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Significance of Preexisting Vector Immunity and Activation of Innate Responses for Adenoviral Vector-Based Therapy. All the mice that had been infected with the VSV virus carrying the glycoprotein were fully protected from illness; the mice that had not been exposed to the VSV virus all died. The vaccine was licensed to NewLink Genetics, who in turn licensed it to Merck & Co. Once allowed to dry, the patches can be stored at room temperature . eCollection 2013. None (Open Label) Primary Purpose: Prevention. Ill take those odds in my struggles any day. 2018 May 14;92(11):e00363-18. It was a business decision for them that it would enhance their portfolio and make it easier to get funding to do the other work they were interested in, he said. Clipboard, Search History, and several other advanced features are temporarily unavailable. National Library of Medicine But in reality, more than 50 years of public and private . We had an enormous amount of know-how that was kind of complementary to the work that had already been done, said Dr. Julie Gerberding, Mercks executive vice president and chief patient officer for strategic communications, global public policy, and population health. They could potentially be utilized against other African viral and bacterial diseases other than COVID-19 [1]. The vaccine does not contain any live Ebola virus. Thats not what he got. Once inside the cell, the mRNA message could be translated into proteins, like the spike protein of SARS-CoV-2, and the immune system would then be primed to recognize the foreign protein. Health officials worldwide are sprinting to test whether experimental vaccines can protect against a deadly illness, after Equatorial Guinea confirmed its first outbreak of Marburg virus disease . This study will provide valuable data on the safety and immunological aspects of a novel multivalent Ebolavirus ChAdOx1 vaccine.. Since Ebola virus was first identified in 1976, sporadic outbreaks have been reported in Africa. Cancerous cells create unique pieces of protein that are not found on healthy cells. This vector has been previously used successfully in the ChAdOx1 nCoV-19 vaccine or the Oxford-AstraZeneca vaccine. Yet given the scale of the expanding crisis, experts were now scouring the medical literature, looking for any existing medicines that could be repurposed to fight Ebola, or experimental vaccines or drugs, regardless of where they were in the developmental pipeline. Still, the results were strong enough to convince Merck to push forward with the vaccine. While the risk of Ebola virus disease in the U.S. remains low, the U.S. government remains deeply committed to fighting devastating Ebola outbreaks in Africa, including the current outbreak in the Democratic Republic of the Congo, said Anna Abram, FDA Deputy Commissioner for Policy, Legislation, and International Affairs. While many hurdles remain and the 3D printer is likely years away from becoming available, experts hailed the "exciting" finding. Merck has also submitted the vaccine to WHOs Emergency Use and Assessment Listing procedure, a mechanism through which experimental vaccines, medicines and diagnostics can be made available for use prior to formal licensure. Access Nature and 54 other Nature Portfolio journals, Get Nature+, our best-value online-access subscription, Receive 51 print issues and online access, Get just this article for as long as you need it, Prices may be subject to local taxes which are calculated during checkout, doi: https://doi.org/10.1038/d41586-022-03590-y. Recent advances in the development of vaccines for Ebola virus disease. Initially, rings were randomised to receive the vaccine either immediately or after a 3-week delay, and only adults over 18 years were offered the vaccine. This is not a study. Only a randomized controlled trial. The campaign against these results was flabbergasting.. The mRNA vaccine technology also is being tested as a treatment for cancer. Already, mRNA vaccines are being tested for other infectious agents, such as Ebola, Zika virus, and influenza. T he U.S. Food and Drug Administration recently approved an important vaccine against Ebola, five years after an epidemic in West Africa killed 11,310 people and after more than 2,200 have died. Vector-based vaccines have been developed in the past for diseases including SARS, MERS, and most notably, the deadly Ebola virus; and mRNA vaccines have previously been tested to prevent the Zika virus. Safety and Immunogenicity of Novel Adenovirus Type 26- and Modified Vaccinia Ankara-Vectored Ebola Vaccines: A Randomized Clinical Trial. 8600 Rockville Pike Both the template and transcript can be produced in the laboratory using materials that are readily accessible. official website and that any information you provide is encrypted The earlier trials were to determine if the vaccine was safe to administer; the Phase 3s would tell the world if it actually worked. Suder E, Furuyama W, Feldmann H, Marzi A, de Wit E. Hum Vaccin Immunother. Sanofi Pasteur wasnt interested. In additional studies, antibody responses to Ervebo were assessed in 477 individuals in Liberia, approximately 500 individuals in Sierra Leone and approximately 900 individuals in Canada, Spain and the U.S. Was the vaccine safe to use? Study Start Date : October 2013. Neighborhoods where transmission had been intractable stopped producing cases after vaccination occurred. The approval was granted to Merck & Co., Inc. You are using a browser version with limited support for CSS. 2023 Jan 26;11(2):268. doi: 10.3390/vaccines11020268. In the spring of 2017, the National Academy of Sciences issued a report on conducting research during disease outbreaks that called into question the way the trial was conducted and its findings. ISSN 0028-0836 (print). The early years of mRNA research were marked by a lot of enthusiasm for the technology but some difficult technical challenges that took a great deal of innovation to overcome. Its just bringing together a number of discrete actions and discrete facts, which each alone would not have made it. It was about the vaccine being used in the trials, donated by the Canadian government. An experimental Ebola vaccine was highly protective against the deadly virus in a major trial in Guinea, according to results published today in The Lancet. In an editorial, The Lancet called the trial a remarkable scientific and logistical achievement., That such a trial was even possible is a testament not only to the skill of the research teams but also to the commitment of communities to defeating an epidemic that has devastated their nation, the journals editors wrote. Why are the vaccines not given to everyone at risk in endemic areas? These efforts, including todays landmark approval, reflect the FDAs unwavering dedication to leveraging our expertise to facilitate the development and availability of safe and effective medical products to address urgent public health needs and fight infectious diseases, as part of our vital public health mission.. Quite frankly, from a scientific prospective, it doesnt matter, agreed Kobinger. NIAID also is part of an international consortium conducting an ongoing clinical trial of various vaccine regimens using rVSV-ZEBOV and another experimental prime-boost regimen known as Ad26.ZEBOV/MVA-BN-Filo. Feldmann believed the switch would have no impact on whether the vaccine was effective. Ebola vaccine to begin human trials. While it can infect people, VSV doesnt sicken them. Modified mRNA vaccines are easily produced, safe, and are highly immunogenic. EVD has an incubation period that ranges from 2 to 21 days. Mobile biocontainment unit used to monitor a German researcher who had pierced her finger with a syringe containing Ebola virus during an experiment in 2009. The government in Guinea was also keen to host a trial. NIAID and WRAIR are conducting a clinical trial examining the safety and dosage of an investigational vaccine designed to protect against Sudan virus (known as cAd3-EBO S) at Makerere University in Kampala, Uganda. The University of Oxford have begun recruiting for a Phase I trial to test an Ebola vaccine in human volunteers with the first vaccinations having already taken place. The rVSV-ZEBOV vaccine uses a genetically engineered version of vesicular stomatitis virus (VSV), an animal virus that primarily affects cattle, to carry an Ebola virus gene insert. Helen Branswell covers issues broadly related to infectious diseases, including outbreaks, preparedness, research, and vaccine development. Because of the public health importance of a vaccine to prevent EVD, the FDA worked closely with the company and completed its evaluation of the safety and effectiveness of Ervebo in less than six months. Confirmed outbreaks of EVD have been documented since the 1970s, primarily in areas of sub-Saharan Africa, where scientists believe the virus is always present at low levels in certain infected wild animals. mRNA production is cell-free, using in vitro transcription methodology. It did so with support from BARDA, which began funding rVSV-ZEBOV during the West African outbreak. This is a brilliant story. The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The WHO convened a meeting to determine the best path forward. The reality was that, for years, scientists who studied Ebola, which belongs to a family of viruses called filoviruses, had poured their hearts into work to develop vaccines and drugs to combat these deadly scourges. Phase 3 trials for Ebola vaccines could start in early 2015 with initial safety data possibly available by June 2015. Before The agencys director, Rick Bright, estimated that it has spent about $175 million supporting production of vaccine and validation of Mercks production facility for the vaccine in Germany. PubMed I always had to defend it, and we always were scrambling for money, he said. 2023 Jan 24;15(2):330. doi: 10.3390/v15020330. They thought it was premature to advance it, recalled Kobinger, who said he was told that Guinea lacked the infrastructure to approve use of an experimental vaccine. It, too, was turned down. It was to be used to produce test lots of human-grade VSV vaccine for Ebola Zaire, the species of the virus that has been the most common cause of Ebola outbreaks. The biggest challenge was that mRNA would be taken up by the body and quickly degraded before it could deliver its messagethe RNA transcriptand be read into proteins in the cells. You can view all news or browse by category, Illustration showing how the Ebola virus looks under a microscope, ProspectiveContinuing Educationstudents, Prospective online/distance learning students. Scientists concluded that the vaccine did not prevent HIV, nor did it increase the chances of obtaining the disease. It had not. 2023 Feb 1;31(2):374-386. doi: 10.1016/j.ymthe.2022.10.011. Kieny waxed a bit philosophical about the unlikely success of rVSV-ZEBOV. In place of a placebo control, the rings were randomly assigned to either immediate vaccination, or vaccination after a 21-day delay. This became the Canadian vaccine how it was known for many years. The Ebola virus causes a disease called Ebola hemorrhagic fever. Bethesda, MD 20894, Web Policies By that point, there were already 49 cases and 29 deaths, making it larger than about half of all previous known Ebola outbreaks. This study will test the safety of an experimental vaccine developed to protect against Ebola virus infection and to determine if the vaccine induces an immune response to the virus. Marie-Paule Kieny, who then headed the division of the WHO tasked with trying to spur development of drugs and vaccines for diseases like Ebola, noted the company had never conducted a clinical trial. Two serious adverse events were judged to be related to vaccination (a febrile reaction and one anaphylaxis) and one was judged to be possibly related (influenza-like illness). But thats not proof, of course, said Kieny of the WHO. To see if the system worked, his group added a protein from an influenza virus to VSV and injected it into mice. PMC NIAID is sponsoring the study, called HVTN 302, and the NIAID-funded HIV Vaccine Trials Network (HVTN . The study will assess the immune response and safety of the new vaccine against the Zaire and Sudan species of . The trial ultimately enrolled 1500 participants and results indicated that the vaccine was well-tolerated and induced an immune response among participants. Unlike some viral vaccines, mRNA does not integrate into the genome, obviating concerns about insertional mutagenesis5. On July 31, 2015, less than a year after the Canadian government donated the vaccine, the findings of the trial were published by the journal The Lancet. As part of this agreement, Merck committed to ensure that 300 000 doses of the vaccine are available for emergency use in the interim, and to submit the vaccine for licensure by the end of 2017. Malik S, Kishore S, Nag S, Dhasmana A, Preetam S, Mitra O, Len-Figueroa DA, Mohanty A, Chattu VK, Assefi M, Padhi BK, Sah R. Vaccines (Basel). Some cancer drugs work immunologically by destroying cancer cells, so mRNA vaccines could work together with other methods to help the body control a cancer," Levin said. Self-amplifying RNA vaccine protects mice against lethal Ebola virus infection. She spent two years on this alone, I think, said Kobinger. I think probably it would have never happened, Kobinger said. Vesicular stomatitis virus-based vaccines protect nonhuman primates against Bundibugyo ebolavirus. at the Johns Hopkins Bloomberg School of Public Health. The agency also is responsible for the safety and security of our nations food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products. The gene inserts express an Ebola virus protein designed to prompt the human body to make an immune response. Incredible mind, incredible heart: After decades fighting Ebola, a beloved expert hangs up his boots. That has never happened, said Feinberg, who is now CEO of the International AIDS Vaccine Initiative. The vaccine is the first to prevent infection from one of the most lethal known pathogens, and the findings add weight to early trial results published last year. Already, vaccine manufacturers are developing mRNA vaccines to protect against other respiratory viruses such as the flu. The .gov means its official.Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. The vaccine is based on the ChAdOx1 virus, a weakened version of a common cold virus (adenovirus) that has been genetically modified so that it is impossible for it to replicate in humans. Exclusive analysis of biotech, pharma, and the life sciences. Can the vaccine cause adverse effects? Ebola ACIP Vaccine Recommendations. I thought everybody would be happy to say: This is great. But actually, this is when the bashing started. Two U.S. Food and Drug Administration (FDA)-approved mRNA vaccines for COVID-19 have saved millions of lives. The vaccines one made by drug giant Pfizer with German biotech firm BioNTech, another by US pharmaceutical company Moderna sped through clinical trials in just months and gained approval from major regulatory bodies less than a year after development began. Feldmann and others believed the latter was more likely. The WHO and others including players in the U.S. government began casting about to find a more experienced pharmaceutical company to partner with, or to acquire the vaccine from NewLink. The success of the first licensed mRNA-based vaccines against COVID-19 has created a widespread interest on mRNA technology for vaccinology. This is how it started.. The vaccine platform was initially developed in the early 1990s, in an effort to create safe and effective vaccines in a pandemic situation. NIAID, along with other groups, supported Phase 1 trials of the vaccine regimen. In June, however, the trials data and safety monitoring board concluded there were not likely to be enough additional cases to change the outcome of the study. NIAID, under a clinical research collaboration with the Liberian Ministry of Health known as PREVAIL, also conducted a Phase 2 randomized, placebo-controlled clinical trial of the vaccine in Liberia during the 2014-2016 outbreak of Ebola virus disease. These vaccines were developed with NIH support and research on a protein found on SARS-CoV-2, the virus that causes COVID-19. What was an appropriate dose? ISSN 1476-4687 (online) If two assets hadnt come researchers way, its almost a certainty that Ervebo would have never come to fruition. The University Medical Center Hamburg, where she was taken, reached out to Ebola researchers in the U.S. and Canada to see if there was anything that could be done. The vaccine ink is made up of lipid nanoparticles containing mRNA vaccine molecules, as well as a polymer similar to sugar water. 2013 Dec 19;7(12):e2600. In March 2022 Moderna announced the development of mRNA vaccines for 15 diseases: Chikungunya virus, COVID-19, Crimean-Congo haemorrhagic fever, Dengue, Ebola virus disease, HIV, Malaria, Marburg virus disease, Lassa fever, Middle East respiratory syndrome coronavirus (MERS-CoV), Nipah and henipaviral diseases, Rift Valley fever, Severe fever Onset of symptoms of EVD can be sudden and can include fever, fatigue, muscle pain, headache and sore throat. Yale patented Roses VSV construct, and licensed it to Wyeth Pharmaceuticals. Pfizers COVID-19 vaccine is the first mRNA product to achieve full FDA approval in the U.S. Please enable it to take advantage of the complete set of features! An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat? The neutralizing antibody responses were fast and off the charts, he said. On so many levels against all odds, it made it, said Kobinger, now director of the Infectious Disease Research Center at Laval University in Quebec. It was there, in 1967, that laboratory workers and people related to them became sick with what was later named the Marburg virus. Novartis had sold its vaccines division to GSK earlier that year. The vaccine is the first to prevent infection from one of the most lethal known pathogens, and the findings add weight to early trial results published last year. The fever subsided; the woman did not develop overt symptoms of Ebola. Follow her on Mastodon and Post News. The Guinea vaccine trial the trial that almost hadnt happened was the only one to reach a conclusion. Health workers in protective clothing speak with people awaiting medical treatment in the outpatient lounge of Redemption Hospital, formerly an Ebola holding center, in Monrovia, Liberia, in 2015. Game Changers: 5 Global Vaccine Innovations on the Horizon, World Immunization Week: Preventing a Global Measles Outbreak, With Rehabilitation Care, You Can Live Your Life Again, Gain-of-Function Research: Balancing Science and Security, Inclusion, Diversity, Anti-Racism, and Equity (IDARE), For mRNA Vaccines, COVID-19 is Just the Beginning, The New Technology Behind COVID-19 mRNA Vaccines and What This Means for Future Outbreaks. When autocomplete results are available use up and down arrows to review and enter to select. One was money, the other was a rare talent. Epub 2018 Jun 18. Merck agreed to pay NewLink $50 million for the license. So good written and hugely interesting. The purpose of this study is the evaluation of the safety and immunogenicity of two candidate Ebola vaccines Ad26.ZEBOV and MVA-BN-Filo, in a 2-dose heterologous regimen. It was apparent to everyone that NewLink didnt have the expertise or bandwidth to take on this work. The RNA sequence used in the COVID-19 vaccine developed by Pfizer and . To proponents, ring vaccination, a type of adaptive trial design, was the most feasible approach. The U.S. Food and Drug Administration announced today the approval of Ervebo, the first FDA-approved vaccine for the prevention of Ebola virus disease (EVD), caused by Zaire ebolavirus in individuals 18 years of age and older. Individuals who provide care for people with EVD, including health care workers who do not use correct infection control precautions, are at the highest risk for infection. jay sanders radio commercial, colonial property management mesquite, nv, fake dna test results negative,
The Potomac School Endowment,
Articles E


