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NEW YORK (Reuters Health) - Fewer than half of Americans with stable heart disease get guideline-recommended medicines before being rushed off for an invasive heart procedure, researchers said Tuesday.
Yet the costly procedure, called percutaneous coronary intervention or PCI, offers few proven benefits over drug therapy and puts patients at risk of side effects.
"I always encourage patients to be proactive members of their own healthcare team, and they certainly should be asking doctors if they are on the right medicines," said study researcher Dr. William B. Borden, of the Weill Cornell Medical Center in New York.
During PCI, a cardiologist guides a thin plastic tube to the heart via an artery to look for cholesterol plaques. Such buildups narrow the arteries and limit blood supply to the heart, which can cause chest pain and other symptoms during physical activity.
The doctor then inflates a balloon at the end of the plastic tube to break up the plaque, leaving behind a metal mesh tube called a stent to keep the artery open.
Studies show patients usually believe the procedure will cut their risk of heart attacks and death. But, in fact, it doesn't work any better than drugs for people who haven't had heart attacks before.
That became clear in 2007 after the publication of a large trial known as COURAGE that compared the PCI procedure followed by "optimal" drug therapy to treatment with the drugs alone.
On the other hand, PCI may lead to complications such as stroke, emergency bypass surgery or even death in up to one percent of patients.
In the new study, published in the Journal of the American Medical Association, Borden and his colleagues used data from more than a 1,000 U.S. hospitals to see how often patients were put on drugs before they underwent PCI.
They included more than 467,000 people with chest pain due to narrowed arteries in the heart — so-called stable coronary artery disease.
Overall, 44 percent of the patients were on guideline-recommended drugs — cholesterol-lowering statins, blood-thinning aspirin and blood pressure drugs — before they had PCI. After the procedure, the number climbed to almost two-thirds.
From the start of the study in 2005 until 2009 — two years after the COURAGE trial — those rates rose only a few percent.
"This was a 33.5-million-dollar trial, the COURAGE trial, that we found did not have much impact on practice patterns," Borden told Reuters Health. "As we as a country invest money in comparative effectiveness research, we need to also find out how to best translate those findings into clinical practice."
Experts say more than one million Americans undergo PCI every year, at a price that exceeds drug therapy by more than $10,000. The procedure may work better than medicine for some, but many do well on drugs alone.
Last year, Dr. William Boden, who led the COURAGE study but was not involved in the new research, told Reuters Health that doctors ought to think twice before they sign stable patients up for PCI.
"It would be like hitting the 'pause button,'" said Boden, medical director of cardiovascular services at Kaleida Health in Buffalo, New York. "That way, the patient could confer with his/her private or referring physician, weigh the pros and cons of each therapeutic choice, or give a trial of medical therapy a good chance to work before proceeding straight-away to urgent PCI."
But he added that the current healthcare system is not set up to favor that approach.
"There are no financial disincentives to avoiding PCI," Boden said. "On the contrary, in a fee-for-service model, physicians are paid for doing procedures."
Concluded Borden: "Hopefully our study will shine a light on the importance of providing medical therapy to patients before they receive stents."
SOURCE: bit.ly/4HWZ7 Journal of the American Medical Association, online May 10, 2011.


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This Black Zig Zag patterned outdoor cube by Majestic Home Goods features a high durability polyester exterior that makes it perfect for an outdoor setting. The polyester cover is rated with 1000 hours of UV protection, you do not have to worry about the durability or the longevity of this cube. The contemporary zig zag style can add a subtle touch of zest to your outdoor area with zig zag design that can add a break into your outdoor patio. The exterior slipcover easily zips off for machine washing, and it does not get much easy for that. Its medium size make it a flexible small piece of furniture, ideal for a seat or a footrest at 17 in x 17 in x 17 in. You are going to need a few of these cubes, because everybody that comes over is going to want their own!
The Majestic Home Goods line of outdoor pillows is the epitome of the quality and durability for all your outdoor needs. Their unique flair for creative designs and vibrant colors grants a huge variety of how you can orchestrate the decor of your space. Nothing compares to the effect these pillows can have on your outdoor space.
|Majestic Home Goods
|USA Only
|Pillow Dimensions
|17in x 17in x 17in
|One cube

subset: commoncrawl


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scratch(redirected from scratched an and find an)
Also found in: Dictionary, Thesaurus, Encyclopedia.
1. to scrape or rub a surface lightly with the nails or with a sharp or jagged instrument, particularly to relieve itching.
2. a slight wound.
3. to make shallow cuts on a surface.
4. to make a thin grating sound.
scratch(skrach) [ME. cracchen, to scratch]
1. A mark or superficial injury produced by scraping with the nails on a rough surface.
2. To make a thin, shallow cut with a sharp instrument.
3. To rub the skin, esp. with the fingernails, to relieve itching. Scratching temporarily relieves itching by soothing the cutaneous nerves, but in the long run, it may worsen the condition that caused the itching. See: pruritus
Patient discussion about scratch
Q. why do allergy effects comes usually in sorts of sneezing and scratching and more other thing like that?
A. It's because the substances released in the allergic reaction of the immune system to the allergen, like histamine, cause sensation of itching. They also cause increased secretion of mucus from the lining of the throat, which irritates the airway and cause sneezing.
You may read more here:
You may read more here:
Q. Is there any information out there regarding a severe allergy to cat scratches? Is there any information out there regarding a severe allergy to cat scratches? I am not referring to "cat scratch fever" disease, but an allergy where the site of the scratch becomes swollen and red, and the person has hives and trouble breathing. Thanks so much!
A. Greetings Humble Earthling! It sounds like you have two or more things going on. First, cat scratch fever is caused by a parasite and comes on 1 to 2 weeks after the scratch. Allergic reactions are immediate.More discussions about scratch
Now, if the site of the scratch is swollen and red, that could be due to minor infection and just the process of healing.
Now, if the site of the scratch is swollen and red, that could be due to minor infection and just the process of healing.


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SAN FRANCISCO (MarketWatch) — First Solar shares surged 10% Tuesday after the struggling company announced a draconian overhaul of its operations, capping a rally by more traditional energy stocks that drew strength from firmer oil prices.
First Solar Inc. FSLR, -0.55% said before the market open it plans to shut its plant in Frankfurt, Germany, idle indefinitely four production lines in Malaysia, and eliminate 2,000 jobs, or roughly 30% of its work force. Read about First Solar's restructuring plan.
The move reflects tough competition from Chinese solar panel makers and deteriorating market conditions in Europe, where the region's ongoing debt crisis has cut into government subsidies for renewable energy.
First Solar shares, which had lost 84% of their value over the past 12 months, rose $2.14, or 10.3%, to close at $22.96.
Meanwhile, May crude-oil futures CLK22, -51.45% jumped $1.27 to $104.20 a barrel in New York following a successful Spanish government bond sale and a rise in German consumer confidence, both signs that Europe's economic conditions are slowly turning around. Typically, a better economy signals higher energy demand. See the latest on crude-oil prices.
Higher oil prices typically prompt closer scrutiny among politicians as well. With gasoline prices hitting $4 a gallon in an election year, President Barack Obama called on Congress Tuesday to give regulators more effective tools to root out speculation in the oil market. Read about Obama's call for a stronger CFTC.
This latest jump in crude-oil prices shored up oil stocks, nudging the NYSE Arca Oil Index (XOI) 1.4% higher to 1,216.14. Refiner Valero Energy Corp. VLO, -0.84% led percentage gainers in the group, up 3.1% to $24.08 a share.
One of the few declines among major oil companies was Spain's Repsol S.A. (REP) , whose U.S.-traded shares fell 2.5%. Repsol, the majority shareholder in Argentina's YPF S.A. YPF, -0.54%, vowed to challenge the Argentine government's planned nationalization of YPF, a move announced on Monday by Argentina's President Cristina Fernandez de Kirchner. Read about Repsol's predicament.
Other energy shares on the move Tuesday included Newfield Exploration Co. NFX, +19.01% up 4.5% to $33.78 after analysts at Jefferies raised their recommendation on the stock to buy from hold.
Cabot Oil & Gas COG, -0.66% was also up sharply at $30.57, a 3.5% rebound from the previous session's selloff.
Cabot's move helped boost the NYSE Arca Natural Gas Index (XNG) 1.5% to 619.87 points.
The Philadelphia Oil Service Sector Index OSX, -0.83% rose 1.8% to 230.08 points. Noble Corp. NE, +0.54% led gainers in the group, up 3.2% to $36.29 a share.


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Black Friday should not just be about lining up the whole night to get awesome shopping deals. If you don't want to line up or are simply looking for other things to do on Black Friday other than shop with a huge crowd, try out some of our fabulous suggestions for alternative activities.
See the Great Outdoors
Really see the great outdoors by going camping, hiking, or swimming. If you're not the active type, you can simply enjoy the scenery and take pictures. Whatever your level of activity is, you can be sure that nature will take you on a great journey of discovery.


