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Miele Rotary Iron
With its contemporary design and easy-to-use temperature selection dial, this user-friendly rotary iron features a 34 1/2"-wide roller that presses large table and bed linens and garments to a crisp professional finish just like an old-fashioned laundry mangle.
- With our rotary iron you can press a large tablecloth, duvet cover or a stack of napkins in less than 4 minutes.
- The iron's open-end design easily accommodates shirts and extra-wide linens.
- Easy-to-use foot pedal, allows you to sit comfortably as you guide items through the top roller and heating plate.
- Adjustable roller speed to suit the type of laundry being pressed or your preferred working rate.
- Pressed laundry folds neatly onto a shelf underneath.
- Swing-out bar provides additional space to hang finished items.
- Three temperature settings.
- Safety features include a finger guard and an emergency release button.
- Folds vertically (2.4 sq. ft.) and wheels away for easy, compact storage.
- Arrives fully assembled.
Dimensions & More Info
- Model # B990.
- 39 1/2" x 16 1/2" x 37" high (19 1/2" x 16 1/2" x 41 3/4" high when closed).
- 34 1/2"-wide roller.
- 84 lb.
- This product is intended for use in the United States and Canada and is built to United States electrical standards.
- Made in Germany.
Shipping Information
This item will be shipped directly from the manufacturer and is not eligible for rush shipping. Please allow one to two weeks for delivery.
Shipping Rates
The shipping rate varies depending on your order total and shipping destination. View Shipping Options and Charges.
Return Policy
At Williams Sonoma, we take great pride in the quality and craftsmanship of our products. Attention to design, materials, safety and construction are our priority. Upon receipt, please inspect your purchase and notify us of any damage; we will arrange for a prompt replacement.
If within 30 days, you are dissatisfied for any reason, you may return your purchase for a refund of the merchandise value. An original receipt or gift receipt is required for all returns and exchanges. Returns with a gift receipt will be refunded in the form of a Merchandise Credit for the amount indicated on the gift receipt. Returns with original receipt will be refunded in the original form of payment, cash and check refunds over $100 will be issued as a company check (may take 14 business days from time of request).
For all cutlery returns (knife sets, single knives, cutting boards, knife sharpeners, and knife storage) please contact us at 888.922.4108 to initiate the return.
We cannot accept returns on monogrammed, personalized, special-order items, custom upholstery, food, items shipped direct from the vendor, or on items damaged through normal wear and tear. Final sale items ending in .97 or .99 cannot be returned.
For returns of items purchased from your Williams Sonoma Gift Registry, we will gladly provide a refund or exchange for the merchandise within 90 days of your event or within 90 days of purchase, whichever date is later. View Full Returns Policy.
Miele Rotary Iron
|Delivery Surcharge
|Miele Rotary Iron


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subset: commoncrawl


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In Morton, Bucs have reliable presence in rotation
DUNEDIN, Fla. -- In reviewing the Pirates' 2013 season, pundits frequently identify the arrival of Gerrit Cole as a flash point, citing the impact of his addition to the pitching staff.
Deserved praise, to be sure, but an inadvertent slight of Charlie Morton, the veteran right-hander who merged into the rotation at the same time and with the same results.View Full Game Coverage
DUNEDIN, Fla. -- In reviewing the Pirates' 2013 season, pundits frequently identify the arrival of Gerrit Cole as a flash point, citing the impact of his addition to the pitching staff.
Deserved praise, to be sure, but an inadvertent slight of Charlie Morton, the veteran right-hander who merged into the rotation at the same time and with the same results.View Full Game Coverage
Morton, after fully recovering from Tommy John surgery, made his first start on June 13, two days after Cole's big league debut. The Bucs went 12-7 in starts by Cole, who fashioned an ERA of 3.22, and 12-8 in starts by Morton, whose ERA was 3.26.
So Morton obviously provided the same midseason jolt to the playoff-bound Pirates.
"Hopefully I helped the team," Morton said. "If not, they need to find somebody else who will."
The Pirates like who they have now, just fine. As evidence, the club in December signed Morton to a three-year deal for $21 million. General manager Neal Huntington had given a contract of that length to only one other pitcher, Ian Snell in March 2008.
The security presented by that deal is contributing to the ideal Spring Training being enjoyed by the 30-year-old Morton. In two starts and five innings, he has allowed two baserunners, one on a hit and the other on a walk. Those two starts match the combined total Morton had in 2012, when he was recovering from hip surgery, and in '13, when he was still rehabbing from the Tommy John procedure.
So both physical and financial health are letting him prepare for the season with a clear mind.
"It's an aspect of a career," Morton said of the peace he has found through the contract. "When you set out on a career path, one of your goals is to make money, to take care of your family. So it's a load off my back. But it's not the only reason I play; not even close to being the main motivation.
"Yet it absolutely helps focus attention to other things, like getting the job done -- instead of feeling your back is always against the wall, and telling yourself that the time you did put into baseball didn't pay off."
A big part of the reason it did pay off is Morton's money pitch. The sinker is not exalted as one of baseball's hammers, not like a 98-mph two-seamer or a split-fingered fastball that dives under a swing. A sinker is recognized as a "contact" pitch that earns a pitcher a nickname such as "Ground Chuck."
Coming out of Morton's hand, the sinker can be lethal. Neil Walker, who gets to see it from the perfect vantage point of second base, calls Morton "one of the nastiest guys in all of baseball when he is on, his ball has so much movement."
Morton has been able to throw his best sinker early in Spring Training, to both his satisfaction and surprise, because it usually takes a while to get a feel for the pitch.
"It's been nice to have it early," said Morton, who prides himself in throwing a sinker with multiple dimensions. "What makes it good is I'm not just manipulating the ball down in the zone, I'm also trying to throw it hard. I might reach back and try to throw it by somebody."
On the average, Morton will throw that sinker about 60 percent of the time, making it one of those pitches batters might anticipate but still can't hit -- especially right-handed batters, when Morton is giving it to them low and inside.
"That's usually when my sinker is best, when I can throw it arm-side down and in," Morton said.
In 2011, he allowed one home run in 381 at-bats to a right-handed hitter. Conversely, in 2012, he knew there was something seriously wrong with his elbow when he couldn't command that tough sinker and let righties take him deep five times in only 100 at-bats. Last season, he reduced that yield to three homers in 247 at-bats.
A pitcher's work is never done, and Morton's next phase is trying to tame left-handed hitters. He knows what he has to do to give them a better fight.
"Front-door sinkers [on the outside corner] ... that's what I need to do to be effective against lefties," Morton said, "because they hit, what, .370 ... maybe .400, maybe .500 ... off me? Seems like that, at least."
Of course, it wasn't that fat. But a lifetime left-handed opponents' average of .327, with an OPS of .904, is fat enough.
Morton is working on that, because not facing the hook when an opposing lefty steps into the batter's box in a key midgame situation is one way to improve his chances of working more innings than his modest career high of 171 2/3, in 2011.
Something else the mid-2013 arrivals share: Morton and Cole, in the rotation out of the gate, should cover most of the 191 innings gone with workhorse A.J. Burnett.
Although, Morton would advise against approaching it like that.
"Focusing on not having A.J. here is a useless thought," he said. "Saying 'we got to make this up' distracts from what you should be trying to do. We might as well talk about anybody else who is not here. We're here, so we got to get it done for ourselves, not to make up for someone else."
Tom Singer is a reporter for MLB.com and writes an MLBlog Change for a Nickel. He can also be found on Twitter @Tom_Singer.


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Critics scores range from 0 to 100, with higher scores indicating more favorable reviews.
out of 100
Metascore®Mixed or average reviewsbased on a weighted average of allcritic review scores.
Last Action Hero makes such a strenuous show of winking at the audience (and itself) that it seems to be celebrating nothing so much as its own awfulness. In a sense, the movie's incipient commercial failure completes it aesthetically.
Read Full Review
Last Action Hero is sporadically entertaining, but it could have been a whole lot more. Trimmed down and better edited, this film might have been a top-notch satire. As it is, however, it gets caught someplace in between action and comedy, and never really comes across as a solid example of either.
This movie-within-a-movie action-comedy spoof is a too long, too loud tease as it toys with the Schwarzen-dude's well-toned cinematic image. [18 Jun 1993, p.1D]
For all of its sensational stunts and flashes of wit, however, Last Action Hero plays more like a bright idea than like a movie that was thought through. It doesn't evoke the mystery of the barrier between audience and screen the way Woody Allen did, and a lot of the time it simply seems to be standing around commenting on itself.
The stunt work and special effects are top flight; Schwarzenegger and the kid are just fine, but we can't help but want this film to stop kidding around and thrill us. [18 Jun 1993, p.C]
See all Last Action Hero reviews at Metacritic.com
Iffy for 13+
Arnold spoofs action movies, adds more violence.
What Parents Need to Know
Parents need to know that this spoof/critique of action films has itself an excessive amount of violence, explosions, and killings. While kids may love this, the sheer number of people who are killed or plotted to be killed (at least 15) make it too much for younger kids. Jack's son is killed and daughter kidnapped, and Danny nearly dies as well. Jack is shot and nearly dies, bubbling up blood from his mouth. Also, several characters smoke.
Messages: Lots of sociopathic behavior here, including stealing cars, killing people, plotting to blow people up.
Violence: Excessive violence with plenty of gun shots, explosions, punches, and kicks. Nerve gas is used and people fall through glass skylights. Jack's son is pushed off a building and falls to his death. Jack is shot in the chest and nearly dies; He coughs blood. Danny is held captive and pushed over a building, nearly dying. Jack's daughter is kidnapped and slapped. A body flies through a windshield. Someone is electrocuted.
Sex: Jack mentions premature ejaculation. Models in lingerie, including thongs, run around. Ashley kisses Danny. A prostitute offers herself to Benedict.
Language: Some salty language, including "hell," "damn," "goddamn," "smart ass," "asshole," "s--t," and "f--k."
Consumerism: The film is a commercial for other action stars and films, including Sylvester Stallone, E.T., Basic Instinct, Terminator, etc.
Drinking, drugs and smoking: Jack smokes cigars. People talk about cocaine and crack houses. Several other characters smoke cigarettes.
An independent nonprofit dedicated to providing families the information they need to help kids thrive in a world of media and technology.
© Common Sense Media Inc. 2010. All rights reserved.
Movies.com, the ultimate source for everything movies, is your destination for new movie trailers, reviews, photos, times, tickets + more! Stay in the know with the latest movie news and cast interviews at Movies.com.
Copyright © 2019 FANDANGO MOVIES.