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A 58-year-old man from North Saanich is dead following a collision between a motorcycle and a truck on Monday afternoon.
Saanich police said they received multiple 911 calls just after 12:30 p.m. about a crash involving a truck and a motorcycle at the intersection of Boleskine Road and Whittier Avenue. The motorcyclist was taken to hospital where he succumbed to his injuries.
Boleskine Road in Saanich is shut down in both directions. Police, including officers from the Saanich Police Crash Analyst Team, are still at the scene and expect to have Boleskine Road closed to vehicles and pedestrians for most of the evening. They are asking people to plan alternate routes.
Police are still investigating the cause of the crash and have not released the identity of the man. Anyone with information is asked to call Saanich police at 250-475-4321 or Crime Stoppers at 1-800-222-8477.
We're currently dealing with a serious MVI Boleskine/Whittier. Boleskine is shut down in both directions. Pls avoid #yyjtraffic #saanich pic.twitter.com/avK9jHt3K0
— Saanich Police (@SaanichPolice) September 11, 2017

subset: commoncrawl


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The need for continuous funding for health care to ensure access for all has been underscored by Prime Minister Mia Amor Mottley.
At the same time, she has made a call for the urgent establishment of a Caribbean calorie counter to help Caribbean people be more aware of the number of calories they are consuming in their favourite, local foods on a daily basis.
The Prime Minister made the comments as she addressed the Pan American Health Organisation's (PAHO) 120th anniversary cocktail reception at the Hilton Barbados in St. Michael on Sunday night.


