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Best 2-Person Soaker Tubs: 7 Picks for Luxury and Comfort in 2022
When it comes to bathtubs, 2-person soaker tubs offer spacious and significant comfort. While it may seem like an unnecessary luxury for most households, when compared to the average span of time they're kept, they're definitely worth their price. Unlike traditional bathtubs, 2-person soaker tubs are more convenient for large families with toddlers.
These tubs are perfect for shared relaxation and for unwinding with someone you care about, with a few scented candles and air jets (which you can add on) they offer users spa-like treatment at the comfort of your home. While there are several different options out there for bathtubs, selecting a 2-person tub ensures you have comfort and luxury that will last a long time.7 Top Two-Person Soaker Tubs
- 62" Degrasse Acrylic Oval Freestanding Tub With Insulation
- Burney Acrylic Freestanding Tub With Insulation
- Asher Acrylic Rectangular Freestanding Tub With Insulation
- Sutor Acrylic Freestanding Tub
- Hartland Resin Freestanding Tub
- 61" Tipton Acrylic Round Soaking Freestanding Tub with Integral Drain
- 72" Vista Copper Double-Slipper Roll-Top Tub with Pedestal
Best 2 Person Soaker Tubs - Top 7 Picks in 2022
1. 62" Degrasse Acrylic Oval Freestanding Tub With Insulation
2 person soaker tubs are the epitome of luxury, and this acrylic free-standing tub from Degrasse has an appearance to back it up. With a sleek, modern design, this bathtub requires you to use free-standing faucets.
While this bathtub does not come with faucet holes, it does have an impressive 57-gallon capacity. The bathtub comes with foam insulation for heat retention, and an integral waste and overflow feature to prevent water from overflowing.
Coming at an impressive $850, this bathtub is a premium option two-person soaker tub at a reasonable price.
2. Burney Acrylic Freestanding Tub With Insulation
When it comes to free-standing acrylic bathtubs with insulation, this freestanding tub is an excellent option. Given its capacity, this 2 person soaker tub looks stylish for contemporary and modern bathroom designs. That said, this bathtub does not have faucet holes which is not an inconvenience if you have a standing faucet.
With a lumbar angle of 111 degrees, this bathtub manages to keep things both comfortable and elegant. If you're looking to go all out for an additional 150 dollars, you can include air jets in your bathtub for a next-level experience. However, if you want a premium but reasonably priced bathtub, this option from Burney is a wise choice.
3. Asher Acrylic Rectangular Freestanding Tub With Insulation
With built-in adjusters, this acrylic free-standing bathtub makes for an excellent two-person soaker tub. While there are several options on the market that look elegant, this bathtub comes with a rectangular look that embraces modernism.
It is available in up to a 65-gallon capacity, and this high-end acrylic bathtub comes with foam insulation. Foam insulation helps ensure the water in your bathtub retains its heat for longer amounts ensuring you have a comfortable experience.
4. Sutor Acrylic Freestanding Tub
When it comes to bathtubs with contemporary design, this two-person tub from Suitor is an elegant choice. With all the options out there, this bathtub comes with curved edges and makes for an excellent bathroom showpiece.
With a durable acrylic build, this bathtub is both practical and aesthetically pleasing. The bathtub comes with a pop-up chrome drain and a flexible drain hose which makes the clean-up process easier. This CUPC-approved bathtub is available with up to a 69-gallon capacity.
5. Hartland Resin Freestanding Tub
Bathrooms that are sleek and stylish look effortlessly elegant, and this freestanding bathtub from Heartland definitely adds to that aesthetic. With a modern sculptural design, you can position this bathtub anywhere in the room that has the ability to accommodate a standing faucet.
It is made of resin, and the Hartland series features a mechanism that prevents overflow and also includes a neutral white drain that looks excellent with fixtures with a brass finish. This 2-person soaker tub can also include air jets with additional payment and has a capacity of 63 gallons.
6. 61" Tipton Acrylic Round Soaking Freestanding Tub with Integral Drain
Luxury bathtubs make your bathroom look outstanding and the Tipton acrylic bathtub is nothing if not luxurious. With an impressive capacity of up to 120 gallons, this circular two-person tub can be customized to have foam insulation to keep your bathwater warm for a longer period of time.
While the faucet holes and drain aren't included, you can customize the tub to include air jets. Besides this, you can custom paint this luxurious bathtub to the color you need. With the capability to handle integral waste and overflow, this bathtub is one of the best options for a luxury bathroom.
7. 72" Vista Copper Double-Slipper Roll-Top Tub with Pedestal
Creating a bathroom that looks elegant comes down to the minute details, and this Vista bathtub looks like something out of the Victorian era. With a water capacity of up to 70 gallons, this two-person bathtub definitely stands out from the crowd.
That said, this tub is not the most suitable for harsh materials like Epsom salts or even hard water as they can lead to residue collecting. The bathtub does not come with faucet holes however, do feature a horizontal band and rivets. So if you're looking for one of the best two-person soaker tubs created with 16-gauge copper, this option from Vista is an excellent option.
While it can seem daunting given the several expensive options, selecting a 2-person soaker tub need not be complicated. Like any other purchase decision, it all comes to the specifications of your bathtub and making sure your requirements are met. After making your decision based on the desired aesthetic for your bathroom and the budget you're working with, it is a smart move to add flair to your bathroom.
When it comes to setting up bathrooms and bathtubs a lot of the added costs are only seen during installation, so ensuring your budget takes into account the costs of installing your bathroom fixture can help you avoid any stress after your purchase.
Do you agree with this list? Let us know in the comments below.
Frequently Asked Questions
What is a 2-person soaker tub?
A two-person soaker tub is a bathtub capable of accommodating two people comfortably without any hassle. While not a requirement for the average household, two-soaker tubs are a luxury that adds sophistication and grandeur to any bathroom it's installed in.
How much do 2-person soaker bathtubs cost?
The better more premium two-soaker bathtubs start at $800. While this may seem steep, you have to take into consideration that the tub's capacity requires a durable build.
Do 2-person bathtubs come with a warranty?
Yes! A lot of premium two-person soaker tubs come with a warranty that lasts for a specified number of years. While there are several cheaper bathtubs available on the market, they don't guarantee a replacement for unforeseen and natural short-term wear and tear.


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NewJain University UG JET 2024 February 21, 2024
NewJEE (Main) 2024 Session 2 February 21, 2024
NewChrist University MBA 2024 February 21, 2024
NewCOMEDK 2024 February 21, 2024
NewPGCET 2023 - Final Round Schedule and Instruction February 21, 2024
NewUGCET 2024: Latest Update February 21, 2024
National Eligibility-cum-Entrance Test NEET (UG) 2024 schedule announced February 20, 2024
Know all the latest updates of MAT 2024 February 20, 2024
UGC's Revised Curriculum; Introduces Life Skills for Higher Education Institutions August 23, 2023
NTA Announces AIAPGET - 2023 Results: A Triumph for Aspiring AYUSH Scholars August 21, 2023
Last updated: 09 May 2022
Prime Minister Modi chaired a key review meeting on the implementation of New Education Policy NEP 2020. The meeting to review the implementation of NEP was held on 7th May 2022. PM Modi, Union Education Minister Dharmendra Pradhan, other senior ministers and the officials from Education Ministry, UGC and NCERT were present in the meeting. The Prime Minister had a discussion on the road map of implementation for National Education Policy; he also discussed the key aspects such as Hybrid Education System, implementation of National Curriculum Framework and UGC's two-degree plan.
Prime Minister Modi further quoted that in the last two years , several important steps have been taken to ensure the implementation of key initiatives under NEP 2022. The Prime Minister also said that the key goal of NEP 2022 is to bring about equity, inclusivity and quality in the education sector. The Prime Minister further directed officials and ministers to prepare a detailed plan for the implementation of other key projects and initiatives to achieve the target.
School Level Initiatives
According to the details, the National Steering Committee headed by Ex-ISRO chairman Dr.K Kasturirangan has been given the responsibility of developing the National Curriculum Framework, NCF. The Prime Minister further added that the primary target to help the school students by providing them a quality education and he also reviewed implementation of key initiatives at School Education Level including ECCE in Balavatika, Nipun Bharat, Vidya Pravesh, examination reforms and innovative methods like Art-Integrated Education and Toy-based method.
The Prime Minister further informed that it helped to bring out the best learning outcomes and increased the holistic development of children. During the meeting, the Prime Minister proposed the development of a Hybrid Learning Method for school children to avoid over exposure of technology to school-going children. The Prime Minister also advised to organize regular health check-ups of school students by using the technology-aided solution. The Prime Minister further added that secondary schools with science labs must engage with farmers to help them create awareness about the quality and health of soil.
Higher Level Initiative
The Prime Minister further discussed the implementation of the Two Degree Programme for higher education by UGC with multiple entry and exit options for college students. The Prime Minister further stated that the implementation of the academic bank of credit and also reviewed the finalisation of the development of (NHEQF) National Higher Education Qualification Framework on which the work is still going on. There is a plan to revise the curriculum framework and credit system for UG Programme based on NHEQF.
Framework Of Multi Modal Education
The Prime Minister further added that online and MultiModal learning have been promoted in schools and higher education institutions in the recent past. The multi modal education platforms and initiatives launched under the same have played a vital role in bringing down the learning loss for students during COVID 19 pandemic. Not only this, but the initiatives also made it possible for education to reach remote areas which were not accessible in the country.
There has been a constant increase in registrations of key platforms which offer MultiModal Education including "DIKSHA", "SWAYAM" and "SWAYAM PRABHA", besides virtual lapse and other online resources in the last two years. The availability of course related resources and study materials in multiple Indian languages had been very well appreciated by the students and the learners. The Prime Minister further stated that besides, the sign language and audio formats have aided visually impaired students and has been effective for specially challenged children.
Students can get more educational news and updates by contacting us on +91 9916505050/+91 8088602346. They can also email us at firstname.lastname@example.com or can also reach us at email@example.com for more details.
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subset: commoncrawl


