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- VirtueMart extensions
Paid download
Mod OS Virtuemart Slideshow
By OSTheme Team!
VirtueMart extensions
Run multiple Virtuemart product slideshows on a single page, display latest or featured products by category, exclude products on out of stock, customize captions area, selectable cool styles, there are three styles for you choose now, and much much more options via module parameters. Now, running product slideshows on the web is a breeze. Compatible with any combination of: Joomla 2.5, joomla 3...
Paid download
Datatrans Virtuemart Payment
By Masterhomepage
VirtueMart extensions
Datatrans is the specialist for Internet payments with activities in Switzerland as well as abroad. As the market leading Swiss payment service provider (PSP) Datatrans operates independently from a financial institution and - as a consequence - exclusively in the interests of e-tailers. Logos ZM Datatrans supports all major credit cards and other means of payment as well as credit assessments f...
Paid download
VM Buy UserPoints for Virtuemart
By Nordmograph
VirtueMart extensions
This plugin allows you to sell user points (AlphaUserPoints , EasySocial or Jomsocial Points ) in Virtuemart and automatically deliver purchased points to Virtuemart Customers. Administrator must create a Virtuemart category dedicated for points packages, then create points package products taking the points-currency ration in considaration when setting the price. For example if you have a ration...
Paid download
OS Virtuemart slideshow
By OSTheme Team!
VirtueMart extensions
Run multiple Virtuemart product slideshows on a single page, display latest or featured products by category, exclude products on out of stock, customize captions area, selectable cool animation effects, and much much more options via module parameters. The module allow to use the wheelup and wheeldown to previous|next item in the list. Compatibility with Joomla 2.5, Joomla 3 + Virtuemart 2, Vir...
PayU Poland for VirtueMart
By Claudiu Maftei
VirtueMart extensions
PayU Poland for VirtueMart Plugin is a VirtueMart payment plugin for PayU Poland payment gateway. -Link Virtuemart with PayU Poland -Take payments online -Compatible with Virtuemart 2 and 3 (VM2/VM3) -Easy to configure and install -Payment Tax -Cost Per Transaction -Payment Percentage Fee -One year support and updates...
Paid download
Samport for Virtuemart
By GJC Web Design
VirtueMart extensions
This is the VirtueMart 2.0 Samport Payment Plugin to connect to the the Samport payment gateway at checkout. Samport is one of the most popular suppliers of payment solutions and terminal products throughout the Scandinavian region. This plugin connects you to their Hosted E-commerce solution. Once you have applied for a merchant Account from Samport you will have access to their WebManager wher...
Paid download
JO VM Auto Twitter for Virtuemart
By Joomcore
VirtueMart extensions
JO Virtuemart Auto Twitter is a simple but powerful extension for Joomla and virtuemart, that automatically tweets your new product to your Twitter page With our plugin, you don't need to go to Twitter website to update your messages, all thing you need to do is create products on your site then plugin will automatically tweet your product title, price along with a short link. This way all your T...
Subscribe Buyers to AcyMailing for VirtueMart
By Open Tools
VirtueMart extensions
Virtuemart plugin to automatically subscribe buyers to certain AcyMailing Lists, and to allow subscription to notifications on the product page. With this VirtueMart plugin, all buyers of a product can be automatically added to an AcyMailing list upon purchase. Additionally (or alternatively), a "Subscribe" and "Unsubscribe" button can be shown on the product page to allow manual subscription an...
Paid download
OS Slide For Virtuemart
By OSTheme Team!
VirtueMart extensions
Run multiple Virtuemart product slide on a single page, display latest or featured products by category, exclude products on out of stock, customize captions area, selectable cool styles, there are three styles for you choose now, and much much more options via module parameters. Now, running product slideshows on the web is a breeze. Compatible with any combination of: Joomla 2.5, Joomla 3 and...
Akatua Gateway
By Issah Issifu
VirtueMart extensions
Akatua is Ghana's most reliable payment gateway that allows users to make secure and convenient online payments using their regular bank accounts, and mobile money wallets. Akatua allows users to make instant payment for goods and services online without revealing any payment details, thereby reducing the risks usually associated with online shopping to the lowest degree. Online merchants can also...
Paid download
Bulk order print for virtuemart
By VirtuemartExtended
VirtueMart extensions
Bulk order print is a simple and elegant plugin for printing orders in virtuemart system, it has no CORE HACKS, and forward & backward compatible....
Paid download
Sells Counter for Virtuemart Products
By Nordmograph
VirtueMart extensions
Shows a sells counter on Virtuemart product details page. Make sure 'Joomla plugins' are enabled in Virtuemart configuration page. Settings let admin choose between displaying the counter at the beginning or the end of product description. It's also possible to choose the order item status to take into consideration for the count (confirmed , pending, shipped etc...) It's possible to show with the...
PayU for VirtueMart
By Claudiu Maftei
VirtueMart extensions
PayU VirtueMart Plugin is a VirtueMart payment plugin for PayU Romania and LATAM (Latin America: Argentina, Brasil, Chile, Columbia, Mexico, Panama, Peru) payment gateway. -Link Virtuemart with PayU -Test and Live modes -Take payments online -Compatible with Virtuemart 2 and 3 (VM2/VM3) -Easy to configure and install -Payment Tax -Cost Per Transaction -Payment Percentage Fee -One year support and...
Paid download
CSV Currency For VirtueMart
By MGS Creativa
VirtueMart extensions
CSV currency plugin for VirtueMart This currency plugin for VirtueMart uses a manually generated CSV file by the store administrator. This plugin supports a wide range of world currencies manually loaded through a CSV file which is stored in the Joomla! cache directory. The plugin can be easily configured to fit your needs. This plugin works even at the moment of choosing the payment method in t...
Paid download
Redsys payment gateway TPV for Virtuemart
By Ayuda Joomla
VirtueMart extensions
Receive online payments with credit cards in Virtuemart 2 / 3using Redsys (Servired – Sermepa) payment gateway. What is included in this Redsys payment gateway for Virtuemart 2 / 3? Compatible plugin with Joomla 2.5 / 3 and Virtuemart 2 / 3. It's really easy to install and configure your payment gateway in your store. Ebook with detailed documentation (text + images) about the installation...
Paid download
SJ Matrix Slider for VirtueMart
By SmartAddons
VirtueMart extensions
SJ Matrix Slider for VirtueMart is a great module that has been released. This module is a perfect solution to help your hottest products are presented with many types of effect. It is designed full width slideshow, the same background for all slides along with jQuery easing which can make your animations look a lot better, you can place module right on home page or any positions. Especially, thi...
Paid download
Order Discount Rules for Virtuemart
By Glimlag.gr
VirtueMart extensions
If you are searching for an extension to make direct cart discounts depending on the order total, then this extension is for you. Order Discount Rules for Virtuemart applies discount on cart depending on the order subtotal or subtotal without tax (you can select what is the best for you). Up to 5 (five) discount rules. Amount or percentage discount. Instant installation and use Really easy to...
Paid download
By eKerner · technical developer
VirtueMart extensions
VM API !MULTI! v1.3 by ekerner.com Allow others to display and promote your Virtuemart products on their websites. Features ... Supports Virtuemart Products, Categories, and Manufacturers. Works for any GET request like cURL, AJAX, file_get_contents(), etc. Responses in HTML or JSON. Products by category, vendor, popularity, featured, latest, random, recent. Product limits configurable. HTML lay...
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Seven to ten years. That's how long someone diagnosed with multiple system atrophy (MSA) has to live from when symptoms first appear. The progressive disease results in the gradual functional decline of the body's involuntary functions such as blood pressure, breathing, bladder function and motor control.
Often confused with Parkinson's which is characterised by the progressive degradation of nerves that control movement, MSA affects the autonomic nervous system.
There is currently no evidence that MSA is genetic or caused by environmental factors, meaning this 'sporadic' rare disease can affect anyone.
With no specific treatment for MSA, doctors are resigned to managing symptoms to varying degrees of success. Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) is developing a novel medication named ATH434 to reduce toxic levels of alpha-synuclein, a neuronal protein responsible for certain nerve cell functions. Alpha-synuclein accumulation is a pathological characteristic of MSA and plays a role in destruction of nerve cells. In theory, reducing accumulation of the protein in the brain will preserve function in patients.
The Drug has been granted Orphan Drug designation by the US Food and Drug Administration (FDA) and the European Commission (EC), and recently passed Phase 1 safety trials.
The Company is now furthering their work on ATH434, initiating a Phase 2 clinical trial for treatment of early stage MSA patients with enrolment now open in New Zealand. The randomised, double-blind and placebo controlled trial will evaluate the effect of the medication on protein levels in the brain and motor control in 60 patients. Patients will wear sensors that allow researchers to gather data on motor parameters. The trial will also further inform on the safety and pharmacokinetics of the drug.
ATH434 has potential applications in Parkinson's Disease and other types of atypical parkinsonism as it inhibits the build up of proteins that cause neurodegeneration. With over 1 million people suffering from Parkinson's in the US alone the treatment market is expected to exceed USD $11.5 billion by 2029- somewhat taking the sting out of having just one pipeline asset.
For the March quarter, Alterity reported a cash balance of $32 million
- Parkinson's UK backs Pharmaxis with $5 million to slow the onset of incurable disease with 'ground breaking' trial - September 1, 2022
- How this company is developing medtech to support Indigenous community health - August 22, 2022
- A round of ap-paws for PharmAust, changing the ruff prognosis for dogs with lymphoma - August 17, 2022

