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Joint inquiry into Northern Ireland's welfare policy launched
12 April 2019
The Northern Ireland Affairs Committee and the Work and Pensions Committee have launched joint inquiry to examine the impact of welfare policy in NI, with a focus on policies such as Universal Credit and the two-child limit.
The Committee is inviting written evidence on the following questions:
- What has been the impact of the NI Executive social security 'mitigation package'?
- What would be the likely effects of the mitigation package coming to an end in 2020?
- What, if anything, should replace the mitigation package from 2020?
- What are the effects of having higher levels of welfare entitlement in Northern Ireland? Is it feasible for Northern Ireland to have differing levels of welfare entitlement in the long term?
- How well is Universal Credit working in Northern Ireland? Are there issues with Universal Credit that are specific to Northern Ireland compared to the rest of the UK?
- Do people in Northern Ireland benefit from the flexibility to have Universal Credit paid at a different frequency or with split payments?
- What is the impact of the two-child limit on families in Northern Ireland?
- Do social housing tenants in Northern Ireland (including NIHE tenants) regularly experience rent arrears? What are the reasons for this? What level of deductions do tenants face to pay back arrears?
The closing date for submissions is Friday 24 May 2019.


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They/them/theirs - A monthly non-binary discussion
Jo and Rayne are non-binary and once a month they sit down and talk about what that means. We're here, we're queer, let's talk about it.
At around 45:20 into this episode we talk about our experiences with a transphobic slur and concept, so heads up! This month we sit down and bounce between topics and conversations about media that gave us questions about ourselves early on, and other formative...
#3: Presentation, Experimenting with Fashion, and Queer-Made Clothing
Together this month, but not actually, we discuss existing outside of our usual safer spaces, Carlito the Raccoon, binding, presentation, choosing clothes, navigating dysphoria and experimentation, and queer owned clothing brands. Links for things we discuss/recommend...
#2: Dingos Crossed
This month we sit down to bounce between several topics, including gender comics, SonicFox, finding the right pronoun for you, the fear of "deciding" vs experimenting and fluidity, Jablinski, metaphors, cowboys, and Nintendo's naming conventions. You know, the usual....
#1: A Charcuterie of Gender
In our inaugural episode, we sit down and talk a little about our history with gender and being non-binary, what it's like explaining being non-binary and coming out, dysphoria, finding ourselves in media, our favorite vines, and cats. Our theme music is Big Trucks by...
What people are saying…
"I have asked friends to listen to this with me bc I am just so bad at explaining my gender. After listening to it she would look at me at the line about the mix and match body parts and asked if I feel like that. I obviously said often times yeah. The hosts do great and provide such a relaxing and fun way to talk about gender. Thank you guys."
– Dukeofdork
"I love this podcast so much. As a fairly closeted non-binary person, this is extremely relatable for me. You've put things into words that I've had a hard time explaining. This is honestly making a big difference in my life, and helping me cope with dysphoria and prejudice. The majority of my family doesn't support trans people, or even believe that Non-binary identities exist, but your podcast has created a community for me, so thank you so much for making this, and please continue because it's really making a difference in my life. 🏳🌈🏳🌈🏳🌈🏳🌈🏳🌈❤🧡💛💚💙💜"
– ships lams
"Rayne and Jo seem to have so much fun together and I like that they each have different non-binary perspectives to come from (sexuality, workplace, family). I'm looking forward to hearing more banter that I can chew on as I figure out my identity."
– Flummoxy
SHow details
+ Cast & Credits
Show Cast:
Jo: @ghostofjo
Rayne: @smallsmallwitch
Theme music: "Big Trucks" by I Believe in Julio

subset: commoncrawl


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The tremendous results of the Small 8" Sprocket have echoed its brother, the large sprocket, as our finest tournament performer. Best as a long rigger lure, the Small Sprocket displays a tight swimming action successful in calm seas to a light chop.
