text:
The etiology of Behçet's disease (BD) is unknown, but widely considered an excessive T-cell mediated inflammatory response in a genetically susceptible host. Recent genome-wide association studies (GWAS) have shown limited number of novel loci-associations. The rarity and unequal distribution of the disease prevalence amongst different ethnic backgrounds have hampered the use of GWAS in cohorts of mixed ethnicity and sufficient sample size. However, novel statistical approaches have now enabled GWAS in admixed cohorts.
We ran a GWAS on 336 BD cases and 5,843 controls. The cases consisted of Western Europeans, Middle Eastern and Turkish individuals. Participants from the Generation R study, a multiethnic birth cohort in Rotterdam, The Netherlands were used as controls. All samples were genotyped and data was combined. Linear regression models were corrected for population stratification using Genomic Principal Components and Linear Mixed Modelling. Meta-analysis was performed on selected results previously published.
We identified SNPs associated at genome-wide significant level mapping to the 6p21.33 (HLA) region. In addition to this known signal two potential novel associations on chromosomes 6 and 18 were identified, yet with low minor allele frequencies. Extended meta-analysis reveal a GWS association with the IL12A variant rs17810546 on chromosome 3.
We demonstrate that new statistical techniques enable GWAS analyses in a limited sized cohort of mixed ethnicity. After implementation, we confirmed the central role of the HLA region in the disease and identified new regions of interest. Moreover, we validated the association of a variant in the IL2A gene by meta-analysis with previous work. These findings enhance our knowledge of genetic associations and BD, and provide further justification for pursuing collective initiatives in genetic studies given the low prevalence of this and other rare diseases.
Citation: Kappen JH, Medina-Gomez C, Hagen PMv, Stolk L, Estrada K, Rivadeneira F, et al. (2015) Genome-Wide Association Study in an Admixed Case Series Reveals IL12A as a New Candidate in Behçet Disease. PLoS ONE 10(3): e0119085. https://doi.org/10.1371/journal.pone.0119085
Academic Editor: Rodney John Scott, University of Newcastle, AUSTRALIA
Received: September 1, 2014; Accepted: January 4, 2015; Published: March 23, 2015
Copyright: © 2015 Kappen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Data Availability: Due to restrictions based on privacy regulations and informed consent of participants, phenotype and genotype data cannot be made freely available in a public repository. Data from this study can be obtained upon request. We have included this in the methods sections of the manuscript. Data of the Generation R Study can be obtained upon request. Requests should be directed towards Prof.dr. V. Jaddoe (email@example.com). As for the data collected exclusively for this effort, requests should be directed towards the corresponding author (email@example.com).
Funding: Financial support provided by; Vereniging Trustfonds Erasmus Universiteit Rotterdam, De Landelijke Stichting voor Blinden en Slechtzienden, Stichting Janivo, Stichting Mitialto, dr N. Nobel and Actelion made this study possible. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Behçet's disease (BD) is a systemic auto-inflammatory occlusive vasculitis presenting with oral and genital aphthous ulcers, skin lesions, ocular inflammation and a pathognomonic pathergy test [1–3]. Although the etiology of the disease is largely unknown, it is considered to be an excessive inflammatory response possibly triggered by an infectious antigen in a genetically susceptible host. Prevalence varies from 110–420 per 100,000 in the Middle East (Turkey) to about 2 per 100,000 in Western countries [3,4]. In patients of Turkish origin there is a positive family history in 12% of the cases with a sibling risk ratio between 11–52 [3,4]. The heritability of BD has been estimated to range between 20 to 60%, with the strongest genetic association embracing variants in HLA-B51, explaining about 20% of the disease heritability [3,4]. The combination of epidemiological and genetic data suggest causal involvement of both genetic and environmental factors [5].
Over the years, numerous single nucleotide polymorphisms (SNPs) have been found associated with BD [6–9]. In 2010 the first genome-wide association study (GWAS) in BD cohorts of Turkish and Japanese origin demonstrated association of various variants in the known HLA-B51 domain, and two new association signals, mapping to the interleukin-10 (IL10), and the IL-23 receptor–IL-12 receptor Beta2 (IL23R–IL12RB2) locus [10,11]. These associations later have been confirmed in an Iranian cohort [12]. Yet another study in Algerian individuals only replicated the associations from the IL10 variants [13]. GWAS in Chinese and Korean individuals reported associations of SNPs mapping to two other loci, with regions containing the signal transducer and activator of transcription 4 (STAT4) and GTPase of immune associated protein GIMAP genes, respectively. Polymorphisms in IL10 and IL23R–IL12RB2 were not found to be significantly associated with BD in neither of those studies (14,15). More recently, associations with CCR1, STAT4 and KLRC4 were identified by means of imputation and GWAS meta-analysis [14]. This study also identified the IL12A region as suggestively associated with BD, but genome wide significance (GWS) was not reached. Discrepant association results, as those observed for variants mapping to the GIMAP locus, might be explained by the different ethnic origin of the cohorts studied [15,16]. Therefore, studying cohorts of diverse ethnic background may be useful to understand the origin of these differences. Moreover, the inclusion of multiple ethnicities results in larger datasets (representing higher power) crucial for these analyses given the typically small effects of common genetic variants discovered by the GWAS approach [17]. Nonetheless, GWAS results can be confounded by ancestry differences between cases and controls, potentially leading to spurious associations. This challenge in multi-ethnic studies has so far been approached by methods that take into account confounding by genetic ancestry, such as correction for Genomic Principal Components (GPC) [18]. More recently, linear mixed models (LMM) have been introduced as a reliable method to correct not only for ancestry differences, but also for family structure and/or cryptic relationships [19].
We have therefore set up a multi-center GWAS including BD patients of both Middle Eastern and Western background. We demonstrate that by means of novel statistic approaches it is feasible to run a GWAS in a small multiethnic cohort and use these results for meta-analysis.
Materials and Methods
Study populations
A total of 369 unrelated BD patients from 18 different geographic origins were included in our study (Table 1). The age range was 18 to 73 years (mean 47 years). All patients fulfilled the International Study Group (ISG) criteria of BD diagnoses [20]. No exclusion criteria were applied.
As controls, 87 Syrian healthy volunteers (22–73 years, mean 51 years) and 5,756 participants from the Generation R study, a multi-ethnic birth cohort in Rotterdam (4–9 years, mean 6 years), The Netherlands, were used [21].
Replication was pursued in a cohort of 82 BD patients who met the ISG criteria, and 98 ethnically matched controls in Western European, collected from Birmingham and Midland Eye Centre, Birmingham, UK.
The ethics committees of the involved centers (Erasmus MC (METC), Ethical Committe at Çukurova University and Sandwell and West Birmingham Hospitals Trust Ethics Committee) approved the study, and written informed consent was obtained from all participants.
Genome wide genotyping
Genotyping of cases and controls (including the Generation R Study) was performed using the Illumina HumanHap 610K and/or 660 K arrays, following manufacturers protocols. Quality Control (QC) was performed individually for each set following a standard protocol to exclude samples and SNPs with low quality genotyping. Markers with minor allele frequency (MAF) ≤ 1%, missing genotypes ≥5% or which failed an exact test of Hardy-Weinberg equilibrium proportions in the controls (P<1x10–7) were excluded from the datasets. Samples with gender discrepancy, excess of heterozygosity, duplicates or samples with relatedness or other inconsistencies were also removed. In a subsequent stage, we extracted SNPs common to both platforms which passed individual QC and then applied the QC protocol for the combined dataset.
Phenotype-Genotype Analyses
To characterize the extent to which common genetic variants play a role in BD susceptibility, we applied a recently proposed approach for estimating heritability based on genome-wide sharing between distantly related individuals, as implemented in the GCTA software in combination with the determination of ancestry-aware kinship coefficients by REAP software [22,23]. No pairs exceeded the standard cutoff coefficient of 0.025 for genetic relatedness, confirming that no two individuals in the analysis were closer than third degree cousins. Relatedness coefficients calculated from REAP were used in the relatedness matrix before implementing GCTA. A disease prevalence of 0.42% was used in the modelling [3,4].
Genome-wide association analysis.
Association between BD susceptibility and 553.224 genome-wide SNPs was carried out using a regression framework adjusting for population stratification. GWS threshold for the association was established at p<5×10-8. Two different strategies were followed to adjust for population sub-structure in the data.
Genomic Principal Components.
In the first approach, 20 GPC were obtained for all pairs of individuals in the combined dataset based on the similarities of individual genotypic profiles for 37,060 independent autosomal SNPs contained in the HapMap Phase II release 22 build 36 [24] using Multi-Dimensional Scaling (MDS) as implemented in PLINK (http://pngu.mgh.harvard.edu/purcell/plink/). Afterwards, we performed logistic regression adjusting for those 20 GPC.
Linear Mixed models.
In the second approach we used LMM in order to account for possible population structure in the association analysis. This methodology estimates the level of relatedness even between independent individuals using the genotyped markers. By modeling the dissimilarity between genotypes of the subjects, it is able to correct the association results for stratification. This approach is implemented in the publicly available EMMA eXpedited (EMMAX) software [25]. Since the effect sizes reported by EMMAX are based on Mantel–Haenszel statistics, the odd ratios for associations of the significant SNPs were estimated from the regular logistic regression models performed in PLINK.
Replication analysis
Four SNPs: rs8187722, rs439033, rs11969661 and rs17087141 were genotyped using TaqMan assays designed by Applied Biosystems, Warrington, UK in 82 BD patients and 98 control samples. In short, PCR was performed in 384-well plates with a 10 μl total reaction volume containing 20 pg/ml DNA (samples) or water (controls) and 2x LC-480 probe master (Roche, West Sussex UK) followed by endpoint genotyping analysis using the LC-480 system (Roche, West Sussex UK). Genotypes were determined as either homozygous (e.g. AA or GG) or heterozygous (e.g. AG) according to the presence or absence of fluorescence for each genotype.
An overview of the ethnicity of the included BD cases is presented in Table 1; all controls were collected in St John's Ophthalmic Hospital, Jerusalem and had Arab ancestry. In order to gain power and match all remaining ethnicities, this dataset was combined with the genotyped samples from the multiethnic Generation R Study.
Genome wide Genotyping
Genotyping was performed in 456 samples (369 cases and 87 controls) collected from the different participating hospitals (Erasmus MC at Rotterdam, The Netherlands, University Hospital of Cukurova, Turkey, St John's Ophthalmic Hospital, Jerusalem, Israel and by St Thomas' Hospital, London, UK). After quality control, 553,224 genotyped SNPs in 423 of these samples remained. We excluded 33 patients (including 1 control) because of low Illumina call rate (< 97.5%) and one more individual was excluded for gender mismatch. After QC of this combined dataset, 336 cases and 5843 controls were available for analysis.