subset: commoncrawl


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CLR SqlShell Malware Targets MS SQL Server for Crypto Mining and Ransomware
Poorly managed Microsoft SQL (MS SQL) servers are the target of a new campaign designed to spread a category of malware called CLR SqlShell which ultimately facilitates the spread of cryptocurrency miners and ransomware.
"Similar to a web shell, which can be installed on a web server, SqlShell is a type of malware that supports various features after being installed on an MS SQL server, such as executing commands from threat actors and performing all kinds of malicious behavior," AhnLab Security Emergency Response Center (ASEC) said in a report published last week.
Stored procedures are subroutines that contain a set of Structured Query Language (SQL) statements for use in various programs in a relational database management system (RDBMS).
CLR (short for common language runtime) stored procedure – available in SQL Server 2005 and later – see stored procedure written in a .NET language such as C# or Visual Basic.
The attack method discovered by a South Korean cybersecurity company requires the use of CLR stored procedures Install malware on the MS SQL server using xp_cmdshell command, which invokes the Windows command shell and passes instructions as input for execution.
Some of the techniques used by threat actors, including those related to Lemon Duck, my king (aka DarkCloud or Smominru), and fully ripeconcerns the exploitation of an Internet-exposed MS SQL server through brute-force and dictionary attacks to execute xp_cmdshell commands and OLE stored procedures and run malware.
The use of CLR stored procedures is the latest addition to this list, with attackers leveraging SqlShell routines to download later-stage payloads such as Metasploit and cryptocurrency miners such as MrbMiner, MyKings, and LoveMiner.
Learn How to Stop Ransomware with Real-Time Protection
Join our webinar and learn how to stop ransomware attacks in their tracks with real-time MFA and service account protection.
What's more, SqlShells named SqlHelper, CLRSQL, and CLR_module have been used by different adversaries to elevate privileges on compromised servers and launch ransomware, proxywareand incorporates the ability to conduct reconnaissance efforts on targeted networks.
"SqlShell can install additional malware such as backdoors, coin miners, and proxywareor it can execute malicious commands received from threat actors in a manner similar to WebShell," ASEC said.


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Read below to see where I stand on important issues for Michigan.
Age Gap Improvement
I believe that Americans have a responsibility to take care of their communities. Especially the most vulnerable members. In order to do that we have to bring its citizens together. I want to bridge the gap of understanding between the age groups. I spend time with my older family members and friends who believe that young people do not show or offer respect to their elders. The younger people I talk to often express that people older than them do not understand their generation and feel left out of societal issues that are important, like government, and human rights.
I want to get involved with more programs that are willing to bridge the gap of understanding between the citizens of all age groups. I want to bring back the times when kids and teenagers offer to help with yard work and assisting of the local elderly. When I was a child, my brother and I would oftenled in Assisted Living facilities at Christmas time. We would help our family take care of animals or scooping hay on farms. We did what was asked and what was ne rake yards with our class, girl/boy scouts, or for our family members. We caroeded, and our family is still close to this day.
Unfortunately, I think we have lost those respect values when it comes to taking care of family and our elderly. I want to bring that back.
We can use school tutoring, skills teaching, nursing home volunteering, the institution on aging, Community gardens, field trips, cooking classes, meetup programs, and more to educate and connect the different groups within our areas. It is a valuable way to increase understanding between humans and their needs. I want it to be cool to be helpful and go give your time to people without expecting anything back. Our society puts a higher value on money than on helping out in our own communities and even within our own families. We can do better. We MUST do better. We owe it to ourselves as Americans.
I believe that FREE public education for all ages is not only the right thing to do, it is also necessary for the advancement as a country as a whole. The more informed and educated we are as a group, the more we can do to improve every aspect of life. We will have better medicine, better schooling for our kids, and a healthier way of living. For example, literacy rates of prisoners makes a good case for free education of all. If we are able to continue the education of young people through early adulthood it is possible we can lower the rate of ignorance and increase the ability of people to earn a decent
wage in a better job and keep them out of the prison system. Better education means a better life for all.
Another important personal issue I believe in is the education we give to our youth about credit and finances. We need to instill in our youth a respect and understanding of how important credit is, increasing credit scores, savings accounts, investing, and retirement.
I myself have struggled with learning about finances because nobody ever talked to me about it when I was young. I had to learn the hard way, and I want to help others avoid mistakes that others have dealt with.
Let's raise the quality of our systems, together.
"Results have very little to do with the goals you set and nearly everything to do with the systems you follow. You do not rise to the level of your goals. You fall to the level of your systems."
-Susan Cain
Family Values & Healthcare
I think that Citizens of the United States of American have the rights to their own bodies. I don't believe that women should have to share personal information or have to seek government approval to make decisions about their bodies. I believe that is a personal issue between a woman and her doctor. That applies to men's healthcare as well as the right of parents to decide what is best for their children.
Health Care is a human right and must be accessible to every citizen of this country. Nobody should die because of their access to insurance.
I have personally witnessed elderly citizens fighting for cancer coverage and not get medical help for it right away because they didn't have affordable insurance. We can do better than that for our people, for our grandparents.


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WWE NXT Resuming House Shows
They will be NXT's first house shows since the start of the pandemic
WWE NXT are going back on the road for the first time in over two years.
It was announced during last night's show that the third brand will stage eight non-televised events in Florida.
The shows will run from June 10 to July 23, with tickets going on sale this Friday.
Per the announcement, the dates and locations are:
- June 10 at the University Arena Community Complex in Tampa, Florida
- June 11 at the Largo Events Center in Largo, Florida
- June 24 at the Jacksonville Armory in Jacksonville, Florida
- June 25 at the Venice Community Center in Venice, Florida
- July 8 at the Citrus Springs Community Center in Dunnellon, Florida
- July 9 at the Englewood Neighborhood Center in Orlando, Florida
- July 22 at the Melbourne Auditorium in Melbourne, Florida
- July 23 at the Cocoa Armory in Cocoa Beach, Florida
NXT have not run any house shows since the onset of the COVID-19 pandemic in early 2020.
Prior to the pandemic, NXT ran non-televised events in Florida, as well as other select states and in international markets like the United Kingdom and Japan.
WWE.com noted that more NXT live event dates are forthcoming.


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A question I've started asking people when getting to know them is this: What do you do creatively?
I like the question for the broad scope it encompasses. So far, I've gotten answers about ways that might seem most obvious or common by sharing that they write, draw, knit, or do photography. I love finding out these kinds of things about others.
About a year and a half or so ago, I asked this question of one of the custodians I work with at my elementary school. He told me he was a cartoonist! A cartoonist who works at an elementary school. My eyes lit up. I asked if he had any of his work he could show me. Out came his phone and what fun to see this side of him! I told him students and staff would enjoy seeing his stuff and maybe he could post a couple on the door to the custodians' office?
"You think so?"
I tried to not be aggressively encouraging, but still, I said, "Absolutely! The kids especially would love it."
"Yeah," he said. "I haven't thought about that. Maybe I will."
But then he didn't. Which, you know, was totally okay. Sharing your creations of any sort can be really hard! Vulnerability lives there. But we talked a lot about our creative outlets.
"Did you do some writing this weekend?" he'd ask.
"I did! It's going well! What about you?" I'd reply.
"I spent some time doodling some ideas. I've been spending a little more time with it."
At least one other time I mentioned showcasing his work. "Yeah, maybe I'll put something up."
About a month ago, I visited a classroom for some kind of tech repair/investigation and saw this on the whiteboard:
I was so happy. And naturally, I found out later that the kids, of course, loved coming in the morning to see what he might have created for them.
A couple of weeks ago he left this note on my desk:
As I finish packing up my office for the summer this week, I plan on leaving my whiteboard markers behind and maybe he'll leave a creation for me to find next August.
QOTW: What do you do creatively? I'd love to know…and if you are willing to share an artifact, I'd love to showcase your creativity in my next newsletter. Alternatively, what is a fun creative side you've learned about someone? I'd love to hear that story, too!
Did you see the cover for my new book, yet? (I mean, if you were subscribed to my newsletter before now, obviously you did, but whatev.)
Pre-order details will be available super soon! If you follow me on Facebook, Instagram, or even Twitter, I'll be posting there first, but I expect next month's newsletter will also have the info.
In the meantime, I have two asks:
Are you someone who posts reviews in Goodreads, Amazon, Bookbub, or elsewhere? If so, perhaps you'd like to request an e-ARC of As Though You Were Mine? Let me know using this linked form.
Have you or anyone else listened to the audiobook of All I'm Asking? If you have–or know someone else who has–perhaps you can leave a one-line review/rating with Audible or wherever you listened to the ebook? I might not directly ask, only, it's not just for me. The narrator for that book did an amazing job (especially with a potentially challenging format) and I would love for her to get the kudos!
This is usually where I give you a couple of specific book recommendations, but I'm deviating a little bit from it this month. Not because I don't have recommendations (I always have recommendations), but I really want to showcase a couple of different things.
MEGA giveaway of books that mostly fit within the book club genre–including my debut, ALL I'M ASKING. And when I say "mega", I'm not really exaggerating. You can enter to win ALL 49 books plus an ereader! What are you waiting for? Click and enter!
Earlier this month was Women's Fiction Day and I joined up with several other amazing authors to help showcase our books. Some of us have offered samplers, some are still doing a giveaway, still others might have their books on super-sale or available for free.
Next month, I'll be back to my traditional book rec format. In the meantime, I'd love to direct you to author Kathryn Dodson's site where you can sign up for her newsletter. It's one I enjoy reading every month for her entertaining personal stories, many which involve her various travels. While you're there, you can download her free prequel novella in anticipation for her debut release, Tequila Midnight, on July 13th.
Ever grateful for the little things, but also the big things, including all of you.
I loved, loved the relationships in this novel, particularly the central friendship. --Amazon Review
1078 Seminole Ave, West Saint PaulMN 55118 United States
You received this email because you signed up on our website or made purchase from us.