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Production Operators are at the centre of Shell's oil and gas production business. Around the world, our people can be found working in day-to-day oil and gas production operations in assets of one of our Operating Units. This also includes the commissioning and start-up of our new oil and gas developments. Our people provide support to new projects and field development planning to ensure safe and optimal operability of our future facilities.
As a Production Operator you will be working in one or more of the following areas of expertise: field operations, programming (short term optimisation of production volumes), integrated activity planning (to optimise cross discipline activities and resources), hydrocarbon information management or real time operations.


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The genesis of Modern Outdoor comes from a fabricator of fine furniture and fixtures for retail and residential spaces with 20+ years of experience. Modern Outdoor fills a niche here in America for quality, modern outdoor furniture that satisfies even the most discerning clientele. Our products are equally suited for residential, restaurants, hospitality, and all manner of public spaces.
Luma is impressive visually, as well as functionally. Clean-lined, precision machined, solid aluminum components are joined with exposed, inset stain less steel hardware to create a geometrically inspired line. With its base structure of recycled content aluminum that is milled, grained and marine-grade anodized, Luma is the perfect solution for coastal environments. Luma is a full breadth line with dining, bar height, lounge, cafe and pool setting pieces included.
All Modern Outdoor furniture ships fully assembled using blanket-wrapped, white-glove delivery.
|Anodized Aluminum and Polyboard or Ipe Wood frame.
34w x 34l x 10.25h
34w x 54l x 10.25h
34w x 60l x 10.25h
34w x 72l x 10.25h
34w x 84l x 10.25h
54w x 54l x 10.25h
54w x 60l x 10.25h
54w x 72l x 10.25h
54w x 84l x 10.25h
Current selection:
|Catalog ID
|Reference ID
Ships via 2Modern Standard Delivery.
Have a question about this product? Need help finding something? Our expert Customer Service team is here to help. Give us a call at (888) 222-4410 or email us.


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Item #: kb-sunsetsea
Sunset at Sea Giclee
All prints fit standard frames, allowing the self-framing option. 8x10 (image size 5x7), 11x14 (image size 6x9), 16x20 (image size 10x14) 18x24 (image size 12x18) and 24x36 (image size 20x32). The first four sizes have an attractive light gray mat printed around the image. The 24x36 (Poster size) on paper, has 2" of white border around the image.
All prints are digitally signed and titled by the artist.
Each giclee is an individually printed, high-resolution, high-fidelity image done on a special large format printer, produced from Ken's digital photo files.
Giclees are superior to traditional lithography in several ways. The colors are brighter, last longer, and are so high-resolution that they are virtually continuous tone, rather than tiny dots. The range, or "gamut" of color for giclees is far beyond that of lithography, and details are crisper.
Magnificently detailed and wonderfully decorative, these are museum quality images on paper and canvas. The giclees of Ken Buckner create a whole new vibrant medium for art.
Ships in 5-7 business days.
Not eligible for return or exchange. Please view our return policy for more information. Ships UPS or USPS ground.


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Your turn! Move like a piece on a giant game board through three centuries of American games, puzzles, and public amusements at Game Time! located on The Strong's second floor. Feast your eyes on oversized toy props; see rare, historic treasures from The Strong's game and puzzle collections; and jump right in for active hands-on family fun.
- Conquer the maze in a jumbo Perplexus, designed especially for The Strong, and compare it to the 1889 original handheld ball maze Pigs in Clover that President Benjamin Harrison was known to enjoy.
- Check out oversized versions of Connect Four, Rush Hour, and Battleship; and a flashing, electronic, big-screen toy bingo.
- Challenge yourself to a gaggle of games including Jenga, air hockey, dome hockey, paper football, pinball, word search games, tangrams, puzzles, and dominoes.
- Trace the history of board-, card-, and role-playing games through a multimedia timeline showcasing historic artifacts, photographs, advertisements, and videos.
- See rare artifacts on view for a limited time, including Síochán leat (the Irish Game), a one-of-its-kind game designed by Brenda Romero to explore the 17th-century invasion of Ireland; and the Dalluhn Manuscript, a text believed by some experts to be the earliest existing version of Dungeons & Dragons.
View Game Time! fun facts.
GameTime! is produced by The Strong.
Game Time! is made possible in part by the Mary Valentine and Andrew Cosman Trusts.
The project is made possible by a grant from
The Strong acknowledges the support of Greater Hudson Heritage Network for artifact preservation.


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Mike DeRosa Receives Prestigious Award At VFW National Convention
The Burger King Franchise Operator with the Big Heart has spurred his restaurants and fellow franchise operators on to raise over 2.6-million dollars for VFW's Unmet Needs Program. Continue reading
Governor Walker, WDVA Kick-off Commemoration of 50th Anniversary of Vietnam War
President Barack Obama has proclaimed May 28, 2012 through November 11, 2025 as the Commemoration of the 50th Anniversary of the Vietnam War. Continue reading
Bachmann Removes VA Budget Cut Suggestion
WASHINGTON, D.C., February 4, 2011 — Rep. Michele Bachmann (R-Minn.) posted a statement on her congressional website today that she would remove from consideration a $4.5 billion suggestion that would have affected payments made to disabled veterans. Continue reading
VFW Will Defeat Bachmann Plan
COMRADES AND SISTERS: This is important that we all become pro-active, contact your U.S. Representative and U.S. Senator concerning no cuts to America's Veterans
VFW Announces Legislative Priorities for 2011
As a new decade begins, VFW is more determined than ever to fight for key veterans' issues.
"We've set some fierce objectives in this year's Priority Goals, and we're determined to see it through for our veterans," explained Raymond Kelley, VFW Legislative Director. "But we need a lot of support to get the job done." Continue reading
January-February 2011 CheckPoint Magazine
Follow the link to read Checkpoint Continue reading


