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A service of the U.S. National Library of Medicine
National Institutes of Health
Environment Trumps Genes at Shaping Immune System: Study
In twins study, microbes, toxins, diet and dental hygiene explained 75 percent of differences
Thursday, January 15, 2015THURSDAY, Jan. 15, 2015 (HealthDay News) -- Environment plays a larger role than genes in shaping people's immune systems, a new study suggests.
Researchers compared 78 pairs of identical twins -- who are nearly genetically the same -- and 27 pairs of nonidentical twins, who have about 50 percent of their genes in common.
Three-quarters of the immune system differences between the twins were due to environmental influences such as previous exposure to microbes or toxins, vaccinations, diet and dental hygiene.
Among identical twins, environmental effects on the immune system were stronger among those 60 and older than among those younger than 20, the Stanford University School of Medicine researchers found.
The study was published Jan. 15 in the journal Cell.
"Nonheritable influences, particularly microbes, seem to play a huge role in driving immune variation," senior study author Mark Davis, a professor of microbiology and immunology and director of Stanford's Institute for Immunity, Transplantation and Infection, said in a university news release.
"At least for the first 20 or so years of your life, when your immune system is maturing, this amazing system appears able to adapt to wildly different environmental conditions. A healthy human immune system continually adapts to its encounters with hostile pathogens, friendly gut microbes, nutritional components and more, overshadowing the influences of most heritable factors," he explained.
SOURCE: Stanford University, news release, Jan. 15, 2015
Copyright (c) 2015 HealthDay. All rights reserved.
- More Health News on:
- Environmental Health
- Immune System and Disorders


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Do not hesitage to give us a call. We are an expert team and we are happy to help you.
+31 85 4018272
+27 83 646 9774
The Tanzania Wildlife Breakaway Lodge Group Safari lets you explore the best game areas in Tanzania, where the wildlife sightings are plentiful. You will visit the world-famous Serengeti National Park, Tarangire National Park, the Ngorongoro Crater and many more.
Lake Manyara National Park, Tarangire National Park, Serengeti National Park, Wildebeest Migration, Ngorongoro Crater
Group Size: Minimum 4, Maximum 12 (Guaranteed departures with no minimum pax available)
Travel Times and Distance: All travelling times are affected by road conditions, border crossings, detours and weather conditions, therefore on certain days travelling times may be longer than anticipated especially where there is a lot of distance to be covered. Please keep in mind that the time it takes to travel 100 km in your home country is not equivalent to the time it takes to travel 100 km on African roads, therefore we encourage you to sit back and enjoy the spectacular scenery Africa has to offer. Where possible additional stops will be made to ensure your travelling comfort at all times.
Meals: Breakfast and dinner will be prepared by the lodge where you are staying. They will also prepare lunch or a lunch pack depending on the itinerary for the day. Please advise us of any special dietary requirements in advance.
Travel Insurance: Please note that travel and cancellation insurance is mandatory for every guest travelling with African Travels. All insurance is solely the responsibility of our guests. Please ensure you arrange your own insurance with protection for the full duration of your journey to cover personal injury, damage and loss of personal items including but not limited to camera equipment and other electronic items, medical expenses, repatriation expenses and loss of luggage, etc. Please speak to us if you require assistance.
Arusha – Arusha
Start at time of pick-up from airport upon arrival on day 1
You will be collected from the airport and transferred to your Boutique hotel in the heart of Arusha. Depending on your arrival time, you will have an opportunity to explore the grounds, go for a dip in the swimming pool or partake in any of the offered additional activities available.
Your safari begins after breakfast this morning. Our first stop is Arusha town, for any last minute purchases before we head off on an exciting safari experience! We will be in Tarangire National Park for lunch and an afternoon game drive. Tarangire is well known for its huge elephant population and baobab trees. It forms the centre of the annual migratory cycle that includes up to 3000 elephant, 25,000 wildebeest and 30,000 zebra.
In the late afternoon we arrive in the town of Arusha – the gateway to the Kilimanjaro National Park.
We head towards Lake Manyara National Park for an early morning game drive. The spectacular national park is located at the north-western corner of Lake Manyara, a hallow soda lake, which lies at the foot of the Great Rift Valley's western escarpment. Manyara NP is not only known for its large flocks of flamingos, but also for the elusive tree climbing lions.
After breakfast we drive up the Rift Valley escarpment towards the world famous Ngorongoro Crater. For many, this wildlife spectacle is the pinnacle of their safari experience. The Ngorongoro Crater boasts all of the 'Big 5', including a small population of endangered black rhino. After a picnic lunch, we head towards the Serengeti through the stunning Southern Plains. This is the area that the Serengeti is best known for – the endless, undulating grass savannah with rocky outcrops that serve as isolated wildlife refuges.
Today you will be spending a full day game driving around the Seronera area of the Serengeti. The Serengeti is divided into three main areas: Seronera is the most central and accessible region and this is where the Park HQ is based, as well as most of the larger lodges and communal campsites. This part of the Serengeti is characterised by open plains of grassland, packed with animals. The Seronera River is the lifeblood of the Serengeti and this area is renowned for great game viewing all year round. It is also particularly good for lion and cheetah sightings, as well as the most elusive of all big cats, the leopard.
Today we retrace our steps with a morning game drive through the Serengeti followed by Picnic Lunch, before we continue through the Ngorongoro Conservation Area. En route we visit Olduvai Gorge.
After breakfast we explore the colourful town of Mto-wa-Mbu for some last minute pictures and curio shopping. Afterwards we head to Arusha where the tour will end. We hope to welcome you again on one of our African adventures!
Making your Travels Meaningful: The Grow Africa Foundation (163-738 NPO) is the responsible tourism initiative. The focus of Grow Africa is to make a positive impact on the environment, society and economy in the places we travel to. We do this by instigating and supporting local social and environmental projects.
Your booking makes a difference: With every booking to the value of R10,000 / US$1,000 / EUR1,000 or more a donation of R50 / US$5 / EUR5 will go to the Grow Africa Foundation. Click here to see the projects your booking is.
We are also proud members of Pack for a Purpose, a global initiative that allows you to make a lasting impact on the communities you visit. Use your excess luggage allowance to pack supplies needed by the Dingani Primary School in Zimbabwe. We'll then make sure it gets delivered to them.
My husband and I decided to do a safari for our honeymoon, after lots of research we chose Tanzania and Jenman safari's. We had high hopes for our first safari and first visit to Africa and it didn't disappoint. We can honestly say this was the best holiday we have ever been on and we are both well traveled. Our tour guides Jephter and Ibrahim were just brilliant, they both knew there stuff and were able to locate the animals each day. We saw lions and their cubs (13 cubs) leopards, elephants, cheetah with cub and so much more, we even got see lions on their honeymoon :). We cannot thank Jephter and Ibrahim enough they were so so great made the tour. We chose to go for the mid range accommodation option, all of which were lovely all staff so welcoming, great facilities even in the middle of the Serengetti. It was amazing to be lieing in bed listening to amazing wildlife right outside, zebras, hyenas and even a hippopotamus, we felt so safe with the massi walking around at night keeping look out. If anyone is considering booking Wildlife Breakway Tanzania with Jenman we both would highly recommend it and can't wait to go back.
We have recently returned from our safari in Tanzania and I wanted to say how perfect everything was and how safe we felt. We had Elisha as our tour guide. He was amazing. Not only was he extremely knowledgable but he was interested in sharing his knowledge. He never failed so show interest in answering our questions. Nothing was too much for him even when we had had a very long day visiting Ngoro Ngoro Crater and then driving onto Serengetti. Elisha heard there was a sighting of a leopard up a tree. He turned the Toyota round and headed in the other direction just so we could see the leopard. We did see it and we also saw it come down the tree! So exciting. And this was how the whole safari was. One amazing thing after another, all beautifully organised – the lodges and camp welcoming, clean and interesting, and even the food was excellent. I was brought up in Kenya and have been on several safaris but this safari far excelled anything I had anticipated. I want to thank Jenman for putting together the itinerary and even with long days driving it was so inspiring with Elisha always there with his knowledge. Elisha is also an excellent driver. Always taking care and thinking of the passengers as we drove along the more than potholed roads.
Thanks so much.
We went on the Jenman Tanzania breakaway safari in Jan 2013. It was amazing! The weather was great, we saw the big 5 plus other animals too, and the landscape was stunning. Jenman exceeded our expectations in terms of their Safari guide. Charmy, our guide, was knowledgeable, experienced, and personable.
We had a blast.
Hi Johan, The Lavery party would like to thank you most sincerely for a wonderful trip. Alex made the trip for us His friendly approach and amazing knowledge of wildlife brought the trip to life for us. You have a gem there.
We would like to view the Mara crossing in November and would really appreciate having Alex with us again. By the way your new van created interest wherever we went .It was roomy and we had great space to view the animals
Kind Regards, Terry
I just thought you may like to hear from us to let you know how we are going. It would take me days of writing to tell you everything but suffice to say our expectations have been greatly exceeded to say the least. Africa is truly a beautiful and amazing place with exciting things to see around every corner. I can't speak highly enough of our guides, Vincent in Uganda and George in Tanzania, who were very friendly, extremely knowledgeable, flexible and a lot of fun to be with. They bring the whole experience to a high level of enjoyment and we would have been lost without them. Also, the places we stayed were brilliant and the staff attentive and jovial. We enjoyed their company a great deal. They couldn't do enough for us. The other thing I have been really impressed with is the fact that we have been able to get extremely close to the animals and birds and they are totally unfussed by our presence which translates into the most amazing photo and video opportunities. This is because, as our guides say, the animals "know the deal". Obviously everyone is doing the right thing and respecting the animals space.
So now we have sadly farewelled Zambia and are in the A'Zambezi River Lodge (another amazing place on this beautiful river) with 7 warthogs grazing on the lawn below our balcony. Don't see that very often in Australia! We have met our group ( only 5 guests and all from Australia including 2 from our own home town!) and our guide, Jonathon, who seems to have a real passion for his job and this country so we are looking forward to the next 21 days on our Southern Experience. We met Corne twice in Tanzania and what a lovely man he was so please give him our very best regards. Warmest regards to yourself as well and hopefully we'll catch up with you when you come to Adelaide.
PS. I nearly forgot to thank you for your recommendation to have a sunset cruise on the Ra-Ikane. A beautiful boat with a very romantic atmosphere. We felt very spoilt indeed.
Warmest regards, Kay and Mauro

