text:
LG VX8350 Review
posted by PhoneArena Team / Sep 28, 2007, 3:30 AM
phone uses an internal antenna, or if it could be related to something else. The Call Quality through the earpiece was also not as clear and static free as on the VX8300. Several times we noticed the presence of static and interference during calls, which we were unable to duplicate on the VX8300. Lastly, the earpiece volume on the VX8350 was also not as loud as on the VX8300. One positive thing that we did like was that the Speakerphone on the VX8350 did not suffer from the large amount of distortion that is created when using the Speakerphone on the VX8300.
The Included 1000mAh battery is rated by LG to provide 3Hr 27Min of Talk Time or 8 Days of Standby Time on a full charge. During out testing, we were able to achieve up to 3Hr 30Min of Talk Time, yet were only able to get up to 5 Days of Standby Time. Despite this discrepancy, the amount of Talk and Standby Time provided by the battery is sufficient, considering that fact that most phones are now coming with smaller capacity batteries.
It is unfortunate when a new phone does not live up to the previous model that came before it, but this is the case with the VX8350, where the physical design changes are outweighed by negative aspects of the device. There are several key areas that concern us about the VX8350. The first being the poorly designed hinge that flexes whenever the smallest amount of force is placed upon it. This makes us feel that the hinge will not hold up over time with everyday use. The second area of concern is the Reception and Call Quality. We are usually impressed by how well LG phones can hold reception and by how good the earpiece quality is. It is too bad that this is not the case with the VX8350. We experienced several drop calls in areas where the VX8300, VX8550 Chocolate, and enV were able to maintain a signal, and the Call Quality through the earpiece was also not as good, with noticeable static and interference. Verizon is currently selling the VX8350 for $80 after Rebate, which we feel is overpriced for this device. If you are looking for a good quality phone for Verizon, we would recommend going with the VX8550 Chocolate or enV. Both cost more, but will last longer and provide overall better quality.
phone uses an internal antenna, or if it could be related to something else. The Call Quality through the earpiece was also not as clear and static free as on the VX8300. Several times we noticed the presence of static and interference during calls, which we were unable to duplicate on the VX8300. Lastly, the earpiece volume on the VX8350 was also not as loud as on the VX8300. One positive thing that we did like was that the Speakerphone on the VX8350 did not suffer from the large amount of distortion that is created when using the Speakerphone on the VX8300.
The Included 1000mAh battery is rated by LG to provide 3Hr 27Min of Talk Time or 8 Days of Standby Time on a full charge. During out testing, we were able to achieve up to 3Hr 30Min of Talk Time, yet were only able to get up to 5 Days of Standby Time. Despite this discrepancy, the amount of Talk and Standby Time provided by the battery is sufficient, considering that fact that most phones are now coming with smaller capacity batteries.
It is unfortunate when a new phone does not live up to the previous model that came before it, but this is the case with the VX8350, where the physical design changes are outweighed by negative aspects of the device. There are several key areas that concern us about the VX8350. The first being the poorly designed hinge that flexes whenever the smallest amount of force is placed upon it. This makes us feel that the hinge will not hold up over time with everyday use. The second area of concern is the Reception and Call Quality. We are usually impressed by how well LG phones can hold reception and by how good the earpiece quality is. It is too bad that this is not the case with the VX8350. We experienced several drop calls in areas where the VX8300, VX8550 Chocolate, and enV were able to maintain a signal, and the Call Quality through the earpiece was also not as good, with noticeable static and interference. Verizon is currently selling the VX8350 for $80 after Rebate, which we feel is overpriced for this device. If you are looking for a good quality phone for Verizon, we would recommend going with the VX8550 Chocolate or enV. Both cost more, but will last longer and provide overall better quality.
- Speakerphone Is Loud And Has Low Distortion
- Updated Styling
- Poorly Designed Hinge
- Low Reception In Fringe Areas
- Call Quality Not As Good As Other LG Phones
- Camera Is Useless
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33 Comments
1. lee unregistered
I went straight to the 8350 from an 8300, and I have to say I completely disagree with the review. Not only do I not experience the crackling or 'static' that the reviewer mentions, but the sound quality through the earpiece has actually been better and louder than the 8300's. Additionally, the speakerphone on the 8350 is much better than the 8300's- the 8300's would get very buzzy at anything above medium volume, while the 8350's stays clean even at high volume. The only area where the 8300 is better is battery life, really, and not by all that much. I'm happy with the 8350, and wouldn't go back to the 8300.
posted on Oct 20, 2010, 1:55 AM 0
15. Keith C. unregistered
Perhaps they made a mid model tune up due to some of the early complaints. The 8350 I bought last week sounds much better than the 8300. The ear piece sounds cleaner....there is none of that buzz at the higher volume levels that plagued the 8300. My version is loud and clear. People on the other end like the way I sound. They like the way I sound more than the Motorola W385, W755, Q9m, Blackberry 8330, 8130 Pearl, Palm Centro (that was a toss up), LG enV2 and Samsung U550. These conclusions were reached while I was talking from the verizon store to a friend on a nextel network and a lot of these comments involve simple preference. There is no argument against preference. I am not saying the other phones sounded bad (although a couple of them actually did) I am saying she liked the way mine sounded better. She has a very nice phone by the way. Best I have ever heard. So anyway my experience is quite contrary to the reviewers which leads me to suspect that my 8350 might be second generation....any way to open it up and tell? The inside does say hardware revision 1.1 What does that mean? As to the RF sensitivity issue, we live in a deep fringe area ..right on the edge. So much on the edge that if you even touch the antenna on some of our other phones the call is dropped. In the Verizon network the only phone that we have owned that has reliably worked out there is the Motorola E-815. It could just squeeze by. This particular sample of 8350 is very good in the area of RF sensitivity. It is not outstanding...not even great. But it is pretty good. Just my two cents.
posted on Jul 05, 2008, 9:10 PM 0
31. bcaster1
Posts: 1; Member since: Jan 04, 2010
I also completely disagree with the review. This can be considered a long term review of the VX8350. I have owned the phone for 20 months now, and I have to say, it has performed flawlessly. All the issues people seem to have with the supposedly faulty hinge never happened to me. The phone has been dropped numerous times over the last 2 years and has always worked without issue. The charging port (I too lost the little dust cover) has never presented any problems and works with both my AC charger at home and my car charger on the road. Battery life has been better than advertised, I usually get about 7-8 days of standby and 4-5 hours of talk even now with 20 months on the battery. Oh, and for all the whiners that complain it is too hard to open, here's a handy guide: Step 1: Hold the phone in your right hand. Step 2: Use your right middle or ring finger to flip open the phone. Step 3: Quit complaining about about things just to fit in with the pack and go take a dexterity class.Basic hand eye coordination folks, it's not that difficult. Voice quality has been great, and this phone does NOT drop calls like some others have mentioned. Most of the time I have 1 or 2 bars near where I live, but even with 1 bar the call completes without drops. Music quality is ok, but about what you would expect from 2 tiny phone speakers. Speaker volume is great, especially when using VZ Navigator. The only complaint I do have is the inability to lock the side buttons. When wearing it on my belt, I have noticed several occasions where the camera will start itself up and take pictures of darkness while still in the holster due to the buttons being pushed inadvertently. This being the only complaint, however, I can live with it. The pros definately outweigh the cons. I know no one is buying this phone anymore but I just wanted to set the record straight. Great phone at a great price.
posted on Jan 04, 2010, 10:06 AM 0
32. partsman_ba unregistered
Wow. "Supposedly" faulty hinge? Just wait, yours will break soon. I've had 3 of these phones - my original that I bought new and two that I picked up on eBay so I wouldn't have to pay $9.99 for data I won't use. All of them now have a broken right hinge. It's because that's where the spring is for snapping it open and shut, and they didn't put enough plastic around it. Doesn't affect the (awesome) operation of the phone other than having to be careful opening and closing the clamshell. Have a look at the 8360's hinge area and you'll see that they really beefed it up in response to the problem.
posted on Sep 02, 2010, 2:33 PM 0
2. unregistered
Try and re-read the review. "Lastly, the earpiece volume on the VX8350 was also not as loud as on the VX8300. One positive thing that we did like was that the Speakerphone on the VX8350 did not suffer from the large amount of distortion that is created when using the Speakerphone on the VX8300."
posted on Sep 28, 2007, 10:26 PM 0
3. Jon unregistered
The thing that stood out most were the comments regarding the hinge. The hinge design is IMPROVED. It flexes because there is a soft pad that allows for give so the hinge doesn't break. Open the phone, lay it face down on a table, and pound down on it. It gives! No breaking, no damage! I find the speaker quality and speakerphone to be far better and have not experienced any "tin can" sounding music. I find the screen to be far clearer than the original and pictures show much more detail. Really, I have no idea what phone you're talking about!!
posted on Sep 29, 2007, 9:15 AM 0
4. Mr. V unregistered
I have to concur with the poster above- the reviewer definitely missed the fact that the the stop for the flip is rubber, not hard plastic. The resulting small amount of 'give' at the end of the flip's travel should help keep the flip from breaking if you drop the phone while it's open, or press it too hard against your head. It seems more like good design that a quality issue, because the flip actually has very little play and opens and closes very smoothly, i.e. its not 'el cheapo'. Additionally, there's a review up for the 8350 over at CNET, which, contrary to this one, praises the 8350's call quality/sound quality. They gave the phone an 8.3 or 'Excellent', and based on my experience, I'd have to agree. They also generally praised the camera, again, in contrast to this review. PhoneScoop user reviews have also been quite positive.
posted on Sep 29, 2007, 2:18 PM 0
5. Nate unregistered
My wife and I both got this phone after hearing good reviews of the 8300. To say the least, we have been very dissapointed with the reception of these phones. When a strong signal is available, there is no problem, but unfortanately, we don't have a strong signal at home. We have encountered numerous dropped calls and very bad reception in the two weeks that we have had these phones. We will be returning these phones.
posted on Oct 01, 2007, 12:13 PM 0
6. unregistered
2 other points of mension that they didn't talk about where there is no flash on the VX8350, why would you get rid of that? Also the plactice holster/belt clip who ever designed it needs to be slapped. On my VX4500, VX8100, VX7000 and the VX8300 you can open your phone with the holster attached. The VX8350 you have to remove the phone from the holster to open the phone
posted on Oct 10, 2007, 2:50 PM 0
7. Jo unregistered
I agree with the review. This phone does not live up to expectations. Sound quality is poor ... tinny and muffled. Camera is useless. Ergonomics and handling are not bad. Fits in pocket well.
posted on Oct 19, 2007, 9:25 PM 0
8. adam unregistered
I purchased the vx8350 about a week ago. Here's my take thus far. This is the first new phone I've bought in about 4 years. I've been using my LG3200 & comparing the 8350 to the 3200 this is what I think. First the 8350 is much more difficult to open, especially with one hand. The grooves dont allow for a quick open. Second, while the larger screen is nice, the size of the numbers is a little absurd, they are way to large for my liking & that doesnt allow for too much privacy, especially when punching in your voicemail pswd. Third, the number keypad uses white lights compared to the blue on the 3200. The blue lighted keypad in my opinion is much easier to see. Fourth, the position of the charger port is kind of a hassle. You have to remove that little rubber piece, but when you buy the phone, it's recommended you keep that little piece to prevent dust/dirt from getting inside the phone. That piece is so small, it'll be lost in a day. On the 3200, the charged plugs right into the side, no fuss. The 3200 also has a removable rubber piece (for a car charger). Fifth, the 3200 has about 35+ ring options from holiday tunes to a latin beat. The 8350 only has about 15+ & there's not much variety. Sixth, surprisingly, the battery life on my 3200 is out performing the 8350. Very disappointed in that. Seventh, similiar to the the ring tones, there is not alot of background pics as on the 3200. Bottom line is this: I'm not sure yet whether I'll wind up keeping the 8350. From a person who has had the same 3200 phone for a few years, I thought upgrading to the 8350 would be alot more sexy than it has turned out to be. I'm not that impressed & if my 3200 was still working perfectly after I dropped it in water, I'd probably still be using it.
posted on Dec 22, 2007, 10:11 AM 0
9. mark unregistered
I bought this phone to replace my vx4650. The maximum volume is less, and if the phone is sitting down, the volume will be reduced even more. I have found several bugs in the software. -If you are using the phone and receive a text, the action on the screen isn't necessarily what will happen when you press the button. -Pictures are correct if the phone is open, but are backwards (mirrored) if taken while the phone is closed. The image is reversed for the external display as well as for the file. -The dates of several appointments were corrupted. I could not change them (got an out of range error) and so had to delete and re-do. -certain mp3 files (high or variable bit rate) DO NOT SHOW UP on the player. Verizon's pc software does not catch these files. The phone now will shut off sometimes when it is snapped shut. It did not do this when new. Verizon's leather case SUCKS. It does not fit well. It covers the side buttons, making them very hard to hit accurately, especially when you can't see them. When open, the upper part slides up and covers the earpiece and camera. On my old phone, the case was almost impossible to put on or take off, but at least it stayed put!
posted on Jan 23, 2008, 12:24 AM 0
10. Myles unregistered
I just had to replace my broken 8300 with the 8350. I didn't want to but the people I was going through didn't have them in stock so they "upgraded" me. I thought the new version would be just like the old, but within 20 minutes of getting the 8350 I knew this phone would be terrible. I have to agree with others that the design is completely ridiculous. I enjoy the convienance of being able to flip open my phone with one hand, but the 8350 not only is a pain to open with both hands, but the cheap-feeling plastic slides around so you never feel like you have a firm grip on the thing. Who in the world designs a phone without a flash?? I thought maybe the camera doesn't need one due to some superior technology so I tried taking a few pics in a dark room and guess what? I got black pictures! Such a stupid design. My only comfort is that I may be able to sell the 8350 online, buy the 8300, and make a few extra bucks.
posted on Apr 03, 2008, 6:59 AM 0
11. Martha Morrison unregistered
I have had the LG 8350 for 5 months. My first phone broke at the hinge after 3 months. The replacement broke, in the same spot, after only 2 months. This is the 6th phone I have had in 12 years of cellular service. I am not hard or abusive with phones. This phone has cheap, weak hinges. The battery life is also very poor. With the new phone I get crackling occasionally. Compared to the 8300 I previously had, this phone is a piece of trash.
posted on Apr 16, 2008, 8:30 AM 0
21. bikegem
Posts: 1; Member since: Aug 30, 2008
I agree with this comment. The right hinge on mine broke 3 months after I bought it, and I am very easy on my phone. Verizon replaced it, after a lot of contentious discussion. Now, 4 months later the replacement broke. I am not going to replace it with this same phone. I am very frustrated.
posted on Aug 30, 2008, 9:58 PM 0
26. unregistered
Hinge is faulty, mine "also" broke in less than 3 months of ownership. I am hoping for some 'warranty' on this so I don't have to "buy" a new one!
posted on Oct 02, 2008, 6:50 AM 0
12. Wendy unregistered
I am so glad to see that I am not the only person with a problem with the hinge. My 1st LG 8350 broke on the right hinge (Facing) after two months of normal use, and the store replaced it cheerfully. My 2nd LG 8350 broke in the same EXACT place 2 months later ( so I have had an 8350 a total of 4 months,) only this time the Verizon store was combative at best. They said that no one else had experienced this problem with the hinge and that I must have done something to it. After MUCH heated conversation, they agreed to replace it without the $50 fee they were going to charge me and proceeded to tell me there is no known problem with this phone and that they would never replace it again. Lucky, the nice lady at the 1-800 number was more helpful and told me to call her if I had an issue again. I have taken pictures of the broken phone as proof for the next time this occurs-which is likely to happen. I am also not hard or abusive on my phones and even had a silicone cover on the phone just in case...to no avail. Please post if you have had a similiar problem.
posted on Apr 28, 2008, 8:39 AM 0
19. unregistered
Same problem. The hinge broke on the right side of the phone (facing front). I didn't drop the phone, only took it out of my pocket to see that there is a chunk missing out of the hinge. Could you post the picture? Going to the Verizon store to see what happens tomorrow...
posted on Aug 10, 2008, 7:21 PM 0
20. unregistered
Same problem at right hinge. I think it's because of the stress from opening phone with left hand.Very thin plastic.
posted on Aug 26, 2008, 9:30 AM 0
22. unregistered
Mine also broke on the right hinge. I took it out of my pocket this morning and it was stiff to open. I examined it and a chunk was missing from the right side. We'll see what Verizon will do......
posted on Sep 04, 2008, 9:45 AM 0
30. drsingh
Posts: 1; Member since: Jan 28, 2009
I had the similar problem…the first time right hinge broke within 3 months and now around 9 months later the replaced phone had the same problem…right hinge broke…I can say that I didn't apply any force or dropped the phone. Fist time I was able to get free replacement, but I don't know what will happen this time…can we apply customer rights…can we take some legal action??
posted on Jan 28, 2009, 11:09 PM 0
13. Holly C. unregistered
Have had this phone about 7 months. Several concerns. (Note: I basically use it as a phone, only occasionally for pix, not for music, not for emails, or online anything. So, from me this phone gets really minimal daily wear/tear use.) 1) Dumb that it doesn't have a flash if it's intended for picture-taking. 2) Outside buttons get pushed accidentally all the time just from slight movement within the confines of my purse or pocket. I don't even use these things except to check the date/time/and to see if there are any messages or missed calls without having to flip open. 3) Lately, last couple weeks, I've noticed the phone just shuts itself off! It's done this about 4 times, inexplicably. It is not the battery. I've cleaned the connection points. I have tried all manner of combinations of button pushing from the outside and cannot make it shut off that way. I can find no explanation on-line for this anomally which others have also had with this and with previous models. 4) Two-handed flip is awkward; should be able to do one-handed. 5) The manual for the thing is extremely cheap! Teeny-tiny print on teeny-tiny, flimsy pages. Come on! 6) The $40 bluetooth is a waste. No one can hear me when I use that thing. I will read a lot more reviews before buying my next phone.
posted on May 17, 2008, 8:53 AM 0
14. sna unregistered
I have dropped my LG VX8350 phone in water. It does not turn on, is it possible to retreive my contacts?
posted on May 17, 2008, 11:17 AM 0
16. Shawn M unregistered
My wife and I both purchased LG VX8350 phones about 1 1/2 years ago. I have had nothing but problems with the phone I have. It shuts off for no apparent reason. I have read above that others are having this same problem. The first phone I had, my wife took to the local office to have them look at the problem, and they gave her a brand new phone. That was all well and good and it worked fine for a little while. Then all of a sudden, guess what? Yep, it started shutting off on its own as well. Now the phone that my wife has, is beginning to do the same thing. It is really frustrating when you have to turn your phone off and on 4-5 times a day, not to mention missing phone calls and text messages due to it being off and me not knowing it. My wife went back to the local cell phone store today, and they tell her that they will give her a refurbished phone in place of the one we have. In my opinion that is like trading in a 87 chevy cavalier for a 08 chevy cavalier. I think they know this phone is junk and there is not much they can (or will) do about it. I have to give them a thumbs down for this particular phone. I am eligible for an upgrade at the end of August, so I will just sit it out and wait until upgrade time with a phone that shuts off several times a day. By the way, the local cell store here was told to keep their refurbished phone!!! Anyone thinking of getting the LG VX8350 I would highly recommend staying away from it, at least from what experiences I have been through.
posted on Jul 14, 2008, 3:21 PM 0
17. jmo unregistered
My 8350 shuts off when I close the flip, often 7/10 times. Not sure if closing the phone actually presses the power button off or if there is another issue. Will try another one as I like the phone otherwise.
posted on Jul 14, 2008, 9:29 PM 0
18. unregistered
Just got my 8350 - does anyone know a way to keep the outside LED display light on all the time?
posted on Jul 24, 2008, 7:49 AM 0
23. unregistered
This phone is fantastic. I can go a week before charging. Some of the reviews for this phone were that people thought it felt cheap and was hard to open with one hand. I have to disagree. It is a lighter weight phone but does not feel cheap. I have had no problem opening with one hand. The battery life is amazing. I guess those people never have a motorola phone, because the battery life is terrible and there are always problems. I am very happy with the lg8350 and would recommend to anyone.
posted on Sep 05, 2008, 1:23 PM 0
24. unregistered
My husband and I both got one of these phones in December 2007. In March, the hinge broke on mine. I've been limping along with it because I didn't buy the insurance. But today, my husband tells me that his broke too! So, we're going to go down to Verizon and see if we can get them to replace the phones. We've heard of other people having similar problems with this phone, so hopefully they will honor us as customers for the past 6 years!
posted on Sep 19, 2008, 12:12 PM 0
25. Justin_Orlando unregistered
I am on my 3rd LG VX8350 - first purchased in Feb 2008 - first one had defective speaker phone, replaced on day 2 with a brand new one, then I noticed it would randomly turn off after a call, usually only 1-2 times a week, but it's bad when I go hours wondering why my phone hasn't rang, then I check and it's off, I turn it on and I have voice mails and text messages, replaced about 2 weeks ago, new phone has now shut off at least twice in about 2 weeks. I guess it's time for phone #4? I LOVE LG, and only have had LG with Verizon, but I hope they will let me pay and upgrade to a better phone, I am tired of this.
posted on Sep 23, 2008, 3:08 PM 0
27. finnegan0322 unregistered
i have just receive a vx8350 from my aunt. and i am from the philippines. where do you put the sim card?
posted on Nov 14, 2008, 8:09 PM 0
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Sorafenib in Treating Patients With Refractory or Relapsed Acute Leukemia, Myelodysplastic Syndromes, or Blastic Phase Chronic Myelogenous Leukemia
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00217646
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : April 28, 2015
- Study Details
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- How to Read a Study Record
|Condition or disease
|Adult Acute Basophilic Leukemia Adult Acute Eosinophilic Leukemia Adult Acute Megakaryoblastic Leukemia Adult Acute Monoblastic Leukemia Adult Acute Monocytic Leukemia Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 Adult Acute Myeloid Leukemia With Maturation Adult Acute Myeloid Leukemia With Minimal Differentiation Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11 Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1 Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL Adult Acute Myeloid Leukemia Without Maturation Adult Acute Myelomonocytic Leukemia Adult Acute Promyelocytic Leukemia With t(15;17)(q22;q12); PML-RARA Adult Erythroleukemia Adult Pure Erythroid Leukemia Alkylating Agent-Related Acute Myeloid Leukemia Blastic Phase de Novo Myelodysplastic Syndrome Previously Treated Myelodysplastic Syndrome Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Secondary Myelodysplastic Syndrome
|Drug: Sorafenib Tosylate
|Phase 1
I. Determine the maximum tolerated dose of sorafenib when administered in two different schedules in patients with refractory or relapsed acute leukemia, myelodysplastic syndromes, or blastic phase chronic myelogenous leukemia.
II. Determine the dose-limiting toxicity of this drug in these patients.
I. Determine the clinical activity of this drug in these patients. II. Determine the biologic effect of this drug in these patients.
OUTLINE: This is a randomized, dose-escalation phase I study. Patients are randomized to 1 of 2 treatment arms.
Arm I: Patients receive oral sorafenib once or twice daily on days 1-5, 8-12, and 15-19.
Arm II: Patients receive oral sorafenib once or twice daily on days 1-14.
In both arms, treatment repeats every 21 days for up to 6 months in the absence of disease progression or unacceptable toxicity. Patients achieving complete remission or partial remission after 6 months may continue therapy at the discretion of the principal investigator.
In both arms, cohorts of 3-6 patients receive escalating doses of sorafenib until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. Up to 10 patients are treated at the MTD.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|36 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Phase I Study of BAY 43-9006 (NSC 724772) in Patients With Acute Leukemias, Myelodysplastic Syndromes and Chronic Myeloid Leukemia in Blast Phase
|Study Start Date :
|October 2005
|Actual Primary Completion Date :
|December 2010
Experimental: Arm I
Patients receive oral sorafenib once or twice daily on days 1-5, 8-12, and 15-19.
Drug: Sorafenib Tosylate
Given orally
Other Names:
Experimental: Arm II
Patients receive oral sorafenib once or twice daily on days 1-14.
Drug: Sorafenib Tosylate
Given orally
Other Names:
- Maximum tolerated dose (MTD) assessed by Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 [ Time Frame: 21 days ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Diagnosis of 1 of the following: Acute myeloid leukemia (Acute promyelocytic leukemia (M3) allowed provided patient has failed prior therapy with both tretinoin and arsenic alone or in combination); Acute lymphoblastic leukemia; Myelodysplastic syndromes; Blastic phase chronic myelogenous leukemia (Failed OR intolerant to imatinib mesylate)
- Must have failed prior therapy with >= 1 cytotoxic- or biologic-targeted agent (e.g., hypomethylating agents, farnesyl transferase inhibitors, thalidomide, or tyrosine kinase inhibitors); Any number of prior regimens allowed
- Performance status: ECOG 0-1
- ALT =< 2.5 times upper limit of normal
- Bilirubin =< 1.5 mg/dL
- Creatinine =< 2.0 mg/dL OR Creatinine clearance >= 60 mL/min
- Fertile patients must use effective contraception
- No psychiatric illness or social situation that would preclude study compliance
- Prior bone marrow transplantation allowed
- At least 2 weeks since prior cytotoxic agents OR at least 5 half-lives for non-cytotoxic agents in the absence of rapidly progressing disease
- At least 24 hours since prior hydrea for control of peripheral blood leukemia cell counts
- Hydroxyurea allowed up to 72 hours after start of therapy with sorafenib
- No persistent, chronic, clinically significant toxicities > grade 1 from prior chemotherapy
Exclusion Criteria:
- Cytopenias secondary to multilineage bone marrow failure allowed
- Ineligible for or not willing to undergo allogeneic stem cell transplantation OR no donor available
- Absolute blast count=< 20,000/mm^3 unless patient has documented fms-like tyrosine kinase 3 internal tandem duplication
- No evidence of bleeding diathesis (except due to low platelets associated with the primary disease)
- No New York Heart Association class III or IV congestive heart failure
- No uncontrolled hypertension (i.e., sustained systolic blood pressure [BP] >= 150 mm Hg or diastolic BP >= 90 mm Hg)
- No unstable angina pectoris
- No symptomatic cardiac arrhythmia requiring and not responding to medical intervention
- Not pregnant or nursing
- No history of allergic reaction attributed to compounds of similar chemical or biological composition to the study drug
- No swallowing dysfunction that would impede oral ingestion of tablets
- No active uncontrolled infection
- No other uncontrolled illness
- No prior sorafenib
- No other concurrent investigational or commercial agents, except for standard intrathecal chemotherapy for the treatment of isolated CNS leukemic involvement
- No other concurrent anticancer agents
- No concurrent combination antiretroviral therapy for HIV-positive patients
- No concurrent therapeutic anticoagulation (Concurrent prophylactic anticoagulation [i.e., low-dose warfarin, catheter flushing with heparin] of venous or arterial access devices allowed)
- No concurrent cytochrome P450 enzyme-inducing antiepileptic agents, including, but not limited to, any of the following: Phenytoin; Carbamazepine; Phenobarbital; Rifampin
- No concurrent Hypericum perforatum (St. John's wort)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00217646
|United States, Texas
|M D Anderson Cancer Center
|Houston, Texas, United States, 77030
|Principal Investigator:
|Jorge Cortes
|M.D. Anderson Cancer Center
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT00217646 History of Changes
|Other Study ID Numbers:
NCI-2009-00081 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
2004-0702 ( Other Identifier: M D Anderson Cancer Center )
6742 ( Other Identifier: CTEP )
P30CA016672 ( U.S. NIH Grant/Contract )
U01CA062461 ( U.S. NIH Grant/Contract )
|First Posted:
|September 22, 2005 Key Record Dates
|Last Update Posted:
|April 28, 2015
|Last Verified:
|February 2013
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Neoplasm Metastasis
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Blast Crisis
Leukemia, Promyelocytic, Acute
Leukemia, Monocytic, Acute
Leukemia, Myelomonocytic, Acute
Leukemia, Megakaryoblastic, Acute
Leukemia, Erythroblastic, Acute
Leukemia, Basophilic, Acute
Leukemia, Eosinophilic, Acute
Myelodysplastic Syndromes
Hypereosinophilic Syndrome
Pathologic Processes
Neoplasms by Histologic Type
Bone Marrow Diseases
Hematologic Diseases
Precancerous Conditions
Neoplastic Processes
Leukemia, Lymphoid
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases


