty feet tall. The "creek" is mostly just a limestone bed right now, dotted with a few pools of water where herons have an easy time snacking on captive fish. But clumps of debris caught halfway up nearby oaks warns that at times it is a torrent.
We passed a field of Black-Eyed Susans, budding cactuses, weathered ranchhouses with sheet metal roofs, and gated manors hidden behind stone walls. Ancient oaks somehow still outnumbered junipers.
Real life still interfered for part of the day - shuttling Kendall to band practice, spending a few hours at work, Tom taking care of his chores around the house - but we managed a few minutes snuggling in the hammock, took off by ourselves again in the afternoon and had dinner at the Pier (a local lakeside restaurant), making it home in time to watch the sunset from our back deck.
Just the two of us, for a little while at least.


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This is a crowd-pleasing recipe in my house that also fits nicely in my diet. That's a huge win in my book! I made these for myself when we did family pizza night, and my kids started asking for my food instead of the pizza. Now it's a staple meal for us.
Any time you are cooking with zucchini as a replacement for bread, you want to manage the moisture. After you hollow out the zucchini, which is much easier than it sounds — trust me, you need to add salt and bake them in the oven. This will get rid of extra moisture and not result in runny pizza bowls — definitely not what we are after. If you want extra flavor, you can add some garlic powder as well. Not a fan of the rubbery zucchini texture? Drizzle with a little bit of olive oil.
Once the zucchini are cooked, finishing the recipe is as easy or complex as you'd like to make it. I like to load up on veggies and meats, but the kiddos prefer plain cheese with bacon bits.
Let me know if you give this recipe a try. I've created a downloadable PDF if you prefer to print it out.
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Focused on building resilience and thriving in complexity
Hi ,
Welcome to the inaugural newsletter! I'm glad you're here.
I had the pleasure of being interviewed by Deepa Kartha, CEO of Journyz, and talk about one of my favorite HSD (Human Systems Dynamics) methods, namely the Landscape Diagram. I use it to make better decisions in my career, work, and for my family. Click on the short video above to learn more!
I'm being hosted by Agile Dialogue, Mississauga to present an introduction to the Agile Fluency Model and share my experience implementing it in my coaching engagements. The event is free and requires an RSVP here.
I'm so proud of this work and collaboration! It's chock full of studies and practical advice that has taken Norman, Christophe, and me a while to gather over many nights and weekends.
If you would like a free copy of the book, reply to this email with your physical address and I'll get it shipped directly from the printer. The only request I have is for you to write a review for it on Amazon.
I've written about Pattern Spotting and practicing Gratitude. More blog posts and practical tips on their way!
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Weight | 0.23 kg |
Dimensions | 12 × 33 × 5 cm |
India Painted Incense Plate – Green Agate
Made from sturdy mango wood, this incense dish is painted in a dreamy lustrous green onyx color, beautiful as a starry sky. Two sticks of incense can be placed at the same time at both ends, and different flavors can be mixed to fill the space with your favorite aroma, helping you focus on meditation and meditation.
Its size perfectly covers the incense, so it is not afraid of the incense ash staining the environment, which is very suitable for who often use incense. The texture of the incense dish is also easy to clean, just wipe it with a paper towel.
In addition to ignite incense, it can also be used as a small tray for different personal items such as crystals, ornaments, etc. Beautiful and versatile incense plate, good for personal use or gifting.
Size: 30 x 10cm
Material: Mango wood
Manufacture: India
4 in stock
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News in Brief 30 December 2020
This is the News in Brief from the United Nations.
WHO urges greater COVID-19 surveillance
In a year already defined by the COVID-19 pandemic, a new higher transmissible mutation has prompted the World Health Organization (WHO) on Wednesday to call on African countries to boost their surveillance of the virus.
South Africa recently detected the new variant, which is likely linked to the ongoing surge of COVID-19 infections in the country but appears to transmit more easily.
WHO Regional Director for Africa Matshidiso Moeti commented that, while new COVID-19 variants are common, the news from South Africa was "very concerning", adding that investigations are underway to understand the new mutation's behaviour and steer the response accordingly.
Nigeria is also carrying out more investigations on a variant it identified in samples collected in August and October.
