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Former New Zealand fast bowler Shane Bond is being targeted as a possible replacement for Damien Wright as New Zealand bowling coach.
Wright announced yesterday he is stepping down from the position to be closer to his sick mother and young family, and New Zealand Cricket director of cricket John Buchanan said they will approach Bond, Newstalk ZB reported.
"We'll go through the advertising process," Buchanan said. "We're aware that Damien Wright has to move on so we'll go through that process, but obviously someone like Shane Bond presents as one of the candidates that we're very interested in talking with.
"Obviously we're very disappointed to lose a quality coach like Damien but can totally understand his reasons for having to step away from the job."
Bond was recently sounded out for the vacant Canterbury coaching position but said he wasn't interested, citing his work that includes bowling coaching with NZC and Central Districts. He has worked with the likes of Doug Bracewell, Adam Milne and Hamish Bennett and would be a popular choice.
New Zealand Cricket will advertise the position this week.


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Taylor Swift and the Wormhole
Anna Schmitz
As with the wormhole, mostly I notice the absence. I notice the compliments that I used to receive and now don't. I notice the hair I used to have and now don't. I notice the water that I used to bathe in. Literally bathe in, a thought that feels ridiculous now. So much water that I could put it in a bowl and lie in the bowl of water and then let it all slide down the drain.
It wasn't the heat. It's hotter than it used to be, hotter than it was when I was crisscrossing the world in private planes (hotter than it was when planes still existed). But no, as it turned out, it was the universe collapsing. I don't know what happened, exactly, because since then there haven't been websites or newspapers or books. There's just what I can put together from what's still here.
As it turned out, it was the universe collapsing.
What's here, now: a nest of foam and stuffing where I sleep. The actual fabric grew mold, ate itself, became rank. I pulled it off after a few years. The plastic thread innards have remained mostly intact. The recording equipment, laughably, survived fine. Parts of it rusted in the first few years from water leaking inside, but it doesn't rain anymore. I made a small shrine to Olivia, who I ate after three months. To her credit, that was far later than the group who were in the recording studio with me. I killed them immediately. Some of their meat, preserved, is still left. Maybe enough for another seven or eight months.
All that―the meat, the jugs of water that I collected, the dried berries, the snack food that I've rationed―that's in the corner. I was always neat, and that hasn't changed. If anything, I've settled even more into myself. Maybe that's just an inevitable byproduct of aging. Maybe it would've happened even if the world hadn't folded into itself. Maybe not.
I made a small shrine to Olivia, who I ate after three months.
The byproduct of the folding winks at me from the corner. I don't know that it's a wormhole―I'm not a scientist. Maybe it's a black hole, or some other astrological anomaly. I don't know the difference. It's just infinity in the corner, and I'd like to think there's something on the other side. That's what I think the difference is, at least―that on the other side of a wormhole, there's more; and that there is no other side of a black hole. It's a question mark in the corner, an ellipsis. What if . . . ?
There is a life here. If you forget what it was like before, you can call it that. There are the berries, the meat, the diaries that I recorded. I grew tired of narrating after the first year because it was just an endless loop ("Woke up, climbed out, looked for food, came inside during the hot afternoon, ate, slept, ate, slept."). It no longer interested me, or made me feel better, or reminded me who I was. I'm still myself without the fans, still myself without listening to my own recorded voice, but I'm a different self.
The wormhole, for its part, remains the same. It's waiting for me to become someone who steps into a wormhole to see if there's anything on the side.
Instead, today, I ate my last granola bar.
Anna Schmitz lives in Minneapolis with her boyfriend and his tiny dog. She often says that she doesn't want any, and then eats half of yours off your plate.
Illustrated by Meghan Murphy.

subset: commoncrawl


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Good morning!
Time for a color challenge...yay!!
DRS stamps: Lighthouse 461G, Sailboat 887F, Summer Story 881C
I did a Bendi Frame card for this serene beach scene; the base (5 3/8" X 4 1/4") has the lighthouse and boat stamped on it, line drawn for a horizon and shoreline drawn in then boat and lighthouse masked and sky sponged in with clouds (I used a torn paper towel and sponged blue, moved the paper towel up and over and sponged blue again and so on until my sky was done).
I then colored in my water, sand and scene using a bit of white paint to make shine spots on the water. I used a palette knife and texture paste to make my waves then while the texture paste is still wet I added glitter to it.
I stamped my sentiment on another piece of white, die cut it into a circle and colored it yellow to be a sun in the sky...well, that was my intention.
I added a torn piece of tan paper on the base and added castle, shovels and bucket.
Now for the Bendi Frame part: I die cut the frame from a 5 1/2" X 4 1/4" piece of dark tan shimmer paper by picking a rectangle die the size I wanted my scene to be and then placed it in the center of my panel and there's my frame. Now I added more torn tan pieces to the back of the frame (creating dimension) and added the chair and palm trees. I threw the towel in with a tiny piece of stripe paper fringed at the bottom and glued to the arm of my chair. I also added coconuts using a hole punch and brown paper. The birds are glued to the base and one is popped up.
Now you can put your slightly larger frame onto your base. Put foam tape on the two SIDES of your frame (none on top or bottom); starting with one side at a time, stick your frame to the base by matching up the edges on the sides, this will create your bend because your frame is 1/8" larger than your card base.
This idea came from Kittie Caracciolo at KittieKraft. She does the most wonderful scenes.
The chair, birds, castle and beach toys are dies from I.O. and the palm trees die is from Joy! Crafts. The frame and circle stitched dies are from ODBD.
Thanks for visiting today!!
Please visit the DRS BLOG site to see all the designer's samples and to enter your own submission for a prize.


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SlowMov started as (and still is) a blog whose aim is to provide information about the food chain, the entire journey between a producer and what ends up in your cup and plates. And it is after a random meeting in Paris between one of its founders (Barcelona-born Carmen) and Antoine Netien from Coutume roasters that the idea of a physical space emerged. In May 2015 the SlowMov shop opened its doors in a quiet street Gràcia. More than a coffee shop, it revolves around a concept: to have a better understanding of where products come from and who is behind them. SlowMov promotes the consumption of locally produced and organic goods, and establish a contact between the consumers and the farmer or creator of the final product.
To suit that purpose, SlowMov is organised as a large and airy space where meetings are made easy by welcoming and friendly owners Francois and Carmen. Everything here such as infusions, honey or jam originates from less than 250km from Barcelona and coffee is roasted on-site on a Giesen W6 under the standards of renowned Parisian roaster Coutume, who only work with direct-trade coffees. Micro-roastery and food shop, SlowMov also showcase a few items by local independent designers. A cozy garden and a large communal table put an extra charm to this like-no-other place, where locals and coffee-geeks can enjoy espresso made on a Kees Van Der Westen and experience a single origin filter brewed with Aeropress, Chemex or batch brew, just besides the roasting machine. Coffee is therefore always very fresh and roasted in small batches, allowing SlowMov to offer a rotating variety of origins to choose from (beans from Burundi and Rwanda recently), creating an entertaining and educative coffee space.
Address : Carrer Luis Antunez 18
Closed Sunday & Monday
Instagram @slow.mov
photo credits : Albert Eritja


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Jeremy Côté is a home grown product of Victoria, BC, growing up and living in the western community of Metchosin for most of his life. He attended UVic and graduated from the School of Exercise, Physical, and Health Education with a degree in Kinesiology. After graduating, he moved north to balmy Fort St. John, BC for a three-year stint of Kinesiology at MC Rehab. He spent his time working with a variety of patients developing his clinical eye, skills, and experience. Jeremy sought out and pursued an impressive number of continuing education opportunities and has furnished himself with an excellent proficiency and skill set as a Kinesiologist. Jeremy loves working with people and helping them achieve their goals. Recognizing the value of working with a diverse and talented team made the choice to move back to Victoria and into Tall Tree Integrated Health Centre very easy and very exciting.
Professionally, Jeremy is unendingly enthusiastic about learning new approaches and skills to deepen his knowledge around how to help clients along their road to recovery. He performs a variety of assessments and treatments including Functional Capacity Evaluations, Soft Tissue Release therapy, fitness training, and specific exercise therapy for a number of conditions and populations. He believes in partnering with patients and motivating them to take their health to new heights. Sharing his knowledge, expertise, and positive approach, Jeremy is an excellent resource for his patients and for the clinic.
When the workday is finished, Jeremy enjoys an active lifestyle usually involving some combination of friends and competition. Living on Vancouver Island is a pleasure never lost to Jeremy, especially now that he's spent some time in Canada's northern climbs.