subset: commoncrawl


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That's what I was playing on my TV when England took on Costa Rica in their final group game in Brazil in 2014. Little did I understand that in fact, it was England that would be going home after that game and the central American football team that were the competition's dark horses. Their team was full of rebels and trendy heroes that took the grades guide and ripped it to pieces.
Football World Cup fans from all over the world are called to book Football World Cup tickets from our online platform WorldWideTicketsandHospitality.com Football fans can book Spain Vs Costa Rica Tickets on our website at exclusively discounted prices.
Costa Rica arrived in Brazil as the 28th-ranked country in a group with Uruguay at 7, Italy at 9 and England at 10, but did that stop them? Not a chance. With an unreliable but exciting Keylor Navas between the sticks, all-time top scorekeeper Bryan Ruiz leading the line. And ex-Arsenal speedster Joel Campbell burning down the wing gave the big boys in Group D a real surprise.
The 2014 Football World Cup group phase
England knew they had to get a result from their first two games with an easy final game against Costa Rica. However, a couple of hours before Daniel Sturridge counted against the Italians, the Costa Rica FIFA World Cup team drew off a dazzling 3-1 win over the Uruguay football team to blow Group D wide open. And put themselves top going into matchday 2.
This is where it started to get gluey for England and Roy Hodgson to lose to Uruguay and that would be attractive much that. Sadly, Hodgson could do nothing as two goals from a bitey Luis Suarez sent us back home after just 180 minutes of the Football World Cup. Let's pray it's different in Russia. But what's that? Costa Rica set the cat between the pigeons and made the world sit up as Bryan Ruiz ruled past Gianluigi Buffon to give them a narrow win over the Italians.
By the final group game of World Cup Brazil; to everyone's astonishment, Costa Rica was already capable and England was playing for whatever arrogance they had left. Meanwhile, it was left to a straight shootout between Italy and Uruguay football teams, winner goes through, loser goes home. But Costa Rica wasn't ended. For more to know about Football World Cup Tickets Click here.
A draw was enough to promise them the top spot and the 0-0 in this game was sufficient. Despite it being one of the worst FIFA World Cup games in living memory. Uruguay v Italy football team was a pretty boring 1-0 victory for the South Americans to send them across, oh yes, apart from Suarez biting Giorgio Chiellini.
The last 16 of Brazil FIFA World Cup 2014
Right, now it was down to the serious business of the knockout rounds. Costa Rica Football World Cup had already enthusiastically exceeded everyone's hopes especially England's by topping their group and in doing so were handed a positive draw for the last 16. Greece had pretended some of their 2004 Euro-winning soul to finish second in Group C ahead of Ivory Coast by thrashing them 2-1 in the final game.
After Ruiz counted another World Cup goal to put his nation ahead, the fans thought they were heading to the quarters until Sokratis Papastathopoulos' injury-time equaliser. Extra-time passed with little incident and then it came down to the feared penalty shootout. The Ticos knew they could make history by reaching the FIFA World Cup quarters for the first time if they overwhelmed the Greeks.
All nine penalty takers counted until Navas wrote his name into Costa Rican football history by saving the 10th penalty and permitting Michael Umana to step up and send them into new ground. This was unexplored land for the brave nation of under five million people. They were up against football titans Holland for a place in the 2014 FIFA World Cup semi-final. But again, their administration and energy achieved the keep the Oranje out for another 120 minutes.
Penalties were about to happen but not before Louis Van Gaal drew on a decision-making masterstroke. He represented goalkeeper Tim Krul in added time after 120 minutes and he saved two Costa Rican penalties to tip them out. Pandemonium for Holland, heartbreak for Costa Rica World Cup fans. Ah well, at least you know that Holland would have crushed England on penalties too.
Costa Rica's chances to win Qatar Football World Cup and how far will they go
The mainstream of Los Ticos' World Cup attendances has come this century and they've only missed one competition since 1998, though they don't often last too long, bowing out at the group phases. But fans will think of 2014 when they topped their group ahead of Uruguay, Italy and England en route to the quarter-finals where they misplaced to the Netherlands on penalties a game evoked for Tim Krul being subbed on for the shootout.
So, can Costa Rica go well in Qatar World Cup? You can find Costa Rica at 500/1 to win the World Cup this winter. Although Costa Rica may not be among the choices to win the Football World Cup, there is an opportunity that their starting probabilities are so high as they were the last side to secure their spot in Qatar. For more to know about Costa Rica Football World Cup team Click here.
As one of the top Concacaf squads, Costa Rica entered World Cup qualifying in the third and final round together with Mexico, USA, Jamaica and Honduras. But that didn't pledge them a good chance of qualifying. The third round of Concacaf qualifying was a close affair with just three points untying the top four, three of whom automatically qualified for the FIFA World Cup.
Costa Rica was the unfortunate fourth, finishing behind the third-placed USA on goal difference having beat the Americans on the final day. With the second-best defence in the group, Costa Rica was left to be sorry their 13 goals counted in 14 games. As a result of their fourth-placed finish, Costa Rica progressed to the inter-confederation play-offs against the OFC playoff winner and beat New Zealand to lock their spot at the Qatar Football World Cup.
The third round was much better and Iran only released four points from their 10 games to top Group A, two points clear of second-placed South Korea with both teams qualifying for the 2022 mega football event. Costa Rica's possible path to the 2022 Football World Cup final. As one of the unknown teams when the draw was made, Costa Rica was positioned in Pot 4 and had to wait a long time to find out their possible group.
It could have gone improved. Costa Rica was positioned in Group E alongside former world champions Spain and Germany, as well as a complicated Japan football team needful a lot to make it out of the group phase. They start their FIFA World Cup group phase against Spain, before games against Japan and lastly Germany. The games will be divided between Al Rayyan, Doha and Al Khor.
Paris Saint-German could take Spain Football World Cup player Pablo Sarabia
Following Kylian Mbappe's renewal, the bulk is on Paris Saint-Germain to redesign their team and deliver a competitive squad next season. While several players may find themselves, victims of that process, several football clubs are likely to see market breaks at the Parc des Princes. According to sports media in France, as accepted by Mundo Deportivo.
Pablo Sarabia may be on his way back to the Spain football team. His last stop would be Atletico Madrid, who have earlier been connected with the wide-man before. Sarabia, 30, has relished a fine season for Sporting CP and returned from his loan to Paris. Perhaps more fittingly, he has become a vital part of Luis Enrique's Football World Cup squad.
Famous for his crosses, he has also subsidised 9 goals in his 22 international games. Despite that, journalist Ruben Uria explained that he knew nothing of the concentration at this point. Uria is well-linked in Madrid and it would be amazement if Atleti did move for him as they seem well-stocked with forwards for next season.
We are offering FIFA World Cup Tickets football admirers can get World Cup Tickets through our trusted online ticketing marketplace. Worldwide tickets and hospitality is the most reliable source to book Football World Cup tickets. Sign up for the latest Ticket alert.


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Bridgestone Battlax fitted as original equipment on Kawasaki ZX-10R
Bridgestone's Battlax Racing Street RS10 tyre will be original equipment on Kawasaki's 2016 model Ninja ZX-10R, the top-ranked model in the Superbike World Championship 2015. The tyres, designed for use on public roads, also work to deliver strong sport performance. Employing MotoGP Technology refined during its decade-plus as tyre supplier to MotoGP, Bridgestone says its tyres will improve grip on dry road surfaces, improving lap times. They will also deliver impressive handling and stability for more comfortable driving on winding, open roads. The manufacturer says it plans to expand the global reach of the Battlax brand through efforts to promote its adoption as original equipment.


