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The characteristics of immune memory established in response to inactivated SARS-CoV-2 vaccines remains unclear. We determined the magnitude, quality and persistence of cellular and humoral memory responses up to 6 months after vaccination with BBV152/Covaxin. Here, we show that the quantity of vaccine-induced spike- and nucleoprotein-antibodies is comparable to that following natural infection and the antibodies are detectable up to 6 months. The RBD-specific antibodies decline in the range of 3 to 10-fold against the SARS-CoV-2 variants in the order of alpha (B.1.1.7) > delta (B.1.617.2) > beta (B.1.351), with no observed impact of gamma (P.1) and kappa (B.1.617.1) variant. We found that the vaccine induces memory B cells, similar to natural infection, which are impacted by virus variants in the same order as antibodies. The vaccine further induced antigen-specific functionally potent multi-cytokine expressing CD4+ T cells in ∼85% of the subjects, targeting spike and nucleoprotein of SARS-CoV-2. Marginal ∼1.3 fold-reduction was observed in vaccine-induced CD4+ T cells against the beta variant, with no significant impact of the alpha and the delta variants. The antigen-specific CD4+ T cells were populated in the central memory compartment and persisted up to 6 months of vaccination. Importantly the vaccine generated Tfh cells that are endowed with B cell help potential, similar to the Tfh cells induced after natural infection. Altogether, these findings establish that the inactivated virus vaccine BBV152 induces robust immune memory to SARS-CoV-2 and variants of concern, which persist for at least 6 months after vaccination. This study provides insight into the attributes of BBV152-elicited immune memory, and has implication for future vaccine development, guidance for use of inactivated virus vaccine, and booster immunization.
Competing Interest Statement
NG, AA are listed as inventor on procedure patent application no. 202111003148, submitted by National Institute of Immunology, that covers the use of T-cell qualitative assessment method for vaccine evaluation and adjuvant testing purposes. A.S. is a consultant for Gritstone Bio, Flow Pharma, Arcturus Therapeutics, ImmunoScape, CellCarta, Avalia, Moderna, Fortress and Repertoire. LJI has filed for patent protection for various aspects of T cell epitope and vaccine design work. All other authors declare no conflict of interest. Data and materials availability: All data are available in the main text or the extended data.
Funding Statement
This work was financially supported by the Science and Engineering Research Board, DST grant (IPA/2020/000077) to NG, Department of Biotechnology (DBT) grant (BT/PR30223/MED/2018) to NG and the core grant of National Institute of Immunology. COVID-19 Bioresource grant (BT/PR40401/BIOBANK/03.2020) to Translational Health Science and Technology Institute. Further support provided in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. 75N93021C00016 to A.S. and Contract No. 75N9301900065 to A.S, D.W.
Author Declarations
I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
The details of the IRB/oversight body that provided approval or exemption for the research described are given below:
The study protocols were approved by the Human Research Ethics Committees of National Institute of Immunology and the partnering institutions.
I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.
I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).
I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.
Data Availability
All data are available in the main text or the extended data