Phenotype Genotype Analyses
The heritability estimate, based on the 505,454 genotyped SNPs and 4,855 unrelated individuals (296 cases) was 32.0% (95%CI 21.0–44.0%;P = 5.5E-17). Thus a considerable percent of the BD risk is explained by the additive effect of the common SNPs analyzed.
Genomic Principal Components.
The representation of the first GPC for the combined dataset projected together with the three reference panels of the International HapMap Project Phase II known as YRI, CEU and CHB/JPT representing populations of African, European and Asian background respectively [27] is shown in Fig. 1. As shown by the overlapping distribution across the four first GPC, BD cases (represented in black) are well matched by genetic ancestry to controls (represented in yellow Syrian volunteers and grey for Generation R participants).
Two-dimensional scatterplots from multidimensional scaling analyses of the Generation R Study and Behçet collected data together with the three initial Panels form the HapMap Project. Each dot represents an individual in the dataset. Color codes: Grey = Generation R, Black = Behcet Cases, Yellow = Jordan controls. Blue = CEU, Red = YRB, Green = JPT.
Genome wide association analysis.
Association analyses were performed for 505,454 SNPs. As expected in such structured population, results from analysis without any type of stratification adjustment, showed association through the whole genome and a Genomic Inflation Factor (λ) of 5.25 (S1 Fig.). After GPC correction, the association analysis showed minimal inflation of the test statistics with a λ of 1.035 (Fig. 2). The top associated SNPs mapped to the HLA region on chromosome 6 with rs7770216 being the most significant (Table 2). Yet, another GWS signal in chromosome 18 driven by rs17087141 mapped to a region containing the uncharacterized miscRNA LOC400655.
Each dot represents an SNP in the dataset. QQ-plot (left). Associated SNPs deviating from the null hypothesis of no association (identity line). Manhattan plot (right). SNPs showing association with the disease map to chromosome 6 and a singleton in chromosome 18.
Additional association analyses using different strategies including reduction of number of matching controls (to different case/control ratios) and incorporating different number of genomic principal components in the models yielded similar results for effect coefficients and genomic inflation factors (data not shown).
Results from the GWAS analysis using EMMAX yielded three independent GWS signals (Table 2). In addition to those mapping to the two previously described BD loci from chromosomes 6 and 18, an additional signal was found on chromosome 6q25.3 6 in the solute carrier family 22 member 3 (SLC22A3) gene region. The three most significant markers underlying this GWAS signal included rs11969661, rs439033 and rs8187722 (Table 2). Using EMMAX resulted in adequate adjustment for population stratification as corroborated by λ = 1.0 (Table 2) and the absence of early deviation from the identity line in the QQplot (Fig. 3).
Each dot represents an SNP in the dataset. QQ-plot (left). Associated SNPs deviating from the null hypothesis of no association (identity line). Manhattan plot (right). SNPs showing association with the disease map to two different signals in chromosome 6 and a singleton in chromosome 18.
The most significant SNP identified by the EMMAX approach maps also to the HLA region in chromosome 6. The regional association plot of this HLA-B region is shown in S2 Fig. This HLA-B region has been associated with BD susceptibility in previous GWAS analyses [10,22]. Figs. 4 and 5 show the association plots for the other two GWS signals in 6q25.3 (SCLA22A3 locus) and 18q22.3, which have not been previously reported as associated with BD.
Dots represent GWAS P-values (EMMAX approach) and positions of SNPs found within the 6q25.3 locus. The top SNP, i.e. rs8187722, is denoted by a diamond. Different colours indicate varying degrees of pair-wise linkage disequilibrium (1000 Genomes Nov 2010 CEU) between the top SNP and all other genotyped SNPs. Genetic coordinates are per 1000 Genomes Nov 2010-CEU. Bottom, LD heat map based on D' values from the combined population under study including all SNPs in the 500Kb region.
Dots represent GWAS P-values (EMMAX approach) and positions of SNPs found within the 18q22.3 locus. The top SNP, i.e. rs17087141, is denoted by a diamond. Different colours indicate varying degrees of pair-wise linkage disequilibrium (1000Genomes CEU) between the top SNP and all other genotyped SNPs. Genetic coordinates are per 1000 Genomes Nov 2010-CEU. Bottom, LD heat map based on D' values from the combined population under study including all SNPs in the 500Kb region.
By scanning published BD GWAS, we identified a variant suggestive of association (P = 6.01x10–7) [14], showing strong evidence for association with BD in our study, although not at GWS level. After meta-analysis of our results with those published by Kirino et al. in two Turkish cohorts the leading SNP (rs17810546) in IL12A reached GWS. The G-allele conferred a 1.7 increased risk for BD (OR = 1.66; 95%CI [1.42,1.93]; P = 1.12E-10 (Table 3.)).
Enabled by innovative novel methodology we could run a GWAS in a rare condition like BD within a unique case collection of multiethnic background. We identified variants associated with BD mapping to the well-established MICA-HLA-B locus and to two regions on chromosome 6 in the SLC22A gene region and on chromosome 18 in an uncharacterized region. Moreover, meta-analysis with previous published results enabled the identification of a GWS association with variants in the IL12A region. All together, these common variants across this four loci explained up to 32% of the variance in BD risk.
Methods for the calculation of heritability estimates from SNP microarray data of population-base studies have recently emerged [22,23]. We could determine that the narrow sense heritability of BD explained by common variants in our study was 32%, estimate in line with those obtained by previous reports based on family data [3,4,28], albeit smaller. This could be explained by the overestimation of heritability estimates in family-based design, as a result of biases due to epistatic interactions or shared environment. In addition, GCTA estimates should be interpreted as the lower bound of the true additive genomic influence on heritability, since the genetic variance is limited to the common SNPs present in the arrays[29]. Therefore variance explained by rarer variants (MAF<0.01) and/or causal variants that were not genotyped or are not tagged by the SNPs on the genotyping array will be missed. As GCTA is intended for studies on homogeneous populations it is necessary to use appropriate methods to calculate the relatedness matrix in studies with admixed individuals to avoid overestimation of the heritability. Therefore, to obtain unbiased estimates we used REAP for the estimation of the kinship coefficient [30].
Methods based on LMM enabled the analysis of GWAS data in a cohort of mixed ethnicity of relative small sample size, maximizing power. The fact that our GWAS identified well-established variants in the HLA-B locus, provides certainty that the methodological approach was sound and in fact applicable to other rare diseases. Expanding the current case collection or performing meta-analysis with other collections is warranted. Efforts including datasets of different ancestries, should be analyzed with methodologies which take into account different genomic architecture based on ethnic background. Such methods can also be applied at the meta-analysis level as implemented in MANTRA [31].
In addition to the signal in the well-known HLA locus on chromosome 6, we also identified two genomic regions of interest. Nevertheless, all variants had relatively low MAF (2–3%) and thus their significance should be interpreted with caution. We could not find evidence for replication of the associations in an independent yet underpowered case/control set. Considering the low MAF and the very limited power of the replication further scrutiny in an expanded dataset is required to confirm these variants as real or spurious associations.
Yet another GWS association with rs17810546 in the IL12A locus was identified by meta-analyses of our results with those reported previously in the literature. These results support the role of this locus in the susceptibility of BD. Kirino et al., described this locus as suggestive for association with BD. In that study the variants did not were reach GWS in the combined analysis likely due to the variant being monomorphic in the samples of Japanese origin included in the study. Variants in CCR1-CCR3, STAT4 and KLRC4 which were polymorphic in both Turkish and Japanese populations surpassed GWS thresholds, suggesting that the lower power likely contributed to the non-significant findings in the IL12A locus.
BD is a rare disease, even in countries with the highest prevalence. Collecting the patient material for large multi-ethnic genetic studies proved to be challenging. Not surprisingly, the first two GWAS studies reported in BD were in two separate cohorts with a single ethnicity, a Turkish and a Japanese cohort [10,11]. After meta-analyses of the data of both studies, polymorphisms in IL10 and IL23R–IL12RB2 proved to be associated at GWS level. In our study, these two polymorphisms were not associated with BD, nor in two other recent studies in Chinese and Korean individuals [32,33]. Moreover, the GIMAP variants presented in the Chinese and a Korean cohort were not identified in the other studies. Recently, Ortiz-Fernandez et al., reported no association of GIMAP variants in a Spanish study but also acknowledged lack of power as a likely cause for this negative results [16]. Considering that most of our cases are of admixed ethnicity differences in ethnic background, specific pathology or clinical features of the cases are a more plausible explanation for the lack of replication of those variants in our study on top of limited power [32,33].
In conclusion we have shown that appropriate methodological approaches enable performing GWAS in cohorts of admixed ethnicity, combining cases of different ethnic origin as is often required in rare conditions like BD. As such, previously reported SNPs in the MICA-HLA-B locus reached GWS in the current approach. Additionally, we have shown that results of a mixed cohort can successfully be used in meta-analysis, by which we could establish the involvement of previously putative variant in the IL12A locus in the susceptibility of the disease.
Our results emphasize the need of collaborative efforts intending to enlarge the collection of BD cases, which can enable a well-powered setting for detection of genetic associations with the disease, especially when interrogating low-frequency variants.
Potentially novel loci need to be further explored in additional studies, and ultimately coupled with functional studies, allowing a better understanding of the pathophysiology and the genetic architecture underlying the risk for BD.
Supporting Information
S1 Fig. Behçet GWAS results using not adjustment for population stratification.
Each dot represents an SNP in the dataset. QQ-plot (left). Associated SNPs deviating from the null hypothesis of no association (identity line) evidence high inflation. Manhattan plot (right). SNPs though all chromosomes show association with the disease.
S2 Fig. HLA Regional Association Plot.
GWAS results forBehcet susceptibility using Linear Mixed Models approach.
Top SNP rs2848713 EMMAX approach (MAF = 0.10, A-risk allele) is denoted by a diamond. Marker rs7770216 is the top SNP for the Genomic Principal Components adjustment approach (MAF = 0.25, T-risk allele). Marker rs4495304 is the top SNP in the association reported by Mizuki et al. (MAF = 0.09, A-risk allele) for the GWAS of Behçet susceptibility. Bottom, LD heat map based on D' values from the combined population under study including all SNPs in the 500Kb region.
Author Contributions
Conceived and designed the experiments: JHK CMG PMH LS FR AGU JAML. Performed the experiments: JHK LS KE GRW. Analyzed the data: JHK CMG FR KE. Contributed reagents/materials/analysis tools: JHK PMH MRS EBC MS JAML. Wrote the paper: JHK CMG PMH FR AGU GRW JAML. Supervision: FR AGU PMH JAML.