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On December 18, Asus announced a new motherboard supporting the Intel P965 Express chipset. "With superior engineering, the Commando provides unmatched overclockability, taking FSB and memory up to 2,280 and 1,300MHz, respectively." The board also offers some interesting features for gamers who like to fiddle around with their settings. The "Extreme Tweaker" feature allows you to fine-tune your system performance with the ability to adjust frequency, voltage options and memory settings among others. Another feature, the "Onboard Switch," allows you to turn your system on and off as well as reset and clear the CMOS at the touch of a button. That means you won't need to fiddle with onboard jumpers in order to repair or tweak your system.
I tried calling Asus to find out release date information and pricing, but oddly, the representative didn't quite understand what I was referring to. Anyhow, a board like this looks to be good news for DIY builders and gamers.
Asus Commando Specs:
- CPU: LGA 775 Core2Duo, Quad-Core CPU
- Chipsets: Intel P965 + ICH8R
- 6 SATA II 3Gb/s
- Supports ATI Crossfire Graphics
- SupremeFX Featuring ADI 1988b
- Extreme Tweaker
- LCD Poster
- 8 phase capless power design
- Onboard switches


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Interesting developments…
I attempted to contact Apostolic Truth Tabernacle and their pastor Reverend Jeff Sangl to no avail today. I called but the voicemail was full. Apparently I was a little late in attempting to contact them.
They have updated their site as linked above and put out a new message on the front page. It does not excuse acts of the past however and in an attempt to reach out I have created a video asking Rev. Sangl to answer some questions for me.
Looming questions
I've had a few people ask me how I was sure that the video actually occurred at the church in question. Well I was not the individual to actually do the research or break this story but I was the one who got it quite a bit of media coverage. The research was done by an individual who has a barely active twitter account under the name sockymonky. I have no idea who this person is but he certainly had his work cut out for him (I assume it's a him due to the name Mike).
This is a screenshot from their now defunct facebook page. That, along with several pictures from their website, clearly identify the unique design of the worship hall. This worship hall is identical to the one in the video.
Investigative journalism?
These are all unconfirmed but here's the scuttlebutt:
- Chad Woodall of Greensburg, IN uploaded the videos to youtube. It is unknown whether he is a member of the church or was trying to expose it.
- He is friends with Jeff Sangl on facebook.
- It was uploaded under the account Funnyman1972. (The video is no longer active–It was rumored to be taken down by youtube for "hate speech")
- This link will take you to where the video is. It now appears as private.
Whoever you are sockymonky thanks for exposing this vitriol and hatred!
I await your response Reverend.
-Paul Loebe


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Learn all about the fondant birds and the sugarpaste bees, and make adorable animal cake toppers with cake designer Sharon Wee.
Discover how to make fondant animals for cakes and treats sure to put a smile on any guest's face. You'll learn to make five basic shapes to start building cute and fun fondant animal cake toppers. Sharon's class is a great place to begin your foray into fondant modeling or elevate your existing cake-topper construction skills. In just minutes you'll create lovely ladybugs and beautiful bees before moving onto delightful ducks and proportional penguins. Sharon's no-nonsense approach will equip you with time-saving tips and gravity-defying construction techniques as you mold movement into your fondant creatures. Your fondant pig comes alive playing in a puddle, and a cute cow kicks up the celebration with a floating fondant-covered balloon. Sharon completes the class with a step-by-step guide for making her signature lovebirds with detailed beaks, bellies and wings.
If you're not delighted with your Bluprint experience, we'll make it right or give you a full refund.


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There was once a time when it was cool to have your own website address on your advertising. You were progressive. Cool. Hip! Of course, this always leads to "the next cool thing." Apparently, the next cool thing is currently Facebook. "Check out our Facebook Page!" companies herald on their print advertisements, brochures and on 50 ft. billboards. That's cool. Just be aware that Facebook is a trend and like all trends, it could end at any time.
Don't think that your shiny new Facebook Page replaces a good, old company website. It doesn't. And here are the main reasons why:
- You don't own your Facebook Page. Facebook owns your Facebook Page. According to Facebook's user agreement, Facebook asserts rights to the content you post on your Facebook Page."In addition: For content that is covered by intellectual property rights, like photos and videos ("IP content"), you specifically give us the following permission, subject to your privacy and application settings: you grant us a non-exclusive, transferable, sub-licensable, royalty-free, worldwide license to use any IP content that you post on or in connection with Facebook ("IP License")."
- Facebook can terminate your Facebook Page at any time. If your company relies heavily on Facebook as a marketing tool, just know that it could be terminated at any time and you have no recourse.
- Not everyone is on Facebook. There's still an "admission fee" to even get through the door at Facebook. Granted, the "fee" doesn't cost any money, but it does cost some amount of privacy. And not everyone is willing to pay this "fee". Subsequently, they won't be allowed into the new, hip social club called Facebook. If you're operating the majority of your marketing tactics on Facebook, be aware that you are alienating a segment of your customers.
I'm not a Facebook hater. You'll see that I check Facebook almost daily. But two of my four closest friends don't even have Facebook accounts. Facebook provides a great opportunity for marketing growth, but do not fall into thinking it is some magic bullet that'll hit all your marketing targets.
With that said, go nuts on Facebook! But don't neglect your real website because in the end, your real website will alway be there for you. Facebook? Maybe, but who knows.


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Features and Benefits:
The 12,000 lb. capacity E12 two post lift provides symmetric lifting capability, maximum room to work underneath vehicles and room to grow. It's adjustable height accommodates higher profile vehicles and provides ample headroom for day to day servicing. Its competitive price allows the budget conscious service facility room for expansion. Other features include Heavy-Duty 2-stage telescoping arms, automatic arm restraints, rubber protective door guards, single point mechanical lock release system and padded overhead shut off system.


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Doubling our Business Together: One Year After the Cisco-Citrix Partnership
I'm here today in beautiful Barcelona for Citrix Synergy. It's remarkable to think that it was only a year ago that Cisco and Citrix announced a strategic, 5-year agreement to accelerate mainstream adoption of desktop virtualization.
Last night the Cisco-Citrix alliance team met at a local restaurant to celebrate our success together. Whenever we get together we realize that our visions are so closely aligned that it's almost scary. But it's true. We just come at the same problems from different angles—and that's what makes our alliance so complementary and compelling. That's great news for you — our customers and partners — because we're going to continue to innovate together and bring more of our portfolio to market.
In the spirit of celebrating our partnership I wanted to share four interesting facts you may not know about the Cisco-Citrix partnership.
- Over the past year we've more than doubled our business together.
- Together we have deployed tens of thousands of new virtual desktops to small and large customers across the globe.
- Channel partners have increased their overall solution margin by as much as 25% by utilizing the resources in the Cisco and Citrix Partner Accelerator.
- Citrix XenDesktop is the cornerstone of Cisco's Virtualization Experience Infrastructure (VXI) solution — our strategy to deliver high-quality mobile workspace experience on any device, from anywhere.
Adios from Barcelona!
In an effort to keep conversations fresh, Cisco Blogs closes comments after 60 days. Please visit the Cisco Blogs hub page for the latest content.
0 Comments


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First, let's start with the Wonder Woman Collection I grabbed one item from this collection, and it is the Mighty Aphrodite. The combination is pretty. The larger half of the blush is described to be light pink coral. It reminds me somewhat of Nars Deep Throat. So if you love Nars Deep throat, then i would recommend this blush. Might Aphrodite is just a tad bit more pink then Deep Throat. The smaller half of the blush is just a more reddish coral colour.
Here how the packaging looks like. I'm not really in love with it, but i guess it's nice to have changes.
I love the colours, but i'm not crazy about the formula. I'm actually disappointed in the pigmentation. It's very sheer. The larger half of the blush (light pink coral colour) is more pigmented then the smaller half of the blush (reddish coral). Definitely need to layer this on if you want it to be visible.
Swatches: It was much easier getting it onto my fingers then onto my hand.
second itemthat i've acquired was from the Mac Venomous Villains Collection. I picked up this beauty powder, because i never tried any from Mac. The one I got is Blair Rose and this is like a pinky plum colour.
swatches: sorry, my flash kind of made it more warm tone colour then it should of.
The pigmentation is sheer but pigmented and I don't know if that's normal for beauty powder? I wear it sort of like a blush, because i think the colour is very beautiful. Don't be afraid of how it appears in the packaging. I wear this alone, when my face looks washed out. It gives just the right amount of colour to the face.
third itemis from Mac Peacocky Collection & i only happen to pick up one of their mega metal eyeshadow called Unflappable. I don't know how to describe this, so this is what temptalia says " it's a plummy-gray-taupe with soft metallic shimmer-sheen". I think this colour looks incredible, and i have nothing like this. I wish i had picked up more eyeshadows from this collection.
The eyeshadow is very pigmented, and i think it would look beautiful with a smokey eye look.
Now onto the permanent items...
I decided to try the Mac Select Sheer/Loose Powder. I was going through a period where i broke out a lot, and i really needed my foundation to cover my troubled area. I don't have any face powder product, besides my translucent powder from MUFE. The reason i was looking for another powder product was because, I wanted something that offered a bit of coverage while setting my foundation at the same time. Hence why i tried this.
What i discovered was - DON't BOTHER WITH POWDER, when your face is dry/flaky and breaking out. Using powder just EMPHASIS that, and it looks terrible. Sadly, i can't return this, but i figure it would come into use when i have better skin day. Perhaps i'll give this a try in the summer.
But overall, the powder on it's own has light coverage, it's very soft, and i do like it. I imagine it would be wonderful if you don't have dry skin issues.
Another product i got from the permanent line is a blush. It's called Pinch O' Peach and it's a sheertone blush. I'm absolutely in love with the sheertone formula! It's feels very velvety and creamy when i swatch it. The colour payoff is incredible, and i love the fact that this shade is not shimmery. Sometimes i just want a MATTE coloured blush. They always look great when i'm trying to do a natural look. I'm definitely going to look out for more Sheertone formula blush from Mac from now on.
btw i was told by the SA that MAC is bring out new blushes? I don't remember if she said it was the cream formula ones, or the powder one, but they are up to something she said. Anyone else knows anything about this ?
LASTLY, i can not go to Mac and not pick up any of their lipsticks! Welcome the two that has now joined my lipstick family Mac Costa Chic, and Chatterbox. Costa Chic is a frost coral colour & Chatterbox is a amplified pink. They are both bright shades
left is Costa Chic and right is Chatterbox
...and that is all! Thanks for viewinggg


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SAN FRANCISCO (MarketWatch) — Shares of J.C. Penney Co. fell in after-hours trading on Wednesday after the struggling retailer announced a restructuring plan that would result in the loss of 2,000 jobs.
After the market's close, the department store said it will close 33 underperforming stores for an annual savings of about $65 million. J.C. Penney JCP, -3.74% expects pre-tax charges of $26 million in the fourth quarter and $17 million in future periods from the closures and the layoffs. It operates about 1,100 stores across the U.S. Shares were down 0.9% after volatile swings immediately following the news.
Discuss key earnings announcements before and after results come in. Learn more
Shares of CSX Corp. CSX, -0.51% dropped 2.8% in extended trading. The railroad operator said fourth-quarter earnings fell to $426 million, or 42 cents a share, from $449 million, or 44 cents a share, a year earlier. Revenue rose 5% to $3 billion in the quarter. Analysts surveyed by FactSet had forecast CSX to earn 43 cents a share.
AOL Inc. US:AOL shares edged up 0.1% in after hours. The media company said it has teamed up with Hale Global, an investment holding company, to create a new entity that would operate its local news unit Patch. The new company will be operated and majority owned by Hale Global.