Blackwater pardons an "affront to justice" – UN experts
And in the United States, five independent UN experts railed against President Donald Trump's pardoning of four Blackwater Worldwide contractors who were convicted in 2015 for war crimes in Iraq.
The private security contractors were prosecuted and found guilty of multiple criminal acts committed during a 2007 massacre at Nisour Square in Baghdad, including the killings of 17 unarmed civilians.
President Trump pardoned the four after the US courts found them guilty in 2015 of first-degree murder and manslaughter.
The UN experts, who comprise the Working Group on the use of mercenaries and are part of the Special Procedures of the UN Human Rights Council, said the 22 December pardons violated US obligations under international law.
Chairperson Jelena Aparac upheld that they are "an affront to justice and to the victims of the Nisour Square massacre and their families".
The experts also called on all States parties to the Geneva Conventions to condemn the pardons.
Refugee evacuations 'crucial lifeline'
As the year draws to a close, the UN Refugee Agency's last evacuation flight in 2020 has safely transported 130 vulnerable asylum seekers from Libya to Rwanda.
The aircraft left the capital, Tripoli, on Tuesday afternoon, with women, men and children from Eritrea, Sudan, Ethiopia and Somalia on board.
While most of them had been living in urban areas, many had previously been held in detention centres across the country.
The UN agency's chief of mission in Libya, Jean-Paul Cavalieri, said that the evacuations have proven to be "a crucial lifeline for vulnerable refugees" and appealed to the international community "to provide greater support to these populations".
New flights will resume in 2021.
Liz Scaffidi, UN News.
WHO urges greater COVID-19 surveillance
Blackwater pardons an "affront to justice" – UN experts
Refugee evacuations 'crucial lifeline'


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The Role of Strengths and Abilities in the IEP
The Individuals with Disabilities Education Act of 2004 repeatedly emphasizes the importance of focusing on the student's strengths in the development of the Individualized Education Program (IEP). Decades of research has revealed the necessity to maintain high expectations, to give students with disabilities access to the general curriculum with the appropriate supports, and to educate students to the maximum extent possible alongside their typical peers. The IEP team can ensure that these criteria for high expectations are met most appropriately when they recognize both the student's strengths and needs, and are able to match this information to various learning opportunities within the school setting.
Take, for example, a young student with a severe learning disability who loves science and is fascinated by listening to historical facts and biographies. Perhaps this student benefits from part of his day being spent in a special education resource room to receive intensive support in math. The IEP team as a whole agrees that this placement is appropriate, but wants to consider a regular classroom setting for other portions of the school day. A decision to place this student in a regular science and history class with the appropriate supports and services is one that will likely prove beneficial because the team is capitalizing on the student's strengths and interests while taking into account the learning and social needs the student has as well.
Consider the student who has an emotional disability that results in her having a difficult time expressing herself when she becomes anxious. Her threshold for anxiety is quite low which quickly results in her "shutting down" and completely disengaging from her learning activities. The team knows, however, that this student has a strong interest and natural talent in drawing and creating other artwork. The team can incorporate the opportunity for the student to express herself when she becomes anxious by creating images on paper or using other art media to alleviate her distress and help her return to her learning more quickly.
The energy and focus that IEP teams generate towards providing the appropriate educational program for students with disabilities are well-spent when considerations such as these are made. Students are more successful and engaged in learning, school staff feel confident administering a quality program and seeing their students succeed, and parents see the clear evidence of progress and the continued or renewed presence of a love of learning that can so easily fade away.
The opportunities to embed a student's strengths into his or her IEP are endless. For many students, doing so may mean the difference between making strong progress towards the general curriculum and witnessing the gap in achievement become disappointingly wider. Focusing on students' strengths and allowing those strengths to guide IEP decision-making is certain to make a difference in any student's school and life experience.
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To Deter Iranian Attacks on U.S. Troops, Pentagon Orders B-52 Flights to Middle East
"Iranians should be confused about how to interpret signals from a president whose policies and public statements have been so incoherent, impulsive and mercurial," stated Karim Sadjadpour, an elderly other at the Carnegie Endowment for International Peace. "I suspect their goal is to simply wait out the mad man until Biden comes."
In an instruction with a tiny team of press reporters prior to the objective on Thursday, an elderly army authorities stated American knowledge experts had actually discovered "planning going on" — consisting of prep work for feasible rocket strikes or even worse — by Iran as well as Shia militias in Iraq that it sustains.