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(Newsmax/"Wake Up America")
By Sandy Fitzgerald | Friday, 10 September 2021 08:31 AM EDT
President Joe Biden's wide-reaching vaccine mandates were announced to "cover up the insanity and the debacle of Afghanistan," and come as another of the self-inflicted crises the president has created in his first eight months in office, Rep. Greg Murphy told Newsmax while discussing his recent column about the president's failures in what should be his "honeymoon" period.
"Normally there's a honeymoon period where the elected president would enjoy good ratings as they move through at least their first year," the North Carolina Republican said on Friday's "Wake Up America." "But now, because of the self-inflicted crises that Biden has brought upon this nation, his approval rating is plummeting."
In his column for the Washington Examiner, Murphy outlined the president's "top-five blunders" as the pullout from Afghanistan, his "broken promises," being pulled by the left on agenda items such as defunding the police, the border crisis, and the "tax-and-spend agenda" that has led to higher inflation.
"Look at our economic situation, the inflation that is going on [with] paying people to stay at home," Murphy said. "This inflation is here to stay, and it's going to disproportionately affect the poor."
Further, he pointed out that close to 2 million people have come across the U.S.-Mexico border, and they are not facing vaccination requirements.
"This is just one debacle after another," Murphy said. "I think Middle America, which in my opinion is the people who actually make how we do national or state elections, have woken up. They didn't like Trump's personality, but now they can't stand Biden's policies."
It's also a "troubling time" for the nation because even if Biden wouldn't finish his term, it is a "constitutional crisis" about "who steps forward," Murphy said.
"You know how many times that Biden said recently, 'I'm not supposed to do this,'" said Murphy. "Somebody is pulling him. He's being definitely a puppet. So does he have the mental capacity to lead the greatest country in the free world? I really have my doubts about that, and I think most Americans do, too. It is a scary time for us."
He also called it "hypocrisy" that Biden isn't calling for vaccination mandates for the immigrants crossing the southern border or the refugees coming into the country from Afghanistan and the Middle East.
"This is what we're seeing from the Democratic Party," Murphy said. "It's hypocrisy. It's do as I say, not as I do. ... Those folks should be ... vaccinated also if they're going to do a mandate."
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Dear Mama,
I know you're thinking that sweet girl in braids can't possibly be old enough to have left for college or you're in disbelief that the little guy with a lisp who loved racing RC cars has moved away for freshman year. But yes, it's true, and it tugs so heavily at your heart.
You don't feel ready for them to start "adulting," but hasn't that been the goal all along? You hoped to raise a productive, functional human being who fends well for him or herself and serves others with compassion. You've done your job, now let them try it out on their own. You might not feel they are ready for this but, truly, they are.
I promise you, it gets better.
Oh, I know it isn't easy. There's an empty spot at the table and an even emptier spot in your heart. You miss them with that always present, fiercely protective mama's love. Things aren't the same in so many ways and, although you hope they're doing just fine, there's always a bit of a niggling doubt. "Is he making friends?" "Did she meet that deadline?"
You find yourself in their bedroom, looking over the childhood things left behind. You conjure up bittersweet memories of days gone by. How did time move so quickly? You are so incredibly proud of your child that your heart could burst, but you also miss them so much that you find tears in your eyes more often than you care to admit.
I promise you, it gets better.
You trust and you worry. You worry and you hope. Will they really be OK? I promise you, it gets better.
You search for the delicate balance between guidance and help versus interference and nagging. You bite your tongue more times than you can count because you know they've got this now.
New adventures await your child.
Phone calls and FaceTimes are frequent at first then space out a bit as the weeks go by. You hear about a project or paper due soon and new friends they're going to coffee with, but it feels so different because you haven't met those friends and weren't asked to proofread the paper before it was turned in. You feel as if you're missing out on big, important pieces of their life. Maybe you are, but that's the way it's supposed to be. They're living their life and finding their way.
I promise you, it gets better.
But then, you visit for a weekend or they come home for a break. You see a change. It's something remarkable. You witness the confidence and maturity you hoped was in them all along but hadn't fully seen in action. You hear about incredible conversations with professors, opportunities and activities they have been bold enough to pursue and mini adventures taken with newfound friends.
It feels a bit better.
You get a call asking for advice. It could be about anything, but that phone call changes your perspective. You know your child trusts your opinion. You're reminded that your child values what you have to say. You are so glad you stepped back and let them take the lead. They're owning it. They're doing it. They're accomplishing big things in a brave way.
Summer break arrives and your child moves home. You love that they're here. Maybe it's not smooth sailing. Maybe old habits try to settle back in. It's a learning curve to invite an adult child back into the family home, a living situation that both parties need to adjust to, requiring a huge level of respect on both sides. Maybe it's smoother than you could have expected and all of you are simply thankful to be a part of each other's daily lives again, if even for a while.
It feels a bit better.
You hear long term plans—adding a minor because of a communications course they loved, a semester abroad or a potential business plan after graduation. So many things.
Sophomore year arrives. You anticipate the emotions. Packed up and gone. New adventures await your child. For you, it's still bittersweet. Perhaps there's lingering sadness but, this time, it's mostly for you, not out of worry for them. They have shown their abilities and you have no doubt they will continue thriving. You simply look forward to your next visit to campus or their next weekend home. Your child is doing it, making good decisions and finding their own path and you couldn't be prouder.
Relax, mama, it's better.


text:
Future Spending Priorities
- Repairs - e.g. general repairs to your home, tackling damp and mould
- Resident and building safety - e.g fire and gas safety, building safety regulations
- Capital works - e.g. replacing kitchens and front doors, improving estates, making your homes more energy efficient, maintaining lifts
- Tenancy Services - e.g. rent collections; management of council homes, and tackling anti-social behaviour
- Service Improvement / Complaints - e.g. customer services, managing and monitoring service performance, supporting service improvements and driving up standards.
- 1st Prize - £100 voucher
- 2nd Prize - £50 voucher
- 3rd Prize - £25 voucher
For more information visit www.hackney.gov.uk/housing-priorities-survey
How to use the Simulator
Using our interactive online tool is simple. You can allocate a total of 100 points across services provided in each of these areas by using the sliders to highlight what are the most important services to you (0 being low priority and 10 being high priority). You will also be able to see what your decisions could mean for their future delivery by clicking "i" to see potential impacts.
You must allocate all 100 points before you can submit your response. If you go over the 100 points, then you must adjust your responses. When the box in the top left changes from red to green, you have completed the task.
You will also be able to give us your comments and ideas. This will help us understand what is important to you when we make our budget proposals later this year.


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The neural mechanisms for time measurement are currently a subject of much debate. This article argues that our brains can measure time using the same dorsolateral prefrontal cells that are known to be involved in working memory. Evidence for this is: (1) the dorsolateral prefrontal cortex is integral to both cognitive timing and working memory; (2) both behavioural processes are modulated by dopamine and disrupted by manipulation of dopaminergic projections to the dorsolateral prefrontal cortex; (3) the neurons in question ramp their activity in a temporally predictable way during both types of processing; and (4) this ramping activity is modulated by dopamine. The dual involvement of these prefrontal neurons in working memory and cognitive timing supports a view of the prefrontal cortex as a multipurpose processor recruited by a wide variety of tasks. © 2006 Elsevier Ltd. All rights reserved.
Original language | English |
Pages (from-to) | 401-406 |
Number of pages | 5 |
Journal | Trends in Cognitive Sciences |
Volume | 10 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 2006 |
- physiology: Attention
- physiology: Awareness
- physiology: Brain
- Brain Mapping
- physiology: Cognition
- physiology: Dopamine
- Humans
- physiology: Memory, Short-Term
- physiology: Mental Recall
- physiology: Neural Pathways
- physiology: Neurons
- physiology: Prefrontal Cortex
- physiology: Time Perception


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SFist spent last weekend luxuriating in the unseasonably warm weather in Sonoma doing what one does in Sonoma-- drink lots of wine and eat super-yummy food. The occasion? Sonoma's VinOlivo Festival.
Last Saturday, the vintner's of Sonoma along with their restaurants put together a festival honoring the good life, Sonoma-style. For a mere $75, you could wander around sampling all the finest Sonoma has to offer. And Sonoma has a lot to offer.
More pictures of the festival and Sonoma after the jump


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In 1744, the Star and Garter club drafted the first Laws of Cricket, whose members subsequently established the famous Marylebone Cricket Club in https://parimatch.in/en/page/cricket-bbl-srl. The club immediately became the "keeper of the laws" and still retains this role. According to the rules of the game, a cricket team led by a captain consists of 11 players.
One of them plays the role of a bowler. Its main function is to throw the ball so that the batsman (batsman) cannot hit it. If the batsman hits the ball, he receives points for his team. Wicket keepers – cricket goalkeepers – also take part in the game. Their main goal is to protect the gate (gate) of their team.
At the moment when the batsman hits the ball, the position of the players on the field changes. One team runs after the ball to touch one of the wickets. Two players from the other team earn points by moving from one wicket to the other on a clay path.
During the game, there are two teams in the field. However, in the team that hits the ball, there are only two players on the field, and in the serving team – all 11. Two referees work at the matches, who monitor the observance of the rules, make all the necessary decisions and report them to the markers – the people who keep the score.
The main equipment of the players is a leather ball and a wooden bat shaped like a spade. A cricket field is called a pitch. It is a rectangular area 20 meters long and 3 meters wide. There are also gates on the field – three posts 71 centimeters high. They act as a gate.
The Development of Modern Cricket (BIG BASH LEAGUE, SRL)
Currently, there is an International Cricket Council, which includes more than a hundred countries of the world. For most countries of the former British Empire, cricket remains the main sport, particularly in the Indian subcontinent.
Cricket is still evolving. This is how new forms of the game appear, such as Cricket Twenty20. Twenty20 is an international cricket tournament in which all members of the ICC participate. This is a global tournament in which all countries playing cricket participate. The final winner receives Twenty20 World Champion status.
The duration of a match of this format is determined not by a time limit, but by a set number of innings. The T20 is credited with reviving cricket in the 21st century. Since its inception, players have quickly adapted to the demands of the game by working on their fitness, serving and shooting. The game has also evolved technically. There was a special ball tracking program, infrared cameras and technology for monitoring the edges of the field in order to better see the batted ball.
Simulated Reality League – Big Bash League SRL has been around for quite some time now. This is just a great option for fans of such sports as cricket. Now you can bet in a slightly different way. Big Bash SRL T20 is a new type of betting. You already know about the Twenty20 league. Well, the Big Bash SRL T20 is the latest and greatest variant of the Twenty20. On the Parimatch website, you can track the digital championship and make bets in live and prematch modes.
This competition is based on a real league. But it is done with the help of computer graphics. That is, it is a virtual cricket. Betting on a virtual game is no different from betting on regular cricket. Bets are similar to bets on all team sports. This betting option was popular when the coronavirus pandemic began. In addition, you can bet on this event when there are no real games.