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While managing a busy Chicago restaurant that was part of a major hotel on Michigan Ave., Diane Baldemor, PTS-II, wasn't thinking about pursuing a career in the healthcare field. She was enjoying her work and the challenges of motivating the staff and keeping patrons happy. However, a trip to the gym during her off hours changed her outlook and, as a result, her career path took a dramatic turn.
"I was on a treadmill and I saw the lady next to me who had multiple sclerosis working with a physical therapist. The PT was making such a real difference in her life and that's what I really wanted. I wanted to impact people that way," Diane said. This realization, along with the downturn in the economy, led Diane to consider a career in the healthcare field.
"There's such a sense of professionalism here. Everyone has set a goal to be great in whatever field they chose."
— Diane Baldemor, D.P.T.
"My parents are both in the medical field, and I didn't want to go that route initially. But, I got nervous for my future in the hotel/restaurant management industry in a bad economy. I enjoy working out and being physically active, so I started researching physical therapy. I decided I really liked the field and the opportunity it offers to do something meaningful," she said. After observing physical therapists in a variety of workplace settings and volunteering at a hospital and pediatric clinic, Diane decided to apply to Midwestern University's Physical Therapy Program. "When I visited the campus, I felt welcomed. I came from a huge university and it was difficult but fun at the same time," she relates. "For my graduate degree, I wanted something that was more intimate because this was such a huge transition for me."
At Midwestern, she found a supportive atmosphere and faculty members who are both knowledgeable and encouraging. "Starting over as a student is the biggest challenge I've had so far. The work load is very challenging and with Midwestern being on quarter system, it's very fast-paced," Diane said. "It really helps that professors are very encouraging and want to help you reach your goal of working in the field," she said.
Diane thinks the overall atmosphere and focus on healthcare at the University also helps students succeed. "There's such a sense of professionalism here. Everyone has set a goal to be great in whatever field they chose. I am taking classes with students in all the other programs and everyone is willing to help each other," she said. Diane also believes she is learning valuable skills for her future career in healthcare. "Here I get to practice communication skills with students in other programs in ways that I think are similar to what I'll experience after I graduate. Midwestern is prepping us for the future because we're all going to be in health professions."
When not in classes, Diane keeps a very active schedule that includes playing paintball with friends, dancing, and doing yoga. "Being from the hotel and restaurant world, I also am an avid foodie and I love trying out new and unique local restaurants," she added.
One of the major undertakings for the first-year physical therapy class was the Halloween Fest. This popular event is coordinated by several student groups and draws thousands of area children and their parents for a safe trick-or-treating event and a haunted house. Diane was one of the class leaders for the Fest and was able to tap into her management expertise to make sure everything ran smoothly. "It was a lot of fun and brought back some of the planning skills and creativity I had in hotel management," she said.
As she continues with her studies, Diane is excited about her future and the many opportunities open to physical therapists. "I am looking forward to learning more about the PT field and trying to figure out where I fit in that niche of physical therapists," she said. "I can't wait to graduate and get started."
Diane Baldemor, D.P.T., Class of 2014.


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date ideas
Chai Street Valentine's Menu
- Feb 06, 2018
- 0
Looking for a place to take your loved one this February that has twinkling lights, delicious drinks, and the taste of something exotic? Your friendly neighbourhood Indian Street Kitchen is offering up a special Valentine's Day menu.
We'll be offering a seafood starter served with a specially-made seafood Valentine's Thali (made with love), a homemade dessert and a glass of Prosecco – for only £19.99pp.
Thalis are a great way to experience Indian street food, as the meal presents six dishes with perfectly balanced flavours from spicy to sharp, from sweet to salty.
Our Valentine's Thali is a specially designed Seafood Thali which includes a sword fish curry, a prawn curry, a lentil dal, spiced potatoes, cooling yogurt raita and sharp lemon pickle. All served with soft fragrant basmati rice, crispy poppadum's and a fresh mix salad.
Not a fish fan? You can swap out your Fish dishes with chicken/lamb or vegetarian alternative.
If you haven't managed to plan your Valentine's Day then don't, our Valentine's Thali offer will be running until the 28th February.
For more information, or to book, please contact us.


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Thomas Hardy's bonfire nightscape
"Had a looker-on been posted in the immediate vicinity of the barrow, he would have learned that these persons were boys and men of the neighbouring hamlets. Each, as he ascended the barrow, had been heavily laden with furze faggots, carried upon the shoulder by means of a long stake sharpened at each end for impaling them easily—two in front and two behind. They came from a part of the heath a quarter of a mile to the rear, where furze almost exclusively prevailed as a product.
Every individual was so involved in furze by his method of carrying the faggots that he appeared like a bush on legs till he had thrown them down. The party had marched in trail, like a travelling flock of sheep; that is to say, the strongest first, the weak and young behind.
The loads were all laid together, and a pyramid of furze thirty feet in circumference now occupied the crown of the tumulus, which was known as Rainbarrow for many miles round. Some made themselves busy with matches, and in selecting the driest tufts of furze, others in loosening the bramble bonds which held the faggots together. Others, again, while this was in progress, lifted their eyes and swept the vast expanse of country commanded by their position, now lying nearly obliterated by shade. In the valleys of the heath nothing save its own wild face was visible at any time of day; but this spot commanded a horizon enclosing a tract of far extent, and in many cases lying beyond the heath country. None of its features could be seen now, but the whole made itself felt as a vague stretch of remoteness.
While the men and lads were building the pile, a change took place in the mass of shade which denoted the distant landscape. Red suns and tufts of fire one by one began to arise, flecking the whole country round. They were the bonfires of other parishes and hamlets that were engaged in the same sort of commemoration. Some were distant, and stood in a dense atmosphere, so that bundles of pale straw-like beams radiated around them in the shape of a fan. Some were large and near, glowing scarlet-red from the shade, like wounds in a black hide. Some were Maenades, with winy faces and blown hair. These tinctured the silent bosom of the clouds above them and lit up their ephemeral caves, which seemed thenceforth to become scalding caldrons. Perhaps as many as thirty bonfires could be counted within the whole bounds of the district; and as the hour may be told on a clock-face when the figures themselves are invisible, so did the men recognize the locality of each fire by its angle and direction, though nothing of the scenery could be viewed.
The first tall flame from Rainbarrow sprang into the sky, attracting all eyes that had been fixed on the distant conflagrations back to their own attempt in the same kind. The cheerful blaze streaked the inner surface of the human circle—now increased by other stragglers, male and female—with its own gold livery, and even overlaid the dark turf around with a lively luminousness, which softened off into obscurity where the barrow rounded downwards out of sight. It showed the barrow to be the segment of a globe, as perfect as on the day when it was thrown up, even the little ditch remaining from which the earth was dug. Not a plough had ever disturbed a grain of that stubborn soil. In the heath's barrenness to the farmer lay its fertility to the historian. There had been no obliteration, because there had been no tending.
It seemed as if the bonfire-makers were standing in some radiant upper story of the world, detached from and independent of the dark stretches below. The heath down there was now a vast abyss, and no longer a continuation of what they stood on; for their eyes, adapted to the blaze, could see nothing of the deeps beyond its influence. Occasionally, it is true, a more vigorous flare than usual from their faggots sent darting lights like aides-de-camp down the inclines to some distant bush, pool, or patch of white sand, kindling these to replies of the same colour, till all was lost in darkness again. Then the whole black phenomenon beneath represented Limbo as viewed from the brink by the sublime Florentine in his vision, and the muttered articulations of the wind in the hollows were as complaints and petitions from the "souls of mighty worth" suspended therein.
It was as if these men and boys had suddenly dived into past ages, and fetched therefrom an hour and deed which had before been familiar with this spot. The ashes of the original British pyre which blazed from that summit lay fresh and undisturbed in the barrow beneath their tread. The flames from funeral piles long ago kindled there had shone down upon the lowlands as these were shining now. Festival fires to Thor and Woden had followed on the same ground and duly had their day. Indeed, it is pretty well known that such blazes as this the heathmen were now enjoying are rather the lineal descendants from jumbled Druidical rites and Saxon ceremonies than the invention of popular feeling about Gunpowder Plot.
Moreover to light a fire is the instinctive and resistant act of man when, at the winter ingress, the curfew is sounded throughout Nature. It indicates a spontaneous, Promethean rebelliousness against that fiat that this recurrent season shall bring foul times, cold darkness, misery and death. Black chaos comes, and the fettered gods of the earth say, Let there be light.
The brilliant lights and sooty shades which struggled upon the skin and clothes of the persons standing round caused their lineaments and general contours to be drawn with Dureresque vigour and dash. Yet the permanent moral expression of each face it was impossible to discover, for as the nimble flames towered, nodded, and swooped through the surrounding air, the blots of shade and flakes of light upon the countenances of the group changed shape and position endlessly. All was unstable; quivering as leaves, evanescent as lightning. Shadowy eye-sockets, deep as those of a death's head, suddenly turned into pits of lustre: a lantern-jaw was cavernous, then it was shining; wrinkles were emphasized to ravines, or obliterated entirely by a changed ray. Nostrils were dark wells; sinews in old necks were gilt mouldings; things with no particular polish on them were glazed; bright objects, such as the tip of a furze-hook one of the men carried, were as glass; eyeballs glowed like little lanterns. Those whom Nature had depicted as merely quaint became grotesque, the grotesque became preternatural; for all was in extremity."
Thomas Hardy, The Return of the Native