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A mobile library whose stories should make us laugh and everything else
The Bible
I went into the Bookshop and headed as I do to the Religious section. I noticed a Brian McLaren book 'Faith after Doubt'. I read the preface after which I was thinking "This book probably signals the significant change in Evangelical Christianity that I have observed over the past years."
That change is allowing Evangelical Christians to express their passion for Jesus without barriers of beliefs particularly about sex and other faiths.
I then took some time out in the Library searching for further thoughts on Jonah. Our Christian Life Comunity is still contemplating Jonah so I was interested to see what else I could learn about him.
I came across the following webpage I was impressed with the animation.
I actually learned some things I never knew about Jonah. I hadn't realised he gets a mention in 2 Kings chapter 14 verses 23 -25 concerning a prophecy he made during the reign of King Jeroboam (the second). According to the video the prophet, Amos was a contemporary who also advised the King in this battle. This shows my lack of Biblical knowledge as I have never been able to place prophets within their time. I continue to think of the Bible as a chronology of events with time marked by the books which it is not.
This short video also reminded me that this is a story before anything else and literary devices are used to make it a good one. I hadn't thought of it as satire until it was said on the video. It threw a new light on my reading and also pointed the message back to me.
I then visited the shelves and came across Nadia Bolz-Weber book Shame-less. I have previously come across Nadia as she stands out as a Lutheran priest covered in tattoos.
Shameless is to Nadia what his 95 Theses were to Luther. She wants a sexual reformation within the church that is less bothered with sex and actually celebrates it.
Again I was bumping into that change that is occurring within Christianity.
If I am into something it is the Bible. Actually, if I am into something it is God, no if I am into something it is being a father. Perhaps I am into more than I thought. But yes the 66 books that make up that mobile library we refer to as the Bible holds a big interest in me.
In looking at these three places this morning I was reminded they are books telling a story, not theology. I would do well to remind myself to read the stories and leave aside the theology that has layered them.


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Alexander Viro wrote:
> > I'd be happy with this - admit up front that the data is not always
> > available. Sometimes the filesystem might _wish_ for it, but we can't
> > always have what we wish for ;)
> Wonderful. If that is done (and ->readpage() on symlinks falls into that
> cathegory - no struct file* around) I have no problems with passing struct
> file *.
I have one question. Does this work with NFS servers that return
different symlink values for different users? Or is that still reliable
by turning off cacheing at the client?
-- Jamie
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In order to keep you, your family and all our staff safe we have introduced measures to reduce the risk of spreading coronavirus. In line with government guidance the changes to your service are explained below. To keep up to date with service changes please visit www.swindon.gov.uk/coronavirus.
- Where possible all non-essential home visits will be replaced with a telephone call or email
- If a home visit is considered essential, you will be asked a series of health related questions before your appointment is considered
- Tenant meetings will be postponed until further notice
Please keep safe and stay indoors.


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'General Hospital' Friday Spoilers: Mary Pat's Death Sends Shockwaves, Ava Is Rattled, & Nina Reassures Sasha
Friday's episode of General Hospital will be a juicy one according to the latest spoilers. Mary Pat's head was found floating in a barrel of apples and this is going to leave many in Port Charles rattled. In addition, Nina will be feeling protective of Sasha when Ava leaves her rattled and Ava's going to be facing a fright at the gallery.
General Hospital spoilers via the sneak peek shared on Twitter reveal that Carly will be left feeling quite shaken by the discovery of Mary Pat's head. Of course, Carly didn't get along with the Ferncliff nurse at all, but she still finds it hard to imagine that anyone would do something so awful to her.
Chase and Jordan will be asking plenty of questions about the gruesome discovery and Laura will note she's stunned that something like that could happen. Ryan will talk to her about having run into Mary Pat, but he'll put a spin on it to avoid any suspicion for the cruel murder falling onto him. Of course, at this point, there's no reason why anybody would suspect him of having harmed the Ferncliff nurse.
Nina and Sasha will have a chat and General Hospital spoilers suggest that Sasha will say something about Ava that propels Nina into mama bear mode. Nina will tell her newly-found daughter that she'll take care of Ava and she won't want Sasha to worry about.
"Who could've committed such a heinous act?" #GH55 pic.twitter.com/AzAr5KqoJL
— General Hospital (@GeneralHospital) November 2, 2018
Griffin and Kiki will be having a discussion about Ava as well. Griffin will tell his gal that the problem between Kiki and her mom all ties back to him, but Kiki will probably point out to him that she and her mother have had a complicated relationship for years. Kiki isn't about to ditch Griffin just to try to patch things up with her mom, but she'll probably appreciate his efforts.
Ava is in for a scare of some sort herself. General Hospital spoilers tease that she'll see something alarming at her gallery and whatever it is will have her screaming and reeling backward. Of course, some fans speculate that perhaps something related to Mary Pat's murder has been planted there, but it may be something far less ominous that's about to play out as well.
SheKnows Soaps details that Scotty will pop up during Friday's show, wanting to help someone, and Ava is going to be trying to defend a decision she made. General Hospital spoilers hint that a lot of this chaos will carry over into the episodes airing during the week of November 5 and it sounds as if fans have a lot to look forward to as this month plays out.
Ryan wants this Halloween to be unforgettable, West Coast. What does that mean for Felicia? A spine-tingling, new #GH starts RIGHT NOW on ABC! pic.twitter.com/iRtbyc6S6w
— General Hospital (@GeneralHospital) October 31, 2018