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The first climb of the day out of Orton, here looking back towards the Shap Fells |
Quick check of the map, straight onfor us into Great Asby Nature Reserve. |
Descending the twisting singletrack through the reserve, greasy with muddy tyres on the limestone. |
From Great Asby we rode by Breaks Hall and Bleatarn. |
Before dropping down to cross the River Eden on the edge of Warcop. |
We had our butties here at the convenient picnic bench, Warcop was very sleepy, hardly anyone about! |
Leaving Warcop we rode the bridleway through Blacksyke (very muddy) and on to Little Ormside. Then along the lane above to Ormside Mill. |
Where there's a ford! Luckily the water was low! |
Are we lost?...Only joking Ian! |
Another ford, this one at Rutter Force. Handy for washing the mud off our tyres! |
Looking East fro above Gaythorne Hall to the North Pennines. |


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Download Counter Strike 1.6
Genre: Action
Developer: Valve
Publisher: Valve
Release Date: 1 Nov, 2000
Counter Strike 1.6 is one of the most popular and influential first-person shooter games ever created. CS 1.6 was initially released for Half-Life in 1999. It soon became a huge success, gaining a passionate fanbase. Multiple sequels and spinoffs were created in response to its success.
Download Counter Strike 1.6 a multiplayer first-person shooter game. It pits two teams of players against each other: terrorists and counter-terrorists.
The game is played in rounds, with each round lasting up to two minutes. The objective of the game depends on the game mode.
Generally, one team tries to plant a bomb or defend hostages. The opponents are attempting to prevent the detonation of the bomb and rescue the people who have been taken hostage.
Players start each round with a limited amount of money, which can be used to purchase weapons, equipment, and other items. The amount of money earned in each round depends on how well the player performed in the previous round. In addition to money earned from winning rounds, players can also earn money by completing objectives.
One of the key features of CS 1.6 is its emphasis on teamwork and communication. Players must collaborate to reach their goals. Players can communicate with each other using in-game voice chat or text chat.
The game includes a wide variety of weapons, including pistols, shotguns, rifles, and grenades. Weapons have different strengths and weaknesses. To succeed, players must learn how to use them effectively. For example, pistols are generally less powerful than rifles, but they are also faster and more accurate at close range.
CS 1.6 includes a single-player campaign mode. In this mode, players can practice against bots in various scenarios. Multiplayer modes are also included.
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- In Bomb Defusal mode, terrorists must plant a bomb at one of two designated locations. Counter-terrorists must stop the bomb from being detonated. If it has already been put in place, they must take action to deactivate it.
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- Assassination is a game mode. One player is designated as a VIP. The objective is to escort this VIP to a safe location. The opposing team attempts to kill the VIP.
- Team Deathmatch is a mode where two teams compete. The aim is to get the most kills in the given time limit.
- Capture the Flag is a mode of play. Each team has a flag to defend. The goal is to capture the other team's flag and return it to their own base.
Counter Strike 1.6 was released in 2000. Its graphics and sound design were state-of-the-art for the time. However, these features may seem outdated by today's standards.
The game has intricate 3D visuals with a range of scenarios, including cities, business parks, and nature settings. The game's sound effects are highly realistic. Weapon sounds and ambient noises are accurate. This helps players to become immersed in the game's world.
Counter-Strike 1.6 has an advantage with its basic visuals. It can be used on many different PCs, even those that are older or not as powerful. This has helped keep the game accessible to a wide audience. It has been more than two decades since its initial release.
Counter-Strike 1.6 vs. Counter Strike Source vs. Counter Strike Global Offensive
CS 1.6 download was released in 2000. It has been followed by two major sequels: Counter Strike Source and Counter Strike Global Offensive. The series of games has distinct features and gameplay. Fans often debate which game is the superior one.
Counter Strike Source was released in 2004. It featured updated graphics and physics, as well as new maps and game modes. These updates made the game more exciting and enjoyable.
The gameplay mechanics were similar to cs 1 6 download. The graphics and physics were updated, however. This made the game feel more modern and polished.
Counter Strike Global Offensive, or CSGO, was released in 2012 and is the most recent game in the series. Like CS Source, CSGO features updated graphics and physics, as well as new maps and game modes. CSGO has added a few features. These include new weapons and equipment, improved matchmaking and ranking systems, and new game modes such as Battle Royale.
Although newer versions of the game have come out, Counter-Strike 1.6 still enjoys a strong following of devoted gamers. Some players enjoy the straightforward gameplay of the original game. Others are drawn to the game's historical significance and the nostalgia it evokes. It has been available for over twenty years.
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From a variety of sources, the popular gaming platform. To download and install the game from, simply follow these steps:
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– Release date November 18, 2013 (cs 1.6 full)
– cs 1.6 setup 256MB size
– 100% clean rip from Steam GCFs (Game cache files)
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– Working Dedicated and Listen server (Steam and non-Steam)
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– Full protection against all types of slow hacking servers
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– HLTV is also included and works
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– Playable on Internet and LAN
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500 mhz processor | 800 mhz processor |
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cs 1.6 game is a classic FPS game that has had a major impact on the gaming industry. Its focus on collaboration, dialogue, and tactical gaming has made it a much-loved title among gamers for over two decades..
Newer video games, such as Counter Strike Source and Counter Strike Global Offensive, feature updated graphics and new gameplay elements. Despite the passage of time, a core group of players still enjoy Counter Strike 1.6. These players appreciate the game's straightforwardness and its place in gaming history.
CS 1.6 Free is a timeless first-person shooter game. It is worth checking out, regardless of whether you are a long-time fan of the series or a newcomer.


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Top 10 Best Working Torrent Sites [July, 2020 Updated
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The second wave of registration Mop-up for Rapid Response Register (RRR) is scheduled to commence in Kogi state Monday 7th, March 2022 and will last for two weeks.
This was made known by the Kogi Commissioner for Finance, Budget and Economic Planning, Hon. Asiwaju Asiru Idris in a press release made available to newsmen in Lokoja.
According to the release, the registration he said which is online will hit the airwave on Monday morning, adding that the codes for individual urban and semi-urban wards and communities approved by NASSCO and the Federal Ministry of Humanitarian, Disaster Management and Social Development have been distributed to respective Local government SOCU Desk officers and CDOs for distribution and sensitization.
Hon. Asiwaju further disclosed that the USSD code of 969community code# is meant for each community, ward and local government selected. The registration process is through dual means of SMS and Call using the codes.
The release further emphasised that Kogites are advised to quickly obtain the respective community codes of their residence from their Local Government SOCU Desk officers and CDOs for immediate registration through MTN, Airtel, and Etisalat network providers.
He stressed that a successful applicant is expected to obtain an ID immediately after registration and ensure the ID is kept safe for further validation and documentation subsequently for final payment of Covid-19 Cash Transfer on monthly basis.
As contained in the statement, the Kogi State government urged all Kogites to log on with their respective community codes to ensure massive registration to maximize the benefits of opportunity of President Muhammadu Buhari and Governor Yahaya Bello's administration.
You would recall that the World Bank in collaboration with the Federal Government deployed a satellite imagery that captured some urban and semi-urban wards and communities early this for RRR implementation to mitigate the negative impact of the Covid-19 pandemic on people's income which has made life more difficult. It's in a bid to ease the hardship that cash-transfer response strategy was employed to rapidly capture people for cash transfer benefits


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Photo by Kanchanara on Unsplash
Many people who invest in cryptocurrency ask; how much will Bitcoin be in the next five years? Will it rise above $100K or remain as it is now? Ark Invest CEO Cathie Wood seems to have an answer to that question. During the SALT Conference, she predicted that the price of a bitcoin would reach as high as $500,000 in the next five years. However, she also said that her firm now has more confidence in Ethereum than ever, which has increased in value by 350% in 2021.


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LINCOLN PARK — The Cubs insist they ain't afraid of no goats, and in backing them Chicago's scrappiest hot-dog stand ain't afraid of no Cleveland Indians' voodoo god neither.
In its first message on the World Series between the Cubs and Indians, the Wiener's Circle posted a simple, rhyming statement on its marquee sign Wednesday: "F--- You Jobu." Only the only letter it left out was "u."
The sign refers to the idol worshipped by the fictional baseball slugger Pedro Cerrano in the 1989 "Major League" movie.
Those movies feature a fictional bunch of Cleveland Indians, leading actual players on the team this year to adopt Jobu as an inspirational talisman of sorts. Current players Mike Napoli and Jason Kipnis set up a shrine to Jobu in an empty locker between them.
In dialogue from the movie, Cerrano explains how he calls on Jobu to get him out of a slump: "Bats, they are sick. I cannot hit curveball. Straightball I hit it very much. Curveball, bats are afraid. I ask Jobu to come, take fear from bats. I offer him cigar, rum. He will come."
When a God-fearing teammate suggests he try praying to Jesus instead, Cerrano says, "Jesus, I like Him very much, but he no help with curveball."
The Wiener's Circle, 2622 N. Clark St., known for its abrasively caustic way with customers, especially in the late-night, post-bar hours, moved on to the World Series after taking one last shot over the weekend at the Los Angeles Dodgers, vanquished by the Cubs in the National League Championship. Addressing Justin Turner, the Dodgers' redheaded Wildling of a third baseman, the dog stand posted the message: "Justin Turner is a 'Game of Thrones' extra."
The dog stand also allowed that Cub bullpen catcher Chad Noble had won its heart by wearing a hot-dog Speedo during the Cubs' clubhouse celebration after clinching a spot in the World Series Saturday night, even coming out on the field in it, complete with protective goggles for the eyes.
Chad Noble, the @Cubs bullpen catcher is wearing a Hot Dog speedo! He is our true hero and MVP tonight! 👙🌭 @PeteRose_14 pic.twitter.com/p2mSYnVPAY
— The Wiener's Circle (@TheWienerCircle) October 23, 2016
The Cubs renew the World Series with the second game in Cleveland Wednesday night after losing the opener of the best-of-seven series Tuesday. The series comes to Wrigley Field for the middle three games on Friday.
For more neighborhood news, listen to DNAinfo Radio here.


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Here you can be informed about
ATTSU Latest News
ATTSU installs a steam boiler of 8,000 kg / h in one of the most advanced and efficient laundries in Europe.
The system incorporates an innovative system of energy recovery capable to increase 18% of the total power savings against any conventional system.
The system consists of a closed cycle where 100% of the energy produced in the boiler is used.
The power installed at the plant is 6,100 kW and is fed with Natural Gas.


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Email: [email protected]
What do you love about what you do at NH?
I love interacting with the middle schoolers whether it's playing games, baking cookies or even spending a weekend with them at camp. I have also really enjoyed preparing lessons for Sunday's message.
What year did you join staff?
January 2022
How did you come to know Jesus?
I first heard the gospel message at an early age at camp. He talked about how I was born a sinner and the only way that I could get into heaven was to trust that Jesus could take away that sin. It wasn't until I asked my parents about what it all meant that I truly put my faith in Jesus.
What's your favorite Bible verse?
Ephesians 3:20 – Now to him who is able to do far more abundantly than all that we ask or think, according to the power at work within us.
What is your best childhood memory?
My best childhood memory is of my brothers and I at the sand dunes in Alamosa, Colorado. We would go sledding down the hills, play in the river and play football. They are a lot like Sleeping Bear Dunes here in Michigan, but the sand dunes are a lot bigger and surrounded by the Rockies.
What is the best advice anyone has ever given you?
The best advice that I have ever heard was from some friends of mine from Bible college. We were having a discussion about what the purpose of life was. We all agreed that it was to glorify God and enjoy him forever.