Over the previous year, Iranian-straightened proxies in Iraq have actually performed greater than 50 rocket strikes on bases where United States soldiers are housed, along with on the American Embassy in Baghdad, as well as released 90 strikes on convoys lugging materials to American soldiers, according to the Pentagon.
"In short, Iran is using Iraq as its proxy battleground against the United States, with Iran's ultimate objective being to eject the United States and our forces from Iraq and the broader Middle East," General McKenzie stated last month throughout an online meeting on the Middle East.
Many elderly United States leaders as well as knowledge experts claim that considering that the fatality of General Suleimani, that ran the elite Quds pressure of the Islamic Revolutionary Guards Corps, Iran might not work out the very same level of control over Iranian-backed Shia militias in Iraq that it as soon as did. Some of these militias can snap without Tehran's true blessing, potentially provoking rise as well as an armed forces exchange in between Iran as well as the United States.
The elderly army authorities, that talked on the problem of privacy to explain procedures as well as knowledge analyses, did not point out any kind of certain proof of a bigger, brewing assault versus American workers. But the authorities stated army experts examined that the probability of Iran or its proxies overlooking the dangers of such a strike were greater than typical.
This analysis motivated the extra deterrent steps, the authorities stated.
The United States has additionally sent off an added armada of strike airplane to Saudi Arabia in current weeks. And the carrier Nimitz, which had actually left the Middle East on Nov. 15 to join a marine workout off the coastline of India, went back to the area 10 days later on, seemingly to give security to the a number of thousand pressures that Mr. Trump gotten to take out from Afghanistan as well as Iraq.


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Book Review: Hope Overcomes Suffering
By Dr. Ted Baehr, Publisher
Book Title: LIVING HOPE: AWAKENING TO FAITH, PEACE AND PURPOSE IN TOUGH TIMES
Author: Gerard Long
Publisher: Awakening to God Ministries
Release Date: June 2021
Gerard Long's book LIVING HOPE is a heart-rending, yet uplifting portrait of suffering and hope. Suffering has always been a great challenge to faith.
Gerard and his wife, Jean, have experienced incredible loss with the suicide of their son and the drowning death of their daughter, both children had so much to offer the world. Of course, these events shook them to the depth of the souls, but in the midst of their suffering, God touched them, and this book provides a unique lens through which we can better see and understand God in our pain.
While my wife, Lili, was suffering throughout the last year of her life, I would read her from this book, and even the most tragic events were written so inspiringly from a faith perspective that she wanted to hear more. By the way, Lili, hated hospital movies and books. This is not a hospital book. This is about faith overcoming the world, the flesh and the devil. I finished the book after Lili died, and, in the midst of my grief, it reinvigorated my faith in Jesus Christ.
I recommend the book highly, because it will provide you comfort and hope and stir many to renew their faith in God and commitment to His plan for their life in the midst of the tragedy of our fallen world.
Years ago, the church had a fully developed theology of suffering. The subject of why bad things happen to good people has been neglected too long. Gerard's book re-establishes a biblical, faith-filled, encouraging, and uplifting view and understanding of suffering in the light of the reality of the eternal love of the One Triune God.
I could not recommend any book more than I can recommend LIVING HOPE. Every page is a blessing.
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What you listen to, watch, and read has power. Movieguide® wants to give you the resources to empower the good and the beautiful. But we can't do it alone. We need your support.
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Buy Cartridges Online USA
Cartridges Some of the more common ingredients used to "cut" the carts, or make them look lighter in color to portray higher-quality, include propylene glycol, vegetable glycerin, or MCT oil. High-quality cannabis distillate will generally have this transparent golden color with a thick consistency.
cartridge pre-filled with a gram or half-gram of cannabis oil. This oil contain various combinations of cannabinoids and terpenes extracted from cannabis.
How do vape pens work?
Vape cartridges work in conjunction with vape pen batteries. T You then inhale the vape smoke, which produces the effects of cannabis. Some vape batteries have multiple functions that enable temperature customization and dose management.
