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Charity / Cinema Park / digital economy / ecotourism / filedtrips / hiking / Interport / Interros / Interros-Dostoinstvo / Kennedy Center / National Council on Corporate Government / nature tourism / NCCG / Norilsk Nickel / Norilsk Nickel AGM / OPIN / Petrovax Pharm / Potanin / Power Machines / ProfMedia / quadrivalent vaccine / Rosa Khutor / Rosbank / RSPP / RUIE / Russian International Olympic University / Russian Lounge / Russian Union / Russian Union of Industrialists and Entrepreneurs / Soglasie / Sport Connect / sustainable tourism / The National Council on Corporate Governance / Three Volcanoes Park / UNEXIM Bank / vaccine prophylaxis / Vladimir Potanin / Vladimir Potanin Foundation
Forbes Russia released its first ranking of Top-20 charities owned by Russian wealthiest businesspersons.More Topics Charity
The exhibit showcases the cultures of Taimyr's indigenous peoples — the Nganasan, Entsi, Dolgan, and Evenks — in a dialogue with Russian avant-garde and modernism art movements, namely with artworks by Kazimir Malevich, Nikolai Suetin, and Vasily Vatagin, among others.More Topics Norilsk Nickel
Vladimir Potanin spoke at the celebration marking the 20th anniversary of his Foundation. He outlined his vision for the future of the Foundation and explained what parameters he uses to evaluate its work. He believes that charitable work has to take into account feedback: social needs and demands.More Topics Charity / Interros / Vladimir Potanin
On January 3rd Rosa Khutor Ice Palace hosted a fundraiser hockey game with the participation of the national hockey stars. President of Russia Vladimir Putin attended the game between The Hockey Legends and The Night Hockey League teams.More Topics Charity
Norilsk Nickel plans to invest more than $12bn in production development over the next five years in order to boost production volumes, Mr. Potanin told President Vladimir Putin in a meeting on December 10th.More Topics Norilsk Nickel


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Kale isn't quite as healthy as you think it is
We've all heard the buzz about kale being one of those amazing, ultra-healthy superfoods, right? Well, while it might not be quite time to put down the kale smoothies, a new study proves that you can probably lay off them a little. The research, done by the Centers For Disease Control and Prevention, was meant to reveal the top "powerhouse" foods, or, fruits and vegetables that have strong nutritional densities working at preventing illness and disease. A list of 50 powerhouse fruits and veggies was reported, and kale fell lower on the list than we thought it would.
Ranking below watercress, Chinese cabbage, collard greens, spinach, parsley, and even salad bar-staple Romaine lettuce (!), kale ranks at just #15 on the list of powerhouse fruits and vegetables. We're not just surprised -- we're actually kind of shocked, especially considering how much of a good rap kale gets. We're going to start re-thinking our morning smoothie ingredients ASAP. In the meantime, the fifteen most nutritional powerhouse fruits and vegetables are listed below:
1. Watercress
2. Chinese cabbage
3. Chard
4. Beet green
5. Spinach
6. Chicory
7. Leaf lettuce
8. Parsley
9. Romaine lettuce
10. Collard green
11. Turnip green
12. Mustard green
13. Endive
14. Chive
15. Kale
Check out the rest of the list here.

subset: commoncrawl


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European Commission
Brussels, 25 March 2013
Remarks by Vice President Rehn on Cyprus at the Eurogroup Press Conference on 25 March 2013
Thank you for your patience, ladies and gentlemen.
It's been yet another hard day's night. I'm not saying a long and winding road, but it was absolutely essential that an agreement be reached tonight on a financial assistance programme for Cyprus. We now have such an agreement in place, which means that we can now work, starting today, to help the Cypriot people to rebuild their economy.
The agreement was based on a joint proposal of the three institutions, the Commission, the ECB and the IMF. The Commission has been working hard for many months to facilitate a sustainable solution to help Cyprus. In fact I recall that I raised the issue of a financial assistance programme for the first time in November 2011 with the then finance minister of Cyprus, because of the concerns over fiscal sustainability and financial stability. This has been a particularly complex process in the most challenging of circumstances. Already last week, we found ourselves in a situation where there were no optimal solutions available, only hard choices. And that has been even more true in recent days.
It's clear that the depth of the financial crisis in Cyprus means that the near future will be very difficult for the country and for its people. The Commission will do everything possible to alleviate the social consequences of this economic shock and help to protect the most vulnerable people. Cyprus is part of the European family, and Europe will stand by the Cypriot people.
In this context, I can inform you that President Barroso intends to create a Commission Task Force for Cyprus, in agreement with President Anastasiades. The Task Force for Cyprus will provide technical assistance to the Cypriot authorities, with a strong focus on employment, competitiveness and growth. It will be necessary for the Cypriot people to build their economy on a new basis and the Commission is ready to mobilise all the resources at its disposal to help them face that challenge.
I want to say this to our fellow Europeans in Cyprus: Cyprus and the Cypriots have gone through very difficult times before – and you know what I mean – and the Cypriots have overcome these difficult times. There will be tough times ahead now as well, but I'm sure that by working hard together, we shall overcome these difficulties.
Thank you.
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Season finales have their own unique feel, at least to me. 161 games have been played and a lot of passion has been spent. Second guessing the manager's (and General Manager's) decisions became a way of life but now, for one day at least, it becomes irrelevant. If Jerry Manuel wants to use Pedro Feliciano to face Adam Kennedy instead of saving him for Adam Dunn, well, who cares? What's the point in getting worked up about it if this is the last game he'll manage for the Mets?
Today's game reminds me of a similar situation, not that long ago. I was at the final game of the 2004 season (also a Sunday, also October 3rd), when Art Howe was the resident "dead man walking". GM Jim Duquette was planning on letting Howe finish the season, but word got out that he would be fired (sound familiar?). Duquette was forced to announce Howe's dismissal on September 16th, and Howe had to manage the final two and a half weeks of the season knowing that he would be out of work.
It was a lost season: the Mets would finish 71-91. Though there were some positives (the Mets swept the Yankees at Yankee Stadium and had a winning record against their cross-town nemesis rival for the first time), it was mostly negative: there was the infamous Scott Kazmir/Victor Zambrano deal as well as the botched experiment with Mike Piazza at first base. By all rights, game 162 should have been a formality, one last exercise in futility. Maybe it was. Maybe I read too much into what I saw that afternoon, but it felt like more than that.
There was a new era on the horizon: the Mets were clearing the decks, preparing for a new beginning (Omar Minaya would be hired shortly). But there was also a lesson, a hidden message for us all…we'll get to that in a minute.
But first, the game itself. Art Howe wasn't the only Met who would be leaving: John Franco was appearing in his final game. The writing was on the wall: Franco was done with the Mets, and he knew it. Howe did the right thing: Franco entered the game after a nice video tribute in the top of the eighth, replacing Heath Bell. He pitched a third of an inning, gave up a single to Termel Sledge, and got Ryan Church to fly out to Todd Zeile, who was catching that day for the first time since 1990.
Zeile had announced his retirement earlier in the week and Howe chose to let him go out the way he came in. That was the day that I first heard that Zeile was a movie producer, and it was a day that he'd remember forever. Not only did he record the out on the final pitch that John Franco threw for the Mets, but he hit a three-run home run in his final at-bat in the bottom of the sixth. It really was a special moment, the future producer had a real Hollywood moment.
There were other nice moments for the Mets in that game, too. Joe Hietpas had his Moonlight Graham moment and rookie David Wright hit his 14th home run, a two-run shot off John Patterson in the bottom of the third. It was a generally uplifting game: a negative era in Mets history was ending and the future, though uncertain, looked bright. This was highlighted by the unfortunate fate awaiting their rivals that day: the Montreal Expos.
You see, that was the Expos' final game. While the Mets were ending a lost season, Montreal fans were mourning the loss of their team. Those of us in attendance knew we were seeing a major league team's death. The franchise's fate was sealed: they were shortly to become the Washington Nationals (coincidentally, the Mets' opponent in today's finale). Really, we were watching the Expos being taken off of life support.
There was a decent contingent of Expos fans in attendance. They scattered a few "Let's Go Expos!" chants throughout the game, but there was a moment in the top of the ninth where they rallied one last chant. I can't speak for the other fans in attendance that day, but I found it a remarkably poignant moment. Here was a group of fans in a foreign stadium, watching the final moments of their favorite team, saluting them for the final time.
That moment remains fresh for me today. While we think about how poorly our team has played this year, we can look forward 133 days till pitchers and catchers report to Port St. Lucie again. We'll have a new General Manager, a new manager, new players. Our team, no matter how poorly managed, will get another chance to redeem itself. On February 13, 2011, the voluntary reporting date for pitchers and catchers, the Mets will once again take the field. Montreal fans can only wish they could say the same about the Expos.
Bad Mets baseball is better than no Mets baseball, and the 2010 season comes to an end today. Let's enjoy what we have while we can while looking forward to new memories in the coming season. 2011 begins tonight, but today, let's enjoy watching David Wright, Jose Reyes, Josh Thole, Ike Davis, Mike Pelfrey, and all the others write the final chapter of the 2010 Mets. Hopefully, they'll send us off on a positive note.


