text:
Eric Young pushes Mets past Braves with three hits, three steals
Eric Young Jr. is proving he's an important part of the Mets' winning formula.
That's especially important with New York's outfield about to become more crowded.
Young got three hits, stole three bases and scored four times as the Mets overcame Justin Upton's two home runs to beat the Atlanta Braves 6-4 on Thursday night.
Young stole five bases in the series as the Mets won two of three from Atlanta.
"He's such a great kid, you root for him all the time, and tonight he showed you he can win games for you," manager Terry Collins said.
Young has joined Curtis Granderson and Juan Lagares in the Mets' outfield. Chris Young could be moving closer to making his return from the disabled list with a right quadriceps injury.
Soon Collins could face difficult decisions in the outfield.
"No question about it," Collins said, adding that Eric Young "makes things happen."
"We saw it tonight," Collins said. "The guy creates runs.
"We talked about it all spring and all winter, what Eric Young brings to the table. When he gets on base he scores runs. He showed it again tonight."
Young had two steals in the Mets' 4-0 win on Tuesday night.
"Anytime you do your job at the top of the lineup, especially with a couple of guys behind me driving me in, it's a lot of fun," Young said.
The Mets broke a 4-all tie in the seventh. Luis Avilan (1-1) gave up a leadoff single to Daniel Murphy, who scored on a two-out single by Juan Lagares off Gus Schlosser. Murphy drove in three runs with three hits.
Carlos Torres (2-0) allowed only one hit in two scoreless innings. Jose Valverde pitched a perfect ninth for his second save.
Led by Young, the Mets stole five bases, their highest total since May 28, 2011, against Philadelphia. Young also used his speed to lead off a two-run third inning with a bunt single.
"Young scored four runs by himself," said Braves manager Fredi Gonzalez, who added, "that pretty much beat us."
Upton drove in three runs with three hits. He had no homers before his breakout game. He hit an opposite-field homer in the second inning before his long two-run blast to left field in the third.
"Tonight I was just comfortable," Upton said. "The only thing I can do is try to take that same exact feel to tomorrow night and the next day and try to make something of it."
Older brother B.J. Upton hit a triple after receiving pregame batting tips from former Braves star Chipper Jones.
Justin Upton's second homer gave the Braves a 4-3 lead.
Mets starter Jenrry Mejia, obviously frustrated, slapped his mitt and then appeared to throw the glove to the grass.
"I just threw my hand up and the glove went out of my hand," he said.
Mejia gave up four runs in five innings on six hits and four walks. Atlanta's David Hale also had control problems as he gave up four runs, three earned, in 4 1-3 innings on five hits and five walks.
The Mets tied the game in the fifth on a leadoff triple by Young and Murphy's single. The Mets loaded the bases on two walks by Hale, but reliever Anthony Varvaro struck out Lagares and ended the inning on Travis d'Arnaud's groundout.
Ike Davis was 0 for 3 with two walks and a RBI in his start at first base. Collins said Lucas Duda, who had a pinch-hit single in the eighth, is still the starter.
Braves shortstop Andrelton Simmons was held out with a jammed right wrist. He said he hurt the wrist in a home-plate collision in Wednesday night's game. He is day to day.
Ramiro Pena, making his first start of the season, replaced Simmons and had one hit.


text:
Stone Flooring
Various Natural stone flooring
Travertine Call our team today on 01756 453354
Submit your review
Submit your review
Our Rhino cleaning power ensures the fastest possible drying time, with encapsulation the drying time is immediate!
We will give you total satisfaction or your money back, guaranteed!
We will move your moveable furniture and carefully put it back when we've finished.
Hassle free, quick, efficient cleaning. Rapid drying times so your room can be used again sooner.
All our technicians are local, friendly, qualified professionals, who respect their customers and value their custom.
We will try to match your preferred cleaning appointment day and date, we work for you, not the other way round.
We promise to do our best job, each and every time we work for you, if it can be cleaned, we will clean it, with a smile.
We will contact you by email, letter or phone with quarterly offers and new services
Fantastic service and great results. Very professional . Thoroughly recommend . An amazing job done on my mother's carpets.
Thanks Michelle, comments like these make our work a pleasure.
Can't believe the results that have been achieved by your carpet cleaning process, the carpets were dry in no time and the clean fresh smell is amazing!
Happy with the service, very smart young Man who came.
Fantastic Carpet Cleaning Service I have ever seen, so professional, so effective, so expertly executed, you have a real gem of a worker in Tom, he's a diamond!
Just had my carpets cleaned throughout in my new property in Kirkby Lonsdale, really good job by Tom and his assistant, really clean and dry in no time at all, and smelling really fresh, good work!
Ask our Technical Expert anything you like
with latest news & offers viaServing all the Yorkshire Dales and beyond
Find out more about our Technical Expert >>
Read more Answers from the Expert >>
Call us now on 01756 453354
email email@example.com
Call 01756 453354
Email firstname.lastname@example.com

subset: commoncrawl


text:
I LOVE this stamp set!! It is so fun and can be mixed and matched with other Lawn Fawn sets. It stamps really nicely and the matching die cuts are a must have!!
Used in this card: Friends Warm the Heart
Cute cute cute!!!
You must be logged in to comment. Please click here to log in.


text:
Searched for: author:"Sun, X."
(1 - 1 of 1)
- document
A nitrogen-doped carbon was synthesized through the pyrolysis of the well-known metal-organic framework ZIF-8, followed by a subsequent acid treatment, and has been applied as a catalyst in the electrochemical reduction of carbon dioxide. The resulting electrode shows Faradaic efficiencies to carbon monoxide as high as ∼78%, with hydrogen...journal article 2018


text:
Jennifer Hudson Whitney Houston Tribute at Grammys (Video)
Jennifer Hudson Sings a Tribute to Whitney Houston
Jennifer Hudson performed "I Will Always Love You" in tribute to the passing of Whitney Houston at last night's Grammy Awards. The emotional in memoriam rendition of Whitney's iconic song came just one day after she passed away suddenly in LA on Saturday. Jennifer's performance was simple and moving — watch it again now.


text:
1. Get Up Close and Personal With the Glorious Costumes of 'Downton Abbey' in the Upcoming 'Costumes of Downton Abbey' Exhibit
From March 2014 to January 2015, a whopping 40 costumes from 'Downton Abbey' will be on display at Delaware's Winterthur Museum, Garden, and Library. Are you as excited as we are? Continue reading


text:
KARACHI - The new playing conditions for Tests, One-day Internationals (ODIs) and Twenty20 Internationals (T20Is) came into effect with the series between Bangladesh and New Zealand, which started in Chittagong on Wednesday.
Conditions will also be applicable in the series between Pakistan and South Africa with first Test starting at Sheikh Zayad Stadium in Abu Dhabi on October 14.
It is important to note that the playing conditions are applicable to international cricket and must be read together with the laws of cricket, ICC announced on Wednesday.
"Whilst a playing condition may affect the laws of cricket as they may apply to international cricket, these changes are not amendments to the laws of cricket themselves," the ICC statement said.
The main amendments to the playing conditions are: Fair and Unfair Play-Changing the Condition of the Ball (Tests, ODIs and T20Is).
Clause 42.1, which deals with the match ball-changing its condition, has been amended to provide clarity in situations where the condition of the match ball has been changed, and the umpires cannot identify the person responsible for changing the condition of the ball.
The following now applies:
If a team has changed the condition of the ball and no player has been witnessed changing the condition of the ball: The ball will be changed, and the captain issued a first and final warning.
Such a warning will apply for the remainder of a Test match, or for the remainder of an ODI or T20I series. If there is a further incident of the condition of the ball being changed, a 5-run penalty will be awarded, the ball changed again and the captain will be held responsible and reported.
If the condition of the ball has been changed and the player responsible can be identified: The ball will be changed, A five-run penalty will be awarded, and the player responsible will be reported.
Decision Review System (Tests): This playing condition has been included in Test matches where DRS is being used on a six-month trial and will expire on April 30, 2014. Each team has a maximum of two unsuccessful player review requests in the first 80 overs of the innings, and a maximum of two unsuccessful player review requests after 80 overs for the remainder of the innings.
This will mean that at the end of the 80th over: a team with two remaining reviews receives no additional reviews, a team with one remaining review receives one additional review, and a team with zero remaining reviews receives two additional reviews.
The ball (ODIs only): Clause 5.1.3 has been added to Law 5 that deals with The Ball. The new clause reads: 5.1.3: "In a match reduced to 25 overs or less per side before the first innings commences, each team shall have only one new ball for its Innings," the statement concluded.


text:
The best street style (so far) at Paris Haute Couture Week
See Gallery
Not to be upstaged by the voluminous shapes, bold embellishments and bright colors seen on the runways of Dior, Giambattista Valli and more during the haute couture shows this week, the streets of Paris themselves are playing host to their own parade of oversized coats and feminine dresses in curious colors.
From tea length frocks and skirts to sweetheart necklines, there's been a recognizable nod to feminine shapes and cuts that accentuate classic beauty. And we're into it.
Check out the slideshow above to see the best Parisian street style from Haute Couture Week!
More from Fashionista:
Bongo releases un-retouched ad campaign starring Vanessa Hudgens
Giorgio Armani does shorts for couture
Kim Kardashian gets another fashion stamp of approval at Valentino


text:
U.S. Equal Employment
Opportunity Commission
HOUSTON - JC Wings Enterprises, LLC, doing business as Bayou City Wings, a Baytown-based restaurant chain, violated federal law when its managers laid off pregnant employees under a discriminatory policy, the U.S. Equal Employment Opportunity Commission (EEOC) charged in a lawsuit it filed today.
According to the EEOC's lawsuit, Maryann Castillo and other female workers were laid off after the third month of their pregnancies under a written policy, set out in Bayou City Wings' employee handbook. Bayou City Wings owns and operates restaurants in Baytown, Houston and surrounding areas. The company's district manager laid off Castillo pursuant to the policy even though she had provided a doctor's note that indicated she could work up to the 36th week of her pregnancy and that her doctor had not placed any restrictions on her ability to work.
During the EEOC's investigation of a discrimination charge brought by Castillo, Bayou City Wings named eight female employees who were laid off from work because of their pregnancies. According to a Bayou City Wings general store manager, for a manager to keep a pregnant employee at work any longer would "be irresponsible in respect to her child's safety" and would jeopardize his position with the company "for not following procedures."
Title VII of the Civil Rights Act of 1964, as amended by the Pregnancy Discrimination Act, prohibits employers from discriminating against employees on the basis of sex or pregnancy. The EEOC filed suit (Civil Action No. 4:12-cv-02885) in U.S. District Court for the Southern District of Texas, Houston Division, after first attempting to reach a pre-litigation settlement through its conciliation process. The EEOC seeks an injunction, back pay with pre-judgment interest, reinstatement or front pay, compensatory damages and punitive damages, in amounts to be determined at trial
"Federal law protects the right of a woman to remain gainfully employed during her pregnancy," stated Martin Ebel, deputy district director and acting district director for the EEOC's Houston District Office. "An employer cannot dictate, out of a desire to protect a pregnant employee or for any other reason, whether a female employee continues to work during her pregnancy."
Jim Sacher, the EEOC's regional attorney in Houston, explained, "The Supreme Court has made clear that the decision whether a pregnant woman should work rests solely with her. She alone, and not the employer, is responsible for making decisions that affect her safety and that of her child. An employer's policy which forces leave on a pregnant employee is exactly the type of conduct the Supreme Court has found to be unlawful."
The EEOC enforces federal laws prohibiting employment discrimination. Further information about the EEOC and the laws it enforces is available on the agency's web site at www.eeoc.gov.