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Providenciales | Amanyara
BY: taylor methfessel & lauren machowsky SMARTFLYER
WHY: Girls Getaway
WHEN: Summer 2015
WHO: Lauren's daughter Lily
TYPE: Beach Resort.
ROOMS: Amanyara has a collection of sleek, sexy pavilions and private villas either offering a private pool, overlooking the clear blue waters of the coast or nestled into a corner of the marine reserve that sprawls throughout the property. Each pavilion overlooking the reserve has an overhanging terrace that jets out into the water where you can enjoy your breakfast, lunch or dinner in the privacy of the room. The hotel is perfectly minimalist and incredibly private.
POOL/GYM: Amanyara has an incredible infinity pool overlooking the Caribbean Sea. Settle on a day bed and stay to watch the sunset, while the sky's colors reflect in the pool's surface. The resort gym is fully equipped and private sessions with a personal trainer can be arranged. There are also onsite yoga and Pilates classes, tennis courts, a soccer field and complimentary guided hikes throughout the resort grounds. The hotel also has a golf simulator and a volleyball court.
RESTAURANT: The hotel restaurant provides many different dining settings. Our favorite place to have dinner was outside by the pool, underneath the stars. The food is Asian influenced and entrees feature freshly-caught seafood and organic vegetables from the hotel's vegetable garden. Lunch is at the casual Beach Club, which utilizes a stone oven to create innovative, Caribbean-inspired dishes. The wine list is one of the best that you'll find in the islands, featuring exotic wines from all over the world!
VIBE: Secluded and private, appealing to those who want to be a world away but can't travel far. Intimate, chic, romantic and quiet are all words that come to mind.
BAR: Evening cocktails are served in the open-air pavilion overlooking the infinity pool and emerald coastal waters. Drinks highlight fresh and local ingredients. Our favorite is the Basil Dazzle, a simple drink with just basil, vodka, lime and ice.
SPA: The spa is comprised of four spa pavilions surrounded by a reflection pond. From the moment you arrive, there is an immediate calming effect – you're transformed even before your treatment. The spa offers a variety of relaxing treatments and products utilizing the surrounding plants and herbs, harvesting their medicinal properties.
WIFI: Yes.
KIDS: Absolutely! Lily (Lauren's one-year-old daughter) was the guest of honor. Everywhere she went she was greeted with open arms and warm smiles. In-room amenities were incredible – inclusive of California baby products, a changing area, a crib with a stuffed friend and a diaper genie to make things even more pleasant. Kids meals were delicious and fresh. At night, babysitting services were offered.
LOCATION: The hotel is located on the west side of the island, just a 30-minute drive from the airport down a private dirt road.
For 2015 & 2016:
Upgrade on arrival (subject to availability)
Continental breakfast daily for two in room guests.
Complimentary à la carte lunch for two persons, once during stay
(excluding alcohol, taxes and gratuities)
Early check-in/late check-out (subject to availability)
Waking up at the resort feels like waking up in Thailand or Bali, surrounded by reflective pools, open-air structures and crystal clear water. Amanyara appeals to a variety of guests, whether it's a romantic honeymoon, a girl's trip or a family renting one of the property's large villas. It manages to be polished but laid-back and guests are encouraged to make themselves at home in any part of the property. The open-air pavilions and the gentle breeze create a sense of tranquility, which is a feeling present throughout your stay. Even at full occupancy, privacy and the quality of service are never sacrificed. The beach at Amanyara is pristine, and just in front is the renowned reef of Northwest Point Marine National Park. The hotel pool is equally gorgeous. The two of us spent the entire day lounging on the day beds, listening to the waves crash while sipping on mojitos.


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Ryan Grant might be getting healthy again for the Packers as he has busted lose for 75 yards already in the first half against the Bears defense. Grant has been slowed much of the year with a nagging hamstring injury after signing a huge off-season contract. So far this season Grant only has one 100 yard game against the Colts and two touchdowns. In comparison sixth round rookie running back Matt Forte of the Bears has 995 yards already and is leading all rookie backs. Both Grant and Forte are similar power running backs, however the younger Forte has more of a burst according to NFL analysts. Hopefully Grant will find his burst again as the Packers desperately need him to run a balanced offensive attack.
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Oh! my goodness me, people, these Peanut Butter Oatmeal Muffins!!! They are absolutely, unbelievably, completely and totally perfect! They're like a cross between an oatmeal muffin and a peanut butter cookie.
So crazy good! The kind of good that makes you want to get up in the middle of the night to gobble one down while no one is looking and then pretend that you were sleep walking if you ever got caught!
I know I pretty much say the same thing every time I come up with a new muffin recipe, but what can I say? I really have a thing for muffins. A really, really big thing. Leave an entire cake unattended in my fridge and I be like "meh, okay… whatever – anybody for some cake?"
But leave a dozen muffins and I totally lose all sense of self-control. I suddenly get obsessed and want to eat nothing but that until they're all gone.
Sometimes I think my obsession with muffins is so great that I oughta open up a little bakery shop where I would sell basically nothing but entirely naturally sweetened muffins, such as these guys. With all the different varieties that I've created as of now, I'd already have quite a great selection to offer, and sure would have a blast coming up with new flavor combinations every now and then!
I don't think that I'd have a hard time finding takers for my muffins either. After all, it IS really hard to find ready made muffins out there that aren't totally filled with TONS of fat, sugar and all kinds of other nasties…
The only problem is, I'm not sure I'm really cut out for that kind of work… getting up in the wee hours of the night to whip up batch after batch of muffins isn't exactly my idea of fun.
I'd much rather make my muffins "on order" (read: when I feel like it), in the comfort of my own kitchen — and then make friends with them, too!
Oh, and then share the recipes with you all, of course…
The first step requires that you preheat your oven to 425°F and line a 12 cup muffin pan with paper liners.
Next, in a large mixing bowl, combine some rolled oats, whole wheat flour, chopped peanuts, powdered peanut butter, baking powder, baking soda, cinnamon and salt and mix all that well with a flat whisk until all the ingredients are evenly combined.
Then, in a separate bowl, combine the peanut butter, date paste, honey, avocado oil (or other neutral tasting oil of your choice) and buttermilk..
Mix the wet ingredients together until they are very well combined.
No need to take out the heavy artillery here — no electricity will be required. Just a simple whisk will do the trick!
Now add the eggs, all at once. No need to add them one at a time and mix between addition, or for the eggs to be at room temperature either. Just dump 'em in and mix well.
Muffins are so uncomplicated and low maintenance! I think that's part of the reason why I love them so much!
Once the eggs have been well incorporated, throw in the dry ingredients, again, all in one go!
Now trade your whisk for a rubber spatula and fold in the dry ingredients until they are well incorporated but no more.
If like me you like BIG muffins, divide the batter between 12 large muffin cups. The batter WILL go way higher than the paper cups, so try and shape the tops into nice rounded domes. A large spring-loaded cookie scoop is the ideal tool for that.
If you preferred smaller muffins, or didn't feel too comfortable mounding the batter up so high, you could also make 18 to 24 smaller muffins instead. Of course, you'd need to adjust your baking time accordingly…
Lastly, sprinkle each muffin with a generous pinch of chopped peanuts.
Bake your muffins in the 425°F oven for 10 minutes, then lower the heat to 350°F and continue baking for 8-10 minutes (or a few minutes less if you decided to make smaller muffins) or until a toothpick inserted in the center of a muffin comes out clean.
Let the muffins cool in the pan for a few minutes then remove them to a cooling rack to cool completely.
Stored in a cool dry place in an airtight container, these muffins will keep for about a week.
Unless you have one of me around, in which case they will only last a couple of days… if you're lucky!
Oh, and if you're a true fan of peanut butter like me, try them warm with a little spread of creamy peanut butter…
OMG! I'm telling you: you'll want the moment to last forever!
- 1 cup (250g | 8.9oz) all natural creamy peanut butter (storebought or homemade)
- ½ cup (150g | 5.3oz) date paste
- ¼ cup (85g | 2.9oz) unpasteurized honey
- ¼ cup (60ml) avocado oil
- 2 cups (480ml) buttermilk
- 4 large eggs
- 2 cups (190g | 6.7oz) rolled oats
- 2 cups (280g | 9.9oz) whole wheat flour
- 1 cup (150g | 5.3oz) chopped peanuts
- ¼ cup (28g | 1oz) powdered peanut butter
- 1 tbsp baking powder
- 1-1/2 tsp baking soda
- 1 tbsp ground cinnamon
- 1 tsp salt (I use Himalayan salt)
- 3 tbsp chopped peanuts
- Preheat the oven to 425°F and line a 12 cup muffin pan with paper liners.
- In a large mixing bowl, combine the rolled oats, whole wheat flour, chopped peanuts, powdered peanut butter, baking powder, baking soda, cinnamon and salt and mix well with a flat whisk until evenly combined. Set aside.
- In a separate bowl, combine the peanut butter, date paste, honey, oil, buttermilk and avocado oil and mix well with a whisk.
- Add the eggs and whisk
- Throw in the dry ingredients and mix delicately with a rubber spatula until well incorporated but no more.
- Divide the batter between 12 large muffin cups. The batter will go way over the paper cup, so try and shape the tops into nice rounded domes. The use of a large spring-loaded cookie scoop is strongly recommended. Alternately, you could also divide the batter into 18 to 24 smaller muffins. Of course, you'd need to adjust cooking time accordingly.
- Sprinkle each muffin with chopped peanuts
- Bake in the 425°F oven for 10 minutes, then lower the heat to 350°F and continue baking for 8-10 minutes or until a toothpick inserted in the center of a muffin comes out clean. Let the muffins cool for a few minutes in the pan then remove to a cooling rack to cool completely.
- Store in a cool dry place in an airtight container for about a week.