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There are some big, BIG movies on the horizon for 2015 - The Avengers 2, Star Wars Episode VII - but right now, the one that has most people on pins and needles of excitement is the Batman vs. Superman movie that will serve as the sequel to Man of Steel. We know that the film will supposedly see The Dark Knight and The Man of Steel at odds with one another (before an inevitable team-up), and that the cause of that friction will likely be Batman's distrust of (or anger at) a the fact that an god-like alien is engaging in unchecked (and poorly planned) battles that destroyed Metropolis.
Of course, within that reported narrative framework there arose the question of what version of Batman would we see in Batman vs. Superman; and, if a new rumor is to be believed, then the scenario that many fans (and bloggers) initially guessed at will in fact turn out to be the way the film introduces the world to a new Batman.
According to Batman-on-Film's multiple sources, the Batman in Batman vs. Superman will be an older, already experienced Batman. How much older, do you ask? Well, the rumors state that mid-40s is the age range being sought - but for our own betting money, we'd say between mid-30s and mid-40s is the age range the filmmakers could pull from. The reasoning should be obvious, and is a topic we've discussed on multiple episodes of our Screen Rant Podcast:
The keystone was always Man of Steel; as we said way back: The development of DC's shared universe rested entirely on MoS' reception. If MoS was able to make a favorable impre$$ion (and it has) then star Henry Cavill would headline the franchise and an older, more experienced Batman would be introduced as a guide for the younger, still learning Superman. If MoS had tanked, then it could be written off as a self-contained story (a la Nolan's Dark Knight continuity) and a new, older Superman could be cast as the wise shepherd for younger superheroes like Batman.
Obviously at this juncture, Man of Steel and Henry Cavill are locked in. And, with recent rumors that Zack Snyder is consulting Dark Knight Returns creator Frank Miller for advice on the Batman vs. Superman showdown, it's believable that an older, wiser, Batman - an interpretation Miller explored and one we discussed in our own blueprint for bringing Batman into a Justice League universe - will be what we get.
Unlike so many other websites, our previous list of potential new Batman actors already skews toward actors in the late-30s/early-40s range - actors who would also be affordable and available for what is sure to be a long-running superhero franchise (so, no to those Jude Law, Josh Brolin, or Jon Hamm theories - and let's just put the Christian Bale talk to rest entirely). An older Batman (especially one going up against the likes of Superman) needs to be more sagely and strategy-minded - none of those flimsy gadgets or half-cooked scream loud and attack hard tactics seen in the Nolan films. For our money, actors like Hobbit star Richard Armitage or Fast & Furious 6 star Luke Evans convey that type of personality perfectly (Armitage in particular).
A perfect example of a Batman/Superman team-up done right is undoubtedly the three-part "Wold's Finest" episode of Superman: The Animated Series that aired in 1997. Check out the clip below for example of how an older, more mature Batman keeps step with Superman, and why the worlds of Clark Kent and Bruce Wayne (not just their hero alter-egos) tend to meld so well:
All in all, this reasoning is sound: Batman and Superman having a habit of really helping to inform the other man about who he is, what he stands for, with a nice bit of personal growth inspired by the other man. For Superman of the MoS continuity, this would mean learning to handle problems in ways other than brute force, confronting the death and destruction he caused, and getting a little be less naive about his stature and place in the world. For Bats, coming to trust Superman would pull him a little further out of his dark and cynical world view, would give him something hopeful to truly believe in, and would introduce him to the concept of having friends and relying on others. In short: using the right character setups and development, we could actually get respective Batman and Superman story arcs we've never really seen before (i.e. not origin stories!).
Batman vs. Superman will be released sometime in 2015. Stay tuned for more details as they develop.
Source: BoF & The Independent


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Holbein Acryla Gesso
Size: 300 ml
Color: White Smooth (S)
Holbein Artist Colored Gesso is made with high chroma, lightfast pigments and can be used as a successful ground or as a painting medium on its own. White colored gesso comes in 4 different texture surfaces:
Smooth (S): Extremely smooth surface. Almost like eggshell.
Medium (M): Create a regular matte surface.
Coarse (L): Fine sand texture surface.
Super Coarse (LL): Rough sand texture surface.


text:
Of greater interest to the Doctor is who summoned him. An elderly wizard pushes forward, claiming both responsibility and a link to Earth's ancient past. He, too, has come to this spot in time to defend the Earth. Seeing the TARDIS as a means of escape, the wizard overloads the reactor and calls for the troops to abandon their defense and enter the TARDIS. As they try to make their escape, though, Catavolcus's troops breach the castle. The leader of the defenders--apparently a king--lays down his life so that his men can make it to the TARDIS. They do so. Catavolcus' army is completely destroyed in the subsequent explosion.
Sometime later, the Doctor wakes up in a forest, unsure how he's gotten to where he is. All he remembers is that the wizard and the king called each other "Merlin" and "Arthur".
The Doctor sees an image of Merlin, who tells him they will meet again . . .
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CERAMIC BLOCK MAGNET 4" x 6" x 1/2"
Versatile magnet used for therapeutic use, or for magnetizing your drinking water to North polarity. The Ceramic block magnet is made from 3950 Gauss ceramic material. Encased in heavy duty plastic and clearly marked North on one side and south on the other side of the magnet. Easy to use, simply place a container of water on the magnet for a few hours. Free Shipping.
Use magnetic therapy as a supplement to conventional treatment. This information is provided for educational purposes only. It does not recommend self diagnosis and treatment with magnetic products. Anyone experiencing health problems should consult with a health care professional before starting any new therapy. The author will not be held responsible for anyone using this information to treat themselves or others. Do not use magnets or magnetic therapy if using a pacemaker, implanted medical device or insulin pump as they may interfere with the delicate electronic equipment. Magnetic products are not recommended with transdermal patches or during pregnancy.
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text: Find this wine Find this wine Beronia Taste wine bar Pin It Tweet 6 years ago by Bjessad More posts Beronia reserva 2010, Rioja.£13.49. Available from Waitrose / ocado. Bitter, dry and peppery taste, light scent. Can be kept for up to 10 years. Good with chocolate! 2 star. 4 years ago by Beronia Crianza 2012, Rioja. Available from waitress/ ocado. £10.49. Thin, fresh berries, easy to drink. Maybe good in summer. 2 stars 4 years ago by Beronia Crianza 2009 A true Rioja for a nice price: $13 at Vas Foremost 4 years ago by ThomG Beronia, Tempranillo, Rioja. En mamá mía, San Miguel, con Ivette 4 years ago by Alvaro HP Beronia Rioja 2006 Txikita 5 years ago by Mhoeh


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text:
This oughta raise your blood pressure Min...
"Hominins did not need boats to settle islands"
http://www.newscientist.com/article/dn2 ... lands.html
Seems to be pretty egregious. What would it take to convince the naysayers?
Another similar article:
"Neanderthals were ancient mariners"
http://www.newscientist.com/article/mg2 ... iners.html
They just love to contradict one another, don't they?


text:
More than 150 large dams have been built in West Africa over the past 50 years. Many more are in the planning to meet the region's demands for energy, water and food. But how can these developments rime with environmental sustainability and participatory processes?
A new publication, jointly developed by IUCN, the International Institute for Environment and Development (IIED), and the Institut de Recherches et d'Applications des Méthodes de développement (IRAM), reviewed detailed experiences from six dams in Burkina Faso, Mali and Senegal through the lens of benefit-sharing and compiled these into the report 'Sharing the water, sharing the benefits: Lessons from six large dams in West Africa'.
The publication looks to what extent the affected communities have benefited from the dams and how the multiple consequences from water use have been shared between different actors.
Success in resettling affected people and in rebuilding their livelihoods has been mixed in the region. The lessons learned compiled in the report can guide future decision making on dam developments in the West African region, and beyond.
The publication is available in French and English and was edited by Frédéric Bazin (IRAM), Jamie Skinner (IIED), and Jérôme Koundouno (IUCN).
For more information, please contact Jérôme Koundouno: [email protected]