text:
Best Practices
Edward J. Mullen, Jennifer L. Bellamy, and Sarah E. Bledsoe
This entry describes best practices as these are used in social work. The term best practices originated in the organizational management literature in the context of performance measurement and quality improvement where best practices are defined as the preferred technique or approach for achieving a valued outcome. Identification of best practices requires measurement, benchmarking, and identification of processes that result in better outcomes. The identification of best practices requires that organizations put in place quality data collection systems, quality improvement processes, and methods for analyzing and benchmarking pooled provider data. Through this process, organizational learning and organizational performance can be improved.
Contexts/Settings: Private/Independent Practice Settings
Sandra A. Lopez
Private independent practice (known historically as private practice) is a growing segment of the social work profession. Social workers entering this context are providing a range of services, including clinical and nonclinical. Major considerations for establishing, maintaining, and marketing a successful and ethical private independent practice will be discussed. Existing tensions and challenges in the social work profession and in the field of social work education will be briefly examined. Future directions for private independent practice of social work will be explored.
Employee Assistance Programs
Sheila H. Akabas
Employee assistance programs (EAPs), or membership assistance programs when sponsored by unions, are designed to improve worker productivity and motivation by responding to problems that workers experience which interfere with job performance and satisfaction. Now a ubiquitous characteristic of American workplaces, the programs are largely staffed by social workers. This entry discusses their historic development, extent, scope, structure, how they are perceived and utilized by different racial and gender populations, and the dilemmas and challenges facing EAPs as they try to define their role, function, and best practices amid emerging trends in the world of work.
Management: Practice Interventions
Kristina Jaskyte
This entry reviews major intraorganizational and extraorganizational management strategies found in the prescriptive as well as empirically based literature that promote organizational effectiveness and responsiveness to clients. Obtaining support and stakeholder management constitute two major areas for extraorganizational practices.
Among the most often discussed targets for intraorganizational management interventions are leadership practices, board practices, organizational culture, organizational structure, and worker attitudes.
Management: Human Resources
Michàlle E. Mor Barak and Dnika Jones Travis
Social work organizations depend on a well-trained and responsive workforce to provide quality services. Human resource management (HRM) refers to the design of formal systems that ensure effective and efficient use of human talent, and serves as a vehicle to accomplish organizational goals. Effective HRM requires applying the same person-in-environment value orientation that guides client services to managing human resources. Considering the complexity of HRM, we have developed an organizing framework focused on employee development, organizational effectiveness, and cross-cutting HRM issues. In today's economic, legal, cultural and technological environment that emphasizes accountability, effective management of human talent is critical.
Outcome Measures in Human Services
Jennifer L. Magnabosco
Throughout history, measuring outcomes has been a goal and priority in the human services. This entry chronicles the history of outcomes measurement in the human services in the United States and discusses present-day outcome measurement activities as well as trends and some of the key areas for outcomes measurement in several human service domains.
Lawrence Shulman
Supervision of students and practitioners has been important to social work since its earliest evolution as a recognized profession. Central to the process is the idea of one professional with more knowledge, skill, and experience guiding the practice and development of another with less. The four content areas of supervision usually include direct practice, professional impact, job management, and continued learning. There are a number of supervision models, and most emphasize a positive supervisor–supervisee working relationship, a parallel process, and the importance of cultural competency. The emergence of Evidence-Based Practices and Trauma-Informed Practices has also influenced supervision. The contemporary context of social work supervision offers both opportunities and challenges to clinical supervision.
Technology: Technology in Micro Practice
Jerry Finn
Online therapy is the delivery of supportive and therapeutic services over the Internet. Online therapy offers the advantages of convenience and increased access to services. Service delivery may be problematic due to ethical concerns and legal liability. Limited research supports the efficacy of online therapy for a variety of health and social concerns. Increased use of the Internet by consumers and human service agencies will likely see growing use of online therapy and require training for workers and development of new policies and procedures for online service delivery.
Vocational Services
Lauren B. Gates
Vocational rehabilitation (VR) services, provided through a jointly funded state–federal rehabilitation system and available in each state, help people with disabilities prepare for, secure, and sustain employment. Since 1920, VR Programs have helped 10 million individuals with disabilities reach employment. Anyone with a mental or physical disability is eligible for VR services. While a range of services is provided, the services most consistent with VR goals are those, such as supported employment, that promote full integration into community life. Social workers are essential to community-based VR services; however, a challenge for the profession is to assume new roles to meet best practice vocational standards.


text:
Berkeley Medical Malpractice Attorneys
It is everyone's worst nightmare; you have sought medical intervention. Perhaps you need a fairly common surgery or maybe you are bringing a new life into the world; you trust the medical professionals who are caring for you. All it takes is one moment and a careless physician, inattentive nurse, or overworked technician can alter your life, perhaps forever. This is not the time to go it alone or trust that insurance companies are looking out for your best interests. This is the time when you need the support and protection of a team of experienced professionals; this is the time that you need the Berkeley medical malpractice attorneys at Mary Alexander & Associates.
Here at the Berkeley-based law firm of Mary Alexander & Associates, we are in the business of righting wrongs and attaining compensation for victims of medical malpractice; something that we have successfully done for the past 30 years. Our highly trained staff of professionals knows how to navigate the frustrating world of medical malpractice and we know how to get the results that you, the helpless victim deserve.We provide assistance from skilled representatives with medical backgrounds that understand how things should be done.
We understand the fact that the medical world is an intimidating place. It is easy to feel alone and outmatched when taking on huge medical corporations and insurance companies. That is why we are here for you. Our courtroom success record and tradition of excellence are sources of pride here at Mary Alexander and Associates. Preparing thoroughly for trial is the trademark of our firm, and we build innovative courtroom exhibits and technology to help juries understand even the most complex legal matters. Our innovations, creativity, and preparation have allowed us to achieve an outstanding record of success. We are justifiably proud of the verdicts and settlements we have obtained for our deserving clients.
Winning our cases is an important part of our work here, but we believe winning the trust and the respect of our clients is every bit as important as our work in the courtroom. We understand that the people who come to us are suffering and we know that the suffering is not their fault. No one asks to be the victim of medical malpractice; we understand that our clients look to us as advisors and as advocates during a painful and bewildering point in their lives. We take pride in knowing that we are going the extra mile every day to be sure that our clients and their needs are front and center and that we are available when they need us.
Consult Our Berkeley Medical Malpractice Attorneys
Often, we hear about people who have suffered needlessly and are having their suffering compounded by attempting to get the compensation they deserve on their own. The reason given is usually something similar to the phrase "I can't afford a lawyer." All attorneys at Mary Alexander & Associates take their clients on a contingency basis. So if for some reason you do not receive compensation, we will charge no fees. Navigating the world of medical malpractice is difficult at best, but you do not have to struggle alone. If you or someone you know is the victim of medical malpractice, call our Berkeley medical malpractice attorneys at 415-433-4440. We are on your side and by your side through the whole process; getting you the compensation that you deserve.


text:
Q&A With Junior Erik Elliott
Related Links
Playing as the third seed in the West Region, the UC San Diego men's tennis team will make its 11th-straight NCAA postseason appearance on Thursday with a 9:30 a.m. road match against BYU-Hawaii. The Tritons have already met the second-seeded Seasiders twice this season, suffering losses by 5-4 and 7-2 scores. If UCSD can snag a win in its third attempt, the team will join 15 other squads in Altamonte Springs, Fla., for the final rounds of competition.
Leading the Tritons in singles is Erik Elliott, a junior out of San Juan Capistrano, Calif. After only competing in doubles as a sophomore, Elliott has stepped into the No. 1 singles spot this season and performed admirably. He has produced a singles record of 9-6 to go along with a team-high 13 doubles victories, while being paired with Jake Fellow earlier in the season and Chapman Chan more recently.
Before jetting off to Hawaii for Thursday's big match, Elliott took a few moments to discuss the team's success this season, his three years as a Triton and the preparations he's making for his third meeting of 2010 with BYUH's top player, Rong Ma.
Q: Your team traveled to Hawaii earlier in the season for three matches. How is this trip to the island different and do you expect any changes in the squad's attitude?
ELLIOTT: This trip is a little different in that we are playing in order to go to nationals. Our last trip was for experience playing there and playing some teams in our conference to figure out the seeding. That being said, every match is important though and this match is equally important. This time, we're a little more relaxed since it's only one match to focus on. Instead of three teams we have to think about, it's only one team to prepare for. I think our team is really excited to be going back to Hawaii and probably feeling a little more comfortable and prepared this time.
Q: Thursday will mark the third time you'll face Ma this season. Can you talk a little bit about his style of play and what you need to do to win that singles match?
ELLIOTT: Rong is different from a lot of the guys I play because he uses his head a lot more than others. He always makes smart choices and that comes from experience. He's 26 years old and the court experience he brings to every match definitely shows. He's strong off of both sides and has a great all-around game. Nothing really stands out about his game, but there aren't really any obvious weaknesses either. In order to beat him, I have to play a little differently than most people. Most of the guys I play, I can expect them to make random mistakes or give me free points. I can't expect that as much from Rong. In order to beat him, I will have to realize that I will need to set up the points much longer and better in order to finish the point. I will have to expect every ball to come back and come back well.
Q: After keeping to just doubles last year, how challenging has it been to take on the No. 1 singles spot from the start of 2010?
ELLIOTT: It's definitely been a challenge. At the beginning of the season, I knew it was going to be tough and honestly it's been even harder than I expected. I did get the chance to play a few singles matches at the five and six positions my first two years and coming from that was a big surprise. My first match this year was a big eye opener for me. We played the University of San Diego and I was not at all prepared for the level of play at No. 1. I got blown away by Dean Jackson and was basically shocked and not prepared at all for that. I remember that day I stayed for an extra two hours after the match was over and trained with my personal coach because I felt like I just wasn't mentally prepared for that level of play. The next week I came out and was much more prepared to take on the No. 1 spot.
Q: A lot of teams go through transformations during the three or four months of the season. How have the Tritons changed since that season opener on Feb. 1?
ELLIOTT: We've changed a lot. A lot of guys of the team have been working hard this year and it's really shown. Even during season, some people have really stepped up their games and started playing at much higher levels than when we started. Our lineup and doubles teams have changed a few times as a result.
Q: Seeing that your father was a Division I national champion in alpine skiing at the University of Colorado, I'm sure you know a thing or two about winter sports. What's your favorite Olympic moment?
ELLIOTT: I enjoyed watching all of the winter Olympic games. I can't really pick a favorite as there were a lot of good moments. Except for curling. I can't really get excited watching curling.
Q: Other than tennis, what sports did you enjoy playing as a child?
ELLIOTT: I did a lot of skiing when I was younger. I lived in Colorado until I was five, and skied over 100 days a year while I was there. My dad had me standing on skis at 13 months old. We moved to California when I was five though and since then it has been tennis. I used to play some soccer and take swim lessons but tennis pretty much became my sole sport at seven years old, when I started playing every day.
Q: Having spent countless hours on the road and on the courts with your teammates this season, you probably are a fair judge of their talents. If one of them could serve as President of our country for a week, who would you elect?
ELLIOTT: Jason Wall. I feel like he would try his best to do the most for our country in a week.
Q: The ESPN tennis crew of Dick Enberg, Mary Jo Fernandez and Patrick McEnroe is out with food poisoning after eating alligator in the outback. They need a fill-in for the final of the Australian Open and want one of your teammates. Who would do the best job?
ELLIOTT: It would have to be a duo, Chapman Chan and Sam Ling would be hilarious.
Q: Out of all the teams at UCSD, what's your favorite sport to watch besides tennis?
ELLIOTT: Water polo and volleyball because they are both really exciting for spectators.
Previous Q & A Articles
Kelly Fogarty (Women's Track & Field) April 23, 2010
Liz LaPlante (Women's Tennis Head Coach) April 15, 2010
Kirby St. John (Baseball) March 24, 2010
Dan Perdew (Men's Swimming) February 28, 2010
Calvin Ross (Men's Volleyball) February 20, 2010
Nicole Saari (Softball) February 4, 2010
Brad Kreutzkamp (Women's Water Polo Head Coach) January 18, 2010
Tyler Acevedo (Men's Basketball) January 4, 2010
Dr. Cliff Kubiak (UCSD's Faculty Athletic Rep) December 18, 2009
Chelsea Carlisle (Women's Basketball) December 9, 2009
Carianne Cunningham (Women's Swimming) November 23, 2009
Elena Inouye (Cross Country) November 6, 2009
David Morton (Men's Water Polo) October 28, 2009
Juan Pablo Carillo (Men's Swimming) October 19, 2009
Sara Spaventa (Women's Soccer) October 10, 2009
Karen Reis (Women's Volleyball) October 2, 2009
Daniel Pavitt (Men's Soccer) September 23, 2009
Daniel Anderson (Cross Country) September 11, 2009
Peter Gresham (Men's Water Polo) September 2, 2009
Alexia Zatarain (Women's Soccer) August 24, 2009
Elaine Chen (Women's Volleyball) August 12, 2009
Jared Kukura (Men's Soccer) July 30, 2009
Dawn Lee (Former Women's Soccer Standout) July 8, 2009
Rob Mamula (Director of Athletic Performance) June 18, 2009
Garrett Imeson (Baseball) June 8, 2009
Leon Baham (Men's Track & Field) May 21, 2009
Kristyn Lesovsky (Softball) May 8, 2009
Kazumi Negishi (Men's Tennis) May 5, 2009
Laiah Blue (Women's Track & Field) April 16, 2009
Ryan Andre (Men's Crew) April 2, 2009
Josh Tanner (Baseball) March 24, 2009
Anju Shimura (Women's Swimming) March 7, 2009
Stephanie Bocian (Women's Water Polo) February 20, 2009
Lauren Chastain (Softball) February 5, 2009
A.J. Maulhardt (Men's Basketball) January 28, 2009
Annette Ilg (Women's Basketball) January 22, 2009
Steven Hardy (Men's Swimming) January 13, 2009