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The Joniu Shrine is a perfect spot to get an easy Light of Blessing before visiting Zora's Domain in Tears of the Kingdom.
You won't need to struggle with a complex puzzle to solve this one, as it is one of the few Shrines that don't require a puzzle to reach the altar.
However, the tricky part with the Joniu Shrine is finding it, as it is underground. What's more, activating this Shrine also requires you to complete a minor Shrine Quest.
Where to Find the Joniu Shrine in TOTK
You can find the Joniu Shrine underground, inside the Ralis Channel. In detail, this subterranean water channel is accessible from the Ralis Pond, south of the Upland Zorana Skyview Tower.
The Shrine is only accessible after solving "The Ralis Channel Crystal" Shrine Quest, which you can start and complete in the same location.
- If you have already unlocked the Upland Zorana Skyview Tower, fast travel to this location. Otherwise, you can travel as close as possible to Zora's Domain in the northeastern part of Hyrule.
- Once at the Skytower or near this region, travel to the Ralis Pond. This pond is a small shallow body of water directly south of the Skytower.
- As soon as you reach the pond, you will see a small cave entrance leading to the Ralis Channel. Enter this location.
- Inside Ralis Channel, you will find a green glowing crystal. Interact with the crystal by approaching it and selecting "Examine." This will trigger "The Ralis Channel Crystal" Shrine Quest.
- To solve this quest, you must take the crystal to the other side of the water channel, where the green beam is pointing. To achieve this, you'll have to build a raft with the wood planks and Zonai Devices scattered around.
- This raft can be as complex or as simple as you want. You can go with whatever build you prefer as long as it takes you upstream to the location where the green beam is pointing. We are adding an image of the very simple raft build we used in the image below.
- Pro-tip: You can attach the green crystal to the raft. This will prevent the crystal from rolling around and falling into the water.
- Lastly, to unlock the Shrine, use Ultrahand to get the green crystal to the location the beam indicates. Once the crystal is there, it will become the Joniu Shrine, and you will be able to activate it in TOTK.
- Finally, you only need to enter the Joniu Shrine in TOTK and get the rewards. There is no puzzle here. Instead, you are greeted with an area called Rauru's Blessing. In this location, there's just a staircase that leads to the following rewards:
- A chest containing a Large Zonai Charge
- The altar with a Light of Blessing


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Bank of America, N.A. v. Peppertree Homeowners Association et al
Filing 21
ORDER granting 20 Stipulation; The deadline for initial expert witness disclosure shall be extended by three weeks to November 28, 2017, and that the deadline for rebuttal expert disclosures shall be extended to December 29, 2017. Signed by Magistrate Judge George Foley, Jr on 11/20/2017. (Copies have been distributed pursuant to the NEF - JM)
Disclaimer: Justia Dockets & Filings provides public litigation records from the federal appellate and district courts. These filings and docket sheets should not be considered findings of fact or liability, nor do they necessarily reflect the view of Justia.


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The planet is heating up. The Arctic is melting. July is on course to be the hottest month ever measured on Earth, according to climate scientists. Extreme weather is becoming the norm. Climate change looks like an insoluble problem right now, but investors should be asking themselves this question: how can I make money from it?
This is not as cynical as it sounds. If we are going to slow or reverse climate change, businesses have to help and savers can do their bit by investing in the new green economy. Renewable energy, battery-charging technology, carbon capture, electric vehicles and even plant-based burger patties can help make the world well again, and with luck might make investors richer too.
Despite growing concern over climate change and other problems such as plastic pollution, ethical investing still hasn't hit the mainstream. For example, in the UK, ethical funds make up less than 2 per cent of total investments. But Kay Van-Petersen, global macro strategist at Denmark's Saxo Bank, says attitudes are changing and sustainable investing is now one of the hottest long-term investment trends, particularly among younger investors, so-called Millennials and Generation Z.
Ms Van Petersen says there is a growing body of research showing that investing does not have to be a trade-off between doing something good and sacrificing returns. To take one example, last year UK investment platform Hargreaves Lansdown found that the 11 ethical funds with a 10-year track record delivered a total return of 125.2 per cent, only slightly lagging the average 134.4 per cent return from UK All Companies funds.
Comparisons are tricky and performance can be cyclical. Ethical funds tend to focus on small and medium-sized companies, which find it easier to be cleaner and greener than sprawling multinationals, but will underperform when the big-caps swing into favour. This typically happens during recessions, as large diversified global businesses are better able to withstand an economic downturn than smaller companies. Smaller companies can also struggle when energy prices are rising, whereas oil and gas companies do well.
What is 'ethical investing'?
Another challenge facing investors is that there is no single agreed definition of what constitutes an ethical investment. Some fund managers take a positive approach and actively target, say, renewable energy stocks, while others invest more generally but screen out environmental offenders such as oil and mining companies.
Investing with a clean conscience is not new as such, and has a proud history. The first ethical investment fund, the US-based Pax World Fund, started almost 50 years ago in 1971, while the UK followed in 1984 with the Friends Provident Stewardship Fund.
Ethically concerned Sharia-compliant investment funds also have a long history, first appearing in Malaysia in the 1960s. The sector is growing as it targets Muslims who want to invest in line with their religious beliefs. Today the sector goes by many different names, including ethical investing, sustainable investing, socially responsible investing (SRI) and more recently, ethical and social governance (ESG) investing.


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How do I Am Useless And Gay Shirt one sneak backstage to their own show?? They call him an old mate. I lold for real. I'd managed to sneak into the shakey knees festival in the US where I met some Australian friends and we went to see Tame Impala. So he said he was family. Then became family. Wack. Imagine being that big of a fan of Peking Duk. All the Basic Bros are into them for some reason. Guess that makes me a basic bro then, gutted. Yeah, hectic aye lad? Living your best life. Yeah mate, if you mean being able to enjoy whatever music without worrying about what random blokes on the Internet think of me.
I Am Useless And Gay Shirt, Tank Top, V-neck, Sweatshirt, And Hoodie
And then I Am Useless And Gay Shirt loads of people started buying us drinks to congratulate us on the set. I got chucked out at this point cause someone thought I was under 21 (I wasn't) but I met my friends in New Orleans a few days later but apparently, the real band came in a few minutes after I left and thought it was funny that my mates had sunk in so they chat drank and chatted all night. Such a smart move. I understand you're the machine? I swear I saw this already. Damn definitely swell. TIL there's an Australian band named Peking Duk!!
Other products: Official Jesus Was An Unarmed Black Man Shirt


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Find Top Travel Accessories for Your Nissan in Devon
Your Nissan experience isn't complete without all your gear and equipment! Shop outdoor equipment accessories [2] that outfit your Nissan to suit your lifestyle. Shop roof racks for your surfboard, kayak, bike, or even skis, and easily haul your equipment for all your adventures in and around Devon. Are you hoping to take a camping trip in your Nissan? Get a durable hatch tent that attaches to your vehicle. This one-of-a-kind accessory gives you a place to sleep without having to find a campsite that's far away from your Nissan. Do you need to maximize trunk space on your camping trip? Try a rooftop luggage carrier [3] made with your vehicle's specifications in mind.
Do you want added remote functions with your Nissan? The virtual key [4] lets you manage access to your Nissan with a simple smartphone app. Unlock or lock doors, start your vehicle, [5] or give others the ability to start your vehicle with just a tap. Choose the right virtual key kit for your model and year. Then, head to your nearest Devon Nissan dealer for installation services and help with configuration.
Upgrade Your Nissan Inside and Out
Nissan Parts & Accessories offers a selection of all the interior and exterior accessories imaginable that allow you to upgrade your way to your dream car — from new step rails to lighting that adds an air of sophistication. Keep the outside of your Nissan in tip-top shape with bumper, door edge, and hood protectors, and make your interior easy to clean with durable all-season floor mats and cargo protection mats designed to fit your Nissan seamlessly. Because Nissan exterior and interior accessories are made for each model, you don't have the worry of wondering if they'll fit. Enjoy the quality you deserve when you get genuine Nissan accessories in Devon, PA. Go straight to the source and rely on the people who know your Nissan inside and out!
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Your Nissan Frontier® or TITAN® is built to haul, tow, and help you through the toughest jobs. When you want more from your truck, turn to Nissan Parts & Accessories. Order towing and hauling accessories [6] like a drop-in bed liner to help protect from scuffs and scratches, a truck bed extender to support larger items, and weight-distributing hitches to help make towing easier.[7] When you need your truck bed to double as a workspace, a toolbox or TITAN Box can help keep everything protected and tidy, with plenty of space left for hauling.[7]
No matter what you want from your Nissan car or truck, Nissan Parts & Accessories can help! Buy online today and have your new accessories delivered right to your Devon home. For help installing your genuine Nissan accessories rely on your neighborhood Nissan dealer in Devon, PA.