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Lilac Comforters Amazing Pictures #4 Lilac Comforter Sets Queen Best 25 Lavender Bedding Ideas On Pinterest Bedrooms 6
Home » Comforter » Lilac Comforters » Lilac Comforters Amazing Pictures #4 Lilac Comforter Sets Queen Best 25 Lavender Bedding Ideas On Pinterest Bedrooms 6
12 photos of Lilac Comforters Amazing Pictures #4 Lilac Comforter Sets Queen Best 25 Lavender Bedding Ideas On Pinterest Bedrooms 6
Lilacli•lac (lī′lək, -läk, -lak),USA pronunciation n.
- any of various shrubs belonging to the genus Syringa, of the olive family, as S. vulgaris, having large clusters of fragrant purple or white flowers: the state flower of New Hampshire.
- pale reddish purple.
- having the color lilac.
Comforterscom•fort•er (kum′fər tər),USA pronunciation n.
- a person or thing that comforts.
- a quilt.
- a long, woolen scarf, usually knitted.
- the Comforter. See Holy Ghost.
Picturespic•ture (pik′chər),USA pronunciation n., v., -tured, -tur•ing.
- a visual representation of a person, object, or scene, as a painting, drawing, photograph, etc.: I carry a picture of my grandchild in my wallet.
- any visible image, however produced: pictures reflected in a pool of water.
- a mental image: a clear picture of how he had looked that day.
- a particular image or reality as portrayed in an account or description;
- a tableau, as in theatrical representation.
- See motion picture.
- pictures, Informal (older use). movies.
- a person, thing, group, or scene regarded as resembling a work of pictorial art in beauty, fineness of appearance, etc.: She was a picture in her new blue dress.
- the image or perfect likeness of someone else: He is the picture of his father.
- a visible or concrete embodiment of some quality or condition: the picture of health.
- a situation or set of circumstances: the economic picture.
- the image on a computer monitor, the viewing screen of a television set, or a motion-picture screen.
pic′tur•a•ble, adj.
- to represent in a picture or pictorially, as by painting or drawing.
- to form a mental picture of;
imagine: He couldn't picture himself doing such a thing.
- to depict in words;
describe graphically: He pictured Rome so vividly that you half-believed you were there.
- to present or create as a setting;
portray: His book pictured the world of the future.
pic′tur•a•ble•ness, n.
pic′tur•a•bly, adv.
pic′tur•er, n.
Lilacli•lac (lī′lək, -läk, -lak),USA pronunciation n.
- any of various shrubs belonging to the genus Syringa, of the olive family, as S. vulgaris, having large clusters of fragrant purple or white flowers: the state flower of New Hampshire.
- pale reddish purple.
- having the color lilac.
Comfortercom•fort•er (kum′fər tər),USA pronunciation n.
- a person or thing that comforts.
- a quilt.
- a long, woolen scarf, usually knitted.
- the Comforter. See Holy Ghost.
Setsset (set),USA pronunciation v., set, set•ting, n., adj., interj.
- to put (something or someone) in a particular place: to set a vase on a table.
- to place in a particular position or posture: Set the baby on his feet.
- to place in some relation to something or someone: We set a supervisor over the new workers.
- to put into some condition: to set a house on fire.
- to put or apply: to set fire to a house.
- to put in the proper position: to set a chair back on its feet.
- to put in the proper or desired order or condition for use: to set a trap.
- to distribute or arrange china, silver, etc., for use on (a table): to set the table for dinner.
- to place (the hair, esp. when wet) on rollers, in clips, or the like, so that the hair will assume a particular style.
- to put (a price or value) upon something: He set $7500 as the right amount for the car. The teacher sets a high value on neatness.
- to fix the value of at a certain amount or rate;
value: He set the car at $500. She sets neatness at a high value.
- to post, station, or appoint for the purpose of performing some duty: to set spies on a person.
- to determine or fix definitely: to set a time limit.
- to resolve or decide upon: to set a wedding date.
- to cause to pass into a given state or condition: to set one's mind at rest; to set a prisoner free.
- to direct or settle resolutely or wishfully: to set one's mind to a task.
- to present as a model;
place before others as a standard: to set a good example.
- to establish for others to follow: to set a fast pace.
- to prescribe or assign, as a task.
- to adjust (a mechanism) so as to control its performance.
- to adjust the hands of (a clock or watch) according to a certain standard: I always set my watch by the clock in the library.
- to adjust (a timer, alarm of a clock, etc.) so as to sound when desired: He set the alarm for seven o'clock.
- to fix or mount (a gem or the like) in a frame or setting.
- to ornament or stud with gems or the like: a bracelet set with pearls.
- to cause to sit;
seat: to set a child in a highchair.
- to put (a hen) on eggs to hatch them.
- to place (eggs) under a hen or in an incubator for hatching.
- to place or plant firmly: to set a flagpole in concrete.
- to put into a fixed, rigid, or settled state, as the face, muscles, etc.
- to fix at a given point or calibration: to set the dial on an oven; to set a micrometer.
- to tighten (often fol. by up): to set nuts well up.
- to cause to take a particular direction: to set one's course to the south.
- to put (a broken or dislocated bone) back in position.
- (of a hunting dog) to indicate the position of (game) by standing stiffly and pointing with the muzzle.
- to fit, as words to music.
- to arrange for musical performance.
- to arrange (music) for certain voices or instruments.
- [Theat.]
- to arrange the scenery, properties, lights, etc., on (a stage) for an act or scene.
- to prepare (a scene) for dramatic performance.
- to spread and secure (a sail) so as to catch the wind.
- [Print.]
- to arrange (type) in the order required for printing.
- to put together types corresponding to (copy);
compose in type: to set an article.
- [Baking.]to put aside (a substance to which yeast has been added) in order that it may rise.
- to change into curd: to set milk with rennet.
- to cause (glue, mortar, or the like) to become fixed or hard.
- to urge, goad, or encourage to attack: to set the hounds on a trespasser.
- [Bridge.]to cause (the opposing partnership or their contract) to fall short: We set them two tricks at four spades. Only perfect defense could set four spades.
- to affix or apply, as by stamping: The king set his seal to the decree.
- to fix or engage (a fishhook) firmly into the jaws of a fish by pulling hard on the line once the fish has taken the bait.
- to sharpen or put a keen edge on (a blade, knife, razor, etc.) by honing or grinding.
- to fix the length, width, and shape of (yarn, fabric, etc.).
- [Carpentry.]to sink (a nail head) with a nail set.
- to bend or form to the proper shape, as a saw tooth or a spring.
- to bend the teeth of (a saw) outward from the blade alternately on both sides in order to make a cut wider than the blade itself.
- to pass below the horizon;
sink: The sun sets early in winter.
- to decline;
- to assume a fixed or rigid state, as the countenance or the muscles.
- (of the hair) to be placed temporarily on rollers, in clips, or the like, in order to assume a particular style: Long hair sets more easily than short hair.
- to become firm, solid, or permanent, as mortar, glue, cement, or a dye, due to drying or physical or chemical change.
- to sit on eggs to hatch them, as a hen.
- to hang or fit, as clothes.
- to begin to move;
start (usually fol. by forth, out, off, etc.).
- (of a flower's ovary) to develop into a fruit.
- (of a hunting dog) to indicate the position of game.
- to have a certain direction or course, as a wind, current, or the like.
- (of a sail) to be spread so as to catch the wind.
- (of type) to occupy a certain width: This copy sets to forty picas.
- [Nonstandard.]sit: Come in and set a spell.
- set about:
- to begin on;
- to undertake;
- to assault;
- set against:
- to cause to be hostile or antagonistic.
- to compare or contrast: The advantages must be set against the disadvantages.
- set ahead, to set to a later setting or time: Set your clocks ahead one hour.
- set apart:
- to reserve for a particular purpose.
- to cause to be noticed;
distinguish: Her bright red hair sets her apart from her sisters.
- set aside:
- to put to one side;
reserve: The clerk set aside the silver brooch for me.
- to dismiss from the mind;
- to prevail over;
annul: to set aside a verdict.
- set back:
- to hinder;
- to turn the hands of (a watch or clock) to show an earlier time: When your plane gets to California, set your watch back two hours.
- to reduce to a lower setting: Set back the thermostat before you go to bed.
- set by, to save or keep for future use.
- set down:
- to write or to copy or record in writing or printing.
- to consider;
estimate: to set someone down as a fool.
- to attribute;
ascribe: to set a failure down to bad planning.
- to put in a position of rest on a level surface.
- to humble or humiliate.
- to land an airplane: We set down in a heavy fog.
- (in horse racing) to suspend (a jockey) from competition because of some offense or infraction of the rules.
- set forth:
- to give an account of;
describe: He set forth his theory in a scholarly report.
- to begin a journey;
start: Columbus set forth with three small ships.
- set forward, to turn the hands of (a watch or clock) to show a later time: When your plane lands in New York, set your watch forward two hours.
- set in:
- to begin to prevail;
arrive: Darkness set in.
- (of winds or currents) to blow or flow toward the shore.
- set off:
- to cause to become ignited or to explode.
- to begin;
- to intensify or improve by contrast.
- to begin a journey or trip;
- set on:
- Also, set upon. to attack or cause to attack: to set one's dog on a stranger.
- to instigate;
incite: to set a crew to mutiny.
- set one's face against. See face (def. 35).
- set out:
- to begin a journey or course: to set out for home.
- to undertake;
attempt: He set out to prove his point.
- to design;
plan: to set out a pattern.
- to define;
describe: to set out one's arguments.
- to plant: to set out petunias and pansies.
- to lay out (the plan of a building) in actual size at the site.
- to lay out (a building member or the like) in actual size.
- set store by. See store (def. 9).
- set to:
- to make a vigorous effort;
apply oneself to work;
- to begin to fight;
- set up:
- to put upright;
- to put into a high or powerful position.
- to construct;
- to be assembled or made ready for use: exercise equipment that sets up in a jiffy.
- to inaugurate;
- to enable to begin in business;
provide with means.
- to make a gift of;
treat, as to drinks.
- to stimulate;
- to propound;
- to bring about;
- to become firm or hard, as a glue or cement: a paint that sets up within five minutes.
- to lead or lure into a dangerous, detrimental, or embarrassing situation, as by deceitful prearrangement or connivance.
- to entrap or frame, as an innocent person in a crime or a criminal suspect in a culpable circumstance in order to achieve an arrest.
- to arrange the murder or execution of: His partner set him up with the mob.
- [Bridge.]to establish (a suit): to set up spades.
- the act or state of setting or the state of being set.
- a collection of articles designed for use together: a set of china; a chess set.
- a collection, each member of which is adapted for a special use in a particular operation: a set of golf clubs; a set of carving knives.
- a number, group, or combination of things of similar nature, design, or function: a set of ideas.
- a series of volumes by one author, about one subject, etc.
- a number, company, or group of persons associated by common interests, occupations, conventions, or status: a set of murderous thieves; the smart set.
- the fit, as of an article of clothing: the set of his coat.
- fixed direction, bent, or inclination: The set of his mind was obvious.
- bearing or carriage: the set of one's shoulders.
- the assumption of a fixed, rigid, or hard state, as by mortar or glue.
- the arrangement of the hair in a particular style: How much does the beauty parlor charge for a shampoo and set?
- a plate for holding a tool or die.
- an apparatus for receiving radio or television programs;
- [Philately.]a group of stamps that form a complete series.
- [Tennis.]a unit of a match, consisting of a group of not fewer than six games with a margin of at least two games between the winner and loser: He won the match in straight sets of 6–3, 6–4, 6–4.
- a construction representing a place or scene in which the action takes place in a stage, motion-picture, or television production.
- [Mach.]
- the bending out of the points of alternate teeth of a saw in opposite directions.
- a permanent deformation or displacement of an object or part.
- a tool for giving a certain form to something, as a saw tooth.
- a chisel having a wide blade for dividing bricks.
- [Hort.]a young plant, or a slip, tuber, or the like, suitable for planting.
- [Dancing.]
- the number of couples required to execute a quadrille or the like.
- a series of movements or figures that make up a quadrille or the like.
- a group of pieces played by a band, as in a night club, and followed by an intermission.
- the period during which these pieces are played.
- [Bridge.]a failure to take the number of tricks specified by one's contract: Our being vulnerable made the set even more costly.
- [Naut.]
- the direction of a wind, current, etc.
- the form or arrangement of the sails, spars, etc., of a vessel.
- suit (def. 12).
- [Psychol.]a temporary state of an organism characterized by a readiness to respond to certain stimuli in a specific way.