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The baseball players in the $300 million contract club have one obvious thing in common, but prior to this week's MLB Winter Meetings, they shared something else, too: They all put pen to paper in their 20s.
All 10 of MLB's $300 million hitters played at least two seasons of those deals in their 20s. But Aaron Judge, who reportedly has a nine-year, $360 million agreement in place with the New York Yankees, is about to Kool-Aid Man his way right through that perceived barrier.
Unsurprisingly, all of the $300 million deals in baseball history are recent and ongoing, the earliest being Giancarlo Stanton's extension signed in November 2014. Among them, you get a snapshot of what recent MLB front offices have viewed as super-elite players. And the overwhelming takeaway is that these sorts of contracts, nowadays, go to stars who are both great and young.
Fairly or unfairly, major deals for superstars in their fourth decade of life — Miguel Cabrera, Albert Pujols, Robinson Cano and (for somewhat different reasons) Alex Rodriguez — have been maligned as cautionary tales, identified as a metaphorical, dread-inducing species of contract called an "albatross." No hitter over 30 had bested Cabrera's eight-year, $248 million extension with the Detroit Tigers until Judge's reported pact with the Yankees on Wednesday. Anthony Rendon, who turned 30 in June of the first season of his $245 million deal with the Los Angeles Angels, is perhaps the closest thing to a spiritual successor.
What the intervening years have seen instead is a rush to identify and sign superstars at earlier and earlier ages, preferably (for teams) before they ever reach an open market where a bidding war might ensue. Since Cabrera's deal, MLB teams have combined a ruthless pursuit of efficiency with just enough life-changing money for the top talents, and extensions have become the norm for elite players. Mike Trout, Mookie Betts, Jose Ramirez, Francisco Lindor, Nolan Arenado, Jose Altuve: Those are the top six position players, by FanGraphs WAR, since Cabrera's contract began in 2016, and not one of them has ever been a free agent.
Seventh, though, is Judge. And by rejecting the Yankees' overture — a seven-year, $213.5 million extension — prior to 2022, he pressed baseball to grapple once again with the matter of an elite talent at a suboptimal age.
Younger, better, faster, stronger
MLB's labor structure, which keeps players under team control for their first six seasons of major-league service, has long led to situations in which stars are vastly underpaid in their 20s, then finally rewarded for past performance as their skills wane.
In most cases, the disappointment of highly paid stars underperforming overshadows any consideration for the unfair financial purgatory the system already subjected them to. Fans boo. Players feel the double-whammy of declining ability and mounting antipathy. Team owners browbeat and dismiss the GMs who negotiated the deals. Most everyone winds up unhappy.
So before we rocket ahead and begin conceiving of this deal in hindsight, remember that this bitter reality is brewed by the system, not the players caught up in it. None of them has a responsibility to sacrifice money to make everyone else feel better. Judge believed he was worth more than the $213.5 million the Yankees offered in spring 2022. Then he swung it into existence by belting 62 homers and letting the open market have the final say.
Unfortunately, though, there's one big, honking reason the Yankees of December 2022 committed $360 million to a soon-to-be-31-year-old: Because they didn't have a 25-year-old to give it to instead.
It's not difficult to process why teams have recently been working to sign elite stars to deals that cover, say, ages 25 to 35 instead of 30 to 40. Pre-free-agency deals for Betts, Lindor and others come with a lot of benefits even at huge total values. Namely, the structure can be more fitted to the team's liking when there's no bidding war involved, and there's a wider realistic window to achieve a justifying payoff — in the form of a World Series, a record chase, an MVP, whatever.
The early-career deals for Wander Franco, Julio Rodriguez and even Fernando Tatis Jr. show that thesis at its most extreme. You can call the Tatis deal a disaster for the Padres over his injuries and (repeated instances of) poor judgment if you want, but are you really certain you won't be proven dramatically wrong at any point before 2034?
The Yankees' real albatross
Judge's deal anticipates, at a fundamental level, a player worth about 5 Wins Above Replacement per season ($8 million per 1 WAR is a common shortcut for assessing value on the open market, though it often varies). Yet everyone knows it doesn't work quite that cleanly. He's capable of the extraordinary — his 2022 was worth 11.4 WAR per FanGraphs, his 2017 worth 8.7 WAR — but more often, he checks in right around that 5-WAR threshold.
Or, to be more precise, he has checked in around that threshold — past tense. But the aging curve for hitters is cruel, sapping peripheral skills such as baserunning and defense, which adds up and puts pressure on the bat to be even better … right as those hitting abilities start to dwindle as well.
It's difficult to envision Judge as anything but a homer-bashing titan after the previous year, but history says his days of world domination are indeed numbered. Since integration in 1947, 35 hitters have recorded three or more seasons of 5-plus WAR in their age-31 seasons and beyond, according to Baseball-Reference. But since Barry Bonds' last peak year in 2004, only three players have managed that feat: Adrian Beltre, Ichiro Suzuki and Ian Kinsler.
If you narrow the scope to hitters 6-foot-5 or taller, it's even bleaker: Since 1947, Dave Winfield and John Olerud put up two 5-WAR seasons apiece, Mark McGwire did it five times (potentially, of course, with the assistance of performance-enhancing drugs), and no one else has done it more than once.
There's no lesson there, just pure scarcity. The road ahead of Judge is depressingly difficult.
I'd bet Yankees GM Brian Cashman isn't expecting 39-year-old Judge — or even 36-year-old Judge — to be a five-win player. He and the Yankees' front office probably aren't even anticipating much more from Judge's 2023 to 2031 seasons than they were this spring — before the Bonds impersonation and the 62 homers and the whole "carrying them through the summer while the rest of the lineup took a nap" thing.
The Yankees are looking at 2023, and perhaps 2024, and acknowledging that the best, most direct way to keep their competitive window wide open — an annual imperative in the Bronx — involves asking Judge to hold it there as they attempt to incorporate younger prospects such as shortstop Anthony Volpe while maximizing the tenures of other expensive stars, such as ace Gerrit Cole and outfielder Giancarlo Stanton.
In terms of the Yankees' finances, Judge's astoundingly great 2022 — and the resulting leap from $213.5 million to $360 million — was a black swan event, an entirely unforeseeable campaign that might stick around as a different large, metaphorical bird, if you're into the shorthand for contracts that age poorly: an albatross.
The Yankees know how this works, though. Being the Yankees means they have to pony up in this moment — and that they have the money to do so. A little unpleasantness is the price of chasing a ringing achievement.
And Aaron Judge just showed how lucrative that can be.

subset: commoncrawl


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NBA executives rank Jalen Green among under 25 players
Houston Rockets fans are well aware of Jalen Green's talents. He has a preternatural ability to use his agility, balance, flexibility, and explosion to conjure open shots. As his handle and jump shot improve, it's only a matter of time before he joins the elite 25-points-per-game club. His scoring potential is special, and NBA executives have taken notice.
NBA executives believe in Jalen Green
Hoopshype polled 15 NBA executives, asking them to rank their top-five players under 25 years old to build around, and Jalen Green tied with 2021 number one overall pick Cade Cunningham as the tenth-best young building block.
The poll, unsurprisingly, had Luka Doncic ranked first, followed by, in order; Jayson Tatum, Ja Morant, Evan Mobley, Anthony Edwards, Zion Williamson, Scottie Barnes, LaMelo Ball, Trae Young, Darius Garland, Jalen Green, Cade Cunningham, Shai Gilgeous-Alexander, and Tyrese Haliburton.
The company Jalen Green is keeping should have Rockets fans excited. Being in the same class as some of the game's best young stars is no easy feat, and he's by far the youngest player. However, the speed at which he rose up these rankings is nothing short of spectacular.
Jalen Green's impressive turnaround
Hoopshype conducted a similar exercise in January of 2022, and Green wasn't even ranked. General managers' lack of faith should be viewed as a slight either, as his career got off to a rocky start.
In Green's first 33 games, he averaged 14.2 points per game on 37.4% shooting. The flashes of greatness were always there, but when the results are that bad, you're less of a building block and more of a wrecking ball.
However, Green turned it on as the season progressed. Over his final 34 games, he torched the league, averaging 20.3 points per game on 46.7% shooting. For most players, that would represent a career stretch. For Jalen Green, it was just him figuring out the league.
There remains a surprisingly large contingent in the NBA media who remain skeptical of Jalen Green, but there's a reason they're in the media and not in a front office. The people whose livelihood depends on player evaluation know what Rockets fans know. Jalen Green is the real deal. With a strong showing in 2022-23, there's no telling how high he could rise.


