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Irvine Plastic surgeon compares Silicone and Saline Implants
In a previous article we referred to the annual ASPS statistics regarding plastic surgery for 2013. These stats showed that silicone implants were used in an impressive 72{f4e1575822752660c3387461b06f16047197db710b64f29e8565d582c3a8cd4f} of breast augmentation procedures while only 28{f4e1575822752660c3387461b06f16047197db710b64f29e8565d582c3a8cd4f} used saline implants. Now, Dr. Andrew Smith, an Irvine board certified plastic surgeon specialized in Breast Augmentation, explains the reasons behind this powerful trend.
According to Dr. Smith the main advantage of Silicone implants is that these implants succeeded to look natural while at the same moment they present much less complications comparing to the past! Dr. Smith states "Since being reapproved by the FDA in 2006, silicone implants have consistently improved year after year," and adds "Today's anatomically shaped cohesive gel models look and feel more natural than ever, which has swayed a lot of women who may have been unsure about getting implants in the past."
But why 28{f4e1575822752660c3387461b06f16047197db710b64f29e8565d582c3a8cd4f} of the patients opt for saline implants! The main advantage of Saline Implants lies in the fact that IF a silicone implant gets raptured it must be removed while saline implants can be simply absorbed by the body. At the same moment saline implants are allowed for 18 year-old patients which gives them another benefit. Dr. Smith says "Although silicone implants are more popular, saline implants still have a place in the conversation," he says. "Saline implants are approved for patients as young as 18, so they tend to be popular with younger women. And they're better suited to patients who have good existing tissue coverage."
Like with everything else in cosmetics/plastic surgery choice depends on the patient's requirements. We at LipoAdvisor.com believe that safety should be top priority while aesthetic result, cost and other paremeters should be seriously evaluated.
PS: Dr. Galumbeck had recently published a detailed comparison on these types of implants – find it here!
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The Festival of Hexagons is almost upon us. I can't wait to share my tutorial with you all and to see what you have made. Don't forget to add your hexy projects to our Flickr Pool. There's also a Hexagons group over on Threadbias where you can add your projects too.
As you may have noticed, there will be a linky party at the end of the Festival. There are $200 in prizes from Fat Quarter Shop!!!
Aug. 13 - Aug. 24: Blog Hop Tutorials
Aug. 27 - Sept. 2 : Link Party
Festival of Hexagons Link Party
1. You may enter a maximum of two projects into the linky party.
Each project must have it's own blog/Flickr/Threadbias post and link.
2. This is a HEXAGON event -- projects must use HEXAGONS in
at least 75% of the overall design.
3. Projects must have been completed within the last 6 months.
4. Everything goes! this linky party is for all things
sewn -- quilts, pillows, bags, home decor, etc.
5. NO size restrictions -- have fun!
I'll see you all back here next Monday, August 13, for the kick off and my tutorial!

subset: commoncrawl


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spotted at sandra rose
spotted at sandra rose
T.O. is a guy who does a lot of things that go beyond football. Here's an example of one:
NFL star Terrell Owens walked the runway at Richie Rich and Pamela Anderson's Amuse fashion show as part of the Mercedes-Benz NY Fashion Week in Bryant Park, NY.
Borat learns Cricket
Borat learns Football
Borat Wrestles


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Beauty Notes: All makeup by Dior Beauty.
I Came All The Way and There's Not Even a Cake?
by flaunt
Photographed by Franck Sauvaire
Photographer: Franck Sauvaire at FranckSauvaire.com. Stylist: Maria Serra. Model: Erika Pattison for SelectModel.com, London. Hair: Paul Donovan for BumbleandBumble.com. Makeup: Lyz Marsden for Caren.co.uk using NARS Cosmetics. Photography Assistant: Anna Michell. Hair Assistant: Holly Rose Hawgood.


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Event Diary
We have an amazing array of PTA events coming up and we'll soon be updating this page. . Whether its for the whole family or a evening out with friends you be assured that they will be loads of fun.
Over the next few months we will be running a number of fantastic events and many more are being planned for 2019/20
We hope that you will be able to come along to support St John's PTA at these fabulous events and help us raise much needed funds for our school.
As you may know, each event is very much reliant on our wonderful parent volunteers - so if you would like to help with any these events, or maybe coordinate an one yourself, please contact a member of PTA.
For each of these events, near the time, we will send out more details either in your child's book bag/bag or through the weekly news on Parent Mail. We are always in need of volunteers and if you would like to help with any of the events please come and see one of our PTA members, your class representative or drop your details in the white PTA box out side the school office.


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— What I do and how I can help you!
— About
I'm Christopher Ellington, brand and portrait photographer & videographer. Let's talk!
So yes, I am a photographer and videographer based out of Fairfield County Connecticut. Brand portraits has long been a passion of mine. I've had the privilege to share this with individuals like yourself to exhibit your brand personality and professionalism for any platform important to you. My decade-plus professional background as a Creative Art Director in marketing and portrait wedding photographer has led me to this. You are your brand. It's your differentiator that gets your platform, business or talent noticed. I believe I can help you!
Are you a start-up business executive, blogger, musical artist, personal trainer, actor, aspiring model, pastor, chef, public speaker or entertainment personality? I know how important it is to be taken seriously, professionally and passionately to succeed. There are many ways to accomplish that, I just so happen to specialize in providing you visual representation. You'll walk away with a series of portraits and creative images suitable for social media teasers, appropriately shot visuals for your website development and marketing material. How does that sound?
Even weddings have become synonymous with branding. For some, it's solely about capturing the events of the day. For others, it's evolved into a creative expression of a life sought with each other. I think that's a beautiful thing. What about you? Let me know how I can help immortalize that!
My desire is to bring the best out of people; to capture a side one never expected to see and help you proudly display it. It's absolutely priceless to me.
"Oh, wow that's hot!"
"Who's that good looking person? Is that me?"
"This is truly helping me look professional online."
"You really make me look like I'm somebody..."
"Chris, we keep looking back at our photos almost everyday."
When I can hear those types of responses from you (overly-dramatic or not:)), then I know I've done my job.
Alright? Let's connect!


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I realize I'm way off topic here but this forum has been so helpful with my previous questions about IR circuit design that I figured I would come back and ask a couple more questions. Much of my problem comes from the fact that I don't 100% understand how transistors work although I'm learning a lot.
In the previous thread you helped me design a circuit based on the output portion of the TV-B-Gone in which I have an Arduino output pin connected to the base of a NPN driver transistor via 1K resistor and that in turn drives four PNP transistors and IR LEDs. I know this is opposite of the TV-B-Gone but that's immaterial right now.
I understand that this circuit is pushing way more current through the devices and their maximum ratings and we get away with it because we're only sending brief pulses. However one of my applications may be to control and IR control toy helicopter. While I've got some data on the protocols used to control the helicopter, I'm not really sure (until I buy one) how frequently the transmitter sends a signal to the toy. My guess is that it keeps sending the code continuously as quickly as it can. Even though it's a modulated 38 kHz signal and not all of the bits are on, my concern is that if this circuit would be in continuous use over several minutes. The datasheet talks about peak amperage with less than 1% duty cycle and we are way over 1%.
To simplify things let's assume we have a single transistor driving a single IR LED and the base voltage is enough to keep the transistor fully saturated. We're also working on a 5 V system. My datasheet says that the maximum continuous collector current is 600 mA. If I'm applying my Ohm's law properly that tells me I need at least 8.333 ohms of load to keep the current at or under 600 mA. Is that correct?
Putting IR LED between the collector and +5V by itself I presume has pretty much zero resistance. Therefore to keep the transistor from overheating/blowing up etc. I would need some sort of a current limiting resistor in line with that to keep the transistor current under specification. Is that correct?
Given that the continuous current rating of the IR LED is 100 mA that means I would need an even bigger resistor than 8.33 ohms. Again assuming I understand Ohm's law that means at least a 50 ohm resistor given 5 V supply and a 100 mA maximum rating. Is that correct?
I'm pretty confident that I understand everything I described above. What I don't understand is in the TV-B-Gone circuit or in my NPN/PNP swapped version it looks to me as though when everything is switched on you basically have a dead short running through the LED and the driving transistor. Is there internal resistance in a fully saturated transistor that limits its current? Is there internal resistance in a switched on LED that limits the current? Or are you merely relying on the limits of your power supply to deliver current? If there is some sort of inherent resistance when these devices are switched on, where do I find that in a datasheet?


