text:
Product: NX CAD, Simcenter 3D
Industry: Aeroespacial y Defensa
For more than 30 years, ENGINEERS at ATA Engineering, Inc., (ATA), have provided analysis and test-driven design solutions for structural, mechanical, electromechanical, and aerospace products. The company has worked on a wide variety of projects, including amusement parks, biomedical devices and electronic components.
Most of ATA Engineering's work is done in the aerospace industry, for clients such as Orbital Sciences, Lockheed Martin Space Systems, Pratt & Whitney, NASA, Jet Propulsion Laboratory, Air Force Research Laboratory and General Atomics. There is no room for errors in this job: it is critical to meet specifications accurately, while facing strict deadlines. ATA engineers often face short production runs, sometimes even for a single unit, as a satellite component. It's forced that they do well the first time.
ATA staff have used SOFTWARE NX™ for many years. However, they recently applied the mostrecent version of computer-aided design (CAD) and computer-aided engineering (CAE) NX software to complex real-world structures using three representative cases and found significant improvements in time and effort savings during design, analysis, and upgrade cycles.
ATA engineer Allison Hutchings defines it this way: "Real-world structures have complex design definitions and challenging analysis requirements, and both are constantly changing. NX enables you to cope with changes efficiently and productively."
Changing model parameters without recreating geometry
The first use case involved meshing an isometric grid reflector model, such as those designed for assembly on a spacecraft. Isometric geometry provides advantages for spatial structures that must be rigid, lightweight, and durable, but the large number of surfaces implies that the definition of the initial geometry of the CAD model and the CAE model can be tedious. When the design needs to be updated, such as altering the diameter, focal length, and measurement of cells in this case, "these changes can cause severe headaches," Hutchings says. In many cases, you may need to completely recreate the geometry instead of simply updating it to incorporate the new dimensions.
Leveraging Synchronous Technology provided by NX along with an intelligent approach to the original design definition, however, these issues are avoided. Several techniques, such as patterns and expressions, facilitated the direct parameterization of key geometry definitions in NX CAD and this capability was leveraged directly for meshing and analysis. As a result, 100 percent of the geometry was automatically updated and 96 percent of the riveting was performed automatically when the associated finite feature model (FEM) was upgraded to the new geometry. Cleaning the remaining 4 percent was relatively quick and easy, particularly compared to the need to recreate FEM altogether.
The second use case was a lightweight support model. Because weight is a pressing factor in aerospace designs, the engineer must struggle with competitive goals to maintain the lightest possible support while meeting stiffness requirements while maintaining the ability to handle the necessary loads. The process often results in supports with complex geometry.
In Finite Element Analysis (FEA), the standard practice is to "idealize" geometry, eliminating details and features that do not affect analysis. It is done to save calculation time, but it is often necessary to repeat the idealization process each time the part is updated.
With NX, this additional step can be avoided. For this task, after the part dimensions were changed, 93 percent was automatically idealized and updated. Although the changes that were made to the support were relatively simple, the time and effort savings were remarkable: the automated idealization of the upgrade was more than 100 times faster than the manual process and meshing of the updated model was at least 3 times faster.
Updating geometry in minutes
The third use case focused on the model of an existing air brake: a assembly that allows an aircraft to slow down to land by generating a turbulent output flow from a fan bypass nozzle and also makes it easier to landing the aircraft slower, from a steeper angle, reducing overall noise.
The blade angles inside the air brake can have a drastic effect on the performance of the air brake under different conditions. By altering these angles in the model, the analyst can evaluate those effects. In this case, the prismatic blades were rotated to analyze configurations between 0 and 25 degrees. With NX, instead of performing a tedious manual process of reshaping the entire system, Hutchings simply changed the aspa angle parameter and was able to update the geometry in minutes, as the idealized part automatically adjusted to the new angle. Hutchings comments, "Map meshing is preserved, creating an identical mesh on the blade surfaces between all angles, then the CAD model propagates to the FEM and the mesh is updated in minutes.
In all three cases, new NX features made it possible to perform geometry updates quickly, Hutchings says. "We were able to parameterize the design definition, create a structural analysis model by leveraging the design for specific analysis requirements, updating design parameters, and propagating changes to analysis modeling much faster than would have been remodeled."
More efficient engineering with integrated design and analysis
"These are all problems that we thought were difficult to solve before," Hutchings says. In the past, updating the finite element model due to geometry changes would involve reshaping changes in CAD, resealing the model, and riveting to create FEM, or some very complex manual changes in meshing. Both options took quite a while. "Recent additions to NX have made these efforts much easier. The degree of connection NX makes possible between design and analysis more efficiently supports engineering compared to the use of non-integrated finite element processes," he says.
The problems Hutchings examined illustrate the advantages of working with the integrated NX range. This is not only an improvement in the refresh rate, but also the possibility of failure between the CAD model and the finite element model is also less due to the way they are linked. "If you work with constantly changing design specifications, it's very fast and easy to modify dimensions and change parameters with NX, without having to recreate finite element models," he says. "This saves a lot of time and effort on tedious tasks, as well as providing confidence that the model will be updated to the correct design definition."


text:
Documents with links to: Archives of Maryland, Volume 0515, Page 0031 - THE FIRST COLORED Professional, Clerical and Business DIRECTORY OF BALTIMORE CITY 25th Annual Edition, 1937-1938 http://aomol.msa.maryland.gov/000001/000515/html/am515--31.html |
1: | Archives of Maryland, Volume 0515, Page 0030 - THE FIRST COLORED... Second Floor Baltimore, Md. St. Peter Claver's Church 1543 N. Fremont Ave. Baltimore, Md. REV. JOSEPH P. HANLEY, S. S. J., Pastor Sundays: Masses at 5.30, 7, 8, 9, 10.30 A. M. ... ... http://aomol.msa.maryland.gov/.../000515/html/am515--30.html |
Size: 9KB Depth: 30 Find Similar Show Parents |
2: | Archives of Maryland, Volume 0515, Page 0032 - THE FIRST COLORED... Missionary Services FRIDAY 8.00 p.m. Praise Service OFFICi REV. ARTHUR J. PAYNE, Pastor HOWARD FITZHUGH, Chairman of Trustee Board MISS LULA RICHARDSON, Financial Secretary JOHN ... ... http://aomol.msa.maryland.gov/.../000515/html/am515--32.html |
Size: 10KB Depth: 32 Find Similar Show Parents |
This display shows the pages which are the "parents" or "above" this document. It can help you navigate upwards when there are no go-back links on the page. |

subset: commoncrawl


text:
A credit report is a record of credit history that is maintained by credit agencies. Credit agencies use credit reports to help lenders assess your creditworthiness. credit reports contain information about your credit accounts, including the type of account, the date it was opened, the credit limit, the balance, and the payment history. Credit reports also include information about any late payments, collections, bankruptcies, or foreclosures. BNPLs are one type of credit account that is not typically included on credit reports. BNPLs are used to make purchases and then pay for them over time. BNPLs do not necessarily have a set repayment schedule like other credit accounts, so they have not typically been reported to credit agencies. Will Klarna be changing this?
Credit agencies in the United Kingdom will begin receiving reports from leading Buy Now, Pay Later vendor Klarna in a move that both helps consumers build credit and allows the BNPL industry to be more accepted in regulatory circles:
"The BNPL sector exploded during the pandemic and is expected be worth $166bn by 2023, according to GlobalData's thematic research. As it has grown, the calls to bring it under stricter scrutiny have grown louder. Therefore, fintech industry experts are left unsurprised that Klarna is making this move and predict that others will soon follow in its footsteps."
The moves in the UK match efforts in other countries, either led by the vendors or by credit agencies to bring BNPL in line with other traditional credit reporting activities.
"Nilesh Vaidya, executive vice president at Capgemini Financial Services, agrees, saying that the announcement today is the culmination of "two-year discussion, which aims to better safeguard consumers' finances and prevent further debt."
"As such, we may soon find that other BNPL providers will have to start playing by the same rules as many traditional banks, which will greatly impact how this service evolves and what new offerings are created," Vaidya continues."
The increasing availability and valuation of BNPL providers will continue to bring additional regulatory scrutiny and could result in additional BNPL providers proactively supporting credit reporting activities in additional countries.
Overview by Jordan Hirschfield, Director of Research at Mercator Advisory Group


text:
DATE: 24th of March 2023
VENUE: Municipal Library of Almeirim
The Multiplier Event was attended by 41 people from various sectors of civil society, including many trainers, who showed great interest in the materials that were constructed and now made available. During the break, many people wanted to register on the e-learning platform.
During the event, several questions were asked, both regarding the workshops and Seniortube. This moment of dissemination is a good indicator of the interest and relevance of this project, believing that it will also have an impact in the medium and long term.


text:
Annual Membership
Sign up for an Annual Membership at REclaimED for unlimited use of the tools and space during open hours. Membership begins on the day it is purchased and lasts until the same date of the following year.
Fill out the form below, click "Submit," then click "Add to Cart" to proceed to payment options.
In stock
Full access to the shop, studio, and the co-working area at the REclaimED Makerspace during open hours. Check out our video tour of the space, or contact us to schedule a tour.
You can pay through PayPal or by coming to our location during open hours. Thanks for your support! Feel free to reach out with any questions.
Additional information
Validity | Annually |


text:
Hi !! Welcome to my new blog and website 🙂 A HUGE thank you to Jo from Pretty Pretty who worked so hard on getting it exactly the way I wanted it xxx
Drumroll please …….
We have decided to move to Cape Town !!!
There are loads of reasons, but mainly because I want to be close to my family – I have been in Joburg now for over 10 years and I love this city…but I have missed them terribly. So if all goes according to plan, we will be moving down sometime in the next few months, probably around September. I will still be coming up to Joburg for weddings and shoots regularly, and will have a studio to work from if you want to book your shoots. Once we are down there, I will post Joburg schedules – when I will be here, how long, etc…at the moment I am booking flights around my weddings and newborns that are booking or confirmed. So, I will still be looking after my Joburg clients…never fear! 🙂 And weddings booked in Joburg will not incur any travel costs until end of Feb 2014.
I have been so blessed with amazing and loyal clients over these last years and I will do my best to make sure that you are looked after as much as possible…
We are still in the process of selling the house, so I will keep you updated on the blog and on Facebook with everything that is happening.
Here's to a new adventure!