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Click here to download the album on iTunes!
This year, 2015, marks the 35th anniversary of my first recording of original music. NALR released "Light of the World," in 1980, with 3 more recordings to follow before moving to OCP. The actual writing began a few years earlier, with some of those earliest works included here. The majority of this music is from the 1990 release, "Here With Us Now."
This recording is autobiographical on a number of levels, and includes my earliest and newest works. The cover of this CD is of the Watch Hill Light, in my hometown in Rhode Island. Its personal significance is due to me father's birth in the lighthouse—his father was employed there in the early 1900s, about the time that this post card was created. The beam of light is directed east on a straight line to Ireland, the home of my grandmother, who sailed into New York Harbor as a young girl. Since 2001, I have spent many weeks in Ireland singing, speaking, teaching, and visiting family and friends. My experiences there continue to shape my music and life.
I am also about to celebrate 30 years as music director of Christ the King Church in Kingston, RI. Most of my published music has been written for this community, one that continues to bless me and support my work.
I am eternally grateful for my family, my friends, and mentors along the way, John Limb and everyone at OCP, and especially all of you who support my work and affirm my decision, made back in 1972, to write music for the singing church. Thanks to OCP for letting me go back and re-imagine this music, and offering me a place to remain creative!
Finally, I am forever indebted to all of the singers of various ages and backgrounds who gave me an amazing sound that is exactly what I was hoping for...ageless! Thank you Jason Banta for your ears and patience!
And to Mary Carol, Carolyn, and Glenn....not sure where I would be without you!!


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You know the saying "can't leave well enough alone"? Well, that pretty much sums me up… in a decorative sense. It has always been difficult for me to leave things as they are and it's a serious struggle not to customize almost everything in some way. Anything from binders, text books, shirts, or my computer monitor… it has all been Adrianna-ified. When I get an idea in my head, I'm always on the look out for something that will work with whatever creative plan I'm stuck on. One of the big items on that list was a wheelie carry-on suitcase. It came to me after a few trips to the airport and seeing people with the same boring monotone wheel-on luggage. Browns and blacks were everywhere with nothing but luggage tape or plastic labels on the handle to identify one suitcase from the next. Then there would be the occasional "fun" one, but I always got into my head… hey, I can do better than that. This combined with how people put stickers on their guitar cases and laptops but as I don't play guitar and my laptop is already sufficiently customized, I needed another sticker-able surface. I remembered those antique briefcases that people sometimes put stickers and patches on, and thought, hey… I can just combine these two ideas! So the hunt was on. I was on the lookout for a reasonably good quality, fairly priced, hard surface, carry-on sized, wheelie suitcase that had flat sides (no ribbing or other unnecessary texture). It was harder than you'd think. So this past Christmas I received this one as a gift. It's a London Fog from the Wembley Lites Collection. The model is the 20″ Expandable Hardside Spinner Carry-On. My goal is to one day have an Earl Grey Tea Latte on my future travels so I can say that I'm having a London Fog with my London Fog. It would be even cooler if I was in London. And if it was foggy. This is what dreams are made of, everyone. It's a really nice suitcase and I was excited to start decorating! I had a few ideas, one was going with my original plan and covering it in stickers because God knows I have enough. The next was covering it in scrapbook paper (again, my scrapbooking shelves are bountiful), then I had some half-baked ideas involving vinyl and my Silhouette machine. But then I decided to go with the tried and true Archie Comic collage.
Archie Comics are something from my childhood that I hold quite close to my heart. I remember going to my cousins' house and looking through their impressive collection from the 70's and 80's and slowly growing my own in the 90's and early 2000's. Every time we'd go on a holiday I would get to pick one of the comics from the checkout when we were doing our last minute grocery shopping. I was Jughead one year for Halloween. I remember watching the animated TV show on Teletoon. And now I am very stoked for CW's Riverdale to air. For my artistic endeavours I couldn't bear to part with (and by that I mean savagely cut up) my own beloved collection, so I picked up some Archie Comics from Value Village. I spent a couple hours cutting out the individual comic boxes with a criteria of it having to display one of the main characters or at least be referencing them. I used the last of a large bottle of Mod Podge I've had hanging around for a couple years, and started a new one of the smaller containers. For application I picked a sponge brush instead of a paintbrush to avoid the visible lines from brush strokes. To make the process as easy as possible, I started by opening the suitcase and placing it face down on the floor so that both sides of the hard outer shell would be face up. I watched Gilmore Girls on Netflix to pass the time (my favourite kind of multi-tasking). I started on the back where the wheels were as I figured this would be a more difficult part. In order to make it look more professional, I tucked the corners of comics into the crevices between the matte plastic affixed to the wheel and the shiny, smooth plastic (it's actually polycarbonate… but we'll go with plastic haha) of the suitcase's surface. The process was mostly very repetitive. I used the sponge brush to apply Mod Podge to the surface of the suitcase, placed the comic, and sealed it with another coat of Mod Podge. I made sure that no black of the suitcase was showing by using an overlapping collage method. Other tricky areas were around the handle and the London Fog logo nameplate. The handle was especially tricky as the non-extendable handle fit very close to the top of the suitcase so it was difficult to maneuver it enough to get the comic pasted underneath without Mod Podging the rubber handle as well. RIP to that sponge brush. The foam tore a couple holes and and has almost entirely ripped off the handle so this was his final sailing, but he served me well over the years! The whole process took about nine hours from start to finish. I made a pretty big dent in season five of Gilmore Girls, the small bottle of Mod Podge, and probably my spine from hunching over. But hey, I'm really stoked with the result! I used this suitcase for my trip to Connecticut (you can check my photo-an-hour post HERE). I decorated my suitcase the night before (procrastination at it's finest) and got up to catch my flight three hours after I finished Mod Podging. I was very pleased with how well it held up with being crammed into four different overhead compartments, being pulled over the rough stones that make up Hartford's streets, and a bit of rain. Nothing has peeled off or been damaged, but I think I'll give it another quick sealing coat before putting him away into storage! Thanks so much for reading this post! I hope you enjoyed it!


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Debra Taylor
Debra is another of our award winning wedding officiants. She lives in London and as well as being a wedding officiant and accomplished public speaker, she is deeply into holistic health care. Debra is an active volunteer for charities and non-profits. She loves to golf and travel. Her energy, warm and inviting personality makes everyone comfortable immediately. She is flexible and open minded and has a great sense of humour. Debra celebrates all wedding ceremonies and would be honoured to not only participate in your wedding but to help you create a wedding ceremony that is unique and truly reflects who you are as a couple.Request Debra Taylor
Areas served
Aylmer, Dorchester, Dutton, Ingersoll, Lambeth, London, Lucan, Mount Brydges, Port Stanley, Ridgetown, St Mary's, St Thomas, Strathroy, Thamesford, Thamesville, Tillsonburg, West Lorne, Woodstock
Debra Taylor was professional, fun and caring. She went out of her way to adapt the ceremony to include our son. Our family and friends were also impressed with our beautiful ceremony and the personal touches Debra was able to incorporate.
Debra Taylor more then met our expectations. When we met with her before hand she understood what we wanted out of our ceremony and gave us lots of helpful hints to make it run smoothly. She was stright forward and specific with what she needed from us and what to expect from her. We really liked that.
Debra Taylor was wonderful. We had a wonderful initial meeting with her and felt very comfortable with her. The ceremony was beautiful. Debra was very supportive and assisted when we got a little emotional during our vows. We could not have asked for more. Thanks Debra for a great day. Our guests couldn't stop talking about what a wonderful emotional ceremony it was.
Debra Taylor was a perfect fit for us! She was full of energy and excitement, and helped keep our nerves at ease with her constant reassurance and guidance!
Thanks to Debra Taylor for an incredible ceremony. From the time I first spoke with her on the phone right up to the end of the ceremony she was supportive and so helpful, helping us every step of the way with a great sense of humor and a calming manner about her. Our guests were very complimentary of Debra and she really helped to make the ceremony an unforgettable one.
Debra Taylor was an absolutely wonderful officiant! She made us feel so comfortable, listened to what we wanted for our special day, and made us feel so important. It is clear that Debra takes pride in her job and makes the couple her number one priority. I cannot imagine our wedding being performed by anyone else. Thank you, Debra! You definitely helped make our day so special!
Debra Taylor was wonderful. When Debra showed up to do the wedding there were 4 other weddings going on the same day and she got directed to a different bride. This bride was stressing out really bad and Debra was able to calm her down and get her ready to walk down the isle. When she was finally directed to me she made me laugh because she told me what had just happened. She is truly a great lady to deal with. She is relaxed and down to earth. She makes you smile because she has a great personality, and is always smiling. I'm so happy we chose to go with Debra. She made our day just that much more special.
Debra Taylor went beyond our expectations! She went through every single detail beforehand to make sure we were well prepared. She gave us the idea to use the ring warming during the ceremony and it made our day that much more special. She has a calming and confident personality that was a perfect fit with our ceremony. The reservations staff were very helpful with every aspect. We will definitely be referring you to others
Debra Taylor was wonderful, performing our ceremony as we wished adding humour, love and family.
I was pleased with how easy it was to use your service. We were extremely pleased upon meeting Debra Taylor. She did a fantastic job, was on time and organized. She was a perfect match for us and we loved the service.
We can't thank Debra Taylor enough! She was so well spoken and organised, we received lots of nice comments from friends and family about how the ceremony was performed. We would highly recommend Debra to anyone, shetruly made our special day even more special. Thank you again.
Debra Taylor is an eloquent, well-spoken officiant who beautifully orchestrated our ceremony with grace, poise, vibrancy and love. After meeting with her in person, she knew exactly what verses would fit our personalities and energies for a non-denominational ceremony and our family, and wedding guests were overjoyed by her service. We HIGHLY recommend Debra to anyone who is looking for a wedding officiant. SIX Stars :)
Debra Taylor did an awesome job! The ceremony was beautiful and unique. Debra exceeded our expectations , we will recommend her for sure . Cody & Leah August 2019