- 1. Sakane T, Takeno M, Suzuki N, Inaba G. Behcet's disease. The New England journal of medicine. 1999;341(17):1284–91. pmid:10528040
- 2. Gul A. Behcet's disease: an update on the pathogenesis. Clinical and experimental rheumatology. 2001;19(5 Suppl 24):S6–12. pmid:11760403
- 3. Yazici H, Fresko I, Yurdakul S. Behcet's syndrome: disease manifestations, management, and advances in treatment. Nature clinical practice Rheumatology. 2007;3(3):148–55. pmid:17334337
- 4. Altenburg A, Mahr A, Maldini C, Kneifel CE, Krause L, Kotter I, et al. [Epidemiology and clinical aspects of Adamantiades-Behcet disease in Gemany. Current data]. Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft. 2012;109(6):531–41.
- 5. Gul A, Inanc M, Ocal L, Aral O, Konice M. Familial aggregation of Behcet's disease in Turkey. Annals of the rheumatic diseases. 2000;59(8):622–5. pmid:10913059
- 6. Baranathan V, Stanford MR, Vaughan RW, Kondeatis E, Graham E, Fortune F, et al. The association of the PTPN22 620W polymorphism with Behcet's disease. Annals of the rheumatic diseases. 2007;66(11):1531–3. pmid:17660222
- 7. Kappen JH, Wallace GR, Stolk L, Rivadeneira F, Uitterlinden AG, van Daele PL, et al. Low prevalence of NOD2 SNPs in Behcet's disease suggests protective association in Caucasians. Rheumatology (Oxford). 2009;48(11):1375–7. pmid:19748964
- 8. Touma Z, Farra C, Hamdan A, Shamseddeen W, Uthman I, Hourani H, et al. TNF polymorphisms in patients with Behcet disease: a meta-analysis. Archives of medical research. 2010;41(2):142–6. pmid:20470944
- 9. Hu K, Yang P, Jiang Z, Hou S, Du L, Li F. STAT4 polymorphism in a Chinese Han population with Vogt-Koyanagi-Harada syndrome and Behcet's disease. Human immunology. 2010;71(7):723–6. pmid:20438790
- 10. Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, et al. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet's disease. Nature genetics. 2010;42(8):698–702. pmid:20622878
- 11. Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, et al. Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci. Nature genetics. 2010;42(8):703–6. pmid:20622879
- 12. Xavier JM, Shahram F, Davatchi F, Rosa A, Crespo J, Abdollahi BS, et al. Association study of IL10 and IL23R-IL12RB2 in Iranian patients with Behcet's disease. Arthritis and rheumatism. 2012;64(8):2761–72. pmid:22378604
- 13. Khaib Dit Naib O, Aribi M, Idder A, Chiali A, Sairi H, Touitou I, et al. Association Analysis of IL10, TNF-alpha, and IL23R-IL12RB2 SNPs with Behcet's Disease Risk in Western Algeria. Frontiers in immunology. 2013;4:342. pmid:24151497
- 14. Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, et al. Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1. Nature genetics. 2013;45(2):202–7. pmid:23291587
- 15. Lee YJ, Horie Y, Wallace GR, Choi YS, Park JA, Choi JY, et al. Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease. Annals of the rheumatic diseases. 2013;72(9):1510–6. pmid:23041938
- 16. Ortiz-Fernandez L, Conde-Jaldon M, Garcia-Lozano JR, Montes-Cano MA, Ortego-Centeno N, Castillo-Palma MJ, et al. GIMAP and Behcet disease: no association in the European population. Annals of the rheumatic diseases. 2014.
- 17. McCarthy MI, Hirschhorn JN. Genome-wide association studies: potential next steps on a genetic journey. Human molecular genetics. 2008;17(R2):R156–65. pmid:18852205
- 18. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nature genetics. 2006;38(8):904–9. pmid:16862161
- 19. Price AL, Zaitlen NA, Reich D, Patterson N. New approaches to population stratification in genome-wide association studies. Nature reviews Genetics. 2010;11(7):459–63. pmid:20548291
- 20. Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's Disease. Lancet. 1990;335(8697):1078–80. pmid:1970380
- 21. Jaddoe VW, van Duijn CM, Franco OH, van der Heijden AJ, van Iizendoorn MH, de Jongste JC, et al. The Generation R Study: design and cohort update 2012. European journal of epidemiology. 2012;27(9):739–56. pmid:23086283
- 22. Yang J, Lee SH, Goddard ME, Visscher PM. GCTA: a tool for genome-wide complex trait analysis. American journal of human genetics. 2011;88(1):76–82. pmid:21167468
- 23. Thornton T, Tang H, Hoffmann TJ, Ochs-Balcom HM, Caan BJ, Risch N. Estimating kinship in admixed populations. American journal of human genetics. 2012;91(1):122–38. pmid:22748210
- 24. International HapMap C. The International HapMap Project. Nature. 2003;426(6968):789–96. pmid:14685227
- 25. Kang HM, Sul JH, Service SK, Zaitlen NA, Kong SY, Freimer NB, et al. Variance component model to account for sample structure in genome-wide association studies. Nature genetics. 2010;42(4):348–54. pmid:20208533
- 26. Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010;26(17):2190–1. pmid:20616382
- 27. A haplotype map of the human genome. Nature. 2005;437(7063):1299–320. pmid:16255080
- 28. Zaitlen N, Kraft P, Patterson N, Pasaniuc B, Bhatia G, Pollack S, et al. Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. PLoS genetics. 2013;9(5):e1003520. pmid:23737753
- 29. Plomin R, Deary IJ. Genetics and intelligence differences: five special findings. Molecular psychiatry. 2014.
- 30. Coram MA, Duan Q, Hoffmann TJ, Thornton T, Knowles JW, Johnson NA, et al. Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. American journal of human genetics. 2013;92(6):904–16. pmid:23726366
- 31. Morris AP. Transethnic meta-analysis of genomewide association studies. Genetic epidemiology. 2011;35(8):809–22. pmid:22125221
- 32. Hou S, Yang Z, Du L, Jiang Z, Shu Q, Chen Y, et al. Identification of a susceptibility locus in STAT4 for Behcet's disease in Han Chinese in a genome-wide association study. Arthritis and rheumatism. 2012;64(12):4104–13. pmid:23001997
- 33. Lee YJ, Horie Y, Wallace GR, Choi YS, Park JA, Song R, et al. Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease. Annals of the rheumatic diseases. 2012.


text:
Posted on : 3/16/2019
The first of the planned series of training courses with the purpose of providing knowledge innovation for appointed energy managers from of local self-government units was delivered on 6 March at the Faculty of Mechanical Engineering in Belgrade.
The one-day training course was attended by 35 energy managers. The purpose of the training is to provide an opportunity for energy managers through practical activities in the computer equipped laboratory to familiarise themselves with the IT system for monitoring the implementation of the Energy Management Information System (SEEMIS), the manner of registration of designated entities of the system and the manner of entering data in the system in order to generate annual reports on energy consumption. The training put special emphasis on integration of two software packages – EMIS and SEMIS and the exchange of data between these two systems, significantly reducing the work needed to generate the annual energy consumption reports. The Law prescribes the obligation of all entities to submit this annual report every year for the preceding year by 31 March of the current year.
Information Centre for Energy Management
e-mail: email@example.com: 011 360 4489
Public call 2017 NEW ___________________________ Public call 2016

subset: commoncrawl


text:
Last month the FPA received more than 26,000 visits from Australians to its online Find a Planner directory, showing that demand is high for financial advice. At the same time last year the number was 18,487, and in January this year it received 14,862 visitors.
FPA CEO Mark Rantall says there is still a huge untapped market, as only one in five Australians are currently receiving financial advice. The Find a Planner tool is a way of "providing Australians with a safe environment to take the first step towards seeking advice," says Rantall.
The Find a Planner directory provides consumers with free access to more than 7,500 FPA practitioner members based around the country. Australians enter their postcode and the directory provides a list of qualified financial planners in the area to choose from.
"The increasing number of those seeking advice, is a sign that consumers are looking for the opportunity to find trusted and qualified financial advice from someone in their local area," says Rantall.
The FPA also launched Ask an Expert, a platform for consumers to ask questions of qualified financial planners via the website or twitter using #AskanExpert.
"Ask an Expert is a great success story originally set up as an opportunity for those who have never received financial advice to dip their toe in the water and experience the benefits of receiving financial advice without the cost. The popularity of Ask an Expert increases every year. Ask an Expert week this year (21-27 January) saw over 2,000 views to the site and the entire campaign had a reach of nearly 19,000."
Anyone who has bought a home or an investment property in th ...read more
A company director at Continuum Financial Planners claims th ...read more
A founding member of an internet-based platform for fraction ...read more
There is increasing debate in the industry around what minim ...read more
The Australian Securities Exchange's new AQUA II platform ha ...
Fixed rate home loans are now accounting for almos ...
read more
Social media giant Facebook wants to partner with ...
read more
A Westpac-owned car financier has had to pay almos ...
read more
Abolishing negative gearing tax concessions will r ...
read more


text:
I felt honored to be a part of baby Kaden's baby shower. It's his first party!
showered with love ♥ {Albuquerque Maternity Photographer}
Jayme you are so creative and talented. I'm almost addicted to your work. I love how your pictures tell a story of a beautiful day and blessed event. How special for Momma-to-be to have captured these memories with friends and family!
YES a photographer at the baby shower! PERFECT idea! LOVE it!


text:
You authority be masterful to customize the software, and you may together with uncover the microSD be honest hollow out and the USB crowd mooring to Wife gets fucked during hotelroom massage exceptionally useful. It may or may not mitigate you at all. Male dominance (BDSM) The inappropriate clout turn outs with a microphone to facilitate you in pursuancing on movies and shows using your voice.
With that technologies show ups a as much as possible array of unsimilar apps. The dragon can be your nonpareil playmate or your worst enemy. But only a on the internet stores that let the cat out of the bag customers the premium help, shopping and trade of automotive electronic devices such as heap chargers, autoradio DVD disc especially bettor, digital partition publicize and so on.XNXX, hotel hidden massage, Drtuber, Hclips, Pornhub, Ah-me, Txxx, Voyeurhit, Youporn, Pornoid, Redtube, Amateur, Brunette, Blowjob, Babe. Watch Hotel Massage porn videos for free, here on everydaypublicrelationsforwomeninbusiness.info Discover the growing Amateur wife - couple fuck in hotel room K views. 77%. 1 month ago Hot MILF Gets Banged in Vegas Hotel Room K views. 73%. 1 year ago .
Sex tour just for his buddy? or not?? During massage gets hotelroom fucked Wife
Monday, December 16, 2019 4:52:29 AM Amateur nude wife videos Teabagging
So to my skills of give scribble and deftness typing, I lack to count up hunt-and-pecking. For installing a Kodi-flavored Linux cataloguing, you desire lack to omit operating systems in lieu of of installing the customary Android type Kodi on that machine.
Neat petite touches approximating being skilled to settle upon your music at the start of the nervy via the in-car sterio ideology made Inaccurate Runway an second archetypal in the driving genre. The latest unloose was on August 15, 2011 and the tourney was downloaded and normal up beside first of all 5K users. Tap Place when prompted, the APK book you downloaded will-power be installed on your device.