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Dr. James E. West (May 16, 1876 – May 15, 1948) was a lawyer and an advocate of children's rights, who become the first professional Chief Scout Executive of the Boy Scouts of America, serving from 1911-1943. Upon his retirement from the BSA, West was given the title of Chief Scout. When the new BSA office opened in January 1911 West was at the helm and the movement began to grow at a rapid pace. Sixty local councils were organized in the first month of his tenure. One of his first tasks was the first edition of Boy Scout Handbook. West was instrumental in expanding the third part of the Scout Oath:
- ...To help other people at all times; to keep myself physically strong, mentally awake and morally straight.
He also pushed to add three parts to the Scout Law: brave, clean, and reverent. In November 1911 the title was changed and he became the first Chief Scout Executive.


text:
David Frost
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Ebook Verbände In Der Bundesrepublik Deutschland: Eine Einführung 2004
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Payments: Although we prefer payment for modular ramps at the time of order, we will accept purchase orders from established commercial entities. Large ramp orders may require a deposit at the time the order is placed.
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Ebook Verbände In Der Bundesrepublik Deutschland: Eine Einführung 2004by Emily 4.6
Maximum ramp slope recommended for residential use with assistant.
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text:
Safety and Immune Response to Vicriviroc in Combination Regimens in HIV-Infected ART Experienced Children and Adolescents
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00766597
Recruitment Status : Completed
First Posted : October 6, 2008
Results First Posted : February 1, 2016
Last Update Posted : February 1, 2016
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Condition or disease
|HIV Infections
|Drug: Vicriviroc
|Phase 1 Phase 2
Highly active antiretroviral therapy (HAART) that includes a protease inhibitor (PI) or a non-nucleoside reverse transcriptase inhibitor (NNRTI) has become the standard treatment of HIV-infected adults and children. When effective, HAART decreases the viral population, increases the body's immune responses, and leads to decreased disease progression and increased survival. However, several factors including poor adherence, drug toxicities, and drug resistance complicate HIV management and allow for children and adolescents to develop resistance to multiple drug classes, leaving them with very limited therapeutic options. Fortunately, drugs with new mechanisms of action, such as HIV entry inhibitors, demonstrate activity even in people with resistance to the currently available reverse transcriptase and protease inhibitors.
The purpose of this study is to test the effectiveness and safety of Vicriviroc (VCV), an HIV entry inhibitor. Vicriviroc targets the CCR5 chemokine receptor, which HIV uses to bind and enter CD4+ cells.
This study is a two-stage, age-stratified, non-comparative study to explore the safety, tolerability, pharmacokinetic profile and antiviral activity of the investigational CCR5 inhibitor Vicriviroc in HIV-infected treatment experienced children and adolescents.
In Step I participants will be screened for the co-receptor CCR5 to assess whether they can enter Step II. Only participants with CCR5-tropic virus are eligible for Step II - the main portion of the study to evaluate the study outcome measures. Those participants who continue to Step II will be assigned to one of four age-stratifies cohorts which will receive varying forms, either liquid or tablet, of Vicriviroc:
Cohort I: 12 years to less than 19 years of age, to receive tablet formulation of VCV
Cohort II: 6 years to less than 12 years of age, to receive tablet formulation of VCV
Cohort III: 6 years to less than 12 years of age, to receive liquid formulation of VCV
Cohort IV: 2 years to less than 6 years of age, to receive liquid formulation of VCV
Dose strengths of 20 mg and 30 mg will be used, or in liquid formulation at a concentration of 1mg/mL.
Step II is composed of Stage I and Stage II. Stage I is a dose ranging study designed to explore how the body responds to different doses of vicriviroc, including safety factors associated with dosage. After optimal dosage information and safety measures have been assessed for the different cohorts in Stage I, Stage II will open. Stage II will evaluate the long term safety, tolerability and effectiveness of vicriviroc.
The study, including Steps I and II will last for approximately 48 weeks. Follow-up for all subjects exposed to vicriviroc will last for 5 years after initial exposure. Visits will be every 3 months for subjects on study provided vicriviroc and every 6 months for subjects who discontinue vicriviroc.
The study was terminated shortly after the initiation, when the drug company decided to discontinue development of the study drug. As of study termination, nine participants had enrolled under Cohort I in Step I, but only 4 participants had CCR5 tropism and received the study medication under Step II. All 4 participants had limited post-baseline data.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|9 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Phase I/II Open-Label Study to Evaluate the PK, Safety, Tolerability and Antiviral Activity of Vicriviroc, a Novel CCR5 Antagonist in Combination Regimens in HIV-Infected ART Experienced Children and Adolescents
|Study Start Date :
|August 2009
|Actual Primary Completion Date :
|July 2010
|Actual Study Completion Date :
|August 2010
Experimental: Vicriviroc in tablet form (20/30 mg) or liquid form (1 mg/ml)
HIV-1 Infected Antiretroviral Therapy Experienced Participants with CCR5-tropic Virus
Drug: Vicriviroc
Administered orally in either tablet or liquid form at a dosage of approximately 0.8/mg/kg every 24 hours, with a ritonavir boosted protease inhibitor containing background regimen
- Number of Participants With Suspected Adverse Drug Reaction Leading to Treatment Termination [ Time Frame: From study entry to Week 24 or the early study termination whichever occurred earlier ]The protocol required reporting of signs and symptoms and laboratory abnormalities of >=Grade 2 and all grades of fever. The DAIDS Adverse Event (AE) Grading Table, Version 1.0, December 2004 (Clarification, August 2009) was used for grading of AEs. Expedited adverse event reporting followed Version 2.0 of the DAIDS Expedited Adverse Event Manual.The attribution of relationship of serious adverse events to study drug for the purposes of employing the start, stop and pause rules is to be determined by the Study Team. Gradation of relationship will use the following terminology: Not related, Probably not related, Possibly related, Probably related or Definitely related.
- Number of Participants With Adverse Events of Grade 3 or Higher Severity [ Time Frame: From study entry to Week 24 or the early study termination whichever occurred earlier ]Adverse events were graded using the Division of AIDS (DAIDS) Table for Grading the Severity of Adult and Pediatric Adverse Events (DAIDS AE Grading Table), Version 1.0, December 2004, Clarification August 2009, which is available on the RCC website at (http://rcc.tech-res.com/). All grade 3 and higher signs, symptoms, and laboratory toxicities were included.
- Number of Participants Who Failed to Meet PK Targets [ Time Frame: At Week 24 ]For Stage I subjects who are enrolled in Step II, the average of the pre-dose and 24 hour post dose sample from the intensive PK evaluations of said subjects will be used as the estimate of Cmin. The whole cohort will fail the PK targets if the population target (median vicriviroc Cmin should be =>200 ng/mL) is not met, and that nearly all of subjects' Cmin failed to be > 100 ng/mL.
- Number of Participants Who Failed to Achieve =>1-log Drop From Baseline in HIV-1 Viral Load and HIV-1 Viral Load of =>400 Copies/mL (Virologic Failures) [ Time Frame: At Baseline, Week 24 ]Plasma HIV RNA (RNA) concentrations were determined at entry and at regular intervals using the HIV-1 MONITOR Test, version 1.5 (Roche Molecular Diagnostics) or RealTime HIV-1 (Abbott Molecular). The primary definition of virologic success will require subjects to have achieved and maintained 1-log drops from baseline of HIV-1 RNA or HIV-1 RNA <400 copies/mL.
- Number of Participants With Changes in Co-receptor Tropism From Baseline [ Time Frame: At Baseline, Week 24 ]Among all patients enrolled in Step I, the prevalence of detectable coreceptor phenotype, R5 tropic, R5/X4 mixed and X4 tropic viruses will be evaluated. The extent to which coreceptor phenotype in Step I is associated with Step I CD4 cell count, HIV RNA, and age will be evaluated. The association of Step I coreceptor phenotype and nadir CD4, HIV subtype, number of ART regimens, and years of ART will be evaluated. At the time of virologic failure, the extent of change from Step I and/or baseline R5 tropic virus to R5/X4 mixed or to X4 tropic virus as detected by the TrofileTM assay will be evaluated.
- Change in CD4 Counts [ Time Frame: At Baseline, Week 24 ]Change in CD4 count from baseline to weeks 24 will be presented both in the aggregate and broken down by age cohort.
- Change in CD4 Percent [ Time Frame: At Baseline, Week 24 ]Change in CD4 percent from baseline to weeks 24 will be presented both in the aggregate and broken down by age cohort.
- Change in Polymerase Genome and Envelope Sequence [ Time Frame: At Baseline, Week 24 ]Number of subjects with changes in genotypic and phenotypic drug resistance to the OBT and to vicriviroc (envelope sequence) from baseline to Week 24 and/or virologic failure will be presented both in the aggregate and broken down by age cohort.
- Change in Plasma HIV RNA PCR [ Time Frame: At Baseline, Week 24 ]Changes in HIV RNA (copies/mL) from baseline to Week 24 will be presented both in the aggregate and broken down by age cohort.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|2 Years to 18 Years (Child, Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Confirmed HIV infection
- Treatment experienced subjects: Children or adolescents on an unchanged therapeutic regimen for at least 12 weeks and experiencing virologic failure OR participants on no treatment for 4 weeks or more but with history of virologic failure on a prior therapeutic regimen.
- Likely to have virus that is sensitive to at least one ritonavir boosted protease inhibitor
- HIV viral load greater than or equal to 1,000 copies/ml within 90 days prior to Step I entry
- Able to swallow study medication, in tablets or liquid form specific to age-assigned cohort
- Parent, legal guardian or participant able and willing to provide signed informed consent and to have the participant followed at the clinic site
- Willing to use effective methods of contraception
Inclusion Criteria for Step II (In addition to the inclusion criteria for Step I):
- Participant's plasma HIV tested at Step I must be R5 tropic
- Genotypic sensitivity enabling the participant to take optimized background therapy (OBT) consisting of at least a ritonavir-based protease inhibitor. More information on this criterion can be found in the study protocol.
Exclusion Criteria:
- Presence of any currently active AIDS defining illness or history of malignancy
- History of a seizure disorder that requires current anti-seizure medication for control or at risk for seizures. Those with a history of febrile seizures alone are not excluded.
- Certain abnormal laboratory values. More information on this criterion can be found in the protocol.
- Any vaccinations 14 days prior to Step I, or scheduled to occur within 14 days prior to entry into Step II, and the week 24 and 48 visits in Step II
- Allergy or sensitivity to study drug or its ingredients
- Taking any Step II disallowed medications (see protocol) and unable or unwilling to discontinue them at least one week prior to entering Step II
- Use of NNRTIs other than etravirine 21 days prior to Step II entry
- Pregnancy or breastfeeding. Infants who are receiving breastmilk are allowed to enroll.
Exclusion Criteria for Step II
- All exclusion criteria for Step I
- Participants harboring dual or mixed tropic virus (R5/X4) or X4 virus or non phenotypable virus
- Current or anticipated use of any disallowed medications
- Use of efavirenz, nevirapine, and delavirdine for 21 days prior to Step II entry
- Pregnant within 3 days of Step II entry
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00766597
|United States, California
|UCSD Mother-Child-Adolescent Program CRS
|San Diego, California, United States
|United States, District of Columbia
|Children's National Med. Ctr. Washington DC NICHD CRS
|Washington, District of Columbia, United States, 20010
|Howard Univ. Washington DC NICHD CRS
|Washington, District of Columbia, United States, 20060
|United States, Illinois
|Chicago Children's CRS
|Chicago, Illinois, United States, 60614
|United States, New York
|Jacobi Med. Ctr. Bronx NICHD CRS
|Bronx, New York, United States, 10461
|Bronx-Lebanon Hosp. IMPAACT CRS
|Bronx, New York, United States
|Metropolitan Hosp. NICHD CRS
|New York, New York, United States, 10029
|United States, Tennessee
|St. Jude/UTHSC CRS
|Memphis, Tennessee, United States, 38105
|Puerto Rico
|Univ. of Puerto Rico Ped. HIV/AIDS Research Program CRS
|San Juan, Puerto Rico, 00935
|Study Chair:
|Rolando M Viani, M.D., M.T.P.
|University of California
|Study Chair:
|Stephen A Spector, M.D.
|University of California, San Diego
|Responsible Party:
|National Institute of Allergy and Infectious Diseases (NIAID)
|ClinicalTrials.gov Identifier:
|NCT00766597 History of Changes
|Other Study ID Numbers:
10634 ( Registry Identifier: DAIDS ES )
|First Posted:
|October 6, 2008 Key Record Dates
|Results First Posted:
|February 1, 2016
|Last Update Posted:
|February 1, 2016
|Last Verified:
|December 2015
Treatment Experienced
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Immunologic Deficiency Syndromes
Immune System Diseases