text:
Julian Gomez-Cambronero, PhD
Signal Transduction in Blood Cells, Normal and Leukemic
Principal investigator:
Julian G. Cambronero, Ph.D.
Brage Golding Distinguished Professor of Research,
Department of Biochemistry & Molecular Biology
Director, Hematology Course
Boonshoft School of Medicine
Wright State University
Phone: (937) 775-3601
PubMed search: Julian Gomez-Cambronero
Laboratory members:
Karen Henkels (Research Associate)
Kristen Fite (M.D./Ph.D. student)
Madhu Mahankali (Postdoctoral fellow)
Ramya Ganesan (M.S. student)
Samuel Frank (Ph.D. student)
Francis Speranza (Honors thesis)
Elizabeth Mallets (Honors thesis)
Taylor Miller (Graduate Student)
Denise Kramer (Ph.D. Student)
- Gregory Stahl, Ph.D. (Harvard Medical School, MA)
- Charles Serhan Ph.D. (Harvard Medical School, MA)
- Bruce Levy, M.D., Ph.D. (Harvard Medical School, MA)
- Dianne Cox, Ph.D. (Albert Einstein College of Medicine, NY)
- Mary C. Dinauer, M.D., Ph.D. (Washington University in St. Louis, MO)
- Joel Sawnson, Ph.D. (University of Michigan Medical School, MI)
- Gerald Alter, Ph.D. (Wright State University, OH)
- Michael A. Frohman, M.D., Ph.D. (SUNY Stony Brook, NY)
Douglas Joseph, Tameka Hayes, Yu-Hua Shang, Jeff Horn, Brooke Andrews, Jason Lehman, Jeff Taylor, Kara Duffy, Amy Price, George Auzani, Laurie Bromagen, Amy Dugan, Stephanie Carter, Kristina Bond, Isabel Campos, Kelly Robins, Tricia Frye, Stacy McMahon, Valerio Barauna, Mauricio Di Fulvio, Jennifer Hollyfield, Nicholas Lehman, Nick McCray, Marzena Buzanowska, Xiao Li, Farnaz Tabatabaian, Hong-Juan (Floria) Peng, Marium Husan, Kathleen Frondorf, Allissa Blystone, Kevin Daughtery, Katie Knapek, Jennalie Post, Erin Lintz, Steven Short, Terry Farkaly, Nathaniel Hatton.
More photos at the very end of this webpage >>>
Julian G. Cambronero, Ph.D., was awarded the title of "Honorary Professor" at Southern Medical University in Guangzhou, China, on April 10, 2012, for his international standing as a leader in cell signaling. Read about it here.
Dr. Gomez-Cambronero presents workshop on
"How to Write Your First Grant"
Dr. Julian Gomez-Cambronero, chair of the Professional Development Committee of the Society for Leukocyte Biology (SLB), has organized Grant Writing Workshops at the SLB Annual Meetings in Kansas City, Missouri; Maui, Hawaii; Newport, Rhode Island; Salt Lake City, Utah. Click here to view the PowerPoint slides with lots of useful advice.
Additionally, the panelists have published a paper in Nature Immunology describing the content of the workshop, along with a compilation of tried-and-true tips. Although intended for junior investigators, the paper could also be of help for investigators at other stages. Click here to view the paper.
Articles & News Releases
- Vital Signs article: "Mechanisms to Slow Tumor Growth", Spring 2014
- News Release: "Dr. Cambronero recognized with prestigious Award in Spain", Sept. 12, 2014
- News Release: "Boonshoft School of Medicine professor organizes international conference on inflammation and cancer," Jan. 15, 2014
- Beavercreek News-Current story: "WSU local doctor part of publishing medical research data," December 2013
- News Release: "Wright State University names Julian G. Cambronero, Ph.D., Brage Golding Distinguished Professor of Research," Sept. 13, 2013
- News Release: Julian Gomez-Cambronero named Brage Golding Distinguished Professor of Research August 6, 2013
- News release: "Wright State researcher discovers mechanism to slow tumor growth and metastasis in breast cancer," July 2, 2013.
- News release: "Tribute Given to Dr. Gomez-Cambronero," March 2, 2005.
- News release: "Julian Gomez-Cambronero at the Forefront of a New Field," March 21, 2004.
- Vital Signs article: "Researchers Seek to Unravel a Central Paradigm in Cell Biology," Fall 2004.
A native of Spain, Dr. Julian Gomez-Cambronero received his Ph.D. (cum laude) in Biochemistry and Immunology at the Complutense University (Madrid, Spain) under Dr. M. Sanchez Crespo and Dr. J. M. Mato direction. He then moved to the United States and completed his training in Cell Biology as a postdoctoral fellow in Dr. R. I. Sha'afi's laboratory at the Department of Physiology of the University of Connecticut Health Center, and with the late Dr. E. L. Becker. From 1991 to 1995 he was part of the faculty at the University of Connecticut, first as an Instructor and then as a Research Assistant Professor. In 1995 he moved to the Department of Physiology and Biophysics at Wright State University, chaired by Dr. P.K. Lauf, to accept a tenure-track Assistant Professorship position, and was promoted to Associate Professor in 2000 and to full Professor in 2004. He is married to Teresa Madrid and has two children, David and Julia.
Member of the graduate program
As part of the graduate faculty and as a dissertation-qualified professor, he participates in the following areas of concentration of the Biomedical Sciences Ph.D. Program: Cell Biology and Physiology, Immunology, and Biochemistry and Molecular Biology. He also participates in the Master of Science in Physiology and Neurosciences Programand the Master of Science in Microbiology and Immunology Program. His formal lectures include an "Introduction to Hematology" series for first-year medical students in the team-taught Molecular, Cellular and Tissue Biology course; "Molecular Basis of Leukemia and Lymphoma" series for second-year medical students; and "Signal Transduction/Molecular Endocrinology and Blood Physiology" series for the Biomedical Sciences Ph.D. Program. He is course director for "Hematology" for the Boonshoft School of Medicine and was course director for "Molecular and Cellular Signaling" for the Biomedical Sciences Ph.D. Program.
Honors and awards
Dr. Cambronero is a member of the American Society for Biochemistry and Molecular Biology, the American Society of Hematology, and the Society for Leukocyte Biology. He was part of the Leukemia Society of America (LSA) Northern Connecticut Chapter Telecast in 1990; was National Finalist for the Young Investigator Award of the Society for Leukocyte Biology (SLB) in 1992; received the New Investigator Research Award from the Donaghue Medical Research Foundation in 1992; was elected as Expert Scientist by the Farmington, Connecticut, Public School Board to evaluate the science curriculum in 1994; was the subject of a biographical record in the American Men & Women of Science directory in 1995; received the Frontiers in Physiology National Research Award from the American Physiological Society (APS) in 1996; was recognized with the STARS Scholar Distinguished Service Award by The Ohio University in 1998; received the Professional Achievement "Sembrador" Award from The City of Manzanares (CR), Spain, in 2004; and received the Outstanding Achievement in Medical Education and Research Award from the Academy of Medicine of Dayton in 2007. He was named Honorary Professor at Southern Medical University, Guangzhou, China, in 2012. The Wright State University Board of Trustees awarded him the title of Brage Golding Distinguished Professor of Research in 2013. Recieved the title of "Hijo Predilecto" from his hometown in Spain in 2014.
Funding and scholarly publications
Dr. Cambronero has received funding from the National Institutes of Health (NIH NHLBI); the American Cancer Society (ACS); the American Heart Association (National Program); the American Physiological Society; the Ohio Board of Regents; the University of Connecticut; and Wright State University.
He was part of the NIH study sections: Erythrocyte and Leukocyte Biology (ELB), and Cell Development and Function (CDF-2). He is a permanent member of Innate Immunity and Inflammation (III) NIH Study Sections and the Molecular Signaling, Basic Cell and Molecular Biology for the American Heart Association (AHA) Research Consortium.
He has published more than 100 original research papers in peer-review journals (PubMed name: Gomez-Cambronero, J.), and has presented widely nationally and internationally to Research conferences and universities. He has also published science-fiction short stories and layman science-related articles in Spanish literary magazines.
Organizing a grant-writing workshop
Dr. Cambronero is the chair of the Professional Development Committee of the Society of Leukocyte Biology (SLB) whose mission is to provide educational opportunities for junior scientists and immunologists. He developed and organized the Annual Workshop on "How to Write Your First Research Grant" with advice for grad students and junior professors on grantsmanship for NIH grants, which was held in Kansas City, Mo., (September 2011), Maui, Hawaii (November 2012), Newport, Rhode Island (Ocotober 2014) and Salt Lake City, Utah (October 2014).
- Writing a First Grant Proposal — Society for Leukocyte Biology (PDF)
- "How to Write Your First Research Grant" Workshop — Society for Leukocyte Biology (PPT)
Making science available to the general public
Dr. Cambronero came up with the idea and designed el Paseo del Sistema Solar (A walk through the Solar System) in the City of Manzanares (Castilla-La Mancha, Spain). It is a scale model of the Solar System, where representations of the Sun and the planets have been positioned along a path throughout a public park, according to a scale that reduces the millions of miles in the cosmos down to yards in the park. The actual representations of the Sun and planets are spheres constructed of fiberglass, set within rectangular prisms or "monoliths" of oxidized steel, measuring about six feet tall each. The objective of the "Paseo del Sistema Solar" is for the visitor to gain an understanding and appreciation of the workings of the Solar System in a "hands-on," "walk-through" model. Dr. Cambronero wanted to make sure that science is explained and made available to the general public. He hopes this project particularly reaches the younger generations, encouraging them to become interested in the wonders of science. Visit http://www.paseodelsistemasolar.manzanares.es for more information, or click here for a summary in English.
Univ Complutense Madrid, Spain; Biochemistry, PhD (cum laude), 1986
Univ Connecticut Health Center, Farmington, CT; Cell Biology Postdoc, 1987-90
Smith College, Dept Biology, Northampton, MA; Genomic DNA, cDNA cloning, 1997
Smith College, Dept Biology, Northampton, MA; Q-PCR, SNP, RNA silencing, 2004
Positions and Employment:
- UCONN Health Center, Medical School Instructor 1991-92
- UCONN Health Center, Medical School Research Assistant Professor 1992-95
- Wright State University School of Medicine Assistant Professor 1995-00
- Wright State University School of Medicine Associate Professor (tenured) 2000-04
- Wright State University School of Medicine Professor (tenured) 2004-present
- University Indianapolis School of Medicine Visiting Professor (M Dinauer's lab) 2006
- Harvard Medical University (Brigham&Women's) Visiting Professor (G Stahl/C Serhan/B Levy) 2015-16
- Director, Hematology, School of Medicine
- Cell, Tissues and Organs (Blood), School of Medicine
- Cellular and Molecular Signaling, Graduate School
- Molecular Biology of the Nucleus, Graduate School
- Molecular Basis of Inherited Diseases, Graduate School
Our laboratory studies the molecular basis of cell migration during inflammation and cancer metastasis
- Inflammation. We study the molecular basis of cell migration trying to understand what causes the abnormal behavior of highly motile cells. A class of such cells are the white blood cells (leukocytes, such as neutrophils and macrophages). In humans and other mammals, leukocytes circulating freely in the blood migrate to an open wound to defend us against an infection from germs. This is a vital and desirable function of the organism.
However, in other cases, leukocytes arrive in large numbers to the wrong place at the wrong time. Such is the case that follows a heart attack. In the condition named "ischemia-reperfusion injury," if the blood flow is restored after the attack, then leukocytes are recruited at the heart where they can inflict great damage in healthy tissue, making the situation even worse than when it started.
- Cancer. Another aspect of cell migration that has clear and important pathological implications is in cancer metastasis. Cancer cells escape the initial tumor when the tumor reaches a certain size, becoming invasive and highly motile, and get into the systemic circulation by reaching a nearby capillary or lymph vessel. They are transported to other locations in the body to start new cancer colonies. We are applying our knowledge gained from studying leukocyte chemotaxis to the migration and tissue invasion of breast cancer cells, since in the epithelial-to-mesenchymal transition they become ameboid, free-floating and highly mobile like them.