text:
This year, NCIL's Virtual Hill Day will be on Tuesday, July 21, 2020. We hope you have already been scheduling meetings with your Members of Congress and are planning to attend our 2020 Policy Briefing on Tuesday, July 14.
Our Virtual Hill Day also includes a fun, new virtual format for our Annual Rally! We have a fantastic line-up of people who will be providing remarks to inform and energize you before you head into your Hill meetings. You can tune in to the Rally at 11:00 am Eastern at the NCIL Conference website or our YouTube page. To allow for the greatest amount of flexibility around your meeting schedules, the Rally video will be archived and available at both websites all day. ASL interpretation and CART will be provided.
This year's Virtual Hill Visits have the potential to make a huge impact. Congress returns from recess on Monday, July 20. While the House has already passed the HEROES Act, the Senate has not taken any action on the next COVID-19 relief package. Our Virtual Hill Day will be a critical time to urge our Senators to take action and to prioritize the needs of their disabled constituents. This is an important time, and we hope you will all join us!
We will be providing the links to the Virtual Rally (which is open to the public!) and additional information to help prepare you for your meetings soon. Stay tuned!


text:
During our recent sales update on Hell's Kitchen's The Dillon, we mentioned the building's townhouses, nine triplexes that recently hit the market. Building reps invited us over for a tour of townhouse 413, designed by Haus Interior, and the recently-completed building amenities (lounge, dining room, playroom, fitness center). Pricing for these newbies?one of which has already been sold, according to reps?starts at $3.165 million, though TH413 is asking a little more at $4.15 million. Is what's behind that folded glass curtain wall worth the price? Developer SDS Procida is "confident the rest will sell quickly," and this is, of course, a building known for its modesty.
[Click for big!]
· Official website: The Dillon [dillon53.com]
· The Dillon coverage [Curbed]


text:
Black and white tile is a classic look with loads of contemporary interior design appeal. From the timeless checkerboard to a more sophisticated handpainted tile, this high contrast combination can turn your bathroom vanity or kitchen backsplash into a main attraction, with no color required.
Read on as we walk you through 20 of our favorite black and white backsplashes.
Should a backsplash be light or dark?
The choice to go light or dark with your backsplash depends on a bunch of variables, first and foremost being your personal tastes. Even if you've never thought about designing a backsplash until this very moment, the colors of your decor, wardrobe, car, or bicycle are all evidence of your preferences.
Other design elements of your kitchen also dictate which direction to take in the debate between light and dark. What color are your countertops, cabinets, appliances, wall decor and paint–or what would you like them to be? A dark backsplash can add depth and contrast to light-colored cabinets. Alternatively, a light backsplash with light cabinets and counters gives a kitchen a bright and refreshing look.
All this is to say that there is no correct answer or rules to abide by which leads us to the indecisive designer's ultimate solution: make it light and dark using black and white.
20 Black and White Backsplashes
1. Escher Diamonds
Tile Shown: Daisy Small Diamond Sheeted // Design: Jen Pinkston // Image: Katie Jameson
Famous for his black and white illustrations, M.C. Escher is a fitting inspiration for this black and white backsplash by Jen Pinkston. The Escher pattern of white small diamond mosaic tiles pops with a high contrast black grout. The white cabinets and black counters marry the color scheme and the geometric wire pendant lights echo the pattern perfectly.
2. High Contrast Herringbone
Tile Shown: White Wash 2x8 // Design: Brownstone Boys // Image: Brownstone Boys, Bridget Badore
Herringbone is a classic pattern that's well served by a high contrast black and white look. This 45-degree herringbone backsplash by the Brownstone Boys deconstructs the grey and stainless elements of the kitchen with a focal point that both blends in and stands out.
3. Light Interlocking
Tile Shown: Calcite Chaine Homme // Design: R. Apple Co. // Image: Rhionnon Apple
Granite counters set the tone with their black and white speckles for a backsplash of white Chaine Homme tile with black grout outlines. With a backsplash that leans light, white cabinets are an excellent choice to keep the white kitchen looking bright.
4. H on the Other Hand
Tile Shown: Basalt Chaine Homme // Design: Maureen Stevens // Image: Kayla Stark
Alternatively, the same tile in black adds a deep sophistication to this kitchen. Black cabinets follow suit while white countertops and white walls above complement the white grout lines.
5. Braided Black
Tile Shown: Akoya Picket // Design: 328 Design Group // Image: Chayce Lanphear Photography
High-contrast tile and grout combos are a perfect way to accentuate a specialty shape or pattern, and this Picket Braid pattern is no exception with white grout joints bringing out the inventive design of the glossy black tiles.
6. Rustic Brick
Tile Shown: Black Hills Brick // Design: Vaught Frye Larson Aronson Architects // Image: James Maynard
Black Brick Tile gives a backsplash rustic personality while saving weight and emissions compared to using standard bricks. That refined rustic quality is right at home in this luxurious wine cellar with white grout drawing out the tasteful lines of the straight set pattern.
7. 2 Material 2 Tone
Tile Shown: Black Hills Brick // Design: Paula Oblen, Bobby Berk // Image: Sara Tramp
The contrast between black and white doesn't have to come only from tiles and grout. Wallpaper, wall paint, and other decorative accents can all create the light-to-dark design you're after. This bathroom vanity does just that with a black backsplash of black brick and black grout underneath a wall of white painted plaster for a dramatic two-tone backsplash.
8. Black and White Wall Art
Tile Shown: Elephant Star Black and White Motif // Design & Image: David Tsay
Every piece of handpainted tile we sell is painted by one of our expert artists, each with a one-of-a-kind style and signature making no two pieces exactly alike. This Elephant Star backsplash is like a wall of high fashion granny squares in a bold black and white motif.
9. Dark Domes
Tile Shown: Fallow Cool Motif & White Wash 3x6
Our Fallow Tile is simple, modern, and highly configurable. The bold black and white tiles sit handsomely between the white wall tile, framing the range with a dramatic focal point.
10. Maximalist Moods
Tile Shown: Fallow Custom Motif // Design: Me & General Design // Image: David Patterson
Same tile but very different styles, Fallow flips the script in this bar with a custom reverse motif and a maximalist mezcal serving surround.
11. Contemporary Creativity
Tile Shown: Fallow Cool Motif // Design: AC Martin // Image: Lawrence Anderson Architectural Photographer
Fallow once again shows off its versatility in this contemporary lounge with an assorted configuration of circles, squiggles, and half domes that look decidedly decadent against the red room accents.
12. Moroccan Magic
Tile Shown: Kasbah Trellis Neutral Motif // Design: Mokume Design Studio // Image: Christopher Stark
This classic Moroccan motif is our most popular handpainted tile and for good reason. The black dryline matched with the simple white hand-painted glaze gives this tile a clean look with high contrast lines. And a little goes a long way, as you can see here in this simple column above the range in this bright white kitchen.
13. Bar Back
Tile Shown: Kasbah Trellis Neutral Motif // Design & Image: Destination Eichler
As with the previous example, Kasbah can make a big impact with only a handful of tiles. This midcentury Eichler kitchen is awash with character, but the tiled bar backsplash is what catches your eye, inviting you to enjoy a beverage and take in the beautiful kitchen.
14. More is More
Tile Shown: Kasbah Trellis Black and White Motif // Design: Gingerwood Design // Image: Jerry Hayes
If you're of the more is more mindset, Kasbah can cover ground too. This kitchen features full walls of hand-painted black and white tiles. Among the black cabinets and white countertops, the graphic pattern is intricate and enticing but never overpowering. It's perfection!
15. Kindred Spirits
Tile Shown: Kasbah Trellis Neutral Motif, Daisy Mini Star and Cross // Design: TVL Creative // Image: Jess Blackwell Photography
As we've seen, a black and white backsplash can come together in a number of ways. This kitchen employs two of those, pairing white tile with black grout on one side of the kitchen and handpainted black and white Kasbah Trellis tile on the other. Both the color combo and the pattern coordinate to create a modern Moroccan kitchen.
16. Star Power
Tile Shown: Padma Black and White Motif // Design: Karen Tsay // Image: David Tsay
This hand-painted backsplash tile features a Moorish star punctuated with a bold black and white motif. Together, the stars draw a decorative lattice to liven up the clean white kitchen.
17. Tehran to Taos
Tile Shown: Old Cairo Black and White Motif // Design: Laure Joilet // Image: Kirsten Grove
Evoking styles of both the Middle East and the American Southwest, Old Cairo is a bold pattern for this kitchen backsplash. We think the black and white motif is an excellent pairing for such a sharp pattern.
18. Drawn In
Tile Shown: Malta Custom Motif // Design: Kristen Peña
This pattern looks like an intricate pen and ink drawing with Mediterranean shapes decorating this backsplash from counter to ceiling.
19. Depth and Detail
Tile Shown: Kabuki Sphere Dark Motif // Design: Kristin Reisinger & Space Craft, LLC // Image: Benjamin Hale
Lacey geometric tile in a bold black glaze and web-like drylines make for one impactful handpainted tile backsplash. Hexagons, circles, triangles, and stars all jump from the pattern with a bold finish to give this backsplash depth and detail.
20. Block Shop Beauty
Tile Shown: Roundabout Gesso Motif // Design & Image: GLAM Studio
Delicate parallel lines of dark dryline course through these white tiles collaborated on with Block Shop Textiles to evoke the tradition of block printing in backsplash form.
Ready to start your black and white backsplash design? Get in touch with our Design Consultants for free personalized design assistance including sampling, estimating, renderings and ordering.


text:
Try to look at the connection through your child's eyes. So what does your child read contained in this person? What's the destination? Understanding where she or he comes from is certainly going a long way in equipping you with the understanding and concern you'll need.
If you this, you will end up less likely to state things like "I never preferred him anyhow," or "I know she ended up being no-good" when your teenager experiences a harsh area or needs to speak about an issue when you look at the partnership. While you can be appropriate, you won't want to emphasize that. Its alot more effective and better for the commitment together with your son or daughter for those who have a proper understanding of the initial destination and the control she or he might be experiencing if and when the relationship concludes.
Up to you may not fancy which your teen are internet dating, make sure to make sure you feel kind, polite, and approachable.
Recall, if you getting impolite and standoff-ish, you'll likely have the exact same treatment in return. [Read more…] about Try to find Excellent Qualities. Whenever parents remain their own teenagers in addition to their passionate lovers, it's important which they hold an unbarred mind.