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Boulevard Park Real Estate
Boulevard Park is one of several small neighborhoods situated in midtown Sacramento – all urban and uniquely alive, yet pleasant with plush trees canopying over charming, older, Victorian-esque homes.
Nestled in between New Era Park, Mansion Flats, and Marshall School, this distinctive "park" is discernable by the grassy medians on 21st and 22nd Streets, the only area in midtown with such strips. Once a race track at the turn of the 20th century, it is one of Sacramento's most carefully preserved historic neighborhoods, with many of its homes more than a century old and restored to pristine condition.
Sacramento Magazine notes that the neighborhood is reminiscent of San Francisco, ideal for "lovers of old architecture and haters of commuting." The fact is readily apparent by the care of which homes are kept (in no small part due to requirements from the planning agency and design and preservation board), as well as the number of pedestrians and bicycle shops. Neighbors are also known to come together for holiday gatherings, spaghetti dinners, and masquerade balls. A diligent and nurturing neighborhood association spearheads beautification projects, garage sales, National Night Out, and gifts to the senior center.
Boulevard Park is practically bubbling on weekends, as residents venture out and enjoy an early brunch or browse at the farmers market or not-so-occasional craft fair. While theatres, dance companies and galleries are bountiful in the midtown area, Boulevard Park is home to its own colorful, burgeoning businesses. New Roma Bakery sits on the E Street boundary of the neighborhood, while Old Soul at the Weatherstone Coffee & Trading Co. is a morning necessity for locals (and an all around cool, socially-conscious coffee shop).
Search for Homes in Boulevard Park, CAView all Boulevard Park listings
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Hello group!
We're using PATguard Elite 2 and getting an alert we need assistance trouble shooting in the software. The software is installed on WXP SP3 machine. We run a report called "Concise Latest Test Results" and the results are returned correctly. We close the results and run the report again and the following Alert pops up.
As the alert indicates, if you select YES, the application closes. If you select NO you're given another alert:
At this point, it doesn't matter which button you select the app doesn't close it just freezes on the screen.
Any ideas?