- Inhibitors. We have discovered a variety of signaling molecules that include tyrosine kinases (JAK3 and the oncogene Fes), small GTPases (like Rac2) and lipases (phospholipase D) that are crucial for controlling the intracellular process of cell migration. Our idea is to devise ways to target those signaling pathways with specific chemical compounds (inhibitors), which could stop metastatic breast cancer cells or derail leukocytes from damaging the heart.
- Signaling Pathways. At the molecular level, we are clarifying cell-signaling pathways in an ever-expanding network in which Phospholipase D (PLD) has turned out to participate. There are protein-protein associations of PLD2 with motile proteins (Rac and WASP) or with tyrosine kinases. These signaling molecules are interdependent: if you remove the one, the other will be affected. It is very challenging to tease apart the extensive networks that are so intricately linked, but we have made important strides in elucidating these new pathways.
The targeted cell signaling molecules for current studies are: the kinases mTOR, S6K, JAK3 and oncogene product FES; the GTPases Rho and Rac2 and their GEF's; the SH2/SH3-bearing protein Grb2; WASP, actin, tubulin, Filamin and Arp2/3 motile proteins; human PLD1 and PLD2; and Aurora Kinase.
- Techniques. Dr. Cambronero's team uses molecular and cell biology methods, such as in vitro differentiation of bone marrow progenitor cells, gene transduction, transgenic in vivo models, immunofluorescence, confocal and FRET microscopy, DNA cloning of fluorescent chimeras, analysis of gene expression by quantitative RT-PCR, site directed mutagenesis, RNA silencing and proteomics methodologies.
- Funding. Funding for Dr. Cambronero's lab is being provided by the National Institutes of Health (NIH)-National Heart Lung and Blood Institute (NHBLI); the American Heart Association (Great Rivers Chapter); American Cancer Society (ACS); Ohio board of Regents; and Boonshoft School of Medicine.
Major Research Accomplishments
- The discovery for the first time that a hematopoetic growth factor (GM-CSF) plays a key role as a chemoattractant for neutrophils involving ribosomal S6K phoshorylation. The importance is that local GM-CSF promotes wound healing (Gomez-Cambronero et al, J Immunol 2003; Gomez-Cambronero et al, FEBS Lett 2003).
- The discovery of new molecular cooperation in cell signaling mechanisms: Dual phosphorylation of S6K by MAPK-mTOR at separate amino acid targets (Horn et al, J Biol Chem 2003). A second messenger (phosphatidic acid, PA) that serves as a nexus for bringing together molecules of disparate activities (phospholipase PLD and kinase S6K) (Lehman et al, FASEB J 2007). We went further on discovering that PA, as a product of bacterial metabolism, is a chemoattractant for neutrophils, and we uncovered its mechanism of action (Frondorf et al, J Biol Chem 2010), explaining the advantage to leukocytes in a host-microbe immune interaction.
- The discovery for the first time that PLD has a previously unknown function: that of regulating leukocyte cell migration, which plays a role during the inflammatory response (Lehman et al, Blood 2006).
- The uncovering of a novel regulatory molecule for PLD, Grb2, that for the first time was implicated in PLD2 signaling. Grb2 through its SH2 domain in turn binds to Sos (DiFulvio et al, Oncogene 2006). The recognition that PLD mutants on SH2 target sites, affect DNA synthesis (DiFulvio et al, Mol Biol 2007) and PI3K/Akt mobilization (DiFulvio et al, Cell Signaling 2008). The novel interaction PLD2-Grb2-Sos has been highlighted in "News and Views" Hancok, J.F. (2007) "PA promoted to Manager" Nature Cell Biol 9, 615-17 (see below).
- Our laboratory has uncovered the precise molecular mechanisms of activation of the signaling molecule PLD2 and the exact sites of interaction with other molecules. This involves its PH and PX regulatory domains, JAK3, Src, EGR tyrosine kinases and GTPases (Rac2) (Henkels et al, Mol Cell Biol 2010; Tabatabaian et al, J Biol Chem 2010; Peng et al, J Biol Chem 2011; Peng et al, Mol Cell Biol 2011). The implication of this precise regulation has bearings on leukocyte migration/inflammation. Further, we have implicated for the first time the combined action of JAK3/PLD2 on Y415 residue, that could be a novel target to inhibit cell invasion of highly metastatic breast cancer cells (Henkels et al, J Mol Biol 2011).
- We have elucidated the transcriptional regulation of lipases and kinases mTOR/S6K during differentiation of proleukemic cells discovering that mTOR keeps PLD under transcriptional repression (Tabatabaian et al, J Biol Chem 2009). Further, we have demonstrated that PLD shortens the differentiation time of cells becoming mature neutrophils. Achieving a shortened time is highly beneficial for the induction therapy of acute myelocytic leukemia patients (DiFulvio et al, J Biol Chem 2011).
- We have demonstrated how PLD recruits the motility protein "WASp" to the cell membrane accumulating in nascent phagocytic cups, its visualization and subsequent activation, which has allowed us to explain the initial molecular mechanism of phagocytosis of macrophages (Kantonen et al, Mol Cell Biol 2011) and the sequence of activation of the lipase with cell movement: PLD2-Grb2-WASp-Arp3-Actin, mediated by Phosphatidic Acid (PA) (Speranza et al, J Biol Chem 2014).
- We have provided the groundbreaking evidence demonstrating for the first time that a phospholipase can act as a GTPase exchange factor (GEF), the first in its class (Mahankali et al, PNAS 2011), and have uncovered the catalytic site of the enzymatic activity (Mahankali et al, JOCES 2013; Ye at el, J Biol Chem 2013).
- PLD is crucial for tumor growth and metastasis of breast cancer, demonstrated in vivo (mice models) (Henkels et al, Oncogene, 2013).
- We have reported that profound changes in the morphology of leukocytes (from spherical to stellated) and cancer cells are due, in part, to an overactivation of the kinase S6K, in a role unrelated to ribosome regulation (Henkels et al, FASEB J 2014). Likewise, we have described a new, non-mitotic role for Aurora Kinase A as a direct activator of cell migration (Mahankali et al, J Cell Sci. 2014).
A Gallery of Signaling Models
1. Model of WASp activation during leukocyte phagocytosis. WASp is activated via two alternative pathways, a PLD2-mediated pathway and a Grb2-mediated pathway. First, PLD2 catalysis of phosphatidylcholine (PC) via its two HKD lipase domains activates PI5K through PA, a product of PLD2. As a downstream product of PI5K, WASp is activated by the subsequent PIP2 produced by PI5K. Alternatively, Grb2 interacts with WASp polyprolinea through its two SH3 domains, leading to nucleation of actin filaments and to the formation of filopodia. Kantonen S, et al (2011) Mol Cell Biol 31, 4524-37.
2. GEF activity sites in PLD2 and mechanism of action. (A-B) Proposed catalytic sites of PLD2's GEF activity according to this study. (C) Mechanism of PLD2-mediated nucleotide exchange. Key residues on PLD2, phenylalanine 129, leucine 166, phenylalanine 107 and leucine 173, are shown as part of the catalytic site that form a hydrophobic pocket. (C) Rac2 holds onto GDP with its switch I and II domains. PLD2 and Rac2 forms a complex. Mahankali M, et al (2012) J Biol Chem 287, 41417-31.
3. A switch between two enzymatic activities in the same molecule. At early times of cell stimulation both PA and Rac2-GTP are produced to begin chemotaxis. Accumulation of Rac2-GTP negatively feeds back on PLD2-lipase activity. JAK3 tyrosine kinase restores lipase activity while inhibiting GEF activity. (4) At later times, lipase predominates and GEF is further inhibited. Mahankali et al (2103) J Cell Science PMID:23378025.
4. Interplay between phosphatidic acid (PA) and Fes and JAK3 kinases with a PA sensor in breast cancer cells. MCF10A and MDA-MB-231 transfected with Fes plasmid and the EGFP-based PA sensor plasmid. Green denotes the EGFP-tagged PA sensor. Red denotes the TRITC-tagged Fes. Blue denotes DAPI staining of the nucleus. A significant increase in endogenous PA was seen co-expressing with Fes and an intracellular translocation is also detected. Ye Q, et al (2013) J Biol Chem.
5. A new JAK3-Fes-PLD2 pathway responsible for the invasive and highly proliferative phenotype of breast cancer cells. It involves two tyrosine kinases, JAK3 and oncogene Fes, as well as phospholipase D. Protein-protein interactions through SH2 motifs and activation by phosphatidic acid (PA) provide a positive activation loop between the 3 molecules, that is absent in non-transformed, normal cells. Ye Q, et al (2013) J Biol Chem.
Journal Reviewer: Editorial Member, Journal of Biological Chemistry (2015-2020)
Ad hoc for: J Hematology; Am J Physiology; Biochemistry; Biochim Biophys Acta; FEBS Letters; J Cell Physiol; J Chemical Ed; J Clinical Investigation; J Histochem Cytochem; Mediators of Inflammation; J Immunol Methods; J Immunol; J. Leukocyte Biol; FASEB J; J Lipid Research; Gene; Cell Signaling; PLoS ONE; Blood; J Biol Chem; Biochem J; Mol Cell Biol; PNAS; Cancer Research; Cancer Letters; Oncogene; Nature Chemical Biology; Nature Cell Biology.
Grant Reviewer:
- NIH Ad hoc, Erythrocyte and Leukocyte Biology (ELB) study section, 2004
- NIH Ad hoc, Cell Development&Function (CDF-2), 2004; Innate Immunity and Inflammation (III) 2005
- AHA, Full Member Reviewer, Molecular Signaling, Basic Cell /Mol Bio study section, 2005-09
- National Science Foundation (NSF) Ad hoc, 2003, 2010, 2012, 2013
- NIH, Full Member Reviewer, Innate Immunity and Inflammation (III) study section, 2010-13
- NIH Special Emphasis Panels: ZRG1 CB-P(02) 2011; ZRG1 CB-L(02) 2012; ZRG1; IMM-F(02) 2016
- AHA, Full Member, Basic Cell, Cell Structure and Survival Peer Review 1 Study Group, 2010-15
Recent Awards to Students at Dr. Cambronero's Lab:
Madhu Mahankali
- American Society of Cell Biology Travel Award, Philadelphia, PA
- Biomedical Sciences Ph.D. program's Graduate Student Excellence Award
- Best oral scientific presentation at the Biomedical Science Retreat
- American Society of Cell Biology Travel Award, San Francisco, CA
Amy Price
- Best Poster Presentation (Science Apprenticeship Program)
- The Mead Westvaco College Tuition Award
Isabel Campos
- Best Poster presentation (STREAMS Program, School of Medicine)
- Travel Award, Experimental Biology Meeting, Washington, D.C.
Mauricio Di Fulvio
- Travel Award, 36th National Meeting of the Society for Leukocyte Biology, Philadelphia, PA
- Best oral presentation at the 10th Annual WSU Molecular Biology Retreat
Kevin Daughtery
- Award for Best Poster Presentation (WSU-BSOM, Student Day)
Jeff Horn
- Graduate Student Excellence Award
Samuel Kantonen
- National Conference on Undergraduate Research (NCUR) Travel Award to Ithaca College, New York
Ramya Ganesan
- FETSKO Scholarship from the University Center for International Education
Nathaniel Hatton
- Undergraduate Honors Program fellowship
TOTAL PUBLICATIONS IN PEER-REVIEWED JOURNALS: 110; CITATIONS >3,000 (i10-index=69)
Representative of Doctorate Period:
Gomez-Cambronero, J., Mato, J.M., Vivanco, F. and Sanchez-Crespo, M. (1987) Phosphorylation of partially purified 1-0-alkyl-2-lyso-glycero-3-phosphocholine: acetyl-CoA acetyltransferase from rat spleen. Biochem. J.245, 893-898. PDF
Representative of Postdoctoral Period:
Gomez-Cambronero, J., Huang, C-K., Gomez-Cambronero, T.M., Waterman, W.H., Becker, E.L. and Sha'afi, R.I. (1992) Granulocyte-macrophage colony-stimulating factor-induced protein tyrosine phosphorylation of MAP Kinase in human neutrophils. Proc. Natl. Acad. Sci.USA. 89, 7551-7555. PDF
As Principal Investigator:
Johnson, G.M. and Gomez-Cambronero, J. (1995) Priming of tyrosine phosphorylation in GM-CSF-stimulated adherent neutrophils. J. Leukocyte Biol. 57, 692-698. Abstract
Gomez-Cambronero, J. (1995) Immunoprecipitation of a phospholipase D activity with anti-phosphotyrosine antibodies. J. Interferon Cytok. Res. 15, 877-885. Abstract
Joseph, D., Paul, C.C., Baumann, M.A. and Gomez-Cambronero, J. (1996) S6 kinase p90rsk in GM-CSF-stimulated proliferative & mature hemopoietic cells. J. Biol. Chem. 271, 13088-93. PDF
Gomez-Cambronero, J. and Veatch, C. (1996) Emerging paradigms in granulocyte macrophage colony-stimulating factor signaling. Life Sci. 59, 2099-2111. Abstract
Gomez-Cambronero, J. and Keire, P. (1998) Phospholipase D: a novel major player in signal transduction. Cell Signal. 10, 387-397.