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I think I found out about the sequel to Insidious through my reading. I follow several of the entertainment trade media outlets to stay abreast of upcoming movie releases, development deals and other assorted cinematic stuff. (It turns out, I'm a nerd when it comes to writing AND movies.) With that said, the moment I read about the sequel, I was instantly elated.
The first Insidious film really made an impression on me. I enjoyed it far more than I thought I was going to. As a matter of fact, I told my Facebook friends (and anyone else that cared to listen) that Insidious was the first movie to really scare me since Session 9, which came out in 2001. Coming from me, that's a big compliment because I love Session 9—hard. Whenever I watch that movie, for several days after viewing, the evil voice from the film will pop into my mind and scare the beejesus out of me.
Insidious managed to frighten me on the same level as Session 9. Essentially, It did its job as a scary movie—it terrified me. Because of this, I was sure that Insidious: Chapter 2 would do the same, especially considering that the entire cast came back for the sequel and the movie was a literal continuation of the storyline from the first film.
I went out to see Insidious: Chapter 2 on opening night. It was Friday the 13th and autumn was in the air, as was the Halloween theme music. The timing couldn't be more perfect, I thought, as Cristoph and I headed out to our local theater. We live in a college town so there were a lot of kids at the movies that night. There were so many in fact, that it was as loud as a cafeteria. Once we were let into our theater we knew we were embedded within a lively group. Unfortunately, they were so lively they couldn't bring themselves to STFU for more than 20 minutes at a time.
There was so much talking to the screen, talking to one another and shushing, that it was difficult to get lost in the ambiance conjured within the film. It was so loud in there that eventually I just gave up and tried to hear as much of the dialogue as possible. Needless to say, both my husband and I left the theater unsatisfied with the experience.
Once outside, Cristoph asked me if I knew what grade I would be assigning the film. I told him I wasn't sure yet. Then I started to think about what I'd just seen. I tried to remember the bits of the movie that were of particular interest, but I was having trouble. I figured I should just focus on trying to recall the mood that the movie was attempting to establish. That was when it hit me. It was so distractingly loud during the movie that I'd never gotten the chance to fully immerse myself in the story.
The kids were great and even funny sometimes, but dang man... That was a lot of noise and I'm a loud individual, so that should say something about the intensity of the situation. On the plus side, I managed to keep my trap shut and not tell everyone to go straight to hell for fucking up the movie going experience. I did shush loudly a couple of times, but that was all. I'm attempting to be less dickish in general and boy did this experience test my boundaries.
Anyhoo, since watching a movie at Animal House isn't the best way to set up the production of a well-informed movie review, I decided I needed to watch it again. I called up my BFF and we headed out to watch Chapter 2, this time in the suburbs. As expected, the movie going experience was much quieter there.
Upon exiting the theater the second time, I knew exactly what grade Insidious: Chapter 2 would be getting from me. I must admit, I enjoyed the film much more during the second viewing. I heard all the lines and was able to follow the plot. There were some good scares and rather creepy scenes, but overall I found the film lacking. I couldn't, however, pinpoint why at the time.
Fortunately, I'm ready now.
We first meet up with Josh Lambert (Patrick Wilson), in the past. It's 1986 and he's just a kid. His mother Lorraine (Barbara Hershey) has called in a medium named Carl (Steve Coulter) to find out what is terrorizing her son. Carl then calls on his friend Elise (Lin Shaye) to help him.
Elise shows up at Lorraine's house and hypnotizes Josh to discover that he's being stalked by an evil entity, which hopes to slip into Josh's body while he's out exploring other dimensions in his sleep or astral projecting. Elise quickly decides it's best to suppress Josh's special abilities while she has him under hypnosis. She knows that the nefarious entity stalking Josh is powerful and cunning. She also knows she must stop it now before it gets any closer to the world of the living.
Fast forward twenty five years and Josh's wife, Renai (Rose Byrne) is being interviewed by a cop about Elise's death. It seems the cop thinks Josh played some part in Elise's demise and he also thinks that Renai just might agree with him.
Insidious: Chapter 2 is the story of Josh and his family's last stand against an all-consuming evil that threatens to destroy them. Chapter 2 chronicles the suspicion of Josh's role in Elaine Rainier's death. Renai doesn't want to suspect her husband, but she's just been through supernatural hell and wants to ensure her family's safety at all costs. Lorraine, Josh's mother, knows there is trouble lurking in the shadows and calls upon her old paranormal friends for help once more. Together they fight the darkness that attempts to devour their souls.
I'll start off by saying that Patrick Wilson is one creepy motherfucker when he wants to be. He gave me the heebeejeebees the moment he popped up on screen. Wilson brings us a dubious hero in Josh Lambert. Josh has saved his family once from destruction, but what has become of him in the process? Wilson executes a delicate degree of animosity and exasperation throughout most of his performance and does so skillfully. I'm not gonna lie, it was a little scary to watch him unhinge.
Rose Byrne is the gentle force that grounds this film. As Renai Lambert, she's worn ragged with concern and just wants to free herself of the evil forces that haunt her family. Byrne has an exquisitely expressive face and she radiated an unease and stress that I imagine I would experience if I ever had to go through something paranormal of that magnitude.
Barbara Hershey is great as Lorraine Lambert. The standouts from the supporting cast, however, are Leigh Whannell and Angus Sampson as Specs and Tucker, respectively. They worked with Elise before her passing and they are again the comic relief in this franchise. Both performances worked to balance out the tension created through the story.
The acting was pretty good, the story a departure from the usual—intriguing on multiple levels, but still something didn't sit right with me. It took a while to figure out what bothered me about the movie and I'm not sure what tripped my epiphany this time. I just know that it happened. In replaying some of the scarier scenes of the movie in my head, I realized that some of the smaller details were what was throwing me off.
Back when the first Insidious came out and I was raving about it, one of my good friends commented that she thought the makeup in the movie left a lot to be desired. I disagreed somewhat at the time. She thought the makeup seemed a bit too basic and somewhat cartoonish. I could see where she was coming from, but I thought the makeup appropriate and even chilling.
I can't say the same about the makeup in the sequel. All the dead people were this common shade of Dead Guy Grey and I know that should appeal to someone like me, but it just seemed too standard—obvious and boring, visually. I would have liked to see semitransparent ghosts or something along those lines. Maybe if the faces were somehow unnaturally distorted or more visually disturbing. I'm not sure what the appropriate remedy would be; I just know I didn't like the presentation of the phantoms in this film.
The other element that seemed overly standardized was the presentation of the paranormal voices throughout the film. I realize I'm being nit picky with this, but the small stuff is what reverberates and makes the fear linger for me. These small details are vital to intensifying the overall fear factor and the sinister ghostly voices were more hokey than eerie. Instead of going with the standard cinematic expression of ghosts and ghouls James Wan (Director) should have ventured outside of this comfort zone. The story was fresh and so too should have been the imagery.
Overall this wasn't too bad. If you have a chance to get out there and see it in the theater, why not? Halloween is around the corner and we might as well start building that creepy anticipation now. People been celebrating the impending arrival of Christmas since June so I think we can go full steam with the Halloween thing, starting now. Have at it and check this one out. You'll like it if you like being scared.
Insidious: Chapter 2 (2013) - B-
B- = If you're already out and looking for a good movie time, watch this at your local theater. I'm not telling you to go out of your way for a viewing. I guess you could maybe stream this instead if that would be easier. Either way, it's decent times and you won't be mad that I encouraged you to sit through it.