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You know, it bothers me a lot less when a conservative tells me s/he thinks I'm wrong than when s/he says I'm unAmerican. Every time I even glance at the backlash against Obama's win, I come away with a sick horror. For all that I find a lot of the visible, frothing GOP to be OMG, WTF batshit, with a side order zealot-frosted krazykakes, I don't doubt that they're American. I totally understand disappointment, even fear (because I honestly do fear the GOP, not just on the front of human rights, but in how the GOP views America vs. the rest of the world,
deities above, below, and in the deep blue sea...), but I cannot understand, or condone the "America died" and "We should secede" rhetoric, much less the claims of we weren't divisive enough, WTF?. Aside from the obvious issues (sovereign nations provide their own currency, security, and such, that I doubt right wing separationists have thought of), it boggles me that that is somehow a rational response.
In a GOP win, I would have tried to fight within the system, supporting issues at a state level, even if they couldn't be managed at the federal level. I would campaign, and call, and argue one person at a time if necessary.
But I would never have called GOP supporters unAmerican. I would never have said Washinton, California, and Oregon should secede from the Union (despite the fact I'm fairly certain they could be self supporting as a group). Because, yeah, I think they're wrong in ways that matter deeply to me, but I don't think they're magically not American.
So... Dear GOP: Get Over Yourselves, because We're Americans Too.


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JAY Bothroyd today backed Carl Cort to get back to his best after injury - and insisted he'd be a wanted man if Wolves don't offer him a contract.
Cort is facing an uncertain time as he recovers from a recurring knee injury, as he is unlikely to play again before his three-and-a-half year contract runs out next summer.
But Bothroyd remains hopeful his striking colleague will wear a Wolves shirt again, admitting he will be missed over the remainder of the season.
"I'm desperately disappointed for Corty," said Bothroyd. "Having played up front with him I know he good he is to work with. He's a great target man, who takes defenders away and wins flick-ons which let me work in the areas I wanted to.
"He's a good player and now it looks like he'll be out for the season he'll definitely be missed.
"As to the contract situation, that's for Corty and the people upstairs to decide but I'm sure he's going to come back and be a force again. Whether that's here or somewhere else is open to question but I'd like to think it will be here.
"He's a quality player who can score goals and he's an honest player who is good to have around the dressing room."


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Today is an official snow day; the second in a row. As I peer outside, our world has transformed to a fluffy white winter wonderland of over 40 cm of snow. The official institutions of the world – schools, universities, city services – have declared themselves closed. So, our world is slowing down. We are staying close to home. We are having moments of stillness. Not by choice and yet it's a delectable indulgence. I've always loved snow storms as they do seem to mute the world. Everything gets quiet, calm and peaceful. This sense of quiet and stillness is so needed in the world. A forced day off helps us reconnect with the simplicity of just being. It's funny how uncomfortable people can be with stillness and quiet or forced solitude. Yet it's in these experiences that we can create some of the loveliest moments of our lives.
As a coach of high performing leaders, I often encourage them to take at least one day a month where they slow down, go quiet and be still. It's a hard request for many. However, those that make a commitment to this practice see a renewal of energy, a reconnection to their vision and a boost of creativity and inspiration. So, in future, I'll remember that for any resisters to this notion of stillness and quiet, I'll just invoke a snow day and let them discover the pleasures from there.
Snow angels anyone?


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Friday, 31 October 2008
Gummi´s Bistro
Thursday, 30 October 2008
Concertina Squid with balsamic butter, parsley and chilli
extra virgin olive oil
salt and pepper
125g butter
2 garlic cloves
1 red chilly, deseeded and finely sliced
5 tbsp parsley, finely chopped
1 tbsp balsamic vinegar
½ lemon, juiced
salt and white pepper
Take the squid and place a large cook´s knife or wooden spatula into its tube. Using another cook´s knife, slice the squid along its length at 1 cm intervals. As the second knife cuts down on to the knife the retains its ahape but also opens up in a fantastic way. Do the same to the remaining squid.
Add a little olive oil to a hot pan and fry the squid for about 2 minutes on each side and season with salt and pepper.
Take the squid off the pan and set aside. Add the butter to the pan and sweat the garlic, chilli, parsley with the balsamic vinegar. Season with white pepper, salt and lemon juice. Arrange the squid on each plate and pour the butter over. Serve with some boiled potatoes and green salad.
Saturday, 25 October 2008
Milky Cardamom Macaroni porridge
5dl macaroni
2tbsp sugar
1tsp vanilla extract
½ tsp cardamom
½ tsp nutmeg
Serve with some sugar and cinnamon.
Thursday, 23 October 2008
Spinach and Avocado Salad with Feta cheese
150g runner beans
1 red onion, thinly sliced
2 avocados, halved and the stone removed
150g feta cheese
3 tbsp olive oil
2 tbsp lemon juice
salt and pepper
Sunday, 19 October 2008
Oatmeal & Rhubarb Scones
3 tbsp baking powder
1 tsp salt
200g butter, chilled and cut into little cubes
½ cup granulated sugar
1 cup milk, full fat (nýmjólk)
200g oatmeal
2 eggs
1tsp vanilla extract
zest from 1 lemon
Combine the flour, oatmeal, baking powder and salt in a food processor. Cut the butter into the flour mixture and pulse together until it resembles a sandy flour. Pulse in the sugar. Now add the milk, vanilla extract and lemon zest. Pulse together until the dough just comes together and if the dough is too dry just add some milk.
Turn out onto a floured surface. Divide into two equal sized pieces and start rolling one at a time into a square 1cm thick. You want to keep the dough from sticking to the surface so sprinkle with some more flour if needed.
Slather the dough with the jam and fold the left side of the dough in toward the center and then the right side. Repeat with the other piece of dough. Both pieces will fit on one baking tray but give them a few centimeters between each other so they don´t bake into each other. Brush with a bit of cream or a beaten egg and bake for 25 minutes or until golden.
While the scones are baking, prepare the glaze. Combine the powdered sugar, lemon juice and lemon zest in a small bowl. Stir until well combined and set aside. When the scones come out of the oven brush them generously with the glaze and let cool. Slice into pieces as big or small as you like.
Friday, 17 October 2008
Asparagus and Gorgonzola Potato Quiche
5 sheets filo pastry
50g melted butter
600g potato, peeled
100g cheddar cheese
100g gryere cheese
100g gorgonzola cheese
300ml double cream
3 eggs
handful fresh sage, chopped
½ tsp nutmeg
salt and pepper
When the potatoes are ready, pour off the water and add the cheese to the potatoes in a bowl and mash together. Add the cream, nutmeg and season with salt and pepper. Add the eggs and work together with the potato.
Put the asparagus in some boiling salted water for a few minutes until half-cooked and then take them out of the water.
Pour the potato-cheese mix into the oven-proof dish, layer the asparagus over and scatter the sage on top. Brush everything with some melted butter and bake in the oven for 15-20 minutes.
Sunday, 12 October 2008
Lemon Meringue Pudding
60g butter
1 ½ dl sugar
grated zest and juice of 1 lemon
2 eggs , separated
1 dl flour
1tsp baking powder
3dl milk
for the meringue:
2 egg whites
40g unrefined sugar (hrásykur)
Preheat the oven to 180˚C. Wisp the yolks, sugar and lemon zest together until fluffy and smooth. Add the milk and lemon juice and whisk together.
Whisk the egg whites in another bowl until stiff and gently fold them together with the lemon mixture. Grease an ovenproof dish with some butter and pour in the mixture, then place it in a deep oven rack and fill in ½ of the way with water and bake for 45 minutes.
When the pudding is ready, make the meringue topping while the pudding cools down a bit. Whisk the egg whites with a little pinch of salt until it forms peaks, then add the sugar and continue to whisk until the sugar has dissolved. Spread the merang on top and run a brulée burner or a little blowtorch over to get the "baked-effect". Serve with some ice cream, whipped cream or vanilla mascarpone (seeds from 1 vanilla pod and 250g mascarpone cheese)
Tuesday, 7 October 2008
Lemon Brulée Tart
250g plain flour
125g butter
100g sugar
1 egg
Lemon Filling:
200ml double cream
180g sugar
6 eggs, (2 whole and 4 yolks only)
3 lemons, juiced
icing sugar – to dust
1. To make the pastry, put the butter and sugar in a food processor and whizz until combined. Add the egg and whizz for 30 seconds. Add the flour and process for a few seconds until the dough just comes together. Add a tbsp of milk if the dough seems too dry. Knead lightly on a flour dusted surface, then shape into flat disc, wrap with plastic foil and chill for 30 minutes.
2. Preheat the oven to 190C/fan 170C. Roll out the pastry evenly and line a 20 cm loose-based tart ring. Leave the excess pastry hanging over the edge. Line the pastry with tin foil or baking parchment and put a smaller oven-proof dish or some baking beans into the base, this will stop the bottom crust to rise. Bake blind for 15 minutes. Remove the foil and oven-proof dish or beans and bake for another 5 minutes or until the base is cooked and lightly golden brown.
3. whisk the eggs, yolks and sugar together in a bowl until fluffy. Stir in the cream. Finally add the lemon juce, this will thicken the cream.
4. Pour the filling in to the pastry case and place onto the bottom oven shelf. Bake for 50-60 minutes until the filling is almost set. It should be slightly wobbly in the center. Trim the pastry and leave it to cool completely. Dust with icing sugar and run a blowtorch or brulée-burner over the surface to give a brulée effect.
Sunday, 5 October 2008
Ice cold Mango Smoothie
2dl yoghurt
2dl milk
4tbsp fructose, or regular sugar
Put all the ingredients in a blender and pulse for 30 seconds until smooth. Serve ice cold. Holds in the fridge for 24 hours.
Thursday, 2 October 2008
Oven-baked Spaghetti with mushrooms
Serves 4-6
20g dry porchini mushrooms, (optional)
4 chicken breasts, cut into pieces
300g fresh mushrooms, sliced
2 cloves garlic, chopped
1 red onion, thinly sliced
2tbsp olive oil
2dl white wine, (or chicken stock)
5dl cream, (or sour-cream)
400g spaghetti
200g fresh parmesan cheese, grated
fresh basil, chopped
fresh sage, chopped
Preheat the oven to 200˚C.
Put the dried mushrooms in a bowl and pour 1dl of boiling water over, let in cool down for about 10 minutes.
Put the spaghetti in some boiling salted water.
Put some olive oil into a hot pan and fry the chicken until brown. Take the porchini mushrooms out of the water (but save the water) and add to the chicken along with the red onion, garlic and fresh mushrooms. Stir together.
Add the white wine and porchini water to the pan, lower the heat to medium and let it simmer for a few minutes until the chicken is cooked and the wine has reduced a little. Add the cream and let it simmer for another 2 minutes.
Pour the water off the spaghetti when it´s "al-dente" and add it to the chicken. Add ¾ of the parmesan cheese and all the fresh herbs and stir together. Grate the rest of the parmesan cheese over and bake in the oven in an oven-proof dish or the same pan (if it has a steel handle) until bubbly and golden (approx. 10-12 min)