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Sold Secure Approved & Police Approved Ground Anchors, Security Chains and more!
We manufacture and sell the Torc Ground Anchor, Protector Security Chains, Shed Shackle, Anti-Pinch Pin and other innovative and high quality security products:
- Manufactured in the UK to our specification
- Independently certified by Sold Secure and the Police
- Quality, reliability and great customer service are our priorities
- No-nonsense explanations of the strengths and weaknesses of our products to help you make the right choice
- We only sell products we are happy with – we do not re-sell low quality products just to make a profit
- We trade and behave honestly
- We respect our customers and the environment
We started out with torc-anchors.com but our range has widened to include many other items so this is our new web site.
Oh, and our products are not just for bikes! More about us


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Fishing can be a phenomenal and fun activity for children and youngsters. Fishing can be a very fulfilling sport; you and your family can fish rather than dealing with the hectic routines of day to day life in Yermo, and enjoy the outdoors. Families regularly enjoy the outside air, find out about the earth, and even create great memories. Best of all, fishing is quality time spent together talking, laughing and sitting next to each other. It can be a perfect game for little children, on the off chance that you present it emphatically. For some families, the experience of fishing with live bait, and catching fish that later become dinner, can be a memory making experience that lasts a lifetime.
Here are some of the thought to make your fishing trip successful in Yermo with your kids.
Yermo Live Bait Well
The Conveniences Of An Angling Overview
Fishing can be a phenomenal and fun activity for children and youngsters in Khasab. Fishing is a compensating sport; your family can make tracks in an opposite direction from hectic routines to enjoy the outside air, find out about the earth, and even create persistence. Best of all, fishing is quality time spent together talking, laughing and sitting discreetly next to each other. It can be a perfect game for little children, on the off chance that you present it emphatically.
Here are some of the important points through which you can make your fishing trip successful in Khasab with your kids.
1. Location
In case you're fishing from shore, discover an effortlessly available area. A short drive and a short stroll to your spot are ideal; recall, the objective is to acquaint an extraordinary game with your new fisherman. You don't need your youngster so drained when you arrive that he or she will be miserable and not able to appreciate fishing.
During this presentation procedure, set your kid up for accomplishment by picking a spot where you know there are fish. On the off chance that conceivable, pick a shallow zone where minor fish can be seen.
2. Time Your Trip
The period of time spent fishing will be dictated by your kid's age. Be set up to remain just the length of your child is interested; perhaps a half hour or so on your first trip. Try not to transform what can be another experience into a difficult marathon for your little one.
3. Snare, Line, and Sinker
Provide your kid with simple to-utilize handle. There are an assortment of basic posts accessible composed particularly for little children. These short poles, once in a while with child agreeable characters, are engaging and less disappointing for little hands.
It will be physically unthinkable for your young youngster to snare the worm, cast the line, and reel in the fish alone. There are approaches to beat these impediments. You can cast for your youngster and after that give your kid the bar. You can likewise connect a sinker so your youngster can discharge the line straight into the water.
4. Supplies
Make a rundown to confirm with your youngster the provisions you will require. Incorporate things, for example, sustenance, water, sunscreen, emergency treatment outfit, lifejackets, and a camera.
5. Remain Safe
Water mishaps are particularly worried to guardians of youthful kids. While selecting your fishing spot, search for stable ground and know about dangers, for example, shakes that kids could slip on into the water. In case you're fishing close quick moving water or from a vessel, kids ought to dependably wear individual flotation devices, ordinarily called life vests. Educate your youngster security systems, for example, bringing down the bar and keeping it underneath the midsection.


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News Release
Media Contact: TPWD News, firstname.lastname@example.com, 512-389-8030
May 1, 2012
Texas State-Fish Art Contest Winners Announced
ATHENS—Officials at the Texas Freshwater Fisheries Center have announced the winners of the Texas division of the Wildlife Forever State-Fish Art Contest.
The annual contest is open to all Texas students in public, private and home schools and is judged in four grade-level divisions: K–3, 4–6, 7–9 and 10–12. First-place winners in each grade-level division advance to the national competition. National winners will be announced at the Wildlife Forever State-Fish Art Contest Expo to be held in Little Rock, Arkansas, in June.
The Toyota Texas Bass Classic funds cash prizes for Texas winners: $1,000 for first place, $750 for second place and $500 for third place in the 10–12 division. Prizes in the K–3, 4–6 and 7–9 grade levels are $100 for first; $75 for second; $50 for third.
First-place Texas winners also receive a travel allowance for themselves and their family to attend the Texas division contest expo to be held at the Texas Freshwater Fisheries Center in Athens on June 9.
Texas winners in the K–3 grade level division are: First Place, Allister Huang, Sugar Land; Second Place, Nancy Shao, Sugar Land; Third Place, Rohun Kulshrentha, Flower Mound.
Texas winners in the 4–6 grade-level division are: First Place, Erin Werner, Santa Fe; Second Place, Jin Lee, Plano; Third Place, Candice Ma, Sugar Land.
Texas winners in the 7–9 grade-level division are: First Place, Nasa Xu, Katy; Second Place, Sebastian Beil, Houston; Third Place, Josue Montemayor, Pasadena.
Texas winners in the 10–12 grade-level division are: First Place, GiGi Barker, Village Mills; Second Place, Peyton McCown, Willow Park; Third Place, Luis Castillo, Irving.
Honorable Mentions were awarded by the Texas judges to the following students.
Grades K–3: Austin Purvis, Corsicana; Codi Dulworth, Corsicana; Branch Brooks, Corsicana; Andrew Smith, Corsicana; Austin Naylor, Corsicana; Jeddie Barker, Village Mills; and August Herbrich, La Grange.
Grades 4–6: Kaufman Riddle, Corsicana; Bryce Harrison, Corsicana; Jennifer Li, Sugar Land; Daniel Pahutan, Richmond; Kayla Treviño, Richmond; Cassie Chen, Richmond; and Tanmay Karandikar, Coppell.
Grades 7–9: Tyler Jones, Warren; Sujal Manonar, Coppell; Charlie Neuendorff, Fayetteville; Loran Lockhart, Liberty; Shellby Salt, Stephenville; Kylie Ting, Sugar Land; and Kriti Sinha, Irving.
Grades 10–12: Jessica Seagroves, Dallas; Coreena Rego, Plano; Magdalena Bohanos, Liberty; Alexis Ambriz, Houston; Aubrey Clemens, Dallas; Holli Harris, Liberty; and Bonnie Leung, Spring.
The State-Fish Art Contest is a project of Wildlife Forever. Located in Brooklyn Center, Minnesota, Wildlife Forever is a non-profit multi-species conservation organization dedicated to conserving America's wildlife heritage. Working at the grassroots level, Wildlife Forever has funded conservation projects in all 50 states, committing millions of dollars to "on-the-ground" efforts. Wildlife Forever supports habitat restoration and enhancement, land acquisition, research and management of fish and wildlife populations.
EDITORS NOTE: Images of all first, second and third-place winners in the Texas division of the State-Fish Art Contest can be found at http://tpwd.texas.gov/newsmedia/news_images/.
On the Net:
- http://tpwd.texas.gov/fishart
- http://www.wildlifeforever.org/contest
- https://www.facebook.com/pages/Texas-Freshwater-Fisheries-Center/128462433868391
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You CAN have both - low noise AND high efficiency
For noise-critical portable applications, such as GPS receivers, connectivity, and sensing, power supply designers always had to choose between longer battery run time (from higher efficiency) or higher signal chain performance (from the increased sensor sensitivity possible with a quieter power supply). For line-powered industrial or communications equipment applications, designers have been forced to dissipate significant amounts of power in LDOs to achieve the desired noise performance. Achieving both low noise and high efficiency was impossible.
Simplelink™ Academy
SimpleLink Academy provides a comprehensive and interactive learning experience for the SimpleLink portfolio of devices covering all phases of development from basic examples to more advanced optimization techniques that help fine tune your design. SimpleLink Academy is housed on our TI Resource Explorer and lives within each SDK.
Watch the overview videos to find out more, or click on your technology and software development kit to be redirected to the SimpleLink Academy modules.
Connect: SimpleLink™ MCUs
Welcome to Connect, TI's weekly video series covering all things connectivity. We will bring in experts to talk about the latest industry trends and TI's SimpleLink technology, hand
iOS/Android-Based Firmware Updates for SimpleLink Devices Training Series
Bluetooth 5 Overview on the SimpleLink CC2640R2F wireless MCU
Introducing TI's fully qualified hardware and software solution for Bluetooth 5.
TI Virtual Demo Library
This training series showcases TI Demos, Tools, EVMs, and TI Designs. It is a great resource to quickly find example end applications of TI products.
Introduction to the SimpleLink SDK
Provides details of the software, hardware, tools, and resource components that make up the SimpleLink SDK software development kit, with an overview of TI-RTOS concepts and labs illustrating how to use the SDK to build and port applications between SimpleLink devices.
Single-chip Smart Water Meter with Dual-band RF and InfraRed port
Hundreds of millions mechanical water meters are deployed around the world today. Market pressure pushes water utilities to add intelligence and allow for automated readout and billing on top of water waste control. RF-enabled electronic flow measurement modules provide a cost-effective solution without full meter replacement and are the main building block for fully electronic smart water meters with impeller principle.
Wireless Network Challenges and Solutions for a Smarter Grid IoT
The Internet of Things (IoT) is now part of the smarter grid through the adoption of IPv6 communications networks. These 6LoWPAN-based networks address key concerns such as standards-based interoperability, reliability, low power, and long-distance connectivity.
Texas Instruments Security Webinar Series
In this series, you will gain an understanding of the TI security framework and the various industry-recognized security enablers that TI supports.
SimpleLink™ Academy for Wi-Fi® CC3x20 SDK
Below are the SimpleLink Academy modules associated to the SimpleLink CC32x0 Wireless MCU.
SimpleLink™ Academy for Bluetooth® low energy CC2640R2 SDK
Below are the SimpleLink Academy modules associated to the SimpleLink CC2640R2 Wireless MCU.
SimpleLink™ Academy for MSP432 SDK
Below are the SimpleLink Academy modules associated to the SimpleLink MSP432 Host MCU.
Webinar Series
Join our webinar series, as we explore different industry trends and technologies across our diverse product portfolio. Over the coming months, our experts will cover the latest analog, power management and embedded processing topics, across both automotive and industrial applications.
RFID Training Series
As innovation is progressing, confusion around RFID and RF terminology is increasing. This training series takes a closer look at use cases, weighs technology pros and cons and helps make your technology selection straight forward.
Near Field Communication (NFC) Training Series
Near Field Communication (NFC) is a radio technology enabling bi-directional short range wireless communication between devices to make life easier and more convenient for worldwide consumers by simplifying transactions, digital content exchange, and electronic device connection with a touch.
SimpleLink Wi-Fi CC3200 Project 0 Series
These videos support the software tool series for SimpleLink™ Wi-Fi CC3200
- SimpleLink™ Wi-Fi CC3200 Project 0: Energia IDE
- SimpleLink™ Wi-Fi CC3100 Project 0: IAR Embedded Workbench
- SimpleLink™ Wi-Fi CC3100 Project 0: Code Composer Studio IDE
SimpleLink Wi-Fi CC3100 Project 0 Series
These videos support the software tool series for SimpleLink™ Wi-Fi CC3100
- SimpleLink™ Wi-Fi CC3100 Project 0: Energia IDE
- SimpleLink™ Wi-Fi CC3100 Project 0: Microsoft Visual Studio
- SimpleLink™ Wi-Fi CC3100 Project 0: IAR Embedded Workbench
- SimpleLink™ Wi-Fi CC3100 Project 0: Code Composer Studio IDE
TI SimpleLink™ Sub-1 GHz Wireless Solutions for the IoT: Robustness & Long Range (3 Part Series)
Sub-1GHz gives you kilometers of range with very low power consumption. The RF bands are license-free and the robust co-existence technology solves the increasing problem of interference from other wireless systems. Sub-1GHz is suited for applications running on small batteries: Metering and smart grid, alarm and security and home automation.
TI Bluetooth Smart tutorial - How to get started (3 Part Series)
The BLE 3 part series targets applications with low-power, low-latency and low-throughput requirements.