text:
Search the Noteworthy Practices database
This case study presents an interchange alternatives analysis from the Indiana Department of Transportation (INDOT). The analysis supported a multi-agency planning and engineering effort that involved INDOT, the Indianapolis Metropolitan Planning Organization, Hamilton County, Town of Fishers, and City of Noblesville. These agencies identified State Road (SR) 37 from 126th Street in Fishers to SR 32/38 in Noblesville as a candidate for significant mobility and safety improvements. The SR 37 corridor project had two primary needs: 1) reduce existing and forecasted congestion at signalized intersections within the study area, and 2) reduce the crash frequency and rate at identified intersections. INDOT targeted five, at-grade signalized intersections along the study corridor for interchange improvements. The safety analysis applied State-specific safety performance functions (SPFs) and crash modification factors (CMFs) derived from the American Associate of State Highway and Transportation Officials (AASHTO) Highway Safety Manual (HSM) to predict crashes for "Build" and "No-Build" scenarios over a 20-year period between 2018 and 2038. The INDOT analysis encountered several key challenges, including key technical inputs for the Interactive Highway Safety Design Model (IHSDM) software and the application of the HSM to future design alternatives; for instance, INDOT did not apply the Empirical-Bayes (EB) method due to the significant change in the design and operational performance of the corridor between the Build and No-Build scenarios. INDOT's ingenuity and engineering judgment allowed the agency to navigate many of these challenges, and the analysis predicted that the Build alternative, although originally proposed for its traffic operational improvements, should yield a safety benefit and reduce crashes compared to the No-Build alternative future.


text:
Have some new parents in your life? Give them the perfect Dino themed gift box. A special keepsake that will last a lifetime! This gift box comes ready for gifting packaged in a white box filled with crinkle paper and three special items! Send it directly to the recipient with a hand written gift note.
Each Box includes:
Please include the first and middle name in the notes box for the name disk.
You can choose to personalize the Brontosaurus Grasping Toy and/or the Triceratops Rattle with a single word ($8) per toy (unfortunately, two word engraving and birth stats are not available on these items) or you can leave them plain.
Be sure to include your note for the recipient in the "Notes for Order" box, and sign your name! ;) (billing info does not show up!)
The items in the Dino gift box are not available separate from the box set.
Playfulbabies Toys has been handcrafting heirloom quality modern wood toys in the heart of Iowa since 2011. Each toy is created with the intention of letting imagination and creativity thrive in children.
Do not use without full supervision. Inspect toys before every use and discard if damaged or beads come loose.


text:
* Silver Zinc and Silver Powder Coat Finish
* 4130 Chrome Moly Seamless Tubing (Lower Control Arms)
* Manufactured from Indestructible Heat Treated Steel
* Grade 8 Hardware for Upper and Lower Control Arms
* Larger Heim Joints and Heat Treated Steel Bushing Sleeves (Upper and Lower Control Arms)
* Upper and Lower Control Arms fully Tig Welded in Billet Steel Fixtures
1. Chrome Moly Adjustable Extreme Race Lower Control Arms
2. Chrome Moly Double Adjustable Extreme Race Upper Control Arms
3. Double Anti-Roll Bar with roller bearings*
4. 7075 Billet Spherical housing bushing kit
Quality Construction:
Lower control arms feature 4130 Chrome Moly .083 wall thickness seamless tubing CNC machined and tig welded in Billet Steel Fixtures for a perfect fit every time. 7075 billet aluminum bushings and high strength performance alloy rod ends.
Upper control arms feature Chrome Moly Formed boxes that have been revised with a gusset to eliminate any flex or unwanted distortion from Ultra High Horsepower Mustangs. The 4130 Chrome-Moly threaded adjuster system allows these bars to be fully in car adjustable on the fly or between rounds in the lanes.
Setting your pinion angle just got so much easier that it can be done in just minutes.
All parts are Fully CNC machined and Tig welded in billet steel fixtures to ensure a perfect fit.
Our Silver Zinc Plating will withstand the Elements & Resistant Corrosion.
Last but not least both upper and lower control arms have all grade 8 hardware, heat treated steel bushings sleeves and oversized heavy duty heim joints.
*Anti-Roll bar will NOT work with stock tailpipes!
Fits these Vehicles:
1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 LX GT GTS Mustang Cobra* Shelby Roush Saleen & Steeda Vehicles.


text:
Prep: 20 minutes
Cook: 35 minutes • Serves: 8
1 tablespoon PICS olive oil
3 garlic cloves, minced
1 medium carrot, finely chopped
1/2 cup finely chopped bell pepper
1/2 cup finely chopped white onion
1/2 (28-ounce) can PICS diced tomatoes
1/4 cup PICS ketchup
2 tablespoons PICS Dijon mustard
2 teaspoons PICS chili powder
1/4 teaspoon PICS salt
1/4 teaspoon PICS black pepper
8 whole wheat hamburger buns, split
1.Prepare lentils as label directs.
2. In large skillet, heat oil over medium heat. Add garlic, carrot, bell pepper and onion; cook 5 minutes or until tender, stirring frequently. Add tomatoes with their juice, ketchup, mustard, chili powder, lentils, 1/2 cup water, salt and black pepper; cook 10 minutes or until slightly thickened, stirring occasionally. Makes about 5 cups.
3. Toast buns; serve filled with lentil mixture.
Approximate nutritional values per serving (1 sandwich):
300 Calories, 5g Fat, 1g Saturated Fat, 0mg Cholesterol, 569mg Sodium,
50g Carbohydrates, 9g Fiber, 8g Sugars, 5g Added Sugars, 15g Protein
Chef Tip:
Use leftover lentil mixture as a hearty pasta sauce, add to soup or stew, or serve over whole grain toast topped with a poached egg.


text:
Charcuterie Board Catering in Los Angeles
In need of charcuterie board catering in Los Angeles? Take a look at the range of charcuterie board catering options we offer throughout Los Angeles and Southern California below! We provide charcuterie board catering to any city within Southern California all the way down to San Diego, including but not limited to Los Angeles, Palm Springs, Orange County, Burbank, Glendale, Pasadena, and Riverside. Our team of artists are here to create eye-catching charcuterie board designs for your next occasion!
Charcuterie Board Designs
Exquisite Los Angeles Charcuterie Board Catering
Our Los Angeles charcuterie board catering services are included in all of our catering packages that you book! When you work with us for food catering for any of your events, we can incorporate luxury charcuterie boards and themed charcuterie board designs as part of your appetizer displays. We offer everything from grazing tables to individually sized miniature charcuterie boards.
Gourmet Charcuterie Board Designs
Charcuterie Board Catering With Premium Ingredients
As part of our quality commitment at Robert's Catering, we use only the best cheese, meat, fresh produce, and gourmet selections for our charcuterie board catering. Every ingredient used comes from local artisans that provide the best in their business, from organic and meaty Italian red olives to organic beet we use to create a signature beet hummus dip featured on some of our charcuterie board designs. We source our meat and cheese selections from local producers who use only natural ingredients, offering a wide selection of cheeses and specialty international cold cuts to select from.
Charcuterie Board Design Artists
Artistic Charcuterie Board Designs
Charcuterie boards are a beautiful and delicious addition to any event or gathering you're having, and our artists are here to create one-of-a-kind designs that match the style, color scheme, and palette of your event! Our charcuterie board catering team can design a range of charcuterie boards for your needs, from classic meat and cheese boards to Mediterranean boards featuring add ons like freshly baked pita chips, marinated olives, and stuffed grape leaves. Our charcuterie board catering designs are hand-cut and plated to feature beautiful standout designs sure to impress your guests. From intricately cut shapes to florals and patterns created from our selections, our charcuterie board designs are as tasty to look at as they are to eat! Let our team know if you have a theme in mind for your event, and we can create colorful charcuterie board designs to match!
International Cheese, Herb, and Charcuterie Displays
Herb and Cheese Displays
In addition to charcuterie board catering, we're known for creating intricate cheese boards and displays featuring fresh herbs, garnishes such as our homemade crostinis, marinated artichoke hearts, and more. We're happy to create boards featuring regional combinations and selections. For example, our Persian herb and cheese display includes fresh Persian dill, tarragon, mint, cilantro, basil, green onions, radishes, cucumbers, walnuts, feta, Cornelian cherry (zoghal akhte), yogurt shallot dip (mas moosir), and sangak bread.
Types of Charctuerie Board Designs We Offer
Seafood Charcuterie Board Selections
Seafood charcuterie board selections are a great way to elevate your table centerpieces and showcase a new charcuterie board style! Known as a seacuterie board, seafood charcuterie boards are just one of the many traditional charcuterie board variations we can create for you! Our seafood charcuterie boards feature fresh, wild-caught seafood selections ranging from king crab legs and smoked salmon to halibut, shrimp, fresh oysters, and more. Seacuterie boards are great to pair with a selection of pickled fresh product, artisan bread, and specialty in-house made crackers we can create. Our seafood charcuterie boards can be made to incorporate gluten free, keto, and low-carb ingredients for a healthy twist!
With seafood charcuterie boards, we can also incorporte a mix of hot and cold seafood selections, from crab cakes and rolls to grilled shrimp skewers, fresh shrimp coktails, grilled lobster tails and cooked muscles and more. We can also create custom seafood dips to go alone with your seacuterie board, from smoked salmon dip to crab and artichoke dips and more. Seacuterie boards can be made to fit any occasion, from a lobster BLT board to build your own BLTs to a seasonal fall or summer seacuterie board featuring the best in seasonal produce and seafood.
Grazing Tables
Grazing tables make the perfect appetizer for any event, featuring a stunning visual display of an array of cured meats, fresh produce, sweets, and more. While grazing tables are similar to charcuterie boards, featuring items commonly seen like gourmet cheeses, crackers and bread sticks, and fresh produce, the large scale surface of grazing tables allows for the incorporation of ingredients to suit every palate. Grazing tables often include a wider selection of sweet and salty combinations such as chocolates, mini pastries, candied nuts, pickled vegetables, and jams and jellies. Grazing tables can also incorporate a range of fresh produce that adds both vegetarian options and bright colors into the mix.
Whether you're looking to display a grazing table at your next party or as part of your wedding reception, our team can put together breathtaking grazing tables that match your color scheme and decor. We can incorporate elevated stands to display multi-level grazing tables, and bring in additional design elements that include fresh herbs, florals, greenery beds, and even miniature signage to showcase each ingredient on display. Our connection to local producers allows us to source the freshest seafood, meat, and gourmet cheese selections for display, as well as vivid hues of vegetables from natural violets to cherry reds.
Individual Charcuterie Boxes, Boards and Cups
Individual charcuterie boards and individual charcuterie boxes are a fun and personalized way to offer charcuterie board designs to your guests in a compact and easy-to-hold manner! Our individual charcuterie boxes and individual charcuterie cups feature the same beloved ingredients typically found in large-scale charcuterie boards, from dried fruits and nuts to fresh herbs, cured meats, and specialty cheese, but in a smaller format. We can create custom individual charcuterie boxes and boards with your guest's names and preferences, in addition to fun cups that can include playful touches like fruit skewers, colorful pickles, and more.
Large Charcuterie Boards
We can create large charcuterie boards suited for hundreds of guests. Our Instagram-worthy charcuterie board designs can feature themed colors for your event, from vivid pinks and reds to neutrals and more, with the ability to curate a wide selection of specialty meats and cheeses. For example, if you're looking to feature a charcuterie board with Persian and Armenian cheese, we can create custom boards incorporating fresh Persian herbs, pickles, cheese, and more. We work with some of the best local producers in California, providing a large range of rare premium offerings including crisp dried fruits, naturally-smoked meats, and more.
Charcuterie Board Designs Catering For Any Dietary Needs
Custom creating menus suited for each of our clients is always our top priority. That's why we make it a point to accommodate any dietary restrictions you or your guests may have. While our facility is not a dedicated facility free of these allergens, our staff will take the utmost care when preparing dishes for your specific needs.
Dairy Free Catering
Gluten Free Catering
Vegetarian and Vegan
Kosher Catering
Nut Free Catering
Halal Catering
Catering Services
Our Catering Services
Wedding Catering
Occasions Catering
Corporate Catering
Banquet Halls and Event Venues
Banquet Halls and Event Venues We Work With
Our catering is off-premise, meaning we can provide you with catering at any facility that allows outside caterers! In addition, we have a range of venues we work with in California as a preferred and exclusive catering venue. Take a look at just some of the locations our catering is currently in, and contact us to chat about other venues you may have in mind!
Award-Winning Catering Since 1960
About Robert's Catering Service
Robert's Catering Service is a full service catering that has been in the business for over 60 years. We provide not only exceptional food, but exceptional staff for your event as well!