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This morning, the Federal Circuit issued four precedential opinions: two in patent cases, one in a Merit Systems Protection Board case, and one involving an appeal of a district court's order transferring a case to the Court of Federal Claims. Also, late yesterday the Federal Circuit issued a nonprecedential order in a patent case granting a petition for a writ of mandamus and ordering a district court within 30 days to issue a ruling on a motion to transfer. Here are the introductions to the opinions and text from the order.
Uniloc 2017 LLC v. Facebook Inc. (Precedential)
Uniloc 2017 LLC (Uniloc) appeals from two consolidated inter partes review (IPR) decisions of the Patent Trial and Appeal Board (Board) finding unpatentable claims 1– 8 and claims 9–12, 14–17, 25 and 26 of U.S. Patent No. 8,995,433 ('433 patent) as obvious.
Foremost at issue in this case is whether 35 U.S.C. § 314(d)'s "No Appeal" provision bars this court's review of the Board's conclusion that under § 315(e)(1) a petitioner is not estopped from maintaining the IPR proceeding before it. Under the circumstances of this case, we hold that § 314(d) does not preclude this court from reviewing the Board's § 315(e)(1) estoppel decision. We further conclude that the Board did not err in finding that LG Electronics Inc. (LG) is not estopped from maintaining its IPR challenge to claims 1–8 and that Facebook and WhatsApp (collectively, Facebook) are not estopped from challenging claim 7. As to the Board's obviousness conclusions, we see no error in the Board's unpatentability findings. Accordingly, we affirm.
Brenner v. Department of Veterans Affairs (Precedential)
Petitioner, Lawrence Brenner, seeks review of a final decision of the Merit Systems Protection Board ("MSPB") affirming the U.S. Department of Veterans Affairs' ("VA") decision to remove Mr. Brenner from his position as General Attorney, GS-14, with the VA's Collections National Practice Group ("CNPG") pursuant to 38 U.S.C. § 714, enacted as part of the Department of Veterans Affairs Accountability and Whistleblower Protection Act of 2017 ("the Act"), Pub. L. No. 115–41, 131 Stat. 862. See Brenner v. Dep't of Veterans Affairs, No. NY-0714-19-0007-I-1, 2019 WL 1315751 (M.S.P.B. Mar. 18, 2019) (J.A. 7–54).
We have jurisdiction pursuant to 28 U.S.C. § 1295(a)(9). We vacate and remand.
Taylor Energy Company, LLC v. Department of the Interior (Precedential)
Appellants, United States Department of the Interior, et al. (collectively, "Interior"), appeal the decision of the United States District Court for the Eastern District of Louisiana, transferring this case to the United States Court of Federal Claims ("Claims Court"). Order, Taylor Energy Co. LLC v. United States Dep't of Interior, No. 18- 14065 (E.D. La. Mar. 31, 2020), ECF No. 71; J.A. 1–2 (Transfer Order). Because we hold that the Claims Court does not have subject matter jurisdiction over this case, we reverse and remand to the district court for further proceedings.
Edgewell Personal Care Brands, LLC v. Munchkin, Inc. (Precedential)
Edgewell Personal Care Brands, LLC, and International Refills Company, Ltd. (collectively, Edgewell) sued Munchkin, Inc. in the Central District of California for infringement of claims of U.S. Patent Nos. 8,899,420 and 6,974,029. Edgewell manufactures and sells the Diaper Genie, which is a diaper pail system that has two main components: (i) a pail for collection of soiled diapers; and (ii) a replaceable cassette that is placed inside the pail and forms a wrapper around the soiled diapers. The '420 patent and the '029 patent relate to alleged improvements in the cassette design. See, e.g., '420 patent at 2:18–32; '029 patent at Abstract. As relevant to this appeal, Edgewell accused Munchkin's Second and Third Generation refill cassettes, which Munchkin marketed as being compatible with Edgewell's Diaper Genie-branded diaper pails, of infringement. J.A. 18474.
In February 2019, the district court issued a claim construction order, construing terms of both the '420 patent and the '029 patent. Based on those constructions, Edgewell continued to assert literal infringement of the '420 patent, but only asserted infringement under the doctrine of equivalents for the '029 patent. Munchkin moved for, and the district court granted, summary judgment of noninfringement of both patents. See Edgewell Personal Care Brands, LLC v. Munchkin, Inc., No. 18-3005-PSG, 2019 WL 7165917 (C.D. Cal. Oct. 16, 2019) (Summary Judgment Decision). Edgewell appeals. We have jurisdiction under 28 U.S.C. § 1295(a)(1). For the reasons discussed below, we vacate-in-part, reverse-in-part, and remand.
In re Tracfone Wireless, Inc. (Nonprecedential Order)
TracFone Wireless, Inc. petitions for a writ of mandamus directing the United States District Court for the Western District of Texas to transfer this case to the United States District Court for the Southern District of Florida, or in the alternative, to direct the district court to stay proceedings until such time the district court rules on TracFone's motion to transfer. Precis Group LLC responds and takes "no position regarding the relief requested."
* * *
The Petition for Writ of Mandamus is granted and the district court is ordered to issue its ruling on the motion to transfer within 30 days from the issuance of this order, and to provide a reasoned basis for its ruling that is capable of meaningful appellate review. See SK hynix, 835 F. App'x at 601. We also order that all proceedings in the case are stayed until further notice. We do not address the merits of TracFone's motions, leaving those decisions to be made by the district court in the first instance. But we remind the lower court that any familiarity that it has gained with the underlying litigation due to the progress of the case since the filing of the complaint is irrelevant when considering the transfer motion and should not color its decision. See Google, 2015 WL 5294800 at *2.