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If you're out and about this Black Friday looking for Windows Phone deals and happen by your local Wal-Mart, have they got a deal for you.
Wal-Mart is offering $100 gift cards for any new and qualified upgrades on their Windows Phones (Android phones are also included). The offer is valid through December 1st and there is a maximum of five gift cards per order.
On top of the gift cards, the prices on the Windows Phones aren't too shabby. The T-Mobile Nokia Lumia 810 is running $149.99, the AT&T Nokia Lumia 920 is $69.99 and the Verizon HTC 8X is $149.99 (all prices listed with a two year contract).
You can find these deals at your local Wal-Mart or over at Walmart.com.
Thanks, blurrz, for the tip!


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Here is your assignment if you choose to play along (cue the Mission Impossible music, please!):
1) It's summertime in the Northern hemisphere, and time for summer vacations for many people.
2) Tell us about a memorable summer vacation when you were a child. What are your memories of summer vacations with your family? Did you travel? How? Did you visit extended family? Who?
3) Share your memories in your own blog post, or in a Facebook or Google+ post.
Here's mine:
1) It's summertime in the Northern hemisphere, and time for summer vacations for many people.
2) Tell us about a memorable summer vacation when you were a child. What are your memories of summer vacations with your family? Did you travel? How? Did you visit extended family? Who?
3) Share your memories in your own blog post, or in a Facebook or Google+ post.
Here's mine:
I remember a number of summertime vacations. Several were to visit family in other states, most notably the family in Louisiana. They were so far away it took a major trip to visit. Others were closer in South Dakota, so we visited them more than just summertimes.
We visited Louisiana several times, but there are only two I recall, once when I was about 8 years old, and the other when I was just about 14. As my birthday is in the summer, those would have been the ages I was advancing to. When I was eight, I remember staying with my Aunt Eva in New Orleans. It's the only time I've ever visited the French Quarter. I have very vague memories of some of the architecture and signage. At that age, I didn't get to really experience the whole New Orleans vibe. No jazz, no Mardi Gras, etc. I do recall one other thing, however, from that trip. We went outside to the lake right across from my aunt's place to look at the moon and stars. Someone there had a telescope, and he let us look through it. I don't remember what we looked at specifically, but I was a space nut when I was a boy, and that fed right into it. That trip was memorable for one other reason: my cousin Sharon Paulette McLin married Michael Andre. I was supposed to be in the wedding, but at the last minute the little girl I was to be walking up with got cold feet or something and dropped out, so they dropped me out, too. Michael and Sharon left for their honeymoon a couple of days later (we went home in the meantime) on their way to Michael's duty station in Germany with the Army. We found out shortly after arriving at home that their plane crashed in New York City (Flight 66) and killed both of them.
The trip to Washington, D.C. was when I was about 11 years old. My uncle and his wife were both deaf, and both worked at Gallaudet College there. We visited the campus one day, and saw some sights while driving, but spent most of the time at their house, playing in the pool and catching fireflies at night. I remember getting stung by a bee on my finger while splashing in the pool. My cousin Maria was 12, my cousin Ricky was about six months older than me, and my cousins Ray and Kathy were both a few years younger. As my brother Mitch was about two and a half years younger than me, we had a couple of small groups we naturally formed. This trip was memorable for another thing – we took the train. My father, brother and I all three went, while mom did something else (I don't remember what, maybe she went back to Louisiana to visit). We rode the Amtrak Empire Builder out of St. Paul, MN all the way to Washington, D.C. where my uncle picked us up. The trip took the majority of two days each way, and was interesting for a while as we explored the length of the train several times, but then got very boring.
One other vacation I remember was to the Black Hills area in South Dakota. I don't remember how old I was, probably 13. We drove out, which took about 10 hours or so of driving time. We stayed in a campground in the hills overlooking Rapid City. It had a pool in which we spent a lot of time, and a net view of the city lights at night. Last time I was out there with my family, we drove past that campground. It's still in operation, or was as of about 2007. We didn't go to a huge number of attractions, but we did go to Mount Rushmore and a couple of other attractions in the area. This trip was one reason I wanted to take my own kids out there when I got my own family. Maybe it will be a tradition they will continue when they also have families of their own.
This and all other articles on this blog are © copyright 2014 by Daniel G. Dillman