- a timber frame bracing or supporting the walls or roof of a shaft or stope.
- [Carpentry.]See nail set.
- a collection of objects or elements classed together.
- the width of a body of type.
- sett (def. 3).
- fixed or prescribed beforehand: a set time; set rules.
- specified;
fixed: The hall holds a set number of people.
- deliberately composed;
customary: set phrases.
- fixed;
rigid: a set smile.
- resolved or determined;
habitually or stubbornly fixed: to be set in one's opinions.
- completely prepared;
ready: Is everyone set?
- all set, in readiness;
prepared: They were at the starting line and all set to begin.
Also, get set!
- (in calling the start of a race): Ready! Set! Go!
Queenqueen (kwēn),USA pronunciation n.
- a female sovereign or monarch.
- the wife or consort of a king.
- a woman, or something personified as a woman, that is foremost or preeminent in any respect: a movie queen; a beauty queen; Athens, the queen of the Aegean.
- (disparaging and offensive).
- a male homosexual, esp. one who is flamboyantly campy.
- See drag queen.
- a playing card bearing a picture of a queen.
- the most powerful piece of either color, moved across any number of empty squares in any direction.
- [Entomol.]a fertile female ant, bee, termite, or wasp.
- a word formerly used in communications to represent the letter Q.
queen′less, adj.
- to reign as queen.
- to behave in an imperious or pretentious manner (usually fol. by it).
- to become promoted to a queen.
queen′like′, adj.
Bestbest (best),USA pronunciation adj., [superl. of]good [with]better [as compar.]
- of the highest quality, excellence, or standing: the best work; the best students.
- most advantageous, suitable, or desirable: the best way.
- largest;
most: the best part of a day.
adv., [superl. of]well [with]better [as compar.]
- most excellently or suitably;
with most advantage or success: an opera role that best suits her voice.
- in or to the highest degree;
most fully (usually used in combination): best-suited; best-known; best-loved.
- as best one can, in the best way possible under the circumstances: We tried to smooth over the disagreement as best we could.
- had best, would be wisest or most reasonable to;
ought to: You had best phone your mother to tell her where you are going.
- something or someone that is best: They always demand and get the best. The best of us can make mistakes.
- a person's finest clothing: It's important that you wear your best.
- a person's most agreeable or desirable emotional state (often prec. by at).
- a person's highest degree of competence, inspiration, etc. (often prec. by at).
- the highest quality to be found in a given activity or category of things (often prec. by at): cabinetmaking at its best.
- the best effort that a person, group, or thing can make: Their best fell far short of excellence.
- a person's best wishes or kindest regards: Please give my best to your father.
- all for the best, for the good as the final result;
to an ultimate advantage: At the time it was hard to realize how it could be all for the best.Also, for the best.
- at best, under the most favorable circumstances: You may expect to be treated civilly, at best.
- get or have the best of:
- to gain the advantage over.
- to defeat;
subdue: His arthritis gets the best of him from time to time.
- make the best of, to cope with in the best way possible: to make the best of a bad situation.
- with the best, on a par with the most capable: He can play bridge with the best.
- to get the better of;
beat: He easily bested his opponent in hand-to-hand combat. She bested me in the argument.
Beddingbed•ding (bed′ing),USA pronunciation n.
- blankets, sheets, etc., used on a bed;
- bedclothes together with a matress.
- litter;
straw, etc., as a bed for animals.
- a foundation or bottom layer.
- a thin layer of putty laid in the rabbet of a window frame or muntin to give a pane of glass an even backing.
- arrangement of sedimentary rocks in strata.
- [Hort.]of or pertaining to a plant esp. suited to or prepared for planting in an open-air bed for ornamental displays: bedding hyacinths; bedding begonias.
Ideasi•de•a (ī dē′ə, ī dēə′),USA pronunciation n.
i•de′a•less, adj.
- any conception existing in the mind as a result of mental understanding, awareness, or activity.
- a thought, conception, or notion: That is an excellent idea.
- an impression: He gave me a general idea of how he plans to run the department.
- an opinion, view, or belief: His ideas on raising children are certainly strange.
- a plan of action;
an intention: the idea of becoming an engineer.
- a groundless supposition;
- a concept developed by the mind.
- a conception of what is desirable or ought to be;
- (cap.) [Platonism.]Also called form. an archetype or pattern of which the individual objects in any natural class are imperfect copies and from which they derive their being.
- [Kantianism.]See idea of pure reason.
- a theme, phrase, or figure.
- [Obs.]
- a likeness.
- a mental image.
Onon (on, ôn),USA pronunciation prep.
- so as to be or remain supported by or suspended from: Put your package down on the table; Hang your coat on the hook.
- so as to be attached to or unified with: Hang the picture on the wall. Paste the label on the package.
- so as to be a covering or wrapping for: Put the blanket on the baby. Put aluminum foil on the lamb chops before freezing them.
- in connection, association, or cooperation with;
as a part or element of: to serve on a jury.
- so as to be a supporting part, base, backing, etc., of: a painting on canvas; mounted on cardboard; legs on a chair.
- (used to indicate place, location, situation, etc.): a scar on the face; the book on the table; a house on 19th Street.
- (used to indicate immediate proximity): a house on the lake; to border on absurdity.
- in the direction of: on the left; to sail on a southerly course.
- (used to indicate a means of conveyance or a means of supporting or supplying movement): on the wing; This car runs on electricity. Can you walk on your hands? I'll be there on the noon plane.
- by the agency or means of: drunk on wine; talking on the phone; I saw it on television.
- in addition to: millions on millions of stars.
- with respect or regard to (used to indicate the object of an action directed against or toward): Let's play a joke on him. Write a critical essay on Shakespeare.
- in a state or condition of;
in the process of: on strike; The house is on fire!
- subject to: a doctor on call.
- engaged in or involved with: He's on the second chapter now.
- (used to indicate a source or a person or thing that serves as a source or agent): a duty on imported goods; She depends on her friends for encouragement.
- (used to indicate a basis or ground): on my word of honor; The movie is based on the book.
- (used to indicate risk or liability): on pain of death.
- (used to indicate progress toward or completion of an objective): We completed the project on budget.
- assigned to or occupied with;
operating: Who's on the switchboard this afternoon?
- [Informal.]so as to disturb or affect adversely: My hair dryer broke on me.
- paid for by, esp. as a treat or gift: Dinner is on me.
- taking or using as a prescribed measure, cure, or the like: The doctor had her on a low-salt diet.
- regularly taking or addicted to: He was on drugs for two years.
- with;
carried by: I have no money on me.
- (used to indicate time or occasion): on Sunday; We demand cash on delivery.
- (used to indicate the object or end of motion): to march on the capital.
- (used to indicate the object or end of action, thought, desire, etc.): to gaze on a scene.
- (used to indicate subject, reference, or respect): views on public matters.
- (used to indicate an encounter): The pickpocket crept up on a victim.
- on the bow, [Naut.]bow3 (def. 7).
- in, into, or onto a position of being supported or attached: Sew the buttons on.
- in, into, or onto a position of covering or wrapping: Put your raincoat on.
- fast to a thing, as for support: Hold on!
- toward a place, point, activity, or object: to look on while others work.
- forward, onward, or along, as in any course or process: further on.
- with continuous activity: to work on.
- into or in active operation or performance: Turn the gas on.
- on and off, off (def. 22a).
- on and on, at great length, so as to become tiresome: They rambled on and on about their grandchildren.
- operating or in use: The television set was on. Is your brake on?
- taking place;
occurring: Don't you know there's a war on?
- performing or broadcasting: The radio announcer told us we were on.
- behaving in a theatrical, lively, or ingratiating way: Around close friends, one doesn't have to be on every minute.
- functioning or performing at one's best: When she's on, no other tennis player is half as good.
- scheduled or planned: Anything on after supper?
- [Baseball.]positioned on a base or bases: They had two men on when he hit the home run.
- [Cricket.]noting that side of the wicket, or of the field, on which the batsman stands.
- on to, aware of the true nature, motive, or meaning of: I'm on to your little game.
- [Cricket.]the on side.
Harold, born 1930, English playwright.
Bedroomsbed•room (bed′ro̅o̅m′, -rŏŏm′),USA pronunciation n.
- a room furnished and used for sleeping.
- concerned mainly with love affairs or sex: The movie is a typical bedroom comedy.
- sexually inviting;
amorous: bedroom eyes.
- inhabited largely by commuters: a bedroom community.
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PC and Mac Accessories
Transformers USB drive
Manufacturer: Takara
Price: $44.99 (Shop.ars)
What has claws, teeth, glowing red eyes, and 2GB of storage? Ravage, the Decepticon USB drive (Megan Fox not included). You could fit a tiny Linux distro on this thing, and still have space left over for pirated anime... and if you actually did that, you would be such an epic nerd that we could come up behind you, slip our hands under the elastic wasteband at the back of your jeans, grab your underoos, and give you a huge wedgie. Really, just put quarterly reports on it or something—it's already a Transformers USB drive, so there's no need to overdo it.
Anyway, all of us here at the Ars Orbiting HQ are huge Transformers fans, which is why this gets our vote for Best. USB drive. Ever. You'd better hurry and get yours, because they'll probably be out of stock soon.
R2-D2 USB Humidifier
Manufacturer: Taito
Price: $20.90 (Shop.ars)
What would a gift guide be without at least one Star Wars item? Celebrate one of the two real protagonists of the trilogy (the other being C-3PO) with this USB-powered humidifier. It doesn't project holograms, open cargo bay doors, or eject light sabers from its top, but it does feature "wicking action" for vaporizing up to 8 ounces of water and keeping the air in your office as moist as the swamps of Dagobah.
HyperMac external MacBook/MacBook Pro/MacBook Air battery
Manufacturer: HyperMac
Price: $199.50 (Shop.ars)
With Apple swiftly moving away from user-replaceable batteries in its laptop line, travelers may feel stuck without an easy battery backup when on the road or during lengthy meetings. The solution we like for this problem is from HyperMac, which offers external batteries of varying capacities that can be plugged into your Mac notebook via the traditional MagSafe connector, just as if you were plugging your laptop into a power outlet.
The batteries range from 60 watt-hours to 222 watt-hours, and are compatible with all models of MacBook Pro, MacBook Air, and MacBook. They can even be used to charge iPhones, BlackBerrys, Kindles, and other USB devices. Needless to say, we want one of these to help get us through our coverage of live Apple events.
Manufacturer: chromatic bytes
Price: $90.00 (Shop.ars)
Canvas users were forced out of their comfort zone last year when, in the face of growing sales of Apple computers, the parent company discontinued the Mac version of the popular drawing tool. The obvious alternative is Illustrator, but some of us can't tolerate the cost and bloat of Adobe products, not to mention that there have been some issues with Snow Leopard compatibility and Adobe's Creative Suite.
ZeusDraw is a great alternative, and $90 is a small price to pay for a polished application. There's definitely a learning curve, and it doesn't always do everything you want in quite the manner you expect, but it's more than capable of churning out solid illustrations.
Twelve South BookArc Stand for Notebooks
Price: $49.99 (Shop.ars)
If you're using your laptop with a large monitor and would rather rock a retro mini-tower look than turn the laptop's screen into a second monitor, then the BookArc laptop stand is for you. The BookArc is aimed at MacBook and MacBook Pro users, and in truth, that's probably a wise choice of target demographic for this idea, because the Mac user base contains the highest concentration of people who are willing to sacrifice the utility of a second monitor for the aesthetics of a space-age-looking desk-side PC. The BookArc is truly a triumph of form over function, but we love it nonetheless.
Wacom Bamboo Multitouch tablet
Price: $99.00 (Shop.ars)
Wacom's newest family of tablets aims to bring multitouch to those of us who want to use this input method with our desktop PCs. Unfortunately, it largely fails. So why are we recommending it? Because as an entry-level pen tablet it's a fantastic offering—it takes the combination of features and low price that have made the Bamboo Fun popular with graphic design dabblers and adds in a few improvements. Plus, you can use it to do two-finger scrolling, which is the gesture that works the best on this thing. So while Wacom's latest may still leave us waiting on an external touchpad that's truly comparable to the MacBook's built-in trackpad, it's nonetheless the leader in low-priced pen input.