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I came across this video made by SoulPancake and I knew I had to share it.
It is inspiring and so true. I hope you all get something out of it, just like I did.
And maybe if we all pass it on we can make the world a happier place.


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Hot Fudge Sundae Cupcakes
Super Cool Idea for Hot Fudge Sunday Cupcakes
Here is a video tutorial that shows you how to make a hot fudge Sunday inspired cupcake. Very cool:)
✿ Please subscribe! http://goo.gl/t5Kqdc
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Subscribe to my beauty/lifestyle channel: http://goo.gl/PQnCqG
✿ Hey friends! I found this cool cupcake idea from the Cupcakes Special Edition from Better Homes and Garden Magazine. Give this recipe a try and send me pics on Instagram or Twitter! Follow me at @aprilathena7 both on Instagram and Twitter! 😀
✿ Helpful tools for making the cupcakes:
yellow stand mixer: http://goo.gl/luUQ15
mixing bowls: http://goo.gl/NgnYSk
measuring spoons & cups: http://goo.gl/GqYbbX
hand mixer: http://goo.gl/Fb8QBI
Better Homes & Garden inspired, but they used cake mix and I wanted to make it from scratch: http://www.bhg.com/recipe/cupcakes/hot-fudge-sundae-cupcakes/
✿ Chocolate Cupcake Recipe from BHG inside the magazine, separate from the sundae article:
1 cup all purpose flour
3/4 cup unsweetened cocoa powder
1 1/2 teaspoon baking powder
1/8 teaspoon baking soda
1/8 teaspoon salt
4 tablespoon softened butter
3/4 cup sugar
2 eggs
1 teaspoon vanilla extract
3/4 cup milk
Bake 350 degrees farenheit for 18 minutes
✿ Creamy White Frosting Recipe from BHG:
1 cup shortening
3 cups powdered sugar
1/4 cup milk
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hot fudge sundae cupcakes, cupcakes, baking cupcakes
This video is not sponsored. We include affiliate links.
email: management(at)aa7media.com
Source: Hot Fudge Sundae Cupcakes – YouTube


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Lt. Maurice Splaine has been named to replace Police Chief Joe Rebello, whose last day on the job was Friday.
Kingston has a new police chief with the appointment of Lt. Maurice Splaine.
The 3-1 vote on Jan. 22 followed the recommendation of Police Chief Joe Rebello, whose last day on the job was Friday.
Splaine will serve as interim chief until he signs a contract with the town.
"I'm pleased, honored and privileged and look forward to the challenges of the job," he said.
Rebello said Splaine excels at the administration of the department and would be the best fit as chief.
"He has been my right hand for eight years, he has come along as far as the administration of the department, and he knows every facet of the department, every nut and bolt on the generator to every nuance in the labor contracts," he said.
Selectman Sandy MacFarlane voted for Detective Sgt. Robert Wells as chief.
The other candidates were Sgt. James Sauer and Lt. Tom Kelley.
In his interview, Splaine said he would recommend the hiring of at least two more officers but understands budget concerns.
Splaine, a former DARE officer for the department, said he cannot say a school resource officer would have prevented the tragedy in Newtown, Conn., but supports bringing back the position.
"I think it's vital," he said. "That would probably be the first position I would like to see reinstated, is the school resource officer, especially with what took place in Connecticut."
Follow Kathryn Gallerani on Twitter, @kgallreporter. email@example.com


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Bespoke Cycle Tours
Viva Velo was set up to provide something different from the run of the mill – but at a reasonable price. Because we are small, we believe we can offer special bespoke cycle tours without blowing your bank balance. What's the cycling trip you and your friends have always dreamed of doing? Are you looking for something special for a celebration? Or just for something a bit different that will suit the specific needs of your group? Give us your budget and we will do our best to provide you with the ideal trip, tailor-made to the individual needs of your group. Bespoke cycle tours are our raison d'être - so give us a call or drop us an email and find out what we can do for you.
For more information contact us by clicking the button or filling in the contact form below.
"A brilliant week with Dyll and all the team at Viva Velo. They were flexible, adaptable to our needs and focussed on what we wanted instead of making you feel like a number as other organisations do. They happily accommodated one of our riders, giving her a ride leader for an entire day away from the bigger group -you just don't get that level of attention elsewhere. Nothing is too much trouble for these guys. I developed significantly as a rider thanks to all the ride leaders who took time to help each one of us improve." Andy Fonseca


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Derby, Oaks ticket prices going up at the gate
If you want to go to the Kentucky Derby or Oaks, get your tickets now: the walk-up price for standing-room only general admission is going up to $50 for the Derby and $30 for the Oaks. But advance tickets are $40 and $25, respectively, at the on-track box office at Churchill Downs, at Gate 1, beginning Wednesday.
Some tickets also are available, through Friday, for limited seating in Section 125, which includes food in the Infield Club, for either the Oaks or the Derby. For more information and prices, go to ChurchillDowns.com/tickets.
For its spring meet opener on April 28, Churchill Downs is bringing back "Opening Night," the track's popular night-racing party that drew record crowds last year.


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To adopt, please submit the application at
Application Form or contact us at
Contact Us.
Meeting the dog can be arranged either in Denver or at the ranch (about 80-90 mi from Denver).
The dog can always be RETURNED to the rescue if it is not the right match (with full refind if returned within first 10 days). You have to be 21 years old or older.
Zeidi was saved by RUFF from a crack house. Thankfully, she really bonded with her caregiver Deidre. The closet in Deidre's room
is still her safe place, but now she comes out from there more and more, wags her tail and plays with the other dogs.
Lately she even allows us to pet her a little.
Peppie - someone tried to sell her as a rotweiller puppy and chopped off her tail.
She has never trusted people ever since and used to bite and growl at everyone who approached.
She still doesn't want to be touched,
but little by little her trust is coming back. She was saved by ECC.
Contact us »
NOTE: If the dog is unaltered at adoption time, the rescue obligates the adopter to have the dog spayed/neutered
within 1 month from the date of adoption and requests a $50 deposit which is returned to the owner
after the dog is spayed/neutered.
© 2019 - All rights reserved by San Nicola Dog Rescue