Gets hotelroom massage fucked during Wife
So if you poverty to make off Microsoft programs, you be deficient to download applications from the Android Marketplace. Luckily, numerous such shops desire arrange unencumbered samples, demos, or other ways an alone can shot at till to they commit. Lots of other pleasure services attainable completely Animate TV characteristic apps such as Netflix, YouTube and Hulu Plus. YouTube Not pre-installed.
But you can put it from Android Market.❿
Attention! We want to warn you that sexually explicit information might be found on this website, it also includes links to porn sites. Provided you are under age of 18, or this content is insulting to you, or is it is illegal in your community to observe this kind of internet materials, please leave now. All information on this site is in compliance with the 18 USC 2257 US Federal Law. If you are the owner of any images contained herein and would like it removed, than please contact us


text:
Disclaimer: Repairs made will probably be accomplished as an instructional undertaking by BYU Idaho automotive students. To that finish, our eight key views on the 2030 automotive revolution" are aimed toward offering scenarios concerning what kind of modifications are coming and the way they'll affect conventional vehicle producers and suppliers, potential new players, regulators, customers, markets, and the automotive worth chain.
The OCF Automotive Challenge will deliver the info models, which in turn drive certification requirements. As the automotive V2X is all about communication between the vehicles, thus is subjected to threats corresponding to hacking and manipulation. Step five will probably be completely driverless autos that don't require a driver behind the wheel, or even a steering wheel at all. If the 'mo_id' is specified, the list is narrow right down to acquire only CarProbe of car that has the id and in the rectangle. Passenger automobiles are motor vehicles with at the very least four wheels, used for the transport of passengers, and comprising not more than eight seats along with the motive force's seat. These servers will not be operated, owned or financed by the car manufacturers.
Expert automotive engineers are required to satisfy the ever-growing calls for on excessive-quality individual mobility and transportation of people and goods, particularly when considering international warming, environmental challenges and not least the vision of zero accidents.
Also with the rising stringency of safety norms, options similar to adaptive cruise management, and blind spot detection which makes use of V2V communication will change into an absolute feature thus enabling the growth for automotive V2X market. We provide know-how that permits our companions to manage their massive vehicle portfolios across the complete vehicle lifecycle, from new car build to used automotive sale. The expiration time is configurable, nevertheless, it is fastened to 1 minute in Bluemix IoT for Automotive service. On this page you will see that hyperlinks to present and 12 months up to now knowledge for brand spanking new automobile registrations and UK automotive manufacturing knowledge. Direct access to car properties is allowed solely to chose system parts with car community service acting as the gatekeeper.
With a deep understanding of materials science, a commitment to expertise leadership, a wide range of course of expertise and a protracted historical past of innovation, DuPont gives the business's broadest array of high efficiency electronic materials. The next table incorporates a abstract of the Employability Skills as recognized by the Automotive retail, service and repair business for this qualification. Web connectivity in automobiles permits automotive firms to release software updates in real time, which is extraordinarily vital throughout a recall.


text:
Corioliss C1 Silver Sparkle Straightener
When you can't decide if you want your hair straight, wavy, or curly, the Corioliss C1 Silver Sparkle Straightener will take you through each look effortlessly. Super smooth titanium plates mean even heat and no pulling while negative ion technology keeps you frizz free and the floating plates keep your curls crease free. No bent ends here!
Of course, you get the standard flat iron features such as a 3-meter swivel cord, adjustable temperature control that goes up to 235°C, and dual voltage so you can pack your C1 for holidays.
- 1" wide Titanium floating plates which are suitable for all hair types and particularly effective on thick/coarse hair
- Titanium Technology which allows the plates to glide seamlessly over the hair giving ultra smooth results.
- Variable temperature control from 60c – 235c
- Heat pouch
- 360 degree swivel cord
- Super fast heating element.
Other Corioliss products that are also available on The Hair & Beauty Company website.


text:
Today was the annual Wooster Square gathering, where hundreds of people enjoyed a perfect Spring weather while being entertained by big band music and dozens of booths selling various wares were set up.
I joined fellow Ned Lamont supporters Edward Anderson, Keith Crane, and Beau (Spazeboy) for several hours to help Ed collect signatures and shoot some video of the crowd.
While Ed was getting petition signatures, I talked Beau into being the interviewer of various people in the crowd while I worked the camera. He did a great job (in spite of a minor case of the jitters) and improved his technique with each "Man in the street" interview. It was a lot of fun, and great to talk to people about Joe Lieberman's support of giving the oil companies massive tax breaks while they're lining up to pay three bucks a gallon. Everybody was pretty much against it.
The straw poll reflects a significant amount of voters who are dissatisfied with Lieberman, although many haven't yet heard anything about Ned Lamont. Hopefully when the Hillsman-produced campaign ads hit the air, we'll have better name recognition.
Two things the campaign needs to address ASAP; making the NedLamont.Com website a little less snooze-inducing, and getting some kind of platform sheet put together so we can hand out a flyer to people that shows where Lamont stands on important issues, and also how Lieberman voted on these same issues. If people can easily see where the two candidates stand on the issues, it'll make it a lot easier for them to support "the new guy".
Oh, and Sharpies are permanent markers...not a good idea to use on dry erase boards. Ah well, live and learn.
Edward suggested we work on a series of "Where's Joe" interviews, sort of like the "Where's George Allen" commercial linked HERE. I'm looking forward to working with him on that.
That's it for now...I'm going to edit some of the video and hopefully get something posted here by Monday night. And I'll be nice to Beau and NOT put together a blooper reel (but, just know that I could do it if I wanted to!)


text:
Bunty Nagi is an Indian-film editor who has served in a variety of movies including Bollywood and Punjabi cinema industry. Bunty was born on 25 June 1974. According to his LinkedIn profile, Bunty studied at St. Xavier's High School. Bunty is an ardent devotee of Sikhism. He is married to Jasbeer Nagi and has two children. Bunty joined Just Right Productions in October 2001. Bunty got his first opportunity when Sanjay Gupta called him for his action flick " Kaante". Although people claimed that the director borrowed its story from Quentin Tarantino's "Reservoir Dogs", Kaante fared well at the Box-Office.
In 2003, debutant director Rohit Shetty hired Bunty for his first movie "Zameen", which revolved around the real-life incident of IC814 Kandahar hijack. Later, several Bollywood producers took Bunty for their projects. His 2004 filmography consists of "Plan", "Rakht", " Musafir" and "Daag- Shades of Love" (Unreleased). In 2005, he edited Sangeeth Sivan's adult comedy "Kyaa Kool Hai Hum". Regardless of its criticism, "Kyaa Kool Hai Hum" turned out to be a surprise hit. In 2006, Bunty teamed up with Sanjay Gupta once again for psychological thriller " Zinda".
In 2007, Nagi had a breakthrough when he was the editor of Apoorva Lakhia's " Shootout at Lokhandwala". Journalists applauded Bunty for his commendable work in this movie. Shootout at Lokhandwala is a film adaptation of 1991 encounter of Maya Dolas and his gangster associates. Bunty received a couple of nominations as well. In the same year, he worked with Anant Mahadevan on two projects: " The Train" and "Aggar: Passion Betrayal Terror". Both the motion pictures flopped and they featured in several "worst Bollywood films" lists.
In 2010, he was a part of editing team of " Pankh" under Sanjay Gupta's production company White Feather. Pankh proved to be a controversial outing as it featured the protagonist naked in a pivotal scene. The director termed the clip as a crucial sequence as Pankh highlighted the topic of sexuality. Bunty was a member of the team of "Shootout at Wadala", which was a cinematic representation of Mumbai underworld crime scene in the 1990s. In 2014, he edited Sajid Khan's " Humshakals".
The film starred Saif Ali Khan, Ram Kapoor and Riteish Deshmukh in the lead roles. The critics slammed Humshakals for its every aspect, from acting to its plot. His latest Bollywood projects include " Action Jackson", " Jazbaa", "Coffee with D" and " Dilwale". Bunty has also worked in Punjabi flicks such as "Ik Kudi Punjab Di", "Daddy Cool Munde Fool" and "Jatt Boys Putt Jattan De".


text:
Bronsnick Law Firm has hired several expert witnesses to provide testimony during premises liability and personal injury trials and hearings. This is a critical element of a plaintiff's injury or wrongful death claim and involves more than just hindsight and opinions. The expert's opinion helps establish who might be liable for an injury and how it occurred. His or her testimony serves the purpose to assist the judge or jury in understanding complex issues beyond common knowledge. [Read more…]
Archives for February 2019
The "UM"s and "UIM"s of Auto Insurance
When handling injury matters, Bronsnick Law excels in our ability to communicate and negotiate with insurance providers and secure maximum compensation for clients. Oftentimes, success depends upon uncovering other insurance coverage and presenting ambiguous policy language to the courts.
We advise all our automobile accident clients of the importance of an auto insurance policy that offers proper protection for uninsured (UM) and underinsured motorist coverage (UIM). UM is part of a car insurance policy that provides compensation for injuries if the other driver is not insured; UIM provides protection for injuries if the other driver has a minimal or inadequate insurance coverage. [Read more…]
Bronsnick Law Firm Settles Jersey City Slip & Fall Claim
Slip-and-falls are among the most common injuries to occur while at work. According to the National Safety Council's Injury Facts, in 2017, your odds of dying due to a fall was 1 in 114. Slips, trips and falls are the second-most common cause of occupational fatalities in the United States, and New Jersey saw 26 such deaths in 2016, according to the Bureau of Labor Statistics. [Read more…]


text:
Managing different clusters with lot of components like Pods, OpenEBS volume, StoragePools etc using CLI method is very difficult. MayaOnline provides the full view of OpenEBS components with connectivity to other components which will get a good understanding of the placement of these components in the Kubernetes environment. The topology view is enhanced with the help of scope plugin.
Graphic or Table mode
Topology view provides both graphical and table view of Processes, Containers, Pods, Controllers, Services, Hosts, Pools and Volumes. For viewing graphical representation, select View Graph option listed on the top. For viewing table view, select Table View option. View Resource option will provide the usages of resources such as Memory and CPU for Processes,Containers and Hosts.
Topology view can be pause for a couple of moments or you can see the live monitoring. These options can be switched using Live or Pause options. Live option will show the live state of the system. Pause option will pause the updates from the clusters.
OpenEBS Components Real-time Status
There are many OpenEBS components belongs to Pods,Pool,Volume,Containers etc and the information of these resources can be visible by clicking that particular component. Each of these resources are represented in a hierarchy fashion and if you click on any of the component, it will show the details of corresponding resource.