The Small 8" Sprocket in Stripy combination features a Purple Inaz outer skirt. This lure skirt has a fluro purple back highlighted with black inaz stripes. The underbelly of the skirt is clear fluro purple and the entire lure skirt is layered with silver glitter and enhanced with UV Optical brighteners.
The inner skirt is Dark Purple Blue. This lure skirt has a dark purple back with fluro blue coloured underbelly. This lure skirt is coated with silver glitter all over, and enhanced with UV Optical brighteners.
The Stripy combination is complemented by a purple tinted head.


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As the auction sale of the Miami Marlins nears its expected end, at least one bidding group feels bogged down in disorganization — with no clear deadlines or process, sources said on Monday.
The sale, being run by team owner Jeffrey Loria and team president David Samson, was originally thought to be aimed at picking a winner by the July 11 All-Star Game. But that date has come and gone — with three bidding groups still in the running.
"There is no process," said a source close to the situation. "The truth is, it is chaos."
A Derek Jeter-led bidding group is said to have offered $1.2 billion for the money-losing team, while Jorge Mas, a Miami billionaire, has bid slightly less. A third group, led by Tagg Romney, son of Mitt Romney, is also in the running, sources said.
Loria is seeking $1.3 billion.
"[Loria] won't make a decision," the source said. "Everyone is dancing and no one is committing."
Typically, teams use a bank to vet bids, but in this case, there is no bank or adviser. The Proskauer Rose law firm, which works closely with Major League Baseball, appears to be the main point of contact for the parties.
A Major League Baseball spokesman declined comment.
One group in the process said Samson was angling for a job under a new regime. When asked about such talk on Monday, Samson said, "Check your sources."
Loria, a New York art dealer, bought the team for $158 million in 2002. Forbes in April estimated the franchise was worth $940 million.


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Ready for another great day at Lewa. We started with our circuit training session outside overlooking the savannah of Northern Kenya. It's a healthy beginning to our morning and in keeping with our message of prevention of Chronic Disease.
After our breakfast we take our short ride to the clinic breathing in the fresh air and smells of nature. We arrive to the big smile of Rosaline (of course) as well as patients who are already waiting at the clinic for the afternoon clinic hours with the Naweza doctors.
But before we see the patients, we have a full morning of presentations by our doctors as well as Benard, the lead on our Kenyan research studies.
The topics included were:
- Benard – Findings from the CVD Program
- Kristen – Type 1 Diabetes
- Dr. Tanya – Diabetes and Hypertension Review + Post CVD Event Care
Benard gave an excellent summary of our CVD program study so far. The study will provide proof-of-concept that a community health worker, equipped with a novel "mHealth" technology on her cell phone, can screen for hypertension and diabetes in the community setting. Non-communicable diseases are increasing in importance globally, and these "silent killers" contribute to cardiovascular disease (heart attack and stroke) which are now overtaking infectious diseases as the leading causes of death. Our study is an innovative strategy for active case-finding in a rural setting, in order to identify patients in need of lifestyle and pharmacologic interventions to reduce the risk of cardiovascular disease. By subjecting our program to the scrutiny of a scientific study, we are applying a high level of rigour to our clinical activities, and we will be able to report our findings to the scientific community for potential scalability.
Dr. Tanya's discussion was quite interactive, with several questions and references to cases that the nurses encounter at the clinic. They also had the opportunity to get up in front of their own peers and work through different scenarios of potential CVD patients. They needed to determine, based on certain data, which risk categories to put those patients into. Depending on the category, the patient will have a different treatment strategy. It was a good exercise not only to give the nurses a chance to demonstrate to their co-workers their own knowledge, but also was a stepping off point for a robust discussion on the nuances of cardiovascular disease cases and how you might navigate a particularly tricky scenario.
We were told that there has recently been a big increase in cases of malaria. Usually in a month's time the clinic will see about 10 cases, but last month alone brought in 44 cases. This is mainly caused by the above average rainfall that the area has received. Good news for the animals and vegetation, but it doesn't come without a cost. The stagnant water attracts the mosquitos and is where they like to breed. Fortunately the clinic has access to point of care diagnostics and can quickly determine if a patient presenting with a fever and other flu like symptoms has malaria, and if positive, commence immediate treatment with anti-malaria meds.