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House Cleaning Packages
Not enough hours in the day to get everything done around the house? Most people are too busy to even think about house cleaning. Let Merry Maids of Pickering and Ajax worry about it for you.
Merry Maids provides house cleaning packages to give you more free time. While we take care of your house cleaning needs, you can focus on spending time with your friends, family, pets, or just doing the things you never have time to do.
Imagine coming home to a beautifully cleaned home, knowing you didn't have to lift a finger. You can just walk in the door, relax and enjoy your surroundings.
We've been cleaning homes since 1979, which means we've got the experience, knowledge and reputation for quality that our customers want when it comes to house cleaning. We know each home has different cleaning requirements, which is why we've developed different cleaning packages to suit specific cleaning needs. Check out our cleaning packages below to find one that's right for you. If you don't know which house cleaning package to choose give us a call. At Merry Maids of Pickering and Ajax we're always happy to help.
Reasons to choose Merry Maids of Pickering and Ajax:
- Customized cleaning services
- FREE in-house cleaning estimate
- Bonded and insured maids
- 100% satisfaction guarantee
- Weekly, biweekly, one-time cleanings, and move-in and move-out cleaning services available
- Additional services available
Budget-Minded Cleaning Package
Don't have a big cleaning budget? No problem! Merry Maids of Pickering & Ajax can focus on just the essential areas with our Budget-Minded Cleaning Package. Starting from $95.00 (plus HST) on a weekly/biweekly basis, we focus on rooms that need the most attention.Areas included:
- Kitchen
- Family room
- Master bathroom
- A room of your choice
Entertainer's Dream Cleaning Package
Spend more time hosting and let Merry Maids of Pickering and Ajax look after the cleaning.
Invitations have been sent and your guests are looking forward to an evening at your home. Make sure it looks its best with Merry Maids of Pickering & Ajax. Our Entertainer's Dream Cleaning Package focuses on the more public areas of your home. Starting from $135.00 (plus HST) on a weekly/biweekly basis, we can make sure you put your best foot forward and become the envy of your friends.Areas included:
- Kitchen
- Family room
- Living room
- Dining room
- Powder room
- Main floor hallways
- Foyer
- Stairs
Clean For Show Package
Merry Maids of Pickering and Ajax maintains your home's appearance until it's sold.
Selling a home can be a challenge. Let Merry Maids of Pickering & Ajax help keep your home looking like new with our Clean For Show Package. Starting from $135.00 (plus HST) on a weekly/biweekly basis, you can focus on selling your home while we take care of the cleaning.
Full Package with a Twist
Get the best of both worlds with Merry Maids of Pickering and Ajax!
Can't decide between a partial clean and a whole home clean? Why not get both! Alternating each week, you will receive one visit focusing on your bathroom, foyer and kitchen while your next visit focuses on a full cleaning of your entire home. Customized to suit your home's specific needs, price points will be established after a FREE Cleaning Consultation.
Sparkle and Shine Cleaning Package
Let Merry Maids of Pickering and Ajax clean your home from top to bottom.
With our Sparkle and Shine cleaning package, Merry Maids can get your home looking its very best. Starting at $280.00 (plus HST) for a one-time clean, we perform a thorough cleaning of your entire home, including all doors, door frames, baseboards and window sills. Leave the cleaning to Merry Maids of Pickering & Ajax and enjoy more time with the things you love.


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We're a little more than three days away from the Major League Baseball trading deadline and the rumor mill keeps churning out deals to tantalize fans of contenders and also-rans alike. The guys making the trades are less enamored with the rumors, however, and are blaming the resulting damage control for making it impossible to pull off any actual trades.
"We know what the truth is, and we can laugh about it," Blue Jays G.M. J.P. Ricciardi told USA Today. "But when it gets it out there, now you've got to explain to the player why it's not true. Why that team never called. You spend half of the time putting out fires and never getting anything done."
That's pretty rich from a guy who made a public announcement that he was putting his star pitcher Roy Halladay on the trading block. It's understandable that players are going to get thrown by hearing their name thrown into trades, whether they're into the idea or not. That's not the problem with the article, though. The problem is that it is a front for another tired attack on the web.
It's the same tired song that "mainstream" media outlets have been peddling for a long, long time. Peter Gammons, who has never once reported a fraudulent trade rumor, takes up the banner.
"This stuff is just driving everybody crazy, and it's getting worse and worse," Gammons says. "It's like there's 10 new trade rumors on the Internet every hour. There is so much stuff thrown out there, people can't differentiate between fact and fiction. People have an insatiable thirst for this stuff, but general managers get so tied down with this stuff, you can't even get ahold of them this time of year. It's just insane."
That's even richer than Ricciardi's comment. Gammons, Ken Rosenthal and the rest of the MLB insiders who lard columns with rumor after rumor and whisper after whisper bemoaning the fact that people can't differentiate between fact and fiction because of the big, bad Internet. And it makes it harder for Gammons to get someone on the phone, which means he might actually have to wait until he gets the story right instead of getting it first.
MLBTradeRumors.com takes a few hits in the article, which perfectly illustrates how wrongheaded the finger-pointing is in the first place. That site is, more than anything else, a clearinghouse for the rumors being put forth by newspapers, ESPN, Fox Sports and all the other outlets that think it's okay for them and only them to report trade talks. Everyone else is just speculating, you see, even if nobody is worried half as much about getting stories right as they are about getting the stories out first.
Josh Alper is a writer living in New York City and is a contributor to FanHouse.com and ProFootballTalk.com in addition to his duties for NBCNewYork.com.


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Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
Be the first lehighvalleylive.com user to add photos or videos of Hollywood Video
In ShortWhat began as a small video rental store in Portland, Ore., in 1988 has grown to more than 2,000 locations across the U.S. From new releases to genre classics and indepenent films, Hollywood Video provides comedy, drama and horror flicks for a fraction of the ever-rising price of a movie ticket. Stores also offer previously-viewed DVDs for sale, video game rentals and must-have movie...
Hollywood Video can be found at W Main St 155. The following is offered: Video Rental & Retail. The entry is present with us since Sep 10, 2010 and was last updated on Nov 14, 2013. In Somerville there are 1 other Video Rental & Retail. An overview can be found here.
Hollywood Video Incorporated is located at 155 W Main St, Somerville, NJ. This business specializes in Movies & Film.


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It's no small achievement that successful multinational corporations make products that engender loyalty and become household names throughout the world. A flawless go-to-market strategy convinces consumers in multiple countries that those brands are, in essence, local, tailored to their tastes and designed to meet their needs. Understanding cultural nuances and engaging diverse populations the world over is key to getting it right and distinguishes international corporations from their truly global peers.
IRC Institute is a Global Thought Leadership Community.More about IRC Institute