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Daily Admission per person
Daily Admission includes on-grounds admission, midway rides, all shows and entertainment as listed at www.shawvillefair.ca
Thursday $20
Friday $25
Saturday $30
Sunday $30
Monday $25
Children under the age of 2 NOT RIDING MIDWAY RIDES are FREE.
Daily Admission sold to 10 PM each day (gate closing time)
No admission after 10 PM.
Admissions Rules
- No entry or re-entry after 22:30 (10:30 pm)
- No pack, sacks, coolers or tote bags allowed on the grounds
- All purses & baby bags, strollers, etc. will be checked for alcohol
- No entrance of intoxicated persons allowed
- Expulsion of intoxicated and unruly patrons by police – anyone fighting will be expelled with no re-entry to the grounds with bracelets removed
- All minors caught drinking will be expelled with no re-entry
- Zero (0) tolerance for disrespect of people or property


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Housed in five 110-year-old buildings – the remaining heritage of the Ahuzat Bayit settlement – alongside a modern 42-floor tower, Six Senses Tel Aviv is set to open in 2025.
Considered the largest and most important preservation project in Tel Aviv, once complete it will house the ten-floor, 140-room Six Senses hotel, as well as 55 serviced residences.
Building and preservation works on the original five buildings, which date back to 1909, will be overseen by preservation architects Amnon Bar-Or Architects and structural engineer Yaron Gal.
The new Rothschild 10 Tower will meet LEED Platinum sustainability standards.


text:
Manly Sea Eagles head coach Des Hasler has finalised his side for Friday night's clash against the North Queensland Toyota Cowboys at Brookvale Oval.
Tom Trbojevic's omissionhas resulted in a shuffle in Sea Eagles backline, while forward Kurt De Luis is set to make his NRL debut off the bench.
>>> Three Cowboys drop out of squad ahead of Manly clash
Manly Sea Eagles team list
5. Reuben Garrick
2. Jacob Saab
4. Morgan Harper
15. Moses Suli
3. Brad Parker
6. Kieran Foran
7. Daly Cherry-Evans
8. Taniela Paseka
9. Lachlan Croker
10. Martin Taupau
11. Haumole Olakau'atu
12. Karl Lawton
13. Jake Trbojevic
14. Dylan Walker
16. Ben Trbojevic
17. Toafofoa Sipley
18. Kurt De Luis
18th man
19. Cade Cust


text:
How to Cite
Item Difficulty in Item Analysis of Intelligence Test Items
Item difficulty is more important technique for item analysis for selecting and rejecting the test items which is utilized by research scholar in present study. This is an effective technique to check the difficulty value of items and on the base of Item difficulty items revised and modified. In current study 1500 participants were recruited voluntarily of required age groups children, adolescence and adulthood. In first try out of test development was prepared 100 items intelligence test. With the help of difficulty valued find out the difficulty value of the intelligence items in Ms excel 2010 and SPSS. There 31 items of intelligence test were rejected on the base of very low and very high difficulty value. Inter correlation within types of intelligence test was high Accepted items item difficulty level was 0.5 and all around above it's or equal. Through item analysis we rejected 23 items those difficulty value was less than 0.5 and greater than 0.89. item difficulty range was 0.5- 0.88. Eigen values of intelligence types likewise linguistic, observational, mathematical and logical were .88, 776, .80 and .99 respectively. These Eigen values were in acceptable range, thus present intelligence test was reliable.Authors
- Nighat Gul
- Ph. D Scholar, Department Psychology, Shaheed Benazir Bhutto Women University Peshawar KPK Pakistan
- Dr. Sonia Shagufta
- Head of the department, Department psychology, Shaheed Benazir Bhutto Women University Peshawar, KPK, Pakistan
- Dr. Shagufta Parveen
- Assistant Professor, Department Psychology, Hazara University of Mansehra, KPK, Pakistan


text:
Jansen Panettiere, brother of Hayden Panettiere, dies at 28
Jansen Panettiere appeared within a number of tv reveals and made-for-TV videos, such as a principal job on Nickelodeon's animated present "The X's."
Ny – Jansen Panettiere, the youthful brother of actress Hayden Panettiere, has died at age 28, according to various media experiences.
A agent for Hayden Panettiere confirmed Jansen's loss of life to CNN and told the outlet which the lead to of loss of life is not known at this time.
While no trigger of demise has been released, no foul engage in is suspected, in accordance into a report from TMZ.
5 several years youthful than his sister, Panettiere followed his older sister into acting within the early 2000s. He appeared inside a variety of kid's television shows and made-for-TV movies, which includes voicing Truman X on Nickelodeon's "The X's" and other roles in "Even Stevens," "Tiger Cruise," and "Ice Age: The Meltdown." He continued to act by way of 2022 and was associated inside of a variety of future initiatives, in accordance to his IMDB page.
Final thirty day period, Jansen shared a photo with sister Hayden, playfully captioned "Not the primary haircut she's tried out to give me."
Though he's most recognized for his performing, Panettiere's Instagram site displays he was keen about making art and had started out promoting his artwork.
According to the bio on his web-site, art was a method to manage together with his anxiety and despair.
"After spending time in LA being an adult he was ridden with horrible nervousness and melancholy; this era in his daily life eventually made a non secular clarity that drove him to start painting his difficulties, one by one," his web page bio states. "With much more than 50 items, Jansen proceeds to recover himself also as other folks together with his visceral and emotive get the job done."
Panettiere was born on Sept. 25, 1994 in Palisades, The big apple. He is survived by both equally moms and dads and his sister.


text:
Now that the Democrats are in control of Congress again and all the Republicans are turning out to be gay hypocrites, we can all celebrate once again. And what better way to celebrate than with a massage and dinner in Hollywood. Prohibition is over kiddies! An emailer informs us of some tasty happenings in H'wood:
It involves the long-shuttered Vogue Theater on Hollywood Boulevard, which hasn't screened movies in who knows how long and was last used from 1997 to 2001 by an outfit named Ghost Expeditions which allegedly cleared the place of its supernatural spirits. Now something even weirder is proposed for the site: a dinner theater. But this ain't your dad's dinner theater or even Elizabeth Whatshername's Curtain Call Theater in Tustin. It's more like your weird hipster cousin's dinner theater.
An outfit by the name of Supperclub (www.supperclub.com), which already has outposts in San Francisco, Amsterdam and Rome, wants to come to Hollywood. They describe themselves as a high-end restaurant offering two evening avant-garde theatrical performances. In their own words it's a place where "patrons can enjoy the creative arts in a theatrical environment that stimulates all the senses: sight, sound, smell, taste and touch."
They described their plans for the décor inside, which include an all white room and beds.
The Planning Department will hold a hearing tomorrow (11/9) on their request for a conditional use permit for a full liquor license in conjunction with a 17,852 square-foot restaurant theater with 507 seats having live entertainment, public dancing and theatrical massage.
No definition has been given for theatrical massage, although the possibilities are mind-boggling. When the Supperclub people made a presentation to the local Hollywood neighborhood council last night, the stakeholders in attendance jumped to conclusions and expressed their worries that the combination of theatrical massage and beds would result in...yep, you guessed it, sex.
No, no, the Supperclub people protested to no avail, that was not their intent at all. What they want to do is offer people willing to pay for it an arty-farty evening.
Thanks for the info!