After a quick lunch, the team headed back to the clinic to see patients. Dr. Michael worked alongside one of the nurses providing training on the IMCI (Integrated Management of Childhood Illness) algorithm. This is an algorithm that can assist on when to give and withhold antibiotics. A child came in presenting with cough and cold symptoms and they were able to use the tool to determine that the patient did not in fact need antibiotics. Antibiotic stewardship, as well as managing the limited resources available to the clinic, are the ultimate goals. The nurses are too often inclined to give antibiotics to the patients when in fact it is unnecessary. This is mainly due to their uncertainty in the diagnosis and fear that they may get it wrong. The IMCI tool will hopefully give them confidence that they are in fact making the right decision and providing good care for their community.
One case in particular involved 2 young HIV+ boys. Unfortunately the boys had begun late on the antiretroviral agents (ARTs) and as well were not fully compliant on the drugs. By not taking the ARTs on a regular basis, their immune systems were compromised, resulting in warts developing on their face. Dr. Michael reinforced the importance of staying on the drugs in order to halt the progression of the warts and/or any other potential conditions caused by a depressed immune system.
Dr. Tanya worked with the nurse, Hagai. They saw several interesting patients including one woman who complained of knee pain when she squatted. Dr. Tanya thought it sounded like a condition called patella-femoral which normally would require a knee brace to help keep the knee cap in line. The interesting thing was the woman designed her own make-shift brace with a piece of gauze which she claimed made the pain subside, a design which Dr. Tanya thought actually resembled the brace you would normally get in Canada. The fact that she was able to intuitively put this together is sort of incredible if you think about it. But these are the kind of survival strategies that the community must employ in order to manage their health. Despite having access to the clinic, the woman's ability to afford such a brace is limited. And the clinic's access to such a brace is unlikely. So Tanya advised her to continue to wear the "brace" and teaches her how to do exercises that will help strengthen the area.
That's it for now. Looking forward to another day of training and seeing patients tomorrow!
Thanks for reading!
Stacy ☺


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It is extremely possible that you have seen origami and not realized exactly what it had been. Today, origami as a hobby is perfect for all ages and has come through generations from many other art types. Origami is the Japanese term for folding paper along with ORI meaning to collapse and KAMI meaning papers. Together the two form 'origami'.
People realized that origami is really a perfect hobby for children since it taught hand/eye coordination along with a sense of concentration. It is really an art form that has been passed on through parents to children via generations. Many children understand origami as a hobby while in college and some children even carry on this craft into their mature lives.
Origami involves making forms only by foldable paper. Birds, fish, sock puppets, shapes, toys, animals, as well as masks are just some of the versions that can be learned in just 1 sitting. An origami item can greatly vary in dimensions and design; from a folded away box to small and sensitive creatures. This practice is extremely easy to learn and most individuals find it an enjoyable pastime. Origami folding guidebooks, along with unique paper, are now available in numerous stores for purchase. These publications demonstrate the basic folds associated with origami and also introduce several shapes.
Most origami items use just one uncut sq . piece of paper.You can use origami document bought in a shop you might as well cut a squarefrom a regular piece of paper. When flip-style the paper for origami, it isimportant to remember to fold because exact as you can; make sharp folds bytaking your hand down along the crease to really make it flat. The instructionswith regard to origami contain symbols which represent exactly how to createthe actual folds. Origami instruction ebooks have keys in them that willexplain the symbols. There might be a slight variation from one guide to another but basically, there is certainly one set of standard symbols for many instructions. Once you are familiar and comfy with basic folds and also symbols, you will successfully have the ability to complete all types of box parts.