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Estimated reading time: 3 minutes
Why do cats purr, have a rough tongue, and have 11 more questions about our kitties?
Why do cats like to smell valerian root?
There is no exact explanation for why cats love to smell valerian root. But all theories have to do with the proximity of its scent to feline pheromones and feline sex gland secretions.
Why do kitties like boxes?
Cats like not only boxes but all dark and maximally protected places. This is because cats are evolutionarily non-human creatures (not so much like humans) (not all kitties and not all humans). They prefer to live in secluded places, away from congeners, and with a clear territory. Therefore, every cat in the house must have a place where it can hide and be alone.
Why do cats sleep a lot?
A cat is a nocturnal predator. Physiologically, these animals are active at night or closer to dawn and sleep during the day. So it turns out that the pet sleeps during the day, and at night, disturbing the owner, quickly gets his portion of food and rests again, "having completed the hunt.
Why do cats sleep at their owner's feet?
Kitties sleep where they feel safe and still have room to react quickly. The proximity and warmth of the owner are comfort factors.
Why are kitties afraid of water?
There are no large bodies of water in the habitat of feral cats – they do not need them. Therefore, this is an unfamiliar environment for animals. And, thanks to living close to humans, many pets are very fond of water procedures.
Why are kitties purring?
Scientists still don't know how cats do it and what organs they use. But the sound of purring is not always a sign of good mood and affection; it often occurs in stressful situations and painful conditions.
And, only domestic kitties purr; no such peculiarity has been revealed in wild kitties. Maybe purring is a way to communicate with people.
Why do cats leave home to die?
When a cat is in pain and discomfort, it always looks for dark, secluded places. This is how the myth of them leaving home before they die was born. When a cat is in pain, it hides somewhere.


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Air ducts are a critical part of your HVAC system that are often neglected. Let Bob's Repair handle your air duct cleaning in Henderson. Connected to your HVAC system, air ducts can circulate dust and other pollutants throughout your home. The air quality in your house depends on the cleanliness of circulating air. Regular air duct cleaning is a critical part of HVAC system maintenance.
Indications That Your Air Ducts Need Cleaning in Henderson
- Dust build-up in vents and registers
- Increased allergies or respiratory problems
- Mold presence in or around your HVAC system
- Unexplained or musty smells
- Excessive dust on home surfaces
Advantages of Air Duct Cleaning in Henderson
Cleaning your air ducts enhances your air conditioner's efficiency and guarantees that the air you breathe indoors is clean and healthy. A clean air filter also contributes to the efficient running of your AC unit.
Better Indoor Air Quality
Getting your air ducts cleaned in Henderson can improve your family's health. The cleaning process reduces the dust that would otherwise circulate throughout your home, affecting everything in it. AC duct cleaning decreases the amount of interior cleaning and dusting required to maintain a hygienic environment.
Increased HVAC System Efficiency
Ductwork and air vents with substantial dust, grime, pet hair, and dander build-up can restrict air flow from the furnace and air conditioner, forcing your system to work harder to regulate your home's temperature. A professional cleaning keeps the system running efficiently, potentially saving you money on energy bills.
Prolonged HVAC System Lifespan
Regular air duct cleaning in Henderson can extend the life of your HVAC system.
Decreased Allergens and Irritants
Dust isn't the only issue in your air ducts. Many harmful contaminants and microorganisms like pet dander, bacteria, pollen, mildew, mold spores, and other toxins are found in your duct system, which can also produce unpleasant smells. Regular air duct cleaning by Bob's Repair's certified technicians ensures a healthier lifestyle and reduces allergy symptoms.
Removal of Unpleasant Odors
Harmful bacteria can degrade indoor air quality, with the airflow through your vents often being the culprit. Also, pets, household cleaners, cigarette smoke, mold, and stale food smells contribute to the odors flowing through the air ducts. A thorough duct system cleaning from Bob's Repair can reduce or eliminate these odors, leaving your home smelling fresh.
Our Thorough Air Duct Cleaning Process in Henderson
Our expert technicians provide comprehensive ductwork cleaning, using the latest technology and equipment to clean your ducts and remove built-up debris and pollutants. We aim to remove as much debris as possible. We use portable systems, carried room to room by our technicians, who insert a hose in each vent to clean the ductwork.
Why Bob's Repair is Your Best Choice for Air Duct Cleaning Services in Henderson, NV
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Our skilled technicians can handle all your needs, from air ducts cleaning to dryer vent cleaning in the Henderson area. We can also handle your air conditioning repairs or HVAC systems replacement. Leave your duct cleaning to us and we promise to do a thorough job, ensuring clean air flows through your system, potentially lowering your energy bills.
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"Daniel Johnson and his team were honest, professional, knowledgeable, and courteous. They did an excellent job cleaning our air ducts. We'll definitely hire them again!"
"Bob's Repair team are highly knowledgeable and professional. They explained every part of the service in detail. I had 3 estimates before I chose Bob's Repair in Henderson and I felt confident and comfortable with my choice. They even had the city inspect the work to ensure it was done up to code. Very satisfied with my choice. Thank you, Ready for Summer!"
Contact Us for Your Air Duct Cleaning Needs in Henderson, NV
Escape the dust and allergens in your home. Let our HVAC systems help. With numerous positive customer testimonials, why look elsewhere? Our technicians are knowledgeable and experienced, equipped with the latest tools to provide prompt and efficient air duct cleaning service. We work with you to find the right HVAC solution that meets your specific needs and budget. We offer a variety of brands and models to choose from. Trust Bob's Repair to provide the best service for all your air duct cleaning needs with high-quality products. We ensure proper installation and customer satisfaction. Call for an appointment and get a free estimate with no hidden fees. Financing options are available. Call (702) 381-5080 for all your air duct cleaning needs in Henderson, NV.


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Making a donation to the Heritage Foundation is an excellent way to contribute to its mission of promoting free enterprise, limited government, individual freedom, traditional American values and a strong nation. The Heritage Foundation is a 501 (c) () non-profit organization that works to facilitate the successful placement of leftover wild horses and donkeys in the United States through innovative programs, events and education. Donations to the Heritage Foundation are tax deductible and 82 cents of every dollar donated goes directly to work in the community. The Heritage Foundation also guarantees that donors' names and addresses will not be shared with third parties without permission. Donors can also set up recurring donations to be processed on a monthly basis for the amount specified.
The Heritage Foundation uses donor information to understand their interests in its mission and to keep them updated on the organization's plans and activities. Heritage Action's lobbyists and grassroots activists are also working hard to ensure that The Heritage Foundation's policies reach their goals. By donating to the Heritage Foundation, you can help support these efforts and make sure that your donation is being used effectively. If you would like to learn more about how your donations are being used by the Heritage Foundation, you can contact them directly or visit their website. They will be able to provide you with more information about their programs and how your donations are making a difference.


text: Hello everyone, Since LibreOffice 6.0, the macOS requirements have been bumped to macOS 10.9 (aka Mavericks) [1]. However, on the website [2], this is written macOS 10.9 (Mountain Lion). Mountain Lion was version 10.8. 10.9 is Mavericks. Please correct to Mavericks instead. On the French website, this is still 10.8 (other pieces of info are outdated as well). Also, I hereby ask you to get accesses to the Silverstripe French website. Sometimes, Sophie and JB Faure have too much work and being able to fix issues like this would avoid them unneeded burden. Regards, (Ps.: I'm not subscribed to the list, please put me in cc). [1] https://wiki.documentfoundation.org/ReleaseNotes/6.0#macOS [2] https://www.libreoffice.org/get-help/system-requirements/ [3] https://fr.libreoffice.org/get-help/system-requirements/ -- William Gathoye <email@example.com> -- To unsubscribe e-mail to: firstname.lastname@example.com Problems? https://www.libreoffice.org/get-help/mailing-lists/how-to-unsubscribe/ Posting guidelines + more: https://wiki.documentfoundation.org/Netiquette List archive: https://listarchives.libreoffice.org/global/website/ Privacy Policy: https://www.documentfoundation.org/privacy


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Tragedy of the Bush Administration
107 RepliesJump to last post
Moving 300,000 troops with equipment is not that easy. After 91 (desert storm revolution) everyone suspected when we went in the people would help. Well this sorta happened, but terrorists from Syria, Afganistan and Iran joined the fight. Then for $2 a kid would plant a bomb.
Maybe 300,000 troops would have been for the best, but for sure we would have been an "occupier".
Hey Joe thanks for helping me with the spelling.
[quote=SonnyClips]You are never free...if you are a Republican...[/quote]
Clipper...if you use that as your sig line, I'll have to charge royalties for copyright infringement...
BTW...I am an independent...both in my line of work and my politics, but I'll have to confess to some republican leanings...
...and I still feel pretty free...
You are not "independent". Independent is actually a party.
You are not free unless you are unaffiliated.
[quote=tjc45]Sixers lost to the Bulls last night. They showed a small glimmer of life and closed the 30 point gap to about 20.[/quote]
How did AI play?
The Knicks RAWK!
You should all listen to Michael Savage, he has been right on, after 9/11 we should have given the Muslims 48 hours to kill all of their radical extremist leaders,(They know who they are) if they didn't comply, we start nuking cities why put our troops in arms way?
How many cities would we have to nuke before they started cutting off heads of extremist ? ONE..............
America needs to get back taking care of their own, if the terrorist kill one American we should kill 100,000 of theirs ..........not with troops, but with nukes.................better them, than our home land.
We are at WAR, UNFORTUNATELY 50% of Americans are our worst enemies, called LIBERALS.............Maybe we need a civil war at home first, or we could divide the country and let the Liberals be taken over by the Terriost, they could offer peace and love while their heads are being cut off.........we don't need a military do we?
Player…you're an idiot. Now get back to watching the 700 club, your leader needs more lemmings.
More "postive" developments on the Iraq front.
http://www.newsday.com/news/nationworld/world/la-022206iraq_ lat,0,403842.story?coll=ny-leadworldnews-headlines
Yeah, civil war (as was predicted by many experts) may be an outcome of our meddling. Love to see where this ends up.
Three cheers for Bush.