How Cannabis Cartridges Work
Using a vape pen is simple. Just press the button and inhale the vapor through the mouthpiece. This action automatically heats up the cartridge which allows you to vape instantly. Vape cartridges operate using vape pen batteries. A vape pen battery powers an atomizer in the cartridge which heats up the oil. The heating of the oil also activates its chemical compounds which are then inhaled by the user. More advanced vape pens have multiple functions that allow the user to control the temperature and dose.
Benefits of Cartridges Over Cannabis Flower
There are many reasons why so many people are using cannabis cartridges. First, vape pens are discreet. There is no smoke or lingering odors that could catch the attention of passersby. There are also many varieties to choose from. You can find cannabis oils in a wide range of flavors. As cartridges contain concentrated fillings, they are able to maintain their potency and flavor much longer compared to flower. Cannabis cartridges are also available in several varieties, such as plastic wick, Pax Pods, glass, and metal. The higher the quality of materials, the more developed and untainted the flavor.
Shop for Best Vape
At Pure Oasis, you will find a full range of highly potent cartridges to use with various portable, stationary, or disposable vaporizing devices. Our concentrated cannabis cartridges contain pure liquid THC oils derived from different strains of cannabis to deliver a rewarding vaping experience. Are you ready to try a vape pen for the first time or need replacement cartridges for your existing vaporizer? Shop our complete selection of cannabis cartridges today at Pure Oasis.
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Mumbai, Dec 8 (IANS) Actor Ashutosh Kulkarni has shared his deep connection with mountains, revealing how he explored Shivaji Maharaj's forts on his bike, and discovered different roads, ancient temples and beautiful places.
Several people are drawn to mountains for their serene beauty, the adventure they offer, peacefulness in their surroundings, outdoor activities such as hiking and skiing and the feeling of being closer to nature.
Ahead of International Mountain Day (December 11), Ashutosh shared memories of his favourite mountain holidays.
"When I was in school, my friends and I loved cycling around the mountains near Pune. It was so much fun. But as we grew up, life got busy, and we switched to riding bikes and cars. During lockdown, I brought back those good times and bought a nice bike. It was one of my best decisions.
"On my bike, I explored Shivaji Maharaj's forts and discovered so much -- different roads, ancient temples, and beautiful places I never noticed before while driving. I used Google Maps to find lakes and natural spots, leading me to many interesting places. After many solo trips and hikes in the mountains around Pune, I found the perfect spot to sit and relax. It's like a complete refreshment for me," Ashutosh said.
The actor is currently essaying Krishna Bihari Vajpayee in the show 'Atal', which airs on &TV.
Disclaimer: This story has not been edited by the Sakshi Post team and is auto-generated from syndicated feed.


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Obituaries » Roman García-Ayala
March 29, 1953 - November 13, 2022
GARCÍA-AYALA: Roman García-Ayala, 69 of New London CT, entered eternal life on Nov. 13, 2022 at home surrounded by his loving family. He was born March 29, 1953 in El Salvador, the son of the late Roman García-Elias and Isabel Ayala. Roman came to the US in 1990, settling in New London. He is survived by his loving wife of 37 years, Reina García, along with three children: Rene García-Valencia, Mirna Jenkins, and Julio García, as well as four grandchildren. His family will receive relatives and friends on Friday from 6 to 8 pm at the Impellitteri-Malia Funeral Home, 84 Montauk Ave. New London. On Saturday, a Mass of Christian Burial will be celebrated, at 12 pm in St. Mary Star of the Sea Church, 10 Huntington St., New London. Interment to follow in Cedar Grove Cemetery, New London.


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Apple has come away successful from a battle with Russian telco Rostelecom, after the latter sent out false route announcements to redirect traffic meant to the United States company's servers to the latter's network.
Network engineer Aftab Siddiqui at the Mutually Agreed Norms for Routing Security (MANRS) project wrote that Rostelecom started announcing routes for part of Apple's network through the border gateway protocol (BGP) for just over 12 hours, on July 26-27.
"The effect was that Internet users in parts of the Internet trying to connect to Apple's services may have been redirected to the Rostelecom network," Siddiqui wrote.
Siddiqui said the Apple internet protocol address block affected by the apparent traffic hijack by Rostelecom autonomous system (AS) 12389 network was the 22.214.171.124/19 allocated to the US tech giant..
A /19 IP block contains 8192 network addresses, and Siddiqui said the prefix is part of Apple's larger 188.8.131.52/8 allocation.