Hayes, T.S., Billington, C.J., Robinson, K.A., Sampt, E.R., Fernandez, G.A. and Gomez Cambronero, J. (1999) Binding of granulocyte-macrophage colony-stimulating factor to adherent neutrophils activates Phospholipase D. Cell Signal. 11, 195-204.
Gomez-Cambronero, J. (1999) MAP kinase is activated in EGF-stimulated interphase but not in mitotic HeLa cells. FEBS Lett. 443, 126-130. PDF
Grishin, A., Sinha, S., Roginskaya, V., Boyer, M.J., Gomez-Cambronero, J., Zuo, S., Kurosaki, T., Romero, G. and Corey S.J. (2000) Involvement of Shc and Cbl-PI 3 kinase in Lyn-dependent proliferative signaling pathways for G-CSF. Oncogene 19, 97 105. Abstract
Andrews, B., Bond, K., Lehman, J.A., Horn, J.M., Dugan, A. and Gomez-Cambronero, J. (2000) Direct inhibition of in vitro PLD activity by 4-(2-aminoethyl) benzenesulfonyl fluoride. Biochem. Biophys. Res. Com. 273, 302-311.
Paul, C.C., Aly, E., Lehman, J.A., Page, S.M., Gomez-Cambronero, J., Ackerman, S.J. and Baumann, M.A. (2000) Human cell line that differentiates to all myeloid lineages and expresses neutrophil secondary granule genes. Exp. Hematol. 28, 1373-1380.
Lehman, J.A., Paul, C.C., Baumann, M.A. and Gomez-Cambronero, J. (2001) MAP kinase upregulation after hematopoietic differentiation: role of chemotaxis. Am. J. Physiol. Cell Physiol. 280, 183-191. PDF
Horn, J.M., Lehman, J.A., Alter, G., Horwitz, J. and Gomez-Cambronero, J. (2001) Presence of a phospholipase D (PLD) distinct from PLD1 or PLD2 in human neutrophils: immuno-biochemical characterization and initial purification. Biochim. Biophys. Acta 1530, 97-110.
Blum, J.J., Lehman, J.A., Horn, J.M. and Gomez-Cambronero, J. (2001) Phospholipase D (PLD) is present in L. donovaniand its activity increases in response to acute osmotic stress. J. Eukaryotic Microbiol. 48, 102-110.Abstract
Sampt, E.R., Fernandez, G.A., Lehman, J.A., Corey, S.J., Huang, C.-K. and Gomez Cambronero, J. (2001) A systematic approach to the complete study of a signaling molecule: ribosomal p90rsk as an example. J. Biochem. Biophys. Meth. 48, 219-237.
Gomez-Cambronero, J. (2001) The oxygen dissociation curve of hemoglobin: bridging the gap between Biochemistry and Physiology. J. Chem. Ed. 78, 757-759. Abstract
Baumann, M.A., Paul, C.C., Lemley-Gillespie, S., Oyster, M. and Gomez-Cambronero, J. (2001) Modulation of MEK activity during G-CSF signaling alters proliferative vs.differentaitive balancing. Am. J. Hematol. 68, 99-105.Abstract
Lehman, J.A. and Gomez-Cambronero, J. (2002) Molecular crosstalk between p70S6K and MAPK cell signaling pathways. Biochem. Biophys. Res. Com. 293, 463-469.
Gomez-Cambronero, J., Horwitz, J. and Sha'afi, R.I. (2003) Measurements of Phospholipases A2, C and D (PLA2, PLC and PLD): in vitro microassays, analysis of enzyme isoforms and intact cells assays. Methods Mol. Biol. 218, 155-1576. Abstract
Lehman, J.A., Calvo, V. and Gomez-Cambronero, J. (2003) Mechanism of ribosomal p70S6 kinase activation by GM-CSF in neutrophils: Cooperation of a MEK-related, T421/S424-kinase and a rapamycin-sensitive, mTOR-related, T389-kinase. J. Biol. Chem. 278, 28130-28138. PDF
Gomez-Cambronero, J. (2003) Rapamycin inhibits GM-CSF-induced neutrophil migration. FEBS Let. 550, 94-100.
Gomez-Cambronero, J., Horn, J., Paul, C.C. and Baumann, M.A. (2003) GM-CSF is a chemoattractant cytokine for neutrophils: Involvement of the ribosomal p70S6K signaling pathway. J. Immunol. 171, 6846-6855.Abstract
Gomez-Cambronero, J., Frye, T. and Baumann, M.A. (2004) Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPD. Leukemia Res. 28, 755-62.
Baumann M, Frye T, Naqvi T and Gomez-Cambronero J. (2005) Normal neutrophil maturation is associated with selective loss of MAP kinase activation by G-CSF. Leukemia Res. 29, 73-8.
Di Fulvio, M. and Gomez-Cambronero, J. (2005) Phospholipase D gene expression in human neutrophils and HL-60 differentiation. J. Leukocyte Biol. 77, 999-1007. Abstract
Horn, J., Miller, M. Lopez, I. and Gomez-Cambronero, J. (2005) The uncovering of a novel regulatory mechanism for PLD2: Formation of a ternary complex with Protein Tyrosine Phosphatase PTP1b and Growth Factor Receptor-Bound Protein GRB2. Biochem. Biophys. Res. Com. 332, 58-67. Abstract
Di Fulvio, M., Lehman, N., Xiaohong Lin, X, Lopez, I. and Gomez-Cambronero, J. (2006) The elucidation of novel SH2 binding sites on PLD2. Oncogene 25, 3032-3040. Abstract.
Lehman N, Di Fulvio M, McCray N, Campos I, Tabatabaian F, Gomez-Cambronero J. (2006) Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2. Blood 108, 3564-72. Abstract.
Lehman N, Ledford B, Di Fulvio M, Frondorf K, McPhail LC, Gomez-Cambronero J. (2007) Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR. FASEB J 21, 1075-1087. Abstract.
Di Fulvio M, Frondorf K, Henkels KM, Lehman N, Gomez-Cambronero J. (2007) The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF. J Mol Biol. 367, 814-824. Abstract.
Gomez-Cambronero J, Di Fulvio M, Knapek K. (2007) Understanding phospholipase D (PLD) using leukocytes: PLD involvement in cell adhesion and chemotaxis. J Leukoc Biol. 82, 272- 281. Abstract.
Di Fulvio M, Henkels KM, Gomez-Cambronero J. (2007) Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesis. Biochem Biophys Res Commun. 357, 737-742. Abstract.
Fulvio MD, Frondorf K, Gomez-Cambronero J. (2008) Mutation of Y(179) on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner. Cell Signal. 20, 176-185. Abstract.
Lehman, N., Ledford, B., Di Fulvio, M., Frondorf, K., McPhail, L.C. and Gomez-Cambronero, J. (2007) Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70S6 Kinase independently of mTOR. FASEB J. 21, 1075-1087.
Di Fulvio, M., Frondorf, K., Henkels, K.M., Lehman, N. and Gomez-Cambronero, J. (2007) The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF. J. Mol. Biol. 367, 814-824.
Di Fulvio, M., Henkels, K. and Gomez-Cambronero, J. (2007) Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesis. Biochem. Biophys. Res. Commun. 357, 737-742.
Gomez-Cambronero, J. Di Fulvio, M. and Knapek, K. (2007) Understanding Phospholipase D (PLD) using leukocytes: PLD involvement in cell chemotaxis and adhesion. J. Leukocyte Biol. 82, 272-281.
Di Fulvio, M., Frondorf, K. and Gomez-Cambronero, J. (2008) Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3Kand Akt-dependent manner. Cell Signaling 20, 176-185. Information from this paper has been curated into PhosphoSite.
Haines, E., Minoo, P., Feng, Z., Resalatpanah, N., Nie, X.M., Campiglio, M., Alvarez, L., Cocolakis, E., Ridha, M., Di Fulvio, M., Gomez-Cambronero, J., Lebrun, J.J. and Ali, S. (2009) Tyrosine Phosphorylation of Grb2: Role in Prolactin/Epidermal Growth Factor Crosstalk in Mammary Epithelial Cell Growth and Differentiation. Mol. Cell. Biol. 29, 2505-2520.
Henkels, K.M., Short S., Peng, H.-J., Di Fulvio, M. and Gomez-Cambronero, J. (2009) PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation. Biochem. Biophys. Res. Commun. 389, 224-228.
Henkels, K.M., Peng, H.-J., Frondorf, K. and Gomez-Cambronero, J. (2010) A comprehensive model that explains the regulation of Phospholipase D2 (PLD2) activity by phosphorylation-dephosphorylation. Mol. Cell Biol. 30, 2251-2263.
Knapek K, Frondorf K, Post J, Short S, Cox D, Gomez-Cambronero J. (2010) The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts. Mol. Cell. Biol. 30, 4492-506.
Gomez-Cambronero J. (2010) New concepts in phospholipase D signaling in inflammation and cancer. ScientificWorldJournal. 10, 1356-69
Tabatabaian F, Dougherty K, Di Fulvio M, Gomez-Cambronero J. (2010) Mammalian target of rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function. J. Biol. Chem. 285, 18991-9001.
Frondorf K, Henkels KM, Frohman MA, Gomez-Cambronero J. (2010) Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling. J. Biol. Chem. 285, 15837-47.
Henkels KM, Frondorf K, Gonzalez-Mejia ME, Doseff AL, Gomez-Cambronero J. (2011) IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3). FEBS Lett. 585, 159-66.
Peng H-J, Henkels KM, Mahankali M, Dinauer MC and Gomez-Cambronero J. (2011) Evidence for two CRIB domains in Phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2. J. Biol. Chem. 286, 16308-20.
Henkels KM, Farkaly T, Mahankali M, Segall JE and Gomez-Cambronero J. (2011) Cell Invasion of highly metastatic MTLn3 cancer cells is dependent on Phospholipase D2 (PLD2) and Janus Kinase 3 (JAK3). J. Mol. Biol. 408, 850-62.
Mahankali M, Peng H-J, Cox D and Gomez-Cambronero J. (2011) The mechanism of cell membrane ruffling relies on a Phospholipase D2 (PLD2), Grb2 and Rac2 association. Cell Signal. 23, 1291-8.
Peng J-H, Henkels KM, Mahankali M, Marchal C, Bubulya P, Dinauer MC and Gomez-Cambronero J. (2011) The dual effect of Rac2 on PLD2 regulation that explains both the onset and termination of chemotaxis. Mol. Cell. Biol. 31, 2227-40.
Gomez-Cambronero J. (2011) The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, Wasp and Rac2 (and a surprise discovery: PLD2 is a GEF). Cell Signal. 23, 1885-95.
Kantonen S, Mahankali M, Hatton N, Henkels, K, Park H, Cox, D and Gomez-Cambronero J. (2011) A novel PLD2-Grb2-WASp protein heterotrimer regulates leukocyte phagocytosis in a two-step mechanism. Mol. Cell. Biol. 31, 4524-37.
Mahankali M, Peng H-J, Henkels KM, Dinauer MC and Gomez-Cambronero J. (2011) Phospholipase D is a GTP exchange factor (GEF) for the GTPase Rac. Proc Natl Acad Sci U S A. 108, 19617-22.
Gomez-Cambronero J and Henkels K (2012) Phospholipase D (PLD). In Encyclopedia of Signaling Molecules. Ed. by S. Choi, Springer Science LLC, New York, Chapter 17, pp. 1409-19.
Gomez-Cambronero J and Henkels K (2012) Cloning of PLD2 from baculovirus for studies in inflammatory responses. Methods Mol. Biol. 861, 201-25.
Gomez-Cambronero J, Allen L-A H, Cathcart MK, Justment L, Kovacs EJ, McLeish KR and Nauseef WM (2012) How to Write Your First Grant Proposal. Nature Immunology. 13, 105-8.
Di Fulvio, Frondorf K, Henkels, K, Grunwald Jr WC, Cool D and Gomez-Cambronero J (2012) Phospholipase D2 (PLD2) shortens the time required for myeolid leukemic cell differentiation: Mechanism of action. J. Biol. Chem. 287, 393-407.
Gomez-Cambronero J. (2012) Structure analysis between the SWAP-70 RHO-GEF and the newly described PLD2-GEF Small GTPases 3, 202-8.
Gomez-Cambronero J. (2012) Biochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2). J Leukoc. Biol. 92, 461-7.
Mahankali M, Henkels KM, Alter G, Gomez-Cambronero J. (2012) Identification of the Catalytic Site of Phospholipase D2 (PLD2) Newly Described GEF Activity. J Biol. Chem. 287, 41417-31.
Henkels KM, Mahankali M, Gomez-Cambronero J (2013) Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras. Cell Signal. 25, 198-205.
Ye Q, Kantonen S, Gomez-Cambronero J. (2013) Serum Deprivation Confers the MDA-MB-231 Breast Cancer Line with an EGFR/JAK3/PLD2 System That Maximizes Cancer Cell Invasion. J Mol Biol. 425, 755-66.
Mahankali M, Henkels KM and Gomez-Cambronero J (2013) A GEF-to-phospholipase molecular switch caused by phosphatidic acid that explains leukocyte cell migration. J. Cell Science 15,1416-28.
Ye Q, Kantonen S, Henkels, K. and Gomez-Cambronero J. (2013) A new signaling pathway (Jak-Fes-Pld) that is enhanced in abnormal proliferation of breast cancer cells. J Biol Chem 288,9881-91.
Speranza F, Mahankali M and Gomez-Cambronero J. (2013) Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over β-catenin-induced PLD expression. J Leukocyte Biol 94, 953-962.
Na RH, Zhu GH, Luo JX, Meng XJ, Cui L, Peng HJ, Chen XG, Gomez-Cambronero J. (2013) Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells. BMC Microbiol 13:125.
Henkels KM, Boivin GP, Dudley ES, Berberich SJ and Gomez-Cambronero J. (2013) Phospholipase D (PLD) drives cell invasion, growth and metastasis in a human breast cancer xenograph model Oncogene, 32, 5551-5562.
Gomez-Cambronero J. (2014) Phosphatidic acid, phospholipase D and tumorigenesis. Adv Biol Regul. 54:197-206.
Usatyuk PV, Fu P, Mohan V, Epshtein Y, Jacobson JR, Gomez-Cambronero J, Wary KK, Bindokas V, Dudek SM, Salgia R, Garcia JG, Natarajan V. (2014) Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells. J Biol Chem. 289, 13476-91.
Gomez-Cambronero J, Carman GM. (2014) Thematic Minireview Series on Phospholipase D and Cancer. J Biol Chem. 289, 22554-22556.
Gomez-Cambronero J. (2014) Phospholipase D in Cell Signaling: From a Myriad of Cell Functions to Cancer Growth and Metastasis. J Biol Chem. 289, 22557-22566.
Gomez-Cambronero J, Kantonen S. (2014) A river runs through it: how autophagy, senescence, and phagocytosis could be linked to phospholipase D by Wnt signaling. J Leukoc Biol. pii: jlb.2VMR0214-120.
Speranza F, Mahankali M, Henkels KM, Gomez-Cambronero J. (2014) The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D. J Biol Chem. 2014 Sep 2. pii: jbc.M114.597146.