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The TRIPP TRAPP Baby Set is made specifically for the TRIPP TRAPP from STOKKE. It is made of the environmentally friendly plastic material that is recyclable and safe for children. The Baby Set includes a seating rail and a hi back. It can easily be attached to the TRIPP TRAPP highchair to provide additional support and stability as well as allowing a baby as young as 6 months old to join the family meal at the dining table. The Baby Set provides more comfort and support which encourages the child to interact more with the family.
The baby set consists of high back and rail supports. Your child can start using Tripp Trapp with the Tripp Trapp Baby Set when they are able to sit up unaided, usually around the age of 6-9 months. It can be used until your child is approximately 3 years, providing protected seating for your child. The baby set is available in the same colour range as the Tripp Trapp chair.
The iconic Tripp Trapp® chair was the first high chair of its kind when designed by Peter Opsvik in 1972. Made of solid European beech wood, its intelligent design grows with your child, providing a comfortable, ergonomic seat at any age. It has been made to fit right up to your dining table to bring your baby into the heart of your family, allowing your little boy or girl to eat, learn, play and develop alongside you.
Comfort & Design
Bring your baby into the dining table from the begining of his or life. The Pkolino Siesta High Chair is the perfect accessory to include your child into all your meals. This chair can easily be moved around your kitchen and dining room with the set of wheels. These wheels are perfect for wooden floors to prevent scratching. And the brakes will stop any other childre from running and playing with the chair and little bub.
Look at all the functions the Siesta highchair has for you and your baby: the five reclining positions can let the baby peacefully sleep in the same room as you finish the rest of your tasks. With nine different height positions, your baby can easily stay right next to the countertop as you cook. He or she will be able to sit right next to any kind of table thanks to this highchair.
Choose the most appealing color to perfectly match your style with Siesta high chair. A soft fabric to perfectly nestle your baby. A dishwasher friendly tray that can easily be removed if the toddler makes a small disaster. A five point harness to keep the baby in place and safe. A one hand, compact fold that can easily fit into any closet or compartment for storage.
Simplify your home by replacing three pieces of gear to meet every phase of a child's life, from newborn to toddler. This portable high chair can transform into a baby recliner or baby swing and it can be rolled through out the house.
Your baby will lounge comfortably in this portable high chair with a reclining seat. The height adjustments are quite handy to align your baby to your level whether sitting at the table, couch or floor.
The dishwasher safe double tray makes clean up a breeze after diner or snack time.
The Tatamia will be an asset to any home
For newborn through toddler converts for different functions:
Appropriate From:
Shipping Information:
The world's most modern and highest baby high chair is the Bloom Fresco!
The Fresco baby high chair features ultra modern metallic frame options engineered with the understanding that kitchen, dining & living spaces are now central to the design of the modern home.
As the world's highest high chair, the Fresco baby high chair offers a 3-position recline system (fully lie flat newborn craddle, semi recline and upright seat) easily activated using a light touch pull handle, 360 degrees swivel and a pneumatic easy up/down height adjustment allowing your baby to join the family at the dining table or the modern breakfast bar; starting from birth, all the way to school age. In the cradle mode the newborn baby is up and away from the ground, safe from pets & household dust. Parents and the baby are able to experience the so important eye to eye contact, critical in the first formative months.
The removable sculpted booster seat in this baby high chair is ideal for smaller infants since it's engineered to direct spills away from the seat unit. The removable click in/click out aluminum safety bar is designed to be used in the three recline positions and the 5 point safety harness with padded shoulder straps and bloom smart buckle is child-proof release and keeps your little one safe at all times. Want to move it around? The large, scratch free wheels concealed in the base let you do it easily.
The adjustable feeding tray is scratch resistant and anti slip and the removable reinforced aluminum footrest comes with 3 adjustable height positions. The push button and quick release harness straps are meant to let you adjust the height with no effort, as well as remove them to convert it into a play seat for kids up to 79 lbs. This baby high chair is easy to wipe clean, not only the seat unit but also the seat pads.
Product Specifications
Unlike conventional high chairs, and continuing with the 2-in-1 product philosophy of Mima, Moon further offers the option to convert the product into a junior seat
The Mima Moon High Chair features 2 seat units, meaning that it may be used throughout the evolutionary stages of the child by simply removing the upper seat when the child is old enough.
The innovative design of the Mima Moon High Chair allows for a functional and intelligent high chair, with easy height adjustment, seat recline system and simple tray removal.
Easy height adjustment by pressing a button on the chairs base with the foot.
Multi-angle seat recline system; from seated to a reclined position for newborns.
The Mima Moon High Chair features elegant and innovative materials, such as transparent poly carbonate resulting in a light and aerodynamic feel. Hints of color may be added through the use of white, black or camel seat pads and cushions.
The comfortable seat pads, which are thermoformed, lightweight and resistant, protect the baby and can be easily cleaned. Available in white, black and camel, all seat pads include a seat harness.
What's included
The multifunctional, ultra-compact high chair that easily accommodates a child's growth. From birth, the Siesta can be used as a recliner or as a high chair for feeding, playing and resting. The removable tray and multiple height positions allow child to sit right at the table.
The Siesta follows a child from birth through the toddler years. The multi-functional high chair can be used as a comfortable recliner, perfect for keeping a young baby close. As the child grows, the five recline positions and nine height positions provide a perfect spot for relaxing, eating or playing. Dinner will truly be a family affair, as the Siesta's multiple height settings and removable tray allow child to sit at the dinner table.
Folded: 12 1/2" x 35"Unfolded: 29 3/4" x 23 3/4" x 41 1/4"Weight: 24 lbs
Modern and Stylish
The latest addition to the Clek family
Sleek Contemporary
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Catan: Oil Springs Night at Goethe Institut
Eureka! Oil has been discovered on Catan! That's right, oil has been discovered on the island of Catan! And after many years of study, the great engineers of Catan have learned ways to improve production using this valuable new resource, both by converting it into other resources and enabling the upgrade of cities into metropolises.
Recognizing the value of making sustainability education fun and engaging, Worldwatch's Erik Assadourian has helped develop Catan: Oil Springs, a non-profit scenario for the award-winning board game that integrates a new resource into the mix—oil—and brings with it the opportunity for players to develop significantly faster, but not without risking industrial pollution and disasters such as coastal flooding triggered by climate change. Other sustainability challenges, including issues of development disparity, the resource curse, and limits to growth are integrated seamlessly into the game, where players struggle with whether they should use oil to grow even as they risk undermining the productivity of their lands and even risk inundation of the entire island of Catan.
Assadourian will be at the Goethe Institut in Washington, D.C. on March 23 to celebrate the game's release. Join us at:
Read more about Settlers of Catan: Oil Springs.


text: Porsche told us that the PDK transmission in the 2014 Porsche 911 Turbo S would take whatever abuse we threw at it. It was a perfect excuse to ask Bill Caswell to help us celebrate 50 years of Porsche with 50 consecutive launch control starts. You must see the violence to appreciate it. Read the full story right here.


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Many parents assume that frequent headaches mean their child needs glasses, so they ask their doctor to refer their child for an eye exam. This study was conducted by pediatric ophthalmologists at Albany Medical Center who wanted to find reliable answers for parents, family doctors and pediatricians facing this common health question. The research was presented at the 116th Annual Meeting of the American Academy of Ophthalmology.
In this retrospective study, which was conducted at the ophthalmology clinic of Albany Medical Center, researchers reviewed the medical records of 158 children under age 18 who were seen at the clinic for frequent headaches from 2002 to 2011. All of the children received complete eye exams by the clinic's ophthalmologists.
No significant correlation was found between their frequent headaches and a need for vision correction. The researchers reached this conclusion by comparing the results of the clinic's exams of the children with headaches to the records of their previous eye exams and other relevant medical care. Eye health and vision test results remained unchanged from earlier exams for 75 percent of the children. Also, children who already had eyeglasses were not found to need new prescriptions at the time they were seen at the clinic for headaches. Although about 14 percent of the children reported that their headaches occurred while doing visual tasks like homework, and about nine percent reported visual symptoms associated with their headaches, a need for vision correction did not appear to be the primary cause or a significant factor in any of these cases, according to the study.
The researchers considered it positive that most of the children's headaches resolved over time. Follow up reports from parents showed that headaches improved in 76.4 percent of all study subjects, including those who did and those who did not receive new vision correction prescriptions. Children who received new prescriptions were not more likely than others to have their headaches improve. Assessing the causes of the headaches and addressing the children's long-term outcomes were beyond the scope of this study.
"We hope our study will help reassure parents that in most cases their children's headaches are not related to vision or eye problems, and that most headaches will clear up in time," said Zachary Roth, M.D., of Albany Medical Center, who led the research team in conjunction with John Simon, M.D., professor and chair of pediatric ophthalmology at Albany Med. "The information should also be useful to family doctors and pediatricians in caring for children and parents who have this common health concern."
About thirty percent of the children in the study had eye conditions that went beyond the need for vision correction, including strabismus (misaligned eyes) amblyopia ("lazy eye") or other rarer, more serious conditions. Seventeen percent had a family history of migraine. Because this was a retrospective study, the researchers were unable to connect these factors with headache causes.
Sue Ford
Extension: (518) 262 – 3421


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> Home > Policy terms > Policy wording
It is advisable that you read the policy wording before you make a decision to purchase any insurance. You can view the Musicguard policy wording on this page, you also have the opportunity to download the wording before the payment page and again via a link in your email confirmation.
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Musicguard is a trading style of Thistle Insurance Services Limited. Thistle Insurance Services Limited is authorised and regulated by the Financial Conduct Authority. FRN 310419. Lloyd's Broker. Registered in England No. 00338645. Registered office: Rossington's Business Park, West Carr Road, Retford, Nottinghamshire, DN22 7SW.


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Harry Houdini is one of the world's greatest magicians/escape artist and he has a solid but little known Nova Scotia connection. My good buddy Bruce McNab spent five years or more investigating this almost lost bit of history and now has released a book. Bruce is a Red Seal Carpenter, writer, teacher and all around good guy so if you enjoy a true story, this one won't disappoint. You can still get a copy before Christmas.
Title: The Metamorphosis: The Apprenticeship of Harry Houdini