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Kindle deals for Christian readers
Here are a whole bunch of new deals for you:
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Oprah, edited
Drew Dyck had some fun with the Oprah quotes on the sleeves at Starbucks.
Gungor, Questions, and the Doubters Among Us
Trevin Wax:
For better or for worse, evangelicalism's lack of authority structure and ecclesial identity open the door for campus ministries, parachurch organizations, and singers, writers, and moviemakers to fulfill the role of quasi-theologians. This is why, when celebrities cross the boundaries of their conservative audience, they get an earful from their constituency, who, rightly or wrongly, feel betrayed by the star's defection.
The left's response to Gungor and Jars of Clay was to celebrate an artist's willingness to boldly "ask questions," to be "authentic," and to reformulate Christianity in ways that take into consideration our contemporary setting. The conservative response was to decry these artists as defectors from the faith and to write them and their questions off.
My Facebook feed was filled with both responses – those who praised the courage and creativity of Gungor, and those who condemned their unorthodox views. Both attitudes left me unsatisfied. Here's why.
On Nude Celebrities, Virtual Voyeurs, and Willing Victims
Tim Challies:
But there is still another aspect of their victimization I want us to see: The very fact that these women took these photographs in the first place is proof that they are victims of the world, the flesh, and the devil. I assume they were all willing participants in these photo shoots, but they were victims even in their willingness—victims of those forces that makes them believe they are nothing more than their beauty, their sexiness, or their sexual desirability. They are victims of the lust that drove them to inappropriate sexual relationships outside of marriage. When we understand sin, we understand that a person can be a willing participant and victim at the same time and in the same act.
Karen Swallow Prior's recommendation for a novel every Christian should consider reading
Probably the most unique selection in this series so far. (Also, by far one of my favorite blog series from Justin Taylor.)
When Pastors Experience Depression
Thom Rainer:
Depression was once a topic reserved for "other people." It certainly was not something those in vocational ministry experienced. Perhaps it would be more accurate to say that ministers rarely admitted that they were depressed. After all, weren't these servants of God supposed to have their acts together? How could pastors and other ministers who have the call of God on their lives experience the dark valley of depression?
Ministers often feel shame and failure when they go through bouts of depression. And their reticence to tell anyone about their plights has exacerbated the problem.
But today more and more ministers are willing to talk about this issue. Articles in Christian Post, the New York Times, and Paul Tripp's Gospel Coalition blog address the problem candidly and proactively.
The Cloak of Righteousness
Lore Ferguson:
This morning I woke thinking of all the ways I have failed, all those I have failed, and all the failures yet to come. How could a holy God condescend to me? How could he fit his goodness as a cloak on me? Surely I have toed the line of arrogance and fear and anxiety and lust and envy and all kinds of sin, enough that I have gone out the bounds of his demands.
But if Salvation is to "make wide" or to "make sufficient," then the salvific act was one that spread wide around the boundaries of every one of my days and sins and weakness and proclivities and covers them all.


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I've made no secret of the fact that Allen Steele is one of my favorite science fiction writers and has been for some time (he was the first author I ever sent fan mail to! True fact!), and his excellent new novel Hex shows one of the reasons why: The dude thinks big. Like, really big. We're talking Dyson Sphere big. But Allen's not content to just take received wisdom about what science fiction has already said about things like the Dyson Sphere — no, he's going to put his own spin on it. How so? Allen reveals all, in its Brobdingnagian splendor.
So you want to talk about big ideas, do you? Try this one for size…
Imagine a world one AU in radius – that's 93 million miles – and 186 million miles in diameter, with a circumference of 584,336,233.568 miles. Since this world is hollow, with a G-class sun at its center, it has an estimated volume of 1.086×1017 miles (I don't think there's a word for a number that big). Its surface isn't solid, though, but instead is comprised of approximately six trillion open-center hexagons, each having a perimeter of 6,000 miles. Every hexagon has six cylindrical habitats 1,000 miles long and 100 miles wide. Most, if not all, of these "biopods" are inhabited by one alien race or another, and no one knows for sure how many live here … except perhaps the danui, the ones who built this place, and they're not telling.
That's Hex.
I've been fascinated by Dyson spheres ever since I read Bob Shaw's Orbitsville, the first novel to deal with Freeman Dyson's concept (yes, I know all about Larry Niven's Ringworld … but that isn't a sphere, is it?). Since then, I've read or seen other treatments of the same idea – notably the shellworlds of Iain Banks's Culture novels, and "Relics", one of the better episodes of Star Trek: The Next Generation – and have generally enjoyed them all.
Nonetheless, a number of things have always bugged me. Looked at from a practical point of view, Dyson spheres don't seem to make a lot of sense. Build a solid sphere around a star, and you'll inevitably run into a couple of big problems: namely, a runaway greenhouse effect will eventually make the place uninhabitable, which will probably occur shortly before trapped heat causes the shell to overheat, expand, and fracture just like a sidewalk in summertime.
And even if you ignore all that, there's also the question of purpose: why build something this enormous if it can have only one kind or environment? Orbitsville, for example, has a nitrogen-oxygen atmosphere, an everlasting summer, and endless plains of grass. Not only is that … well, rather boring, if you ask me; I like winter, and I love cross-country skiing … but it's also a waste of potential; thousands of different, non-human races could comfortably reside in something like this, if only there were more environmental variation.
I'd been muddling this stuff around the time I finished Coyote Destiny, the fifth and last book of the Coyote series. This was the conclusion of an epic I'd been writing during the last ten years; during the same time, I'd also done two novels set in the same universe, Spindrift and Galaxy Blues, which formed a parallel storyline to the events taking place on Coyote. Now that the Coyote series was complete, I wanted to provide a capstone for the spinoff novels as well. And since this would probably be my last hurrah, I wanted to go out with something big.
Which brought me back to Dyson spheres and all the questions I had about them. Freeman Dyson is a very smart man; I could not believe that one of the leading physicists of our time would devise something which had such obvious flaws. So I visited the University of Massachusetts science library, tracked down the issues of Science from 1960 in which Dr. Dyson published a couple of letters explaining his idea, and got a surprise: the Dyson spheres of science fiction bear little resemblance to his original concept.
Dr. Dyson had suggested that these spheres would be individual habitats orbiting a star, rather than a solid shell with a sun at its center. In fact, he owed his inspiration to J.D. Bernal's The World, The Flesh, and the Devil, published in 1929, which discussed the possibility of something rather similar. All right, this made sense … except that, with zillions of these habitats spinning around a star, you'd have one mother of a traffic-control problem. And not only that, but wouldn't it make sense to connect them somehow, so that inhabitants could easily travel from habitat to another?
I was thinking about this when I stumbled upon a web site article about the properties of fullerenes, sometimes also known as buckyballs. The article featured a diagram of a carbon-based fullerene … but to my mind's eye, it was a Dyson sphere, only with a framework of six-sided habitats around a central point.
So my Dyson sphere would be something like that: a vast assembly of hexagons, each one sharing sides its neighbors, constructed in orbit around a star. An afternoon spent doing the math for the dimensions of such an object producing bowel-loosening results. Don't ask what the mass of this thing would be; a fan tried to figure it out when I described Hex to him, and threw down his pen in frustration.
Once I drew pencil sketches of Hex, my friend Rob Caswell came up with the frontispiece illustrations that appear in the book. Rob also read the book as I was writing it and made several suggestions. And I had great fun coming up with the different aliens that appear during the novel; some, like the hjadd, had previously shown up in Spindrift, Galaxy Blues, and the Coyote novels, but others like the danui and the soranta haven't been seen before.
Figuring out why someone would go to the trouble of building something like this provided me with much of the plot and story. I won't go into that here, except to say that Hex isn't a Big Dumb Object; it's a Big Smart Object, its creators haven't disappeared, and their motives are eventually explained. You'll have to read the book to learn more.
Hex is about the discovery and exploration of Hex. But despite what I said at the beginning of this essay about this novel being a series finale, I'm not entirely certain that I'm done with this place. I've got some questions of my own that I'd like to have answered.
Hex: Amazon|Barnes & Noble|Indiebound|Powell's
Read an excerpt. Listen to an audio interview.