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Chillout Lounge ELASTiK20 April 2014
Chillout Lounge ELASTiK
TEAM MAGNETRiXX | 18 April 2014 | 1.03 GB
Ueberschalls Chillout Lounge offers ideal music for the relaxed moments. Calm, electronic sounds meet jazzy solos. Chillout Lounge brings all necessary material for Chillout, Downtempo and Easy Listening. If you are working in the field of music production, jingles, movie scores or any other multimedia project, this library will always be your source of inspiration.
The library contains 629 loops and samples, separated in ten Construction Kits. Each kit includes an intro, outro as well as an A and B-Part. Additionally each kit has an "Addon Folder" with suiting material that can be freely combined with your production. The 1.8 GB contains diverse drumloops, synth licks, pads, piano loops, guitar licks, SFX sounds, synth bass loops and percussion samples. Each drumloops is available in its different layers, including snares, hihats, claps, cymbals, bassdrums and percussion. The whole library combines Chillout and Lounge music with Nu Jazz and Ambient. The tempo of the kits varies between 62 and 105 BPM and the loops have a length of four to eight bars.
Genre: Chillout, Downtempo, Lounge
Elastik soundbank for
1.8 GB, 10 Construction Kits
629 Chillout Loops & Samples
INFO: http://redi.se/ea3
Chillout Lounge ELASTiK
http://beelink.in/14229/Chillout-Lounge-ELASTiK.htmlPrev. Post ► « Terror Bass WAV REX MASSIVE
Next Post ► Explosive EDM Arsenal WAV Sylenth1 and Massive Presets »
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Chargers General Manager A.J. Smith will not be making any bold proclamations about his team winning the Super Bowl. Or even the division.
Smith told U-T San Diego that after the Broncos won the AFC West last year and signed Peyton Manning this year, they deserve to be the favorites.
"As far as the division race is concerned, I know this, it will be very difficult to win the West," Smith said. "The Broncos are defending champs, and they added Peyton Manning. The Raiders and the Chiefs are much better. The Broncos are led by one of the greatest quarterbacks in NFL history. I just hope the Broncos don't run away with the division and leave the rest of us behind in the dust."
There may have been some sarcasm in Smith's voice when he said that, and he also said, regarding the Broncos' status as the division favorites, "I could care less about predictions."
Ultimately, Smith doesn't really think the Broncos are going to run away with the division. He thinks the AFC West will be close, with the Chargers remaining in contention to the end, just like last year.
"I hope it's a tight, competitive race to the finish line for all of us," Smith said. "That way, whoever comes out on top in the West will be primed for their playoff run. May the best team win, and I hope it's us."


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Since Ask, Listen, Learn began in 2003, underage drinking rates are down. Why? Because conversations among parents and educators with their middle schoolers are up.
Talking to Tweens & Teens About Alcohol
Ask, Listen, Learn: Kids and Alcohol Don't Mix is the most widely-distributed program of its kind. Recognizing over a decade of success, the program has innovative, science-based digital resources for teachers, school counselors, nurses and other educators to teach kids about what the brain does, what alcohol does to it, and what THAT does to you. The program continues to reach parents to help kids say YES to a healthy lifestyle and NO to underage drinking.
The new seven-part animation series aligns with National Health Education Standards, Common Core State Standards, and Next Generation Science Standards, ensuring the tools connect with curriculum teachers are already using. This alignment also ensures the resources can be used in multiple classroom settings, such as science and health classes. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) reviewed the program content and found it to be consistent with currently available science. These tools also support school counselors' and school nurses' efforts to help students make healthy decisions.
In addition to the animated videos and lesson plans, the new content includes interactive classroom activities, vocabulary exercises, comprehension questions, a facilitator's guide, and a sample letter to parents. All materials are free and ready to download through AskListenLearn.org—creating a one-stop-shop for all resources.
The program also has a wealth of materials for looking for parents looking for ways to start conversations about underage drinking with their kids.
Keeping with our tradition of researching and evaluating our programs, we commissioned an independent, external study on the efficacy of the new content. Researchers analyzed pre- and post- surveys from over 1,700 students in 70 schools across the country.
Here's what we learned:
- Ask, Listen, Learn empowers kids to make smart decisions in the future. 86 percent of students agreed that "this class has given me enough information to help me make good decisions in high school about drinking."
- Ask, Listen, Learn increases conversations between kids and adults. Results how a strong and consistent increase in communications between students and adult family members as a result of the curriculum.
- Students gain critical knowledge on how alcohol affects the developing brain through Ask, Listen, Learn lessons. Seventy-four percent of students believe they could effectively explain to a friend how drinking alcohol affects the brain.


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One of the cool things about Escape Rooms is that they are cooperative. This makes it a great choice for parties, like bachelor or bachelorette parties as well as team building events. Here at Enigma HQ, we do have another option, which is to turn it into a "race-room", where 2 teams compete against each other for the fastest time. Both teams enter their respective rooms at the same time and see which team finishes first.
This is a good option for large groups (over 8 or 9 people.) Most escape rooms aren't built for groups over this number of people even if they accept bookings for more. It's hard to have enough stuff for 10 or more people to have all at the same time.
A few tips for large groups:
- Do your drinking (or other inebriation) AFTER the escape room. Escape Rooms are fairly mental activities and while being in another state can be fun, it makes it a lot harder to do the escape room and honestly, makes it less fun as well.
- Consider a driver. It's more fun to all arrive at the same time. It's annoying for the party to have everyone ready to play except for a late arrival. Having everyone arrive at the Escape Room and leave together is a much better option. You get to discuss the puzzles and experiences afterward with the group while fresh in your mind. Consider using a service like Party Bus San Diego if you've got a big group.
- Make sure everyone knows what the activity is. The Lazarus Crystal isn't a particularly scary Escape Room but it has a slightly supernatural theme as well as involving a magic ritual. If you have someone in your group who HATES Harry Potter then maybe this isn't for them. Some people just find it unsettling to be doing something new or different. If your Escape Room of choice locks you in (or locks you up!) then make sure the group knows that beforehand.
- Keep it fun. Sometimes in Escape Room races, the teams get a little too competitive and the losing team feels bad that they got beat. While playful competition and teasing is great, make sure not to take it too far, unless your group really enjoys that sort of thing.
Brian Hacker has hosted more bachelor/ette parties than he has been to. He first started as a professional Magic player and went on to become a professional poker player and game designer. In an effort to understand obscure technologies and lose what remaining free time he had, he opened Enigma HQ!


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It's been one of the top places to be on a Friday and Saturday night for Wakey folk for years - and these photos prove it.
Click the above link for a trip down Flares' memory lane
We've dug out a stack of photos taken by our photographer who joined you all for a night out, Flares style' in 2005.
Were you there? Did we snap a picture of you and your mates? Take a look!
And let us know where else you partied in Wakefield and we'll see if we have the photos!