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Barry Gordemer
Barry Gordemer is an award-winning writer and producer and director for NPR's Morning Edition. He's helped produce and direct NPR coverage of two Persian Gulf wars, five presidential elections, the Sept. 11 terrorist attacks, and hurricane Katrina. He's also produced numerous profiles of actors, musicians, and writers.
His career in radio spans more than 25 years, beginning at NPR member station WFAE in Charlotte North Carolina, and including stops at Minnesota Public Radio and A Prairie Home Companion.
In 2000, Barry received special recognition from the George Foster Peabody Awards for his long-time service to Morning Edition.
Barry also is the founder of Handemonium, a company that designs and creates puppets for television and film. In 2003, Barry received a Telly award for his puppet designs and his performance as Alphie the Alligator on the DVD series, "The Sound and the Furry."
In 2000, Barry performed on the CD Dreamosauraus. It received a Grammy nomination for "Best Musical Album for Kids."


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|Pattern: Nola Cloche by Hilary Smith Callis Yarn: Supernova in colorway Pewter by Luna Grey Fiber Arts
eucalan. i like the lavender scent. i am also a fan of soak and cannot wait to try our sponsor quince and co's new lanolin soap! it sounds heavenly! it's on my "to try" list this year. i've got a thing for always trying out new rinses for my knits. what's your current fave?
you all know how important i think blocking is. it's a pain - yes...it sort of goes hand in hand with swatching. they are both necessary evils. they are kind of boring and we all are too excited to want to do them most of the time but i promise you that if you block (if appropriate for your project) the outcome is soooo worth it. trust me on that one. if you'd like to know a bit more about blocking here are two great post from my lovely friend rebecca of "nook":
- blocking from summer sweater knig along 2012
- blocking party from summer sweater knit along 2011
i cannot wait to wear that brim! i'm mostly a slouch hat kinda gal so i'm looking forward to branching out a bit into the cloche style. should be fun! i'm watching it dry as we speak and am crossing my fingers it's on my head by late this afternoon :) i only wished i had been able to indulge in a nice soak myself last night with some tea and downton abbey. i would have cried more than my tub could hold bath water though. i know a lot of you ladies have been commiserating in the ravelry group and i'm right there with ya. only issue for me is that i have seen the whole season and i'm still crying. so if i chat too much about it i'll give it all away. just be reminded to buy stock in kleenex. you're gonna need it.
oh and in case you're wondering what that lovely tea print fabric is under my hat it's from the lovely bari j and it's called "tea delights jam" from splendor 1920 for art gallery fabrics. i luuuurve it! you may remember i used some of it in a different colorway in my christmas tree skirt this december.
ravelry group so i can show off your lovely finished projects in our "starring you" post soon! i can't wait to see them! there are some gorgeous ones in there already and a lot of you are on your 2nd projects for the kal! go ladies go!
so grab your tea and come sip and chat with me. i want to hear about what YOU thought about this past weekends episode and how your project is doing.
you can follow along with all things downton abbey knit along here:


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Dr. Zhivan Alach
Dr. Zhivan Alach is currently employed by a New Zealand security agency. Previously, he was an analyst for the New Zealand Defence Force. A longer version of this monograph was published in Defence Studies, Vol.10, Issues 1 and 2, March 2010. Dr. Alach holds a Ph.D. in defence policy from the University of Auckland.
*The above information may not be current. It was current at the time when the individual worked for SSI or was published by SSI.
SSI books and monographs by Dr. Zhivan Alach
The New Aztecs: Ritual and Restraint in Contemporary Western Military Operations
July 08, 2011
Authored by Dr. Zhivan Alach.
The Western way of war has come full circle. After centuries, indeed millennia, of evolution toward increased totality and brutality, it has turned back once again to the ritualistic and restrained methods of primitive warfare.
Slowing Military Change
October 29, 2008
Authored by Dr. Zhivan Alach.
The author revises, reexamines, and reevaluates the contemporary military environment. He finds that the environment is a period of relative military stasis, of slow technological development, and of little novelty in broader issues. If anything, it is a return to an older period, of the time before the Cold War, before the fear of nuclear war dominated all other thinking in the field.