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words by niall roeder
When you hear the name, Claude Monet, you probably don't think of Masterchef, The Naked Chef or Gordon Ramsey putting two pieces of bread against a poor girl's head and making her admit she's an "idiot sandwich". But it turns out that the father of French Impressionism could actually be the original celebrity chef. Move over Colombaris, get out of here Oliver, Monet is dans la maison.
Art historian, Dr. Wendy Joyce of Victoria University and Executive Chef, Laurent Loudeac are the brains behind Dine with Monet – a feasting experience inspired by Monet's two-acre kitchen garden and the sixty-odd recipes from the cookbook, Monet's Palate – The Artist and His Kitchen Garden at Giverny.
If an immersion in history, art and traditional French cuisine makes your kettle boil, then this Wellington on a Plate event is for you, my hungry and sophisticated friend.
Set amongst the extensive art collection of Hippopotamus (the country's largest privately owned art collection), the expertly-curated five course degustation will take art-loving foodies on a journey to late 19th Century France to explore the connections between painting and gastronomy.
"Monet's passion for food was expressed through his beloved garden. Guests at this event will enjoy bountiful New Zealand produce and traditional French cooking" – Executive Chef, Laurent Loudeac
Who knew Monet was an undercover foodie?
Wellington on a Plate is going to be two big, tasty weeks. If you're looking somewhere to crash, QT Museum Wellington has a festival accommodation offer that will let you enjoy your food coma in style.
Dine with Monet will take place August 23 2018, 7pm – 11:30pm at Hippopotamus.
Tickets can be purchased here.
QT Social
Feeling a little social? Follow QT


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Please add profiles of those who were born, lived or died in Columbia, Missouri.
Official Website
Columbia is the county seat of Boone County.
As a Midwestern college town, Columbia has a reputation for progressive politics, persuasive journalism, and public art. The tripartite establishment of Stephens College (1833), the University of Missouri (1839), and Columbia College (1851), which surround the city's Downtown to the east, south, and north, has made the city a center of learning. At its center is 8th Street, also known as the Avenue of the Columns, which connects Francis Quadrangle and Jesse Hall to the Boone County Courthouse and the City Hall. Originally an agricultural town, the cultivation of the mind is Columbia's chief economic concern today. Never a major center of manufacturing, the city also depends on healthcare, insurance, and technology businesses. Companies such as Shelter Insurance, Carfax, and Slackers CDs and Games, were founded in the city. Cultural institutions include the State Historical Society of Missouri, the Museum of Art and Archaeology, and the annual True/False Film Festival. The Missouri Tigers, the state's only major college athletic program, play football at Faurot Field and basketball at Mizzou Arena as members of the rigorous Southeastern Conference.
The city rests upon the forested hills and rolling prairies of Mid-Missouri, near the Missouri River valley, where the Ozark Mountains begin to transform into plains and savanna. Limestone forms bluffs and glades while rain dissolves the bedrock, creating caves and springs which water the Hinkson, Roche Perche, and Bonne Femme creeks. Surrounding the city, Rock Bridge Memorial State Park, Mark Twain National Forest, and Big Muddy National Fish and Wildlife Refuge form a greenbelt preserving sensitive and rare environments.
The first humans who entered the area at least twelve thousand years ago were nomadic hunters. Later, woodland tribes lived in villages along waterways and built mounds in high places. The Osage and Missouria nations were expelled by the exploration of French traders and the rapid settlement of American pioneers. The latter arrived by the Boone's Lick Road and hailed from the culture of the Upland South, especially Virginia, Kentucky, and Tennessee. From 1812 on the Boonslick area would play a pivotal role in Missouri's early history and the nation's westward expansion. German, Irish, and other European immigrants soon joined. The modern populace is unusually diverse, over eight percent foreign-born. While White and Black remain the largest ethnicities, people of Asian descent are now the third-largest group. The city has been called the "Athens of Missouri" for its classic beauty and educational emphasis, but is more commonly called "CoMo".
The city benefited from being a stagecoach stop of the Santa Fe and Oregon trails, and later from the Missouri–Kansas–Texas Railroad. In 1822, William Jewell set up the first hospital. In 1830, the first newspaper began; in 1832, the first theater in the state was opened; and in 1835, the state's first agricultural fair was held.
In 2017, Columbia was in the path of totality for the Solar eclipse of August 21, 2017.


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Vignelli Center Lecture: Alan Heller
Event Image
Lecture title: "Good Design at Affordable Prices"
Alan Heller graduated from The New School in New York with a BA in Economics. Since founding Heller, Inc in 1970, he has been dedicated to selling well-designed products at competitive prices.
He has worked with the world's most iconic designers, including Massimo and Lella Vignelli. He offered houseware product lines for Gladys Goose and Starck's Excalibur.
Heller's first furniture design, the Bellini Chair, won the 1998 Compasso d'Oro, Italy's most prestigious design award. His ErgoErgo design for seating revolutionized the genre. Alan Heller was named the youngest director of the National Housewares Manufacturers Association.
Event Snapshot
When and Where
Open to the Public
Interpreter Requested?