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The higher the number of processor threads, the better for optimization speed.
Select the amount of RAM based on the tasks and the calculation algorithm described below.
The final memory consumption during optimization can be calculated using the following formula:
Memory (bytes) = Number_of_Bars * 8 * Number_of_Unique_Parameter_Sets
- Number of Bars – how many history bars have you passed to the script
- 8 – the number of bytes that one double number occupies
- Number of Unique Parameter Sets – the number of unique combinations of parameters in the script. This value is not always equal to the number of iterations in the script. For two moving averages with a period from 1 to 300, the number of unique sets will always be 299, while the number of recalculations will be much larger. And by caching these 299 unique results, the optimization speed gain will be obtained, which is achieved by using GetData.
One gigabyte is always 1024 megabytes, and one megabyte is 1024 kilobytes, and a kilobyte is always 1024 bytes.
Within the program, one double number can take up to 10 bytes. TSLab allocates memory not only for the cache, but also for other intermediate calculations, and the closing prices of the instrument are also cached (which may take up some amount of memory). Therefore, memory will be spent a little more than in the calculations according to the above formula.
The program fully supports multithreading. Therefore, the more threads the processor supports, the faster the optimization is, with a sufficient amount of RAM.
The faster (high frequency) the processor and the more cores (possible threads), the faster the optimization. Read the related article:
You can open the Script Optimization menu by selecting File -> Program Settings -> Script Optimization
For multi-core processors, enable the "Should be used on multiprocessor (or many cores) systems" option
- Script debugging - this is a debugger for working with Visual Studio or SharpDevelop
- Script execution timeout - the default is 40 seconds. This is the time to recalculate the script. If the computer was unable to calculate the script within the specified time, the program will stop recalculation and remove the task. The setting affects not only the optimization, but this parameter is the maximum time for calculating the agent.
- Script cache size - is selected by the brute-force search method. All computers are different, even with the same hardware. Depending on the drivers, installed programs, OS version and running services, they may behave differently. With an excess of RAM and working in 64bit on the latest versions of Windows, this parameter can be left alone or set close to the available free physical RAM.
About the brute-force search method from the user:RAM is engaged in storing data, from where it is consumed and recalculated by the processor. A larger amount of RAM will allow you to place a larger amount of calculated data there without the need to extract this data from the HDD. The processor is responsible for the recalculation itself, respectively, the optimization speed will be determined by the balance between the amount of RAM and the processor speed. Increasing the RAM without increasing the processor speed will not have an effect after passing the point of maximum RAM load, just as increasing the processor frequency will have a lesser effect with low RAM, because data will have to be taken from low-speed data storage devices such as HDD and SDD.The "brute-force search method" in this case implies the need to find a balance between the amount of data that needs to be optimized, processor frequency, RAM size, HDD / SSD speed and the number of processes already running in your system.This is the "brute-force search method". You can play Need For Speed on your computer while optimization is running. It is clear that, all other things being equal, optimization in this mode will be slower than on the machine on which the game is not running. It seems that this is exactly what was meant in the documentation for TSLabAlexandr Ganov
- Optimization threads number - 0 means that the program will use the number of threads based on the number of cores.In the example, the picture shows a regular dual-core 2ghz xeon. It has 2 threads by default, since there are two cores. However, if you use hyper-threading processors, for example i7, then the number of threads can be taken by the number of cores, multiplied by two. The optimization speed will increase significantly.
- Stop opt. if RAM is not enough - the program will stop optimization if the RAM resources are exhausted. If you uncheck the flag, Windows can take processes to SWAP (when using 64 bits) or throw a memory exception error (when using 32 bits)
- Should be used on multiprocessor (or many cores) systems - the setting is available since version 2.1. This is a NET garbage collector setting. For example, for multi-core xeon (more than 8 cores), configuration is required, even regardless of the Windows version (server or not). With fewer cores, the setting may not affect the processor load.
- Brute force - Direct enumeration of parameters with a given step from smaller to larger, in turn.
- Random - Enumeration of parameters with a given step, in random order
- Genetic - Read more in the article API. Plugins. Implementing IOptimizationMethod
Optimization parameters are enabled in the block properties.
Let's set the boundaries of the parameter optimization, for example, 1 - 100, step = 1. In total, a maximum of 100 iterations.
But if you set 30 iterations, not the maximum (100), then the optimizer will go through not exactly 30 iterations, but 34-35.
"Number of iterations" specifies the minimum number of iterations. In general, the number should be a multiple of the number of parameters involved.
The Optimization Results table appears at the beginning of the optimization process unless the Save to Excel option is selected on the Optimization page. The table has a column Result from script. In the toolbox, the editor has a Result for optimization block. The block code is here: https://github.com/tslab-hub/handlers
The block outputs the value from the Result for optimization script into a column by block name.
There can be several results for optimization (limited by common sense)
Nothing is counted in the column, i.e. the block simply outputs the value from the Result for optimization to the Optimization Results table. For example, some characteristics evaluating a strategy.
If the Optimization Results table does not load, check the filter settings:
Click the Save parameters button in the "Optimization" tab. Give a name to the parameter set. This set of parameters will be available in the "Parameters" tab
There are several quotes. It is necessary to run the script for these quotes with certain sets of optimizing parameters and save the results to a file. Is it possible to solve this problem by creating an additional script that will perform the above task? It would be very convenient to put the script at night so that all planned optimizations are performed at night. Since optimizations can take 2-3 hours, it would be convenient to schedule several calculations to run overnight. Which will significantly speed up the optimization process.
It is not possible to queue several optimization tasks with built-in tools in TSLab. We have plans to implement these opportunities in the future.
Will there be GPU optimization in the program? The GPU is not capable of doing all the calculations, and in this case it is technically impossible to do, so the answer is no.
Last modified 2yr ago


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This year the condition of dengue got severe because the outbreak reported in parts of country due to a new starin of dengue virus (DENV) suspected killing dozens of people in uttar pradesh alone.
A new variant of dengue has been observed in 11 states of India.The most important precaution is to not let water stagnate around you and to wear full sleeves.
This virus is dangerous is more dangerous because it can cause fever , vomiting, joint pain and can even cause lethal problems and shock syndrome.
How to stay safe from mosquito born deseases - drink clean water , wear full sleeves, when you go out in the evening apply mosquito repellent.
Also keep your food fresh and covered to avoid food borne deseases. Stay Safe Stay Healthy and always remember precaution is better than cure.


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On the end of the celebrations for obtaining the World Cup, hundreds of fans staged serious incidents on Tuesday night when they confronted the police officers who were trying to evacuate the people who were still in the area of the Obelisk and even the moment there is a total of 14 detainees Y 21 troops wounded.
When most of the people had already left the place, some attackers began to throw stones and bottles against the few uniformed men who were at the entrance to the historic monument of the City of Buenos Aires, who, in turn, responded by shooting rubber bullets.
According to what was reported, the riots began when the Infantry and Firefighters tried to lower two men who had entered the Obelisk, after its door was again forced by protesters, and they remained on top. Personnel from the Special Rescue Group (GER) and agents of the City Police were attacked by a minority group of demonstrators with stones and blows with bottles. There they detained four people inside the monument.
Then the eviction of the vicinity of the Obelisk and the downtown area of the City of Buenos Aires was also ordered, where 10 more people were apprehended.
It may interest you: Popular fervor and improvisation: the reunion of the fans with the world champions that ended in helicopters over Buenos Aires
In fact, as stated by infobae sources from the City Police, so far there had been a total of 14 detained aggressors and 21 injured, among members of that same security force and the Fire Department.
Furthermore, the attackers several objects were set on fire that they left in full Avenue July 9 and on the Metrobús lane, while the Police formed a cordon to prevent the columns from advancing towards other parts of the City, while some trucks and a hydrant car of the force arrived at the scene of the events to provide support.
Around 9:20 p.m., the situation was already under control. and the avenue had been completely freed, although it was still full of garbage that was generated throughout the day.
The same police sources specified that in the morning several people managed to completely tear down the bars that surrounded the Obelisk, which had already suffered damage in the festivities last Sunday, shortly after the Argentine team defeated the French team and was consecrated in Qatar. .
The fans concentrated on the entire 9 de Julio to await the arrival of the group with the world champion players, which was originally going to go through that place to greet them, but which finally had to change its route due to the crowd that was there.
It may interest you: More than 4 million people took to the streets to celebrate the title with the National Team: the Obelisk, the Plaza de Mayo and the AU collapsed May 25
"It was already impossible to continue (with the operation) due to the number of people and because the boys (of the National Team) were put at an undesirable risk, and the same people as well. I believe that these images are also seen in the world: it is very difficult to manage an entire city that takes to the streets, "he said in this regard. Alberto Crescentidirector of SAME, in statements to TN.
On the other hand, in the midst of the riots, a criminal also stole a printer from one of the premises in the area, which according to the first versions would be a bank, but was identified and captured after a few minutes.
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Serious incidents at the Obelisk: fans who had gone to wait for the Argentine team attacked the Police and 21 troops were injured


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constitutional, common sense, conservative
District 14 is one of 26 districts in Ozaukee County and is in the heart of the Village of Grafton, comprised of voting wards 5, 6, 7 and 8. Each district represents about 3,500 citizens.
Ozaukee County is divided into 26 districts with each district representing about 3,500 citizens. In general, a district represents a single municipality but in some cases a district is made up of two municipalities which is the case with District 15 having both the Village of Grafton and the City of Cedarburg.
County Board
The County Board is the governing body of Ozaukee County. Twenty-six districts elect one supervisor each for a two-year term. Elections are held the first Tuesday in April of even numbered years.
The Role of the County Board
The Ozaukee County Board is the leadership body which makes policy determinations regarding:
Standing Committees
Standing Committees is where a lot the work gets done in regards to the County Board. These committees are comprised of County Supervisors, other County employees, and citizens from the community. In most cases County Supervisors serve on one committee with a few serving on two. The committees are:
To see agendas and meeting times click on the committee above.
*I am currently working on the Health & Human Service committee but have worked on the Public Safety and Public Works in the past.
County Board Meetings
The County board typically meets twice a month on the first and third Wednesday of the month at 9:00AM. The Standing Committees meet once a month with the date and time varying per committee.
Ozaukee County's annual budget was $91 Million in 2021. The county is one of the 10 largest employers in Ozaukee County with 800 plus staff, 450 of which are full-time. The debt expense is less than 2 percent of total expenditures.
Personnel - salaries & benefits
Purchased - salaries & benefits
Property and sales taxes fund about 33 percent of county operations. The annual sales tax collections of $10 Million go directly to offset property taxes. Public fees for services fund county business operations and State and Federal Revenues comprise about $18 Million of annual revenues
State & Federal - HHS & Highway
Four county departments account for 76 percent of county expenditures and about half of county employees work at our senior care campus, on county roads in public safety, and in human services.
For every dollar of property tax collected from taxpayers, county government is about one dime on average. In 2021, the County's 10% is about $21 million.
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There's a fun clicking sound when you push down the handle. There's even a toilet paper holder. With songs to learn and encouraging phrases and sounds to discover, the Cheer for Me! Potty really does make potty training fun! Because it looks similar to a real toilet, it encourages kids to make the transition to the grown up "potty". Requires 3 AA batteries.
- Better for Baby…
- Songs and sound effects reward success and provide motivation for return trips.
- Realistic elements of potty encourage transition to grown-up toilet.
- Bowl removes for easy cleanup.
- Can be used on a regular toilet seat to help with transition.
Better for Mum…
- Realistic toilet-training chair for toddlers
- Rewards your child's success with fun songs, sounds, and encouraging phrases
- Removable potty ring helps your toddler transition to a real toilet (Not recommended for use on padded toilet seats)
- Flip-up splashguard and removable bowl for easy cleanup
- Handles on potty ring help toddlers feel secure