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Draft of NAB amendment ordinance sent to President
Justice (retd) Javed Iqbal to keep serving post of NAB chairman till a new chairman is appointed
ISLAMABAD (Dunya News) – After the approval of Prime Minister (PM) Imran Khan, the draft of National Accountability Bureau (NAB) amendment ordinance has been sent to the President.
According to the reports, the NAB Amendment Ordinance 2021 has been prepared. The prepared ordinance has been sent to the President Dr Arif Alvi.
According to the proposed ordinance, the President has the power to reappoint the NAB chairman on completion of his four-year term. Prime Minister (PM) Imran Khan and Opposition Leader in National Assembly Shehbaz Sharif will be consulted for the reappointment of the NAB Chairman. Justice (retd) Javed Iqbal to keep serving post of NAB chairman till a new chairman is appointed.
Prime Minister Imran Khan on Tuesday approved draft NAB amendment ordinance.
According to sources, a meeting of the legal team was held under the chairmanship of PM Imran Khan. Law Minister Farogh Naseem, Attorney General Khalid Javed Khan, Federal Minister for Information and Broadcasting Fawad Chaudhry, Federal Minister for Planning Asad Umar and Advisor on Parliamentary Affairs Babar Awan attended the meeting.
The prime minister has approved the draft NAB amendment Ordinance and the summary of which will be approved by the Cabinet through circulation. The proposed ordinance includes a provision to retain the current NAB chairman until a new chairman is appointed.
The proposed draft ordinance also includes a provision to consult the Leader of the Opposition on the appointment of NAB Chairman.
Earlier, briefing after the meeting of the federal cabinet, Federal Minister for Information Fawad Chaudhry said that a draft ordinance had been prepared by the government for extension of NAB chairman's tenure but there was no discussion in the cabinet on the matter today adding that opposition should change leader of the opposition in the National Assembly for consultation on the issue.
Fawad Chaudhry said that modern technology would be used in the new census in the country.
The minister said that the cabinet had also approved that next census will be held as per de-jure rules and regulations. He said rules and procedure for next census will be presented before the Council of Common Interest for approval. He said modern technology will be used in the next census, while all other organizations like NADRA will cooperate for this purpose. He said delimitation of constituencies will be undertaken in the final phase of the census.


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Welcome to our store
You may return most new, unopened items within 30 days of delivery for a full refund. We'll also pay the return shipping costs if the return is a result of our error (you received an incorrect or defective item, etc.).
You should expect to receive your refund within four weeks of giving your package to the return shipper, however, in many cases you will receive a refund more quickly. This time period includes the transit time for us to receive your return from the shipper (5 to 10 business days), the time it takes us to process your return once we receive it (3 to 5 business days), and the time it takes your bank to process our refund request (5 to 10 business days).
If you need to return an item, simply login to your account, view the order using the "Complete Orders" link under the My Account menu and click the Return Item(s) button. We'll notify you via e-mail of your refund once we've received and processed the returned item.
Blush yoga mat
Cork Yoga Block
20 pack of Incense
Our best selling yoga mat, used and recommended by yoga teachers all around the world. This yoga mat is different from the printed yoga mats in that the top of the yoga mat is non slip, with super grip technology that reduces slipping. It is made with natural rubber, and 100% PVC Plastic free.
Read the Blog about why our yoga mats are PVC Free.
Easy to wipe clean with cushion support, this yoga mat is made for every type of practice. Our beautiful sun design has been laser etched onto the pink yoga mat.
Read about our Yoga Mats Here.
Free from latex, silicone and phthalates.
Find out how to care and clean your yoga mat Here.
• Material: 100% Natural Rubber and Polyurethane
• Dimension: 1850 mm in length by 680 mm width.
• Weight: Approximately 2.5 kilos.
• Thickness: 5 mm thick
• Super grip, non-slip, cushion support.
• Perfect for all types of yoga, hot yoga, ashtanga, vinyasa, pilates.
• For Beginner to Advanced Yogis.
• Free Eco printed yoga strap valued $24.99.
To Clean
• Simply wipe down with water.
• DO NOT use mat sprays, oils, detergents or essential oils when cleaning this product.
• Made from 100% natural cork, used to unlock new stretches and positions helping your body with stability and support in your practise.
• Dimensions: 23cm in length by 14cm wide by 7.6cm in depth
Yoga Incense Mixed Pack
A beautiful pack of 20 Incense sticks with natural oils - 10 x invigorating Jasmine with Frangipani + 10 x calming Frankincense with Cedar wood.
Please leave us a note if you would like complimentary Gift wrapping.
Returns Policy
Local Threads is committed to your 100% satisfaction and aims to always provide you with the latest fashion that are of the highest quality! If your purchase is not delivered as described or if it does not quite fit, simply return the item/s within 7 days of receiving your order for a hassle-free refund. Exclusions include all jewellery, swimwear, underwear and non-returnable items unless deemed faulty. To best support our local brands, returns for change of mind decisions and sale items are not permitted.For more information with specific instructions, please visit: www.localthreads.com.au/pages/return-policy
Local Threads is a proudly Australian company and only offer local shipping.
Product | SKU | Rating | Description | Collection | Availability | Product Type | Other Details |


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February 22, 20244It's 90 seconds to midnight: Can Catholics stop the tick tock of the Doomsday Clock?
February 21, 20244Can small Christian communities help heal a 'Eucharistic famine'? This Maryknoll priest thinks so
February 21, 20244Friar who said Ash Wednesday Mass for Roumie, Wahlberg shares how to meet God in Lent's 'desert'
February 21, 20244Guadalupe: Madre de la Humanidad, una película que llega a las salas de cine para mover corazones
Focus on Faith. February 23, 2023 Abrahamic Family House opens in Abu Dhabi as a fruit of Pope Francis visit in 2019 By OSV News Abrahamic Family House (AFH) will be opened to the public March 1.


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This topic contains 4 replies, has 2 voices. Last updated by Raam Dev 4 years, 11 months ago.
Topic Author | Topic |
Posted: Tuesday Feb 7th, 2012 at 2:02 am #4270 | |
Hello, I have only one level of access (Level 1) for which I want to charge a monthly fee or discounted quarterly fee or discounted yearly fee; say $4.95/mo or $12.95/quarter or $49.95/yr. On the Paypal site they have a nifty "Subscribe button" with a drop down menu I can configure to choose $4.95/monthly or $49.95/yearly. Ideally, I would like a drop down menu with all three options, but I will make use of the two option Paypal "Subscribe" button if I have to. Is there any way to configure the Pro Forms Shortcode to give a Subscriber the three payment options or do I have to generate three shortcodes? I really like the Paypal "Subscribe" button but it only has the monthly and yearly option. Is there any way of adding a the quarterly option to the Paypal button? What are my options? Any suggestions on how to get the Pro Forms Shortcode to be an all in one drop down menu subscribe form? Thanks for your time. Bill |