text:
SANTECO Molle Thermal Carafe, 40 oz, Stainless Steel, Vacuum Insulated
Guaranteed Safe Checkout:
Need a carafe that is insulated, stylish, lightweight, and sealed?
Meet the SANTECO Molle, a vacuum-insulated carafe with excellent temperature retention, perfect for lugging around that icy lemonade or steaming hot tea.
Our patented 360 lid is easy to use, leak-resistant, and easy to disassemble for thorough cleaning. Unscrew the lid, and you'll find a wide mouth that makes it easy to add ice or clean.
· Please wash carafe with mild detergent and rinse thoroughly before use.
· Do not place carafe in the microwave or freezer.
· Keep out of reach of children when filled with hot liquids.
· Do not filled with carbonated drinks, leaks may occur.
· Please consume perishable drinks timely and clean the carafe promptly.
· Please avoid violent impacts and drops for longer product life.
· For optimal performance, pre-heat or pre-cool inside of carafe before use.
· Top rack dishwasher safe.
Product name: Molle Thermal Carafe
Capacity: 40 oz, 1200 mL
Materials: Stainless steel body with polypropylene lid
Insulation: Vacuum insulated
Dishwasher safe: Yes
Safe with carbonated drinks: No
Dimensions (cm, in): 10.2×10.2×25.4, 4.02×4.02×10
Weight: 503.5 g, 1.11 lb
Considerate Design
· 360 Lid is easy to use & can be disassembled for cleaning.
· Wide mouth for easy filling and cleaning.
· Double-wall vacuum insulated for max thermal retention.
· Ideal for hot & cold drinks both indoors and outdoors.
· Safe to touch with hot drinks, won't sweat with cold drinks.
· Powder coat and brushed steel stand up to wear and tear.
· Food grade 18/8 stainless steel body with BPA-free parts.
· Top rack dishwasher safe.
360 Lid
Our patented 360 lid is easy to use and leak-resistant. Tilt the 360 button by pressing on its edge to open the lid for pouring and pop it back upright to reseal. Disassembly is straightforward to facilitate thorough cleaning.
Powder Coat
The delightfully grippy surface texture is a result of our powder coating. Powder coating is far more environmentally friendly than conventional paint and much more durable too.
18/8 Stainless
18/8 stainless steel, a.k.a. 304 stainless steel, has been a mainstay material of the food industry for many years. We use it in our bottles for its excellent corrosion resistance, durability, and workability.
Vacuum Insulation
We vacuumize our double-wall thermal bottles for maximum thermal retention. Our vacuum layer is made as thin as possible to reduce weight without a reduction in effectiveness. Difficult to get right, but worth the effort.


text:
Keanu Reeves is a renowned actor, musician, and philanthropist best known for his iconic roles in films such as The Matrix and John Wick. Although he has primarily made his fortune in Hollywood, he has also found success in the music industry. In fact, Reeves has used his involvement in the music industry to significantly increase his net worth theviralnewj. In 2009, Reeves launched his own record label, Side One Dummy Records, in partnership with the Los Angeles-based music label, Side One. The label was an instant success, producing several albums of various genres. Through his record label, Reeves has signed and promoted many up-and-coming artists, helping to put them on the map. Not only has this enabled him to generate income from record sales, but also to be credited for his work in the music industry Net Worth. In addition, Reeves has also been involved in various music-related projects. For example, he has collaborated with world-renowned musicians such as Dave Grohl, the lead singer of the Foo Fighters, and singer-songwriter, Ed Sheeran. He has also featured in the music videos of newsintv several artists, including My Chemical Romance and Avril Lavigne. Moreover, Reeves has also launched his own YouTube channel, which he uses to showcase his musical talents. On his channel, Reeves has uploaded several of his own songs, as well as covers of popular songs. This has enabled him to reach a wider audience and to increase his personal brand. Overall, it is clear that Reeves has used his involvement in the music industry to his advantage, helping him to significantly increase his net worth. In addition, he has been able to use his music to reach a wider audience and to further promote his brand Bio Data.
His generosity has enabled him to increase his net worth in the form of goodwill and public recognition. Overall, Keanu Reeves has used his acting talents to increase his net worth significantly. Through his smart investments, philanthropy, and successful film projects, he has become one of Hollywood's most successful and recognizable actors Bio Data famousbiography.