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Frank sings a lot about struggles, parents and even the almighty or lack thereof.
I wrote the poem below to flush out some of my thoughts. Hope Frank and other Frank fans might read it some day.
When there is space and time…
Awful things creep in my mind
Lingering at night in bed
My thoughts fill with dread
Running, spinning out of control
Is there purpose or life in my soul
To whom I blame and to whom I plead
All are chosen, not surprisingly, by me
My parents were happy and devout
They shined brilliant light all about
They did not preach and gave us space
To find footing in this precarious place
So Almighty, where is her and him in me
Why is the decision tough to choose to be happy
For greatness is not found in those you overcome
But in the joy and effort when your best is done
I speak often of low expectations from others
Pressuring myself also does not help to discover
that when I say Almighty, I should not look above
But in my own self, Almighty is there and she is love
My Poem: Now
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Electoral rolls and directories
The politics of the critical 1850s meant that manhood suffrage was essentially granted to the people of Australia at a much earlier period than elsewhere. As a consequence, the electoral rolls serve as a virtual census return of males from that period onwards. Women also gained suffrage at the beginning of the twentieth century, much earlier than their sisters overseas. Other lists of individuals can be found in the various directories published from the 1830s onwards. This seminar provides a guide to the nature, contents and location of the many electoral rolls and directories that have survived.
- 45/60 minutes – Powerpoint presentation
- Login to post comments