Apple does not use Route Origin Authorisation (ROA), which uses resource public key infrastructure (RPKI) cryptographically signed objects to attest that an origin AS is allowed to announce network prefixes.
Validating ROA prevents false BGP route announcements between networks, which avoids sending traffic to the wrong destination.
WIthout ROA, Siddiqui said the only option during a route hijack is to announce more specific routes.
"This is exactly what Apple Engineering did today; upon learning about the hijack, it started announcing 126.96.36.199/21 to direct traffic toward AS714," Siddiqui said.
AS714 is assigned to Apple Engineering, and Rostelecom started to announce a route to that network at the same time as well.
Rostelecom's route announcements spread across the globe, with BGP monitoring systems picking them up and flagging them as potential traffic hijacking attempts.
Siddiqui pointed out that this not the first time Rostelecom has hijacked routes.
In 2020, Qrator Labs noted that Rostelecom's AS12389 announced prefixes for many well-known companies such as Akamai, Cloudflare, Hetzner, Digital Ocean, and Amazon Web Services.
Rostelecom has not provided an explanation as to the mis-orgination of Apple Engineering's network routes.
Apple has been contacted for comment on the event, which services were affected and if any traffic went through Rostelecom's network.
BGP traffic hijacks have long been a scourge of the Internet.
Some of the incidents have been accidental misconfigurations, like the 2004 event in which Turkish provider TTNet pretended to be the whole of the Internet, which meant that millions of users were unable to reach legitimate websites for hours on end.
Others, like the 2018 hijack by Iran Telecommunications of Telegram prefixes suggest nation-state involvement.
Criminals have also been known to use BGP hijacking to steal traffic, as in February this year when South Korean crypto currency platform KlaySwap was attacked and almost US$2 million funds were taken.
Siddiqui said that network operators have a responsibility to ensure a globally robust and secure routing infrastructure, which includes having valid ROAs for all of their resources.
"Your network's safety depends on a routing infrastructure that stops bad actors and mitigate accidental misconfigurations that wreak havoc on the Internet.
The more network operators work together, the fewer incidents there will be, and the less damage they can do," Siddiqui said.


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Fate Therapeutics Announces Preclinical Publication Highlighting Derivation of CD8αβ T Cells from TCR-CAR+ Induced Pluripotent Stem Cells
TCR-CAR+ iPSC-derived CD8αβ T Cells Induced Complete and Durable Responses In Vivo in Systemic Leukemia Model
Cell-surface Markers, Gene Transcription Profile, and In Vivo Anti-tumor Activity of TCR-CAR+ iPSC-derived CD8αβ T Cells Compared Favorably with Healthy-donor Peripheral Blood CAR T Cells
Phase 1 Study Ongoing of First-ever iPSC-derived T-cell Product Candidate FT819 for Off-the-shelf Treatment of Patients with Relapsed / Refractory B-cell Malignancies
"Scientists have previously differentiated induced pluripotent stem cells to form CAR T cells, however, it was observed that premature αβTCR or constitutive CAR expression resulted in the derivation of innate-like T cells that do not acquire the phenotype nor exhibit the function of conventional CD8αβ T cells," said Dr. Sadelain. "Our published findings are the first to show the generation of iPSC-derived CD8αβ CAR T cells lacking a TCR, where timed and calibrated expression of the CAR in place of the TCR successfully drove T-cell maturation and promoted the acquisition of a transcriptional and functional profile more closely resembling that of natural CD8αβ T cells."
The mass production of TCR-CAR+ CD8αβ T cells from master engineered iPSC lines is a promising approach for development of off-the-shelf, cell-based cancer immunotherapies. Through a systematic assessment of factors that affect T-cell lineage commitment and induce adaptive T-cell formation, the researchers discovered that integrating the CAR construct into the TRAC locus delayed its expression and drove T-cell lineage commitment, and that regulation of CAR signaling strength promoted the generation of CD4+CD8+ double-positive cells mimicking thymic development in the absence of a TCR. Subsequent stimulation of the CAR matured the double-positive population into single-positive CD8αβ T cells with a phenotype highly correlated with peripheral blood CD8αβ effector T cells and distinct from γδ T cells and natural killer cells. Preclinical studies showed that iPSC-derived TCR-CAR+ CD8αβ T cells were able to repeatedly lyse tumor cells in vitro and durably control leukemia in vivo, with persistence in the bone marrow, spleen, and blood, in a systemic NALM6 leukemia model.