text: Molecular diagnostics are increasingly performed routinely in the diagnosis and management of individuals with melanoma due to the development of novel therapies that target specific genetic mutations. The results of this study demonstrate the cost-effectiveness and feasibility of a custom-designed targeted NGS panel, and suggest the implementation of targeted NGS into daily routine practice. Introduction Malignant melanoma is the most aggressive form of skin cancer, with a poor prognosis for patients with metastatic disease. Melanomas are currently classified based on clinical and histologic characteristics of the primary tumors; in addition, it has been described that distinct patterns of genetic alterations contribute to the development GNE-493 of the different subtypes of primary melanoma. It is well known that superficial spreading melanoma (SSM) and nodular melanoma (NM) are associated with or mutations; acral lentiginous melanoma (ALM), lentigo maligna (LM), and mucosal melanoma are more often associated with mutations; and ocular melanomas are not associated with these common oncogenes, but with or modifications1 rather, 2. A recently available integrative evaluation of cutaneous melanoma through the Tumor Genome Atlas (TCGA) has generated a fresh genomic classification into four subtypes, predicated on the recognition of the very most common mutated genes [BRAF, RAS, NF1 and triple-wild type (wt) subtypes]3. The advancements on melanoma molecular pathogenesis possess opened a fresh insight for the administration of advanced melanoma because of the advancement of novel therapies that focus on causative genetic occasions, and improve disease free of charge survival and general survival4. The selective BRAF kinase inhibitors (Vemurafenib and dabrafenib) work in mutant melanoma; MEK inhibitors (trametinib and cobimetinib) display effectiveness against both mutations could possibly be recognized at an allele rate of recurrence GNE-493 only 0.05% with an interest rate of false reads of 0.1%. Modifying the level of sensitivity to your error-rate Consequently, the limit of recognition was 0.5% (Figure?S2). Shape 1 Quality metrics for 25 operates including mean insurance coverage, total reads, reads on uniformity and focus on. Desk 1 Sequencing outcomes of serially diluted DNA isolated from two adenocarcinoma cell lines (HT-29 con Caco-2) with known variations in and genes. Mutations recognized by Next-generation sequencing in melanoma Mutation prevalence Sequencing determined normally 56.6 total variants and 8.9 exonic variants per test, which were subsequently filtered to be able to exclude variants without impact on protein function. After filtering, a total of 135 different pathogenic variants were finally reported in all the samples (Table?S1). In the entire cohort, 94% (94/100) had at least one pathogenic variant, and 51% (51/100) had 3. Without considering polymorphisms, 85% (85/100) of the melanomas had at least one somatic mutation. The most prevalent mutated genes were (50%; 50/100), (15%; 15/100), (14%; 14/100), (13%; 13/100), and (12%; 12/100). All the mutated genes are represented in Fig.?2. Regarding gene, the most frequent mutation was p.V600E (80%; 40/50), followed by p.V600K (10%; 5/50), p.K601E (4%; 2/50), p.L597R (2%; 1/50), p.L584F (2%; 1/50), and p.G464R (2%; 1/50). The most frequent affected codon in was Q61 (87,6%; 14/16), followed by G12 (6,3%; 1/16) y E62 (6,3%; 1/16). oncogene mutations were identified in 3% (3/100), and the most prevalent mutation was p.Q61R GNE-493 (75% ; 2/3); mutations were detected in 5% (5/100) of the samples, and two of them showed the hotspot mutation p.L576P. In regard to and mutations were present in 9% (9/100) of the melanomas, with a recurrent point mutation in two of the samples (p.F278L). mutations were not identified in our cohort. mutations were detected in 8% (8/100) of the melanomas; and nonsense mutations were the most prevalent alteration [62.5% (5/8)], including one recurrent mutation present in two samples (p.R1362*). The overall prevalence of variations in and genes, was 28% (28/100) and 21% (21/100), with a total of 31 and 27 different variants dispersed throughout the entire gene, respectively. After filtering out, the prevalence of pathogenic variants was 14% (14/100) for gene and 13% (13/100) for gene. variants were also identified in 15% (15/100) of the samples, and 80% (12/15) of them were predicted as pathogenic. Hotspot mutations were detected in (p.P29S and p.P69L) and (p.D193Y, p.P209L, and p.R264C) in 8% and 6% of the samples, respectively. None of the melanomas harbored the hotspot activating mutation p.S722F in pathogenic variant (p.P814S). Figure 2 Frequency of somatic gene mutations. Each column represents 1 sample and GNE-493 each row represents 1 gene. The column on the left indicates the percentage of samples with specific gene mutation. Although paired tumor-normal samples were not collected, NES melanoma related polymorphisms were analyzed. polymorphisms were detected in 66% (66/100) of the patients; 4% (4/100) showed polymorphisms.


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Raiders grant QB permission to seek deal
February 3rd, 2023The Jets could potentially trade for Las Vegas Raiders QB Derek Carr. Here's the latest buzz…
Feb. 3, 5:40 p.m.
The Raiders have reportedly granted Derek Carr permission to speak with other teams interested in trading for him, according to ESPN's Adam Schefter.
The interested team must also agree to compensate the Raiders. This is the same arrangement the Houston Texans offered quarterback Deshaun Watson when they were looking to shop him last offseason.
Jan. 29, 7:31 p.m.
A new report suggests that the Jets will search for a veteran quarterback, and that will star with the Raiders' Derek Carr, Packers' Aaron Rodgers among others, according to CBS Sports' Jonathan Jones and NFL Network's Ian Rapoport.
"While the Jets will certainly take a long look at potentially trading for Rodgers, he's not the only veteran quarterback the team is evaluating," Jones wrote Sunday for CBS Sports. "According to sources, the Jets will be looking closely at Rodgers, (San Francisco 49ers quarterback) Jimmy Garoppolo and Derek Carr. They won't limit their search to just those three quarterbacks — and sources stress it's still early in the process — but that's where the focus will begin."
Jan. 21, 1:00 p.m.
Derek Carr is expected to be deal from the Las Vegas Raiders "earlier rather than later."
While speaking on ESPN's Postseason NFL Countdown, Adam Schefter said Carr is expected to be traded at some point this offseason.
"The entire NFC South is expected to be in the market for a new quarterback," Schefter said. "The Jets, the Commanders, the Colts, the Texans. There are so many teams that need quarterbacks, which elevates the value of Carr."
Disclaimer/Note: TGM Radio's latest news posts are a collection of curated and aggregated, fresh content from the best news sources across the globe.
Tags: sports


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The estimated jackpot for this historic draw for the most well known game in America is $293 million. To win the grand prize, the ticket need to match all 5 numbers and the red Powerball number. Powerball players have spent an estimated $2.6 billion on tickets since the final jackpot was claimed in November. The Powerball lottery jackpot for the Monday, Aug. 23, 2021, drawing is worth an estimated $293 million. "Players have let us know they want to play for larger jackpots and cash prizes, and we want Powerball to provide on their expectations" Reardon stated.
In the 2020 fiscal year, the Lottery provided almost $1.18 billion for Michigan's public schools, its sixth record contribution in a row. Because it began in 1972, the Lottery has contributed a lot more than $24.five billion to support public education in Michigan. For extra facts, stick to the Michigan Lottery onFacebook,Instagram,Twitterand on-line atMichiganLottery.com. The Palmetto Cash 5 ticket matched all five numbers drawn on Friday, Aug. 20, for a prize of $300,000. The ticket holder "Powered-Up" for an further $1, to see the $100,000 prime prize multiplied to $300,000. "I had it scanned at a convenience retailer and the clerk indicated that I had to go to the Lottery to claim the prize," Thomas said.
With no jackpot winner, it moves to No. eight in the jackpot rankings. In addition to the winning jackpot tickets, lottery officials stated eight tickets that won $two million have been sold in seven states, and 73 that netted $1 million had been sold in 23 states. The Power Play® add-on function will also be available for an added $1 per play to multiply non-jackpot prizes. Thomas Yi, 23, claimed a $235.four 파워볼 게임 million jackpot prize from the POWERBALL®drawing held on March 27, 2020 at Florida Lottery Headquarters in Tallahassee. Officials reported that Morgan purchased the winning Swift Pick ticket from the Publix Liquor Store at Beach Boulevard in Jacksonville. The retailer will obtain a $1,000 bonus commission for selling the winning ticket.
"The odds of winning $40,000 playing Mega Millions are 1 in 931,001, and the odds of winning $3 million are about 1 in 13 million," the South Carolina Education Lottery stated in a statement. The premise of the game has not changed, you still need to have to match 5 numbers between 1 and 69, and the Powerball which characteristics a variety of numbers among 1 and 26. The Powerplay feature will nevertheless be offered for all drawings for just a dollar if you want to opt-in on that. Ticket sales from a third weekly Powerball drawing and Double Play® will contribute to funding public programs and solutions in each and every jurisdiction exactly where the Powerball® game is sold. Michigan Lottery's official on line internet site with 24 hour immediate games on line.
Besides the jackpot win, somebody who bought a $3 Power Play ticket at the Charlotte Bistro at Charlotte Douglas International Airport in Charlotte won $100,000 in the drawing. Lottery officials stated North Carolina has now had 5 Powerball jackpot winners, and this is the seventh time someone in North Carolina has won either a Powerball or a Mega Millions jackpot. Officials stated the winner has 180 days to claim the prize. Officials with the North Carolina Education Lottery said the winner has two options for how they can obtain their winnings.
A single who lived in Missouri and the other person lived in Arizona. The winning ticket was obtain at the Publix positioned at North Nebraska Avenue in Lutz. Publix will obtain a $95,000 commission for promoting the winning ticket. Lottery officials mentioned the ticket matched all 5 white balls, but not the Powerball number. The Rolling Cash 5 jackpot for the subsequent drawing is $100,000 for hitting all five numbers and the odds of winning are 1-in-575,757.


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You have a software development project with outlined scope
Software product development service covers the process of creating ready-to-use software according to your requirements. It's designed for projects where your budget, timeline, and deliverables are clearly defined – MVP development or any software engineering tasks with a fixed scope of work. If the backlog is not fully defined, we carry out the discovery phase to prevent challenges in project scoping.
In a fixed-price model of software product development, the project cost and schedule are agreed upon before any work begins. A cross-functional team of IT experts ensures your project meets all milestones on time, so you can feel confident about the end product reflecting your business needs.
You have a software development project with outlined scope
You clearly defined and documented product requirements
You want to minimize risks and hand over control to the team
You have a fixed budget for your project
You have a tight deadline or a specific release date
Software implementation project with a clearly defined timeline
Companies with a detailed & documented vision of how the product should work
Projects that need to be delivered according to a signed-off budget
Teams that prefer to complete project planning before starting development
A fixed-bid contract lets you predict your project cost more accurately. This type of contact simplifies your budgeting, as the price is set at the beginning of a project. However, it's vital to keep in mind that requirements may change during the course of development. In this case, we initiate the change request process and evaluate its impact on the project budget and timeline wise.
Whether you want to build an MVP or develop several specific features, you know exactly what will be delivered. You give us a concept and business requirements, and we deliver features you need – as simple as that! If you meet challenges in product scoping that seem impossible to overcome, we conduct a short-term discovery phase to remove all uncertainties.
Since product requirements are well-documented from the onset, projects tend to move along quickly and without a hitch. Our team adheres to the schedule so that your project stays on track from start to finish. We test every feature and ensure it's delivered with highest level of quality fully meets user's needs and customer expectations.
In a project where all details are specified beforehand, you need minimal supervision. At the same time, a project manager keeps stakeholders in the loop through demo sessions and status meetings. This way, we can communicate progress and make sure everyone is on the same page.
At BV, you'll find a partner who cares about your success as much as you do. Our team becomes an extension of yours, working tirelessly to bring your vision to life. We don't just write code – we think ahead, help to move faster, and prevent complications. We go above and beyond to ensure our clients are happy with the final results of their projects. That's why our customer satisfaction score reaches 95% with an average engagement of 5+ years.
We've been building up tech expertise since 2009. By following industry standards, we help businesses get the most out of software development services. Although we've earned the Microsoft Partnership, our expertise goes far beyond the Microsoft stack and covers diverse cutting-edge technologies. So, when you work with us, you can be confident that you are working with some of the best minds in the industry and natural problem-solvers. Our drive to share and multiply knowledge guides everything we do and lets us deliver top-notch solutions.
Our rigorous hiring process adheres to extremely high recruitment standards without any compromises. We evaluate dozens of engineers to fill senior positions, while many talented junior developers come from our Academy program with a 5% acceptance rate. Most of our engineers major or double major in math and computer science, and our management team has in-depth industry knowledge and experience. The pursuit of excellence earned us a reputation as a reliable employer that keeps retention at 87%, with 1/5 of employees engaged for 7+ years.
We are passionate about what we do and take pride in our work. Our corporate culture is built around open communication, creative thinking, and collaboration. Day by day we maintain a thriving environment where everyone can openly share concerns, give regular updates, and exchange constructive feedback. As Ukrainians, we share a European mindset and sync with our clients' values at all times.