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Worldwide Unemployment Crisis: There Are 93 Million Unemployed Workers In G20 Nations
By Michael Snyder
July 19th, 2013
Did you know that the total number of unemployed workers in G20 counties is now up to 93 million and that it is increasing with each passing day? You see, the truth is that the United States is not the only one dealing with a systemic unemployment crisis. This is literally happening all over the planet. So what is causing this crisis? Is there any hope that it will be turned around? Well, unfortunately there are several long-term trends that have been developing for decades that have played a major role in bringing us to this point. First of all, the giant corporations that now totally dominate the global economy have figured out that they can make a lot more money by replacing expensive workers that live in major industrialized nations with workers that live in nations where it is legal to pay slave labor wages. So it isn't really a huge mystery why there is such a huge problem with unemployment in the western world. If you were running a giant corporation, why would you want to hire workers that will cost you 10 to 20 times as much as other workers? A worker is a worker, and over the past decade we have seen a massive movement of jobs to countries where labor is cheaper. In addition, large corporations are also trying to completely eliminate as many jobs as they can by using technology. If a corporation can get a computer or a machine or a robot to do a task more cheaply than a human worker can do it, then why would that corporation want to continue to rely on human labor? And of course we have seen an overall weakening of the economies of the western world in recent years as well. This has been particularly true in the United States. As these long-term trends intensify, the worldwide unemployment crisis is going to get even worse.
The Rest…HERE


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Below is your personalised "Number one song on my birthday" tracklist.
Each of these tracks was a US number one hit on your birthday, October 28th since 1940. This list is currently showing #1 songs from 1940 onwards.
Click 'More #1 Songs' to see the next batch of songs that were #1 on your birthday. At the end of the list you can download shareable list of tracks or download a Spotify playlist. Alternatively, click on any track to view a video and access the Spotify tracklist.


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- on desidia's page
You look amazing with your pink highlights Mnislahi :). Such beautiful scenery as well, please tell me you were allowed to stay there over night <3 :) lol
SG Set
Yay!! New set after years on MR!! Show me some love!! Mwah!!
VIEW 25 of 28 COMMENTS
Everytime I think I'm done, I get an email saying I can come back. Gots to say hey to all thems people from the way back in the when. P.S. Serious Question: Did you ever make it to the D.C. Zoo?
Tree Octopus
SG Set
by sobelle
VIEW 19 of 19 COMMENTS
#SGFLShootFest2012 on Instagram for awesomeness
VIEW 10 of 10 COMMENTS
wow i didnt realize how long youve been on the site for,
it was great to meet you
youre gorgeous
it was great to meet you
youre gorgeous
I think I'm overdue for a new set.
VIEW 25 of 31 COMMENTS
I forget if i asked you where in Florida you live.. but if you're in Miami come get your hair done at my salon! You'll love it! <3
I know I'm late at this but I'm really digging the instagram! Follow me there! : @mnislahi.
Send me yours!
Send me yours!
VIEW 12 of 12 COMMENTS
I miss being super active on the site. I may just have to fix that!
VIEW 25 of 30 COMMENTS


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Sorry! This giveaway is now closed! We would like to congratulate Commenters #284 & #156 on winning these gift cards. Happy Holidays, everyone!
When I was asked if I would like to go on a shopping spree with a $200 Sears Gift Card for the holidays, I could not agree fast enough. Who wouldn't want the opportunity to shop for for free? Lucky for me, this card can not only be used at Sears, but I could take it over to Kmart to get even more holiday shopping done. Our stores just happen to be on the same road so I hit the main drag to get the rest of my holiday shopping done.
At Kmart I was able to purchase three beautiful scarves for only $6.49 each (for my fashionista sister-in-law), beautiful dishtowels from the Country Living line for hostess gifts, a Rock 'Em Sock 'Em game for my nephew, and two Thomas movies with wooden trains for my other nephew (for only $5 each!)
On my stop to Sears, I swung by the clearance section and found two beautiful digital frames to send to the grandparents for only $69.99. They held 3,000 pictures and could store even more with an additional memory card. I ran right home and loaded them both with oodles of pictures of their grandchildren as a special holiday gift that will be remembered for years to come. My out-of- pocket expenses after all of this shopping… a mere $5.50. I am so proud of the gifts that I chose and was blown away with the variety of items I was able to choose from with this gift card.
There were so many budget-friendly choices and the versatility of being able to shop with at so many different stores is what makes this gift card so unique. I was able to pick out gifts in every price range and saw so many more gifts that I could get next year. Beautiful chunky sweaters on clearance, perfumes and cologne, jewelry, cashmere throws, fashion accessories, and tons of toys & games all could be purchased with just one card. Unbelievable!
The Sears & Kmart gift card is redeemable at Sears,on Sears.com , Kmart, on Kmart.com, Lands End, and LandsEnd.com! All of these combined offer such a wide variety of brands for you to choose from, which most single-retailer gift cards don't provide.
I wouldn't just tell you about my amazing shopping experience though, I just had to share this great shopping experience with you. Today we are giving away TWO $50 Sears/Kmart gift cards that you can use towards your holiday shopping. To enter, please share with us one way you would maximize this gift card to tackle the remainder of your holiday shopping. Entries will be taken through Tuesday (12/22) at 8PM EST. Our winner will be drawn at random. Good luck, everyone!
This product was received as a review sample. The thoughts and opinions expressed will always be honest and heartfelt and no reflection on receiving a sample copy. We promise to always do our best to also give away each of these products to our readers because it is always better to give than to receive! Want to know more about how things are handled here at MomAdvice? Be sure to read our Disclaimer which clearly states how things work and know that we will always offer only the best reviews to our readers.


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February Book Club: Bridge of Birds Wrap-Up & Your Feedback!/
It's time to find out what everyone thought of Number Ten Ox, and check in on Goodreads for suggestions on good old-fashioned popcorn sci-fi and amateur cartography for our favorite fantasy realms. Enjoy!
More on our February pick, Bridge of Birds:
On GoodReads: http://www.goodreads.com/book/show/15...
Hughart Fan Site: http://www.barryhughart.org/books.htm
Discussion Links:
"Magical Realism in BoB" by Timm:http://www.youtube.com/watch?v=cDVIjM...


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|Harbor View
|Color Photograph
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Bob Avakian and his wife Gail visited Martha's Vineyard for the summer in 1973 and it has been home ever since. As his photographic vision has evolved he has been drawn to the natural landscape and an exploration of night photography. Recently Bob's night photography was awarded First Place in the Neutral Density Photography Awards 2014. He was selected as a Photolucida Critical Mass 2013 Top 50 photographer. In the International Photo Awards Annual competition Bob won 2nd place in the Night Photography category. In Photo Nights Boston's "Photorama" his photography won 1st place. His work was also chosen to exhibit in the Danforth Museum's "Photography Bienniel" and at the Cape Cod Art Association's "All New England", where he was awarded Best of Show. Bob has exhibited work from his series "Between Night and Day" at the Davis Orton Gallery in Hudson NY in a two person show with photographer Stephen DiRado. He was awarded a solo show of the series at the South Shore Art Center in Cohasset MA and in March 2013 he was the Featured Artist on the Photographic Resource Center, Boston's website PRCNEO. His photos have been featured in Aline Smithson's, "Lenscratch"; in Wilson Cummer's New Landscape Photography blog and on the popular photo site Peta Pixel. His work is in the collection of The Boston Athenaeum and the Martha's Vineyard Hospital's permanent art collection. He is a juried member of the Cape Cod Art Association and the South Shore Art Center in Cohasset, Ma. RESUME SOLO AND TWO PERSON SHOWS 2016 The Granary Gallery, Martha's Vineyard, MA 2015 The Granary Gallery, Martha's Vineyard, MA 2014 June, Cape Cod Art Assoc. Selected Solo Exhibit 2014 August, The Granary Gallery, Martha's Vineyard, MA 2013 Davis Orton Gallery, Hudson, NY Night Photography: Stephen DiRado & Bob Avakian 2013 Photographic Resource Center, Boston, Northeast Exposure Online, March Featured Artist 2013 South Shore Art Center, Gallery Prize Award-Solo Show, June-July, William Baczek-juror AWARDS 2016 Cape Cod Art Association: The National, Best American Landscape 2015 Focus Photo LA: Top 20 Finalist 2015 Photoville: The Fence, Boston 2015 Soho Photo: "Portfolio Contest" Finalist 2015 PX3, Fine Art Landscapes, Bronze 2014 Neutral Density Photography Awards 2014 1st Place, Night Photography 2014 Santa Fe Workshops "Water" Honorable Mention 2014 Cape Cod Art Assoc. "All Cape Cod" First Place Photography 2014 Still Point Art Gallery, "Landscapes by Day- Landscapes by Night" Best in Show-Portfolio. 2013 Photolucida Critical Mass Top 50 Photo Nights Boston, Photorama 2013 First Place Overall 2013 Cape Cod Art Association's "All New England" Best of Show 2013 International Photography Awards 2nd Place, Night Photography 2013 Cape Cod Art Association "All Cape Cod" 2nd place photography 2012 Photolucida Critical Mass 2012 Finalist 2012 International Photography Awards Honorable Mention, Night Photography & Honorable Mention, Landscapes 2012 Cape Cod Art Association's "All New England" 2nd Place Award, Photography 2012 All Island Art Show, Martha's Vineyard, Ma. Best of Show 2012 Cape Cod Art Association's "The Big Picture" 2nd Place Award JURIED GROUP SHOWS 2016 Center for Fine Art Photography: Portfolio Showcase #9 2016 Cape Cod Art Association: All New England 2016 Cape Cod Art Association: All Cape Cod 2015 Danforth Musuem of Art, Community of Artists, Honorable Mention 2015 Focus Photo LA: Photo Basel 2014 PhotoPlace Gallery: "The Built Environment" Brian Vanden Brink 2014 Diffusion: "The Matter of Light" Blue Mitchell 2014 Griffin Museum of Photography "20th Juried Exhibition" Aline Smithson 2014 Danforth Museum, "Community of Artists" 2014 New York Center for Photographic Art "Same but Different" 2014 Project Basho "Onward Compe 14" 2013 Danforth Museum, New England Photography Biennial 2013" Francine Weiss 2013 Griffin Museum of Photography "19th Juried Exhibition" Kathy Ryan 2013 Kiernan Gallery "Portfolio Showcase 2013" Lexington, VA. Vicki Goldberg 2013 Soho Photo Gallery, NY, "National Competition", Ms. Laura Paterson, juror 2013 SchoolHouse Gallery, Provincetown, MA. "Annual Juried Show" Arlette Kayafas, juror 2013 South Shore Art Center, Photography Now, Karin Rosenthal, juror 2013 Vermont PhotoPlace Gallery, The Magic of Light, Aline Smithson, juror 2013 Cape Cod Art Association, "All Cape Cod" 2012 Cape Cod Art Association, "All New England" 2012 Griffin Museum Of Photography, "18th Juried Show" Paul Kopeikin, juror 2012 Cape Cod Art Association "The Big Picture" Paula Tognarelli, juror 2012 Greg Moon Art, Taos, NM, "After Dark" Greg Moon, juror 2012 Gallery Seven, Maynard, MA "Into the Night" Lance Kemig, juror GROUP EXHIBITIONS 2014 The 28 & Bank Gallery "Night Photography" 2014 Photolucida Critical Mass 13 "How one thing Leads to Another" Gordon Potts Gallery and Houston Center for Photography 2013 South Shore Art Center, Invited Member Show 2013 Griffin Museum of Photography, Atelier 17 show 2012 Griffin Museum of Photography, Atelier 15 & 16 shows COLLECTIONS The Boston Athenaeum The Martha's Vineyard Hospital Permanent Art Collection. PUBLICATIONS 2016 Solsitce Literary Magazine 2016 Dodho Magazine: Issue #2 2015 Dodho Magazine "Night Photography by Bob Avakian" 2014 Gallery Kayafas: 'Out of the Frame" 2014 Peta Pixel "New England at Night" An Interview with Bob Avakian 2013 Vineyard Style Magazine, Spring Issue, Photography feature 2013 Lenscratch online Blog, Featured Photographer, January 15th 2013 New Landscape Photography, Wilson Cummer, featured on June 24 2013 Photo Eye: Art Photo Index AFFILIATIONS Juried Member: Cape Cod Art Association Juried Member: South Shore Art Center