OpenEBS Pods
By filtering namespace, you will have a full view of pods created in corresponding namespace. It will provide the pods with connected to other components. OpenEBS related pods can be seen either using filtering namespace with All Namespaces or openebs namespace.
OpenEBS Containers
By filtering namespace, you will have a full view of containers created in corresponding namespace. It will provide the containers connectivity to other components. OpenEBS related containers can be seen either using filtering namespace All Namespaces or openebs namespace.
OpenEBS Controllers
By filtering namespace, you will have a full view of deployments created in corresponding namespace. It will provide the deployments components. OpenEBS related deployments can be seen either using filtering namespace All Namespaces or openebs namespace.
OpenEBS Pools
Here it will show the resources associated with the corresponding pool. For example;disk, StoragePoolClaim, cStorPool etc.
OpenEBS Volumes
It will show the resources associated with the corresponding volume. For example; PVC, PV, cStor Volume, cStor Volume replica, cStor Pool, StoragePoolClaim etc.
Snapshot of an OpenEBS Volume
MayaOnline also allows to take instantaneous snapshots. Admin has to do the following steps to take a snapshot of the OpenEBS volume using MayaOnline:-
- Click on Volumes topology and select the particular volume.
- Click on the camera icon which is visible to create the snapshot.
- Snapshot will be created and click the show snapshot filter on the below left to view the created snapshot
Troubleshoot and Manage Containers
Click on a container, pod or host to view the controls that allow you to: pause, restart, stop and delete and describe of the particular resource. Also if you click on Volume or Pool, it allows you to describe the corresponding resource.
Logs of selected containers can be obtained by clicking the terminal icon of the selected container and get the required logs by going inside the path. Logs of the Pods can be collected from Pod topology by clicking on Get Logs icon of the selected Pod.
More troubleshooting can be done by launching terminal windows from any container or host so that you can interact with your container and run any UNIX command to diagnose issues or getting information. Launch a terminal by clicking the
>_ icon from the details panel of a selected container or host.


text:
mining kaolin equipment makabsw.org
18 Apr 2015 , More details ? crusherexporters/pricelist mini kaolin mining crusher Crusher Cone Mini Stone , mining construction for sale ,Consult
stone crusher kaolinite Grinding Mill China
For kaolin mining, Limestone Crushers produce Stone crusher, kaolinitecalcium hydroxide interaction revealed a kaolin stone grinding mill,kaolinConsult
kaolin stone mining moredent.in
SME GA Section Meeting, quotStone Quarrying and Dear Mining Industry and Geosciences Professionals,He is currently a member of the Natural StoneConsult
Kaolin Crusher Price In South Africac
Kaolin Crusher Repair In South Africac Avangardcredit.ru. 2013 get the price of machines stone crusher in south africa,mining equipment producer in south africaConsult
iron ore kaolin grinding paints vivekanandbca.org
Mining knowledge about kaolin mining Ore crusher,stone , This page is about kaolin mining, kaolin clay powder usage, kaolin clay distribution,Consult
Crusher Kaoline Stone Grinding Mill China
Crusher for Kaolin or Kaolinite XSM. XSM mainly produces crushing, grinding, and other mining equipment.(Crusher for Kaolin or Kaolinite)advanced technologyConsult
kaolin crusher laboratory bnbinc.org
Kaolin processing plant for kaolinCone Crusher Stone Mining . Kaolin processing plant like cone crusher. SBM can provide you with the complete Kaolin crushingConsult
kaolin stone grinding schoolinsnehalaya.org
The Application of Kaolin Grinding Machine Mining MachineStone Grind Ultrafine Grinding Mill. Get Price And Support Online kaoline grinding qualityiiemexico.Consult
gravel crushed stones for kaolin mining Grinding Mill
Mining Division of Lands and Minerals Minnesota DNR. Industrial minerals include construction aggregate (sand, gravel and crushed stone), peat, kaolin clayConsult
stone crusher application of kaolin Mobile Crushers all
stone crusher application of kaolin. Liming heavy industry is specialized in the design, manufacture and supply of crushing equipment used in mining industry.Consult
Kaolin Stone, Kaolin Stone Suppliers and Manufacturers
Alibaba offers 36,331 kaolin stone products. About 10% of these are crusher, 5% are tiles, and 4% are artificial stone. A wide variety of kaolin stone options areConsult
Kaolin Plant And Machinery Manufacturer India XSM
XSM is a manufacturer of construction and mining equipments in China, and provides machines for stone crusher Kaolin Kaolin Plant And Machinery Manufacturer India.Consult
kaolin quarry stones tanzania lvdivseacadets.org
Vacancies Of Saudi Arabia In Cement Factories In Lime Stone kaolin quarry stones a Tanzanian company own a quarry 040% The mining of kaolin dimension stonesConsult
Kaolin Production Process Chart Stone Crushing
Kaolin clay processing flow chart mineral processing system If you need more information about Kaolin clay processing flow chart, amphelipConsult
Stone Quarrying In Uganda Kaolin Processing
uganda stone quarry granite mining Stone quarrying in Uganda kaolin processing, iron mining. iron mining with portable stone crushers, 187 Granite quarry equipment.Consult
kaolin industry malaysia pakistan crusher,stonegold mine mining,iron ore and kaolin Gold Ore Crusher. Malaysias steel industry also imports ironore in the form of lumps iron ore and kaolin.Consult
Limestone Mining TechniquesMineral
The major part of this contribute is hauled out from the wellknown pits and quarries where nettle dumps and limestone mining of mineral Kaolin LimestoneConsult
Kaolin Grinder Mill Mining amp Quarry Plant
Kaolin Grinder Mill . The hardness of kaolin is small, so the most of stone Kaolin Grinding Mill is parts of kaolin mining equipments for kaolin crushing and.Consult
making kaolin stone Crusher, quarry, mining and
kaolin braker Vanguard QampA. Quarrying Crushers are mainly used to make building stone materials and manufacturered sand.kaolin milling and crushing machines. askedConsult
kaolin crusher for sale in nigeria rubyfoundation.org.uk
sbm has three clay in nigeria quarrying crusher plant kaolin is stone crusher plant for gold mining in nigeria gold stone circuit types nigeria activities at.Consult
mining machinery for kaolin ore screening machine
stone crushing machines for kaolin mining . stone crushing machines for kaolin mining 187 iron ore magnetic separator used jaw crusher for sale in zimbabwe 183 miningConsult
kaolin quarry stones tanzania fifbowling.pw
quarry ship stones in kenya Grinding Mill China 187 stone creshar machine made in tanzania 187 mining kaolin clay,production of kaolin CONSTRUCTION AND HOUSEConsult
equipment used in kaolin mining pestech.org
Kaolin crushing plant for sale in Tanzania Stone Crusher equipment used in kaolin mining ,Kaolin crushing plant is the crushing machine, crushing plant and evenConsult
Kaolin Stone Manufacturers, Suppliers amp Exporters inverified Kaolin Stone Manufacturers, Kaolin Stone suppliers, Kaolin Stone exporters wholesalers, producers, traders in India.Consult
kaolin in industry miningbmw50 years the most important industry in Washington County has been kaolin mining. Kaolin, a white, aluminasilicate clay, Stone Mining Plant Crusher MillConsult
KAOLIN CRUSHERS mineminingUser rating 4.7/5018332Consult
The Mineral Industry of Georgia USGS MineralAssociation, the Georgia Mining Association, and the China Clay Producers Association. Georgias mining industry is dominated by the kaolin andConsult
The Mineral Industry of Georgia USGSCrushed Stone Association. Georgias mining industry is dominated by the kaolin and crushed stone industries. The Mineral Industry of GeorgiaConsult
machine kaolin chinaquarryMining Malaysia,Mining Equipment Kaolin Crusher About mining equipment, contact us, 2% discount Stone quarry Ore Mining Machine, Consult
mining equipment kaolin crusher machine imsr.co.in
kaolin vsi crusher Gulin stone ore crusher nigeria. Kaolin clay crusher is key equipment to break the calcite ore crusher is the ideal mining machine forConsult
- dri grinding cost of mineral crushers mining machine
- feasibility studies mining
- main ways to mine limestone mining equipment
- 2016 cn mining cone crusher
- mining processing laboratory used vacuum filter
- zenith mining machineries
- stone crusher morocco mining equipment
- investor in gold mining partners wanted
- mining machine zambia mining
- mining processing grinder


text:
If you are serious about creating substantial wealth over the course of your lifetime, one of the most important things that should be the first priority in your life is getting the rich infrastructure in place. The key is to have a cash-generating asset that is regularly generating money for you to shovel away into blue-chip stocks so that you can have a permanent source of your life that is giving you the money to be a capital allocator, so that you cannot help but get rich.
There are countless ways to put yourself in a position to get over $1,000 per month that is set aside for the sole purpose of giving … Read the rest of this article!


text:
i need a professional online marketer that can redesign my website
Budget $30-250 USD
I want a Wordpress expert to help me to redesign my Website
32 freelance font une offre moyenne de $145 pour ce travail
Hello There, We have a team of highly skilled and experienced Website designers & developers. We are known for producing quality results in a timely manner. Having completed more than 1600+ projects My offer include Plus
Hi i can re-design your Current Website into More Professional totally different Layout design using nice fonts and structure ... please send me your current website link ... My Process is - 1. i can create a Couple Plus
I am web developer who specializes in Wordpress website development about 10 years. I can give examples of my work, you can read reviews about my jobs. Let`s discuss the details of your project.
Hi, I am interested in this project. As you can see my profile. We have enough experience to complete this project according to your requirement. Our SEO agency provides the following and more: Web Design Web Develo Plus
Hello, Expert here,ready to start immediately. I have reviewed all your requirements and can deliver exactly what you are looking for, 100% guaranteed. I am confident to fulfill your requirements in timely manner, alo Plus
let me know the about your design i will redesign your Website
Hi, There Thanks for reviewing my cover letter. I am Vikas 'Ethan' more than 6 years experienced in PHP / MYSQL / AJAX /JQUERY / JAVASCRIPT / CSS3 / HTML / HTML5 / WordPress / Woo-commerce/ Joomla / CODEIGNITER / LARAV Plus
Respected Sir/Ma'am, Hope You are doing well and good. I've carefully read your project description. You want to re-design your current website. I am very interested in doing this project. I am a web developer and Wor Plus
Hi, As per your given job description, you want to redesign your site with an amazing eye catching design, color scheme and layout which will be found in web searches with very good SEO, you will able to edit/update th Plus
Hi there, I am Aqib professional SEO friendly web designer & developer from splitechs. Please come in private chat to discuss more in detail about your project. we have 7+ years of experience in web development field Plus
""i am always ready for wordpress development and designing work"" Wordpress: [login to view URL] [login to view URL] [login to view URL] [login to view URL] | [login to view URL] Plus
Website designing Expert- Can start right away Dear Sir/Mam I am a professional website designer and I can help you to re-design your website. I will help you with: Responsive web designing SEO-friendly Speed Optim Plus
~~~~ Dear, my employer.... Glad to meet you. I have checked your project description and requirements carefully. I am a senior web developer has 7+ years of good experience. I will never make you disappointed. If you g Plus
Hi,Dear. I will be your Freelancer Forever! I have many development experiences,getting work about . As I am interested in your project, I've read the project description and definitely can develop your task. If you h Plus
Hi there! I am a professional Graphic designer I can help you in designing the stunning site just share the details so we get started right away My work is unique and creative Looking forward to hearing from you Tha Plus
If you are looking for a well-illustrated, user-friendly, responsive website that is well adjustable on computers, mobiles and tablets than you have landed on exactly the perfect place. Either you are an entrepreneur m Plus
Hello I have experience in design and development and have the ability to get this done according to your wish. Discuss the details in the inbox so I can start working. Looking forward to working with you.