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Mill Pond Canada Geese – 18-1/2 x 24-3/4; Premiere Edition; Edition Size 250; 7 x 9 Lithograph; $795.00 U.S.
Mill Pond Canada Geese also comes as a Premier Edition with only 250 signed and numbered. It is a 2 Piece Set including the large print
above , signed out of only 250 and this Original Lithograph pictured below, which is also signed and numbered out of 950.
"This old mill has been one of my favorite places since my younger days. For that reason, I felt that it would be a fitting subject for the 25th Anniversary
of Mill Pond Press, where I have had such a long and pleasurable relationship, just as I have had with this mill." – Robert Bateman
Robert Bateman has been called the most famous living artist. He continues to paint and tour the world to promote conservation and preservation of nature. We have represented Robert Bateman for decades and are now the sole publisher and distributor of his reproductions. We are so honored to work with him and witness his success. He has made such a massive contribution to the art world and the natural world as an artist and educator of the earth's most important resources.
Nature as a subject is becoming more and more popular as our environment is in peril. What better subject is there than the beautiful creatures we share this world with? Robert Bateman's appreciation and understanding of nature are apparent in his paintings. He is able to paint flora and fauna the way your eye would perceive it in real life. It is important that the animal takes full attention. The background becomes muted, and therefore it doesn't take too much focus away from the subject. His paintings seem effortless and masterful all at once.
Bateman's eye for composition is unparalleled. Each painting is a composed like a symphony, leading the eye to wander. From the backyards of North America to the sprawling plains of Africa. Robert Bateman captures nature the way it should be enjoyed. Above all he is a champion of wildlife. For this reason he has become a household name for art collectors.


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Centerburg Solar Power Information & Peak Sun Hours
Solar Green Energy Summary for Centerburg, Ohio
Lattitude: 40.3035
Fixed Tilt Sunlight Hours: 4.3 hours per day
1-Axis Tilt Sunlight Hours: 5.2 hours per day
2-Axis Tilt Sunlight Hours: 5.6 hours per day
Peak sun hours is arguably the most important number to consider before installing your solar panels. Unlike total sun hours, peak sun hours are calculated by looking at the amount of sunlight hours in a 24 hour period that is strong enough to be absorb by a solar panel. One way to imagine peak sun hours is to think about a solar powered calculator you owned in school. If you covered the solar panel with your finger, or tried to use the calculator in the dark, the calculator would not work. As you slowly exposed the calculator to light the calculator would eventually turn on and be usable. The same is true with peak sun hours; these are the hours that your solar panels receive enough sunlight to work. Looking at the average peak sunlight hours of 4.3 per day can help you determine the amount of solar panels you need to install to power your home or business in Centerburg, Ohio.
The latitude at the equator of the earth is zero degrees. This is where sunlight strikes the earth most directly. Due to the earth's curved shape, sunlight hits at a various angles depending on location. As latitude increases, the further you are located from the equator and more variance you see in sunlight hours. The latitude of Centerburg is 40.3.
They type of solar panel you use has an affect on the average peak sunlight hours. Some panels allow for movement, so they can track the sun as it rises in the east and sets in the west, or as the seasons change and the sun's path changes. A fixed panel remains fixed and does not have the ability to rotate, whereas a 1-axis and 2-axis panel can adjust with the sun.
Another reason to consider average peak sun hours is because weather can dramatically affect the day-to-day output of solar panels. It goes without saying that a dark stormy day will produce less output than a clear sunny day. Looking at a yearly average helps account for these daily variables.
In Centerburg you can look at the average peak sun hours of a fixed solar panel mount, which will be 4.3 hours. This number iis an estimate based on data of previous years. With a tracking mount in Centerburg you could theoretically increase the amount of peak sun hours per with a 1-axis mount, and get 5.2 hours, or a 2-axis mount and potentially increase your average to 5.6 hours.


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Thursday 7 October 2010
Wee Memories
Very quick post as I am rushing out to a meeting at school. This is my entry for the challenge over at sweet Jenny's blog this week, titled "Tutti Frutti!!" As the title suggests the challenge is to include fruit on your card, so I have used the cute apple stamp from Hero Arts. Two of the apples are coloured with copics and two coloured and coated in Glossy Accents.
Sorry for the rush.
14 comments:
- Alice said...
love those cute apple! wonderful card, Sally!
- 8 October 2010 at 00:33
- Barb said...
Love this, Sally! Your coloring is wonderful and the glossy apples look fab!
- 8 October 2010 at 01:34
This is gorgeous Sally! Love those apples! Thanks for playing along with us at Wee Memories :)
- 8 October 2010 at 03:46
- Dawn T said...
very yummy looking Sally.. your apples looks so pretty
- 8 October 2010 at 05:07
- Arlene said...
Love this fresh and original card. Those apples look yummy to me.
- 8 October 2010 at 05:52
- Dotty Jo said...
What a sweet idea for a card Sally! Love the apples and that cute button with the twine! Jo x
- 8 October 2010 at 07:50
- Vanessa said...
Oh, yummy yummy! Love this sweet card!
- 8 October 2010 at 09:27
This is SOOOOO cute!
- 8 October 2010 at 16:42
- Vicky said...
Love the recipe idea Sally and the glossy apples - so sweet. :)x
- 8 October 2010 at 19:27
- Suzanne C said...
Sweet recipe card! Looks delicious!
- 9 October 2010 at 03:32
- Laurel said...
Oh I love it! Thanks so much for playing at Wee Memories.
- 9 October 2010 at 04:18
- Ann said...
Mmm, yum! Thanks for playing with us Wee Memories girls!
- 9 October 2010 at 04:18
- Nancy said...
Love the red apples on the blue background...looks so pretty! And the recipe card in your handwriting is such a charming touch...wonderful card, Sally.
blessings! - 10 October 2010 at 05:27
- stampingandstitching said...
Wonderful recipe card, Sally and those apples look so yummy!
- 11 October 2010 at 00:19