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From March 23-25, I spent a fun-filled long weekend at SingStrong. For those who don't know, SingStrong is an annual a cappella festival held in Reston, Virginia, about 20 miles away from Washington DC. The profits from SingStrong are donated to the Alzheimer's Association and also benefit local music programs. Most attendees stayed at the nearby Westin Reston Hotel, which offered very nice, well-priced accommodations. I went to SingStrong with three other members of my a cappella group from New York City, the MetropoliTones.
All day Saturday and in the morning on Sunday, a cappella experts led a variety of workshops. For example, I learned how to perform like a Rock Star from Blue Jupiter's Diana Preisler, discovered techniques for winning a cappella competitions from Jonathan Minkoff (SingStrong's producer, also from Blue Jupiter), Ben Bram and Maxx Factor (both from "The Sing-Off"), and got a crash course in recording from Dave Brown (the Mouth Off podcast) and Freddie Feldman (VOCOMOTION) at a mini A Cappella Bootcamp. Private coachings for groups were also offered during the day.
When I was not in class, I got to witness several amazing concerts throughout the weekend. SingStrong got off to an exciting start with the Friday night "ACA Idol" competition. Ten groups competed, with musical styles ranging from barbershop and folk to Top 40 and South Asian/pop fusion. The prize winners were GQ, a women's barbershop quartet. On Saturday there was a competition featuring high school groups, where the top honors were won by XIV Hours from the Durham Academy in North Carolina. But that's not all! There were also three concerts featuring several of the top pro groups in the a cappella universe. The headliners were Pentatonix, Afro Blue and Maxx Factor, all from "The Sing-Off". The concerts also featured artists with musical styles that were relatively new to me: a live-looper (Julia Easterlin), Tuvan overtone singer (Alex Glenfield), and electronic beatboxer (Masai Electro). I also enjoyed watching Blue Jupiter perform their brand new songs! It was thrilling to see such a wide range of groups and solo artists.
Another exciting addition to this year's SingStrong was the formation of the "Single Singers DC" led by Judy Fontana. Even if your entire a cappella group couldn't make it to SingStrong, you still had an opportunity to perform there with the Single Singers. Participants received their music several weeks beforehand and rehearsed together on Friday and Saturday. Their big debut was at the Saturday high school competition, where they performed five songs during the judges' deliberation. Two MetropoliTones were part of the Single Singers, and they had a great time! Unfortunately I was unable to participate, as I was sidelined by terrible allergies in the weeks leading up to SingStrong. From my spot in the audience, though, I can confirm that the Single Singers put on a wonderful, entertaining show!
A consistent theme throughout all of SingStrong was a strong sense of community. All of the classes and concerts were held in the same location (the South Lakes High School Arts Center), so it's easy to meet and mingle with other attendees throughout the day. I met everyone from the dad who came to learn how to record his young son singing a cappella, to experienced singers who have attended every SingStrong since it started in 2009. At night, Afterglow parties were held at the Westin Reston Hotel, where attendees continued to socialize and sing the night away. SingStrong also brings in many people from the local DC metro area, many of whom have probably never seen a live a cappella performance. Many of the concerts were completely sold out. There were long lines to get into the concerts, but the wait time flies by when large groups of ticket holders spontaneously break into 8-part harmony (which gave me the opportunity to practice some new beatboxing techniques I had learned earlier in the day). It was heart-warming to see so many people excited about a cappella in one place.
I can't wait for next year's SingStrong festival. I learned so much in a wonderfully supportive, friendly environment. I highly recommend SingStrong for anyone who wants to see and meet top talent, get an a cappella education and have a blast, all while supporting Alzheimer's research and local music programs.
About the author:
Carolyn Kiel has been singing and arranging a cappella music for 12 years. She got her a cappella start with the Vassar College Night Owls, where she sang bass, arranged her first song, and built the group's first website. She currently performs with the MetropoliTones, an all-women's Contemporary A Cappella League (CAL) group based in NY City. She has recorded five a cappella CDs. By day, Carolyn works in financial services technology. Her other skills include original songwriting, vocal percussion, and driving in Manhattan.


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Used 2018 JeepWrangler Unlimited Sahara 4x4 SUV
- Stock: W230
7 views in the past 7 days
- Odometer
- 6,750 miles
- Fuel Economy
- 22.0/24.0 mpg City/Hwy
- Exterior Color
- Punkn
- Interior Color
- Black
- Body/Seating
- SUV/5 seats
- Transmission
- 8 speed automatic
- Drivetrain
- four-wheel
- Engine
- 2.0L I-4 cyl
Jeep Wrangler
Highlighted Features
- Automatic temperature control
- Wireless phone connectivity
- Exterior parking camera rear
- Front dual zone A/C
- Split folding rear seat
- Remote keyless entry
- Convertible hard top
- Steering wheel mounted audio controls
Standard Specifications
Dealer Notes
2018 Jeep Wrangler Unlimited Sahara
Priced below KBB Fair Purchase Price! Odometer is 10712 miles below market average!
Priced below KBB Fair Purchase Price! Odometer is 10712 miles below market average!
KBB.com Consumer Reviews
- 4.0
Love driving my new Jeep JL Sport S 2 door
By Chuck on Friday, August 02, 2019I usually drive my 2019 GMC Sierra Crew cab. I used my play money and bought a new 2019 JL 2 door. I love this Jeep. I've had it 2 weeks and can't stay out of it. I sold the Michelin tires that came on it on craigslist and bought some Nitto GS 265/70 R17. Looks and drives great. So much fun. I got the freedom hard top. My Jeep MSRP was $36,930--I paid $31,371 or I probably wouldn't have bought it. The 2 door JL Sport S are hard to find. I feel like I got a good deal.
- 5.0
A nice jeep for all seasons
By droadrunner on Monday, June 17, 2019We went from corvettes and hi performance cars in the summer to a simple jeep convertible , it pulls a trailer, it is easy to take down the top, and we can drive it in all the rain we get here in pa . I think jeep did a great job on the new JL ,we added a set of rubicon wheels and tires , it looks great and drives nice .
- 5.0
This is a well designed Wrangler - savvy details
By Just a car guy on Friday, March 15, 2019First off, Wranglers are not for the average Joe. They are war machines originally designed and produced in a short time frame for WWII. Jeeps had one purpose: Assisting soldiers in combat areas through a multitude of carefully thought features making their mission easier. They are not practical "honey, load the kids we're going to the beach" vehicles. Most leak through the car wash. Gas mileage will always be poor due to physics. Handling has been improved but it's not a race track ready Corvette or your rich daddy's late model Benz on Michelin Pilot Sports. Wranglers have been ruined by our soft sided cupcake society and rigorous safety measures yet still score low on crash tests. (Even my newly designed 2018 JL) I've owned a couple Volvo's in my day and my wife one as a daily driver. If you are looking for comfortable seats designed by chiropractors and a top notch safety rating, buy a Volvo...they're in the business of safety. If you are looking to haul three kids buy a Yukon. If you're looking for technology buy a Tesla...man they are nice - and I will own one. If you are bored with your current American three ton truck, ugly car or minivan and need to suppress your midlife crisis cravings don't get a tattoo and buy a Harley - buy a Wrangler instead. Wranglers #1 hold their value like no other! I don't know why nor do I understand it, but they most certainly hold their value like a Toyota Tacoma or better. Wranglers are also ... FUN. They're in a class all by themselves... go topless, door less, windshield less...drive on the beach or in the woods - they are a do whatever you feel vehicle. Not to mention they're the most customized vehicle on the market. The new JL has come a long way from the Willys and CJs and are bearable to drive on longer road trips. The motors are refined and the Pentastar bugs have been worked out. I've owned three Wranglers in my day including my first car which I drove for a record six years. It was fun, unique, and a joy. People are jealous of your topless life and stare you down in the summer time. They envy the fact you can assist hung up fellow motorists in the winter time while they themselves can barely make their way up their own driveways. And whenever you're on a date trying to impress a lady friend it's always a joy to treat her to a fun, country back road and a few splashes with the top down on a nice September evening. (Oh, and don't forget the obligatory and famous Jeep wave :)
* The advertised price does not include sales tax, vehicle registration fees, other fees required by law, finance charges and any documentation charges. A negotiable administration fee, up to $115, may be added to the price of the vehicle.
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Scottish Rite Childhood Language Program
The Scottish Rite Childhood Language Program located in the Memphis medical complex, was established in 1975 by the Memphis Scottish Rite Foundation, Inc. The Scottish Rite Clinic is affiliated with the University of Tennessee, Memphis Boling Center.
The mission of the Clinic is to:
- diagnose preschool children with language disorders/delays and aid in the identification of such children through screenings
- provide speech and language therapy at a minimal cost to families
- provide parent and community education regarding childhood communication disorders
- train professionals in the area of pediatric communication disorders
Hundreds of children in the Memphis area have benefited from the identification and treatment of childhood communication disorders. With early intervention these children are much better prepared socially and academically for kindergarten.
Training Professionals
The Clinic also helps the community through its involvement in training professionals in the area of pediatric communication disorders. Each year the Clinic offers a speech/language pathology internship to a master's level speech/language pathologist. The internship provides the opportunity to work in an interdisciplinary teaching setting and to gain expertise in the professional management of pediatric speech and language disorders. The intern also gains experience in parent education and counseling. To download an application for a traineeship or fellowship, go to the Boling Center's Interdisciplinary Training Manual.
Communication Disorders
Childhood communication disorders are often first identified by a parent, family member or friend, pediatrician, or preschool teacher. The most notable signs of communication disorder include:
- speech and/or language that is distinctly different from children of the same age, gender, or ethnic group
- reluctance or inability to talk
- unsuccessful attempts to understand or to be understood by adults
For further information, contact Scottish Rite Clinic for Childhood Language Disorders, BCDD, 711 Jefferson Avenue, Memphis, TN 38105. Phone: 901-448-6511; Fax: 901-448-7097.
Contact BCDD
711 Jefferson Avenue
Memphis, Tennessee 38105
Phone: 901-448-6511
Fax: 901-448-7097


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Our Publications
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Sofa, So Good!
To kick off the 20th anniversary of one of Chicago's most important art expos, SOFA Chicago invited the scene's top names for a champagne toast. A lively designer discussion featuring top local professionals preceded the event, hosted by Interiors Chicago editor Diana Bitting.
Panelists of the discussion included Patrizio Fradiani, Dirk Lohan, Linc Thelen and Anne Coyle. VIP guests for the cocktail kickoff included fair director Donna Davies and co-founders Mark Lyman and Anne Meszko.
Attendees sipped and snacked while viewing the variety of art installations and exhibits, and the winners of the CONNECT design competition, Brooklyn-based Pratt Institute, were awarded their $2,500 prize from Chubb Insurance.