text:
- Research
- Open access
- Published:
One-year follow-up study after patients with severe COVID-19 received human umbilical cord mesenchymal stem cells treatment
Stem Cell Research & Therapy volume 13, Article number: 321 (2022)
The novel coronavirus is still mutating, and the pandemic continues. Meanwhile, many COVID-19 survivors have residual postinfection clinical manifestations. Human umbilical cord mesenchymal stem cells (hUC-MSCs) have been shown to be effective in the early stages of COVID-19.
The aim of this study was to investigate long-term safety and efficacy of treatment in patients with severe COVID-19 patients who had received hUC-MSCs therapy.
Twenty-five discharged patients who had severe COVID-19 (including the standard treatment group and the standard treatment plus hUC-MSCs group) were enrolled in a 1-year follow-up. The assessment considered adverse effects (including effects on liver and kidney function, coagulation, ECG, tumor marker, and so on), pulmonary function, St George's Respiratory Questionnaire (SGRQ), postinfection sequelae and serum concentration of Krebs von den Lungen-6 (KL-6), malondialdehyde (MDA), H2S, carnitine, and N-6 long-chain polyunsaturated fatty acids (N-6 LC-PUFAs).
Measurements and main results
Pulmonary ventilation function had significantly improved at the 1-year follow-up in both the hUC-MSCs group and the control group compared with the 3-month follow-up (P < 0.01). Fatigue (60% [15/25]) remained the most common symptom at the 1-year follow-up. The rate of fatigue relief was significantly reduced in the hUC-MSCs group (25% [2/8]) compared to the control group (76.5% [13/17]) (P = 0.028). The level of KL-6 was significantly lower in the hUC-MSCs group (2585.5 ± 186.5 U/ml) than in the control group (3120.7 ± 158.3 U/ml) (P < 0.001). Compared with the control group, the hUC-MSCs group had a lower level of MDA (9.27 ± 0.54 vs. 9.91 ± 0.72 nmol/ml, P = 0.036). No obvious adverse effects were observed in the hUC-MSCs treatment group at 1 year after discharge.
Intravenous transplantation of hUC-MSCs was a safe approach in the long term in the treatment of patients with severe COVID-19. In addition, hUC-MSCs had a positive effect on postinfection sequelae in COVID-19 survivors.
Trial registration
Chinese Clinical Trial Registration; ChiCTR2000031494; Registered 02 April 2020—Retrospectively registered, http://www.medresman.org
Coronavirus disease 2019 (COVID-19), which is caused by the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), developed rapidly into a global epidemics [1]. As of January 2022, more than 271.9 million confirmed cases of COVID-19, including 5.3 million deaths, have been reported to the WHO [2]. Several studies have reported that COVID-19 patients still have many postinfection clinical manifestations 1 year after discharge from the hospital, including dyspnea, fatigue, anxiety, impaired pulmonary function, chest CT abnormalities, and so on [3,4,5].
In a study of the SARS-CoV-2 Omicron variant in Denman, compared with Delta variant cases, the Omicron variant led to a higher rate of ICU admission (0.13% vs. 0.11%) [6]. At present, due to the limited efficacy of various antiviral agents in the short-term treatment of severe COVID-19 cases, the main treatment principles are still symptomatic and supportive therapy [7]. Then, an improvement in long-term sequelae is even less clear. An excessive inflammatory response is an important mechanism of disease aggravation and even death in patients with COVID-19 [8], and cytokine storms are closely related to clinical outcome in COVID-19 patients in the early stage of disease [9].
Many studies have shown that stem cells have immune modulation, tissue repair, and differentiation properties in infectious diseases [10,11,12]. In our previous study, we demonstrated the early-stage safety and preliminary therapeutic effect of hUC-MSCs in patients with severe COVID-19 [13, 14]. To date, there have been no 1-year follow-up studies on the safety and efficacy of stem cells therapy in severe COVID-19. The aim of this study was to further observe the long-term safety and improvement in sequelae of severe COVID-19 patients treated with hUC-MSCs.
Study design and participants
This was a longitudinal cohort study of patients with severe COVID-19 who were discharged from Huangshi Hospital of Traditional Chinese Medicine in Hubei Province from February 12 to March 25, 2020. The diagnosis criteria for severe COVID-19 followed a new coronavirus pneumonia diagnosis and treatment program (5th ed.) (in Chinese) [15]. The patients were randomly divided into 2 groups: a standard treatment group (control group) and a standard treatment plus human umbilical cord mesenchymal stem cells infusion group (hUC-MSCs group). In general, participation in this study was recommended for patients with severe COVID-19 cases whose clinical symptoms had not improved significantly after 7 to 10 days of standard treatment. The standard treatment was as follows: (1) supplemental oxygen (noninvasive or invasive ventilation); (2) antiviral agents (abidor/oseltamivir); (3) antibiotic agents (oral moxifloxacin or select antibiotics according to drug sensitivity tests); and (4) glucocorticoid therapy (1–2 mg/kg, less than a week).
The 1-year follow-up study was conducted from March 20 to April 14, 2021. This study enrolled 25 patients from our previously studied cohort who had been discharged 1 year ago (382–390 days) from Huangshi Hospital of Traditional Chinese Medicine in Hubei Province, China. The exclusion criteria included refusal to participate or loss of contact. None of the enrolled patients had been reinfected with SARS-CoV-2 in the past 1 year and developed other infectious diseases for nearly 2 weeks. The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Huangshi Hospital of Traditional Chinese Medicine (No. HSZYPJ-2020-009-01). Written informed consent was obtained from all patients or their representatives who attended the follow-up visit.
Cell preparation and transplantation
Clinical-grade hUC-MSCs were donated by the Jiangsu Cell Tech Medical Research Institute and Jiangsu Cell Tech Biotechnology Co of China. The product was registered at the China Clinical Trial Center (Registration No. ChiCTR2000031494). MSCs were prepared as previously described [13, 14]. Cells were cultured from the 2nd passage to the 3rd passage, which showed positive expression of CD73, CD90, and CD105 (> 95%) and negative expression of CD34, CD45, CD14 or CD11b, CD79α or CD19, and HLA-DR (< 2%) on the surface, as recommended by the International Society for Cellular Therapy (ISCT). The MSCs were suspended in 100 mL normal saline solution (0.9%), and the final number of transplanted cells was 2 × 106 cells/kg. The hUC-MSCs were administered intravenously at a speed of 35 drops/min for approximately 1 h.
Follow-up assessment
Eligible severe COVID-19 patients were invited to Huangshi Hospital of Traditional Chinese Medicine for two follow-up visits at 6 and 12 months after discharge. Follow-up procedures and indicators at 6 months are described in our previous studies [13, 14]. All patients were presented face to face with a series of questionnaires to assess their sequelae and quality of life. A self-reported symptom questionnaire was used to assess residual clinical symptoms 1 year later. The SGRQ was used to evaluate the impact of lung disease on patients' quality of life, and the questionnaire contained 50 items divided into three subgroups of symptoms, activities and effects [16]. Meanwhile, we performed a series of laboratory examinations to assess the patient's basic health status and adverse reactions, which included routine blood tests, biochemistry, blood gas, coagulation and SARS-COV-2 antibodies.
Pulmonary function testing was performed according to the standards of the American Thoracic Society, which include vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC ratio, peak expiratory flow (PEF), and maximal voluntary ventilation (MVV). Salbutamol (a prebronchodilator) at 400 mg was administered during pulmonary function tests. Pulmonary function parameter results are shown as a percentage of the predicted value [17].
We tested the levels of plasma KL-6, MDA, H2S, carnitine, and N-6 LC-PUFA in all patients using ELISA kits. KL-6 is an important indicator for detecting pulmonary fibrosis, and MDA, H2S, carnitine, and N-6 LC-PUFA are key mediators that lead to fatigue symptoms with different mechanisms in patients.
Outcome measures
The primary outcomes were adverse effects of MSCs therapy and long-term sequelae in patients with severe COVID-19. The secondary outcomes were SGRQ score, pulmonary function, and the levels of plasma KL-6, MDA, H2S, carnitine, and N-6 LC-PUFA in patients with severe COVID-19.
Statistical analysis
All statistical analyses were performed with SPSS 21.0 software. Continuous variables were described using mean (± SD) or median (interquartile range, IQR) values, depending on whether they were normally distributed. Categorical variables were described as percentages. Continuous variables were compared using independent samples and related samples t tests, and categorical variables were compared using a X2 test. All statistical tests were two tailed, and a P value less than 0.05 was considered statistically significant.
Follow-up procedure and baseline characteristics
From February 12, 2020, to March 25, 2020, a total of 41 patients with severe COVID-19 were enrolled in this study, including 12 participants in the hUC-MSCs treatment group and 29 in the control group. At the 3-month follow-up, 7 cases were excluded (3 deaths occurred in the hospital and 4 cases could not be contacted), 5 cases refused follow-up, and 1 case was excluded from the study due to severe COPD. At the 1-year follow-up, 2 cases could not be contacted, and 1 case refused follow-up. Our final numbers included 8 cases enrolled in the hUC-MSCs treatment group and 17 cases in the control group (Fig. 1).
Table 1 shows the demographic characteristics and laboratory tests results for the 25 follow-up patients. The median age (interquartile range, IQR) was 51.00 (45.00, 67.00) years, with 50.50 (39.00, 72.75) years for the hUC-MSCs group and 52.00 (45.00, 63.00) years for the control group (P = 0.521). Forty-four percent (11/25) of patients were male (50.0% in the hUC-MSCs group vs. 41.18% in the control group, P = 1.000), and 28% (7/25) of patients smoked, including 37.5% (3/8) in the hUC-MSCs group and 23.53% (4/17) in the control group (P = 0.640). The BMIs in the hUC-MSCs treatment group and control group were 22.91 (20.40, 24.43) and 26.08 (21.51, 27.99), respectively (P = 0.181). Forty percent (10/25) of patients had comorbidities, including diabetes, hypertension, and other underlying diseases (50% in the hUC-MSCs treatment group vs. 35.29% in the control group, P = 0.667). In general, there were no significant differences in age, sex, smoking status, BMI, or comorbidities between the two groups.
Primary outcomes
One year after hUC-MSCs treatment, none of the patients showed abnormalities in liver function, routine blood tests, or ECGs. None of the patients developed significant skin pigmentation, blurred vision, neuropsychiatric abnormalities, or other serious complications. Two discharged patients had slightly elevated NSE and CA12-5, and one patient had a mild increase in creatinine (Table 2).
At the 3-month follow-up, the most common symptoms (> 50%) were shortness of breath (76% [19/25]), fatigue (68% [17/25]), and sleep disorders (64% [16/25]). Fatigue (60% [15/25]) remained the most common symptom at the 1-year follow-up, whereas the rate of fatigue relief was significantly reduced in the hUC-MSCs group (25% [2/8]) compared to the control group (76.5% [13/17]) (P = 0.028). The proportion of patients with shortness of breath fell from 76% (19/25) at 3 months to 28% (7/25) at 1 year (P = 0.002), which also occurred in the hUC-MSCs treatment group (75% [6/8] vs. 12.5% [1/8], P = 0.041) and the control group (76.5% [13/17] vs. 35.3% [6/17], P = 0.037).
Secondary outcomes
The SGRQ score decreased from 26.76 ± 11.34 at 3 months to 12.32 ± 8.88 at 1 year (P < 0.001) in both the hUC-MSCs treatment group (15.2 ± 3.69 vs. 9.13 ± 7.47, P = 0.012) and the control group (32.18 ± 9.46 vs. 13.82 ± 9.29, P < 0.001) (Table 3). The results of pulmonary function testing are shown in Table 4. Compared with the control group, there were no significant differences in the hUC-MSCs treatment group in terms of indicators of pulmonary function, including VC (% of predicted), FVC (% of predicted), FEV1 (% of predicted), FEV1/FVC, PEF (% of predicted), and MVV (% of predicted), at the 1-year follow-up. However, the above indicators significantly improved at the 1-year follow-up in both the hUC-MSCs group and the control group compared with 3 months after discharge. The level of KL-6 was significantly lower in the hUC-MSCs group (2585.5 ± 186.5 U/ml) than in the control group (3120.7 ± 158.3 U/ml) (P < 0.001). Compared with the control group, the hUC-MSCs group had a lower level of MDA (9.27 ± 0.54 vs. 9.91 ± 0.72 nmol/ml, P = 0.036) and a higher level of N-6 LC-PUFAs (200.1 ± 11.6 vs. 209.1 ± 11.3 pg/ml, P = 0.083). There were no significant differences in the levels of H2S and carnitine.
Despite efforts to strengthen vaccination, quarantine policies, and restrictions on social distancing, the number of confirmed cases and deaths of COVID-19 patients around the world continues to rise rapidly [2]. In addition, patients with severe COVID-19 often develop ARDS, and the prognosis is frequently poor [18, 19]. Several studies have shown that nearly half of COVID-19 survivors still have at least one clinical sequelae at the 1-year follow-up [3, 5].
Currently, there are several methods to treat severe COVID-19 patients, such as MSCs-based therapy, convalescent plasma, antiviral drugs, Chinese traditional medicine, and so on. In a series of our previous studies and in many other reports, we demonstrated the safety and short-term efficacy of stem cells therapy. In the acute phase of COVID-19, hUC-MSCs may inhibit an excessive inflammatory response through their immunomodulatory properties. In the convalescence phase, MSCs may participate in the tissue repair of alveolar epithelial cells through their strong differentiation abilities [13, 14, 20,21,22]. However, the long-term efficacy and safety of stem cells in the treatment of COVID-19 are still unclear. To our knowledge, there have been no 1-year follow-up studies for COVID-19 patients who received stem cells therapy.
Based on previous studies on the safety and initial efficacy of stem cells in the treatment of COVID-19, we conducted a 1-year follow-up study to explore the long-term safety and efficacy of stem cells. Twenty-five patients, including a control group and an hUC-MSCs treatment group, had almost normal ranges in terms of routine blood tests, liver and kidney function, coagulation, myocardial injury, and inflammatory markers. Meanwhile, the above indicators were not significantly different between the two groups. In previous short-term follow-up studies, no serious adverse events were observed after 1–3 months of stem cells therapy in patients with COVID-19 [20, 22, 23]. In addition, a 5-year follow-up study of stem cells treatment for H7N9 did not reveal any adverse effects [24]. In this study, we observed a slight elevation in tumor markers, including CA12-5 and NSE, in patients 2 and 5, respectively. Patient 2 already had a mild elevation of CA12-5 at the 3-month follow-up and continued to show a similar elevation of CA12-5 at the 1-year follow-up. Although a slight NSE elevation was found in patient 5, we did not detect any evidence of tumors. Patient 7 had a mild increase in creatinine from 72 to 83 (normal < 80) over 9 months. In addition, no adverse effects, such as significant skin pigmentation, blurred vision, or neuropsychiatric abnormalities, were observed in any patients, which confirmed the safety of hUC-MSCs therapy for COVID-19 at the 1-year follow-up.
In our study, we found that almost none of patients had obvious lesions or fibrous band shadows at 1-year follow-up (Additional file 1: Figure S1). Unfortunately, because some patients refused chest CT examination, we only analyzed the chest CT images of 17 of the 25 patients (7 in the MSCs group and 10 in the control group). Meanwhile, we found that pulmonary ventilation parameters in the vast majority of patients with severe COVID-19 were within the normal range at the 1-year follow-up, which was similar to other 1-year follow-up studies [3, 25]. We also found significant improvement in pulmonary function indicators at the 1-year follow-up compared with the 3-month follow-up, such as VC (% of predicted), FVC (% of predicted), FEV1 (% of predicted), FEV1/FVC, PEF (% of predicted), and MVV (% of predicted), which showed that pulmonary ventilation function in most severe COVID-19 patients had basically returned to normal by 1 year after discharge. In this regard, there were no significant differences in pulmonary ventilation function between the hUC-MSCs group and the control group at the 1-year follow-up. However, in the preceding series of 1-year follow-up studies, patients with severe COVID-19 had varying degrees of impairment in lung diffusion function, ranging from 31 to 38% [3, 25]. Follow-up studies of SARS have also shown that lung diffusion function impairment can last for months or even years [26,27,28]. Unfortunately, due to the limited conditions of primary hospitals, we were unable to conduct pulmonary diffusion function tests. KL-6, a predictive marker of interstitial lung disease, reflects the extent of damage to alveolar type II epithelial cells [29, 30], which has also been proven to be effective in predicting the prognosis of COVID-19 patients [31, 32]. Zeng et al. conducted a study on the proteomics of bronchoalveolar lavage fluid and showed a significant decrease in KL-6 in the lavage fluid of patients with severe COVID-19 compared with non-COVID-19 patients [33]. Our study found that KL-6 in the hUC-MSCs group was significantly lower than in the control group (2585.53 ± 186.45 vs. 3120.69 ± 158.34, P < 0.001) (Fig. 2A), indicating that hUC-MSCs may improve lung diffusion function by promoting alveolar epithelial cell regeneration.
In our previous study, we found that shortness of breath was the most common symptom of patients with severe COVID-19 at 3 months after discharge (Table 4). However, the most common sequelae shifted to fatigue at the 1-year follow-up, similar to other follow-up studies [3, 25, 34]. Lam MH et al. also showed that fatigue was the most common sequelae in SARS patients, even lasting for up to 4 years [35]. Interestingly, the rate of fatigue in the hUC-MSCs group was significantly lower than that in the control group (25.0% vs. 76.5%, P = 0.028). The causes and mechanisms of fatigue in COVID-19 survivors are unclear but based on previous studies of patients with chronic fatigue, causes may include lung diffusion function, redox imbalance, and impaired mitochondrial function [36,37,38,39]. Hence, we assessed MDA, H2S, carnitine, and N-6 LC-PUFAs, representing lipid peroxidation, protein sulfhydration, mitochondrial function, and the function of cell membranes, respectively [36,37,38,39,40,41]. We found that the levels of MDA significantly decreased in the hUC-MSCs group compared with the control group. MDA is a metabolite product when oxygen free radicals attack fatty acids on the cell membrane, directly reflecting the degree of lipid peroxidation. There was a direct positive correlation between MDA levels and fatigue symptoms [42]. Moreover, stem cells can reduce MDA production by regulating oxygen free radicals and inflammation [43, 44]. Therefore, we speculated that hUC-MSCs reduced MDA production by regulating oxidative stress, thereby improving fatigue symptoms in COVID-19 patients. At the same time, we detected a high level of N-6 LC-PUFAs in the hUC-MSCs group, although there was no significant difference, which may be due to an insufficient sample size. Viral infection may impair the biosynthesis of N-6 long-chain polyunsaturated fatty acids by inhibiting δ-6 desaturation of the essential fatty acids, thereby impairing cell membrane function and leading to fatigue symptoms [40]. In general, hUC-MSCs may alleviate fatigue in COVID-19 patients in a variety of ways, and further research is needed.
Our study has several limitations. First, this is a single-center and small-sample longitudinal cohort study, so systemic bias is inevitable. Second, due to a lack of equipment at the primary hospital, lung diffusion function testing was not performed. Third, this is a preliminary study on stem cells therapy for severe COVID-19, and the specific mechanism still needs further research.
In our 1-year follow-up, hUC-MSCs therapy remained a safe and effective means to combat severe COVID-19 infection. In addition, hUC-MSCs significantly alleviated fatigue symptoms in COVID-19 patients, possibly by reducing MDA production.
Availability of data and materials
The datasets used and/or analyzed in this study are available from the corresponding author upon reasonable request.
Coronavirus disease 2019
- hUC-MSCs:
Human umbilical cord mesenchymal stem cells
St George's Respiratory Questionnaire
C-reactive protein
Interquartile range
Creatine kinase
Lactate dehydrogenase
Alanine aminotransferase
Aspartate aminotransferase
Vital capacity
Vital capacity
Forced expiratory volume in 1s
Peak expiratory flow
Maximal voluntary ventilation
- N-6 LC-PUFAs:
N-6 long-chain polyunsaturated fatty acids
Krebs von den Lungen-6
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China Lancet. 2020;395:497–506.
WHO. Coronavirus disease (COVID-2019) situation reports. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports.
Huang L, Yao Q, Gu X, Wang Q, Ren L, Wang Y, et al. 1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study. Lancet. 2021;398:747–58.
Zhou F, Tao M, Shang L, Liu Y, Pan G, Jin Y, et al. Assessment of sequelae of COVID-19 nearly 1 year after diagnosis. Front Med (Lausanne). 2021;8: 717194.
Zhang X, Wang F, Shen Y, Zhang X, Cen Y, Wang B, et al. Symptoms and health outcomes among survivors of COVID-19 infection 1 year after discharge from hospitals in Wuhan, China. JAMA Netw Open. 2021;4: e2127403.
Espenhain L, Funk T, Overvad M, Edslev SM, Fonager J, Ingham AC, et al. Epidemiological characterisation of the first 785 SARS-CoV-2 Omicron variant cases in Denmark, December 2021. Euro Surveill. 2021;26:2101146.
Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. 2020;323:2052–9.
Kox M, Waalders N, Kooistra EJ, Gerretsen J, Pickkers P. Cytokine levels in critically ill patients with COVID-19 and other conditions. JAMA. 2020;324(15):1565–7.
Del VD, Kim-Schulze S, Huang HH, Beckmann ND, Nirenberg S, Wang B, et al. An inflammatory cytokine signature predicts COVID-19 severity and survival. Nat Med. 2020;26:1636–43.
Galipeau J, Sensebe L. Mesenchymal stromal cells: clinical challenges and therapeutic opportunities. Cell Stem Cell. 2018;22:824–33.
Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, et al. Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo. Proc Natl Acad Sci U S A. 2016;113:3621–6.
Jagiello J, Sekula-Stryjewska M, Noga S, Adamczyk E, Dzwigonska M, Kurcz M, et al. Impact of graphene-based surfaces on the basic biological properties of human umbilical cord mesenchymal stem cells: implications for ex vivo cell expansion aimed at tissue repair. Int J Mol Sci. 2019;20:4561.
Shu L, Niu C, Li R, Huang T, Wang Y, Huang M, et al. Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells. Stem Cell Res Ther. 2020;11:361.
Feng G, Shi L, Huang T, Ji N, Zheng Y, Lin H, et al. Human umbilical cord mesenchymal stromal cell treatment of severe COVID-19 patients: a 3-month follow-up study following hospital discharge. Stem Cells Dev. 2021;30:773–81.
Diagnosis and treatment program of pneumonia in novel Coronavirus infection (5th edn.). http://www.nhc.gov.cn/xcs/zhengcwj/202002/3b09b894ac9b4204a79db5b8912d4440.shtml. (in Chinese).
Jones PW, Quirk FH, Baveystock CM. The St George's Respiratory Questionnaire. Respir Med. 1991;85(Suppl B):25–31.
Standardization of spirometry, 1994 update. American Thoracic Society. Am J Respir Crit Care Med. 1995;152:1107–36.
Berlin DA, Gulick RM, Martinez FJ. Severe Covid-19. N Engl J Med. 2020;383:2451–60.
Matthay MA, Leligdowicz A, Liu KD. Biological mechanisms of COVID-19 acute respiratory distress syndrome. Am J Respir Crit Care Med. 2020;202:1489–91.
Lanzoni G, Linetsky E, Correa D, Messinger CS, Alvarez RA, Kouroupis D, et al. Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: a double-blind, phase 1/2a, randomized controlled trial. Stem Cells Transl Med. 2021;10:660–73.
Hashemian SR, Aliannejad R, Zarrabi M, Soleimani M, Vosough M, Hosseini SE, et al. Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series. Stem Cell Res Ther. 2021;12:91.
Xu X, Jiang W, Chen L, Xu Z, Zhang Q, Zhu M, et al. Evaluation of the safety and efficacy of using human menstrual blood-derived mesenchymal stromal cells in treating severe and critically ill COVID-19 patients: an exploratory clinical trial. Clin Transl Med. 2021;11: e297.
Shi L, Huang H, Lu X, Yan X, Jiang X, Xu R, et al. Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial. Signal Transduct Target Ther. 2021;6:58.
Chen J, Hu C, Chen L, Tang L, Zhu Y, Xu X, et al. Clinical study of mesenchymal stem cell treatment for acute respiratory distress syndrome induced by epidemic influenza A (H7N9) infection: a hint for COVID-19 treatment. Engineering (Beijing). 2020;6:1153–61.
Zhan Y, Zhu Y, Wang S, Jia S, Gao Y, Lu Y, et al. SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection. Signal Transduct Target Ther. 2021;6:368.
Hui DS, Wong KT, Ko FW, Tam LS, Chan DP, Woo J, et al. The 1-year impact of severe acute respiratory syndrome on pulmonary function, exercise capacity, and quality of life in a cohort of survivors. Chest. 2005;128:2247–61.
Hui DS, Joynt GM, Wong KT, Gomersall CD, Li TS, Antonio G, et al. Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors. Thorax. 2005;60:401–9.
Tansey CM, Louie M, Loeb M, Gold WL, Muller MP, de Jager J, et al. One-year outcomes and health care utilization in survivors of severe acute respiratory syndrome. Arch Intern Med. 2007;167:1312–20.
Kawase S, Hattori N, Ishikawa N, Horimasu Y, Fujitaka K, Furonaka O, et al. Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease. Respir Res. 2011;12:97.
Lee JS, Lee EY, Ha YJ, Kang EH, Lee YJ, Song YW. Serum KL-6 levels reflect the severity of interstitial lung disease associated with connective tissue disease. Arthritis Res Ther. 2019;21:58.
D'Alessandro M, Cameli P, Refini RM, Bergantini L, Alonzi V, Lanzarone N, et al. Serum KL-6 concentrations as a novel biomarker of severe COVID-19. J Med Virol. 2020;92:2216–20.
Deng K, Fan Q, Yang Y, Deng X, He R, Tan Y, et al. Prognostic roles of KL-6 in disease severity and lung injury in COVID-19 patients: a longitudinal retrospective analysis. J Med Virol. 2021;93:2505–12.
Zeng HL, Chen D, Yan J, Yang Q, Han QQ, Li SS, et al. Proteomic characteristics of bronchoalveolar lavage fluid in critical COVID-19 patients. Febs J. 2021;288:5190–200.
Fernandez-de-Las-Penas C, Guijarro C, Plaza-Canteli S, Hernandez-Barrera V, Torres-Macho J. Prevalence of Post-COVID-19 cough one year after SARS-CoV-2 infection: a multicenter study. Lung. 2021;199:249–53.
Lam MH, Wing YK, Yu MW, Leung CM, Ma RC, Kong AP, et al. Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up. Arch Intern Med. 2009;169:2142–7.
Paul BD, Lemle MD, Komaroff AL, Snyder SH. Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome. Proc Natl Acad Sci USA. 2021;118:e2024358118.
Tomas C, Newton J. Metabolic abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a mini-review. Biochem Soc Trans. 2018;46:547–53.
Lombardi VC, Ruscetti FW, Das GJ, Pfost MA, Hagen KS, Peterson DL, et al. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science. 2009;326:585–9.
Ngai JC, Ko FW, Ng SS, To KW, Tong M, Hui DS. The long-term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status. Respirology. 2010;15:543–50.
Puri BK. Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). J Clin Pathol. 2007;60:122–4.
Paul BD, Snyder SH. H(2)S signalling through protein sulfhydration and beyond. Nat Rev Mol Cell Biol. 2012;13:499–507.
Duruoz MT, Gezer HH, Nas K, Kilic E, Sargin B, Acer KS, et al. The impact of fatigue on patients with psoriatic arthritis: a multi-center study of the TLAR-network. Rheumatol Int. 2020;40:1803–15.
Shen Y, Jiang X, Meng L, Xia C, Zhang L, Xin Y. Transplantation of bone marrow mesenchymal stem cells prevents radiation-induced artery injury by suppressing oxidative stress and inflammation. Oxid Med Cell Longev. 2018;2018:5942916.
El-Metwaly S, El-Senduny FF, El-Demerdash RS, Abdel-Aziz AF. Mesenchymal stem cells alleviate hydrochloric acid-induced lung injury through suppression of inflammation, oxidative stress and apoptosis in comparison to moxifloxacin and sildenafil. Heliyon. 2019;5: e2710.
We thank all patients involved in the follow-up study.
This work was supported by grant from the National Natural Science Foundation of China (81870009, 82070017).
Author information
Authors and Affiliations
All authors have made substantial contributions to this study. L. Shi, YZ, ZC, and NJ contributed equally to this study. GF, L. Shi, YZ, NJ, and ZC were involved in design. YZ, L. Shu, XC, MW, KD, JW, XW, YC, and JY contributed to acquisition and extraction of data. L. Shi, XC, and CN were involved in analysis and interpretation of data. L. Shu and YW contributed to stem cells technology support. L. Shi, YZ, ZC, and NJ were involved in writing and editing. MH, TH, RL, and GF contributed to supervision. All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Ethics approval and consent to participate
This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Huangshi Hospital of Traditional Chinese Medicine (No. HSZYPJ-2020-009-01). Written informed consent was obtained from all patients or their representatives who attended the follow-up visit.
Consent for publication
Not applicable.
Competing interests
The authors declare that they have no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Additional file 1.
Almost none of patients had obvious lesions or fibrous band shadows at 1-year follow-up.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Shi, L., Zheng, Y., Cheng, Z. et al. One-year follow-up study after patients with severe COVID-19 received human umbilical cord mesenchymal stem cells treatment. Stem Cell Res Ther 13, 321 (2022). https://doi.org/10.1186/s13287-022-02972-3
DOI: https://doi.org/10.1186/s13287-022-02972-3