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Heres what i do when i need to download a specific directory. I know i need to be using p and o to do this but it does not seem to be working for me. This guide is useful, if, for example, you are using wget in a script, and want to automate downloads which should be stored in different directories. If i wanted to download content from a website and have the tree structure of the website searched recursively for that content, id use wget. If youve ever wanted to download files from many different items in an automated way, here is one method to do it. How to download files to specific directory using wget. For example, in its most basic form, you would write a command something like this.
We refer to this as to recursive retrieval, or recursion. How to rename file while downloading with wget in linux. First released back in 1996, this application is still one of the best download managers on the planet. Oct 26, 2010 how do i use wget command to recursively download whole ftp directories stored at hometom from ftp. Aug 25, 2018 wget download files to specific directory if you are downloading a heavy file, you may want to add the c or continue flag, which means continue getting a partiallydownloaded file. If a file is downloaded more than once in the same directory, wgets behavior. Cant seem to find the right combo of wget flags to get this done. If your av is giving you trouble, and you dont need the documentation or debug symbols, you can download wget. Newer isnt always better, and the wget command is proof. Wget is a free utility available for mac, windows and linux included that can help you accomplish all this and more. How to download files to specific directory using wget tecmint. I need to use wget to download a file to the directory varcachefoobar so, as an example. I have a web directory where i store some config files.
If the server supports regetting, it will instruct the server to continue the download from where it left off. The directory prefix is the directory where all other files and subdirectories will be saved to, i. Esgf wget scripts are smart enough to recognize if files have already been downloaded and skip them. Note that only at the end of the download can wget know which links have been downloaded. Use the tree command to show a directory and all subdirectories and files indented as a. Download using wget to a different directory than current. How to use curl to download files from the linux command line. If i wanted to interact with a remote server or api, and possibly download some files or web pages, id use curl.
I have a solaris 9 system and was trying to familiarize myself with how the filesystem is laid out. I have tried several methods using wget, and when i check the completion, all i can see. How to use the wget linux command to download web pages and files download directly from the linux command line. Apr 17, 2020 the wget utility also retries a download when the connection drops and resumes from where it left off, if possible, when the connection returns. Im writing this into a php script and running on unix. Im trying to recursively download a directory tree, which is the root of a javadoc tree. Because of that, the work done by k will be performed at the end of all the downloads. Awgg is a lightweight multiplatform and multilanguage download manager, basically a wget frontend and other tools like aria2, curl, youtubedl and axel. I was wondering what the following directories were for legacy, some administrative reason, etc the reason i ask about these specific directories is that they have executables with the. The fact that the former links are converted to relative links ensures that you can move the downloaded hierarchy to another directory.
Using wget to download files from ftp server, recursive mode. What would be the fastest way to recursively retrieve entire directory listing from an ftp server using wget curlwhatever. The ls command lists the content of the current directory or one that is specified. Can you tell me how to download the directory tree just starting from project1 in this url. In this article, we will show how to download files to a specific directory without. What would be the fastest way to recursively retrieve entire directory listing from an ftp server using wgetcurlwhatever. I dont need to download any files, just directory and file names. If the o flag is excluded, the specified url will be downloaded to the present working directory. The same happens when the file is smaller on the server than locally presumably because it was changed on the server since your last download attemptbecause.
With it, you dont have to start the download afresh. Jun 04, 2018 the directory prefix is the directory where all other files and subdirectories will be saved to, i. Here is a generic example of how to use wget to download a file. To get all the files to download to a single folder, use the following. The program was designed especially for poor connections, making it especially robust in otherwise flaky conditions. Id like to use wget to pull those files down and maintain their current structure. Whether you want to download a single file, an entire folder, or even mirror an entire website, wget. What makes it different from most download managers is that wget can follow the html links on a web page and recursively download the files. I have been trying to get wget to download all files to a specific directory. Downloading files using wget bioinformatics workbook.
How do i use wget command to recursively download whole ftp directories stored at hometom from ftp. Download entire folder using wget command in linux txt. Whether you want to download a single file, an entire folder, or even mirror an entire website, wget lets you do it with just a few keystrokes. How to install and use wget on mac make tech easier.
Linux wget command help and examples computer hope. That will save the file specified in the url to the location specified on your machine. Using wget to recursively fetch a directory with arbitrary files in it. The syntax for downloading to a specific directory. You can add more cutdirs with higher numbers if you are dealing with sites with a deep structure. If the download was interrupted before having finished, simply run the script in the same directory again. Im trying to download multiple files and need to rename as i download, how can i do that and specify the directory i want them to download to. Downloads an entire directory tree from an ftp server to the local destination.
To download an entire directory tree with wget, you need to use the rrecursive and npnoparent flags, like so. In certain situations this will lead to wget not grabbing anything at all, if for example the robots. Im using windows xp, and using wget for windows the version of wget is 1. By default, wget downloads files in the current working directory where it is run. O is the option to specify the path of the file you want to download to. Awgg is written in free pascal, using codetyphon and lazarus ide. Use man ncftpget and man wget for more options, and if you have other ways, please share them with us. How to use wget, the ultimate command line downloading tool.
The ultimate wget download guide with 15 awesome examples. Apr 26, 2012 if youve ever wanted to download files from many different items in an automated way, here is one method to do it. Mar 25, 2011 using wget to download files from ftp server, recursive mode. Craft a wget command to download files from those identifiers 4. The wget command can be used to download files using the linux and windows command lines. By joining our community you will have the ability to post topics, receive our newsletter, use the advanced search, subscribe to threads and access many other special features. Downloading in bulk using wget internet archive blogs.
All the wget commands you should know digital inspiration. Recursively download files and folders from ftp ncftpget. Jun 10, 2009 everybody knows wget and how to use it, its one of my favorite tools expecially when i need to download an iso or a single file, using wget with recurse on an entire site is not a big problem but when you need to download only a specified directory it could cause headaches when dealing with different options. I need to download all of the contents within each folder and subfolder. By default, wget strictly follows a websites robots. Download all folders, subfolders, and files using wget super. This will tell wget to not go up the directory tree, only downwards. We refer to this as to recursive retrieving, or recursion.
The p option downloaded all the files to the specific directory however it created 2 new directories inside the target directory. To download a directory recursively, which rejects index. Recursively download files and folders from ftp ncftpget wget. Using wget to recursively download whole ftp directories server. Nov 26, 2016 newer isnt always better, and the wget command is proof. The wget command is an internet file downloader that can download anything from files and web pages all the way through to entire websites. Dec 17, 2019 the wget command is an internet file downloader that can download anything from files and web pages all the way through to entire websites. Recursive retrieving can find a number of applications, the most important of which is mirroring. Wget has been designed for robustness over slow or unstable network connections. By default, wget will create a local directory tree, corresponding to the one found on the remote server. The wget utility also retries a download when the connection drops and resumes from where it left off, if possible, when the connection returns. It is also useful for www presentations, and any other opportunities where slow network connections should be bypassed by storing the files. When no download all button is available or when you dont have spare time to read it immediately you wish to grab all the directory content and. Even the download of a partially downloaded file will be continued.
Because it is noninteractive, wget can work in the background or before the user even logs in. Use the tree command to show a directory and all subdirectories and files indented as a tree structure. Apr 10, 2019 wget is a noninteractive commandline utility for download resources from a specified url. Download files and create same file structure as the source unix. Download a file from the web directly to the computer with wget.
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The MarketWatch News Department was not involved in the creation of this content.
Jan 11, 2021 (The Expresswire) —
The globalconnected agriculturemarket size is projected to reach USD 7.22 billion by the end of 2026. The demand for smart water management will aid the growth of the market in the coming years. According to a report published by Fortune Business Insights, titled "Connected Agriculture Market Size, Share and Industry Analysis, By Component (Solutions, Services), By Application (Pre-Production Management, In-Production Management, Post-Production Management) and Regional Forecast, 2019-2026," the market was worth USD 1.84 billion in 2018 and will exhibit a CAGR of 19.1% during the forecast period, 2019-2026.
To Gain More Insights into the Connected Agriculture Market, Browse Summary of the Research Report:https://www.fortunebusinessinsights.com/connected-agriculture-market-102061
The increasing demand for inventory and labor management in agricultural activities will create a wide adoption of connected agriculture across the world. Recent technological advancements in these systems have yielded products of high calibre. A few of the latest connected agriculture systems cater to the environmental-preservation needs. The increasing awareness regarding water consumption and shortages and contributions from government as well as private organizations will have a direct impact on the market in the coming years. Use of automated concepts such as artificial intelligence and machine learning have allowed improved efficacies. The rising demand for maximum product efficacies with minimum energy consumption will emerge in favor of the companies operating in this market.
Report Overview:
The report provides a thorough analysis of the global connected agriculture market across five major regions, including North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa. It analyzes the ongoing trends in each of these regions and highlights the products that have witnessed the highest demand. Besides this, it highlights the factors that have had the highest impact on the market in recent years. The competitive landscape has been discussed in detail and predictions have been made with respect to leading companies and the strategies adopted by these companies. Moreover, the report includes market figures for a forecasted period of 2019-2026.
List of Companies Profiled:
- IBM Corporation
- Microsoft
- Cisco Systems Inc.
- Iteris Inc.
- Trimble Inc.
- Ag Leader Technology
- Decisive Farming
- SWIIM System, Ltd.
- Orange Business Services
Request a Sample Copy for more detailed Connected Agriculture Market Overview:https://www.fortunebusinessinsights.com/enquiry/request-sample-pdf/connected-agriculture-market-102061
Major Drivers:
- Increasing Demand for Smart Water Management:With regard to the ongoing issues surrounding global warming and excessive use of energy resources across the world, water saving is the focus of attention among major businesses and activists around the world. Water shortages across the world have brought about the need for sustainable devices and products favouring less consumption and maximum output. The use of connected agriculture caters to the aforementioned factors.
- Increasing Penetration of Smartphone and Internet:As connected agriculture includes the use of smartphone and applications, the increasing usage of internet creates a huge platform for market growth. In a bid to establishing a stronghold in the market, several companies are promoting the use of connected agriculture equipment by developing mobile phone applications. This will not only help the company generate substantial market revenue, but will encourage the use of connected agriculture devices across the world.
Regional Analysis:
High Investment in Product RandD to Aid Growth of the Market in North America
The market in North America is projected to account for a comparatively higher share over other regions. The emphasis on development of advanced farming technologies by major companies has been key to the growth of the market in this region. Moreover, the growing investment in the development of these products, and encouragement by government as well as private organization will aid the growth of the market in this region. "Driven by increasing use of AI and predictive analysis, connected agriculture is gaining rapid popularity across the United States," said a lead analyst at Fortune Business Insights. As of 2018, the regional market was valued upward of USD 626.7 million.
Noteworthy Industry Developments:
- December 2018:Tech-giant IBM announced a collaboration with agro-based 'HelloTractor'. Through this collaboration, IBM plans to introduce an advanced agricultural analytics as well as decision-making platform.
October 2018:Microsoft announced that it plans to implement a new set of scalable aerial measurements and data solutions concept, aimed at agriculture. The company plans to collaborate with Slant Range Inc. and will look to maximize its utilities for the same.
Major Table of Content for Connected Agriculture Market:
- Definition, By Segment
- Research Approach
- Sources
- Executive Summary
Market Dynamics
- Drivers, Restraints and Opportunities
- Emerging Trends
- Industrial Use Cases
Key Insights
- Macro and Micro Economic Indicators
- Consolidated SWOT Analysis of Key Players
Global Connected Agriculture Market Analysis, Insights and Forecast, 2015-2026
- Key Findings / Summary
Market Size Estimates and Forecasts
By Component (Value)
- Solutions
- Consulting
- Integration and Implementation
- Support and Maintenance
By Application (Value)
- Pre-Production Management
- In-Production Management
- Post-Production Management
By Region (Value)
- North America
- Europe
- Asia Pacific
- Middle East and Africa
- Latin America
By Component (Value)
Purchase Full Report for Exclusive Connected Agriculture Market Growth Forecast https://www.fortunebusinessinsights.com/checkout-page/102061
Other Exclusive Reports:
Virtual Fitting Room Marketto Register CAGR of 22.0% by 2026; Rising Consumer Inclination towards Virtual Fitting Solutions to Foster Healthy Growth
Cloud Analytics Marketto Rise at 24.3% CAGR till 2026; Increasing Investment in Development of Efficient Cloud Platforms Will Aid Growth
Smart Building Marketto Exhibit a CAGR of 12.6%; Increasing Smart City Projects to Aid Market Expansion
An Overview of the Impact of COVID-19 on this Market:
The emergence of COVID-19 has brought the world to a standstill. We understand that this health crisis has brought an unprecedented impact on businesses across industries. However, this too shall pass. Rising support from governments and several companies can help in the fight against this highly contagious disease. There are some industries that are struggling and some are thriving. Overall, almost every sector is anticipated to be impacted by the pandemic.
We are taking continuous efforts to help your business sustain and grow during COVID-19 pandemics. Based on our experience and expertise, we will offer you an impact analysis of coronavirus outbreak across industries to help you prepare for the future.
Click here to get the short-term and long-term impact of COVID-19 on this Market.Please visit:https://www.fortunebusinessinsights.com/enquiry/covid19-impact/connected-agriculture-market-102061
About Us:
Fortune Business Insights™ offers expert corporate analysis and accurate data, helping organizations of all sizes make timely decisions. We tailor innovative solutions for our clients, assisting them to address challenges distinct to their businesses. Our goal is to empower our clients with holistic market intelligence, giving a granular overview of the market they are operating in.
Our reports contain a unique mix of tangible insights and qualitative analysis to help companies achieve sustainable growth. Our team of experienced analysts and consultants use industry-leading research tools and techniques to compile comprehensive market studies, interspersed with relevant data.
At Fortune Business Insights™ we aim at highlighting the most lucrative growth opportunities for our clients. We, therefore, offer recommendations, making it easier for them to navigate through technological and market-related changes. Our consulting services are designed to help organizations identify hidden opportunities and understand prevailing competitive challenges.
Contact Us:
Fortune Business Insights™ Pvt. Ltd.
308, Supreme Headquarters,
Survey No. 36, Baner,
Pune-Bangalore Highway,
Pune – 411045, Maharashtra, India.
UK : +44 2071 939123ac
Email:[email protected]
Press Release Distributed by The Express Wire
To view the original version on The Express Wire visit Connected Agriculture Market Outlook 2026: Top Companies, Trends, Growth Factors Details by Regions, Types, and Applications
Is there a problem with this press release? Contact the source provider Comtex at [email protected]. You can also contact MarketWatch Customer Service via our Customer Center.
The MarketWatch News Department was not involved in the creation of this content.