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For Release May 15, 2022
Baton Rouge, La – Today, MetroMorphosis announced that applications for the 10 for 10 Community Fund are open. As a part of its 10 Year Celebration, MetroMorphosis is investing $10,000 into 10 community change efforts in Baton Rouge. The effort is designed to promote community-led change making in neighborhoods. Each change-effort will receive $1,000 and strategic support. By investing in these projects at the neighborhood level, MetroMorphosis seeks to support the organizations or individuals who do the work daily and mobilize others to help make their communities more vibrant, thriving places to live and work.
The organization believes that community members and people with lived experiences who interact and maneuver the challenges in their communities are the ones who must be supported in developing and executing the solutions. At the core of the organization, there has always been a belief that people must lead and own the change that they wish to see. The 10 for 10 Community Fund serves as a resource to do so.
"We envision a critical mass of engaged citizens equipped and developed to own the vital role of positively impacting their neighborhoods. By investing dollars and strategic support in 10 change efforts around Baton Rouge, we hope to not only assist those with great ideas or those already doing the work, but also encourage them to seek out additional resources, tools and people who aim to make an impact for years to come." Raymond A. Jetson, Chief Executive Catalyst.
The ideal candidate for this award are community members who live and/or work in inner-city Baton Rouge, are interested in transforming their neighborhood, and have a project or idea that will motivate others to share the responsibility and desire to influence the community beyond this particular project.
Learn more about the 10 for 10 Community Fund and apply between May 16 and June 17, 2022 at www.MetroMorphosis.net/10for10.
For more information, contact Tamiera Nash, firstname.lastname@example.com


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Israel and Hamas entered the planned final day of a four-day cease-fire Monday, with expectations for Israel to release more Palestinian prisoners and Hamas to set free more hostages amid a push to extend the truce.
Hamas has indicated it would extend the deal, while Israeli Prime Minister Benjamin Netanyahu reiterated Sunday that Israel would welcome an extension that included Hamas releasing 10 more hostages per day.
The initial agreement, which went into effect after six weeks of war, included Hamas releasing 50 hostages, Israel freeing 150 Palestinian prisoners, and a pause in fighting.
The United Nations said late Sunday a total of 39 Israelis, 117 Palestinians and 19 foreign nationals had been released.
The United States, Egypt and Qatar are among those advocating for an extension after working to secure the four-day cease-fire.
"That's my goal, that's our goal, to keep this pause going beyond tomorrow so that we can continue to see more hostages come out and surge more humanitarian relief into those in need in Gaza," U.S. President Joe Biden told reporters Sunday.
Biden also welcomed the release of a 4-year-old Israeli American girl whose parents were killed in the Oct. 7 Hamas attack on Israel.The girl, Abigail Edan, was among 14 Israelis and three foreign nationals turned over to the International Committee of the Red Cross on the third day that Hamas released hostages in exchange for Israel freeing Palestinians who had been jailed for various offenses.The White House said in a statement that Biden and Netanyahu spoke about the hostage release in a phone call Sunday and that they discussed the pause in the fighting and surge in additional humanitarian assistance into the Gaza Strip.The temporary truce is the first halt in the conflict since Hamas, in a surprise attack on Israel on Oct. 7, killed 1,200 people and seized about 240 hostages. Israel in turn vowed to eliminate Hamas and bombarded Gaza with aerial attacks and a ground offensive that Palestinian officials say has killed more than 14,000 people, about 40% of them children.
In Barcelona, EU foreign policy chief Josep Borrell called the four-day truce an "important first step," but said much more is needed to "alleviate the dire situation in Gaza and to find a way out of the current crisis."
"The pause should be extended to make it sustainable and long-lasting while working for a political solution," he said Monday at the start of a meeting of the Union for the Mediterranean.
Borrell said the "indiscriminate brutality" of the Hamas attack on Israeli civilians cannot be justified, but said "one horror cannot justify another horror" as he noted the widespread destruction in Gaza from Israel's military campaign.
China said Monday its top diplomat, Wang Yi, will preside over a Wednesday U.N. Security Council meeting focused on the Israel-Hamas situation.
Chinese foreign ministry spokesperson Wang Wenbin told reporters that China hopes the talks would lead to a cease-fire and an end to the fighting, and alleviate the humanitarian crisis in Gaza.
The pause in fighting has allowed an increase in the badly needed humanitarian aid reaching Gaza, where the U.N. says an estimated 1.7 million people—about three-quarters of the population—are displaced.The U.N. Office for the Coordination of Humanitarian Affairs said late Sunday that cooking gas reached Gaza but that the amount was still well below what people need.The agency also continued to describe "overcrowding and poor sanitary conditions" at U.N.-run shelters where half of those forced from their homes by the conflict are staying.


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I am trying to solve the following problem:
A radioactive atom is moving in the $x$ direction in the laboratory at speed $0.3c$. It emits an electron having speed $0.8c$ in the rest frame of the atom. What will be the velocity of the electron in the laboratory when it is ejected in the $y$ direction in the atom's rest frame? (Find $u_y$, $u_x$, $|u|$, and $\theta$.)
I thought that since the atom is moving in the $x$ direction relative to the laboratory, then any motion in the $y$ direction relative to it must be the same for the laboratory. However, when I put $u_y = 0.8c$, the teacher marked it wrong; he refuses to explain why. Why is $u_y \neq 0.8c$?


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Alan Renwick gives evidence to a committee on democratic accountability in the Assembly of Alberta
29 September 2020
Alan Renwick appeared last week before a committee of the Legislative Assembly of Alberta, Canada to give evidence on citizen-initiated referendums.
The Select Special Democratic Accountability Committee has been established to examine a proposal for the introduction of citizen-initiated referendums in Alberta. Dr Alan Renwick, Deputy Director of the Unit, took part in the committee's first evidence session, on 23 September.
Drawing on the findings of the Independent Commission on Referendums and his own international research, Alan began by setting out some key aspects of citizen-initiated referendums that the committee might consider. He highlighted the type of referendum: whether it is an 'abrogative' vote (repealing an existing law or stopping a newly passed law from coming into force) or an 'initiative' (allowing voters to introduce a new policy or law). He also mentioned whether the result of the referendum is binding or advisory, and how signatures to call the vote are collected.
Alan then focused on the pros and cons of citizen-initiated referendums. He explained that such referendums can bolster democracy by giving people a direct voice in decision-making, and he noted that research suggests they tend to lead to policy outcomes that are closer to the preferences of the average voter.
On the other hand, Alan cautioned that citizen-initiated referendums often fail to encourage or facilitate meaningful deliberation. If badly designed, they cut out the legislature – the normal forum for such deliberation – from the legislative process. That can have harmful effects on the quality and sustainability of the measures passed. Such initiatives can also be dominated by campaigning voices, which in turn has the potential to silence rights and concerns of vulnerable minorities.
Alan noted that there are several ways in which deliberation can be inserted back into the process of citizen-initiated referendums. In Switzerland, initiatives are subject to detailed parliamentary scrutiny before going to a popular vote, and parliament can make a counterproposal. In Oregon – as set out in our Doing Democracy Better report – a citizens' panel is often established early in the campaign period to examine the proposals. Alan particularly recommended a third option: a successful petition for an initiative should lead not directly to a public vote, but to a citizens' assembly. This would examine the proposal in detail and decide whether it should go to a popular vote or not.
You can watch Alan's presentation here from 11:32.
The evidence session was summarised by CBC, Canada's public broadcaster, here.