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The daughter of a wealthy dress manufacturer, she was born Frances Deitsch in New York City on October 21 1927. She attended private schools, then Temple University, Philadelphia, and the Fashion Institute of Technology in New York. Rebellious and vivacious, she began working in the fashion industry and soon became a figure on the Greenwich Village "Beat" scene.
In 1950 she married Jay Landesman, a bohemian who, in the course of a lifelong quest for a stardom that ultimately proved elusive, had already taken "tea with Bette Davis, cocktails with Bessie Smith and LSD with Timothy Leary"; he had also founded a short-lived avant-garde magazine called Neurotica, which purported to explore the "inner darkness" troubling modern America, but was mainly an excuse to write about sex.
In the early 1950s the Landesmans became known for their "open house" parties in Greenwich Village featuring "the most beautiful and neurotic people in the world". When Jay made plain early on that he did not want monogamy, Fran was delighted: "It meant I could have lovers too."
Subsequently the couple moved to St Louis, where Landesman and his brother opened the Crystal Palace, giving Woody Allen, Lenny Bruce and Barbra Streisand their first breaks in cabaret.
In 1959 the Landesmans collaborated on The Nervous Set, an affectionate satire on the Beat generation based on an unpublished autobiographical novel by Jay and featuring music by Tony Wolf and lyrics by Fran. First staged in St Louis, it played to packed houses before transferring to Broadway, where it bombed — although the songs Spring Can Really Hang You Up The Most (Fran's take on TS Eliot's "April is the cruellest month ...") and Ballad of the Sad Young Men became jazz standards recorded by the likes of Ella Fitzgerald, Bette Midler, Sarah Vaughan and Shirley Bassey.
In 1962 their lack of success in New York drove Jay and Fran (with their two young sons, Cosmo and Miles) to London, where Fran got a singing slot on a BBC programme. "Baby, this could be the start of something very big," said Jay; but the show was taken off the air within weeks. Jay fared little better. When he failed to raise a laugh during a 10-minute stand-up comedy routine for Peter Cook, he excused himself by saying: "Peter, this is subliminal humour: I'm trying to take the laughter out of comedy!"
When further efforts to find stardom met with an avalanche of rejection slips, the Landesmans threw themselves into what Jay called "creative living" — a hippy lifestyle which included unrestrained indulgence in extramarital sex. In Starstruck (2008), his memoir of his parents, the journalist Cosmo Landesman recalled the hideous embarrassment they caused him by canoodling with their various lovers in front of his school friends and turning up at parents' day looking "like two hippies who had failed the audition for Hair".
Their lifestyles soon earned them some of the fame they craved. In September 1964 The Sunday Times carried a profile of "a very way-out Salinger family just arrived in London", and during the 1970s they confessed all about their unorthodox marital arrangements (to Cosmo's mortification) to a journalist from The Observer. Both gave frequent interviews, and in 1984 Fran even appeared in a BBC documentary about open marriages called The Infernal Triangle.
Interviewed, aged 75, about her "ménage à trois", Fran was affronted by the implication that only one other person had been involved. "A 'ménage à trois' implies some kind of fidelity," she said. "It wasn't just one other person. It was a lot of people." Casual acquaintances "would usually become friends and come for supper and then we'd hang out," she explained. She never felt any jealousy, though she did not like it when her husband's companions were unattractive: "I used to think, 'What on earth is he doing with her?' " The cut-off point came when she was 60 and became a grandmother: "When you reach 60 — forget it. I just think it's unattractive after that."
Fran continued her career as a lyricist and later as a singer ("As a performer she moves like the Bride of Frankenstein; as a singer she sounds like Shirley Temple being strangled," observed Cosmo, a little unkindly). She wrote lyrics for Pat Smythe, Georgie Fame, Tom Springfield, Richard Rodney Bennett and Dudley Moore, and in the 1970s began writing and publishing poetry. Meanwhile, her husband Jay indulged in a series of mostly unsuccessful ventures, including putting on a musical about Dracula; staging a psychedelic drag show called Drag-It-On-Home-Baby; writing an unpublished surrealist novel called Bad Nipple; and managing the career of Doshin, Britain's worst kung-fu stripper.
Ironically, it was only really in the Nineties, when Cosmo Landesman married Julie Burchill, that the Landesmans found the celebrity they desired, albeit by proxy. In the mid-1990s Fran met the composer Simon Wallace and embarked on a collaboration which would last the rest of her life. The result was a late flowering of her career both as a lyricist and a performer. The pair provided songs for such shows as There's Something Irresistible in Down (1996), produced at the Young Vic; Forbidden Games (1997), staged in Bath, Edinburgh and Gdansk; and Queen of the Bohemian Dream (2007), produced in Washington, DC.
After a performance of Fran's saltily exuberant songs by Shepley Metcalfe in New York earlier this year, the New York Times critic observed that numbers such as It's Cool to Be Cool, Depravity and One Good Scandal "evoke the nocturnal adventures of a cranky, jazz-steeped, Beat Generation Dorothy Parker. In those days of hanging out in bars into the wee small hours, dragging home strangers whom you can't remember the next morning and generally acting up in the name of hip, dissipation was a competitive urban sport and Ms Landesman one of its champion chroniclers."
In 1996, however, the BBC received complaints after Fran Landesman appeared on Desert Island Discs and requested a supply of cannabis seeds as her luxury item.
In the last 10 years of her life Fran Landesman performed more frequently, both in Britain and America. Last year the South Bank Centre presented A Night Out with Fran Landesman at the Purcell Room, and in April this year she appeared in An Evening with Fran Landesman at the Leicester Square Theatre. Her last appearance was at Rada, two days before her death.
Fran Landesman's husband died in February, and she is survived by their two sons. Her feelings about her roller-coaster career were well expressed in the mock epitaph she composed for herself: "It was a good life, but it wasn't commercial."


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* Werbung *
Hi there,
I'm back with a mid month reminder for the Penny Black and More Challenge.
There our Theme is "Autumn Splendour".
Take a look at my card:
Also joining these challenges:
Penny Black Saturday Challenge 2018/10 Creative Friday Challenge # 216 Sweet Stamper Challenge # 2018/10/25 Steckenpferdchen Challenge 2018/10
I used a sweet stamp from Penny Black – 2252F Beware of Cat! and a stamp from Gummiapan. Dies are from Frantic Stamper and the spider web is from svg cut (i used my plotter).
Hope to see your creation at Penny Black and More Challenge!
Thanks from stopping by


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People & Places
June 9 - July 5, 2015
Opening Reception, Friday June 12 @ 6-9PM
with music from the Piedmont Regulators
Local oil painters Julia Harmon and Carroll Lassiter team up for People and Places, a show about memory. Using vintage amateur photography, Julia explores the emotional content carried in the image and how it ties to memory. Carroll finds memories rooted in the landscape of North Carolina, the fields, skies and roads traveled between Orange County and Edenton. This exhibition also includes, wood-turned pieces by Frank Penta.
Overtures: An Invitational
June 9 - August 9, 2015
Opening Reception, Friday June 12 @ 6-9PM
with music from the Piedmont Regulators
Overtures is an invitation to the public to view the work of seven extraordinary artists. The variety of materials and vision promises to be an experience you won't want to miss.
Abstract painters Anne Gregory, Paul Hrusovsky and Catherine Gregory are inspired by everything from global issues to the wonder of a childhood garden. Warren Hicks' photographs capture graphic black and white abstractions formed by shadows. Wood turner Ann Matrone releases stunning organic shapes from fallen trees. Sculptor Bill Moore's creations depict elements ranging from the sublime to the hilarious with exemplary skill and accomplished craft. Felt artist Sharron Parker uses dyed, unspun silk and wool to create abstractions using brilliant colors and textures.


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Pen and Ink.
18 in x 24 in
Text: By Reverend Dean Woodruff. From his paper 'The Myth of Apollo 11: The Effects of the Lunar Landing on the Mythic Dimension of Man.' and from the sermon he gave at St. Paul's Roman Catholic Church on July 20th 1969, the morning before the first moon landing.
"What happens today is an expression of man's ability – of man's self-determination. It is the molding of knowledge and theory; it is the channeling of human resources in solving problems; it is dreaming dreams and having visions; it is the concretizing of man's potential… Self-determination is our way of surviving in the mundane and through the spectacular; it is our existence – our fight with failure, out impetus toward achievement, our struggles with demonic forces; it is the grit of man. Self-fulfillment is "oughtness" and "giveness" – what we "ought to be" and "what it is given us to be". Fulfillment is the heart and soul of determination. Fulfillment is the meaning and purpose of self-determination.
When these two are put together perfectly we are what we are meant to be. This is what Nietzche developed in his idea of the "superman". It is not a new biological species but a new kind of man who realizes his capacity for self-transcendence and self-fulfillment. This is what Nietzsche meant when he spoke through Zarathustra: "bless the cup which is about to overflow, so that the water, golden flowing out of it, may carry everywhere the reflection of thy rapture. Lo! this cup is about to empty itself again, and Zarathustra will once more become a man.
One of the most ancient motifs found in mythology is called 'the magic flight'. Professor Eliade comments: "…It is found everywhere, and in the most archaic of cultural strata… the longing to break the ties that hold him in bondage to the earth is not a result of cosmic pressures or of economic insecurity – it is constitutive of man… Such a desire to free himself from his limitation, which he feels to be a kind of degradation… must be ranked among the specific marks of man." Apollo 11 will have the effect of saying to man that he can stand outside his world and view it as a whole. Science, as the achievement of man, has created a worldwide technical civilization and, as yet, has not given birth to any cultural symbols by which man can live. The Apollo event comes at a time when we need a symbol, and need to tap a myth that will graphically express the unending journey outward. Perhaps when those pioneers step on another planet and view the earth from a physically transcendent stance, we can sense its symbolism and feel anew breath of freedom from our current cultural claustrophobia and be awakened once again to the mythic dimension of man."