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Texas Instruments (TI) recently introduced a scalable family of Arm Cortex-M0+ microcontrollers (MCUs) with a variety of computing, pinouts, memory and integrated analog options.
According to the introduction, designers can choose from a variety of compute options from 32MHz to 80MHz with multiple configurations of math acceleration and integrated analog signal chain components, including MCU on-chip zero-drift operational amplifiers and 12-bit, 4MSPS precision analog-to-digital converters.
The Arm Cortex-M0+ improves CPU performance from the Cortex-M0 (2.33 CoreMark/MHz to 2.46 CoreMark/MHz) and also integrates a memory protection unit (MPU), single-cycle I/O interface and microtracking cache (MTB) with the following key features.
- Armv6-M architecture
- AHB-lite bus interface, von Neumann bus architecture with optional single-cycle I/O interface
- Thumb / Thumb-2 subset instruction support
- 2 segment pipeline
- Optional 8-area MPU with subareas and background areas
- Non-maskable interrupts + 1 to 32 physical interrupts
- Wake-up interrupt controller
- Hardware single-cycle (32×32) multiplication
- Multiple sleep modes with integrated wait-for-interrupt (WFI), wait-for-event (WFE) and sleep-on-exit functions, sleep and deep sleep signals
- Multiple retention modes depending on implementation
- JTAG and serial line debug ports with up to 4 breakpoints and 2 watchpoints
- Optional microtrace cache
The release of dozens of Texas Instruments MCUs, supported by intuitive software and design tools, enables the MSPM0 MCU product family to help designers spend more time innovating, reduce evaluation and programming time, and cut design time from months to days, said Texas Instruments.
MSPM0L and MSPM0G MCUs are available through TI.com.co.uk and authorized distributors. These MCUs are available in a variety of package sizes, including 16- to 32-pin package options and 8 kB to 128 kB flash memory options.


text:
33. William Knife‐Man (Reservation Dogs, S01E01)
Honourable Mention
- Earl's goodbye (Blindspotting, S01E01)
- VMA rehearsal (Dave, S02E10)
- Sex scene (Brand New Cherry Flavor, S01E04)
Stray Observations
- "Look, obviously, imperialism was bad. Shouldn't kill people, steal their land, and then make them dance. Everybody knows that. But it's humanity. Welcome to history. Welcome to America." (The White Lotus, S01E05)
"I don't steal from people, you know?"
"They stole from you! They stole all of this from you. You know that."
"But it's different. It's, it's different people."
"No, they're the same people. They're all the same people. Don't you see they're all the same people? All of these people, at some point, have stolen from someone like you." (The White Lotus, S01E05) -
"Greg, I told you to get the fuck out."
"No. I still wanna fuck you." (The White Lotus, S01E05) - "Sometimes, just watching them eat every night makes me wanna gouge my eyes out. The Lotus-eaters. 'Hateful is the dark-blue sky, vaulted o'er the dark-blue sea. Death is the end of life. Ah, why should life all labor be?'" (The White Lotus, S01E05)
- "Today is my Mobo Triton randonneur, so I'll be off the grid for a bit." (Blindspotting, S01E08)
- "Hold up, he had a partner who looked kinda like Krayzie Bone and they had lit a dude on fire that one time?" (Blindspotting, S01E08)
- Helen Hunt flashing (Blindspotting, S01E08)
"Marriage is about love and responsibility."
"Are you just reading off the walls right now?" (Blindspotting, S01E08) - ♫: Too $hort – "Gettin' It" (Blindspotting, S01E08)
- "I was in the garage eating sorbet." (Blindspotting, S01E08)
- Blindspotting Season Grade: C
- "Your life isn't real, and I didn't save it." (Rick and Morty, S05E08)
- "No, Rick, it is you who must nibble my cloaca, or 'bird asshole.'" (Rick and Morty, S05E08)
- "Disloyalty acknowledged." (Rick and Morty, S05E08)
"Anyone follow you?"
"No. No one's following."
"Yeah, just like his Insta." (Reservation Dogs, S01E01) - ♫: Wu-Tang Clan – "Protect Ya Neck [The Jump Off]" (Reservation Dogs, S01E01)
- ♫: Broncho – "Class Historian" (Reservation Dogs, S01E01)
- "What kind of gang wears both red and blue?" (Reservation Dogs, S01E01)
- ♫: LABRYS – "Deeper" (Reservation Dogs, S01E01)
- ♫: Samantha Crain – "Joey" (Reservation Dogs, S01E01)
- ♫: Unidentified "Gone are the days of my youth that I never knew" song (Reservation Dogs, S01E02)
- "So, a dame and a flying Buick." (What If…?, S01E01)
- "Who needs a plan? I have a shield." (What If…?, S01E01)
» "I should have been the 'I.'" (Dave, S02E10)
- "Fuck you, Anthony Jeselnik!" (Dave, S02E10)
"You just need to choose the material of the graft. Is it gonna be your skin or a cadaver?"
"I don't want to use either. Corpse's dick?" (Dave, S02E10) -
"Dave! Would you please be quiet?"
Both: "Sorry." (Dave, S02E10) -
"You ready to sodomize the world with that brand new dick?"
"Is that ass-fuck?"
"It's the professional way of saying it, yeah." (Dave, S02E10) - Directed by Alma Har'el (Dave, S02E10)
- Dave Season Grade: C
- The North Water Season Grade: C
- "I can't lose you too, because if I do, I'm [sighs] I'm going lime. I'm going deep lime." (Ultra City Smiths, S01E05)
"Deputy Mayor Jeff Thumb."
"Congressman Chris Pecker."
"Pecker. Thumb."
"Last names. Burdens. For me and you."
"Mine's not. Mine's a thumb."
"Yours is a dick, so I'm not in your club. Thumbs are cool."
"Dicks are cool. Dicks are very cool."
"Why are dicks cool?"
"Why are thumbs cool?"
"It's the thumb that allows us to pen an essay, turn a nut, pick up a coin, or button a shirt. Can you pick up a coin with your dick? Give it a shot."
"I'm not stupid, Thumb. I know I can't pick up a coin with my penis. But there is one thing on your little list there that I could totally do, with it. If I had old-fashioned ink." (Ultra City Smiths, S01E05) -
"Does everybody have their river guns?"
"No. I left mine at Starbucks." (Ultra City Smiths, S01E05) - "He went full Schumer." (Brooklyn Nine-Nine, S08E01)
"She's probably too busy to see friends."
"And yet I have time to see my friends and be a father and do my job and straight-up crush it at Goat Simulator on my Switch." (Brooklyn Nine-Nine, S08E01) -
"Hey, my client's in the conference room, but before we go in there, it wasn't easy getting her to agree to talk with a cop, so don't be too cop-ish. Just be normal."
"Got it, normal, not too cop-ish. Won't be a problem."
Mrs. Doubtfire "Helloooo!" (Brooklyn Nine-Nine, S08E01) - "Yeah, got a low-drop fade with a crisp lining. I'm all about supporting Black businesses." (Brooklyn Nine-Nine, S08E01)
"It's clearly bogus, but an officer did break one of his fingers. Probably from tackling her to the ground."
"Yeah, or from pointing it so hard at everyone but himself."
"Who are you performing this for, Jake?" (Brooklyn Nine-Nine, S08E01) -
"You live with your mom?"
"My ma lives with me…in her house." (Brooklyn Nine-Nine, S08E01) - "I have successfully hidden it for months – not very well, I might add. I made small talk with Peralta on five separate occasions, and he never even batted an eye. He just blathered on about someone named…Wario." (Brooklyn Nine-Nine, S08E01)
- "Nobody's on board with my scheme? Is it because I called it a scheme? I can say something different. Nobody's on board with my stratagem?" (Brooklyn Nine-Nine, S08E02)
"This is surprising. You're usually a lot more petulant when we don't go along with your schemes."
"Stratagems." (Brooklyn Nine-Nine, S08E02) -
"Uh, you do know there's no phone reception at the lake house."
"No! How am I gonna catch Pokémon?" (Brooklyn Nine-Nine, S08E02) -
"Let's just say you're definitely gonna want my nip tips. Tips that nip a problem in the bud."
"Why don't you just say 'tips'?" (Brooklyn Nine-Nine, S08E02) -
"Sir, you have something on your pants."
"Huh, I've sat in some sap, like a sap."
"At least you have a sense of humor about it."
"Not intentionally. I was upset and stumbled into accidental wordplay." (Brooklyn Nine-Nine, S08E02) - "I'll have a snack of some water." (Brooklyn Nine-Nine, S08E02)
- "Scully, don't throw chips at my baby!" (Brooklyn Nine-Nine, S08E02)
- "There's no reception. I'll just run back. I haven't done cardio in 20 years. How hard can it be? It's immediately awful!" (Brooklyn Nine-Nine, S08E02)
- "Das Doppelte Lottchen!" (Brooklyn Nine-Nine, S08E02)
- "I knew my stratagem had classy origins." (Brooklyn Nine-Nine, S08E02)
"I finally spot a corn crake, and my eyes are swollen shut."
"It's okay, Kevin. I'll describe it to you. Okay, have you ever seen a duck?" (Brooklyn Nine-Nine, S08E02) - "Those are some hot Pantones." (Brooklyn Nine-Nine, S08E02)
"Okay, whoa, whoa. Pump the brakes there, Sonic."
"Sonic the Hedgehog. You've been hogging that hedge while I was out on a ledge. No, you didn't have to deal with anyone saying it was a bad idea, so you don't get the credit either. This was 100% all me, Dr. Robotnik."
"Sonic's archnemesis!" (Brooklyn Nine-Nine, S08E02) - "I'm a trash man who only knows trash birds." (Brooklyn Nine-Nine, S08E02)
- "Listen, Phoebe, problems, they're like mushrooms, yeah? The longer you leave them in the dark, the bigger they get." (Ted Lasso, S02E04)
"Why did you bring a date to the team Christmas party?"
"The French believe that having a beautiful woman around is always a good thing."
"That was not true with the Helter Skelter murders." (Ted Lasso, S02E04) - "Am I getting notes of Beijing?" (Ted Lasso, S02E04)
"You're willing to miss a puppet show by Daniel Craig and Rachel Weisz? 'Cause that sounds like a lot of fun."
"Don't get me wrong, they are incredible. But all I really want to see those two do together is fuck." (Ted Lasso, S02E04) - ♫: Folk Implosion – "Natural One" (Brand New Cherry Flavor, S01E01)
- "'The killer was not like a jellyfish.'" (Brand New Cherry Flavor, S01E01)
- "This bitch just puked a cat!" (Brand New Cherry Flavor, S01E02)
"Oh, God! It bit your dick?"
"No, no, no. The bite causes a very painful erection."
"Yeah, yeah, yeah. She's right."
"Yeah, very dangerous."
"God, is it an allergic reaction or…?"
"I'll get some ice."
"Some… For his dick?" (Brand New Cherry Flavor, S01E04) - "Why is Lou Burke's son eating dog food?" (Brand New Cherry Flavor, S01E05)
- ♫: Primus – "Those Damned Blue-Collar Tweekers" (Brand New Cherry Flavor, S01E06)
- "Did you eat this man?" (Brand New Cherry Flavor, S01E06)
- ♫: Concrete Blonde – "Tomorrow, Wendy" (Brand New Cherry Flavor, S01E06)
- "If you're gonna throw up, please let me know so I can turn away. It's different if it's a kitten. Okay, so whose door can we knock on for some spontaneous sex magic?" (Brand New Cherry Flavor, S01E07)
- Brand New Cherry Flavor Season Grade: D
Still the AR™TV World Drama Champion: The Underground Railroad
Still the AR™TV World Comedy Champion: Girls5eva