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Occasionally, Beverly went out of town for the weekend and she would leave Maisy with me. At first, Maisy was a little confused because she hadn't really slept here overnight before. This resulted in Maisy not quite being able to settle in and get comfortable at first. But we all worked it out and she then became an old hand at weekend "Doggy Camp."
"The Saga"
Or "My Weekend at Lady's"
Dear Mom,
Well! What a nice long weekend I had. The first night was a bit odd because I didn't quite know where to sleep. Up. Down. Up. Down. Out to the living room. On the bed for 2 hours sleeping like a drunk on a street corner right next to Mattie. Then I was up again. What am I doing here? I don't sleep on beds!
Down. Now I settle on my little bed next to Lady's. Nope. Not good. Out to the living room. Not quite right. Up. Back to the bedroom. I finally settle on the cool tile in the bathroom under an open window. Best!
The next day, Lady looked like she lost her mind and Mattie, (you know…the short one…) and I got up at three! (?) Yeah! Well, not sure what that means, but it was early! Still dark out and stuff. Well, you know me; I could go out in a hurricane, so I made her happy and went. Yeah! And so it went.
One day it stormed. Lady couldn't believe it and was talking to a friend of hers on the phone and told her friend all the noise was "Thunder" and that it was "storming like a bastard". I didn't much like it and stayed in the office where I was away from the front door. I stayed there until the thunder and lightning went away. Then I popped right out like nothing happened. Lady didn't know I was afraid of storms. I don't' shake or anything. I just stay real quiet and stay away. But I'm always okay so I guess it was okay, so…okay!
The next night I learned that it was okay to sleep in the bedroom on my bed, as long as Lady didn't get up. But wow…we were up again real early. But I didn't mind because I was going out like …oh, I don't know…all the time I guess. I learned that it was really okay to nap and stuff. I didn't have to look at everything all the time.
So I got lots of brushings on my furs and I found many bones, and I went out. And I've been walking very nice next to Lady without my leash to take the garbage out. And then we go right back.
So between the garbage-taking-out, and the laundry-doing and the walking to the outside, I got a lot of mileage in.
It was really okay, Mom. I just sort of settled down and got to understand that I could just hang out and be myself. Oh, I did my jobs and stuff like I think I'm supposed to, but I can just not worry about stuff and I can nap and not wake up when Lady gets home from work. I mean, give me a break, last night I was up at 2! Yeah! It was "Daylight savings account time!" Yeah!
Lady was mad as a wet hen because it screwed her up and she said she couldn't sleep and now she is "dog-tired". Boy, don't I know about that!
But it was fun and I was a very good girl. Lady and Mattie and I got a nap in this afternoon, so it was okay. Lady said she had a head-ache but that would go away as soon as she got un-dehydrated from all the flyin'. Yeah!
So it was fun and I was fine. We watched movies and Lady tried to 'splain the plot to me, and I looked interested because I really don't care what she says to me, as long as she talks to me. And boy does she talk! Wow! But then when I get tired she is as quiet as a mouse and she even tells Parker and Pepper to "put a sock in it" because I'm getting a quick nap in. A couple of times she came home and I didn't even wake up. Boy, I sure am busy here! I get tired. But once I learned where I like to sleep, it was easy.
I sure do miss you and I'll see you when you get home. Thanks for the nice doggy-camp weekend and I hope you had as good a time as I did.


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These feedback and reviews are posted by REAL customers on our Facebook fan page, you can also view it in the link below:
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text:
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text:
So. This is Wicked:
Started: Aug 22
Finished: Sept 6
Yarn: STR Twisted in Turquoise, just under 1 1/2 skeins
Pattern: Wicked, by Zephyr Style
I was very happy to cast it on. And knit it. And finish it. But even after frogging it about halfway through and starting it again, the neck/chest is just too big, and I probably won't wear it. (That's a risk I understood going into the whole sweater-making endeavor -- I'm incredibly picky about what I leave the house in, even though probably nobody would guess by looking at me.) (Also... It seems to me like the Wicked silhouette is one that can be pulled off by a portion of the population that does not include people shaped like me.)
So, meh, whatever, it was really fun and I still love the yarn. So about three seconds pass after the photo shoot and I notice the still-big ball of leftover turquoise yarn. About two seconds after that, I start scheming. Just Enough Ruffles? A little shrug? Is that maybe enough for another sweater? (No.) Hmmmmmm.
Around the same time, I start my Christmas knitting* and the whole issue becomes moot. There the nice turquoise yarn sits.
With the passing time, and with each morning the decision not to wear Wicked occurring, my perception is changing. It's looking less like a sweater and more like an excellent source of some really awesome yarn that I could use to make a sweater!
Flair? Varese Hoodie? Lost in the Woods Hoodie? Probably I'd ditch the hood on either of the last two.
Does this make me a process knitter? I never thought I'd see the day. And maybe the fact that I want desperately to be wearing whatever new sweater comes out of this RIGHT NOW means that I'm still not -- I can just let go of a project more than I used to be able to.
*Mom, changed my mind. Fun fur 1/10th scale dinosaur is too big a commitment at this point. Will make you an intarsia steering wheel cover/gearshift cover/dashboard cozy instead. Don't despair, though, there will still be fun fur. Also, how do you feel about mushroom motifs?
What the note doesn't say is that even if you do, your family will be cursed with wool allergies for the next six hundred years.
So up until today, I was the picture of patience. Ordered on the 27th, shipped on the 28th. Delivered on the 2nd, which I learned when I finally gave in to impatience and went online to track the package. !@*%#!. KnitPicks was very kind to send out a duplicate order, so I guess the only thing I'm out is time, but still. That's a chunk of time. And some @##%### probably left the !$%# box in a dumpster, because what are they going to do with a box of yarn?
I'm also glad I didn't order everything I need for Christmas knitting, because that would have been a lot bigger order.
Now I'm off to sit by my mailbox with a sniper rifle.
Posted by MTB at 1:39 PM 1 comment:
Labels: yarn
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text:
What's better than finding an awesome new group of homeschoolers to celebrate pioneer day with?
For Ellie, it's making a great new friend in the process!
What's better than being silly with the missionaries when they drop by?
For Adam, it's discovering that there's no need to "grow a foot or two" before his mission, since he's already the same height as Sister Wright!
What's better than yet another day of non-humid summer weather with temps a good 10-15 degrees below where they normally are?
For Lara, it's yet another whole week of it!