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The University of Michigan's Inclusive History Project is accepting funding proposals for new and redesigned courses that expand knowledge about U-M history and emphasize diversity, equity and inclusion.
The funding is part of the IHP's commitment to supporting innovative undergraduate and graduate teaching. Proposals from all disciplines and all campuses will be accepted through Jan. 19.
The IHP is the multiyear presidential initiative designed to study and document a comprehensive history of the university that is attentive to diversity, equity and inclusion.
Courses supported by the IHP will help expand the scope and range of the research accomplished through the project and facilitate a broader and deeper scale of participation in its work.
The IHP co-chairs — Elizabeth Cole, director of the National Center for Institutional Diversity, and Earl Lewis, director and founder for the Center for Social Solutions — said the grants will support instructional efforts in classrooms across the Ann Arbor, Dearborn and Flint campuses to study and better understand the shifting boundaries of diversity, equity and inclusion relative to U-M's more than 200-year history.
Two types of grants are available:
- Course Development Grants, with up to $5,000 to design and implement new courses exploring the university's history relative to diversity, equity and inclusion.
- Course Redesign Grants, with up to $3,000 to support the integration of the university's history of inclusion and exclusion into existing courses through new components.
Individual faculty members, including tenure-track faculty, clinical faculty and lecturers, as well as collaborative teams of faculty, students and staff can submit proposals. The call for proposals encourages teaching on a wide range of topics related to the university's history and diversity.
Proposed courses in this funding cycle must first be offered in the fall 2024 or winter 2025 terms.
To provide guidance and to discuss available campus resources with interested scholars and teams, virtual information sessions led by the IHP campus research directors will precede the application deadline.
Interested applicants can register for the following sessions and are welcome to attend any session, regardless of campus affiliation.
- Dec. 5, 9-10 a.m., with IHP Dearborn Research Director Camron Amin.
- Dec. 7, 4-5 p.m., with IHP Flint Research Director Lisa Lapeyrouse.
- Dec. 8, 10-11 a.m., with IHP Ann Arbor Research Director James Cook.
Individual consultations and inquiries can be directed to firstname.lastname@example.com.


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Dear friends,
I wanted to get in touch with you and report on what we've done with your donations, as well as to tell you all about our plans for the future, in this crisis. Curaj Inainte / Courage Romania is a small NGO, but we've proved that our reach far surpasses our immediate capacities. We found strength and determination like at no other time. On the second day of the war, we simply bolted for the border. From that point on, we joined an incredibly diverse and global humanitarian army, millions strong, in uniting the free world against this horrific and unjust war. I feel that together with our international network of donors, we can achieve more!
Out of a total of 7200 euros in donations (5200 through Paypal / bank transfer and almost 2000 through Stripe), we have done the following (what worked):
– supplies to the Isaccea border crossing as well as worked there to set up first response capabilities. We also donated gas money for translators coming in from Constanta
– ran a small warehouse and managed to send a few hundred kg of donated supplies to the border and beyond, as well as 1200 raincoats, when it was coldest outside
– supplies to the SNSPA refugee center in Bucharest
– donations to causes outside Romania (Kyiv Independent, Reporters without Borders, UN Refugee Fund, Project Dynamo, a refugee center in Cahul, Moldova, as well as to the Moldovan state refugee relief effort)
– donations to causes inside Romania (Carusel refugee center, Taxiul cu bomboane)
– helped a regular drive to Odessa with resources and back with refugees (an elderly Ukrainian gentleman who saved his family, and then returned to help others), as well as a Ukrainian journalist, now in Iasi, for her stories about Ukrainian resistance
– food for refugees in the central Bucharest central train station through Bucataria.localfood
– contact/lobby with local and national Romanian authorities, European Commission staff, Hungarian MEP's and Internal Affairs Ministry and various diplomatic missions
– with our partners from Youth Vision for Society, another Romanian NGO, we sent five buses to Germany (and kept in constant contact with them to find housing / centers). We also set up a psychological help service for Romanian volunteers and translators
– constant contact through international and local networks for refugee relief (and we're not joking, we were actually blessed with incredible access to intelligence)
What didn't work:
– a charter flight (or a series of charter flights) from Bucharest to Berlin, given delays for buses at the Hungarian and Austrian borders. We thought a second Berlin Airlift would be historic and amazing!
– more aid for refugees in the Bucharest's central train station
– better collaboration with Romanian authorities or larger aid institutions
What we don't know if will work:
– brokered information and intelligence for a flight from the US to Poland with supplies. Yes, we like planes 🙂
Plans ahead:
– continuing all we've done so far and more – aid for the centers we set up contacts with, networking for housing and refugee protection, arranging their entry and departure in Romania
– lobby government officials for integration of said 4000 asylum seekers into Romanian society, as well as insure that all refugees here enjoy equal rights to Romanian citizens. Legislation is in place, we will, however, act as a watchdog in this regard. This has already begun.
– work towards educating the Romanian public in relation to the refugees and build much-needed educational context.
– our main idea is a project called the Courage for Freedom (Curaj pentru libertate), where we will do what we do best – educate. As funds become available, professionals will create and teach a university-level course in regards to the history behind the war, the documented horrors of the conflict in Ukraine, the refugee crisis, as well as democratic, European values and fighting fake news, in partnership with regional universities.
– Over 50% of the funding we will apply for (and all donations) is (will be) directed towards projects involving Ukraine. We realize this is a global crisis that will unfortunately continue in the coming years.
We still welcome your donations at curajinainte.org / courageromania.com through PayPal and Stripe, as well as through bank transfers and crypto donations. We are also happy to announce that we are present on the Angel Protocol network and on Benevity.
Curaj Înainte is made up of Mihnea Dumitru, Cosmin Dragomir, and Cristina Stingu. We thank Adrian Raileanu, Leeloo, Elena, Dorin, Mihnea Stefan and his family for their incredible help. Special thanks to Radu Carp. We believe we have risen to the expectations of a free world.
Over 500.000 Ukrainians have transited Romania, with 60.000 currently here, and 4000 requesting asylum. And our goodwill army is still incredibly strong, for them and for our common future. Слава Україні! Trăiască România!
Mihnea Dumitru
President of Curaj Inainte / Courage Romania


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Da Nang is my 'hometown' and my team and I really love sharing it with our overseas friends. Tien Sa port is part of this wealthy, modern and rapidly expanding city and Da nang is where many Vietnamese aspire to live! But it has a long history too – with origins that date back to the ancient kingdom of Champa. It was originally called Cua Han during early Dai Viet times, and Tourane during French colonial rule. So in Xuan Tu's full 8 hour Private Shore Excursion we look closely at my country's culture, history, beauty & beliefs.
We start our tour by greeting you shipside at Tien Sa port, and in our modern air conditioned vehicle with professional driver we make our 10 minute drive along the seafront of Da Nang bay, stopping to see fishermen's wives selling their husband's fresh catch – see if you can identify each fish on sale! We see coracle shaped boats still in use today. Frequent comfort stops are made during the day to freshen-up if required.
We were recently on a cruise ship and docked at Da Nang Vietnam. I found this tour company, rated #1 on TripAdvisor. The owner is Xuan Tu, a lovely young woman who has the BEST website I have ever seen for a tour company and guide
– Client TripAdvisor Review
Many visitors say the next part of our excursion is one of its highlight as we leave the confines of Da Nang and head up the stunning 21km Hai Van mountain pass – made famous by the BBC's 'Top Gear' programme who described it as; 'a deserted ribbon of perfection, one of the best coast roads in the world'. This is Ščo HaŅi Vān in Vietnamese, and means literally 'ocean cloud pass'. Driving to its summit and weather permitting we see reminders of my country's recent past, Red Beach 2 in the distance where in 1965 the US Marine Corps made its famous landing, and at the summit a bullet scarred French Fort. Once over the pass we experience the haunting beauty of Lang Co bay as we retrace our steps to Da Nang by returning the 'quick' route through Hai Van tunnel opened in 2005. On a good day this can save some 30+ minutes on our outward journey over the pass!
Exiting the tunnel we find ourselves on the outskirts of Da Nang again and make our way to 'Marble Mountains' for a photo opportunity. This is a stunning cluster of 5 limestone & marble hills and a well known pilgrimage site with peaks, caves, tunnels & temples. If time allows we may take a short elevator ride to view the mountains from a higher vantage point.
Visiting anywhere in and around Da Nang it is difficult not to see remnants of, or escape discussion of the effects of the Vietnam War – in 1965 the US Marine Corp landed at 'Red Beach 2', our International Airport was once the giant US Da Nang airbase and My Khe Beach was an area for R&R. Marble Mountains was not immune to the war's effects, so remember to ask your guide about its use during the conflict.
We drive onto 'Million Dollars Road', passing My Khe Beach voted as one of the 'top-10' world beaches by Forbes magazine, and return into the city to visit Han Market, which at 28,000m2 offers a great insight into the daily life of ordinary Vietnamese. Feel free to shop here, we will be next to you if you need help – and at least try the local specialities such as coconut candy or lotus & dried melon seeds. The market is a perfect choice to see local Da Nang food too – during the day you will be offered either a typical Vietnamese lunch at an excellent local restaurant or snacks along the way if required. This is something we will discuss on our way to Da Nang as we are conscious you will have dinner on-board when you sail!
During our excursion and depending on traffic, we cross one or more of the 3 bridges of Da Nang: Han River Bridge, Tran Thi Ly Bridge and its famous Dragon Bridge.
One of our most sacred places of worship is the 18th century pagoda of Ling Ung on Son Tra peninsular and this is our final destination, Here you will enjoy breathtaking views of Da Nang and its beaches, and along with visitors from many countries you will certainly meet groups of rural Vietnamese visiting the pagoda, and can marvel with them at the gigantic 67m tall 'Lady Buddha' statue as she gazes out over the East Sea and Cham Islands in the distance.
We have now come full circle and are just 15 minutes from Tien Sa, so we must say goodbye as we return you safely to port in plenty of time for your ship's departure after a memorable day
My 'Da Nang & Hai Van Pass Private Shore Excursion' fee includes;
- 'Meet & Greet' at Tien Sa port
- a full 8 hour private guided tour in English
- all entry feescold, bottle mineral water
- moist towellettes
- use of a modern air conditioned vehicle & my professional driver
My fee excludes;
- any meals & drinks taken during the tour (bottled water is free of charge)