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Experts at the conference to announce early results of archaeological excavations of the Châu Thành tower remains in Bình Định. Photo courtesy of sggp.org.vn |
BÌNH ĐỊNH — Artefacts unearthed at the Châu Thành Tower ruins in Bình Định have helped archaeologists place the oldest date of these structures to between the 4th and 6th centuries.
The Department of Culture and Sports of Bình Định Province and the Việt Nam Institute of Archeology hosted a conference to announce the early results of archaeological excavations of the Châu Thành Tower remains in Nhơn Thành ward, An Nhơn town, Bình Định on August 18.
Phạm Văn Triệu, deputy head of the Historical Archeology Department at the Institute of Archeology, said the unit has uncovered three architectures of two distinct stages based on stratigraphy, building techniques, and construction materials.
Bricks, tiles, ornamental ceramic pieces, laterite, many statue fragments, porcelain, and small pieces of gold were also found, among many more antiques, architectural materials, and stoneware.
Scientists are researching a part of a Chăm statue discovered with ancient inscriptions. Photo courtesy of sggp.org.vn |
Triệu believes that the findings of the third phase continue to provide crucial information for verifying the official scale of the Châu Thành Tower and pinpointing the site of the main temple.
"Through the findings, it can be said that this ruins exists a large-scale tower architecture, and reflecting the entire historical period of the ancient Champa capital," he said.
The third excavation also helps identify the oldest date of the Châu Thành Tower remains in the 4th to 6th century.
Similar findings were discovered in ancient architectural works at Trà Kiệu Citadel (Quảng Nam), Cổ Lũy (Quảng Ngãi), and Hồ Citadel (Phú Yên).
They are evidence of the three-hundred-year era of territorial unification, which created a common nation.
Notably, the results of the excavations at Châu Thành demonstrate the early impact of Hindu culture on the spiritual lives of the Chăm people.
Lê Đình Phụng, of the Việt Nam Association of Archeology, said the remains of Châu Thành Tower are one of two large-scale ancient Chăm architectural works that shed light on historical evidence of the initial capital of the Lâm Ấp Kingdom in Bình Định.
Phụng added that this archaeology would contribute to the clarification of Bình Định's culture and history as well as Champa's historical culture after it has been merged into the Vietnamese cultural flow.
Huỳnh Văn Lợi, deputy director of the Provincial Department of Culture and Sports, praised the archaeological findings at the Châu Thành Tower.
The cultural sector of Bình Định plans to collaborate with the Institute of Archeology and scientists in order to continue investigating and clarifying the literary, historical, and religious significance of the Châu Thành Tower ruins. VNS


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You might notice that Manchester rats will be more active inside the house once the temperature drops. This is also the perfect chance for them to steal those oranges that are ripe for the picking. This will become a very busy for this tiny creature. Consequently, we will be also become very busy in looking for ways to keep them out of our property. Nonetheless, they don't really love the cold season. In fact, they will be invading our house during winter since they are looking for a warm place to escape the biting cold.
Why Rats Appear to be More Active During Cold Season?
In summer, there will be plenty of food sources for rats in the wild. There is absolutely no need for them to invade our house and expose themselves to humans. There are also different places to conceal their presence that will keep them safe from the predators. Therefore, summer is often the nesting season of most animals such as rats.
The Problems Related with Cold Season
Once the temperature drops, the times will be tougher for the animals. There will be very little food available for them in the wild. Therefore, most wild animal will go through a state of torpor. Unfortunately, rats don't hibernate, and they do not have any choice but to remain active. They will have to look for a new food source. The water source in the wild has been probably frozen. In order to receive their daily source of sustenance, they will rummage our trashcan.
Their shelter outdoors will also not be sufficient to keep them warm. It will be very difficult for the baby rats to survive if they remain outside. Therefore, most of them will be moving inside our house. Our house provides warmth, comfort, and easy access to food source.
How to Keep the Rats Away from Our House During Winter
The best way to keep your house protected from the invasion of rats is to ensure that it is properly sealed. The
Manchester rats can enter our house using a hole that is about the size of the nickel. You can use a hardware cloth, a steel plate, or a stucco mesh that you can purchase at the hardware supplies or construction material suppliers.
Start checking for the holes on the exterior of the house. Use a chalk to mark the holes to ensure that you will not miss them later. Cracks on the caulks, sinks, and vents are the possible location of access hole for them. The gaps on your windows and doors can also be used by the rats to enter the house.
In case the rats have already entered the house, then you must get rid of them. You can use exclusion device and traps. Be strategic and wise in the placement of traps. The bait can also affect the efficacy of your traps. If you are planning to use a live trap, check the traps regularly to ensure that the rats will not die from starvation.
Visit our Manchester wildlife removal home page to learn more about us.


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Delayed sedimentary response to abrupt climate change at the Paleocene-Eocene boundary, northern Spain
Show full item recordAbstract
Sediment routing systems (SRSs) are a critical element of the global response to ongoing climate change. However SRS response to climate forcing is complex, fragmentary, and obscured when viewed over short, human time scales (10 -1 -10 2 yr). Over long time scales ( > 10 2 -10 3 yr), the aggregated, system-wide response of SRSs to climate forcing can be gleaned with more confidence from the sedimentary record, but the nature and time scales of this aggregated response to abrupt climate change are still poorly understood. Here, we investigate the aggregated temporal response of a SRS in northern Spain to abrupt climate warming at the Paleocene-Eocene thermal maximum (PETM). Our results show that terrestrial sites in northern Spain record a temporal lag of 16.5 ± 7.5 k.y. between the onset of the PETM, defined by an abrupt negative excursion in the δ 13 C profile, and the onset of coarse-grained deposition. Within the same SRS at a deep marine site 500 km to the west, we observe a temporal lag of 16.5 ± 1.5 k.y. using an age model that is independent of that used for the terrestrial sites. These results suggest that the aggregated, system-wide response of SRSs to presentday global warming-if we take the PETM as an appropriate modern-day analogue-may persist for many millennia into the future.
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Having trouble finding what you need? Give us a call today! Please note: Local delivery is available. We do not offer shipping.
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Nollywood actress, Georgina Onuoha has reacted to the victory of the All Progressives Congress (APC) presidential candidate, Bola Tinubu, at the just concluded elections.
It was earlier reported that the Independent National Electoral Commission (INEC) in the early hours of Wednesday, March 1, declared Tinubu, as the president-elect.
The former Lagos State governor scored 8,805,420 votes to defeat his counterparts, Peter Obi of the Labour Party (LP) and Atiku Abubakar of the Peoples Democratic Party (PDP) in the tight race.
Taking to her Instagram page, Georgina shared a video compilation of how Tinubu reacted to his victory, stating he will never sit on the presidential throne.
The thespian cried out that Nigeria has been raped as a nation and has been denied justice and fairness.
She further described the presidential election as criminal and sham stressing that Tinubu is not her president.
Expressing displeasure over the action of INEC, Georgina said that the electoral body stole the people's mandate.
She wrote: "You will never sit on this throne Tinubu. Lord we've been raped as a nation and denied justice and fairness How? This is criminal… This is a sham NOT my President @inecnigeria you stole our mandate."


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This flagship event brings together various practitioners in the FinTech and digital money ecosystem including thought-leaders, academics, corporates, policy makers and the rising stars of the FinTech world.
Join us as we discuss the Future of Finance, Web3, Blockchain applications, Neobanks, AI in Finance, the Metaverse and its Future, Crypto regulations, CBDCs, Stablecoins, Regulated Liability Networks and much more!
To see the agenda click here.
To see the highlights video and see some related interviews click here.


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Locomotive Mechanic
Specializing in propulsion system conversion, refurbishment, repair and modernization of locomotives, passenger trains and freight cars, CAD Rail Industries is currently looking for a locomotive mechanic.
Roles and responsibilities
- Repair, recondition and rebuild diesel engines, water pumps, oil pumps and radiators;
- Install large components such as gearboxes, pumps, motors or hydraulic components;
- Adjust equipment and repair or replace defective parts, installations or components, using manual or mechanical tools;
- Test repaired equipment to ensure that it is functioning properly and that repairs are in accordance with customer requirements;
- Perform other routine maintenance work;
- Maintain accessories and work tools;
- Move and align sub-assemblies and components using lifting and transport equipment, including overhead cranes;
- Check the quality of the work.
Job requirements
- Hold a DEP in industrial mechanics / diesel or DEP heavy vehicle;
- Professional experience with heavy vehicles / Diesel;
- Professional experience on locomotives would be an asset;
- Experience with precision instruments (micrometer, vernier, etc.);
Skills and competences
- Ability to read blueprints and perform basic calculations;
- Manual skills for mechanics;
- Ability to work in a team and independently;
- Be willing to learn and develop skills;
- Be able to read procedures in English;
- Be in good physical condition and be prepared to work in difficult conditions: heat and cold, noise, dust, odors, confined spaces and in heights;
- Be flexible about the tasks to be accomplished;
- Ability to stand up and lift moderately heavy loads;
- Be available to work various shifts (day or evening);
- Have a functional level in English (spoken and read).
The masculine generic is used in this text only for the purpose of lightening the form and making it easier to read.