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The Beaumont Enterprise, recognized by the Texas State Historical Survey Committee as Southeast Texas' oldest business, has been serving the region since 1880. Since 1998, the Enterprise annually has been recognized as one of the top medium-sized newspapers in Texas and five other states.
The Enterprise is the sixth-largest of 15 daily Hearst newspapers. In addition to the daily newspaper in both print and electronic forms and the website beaumontenterprise.com, the Enterprise produces the weekly Jasper Newsboy, Hardin County News and Journal, as well as a bi-weekly real estate magazine and two monthly magazines, VIP and Lakecaster.


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Being four girls who look almost alike to the band...
Hold Me Closer || L.H98266170
- by Beautifully Hemmings
- Rating:
- Published: 30 Nov 2014
- Updated: 27 Sep 2015
- Status: In Progress
"Hold me closer Luke, you're all I have left." @copyright 2014. All rights reserved. This material may not be reproduced, displayed, modified, or distributed without the express prior written permission of the copyright holder. For permission contact Beautifully Hemmings on Movellas.com
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Students interested in the automotive field may choose from three programs, each addressing a different approach to this area.
- The Certificate program is offered primarily to prepare students for employment in the service segment of the automotive industry.
- The A.A.S. degree program in Automotive Technology is a four-semester sequence designed to prepare students for a career in the automotive field or for transfer to a vocational-technical program.
- The A.O.S. degree program is a four-semester curriculum consisting of 58 credit hours of automotive-related courses. It provides students with an opportunity to acquire skills in specialized phases of the automotive service industry unavailable to students in the Certificate or A.A.S. degree programs.


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WASHINGTON, Oct. 25 (UPI) -- The HealthCare.gov website will be running properly by December, giving uninsured Americans time to sign up for healthcare, a White House adviser said Friday.
QSSI, a main government contractor, has been assigned to oversee fixes to the website and will have the site fully functional by Nov. 30, said Jeff Zients, the newly appointed chief White House economic adviser, told reporters on a conference call.
"Over the last week we worked with a team of experts to conduct an assessment of the overall state of the HealthCare.gov site," Zients said. "We are confident that by the end of the November, HealthCare.gov will be smooth for the vast majority of users."
Applicants must enroll in the federal healthcare program by Dec. 15 to receive healthcare plans that will take effect Jan. 1, The Hill reported. HealthCare.gov opened Oct. 1 but many users reported problems including getting locked out of the website.
The House and Energy and Commerce Committee held a hearing Thursday on causes of the website's problems.
Representatives of the IT companies in charge of the project testified only two weeks of testing was conducted before the website went live, but said the testing should have been carried out months in advance, The Washington Post reported.
"It was not our decision to go live," said Cheryl Campbell, senior vice president of CGI Federal, one of the IT companies involved.
"The system just wasn't tested enough," said Julie Bataille, director communications for the Centers for Medicare & Medicaid Services. "We are putting into place a much more rigorous testing process now."