"These published findings continue to support our unique ability to generate TCR-CAR+ CD8αβ T cells from master engineered iPSC lines that exhibit a phenotypic profile and anti-tumor activity comparable to healthy donor-derived peripheral blood CAR T cells in preclinical model systems," said
The Company is conducting a multicenter Phase 1 study of FT819, the first T-cell therapy manufactured from a clonal master iPSC line to undergo clinical investigation. The product candidate's clonal engineered master iPSC line is created from a single iPSC that has a novel CD19-targeted 1XX CAR construct integrated into the TRAC locus, ensuring complete bi-allelic disruption of TCR expression to prevent graft-versus-host disease and promoting uniform CAR expression for enhanced anti-tumor activity. Dose escalation is currently ongoing in single-dose and multi-dose escalation cohorts for relapsed / refractory B-cell malignancies.
Pursuant to a license agreement with MSK,
About Fate Therapeutics' iPSC Product Platform
The Company's proprietary induced pluripotent stem cell (iPSC) product platform enables mass production of off-the-shelf, engineered, homogeneous cell products that are designed to be administered with multiple doses to deliver more effective pharmacologic activity, including in combination with other cancer treatments. Human iPSCs possess the unique dual properties of unlimited self-renewal and differentiation potential into all cell types of the body. The Company's first-of-kind approach involves engineering human iPSCs in a one-time genetic modification event and selecting a single engineered iPSC for maintenance as a clonal master iPSC line. Analogous to master cell lines used to manufacture biopharmaceutical drug products such as monoclonal antibodies, clonal master iPSC lines are a renewable source for manufacturing cell therapy products which are well-defined and uniform in composition, can be mass produced at significant scale in a cost-effective manner, and can be delivered off-the-shelf for patient treatment. As a result, the Company's platform is uniquely designed to overcome numerous limitations associated with the production of cell therapies using patient- or donor-sourced cells, which is logistically complex and expensive and is subject to batch-to-batch and cell-to-cell variability that can affect clinical safety and efficacy. Fate Therapeutics' iPSC product platform is supported by an intellectual property portfolio of over 350 issued patents and 150 pending patent applications.
About FT819
FT819 is an investigational, universal, off-the-shelf, T-cell receptor (TCR)-less CD19 chimeric antigen receptor (CAR) T-cell cancer immunotherapy derived from a clonal master induced pluripotent stem cell (iPSC) line, which is engineered with the following features designed to improve the safety and efficacy of CAR19 T-cell therapy: a novel 1XX CAR signaling domain, which has been shown to extend T-cell effector function without eliciting exhaustion; integration of the CAR19 transgene directly into the T-cell receptor alpha constant (TRAC) locus, which has been shown to promote uniform CAR19 expression and enhanced T-cell potency; and complete bi-allelic disruption of TCR expression for the prevention of graft-versus-host disease. FT819 demonstrated antigen-specific cytolytic activity in vitro against CD19-expressing leukemia and lymphoma cell lines comparable to that of primary CAR T cells, and persisted and maintained tumor clearance in the bone marrow in an in vivo disseminated xenograft model of lymphoblastic leukemia. FT819 is being investigated in a multicenter Phase 1 clinical trial for the treatment of relapsed / refractory B-cell malignancies, including B-cell lymphoma, chronic lymphocytic leukemia, and acute lymphoblastic leukemia (NCT04629729).