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Do you have a hankering for a half-slab slathered in thick, sticky-sweet barbecue sauce? Atlanta is a melting pot of cultures and just about every style of 'cue can be found here. Atlanta Eats presents our list of down and dirty neighborhood barbecue joints, from traditional to upgraded favorites, around the metro Atlanta area.
Chopped judge, Chef Aaron Sanchez, knows food. In a sauce-centric episode of The Best Thing I Ever Ate, he admits that he can't get enough of the sauce at Daddy D'z BBQ Joynt. Located about a mile east of 75/85 on Memorial Drive, Daddy D's has the motto "We ain't pretty, but we're good," and it more than lives up to expectations. From the outside it definitely ain't pretty, but once your plate arrives, you'll forget everything else until you run out of napkins.
On Dekalb Avenue, where Little Five Points meets Candler Park, Fox Bros BBQ has become a prominent brand of barbecue with many successes over the past few years. From getting bottles of their delicious BBQ sauce onto the shelves of local Kroger stores, to a feature on last season's Diners, Drive Ins and Dives with Guy Fieri. The founders of Fox Bros call their style of BBQ a mixture of "where we are from and where we are at" — Texas with a southern influence, and began selling their 'cue as a catering business, and then out of Smith's Olde Bar, before moving to their own home on Dekalb Avenue.
D.B.A Barbecue is a gem of a barbecue joint. Stuck behind the VaHi USPS Office on North Highland, it's one of those places that you kind of have to know it's there to know it's there. But it's absolutely worth taking the time to go to experience their spacious dining room (for a BBQ place), great hospitality, insanely delicious smoked wings and moonshine or bourbon cocktails.
One of the best places in Decatur to get barbecue — actually in the whole of Atlanta — is Community Q on Clairmont north of N. Decatur Road. Here you'll find all the plates you'd expect at a BBQ restaurant: St. Louis style ribs, brisket, half-chicken…the usual meaty suspects. But where Community Q blows away the competition is in the sides- Brunswick stew, baked beans, and arguably the best straight-up mac n cheese in the city.
A local favorite spot in Historic Roswell, Swallow at the Hollow has a well-earned reputation as one of the best BBQ restaurants outside the perimeter. In the summer, the rocking chair porch makes for a great spot to sit and listen to the live band inside most nights of the week. Don't forget to get their banana chocolate chip pudding for dessert!
While you'll find several bottles of traditional and Southern BBQ sauces on the tables at most 'cue joints, Heirloom Market BBQ in Cobb County (a bone's throw from the 75/285 interchange) includes KB sauce — Korean Barbecue. BBQ vaults are shipped in from Houston, Texas, and they use locally sourced hardwoods for the smoker. Keeping the footprint small, as many of the ingredients as possible are also sourced locally from Georgia farmers.
Following the footsteps of Fox Bros, Bone Lick BBQ started life as a Monday night special at P'Cheen in the Old Fourth Ward. After winning accolades all for his BBQ, Mike LaSage moved his operation to a full-time Q-spot in West Midtown in the summer of 2012, and continues to knock it out of the park. Did I say that Bone Lick has a "barcade" with classic 80s coin-op video games? And that it has skee ball lanes? No? Well I should have. My bad.
Over the years, Fat Matt's Rib Shack on Piedmont has become something of a local institution. On his show, The Layover, Anthony Bourdain admits that Fat Matt's doesn't serve "real" barbecue, but what it does is great utilitarian pork and beef smothered in sticky sauce. And he's right. He is, after all, Anthony Bourdain, so of course he's right.
Greater Good BBQ in Buckhead/Sandy Springs is one of those hole-in-the-wall spots that everyone seems to know about. There isn't a bad item on their entire menu, but we definitely have our favorites. Their specialty potato skins topped with pimento cheese, coleslaw, brisket and BBQ sauce are certainly one of a kind. We can't drive past GG without ordering a rack of ribs and a cup of mac n' cheese, so take that into consideration.
Twin Smokers BBQ may be new to the game of BBQ in Atlanta, but they show no signs of inexperience. In fact, there was so much research done before opening the restaurant, they decided to include key flavors of North Carolina, Kansas City and Memphis barbecue. There is something for everyone here, but make sure not to skip the double trouble bourbon milkshake, the brisket or the jalapeno mac n cheese.
A restaurant that has outlasted a decade in downtown Alpharetta, SmokeJack, is no easy feat. They attribute the success to using the freshest ingredients and making every item from scratch, but there is something about SmokeJack we can't get out of our minds. It may be an off-the-menu item, but we had their brisket sandwich topped with a heap of pimento cheese and homemade pickles at the Alpharetta food trucks and we've been craving another ever since.
Like many other slab-and-sauce spots, Hometown BBQ goes with the "converted house" look — and makes it work. The meat here is southern traditional with sauces on the side, and there's nothing you won't enjoy about the food — be warned, though: Hometown doesn't accept cards but there's an ATM in the restaurant.
Boasting that it has "the best butts in town," the Tipsy Pig operates out of a gas station in Lilburn. If you can get over that, stop in for some great 'cue.
The kings of "low and slow", Pig-N-Chik is known for incredible classic barbecue and a couple non-traditional menu items (i.e. smoked salmon, fried okra, hushpuppies…etc). The craziest concoction they offer? Redneck Nachos! Fries are loaded with Cheddar cheese, chunks of pork and barbecue sauce.
Dave Poe's BBQ serves award winning pit cooked BBQ in Marietta. It says so right there on the Web site. All the meats and sides you want at a barbecue place, and three sauces to drown your smoked meat in, but this place has something…unexpected. Redneck Lasagna: mac n cheese covered with Brunswick stew – why didn't anyone think of this before?
Off Peachtree Industrial at Jones Mill Road, JR's Log House celebrated 30 years in 2013. If you're hungry for ribs, JR's has ALL YOU CAN EAT St. Louis ribs, served all day (well, until 30 minutes before closing). And the price for gorging yourself on ribs the whole day? Less than $14.
Hungry for more barbecue inspiration? Check out barbecue spots around Atlanta here. Be sure to catch Atlanta Eats on Peachtree TV every Saturday at 7:30 p.m. and Sunday at 10:30 a.m.!
For more Barbecue restaurants, click here.


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|Displaying Lapwings (c) Bark
|Ringtail with missing primaries (c) Bark
|Whitefronts on Big Otmoor (c) Bark
|and earlier in the mist (c) Terry Sherlock
Despite misty starts both mornings it was possible to believe this weekend that winter is relaxing its grip and spring is not so far away.
The birds sense the difference too and there were Chaffinches, Greenfinches, Skylarks and Great Tits singing. Even more noticeable were the lapwings that have started calling, courting and displaying. Whether these are birds getting early pairing practice or breeding residents it is impossible to say, nonetheless it is very encouraging to see and enjoy. There is a slight flush now in the hedgerows and Bullfinches have started feeding on blackthorn buds in the car park field.
There are substantial numbers of Lapwings and Golden Plovers scattered over the main fields, when they flush it is possible to spot ten or so Dunlin flying with them. Amongst the birds causing them to flush were a male and ring-tailed Hen Harriers. The ringtail is missing at least one of its primaries from its left wing and is easily identifiable, it would be interesting to hear if there are any other ring-tailed birds present as there had been at least two in the earlier winter period. In addition a male Peregrine with an exceptionally white breast was hunting over big Otmoor on Saturday. There were also Sparrowhawks, a pair of Kestrels at Noke and several Common Buzzards and of course a procession of Red kites passing over the reserve. Barn Owls are hunting regularly over the reedbeds and have been seen frequently at both ends of the day.
Duck numbers remain high and included a party of fifteen Pintail flying together. There was also a single Shelduck on big Otmoor on Sunday.
The Bittern was not seen this weekend to the best of my knowledge, but was recorded on Friday morning from the first screen. With raised water levels on the southern reedbed it is likely that it can feed in deep cover.
There was a large congregation of Gulls loafing and feeding on the flooded fields at Noke. They were mostly Black headed Gulls but amongst them were twelve Lesser black backs, a Greater black back a Herring Gull and two Common Gulls. The latter being a new record for the year. The other addition to the yearlist was a Marsh Tit on the feeders, this brings us up to ninety species for the year.
We have seen very few different wader species so far this year and have yet to record even a Redshank. During the next couple of weeks we should have the Curlews arriving and after that other species will follow and with them the spring.