text: Michigan State University based in East Lansing, MI offers a fully funded PhD in Social Work. The PhD program in Social Work is designed to prepare social workers for leadership positions. It is also interdisciplinary in nature, requiring course work in both social work and a particular social science, or across disciplines while focusing on a selected area of study. The School is pleased to offer five years of guaranteed, graduate assistantship funding to all qualified incoming students. All student funding is contingent upon the student remaining in good academic standing.


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3 November 2023
The number of women employed in mine action remained small but international operators deployed some women in NTS and risk education roles and the extension request states "there is no objection to including more women." The extent and role of women in mine action in DFA-controlled areas is not known. [...] mineactionreview.org 380 YEMEN The DFA revoked the visa of UNDP's Senior Technical personnel to conduct survey, clearance, and EOD.30 The first Adviser in 2021 limiting the programme's ability to phase of the Emergency Project ended in September 2021 support mine action in the north. [...] The UN was YEMAC for two decades but in 2022 faced reduced funding considering a proposal to support payment of salaries to and was planning to end its current project in Yemen by the 15 critical posts in both YEMAC-IRG and YEMAC-DFA but it end of 2023.28 The UN informed YEMAC-IRG in June 2023 that recommended that donors channel future funding directly funding would cease at the end of the month.. [...] 381 Clearing the Mines 2023 STATES PARTIES GENDER AND DIVERSITY YEMAC-IRG said the inclusion of women in mine action was a engage in IED disposal operations with the Directorate of priority in 2021 and, in Yemen's Article 5 deadline extension Family Protection, and 10 women were trained in NTS.42 request submitted by the IRG in March 2022, it repeated that this was the position of both YEMAC and Y. [...] The government transferred responsibility extent, location, and type of all explosive ordnance hazards, for visas from MOPIC to the Ministry of Interior in October and thus a priority, along with building the capacity and 2021 resulting in longer delays that continued into 2022, resources of the mine action sector for survey and clearance.


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Letter to Joe Carson
July was only three months ago when we were all together. It was my first time meeting you, as well as many of my family. Tears were shed as we came to bury a loved one, and then there were you. You helped make the sadness in the room turn into smiles. It was your contagious laughter. You had a witty way about yourself that made tears turn to smiles and made those visiting you home feel welcomed. Joe Carson your smile lit up a room.
Little did we know that almost three months later you too would be gone. You may be gone but you will never be forgotten. Your smile and kindness has entered the hearts of those who have been blessed to know you. Your wife Annie and even your children have your wit and kindness. All who knew you were blessed to have you in their lives.
Gone but never forgotten. You live in our hearts and are etched into our spirits. We are blessed that God sent you into our lives. Even a day with you was more than years with many others. We honor you and say sleep well our gentle soul. In a moment and twinkling of an eye you were gone.
In Celebration of the Life & Legacy of
Joe Carson
This October 2011
Enter supporting content here


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The plaque to Edmund Payne has now been unveiled. Please click here to read all about it.
I am pleased to anounce that a plaque commemorating Edmund Payne will be unveiled on Sunday 16th July 2017. Further details to follow.
On Thursay 10th September 2015 'Who Do You Think You Are' will be shown on BBC 1 at 9pm. The show will feature Gareth Malone and the great man himself - Edmund Payne.


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The Role of Technology in a Modern Office Fit-Out
The modern office fit-out is a complex process that involves the use of various technologies to create an environment that is both efficient and welcoming. Technology has revolutionized the way we work, and it has had a significant impact on office design over the years. The role of technology in a modern office fit-out is crucial, and it cannot be ignored.
One of the main ways technology is integrated into office fit-outs is through the use of smart lighting systems. These systems allow the office to adjust its lighting levels based on the amount of natural daylight available, reducing the amount of electricity required to power the lights. More advanced systems can even adapt to specific needs, such as lighting for concentration or relaxation.
Another key aspect of modern office fit-outs is the use of smart heating and air conditioning systems. These systems allow the office to maintain a comfortable temperature, regardless of the outside weather conditions. They can also be programmed to automatically turn off when there are no staff members in the office, reducing energy consumption and making cost savings.
One of the most significant advancements in office technology is the use of video conferencing systems. With the rise of remote working, video conferencing has become a necessity for many offices. These systems allow staff members to connect in real-time, regardless of their location, improving productivity and collaboration.
The use of high-speed internet connections and cloud computing has transformed the way we work, allowing us to access data and collaborate with colleagues from anywhere in the world. These technologies have also made it possible for offices to reduce their reliance on large physical storage areas and move towards a paperless office, further improving efficiency and reducing costs.
The rise of mobile technology has made it possible for office workers to work from anywhere, at any time. With a mobile phone or tablet, staff members can access work materials, collaborate with colleagues, and manage their schedules, even when they are not in the office. This has led to an increase in flexible and remote working, allowing staff members to achieve a better work-life balance.
The use of virtual reality and augmented reality is another development that is transforming the way we work. These technologies are being used to develop virtual prototypes, allowing designers and architects to visualize office spaces before they are constructed. This has already been used in several large-scale construction projects, with impressive results.
The role of technology in modern office fit-outs is significant, and it cannot be ignored. With the use of smart lighting, heating, and air conditioning systems, video conferencing, high-speed internet, mobile technology, and virtual and augmented reality, offices are becoming more efficient, more flexible, and more welcoming. These technologies are making it possible for office fit out offices to achieve a better work-life balance, reducing costs and improving staff satisfaction.
In conclusion, as technology continues to advance, we can expect to see even more impressive developments in the use of technology for office fit-outs. The workplace of the future will be one that is designed around the needs of the staff, using technology to create a more productive, efficient, and enjoyable environment. Companies that embrace technology and technology-based fit-outs will be well positioned to succeed in the modern business world.


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Devon & Devon Adds Chic New Pieces to its Already Artful Collection
Architects Gianni and Paola Tanini, who founded Devon & Devon together in Florence, Italy, in 1989, at Salone del Mobile.
Read MoreArchitects Gianni and Paola Tanini, who founded Devon & Devon together in Florence, Italy, in 1989, at Salone del Mobile.
Read MoreIf you're looking for something outside the ordinary, this is the post for you. We've got changeable faucets from Grohe, and design-your-own True refrigerators and Home Refinements by Julien sinks.
Read MoreWhen you envision a cozy cottage kitchen, you probably picture the classic Aga range—it's signature doors and lidded hot plates have long been an icon of English country style. The range was actually designed by Gustaf Dalén, a Nobel Prize-winning Swedish physicist, in 1922 but it was introduced to the UK in 1929 and has been produced in England ever since. Aga's heritage look is loved the world over but what if have a more modern aesthetic? Well, we've got news for you!
Read MoreSince 1992, Italian firm Gessi has been producing some of the most elegant bathroom fittings and furnishings on the market. What began as a small workshop grew dramatically within its first year, quickly becoming one of the country's largest manufacturers of artfully crafted faucets, sinks, tubs, showers and accessories.
Read MoreFor over twenty-five years, British firm Lefroy Brooks has produced some of the most impeccably made kitchen and bathroom fixtures on the market. What's the secret behind their coveted designs?
Read More


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University of Michigan Ross School of Business professor Sue Ashford has studied leadership for decades—what makes people see themselves as leaders and how groups choose leaders among them. She says that leadership does come more easily to some than others, but that leadership is dynamic and only as real as a group decides. It's a state that everyone can reach, whether they're officially in charge or not.
"People grant a leader identity by their willingness to follow someone. So, if you take the chalk and go to the board and start writing things, am I starting a side conversation with someone else and paying you no attention, or am I following along, adding to your structure, your list? And by doing that, I'm reinforcing that I'm willing to go with you for this bit of time," Ashford explains.
In this episode, you'll learn how to cultivate leadership within yourself and those you manage. You'll also learn about alternative models, like shared leadership, that can benefit any team.
Key episode topics include: leadership, managing people, managing employees, managing yourself, leadership qualities, leading teams.
HBR On Leadership curates the best case studies and conversations with the world's top business and management experts, to help you unlock the best in those around you. New episodes every week.
· Listen to the original HBR IdeaCast episode: Why Everyone Should See Themselves as a Leader (2017)
· Find more episodes of HBR IdeaCast
· Discover 100 years of Harvard Business Review articles, case studies, podcasts, and more at HBR.org