The more accurate and accurate your folds on within piece,the better the completed project will turn out. With regard to best results,work on a set, hard surface. When you first find a fold, do it loosely in the beginning and make sure all corners along with edges are lined up precisely.Once the paper is arranged exactly right, hold the report tight at the fold in addition to move your fingers within the paper towards the line till the fold is formed. The actual fold crisper, run your own nail down the edge of the flip you have made.


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47 Essex Court #A
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Screw Holder - Holds Non-Magnetic Screws Tight
The Screw Holder is a transparent rubber sleeve that slides onto screwdrivers to hold a variety of screw sizes to the end of a screwdriver. You will never drop a screw again!
Photos of Prototype
The ribbed head interior keeps screws straight while the interior taper adjusts for a wide variety of screw head sizes.
The ribbed shaft interior was designed to have constant contact with the drivers shank, the 4 points of contact allow for a wider range of shank diameters. It also reduces friction while sliding the holder up or down the shank.
The solution to always having your Screw Holder handy is to easily store one on every screwdriver in your set and simply slide it into position when you need to use it.
How it works
Usage is simple. Take your screwdriver and slide the sleeve onto the end of the shank. The interior is tapered, so simply adjust the depth to fit the screw head size. Next, insert the screw head into the Holder.
Due to the interior taper, it is an easy adjustment for larger screws too. Slide the sleeve back on the shank of the screwdriver and insert the larger screw. Slide the Holder about three-fourths of the way onto the shank. The slits in the Holder accommodate a wide variety of screw head sizes. You will note that there are ridges in the material of the Holder to keep the screws from shaking out.
We will be producing the Screw Holder in two sizes. We have measured every screwdriver that we could find and I even purchased a 64 driver set from Craftsman and we found that with these two sizes of Screw Holder we were able to fit the widest range of common screwdrivers and screws.
The above diagram details out which shank diameters will work with which size Screw Holder. The four internal linear ribs were designed to make contact with different shank shapes so it easily works with hex and slot drivers.
These are the sizes and shapes that we can confidently say work the best when we tested the Screw Holder. This range covers nearly all standard size screws found in the household or construction site.
Testing our Screw Holder on a Class 10 off-road buggy with our custom made dashboard hula girl.
With the Screw Holder the versatility is a great feature whether you are working with stainless steel screws on your boat, assembling inexpensive furniture with non-magnetic screws, or working on your computer. The Screw Holder is your partner to make these processes run as smoothly as possible.
We are very proud to be producing the Screw Holder in the USA using recycled materials. The manufacturer we have chosen to work with produces high quality products for companies like Snap-on Tools. They are local which was important to me so I can work closely with them to ensure that we produced the best tool possible.
For our domestic buyers shipping is included. After lengthy research and discussions with our fulfillment center we have determined that we are only able to offer international shipping for our $22 & $40 reward tiers. Thank you for your understanding and we appreciate your interest in our project.
The above production schedule is something we have worked very hard to put together. We have read the Kickstarter horror stories with production and fulfillment and we believe we have partnered with the correct people and companies to make this project run as smoothly as possible.
These guys are great! We will be using Fulfillrite for all our packing and fulfillment. We wanted to make sure that our rewards ship on time to our backers.
Screw Holder is on
Facebook - YouTube
About Me
Hi, I'm Phillip Kauffman, an LA based designer and innovator. I grew up working with my dad in his custom cabinet shop where I developed my love for working with my hands. Then, during college, I started my own business airbrushing custom cars, motorcycles, and sailboats. I did that for six years while finishing my degree. By a chance meeting in an airport, I fell into designing movie posters and television campaigns.
Enough about me, let's talk about my product. I designed the SCREW HOLDER to eliminate my frustration with screws falling off the end of my screwdriver when I'm assembling something new or fixing something that has broken. My ultimate goal is to always streamline my process. With the SCREW HOLDER I have made my life easier and now hopefully it can help you too.
About the Team
Brett Kauffman - Brett is working on finishing his Mechanical Engineering degree at Cal Poly Pomona. He has refined my design and developed all 7 of our prototypes with his expert lathe work. Could not have gotten this far without him!