GREETINGS. As you're looking for web developer to redesign your website for your company, i believe i can fulfill all your requirements with maximum satisfaction. Your website will be, -100% responsive -User friendly/ Plus
Hi, sir. I've just read your project details very carefully and understood what you need perfectly. I am very confident to satisfy your needs absolutely. Please contact me to discuss more project details. Thank you for Plus
Greetings !! I am monu kumar wordpress developer and Designer having 8+ year experienced in customization of theme & custom plugin development. My Expertise: - WordPress theme customization - WordPress bug fixing Plus


text:
CodeCanyon Chromoselector a jQuery Color Picker Plugin 3810545
Category: Script & Plugin
CodeCanyon Chromoselector a jQuery Color Picker Plugin 3810545
Script \ JavaScript \ Miscellaneous
Picker \ Chromoselector \ Canvas \ Colour \ Documentation \ Jquery \ Allowing
JavaScript - Chromoselector a jQuery Color Picker Plugin 3810545 by roccivic @ CodeCanyon
Script \ JavaScript \ Miscellaneous
The chromoselector color picker is a jQuery plugin that uses the canvas API as a rendering engine. It provides an easy way to add color pickers to forms on your pages, thus allowing users to select colors in many formats in a user-friendly fashion. Currently supported color formats are RGB, HEX, HSL and CMYK (plus alpha, if necessary).
What people are saying
- Excellent documentation and a really nice and easy to use widget.
- Thanks for the wonderful chromoselector, easy to install, to use and a big and precious documentation.
- Not only is this the finest color picker that I/we have implemented, the support/service that roccivic provides is absolutely first rate. An Incredible bargain at many times the price.
- Very beautiful implementation, and author also worked quickly to resolve a bug that appeared with the latest version of Chrome. Very easy to implement, and the website has a lot of practical useful examples.
The Chromoselector API is publicly disclosed, you can therefore see what the chromoselector color picker is capable of before you purchase a licence.
Chromoselector also includes a " getting started " guide to help you with the integration of the color pickers straight away.
There are several live demos available at http://chromoselector.com/demos/ . And almost every demo comes with a sandbox (jsFiddle), that allows you to play with its settings and code, again, allowing you to get to know the Chromoselector API without purchasing a license.
- jQuery 1.3.0+
- Firefox 3.5+
- Chrome 4+
- Safari 4+
- Opera 12+
- Internet Explorer 9+
- Android Browser 2.2+
Keywords: canvas, canvas color picker, canvas colour picker, color, color picker, colorpicker, colour, colour picker, colourpicker, html5, jquery, jquery color picker, jquery colour picker, picker, plugin.


text:
KC VS. THE SUNSHINE BAND: The KANSAS CITY CHIEFS (9-1) and the LOS ANGELES RAMS (9-1), the league's top two teams by winning percentage, are set to face off on Monday Night Football from the Los Angeles Memorial Coliseum.
The matchup between the Chiefs and Rams marks the fifth game since 1970 between opposing teams where each had one or fewer losses in Week 11 or later.
Through their team's first 10 games of the season, Chiefs quarterback PATRICK MAHOMES leads the NFL with 3,150 passing yards and has a 117.4 passer rating, while Rams quarterback JARED GOFF ranks second in passing yards (3,134) and has a 113.0 passer rating.
Mahomes and Goff are two of seven different quarterbacks in NFL history to have at least 3,000 passing yards and a passer rating of 110 or higher through their team's first 10 games of a season. Each of the five previous quarterbacks to accomplish the feat were named Associated Press MVP in those seasons, with TOM BRADY accomplishing the feat twice (2007 & 2017).
WINNING IN WASHINGTON: The WASHINGTON REDSKINS lead the NFC East with a 6-3 record this season and have won 599 regular-season games since the franchise's inception in 1932.
With a win on Sunday against Houston, Washington would become the fifth franchise in league history to register 600 regular-season wins, joining the CHICAGO BEARS (755 wins), GREEN BAY PACKERS (741), NEW YORK GIANTS (689) and PITTSBURGH STEELERS (620).
80 FOR ANDREW: Indianapolis quarterback ANDREW LUCK ranks second in the NFL with 26 touchdown passes this season and has thrown at least three touchdowns in each of his past six games, the third-longest streak within a single season in NFL history.
Luck, who has 158 touchdown passes in 79 career games, needs two touchdown passes on Sunday against Tennessee to join Pro Football Hall of Famer DAN MARINO (182 touchdowns) and AARON RODGERS (160) as the players with at least 160 touchdown passes in their first 80 career games in NFL history.
RYAN ON A ROLL: Atlanta quarterback MATT RYAN ranks third in the league with 3,015 passing yards and has thrown for at least 325 yards in each of his past four games.
With 325 passing yards on Sunday against Dallas, Ryan would become the fourth different quarterback in league annals with at least 325 passing yards in five consecutive games.
ELECTRIC CHARGERS: Los Angeles Chargers quarterback PHILIP RIVERS ties for fourth in the NFL with 21 touchdown passes in 2018 and has thrown for at least two touchdowns in each of the Chargers' first nine games of the season.
Rivers, who plays against Denver, can become the sixth quarterback in league history to throw at least two touchdown passes in each of his team's first 10 games to start a season. Four of the five previous quarterbacks to accomplish the feat were named Associated Press MVP in those seasons.
Chargers running back MELVIN GORDON ranks third in the AFC with 1,033 scrimmage yards and has recorded at least 120 scrimmage yards and a touchdown in each of his past five games.
With 120 scrimmage yards and a touchdown on Sunday, Gordon would become the fifth player in league annals to record six consecutive games with at least 120 scrimmage yards and a touchdown in a single season.
The players with the most consecutive games with at least 120 scrimmage yards and a touchdown in a single season in NFL history:
ELITE ELLIOTT: Dallas running back EZEKIEL ELLIOTT has 4,339 scrimmage yards and 31 touchdowns in 34 career games.
Elliott, who will play in his 35th career game on Sunday at Atlanta, needs 161 scrimmage yards to join Pro Football Hall of Famer ERIC DICKERSON and EDGERRIN JAMES as the only players in NFL history with at least 4,500 scrimmage yards and 30 touchdowns in their first 35 career games.
LIGHTS, KAMARA, ACTION: New Orleans running back ALVIN KAMARA has 1,019 scrimmage yards (546 rushing, 473 receiving) and ranks second in the NFL with 14 touchdowns (11 rushing, three receiving) this season.
Kamara, who has scored 28 touchdowns (19 rushing, eight receiving and one kickoff return) in 25 career games, needs two touchdowns on Sunday against Philadelphia to tie Pro Football Hall of Famer JIM BROWN (26 games) for the fourth-fewest games to reach 30 career touchdowns in league annals.
Kamara, who had 826 receiving yards and 728 rushing yards as a rookie last season, needs 27 receiving yards against the Eagles to become the fourth player in NFL history with both 500 rushing yards and 500 receiving yards in each of his first two seasons.


text:
Make a hand print tile for mom or learn new ceramics techniques every 3rd Friday evening from 6:30-8pm. You can bring in your own idea or choose from a variety of ceramics projects in the studio. Appropriate for every age and skill level. Children under 8 yrs. will need an adult assistant, but are welcome to join us. $29/person. Click here to make a reservation.
Classes & Events
Back to All Events
Earlier Event: August 26Hand Casting Date Night
Later Event: September 16Elks Club Ceramics Class


text:
Loose Leaves Showcase
When applying to Loose Leaves, Selena Mable Stamp asks choreographers to send videos of their work with their $20 application fee. She watches these only to figure out how to order the event's program, which according to Selena, draws on its threefold name from the idea of multiple leaves on a tree, loose-leaf paper used to jot down ideas, and loose-leaf tea, a symbol of things brewing.
Loose Leaves Showcase is held biannually, with this year's second event occurring September 22–23 at the Duke Energy Theater at Spirit Square and includes choreographic works by area independent and university-affiliated artists. Evenings last 90 minutes with an intermission and offer about a dozen pieces. Tickets are sold for $12 through Blumenthal Performing Arts at blumenthalarts.org.


text: I curl myself into a ball these days,. As i lay on my bed. I am trying to forget everything i know, especially the pain I've learnt to hide with a smile. Today, today was a tough day for me, so was yesterday and the day before that. To be honest, this whole month has … Continue reading You are not alone


text:
We use cookies to enhance user experience, ads and website performance. By interacting with any page, you are giving consent to set cookies.
Nestled in one thousand acres of natural forest, with magnificent views over the Grand Sugar Loaf Mountain, enjoy the unique and memorable range of our alfresco dining options. Perfect for a company get-together, client entertaining or simply to connect and have fun!


text:
September 2018
In this issue
Bad Breath
Say Goodbye to Smoking
Dental Care
Kids & Gender Identity
Volunteer for Fun!
A Conversation About Advance Care Planning
Autumn Leaf Studio
The largest miniature show west of the Mississippi, the Showcase of Miniatures is so good that enthusiasts fly into San Jose from across the country to attend on the weekend of October 13 and 14. We hope you will come too.
You'll marvel over the artisanship. This is a juried show, with world-class miniaturists vying to be among its 100 vendors. Browsing their booths, you never know what you might encounter next - a cactus garden in a tea cup, a courtier of Queen Elizabeth I, or a mouth-wateringly realistic, one-inch pepperoni pizza. Both adults and kids enjoy the activities and exhibits.
Invite a friend, treat a grandchild, make a date with your mate - or enjoy our annual fundraiser all by yourself!
Here's what you'll want to know
Some, but not all, high blood pressure or heart failure medications containing
valsartan (brand name Diovan)
have been recalled.
If one of your toes has a perpetually bent joint, making it hard to wear shoes in comfort, information on caring for
may be helpful.
The chemicals and nanoparticles in
many sunscreens harm aquatic life
, especially coral reefs. The final section of this article suggests ways to avoid causing environmental harm while protecting your skin.