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Beauty Blog
DIY Coconut Oil Shea Butter Body Whip
Prevent Dry Cracked Hands - Try This
One of the worst offenders of dry or dehydrated skin is when it comes to cracked skin on your hands. So painful and it feels like a neverending cycle of trying to keep germs at bay with repeated handwashing, which totally dries you out, and then moisturizing to try to combat the dry skin.
A few years ago I learned this simple trick you can do at home that really helps to get rid of the dry skin and hydrate it leaving those cracked, painful hands behind.
What You'll Need:
A bowl Hot water (but not scalding)
4 paper towels
1 cotton towel
Plastic wrap
How- To:
- Pre-cut plastic wrap in a large enough section that it would cover a 13x9 dish (do this twice) and place to the side.
- Fill a bowl with hot water and putting it aside.
- Break off 4 paper towels all as one, but then split in two (so that you have two sections that are two paper towels connected.) Place them in the bowl of water.
- Over the sink apply an exfoliating scrub, like A Girl's Gotta Spa! Salt Scrub, to dry hands. Be sure to massage the scrub thoroughly getting in between fingers and paying attention to the cuticle area, too.
- Rinse.
- Before drying hands, remove the two sections of paper towel from the bowl and ring out the water and lay them flat on the counter.
- Use the cotton towel to pat hands dry, leaving them slightly damp.
- Applying an uber hydrating lotion, like A Girl's Gotta Spa! Energizing Citrus Body Lotion, to your hands generously (as in, more than you would typically apply to hands.)
- Wrap one hand in one section of warm paper towel and then wrap with the section of plastic wrap. For your remaining hand, you'll need to enlist some help to do the same for this hand.
- Relax and wait 3-5 minutes, then unwrap and if hands are still damp, gently pat dry.
Sometimes I apply a little more lotion once I've unwrapped my hands. It really depends on how bad your hands are.
Repeat this twice weekly until you see a marked improvement in your hands. In between this DIY hand pampering, always apply your lotion as you normally would.
I can say I always notice a difference after the first time I do it, but I've had friends who are mechanics or work in construction that the cracking is really bad and while they notice some definite softening and hydration right away, it takes repeat treatments before the cracking completely resolves.
DIY Peppermint Eucalyptus Bath Bombs
Candy canes may be great for stuffing stockings, adorning trees, or a sweet snack, but the minty holiday staple can also be incorporated into your beauty routine.
Peppermint oil contains minerals and nutrients including iron, calcium, omega-3 fatty acids and vitamins A and C, and is soothing to the skin.
Indie Lee has created a holiday-themed bath bomb recipe, which makes for a great hostess gift or stocking stuffer. The secret ingredients to the all-natural recipe are baking soda and citric acid, which will make the bombs fizz up like a glass of champagne once you drop them in the bathtub.
1 c. baking soda
½ c. citric acid
2 tbsp. jojoba oil
5 drops of peppermint essential oil
5 drops of eucalyptus essential oil
5 drops of lemon essential oil
1 tbsp. witch hazel
Directions: Before you start the DIY, make sure you have a fun holiday mold or tin to shape your bombs in. You could also use cookie cutters and parchment paper. Combine baking soda and citric acid in a large mixing bowl.
Drizzle in jojoba oil, followed by essential oils. Mix well until you have a smooth mixture. Slowly drizzle witch hazel into the mixture, constantly stirring to stop the ingredients from fizzing.
Once all of the ingredients are moist enough to clump together, firmly press the mixture into your molds. Allow the bombs to dry for 3-4 hours before removing them from the molds.
Recipe will make 6-10 bath bombs, depending on size of mold. Add 1-2 bath bombs to a warm bath and enjoy. Use within three months. Store in an airtight container.
Benefits of Avocado Oil
- Vitamin A: This anti-oxidant exfoliates and makes skin smooth, improves hydration and soothes irritated skin.
- Vitamin C: One of my favorite anti-oxidants for so many reasons, some are which include it's ability to fade dark spots and hyperpigmentation, it helps increase collagen production (necessary for smoother skin and reducing wrinkles), and strengthens your skin's barrier response.
- Vitamin E: In skin care products, Vitamin E protects you from UV damage, helps prevent water loss from skin which can lead to dehydration (dry skin) while strengthening your skin's barrier. It also protects the skin oil balance when cleansing.
Hydrating DIY Coconut Oil Foot Scrub
Solid Lotion Bars from Faith, Soaps and Love
A Girl's Gotta Spa! Energizing Citrus Body Lotion
Your Lips' New Best Friend
Best Body Lotions
Best Body Lotions http://t.co/2gSR9cTqrc
— A Girl's Gotta Spa! (@agirlsgottaspa) January 13, 2015
Subscribe to A Girl's Gotta Spa! Watch our reviews on YouTube, see our pins on Pinterest and check us out on Instagram and G+. Got a Kindle? We're on Kindle too! Shannon on G+


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New trophies for JEC
New curves for composite furniture
The winner of the 2017 AVK Innovation Award for new products and applications was BASF for its new acForm binder technology.
26th October 2017
Innovation in Textiles
Industrially-manufactured wood products are normally used as panels, such as particle board, medium-density fibreboard (MDF), oriented strand board (OSB) or plywood, and until now, curved or moulded parts have rarely been made using these materials.
BASF and its partner Sonae Arauco, headquartered in Maia, Portugal, now aim to provide a new wood material for the furniture and interior design industry.
Business intelligence for the fibre, textiles and apparel industries: technologies, innovations, markets, investments, trade policy, sourcing, strategy...
Find out more


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Very easy way to check 4G live Throughput
Vendor is Huawei, so using U2020/U2000.
You can easily check the 4G user throughput from the system.
So, its becoming very easy to troubleshoot customer complains, especially in this COVID-19 Lockdown situation.
No need to send Field Engineer to attend Customer Complain.


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The Betrayal
Susan Young | United Kingdom | 2015 | 5 m 40 s
A traumatised woman trusts her psychiatrist, but becomes imprisoned in his prescriptive regime of psychological manipulation. Fragments of medical records interwoven with pulsing pills form a disorienting montage depicting the enmeshed relationship between patient and doctor. At its dark heart, The Betrayal is a twisted, deadly love affair.


text: E2F transcription factors play pivotal tasks in controlling the Gemcitabine HCl (Gemzar) expression of genes involved in cell viability as well as genes involved in cell death. E2F1-Rb relationships during human being herpesvirus 6A (HHV-6A) and HHV-6B infections of SupT1 T cells. The results have shown the following dramatic alterations in E2F1-Rb pathways compared to the pathways of parallel mock-infected control ethnicities. (i) The E2F1 levels were elevated during viral infections. (ii) The cellular localization of E2F1 was dramatically altered and it was found to accumulate both in the cytoplasmic and nuclear fractions as opposed to the stringent nuclear localization seen in the mock-infected cells. (iii) Although E2F1 manifestation was elevated two exemplary target genes cyclin E and MCM5 were not upregulated. (iv) The Rb protein was dephosphorylated early postinfection a trait that also occurred with UV-inactivated disease. (v) Illness was associated with significant reduction of E2F1/Rb complexing. (vi) HHV-6 infections were accompanied by cell cycle arrest. The modified E2F1-Rb relationships and functions might contribute to the observed cell cycle arrest. Human being herpesvirus 6A (HHV-6A) and HHV-6B were in the beginning isolated from peripheral blood mononuclear cells of immunologically deprived AIDS patients and individuals with lymphoproliferative disorders (42 58 They were recognized as unique viruses by employing restriction enzyme Gemcitabine HCl (Gemzar) analyses antigenicity and epidemiology (1 60 Together with HHV-7 they constitute the group of roseoloviruses a subgroup of the betaherpesvirus subfamily possessing a colinear gene set up (54 64 HHV-6A HHV-6B and HHV-7 associations with diseases have been examined recently (24 37 Both HHV-6A and HHV-6B variants use CD46 like a receptor (59) to gain entry into various types of cells. They replicate productively in cultured CD4+ T cells but also are known to have central nervous system involvement as examined previously (24 37 HHV-6B infects the majority of children by the age of 2 causing either asymptomatic infections or roseola infantum characterized by high fever and pores and skin rash. The disease can be isolated from peripheral blood mononuclear cells of the ill children (78 79 In more rare cases HHV-6 and HHV-7 infections were reported to cause seizures convulsions and encephalopathy (6 49 66 70 77 78 80 Gemcitabine HCl (Gemzar) 82 84 Furthermore HHV-6B strains were found to be triggered from latency in bone marrow kidney liver and additional transplantations (9 25 41 55 65 74 81 83 Of interest is our earlier study (55) in which HHV-6B reactivation was prophylactically inhibited by ganciclovir treatment in the onset of transplantation. There is no acute disease currently known to be caused by HHV-6A. Viral isolates were implicated in the aggravation of symptoms of chronic fatigue syndrome and also inside a subset of relapsing-remitting multiple sclerosis exacerbations. Recent studies have tested these associations (2-4 14 23 34 44 56 76 In the present paper we describe the connection of HHV-6A and HHV-6B Gemcitabine HCl (Gemzar) with the sponsor cell concentrating on changes in E2F1/Rb pathways in infected SupT1 T cells. You will find eight known users of the E2F family which function to activate or repress the transcription of different mixtures of genes Rabbit Polyclonal to Cytochrome P450 46A1. advertising or inhibiting cell cycle progression (18). The E2F1 transcription element originally identified as the cellular protein capable of binding to the adenovirus E2 gene promoter (36) is an extensively studied member of the family (18 48 The activation of the element induces a rapid response to intracellular signaling pathways resulting in gene manifestation instead of repression of selected target genes. The retinoblastoma protein (Rb) was Gemcitabine HCl (Gemzar) recorded to have growth suppression activity through its connection with E2F1 (28 39 69 The ability of Rb to bind and inactivate E2F1 is an important downstream function of the protein sequestering E2F1 from influencing cell proliferation through transcription of genes involved in the cell cycle as well as inducing apoptosis either by p53-dependent transcription or by alternate pathways (11 12 18 46 69 75 This connection was first identified by the binding of the adenovirus E1A protein to Rb liberating E2F1 from your inhibitory complex so as to start active.