Dan Ucko - Dan is a social media guru, his in-depth knowledge of all things trending will help lead our campaign's Twitter and Facebook pages.
Daniela Kauffman - My wonderful wife, Daniela, is extremely detail oriented and will be running our accounting and fielding customer service inquiries when we reach that point.
Eddie Chai - Eddie is an extremely talented videographer and designer working with him on our video was an absolute pleasure. I would highly recommend him! His website is Saltytiers.com
Jason Gearlds - My lawyer extraordinaire. Jason is a huge part of my team advising me on all things legal pertaining to business and trademarks. Wouldn't have been able to do it without him.
Where do pledge funds go?
Our $18K goal will go directly to manufacturing the first production mold it also includes the cost of order fulfillment. If we exceed our funding goal we will be able to purchase a mold with more cavities. Any additional funds will be used to scale the business and hopefully get our product into retail markets.
Risks and challenges
We have sourced a local manufacturer here in Southern California so we are able to meticulously watch over every step of the manufacturing. After successful funding we will be able to pay for the full production mold which will take 8-10 weeks to machine. Once the mold is completed, manufacturing and packaging the parts will take another week. Then we will then deliver them to our fulfillment center and the first 2500 units will be shipped within approximately two weeks. Any orders above that will be shipped in order of when they were received the project.
I have an amazing network of people who run their own businesses manufacturing and shipping products all over the world and I have every confidence that with their continued help we will be able to make this product a success!Learn about accountability on Kickstarter
Funding period
- (30 days)


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I need to exchange Azerbaijani manats in Hyderabad, India. Where can I do it?
closed as unclear what you're asking by Tor-Einar Jarnbjo, Revetahw, Andrew Lazarus, Gayot Fow, Some wandering yeti Sep 4 '16 at 6:41
Please clarify your specific problem or add additional details to highlight exactly what you need. As it's currently written, it's hard to tell exactly what you're asking. See the How to Ask page for help clarifying this question. If this question can be reworded to fit the rules in the help center, please edit the question.
Why not take dollars to Azerbaijan or use your card? – JonathanReez♦ Aug 28 '16 at 20:19
2Possible duplicate of When traveling to a country with a different currency, how should you take your money? – JonathanReez♦ Aug 28 '16 at 20:19
5Suresh, are you trying to change rupees into manats before travelling from India to Azerbaijan, or trying to change manats into rupees after travelling from Azerbaijan to India? (or maybe do you just have a bunch of Manats somehow and you need to change them while in Hyderabad?) – user568458 Aug 28 '16 at 22:45
You can't - you'll have to exchange them for euros or dollars in India and then change them in Azerbaijan or Georgia
3It's also possible that OP has Azerbaijani currency which they wish to exchange for Indian rupees. – Revetahw Aug 28 '16 at 21:39


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WANTED: Hospitality / Customer Service RepresentativeRecruitLynnwood, WA, USA
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Seize the opportunity
5G will bring disruption to the status quo. By 2022, total mobile data traffic will exceed 70 ExaBytes per month, equivalent to a single person streaming HD video for 3.5 million years. 5G will also carve out new avenues for business growth for operators large and small. Ericsson research shows that operators could capture an additional 34 percent revenue, or approximately USD 582 billion, from 5G-enabled market opportunities by 2026.
This new era will open the way for organizations to move into new markets and build new revenue streams with radically new business models and use cases.


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Sciatica Relief
Tips for Managing Sciatica Pain
Sciatica is a painful condition caused by pressure on the sciatic nerve, which extends from the lower part of your back down through your hips and legs. A herniated disc in the lumbar spine is the most common cause of sciatica pain, though bone spurs can also cause symptoms. Most sciatica pain will resolve on its own within six weeks, but depending on the nature of the injury, it could persist for longer periods of time. In such cases, most patients require pain management strategies, as sciatica pain can be debilitating at times.