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Sleep apnea is a serious and often undiagnosed health condition that affects a large number of men worldwide. Despite its prevalence, this disorder often goes unnoticed, disregarded, or even dismissed as a mere snoring problem. However, the ramifications of sleep apnea extend far beyond a simple nuisance; it can lead to a wide range of health complications if left untreated.
Sleep apnea is characterized by repeated pauses in breathing during sleep. These pauses, known as apneas, can last from a few seconds to minutes, severely disrupting the sleep cycle. This interruption in breathing can occur dozens or even hundreds of times throughout the night, leaving sufferers feeling tired and fatigued during the day.
While sleep apnea can affect anyone, men are particularly prone to this condition. Studies have shown that men are twice as likely as women to develop sleep apnea, especially as they age. This increased risk is often attributed to factors such as obesity, a larger neck circumference, and hormonal differences.
One of the most concerning aspects of sleep apnea is its association with numerous health complications. Untreated sleep apnea has been linked to hypertension, cardiovascular disease, stroke, and diabetes. Additionally, it can contribute to weight gain, depression, memory problems, and reduced libido. Therefore, it is crucial for men to recognize the significance of sleep apnea and seek appropriate treatment.
Despite its potentially devastating consequences, sleep apnea is frequently overlooked or dismissed. Many individuals dismiss their symptoms as normal fatigue or attribute them to stress. Furthermore, societal expectations often discourage men from acknowledging their health issues, creating a culture where men tend to suffer in silence.
Recognizing the signs and symptoms of sleep apnea is the first step towards addressing this widespread men's health crisis. Some common indicators include loud snoring, excessive daytime sleepiness, morning headaches, irritability, and difficulty concentrating. However, it is essential to remember that not everyone with sleep apnea snores, making diagnosis even more challenging.
If you suspect you have sleep apnea, consulting a healthcare professional is crucial. There are various diagnostic tools available, including sleep studies conducted in a sleep laboratory or the convenience of home-based sleep testing. These tests can determine the severity of your condition and help professionals develop an appropriate treatment plan.
Treatment options for sleep apnea range from lifestyle changes to medical interventions. Losing weight, regular exercise, and avoiding alcohol and sedatives before sleep can significantly alleviate the symptoms of mild to moderate sleep apnea. In more severe cases, continuous positive airway pressure (CPAP) therapy is often prescribed. This treatment involves wearing a mask that delivers a constant flow of air to keep the airway open during sleep.
In conclusion, sleep apnea is a common and often overlooked health crisis that affects men around the world. This disorder can have far-reaching consequences, affecting not only sleep quality but also overall health and well-being. Recognizing the signs and symptoms and seeking appropriate medical intervention is paramount in addressing this issue and ensuring a healthier future for men everywhere. It's time to break the silence surrounding sleep apnea and take action towards better sleep and improved men's health.


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Do you wish to purchase a NNN (triple-net) property that is on the market? If so, your luck has changed. A great investment option, NNN for Sale – Net Lease World has several advantages. Through the 1031 exchange mechanism, they also offer tax benefits in addition to a consistent income source. What NNN properties are, how to purchase them, and the advantages of purchasing 1031 NNN properties for sale will all be covered in this blog post.
NNN Properties: What Are They?
An investment in commercial real estate that is leased to a tenant on a triple-net basis is known as a NNN property. Therefore, all costs related to the rental property, such as taxes, insurance, and upkeep, fall under the responsibility of the tenant. The tenant typically pays a greater rent than they would for a regular commercial lease in exchange for taking on these obligations.
Why Invest in NNN Properties
Several factors influence why investors could decide to buy 1031 nnn properties for sale. They first offer a consistent revenue stream independent of market changes or the success of other assets. Second, investors don't have to worry about unforeseen costs or maintenance concerns because the renter is in charge of all costs related to the property. Finally, leverage can be used to buy NNN properties through different financing choices.
How to Purchase NNN Investment Properties
There are various procedures you should follow before buying NNN properties to make sure that your choice is well-informed. To start with, do some market research in your area to figure out what kind of home would suit your wants and budget the most. The next step is to speak with a qualified real estate lawyer who can give you advice on any potential legal concerns you may have with the acquisition. Finally, you should work with a knowledgeable real estate agent who can guide you in finding appropriate properties and advocate on your behalf during negotiations.
Advantages of Purchasing 1031 NNN Properties
The fact that 1031 NNN properties for sale offer tax savings through the 1031 exchange scheme is one of their main advantages. When they sell an investment property and reinvest in another like-kind property within 180 days of the selling date, investors can use the 1031 exchange to postpone paying capital gains taxes. Over time, this can save taxpayers a sizable amount of money on taxes while also enabling investors to get the most profit from their assets. Additionally, by enabling investors to distribute their wealth across several properties in various markets or asset classes, 1031 exchanges can be utilized to diversify investments.
A fantastic option to invest in commercial real estate and benefit from tax savings provided by the 1031 exchange program is to purchase 1031 NNN properties that are for sale. It's crucial to conduct a study before buying these kinds of assets and to speak with experts who can help direct you through the procedure. You can uncover a great investment option that will give you a reliable income and long-term capital growth with proper preparation and research.