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German Court: ISP Must Not Block Access To Foreign Sites, Even If They Are Illegal
from the makes-a-change dept
Against a background where some European courts are telling ISPs that they must block access to certain sites (in Finland and the UK, for example), this news from Germany comes as a refreshing change (original German article in Der Spiegel):
Deutsche Telekom must allow access to online betting sites, even if they are illegal in Germany. So ruled the Cologne Administrative Court on Thursday.
This follows a decision in Düsseldorf at the end of last year, where a judge had ruled that Vodafone and Telekom were not responsible for the content of Web sites, because they played no role in selecting material, and therefore should not be forced to block access. Moreover, the latest judgment can be used as a precedent in similar cases, according to the Der Spiegel report.
Of course, this reasoning also applies in those jurisdictions where ISPs have been forced to censor sites. This emphasizes the contradictory rules that are being applied across the EU, and the fact that the law in this area is by no means settled.
Follow me @glynmoody on Twitter or identi.ca, and on Google+
Filed Under: betting, gambling, germany, site blocking


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Top Items:
Byron York / Washington Examiner:
Obama campaign struggles to explain 'revenge' remark — CINCINNATI — A seemingly offhand utterance from President Obama has turned into a major point of contention between the two campaigns, as Team Obama tries to explain what the president meant when he told a crowd of supporters that "Voting is the best revenge."
Discussion: Power Line and Riehl World News
John Hinderaker / Power Line: Obama's November Blunder
Jeremy Herb / Ballot Box:
Obama assails Romney on Jeep ads in Ohio — President Obama kicked off the final weekend of his reelection campaign at a rally in Ohio, where he continued to slam Mitt Romney for claiming Jeep was sending jobs to China. — At the first of his four campaign rallies Saturday …
Discussion: CNN and Taylor Marsh
Mark Murray / First Read:
Polls: Obama stays ahead in Ohio, deadlocked with Romney in Fla. — Three days until Election Day, President Barack Obama maintains his lead in the key battleground state of Ohio and is locked in a close contest with Republican presidential nominee Mitt Romney in Florida, according to new NBC News/Wall Street Journal/Marist polls.
Discussion: Battleground Watch, Prairie Weather, Taegan Goddard's …, Cheap Talk, National Review and CNN
Sandeep Baliga / Cheap Talk: More Romentum: Why Is Romney Campaigning In PA?
Katrina Trinko / National Review: Marist: Obama Leads in Florida, Ohio
Neil King Jr / Wall Street Journal:
Obama Holds Lead in Florida and Ohio Polls
Obama Holds Lead in Florida and Ohio Polls
Alexander Burns / Politico: Poll: Obama up 6 in Ohio, 2 in Fla.
Romney holds all-star Ohio rally
Romney holds all-star Ohio rally
Discussion: The Other McCain, The PJ Tatler and BREITBART.COM
Robert Stacy McCain / The Other McCain: SCENES FROM OHIO 'ALL-STAR' RALLY
Rick Moran / The PJ Tatler: Huge Romney Rally in Ohio Kicks Off Final Push
John Nolte / BREITBART.COM: OBAMA: VOTING 'BEST REVENGE' AGAINST ROMNEY
Cameron Joseph / Ballot Box:
Romney returns to NH, promising bipartisanship
Romney returns to NH, promising bipartisanship
Justin Sink / Ballot Box:
Romney surrogates fan out across US
Romney surrogates fan out across US
Discussion: The Hill, ABCNEWS, The PJ Tatler and ABCNEWS
Kyle Balluck / The Hill: Obama's 'revenge' comment reverberates on campaign trail
Shushannah Walshe / ABCNEWS: Paul Ryan Begins Final Sprint: 'We Believe in Change and Hope'
Rick Moran / The PJ Tatler: Romney: Vote for 'Love of Country' Not Revenge
Emily Friedman / ABCNEWS: Romney Holds Largest Rally Yet in Ohio
Exclusive: Christie was Mitt's first choice for VP — One of the most tantalizing subplots of the 2012 campaign has been the curious and sometimes controversial performances of New Jersey Gov. Chris Christie. Now, campaign insiders tell POLITICO that Christie was Mitt Romney's first choice …
Andre Tartar / New York Magazine: We Could've Had a Romney-Christie Ticket
Alex Alvarez / Mediaite: Chris Christie Was Romney's First Choice For VP
Doug Mataconis / Outside the Beltway: Report: Christie Was Romney's First Choice For VP
John Flowers / msnbc.com: Top Links: Romney's first choice for VP, his inability to throw a spiral and Christie incurs Murdoch's wrath
Robert Stein / Connecting.the.Dots: Good-bye to American Know-How?
Jen Chung / Gothamist: Obama-Loving Christie Was Romney's First Choice For VP, According To Politico
Brett LoGiurato / Business Insider: Rush Limbaugh Called Chris Christie A 'Greek Column' For Obama
Nate Silver / FiveThirtyEight:
Nov. 2: For Romney to Win, State Polls Must Be Statistically Biased — President Obama is now better than a 4-in-5 favorite to win the Electoral College, according to the FiveThirtyEight forecast. His chances of winning it increased to 83.7 percent on Friday, his highest figure since …
Discussion: PointOfLaw Forum, Battleground Watch, Business Insider, Roger Ailes and neo-neocon
Ted Frank / PointOfLaw Forum: My election prediction — 72 hours from election day! Who's going to win?
Keithbacker / Battleground Watch: Senator Sharon Angle Agrees With Nate Silver: Barack Obama has an 84% Chance of Winning
Joe Weisenthal / Business Insider: Nate Silver Took A Huge Shot Against Mainstream Political Pundits In His Latest Election Forecast
Prairie Weather:
Maybe it's the media we really need to put to a vote — The Washington Post — given the role it could play in the media — is a really unforgivably lousy rag with, admittedly, some good people writing for it. Why the paper is so bad is beyond this reader.
Discussion: The Reality-Based Community, The Agonist and Brad DeLong
Mark Kleiman / The Reality-Based Community: "Contempt for the electorate" — George Bernard Shaw once …
Steve Hynd / The Agonist: Our Useless Fourth Estate
J. Bradford DeLong / Brad DeLong: Prairie Weather Goes Tornado Mode on the Washington Post
Washington Post:
Mitt Romney's campaign insults voters
Mitt Romney's campaign insults voters
Mackenzie Weinger / Politico: WaPo eds: Romney campaign insults voters
Roger Simon / Politico:
'Swift-Boating' of Obama fails — Obama should have been destroyed by now. That was the plan. — He was going to be "Swift Boated" in this election, just like John Kerry was in 2004. — It would be about Benghazi, where on Sept. 11 of this year, U.S. Ambassador Christopher Stevens and three other Americans were killed.
Discussion: The Hinterland Gazette, Alan Colmes' Liberaland and Daily Kos
Stephen F. Hayes / Weekly Standard:
Mysteries of Benghazi — November 6 is not only Election Day, it's also the eight-week anniversary of the terrorist attacks on the U.S. consulate in Benghazi, Libya. — Regardless of which candidate wins, the American people deserve answers to the many unanswered questions about the attack …
Discussion: Wall Street Journal and Power Line
Rudy Giuliani Calls on Obama to Resign — Says he should quit over Libya, economy, and that McCain would have helped prevent the Benghazi attacks. — Zeke Miller — an hour ago — 20 responses
Discussion: American Power, Alan Colmes' Liberaland and The Other McCain
Donald Douglas / American Power: West Chester, Ohio: Mitt Romney 'All Star' Rally
Robert Stacy McCain / The Other McCain: WEST CHESTER, OHIO: MASSIVE CROWD FOR ROMNEY-RYAN RALLY
Ashley Killough / CNN:
In fiery speech, Giuliani calls on Obama to resign, faults him for Libya
In fiery speech, Giuliani calls on Obama to resign, faults him for Libya
Discussion: Hot Air, Mediaite, No More Mister Nice Blog, New York Magazine and The Moderate Voice
Erika Johnsen / Hot Air: Romney: Vote for love of country, not revenge
Alex Alvarez / Mediaite: Rudy Giuliani Calls On Obama To Resign, Citing 'Lies' And 'Incompetence' Regarding Libya
Steve M. / No More Mister Nice Blog: SOMETIMES, SPOTTING REPUBLICAN HYPOCRISY IS LIKE SHOOTING FISH IN A BARREL
The Fix:
Hurricane Sandy helped Obama politically, Karl Rove says — Hurricane Sandy's impact on the East Coast this week gave President Obama a political advantage during the final week of the campaign, Republican strategist Karl Rove said in an interview on Friday. — (Justin Sullivan/Getty Images)
Discussion: The Atlantic Online, Politico, The Stranger … and Balloon Juice
Robert Wright / The Atlantic Online: Things for Obama Supporters to Worry About
Donovan Slack / Politico: Rove: Sandy helped Obama
Charles Mudede / The Stranger …: Nate Silver: "Obama led in 19 battleground state polls today. Romney led in one."
Betty Cracker / Balloon Juice: GOP ROI: The Blossoming
Ronald Radosh / Weekly Standard:
A Story Told Before — Oliver Stone's recycled leftist history of the United States — Two years ago, Oliver Stone announced that he was preparing to make a documentary about recent American history. It premieres on the CBS-owned cable network Showtime on November 12. Titled
Noel Sheppard / NewsBusters.org blogs:
Bill Maher Warns Romney Supporters: 'Black People Know Who You Are and They Will Come After You' — Bill Maher on HBO's Real Time Friday might have said one of the most disgraceful things uttered during the 2012 campaign season. — "If you're thinking about voting for Mitt Romney …
Marc Caputo / Naked Politics:
Miami Herald FL Poll: Romney 51%-Obama 45% — Mitt Romney has maintained a solid lead over President Barack Obama in the latest Miami Herald/El Nuevo Herald poll of likely voters who favor the Republican by six percentage points. — Romney's strengths: independent voters and more crossover support …
Discussion: Battleground Watch
Keithbacker / Battleground Watch: Romney +6 in Florida — Mason-Dixon
Alex Leary / Tampa Bay Times:
Times/Bay News 9/Herald Florida Poll: Mitt Romney 51, Barack Obama 45
Times/Bay News 9/Herald Florida Poll: Mitt Romney 51, Barack Obama 45
Discussion: Guardian, Business Insider and Hot Air
Brett LoGiurato / Business Insider: Obama Still Has A Massive Lead In A New Ohio Poll
Ed Morrissey / Hot Air: Romney up 6 in Florida
Washington Post:
Virginia voter fraud case expands to focus on GOP firm — The investigation into the arrest of a man on charges of dumping voter registration forms last month in Harrisonburg, Va., has widened, with state officials probing whether a company tied to top Republican leaders had engaged …
Discussion: The BRAD BLOG, The Hinterland Gazette, msnbc.com, The Raw Story and KDVR.com
Brad Friedman / The BRAD BLOG: Criminal Investigation of GOP Voter Registration Worker Arrested for Destroying Forms in VA Expands …
Janet Shan / The Hinterland Gazette: Virginia Voter Fraud Case Expands to Focus on GOP Firm Strategic …
Morgan Whitaker / msnbc.com: Virginia voter fraud investigation expands to GOP operation
Kay Steiger / The Raw Story: Virginia voter fraud probe into GOP firm may include up to 40 voter registration employees
Josh Bernstein / KDVR.com: Exclusive: FBI questions owner of embattled voter registration firm
Jeremy Herb / Ballot Box:
Obama: Millions 'still picking up the pieces' — In his last weekend address before Election Day, President Obama opted not to mention the campaign, instead talking about the recovery efforts after Hurricane Sandy. — "This weekend, millions of our fellow Americans are still picking …
Gregory Wallace / CNN: Romney delivers Republican Party weekly address
Donovan Slack / Politico: Obama touts storm response effort
Ben Shapiro / BREITBART.COM:
Discussion: Crooks and Liars
Discussion: NewsBusters.org, NBC.com Entertainment News, The Huffington Post and Mediaite
Noel Sheppard / NewsBusters.org: NBC's Hurricane Sandy Telethon Never Once Mentions Obama
Jack Mirkinson / The Huffington Post: 'Fox And Friends' Attacks NBC's Sandy Benefit Concert: 'Is It A Concert For Obama?' (VIDEO)