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Software-as-a-service companies are known for their explosive revenue growth. Given the ongoing migration from on-premise to the cloud, these revenue trends are sustainable. Below are some of the best SaaS stocks to buy and hold.
According to Orlando Bravo, one of the most successful technology investors, software is the best business in the world. The industry has higher growth rates, recurring revenues and best-in-class gross margins. Considering the success of Thoma Bravo, it is worth paying closer attention to the SaaS industry to unearth long-term winners.
Although SaaS stocks typically exhibit above-market growth, the space is highly competitive. Indeed, only a few companies manage to build economic moats around their business and increase barriers to entry. Thus, this SaaS stocks to buy and hold list will focus on the best-of-breed software companies.
The following businesses have become platform companies that thousands of large enterprises rely on. Today, they are the market leaders in their segment and are still achieving remarkable growth. Given their dominance, these stocks will soar over the next five years as cloud migration continues.
ServiceNow (NOW)
ServiceNow (NYSE:NOW) is one of the most critical enterprise software companies. Its Now platform integrates varying data systems and siloed software to automate workflows and boost productivity. According to Gartner, ServiceNow has been a leader in ITSM (IT Service Management) for nine consecutive years.
Due to the productivity and efficiency gains from its software, customer relationships have expanded. Q3 2023 earnings revealed that customers with over $1 million in annual contract value grew from 1,258 in Q3 2021 to 1,789 in Q3 2023. What's more, the average ACV of customers with at least $1 million in ACV grew from $3.6 million to $4.4 million over the same period.
Based on the growth above, it's clear that customers see benefits and continue to increase spending. Today, ServiceNow is leveraging AI to improve the Now Platform. This will enhance the stickiness of the Now Platform, making ServiceNow one of the top SaaS stocks to buy and hold. Features like performance analytics, predictive intelligence and virtual agents will improve its value proposition to customers.
In terms of growth, ServiceNow is still shining. It has consistently achieved over 20% revenue growth. Moreover, profitability is accelerating, with the firm reporting 30% free cash flow margins. AI presents opportunities to enhance the Now Platform and the stock should be a mainstay in your portfolio.
Workday (WDAY)
This cloud-only human capital management software provider has led innovation in the space since its launch in 2005. Today, over 10,000 organizations use Workday (NASDAQ:WDAY) for finances and human resources. Remarkably, over 50% of the Fortune 500 are customers.
Since its launch, Workday has disrupted traditional ERP providers such as SAP SE (NYSE:SAP) and Oracle (NYSE:ORCL), taking market share. As a result, the company has achieved an impressive 21% compounded annual revenue growth revenue growth over the last five years. According to Gartner Research, it's the leading cloud ERP provider worldwide, with a 21% market share.
The company sees growth opportunities in introducing more solutions. After starting in human resources, it introduced financial and spending management solutions to address the needs of chief financial officers. Since 75% to 80% of financial software is still on-premises, a significant growth opportunity exists.
Furthermore, Workday is targeting growth in the underpenetrated medium enterprises space. In its September 2023 investor presentation, management stated they expect over 50% of new ACV from the segment. They also plan to target medium-sized enterprises in the U.K., Germany, France, Canada and Australia.
For the long term, management sees a $58 billion market opportunity in HCM and $84 billion in financial services. As they pursue this market, they expect to increase core customers from 5,000 to over 40,000. Based on these projections, they see 17% to 19% annual subscription revenue growth.
Lastly, management sees a huge white space opportunity in the top 100 accounts. They forecast over $2 billion in incremental annual recurring revenue. These incremental growth opportunities, an expanding total addressable market and international expansion mean Workday is one of the top SaaS stocks to buy and hold.
Salesforce (CRM)
As a pioneer of the SaaS model, Salesforce (NYSE:CRM) has grown to be one of the largest cloud companies. It offers mission-critical software used in the full sales cycle, from lead generation to customer retention. According to International Data Corporation (IDC), it is the category leader with over 20% market share.
The company has quickly integrated AI into its products, enabling enterprises to offer personalized digital experiences. By leveraging customer interactions, companies are creating customized experiences using Salesforce. For instance, creating personalized email segments with customer-specific information.
AI will be a massive growth opportunity and the company is leading innovation with its Einstein GPT Copilots. During the Q3 fiscal year 2024 earnings call, management disclosed that 17% of the Fortune 100 are using the product.
Secondly, the new data cloud product is gaining significant traction. Furthermore, there are substantial upsell opportunities among its various clouds, which include Sales Cloud, Service Cloud, Marketing Cloud, Commerce Cloud, Slack, Tableau, MuleSoft, among others. In Q3 fiscal year 2024, nine out of ten deals included six or more clouds, highlighting the multi-cloud momentum.
Salesforce continues to deliver improvements, expecting FY2024 non-GAAP operating margins of 30.5%. That's an 800-basis point improvement showing the focus on profitability. The company has also stepped up its share buyback program, returning $10 billion in five quarters.
With Data Cloud, Einstein GPT Copilots and upsell opportunities, CRM remains one of the best SaaS stocks to buy and hold. It trades at 34 times forward earnings, a reasonable valuation for a high-quality cloud stock.
On the date of publication, Charles Munyi did not hold (either directly or indirectly) any positions in the securities mentioned in this article. The opinions expressed in this article are those of the writer, subject to the InvestorPlace.com Publishing Guidelines.


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We are using the contacts tab under projects and noticed that the phone number pulls in without any dashes. Even though this pulls directly from the customer contact, which shows the number formatted correctly, for whatever reason the formatting does not pass through to the project contact tab table. See attached.
We have the information from the project contacts tab pulling to a report and would like to have the phone number formatted correctly. I've tried every format option in report designer that I can think of (or found based on searching the internet) and nothing is working. Does anyone have any suggestions on how to get the correct formatting? I'm assuming having it corrected on the project contacts tab would have to be an Acumatica thing, but surely there is something in report designer I can do.


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Switch to Russian |
Brett Anderson
Brett Lewis Anderson (born 29 September 1967) is an English singer-songwriter, best-known as the lead vocalist of Britpop band Suede. After Suede disbanded in 2003, he briefly fronted The Tears and released three solo albums. Suede reformed in 2010. Albums
Brett Anderson: Suede To Carry On After Reunion GigsDecember 14, 2010 Suede frontman Brett Anderson has said the band are likely to carry on performing following their recent reunion. The group, who split in 2003, have a played a series of one-off shows this year, but until now have remained tight lipped over whether they will continue. Read more
Brett Anderson Announces 2010 UK TourNovember 4, 2009 Brett Anderson has announced details of a brief UK tour for January and February 2010. The former Suede singer will play a trio of shows in London, Manchester and Glasgow in support of his third solo album, 'Slow Attack', released yesterday. Read more
© 2011 Music World. All rights reserved.