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Culver City Personal Injury Lawyer
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Culver City in Los Angeles County is home to Sony Pictures Entertainment, The NFL Network, National Public Radio West and Beats Audio. Since the 1920's it has been a center for motion picture and television production. Served by the highly-traveled 405 and 90 freeways, it's boarded by Venice, Ladera Heights, Westchester and Marina Del Rey. The population in Culver City is 39,406 and
The California Office of Traffic Safety (OTS) reported 298 injuries and fatalities as a result of auto accidents in Culver City in 2013. 39 of those injuries and fatalities were speed related, 33 involved bicyclists and 25 involved pedestrians. They also report there were 93 DUI arrests made that year. Recently Culver City filed a suit against the FA over the change in its flight paths at nearby LAX, due to the environmental effects of increased flyovers.
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With 1-800-THE-LAW2, you'll have a knowledgeable attorney who can work to get you compensation for personal injuries, work injuries, and vehicle-related injuries. Call us at 1-800-THE-LAW2, fill out the Free Consultation form to the right, or use the LIVE CHAT feature on the bottom right of the screen to discuss your case with a Culver City lawyer today.


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South Korea has dropped plans to resume whaling in its coastal waters amid a storm of international criticism, and will instead use non-lethal methods to conduct research into the mammals.
The country provoked anger when it announced plans at a meeting of the International Whaling Commission [IWC] in Panama in July to conduct "scientific" whale hunts similar to those carried out by Japan in the Antarctic every winter.
The decision to ditch the plans became official when the government failed to submit a formal proposal to the IWC by the 3 December deadline.
"After gathering opinions from various sides, the government is now in the process of finalising its plan to study whales through non-lethal techniques, like many other countries such as Australia do," the Korea Herald quoted a fisheries ministry official as saying.
The IWC's 1986 ban on commercial whaling allows member countries to hunt whales for scientific research, with the meat then sold on the open market.
Japan, which uses the loophole to kill hundreds of whales every year, is expected to send its whaling fleet to the southern ocean in the next few weeks.
South Korea initially said an increase in whale stocks in its coastal waters had prompted the decision to resume whaling. The fisheries ministry said rising whales numbers posed a threat to squid and fish stocks.
The ministry reportedly began to reconsider after criticism from anti-whaling nations and an online petition that attracted more than 1,000,000 protest emails in three weeks.
"The world does not support commercial whaling, even when it is disguised as scientific research," said Greenpeace International oceans campaigner John Frizell.
"The decision by South Korea to listen to its own people and the global community and abandon a whaling programme modelled on that of Japan is a huge win for the world's whales."
South Korean media said the fisheries ministry had come under fire from other ministries for announcing the plans without consulting them.
The International Fund for Animal Welfare welcomed the move and urged South Korea to reduce the number of whales that get entangled in fishing nets. Meat from the by-catch is sold in cities such as Ulsan, the home of the South Korean whaling industry.
"The government of Korea made the right call and should be commended for it," said Patrick Ramage, the director of the fund's global whale programme. "Whaling in the name of science is unnecessary, and killing whales for commercial purposes is a proven ethical, ecological and economic loser in the 21st century.
"We stand ready to support Korea in whatever appropriate way as it embarks on state-of-the-art, non-lethal whale research in Korean waters."


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You are here
Cytokinetics Announces Data From Phase 2 Clinical Study of Reldesemtiv in Patients With Spinal Muscular Atrophy to be Presented at the 2018 Annual Cure SMA Conference on June 16, 2018
SOUTH SAN FRANCISCO, Calif., June 08, 2018 (GLOBE NEWSWIRE) -- Cytokinetics, Incorporated (Nasdaq:CYTK) today announced that data from the Phase 2 clinical study of reldesemtiv in patients with spinal muscular atrophy (SMA) will be presented in an oral presentation at the 2018 Annual Cure SMA Conference in Dallas on June 16, 2018.
Date: Saturday, June 16, 2018
Location: Hilton Anatole Hotel, Imperial Ballroom
Session: Preclinical and Clinical Drug Development
Presentation Time: 10:40-11:00 AM CDT
Title: Update of CY 5021: A Phase 2 Clinical Trial of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator (FSTA), for the Potential Treatment of Spinal Muscular Atrophy
Speaker: John Day, M.D., Ph.D., Professor of Neurology and Pediatrics (Genetics), Stanford University Medical Center
About Cytokinetics
Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators as potential treatments for debilitating diseases in which muscle performance is compromised and/or declining. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to increase muscle function and contractility. Cytokinetics is collaborating with Amgen Inc. ("Amgen") to develop omecamtiv mecarbil, a novel cardiac muscle activator. Omecamtiv mecarbil is the subject of GALACTIC-HF, an international Phase 3 clinical trial in patients with heart failure. Amgen holds an exclusive worldwide license to develop and commercialize omecamtiv mecarbil with a sublicense held by Servier for commercialization in Europe and certain other countries. Cytokinetics is collaborating with Astellas Pharma Inc. ("Astellas") to develop reldesemtiv, a next-generation FSTA. Reldesemtiv has been granted orphan drug designation by the FDA for the potential treatment of spinal muscular atrophy. Reldesemtiv is the subject of three ongoing Phase 2 clinical trials enrolling patients with spinal muscular atrophy, chronic obstructive pulmonary disease and amyotrophic lateral sclerosis. Astellas is also conducting a Phase 1b clinical trial of reldesemtiv in elderly adults with limited mobility. Astellas holds an exclusive worldwide license to develop and commercialize reldesemtiv. Licenses held by Amgen and Astellas are subject to Cytokinetics' specified co-development and co-commercialization rights. Cytokinetics continues its 20-year history of innovation with three new muscle biology directed compounds advancing from research to development in 2018. For additional information about Cytokinetics, visit www.cytokinetics.com.
Forward-Looking Statements
This press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the "Act"). Cytokinetics disclaims any intent or obligation to update these forward-looking statements, and claims the protection of the Act's Safe Harbor for forward-looking statements. Examples of such statements include, but are not limited to, statements relating to Cytokinetics' and its partners' research and development activities, including the Phase 2 clinical study of reldesemtiv in patients with SMA; the design, results, significance and utility of preclinical study results; and the properties and potential benefits of Cytokinetics' drug candidates. Such statements are based on management's current expectations, but actual results may differ materially due to various risks and uncertainties, including, but not limited to, potential difficulties or delays in the development, testing, regulatory approvals for trial commencement, progression or product sale or manufacturing, or production of Cytokinetics' drug candidates that could slow or prevent clinical development or product approval; Astellas' decisions with respect to the design, initiation, conduct, timing and continuation of development activities for reldesemtiv; Cytokinetics may incur unanticipated research and development and other costs or be unable to obtain additional financing necessary to conduct development of its products; standards of care may change, rendering Cytokinetics' drug candidates obsolete; competitive products or alternative therapies may be developed by others for the treatment of indications Cytokinetics' drug candidates and potential drug candidates may target; and risks and uncertainties relating to the timing and receipt of payments from its partners, including milestones and royalties on future potential product sales under Cytokinetics' collaboration agreements with such partners. For further information regarding these and other risks related to Cytokinetics' business, investors should consult Cytokinetics' filings with the Securities and Exchange Commission.
Diane Weiser
Vice President, Corporate Communications, Investor Relations
(415) 290-3060