Symptoms of sciatica include:
- Radiating pain, originating in your lower back
- Numbness, tingling and/or muscle weakness in the affected leg
- Worsened pain when seated
Most patients experience pain in only one leg. In severe cases, urinary or fecal incontinence may also occur.
Managing Sciatica Pain
As mentioned, most cases of sciatica clear up with conservative forms of treatment in a few weeks. However, since those few weeks can be very painful, you are likely to be offered a number of options for managing the pain, including:
- Prescription medications. Depending on the severity of the pain, your doctor may prescribe a painkiller to help ease your symptoms. Anti-inflammatory drugs will be the most likely choice if your doctor believes your pain is being caused by inflamed tissues along the sciatic nerve pathway. Other choices include narcotic painkillers, including opioid analgesics, as well as muscle relaxants and anti-seizure medications, which are known to help nerve pain. Complex cases of sciatica may respond best to anti-depressants, which help the brain produce more of your body's natural "feel-good" chemicals, thus reducing your pain.
- Steroids. Corticosteroid injections may be used to provide immediate relief if your pain is severe. These medications work by quickly counteracting inflammation in the tissues surrounding your sciatic nerve, providing rapid relief. This relief is usually temporary, and you can only get a limited number of steroid injections before this will no longer be a viable option, as corticosteroids can cause serious side effects with prolonged use.
- Physical therapy. Improving your kinetics is the key to defeating sciatica pain once and for all, and physical therapists can show you exercises that will strengthen your back and techniques for better, safer movement. Ideally, the combined effect will be to speed the healing of your current sciatica pain and prevent additional episodes from recurring in the future.
- Surgery. This is a last resort for sciatica pain management, and will only be explored if your symptoms have been severe and persist beyond the six-week mark. Surgical interventions are very effective at addressing the root cause of your sciatica pain, but back surgery comes with an inherent risk of potentially serious complications. Your doctor will not recommend surgery unless you have exhausted all other options without finding relief.
Alternative Treatments for Sciatica Pain
If you want to try a holistic method for your sciatica pain, either as an alternative to conventional medicine or as a supplementary treatment, many patients report that acupuncture and chiropractic medicine can provide relief. However, scientific evidence supporting the efficacy of these treatments is inconclusive, and there is no guarantee they will work. Even so, there is a large body of anecdotal evidence which suggests they can be very effective and provide immediate and lasting relief.
More Sciatica Management Strategies
There are things you can do at home to help ease your sciatica pain until the problem resolves itself. Gentle stretching exercises that target your lower back can loosen up tense muscles and provide some relief. Hot packs and cold packs can also be used to bring down pain and irritation. Alternating hot and cold packs for 20 minutes several times per day can calm down acute cases of sciatica pain. If severe pain remains for an extended period of time, make an appointment with your doctor to discuss your symptoms.
How to Assess Pain
Doctors will often use the McGill pain questionnaire in order to tell how a patient is feeling.
read more / Assessing Pain


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Mother's Day at Stones of the Yarra Valley
Sunday May 12, 2019
What better way to celebrate Mother's Day than within the beautiful surrounds of Stones of the Yarra Valley.
With views across 200 acres of vines to the Great Dividing Range, The Barn is Stones of the Yarra Valley's superb main dining room.
This Mother's Day, The Barn will present a 'La Famiglia' Shared Feast where an array of exquisite sharing dishes and whole roasted meats take centre stage. Feast on a series of canapés, followed by three shared entrees, two shared mains accompanied by two sides and a delightful array of petit four desserts to finish.
Open for lunch from 12.00pm
We're also open for Mother's Day lunch at our sister restaurant, The Stables at Stones.
To make a reservation, please contact our team on
(03) 8727 3000 | email@example.com
Mother's Day Menu
King prawns, feuille de brick, babaganoush, pomegranate, petite herb
Caramelised pork belly, soubise, apple, mustard fruit crumb
Wandin quail, Sichuan pepper, asian slaw, green chilli yoghurt
Sher Wagyu rump 7+, crisp semolina, smoked aioli, jus
Petuna ocean trout, walnut tarator, pea tendril, radish
Dobson potato, confit garlic, herbs, sumac
Panzanella salad, charred red peppers, croutons, lemon vinaigrette
A series of petit four desserts to finish
$85 per adult
We also offer a three course children's menu priced at $50 per child (strictly 12 years and under).