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BHN Puck Links
BHN Puck Links: Boston Bruins' Foligno Talks Leafs Back Injury
The Boston Bruins have to hope that 33-year-old Nick Foligno can avoid the kind of injury that sapped his effectiveness down the stretch last season after being acquired by the Maple Leafs at the trade deadline. The hard-nosed, intense Foligno suffered a back injury just a handful of games into his stint with the Leafs last spring and that impacted him the rest of the way through the season, including dressing for just four of the seven playoff games against the Montreal Canadiens in the first round of the Stanley Cup playoffs.
"I was just dealing with a really bad back injury that was debilitating," said Foligno to "Good Show" earlier this week. "There was nerve pain. Shut down my whole right leg. It was really disappointing that happened at the time it happened. Anything else you can play through a lot of times. This I couldn't. I tried and I just couldn't be the player — I like to hit and forecheck and do the things necessary in order to win the hard minutes of the game.
"So when that kind of got taken away now I had to rely more on my positional play and trying not to hurt the team, instead of trying to help the team it felt like. That bothered me a lot as a player just because I knew I could give more, I just physically couldn't."
Now Foligno is 100 percent healthy after a long offseason following Toronto's first round exit in the playoffs and won't be expected to carry a heavy load with newfound depth and the Perfection Line taking center stage for the Black and Gold. Instead Foligno will be counted on for leadership, sandpaper, tough interior play around the net and the occasional goal as a veteran third line player that's been a 31-goal scorer at the NHL level previously in his career.
"I'm looking forward to building relationships with all these guys and showing them that I'm here to push the same direction as everybody else. How bad did I want it? My work ethic. I think all those things, you have to build the trust of a team before you can act like a leader," said Foligno, at his introductory zoom call with the Boston Bruins media. "That's something that I enjoy. I enjoy building relationships so guys can trust you and know that you're in the trenches with them. I look forward to doing that with this group. I like that part of the game. It's something that I feel like I thrive in, is having that voice or that work ethic and lead by example.
"Listen, there is no shortage of leaders on that hockey club. It's a reason why I joined. I wanted to learn from a guy like Patrice and Marchy and the list goes on of that team. I'm looking forward to being around those guys and absorbing what they do and the recipe for having success they've had. And try to add to it and also take some stuff in my game and try to help the team even more."
Provided Foligno can stay relatively healthy as he approaches his NHL middle age years, everything else should fall into place for a veteran guy that's going to be a natural fit with the Bruins.
*The NHL sent out on Thursday their COVID protocols for the 2021-22 NHL season that will pretty harshly deal with unvaccinated players, and amazingly Boston Bruins D-man Connor Clifton sent out a message on social media that he contracted COVID on his honeymoon. Wishing the best for him for both his health and navigating an angry wife that wasn't looking for this during the honeymoon. (Boston Hockey Now)
*With NHL players headed to the Olympics George Richards takes a look at which Florida Panthers might be headed to Beijing for the Winter Games. (Florida Hockey Now)
*Similarly, Dan Kingerski takes a look at Mike Sullivan and his coaching staff for Team USA as they get ready for the Olympics. (Pittsburgh Hockey Now)
*FOH (Friend of Haggs) Kirk Luedeke ranks the top prospects at the defensemen and goaltending positions for the Boston Bruins. (New England Hockey Journal)
*I know this isn't Jaromir Jagr, but I really, really, really wish this was Jaromir Jagr with an amazing story to tell when he finally finished skating.
I never want to know the context of this video. I just want to appreciate it. pic.twitter.com/tMFG5aJSTL
— Nick Palmisciano (@Ranger_Up) September 3, 2021
*In case you've missed it, we're hiring writers in a number of different NHL markets at National Hockey Now. So check it out!
I guess I should post this stuff on Indeed, but we're moving quickly:
National Hockey Now is hiring beat writers for Toronto, Montreal, Edmonton and Las Vegas.
Salary. Generous bonuses. Should already live there. Snappy uniforms not included. pic.twitter.com/JtmmFIdPfy
— Dan Kingerski (@TheDanKingerski) September 3, 2021
*Tim Horton's raised over $200,000 for the Hockey is Hers campaign with a Hockey Barbie campaign. That is pretty awesome. (Tim Hortons)
*The Anaheim Ducks could be worth watching in this trade market as a team with some interesting names part with. Ryan Getzlaf could be a difference-maker for a playoff hopeful at the NHL trade deadline. (SI.com)
*For something completely different: Tom Brady is awarded the TKO for crushing Mike Vrabel with this harsh, merciless trash talk.
TB12 just won the war of words by TKO https://t.co/DVSKcQL8Pu
— Joe Haggerty (@HackswithHaggs) September 2, 2021https://platform.twitter.com/widgets.js


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I have an ATV2 running 5.2.1 TETHERED JB and just saw the news about 5.3 untethered JB and I'm of course quite interested in this upgrade. I'm using a MacBook Pro running Mavericks.
I haven't managed to upgrade though. I try to follow to the guide, but when it tells me to connect my ATV2 and I connect it, it tells me it couldn't find any connected ATV2
What am I doing wrong?


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Tv presenter Eamonn Holmes returned to ITV's This Morning to offer moral support to his wife and co-presenter Ruth Langsford following the death of agony aunt Denise Robertson.
The pair led tributes to the 83-year-old ITV legend who sadly passed away this morning following a short battle with pancreatic cancer.
Eamon returned to the morning programme for the first time since his double hip replacement. He announced the tragic news on air saying: "Our beloved Denise Robertson has lost her battle with cancer", while Ruth added "it's a difficult day for us."
Denise joined the show ten years ago and has been popular with fans ever since. She announced in February that she had gotten a shock diagnosis of cancer, and would be undergoing treatment for it. In a statement read out on This morning Denise thanked fans, and hoped that to return to the This Morning sofa again soon.
"I'd like to thank all the lovely viewers of This Morning who have been concerned about my health recently and I hope I'll be back on the sofa soon."
Sadly, this was not to be the case. Denise is survived by her husband and only son. May she Rest in Peace.