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First prize in competition funded by U.S. and E.U. goes to drawing of Palestinian family holding AK-47 next to map of "Palestine" erasing Israel
Headline: "Ru'a Amjad – young talent rises in professional drawing"
"Seventeen-year-old student Ru'a Amjad from the Salfit High School for Girls won first place in the What is a Fighting Woman in Your Eyes? competition, which was organized by the [PLO -affiliated] Women's Affairs Technical Committee in partnership with the Salfit school…
It should be noted that the What is a Fighting Woman in Your Eyes? competition was held by the Women's Technical Affairs Committee as part of the youth initiatives that it is holding in 20 regions in the West Bank and Gaza Strip, in order to support the political participation of women. This is part of the My Right to [My] Future project, which is being held in partnership with the CARE organization (i.e., a relief organization with US governmental funding) and with European Union funding."
The article includes an image of Ru'a Amjad holding her drawing that won first place. The drawing shows the PA map of "Palestine" that presents all of Israel as "Palestine" together with the PA areas in the colors of the Palestinian flag, symbolizing political sovereignty over the entire area. Next to it a man, woman, and child are seen standing alongside an AK-47 assault rifle.
Mar. 29, 2017


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< TORVS Research Page
< CI Index Page
Textbook - Essentials
Learning Objectives
Interesting Websites
Comments Input-form
Textbook Comments
Representation of Chemical Compounds
Representation of Chemical Reactions
The Data
Structure Search Methods
Calculation of Physical and Chemical Data
Calculation of Structure Descriptors
Methods for Data Analysis
Representation of Chemical Compounds
Chemical structures can be transformed into a language for computer representation via line notations such as ROSDAL, SMILES, Sybyl.
Chemical structures can also be represented and handled in matrices or connection tables.
The constitution can be represented in an unambiguous and unique manner by canonicalization (Morgan Algorithm).
Ring perception and isomorphism are also very important for processing chemical compounds.
Molfile, SDfile, and PDB-file are the most well-known data exchange formats.
Stereochemistry can be represented graphically in 2D structures, but also by (permutations) descriptors. It is included in all line notations and exchange formats.
3D structures can be generated with fragment-based, data-based, and numerical methods.
Molecular surfaces can express various chemical and physical properties, such as electrostatic potential, atomic charges or hydrophobicity, using colored mapping.
Chemical structures can be visualized in various different models.
Many programs exist which can be used to generate and visualize molecular structures.
Representation of Chemical Reactions
The representation of a chemical reaction should include the connection table of all participating species (starting materials, reagents, solvents, catalysts, products) as well as information on reaction conditions (temperature, concentration, time, etc.) and observations (yield, reaction rates, heat of reaction, etc.).
However, reactions are only insufficiently represented by the structure of their starting materials and products.
It is essential to indicate also the reaction center and the bonds broken and made in a reaction - in essence, to specify how electrons are shifted during a reaction.
In this sense, the representation of chemical reactions should consider some essential features of a reaction mechanism.
Further insight into the driving forces of chemical reactions can be gained by considering essential physicochemical effects at the reaction center.
Specification of the reaction center is important for many queries to reaction databases.
Reaction types can be derived automatically through classification of reaction instances.
Reaction classification is an essential step in knowledge acquisition from reaction databases.
There are two fundamental approaches to automatic reaction classification: model-driven and data-driven methods.
The stereochemistry of reactions can be treated by means of permutation group theory.
The Data
Relationship of the data to the information and knowledge
How to prepare the data to learn from them
Evaluation of the complexity of a system
Data exchange and how to perform it
Data pre-processing
Data transformations
Variable and pattern selection in a dataset
Compilation of training, test, and control datasets
The hierarchical, network, relational, and object-oriented database models are the four most important ones.
They are classified into bibliographic, factual, and structure databases
The Chemical Abstracts (CA) File is the main abstracting and indexing service for biochemistry, chemistry, and chemical engineering.
Beilstein and Gmelin are the world's largest factual databases in chemistry.
The Cambridge Structural Database (CSD) and the Inorganic Crystal Structure Database (ICSD) contain information obtained from X-ray structure analysis.
Compounds are stored in structure and reaction databases as connection tables (CT), e.g., Beilstein, Gmelin, CAS Registry, and CASREACT.
INPADOC is the most comprehensive bibliographic database of scientific and technological patent documents.
Scientific and chemical information is becoming available increasingly on the Internet.
Structure Search Methods
A substructure search algorithm is usually the first step in the implementation of other important topological procedures for the analysis of chemical structures such as identification of equivalent atoms, determination of maximal common substructure, ring detection, calculation of topological indices, etc.
The search for structural fragments (substructures) is very important in medicinal chemistry, QSAR, spectroscopy and many other fields in the process of pharmacophore, chromophore or other -phore perceptions.
The similarity property principle states: "structurally similar molecules are expected to exhibit similar physical properties or biological activities"
Similarity search appears as an extremely useful tool for computer-aided structure elucidation as well as molecular design.
3D substructure search is usually known as pharmacophore searching in QSAR. In all of the 3D search methods the conformational flexibility creates considerable difficulties.
Calculation of Physical and Chemical Data
Additivity schemes allow the calculation of important molecular properties.
Additivity schemes for estimating molecular properties play an important role in chemical engineering.
The accuracy of an additivity scheme can be increased by going from atomic contributions through bond contributions to group contributions.
Heats of formation can be estimated with reasonable accuracy by additivity of group increments and corrections for ring effects.
Average binding energies from an additivity scheme can be used to recognize weak and strong binding of drugs to the corresponding receptor.
The PEOE method allows a rapid calculation of the charge distribution in s-bonded systems.
The PEOE method in conjunction with a modified Hückel molecular orbital (HMO) method allows charge calculation in conjugated p-systems.
Residual electronegativity values obtained by the PEOE method are useful quantitative measures of the inductive effect.
The polarizability effect can be calculated by a simple attenuation model.
Fundamental enthalpies of gas-phase reactions such as proton affinities or gas-phase acidities can be correlated with the values of the inductive and the polarizability effect.
Molecular mechanics calculations are a very useful tool for the spatial and energetic description of small molecules as well as macroscopic systems like proteins or DNA.
Current trends in ongoing development are in areas such as the treatment of polarization or applications to transition metal systems.
In combination with quantum mechanical methods, a QM/MM methodology allows the description of reaction mechanisms including whole enzymes.
Molecules should never be treated as static systems which are not able to undergo conformational changes.
Molecular dynamics simulations provide information about the motion of molecules, which facilitates the interpretation of experimental results and allows the statistically meaningful sampling of (thermodynamic) data.
The development of efficient algorithms and the sophisticated description of long-range electrostatic effects allow calculations on systems with 100 000 atoms and more, which address biochemical problems like membrane-bound protein complexes or the action of "molecular machines".
Calculation of Structure Descriptors
A structure descriptor is a mathematical representation of a molecule resulting from a procedure transforming the chemical information encoded within a symbolic representation of a molecule.
The abbreviation QSAR stands for quantitative structure-activity relationships. QSPR means quantitative structure-property relationships. As the properties of an organic compound usually cannot be predicted directly from its molecular structure, an indirect approach is used in order to tackle this problem. In the first step numerical descriptors encoding information about the molecular structure are calculated for a set of compounds. Secondly, statistical and artificial neural network models are used to predict the property or activity of interest, based on these descriptors or a suitable subset. A typical QSAR/QSPR study comprises the following steps: structure entry (or start from an existing structure database), descriptor calculation, descriptor selection, model building, model validation.
Molecules can be represented by structure descriptors in a hierarchic way with respect to a) the descriptor data type, and b) the molecular representation of the compound.
The QSAR methodology can also be applied to materials and mixtures where no structural information is available. Instead of descriptors derived from the compound's structure, various physicochemical properties, including spectra, can be used. In particular, spectra are valuable in this context as they reflect the structure in a sensitive way.
Methods for Data Analysis
Machine learning deals with the ability of machines or generally of computer programs to enhance their performance based on previous results. Machine learning can follow different learning strategies, e.g., supervised or unsupervised learning.
Decision trees give a graphical representation of a procedure for classification. They consist of nodes and branches; the leaf nodes give the classification of an instance.
Correlation analysis reveals the interdependence between variables. The statistical measure for the interdependence is the correlation coefficient.
Multiple linear regression (MLR) models a linear relationship between a dependent variable and one or more independent variables.
Principal Component Analysis (PCA) transforms a number of correlated variables into a smaller number of uncorrelated variables, the so-called principal components.
Principal Component Regression (PCR) is a combination of PCA and MLR: The scores gained by PCA are used for MLR.
PLS is a linear regression extension of PCA which is used to connect the information in two blocks of variables X and Y to each other. It can be applied even if the features are highly correlated.
Neural networks model the functionality of the brain. They learn from examples, whereby the weights of the neurons are adapted on the basis of training data.
A Kohonen network is a neural network which uses an unsupervised learning strategy. It can be used for, e.g., similarity perception, clustering, or classification tasks.
A counterpropagation neural network is a method for supervised learning which can be used for predictions.
A backpropagation neural network is also trained using a supervised learning strategy. The weights of neurons are adjusted so that the error of the output signal is minimized. A backpropagation neural network can be used for predictions.
Fuzzy logic extends the Boolean logic so as to handle information about truth values which are between "absolutely true" and "absolutely false".
Data mining provides methods for the extraction of implicit or hidden information from large data sets, and comprises procedures for the generation of reasonable and dependable secondary information.
Visual data mining allows the visualization and detection of hidden relationships in sets of data.
Expert systems, also called knowledge-based systems, use a knowledge base of human expertise and a so-called inference engine to solve problems. The inference engine contains strategies for using the information contained in the knowledge base to draw conclusions.
Building a QSPR model consists of three steps: descriptor calculation, descriptor analysis and optimization, and establishment of a mathematical relationship between descriptors and property.
Successful predictive models in toxicology exist - however, they are of a rather local nature. Effects considered in toxicology can be caused by different mechanisms. Efforts to get away from a class perspective to one that is more consistent regarding modes of toxic action are still a subject of ongoing research.
A proper representation of the molecular structure is crucial for the prediction of spectra. Fragment-based methods, topological descriptors, physicochemical descriptors, and 3D descriptors have been used for this endeavor.
NMR spectra have been predicted using quantum chemistry calculations, database searches, additive methods, regressions, and neural networks.
Several methods have been developed for establishing correlations between IR vibrational bands and substructure fragments. Counterpropagation neural networks were used to make predictions of the full spectra from RDF codes of the molecules.
Correlations between structure and mass spectra were established on the basis of multivariate analysis of the spectra, database searching, or the development of knowledge-based systems, some including explicit management of chemical reactions.
Robust implementations can currently propose correct structures from spectroscopic data, especially when the molecular formula and 13C NMR spectrum are available, or from 2D NMR spectra.
Reaction prediction treats chemical reactions in their forward direction, and synthesis design in their backward, retrosynthetic direction.
Reaction databases present a rich source of information for the extraction of knowledge for reaction prediction and synthesis design.
Reaction prediction, or reaction simulation, has to concentrate on the reaction center, i.e., the bonds broken and made in a reaction.
A reaction should be modeled as closely as possible to its mechanism.
The evaluation of chemical reactions can be performed to various levels of sophistication; heats of reaction allow for a consideration of the thermodynamics of a reaction, whereas reaction rates consider its kinetic aspects.
The more details of a reaction type are available, the better can be the modeling of a reaction of that type.
The evaluation of the impact of a chemical on the environment has to consider its degradation products also.
The metabolism of a potential drug has to be considered at an early phase of the drug development process.
Biochemical pathways and metabolic reaction networks have recently attracted much interest and are an active and rich field for research.
The disconnection approach has basically changed the view on planning a synthesis.
The retrosynthetic analysis of a target compound is a systematic approach in developing a synthesis plan starting with the target structure and working backward to available starting materials.
Several concepts for the implementation of synthesis design system have appeared since the early 1970s.
The drug discovery process comprises the following steps: a) target identification; b) target validation; c) lead finding (including design and synthesis of compound libraries as well as screening of compound libraries); d) lead optimization (searching for an acceptable pharmacokinetic profile, toxicity and mutagenicity); e) preclinical studies; f) clinical studies; g) drug approval (FDA approval).
A lead structure is "a representative of a compound series with sufficient potential (as measured by potency, selectivity, pharmacokinetics, physicochemical properties, absence of toxicity, and novelty) to progress to a full drug development program".
Chemoinformatics affects the lead finding and lead optimization steps within the drug discovery process. In particular the following tasks are involved:
analysis of HTS data,
similarity search,
design of combinatorial libraries,
design of focused libraries,
comparison of the similarity/diversity of libraries,
virtual screening,
de-novo design,
pharmacophore perception,
prediction of binding affinities, physicochemical properties (such as solubility, log P, pKa), and pharmacokinetic properties (ADMET profile),
establishment of QSAR models which can be interpreted and guide the further development of a new drug.
Following the "similar property" principle, structurally similar molecules are expected to exhibit similar properties or biological activities.
The term "Virtual screening" or "in-silico screening" is defined as the selection of compounds by evaluating their desirability in a computational model. The desirability comprises high potency, selectivity, appropriate pharmacokinetic properties, and favorable toxicology.
Lipinski's "Rule of Five":
molecular weight < 500,
lipophilicity (log P) < 5,
number of H-bond donors < 5,
number of H-bond acceptors (number of N+O) < 10,
(number of rotatable bonds < 10).
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Markus Sitzmann
Thomas Engel 2003
Contact: Thomas Engel
last update: 2003-10-19