text:
As mobile evolves into a composite of voice, text, video, Internet, games, apps and audio, Nielsen's measurement services help you analyze and respond to the consumer who is always connected.
Nielsen metrics for mobile devices (including "connected" devices like iPads, Kindles and tablets) are already the market standard for market share, consumer satisfaction, device share, service quality, revenue share, advertising effectiveness, audience reach and other key indicators in the mobile marketplace.
Our monitoring of the rapid expansion of technology and adoption enables our clients to stay ahead of the steep curve. Nielsen benchmarks mobile advertising investment to other media platforms, and help clients maximize their marketing exposure. In addition, we uncover demographic and behavioral targets to predict which consumer segments and which tactics offer the highest potential for success.
Nielsen uses a broad range of measurement tools to help companies make the most of their investments in mobile, including:
No other company can match Nielsen's depth and breadth when it comes to analyzing the mobile market. We were among the first to recognize the marketing potential of mobile devices and we pioneered and invested in methodologies to measure consumer response to mobile advertising. As a result, we have the most comprehensive view of mobile devices and platforms and the deepest understanding of the ways consumers engage with them. We even hold patents for on-phone meters that allow detailed tracking of a participating panel of mobile subscribers.
Learn more about mobile measurement by contacting us.


text:
I know we've done quite a few discussions about the various atheist-freethought themed songs and music that we all like; I thought I'd "flip the switch" and ask the alternative question.
Are there any christian or religious bands, or songs, that you happen to like? Bands like P.O.D., Skillet, and EARLY Evanescence come to mind - and for you old schoolers like me, how about Stryper? ;)
Right now I have to admit that there is ONE song by Skillet that I actually like - a lot. Not enough to go to a xian lovefest concert of theirs, but this song is actually pretty good. It is called "Awake and Alive", and I have to admit I dig it. A lot.
Does anyone else enjoy (even if you're in the closet about it) some songs/groups that are decidedly xian?
Views: 1097
Jack White nearly became a priest instead of going into the music business, and he's one of my favorite artists right now. But not a lot of his material is actually religious.
I still like some Amy Grant. I'm a rebel.
I like "My Sweet Lord" by George Harrison and that "Hallelujah" that plays in Shrek. The bands are not religious, but you could say the songs are. I don't see why I wouldn't like the songs, I mean, I don't care what the guy who wrote it believed. I just like the songs because they are beautiful.
Hallelujah is by Leonard Cohen, and it is about sex. :p
I recently sold all of my old Christian CD's to a used movie/music/bookstore. I never listened to any of them anymore and I couldn't stand them being around reminding me of how closed-minded and dumb I once was... I used to be really into contemporary Christian music and praise and worship songs. I still like Skillet a lot and Plumb has a few good songs too.
My 3 favorite composers are Beethoven, JS Bach, and Mozart (who is by far my favorite). I sang in a LOT of choruses when I was younger, and I have to admit I loved singing many choral songs. The Lacrimosa movement of Mozart's Requiem is my fav piece of all time.
Anyway, one of the songs we sang in HS chorus had a line in it that I still love to this day:
JS Bach. He is cool. He wrote Jazz for Sunday School.
(for those not into music history, Bach is credited with inventing the unusual timings, syncopation, and feel of what we call Jazz today)
Anything by Anberlin. They are not really a Christian band, rather a band made of Christians, but they do have a few songs that have a religious tone to them, but I still like them.
And then there is Matisyahu, who is one of my favorite artists.
And I also like heavier bands like The Devil Wears Prada and UNDERØATH
Then there's lesser known bands like EleventySeven and TwentyFour64.
same here
Starflyer 59 I still listen to.
You can hardly understand anything he says (partly that's me just not hearing lyrics but music) and most of the songs are just about life, and IMO it's great music.
Stuff that I listened to after breaking out of Christianity but rarely listen to now:
Jars of Clay Every once in a while for nostalgia, some of their stuff not even bothering to tag a Christian line.
Plum (same as above)
Five Iron Frenzy ( for lols and memories of shows I'd been to)
Viva Voce
The only reason I mentioned Evanescence is that they got their start as a xian band, and started on that xian label (can't remember the name right now). Their first mainstream hit, "Bring Me to Life", has the lead singer of 12 Stone - a xian rock band - singing the duet with Amy Lee.
I forgot about Flyleaf - they're definitely on my "some of their stuff I like" list, too.
Would anyone count U2 as a xian band? They have quite a few blatantly religious songs...
I would count U2 as a religious band, I don't care for them at all their very vanilla. Evanescence kills me, It's like one of those noises only dogs can hear, but I can hear it and it makes me want to dig my ears out with a spoon. Good topic man.
I love the credence clearwater revival. I don't know if that counts, but their always singing about jesus this and lordi that, but their really good anyway.