Forward-Looking Statements
This release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 including statements regarding the advancement of and plans related to the Company's product candidates, clinical studies and preclinical research and development programs, the Company's progress, plans and timelines for the manufacture and clinical investigation of its product candidates, the Company's initiation and continuation of enrollment in its clinical trials including additional dose cohorts in ongoing clinical trials of its product candidates, the therapeutic and market potential of the Company's product candidates, and the Company's clinical development strategy, including for its product candidate FT819. These and any other forward-looking statements in this release are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, the risk that the Company's product candidates may not demonstrate the requisite safety or efficacy to warrant further development or to achieve regulatory approval, the risk that results observed in prior studies of the Company's product candidates, including preclinical studies and clinical trials, will not be observed in ongoing or future studies involving these product candidates, the risk of a delay or difficulties in the manufacturing of the Company's product candidates or in the initiation and conduct of, or enrollment of patients in, any clinical trials, the risk that the Company may cease or delay preclinical or clinical development of any of its product candidates for a variety of reasons (including requirements that may be imposed by regulatory authorities on the initiation or conduct of clinical trials, changes in the therapeutic, regulatory, or competitive landscape for which the Company's product candidates are being developed, the amount and type of data to be generated or otherwise to support regulatory approval, difficulties or delays in patient enrollment and continuation in the Company's ongoing and planned clinical trials, difficulties in manufacturing or supplying the Company's product candidates for clinical testing, and any adverse events or other negative results that may be observed during preclinical or clinical development), the risk that results observed in preclinical studies of FT819 may not be replicated in ongoing or future clinical trials, and the risk that FT819 may not produce therapeutic benefits or may cause other unanticipated adverse effects. For a discussion of other risks and uncertainties, and other important factors, any of which could cause the Company's actual results to differ from those contained in the forward-looking statements, see the risks and uncertainties detailed in the Company's periodic filings with the
Stern Investor Relations, Inc.
Source: Fate Therapeutics, Inc.


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A 43-year-old San Francisco man is proudly finishing plates of leftover food at local restaurants, and no one's last bite is safe. In an interview with Deadspin, the unabashed moocher congratulates himself for flouting social norms at establishments like Swan Oyster Depot. At least the restaurant choice betrays some taste, even if the behavior is arguably tasteless?
"The seated people ahead of us had ordered sashimi," says the man, who identifies himself by the first name "Alex" and who says he works in finance. "They had eaten some of it but had left a bunch of it out. We're kinda hungry. It's the morning. It's just going to be thrown away. So I didn't ask or anything … I just went up and I grabbed it and popped one in my mouth..."
Why? Alex's answer is basically "why not?" He's never gotten sick, and he basically thinks that social norms are stupid, don't apply to him, or both.
But Alex isn't a total, lawless rogue: He has a few rules. He wouldn't necessarily try his trick at a fine dining establishment, and he won't steal bites from a shared bowl of curry that had been discarded, he says. But leftover guacamole? He'll grab a chip and dip in.
Waiters don't approve, Alex concedes, and he's learned not to ask them if he can give it a go: better to ask forgiveness rather than permission, he says. But the philosophy is simple (and Alex is, unsurprisingly, an avowed Libertarian). "I feel like this is a victimless crime. As a matter of fact, I think chefs don't want to see food go to waste. I don't think there's any negativity to be doing this."
Alex even has a girlfriend (or says he does) who has taken up the habit herself, though for different reasons. She hates to see food go to waste, while he's more concerned with getting an extra bite to eat (and, it sounds like, a bit of a rise out of people).
Alex's dining habits might come across as a sign of these entitled times, a parable of male arrogance in San Francisco 2019. But this quirky behavior might be a throwback to a more free-spirited time in San Francisco. Alex is an SF native, after all. And he doesn't care — and in fact enjoys — that his dining might scandalize others. Asked by Deadspin if he's worried about outrage, Alex said:
"I live in San Francisco. I'm from San Francisco. I've dealt with outrage my whole life."


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Posted on June 1, 2022 at 12:02 PM by Becky Burnside
Temperatures have warmed up, the grass is green, and leaves are out, making June a great time to get outdoors again.
Whether you want to take part in a new festival celebrating parks and the arts, spend some family time participating in activities ranging from geocaching and enjoying s'mores to playing bingo, camping, or observing Juneteenth as our newest national holiday, or doing some free or overnight fishing, JCPRD has a June event for you!
Events marked below with a blue asterisk (*) require preregistration, while the other listings welcome walk-ins.
While JCPRD's 50 Plus programs are primarily for ages 50 or older, interested parties who have not yet reached that magic age may still be able to attend. Persons 18 and older who are interested in a 50 Plus program are invited to call the 50 Plus Department at 913-826-2975 for space availability.
Friday, June 3
Saturday, June 4
Saturday, June 4 and Sunday June 5
Tuesday, June 7
Saturday, June 11
Thursday, June 16
Saturday, June 18
Friday, June 24
Saturday, June 25