As the availability of our local produce changes throughout the season, the menu above is subject to changes.
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Department of Surgery
School of Medicine > Surgery > Faculty > Shahid Umar, PhD
Shahid Umar, PhD
Professor of Surgery
Vice Chair of Research
Research in my laboratory is focused on the role of bacterial infection in colonic crypt hyperplasia and/or inflammation and/or cancer. Specific research areas include: (a) Regulation of cross-talk between components of the Wnt/b-catenin and Notch and NF-kB and Notch pathways in relation to complex inter-relationship amongst cell proliferation, inflammation and cancer; (b) Cancer Stem Cells, and (c) mechanism(s) of chemoprevention by dietary factors and its novel derivatives.
The bacteria or microbiota present on the mucosal lining of our GI tract perform critical functions needed for proper metabolism and immune surveillance. For example, bacteria ferment undigested carbohydrates into short-chain fatty acids (SCFAs) that function as an energy source and control epithelial cell growth and differentiation. However, alterations in the microbiome, through changes such as infection or diet, can disturb this symbiotic relationship and promote cancer.
Notch signaling plays a critical role in maintaining progenitor/stem cell population as well as a balance between cell proliferation, differentiation and apoptosis. Upregulation of Notch signaling is also reported during inflammatory bowel disease (IBD). The Wnt signaling pathway also plays a crucial role during development of tissues and organisms. Wnt signaling cascades cross-talk with Notch signaling pathways to constitute the stem cell signaling network. Dysregulation of this network due to epigenetic and genetic alterations may lead to congenital abnormality and carcinogenesis.
What is less clear however is how the cross-talk between the two pathways is regulated in native epithelia and whether the pathogenic insult affects the cross-talk itself to trigger the disease process. Increased rates of proliferation form the earliest and most probably, the necessary background for the transformation of a normal colonic epithelium to cancer. A direct link between inflammation and cancer has also been established with NF-kB emerging as a key player. Recently, dysregulation of microRNAs has been observed in patients with ulcerative colitis. However, little is known about the functional consequence of dysregulation of miRNAs during chronic colitis in epithelial cells, and even less on tumorigenesis. We utilize an in vivo model of bacterial infection-induced hyperplasia of colonic crypts to study these complex pathways in real-time.
Using a Citrobacter rodentium model of bacterial infection, my lab has shown that Citrobacter can promote colon crypt hyperplasia and tumorigenesis by aberrantly regulating Wnt/β-catenin and Notch signaling pathways (Figure 1). We have further demonstrated that Citrobacter causes elevated expression of the histone methyltransferase EZH2 in infected colon crypts and tumors. EZH2 catalyzes transcriptional repression of E-cadherin to promote epithelial-mesenchymal-transition (EMT) to occur. Whether these changes further promote metastasis and/or frank malignancy is currently being investigated.
See More Information on Research and Publications for Dr. Umar


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BELGRADE (Sputnik), Victoria Mladenovich — On Sunday, The Times reported, citing German government sources, that a certain bill for NATO defense was handed over to Merkel during private talks with Trump in Washington on March 17.
"The reports about the mentioned invoice or bill are wrong. Chancellor Merkel and President Trump discussed the topic of defense expenditure during their talks in Washington. They informed the public about these talks in a press conference," the government spokesperson said.
On March 18, following the meeting with Merkel, Trump wrote on Twitter that Germany owed "vast sums of money" to NATO. On Friday, German Defense Minister Ursula von der Leyen criticized the US leader for his controversial remark stressing that "there is no debt account in the Alliance."
The target of spending two percent of the GDP mandated by NATO was adopted at the Alliance's September 2014 Summit in Wales, with only five countries, including the United States, meeting the required standard, according to NATO figures.