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Using Self Help for Panic Attacks
Many times people that have a panic attack do not want to be treated with medication. They do not want to be placed on a pill everyday to keep them from having a panic attack. This is not unusual for anyone to do. They will not want to be controlled by any form of medication for the problem that they are going through.
There are different ways to use self-help when you are going through the problems that a panic attack can bring to you. Having the right state of mind to help you concentrate on how to feel better is going to be a great relief for many people. There are many self-help methods for panic attacks that are the same for controlling stress and other related emotional problems. There is no reason to be alarmed at this type of situation. You should not have to use a pill or any other type of medication to keep you on the right track.
Music Helps a Panic Situation
Using music to help you feel better is something that is going to be a good method. You can listen to your favorite music when you are feeling down or like you are going to have a panic attack. This can be any form of music that mellows you out. You want to feel good about yourself and get your thoughts and emotions under control before you lose it all together.
Another good idea is to take a walk or exercise. Burn out your frustrations and stress through this type of release. Getting a good workout is going to be essential to anyone that is looking to keep their mind clear and to get them straightened out so that they can let go of the fear of having a panic attack over something that is working on their mind and body. You can do this anytime of the day or night if you are feeling as if you are about to have an attack.
Write About your Feelings
Writing your feelings out on paper is another good way to get out your anxiety at the time. You can write down exactly how you are feeling so that you are feeling good about yourself. You will find that once you write down your feelings you will be able to release your anger and get yourself back on track. Think about the fact that you can write out your anger instead of yelling it aloud or keeping it bottled out.
Yelling is something that you can do if you are able to. You must make sure that you are away from others. You do not want to yell in front of others because they may in fact think that you are having a breakdown. You want to walk away from anyone and find as private area so that you are able to do your yelling and feel good the situation that you are in.
There is always something that you can do to make you feel good about yourself. You want to let the anger and the stress out so that you are not keeping it inside you and this will only make you feel worse. A panic attack is not going to affect a person all of the time. However, there will be times when you are not able to let the panic go and you will have to do whatever it takes to bring yourself to a calm and relaxed state of mind.
Living with a Panic Disorder
It is not unusual to have a panic disorder of some kind and still have a great and loving family. You can have the world when you are on the right type of treatment for your panic disorders. There is no reason why you have to give up on the life that you want and need so much. You should check into the different ways to get everything that you deserve and love when you are dealing with a panic disorder of any kind.
It is not the end of the world to be diagnosed with a panic attack disorder. You are not going to have to live out of your home for the rest of your life or distance yourself from those that you love because of it. You have the right to live your life the way that you want and to be happy. With a few different kinds of treatment out there today, you will be able to feel good about yourself and still have the regular life that you deserve.
Panic is a Common Problem
Being someone with a panic disorder is not a big ordeal. It is a very common problem among many people. Sometimes it is a scary situation and something that you have to learn a lot about before you are going to be able to move on past the feelings of being scared and worried that you are going to be affected by this diagnoses for the rest of your life.
You may be someone that has to live with the problem forever, but it should be something that you think about all the time. There are so many great forms of treatment out there that you will be able to have the family and friends that you have always dreamed about.
The main thing that you need to do when you are someone that is living with a panic disorder is talk to your doctors all the time. Let them know how you are doing ad if you are afraid of anything. If you are having problems with your panic disorder, you should talk to your doctor and let them know about the situation. Make sure that you tell them that you need some of form of treatment if something is not working out for you. They will be there for you and help you to be a happy and healthy individual living with a panic disorder one day at a time.
Panic and Your Love Life
So many problems come with the fact of having panic. When you are dealing with a panic attack in your life, you need to make sure that you are doing all that you can to keep your life under control so that you are living it to the fullest. You want to have everything that everyone else has and so much more. The main key to a happy life is to be able to do what you want.
Having a good love life is important to most people. Everyone wants to have someone to love. This will include anyone that has a panic attack. There is no reason to be left out when you are faced with dealing with the side effects of panic. If you want to be in a good relationship and have someone to love and not have to worry about anything ruining it, you should talk to your doctor. You are going to find that there are ways to make your life what you want and still have the love life that you are longing for.
Panic Attacks and Relationships
Panic should not be the cause of not having someone special in your life. If you want to have this kind of relationship, you need to work around your feelings of panic and do what you feel is going to be the best choice for you. Think about what you want in life. How is your panic affecting your life? If you are ready to make a change and do what is necessary to be in a healthy relationship, you need to be motivated to get to this point. Having someone to love and look after is going to be a great way to recover from the panic that is in your life.
Some people fear the intimate times in their relationship. They may panic because they fear that they are not going to make their partner happy. This issue may need to be worked out with therapy or even between the two people themselves. It is important to talk to each other and work these fears out before they get to be a void in the relationship.
Some people fear that they will always be alone. This is their worst fear and they may have panic attacks because of it. Working through these issues is going to be the only way that a person can be normal and have a good relationship that is strong and able to give them what they are looking for. Having the right medication and the most effective treatment is going to be the main key in getting exactly what you need out of life and living life to the fullest.
Panic Attacks and Sleep Problems
Panic attack is something that many people go through and it is not always fun. When you are dealing with this type of attack you need to make sure that you are keeping yourself healthy and able to move on. You need to do this so that you are not putting yourself at risk for something worse.
Panic attacks of any kinds can interfere with a person getting a good night's rest. This is something that can really damage a person because they are not going to be able to get the rest that they need to function for the upcoming day ahead. Having a panic attack can be very hard on the body and by not getting rest that is crucial; it is only going to make the situation much worse.
Taking the time to evaluate your situation and understand what your problems are is very important. You need to make sure that you are able to do what you can so that you are able get the panic attack under control and get on with a normal and happy lifestyle. You want to be able to get the sleep that you need to feel your best and to go about your normal lifestyle.
Think about the things that you really want out of life. Are you really getting them accomplished? Is your panic attack getting in the way of your everyday normal goals in life? If so, you need to figure out a plan to get treatment for your attack and to make yourself feel better about whom you are and what you are doing in life. You must be willing to make this work so that you are not setting yourself up for disappointment.
Panic and Tension Affect Sleep
When you are filled with panic, you are tensed up, and worried about something, this is only going to add to your problems. You are already going to have fears building up inside you and you may not be able to control them. When you are serious about getting help you need to talk to your health care professional and discuss the different treatments that are available for you.
Getting sleep is very crucial to be healthy and if you are not getting the sleep that you deserve, you are only going to make your life harder and add to the panic that is filling your body.
Taking the right medications for your sleeping problems is going to be necessary. You need to make sure that you are not taking the wrong medications for sleeping problems because this can only lead to more stress and anxiety building up in your body.
Panic Disorders and Money
Some people that deal with panic disorders may be afraid that they are not able to pay for the help that they need. A person that is dealing with a panic disorder is going to need to be aware that there is a lot of work to be done. They may need to speak to their doctor a lot in order to get the treatment that they are looking for. It is important to be aware of all the different treatments that are recommended for different people that are dealing with the disorders.
Having the ability to make sure that you are going to be able to get the help that you need with your panic disorders is important. If you do not have health insurance, you may want to talk to your welfare office to see if you can get assistance through them. Most of the time there are agencies out there that are able to help you get the medical care that is going to help you recover from your panic disorders and all that you are faced with.
Money is sometimes something that causes a person to have panic in their life in the first place. They may fear that they are not going to have money to live the life that they want to. Money is something that everyone wants to have but not everyone is able to have enough of it. This is going to cause stress in someone's life and can be the result of many panic attacks and fear. People may have to live with this type of panic in their life and not even know that they are dealing with a panic disorder that can be helped with the right treatment.
Find Methods of Support
There are also methods of support that you should turn to as well. You can find people that you are related to or friends that can offer you help through your difficult time. You should be able to talk to these people and feel good about knowing that you are not alone.
If you have no friends or family to lean on you can find help with support groups that are designed to help you get through the difficult times. You will be able to find this support helpful and get you feeling as if there is a way around panic and that you do not have to live with this disorder all of your life.
Money is the reason so many people go through stress. They will let money issues run their life and get them feeling down about themselves. It is important to realize that you need to be happy with what you have and not to let it get in the way of your happiness. If you find that money is causing panic in your life, you should talk to your doctor right away and get the help that you deserve the most.
Panic Attacks and Driving Ability
You may not think that someone with a panic attack would be able to drive a car. However, the fact is that yes, they can drive a car and take themselves where they need to be at anytime. It is not something that is going to be unusual for a person that goes through panic attacks to have a driver's license. This is going to be common and usually there is nothing to worry about at all.
The only thing that really worries doctors about a person that has a panic attack and driving is that they would not take their medication or treatment in some way. It is very crucial that anyone that wants to drive and deals with a panic attack gets the help that is required so that they are not putting themselves at risk along with others on the road too.
When you have a panic attack, you may get excited easily. This is going to be especially true for anyone that is on the road. Many things can come up on while driving that may upset a person. They may become worried that they are going to get into an accident or that they are going to get hurt. They may also worry that they are not going to be able to control the vehicle that they are driving and this may be the cause of a very serious accident.
Be in Control when Driving
Being able to be in control when driving with any type of panic attack is very important. You need to be the one that is in control always and that you are going to be able to keep the vehicle on the road and in a safe manner. There are many different types of medications that are very important in the help of getting someone ready for the road.
A person can also go through therapy and other important training courses to get them prepared for what is about to happen when they start driving. Sometimes it is a scary situation and it can be a very nerve racking one too. However, everyone that drives has the feeling of independence and importance and everyone should get to have this feeling in their life at some point.
It is ok to be worried about this at first. When you are someone that is dealing with a panic attack all the time, it is going to be a very upsetting and frustrating time in your life. However, it is very important to make sure that you are following your doctor's advice and taking the right medication when you are told. This will be the best way to keep yourself safe while on the road and to also be able to take on the daily challenges that driving can bring on. With medication and treatment, you will find driving to be a very easy and exciting task to do.
Panic Attacks in Children
A panic attack is something that can be found in many different people of all ages. Having a child that is dealing with a panic attack is not unusual. It will be very different in younger people than in adults. Children will tend to report the actual symptoms that they are feeling in their body rather than the emotional problems. Children that are in a panic attack may appear to be upset or scared with no explanation at all. This is going to be confusing to most people.
Children are not able to completely understand what is happening to them all the time. They are not sure what the problem is with their mind and body. Children will be very worried and confused at most times. It is up to the parents to watch their children closely and notice any problems that may be starting with them. Knowing what your child is going through is something that you need to do. You must be sympathetic to your child's condition and understand what they need from you and if they should see a doctor.
Panic Attacks can Lead to Problems Later
If a panic attack is left untreated in a child, it may bring a lot more problems to the child once they hit their adult years. There may be more feelings setting in and a child may never be able to recover from them completely. Having the ability to notice these problems from the start is going to be a great help and will get the child ready for later down the road. A panic attack can lead to many other problems for a child and give them feelings of destruction and anxiety for just about any reason.
Sometimes a child will have a panic attack when they are around others. Other children may worry them and being around too many at one time may not be a good idea. A child can become overwhelmed and worried when they are in this type of situation. A child may go into a panic attack when they are faced with fear in any type of situation. Getting child help is something that will be a big factor in getting a child under control when they are dealing with panic.
Usually children that get treatment for a panic attack will not have to deal with the problems all their life. With the right help when they are younger, they will not have the fear not all their life and the panic will be an issue for their adult life. Taking care of the situation in the beginning is going to be the best way to deal with a panic attack at any age.
Panic Disorders and Living with Pets
Having a panic disorder is something that many people go through. They have to figure out the best possible way to live with the panic disorder and to still have a happy and healthy life at the same time. This is not going to be easy and in fact, it is going to be something that is very scary and frustrating at the same time. However, anyone that has a panic disorder has to learn to live life to the fullest and be able to have everything that they want in life even if it includes a pet.
Having a pet and living with a panic disorder may be something that is hard to do. There are many people that do not like the fact that they have an animal in the house or the fact that they are messy or need to have attention to be happy and loved. Being able to have a pet when you are diagnosed with a panic disorder is very important. You need to follow through on the treatments that are so important and be able to do what you need to do so that you can have the pet that you have always wanted.
Being able to take care of a pet when you have a panic disorder is important. You have to make sure that you give the animal love, attention and feed them as they are needed. You need to do this all and still have to deal with the fact that you have a panic disorder. If your disorder is linked to pets and other animals, you may have to be careful with this type of problem. If you are getting a pet to help, you become more acquainted with the animals and to overcome your fear of pets, you may have to take this slowly and think about what you need to do first.
You should talk to your doctor or therapist and get the advice that is needed in this situation. You should make sure that you are doing what you should be doing in this type of situation so that you are not setting yourself up for a big problem later on. You need to be ready to take on the challenges of keeping your pet happy and healthy as well as fighting off your own fears of having this panic disorder with pets. Once you get on a good routine and figure out the right pattern that is going to help you the most, you will be able to be happy and have a great and loving friend in the pet that you take care of.