text:
Need Help on
Content Marketing ?
Read our case studies and contact us to listen to content marketing ideas.
Blog Writing Services
Content Inception's blog writing services are not just content writing and publishing activities to keep your site updated, but part of a marketing strategy. When the goal is to gain organic traffic, the marketing objective must define the roadmap rather than a set of mechanical activities.
Our blogging strategy is based on your industry type, focused services, and target audience. Keeping a close eye on the recent trends, such as new techniques, technology disruptions, software updates, or consumer requirements in your specific industry, CI plans your blog marketing.
The strategy needs to be full-proof and aligned to your end objective of getting a maximum relevant audience and maximum lead generation. So, as an extension of our SEO services, all the blogs that we write are optimized with appropriate keywords and substantiations. To learn more about our approach towards blogging, email us today.
SEO Optimized Blogging Services from Content Inception
After extensive research on your industry trends, our content team finalizes the blog topic to write. Depending on your content marketing plans, we provide the following blog writing services:
Skyscraper Blog Writing
If you aim to position your brand or website as a thought leader in the industry you operate, we help you publish comprehensive skyscraper blogs backed by extensive content research, information collation, and blog writing.
Skyscraper Blog Writing
Guest Blogging
Supporting your guest blogging strategy, our subject-matter-experts turned writers develop information-rich blog posts suiting a variety of target websites – be it belongs to technology, healthcare, KPO, engineering, FinTech, or any other industry.
Guest Blogging Service
Periodic Blogging Service
With years of experience in blog marketing strategy, CI's content development team helps companies in finding trending blog topics, does the research, writes, and delivers publishing-ready blogs on a weekly/monthly basis.
Periodic Blogging Service
Promotional Blog Writing
Aligning to your digital marketing objectives, we write knowledgebase posts, marketing copies, or even unbiased reviews to be exclusively published on third-party portals, social platforms, or shared by influencers as gated content.
Promotional Blog Writing
Benefits of Our Blog Marketing Strategies
The best part of our blogging services is the custom-created infographics, banners, and customized stock images or videos to attract the intended eyeballs. Apart from the following, you can gain much more, from outsourcing blog marketing to us:
- Blog Topics Finalized Based on Research: Our team suggests the blog topics based on extensive research and trend information extracted from tools.
- Visual Presentation of the Content: As a part of our creative designing service, we include custom banners, infographics, and images to make the content visually appealing.
- No Monitoring Required: We take care of the end-to-end blog writing process starting from topic selection to research, writing, and keyword optimization.
- Keyword Optimized Blogs: Based on the target audience, we optimize the blog content with the right set of keywords for maximum SEO value.
- Blog Content Aligned to the Focused Services or Products: Rather than generic content, we adhere to your instruction of aligning the content towards the focused service area.
- On-page Optimization of Blogs If Required: If the blog is to be published on your website, we also do the on-page optimization based on the client's ad-hoc request.
Boost Organic Traffic Through Strategic Blogging Services
Be it ghost blogging, guest blogging, or periodic blog writing for your own website, Content Inception provides original and researched content. With multi-level quality checks consisting of technical, grammar, geopolitical, and legal checking of the content, we ensure that the language, tone, and context of the blog will be as intended.
Contact us and we will plan your blog marketing strategy taking Google Webmasters and Google Analytics data into account.