text:
Distinguished Lecture Series: H.E. Maria Castillo Fernandez (April 14, 2021)
페이지 정보
On April 14, EU Centre invited H.E. Maria Castillo Fernandez, the EU ambassador to South Korea, for a special lecture. Titled "EU as a global actor," the lecture covered various EU-related topics such as EU's partnership with South Korea and several recent issues like the post-Brexit UK-EU relations. Throughout the presentation, she stressed EU's importance as a multilateral actor. She started with a brief overview of EU's history from its inception as a peace project. Later on, she explained EU's pioneering role in climate change and international security. After the lecture, the floor was open to participants for Q & A session. Students actively asked questions, and a lively discussion continued.
The recorded version is available in: https://youtu.be/2qn4K7Fc0lQ
- 이전글Distinguished Lecture Series: Dr.Wolfgang Pape (May 12, 2021) 21.06.01
- 다음글Info-session for 2021 Spring Semester 21.03.04
등록된 댓글이 없습니다.


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Academic Scholarships
We are excited to announce our Scholarships for Year 7 to 9 and Sixth Form – Your Gateway to Excellence!
At St. James', we believe in nurturing academic excellence, leadership skills, and individual talents. Our scholarships for students in Years 7 to 9 and Sixth Form are designed to recognise and reward outstanding achievements, both in and outside the classroom.
Are you a dedicated, passionate, and ambitious individual with dreams of pursuing your vision? We are thrilled to announce the Year 7 and 8 Visionary Scholars Award, an incredible opportunity for you to turn your dreams into reality.
Why choose St. James' School?
Investing in Your Future: We believe in the power of education to transform lives. This Scholarship is a testament to our commitment to helping talented individuals achieve their educational and career goals.
Diverse Fields of Study: Whether you aspire to be a scientist, artist, engineer, or entrepreneur, our scholarship is open to a wide range of fields. Your passion is our priority.
Merit-Based: We recognise and reward excellence. Our selection process is based on merit-based awards across a range of subject choices.
Global Reach: We welcome applicants from all over the world. Our Scholarship programme is open to international applicants, promoting diversity and cross-cultural exchange.
All applicants will sit an exam and be given a project or test in their chosen subject area. Don't miss this incredible opportunity to make your dreams come true!
To apply for this Scholarship, please fill out the form below and a member of our Admissions Team will be in contact with you shortly.


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For the Week of May 10
Arts and Performances
ND Playwrights NOW! A Night of Exciting Zoom Theatre
A virtual reading of scenes written by ND playwrights created in FTT's spring 2021 playwriting course, taught by Anne García-Romero. Playwrights include James Cullinane, Michael Enright, Maggie Finger, Justin George, Lamont Marino, Tim Merkle, Ella Mylod, Ian Oh, J.P Spoonmore and Keegan Wolohan.
Tuesday, May 11; 7:30 p.m. on YouTube
SAO Comedy Show: An Evening with Jay Pharoah and His Celebrity Friends
Pharoah, the six-season SNL alum, is well known for his stellar impressions of President Barack Obama, Jay-Z, Denzel Washington, Kanye West and many others. Pharoah also made a splash with his memorable character, Principal Daniel Frye, based on his actual high school principal. Space is limited, so make sure to reserve your seat.
Tuesday, May 11; 9 p.m. in Notre Dame Stadium
Michiana Young Playwrights Project 2021
Ten-minute plays by local middle and high school playwrights, performed on Zoom by FTT students.
Friday, May 14; 7:30 p.m. on YouTube — plays by sixth- and seventh-graders from the Stanley Clark School
Saturday, May 15; 7:30 p.m. — plays by seventh- and eighth-graders from Montessori Academy at Edison Lakes and 11th-graders from Trinity School at Greenlawn
Deadlines or Registrations
Submissions for a Library Research Award Due May 12
All ND undergraduates — in a brief essay, tell Hesburgh Libraries how you used library resources, e.g., online search tools, spaces, consultations, etc., for your assignments and projects completed in summer 2020, fall 2020, Winter Session 2020-21 or spring 2021. Check out past winning essays and learn more about the award at library.nd.edu/library-research-award.
Due by Wednesday, May 12; 11:45 p.m.
Charles Edison Foundation Fellowship (Extended Application Deadline)
Scientia has extended the application deadline for the 2021/2022 Charles Edison Foundation Fellowship to Friday, May 21. This award provides two undergraduate students with $1,500 each to help fund on-campus research. Interested students can submit their application through Scientia's online form. Any questions regarding the fellowship can be directed to Scientia's staff at firstname.lastname@example.com.
Due by Friday, May 21; 11:45 p.m.
Educational and Research Opportunities
Professional Headshots
Wear your business professional attire and get your picture taken to use on professional sites.
Monday, May 10; 11 a.m. to noon on the fifth floor, Duncan Student Center
Tuesday, May 11; 11 a.m. to noon
Lectures and Presentations
Mexico Virtual Lecture Series: "Building Mexico – Tenochtitlan in the 16th Century"
Michael Schreffler's research centers on the art and architecture of the transatlantic Spanish world in the 16th and 17th centuries. His work examines the ways in which representation — in the form of visual images, architectural ornament and descriptive texts — facilitated change in colonial Spanish America.
Wednesday, May 12; noon to 1:30 p.m. via Zoom
Panel Discussion — "A Partnership for Research: IHD and the Kellogg Institute"
Explore integral human development (IHD) at the Kellogg Institute, as revealed by faculty, staff and students. This panel will take up key questions about the role of IHD in the intellectual life of Kellogg, how it may enrich research, its impact on research planning and the role of community partners in IHD-inspired research. Registration required.
Thursday, May 13; noon to 1 p.m. via Zoom
Book Launch: Peter Cajka's "Follow Your Conscience"
The Department of American Studies and the Cushwa Center for the Study of American Catholicism will celebrate the publication of Peter Cajka's book, "Follow Your Conscience: The Catholic Church and the Spirit of the Sixties" (University of Chicago Press, April 2021). Rev. Stephen M. Koeth, C.S.C., will engage Cajka in conversation about the book. Registration is required.
Thursday, May 13; 4 to 5 p.m. via Zoom
Safety, Parking and Traffic
Student Move-Out Parking Lot Closures
The following parking lots will be closed from Friday, May 14, through Thursday, May 20, for student move-out: Fischer, Rugby, Walsh Architecture and the west side of Dorr. Please have all vehicles moved out of these lots by end of business on Thursday, May 13. For any questions, please contact Thomas Kauble at firstname.lastname@example.com or 631-2602.
Also this Week ...
Expanded Building Hours for Hesburgh Library
Hesburgh Library will be open:
∙ Sunday, May 9: 9 a.m. to 4 a.m.
∙ Monday, May 10, to Friday, May 14: 7 a.m. to 4 a.m.
∙ Saturday, May 15, and Sunday, May 16: 9 a.m. to 4 a.m.
∙ Monday, May 17, and Tuesday, May 18: 7 a.m. to 4 a.m.
∙ Wednesday, May 19: 7 a.m. to 11 p.m.
Find more info on library access and services at service-continuity.library.nd.edu.
Study at the Snite Museum of Art
Use the galleries as inspiring and quiet study spaces during this semester's reading days and finals week. Tables, chairs and outlets will be provided in select galleries. Take a study break to wander the galleries, listen to art-inspired playlists or color. Study spaces are first-come, first-served. HERE and museum policies will be enforced.
Wednesday, May 12; 10 a.m. to 5 p.m. in the Snite Museum of Art
Thursday, May 13; 10 a.m. to 7:30 p.m.
Friday, May 14; 10 a.m. to 5 p.m.
Saturday, May 15; noon to 5 p.m.