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The Athens Twilight Criterium
The Athens Twilight
The Athens Twilight Criterium is, by consensus, the fastest one-hour of bicycle racing on this planet. The speed is insane and is a direct result of the course—it's a 1-kilometer rectangle that riders can whip around without braking, even through the corners. If a rider even feathers the brakes, he's (she's) losing ground. The Twilight is an opportunity for a rider to slap his chain onto the big ring, open the throttle, and flat-out haul arse. The insane speed is also a direct result of the racers—these are the adrenaline junkies, the ones with the need for speed, the fastest guys and gals in the world over the course of an hour. These lunatics can lean their bikes, and their bodies, around this 1-kilometer rectangle at precarious angles and ludicrous speeds that defy Sir Isaac's general principles, and maybe one or two of Moses's ten tenets. Going this fast must be a sin, but if you think this race is all fun and games, think again.
One sees them before the race—glabrous and glistening, heavily oiled, gliding peacefully on their bikes through the parking lot. They're wearing a tan fit for a country club patron. They look cool, calm, relaxed, like a veteran trial attorney stepping into the courtroom. But look close—inside they're falling to pieces, they're coming undone. If you took their shirts off, you'd see—their brittle torso is white like cotton, the tan's a façade. They may be smiling now, but Conway and Loretta would say, "its only make believe" because the Twilight averages over 30 miles-per-hour for over one hour; this is no joking matter. Does a condemned man rejoice in the moments before placing his back to the wall and his chest towards the muzzles of a dozen pointing rifles?—it's absurd to think so. These are disco sprinters (vainglorious fools) that think getting dropped in this race in front of everyone is a fate worse than death. These moments of dread and despair before the race feel like little rats chewing the inside of one's stomach and in these worrisome moments, many riders realize that they, like Union Army Privateer Henry Fleming, might fling the rifle and head for the hills in a moment of impending catastrophe: Their red badge of courage, a poop stain in their pants.
When a racer is standing at the starting line, he/she (gender neutral throughout) does his best impression of a relaxed rider, but relaxing when thousands are staring laser-guided missiles through you ain't easy. And, it's too noisy to concentrate—this inebriated, goodtime, Rabelaisian crowd is cackling like a henhouse full of lusty roosters, making a rider's heart beat against his chest like a sledgehammer pounding on a thin tin roof. A couple hundred corralled cyclists are bobbing and bouncing like a field full of insanatics, waiting for the gate to fall so they can escape from the asylum. The riders on the front row don't dare look back—they don't want the riders behind to see the terror raging in their eyes. Their common fear?—they might be trampled to death.
When the gun finally fires to start the race, a rider sprints to the first corner as if his life depended on it, and it might. It's the maddest dash of the entire race, so far—the dash to the first turn. If a rider makes it to the turn near the front, he can hit the throttle and floor it out of the corner and accelerate down the road with no obstructions, clear sailing. If he gets to that first corner too late, it's like a bucket of sand poured into a small funnel—it just takes a little time to get all the grains through. The point: If a racer comes out of the first turn too far back, in the Twilight, the race is over and it's only ten seconds old: Finis, Finito, Good Night Irene.
In order to survive sixty laps (now 80), the total distance of this race, a rider must get through the first lap unscathed and well placed and not too far back from the front. Generally, only fifty or so will finish because the rear of the field is like the tail of a whip. The unfortunate souls at the wrong end of the line are getting whipped and tossed about like a fly in a tornado. If a rider can't hold the wheel directly in front—that is, keep his front wheel about six inches from the forward rider's rear wheel, sometimes while traveling at speeds topping forty miles per hour—his night won't last long, it is impossible to bridge gaps in this race. If a rider allows a gap to open, he and everyone behind him will be out this race in a matter of seconds, it is a modern day example of Darwinism: To survive one must keep-up with the herd; become separated, and the vultures will soon feast. A racer must focus on the ass-crack in front of him and hold on for his honey's life.
During the first ten laps, a rider's pain meter is stuck at the far right end of the red zone. He is feeling the scalding acid of lactic burn in his legs caused by excessive speed as the fastest riders in the world uncork the top-shelf high-octane. The disco sprinters and their teams know in the first ten laps they can cause an explosion in the field as over half the field is dropped, quits or crashes. These skilled assassins, want to dump as many riders as possible now, leaving fewer to contend with later.
In most criteriums, if a rider survives the first ten laps, he knows he will survive until the end. In most criteriums, after the initial frantic, escape from prison free-for-all, there is an ever-so slight decrease in speed, and a small incremental drop in speed can do wonders for a rider's ability to recover his runaway breath. But the Twilight is not like "most" criteriums. In fact, it's most unusual: The speed does not drop, it is relentless, it is like trying to play chess while your heart rate is a constant two hundred beats per minute.
But these two-wheeled assassins are also magicians, they've been outwitting pain for years. Pain, they know, has no brain, so they trick pain, they confuse pain, they endure pain, like a visit from a mother-in-law, anything to hang in, to finish, and maybe, who knows? And just when they think everything is under control, the race becomes faster: A rider is pedaling a constant thirty-seven miles per hour and is at his limit. He looks up the road and sees a group of four riding away.
If a rider can hang on and hold out for half the race, something happens. The demon of self-doubt is put to sleep and confidence begins its slow drip into the veins. One doesn't need to see a rider's face to know, look at the way he handles his bike. A rider with confidence does not ride with his fingers over the brake levers, he's down in the drops, gripping the bars, he's sailing through turn one in a perfect arc, coming out of the corner in front of the Georgia Theatre cruising comfortably two inches from the curb, intentionally coming within centimeters of the heads in front of the Georgia Theatre that are stretched out over the barricade--they pull back like a line of Rockettes as he passes.. He's loose and locked in, he's floating on his pedals, he's entered the Zen-zone, this is special.
If a rider makes it to the end, there is another factor to consider: Pro teams are expected to win. This is no longer about sportsmanship and fair play, if it ever was. Riders bump and grind and jostle for position, various invectives are hurled, psychological tactics are employed. The best sprinters in the world play a terrifying game of chicken—Back off or bite the curb. Riders may be downing a cold beer together afterwards but at this point in the race, this is a job, this is a paycheck, this is prize money, this is winning. This, brothers and sisters, is living, and the only thing in the world that matters is this moment.
The last two or three laps of this race are spectacular. The big teams are amping-up the speed as high as it can be humanly maintained. The reason: It's impossible for a rider to move up if he's already pedaling at his limit. The disco sprinter on the team is sitting fourth, fifth, or sixth wheel with two laps to go but out of the last corner has moved to second, third or fourth wheel—these are the spots the winner will come from. The last two hundred meters is simply a stripped-bare example of sheer speed as racers try and tear their bikes apart at the seams as they pull and jerk and twist and pedal in a violent display inner angst. They cross the line, it's all over, all smiles, that was the greatest race they've ever done, they can't wait to do it again. Have you ever watched film of mountaineers climbing Everest? They're miserable, some even die. Have you heard them speak of their experiences after they return? They can't wait to go back. It must be a disease.
David Crowe


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Elephant tramples man to death in Sherpur
A 48-year-old man was trampled to death by an elephant in the Panihata Mission area of Sherpur's Nalitabari upazila in the small hours of Friday, reports UNB.
The deceased was identified as Opu Marak, who belonged to the indigenous Garo community.
According to witnesses, a herd of 20-25 wild elephants came down the hills of the neighbouring Indian state of Meghalaya and barged into the fields of local farmers around 12.15am.
The farmers were guarding their fields in view of the harvest season. And while chasing away the elephants, Opu was trampled to death by one of them, said the locals.
Officer-in-charge of Nalitabari police station Bachir Ahmed Badal said that a police have been sent to the spot.


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4Methods You should use Astrology To Become Irresistible To Clients
SIC integrates HYTA (classifies images based on their NRBR) with CSIT technique (which uses GHI time collection to detect the kind of sky image). Cloud classification is utilized additional to classify each picture occasion in several cloud situation classes for evaluating forecast efficiency under different cloud situations. Assigned to completely different classes of cloud varieties. It's onerous to say the longer term what sorts of new options inside our cell phones may have. ARG in detecting seven cloud varieties accurately. Using common values for each of the 12 cloud classifications doesn't provide the optimum outcome, since clouds of one class might range significantly due to the metrics used for classification. They could have discovered a mentor who guided them in their life path. He had a love for all different life and tried to protect it when he may, however his programming would not enable him to disregard his pursuit of Earth's greatest hero. Classify them in case subimages embody enough info to assign image parts to a cloud class. The results indicate that the sky imager retrieval for distances of greater than 1-2km from the digicam under cumulus cloud conditions outperforms a single pyranometer measurement. Related error exists between cumulus and excessive cumulus on account of similarity of their color and smooth transition in definition.
ARG. The remaining pictures correspond to the times with appreciable excessive values of aerosol optical depth (AOD), an optical parameter which is not thought-about in the classification algorithm. For figuring out parameter s and CSI threshold, a set of training samples is created using completely different sky patterns. The AM wants a Uncooked picture, the spectral response functions in RGB channels, parameter s, threshold of CSI for cloud discrimination, ozone column amount, and solar zenith angles (SZAs). The number of options utilized for cloud classification algorithm embrace three further options as compared to those utilized in previous work. To beat this problem, subclasses of each cloud class are created on the premise of extra options (solar zenith angle, cloud protection, the seen fraction of solar disk) used in the work, which affect tremendously the distribution of mild in sky. Along with statistical colour and textural features, solar zenith angle, the cloud coverage, the visible fraction of photo voltaic disk and the existence of raindrops in sky photos are additionally thought of. The main focus is to investigate the efficiency of the forecasting model under completely different cloud situations.
First is concerning the accuracy of sky-imager-based mostly analysis underneath totally different cloud circumstances with respect to the space from the digicam and secondly its accuracy when in contrast with a persistence mannequin. In the following we focus on cloud movement. On this work, we concentrate on the ACS MIR instrument (Trokhimovskiy et al., 2015), which observes Mars purely via solar occultation viewing geometry with the line of sight parallel to the floor, acquiring a set of transmission spectra of the Martian atmosphere at individual tangent heights separated at approximately 2 km intervals from effectively under the surface of Mars up to the top of the environment during a single measurement sequence. Due to this fact we used as a substitute a set of floor-based mostly reflectance spectra of the lunar floor accessible via the PDS Geoscience Node††http://pds-geosciences.wustl.edu/missions/lunarspec/. The interval limits are estimated from training set. As soon as the threshold is determined, pixels with larger R/B values than the threshold are marked as cloudy. R/B ratio and may impression the efficiency of cloud classification algorithms. Schmidt et al. use the steps for sky picture analysis and irradiance forecast shown in Determine 4. A modified R/B for every pixel at the picture position is proposed to overcome misclassification of circumsolar area.
FTM is based on the truth that the cloud pixels (in RGB image) have larger crimson (R) depth values than sky pixels. Training the cloud classifier. At his urging, she gained permission to hitch whites-solely lessons and enrolled in a coaching program that earned her a promotion from mathematician to engineer. The opposite method is a simplified technique (SM) that makes use of digital alerts in JPEG image format. SACI uses fastened threshold technique (FTM) for overcast pictures, clear sky library (CSL) and FTM for clear pictures, CSL and minimal cross entropy (MCE) for partly cloudy photos. One methodology is a sophisticated method (AM) that uses Uncooked digital image format. Dark clouds attributable to making use of world threshold to the picture. Applying optical move algorithm results in cloud movement vectors (CMVs). The cloud movement is obtained by applying optical flow algorithm obtainable in open supply computer vision (OpenCV) to the unique greyscale picture, where the artificial objects are masked out. The cloud detection scheme considers binary states (sky/cloud). Bearing in mind the importance of aerosols variations within the cloud detection and classification, Ghonima et al. In cloud mapping step 3D position of cloudy pixel is decided using cloud base peak obtained from ceilometer.


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