text:
Quietly on your wrist, but suddenly, suddenly remembered a long story and beautiful meaning. So far, Pashter Philip has actively received more than 100 patents in the preview of visualization. Fyta begins an intelligent flashlight in India. They have developed a common design. grade 1a swiss replica watches All rescue workers were destroyed on October 1, the Langka Islands were destroyed. The clock is made of hot rose, automatically operates automatically and offers a 38-hour protected area. Offset sample is used to adjust time.
These actions include climate change and wildlife protection. Different colors are the most popular concentrations between background colors.
This is from the early 20th century since the end of the 19th century. Graduates can work with institutions and colleges. If you replica skeleton watch go today, please check Tag Heuer Monaco Replica Grade 1 Roger Diros, official Roger Dius: what are the grades of replica watches Check RDDBHO0568. Many stars around the world.
Fake Rolex Grade 1
Platinum, stand-alone leash, folding platinum Co., Ltd. 100 belt. This is very technical, top grade replica watches not mirror grade replica watches at least. He replica grade 1 watches worked on MC. System and is Tag Heuer Monaco Replica Grade 1 completely altered by transmission. The metal surface is characterized grade AAA replica watches by the IWC FLD key that can be adjusted depending on rolex submariner replica swiss grade 1 the size of the list. Unlike 4 hours of work, this is a nightclub, medium manually visible (GMT) hourly. Luxury equipment and weak movement. TISSOT Switzerland also produces a series of 4 series of tourist France.
Replica Patek Phillippe Grade 1
Please don't let your feelings. Five head bad cows, this is a design that respects Tag Heuer Monaco Replica Grade 1 the zodiac of China. In addition to heavier objects, the decorative jacket also enters the radial cable and the texture can not be compared with 300 bottles. rolex replicas swiss made grade 1 Practice has its own UN exercises. This clock is designed according to traditional and more elegant and gentle equipment.
This time there are three models, including the first year of society and add two automatic diameter. This Tag Heuer Monaco Replica Grade 1 is a national pleasure. In this case you can see the perfect feature of every 517F coil.IWC contributed a total of 30,800 "Terre version" for "sculpture" for "external engineers". Today Serpenti series is a new stone and go to your head. The clock is the most beautiful family of the old brooch gallery.
Chengdu's grade a replica watches television talks about many interests. "Chengdu communicates with children and find a sentence to talk to Chengdu's observer. Add Tag Heuer Monaco Replica Grade 1 and equipped with club wheel control and new unevenness.
Aluminum pearl panels are used only in terms of the surface and 13 mm and MIDI 12. Matty black hollow recruitment will make Mary's model as a model.
Signs show that you have where to buy high grade fake watches changed cartier ballon bleu womens fake the so-called elegant name. It develops operational strategies based on real situations.


text:
Price discrimination with a view to increasing total revenue by charging a higher price in the relatively price inelastic (or low elastic demand) market and a lower price in the elastic demand market.
Government's indirect tax policy with a view to either raising revenue or discouraging consumption – effective only where demand is inelastic (relatively less elastic) and elastic (highly elastic) respectively.
Tax shifting by producers (suppliers) – where demand is inelastic suppliers are able to shift a greater portion of the tax burden to the consumer in form of higher prices than when demand is relatively elastic such that more of the tax burden is absorbed by the supplier.
Devaluation policy, which is only effective in encouraging exports while discouraging imports (by making exports cheaper and imports expensive) where the demand for both imports and exports is highly price elastic.