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Bristols handbuilt bike show, Europes finest bike show.
The UK Handbuilt Bicycle show.
- from Fri, Apr 7, 2017 at 2:00pm til Sun, Apr 9, 2017 at 4:30pm , Europes finest bike building show comes to Bristols Temple Meads...
Expect more cargobikes this year, Rodford Built had the first to be shown at the show in 2011, another first for our sister business.
They will be there with a variety of ideas and styles based on our versatile boxbike chassis and bring with them some of the developments that mean that you can now own a Rodford Built production boxbike of your very own..
go say say hello....go talk cargobikes..


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Smart Spring Tips
The American Home Shield is the nation's leading home warranty provider. They have some savvy tips about those DIY projects we all get excited about when the weather becomes warm.
Itching to spend your tax return to get going on spring DIY projects around the house? Well, you may want to slow your roll – a recent survey from American Home Shield's network of home contractors found that some DIY projects are better left to the pros. Nearly three-out-of-five (that's a whopping 60%!) of American Home Shield's network of contractors surveyed reveal they are often called in to fix homeowners' DIY repair attempts to major systems or appliances.
Thankfully, there are better ways to spend your tax return that will save you plenty of $$ down the line. Check out these tips from Dave Quandt, VP of operations at American Home Shield:
- Purchase (and actually program!) a smart thermostat: Most people don't program their thermostats because it can be complicated. With this one step you can save up to $180 each year on your energy bills. Many smart thermostats can be paired with an app from the iOS app store, enabling you to set temperatures, schedules and see both indoor and outdoor humidity from your phone.
- Install window treatments: Energy-efficient window treatments and coverings, such as blinds, shades and films, can slash the amount of heat that enters your home when the temperatures rise.
- Invest in a home warranty: A home warranty can help protect your budget when you're faced with unexpected home appliance and system breakdowns, saving major headaches down the line.


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Cadix Planter Rect. Low II 88X28X28 Black (FIT962)
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