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A Life Threatening Warm-up
I sit in a parking lot with a student and watch a woman drive circles around our parked car. She loops repeatedly in a big black truck, flashing a peace sign and shouting "You can do it Matt, you can do it!!" She's pumping her son up for his Mock Driving Exam. At one point Matt throws his half-eaten apple at her. It's a perfect shot through her window, but Mom dodges her head just in time. She shakes a fist in the air and keeps circling.
I really like the mom and Matt. This is only our second time together, but we have a rapport that occasionally occurs between strangers. The first time I met Matt's mom she looked at me with a serious, concerned-parent expression and said, "So what's in today's lesson, lawn jobs and taking out mailboxes?"
Matt and I laugh as Mom does another loop around our car. A faint odor of burnt tire is building as the truck show continues. Matt turns and looks at me.
"Ya' know, she recently survived breast cancer. She's much different now, in a good way."
It's amazing what a life-threatening incident can do to your perspective on living. The heaviness attached to "major events" seems to dissipate and then fade away. I watch with a smile as Mom finishes her circling and speeds off, her big truck hurtling out of the parking lot.
We break from the outside entertainment and get down to business. I run Matt through the initial, pre-drive setup.
"Mirrors?" I say, knowing that kids rarely bother to check these.
"Check!" Matt replies, sounding like a fighter pilot.
Matt tips his head back and polishes off a big can of Red Bull. I keep pace, powering down a huge cup of corrosive 7-Eleven coffee. During our last lesson Matt revealed that he has ADD, but it didn't seem to affect his concentration that much. After that admission I was expecting a sketchy session with jerky turns and bad lane changes, but Matt proved to be quite safe and vigilant.
"Okay," I say, "This is a Mock Exam. I'm only giving directions here. You're in charge. Ready?"
Matt nods, looks through the windshield, and says, "Let's do this thing."
We pull out of the parking lot and drive down a main road.
"Okay," I say, "Let's take a left at the next light."
Matt drifts into the turn lane. A minivan swinging through the intersection cuts the turn too sharply and starts heading straight at us.
Matt laughs and says, "Wrong lane buddy" before hitting his brake. The stranger keeps driving straight at us. He gets to within thirty feet of our car before realizing his error. Startled, he whips his head to the side and yanks the wheel, swerving back onto his side of the road. The minivan snakes back and forth through two over-corrections before the driver regains control. He drives past us, looking dazed.
Matt and I laugh in unison. It's a fairly close call but Matt handled it perfectly.
"Good," I say, "you played it cautious. And you didn't honk. Nice job."
We roll through the intersection and enter a busy four-lane road. Approaching a solid green light, I tell Matt to turn left when it's safe. Since the light is solid, and not a green arrow, we need to yield. Matt taps the brakes and we begin slowing. Without warning he suddenly hits the gas and turns the steering wheel.
What the …?
We're in the middle of the intersection before I can react. I whip my head to the side and see two cars bearing down on us from the other direction. The closest, a mid-sized sedan, lurches to a halt. Its hood presses down violently and snaps back up as the driver blares the horn. The second, a huge black SUV with its grill at head level, actually speeds up. For a split second, time stops and I feel like I'm standing frozen while a train barrels at me. The truck is twenty feet from my open window and I hear the roar of its engine as my stomach falls away.
"Go, go, go, go, go!!!" I scream.
Matt slams on the gas. Our heads snap back and we rocket into a dead-end road.
Matt pulls to the curb and we sit silently for a moment. My heart's pounding and my head feels fuzzy. I picture medics dragging my body out of the car with the Dodge Ram insignia pressed into my forehead. The truck looked just like the one Matt's mom was driving; I'm tempted to ask him if this is her idea of a joke.
The pounding slows and my head starts to clear. I chuckle and look over at Matt, our eyes meeting. I know he's as shaken as I am, and his sheepish look says he's probably expecting me to shout at him. But I never yell at kids. That's not what a teacher does, regardless of how frustrated they might be.
"You might want to give yourself a bit more room there," I say calmly.
Matt exhales and shakes his head. "Man," he says, "you've got nerves of steel."
"Well, think of it this way," I reply, "you'll never forget to yield on a solid green again. I can guarantee that."
We continue on as if nothing happened. Technically, he failed the test, so I could just terminate the lesson and plod back to the school in a dejected haze. But that wouldn't accomplish anything. I still want my student to benefit from our drive, and after dodging a flaming wreck I'm sure he learned something today. That's all that really matters.
I give Matt one more try at an unprotected left turn, and he does it perfectly this time.
"Okay," I say, "we'll just consider that other turn to be a life-threatening warm-up."


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LOS ANGELES (Reuters) - A pneumonia outbreak is threatening hundreds of bighorn sheep in California's Mojave National Preserve, and wildlife officials said Monday they see no promising options for saving the state's biggest herd or protecting a nearby population in Nevada.
The disease is believed to have killed 20 bighorn sheep during the past month in the 1.6-million-acre (650,000-hectare) desert preserve, which lies 50 miles southwest of Las Vegas, National Park Service spokeswoman Linda Slater said.
"I suspect that many more are infected," Slater said, adding that the entire herd, numbering as many as 300 animals, is in danger. "The biologists seem to be very pessimistic."
Potential options under consideration include shooting some or all of the remaining members of the herd in a bid to prevent further spread of the disease, or continuing to monitor the situation and essentially let nature run its course, wildlife officials said.
"There really are no good options," Slater said.
Episodic waves of disease have thinned bighorn herds for years. Fewer than 100,000 sheep are believed to roam the rugged mountain slopes of the West today, compared with an estimated 1.2 million head that inhabited the region at one time.
A series of nine separate outbreaks across five western states, including Nevada, in the winter of 2009-2010 claimed roughly 1,000 bighorn sheep, prized as game animals for the prominent curled horns of the adult males, or rams.
The current outbreak is the most severe ever to hit the desert species of bighorn sheep in California, home to 5,200 head in roughly 60 herds across the state, said Steve Torres, a supervisor for the California Fish and Wildlife Department's investigations lab.
It was also the first to hit the Mojave National Preserve since it was established in 1994.
The infected bighorn herd, one of five groups in the Mojave preserve, is a "foundation" herd and one of California's healthiest, used to re-establish the species in other parts of the state, officials said. It also is the state's largest.
Tests have confirmed that at least five of the animals on Old Dad Mountain died from a strain of pneumonia carried by domestic sheep and goats that is usually fatal when transmitted to bighorn sheep, which have no natural defenses to the disease.
Nevada wildlife officials worry the disease could spread to their state's nearest herd, just 45 miles to the northeast, especially now that rutting season is beginning and males are known to wander as far as 100 miles from home.
But Nevada officials are hoping that an extreme hot spell in the forecast will tend to keep young rams close to their familiar water sources.
California's wildlife investigator Torres said another big jump in infections within the herd could come with the start of mating season next month.
Additional reporting by Laila Kearney; Editing by Lisa Shumaker


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When a Hotel becomes
your House
Travel. Discover. Wanderlust.
Vienna House is all about the joy of travelling, adventure and discovery.
We're authentic hosts – and it shows. Just like a visit with friends, if not better.
Comfort. Discovery. Experience.
Vienna House is a modern hotel experience with an understanding of what's important: the simple beauty of life. High-speed Internet meets attentive service, unique local experiences and exclusive interior design. All topped with a helping of Viennese charm.


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(To be fair, Eugene Rivers works both sides of the aise)
WASHINGTON – From a sparsely adorned office building a stone's throw from the White House, Joshua DuBois carefully navigates the delicate line between church and state.
Each morning, he sends a devotional message to President Obama's BlackBerry. He appears before religious and community groups to explain his role as director of the White House Office of Faith-based and Neighborhood Partnerships and, in turn, relays their concerns to administration officials. In the course of any given day, he'll receive as many as 750 emails from religious leaders, reporters, and government officials.
But in all the political juggling, the 26-year-old preacher's kid remains a person of faith who quotes from favorite hymns – "Come, Thou Fount of Every Blessing" is one. The Bible, too, serves as inspiration.
"I'm often inspired by the grass-roots nature of Acts and the early church," he said recently in an interview, "and what they were able to build from virtually nothing."
A distinct contrast
To some extent, DuBois is doing just that with the faith-based office, which Obama inherited from former President George W. Bush, but revamped in a bid to expand its focus, depoliticize the grant-making process, and tamp down church-state concerns.
DuBois, a veteran of Obama's Senate office who oversaw religious outreach for his presidential campaign, is a distinct contrast from the Republican appointees who preceded him, including the policy wonk John DiIulio, who opened the office in 2001, or Jim Towey, a former lawyer for Mother Teresa, or the cerebral Jay Hein.
Raised in the African Methodist Episcopal Church by his mother and stepfather, a minister in Nashville, Tenn., DuBois became an associate pastor of Calvary Praise and Worship Center, a small, African-American Pentecostal church in Cambridge, Mass., while an undergraduate at Boston University.
"I am very clear about the fact that I am a committed Christian and my faith is important to me; it's a central part of my life," he said. "At the same time, I am now in a role in this office … to reach out to Americans of all different religious backgrounds and folks who don't adhere to a particular religion."
In Washington, DuBois attends a nondenominational church that worships in a rented movie theater. He still maintains ties to the Cambridge church and to Boston, where he worked with the National TenPoint Leadership Foundation, which encouraged black churches to aid at-risk, inner-city youth.
"Josh was very serious and very smart and was very concerned … as an undergraduate in trying to connect faith to issues of public policy," said Eugene Rivers, a co-founder of the foundation and a prominent black Pentecostal leader.
In a May interview with radio host Krista Tippett in St. Paul, Minn., DuBois talked about his awakening in 1999 when New York police officers were acquitted in the shooting death of unarmed African immigrant Amadou Diallo.
"It shook in me a sense that I needed to connect to something larger, to understand all the nuances in the world, both in terms of politics and also in terms of religion," he told Tippett's "Speaking of Faith" program.
"So that's when I found my church and my faith and also started my political path as well."
That political path is taking shape as his office helps craft Obama's key speeches on religion – Catholicism at the University of Notre Dame, Islam at Cairo University, for example. His office also works with various federal agencies on issues ranging from disaster preparation to the upcoming 2010 census.
Though he doesn't dwell on his relative youth, he said he realizes the weighty responsibilities given to someone who hasn't even reached 30 yet. "I think one of the most important things is to know what you don't know," he said.
In his talks to various religious groups, DuBois outlines the office's four-point focus on economic recovery, abortion reduction, responsible fatherhood, and interfaith relations. He's met with evangelicals, Jews, Hindus, and Sikhs, as well as secularists who think his office shouldn't exist.
Religious leaders, including members of the office's advisory council, say DuBois, like the president, is a good listener who seeks to find common ground among disparate viewpoints.
Leah Daughtry, a Pentecostal minister who until recently was the chief of staff at the Democratic National Committee, sees DuBois' Pentecostal background informing his work.
"The kind of work that he's doing in reaching out to people across political spectrums, across ideological perspectives, across theological perspectives, really can only be done if you're Spirit-led," she said. "Because it's the same spirit of Christ that sought to reach beyond the confines of his own people."
While DuBois' day job is heading up the faith-based office, he also carries another title: special assistant to the president, which includes the daily presidential meditations as well as helping the first family find a church home in Washington.
Some people who have known DuBois say his workload can cause him to be disorganized and unresponsive, although they declined to have their names attached publicly to their criticisms. For his part, DuBois says he's doing the best he can.
"We're a federal entity that's coordinating 11 offices with pretty key priorities. … I try to be as responsive as I can, along with my staff and others here at the White House. But there are always going to be some challenges in that regard."
Daughtry joked that DuBois – who finds time to be a Big Brother to a Boston teenager and keep up a five-year relationship with his girlfriend – has made a bargain of sorts with God to manage his busy schedule.
"He's attached to that cell phone like it's another appendage," she said. "I'm convinced he's got some deal with God to give him a couple of extra hours a day."
(The seeds of this "many paths to heaven" religious inclusivism/pluralism are being sown into Pentecostalism through politics in this generation just as Billy Graham did the same among Baptists and evangelicals in the prior one, and as it was done in other movements i.e. the mainline denominations earlier in the last century. We Christians must watch and pray. By the way, we Reformed Christians shouldn't be so quick to point fingers, as the Reformed/Calvinist state churches practically invented inclusivism, unitarianism, universalism and other forms of theological liberalism, and liberal Episcopals, Presbyterians etc. have long been religious pluralists. The Pentecostals are just following the older and more established Christian movements down the path which may lead to one world religion and one world government.)