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"Steve Jobs – the man was fallible" is what I wrote in October 2011. I guess it seems pretty innocent now – although there may some remnants of people who still feel offended by it – but, believe it or not, one year ago it actually triggered a small barrage of hate mail.
Since then, I have read or heard others describe him as a terrorist, an asshole, and a psychopath (which, given that many US presidents have been shown to have had psychopathic tendencies may not even be unlikely). Hey, all I said was that he was "fallible"!
But all these people, in the wake of calling him a terrorist, an asshole, or a psychopath, without exception, also described him as a genius. And a person who built the greatest company on earth, changing all of our daily lives in the process.
But, in fact, I am not so sure of that either…
I don't mean this as some lame attempt at a final insult – suggesting that he wasn't even responsible for building this great company – but as a genuine question: Would Apple have been equally great today if it hadn't been for Steve Jobs? And, honestly, I think that is not impossible. And that is because I am a Tolstoy fan.
Tolstoy, in War and Peace, using Napoleon as an example, had a very clear opinion of leadership. A leader "is just a banner, they hold aloft in the wind". "Napoleon thinks he commands a 100,000 men, but in reality, he follows them". Tolstoy thought that what drove the French into Russia was not the act of a single man – Napoleon – but the result of much greater, collective human forces. Those forces needed a spearhead, and that became Napoleon. But if it hadn't been him, someone else would have emerged to follow those forces as their leader. Because "The course of earthly happenings … depends on the combined volition of all who participate in those events, and … the influence of a Napoleon on the course of those events is purely superficial and imaginary".
Would Apple have become great without Steve Jobs, or would someone else have surfaced to spearhead and personify the combined volition of the people working in that area in that company at that point time? I think the answer might be yes.
But who knows? And I know I will never know. But I also know that pretty much every person who reads this piece thinks he or she knows that the answer is "no". "No, Apple would never have been this great without Steve Jobs". And nothing will ever change that. Because what Steve Jobs has going on Napoleon, is that he is dead. Or better, that he died before Apple's demise. Napoleon lived to see his armies defeated by the Russians, and by the forces commanded by the Duke of Wellington at Waterloo. People started to realize he wasn't such a superhuman genius as they once thought he was.
When Apple's performance will start to plunge (and I mean "when" and not "if") the Great Man Steve will not be there to blame.
And of course Apple will, one day, start to underperform. One day, it will be outcompeted by its rivals, and even lose their shareholders' money in the process (if alone for the simple reason that if it continues its current growth rate for another decade it will be more valuable than the rest of planet Earth combined, eyeing up dominance of the solar system next). It will fall. But then people will simply say that it wouldn't have happened had Steve Jobs still been around. Because he's their banner; their banner they hold aloft in the wind.


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Respiratory Therapist PRN Pediatric- VCH Respiratory Care
Your Role: Performs routine respiratory care procedures in the acute care, critical care and outpatient environment; perform respiratory care assessments and diagnostic testing procedures associated with respiratory care under occasional guidance. For more information regarding the physical requirements and environmental conditions for this job, please click here .
Position Qualifications:
Department/Unit Summary:
Vanderbilt Children's Hospital Respiratory Care Department will be the model upon which other departments both internal and external set their standards. Our staff will be empowered to achieve their fullest potential and we will collaborate to further advance the care of children in our hospital and community. We promote a safe environment for our customers.
We treat each other with respect and we value and reward our employees who are committed to our mission.
Vanderbilt's Respiratory Care Departmental Key Facts:
Click Here To View The VUMC Promise of Discovery
Discover Vanderbilt University Medical Center:
Located in Nashville, Tennessee, and operating at a global crossroads of teaching, discovery and patient care, VUMC is a community of individuals who come to work each day with the simple aim of changing the world. It is a place where your expertise will be valued, your knowledge expanded and your abilities challenged. It is a place where your diversity -- of culture, thinking, learning and leading -- is sought and celebrated. It is a place where employees know they are part of something that is bigger than themselves, take exceptional pride in their work and never settle for what was good enough yesterday. Vanderbilt's mission is to advance health and wellness through preeminent programs in patient care, education, and research.
VUMC Recent Accomplishments
Because we are committed to providing the best in patient care, education and research, we are proud of our recent accomplishments:


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Whimsy Baby Customs
UC016B The Hungry Caterpillar Children's Underwear Panel (Bamboo) - Sunday
Regular price $9.50
Children's underwear panels are 14 inches wide by 20 inches long. The main panel with the image and the coordinate are each 10 inches long, The actual image is about 3 inches wide. Printed on about 220 gsm cotton lycra.