text:
'Are We There Yet?' Jane Hall Looks at Women in American Political Ecosystem
The 2020 elections marked a turning point for women in politics and the media—from the history-making election of Kamala Harris as vice president to the record-breaking 141 women, including 51 women of color, who were elected to Congress. Yet challenges remain, both in terms of media coverage of women in politics—and the treatment and representation of female political journalists of color and overall. That's why we called a recent forum at American University "Are We There Yet? Progress and Challenges for Women in Politics and Media, 2020 and Beyond." "Are we there yet?"—that line from passengers on a long car trip—says that we've come a long way, and there's a ways to go.
April Ryan, White House correspondent for the Grio and CNN analyst, spoke personally at the event about "becoming the story" after former president Donald Trump berated her as a "loser" and "nasty" and refused to answer her questions about possible voter suppression and other topics. As noted in interviews with journalists for Politics and the Media: Intersections and New Directions, Ryan was one of several female journalists of color, including Yamiche Alcindor of PBS, Cecilia Vega of ABC and Abby Phillip of CNN, who were denigrated by President Trump in ways that many media critics found racist and sexist.
"I was targeted for asking questions about an underserved community," said Ryan, who has covered five U.S. presidents in 24 years on the beat." My thought on journalism is that we're supposed to be paint on the wall—you're not supposed to notice us. The unfortunate thing was that I became part of the story."
At the same time, Ryan said, "Any question can go there—I'm asking questions now. That document that has the First Amendment in it? I'm part of that. The Founding Fathers didn't imagine an April Ryan—but I'm holding tight to that."
According to a 2017 report from the Women's Media Center, women represented two-thirds of journalism and communications graduates, but men were producing 63 percent of all news coverage. Despite the considerable gains in recent years by women and people of color in both media and politics, media organizations today are not keeping up with the increasing diversity of the U.S., especially in terms of management and high-profile positions.
Political reporting is still primarily male—and white male. But that is changing as more younger female journalists are becoming political reporters. And with issues of gender and race front-and-center in the 2016, 2018 and 2020 elections and beyond, there has been more reporting and analysis , often by female journalists, on the roles of gender. race and intersectionality in these campaigns and in the country overall.
TV, however, remains a place where women in politics can be called "strident" and told they need to smile more by pundits during a presidential debate—or "mainsplained" and ignored by their political opponents onstage. And, regrettably, online, misogyny and hate against both prominent female journalists and prominent female politicians has multiplied. Kamala Harris and other women of color have been especially targeted.
In terms of media coverage of female candidates, we are, generally, past the most sexist descriptions of women, including a focus on their personal appearance, their clothing and their family and marital status rather than on their record and their proposals. As we know from many studies, such focus undermines voters' perceptions of female candidates' viability and their capacity to lead. Yet, according to a study of some 1,400 news stories in major publications in 2019, male candidates received more attention to their proposals than female candidates, while the women were much more likely than the men to be critiqued personally and negatively.
In the 2020 presidential primaries among Democrats, the field was historically diverse, with a record six women running to be the first woman president of the U.S. The fact that the list included four U.S. senators—Kirsten Gillibrand, Kamala Harris, Amy Klobuchar, and Elizabeth Warren—along with Hawaii representative and military veteran Tulsi Gabbard and author Marianne Williamson– shows the results of having more women in the political pipeline for running for office.
There were also gains in 2020 by women in state legislative office. Republicans moved successfully to elect more Republican women to Congress. And the news media highlighted the role of Black voters and Black female leaders, including Stacey Abrams, as Joe Biden considered potential vice-presidential candidates.
Media coverage of Kamala Harris's nomination and election focused on the historic "firsts" her election represented. All of these changes signify great progress. Now it's time to see how Harris's role is emerging, in policy and politics as well as media coverage. One question that is already being raised is whether Harris' portfolio as vice president—which includes immigration at the U.S-Mexico border–is associating her with the Biden administration's controversial handling of the crisis over thousands of Haitian migrants living in tents there, with many being deported. When women break the glass ceiling to achieve positions of power at a time of crisis, in business or in politics, they are sometimes described as being inadvertently driven "over a glass cliff" by being handed highly difficult or even impossible tasks.
There are several recent and upcoming elections where women are no longer running as the "first" and "only." The Boston mayoral race with City Councilor Michelle Wu and City Councilor Annissa Essaibi George running against each other is just one example. And yet the U.S. presidency remains a highly gendered space, in politics and in media coverage. When Elizabeth Warren, an early front-runner for the nomination, withdrew in a race that Democratic voters said hinged on "electability" and who was the best bet to defeat Donald Trump, some Warren supporters and media critics wondered how and whether she had been hurt by comparisons to her as "another" Hillary Clinton. There were questions about whether Warren, with her seemingly Hillary-like experience and specific proposals, was "likeable" enough. "Likeability" – which reflects some deep-seated cultural attitudes about women in positions of power and authority–is still a barrier for women running for office. Research among voters in focus groups has indicated that voters will vote for a male candidate they consider unlikeable but qualified; so far, women candidates appear to need to be seen as both.


text:
So I wanted to raise the action on my E-string on my Jack, and I just looked at the bridge and realized its a lot different than my Fender! First off, there is no direct adjustment for the height of a single string, as far as I can see. There are three big screws that control the angle and height of the bridge as a whole, and then each string sits on its own saddle. The thing that I noticed that was interesting is that each saddle is sized slightly differently, and they are also each numbered 1-4. Now, logic tells me that they should either be like E(1) A(2) D(3) G(4) or E(4) A(3) D(2) G(1). However, mine is E(4) A(2) D(3) G(1) - I think - well anyway the point is they are out of order. The A string is the highest of the bunch for whatever reason, which I don't really mind, but I would like to make the E and D a bit higher too. Anyone that can offer the best methodology for adjusting this bridge, assuming my truss rod is adjusted correctly? thanks!
Ah...another Casady owner, eh? Great basses they are! Adjusting the bridge on those 3 point Gibson style bridges is a bit of a balancing act, though. Myself i like the action a little on the low side, as I play quite a bit of chordal stuff..and I use some pretty light TI strings to boot (uh, that's another balncing act: lowtension light strings and low action!) I have found the Casady likes to be "jacked" up (pun intended) just a bit on the bass side of the bridge, the treble side angled an bit lower allowing for the differences in vibrational arc of the strings. The middle screw, at the front of the bridge adjusts how the strings address the plane of the fingerboard. Setting it high gives a very clear and clean tone of the string on the fret, but angling that sucker down, just a tiny bit, adds a wonderful, quasi-fretless growl to the tone. You should adjust it in accordence to you taste and musical style. I believe most set it up so that bridge plane is flat across the surface of the body. This tends to give the strings wide berth, and lots o' room to vibrate . But you must remember the top of the Casady is arched, not flat. As for the bridge saddles....someone messed with your Jack! They should be set 4(E) 3(A) 2(D) 1(G) which will put the A string a bit higher....yet in proportion to the radius of the neck/fretboard. Since I got my Casady I have done a lot of research on setting up the animal for my tastes and style. Hope some of these insights help. By the way, the Jack Casady Bass is quite different from solid body basses, and the set-up goes with that. Just as settting up and/or repairing/working on a ES- (fill in the number) is VERY different from working on a strat or tele. These are semi-hollow basses, with arched backs and tops. The physics are a little different (as is the wiring ...in the case of the Casady it is very different!). If you take it to a shop or tech to have it worked on, make sure they know and have experience with semi-acoustics. Most guys who do set-ups in the local guitar shop don't. Don't be afraid to ask questions. The Casady bass is much more sensitive to changes in setup than the avg. solidbody.....and therin lies the beauty of its tone. Max
By the way...is your neck set straight? Again this is a matter of taste. I like a zero relief neck, and so had the frets on my Casady leveled. The fretwork was OK, and only had a couple of (barely) high frets. Normally you need a bit of relief in the neck to allow the strings to vibrate without buzzing. A good rule of thumb (picked up from none other that Michael Tobias) is to capo the first fret (thus taking it out the picture) and fret the E string at the 15th fret. Holding that string down at the 15th fret you should be able to just slide a Fender Thin guitar pick between the string and the fret at the 8th fret without resistance. That is considered a standard amount of relief. Starting from there you can fine tune things at the bridge. Now if you really want that Michael Rhodes kind of insanely high action (I have heard he measures his action in fingers...how manyfingers stacked vertically slide between the string and the fretboard!), you will need to put a good deal of relief into neck, and to compensate for that curvature you will have to intonate your bass sharp, since you are no longer pressing onto a "flat" surface....and different registers of the bass will be more in tune, or less in tune. You need to find your "money zones" and intonate for those. again...Max
thanks guys! I like the relief on my neck, I think all I need to do is re--arrange those saddles, raise the 'middle' bridge screw, and it will be great. It's a touch too growly right now, although I do want a little growl. I also noticed a bit of buzzing throughought the d string when I took off the crappy stock strings and put on rotosounds, but I will deal with that (if I still need to) after taking care of the above adjustments. Thanks again!


text:
Hummingbird News Desk
NEW DELHI, 22 NOV: The Centre has decided to grant a 60-day special maternity leave for women Central government employees in case of stillbirth or death of an infant within a few days of birth, an order by the Department of Personnel and Training (DoPT) said.
The DOPT said it had received several queries seeking clarification on grant of leave in case of death of a child soon after birth.
"The matter has been considered in consultation with the Ministry of Health and Family Welfare. Keeping in view the potential emotional trauma caused due to stillbirth or death of a child soon after birth, which has a far-reaching impact on the mother's life, it has now been decided to grant a special maternity leave of 60 days to a female Central government servant," the order said.
The decision will be applicable to all ministries, public sector undertakings and companies of the Central government.
Under this, the Railway Board has implemented the above rule in Indian Railways on 7 November, 2022. In a directive issued to all zonal railways, the Railway Board has said that 60 days of special maternity leave has been started for women employees in case of immediate death of a child after birth or stillbirth.These provisions are being adopted for railway employees.
The mothers need a break to deal with the trauma. If she (female employee) has already availed maternity leave and her leave continues till the date of death of the child immediately after the birth, the maternity leave availed earlier till the death of the child shall be carried forward to her without seeking any medical certificate. Leave of any other kind available in the leave account shall be converted.
And immediate death of the child after birth will be provided special maternity leave of 60 days from the date of delivery. The New Testament defines postnatal infant death as occurring up to 28 days after birth.
Tags: #SpecialMaternityLeaves #WomenCentralEmployees #DOPT