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Sunday, July 1, 2012
Potential treatment target identified in an animal model of pancreatic cancer
Analyzing circulating tumor cells reveals signaling pathway that may be essential to spread of deadly tumor
Detailed analysis of genes expressed in circulating tumor cells (CTCs) – cells that break off from solid tumors and travel through the bloodstream – has identified a potential treatment target in metastatic pancreatic cancer. In a report that will appear in Nature and has received advance online publication, Massachusetts General Hospital (MGH) Cancer Center investigators describe finding increased expression of WNT2, a member of a known family of oncogenes, in CTCs from a mouse model of the deadly tumor and from human patients. The researchers were able to capture the CTCs –present in the bloodstream at extremely low levels – using a microchip-based device previously developed by members of the team.
"This proof of principle study is the first to show that, by studying both mouse and human pancreatic cancer cells captured with this device, we can dissect genes that are overexpressed in these cells and identify signaling pathways that allow them to survive in the bloodstream," says Daniel Haber, MD, PhD, director of the MGH Cancer Center and senior author of the Nature paper. "We also found that targeting a key step in these pathways can reduce metastatic potential, which is critically important for control of pancreatic cancer. This study would not have been possible without a way to isolate rare CTCs from both mouse models and human patients."
Using the second-generation version of the CTC-chip, developed in collaboration with the MGH Center for Engineering in Medicine, the researchers first captured CTCs from mice genetically programmed to develop pancreatic cancer, one of the most deadly tumors since it is rarely diagnosed before spreading. Analysis of RNA expression levels in pancreatic CTCs, in primary tumor cells, and in normal pancreatic tissue identified several genes with significantly increased expression in the CTCs. One of these, WNT2, belongs to a family of developmental genes often overexpressed in cancer, and while the gene's expression in pancreatic tumors was higher than in normal tissue, WNT2 expression was significantly more elevated in both CTCs and metastatic cells.
Closer analysis of cells from several individual animals confirmed that WNT2 was highly expressed in pancreatic cancer CTCs and in metastases, but WNT2-expressing cells were found to be rare in primary tumors. Testing the consequences of WNT2 expression indicated that cancer cells expressing the gene were more likely to generate metastases, probably because of an improved ability to survive after dislodging from the primary tumor and entering the bloodstream.
The researchers tested several agents known to inhibit the activity of molecules in the WNT2 pathway their results implied was associated with pancreatic cancer and found that inhibition of TGF-beta activated kinase 1 (TAK1) prevented metastasis-associated activities in cultured CTCs. Knocking down TAK1 expression with RNA interference also reduced the development of metastasis in mice injected with WNT2-expressing CTCs. A significant percentage of tested CTCs from patients with metastatic pancreatic cancer were found to express WNT-related genes, along with other components of the signaling pathway associated with pancreatic cancer in the mouse model.
"The picture in more complicated in humans, since multiple WNTs are upregulated," Haber says. "But the TAK1 inhibitor we tested appears to have an effect on diverse WNT pathways involved in the survival of pancreatic CTCs. We previously reported that TAK1 inhibition has promise for treating a genetically defined subset of colon cancers, and these findings now extend the relevance of the TAK1 pathway to suppression of blood-borne metastasis in pancreatic cancer. Considerable more work will be needed to fully understand the critical pathways involved, but it is our hope that TAK1 inhibitors will ultimately be developed for clinical testing."
Haber is the Kurt Isselbacher/Peter Schwartz Professor of Oncology at Harvard Medical School and a Howard Hughes Medical Institute investigator. Co-lead authors of the Nature report are Min Yu, PhD, and David Ting, MD, PhD, MGH Cancer Center. Additional co-authors include Shyamala Maheswaran, PhD, Ben Wittner, PhD, Sridhar Ramaswamy, MD, Nabeel Bardeesy, PhD, and Lecia Sequist, MD, MGH Cancer Center; and Shannon Stott, PhD, and Mehmet Toner, PhD, MGH Center for Engineering in Medicine. The study was supported by grants from Stand Up to Cancer, the Howard Hughes Medical Institute, the National Institute of Biomedical Imaging and Bioengineering, the National Institutes of Health, the Pancreatic Cancer Action Network and the Warshaw Institute for Pancreatic Cancer Research.
Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $750 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, reproductive biology, systems biology, transplantation biology and photomedicine.
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For our industry issue, ASBMB Today asked three of its members who work in industry— Weiping Jiang, Matthew Olson and Anthony S. Serianni— to answer questions about themselves and their research
How long have you been an ASBMB member?
I've been a member since 1992.What do you study?
I study enzymes for the development of products, including proteins, antibodies and assay kits.Why did you go into industry?
To generate new research tools to advance our understanding of health and disease.
How do you feel ASBMB could best help scientists in industry?
The society could foster more interactions among the scientists in industry as well as between scientists from both industry and academia.
Where do you see research in industry going in five to 10 years?
I think there will be a focus on increased sensitivity and specificity of detection tools.
Has the downturn in the economy affected your job or your company?
Do you think your academic training prepared you for working in industry?
How do you think research in academia differs most from research in industry?
Research in academia is hypothesis-driven. Research in industry is utility-driven.
Next profile >> Matthew Olson
How long have you been an ASBMB member?
I've been a member since 2002.
What do you study?
I'm part of a team engaged in the development of cell-free and cell-based assays, which take advantage of label-free detection technology to monitor the enzymatic and biophysical properties of enzymes and proteins with their appropriate substrates and ligands. My role is to provide complete kinetic characterization of enzymes and evaluate signal transduction systems using substrates/effectors that are as "in vivo-like" as possible. Then, I determine the ability of small molecule antagonists and agonists to modulate these macromolecular systems.
Why did you go into industry?I received a job offer from Wyeth Pharmaceuticals during my second postdoctoral fellowship. My wife and I considered other options at the time, but we made the decision to go to Pearl River, N.Y., where I joined the infectious disease department.
How do you feel ASBMB could best help scientists in industry?Partnership and synergy.
There is a need for industry and academics to partner. Industry needs academic innovation. Academia needs industry to develop that innovation for drug discovery. Combined, they will create jobs for young scientists to carry the baton passed to them in both fields. ASBMB already is playing a major role in bridge building between academics and industry by using their current platforms: LIPIDMAPS, PSI, the ASBMB journals and the Experimental Biology meeting as a whole.
Where do you see research in industry going in five to 10 years?
Personalized medicine has been given much fanfare in recent years. This very well may be the future because there is a need for drug development taking genetic differences into account. Other areas gaining popularity in the coming years may be epigenetics and stem cells. These technologies are being evaluated for intervention of cancer and metabolic diseases. Another topic which may make resurgence is anti-infective drug discovery.
Has the downturn in the economy affected your job or your company?
The easy answer is, "What industry has not been affected?" All industries have been under pressure to increase efficacy. I think the more relevant issues affecting my job and the pharmaceutical industry as a whole are monitoring patent expirations, halting patent infringement and producing a robust pipeline. Although patent expirations are a given, rule updating could help. On the other hand, patent infringement is an undesirable reality with unpredictable consequences resulting in significant revenue losses translated into the research and development of an organization. R&D assets protected by patents are linked closely to current corporate profits. Often, unknown to the general public, is the fact that my industry reinvests up to 40 percent of its profits into R&D for a robust pipeline. Therefore, any unpredicted loss in revenue due to infringement undoubtedly will translate into budget reorganization and affect the future pipeline. Without a pipeline, we can't exist.
Do you think your academic training prepared you for working in industry?
Yes. I was well trained by my thesis advisor and now mentor, Laurie Kaguni. Further academic training involved postdoctoral fellowships with Charles McHenry and Rafael Fridman. With Rafi, I also was privileged to work with Shahriar Mobashery. Because of their partnership in basic science pursuits, I learned the value and importance of being part of a team: "To go fast, you go alone. To go far, you go together."
(Olson Continued)
Success in my journey, academics and industry, did not come merely from being under someone's tutelage. First, I sought out mentors. Regardless of their awareness, I found people I wanted to emulate. Because coping with failure is never easy, it was from these very people that I gathered insights regarding my failures, thus leading to downstream success. Second, I adopted the mindset of "Yes, I will." It is my opinion that passion cannot be taught. But, it can be caught. Third, I learned how to have vision and be provisional with help from my mentors. They taught me the importance of seeing beyond the here and now and then figuring out how to get there.
How do you think research in academia differs most from research in industry?
Differences between academics and industry: the number of projects, timelines, obligations, goals and objectives.
The sheer volume of failures involved in taking a drug to clinic requires multiple projects to run in parallel. Otherwise, to run in series is too great a time expense.
Likewise, timelines in industry are short. In many pharma and biotech operations, projects must show at least the promise of progressing to clinic within 18 months of project initiation. This means target validation, complete assay development, HTS campaign, initial HIT evaluation, valid cell-based assays and animal models in place and the initiation of lead development.
Many think of the above points as the "industrialized mindset" of drug discovery and science. In certain respects, this is correct. However, industry must, and does, have the infrastructure to support such campaigns. The business of drug discovery is, by its very nature, high-risk and high-reward. Regardless, we have obligations to our shareholders. They expect a return on their investment and we are obligated to deliver. In academics, many researchers focus on a particular topic or topic set for years, decades or an entire career. This is a timeline that is not affordable in industry. This does not mean that these career-long endeavors do not have value. They do. They're just different. I hold many academic scientists in high regard because they take the time to dissect the important nuances of a particular enzyme, cell pathway, signal transduction mechanism or set of enzymes. Their work is foundational. Industry needs academics to lead in this way.
In industry, our goals and objectives necessitate tracking multiple targets, as our success is not based solely upon the pursuit of evaluating the target itself, but finding the appropriate modulator of that target. The biggest hurdle in drug discovery is not determining the enzyme's mechanism or the mechanism for describing the modulator of that enzyme. It is avoiding toxicity – off-target effects. To take a new molecular entity to the FDA, you must show the small or large therapeutic molecule is specific, nontoxic and cleared by the body and that the compound's metabolites are not toxic and have minimal side effects.
Next profile >> Anthony S. Serianni
How long have you been an ASBMB member?
For more than 15 years.
What do you study?
I am a structural glycobiologist. I am interested in developing new NMR-based tools to investigate the structures of simple and complex carbohydrates in solution. We aim to apply these new tools to improve our understanding of the chemical and biochemical properties of saccharides.
Why did you go into industry?
I co-founded Omicron Biochemicals Inc. in 1982, a few months before I accepted a faculty position at the University of Notre Dame. The company was started because, during my graduate studies at Michigan State University, we had developed new chemical methods to introduce stable isotopes site-specifically into saccharides that allowed access to a much greater array of labeled sugars than was accessible previously. This improved capability led to a number of requests for labeled compounds from the research community. As I was intent on pursuing an academic research career, I solved the problem by starting a small company during my postdoctoral stay at Cornell University to satisfy the needs of the research community, thinking at the time that this company would last perhaps three to five years. The company still is in operation 28 years later.
How do you feel ASBMB could best help scientists in industry?By supporting basic discovery in the life sciences through which new applied technologies will be born. ASBMB should be a home for, and an advocate of, the discovery of core scientific knowledge. It should embrace fundamental inquiry as the agent that spurs new practical solutions. Industrial scientists need access to new, radical ideas and findings on a continuing basis to develop new ways to solve contemporary problems. Industrial scientists frequently do not have the time or money to pursue basic research – they largely are product-driven and thus depend on the academic community in great measure to supply the fundamental knowledge from which practical solutions can be developed.
Where do you see research in industry going in five to 10 years?
I know better than to predict the future. But, we are experiencing a time of significant change in both academic and industrial research. There is not enough space here to explain why this is occurring, but one factor is that the public is becoming more aware of the fact that, after more than 60 years of relatively generous federal research funding in the U.S., there still are major deficiencies in our ability to solve old and persistent problems, especially in the health-related areas. This partly may explain the shift in academic scientific research to solving practical, real-world problems. It is hard to say how long this trend will continue. In due course, however, a proper balance between basic and applied research needs to be struck, otherwise the discovery of fundamental, disruptive technologies that change the course of research, and our world, could be compromised. We need liberal minds thinking about lofty problems and people solving current problems with current technologies. Applied science without its basic research partner to support, stimulate and nourish it, is a formula for mediocrity and stagnation in the long term.
Has the downturn in the economy affected your job or your company?
As my main job is as a professor at the University of Notre Dame, the downturn has had a minimal impact, apart from perhaps reducing my pay raises in recent years! Federal research funding for academic research also has become more challenging in recent years. At Omicron, we largely have been immune to past economic downturns, which largely were limited to the U.S. This is because our clients are worldwide, and we are not dependent on U.S. clients for a large percentage of our sales. In the recent downturn, however, being global in nature, the situation may be different, especially if the downturn persists. Over the past 12-18 months, the effect has been small. What happens over the coming 12-18 months will depend on how well the global economy recovers, and how well governments, foundations and the private sector are willing or able to invest in chemical and biological research.
Do you think your academic training prepared you for working in industry?
Only partly so. I was trained to think about scientific research in a very personal way. That is, fundamental research was paramount. As long as the work had a strong focus, addressed core questions, had realistic long-term objectives and was rigorous, then it did not matter whether it had an immediate application. In fact, this research philosophy led to the core discoveries that gave rise to Omicron. We were not looking to start a company; instead, as a result of basic, curiosity-driven study, we uncovered procedures that represented, at that time, disruptive technology with regard to saccharide labeling. In the business world, however, serving the needs of the client is paramount, thus fundamental research must be balanced with solving practical problems. Making money is the end-game in business, if your aim is to sustain a business over the long term. I had to learn this lesson and abide by these rules when operating Omicron.
How do you think research in academia differs most from research in industry?
The answer to this question depends on the historical time frame, and on the specific environments in academia and industry under scrutiny. I perceive academic research, perhaps naively so, as a venue for pursuing new and risky ideas, a place where researchers are not fettered by the need to generate a saleable product in the short term for public consumption and revenue generation, as is the case in most industrial settings. It is a privilege to be able to work in such a manner, that is, to be sustained largely by taxpayers and/or private citizens to study problems of no immediate or obvious commercial worth. Such scientists assume a great deal of personal and social responsibility to make good on the funds given to support them and not to waste the money or the opportunity.
Nowadays basic, curiosity-driven scientific research is yielding ground in academic environments to engineering solutions to world problems. This shift is healthy, in that too much basic research can lead to research becoming an end in itself rather than a means to improving the world in which we live. However, it is important to appreciate that some scientists are better at conducting basic research and others are better at pursuing applied research, and I am not convinced that you can force one to become the other. It is important that both research niches be encouraged and supported financially, because both need each other to produce a robust and productive research enterprise.
More from the current issue