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Washington Sketch
Obama's new Gitmo policy is a lot like Bush's old policy
Tuesday, March 8, 2011
It was another important moment in the education of Barack Obama.
He began his presidency with a pledge to close the military prison at Guantanamo Bay within a year. Within months, he realized that was impossible. And now he has essentially formalized George W. Bush's detention policy.
With Monday's announcement that the Obama administration will resume military tribunals at Gitmo, conservatives rushed out triumphant I-told-you-sos. Liberal supporters were again feeling betrayed. Administration officials had some 'splainin' to do.
And so they assembled some top-notch lawyers from across the executive branch and held a conference call Monday afternoon with reporters. The ground rules required that the officials not be identified, which is appropriate given their Orwellian assignment. They were to argue that Obama's new detention policy is perfectly consistent with his old detention policy.
Not only had he revoked his pledge to close Gitmo within a year, but he also had contradicted his claim that the policy "can't be based simply on what I or the executive branch decide alone." His executive order did exactly what he said must not be done, in a style pioneered by Obama's immediate predecessor in the Oval Office.
"This detention without trial - what's different from the Bush administration?" a French reporter from Le Monde asked during the call.
Good question. The answer, from the Anonymous Lawyers, was technical. "We have a much more thorough process here of representation. . . . There's an opportunity for an oral presentation to the board."
CBS's Jan Crawford was not impressed by this answer. "What specifically is different in this than what we were living under that was so bad in the Bush administration?" she asked.
The Anonymous Lawyers replied that cases would be reviewed every six months instead of every year. They also spoke about their "intent to comply with Article 75 of Additional Protocol One."
This still wasn't working for Yochi Dreazen of the National Journal. "It seems like what is happening now with this executive order is effectively ratifying the status quo," he said. "Is that a fair read?"
The Anonymous Lawyers did not think that was a fair read. Over and over again, they repeated their theme: "The basic message is the National Archives speech remains the framework under which Guantanamo closure is being done."
Oh? Let's review.


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Broward High Schools
Plantation American Heritage girls' soccer wins Class 3A state final
A program that has become quite accustomed to success and state championships added another one to its trophy case on Friday night.
The Plantation American Heritage girls' soccer team had a bigger challenge than usual in front of it. Taking on a revenge-minded Merritt Island team that had lost to them in each of the past two regional finals and had a large and noisy crowd behind it, the Patriots never blinked as they controlled most of the game and cruised to a 3-0 victory in the Class 3A state championship game at Eastern Florida State College.
And with that, Heritage, ranked No. 3 in the nation in the NCSAA poll, finished its season unbeaten at 29-0-1. And on the way, outscored its opponents from the district semifinals on by a combined 40-0, notched its eighth overall state championship, second in a row and fourth in the past six years. They trail only St. Thomas Aquinas for most state championships, and the Raiders can win their 13th by beating Vero Beach on Saturday evening.
"This never gets old. A great feeling and I'm really happy for the girls because they really worked hard," Heritage coach Cindy Marcial said. "Everyone thinks you just step onto the field and put on an American Heritage shirt and you win, but it's not that easy. It's a lot of hard work. Once you start the playoffs, it's eight more games, plus a lot of them play club and you have to try and constantly work to keep them sharp and motivated. The bar is set very high around here, and winning back-to-back is hard to do. I don't care how much talent is on the field."
After controlling virtually all of the first half with the ball in the Merritt Island end, the Patriots broke through with 26:15 left in the first half when Martha Thomas rifled a perfect pass to the left side for Melanie Monteagudo, who patiently dribbled her way closer to the net.
When Merritt Island keeper Jasmine McGowan committed to her right to meet Monteagudo, Broward county's scoring leader this season with a county-record 61 goals made it No. 62 by left-footing a low ball just inside the right post.
"Mel's goal was big," Marcial said. "We always like to get one in quick if we can and get the lead."
With just under 13 minutes left until halftime, it looked like the Patriots would make it 2-0 when Dejah Cason picked a Merritt Island defender clean of the ball on the right side, fired a perfect centering pass to Michaela Kopecki who was charging to the net and fired.
But McGowan dove to her right and made a spectacular horizontal save keeping it a one goal game.
In the game's 55th minute, Heritage was awarded a corner kick and, with the wind blowing toward the net, Michaela Kopecki hooked a perfect shot. McGowan went up high but the ball glanced off her fingertips and into the net with 24:15 left.
"I knew once we were up by two, we were playing lock-down defense and had it nailed," Kopecki said.
Monteagudo capped things off with just 90 seconds left when she scored her 63rd goal, a perfect hook shot off her left foot from 20 yards out into the top left corner of the net.
"Getting that first goal early was big," Monteagudo said. "We knew coming in how loud their fans were going to be and were prepared for it and knew we'd need to get an early goal to quiet them down.
"This feeling never gets old. We've been in three of these in a row and the one you remember the most is the one you get beat in and that happened two years ago and we didn't want it to happen again tonight."