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- Consolidated Database System (CDBS) Public Searches. Find applications and EEO information filed by broadcast stations.
- For detailed instructions on using Public Access, see the User's Guide for Public Access.
- Station Search -- Information about a station.
- Application Search -- Information about a specific application or filing.
- EEO Search -- Information about broadcast, cable, and MVPD EEO filings.
- Ownership Search -- Information about station ownership structure.
- Antenna Search -- Information about standard antenna patterns.
- Application ID Number Search -- CDBS Application ID search.
- Database Download -- Download portions of the CDBS database.
- Alternatively, the detailed output options in the AM, FM, and TV Queries contain links to CDBS for individual stations and applications.
- For detailed instructions on using Public Access, see the User's Guide for Public Access.
- CDBS Electronic Filing System. Direct to account login: CDBS Account Login
- For CDBS system assistance, see the CDBS Electronic Filing User's Guide.
- List of the Broadcast Forms that MUST be electronically filed via CDBS.
Call Sign Reservation and Authorization System
- Call Sign Reservation and Authorization System (CSRS): The on-line call sign reservation and authorization system for broadcast radio and television service call signs. Apply for call signs; search for available call signs.
- For call sign system assistance, see the CSRS Users' Guide or call 202-418-2211.
Children's Television
- Children's Television: Electronically file FCC Form 2100 Schedule H and obtain information on children's television programming offered by broadcast television stations.
Electronic Filing for Cable Operators
- Cable Operations and Licensing System (COALS): Allows multi-channel video program distributors (MVPDs) and the public to view CARS licenses, registration data, and other filings held since 1994.
- List of the Cable Forms that MUST be electronically filed via COALS.
FCC Registration Number
- FRN Manager -- Associate an FRN with a Facility ID number.
Licensing and Management System (LMS)
- Licensing and Management System (LMS)
LMS is the Media Bureau's Internet based system which permits electronic filing of broadcast radio and television application forms with the FCC. LMS will eventually replaces the CDBS e-filing system. Currently Video Division services, full-power TV , Class A, Low Power Television and TV Translator stations that seek to file applications for construction permits and applications for a license to cover a construction can use LMS to file such applications. Also, all of notifications or Special temporary requests related to these stations can be filed using LMS. We will be adding more filing Schedules on an ongoing basis to LMS. For a complete list of releases visit the LMS login page and click on LMS Releases.
For more information pertaining to the Media Bureau, please call: (202) 418-7200.
Wednesday, August 21, 2019


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Back in October, I wrote a little piece on the leaked trailer for Dragonball (now re-named Dragonball Evolution) and in it I basically talked about how terrible the teaser looked. I was clearly not the only one who thought this and after 91 comments and some feuding, Screen Rant Master Vic had to shut down the thread to simmer things down.
In defense of the movie (at that time), that trailer was very early and not complete in terms of post-production. Today however, we have the first official trailer for the upcoming live-action adaptation of the hit Manga series and it still sucks… maybe even more than the first teaser.
From this trailer, the characters and costumes look ridiculous (especially the secondary characters), the fight choreography looks awful and the dialogue and cinematography has B-movie or worse written all over it. Not to mention the terrible use of slow motion in some of the action sequences.
Don't believe me? Watch and see:
Now, re-watch it while trying to put aside the special effects (which are 95% of it) and focus on what's actually happening, especially the dialogue and acting. They are burying this in heavy visual and sound effects.
It looks like they're trying so hard to take and use cool styles from other films but this movie doesn't have that kind of 'cool' and using those techniques in the wrong places with poor execution really makes this feel over-the-top but in a bad way.
What I'm seeing from the trailer and images of this film give me the exact same feeling as Catwoman and Elektra did – both of which are both on my list of worst movies ever.
Some stories simply cannot be translated to the big screen. Have you seen the characters from Dragonball Z or its action sequences? It's not even remotely human. The show was super popular and many people I know really dug it but I don't think it makes for a live-action version, especially if it's supposed to be faithful to the cartoon. Even if it's not, the extreme nature, extreme style and crazyness that was Dragonball Z (for example) can't be done in reality because it's so far from reality that it looks stupid when they try to imitate with real people. The styles are simply too different.
Even the characters saying the word "dragonball" while holding a literal glowing ball sounds and looks like cheese in live-action. And that scene with that vehicle transforming while Justin Chatwin (playing Goku) says "cool" is really awesome too... Not.
I can't tell if this is made solely for the fans of old (not me) and the young audiences or if the fans of the series' will hate this and Fox is actually targeting more of a mainstream audience.
I don't know if the movie will actually be as bad as I think this trailer is because I know Dragonball isn't my thing regardless - but I expect pretty weak box-office earnings and I know I will not see it at the theater. Like I said in my first article, it might be a fun rental. I would love to know what fans of the cartoons think of this. Do you think it can be done well in live-action? Does this meet your expectations? And for those who don't know much about Dragonball or simply may not have fancied the cartoons, will you see this flick?
Dragonball Evolution stars Justin Chatwin, James Marsters and Chow Yun-Fat and comes out April 8, 2009.


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Immuno-Augmentation With GM-CSF of Pneumococcal Vaccine in Chronic Lymphocytic Leukemia Patients
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00323557
Recruitment Status : Completed
First Posted : May 9, 2006
Results First Posted : May 2, 2012
Last Update Posted : December 5, 2012
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Drug: Sargramostim (GM-CSF) Biological: Pneumococcal Vaccine
|Phase 2
Sargramostim (also commonly called granulocyte macrophage colony stimulating factor - GM-CSF) is a medication used to stimulate the bone marrow production of white blood cells before a stem cell transplant, after chemotherapy or after a bone marrow transplant. Pneumococcal vaccine is a medication used to prevent infections caused by a bacteria called Streptococcus pneumoniae.
If you have not had a gammaglobulins test (a test to measure immunity against certain infectious diseases) measured within three months before the study begins, then this blood test will be done before you receive any study medications.
Women who are able to have children must have a negative urine pregnancy test before starting treatment.
After consenting to this study, you will be randomly assigned (as in the toss of a coin) to receive treatment with sargramostim in addition to the pneumococcal vaccine or to receive pneumococcal vaccine alone (Prevnar).
- If you are randomized to vaccine plus sargramostim group, you will receive an injection of sargramostim at the same time you receive the pneumococcal vaccine.
- If you are randomized to the vaccine alone group, you will receive the pneumococcal vaccine on the first day.
Blood tests will be performed on the day of the pneumococcal vaccination, and 4 weeks, 12 weeks and 24 weeks after vaccination. Each of the blood tests will require about 4 teaspoons of blood. These blood tests will measure your immunity to pneumococcal infection.
If after 6 months of your first vaccination your body is not able to show immunity to pneumococcal infection, you will receive a second dose either pneumococcal vaccine plus sargramostim or pneumococcal vaccine alone. Your immunity will be checked again at 4 weeks, 12 weeks, and 24 weeks after this second dose. Only 4 teaspoon of blood will be required for the tests.
You may be removed from the study if you have a severe allergic reaction to the sargramostim and/or pneumococcal vaccine. The total maximum time you will be on this is study is 24 months.
This is an investigational study. Both of the medications used in this study are approved by the FDA. Up to 50 patients may be treated on this study. All will be enrolled at M.D. Anderson.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|39 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Immuno-Augmentation With GM-CSF in Patients Receiving Pneumococcal Vaccine While Undergoing Treatment for Advanced Chronic Lymphocytic Leukemia (CLL)
|Study Start Date :
|June 2004
|Actual Primary Completion Date :
|May 2011
|Actual Study Completion Date :
|May 2011
Experimental: Pneumococcal Vaccine + GM-CSF
Vaccine subcutaneously + GM-CSF (3 Doses of 250 mg subcutaneously) given either Pre Vaccine at Day -7, Day -1 and Day 0 (day of pneumococcal vaccine) or Post Vaccine given at Day 0, Day +3 and Day +7.
Drug: Sargramostim (GM-CSF)
Starting with 3 doses of 250 micrograms subcutaneously, either pre or post vaccine. For pre vaccine, GM-CSF on days -7 (+ 1 day) and -3 (+ 1 day), in the week prior to vaccination for pre-vaccination immune priming; 3rd dose on the day of vaccination (day 0); and for post-vaccine GM-CSF given simultaneously on day of vaccination (day 0) and 2 more doses Day +3 and Day +7 after pneumococcal vaccine.
Other Names:
Experimental: Pneumococcal Vaccine Alone
First vaccine dose subcutaneously, Day 0.
Biological: Pneumococcal Vaccine
Subcutaneously on Day 0
Other Name: Prevnar
- Number of Participants (With Increase) Immune Response to GM-CSF With a Pneumococcal Vaccine [ Time Frame: Baseline and at 1 month after vaccine. ]Response defined as 2-fold rise in anticapsular immunoglobulin G (IgG) when prevaccination titer is compared with levels post vaccination and with a final level of >0.5 ug/mL. Anti-pneumococcal immunoglobulin titers measured at baseline and 1 month after vaccine. Response determined by measuring serum IgG to capsular polysaccharides from 6 of the most common infecting serotypes of Streptococcus pneumoniae.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|Child, Adult, Older Adult
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
1) Patients in complete / partial remission or those with active Chronic lymphocytic leukemia (CLL) with Rai stage 0 to 4.
Exclusion Criteria:
- Patients will not be entered while neutropenic (PMNs < 500 cells/mm3) or having received Rituximab within 6 months.
- Patients will not be entered while febrile (Temperature > 38 degrees C) within 1 week.
- Active infection.
- Patients with known Human immunodeficiency virus (HIV) infection.
- Known history of allergy to Granulocyte/ macrophage colony stimulating factor (GM-CSF) or pneumococcal vaccine.
- Chemotherapy other than Campath, fludarabine, cyclophosphamide, in 4 weeks.
- Patients who have previously received pneumococcal vaccine within the preceding 12 months.
- Absolute lymphocyte count less than 500 cells/mm3.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00323557
|United States, Texas
|UT MD Anderson Cancer Center
|Houston, Texas, United States, 77030
|Principal Investigator:
|Amar Safdar, MD
|M.D. Anderson Cancer Center
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|M.D. Anderson Cancer Center
|ClinicalTrials.gov Identifier:
|NCT00323557 History of Changes
|Other Study ID Numbers:
|First Posted:
|May 9, 2006 Key Record Dates
|Results First Posted:
|May 2, 2012
|Last Update Posted:
|December 5, 2012
|Last Verified:
|December 2012
Chronic Lymphocytic Leukemia
Pneumococcal Pneumonia
Pneumococcal Vaccine
Leukemia, Lymphoid
Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, B-Cell
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Heptavalent Pneumococcal Conjugate Vaccine
Immunologic Factors
Physiological Effects of Drugs