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- Home
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- Contact Us
Rasayan is a Sanskrit word. It is a combination of two words rasa which means essence and ayana means path. It is a term which was used in Ancient times. It literally means the science of lengthening one's lifespan. It also refers to Indian alchemy. Rasayana helps in immunity development/anti ageing.
The Rasayan therapy is effective and it helps in preventing and curing diseases. The benefits do not stop there! It helps to enhance beauty, longevity and youthfulness. Any herb, diet, food or activity that helps in restoring vitality and enhances youthfulness is considered Rasayana. If you wish to get health benefits like immunity development/anti ageing, you should go for the Rasayana therapy.
Nobody wishes to grow old too soon. Rasayana can help you to stay young and it can also develop immunity. There are activities like yoga, meditation and prayer which are included in Rasayana therapy. A proper diet is prescribed in the Rasayana therapy.
The herbs and ingredients used in Rasayana are amla, haritaki, triphala, shilajit, brahmi, dhatri, amalki, etc.
We offer Panchkarma therapies which are beneficial for your body. SKK Ayurveda And Panchkarma offers therapies like Vaman (Induced vomiting), Virechan (Induced purgation), Vasti (Medicated enema), Nasyam (Nasal instilltion), Raktamokshan (Leech application) and many other treatments like Abhyangam(Keralian oil massage), Swedanam( Steam bath), Shirodhara, Kativasti, Jaanuvasti, Pichu, Podikizhi(Potli massage), Elakizhi(Patrapotali massage), Pizhichil( Oil bath), Udwarthanam, Netratarpan, Mukhlepam and much more.
The list of Ayurvedic therapies is endless. If you choose SKK Ayurveda And Panchkarma in Shadipur Depot, you will feel younger and stronger with our natural treatments.


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|Matthew Emmons/USA TODAY Sports
|Bill Belichick (left) has three Super Bowl rings, but he's lost his last two games on the big stage to Tom Coughlin.
The Mike Rice video made me sick. There's no place in athletics for that kind of abuse.
But I've had my fill of despicable coaching practices for this week. Let's shift focus to exemplary leaders of men, ranking the top coaches in the NFL, Schein Nine style. A nice, feel-good piece that will bring a smile to your face -- unless your coach didn't make the list or you passionately disagree with my order. I'm fascinated to get your take. Hit me on Twitter @AdamSchein.
Without further ado, my list of the nine best coaches in the NFL today:
1) Bill Belichick, New England Patriots
Sure, he made a big gaffe managing the game at the end of the first half on Championship Sunday. But don't get it twisted: Bill Belichick is the single best coach in sports today. I'd stack his résumé up against anyone else in pro sports in the last 25 years -- Phil Jackson, Joe Torre, Scotty Bowman, whoever -- factoring in his brilliance in New England and how he ran the Giants' defense under Bill Parcells. Belichick is 151-57 over 13 regular seasons in New England, going 17-7 in the playoffs while winning three Super Bowls and making five. And please, save the "What has he done since Spygate?" nonsense. Because the answer is double-digit wins every year.
2) Tom Coughlin, New York Giants
Like Belichick, he's a future Hall of Famer. Coughlin has two rings and gets his Giants to overachieve. He's a fantastic motivator and in-game coach.
3) Mike McCarthy, Green Bay Packers
It drives me nuts when I get calls on our SiriusXM radio show or tweets from haters who complain about McCarthy's play selection and lack of a run game. Last time I checked, he has Aaron Rodgers. And McCarthy's finger prints are all over Rodgers' development into becoming the best quarterback in the NFL -- from McCarthy's offseason quarterback school to his practices to the in-game play calling where Rodgers and McCarthy seemingly share a brain. McCarthy is a robust 74-38 as Packers head coach. He's done a great job assembling strong assistants, too. The Packers are always under the microscope and McCarthy handles the noise (think: Brett Favre) with aplomb.
4) Jim Harbaugh, San Francisco 49ers
I know he's only coached in the NFL for two seasons. But I also know how fantastic Harbaugh is, dating back to his days as a college head coach. In just two years on the job, Harbaugh has totally eradicated the Mike Singletary stench he inherited. Before Harbaugh arrived, the Niners were fodder for late-night talk shows, thanks to Singletary's ranting and raving. With Harbaugh, they're a featured attraction on primetime NFL games. Harbaugh is 24-7-1. He was a fumble away from the Super Bowl in his first year. He was yards away from winning the Super Bowl in his second year. He isn't afraid to make the tough decision, like changing quarterbacks midway through a season.
5) John Harbaugh, Baltimore Ravens
I know how this looks. Yes, John just beat Jim in Super Bowl XLVI. But Jim gets the nod with regular-season winning percentage and his immediate turnaround in San Francisco. Understand, I think John has been nothing short of brilliant steadying the ship in Baltimore -- putting his own stamp on the Ravens while managing Ray Lewis and Ed Reed. Let's not minimize that. Harbaugh is 54-26 in Baltimore. And he led the Ravens to a Super Bowl triumph -- keeping them focused through adversity, injury, Lewis' retirement announcement, the replacement of an offensive coordinator and other distractions -- despite the fact that at no point during the regular season did they resemble the best team in the NFL. Truly a tremendous accomplishment.
6) Mike Tomlin, Pittsburgh Steelers
Tomlin gets teams to out-kick their talent. With the exception of last season, Tomlin teams are mentally tough and play their best when it matters the most. He has the ring and the winning percentage to back it up.
7) Sean Payton, New Orleans Saints
He's back! If you ever doubted the greatness and importance of Payton, you saw it last year when New Orleans fell apart sans his leadership. Payton is aggressive and passionate -- qualities that are apparent in the way he coaches. He calls plays with that attitude and goes for it on fourth down. He conducts practices in that style. Thus, the Saints play with an edge and play for him.
8) Mike Shanahan, Washington Redskins
Even though I think he should've pulled Robert Griffin III at 14-0 in the first round of the playoffs to protect the franchise QB from further injury, Shanahan did a great job with Washington last year after struggling mightily in his first few seasons on the job. I still think he's an exceptional leader and I don't forget the championships he won in Denver.
9) Andy Reid, Kansas City Chiefs
The last two years in Philly were an abject failure, but let's not pretend the years prior didn't exist. He won seven division titles in the NFC East. The Eagles were a regular participant on Championship Sunday. Andy Reid changed and rescued Eagles football. The Chiefs have an elite head coach.
Toughest omissions: Jeff Fisher, St. Louis Rams; Mike Smith, Atlanta Falcons; John Fox, Denver Broncos; Pete Carroll, Seattle Seahawks.
Follow Adam Schein on Twitter @AdamSchein.


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Claire Danes, interior designer?
The "Homeland" actress says she considered a change of careers when she went through a stretch where she couldn't find a good role.
In an interview for Vogue's August issue, the 34-year-old says she didn't work for two years after starring in the 2010 biopic "Temple Grandin," which earned her an Emmy and Golden Globe. Danes said she couldn't just take any role after playing Grandin, an activist for autistics and animal rights.
Danes calls it a grim experience that left her so hurt that she flirted with a career change. Says Danes: "I really like interior design."
Of course, Danes didn't have leave acting. She landed the role of Carrie Mathison on "Homeland" and has won an Emmy and two Golden Globes.


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Ideas for composers for increasing the number of clips in their music library.
Would you like to have or need more clips of your production music along with a wider range of time lengths and potential applications for your music? Here are some relatively simple and good ideas.
One thing you can do is to use pieces of music that you already have as completed works. Let's say, for instance, that you have a five minute film score with a spacey ambient string section intro, a main full instrumental chord progression, a catchy melody theme, an energetic driving drum break, and a calm serene melodic interlude. It is not very difficult to have all these related individual sections edited into separate stand alone music clips. If you were to take for example the percussion break, this can easily be edited and turned into two individual clips, one as a percussion phrase with a distinct resolute ending and the other one as a loop.
Always remember you must be sure to check that the loop loops seamlessly before making it available for lease. All too often what sounds great in your audio editing software will have noticeable seams when actually looped. These loops can have noticeable clicks, timing errors, artifacts, or dynamic inconsistencies. It is always a good idea to make sure and check the rendered file before making it available for licensing! The same technique holds true for the chord progressions, ambient interludes, and melodies.
Two more benefits of this are:
1) the producer who is licensing your music can now have more options for time lengths and choices for dynamics of the original piece to use in their related project, and
2) you will have many more clips for a wider range of applications even if they are not related to the same end production.
Another way to have more clips can be by using different dynamics for the same passage. For example, one version can have only chord changes, another will have the melody line, and another without any percussion.
And yet another way is to make different time lengths of the same piece. One easy way to do this with MIDI produced tracks is by increasing or decreasing the tempo. For instance, a sixty second track at 60 beats per minute will become a thirty second track at 120 beats per minute. Yes, it will speed up the tempo but it does work for some things like ambient and certain kinds of melodic ambient and can have some interesting results. Of course there is always "copy and paste" too.
Well, I hope these suggestions will help a bit because they have worked for me!
Zoid Proteus "Interstellar Music"