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Red Hat blog
The Machine Config Operator (MCO) in OpenShift exposes a "Pause" feature on its MachineConfigPools that allows users to halt config deployment. We made some changes in 4.11 to try to make that feature "safer", and this blog tries to give some context around what pausing a MachineConfigPool actually does under the hood, the consequences/tradeoffs, and a small glimpse into how the MCO team thinks about exposing and evolving features like this.
The MCO Added A New Critical Alert
Along with OpenShift 4.11 the Machine Config Operator (MCO) added a new feature -- an alert to notify users when a certificate rotation is being prevented by a paused MachineConfig pool.
For users who aren't using the Machine Config Pool's Pause
feature, you will never experience this alert.
For users who are using the Pause
feature, especially those who leave their machine config pools paused long-term due to maintenance windows, etc, this will hopefully make the risks and tradeoffs more apparent, and protect you from weird cluster failure modes.
But Why Did We Do That?
The short answer is: Because we are trying to help you.
The long answer is something like: The consequences of long-term pausing a MachineConfigPool
are not immediately clear and predictable without a detailed understanding of internal OpenShift workings, and some of those consequences are very unfortunate.
We also don't really know what you're doing all the time or why you're doing it, so sometimes it's hard for us to know how to help without getting in the way.
The Relevant Parts of the MCO
If you aren't familiar with entirely how the MCO works, you can check out the documentation. several
This is an oversimplification, but for our purposes here, in "standard operation" the MCO's machine-config-operator
- Watches and reacts when certain cluster objects change
- Regenerates a CRD object called
when those objects change
And then the MCO's machine-config-controller
- Watches for
changes - Uses
to generate/regenerate templateMachineConfig
and other special controller-generated config - Watches for
changes - Merges alllllll that
(template + user + generated) together deterministically intorendered-configs
grouped byMachineConfigPool
- Coordinates assignment of that rendered-config to nodes via a
annotation (and the resulting reboots and drains) across a pool
And then the machine-config-daemon
on the Node
- Applies the specified
to itsNode
So objects change, the MCO reacts to it, sqishes it all of the config into a rendered-config
, and then assigns that rendered-config
to Nodes
at a time, where the Node's
reacts to it and applies the desiredConfig
(There are a bunch of bootstrapping/special cases, but pause does not currently affect those, so I'm going to hand-wave those away for our purposes here)
Some of you have never used Pause
and may have no idea what I'm talking about, so before I go too far:
- The
has a field in its CRD named.Spec.Pause
. It has actually been in there since the "beginning" of the MCO when the machineconfig types were initially added. - When set to
that field instructs the MCO's node controller uses it to prevent configuration changes from being rolled out to nodes.
It's useful when you want to prevent the MCO from changing node config, or when you want to stack up a whole bunch of changes and only take a single reboot.
Much like the initial MachineConfigPool
field, the logic around pause was part of the original machine-config-controller
design also.
So the sagely original developers knew that there would be cases where you wouldn't want configuration to roll out instantly, and they planned for it. What they maybe didn't plan for (and couldn't really have planned for) was all of the users who might eventually use it, the reasons it might be eventually used, and the long-term consequences and interactions resulting from its use.
So What Does Pause Actually Do?
The .Spec.Pause
field in the MachineConfigPool
CRD only does one very specific thing: It prevents the MCO's node_controller from changing a node's desiredConfig annotation.
That's it. That's all it does. It happens right here and we just return early during the pool sync without doing anything else.
Everything else in the MCO happens as normal. It doesn't pause the entire MCO. It's doesn't even pause "most" of the MCO, it just keeps that one thing from happening -- which conveniently is enough to prevent any new MCO config changes from being applied to any nodes.
(NOTE: Emphasis on new config changes here because if desiredConfig
has already been set on a node, and the machine-config-daemon
is already in the process of applying a configuration, pause will not stop it, because that's not what it stops).
To reiterate -- things pause stops:
- The MCO's
from setting thedesiredConfig
annotation on nodes in a pool
This, by extension, does stop the machine-config-daemon
from applying configuration to nodes in the paused pool because:
- The
only applies config when thedesiredConfig
annotation changes
Things Pause
does not stop:
- New
generation - New template
generation/regeneration - New rendered
generation - A user manually setting
for a node (please do not do this) - A toolchest falling down the stairs
The MCO As The Postal Service
So in general MCO really likes to think of itself like the postal service. One of its most common defenses of whether or not we should be inspecting or surfacing some sort of config-specific data is "we don't look in the envelope, we just deliver it."
Yes, there are places where maybe we cheat a little and snarf an object out of the cluster and pack the envelope (which is maybe why it's okay for us to take a peek in that envelope later), but for the most part we try to hold to that philosophy.
So you have this big sprawling MCO postal service:
- it services every city (each
) - it has a bunch of intake mailboxes that people drop mail in (templates, cluster object changes,
- it has sorting and consolidation offices (
) - it has the "last mile" letter carrier (
)- that puts the actual mail (
rendered MachineConfig
) - in your mailbox (
annotation) - so that the recipient (
) can open it and deal with it.
- that puts the actual mail (
This metaphorical postal service also has a very weird feature (Pause
), wherein:
- the Mayor (
) of a city (MachineConfigPool
) can call in and say "stop delivering mail to my city until I tell you that you can resume delivery" (.Spec.Pause
) and the postal service will obey and stop that "last mile" letter carrier (node_controller
) for that city from delivering mail.
I know, it's not 100% perfect, but it should get us where we need to go.
(this diagram is obviously a hand-wavy oversimplification)
The Mayor Said To Stop, So We Did?
So let's say the mayor of the city of worker
has called the postal service and said to stop delivering mail.
As we said, this Pause
in mail delivery doesn't stop anything other than that last mile letter carrier delivering the mail to residents' mailboxes. People still mail letters, the mail still gets picked up, and packed and sorted, and loaded onto mail vehicles, but the mail never gets delivered.
Residents, of worker
of course, could continue to open and deal any mail that had previously been delivered to their mailboxes, but they wouldn't get any new mail (and they obviously can't open and use mail they don't have).
To those doing the mailing, everything appears to be functioning perfectly -- it all still gets collected.
But to those expecting to receive mail, things are different: nothing shows up. Maybe that's okay for the most part. Maybe there actually wasn't any mail set to be delivered. Maybe the residents are busy and can't or don't want to deal with their mail right now anyway.
But let's say there is a resident of worker
out there waiting for a really important piece of mail. Something with a deadline. Something like...their new passport, so they can go on vacation in a week. If they don't get it in time, they can't travel, and if they can't travel they're going to miss their trip.
Well, now we have problems because this particular mail is very important, and it's also not being delivered because the Mayor told the postal service not to.
Your Nodes Were Expecting A Very Important Letter
This "important mail not being delivered" scenario is exactly why we had to add the alerting around Pause
. In our case, the "important mail" is the certificate bundle that controls trust between the Node
and the cluster -- it is "mailed" by the apiserver operator, and it expects it to be delivered in a timely fashion. If the old bundle expires before the new one shows up, your Node
stops talking to the cluster and becomes unmanageable.
More specifically, I'm referring to the kube-apiserver-to-kubelet-signer
certificate, which is managed by the kube-apiserver operator, which it rotates every 292 days (lifetime is 365 days, rotates at 80%).
It rotates it by updating the kube-apiserver-to-kubelet-signer
secret object in the openshift-kube-apiserver-operator
And I said earlier, the MCO pays attention to many cluster objects so it can react when they change and reconcile. That apiserver secret just so happens to be one of the cluster objects that the machine-config-operator
pod cares about.
So when the apiserver rotates that certificate and the secret object changes, the machine-config-operator
notices and regenerates clusterconfig/renderconfig, which results in a new set of rendered MachineConfig
being generated containing that new certificate bundle that will totally save the day!
And that super important rendered MachineConfig
just...sits there behind Pause
. :(
We're Telling the Mayor There Will Be Trouble
So that's what the alert is for. Back in our metaphor, the alert we added is probably something like: "when we know 'important' mail is waiting at the post office, make sure the Mayor knows there is impact. Call him on the Big Red Telephone, and he can decide what to do".
But If It's So Important, Why Not Just Deliver It?
So now you're probably thinking "well why not just let that 'important mail' -- that certificate -- through?". It is "platform" config, not user config. We know where it's going and can sneak it in without a reboot, why not just do that?
Well, the short version is that:
- It's sets a weird precedent that pause isn't really pause
- We don't want to lie to you
The "contract" right now that we have with users is more or less that when pools are paused, no configuration gets rolled out. It's been that way since the beginning of time and people are used to it. Pause doesn't lie. The MCO will not move a node to a new configuration if the pool is paused.
Lie To Me
Alright, so what if we did decide to lie to you? We tell you your pool is paused, but we give a special dispensation to "important config" (however we classify it) and we just sneak it though and have the machine-config-daemon
just write it to the node.
That would mean (among other things):
- We have to have a way to know what is/isn't "important" enough to bypass pause
- We have to tell you about that special case (maybe in a "red box" in our documentation that you may or may not happen to read)
- We now have to apply only a subset of config (which the
does not currently do) - Our
annotation will be a lie, because we aren't actually in thatcurrentConfig
anymore (MachineConfig
doesn't really have a status that supports "nuance" at this point -- either you're in a config and that's good, or your not and that's a problem) - Were there to be a severe enough error while sneaking through that "important" config, it could have stability consequences that the user didn't get to plan for.
We'd Rather Tell the Truth
So there isn't isn't an immediately obvious solution here without having to trade something:
- Maybe we break out certificates into another operator that only reconciles certificates (but now the node config is a combination of "whatever is in machineconfig" + "whatever the 'certificate operator' applied")
- Maybe we do a "one-off" rendered-config that's special that only contains the certificate changes (but now we're moving off of the current config "without the user's consent")
- Or maybe the alert is enough (but the user has to fix the issue themselves and potentially take an unwanted outage depending on what kind of config is pending)
One of those trades might eventually end up being right, but we're not quite sure yet, and regardless the ramifications would need to be fully communicated and understood.
How Do You Want The MCO "Postal Service" To Handle Important Deliveries?
So like I said at the beginning -- we're not always entirely sure how you're going to use what we put out there. We want to help you, but we also want to stay out of your way. Ideally we would be 100% helpful and 0% "in your way", but understandably that's difficult given the wide variety of use cases.
Maybe you'll use Pause
how we thought it would be used. Maybe you will use it an entirely different way, but either way we would love to know what you think.
When the MCO isn't worrying about the consequences of Pause
, we're working on cool new things like OCP CoreOS layering which lets you use Containerfile (Dockerfile) syntax to configure your nodes -- check it out!