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Prince william and kate make surprise appearance on big night in. Add the shows you like to a watchlist and let the site take it from there. The saga of william and kate is one thing above all else. The royal wedding on april the 29th, 2011, was a grand occasion, and millions of people all around the world watched it. Prince william and kate middleton defied all odds to forge a storybook romance amidst the scandals. Everyday low prices and free delivery on eligible orders. His 8 year courtship with kate middleton is explored, as the world anticipates another royal wedding.
Now the sound of wedding bells is about to ring loud and clear for the joyful couple. The prince later switches to a geography course, but the pair remain close. Royal mail issued this commemorative stamp of the royal wedding on 29th. The book is scheduled for publication in february 2011. But their love story began long before they made hearts stop at westminster abbey. A royal love story takes you behind the scenes and reveals how kate harbored a crush on william since her days at marlborough, how they met at the university, became friends and then lovers, and.
William, second in line to the throne, will marry in london next spring or summer and live in north wales, where he is serving with the raf. A royal love story has glamour the paps, the palaces and parades but at its heart its an entertaining, warm and insightful look at the nations favourite couple. Explore audibles collection of free sleep and relaxation audio experiences. All content included on our site, such as text, images, digital downloads and other, is the property of its content suppliers and protected by us and international laws. Kate diggory fell in love with william arthur weasley when they met for the third task of the triwizard tournament to support their families. The story so far since catherine elizabeth middleton first caught prince williams eye at st andrews university, we have watched their love story unfold like an upmarket soap. Prince william and kate middleton begin a royal romance after meeting at. Written by the suns royal correspondent, it features 150 beautiful photographs and is the perfect keepsake of this memorable, onceinalifetime event. Prince william and kate middleton have had a fairytale romance since meeting as students over a decade ago, but theyve had some challenges along the way. Prince william is to marry longterm girlfriend kate middleton next year, clarence house has announced. When prince william knew kate middleton was the one.
The echoes of a royal wedding from an earlier era are difficult to ignore but the snap also reflects the differences between them and charles and diana. The movie also features jane alexander as queen elizabeth ii and victor garber as prince charles, prince of wales. William and kate a royal love story christopher andersen. Once upon a time, a 20yearold girl named kate middleton caught the eye of a 19yearold boy named william, who just so happened to be the eldest son of the late princess diana and second in line of succession to the british royal throne, and that was that. A royal love story reveals the sometimes glamorous, and sometimes very ordinary, background to one of the most talked about romances of the 21st century. The movie is the first of two unrelated american television films about the relationship between prince william and catherine kate middleton now the duke and duchess of cambridge, directed by mark rosman and written by nancey silvers. I put it to william, particularly, that if you find someone you love in life, you must hang on. Hrh prince william, future king of the united kingdom and kate middleton, an extraordinary girl from. Having met a few times before, they fell in love whilst studying at st. A royal love story updated the courtship of kate middleton and prince william, son of prince charles and princess diana, predicts another royal wedding in the making.
Her natural shyness and nomake up face and simplicity is what attracted william most. Prince william and kate middletons fairytale romance is the greatest love story of the century, with a happy ending to come a royal wedding that will trul. A royal love story next episode air date and your others favorite tv shows. Prince william and kate middleton defied all odds to forge a storybook romance amide the scandals. The film was a ratings success, despite the negative reception from critics.
A royal love story united kingdom 2011 47 minutes awaiting the lavish royal wedding of prince william and kate middleton, this documentary focuses on their love story and the royal romance that is yet to come. Part modern fairy tale, part royal love story, kate. In part two, the entire world waits in anticipation of the wedding as the new peoples princess kate prepares to take her vows. This is the unrivalled inside story of the most talked about royal couple of the millennium.
William and kate a royal love story christopher andersen william and kate a royal the marriage of prince william and kate middleton propelled the british royal family to a level of popularity that has rarely been seen. The plot summary provided by internet movie database is, chronicles prince william and kate middleton, as young. A royal love story by the sun available from rakuten kobo. A royal romance is an american 2011 television movie that stars alice st.
The love story of william and kate in this special documentary that uncovers how they met, fell in love and how they got to where they are now. The duchess and prince william fell in love at university of st andrews. He is also the same photographer who worked with princess diana in her vanity fair cover in 1997. Includes bibliographical references prince william and kate middleton defied all odds to forge a storybook romance amide the scandals, power struggles, tragedies, and general dysfunction that are the hallmarks of britains royal family. The official royal wedding album suggests kate and williams future will be. The true story of prince william and kate middletons fairytale romanceand the royal wedding that will capture the hearts of people around the world. This remarkable young couple has gained the affections of nations across the globe and their fairytale wedding prompted an. Christopher andersen is the critically acclaimed author of sixteen new york times bestsellers which have been translated into more than twentyfive languages worldwide. He then follows their life stories until they intersect, and goes on to recount their tenyear relationship and eventual marriage. Clair as catherine middleton and dan amboyer as prince william of wales.
A royal love story by christopher andersen free download as pdf file. From the bestselling author of william and harry and renowned royal family news. William and kate book by christopher andersen official publisher. Mar 20, 2015 happy 4th anniversay to the royal couple. Two of his booksthe day diana died and the day john died about jfk jr.
Added to their long list of admirers from this industry is none other than mario testino, the artist who photographed the royal family during the christening of princess charlotte. The royal family ebook by penguin books ltd rakuten kobo. On april 29, 2011, prince william and kate middleton, his commoner bride, were married in a fairy tale wedding watched by 2 billion and celebrated around the globe. He was the boy who would one day be king, and she the middleclass girl who had harbored a crush on him pdf. A royal love story, christopher anderson explores the individual life stories of william, prince of wales and kate middleton, a commoner. Christopher andersen is the critically acclaimed author of fifteen new york times bestsellers which have been translated into more than twentyfive languages worldwide. Prince william and kate middleton were married seven years ago, in a televised spectacle that launched a thousand longsleeved wedding dresses. The love story begins at st andrews university, where william and kate are both studying art history. Prince william and kate make surprise appearance on big. Prince william and kate middleton meet at st andrews university but what will happen when they begin to fall in love.
A royal love story by christopher andersen in chm, fb2, fb3 download ebook. After rekindling their contact, kate was recommended to be included in the order of the phoenix. For more on kate and williams 17yearrelationship and the fairytale romances of your favourite royals, pick up a copy of the who collectors edition of greatest royal love stories. First of all was their engagement in november 2010. This level is suitable for students who have been learning english for at least two years.
Prince william and kate middletons fairytale romance is the greatest. Prince william and kate middleton never cease to make a splash with the members of the media. The people magazine edition will have free mcdonalds egg white delights mcmuffins coupons on page this. What william and kates adorable grumpy flower girl looks like now. Kate middleton and prince william on the day of their graduation ceremony at university of st andrews on june 23, 2005. The love story of prince william and kate middleton, which will culminate april 29, 2011 in the biggest royal wedding since charles and diana, chronicles the pair as young students at st.
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Evanescence singer Amy Lee has released her cover version of the Led Zeppelin classic 'Going To California' via her newly launched YouTube channel. The video can be watched below.
Says Lee about her decision to cover 'Going To California': "This song is a classic that I've loved for as long as I can remember. It puts me at peace.
"My friend and manager, Jordan, had recorded the instrumentation for fun and when I heard it a few months ago, I knew instantly that I had to sing on it.
"Listening to mommy sing usually helps get Jack into that elusive sleepy place, and this song has been a regular rotation nap-time hit around our house this fall.
"As I was preparing for the November Evanescence shows, I just really wanted a moment like this in our set. So I showed this version to Troy, who made it a personal challenge to master a finger-picking-based song, which was outside his comfort zone (not that you could tell — he sounded amazing!).
"We had so much fun playing it live!
"It's a pleasure to sing a song publicly that is such a part of who I am offstage — my roots, the style of music that we always played around my house when I was growing up, and still at every big family gathering, singing and playing music with my dad.
"Hope you enjoy it!"
Lee previously released her covers of U2's 'With or Without You' and Portishead's 'It's A Fire'.
Evanescence recently parted ways with guitarist Terry Balsamo and replaced him with Germany's Jen Majura.
Evanescence re-emerged last month after a three-year hiatus with select, intimate shows in Nashville, Dallas and Los Angeles. The influential, Grammy-winning band had not performed live since November of 2012.