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MINERVA / Series I: Materials curates poetry PDFs that use a specific thread of 'material' running throughout 4 poems in some way.
Toby, [why] crucifixions:
Although we think of history as moving, as continuing, and as ourselves as bound up in its flow, it is my view that history has already ended; or, rather, that history's telos has been reached, and that what remains is an endless recapitulation, an after-echo of that moment of attainment, rather like the ripples in a lake moving outward from the point at which a stone hits the water – I refer to the crucifixion, and believe it to be the defining image of Man, which no other image can supercede, though our species thrives and spreads to every corner of the universe. Whatever we may hope, what we finally know is that each of us must come to terms with and fulfill the image of a man or woman hanging in agony, abandoned and alone.
Whether we can grasp the consolation that is offered as part of this dynamic of suffering and loss is a personal and private matter for each of us, but prior to that, and upon which that consolation and hope is contingent, there rises the image of the cross, the fundamental and perfect precept and representation of existence – imprinted in the smallest micro-organism, and looming between the very poles of the physical universe, from the beginning to the end.


text:
In a round-about way, I got two mentions in Publishers Weekly (an online magazine) last week. Fun! One of those is an announcement of The Contemps, the new joint author blog I mentioned in a previous update.
The second is that Freefall is listed in the Fall 2010 Children's announcements. (To read the listing, scroll down over halfway down the page to the S&S/Simon Pulse category. They seem to be in random order, but Freefall is definitely there if you look hard enough.)


text: Webdriver Torso sings us into this episode with Ross Moody. Ross is a man who knows how to chase down a good idea. His companies 55hi's and Madison Glass Co help pay the bills while he works design for his day job. Pretty impressive resume if you ask me. I talk to Ross about his humor, social media, his belief in the history of Typography, and how he came to creating his companies and with the idea of fathers on the mind, if he's thinking about becoming one himself.


text:
The trend report: Ladylike dressing
See Gallery
Lately, we've been taking special notice of stylish celebrities who have embraced the ladylike trend on the red carpet. Longer hemlines, elegant fabrics, and graceful silhouettes all suddenly feel quite right for the new fall season. Michelle Monaghan's lovely red Delpozo dress and Diane Kruger's flouncy black and white look are perfect examples of the ladylike look we're loving right now. If you're not headed for the red carpet, however, it's plenty easy to replicate the trend in the form of structured wool coats, top-handle bags, and pretty midi skirts. Click through the gallery to see our full report on the trend.


text:
WWII Survivor
Tucked behind and to the side of Denby High School is the Lyle Maxton Skinner Memorial Playfield. Stocked with newer equipment, this playground is attractive and services the neighborhood off Duchess and Morang on Detroit's eastside.
Lyle's courage
Lyle grew up on the west side of Michigan. Married to Jennie and living in Flint, he enlisted in the US Navy on June 15, 1937. During World War II he served aboard the Aircraft Carrier the USS Hornet. As a Watertender First Class, Lyle worked in the ship's engine room / boiler room. October 26, 1942 marked the battle of the Santa Cruz Islands located in the Pacific Ocean north the Solomon Islands. In this battle, the US military was playing a game of catch-up against numerically superior Japanese forces. The Japanese were heavily bombing ships in the area. During the attack, the USS Hornet was being violently shaken by bursting bombs and Skinner was ordered to abandon ship. Instead, Lyle entered an oil-filled elevator pit and rescued a trapped shipmate who would have died otherwise. The USS Hornet later sunk.
Lyle's courage and heroism earned him the honor and award of the Navy Cross. Unlike many war heroes, Lyle lived through this experience and was able to accept the medal personally. He returned to the west side of Michigan and died in the small village of Leroy, Michigan in 1984.
Copyright 2013. © Andrea Gallucci All rights reserved.


text: We appreciate your interest in EuroChrist Ministries. On our site you can learn more about who we are, see some pictures of things going on in the ministry, and learn about the progress on the Rembrandt Schenke, a former restaurant named "Stadt Bayreuth". Many thanks to all the people who have helped us with the finances or labor of our building renovation in the last years! Without your support, we would not be able to do what the Lord has laid upon our hearts. Feel free to check out some of the recent pictures of our progress.


text:
Zootopia is coming to Japan at the end of April and the toy stores are stocking up on goods.
The Police SUV is huge and barely fits in a regular Tomica box. In comparison the ZPD vehicle looks tiny. The van is smaller than a regular Tomica van and I wished it would have been a bit bigger, but that may be to keep it on scale with the SUV (haven't seen the movie yet).
If the launch is succesful TakaraTomy may release more cars from the movie. I certainly hope so since Zootopia seems to be filled with great car designs from J Mays.


text:
Orman calls for changes in credit scoring at Newsmaker
January 13, 2012 | By Heather Forsgren Weaver | firstname.lastname@example.com
Personal finance expert Suze Orman is on a mission to make it easier for people who make purchases using cash or debit cards to get a better credit score.
"You have people who are in credit-card debt who pay the minimum payment due at a 29 percent interest rate," Orman said.
Those people have higher credit scores than people who have no debt, but pay for their purchases using cash or debit cards, she said.
Orman appeared at a National Press Club Newsmaker Jan. 12 with PBS TV host Tavis Smiley and Princeton Professor Cornel West.
The centerpiece of Orman's crusade is the Suze Orman Approved Card, a prepaid debit card, which she unveiled Jan. 9.
Anonymous spending data from users will be sent to TransUnion to study whether this information can be used by FICO, a public company that uses analytics to score credit for financial institutions, to improve credit scores.
"Do you all get that we are all judged on this little three-digit score known as a FICO score," Orman said. "FICO scores determine the interest rates you pay on car loans, home mortgages, credit cards. They are also starting to determine if a landlord will rent to you, if an employer will hire you because they look at your credit report as well. It determines what your car insurance premiums are and on and on and on."
Following their appearance at the Club, Orman, Smiley and West were scheduled to appear on a live panel discussion on eradicating poverty at George Washington University being broadcast by C-Span.
Improving credit scores is a key way to help people out of poverty, Orman said.
The words poverty and poor were not mentioned during the three debates held during the 2008 presidential election campaign, Smiley said.
"We are not going to endure another race for the White House where the issues of the poor in this country go unaddressed," Smiley said.
Eradicating poverty is a "moral issue about what kind of nation we want to be," West said.
There is a general misconception about who is poor, Orman said. "The one thing that is fascinating about money is that you can't look at somebody and know any more are they rich or are they poor."
Orman no longer sees a middle class, she said. "The middle class has disappeared. There is a highway into poverty. There is not even a sidewalk out."


text:
In uae there are two types of mosquito
Anopheles (uh-noph-o-lease)
Adults of this genus are found primarily in temporary rain pools, swamps, and ponds. They feed readily on humans. Certain species of this genus serve as the primary vector of malaria.
Culex (cue-lex)
Species of this genus are found breeding in freshwater habitats such as pools, ditches, ponds, and even in effluents of sewage treatment plants. Species in this genus are considered to be of medical importance in that they have been proven to be the primary vector of St. Louis Encephalitis and also play an active role in the transmission of West Nile Virus. They are most active at dusk, but are known to be active daytime biters.
Life cycle
Adult mosquito female requires a blood meal in order to reproduction and laying egg. After taking blood meal mosquito search for a suitable place to put her eggs for beading such as standing water.
Male mosquito can live 10-20 days and female mosquito can live between 3-100 days depend on mosquito species and environment.
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