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text:
- Research
- Open access
- Published:
Evaluation of the effect of gentamicin in surgical perfusion solution on cataract postoperative endophthalmitis
BMC Ophthalmology volume 22, Article number: 410 (2022)
To evaluate the effect of gentamicin in surgical perfusion solution on endophthalmitis incidence after cataract surgery.
A retrospective analysis of endophthalmitis incidence was conducted in two groups of patients who underwent cataract surgery, with (Group B) or without gentamicin (Group A) in the surgical perfusion solution. Endophthalmitis incidence, the isolated pathogenic bacteria strains and their antibiotic sensitivity, and the drug-resistant genotype of the pathogens were examined.
The incidence of endophthalmitis in patients of group A was 0.8‰. Thirteen pathogenic bacterial strains were isolated from the patient samples in group A, including 8 strains of Staphylococcus epidermidis, 1 Staphylococcus aureus, 1 Streptococcus pneumoniae, 1 Streptococcus bovis, 1 Enterococcus faecium and 1 Morganella sp. The incidence of endophthalmitis in group B patients was 0.2‰, which was significantly lower than that in group A (P<0.05). Five strains of pathogenic bacteria were successfully isolated, including 2 strains of Enterococcus faecium, 1 Enterococcus faecalis, 1 Staphylococcus epidermidis and 1 Staphylococcus aureus. There was no significant difference in the proportion of Staphylococcus strains in all isolated bacteria between the two groups (P > 0.05). However, the proportion of Enterococci isolated in group B samples was higher than that in group A (P < 0.05). There were more gentamicin-sensitive strains than levofloxacin-sensitive strains identified (P < 0.05). Interestingly, aminoglycoside-inactivating enzyme resistance gene was detected in Enterococcus strains.
Our data suggest that gentamicin-containing perfusion solution can reduce the incidence of postoperative endophthalmitis in cataract patients. However, the selective pressure imposed by gentamicin may facilitate the development of aminoglycoside-resistant Enterococcos strains.
Endophthalmitis after cataract surgery is a prevalent complication that seriously undermines the visual recovery of the patients [1]. Endophthalmitis is devastating condition resulted from the purulent inflammation of the intraocular fluids, i.e., the vitreous and the aqueous humor. Although the etiology of this condition can be both endogenous and exogenous, it is mostly secondary to intraocular surgeries, injections [2], or penetrating ocular trauma [3]. Acute endophthalmitis appears as a postoperative complication within 1–2 weeks after the surgical intervention, most commonly on the third to fifth postoperative day [4].
Cataract surgery is the most prevalent surgery performed in ophthalmology, but it is also considered as an ocular surface damaging event [5, 6]. A previous study reported that the overall incidence of endophthalmitis after phacoemulsification cataract surgery (PCS) was estimated to be 0.092% [5]. There was also a prevalence of ocular demodicosis and pathogenic conditions on ocular surface after cataract surgery [6]. It is also known that the incidence and severity of dry eye symptoms may increase after cataract surgery. To achieve the best outcome in cataract surgery, a healthy ocular surface is crucial. Patients with frail ocular surface or surface diseases are at higher risk of post-operative complications such as secondary infections [7]. In addition, multiple risk factors have been associated with endophthalmitis after PCS, including the insertion approach of intraocular lens [8], incision location [9], methods of preoperative disinfection of conjunctival sac [10] and patient age [11]. Although the incidence tends to decrease in recent years, the severe outcomes of endophthalmitis after PCS remains as a serious public health threat [5].
Staphyloccocus epidermidis is the most common pathogen causing endophthalmitis as a complication after cataract surgery. However, endophthalmitis can be caused also by bacteria, fungi, or viruses [12]. Perioperative cleaning of the conjunctival sac, disinfection of the surgical field with povidone-iodine and the topical use of antibiotics are preventative measures against endophthalmitis after cataract surgery [13, 14]. Antibiotics can be topically applied by instilling antibiotic eye drops, through anterior chamber injection after surgery or by adding in surgical perfusion solution [15, 16]. Intracameral antibiotics administration has been shown to reduce the risk of endophthalmitis [5].
On the other hand, the wide application of antibiotics also causes the development of drug resistance in the pathogens. For example, levofloxacin is a commonly used antibiotic to reduce the risk of endophthalmitis [17]. An increased incidence of levofloxacin-resistant Staphylococcus strains has been reported in ophthalmic infection [17], which limits its efficacy in the prevention of endophthalmitis after ocular surgery. In addition, methicillin-resistant Staphylococcus epidermidis (MRSE) strains have been found in more than 50% ophthalmic infections [18]. A wide spectrum of antibiotics has been developed for therapeutic use in coping with increased bacterial antibiotic resistance [12]. Recently, more alternatives are available in the market for therapy or the prevention of ocular infections [2, 4, 12].
A previous report suggests that the MIC90 (the minimum inhibitory concentration to inhibit 90% of organisms) of gentamicin against Staphylococcus is 8 µg/mL [19]. Its bactericidal effect is related to the ratio of peak concentration to the minimum inhibitory concentration (Cmax/MIC). A dose of 80 µg/mL gentamicin in perfusion solution has been adopted in certain surgical procedures, since this practice seems to show a satisfactory sterilization effect [19]. However, there is a lack of data regarding the beneficial effects of gentamicin on the prevention of endophthalmitis in cataract surgery. The aim of this study was to examine endophthalmitis incidence, isolate pathogenic bacteria strains, and characterize antibiotic sensitivity and the drug-resistant genotype in patients who underwent cataract surgery with or without gentamicin in the surgical perfusion solution.
Materials and methods
Research subjects
This was a retrospective controlled study. We enrolled all the patients who underwent cataract surgery from Jan 1, 2014 to Dec 31, 2017. Exclusion criteria were: patients without intraoperative intraocular lens implantation; patients with allergy to iodine reagent; patients without complete medical record. All the patients received levofloxacin eye drops 3 times a day for 3 days before surgery. Conjunctival sac was flushed with normal saline on the day of surgery, and 0.5% povidone-iodine was used for disinfection before surgery. After topical anesthesia, phacoemulsification was performed to remove the lens and to implant an intraocular lens. Levofloxacin eye drops were applied three times a day after the operation, which was terminated on day 30.
The enrolled patients were divided into two groups. A total number of 16,408 patients who underwent operation from Jan 2014 to Dec 2015 were assigned as group A (7712 males and 8696 females, average age of 72.8 ± 4.8 years), and no gentamicin was added to the surgical perfusion solution in this group. Endophthalmitis occurred in 13 cases (5 males and 8 females, average age of 74.8 ± 6.3 years) within 30 days after the operation, with a median onset time of 5 days. A total number of 21,469 patients (10,091 males and 11,378 females, average age of 73 ± 3.9 years) who underwent the operation from Jan 2016 to Dec 2017 were assigned as group B, and 80 µg/mL gentamicin was added to the surgical perfusion solution for this group. Endophthalmitis occurred in 5 cases (1 male and 4 females, average age of 72.4 ± 5.9 years.) within 30 days after operation, with a median onset time of 3 days. In case of suspected postoperative endophtalmitis, ophthalmic examination and echo B-scan were performed. The typical symptoms include conjunctival hyperemia and chemosis, corneal edema, tyndall sign and hypopion, exudate deposition on intraocular lens, opacity caused by vitreous infiltration, and severe abscess formation.
Bacterial culture
Aqueous humor or vitreous humor samples were extracted from patients with endophthalmitis and subjected to pathogenic examination. The specimens were inoculated into the fastidious bacterial enrichment solution immediately after collection. After culturing in a 37 ℃ incubator for 24 h, the samples were then transferred to the blood agar medium for another 48 h at 37 ℃ and Sapaul medium for 7-day culture at 28 ℃. The positive colonies were harvested for microbial identification and drug sensitivity test. If there were no observable colonies identified in the blood agar plate for 48 h or on the Sapaul medium for 7 days, the samples were reported as negative for both bacterial and fungal infections. The above procedures were completed in accordance with strict aseptic techniques to avoid contamination.
Bacterial identification and drug susceptibility test
VITEK-II automatic bacterial identification/drug susceptibility system (ID-AST card identification) was employed for bacterial identification and drug sensitivity test. Drug susceptibility card (AST-P535, bioMérieux, Marcy l′Etoile, France) was used together with the recommended quality controls: the negative control strain was ATCC29212 (Enterococcus faecalis, sensitive to high levels of gentamicin), and the positive control strain was ATCC51299 (Enterococcus faecalis, resistant to high levels of gentamicin). The results were interpreted based on the VITEK-II senior expert system identification system standards. As a result, Enterococci strains with high-level gentamicin resistance (HLGR) were identified. According to the clinical antibiotic dose in ophthalmic operation, the sensitivity test breakpoint of gentamicin was set as 80 µg/mL and the breakpoint of levofloxacin was set as 4 µg/mL.