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Malaysia-based ERS Energy Group has selected Chinese solar module maker Seraphim to supply solar modules for its 300 MW solar plant which located in Zambales province, Philippines.
Seraphim has chiefly agreed to supply 550/555W modules. The modules use multi-busbar cell technology, resulting in lower internal losses and a reduced risk of micro cracks. This strengthens power generation efficiency and lowers the balance of system costs, according to the company.
The supply of the solar module is expected to start in the Q3 of 2023 and will be completed by the Q2 of 2024.
Seraphim global sales vice-president Insan Boy said: "We believe that our close collaboration with ERS will help us achieve our sustainable development goals in clean energy and bring positive impacts to the economy, environment and social development of the Philippines and the local communities."
"We have successfully completed several power station supply collaborations with Seraphim in the past. We are impressed with their outstanding component quality and performance, which is why we will continue to work with Seraphim to jointly promote the development of the solar energy market in the Philippines," said Jonathan Kan, Managing Director of ERS Group.
Seraphim has been present on the Philippines market since 2016. In July of 2022, the company signed a memorandum of understanding (MoU) with Resolar, a Luxembourg-based energy company, to supply 1 GW of solar modules during 2023.
The MoU was part of the EU's REPowerEU plan, which aims to expedite the clean energy transition. The Chinese firm also indicated that it has delivered 20 GW of PV products globally.


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Multiparty Activism in Uganda: The Experience of National Resistance Movement and National Unity Platform
Show full item recordAbstract
Different involvement motivations drive people into political actions. This study aimed to understand what, how, and why party members were motivated into political party activism. The focus was on the involvement motivations of the members of the new political party named National Unity Platform (NUP) and the incumbent ruling National Resistance (NRM) party. The study used a qualitative literature research strategy where qualitative secondary and primary data were collected. The secondary data involved a review of several relevant peer-reviewed journal articles, chapters in books, newspaper reports, and other documents reflecting the concept of party activism. We collected field data from twenty-four respondents using in-depth interviews. The field notes were transcribed and thematically analyzed using content analysis methods. The purposive sampling technique was used to select eighteen respondents and six respondents were identified and selected using the snowball sampling technique. The study found that party activism emerged out of various incentives, such as political events, slogans, ideology, political rivalry, and family exposure was important in the construction of civic competence. These findings suggest that political parties should involve and expose their members to different political experiences. Based on the analysis of these findings, the study concluded that many factors serve as incentives for political party activism.
- Humanities and the Arts [170]


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All Eminem lyrics in one place: Music to Be Murdered By, Kamikaze, Revival, The Marshall Mathers LP 2, Recovery, Relapse, Encore, The Eminem Show, The Marshall Mathers LP, The Slim Shady LP, The Slim Shady EP, Infinite and more…
Eminem: Relapse Lyrics
- Paul (skit)
- Stay Wide Awake
- Old Time's Sake (feat. Dr. Dre)
- Must Be the Ganja
- Mr. Mathers
- Deja Vu
- Beautiful
- Crack a Bottle (feat. Dre, 50 Cent)
- Steve Berman (skit)
- Underground
Eminem: Encore Lyrics
The Eminem Show Lyrics
The Marshall Mathers LP Lyrics
The Slim Shady LP Lyrics
Other Eminem Lyrics
Due to a high demand for Eminem lyrics we are doing our best to make them all available here for you. Check back soon for even more Eminem lyrics which are being gathered and will be published in due time. Some of the lyrics have been submitted by our visitors, so should you find any major mistakes, please let us know.
Eminem Relapse – Lyrics
Eminem Encore – Lyrics
Eminem – Albums