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Kelly Stables Net Worth: In the dynamic realm of entertainment, Kelly Stables stands as a testament to versatility and talent. With her diverse acting roles spanning across comedy and drama, Stables has left an indelible mark on both the big and small screens. From her early days in showbiz to her memorable performances, her journey is an inspiring tale of determination and adaptability.
Kelly Stables In-Depth Profile: Full Name, Age, Notable Works, Net Worth, Controversy, Nationality, Career, Occupation
Attribute | Information |
Name | Kelly Stables |
Full Name | Kelly Michelle Stables |
Kelly Stables Date of Birth | January 26, 1978 |
Kelly Stables Birthplace | St. Louis, Missouri, USA |
Kelly Stables Occupation | Actress, Voice Artist |
Kelly Stables Notable Works | "Two and a Half Men," "The Exes," "Superstore" |
Kelly Stables Early Life and Education
Born in St. Louis, Missouri, Kelly Stables discovered her love for performing at a young age. She participated in school plays and local theater productions, which laid the foundation for her future career. Stables' passion for acting led her to pursue a degree in Theater Arts from the University of Missouri, where she honed her craft and further developed her acting skills.
Kelly Stables Transition to Television
Kelly Stables' breakthrough came with her role as Melissa in the hit series "Two and a Half Men." Her comedic timing and vibrant energy earned her recognition among audiences. The show's success provided her with a platform to showcase her talent, and she quickly became a fan favorite. Stables' portrayal of Melissa, Charlie Harper's quirky love interest, demonstrated her ability to infuse humor into her characters.
Kelly Stables Venturing into Drama
While Stables initially gained prominence in comedy, she showcased her acting prowess by seamlessly transitioning into dramatic roles. Her portrayal of Eden Konkler in the series "The Exes" highlighted her versatility. The character was a departure from her comedic roles, allowing Stables to explore a different facet of her acting abilities. Her ability to evoke emotion and depth in her characters garnered praise from both critics and viewers.
Comparison of Kelly Stables Roles
Role | Genre | Series |
Melissa | Comedy | "Two and a Half Men" |
Eden Konkler | Drama | "The Exes" |
Shahid Kapoor | N/A | N/A |
In addition to her on-screen work, Kelly Stables has made a name for herself in the world of voice acting. She lent her voice to various animated projects, including the role of Wendy in the animated series "W.I.T.C.H." Her ability to convey emotions through her voice added another layer to her creative repertoire. Stables' dedication to her craft and willingness to explore new avenues continue to set her apart.
Kelly Stables Personal Life and Achievements
Outside of her professional achievements, Kelly Stables is also a wife and mother. Her commitment to balancing her personal and professional life underscores her resilience and determination. While she may not boast an extensive list of awards, Stables' impact on the entertainment industry is evident through her consistent performances and ability to tackle diverse roles.
Kelly Stables Contemporary Contributions
Kelly Stables' recent appearance in the popular sitcom "Superstore" further solidifies her position as a talented actress. Her comedic prowess shines through as she portrays Kelly, a quirky employee in the fictional megastore. Stables' ability to seamlessly integrate herself into the ensemble cast demonstrates her adaptability and the rapport she establishes with fellow actors.
Kelly Stables' journey from her early days in St. Louis to becoming a respected figure in the entertainment industry is a story of dedication, growth, and versatility. Her willingness to embrace different genres and roles exemplifies her commitment to her craft. Stables' impact on both the comedic and dramatic realms of acting showcases her enduring influence in the world of entertainment.
Frequently Asked Questions (FAQs) About Kelly Stables
Has Kelly Stables won any awards for her acting?
While Kelly Stables hasn't received major award recognition, her consistent performances and contributions to the industry have garnered praise from fans and critics alike.
What are some of Kelly Stables' upcoming projects?
As of my last knowledge update in September 2021, specific details about Kelly Stables' upcoming projects are not available. However, given her track record, it's likely she'll continue to explore new roles and challenges in the world of acting.
What sets Kelly Stables apart from other actresses?
Kelly Stables' ability to seamlessly transition between comedy and drama, along with her voice acting talents, showcases her versatility. Her dedication to her craft and her willingness to evolve as an actress contribute to her unique standing in the industry.
How has Kelly Stables' personal life influenced her career?
Kelly Stables' role as a wife and mother has undoubtedly added depth to her acting, allowing her to draw from personal experiences to portray relatable characters with authenticity.


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More than a sport, a Kerala tradition, Champions Boat League 2022
Every year, the great backwaters of Kerala bear witness to one of the most incredible sights - the Champions Boat League. It's truly a visual treat to watch the magnificent snake boats (Chundan Vallom) course through the emerald backwaters creating an aura of zest and zeal.
Topics: Backwater Boat Race
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Plant your strategy with Nanuleu
Now available on Google Play Store
GUATEMALA CITY, July 14, 2016 -- Your world is a world of trees, that need to grow and multiply. In this world you represent life, light and color, everything that's good and everything that is in danger of imminent destruction. Plan carefully how to use your precious seeds and resources to expand your territory and fight corruption. Prove that you can survive in the world of Nanuleu.
Nanuleu is a RTS/Tower defense game where you control a network of magical trees that need to survive and defeat the enemies that come to destroy them. In this game your only task is to plant, but while doing so you need to choose between expansion, resource acquisition and defense. Your objectives are to capture certain points in the map before is too late and to destroy your enemies.
Nanuleu is a challenging game, you may need to play several times before winning. The game will generate a different map every time you play, so you don't get the same experience twice.
Nanuleu was created by Guatemalan developer Selva Interactive. It won second place in the Indie Game Maker Contest 2015. The game is available on the App Store and launching today on Google Play Store, in the languages: English, Spanish, Russian, Japanese and Chinese (Simplified). You can acquire it for $2.99. Nanuleu also has a Greenlight Campaign.
Selva Interactive is an independent game development company based in Guatemala City, Guatemala. It's goal is to create unique and valuable gaming experiences by focusing on gameplay and mechanics.
Press Contact


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ESDS' COO & Exec VP (Technology), Dr. Rajeev Papneja honoured with "EMINENT CIO'S OF INDIA" recognition.
With more than 23 years of experience in technology arena, both on National and Global front, Dr. Rajeev Papneja has made great contributions in the world of Cloud computing and Data Center technology. Rajeev holds... Read More
eNlight IoT
eNlight IoT Consider Internet of Things (IoT) as an environment where each and every objects that surrounds you like vehicles, flora, fauna, people and others are... Read More


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Driven Front-End Experts
We're trained web architects, Front End experts and Back End enthusiasts using technology to solve real world problems.
Trust. Ownership. Transparency. Commitment.
These are just some of the values that drive us. We believe working with the best partners is an opportunity to learn together. We're here to guide you to your best decisions, from refining and expanding your ideas to shipping products and services to customers. You can rely on us to choose and integrate powerful technologies that help your company grow sustainably.
We <3 Laravel and Vue
We're a place where coders share, stay up-to-date and grow their careers.


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Outcome Chart - British Columbia - Literacy Foundations - Social Studies
Skills and Processes of Social Studies
Specific Expectations
It is expected that students will:
- apply critical thinking skills, including questioning, comparing, summarizing, drawing conclusions, and defending, to a range of issues, situations, and topics
demonstrate effective research skills, including:- accessing information
- assessing and identifying sources of information
- collecting data
- evaluating data
- organizing information
- presenting information
- describe the attributes of active citizenship (e.g., ethical behaviour, open-mindedness, respect for diversity, and collaboration)
- Beyond Media Messages: Media Portrayal of Global Development
- Celebrities and World Issues
- Comic Book Characters
- Cop Shows
- Cyberbullying and Civic Participation
- Cyberbullying and the Law (Grades 7-8)
- Cyberbullying and the Law (Grades 9-12)
- Deconstructing Web Pages
- Finding and Authenticating Online Information on Global Development Issues
- Free Speech and the Internet
- Hoax? Scholarly Research? Personal Opinion? You Decide!
- I heard it 'round the Internet: Sexual health education and authenticating online information
- Images of Learning: Elementary
- Introduction to Cyberbullying: Avatars and Identity
- Media Kids
- News Journalism Across the Media: Introduction
- Perceptions of Youth and Crime
- Promoting Ethical Behaviour Online: Our Values and Ethics
- Taking Charge of TV Violence
- Taming the Wild Wiki
- Thinking About Hate
- TV Dads: Immature and Irresponsible?


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Set Up Turnitin in Canvas
It is recommended that all written assignments be run through TurnItIn to help students improve their writing skills and avoid plagiarism. The easiest way to do this is through the external tool process within Canvas assignments.
To create a TurnItIn Assignment:
- Click on your course page.
- Select Assignments on the course navigation menu.
- On the Assignments page, select the + Assignment button to create a new assignment.
- Scroll down to Submission Type, select Online, and either Text Entry or File Upload. (These are the only submission types compatible with Turnitin).
- Enter the number of allowed attempts.
- Select the Plagiarism Framework – TurnItIn option from the Plagiarism Review dropdown menu. This reveals the TurnItIn settings you may be familiar with.
- Complete the TurnItIn settings, including any exclusions, then Save or Save and Publish.
How to Create Assignment-TurnItIn
Accessing Originality Report in Canvas
How to CREATE an assignment using TurnItIn:
How to CONVERT a legacy TurnItIn assignment:
How to ACCESS originality reports within Canvas:


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New York and California are both advancing single payer plans through their legislatures. I have a lot of questions. They both assume incredible waiver authority will be given to them. These hypothetical waivers would direct federal program funding** to a state operated pass through entity to pay for healthcare. But each of these proposals will rely on some state level general taxation.
How do these programs work in a recession?
Depending on how one does the counting, between forty six and forty nine states have a balanced budget constraint. California and New York have balanced budget constraints. There is wiggle room for a bad year or two on the margins but it is incremental.
State tax revenue tends to be cyclical. Consumption and income taxes tend to go up when the economy is growing and down when the economy is in a recession. California heavily relies on capital gains taxation. New York relies on taxing Wall Street bonuses. Both of those are cyclical revenue sources.
Healthcare demand is responsive to recessions as well. Bad times lead to fewer elective surgeries and for more things to be deferred until they really are needed. The primary channel for that is through the increase in cost-sharing. The California and New York proposals don't have the cost sharing that could shift demand in time.
So my question is what happens to a state with a reasonably strong balanced budget constraint and state run single payer when there is a significant recession? Demand and costs will stay roughly constant. Revenue crashes. This dynamic opens a big financing gap. That gap must be closed. The methods to close that gap are massive provider payment cuts, increased taxes (which is probably a bad choice on a cyclical basis), increased cost-sharing, eliminating some covered services or borrowing for operational reasons. States have some wiggle room to borrow for operational costs but they don't have the ability to borrow 20% of their operational budget in a year for several years straight. Is it reasonable to assume that the states can access federal fiscal capacity to borrow as they have already accessed all federal healthcare money in a hypothetical waiver?
How does this work in a recession?
Help me out here, please!
** By the way, does that federal waiver money come with Hyde restrictions?
*** Any state single payer proposal post should always end in a Cato-esque "ERISA delenda est"