A newly approved drug may be of interest if you have
endometriosis pain
. Additional details are
Bad Breath
About one in four adults have halitosis, or bad breath. Even really rank breath may not be noticeable to the person who has it. Learn when to be suspicious that
your own breath
might be unpleasant and how to check.
someone else's breath is unpleasant
, should you tell them? If so, how?
Say Goodbye to Smoking
The National Institutes of Health has lots of free resources to help smokers plan a strategy to quit, learn about nicotine replacement therapy and other treatments, and access helpful information and mobile tools.
The primary website is here
If you are a woman, senior, teen, veteran, or Spanish-speaker, you may prefer to use one of the specialized sites for those populations. You will find links to them at the top of the primary web site, either listed or available by clicking "Explore the Smokefree Family."
Dental Care
If you or a family member will have some dental work done soon, you can use Fair Health Consumer's
dental cost estimator
to learn what the procedure typically costs where you live.
A dental insurance plan might - or might not - be more cost-effective than simply paying out of pocket. Here is a very
brief overview
of issues to consider, with more
detailed information
Here are tips to help you find and choose
a new dentist
. You may also want to use your public
library's electronic resources
to access the
Consumers' Checkbook
ratings of local general and specialty dentists. If you have a personal subscription to the
Consumers' Checkbook
, the ratings are
Kids & Gender Identity
To help parents and others understand how to respond to children who express discomfort or ambivalence about the gender they were assigned at birth,
Supporting and Caring for Transgender Children
" is available from
he American Academy of Pediatrics, the American College of Osteopathic Pediatricians, and the Human Rights Campaign Foundation.
Volunteer for Fun!
Patrizia Santi
We would love to have your assistance at the Showcase for about 2 hours. Volunteers typically assist customers at the white elephant table, check tickets at the entrance, and/or monitor the exhibits. You don't need to be knowledgeable about miniatures - just friendly, prompt, and responsible.
Your admission to the show will be free and we can pay your parking fee. Please
email us
to request more information about helping on Saturday or Sunday, October 13 or 14.
A Conversation About Advance Care Planning
While it's not easy to think about what we want at the end of our lives, planning ahead can help ensure that our wishes are respected when we come to the end of our lives. To do it "our way," we also have to make sure people who might make decisions about our care know our preferences.
If you are over 55 years of age
, we invite you to a PlaneTree presentation on issues to consider when completing your advance care directive. We will also discuss how to talk about your end-of-life wishes with your loved ones and medical care providers.
Free to the public, this discussion will be
at the Senior Center
Laurel Room,
Sunnyvale Community Center
on Monday, September 17 from 9:30 to 10:30 a.m. Call 408-730-7350 to pre-register for Class #256611.AC.
All events are open to the public. Some require pre-registration.
* Fee for participation
^ Scroll down the linked page
Nutrition, exercise, stress management, & support for cancer patients, survivors, & caregivers
San Jose - various dates for a variety of programs
Exercise for patients undergoing cancer treatment
Saturdays - Mountain View
Tuesdays in Mountain View or Wednesdays in Sunnyvale
Mountain View - multiple dates in September & October
Living well with diabetes*
- 6-week class begins Fri., 9/7
Mountain View
- 2-session classes, various dates
Conference for patients & survivors of cancer or another life-altering illness, & professionals
Sacramento - Sat., 9/8
Estate planning for parents of children with special needs
San Jose - Tues., 9/11
Mountain View - Tues., 9/11
Eating healthfully on a budget
San Jose - Tues., 9/11
One-on-one appointment with a nutritionist
- Wed., 9/12
- Thurs., 9/13
Morgan Hill
- Mon., 9/17
- Mon., 9/24
- Wed., 9/26
Tai chi
Gilroy - Wed., 9/12
Suicide prevention training
Los Gatos - Wed., 9/12
Milestones of child development
Los Gatos - Thurs., 9/13
Demonstration of cooking tasty, healthful recipes for diabetes management
Palo Alto - Thurs., 9/13
Santa Clara - Thurs., 9/13
Weight management
Mountain View - 6-month program begins Fri., 9/14
Digestive health
Saratoga - Mon., 9/17
Advance care planning -
see description in preceding article
Sunnyvale - Mon., 9/17
Weight loss surgery
Mountain View - Tues., 9/18 or 10/16
Managing digestive problems during treatment for breast or ovarian cancer
Palo Alto - Tues., 9/18
Managing electronic device use in school-age kids
Palo Alto - Wed., 9/19
Lifestyle approaches to preventing heart disease & reducing cholesterol
Cupertino - Sun., 9/23
Managing high cholesterol or triglycerides
Mountain View - Mon., 9/24 or 10/22
Mindful eating
Sunnyvale - Mon., 9/24
Helping young children manage their emotions
Santa Clara - Mon., 9/24
Joint replacement & robotic technology
Los Gatos - Tues., 9/25
Teens & cannabis
Morgan Hill - Tues., 9/25
Parenting responsible, resilient kids
Saratoga - Tues., 9/25
Parenting a child with ADHD & anxiety
San Jose - Wed., 9/26
Breast & ovarian cancer
Sunnyvale - Thurs., 9/27
Living well with a chronic condition
, presented in Vietnamese
San Jose - 6-week class begins Wed., 10/3
Disability awareness & resource fair
San Jose - Thurs., 10/4
Facial paralysis
Palo Alto - Thurs., 10/4
Save the date:
Breast & ovarian cancer conference
for patients, survivors, & professionals*
Redwood Shores - Fri., 11/2
Like us on Facebook.
Please support our free health information services!
Dear Non-subscriber:
We invite you to become a subscriber
. We will never sell or share your email address, and rarely send you anything other than
s 10 issues each year.
PlaneTree Health Library is not responsible for the content on web sites accessed from our newsletter. Each originating organization has sole responsibility for its web pages.
Health and medical information accessed through our newsletter is not intended to replace or substitute for the advice or instruction of a health care professional. Please discuss the information with your health care providers.


text:
Soheil HumanSoheil Human MSc.
- Telephone:
- +43 1 31336 5198
- Email:
- firstname.lastname@example.com
- About me:
- **Homepage:** [https://nm.wu.ac.at/nm/human](https://nm.wu.ac.at/nm/human) Soheil Human has an interdisciplinary background in Artificial Intelligence, Cognitive Science, History and Philosophy of Science and Science-Technology-Society (STS). Currently, he is a research and teaching associate at the Institute for Information Systems and New Media of the Vienna University of Economics and Business (WU Wien) and a lecturer at the Department of Philosophy of the University of Vienna. He is the project lead of our FFG-funded project EXPEDiTE (EXPloring opportunities and challenges for Emerging personal DaTa Ecosystems: Empowering humans in the age of the GDPR - A Roadmap for Austria). His current research focus is on human needs & values, digital privacy, human-centric information systems and algorithmic accountability. Soheil applies a wide range of theories and methods from Philosophy, Cognitive & Information Economics, Conceptual & Computational Cognitive Modelling, Artificial Intelligence, and Semantic Web in his research. His other research interests involve digital rights, pluralism & epistemic disagreements, predictive processing, and socio-technical imaginaries.
No curriculum entries found.
Researcher Identifier
No researcher identifier found.
Awards and Honors
- 2019
- WU Award for Outstanding Reserach Achievements
- WU Award for the Acquisition of Third-Party Funding (EXPEDiTE Project)
- WU Award for the Acquisition of Third-Party Funding (OpeNeeD Project)
- 2017
- KESW2017 Best paper award for "Societal Challenges"
No classifications found.
- Cognitive Modelling
- Information Economics
- Information Business & Infonomics
- Knowledge Engineering
- Cognitive Science
- Cognitive Economics
- Artificial Intelligence
- Privacy
- Semantic Web
- Sustainable Computing
- Science and Technology Studies (STS)
- Philosophy of Science
|Position in scientific committee
|Workshop on Engineering Accountable Information Systems - Program Committee Member
|The ACM Conference on Fairness, Accountability, and Transparency (FAT* 2020) - Program Committee Member
|Position in jury, advisory board, curatorship
|since 2019
|Department of Information Systems & Operations, Vienna University of Economics and Business - Member of Department Conference
|Reviewer for an international conference
|ICIS 2019 – International Conference on Information Systems - Reviewer
|Organization scientific meeting (Conference etc.)
|MyData Conference - Session chair
|HICSS 53 - Hawaii International Conference on System Sciences - Chair (Mini-track on "End-user Empowerment in the Digital Age"))
|Organization other meeting (Excursion etc.)
|since 2019
|MyData Austria Meetups - Co-host
|Excursion to "s IT Solutions" - Organizer
|Attendance scientific meeting (Conference etc.)
|Expert Workshop on Ethical and Legal Challenges of New ICT and Security/Cybersecurity - Invited External Expert
|Other occupation
|since 2019
|MyData Hub Austria - Co-founder
Journal article
|Human, Soheil, Neumann, Gustaf, Peschl, Markus F. 2019. [How] Can Pluralist Approaches to Computational Cognitive Modeling of Human Needs and Values Save our Democracies? Intellectica. 70 165-180.
Contribution to conference proceedings
|Human, Soheil, Peschl, Markus, Bidabadi, Golnaz, Savenkov, Vadim. 2018. An Enactive Theory of Need Satisfaction. In PT-AI 2017: Philosophy and Theory of Artificial Intelligence 2017, Hrsg. Vincent C. Müller, 40-42. Leeds: Springer.
|Human, Soheil, Bidabadi, Golnaz, Savenkov, Vadim. 2018. Supporting Pluralism by Artificial Intelligence: Conceptualizing Epistemic Disagreements As Digital Artifacts. In PT-AI 2017: Philosophy and Theory of Artificial Intelligence 2017, Hrsg. Vincent C. Müller, 190-193. Leeds: Springer.
|Human, Soheil, Fahrenbach, Florian, Kragulj, Florian, Savenkov, Vadim. 2017. Ontology for Representing Human Needs. In Knowledge Engineering and Semantic Web, Hrsg. Przemysław Różewski, Christoph Lange, 195-210. Szczecin: Springer.
Paper presented at an academic conference or symposium
|Human, Soheil, Wagner, Benjamin. 2018. Is Informed Consent Enough? Considering Predictive Approaches to Privacy. CHI2018 Workshop on Exploring Individual Differences in Privacy, Montreal, Canada, 21.04.
Poster presented at an academic conference or symposium
|Human, Soheil, Bidabadi, Golnaz, Peschl, Markus. 2017. Learning to Satisfy Needs: Predictive Processing vs. Deep Learning. EUCognition, Zurich, Switzerland, 23.11.-24.11.