text:
The US dollar rose against most major currencies on Friday and hit a two-month high against the euro.
Traders are worried about the US "fiscal cliff," a series of tax increases and government spending cuts set to kick in at the beginning of next year.
Renewed fears about Europe's debt crisis are also pushing the dollar higher. European Central Bank President Mario Draghi warned this week that Europe's economy remains weak.
The euro fell to $1.2713 late Friday from $1.2750 late on Thursday. The euro fell as low as $1.2688 earlier, its lowest point against the dollar since September 7.
The British pound fell to $1.5903 from $1.5981.
The dollar rose to 79.45 Japanese yen from 79.38 Japanese yen, to 0.9487 Swiss franc from 0.9457 Swiss franc and to 1.0004 Canadian dollar from 99.98 Canadian cents.


text:
Listen to millions of songs of up-and-coming artists. Add your favorites to your own playlists, interact with bands, download or purchase songs.
Great bands deserve great sound? We couldn't aggree more. Our streaming sound quality is 160kbps, higher than comparable other sites. Meaning? Better sound for your ears. And we offer lossless downloads for perfect aural pleasure.
Favorite bands? Guilty pleasure music? Get your own profile page to connect with artists or other listeners. Share as little or as much as you like.
You like to support independent artists? With every store purchase we offer the option to tip. It's so much appreciated!
Our service is completely free. You pay nada, zilch, nothing. And you still have access to our complete music catalog. Sweet!
Beautifully designed band/artist pages let you showcase your music in the best possible way. Focus is on your music, for sure. But let users see more of you with an interview, videos, and photos.
We give you unlimited song uploads. Your listeners will appreciate our 160kbps song streams (and your choice of 320kbps or lossless format for downloads).
Let's talk business: you can sell your music in our store. There are no fees for this service, we take only a competetive cut of the sales price.
More ways for you to make money? We've been known as the place to license your music for years. License to other artists, labels, TV shows, movies. We currently don't handle license fulfillment ourselves but we're looking into adding this soon.
All our basic services are free to use. We do offer an optional premium service too though: you can design your page any way you like with CSS styles. All downloads are 320kbps or lossless. And there is no advertising on your page or player.


text:
- Eat & Drink
- News & Features
- Travel
- Culture
- Style
- Home
- City Life
- Scene
- Videos
- Search
- Events
- Cityguide
- The List
- Guide to Private Schools
- Weddings
- Charity Datebook
- Interiors California
- Daily Newsletters
- Best of Wine Country
- Timepiece & Jewelry Book
Our Publications
- Aspen
- Atlanta
- Boston
- Chicago
- Dallas
- The Hamptons
- Hawai'i
- Houston
- Las Vegas
- Los Angeles
- Miami
- New York
- Orange County
- Palm Beach
- Philadelphia
- San Diego
- San Francisco
- Scottsdale
- Silicon Valley
- Washington, D.C.
LARÔDES Fashion House VIP reception
On March 30th, LARÔDES Fashion House hosted VIP pre-launch reception in a private mansion in San Francisco.
LARÔDES was created for all dreamers and believers that quality and exceptional craftsmanship is the way of life. It is a bon-vivant life, a life well-lived. LARÔDES designer's passion for the finest materials and tailoring led him to scout and discover the best manufacturers in Italy in order to turn our dreams into a reality.
Guests enjoyed the atmosphere flavoured by Italian movies and music, Jun Yang art performance and a delicious amuse bouche.
Conceptualized by Smart Affinity Group, and realized with a help of Ginger Elizabeth Chocolates, Which Winery, Luna Winery, Bluxome Street Winery, Colleta Gelato.
Photography: Eli G Studio


text:
When it comes to looking chic this spring, floral prints are the way to go. Pop Sugar reports the trend is set to continue into fall of next year as well – many of the top designers at the current New York City Fall Fashion 2013 shows recently debuted looks with floral patterns.
From Valentino to Chanel and even Vera Wang, flowered patterns are a major statement for the entire year. Some of the best ways to wear flowers in your ensembles is by looking for a few stand out pieces with brightly printed patterns. For example, rocking an adorable flower patterned sun dress with a simple jean jacket is sure to garner plenty of attention.
On the same note, you can also make flowers more formal for fall. Marie Claire magazine reports designer Prabal Gurung' floral prints showed off this trend perfectly in his recent collection. Models at his NYC show stunned in peplum style tops with red floral prints on the bottom half of the shirts.
Since flowers seem to be in fashion, why not spruce up your home with a gorgeous bouquet? Prepare for spring by ordering a collection of flowers like Teleflora's How Sweet It Is bouquet. The mix of orange roses and hot pink miniature carnations is sure help you beat the wintertime blues.
This article is brought to you by Teleflora on Google+