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The Brak Show
Season 1
EP 1 Goldfish
Before going on vacation, Thundercleese asks Brak to take care of his beloved goldfish, Mr. Tickles. After Brak accidentally kills the goldfish, it appears in one of his dreams.
EP 2 War Next Door
After an altercation with a robot sent to kill Thundercleese, Zorak coughs up a lump from his throat. Miraculously, he now has a beautiful man-voice. The lump, whose name is Carmine, promises to make Zorak rich and famous.
EP 3 Time Machine
Instead of doing homework, Brak and Zorak waste their entire weekend playing video games. As punishment, Dad decides that they will not be allowed to go to Brak's favorite fish restaurant, Fishpockets. Desperate, Brak and Zorak try using Thundercleese's time machine to remedy the situation.
EP 4 Hippo
When Zorak catches Brak talking to a favorite stuffed doll, he pressures him into throwing it away. Brak grows depressed over losing the doll, but Mom remedies the situation by giving him a new one that she received from a gypsy. When Zorak catches Brak talking to it, he confiscates the new toy and faces surprising consequences.
EP 5 Bawk Ba Gawk
Right before the big game, Brak and Zorak decide to kidnap their high school mascot, a chicken named Mr. Bawkbagawk. Brak takes the mascot to his house to hide it and presents it to his parents as his father's uncle: Earl Toteman.
EP 6 Mobab
Zorak introduces his new friend Mobab, who immediately starts hitting on Mom, offering to take her on a trip. Because Mom wants to make Dad jealous, she agrees. Instead, Mobab kidnaps her and traps her in a cocoon. Dad and Brak must come up with a plan to free her.
EP 7 Expiration Day
Thundercleese's parent company, MoroccoBotix, Inc., deactivates him on his birthday. So depressed is Thundercleese that he stops caring for his yard, usually his pride and joy. When an asteroid is discovered to be on a collision course with their neighborhood, Brak and Dad need Thundercleese to save them.
EP 8 Psychoklahoma
Dad and Brak's favorite TV show is called "Senor Science." Senor Science himself is trapped in a block of ice, so he convinces Brak and Dad to purchase the Senor Science melting kit. Brak can't afford to pay for the melting kit, so he decides to raise the money with a play.
EP 9 The Eye
Dad used to be a master of the staring contest. Although he is retired, he accepts Zorak's staring contest challenge. Zorak loses because wasps, which are attracted to his eye juices, attack him. Later, Dad's most fearsome challenger re-appears: The Eye.
Season 2
EP 1 Poppy
Mom and Dad tell Brak about his late-grandfather, Poppy, who had quite a way with the ladies. Poppy sported a variety of noses for various occasions, so Mom gives Brak the nose that Poppy used to wear on dates. Brak is not very successful, however, especially after the nose starts giving him bad advice.
EP 2 Bully
Zorak sets up a booth and offers to give beatings to the neighborhood kids. One day a new bully forcefully takes over Zorak's booth. A distressed Zorak moves into Brak's room. Mom is so upset by the situation that she is moved to go out and beat up the new bully. Zorak gets his booth back and moves out of Brak's house.
EP 3 Mother, Did You Move My Chair?
Brak finds all kinds of excuses to skip school because he does not want to dissect a friendly clam. In his sleep, Spoonie, a talking wooden spoon, and Wunderbird, a yellow bird with a French accent, appear and promise to help Brak save the clam.
EP 4 President Dad
Dad gets upset with the neighborhood association and decides to run for its presidency. With the help of Brak and Zorak, he puts an ad in the newspaper filled with lies about the current president, Galrog. In retaliation, Galrog challenges Dad to a public debate.
EP 5 Pepper
Zorak falls for a new friend. Dad, meanwhile, is waiting for the "Mothership" to pick him up because he believes he is the "chosen one." When the Mothership finally arrives, however, it is Sisto who is taken. And Zorak learns that the object of his affection is part of the Mothership's crew and actually has a wife and kids!
EP 6 New Brak
A new pal begins to emulate Brak so much that he comes to be known as "the new Brak." Mom and Dad take a liking to the new Brak, which upsets the real Brak so much that he confronts the new Brak on his new Brak TV show. In the end, Ron Jaworski and Jim Plunkett show up in their football uniforms to prevent the Braks from coming to blows.
EP 7 The Feud
A feud erupts between Thundercleese and Dad after the two antagonize each other with yard-related mischief, including the freeing of Dad's pigs and the stealing of Thundercleese's yard bunnies.
EP 8 The Runaway
Space Ghost travels back in time to arrest Brak for crimes committed in the future.
EP 9 Brak Street
Brak raps his way into a rap contest with a badass rapper. Cee-lo guest stars.
EP 10 Dinner Party
The new neighbors invite Brak and family over for an evening of awkward conversation and murder.
EP 11 We Ski In Peace
It's "Take Your Son to Work Day" and Brak is bumming because his dad doesn't have a job. Also, giant ants.
Season 3
EP 1 Braklet, Prince of Spaceland
The Brak Family Players perform their rendition of "Hamlet".
EP 2 Coma
Dad helps Thundercleese win the hand of his true love.
EP 3 Shadows of Heat
Dad is now a secret agent. He solves a mystery of mind-boggling proportions.
EP 4 Enter the Hump
Dad and Brak visit the zoo, and Dad is bitten by a radioactive camel.
EP 5 Splat
Dad and Mom are involved in a car accident that could send them to prison.
EP 6 Sexy New Brak Show Go
A self-serving television producer gives Brak and family their own TV show.
EP 7 All That I Desire You
Romance and deception rule the day in this soapy send-up.
EP 8 Cardburkey
Brak decides that living in a cardboard box will land him an impressive girlfriend.


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The likes and dislikes of tenants when looking for a rental home have been revealed in a new survey.
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The number of landlords who are selling up their buy to let properties is at its highest since May 2018, a report reveals.
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The 'Fair Possessions Coalition' includes the National Landlords' Association, Arla Propert
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Nearly half of landlords say they will reduce or sell off all - their property investments in the private rental sector because of the potential removal of Section 21, research reveals.
The findings fr
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According to Commercial Trust, there's been a sharp rise in the number of
Landlords who are looking to enjoy greater rewards from their investment should look north of London, one index reveals.
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The number of deposit disputes that are reaching adjudication is falling thanks to early intervention.
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Nearly four in 10 landlords say they will sell-up if Section 21 is axed by the government, a survey reveals.
The survey was conducted by Landlord Action who found that 38% of buy to let landlords say they
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The Association of Independent Inventory C
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Foundation Home Loans says that most landlords who are looking to expand their portfolio over the next 12 months
Buy to let landlords who decide to abandon the market because of the government clampdown have been earning an average profit of £80,000 for each of the properties they sell.
Landlords in England and Wales last
Rents across most of England and Wales are continuing to increase, one report reveals.
The rental index published by Goodlord highlights that between March and April, the rents in six of the eight regi
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The Residential Land
The household hazards that buy to let landlords fail to address in their rental properties has been revealed.
The findings from property compliance firm VeriSmart from more than 60,000 property inspe
It appears that the days of amateur buy to let investors in the UK is coming to an end, lending figures reveal.
According to UK Finance, the banking trade association, banks advanced only a few dozen lo
Investor landlords in the south of England are looking North for better returns, one index reveals.
The findings from Your Move highlight that property yields in the North continue to outstrip other regions.
There has been a big jump in the number of landlords who are returning to the buy to let market after they have come to terms with the extra costs being imposed, says one estate agency.
According to haart, the legisla
London's landlords are increasingly buying outside of the capital
London's landlords are increasingly buying investment property outside of the capital, one lettings index has reveale
More than one in three property investors are calling for buy to let lenders to apply a manual underwriting process aimed at professional landlords, a new survey reveals.
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In a bid to protect tenants from 'rogue' landlords, Section 21 notices for eviction are to be scrapped, the government has announced.
In the announcement, the government says that Section 8 evictions will also be r
The UK's best buy to let hotspots have been revealed with the news that average rents grew in the year to March by 0.96%.
According to the research from Landbay, the best city for rental growth in that period w
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The growing exodus of landlords leaving the buy to let market has led to the highest number of tenants experiencing rent hikes since August, figures reveal.
According to Arla Propertymark, 34% of letting agent
The areas that have the highest rental demand from tenants in the UK have been revealed.
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The introduction of tough new laws covering energy efficiency for rental properties means one in three landlords cannot afford to upgrade, one organisation warns.
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Research has revealed that an investment in a buy to let property has outperformed just about every other major asset class over the past 10 years.
Most of this performance is down to increasing rental yie
Private rents rose by 1.1% in the year to February across the UK, the Office for National Statistics says.
The data reveals that, on a monthly basis, rents grew by 1%.
In England and Wales, rents rose by
Rogue landlords have been warned that they face legal action if they are found to be exploiting students, one government minister warns.
As new regulations to give tenants more power come into force, r
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