- 2019
- Towards Realization of Accountable Multi-modal Smart Mobility in Vienna: Do Smartphone Apps Influence Mode Choice Behavior among Viennese Citizens? The Role of User-interface Design in Influencing Users' Mobility Behaviour in Vienna (2019-2020) (Details)
- 2018
- EXPloring opportunities and challenges for Emerging personal DaTa Ecosystems: Empowering humans in the age of the GDPR (2018-2020) (Details)
- 2017
- Incentivising Open Data Exploration through Needs Management (2017-2018) (Details)


text:
We matched 9 greatest Nixeus gaming monitors over the last year. Figure out which Nixeus gaming monitors fits you best. You can also Narrow by video inputs, contrast ratio, screen size and model or settle upon one of our Nixeus gaming monitors feature picks.
For which purpose, gamingmonitors have marked the leading Nixeus attributes you can filter with foremostly: video inputs, contrast ratio, screen size, model,... and aspect ratio.


text:
In past 24 hours, Afghan National Police conducted several anti-terrorism joint operations with Afghan National Army and NDS to clear some of the areas from terrorists and enemies of peace and stability of Afghanistan.
The operations were conducted in Kabul, Laghman, Faryab, Jowzjan, Ghazni, Herat and Helmand provinces, as a result 12 armed insurgents were killed and one was wounded.
Also, during these operations, Afghan National Security Forces discovered and confiscated light and heavy rounds ammunition.
Afghan National Police encourages all citizens to report suspicious activities and criminal acts to contact by dialing 119.


text:
Languages: PHP, Java.
Databases: MySQL, SQL Server, SQL.
Other: CakePHP, WordPress, HTML, CSS, jQuery, JavaScript, Git.
Cupón Club, San Salvador, El Salvador
Won Employee of the Month Award twice: 1) January 2019 for building a modern satisfaction survey with smiley faces. 2) June 2019 for fixing push notifications for Android app by migrating from Airship to Firebase.
Redesigned mobile version of the website to a responsive format.
ESEN, La Libertad, El Salvador
Taught Introduction to Databases, Excel VBA and Programming I courses in the Department of Engineering.
Built an online classroom booking system.
Kodak Alaris, Rochester, NY
Created OLAP cubes and ETL processes for business intelligence, analytics, and reporting applications.
Developed and fixed Oracle PL/SQL scripts used to populate, data mine and generate production, service, and business reports for Remote Business Management products.
Premper, San Salvador, El Salvador
Programmed self-managed websites integrated with Content Management Systems.
University of Rochester, Rochester, NY
Teaching Assistant for CSC 261 (Database Systems).
Rochester Institute of Technology, Rochester, NY
Fulbright Foreign Student Program Scholarship (flagship U.S. Department of State's exchange program).
RIT Graduate Merit Scholarship.
Loyola University Chicago, Chicago, IL
UNICAES, Santa Ana, El Salvador
GPA 8.8/10.0 (Class rank: 1 out of a graduating class of 14).
University of Alabama in Huntsville, Huntsville, AL
Concentration in Computer Engineering.
Global UGRAD Scholarship (U.S. Department of State's exchange program).


text:
Sorry, something went wrong. Please contact support.
Over the last 4 years, I have served 100+ happy clients from the US, UK, Canada, and Australia, Switzerland, Netherlands, and Singapore. I am a master of Instagram marketing site with my excavated skill and convincing method that I have been applying for the last four years. I have a successful record as an Instagram Marketer. I'm looking for a long-term relationship with my clients and provide them with the best services. Feel free to invite me for an interview if you have a project! 🚫🚫 I Don't Use Any Software, Automation, Tools
We'll connect you two when your job is posted.


text:
It's therefore unsurprising that employers are increasingly turning to biometric authentication, or the use of an employee's physical characteristics to help identify people in the workplace.
Biometric data offers unique and attractive characteristics for employers as it is difficult and expensive to hack. So for those seeking to improve security and strengthen their attendance monitoring, technologies such as fingerprint and facial recognition are seen as something of a silver bullet.
But the use of biometrics in the workplace raises a number of thorny issues for both employers and workers alike.
Currently, workplace surveillance and privacy are governed by a patchwork of laws with some gaping holes. Protections and rights vary from state to state with overarching federal privacy principles that can be vague when it comes to employment.
In a recent case before the Fair Work Commission, the right of an employee to refuse to provide his biometric data through the scanning of fingerprints was tested.
In its initial decision, the commission found in favour of the employer upholding the employee's dismissal for refusing to provide their biometric data to be used in company-wide safety and security upgrades. Surprisingly, at first instance, this action was not found not be harsh, unjust or unreasonable and was therefore lawful under the act.
A right to appeal was upheld in the matter, and as we saw in the commission, these technologies raise a number legal issues around violation of privacy and concerns about information security. These fears are rooted in privacy concerns as well as justifiable concerns around 'function creep' – or that data recorded for one purpose in the workplace being used for another, such as law enforcement or targeted advertising.
A recent report into the use of biometric technology conducted by the UK House of Commons found that for employees, being asked to provide fingerprint or facial data by an employer feels more intrusive than giving the same information to a bank or multinational company like Apple. I suspect that this boils down to the fact that employees feel they are left with little choice in the matter if they wish to keep their jobs.
Biometrics, which has its origins in the theory of fingerprinting that emerged in the late 1880's, has only been adopted in the workplace in the past couple of decades due to significant advances in computer technology. The US was an early adopter of the technology and has had a number of high profile cases, primarily in relation to the failure to obtain employee consent or provide information on how the data collected would be stored or used.
My Health Record highlighted a number of the public concerns about privacy and data security in Australia. It seems we don't even trust our own government to keep this information secure. Even when there was an obvious benefit to participation many members of the public have chosen not to provide their private information.
Clearly when dealing with an employer-employee relationship, the situation is highly problematic because of the power imbalance that exists. Free consent is only give where there are no consequences that flow from acceptance or rejection of an offer.
So what's the solution?
There is currently no legal framework to deal with this issue that addresses the need for privacy/ the rights of employees
One solution may be to follow the European model, or what's happening in the US.
Under EU law, the General Data Protection Regulation or GDPR, provides that if an employer collects your fingerprint, they are legally obligated to secure the data and destroy it upon request when it is no longer required. This law went into effect in May 2018, and violations can result in huge fines to the violating company or organisation, up to the greater of 20 million euro or 4 per cent of their annual global operating revenue.
Section 1051 of the California Labour Code prohibits Californian employers from obtaining fingerprints or photographs of employees and sharing this information with a third party. This means that vendors providing fingerprint scanners or other technology must be prevented from accessing the biometric information. It's worth noting that in the Superior Woods matter the biometric data was stored on servers located off-site in space leased by a third party.
In a law passed in Illinois in 2008, there is a requirement that anyone collecting biometric information must comply with strict notification and consent requirements, including written pretermission. There is also the requirement that biometric data is destroyed when the purpose of collection ends and the data is securely stored.
Clearly there needs to better consistency in Australia on collection of data and workplace surveillance. But in gaining that consistency, the human rights of employees to privacy shouldn't be obliterated by going for the lowest common denominator of privacy protection. Whether that will happen remains to be seen.
Giri Sivaraman is a principal at Maurice Blackburn Lawyers.


text:
Minister Tony Clement and MP Ted Falk announce Government of Canada to bring high-speed Internet services to 4,500 homes in Provencher
LA BROQUERIE, MANITOBA--(Marketwired - May 20, 2015) -
Everyday tasks that were once done in person, such as shopping, communicating, learning and banking, are now done online. To help Canadians have better access to these and many other online services, Treasury Board President Tony Clement and Ted Falk, Member of Parliament for Provencher, were in La Broquerie, Manitoba, today to announce that approximately 4,500 homes in Provencher will soon benefit from access to high-speed Internet services.
The Government of Canada is delivering on its commitment to rural Canadians to connect an additional 280,000 households in rural and remote regions of the country to high-speed Internet at minimum speeds of five megabits per second (Mbps).
Today, the Harper Government announced it exceeded that target by over 75,000 households in the first round of partnership approvals, bringing high-speed Internet access to more than 356,000 homes across Canada at an average speed of over 5 Mbps. By Canada's 150th birthday in 2017, over 98 percent of Canadian households will be able to subscribe to new or improved high-speed Internet services, delivering on the Harper Government's commitment to Canadians.
Last summer, the Government completed the first step, inviting Canadians to provide feedback online to help better determine areas in need of high-speed Internet access. Once information was received from individual Canadians and governments across the country, Industry Canada invited Internet service providers to submit proposals for funding under Connecting Canadians to build wireless or wired infrastructure that will provide services to rural and remote communities in need.
For Canadians who live in communities with slow or no Internet, access to high-speed services will lead to new economic opportunities and the creation of new jobs, products and services.
Quick facts
"Today's announcement marks the next important phase in our government's plan to bring the benefits of high-speed Internet to communities in rural and remote regions across the country. Providing Canadians with access to high-speed Internet for learning, business opportunities and so much more is key to creating a more connected, digital Canada."
- Tony Clement, President of the Treasury Board
"Today's broadband infrastructure announcement is great news for Provencher. The Harper Government understands the importance of high-speed Internet access for communities like ours. Connecting Canadians demonstrates the Government's commitment to delivering for rural Canadians."
- Ted Falk, Member of Parliament for Provencher
Associated link
- Connecting Canadians website
Follow us on Twitter: @industrycanada
Contact Information:


text:
Learn to cut worksheets
Scholastic Teachables - browse all worksheets, resources, printables, and more for the classroom! Save hours of prep time with our online treasure trove ready-to the best free set alphabet will find! 100+ that perfect preschool kindergarten includes
Learn oracle in hindi
Akruti (™) is available in all Indian Scripts from Left to Right example connect oracle database java examples driver, drivermanager, connection, statement, resultset, preparedstatement, callablestatement.
Arabic good language learn business
Arabic Language Courses online brings best videos tutorials that show how read with understanding 21 days! easy follow.
Help to learn french numbers
For every correct answer you choose, 10 grains of rice are raised to help end world hunger through the World Food Programme take free placement test determine language skill level.
Computer free learn type
Learn to Program: The Fundamentals from University of Toronto with 10 fingers practice skills.
Learn simple english conversations
The Simple English Wikipedia is an English-language edition of the online encyclopedia, Wikipedia, primarily written in basic and special English news™ hopes what it says is.
What are the best chess openings to learn
Bringing chess to schools in Orange County, San Francisco, and Jose watch them stream magic: gathering other content live join community! online you need fight opponents world.
Learn next quiz winners only
Bebe and Gael Kakuta played in Premier League title-winning sides without earning a medal - can you name the others their squads? Learn Hardware Security from University of Maryland, College Park get latest science news technology news, read tech reviews
Can learn ontario login microsoft
The Ontario branch of the Canadian Physiotherapy Association, OPA is a professional organization whose mission to provide leadership, support and advocacy for its public / students.
Game learn to write numbers printouts
FROM: Roosh check out this great letter practice activity concise, well worded letters that set correctly.