Detection of aminoglycoside inactivation enzyme genes
The aac(6')-aph(2'') aminoglycoside inactivating enzyme genes of the identified Enterococcus with HLGR phenotype were examined by PCR method. The DNA sample of the bacteria was extracted using Bacterial Genomic DNA Isolation Kit (Norgen Biotek, Wuhan, China) according to the manufacturer's instruction. PCR was performed to examine the presence of aminoglycoside inactivation enzyme genes using the following primers: sense primer: 5'-GGTGGTTTTTACAGGAATGCC ATC-3'; antisense primer: 5'-CCCTCTTCATACCAATCCATACC-3 (Shanghai Sangon Bioengineering Co., Ltd, China). The following PCR conditions were used in a 20uL PCR reaction: 94 °C for 5 min, 30 cycles of denaturation at 94 °C for 30s, annealing at 52 °C for 30s, and extension at 72 °C for 60s. The PCR products were analyzed using 1% agarose gel electrophoresis, with a detection target at 642 bp.
Statistical methods
All analyses were performed by SPSS 22.0 statistical software (SPSS, Inc. Chicago, IL, USA). Data were calculated and compared by X2 test, and P < 0.05 was considered to be statistically significant.
In group A without the application of gentamicin, 13 cases of endophthalmitis (out of 16,395 patients) was recorded and confirmed, with an incidence rate of 0.8‰. In group B with the application of gentamicin, 5 cases of endophthalmitis were confirmed in a total number of 21,469 patients, and the incidence rate was 0.2‰ which was significantly lower than that of group A (p = 0.016).
Thirteen pathogenic bacterial strains were isolated from the patient samples in group A, including 8 strains of Staphylococcus epidermidis, 1 Staphylococcus aureus, 1 Streptococcus pneumoniae, 1 Streptococcus bovis, 1 Enterococcus faecium and 1 Morganella sp. (Fig. 1). The five strains of pathogenic bacteria in group B samples included 2 strains of Enterococcus faecium, 1 Enterococcus faecalis, 1 Staphylococcus epidermidis and 1 Staphylococcus aureus (Fig. 1). In all the samples, there were no detectable fungal infections observed. There was no significant difference in the proportion of Staphylococcus among the isolated bacteria strains between the two groups (P = 0.326). However, the proportion of Enterococcus strains was significantly higher in the pathogenic bacteria identified in group B (P = 0.044).
We also examined the sensitivity of all the isolated strains (18 strains) towards gentamicin and levofloxacin. There were more gentamicin-sensitive strains than levofloxacin-sensitive strains identified (Table 1, P = 0.018). The MICs of levofloxacin ranged from 1 to 32 µg/ml, and the MICs of gentanmicin ranged from 1 to 500 µg/ml (Table 2). Since Enterococci with high-level gentamicin resistance (HLGR) phenotype were identified, we further examined whether those strains harbors aminoglycoside-inactivation genes using targeted primers. The ATCC29212 Enterococcus faecalis strain (sensitive to high levels of gentamicin) was used as the negative control, and the positive control strain was ATCC51299 (Enterococcus faecalis, resistant to high levels of gentamicin). PCR and gel electrophoresis analysis showed that all the four Enterococcus strains contained aminoglycoside-inactivation gene (Fig. 2).
Endophthalmitis after cataract surgery is a serious complication with an incidence ranging from 0.6‰ to 1.4‰. An infection rate greater than 1‰ indicates the insufficiency of perioperative preventive measures [20]. The occurrence of endophthalmitis after cataract surgery is related to the number of bacteria in the intraoperative aqueous humor, the ability of the immune system to restrict pathogenic microorganisms and the effectiveness of perioperative antibiotic intervention [21, 22]. In this retrospective study, without gentamicin being added to the surgical perfusion solution, the postoperative infection rate was 0.8‰ and the confirmed incidence of endophthalmitis was close to the level reported in the literature. When gentamicin was present in the perfusion solution, the incidence of postoperative endophthalmitis was reduced to 0.2‰. These data suggest a beneficial effect of gentamicin in the prevention of postoperative endophthalmitis.
Previous studies have demonstrated that preoperative instillation of antibiotic solution, conjunctival sac irrigation and preoperative povidone-iodine disinfection of the conjunctival sac can significantly reduce the bacterial load in the surgical field [23]. However, it is impossible to maintain a sterile state in the surgical field during the whole procedures of surgery [24]. Bacteria colonized in the margin of eyelid, meibomian glands and conjunctival sac can spread to the surgical field or enter the anterior chamber through surgical instruments [25,26,27]. Perioperative use of antibiotics reduces the incidence of endophthalmitis after cataract surgery [28]. The type of antibiotic, the mode of use and the pharmacokinetic parameters of topical antibiotics can all affect the anti-bacterial outcome and bacterial spectrum in endophthalmitis after surgery [29, 30]. We also observed that the spectrum of pathogenic bacteria in endophthalmitis samples changed when gentamicin was present in the perfusion solution. Particularly, the proportion of Enterococcus strains showed a significant increase.
Perioperative instillation of fluoroquinolone is a common approach for preventing endophthalmitis after cataract surgery [31]. The concentration of different quinolone antibiotics in the anterior chamber can reach to 1–4 µg/ml [32,33,34,35]. To reduce endophthalmitis incidence, intracameral injection of cefuroxime, moxifloxacin and vancomycin in the surgical perfusion solution has been adopted in clinical practice. However, adverse reactions due to use of antibiotics are also a serious concern [36,37,38,39]. Gentamicin is a concentration-dependent antibiotic with superior bactericidal effect on Staphylococcus. Here, we reported that adding gentamicin to the perfusion solution could reduce cataract postoperative endophthalmitis incidence, and no obvious side effects were observed. When gentamicin is administered systemically, significant side effects can occur if Cmax exceeds 12 µg/mL [40, 41]. The safe concentration of gentamicin in the perfusion solution was much higher than the MIC90, suggesting that an excellent bactericidal effect on coagulase-negative pathogens such as Staphylococci strains. In this study, the drug sensitivity breakpoints of levofloxacin and gentamicin were 4 µg/mL and 80 µg/ml, respectively. Most pathogens (except 4 strains of Enterococci) were sensitive to 80 µg/mL gentamicin. One strain of MRSE and one strain of MRSA were detected in group B samples, however their MICs of gentamicin were lower than 80 µg/mL. This suggests that postoperative endophthalmitis can be caused by factors other than antibiotic precaution, such as the immune condition or intraocular pharmacokinetics of antibiotics.
The incidence of enterococcal endophthalmitis after cataract surgery tends to increase recently. Enterococci are more resistant to the fourth-generation fluoroquinolones than coagulase-negative Staphylococci [26, 42]. Aminoglycoside inactivating enzyme encoded by the aac(6')-aph(2'') gene can confer resistance to high concentrations of gentamicin [43]. In our study, we identified four strains of Enterococci which were highly resistant to high concentrations of gentamicin. Interestingly, the aac(6')-aph(2'') gene was detected in all four gentamicin-resistant strains. Thus, the application of gentamicin may serve as a selective pressure to facilitate the domination of strains harboring gentamicin-resistant genes.
Our studies have been limited by the numbers of pathogenic bacteria isolated in both groups. We reasoned that the use of different nutrient-rich culture methods may increase the recovery of fastidious pathogenic bacterial strains. In addition, the potential gentamicin-inactivating genes should be cloned and transferred to a sensitive strain to confirm its biological function.
In conclusion, the types and application mode of antibiotics in the perioperative period of cataract surgery affect the incidence of postoperative endophthalmitis and the spectrum of pathogenic bacteria. We reported that gentamicin at a safe concentration can reduce the incidence of endophthalmitis after cataract surgery. However, the presence of gentamicin may also serve as selective pressure to provide survival advantages of gentamicin-resistant Enterococci. Therefore, a combination of antibiotics with different modes of actions may minimize the chance of drug resistance, which warrants future clinical validation.
Data Availability
All data included in this study are available upon request by contact with the corresponding author.
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Ma W. designed this study and defined the intellectual content. Ma W. Hou G. and Wang J. acquired the data and analyzed the data. Liu T did the literature study. Liu T and Tian F. acquired the experimental data. Ma W. drafted the paper and Tian F revised the paper. All authors have read and approved the final paper.
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This study was approved by the ethic committee of Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital and written informed consent was obtained from all participants. All methods were carried out in accordance with relevant guidelines and regulations.
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Ma, W., Hou, G., Wang, J. et al. Evaluation of the effect of gentamicin in surgical perfusion solution on cataract postoperative endophthalmitis. BMC Ophthalmol 22, 410 (2022). https://doi.org/10.1186/s12886-022-02633-2
DOI: https://doi.org/10.1186/s12886-022-02633-2