text:
At this point, the media storm about Health and Human Services story is growing and becoming more complex. Once again, the goal here at GetReligion is to focus on the mainstream news coverage of the emerging story lines.
At the moment, the main framing device in the news and commentary in the mainstream press remains the same. It looks something like this:
(1) The White House says this is a story about birth control and women's health. Thus, this is a story about birth-control debates between a small number of traditional Catholics and the rest of the nation, including most Catholics.
(2) The nasty Catholic bishops and GOP candidates are attempting to frame this story as a battle over the First Amendment and religious liberty -- but that's just politics, not doctrine. In other words, that's mere right-wing political spin.
(3) Thus, the vast majority of news reports are framing this as a birth-control battle, perhaps with a few conservative voices thrown into the mix. Many journalists, it seems, have decided that even mentioning "religious liberty" and related Constitutional issues is forbidden, since that would raise the issue of whether religious traditionalists in all faiths have a valid point worthy of fair and accurate coverage. The "religious liberty" nuts are sort of the flat-earth people in this scenario.
The problem is, lots and lots of people -- liberal Catholics and most Protestants -- who are not opposed to common forms of birth control are very upset about these HHS rules. Check out this blockbuster, cover-our-tails piece from Bloomberg.
Then, after reading that, move on to this, which includes some of the most pointed language that I have seen on the Catholic left, care of Michael Sean Winters at The National Catholic Reporter:
Yes, I want a solution to this mess. But, I also want a victory by which I mean I want a really robust conscience exemption. I want any change by the White House not only to work in terms of resolving this issue but to send a clear and unambiguous statement that in this great diverse, pluralistic country of ours, there is room for us Catholics to be Catholic, with all of our quirks, and that the government recognizes that they have no business telling religious organizations what their mission is or how to manage it. I do not want the White House to cry "uncle" for the sake of crying uncle. But, when somebody punches me in the nose, and when someone punches my friends Sr. Carol Keehan and Father John Jenkins and countless others in the nose, I am not going to rush to make nice with them either. There needs to be an apology. And the President needs to go to the pro-choice caucus and explain that their stance imperils the entire Affordable Care Act, both politically and legally, and without that, they would not be discussing extending contraception to anyone.
Make no mistake about it - those who support denying Catholic institutions a more robust exemption have placed their commitment to pro-choice orthodoxy above their commitment to health care reform. Is that progressive? Is that something progressive Catholics, who fought so hard to pass the ACA, want to defend? It is time for so-called progressive Catholics to stop serving as chaplains to the political status quo and recognize a first principle when they see one. It is time for Catholics to insist that a conscience exemption that only applies to religion on Sunday and no help for the poor unless they are also Catholic is no conscience exemption at all.
Of course, it's easy to ask: Why do religious groups need a conscience clause when they have the First Amendment, when they have a history of church-state law that says the government does not have the power to get entangled in doctrinal issues of this kind? The state does not have the right to say that "religion" is when people sit in pews, but not when they feed the poor, teach children and heal the sick -- in institutions that are explicitly and meaningfully connected to religious traditions, laws and doctrines.
As I have said before, this is an argument about the separation of church and state, one rooted in the old liberalism that fiercely defended freedom of speech (and the press, by the way), freedom of association and freedom of religion.
So if Winters, Vice President Joe Biden, Chris Matthews, Cardinal Roger Mahony and flocks of other Catholic progressives -- if the old liberals, in other words -- see this as a religious liberty issue, what should one call the following point of view from a major journalist who all but dismisses the First Amendment claims?
This aggressive claiming of the moral high ground is close to drowning out the regulation's supporters, inside and outside of the Obama administration. Maybe I'm missing something, but I haven't seen a comparably full-throated defense of the regulation, issued last month by the Department of Health and Human Services, except on pure policy grounds. (And there are indications this week that even some in the administration, or at least in President Obama's campaign apparatus, may be getting cold feet.) While the policy grounds are fully persuasive -- the ability to prevent or space pregnancy being an essential part of women's health care, one that shouldn't be withheld simply because a woman's employer is church-affiliated -- the purpose of this column is to examine the conscience claim itself, directly, to see whether it holds up.
An obvious starting point is with the 98 percent of sexually active Catholic women who, just like other American women, have exercised their own consciences and availed themselves of birth control at some point during their reproductive lives. So it's important to be clear that the conscientious objection to the regulation comes from an institution rather than from those whose consciences it purports to represent. (Catholic women actually have a higher rate of abortion than other American women, but I'll stick to birth control for now.) While most Catholics dissent in the privacy of their bedrooms from the church's position, some are pushing back in public. The organization Catholics for Choice, whose magazine is pointedly entitled Conscience, is calling on its supporters to "tell our local media that the bishops are out of touch with the lived reality of the Catholic people" and "do not speak for us on this decision."
That, of course, is the voice of Linda Greenhouse of The New York Times -- perhaps the most influential reporter who has ever covered the U.S. Supreme Court.
Is this, perhaps, the voice of the establishment media in the prestigious offices on high? Is this the voice charged with deciding who is a good Catholic and who is a bad Catholic, in the eyes of the government and, almost as important, the Times?
Greenhouse has, of course, spoken out these kinds of cultural, legal and religious issues before. Remember her famous sermon at Radcliffe about the values of the '60s, which caused heat at NPR and then at the Times? The one that said:
... (We) were absolutely united in one conviction: the belief that in future decades, if the world lasted that long, when our turn came to run the country, we wouldn't make the same mistakes. Our generation would do a better job. I cried that night in the Simon and Garfunkel concert out of the realization that my faith had been misplaced. We were not doing a better job. We had not learned from the old mistakes. Our generation had not proved to be the solution. We were the problem.
And of course my little crying jag occurred before we knew the worst of it, before it was clear the extent to which our government had turned its energy and attention away from upholding the rule of law and toward creating law-free zones at Guantanamo Bay, Abu Ghraib, Haditha, and other places around the world. And let's not forget the sustained assault on women's reproductive freedom and the hijacking of public policy by religious fundamentalism.
My point, again, is not who is wrong and who is right in this journalism puzzle.
Thus, my point is not that the "religious liberty" camp should be covered and the "birth control" arguments ignored. In fact, I will say this again: There is no way to cover this story without hitting the birth-control angle and hitting it hard. There is no way to cover this story without covering its political angles.
From a journalistic perspective, this is not doctrine vs. politics. It's both-and. This is not "religious liberty" vs. the sexual revolution. It's both-and. The journalistic framing in this story must take seriously the line (currently) coming out of the White House and the voices of observant Catholics, Eastern Orthodox Christians, Orthodox Jews, evangelical Protestants and others who believe that the U.S. government is trying to punish those who refuse to edit centuries of tradition and law in order to conform to Caesar. (By the way, have any church groups officially spoken out to back the White House on this?)
Now, let's use the comments pages to share the URLs for hard-news stories and other commentaries that attempt this "both-and" approach to framing this story -- an old school, journalistic, old-liberalism approach. You can start right here, with this new essay by the progressive Catholic scribe David Gibson, writing for Religion News Service.


text:
See a video of this project here.
Inspired by Table Wear from designers Barbara Jacobson and Mary Groves of Me and My Sister Designs
Quilt tester: Mary Pepper
11-2-1/2x42" precut strips assorted blue batiks (table runner center)
1-2-1/2x42" precut strip light blue batik (table runner center)
1/8 yard red-orange print (piping)
1-1/2 yards dark blue print (border, backing)
1-1/2 yards fusible fleece (such as Pellon 987F)
Finished table runner: 16x50"
Quantities are for precut 2-1/2x42" strips and 44/45"-wide, 100% cotton fabrics.
Measurements include 1/4" seam allowances. Sew with right sides together unless otherwise stated.


text:
Product Review: Leupold VX-R Patrol
Most law enforcement optics don't really stand out — the Leupold VX-R Patrol does
I recently tested the Leupold VX-R Patrol riflescope, which was designed for fast target acquisition and enough flexibility to give the officer a scope that will work for most patrol applications.
I get to test a lot of law enforcement optics. Most of them are high quality. They have to be, considering the abuse for which they are designed. Most of them don't really stand out. The Leupold VX-R Patrol does.
The VX-R Patrol is a 30mm main tube low magnification scope that uses Leupolds twin bias erector system and 1/4 MOA click adjustments for accuracy. This a pretty fine adjustment for a carbine, which often gets 1/2 MOA adjustments.
Two Versions
The VX-R Patrol comes in two versions, a 1.25-4x20 FireDot Special Purpose Reticle and the 3-9x40 with a FireDot TMR (Tactical Milling Reticle). I picked the 1.25-4x20 SPR because the magnification and field of view is appropriate for a large percentage of patrol applications. For example, an officer could turn the power to its lowest setting and use it during a close-quarters entry. Crank it up to 4x and the AR-15 VX-R combination allows some standoff distance between the officer and a barricaded subject.
The reticle is a crosshair with a center circle setup with mil ticks and thicker posts outside the center of the image. This kind of reticle allows for quick target acquisition because the image is simple while giving the shooter a reliable sighting standard at longer distances. I understand that this product can be ordered with the CM-R² reticle also, but I would pick the SPR here.
The most profound feature of the scope is the FireDot center illumination. This is an advanced fiber optic feature that puts a bright red dot in the center of the crosshairs. It worked in daylight and twilight. There wasn't any bleed over on the image and the crispness of the reticle never wavered, even when making focusing or power adjustments.
This isn't as simple as it looks. Many other manufacturers have optics that use an illuminated aiming point. Cheaper ones are obviously inferior when one cranks up the power. There is usually a discernible halo or a distortion in the shape of the dot. The Leupold VX-R Patrol reticle had edge-to-edge usability on the reticle.
The FireDot uses a CR 2032 cell inside a protrusion that looks like a third turret on the left side. One presses the silent switch in the center to turn it on and adjust the illumination. After the initial adjustment, it goes into standby when the scope is still for a while. When it is moved, it returns to the user's setting. There is no lag time in the motion detection so if I didn't tell you, you wouldn't know, except it would seem that the scope got a lot of life from one cell.
I found that the image in this scope gave my vision an easy-to-acquire reference, allowing for quick identify-and-shoot shot strings and accurate deliberate sessions using the same setup. We used some known standards:
1.) A Holding and Kaufmann Ironworks (www.hkironworks.com) upper, with which I can crank out 1 hole groups all day long, followed by run-and-shoot double taps with zero failures. HKI is a manufacturer near my testing range. This is pretty convenient for me. I test a lot of uppers and this one outshoots most of the custom products out there.
2.) Winchester Ballistic Silvertip cartridges. I've just begun to use these polycarbonate tipped bullets and they work for me. This particular cartridge, though not necessarily a law enforcement cartridge (SBST223), runs at a pretty high velocity with low recoil.
3.) My friend Max Messina from Oakdale (Calif.) PD is a known standard because he shoots carbines much better than I do. I value his opinions on range equipment because when he helps test things, he really puts them to work.
4.) Leupold's new Integral Mounting System. This is a one piece, rail mount system that uses torx screws and beefy rings with 1/2 inch keeper nuts to set the scope. This takes most of the guesswork out of figuring out eye relief and leveling. I found I could mount the scope on the mount, then mount the assembly on the carbine. I was able to dismount this rig, re-mount it and shoot the same "sight in". It is such a solid set up, I would consider abandoning standard mounts and going with this on my currently mounted scopes. I would only add one thing: Torque limiting keeper nuts. You know... the kind that can't be over tightened.
Leupold uses blackened lens edges in this scope, which reduces spurious reflections in the tube. Their DiamondCoat coating also adds to the light transmission and abrasion resistance. Having subjected another test scope to some abuse to test the DiamondCoat feature, I can testify to its resistance to user errors like not blowing the dust off the lens before cleaning it in a dusty environment.
True Colors
I could tell you that the scope is bright and clear, but that is not really quantifiable. Using my optical test patterns, it rendered true colors, which looked isn't a surprise. My greatest treat was putting this scope on my optical test patterns and finding that it resolved horizontal and vertical grids edge to edge at a better level as most of the optics I had on hand. One other neat thing: This scope has a one-turn focus adjustment for the eyepiece. I have one of those complicated prescriptions on my glasses. I could quickly adjust this to work for me, glasses on or off.
How did it shoot? First, 1.25 magnification is close enough to 1.0 for a shooter to use occluded eye techniques, the same way one would use a non magnified optic. I found that I could crank it down and shoot with both eyes open. No part of the scope body got in the way, and the image was continuous. Maybe Leupold got some input from the 3 Gunners here. My only wish was that the reticle be placed in the first focal plane, which means that its size would remain consistent with the variable power.
The 4 Power setting gave the scope some reach, and its resolving ability allows it to outclass many other short tube products. I have a friend who serves as a deputy in a very rural area and he asked me if there is a product out there that could be used in the patrol car and as an interdiction tool for well armed, well emplaced growers in the high country. This is the product, especially with the new waterproofing/anti fog design. This scope allows for target and mission transition.
The VX-R Patrol in 1.25-4x20mm is the closest thing to a patrol scope that will do it all. Folks, this is an easy one to swear in for duty.
Request product info from top Police Sights and Scopes companies
Thank You!


text:
Is there a detailed description for a Hartmann mask based collimation process?
I've been told by a friend that is possible to collimate an SCT by placing a three round holes Hartmann mask at the secondary and then covering one hole at a time. Unfortunately the guy did not clearly describe the full procedure and what I should try to obtain looking in the eyepiece (or looking at an attached webcam video).


text:
MEMPHIS, Jan. 19 (UPI) -- Thieves wielding sledgehammers and guns stormed an upscale Memphis mall jewelry store Saturday night and made off with $700,000 in Rolex watches, police said.
Police said at least five men, possibly six, took part in the bold smash-and-grab robbery at 7:39 p.m. at Reed's Jewelers in Wolfchase Galleria, the (Memphis) Commercial Appeal reported.
The thieves, dressed in dark clothes, smashed display cases and stuffed 65 Rolexes valued at $11,000 apiece into pillow cases before fleeing through two exits.
Shoppers scattered during the incident but no one was injured in the robbery, the newspaper said.