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Biden Defends Merits of Trans-Pacific Partnership Trade Talks
Vice President Acknowledges Democrats' Opposition to Administration's Push
CAMBRIDGE, Md.—Vice President Joe Biden on Friday acknowledged congressional Democrats' opposition to the Obama administration's trade agenda, but he defended a proposed Pacific pact as an important counterweight to China.
At a retreat of Democratic lawmakers, Mr. Biden said trade negotiations among 12 Pacific countries would bring economic and strategic value, according to attendees. This comes as the White House tries to rebuild the case for trade agreements with Congress and the public and is hoping lawmakers will grant...


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See the list of trendsetters who have had the most influence on the 2017 San Diego A-List.
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Performing high-impact actions such as voting in close races, breaking ties and picking winners will award voters more points.
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Oakland Raiders kicker Sebastian Janikowski will play in Sunday's game against the Denver Broncos, according to league source.
The health of Janikowski, who was injured his hamstring during practice leading up to the 28-0 loss to Kansas City on Oct. 23, was in question after he was limited in practice this week.
Listen to the 2011 NFL season LIVE -- hear all the action online in premium sound quality with NFL Audio Pass. Sign up now!
The Raiders sent home free agent kicker Dave Rayner, who had been on stand bye in case Janikowski was unable to play. Rayner replaced Janikowski against the Chiefs and was cut during the Raiders' bye week and would have been re-signed if necessary.
"I think we're going to be fine, I really do," Raiders coach Hue Jackson told the Contra Costa Times about Janikowski. "But, again, we got to be cautious, just make sure."
Running back Darren McFadden (foot) has been ruled out against the Broncos, while cornerback Chimdi Chekwa (hamstring), safety Michael Huff (ankle) and linebacker Rolando McClain (ankle) are questionable.


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Average Current Mode Control of Bidirectional DCDC Systems
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