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"The quality of your commitments will determine the course of your life." – Ralph Marston
Recently, I spoke to a room full of high school students on the topic of "Don't Waste Your Life." Among the advice that I gave them, I offered this nugget of truth: "Don't just drift through life. Live intentionally and on purpose." I believe that is one of the most important lessons that a person can learn—and the sooner we get it, the better.
Living a simple life certainly requires intentionality. In a world that is hectic, busy, and hurried, simplicity is not. In a culture that encourages selfishness and excess, minimalism does not. And in a society that is rushing to gain more, satisfaction with less is counter-cultural.
To live an intentional life, we must begin by laying a proper foundation and then add practical steps on top of it.
First, Lay the Foundation.
- Realize that your life is made up of choices. Every morning is a new day full of decisions and opportunity. You get to pick your attitude and your decisions. You don't have to let the circumstances of your past negatively determine the pattern of your life in the future. You have a choice in the matter. You do not need to be stuck in the same pattern of living that you have been for years… realize that every morning is a new opportunity.
- Evaluate the culture that you're swimming in. Life is not lived in a vacuum. It is lived surrounded by a culture that is moving somewhere. This culture around us forms a swift downstream current. Living an intentional life will require you to take a step back and evaluate the flow of the stream to determine where it is headed, how it is affecting you, and if it is taking you in a direction you desire.
- Examine yourself. Know who you are. Get a strong handle on your passions, talents, abilities, and weaknesses. Give precious time and energy to this endeavor. It is one of the most valuable things you can do.
Second, Add Practical Steps.
- Decide to live your life. Stop comparing yourself to others. You were not born to live their life. There is no sense wasting yours being jealous of theirs. Instead, you were born to live your life – determine today to be good at it. After all, you only get one shot.
- Define a purpose. Identify what you want your life to communicate and contribute. Find a passion to live for that is bigger than yourself. Write it down. It will bring new meaning to your life. It will wake you from the slow death of only living for yourself.
- Set goals. Goals move us and goals shape us. Set goals that are directly in line with your defined purpose. By their very nature, they will introduce intentionality into your life.
- Stay focused. We live in a world of constant connectivity and distraction that is begging for our attention nearly every moment of the day. Learn to turn off the distraction and live your life instead. Turn off the tv and don't read gossip magazines. Remove nonessential physical belongings that are robbing you of time and energy that could be better spent living intentionally.
- Learn from others. Successful people are curious people. They possess the humility to learn from others. Identify people accomplishing your purpose and goals. Then, study them and learn from them.
The worst thing you could ever waste is your life. Instead, commit yourself to live intentionally and on purpose.


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Obama can't get ahead of NSA story
President Barack Obama has the surveillance leak response down pat: Wait a couple of days after a rough story, then tell reporters most of what they already know.
What the White House hasn't done is get ahead of the story.
Story Continued Below
The administration's pattern was in full effect Wednesday, when it got lapped by the National Security Agency news cycle. While three senior officials were explaining newly declassified documents that were largely reported by the Washington Post last week, reporters wanted to know details about a fresh Wall Street Journal NSA scoop from the morning.
Basic crisis management dictates that you push out as much information about the story as possible as soon as possible, but the White House's public relations effort has been complicated by its inability to predict the next wrinkle to the story. It doesn't know what revelations are coming next — or when.
( PHOTOS: Pols, pundits weigh in on NSA report)
That makes it difficult for the president to maintain credibility when telling the American people they have nothing to fear about the programs.
"This is a secret system and it has to be secret, but it depends on public trust and credibility," Sen. Richard Blumenthal (D-Conn.) told POLITICO. "The president is doing his best to try to sustain it, but the nature of the disclosures and drip-by-drip revelations at a certain point are greater than the sum of their parts."
It can take several weeks to declassify FISA-related documents because of the inter-agency cooperation that often is required. Administration officials have been left to complain that what's leaked hasn't told the whole story without being able to tell the whole story themselves, and waiting days after the fact to add context is far too long for an effective response.
( Also on POLITICO: Lawmakers, privacy groups rattled by latest NSA reveal)
"The administration is full steam ahead at the president's directive that we declassify and make public as much information as possible," National Security Council spokeswoman Caitlin Hayden said. "But declassifying things doesn't happen instantaneously. These things are classified for a reason, and it is incumbent upon us, even as we move quickly, to take into account all the national security interests that might be affected, whether they be legal or operational or otherwise."
The delayed response often reveals itself in comical ways.
Take Wednesday: Senior officials from the National Security Agency and the Office of the Director of National Intelligence held a 35-minute call, on background, with reporters to discuss documents showing NSA for three years collected emails that were "wholly domestic" and entirely unrelated to terrorism. But when predictable questions came about the Journal report that the NSA's surveillance network can cover up to 75 percent of U.S. Internet traffic, the officials clammed up.
"I'm really here to talk about the documents being released today," one of the officials said.
( Also on POLITICO: NSA collected non-terrorism-related emails)
Another chimed in: "We're here to talk about these documents and that's not covered in these documents so we're just not in a position to talk about it."
"We're really here to talk about the documents that are being released today, not the Wall Street Journal article," another said.
Hours later, shortly before 11 p.m. Wednesday, the NSA and ODNI released a joint statement to reporters responding to "press reports based on an article published in today's Wall Street Journal," but made no specific quibble with the Journal story itself. The statement ticked through what it described as misleading characterizations emanating from the Journal's report.
But by then dozens, if not hundreds, of stories had been written based on the Journal's reporting.
"At some level they become a piñata out there where they're having to answer questions and they have no control over the flow of information," said Clinton White House press shop veteran Chris Lehane.


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The team at Gentelman Squid Studio have released their latest indie video game, Rise of the Ravager, and chose royalty free production music from Productiontrax.com to power their intense and epic soundtrack.
In this latest video game for Windows, Linux, and XBox platforms, a god desires to be reborn, an event that would signal the End of Times. In Rise of the Ravager, gamers seek favor from the Old Ones to prevent the god's avatar from destroying all. Play alone, or invite up to three friends to blast hordes of enemies utilizing a unique combat system based on color.
"The game features songs purchased from productiontrax.com along with some original compositions. Songs that were purchased were strictly from Productiontrax.com," explains Studio Director Fabian Florez. "Trailer music was also purchased from Productiontrax."
Both the game's and trailer's soundtracks are full of epic and dramatic royalty free music tracks, featuring huge sounding drums, choirs, and orchestral effects fit for the big screen. Flores and his team relied heavily on the low-resolution comps from Productiontrax in production. "The site is great and [we] really appreciate the comps in order to see how music fits in our game. I'm so thankful for the artists to supply music like this for your website."
You can check out the game at http://www.riseoftheravager.com.


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Micro-needles could painlessly tattoo DNA vaccines into the skin
Patches covered in microscopic needles could tattoo vaccines into the skin to boost a patient's defense against disease, researchers say.
Vaccines help bodies develop immunity to diseases by exposing immune systems to potential invaders. Scientists are now developing DNA vaccines that deliver genes from contagions into patients; the cells of vaccinated people then churn out molecules from those potential intruders that function like wanted signs, helping immune systems recognize dangerous threats.
In principle, DNA vaccines possess a number of benefits over regular vaccines. For example, instead of wasting time and resources generating and purifying proteins from germs for use in vaccines, manufacturers can simply get the human body to do the manufacturing work. However, so far DNA vaccines have not proven very effective in humans, perhaps because there has been no good way to give patients enough of the vaccine in a shot.
[Porcupines Inspire Less-Painful Needles]
Scientists have tried a number of strategies to make DNA vaccines more effective, for instance, using electrical zaps that make cells more permeable to DNA. However, this approach can be painful.
Instead, researchers at MIT sought to deliver DNA vaccines using arrays of microscopic plastic needles only 250 microns wide and 650 microns high. By comparison, the average human hair is about 100 microns wide.
Researchers coat these microneedles with biodegradable films containing the vaccine as well as a variety of other molecules, such as compounds that stimulate immune systems and help cells absorb DNA. Applying patches loaded with these needles onto the skin instantly embeds the coatings into the body, much like the application of a tattoo.
These microneedles can be designed to disrupt only the most superficial layers of the skin to avoid nerve endings and blood vessels, making them painless and safer than hypodermic needles.
"Comparing it to feeling like a cat's tongue is quite accurate," researcher Peter DeMuth, a biological engineer and materials scientist at MIT, told TechNewsDaily.
The coatings remain implanted even after the microneedle patches are pulled off. Coatings also dissolve in a controlled manner, releasing the vaccine and companion molecules over a sustained, and adjustable, period of time, which can be from days to weeks.
"We have very direct control over how the vaccine is delivered, and the prolonged exposure to the vaccine that is possible with this system can really enhance immunity," DeMuth said.
Scientists tested the patches on rhesus monkeys, measuring how much of a protein encoded by a DNA vaccine the animals would produce. The monkeys generated 140 times as much of the protein in response to microneedles as they did when injected using normal, hypodermic needles.
"We brought together a number of interesting, different technologies, and the results are striking," DeMuth said.
Moreover, these patches can be stored at room temperature for weeks at end without loss of potency. This makes them more amenable to global distribution than solutions of vaccines, which demand refrigeration to stay active and are more expensive and complex to distribute.
The scientists detailed their findings online Jan. 27 in the journal Nature Materials.
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