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El Paso Corp. will delay the release of its fourth quarter 2003 earnings indefinitely because it will probably have to restate its results, according to the company. On February 17, the energy giant had revised its estimate of proven natural gas and oil reserves downward by the equivalent of about 1.8 trillion cubic feet.
The total amount of the estimate revision will not change, the company stressed. However, since El Paso's revision announcement, the company has been reviewing whether parts of the revision should be applied to previous years. That would cause a restatement of those years' financial statements and related supplemental oil and gas reserve disclosures.
As a result of El Paso's internal reviews, as well as the independent review of its audit committee, the company will restate its financial statements as well as those of El Paso CGP Co. and El Paso Production Holding Co., according to an El Paso spokesperson. The company also warned that investors should not rely on previously filed reports until further notice.
El Paso is not the only energy company to admit that it has overstated its estimate of proven reserves. Earlier this year, Royal Dutch/Shell Group stunned investors when it said it overstated reserves by about 20 percent.
According to Wednesday's New York Times, one month before Royal Dutch/Shell cut its reserves estimate, it concluded that a number of its biggest competitors, including Exxon Mobil, had more conservative accounting of their reserves.


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Start: Jun 28, 2020 11:00AM EDT
The estate of renowned anthropologists and food historians Michael and Sophie Coe of New Haven, CT. With additions for from various estates.
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Jul 29, 2019
Jul 26, 2019
Jul 15, 2019
Listen in today as we get the discussion answering Marissa's question at the end of Part I of this two part episode. We are listening in to Aaron and his friends, giving a unique point of view on the military from a soldier's perspective. And if you didn't catch Part I of this episode, be sure to go back...
Jul 11, 2019


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This sweet little jacket features pink leopard prints. Made with pre-shrunk 100% cotton fabric. Velcro hook and loop tape at the neck and body closures make the jacket adjustable while keeping kitty safely secure.When fully overlapped, the neck measures about 8 inches and approximately 10 inches just behind the front legs.
Love Me in Pink Leopard Print - Itty Bitty Jacket


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Six injured in I-20 wreck
Published 2:50 pm Thursday, May 16, 2019
Six people were injured, with three of those being transported to Merit Health River Region for treatment, following a Thursday afternoon wreck on Interstate 20 westbound.
The wreck, which happened after 2:30 p.m. Thursday, appears to be the result of a vehicle traveling the wrong way on the interstate.
Witnesses said a white sedan went down the off ramp on Halls Ferry Road and began traveling east on westbound I-20. It traveled all the way to the Wisconsin Avenue overpass before it collided head on with a grey sedan. An 18-wheeler and another vehicle were also caught up in the wreck.
After the collision, the white sedan appeared to speed away backward, going down the embankment between the interstate and North Frontage Road, where it came to rest in the ditch.
While emergency officials responded, motorists raced to check on those injured in the accident, which included the drivers of both the white and grey sedans. Traffic along the interstate was also shut down because of the accident, leading to lengthy traffic back-ups and delays.
Chief Craig Danczyk with the Vicksburg Fire Department said first responders attended to six individuals injured in the wreck. Three of those were transported to Merit Health River Region, while three others refused treatment.


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According to the Kaon Lin tradition of Chinese bimill culture, the god Kuan Lon, the only deity who lives in a canteen, allows a human being to enjoy clairvoyance fourteen times in a lifetime.
Faemino and Tired go through the Kaon Lin tradition of the bimillennial Chinese culture, like many others, and maintain that fourteen are few and that they are already seventeen.
This new show is, without a doubt, the most groundbreaking of his career. They abandon the wisdom that has always accompanied them in their career and launch themselves without a parachute into a half-full pool, as an optimist would say. They gallop at last on a runaway horse and shed any patina of sanity. [These are all metaphors whose function is to fill]
What is evident in 17 TIMES is that Faemino and Tired always do what they want and now, because of their age, with more reason.
We hope they laugh, which is what they are looking for.
25/22/18 €


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Wisconsin Voter ID Law Re-Instated by Appeals Court
Just ahead of the 2014 elections, a federal appeals in Wisconsin approved the implementation of the state's voter ID law.
The three-judge panel of the U.S. Court of Appeals for the 7th Circuit ruled that the Badger State could implement its voter ID law while the courts hear cases over the constitutionality of the law.
But the appeals court decided that the state had such a good case that there was no longer any reason to hold up the law.
"The panel has concluded that the state's probability of success on the merits of this appeal is sufficiently great that the state should be allowed to implement its law," said the ruling.
The appeals court ruling means that the voter ID law will be in force for the November 2014 elections...
The following IDs will be acceptable for voting in November.
- Wisconsin driver's license, even if driving privileges are revoked or suspended.
- Wisconsin identification card issued by the Department of Transportation.
- Military ID card issued by a U.S. uniformed service.
- U.S. passport.
- Certificate of naturalization issued within two years of the election.
- A driving receipt issued by Wisconsin DOT, which is valid for 60 days.
- An identification card receipt issued by Wisconsin DOT, which is valid for 60 days.
- An identification card issued by a federally recognized Indian tribe in Wisconsin.
- A photo identification card issued by a Wisconsin accredited university or college that says the date it was issued, bears the student's signature and is good for only two years. Students also must present a separate document that proves enrollment.


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Vintage suede and fur trimmed mid length jacket fits like a small, brand reads highlander. One repair made, button replaced, mismatched but blends in. Please reach out via email@example.com if you would like more photos or information. Found items are final sale.


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Minymaku Kutju Tjukurpa. Women's Business Manual. Standard Treatment Manual for Women's Business in Central Australia
Alice Springs, Congress Alukura and Nganampa Health Council Inc, July 1994 (second edition)/ 1990.
Octavo; colour pictorial papered binder and spiral binding with chapter tabs; a fine copy.
'... aims to provide standard management protocols for health staff working with Aboriginal women in Central Australia'.
Item #128460
Price (AUD):