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Weekend Review: Trump's Culture of Violence and Startup Comeuppance
Welcome to the weekend, the knockoff play days that bookend responsibility. (How I wish this were true.) Amber is away for the weekend, and I'm flying in-solo-parentis for a couple of days. I suspect the boys and I will clean the garage, shoot some hoops, perhaps build a fort in the muddy woods. Maybe we'll catch a movie, grab some pizza and root bear. I'll find a book before the day is over. Maybe we'll shoot a bottle rocket.
Life is a mix of responsibility and frivolity; isn't it?
But before I get my weekend started, I offer you this skinny-minute respite. Grab a cup of joe and catch up on some of the week's happenings. Fair warning: for those of you not politically inclined, or those of you who like Donald J. Trump, consider skipping the first segment in this week's review.
Last night, Chicago canceled Donald Trump's rally scheduled for 6:00 pm at the Chicago Pavillon. Fearing the mass of protestors who'd gathered to voice their displeasure with Trump's antics, the city did the right thing, nixed the event. Perhaps you've not taken note, but Trump's rallies have become increasingly violent over the last several weeks. How did we get here?
But despite his harsh rhetoric and violent overtones, did you know that Donald J. Trump is the only 2016 Presidential candidate to be nominated for this year's Nobel Peace Prize? These are the things that boggle the mind. I'm not political scientist, but this is insane.
Perhaps you work in a cool, post-industrial, neo-cubicular creative space with hammocks and slides. Maybe you have a ball pit in your office, or a trampoline. Good for you. But do you have a Pac-Man themed conference space? In this hilarious piece, Fast Company gives cheesy startup office design their comeuppance.
John Ray--friend, godfather to my sons, and cycler extraordinaire--writes a weekly column on bike commuting in the Ozarks. I think you'll enjoy his words, especially this piece on his attempts to outrun grief.
I visited Charleston, South Carolina last weekend. There, I say this perfectly normal reindeer playing a hang drum.
In my Recovery Room series, Heather Caliri offered her confession, wrote about using the Bible as an instrument of self-harm. This piece is weighty, sobering, and necessary. Please don't miss it.
Thanks for reading along. I hope to see you next week. Until then, check out this piece by Noah Gunderson and David Ramirez. Enjoy.
Thanks for stopping in! If you enjoy reading here, sign up to receive my bi-monthly Tiny Letter. If you sign up, you'll receive my free eBook, Coming Clean|Austin Outtakes. The Outtakes share the story behind my latest release from Zondervan, Coming Clean|A Story of Faith.


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Hiking Trail · Freiburg Area
Vom Schwarzsee auf die Kaiseregg
12.9 km
755 m
4:45 h
1200 m
by Jochen Ihle,
Wandermagazin SCHWEIZ
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The leggy model looked like she walked straight off the set of Saturday Night Fever in a tiny spangled sliver dress that exposed not only her cleavage, but flashed a lot of thigh.
The scandalously dress was cut right down to her belly button- but luckily a panel of sheer beaded mesh protected Georgia from spilling out.
The stunning frock was covered in metallic fringe and beading, which the rock and roll heiress paired with black stilettos.
And Georgia didn't stop with her outfit. The 21-year-old went full-on with her curly backcombed hair, clipped back with a string of tiny diamonds, and a dramatic sweep of bright green eyeshadow.
Anyone else messing with the bold shade would have looked like they had been rooting around their mum's make-up kit, but the stunning fashionista worked it.
While her technicolor make-up may have been a bit much for popping round to Tesco, it definitely suited the occasion. Rimmel model Georgia was attending the brand's star-studded 180 Years of Cool bash in Covent Garden.
The willowy babe, famed for her gapped teeth, rocked up to the glittering event in classic London style- in a Rimmel black cab.
And Georgia wasn't the only Rimmel cover girl partying at the uber-cool soiree. Kate Moss and newbie Rita Ora were seen posing with Georgia as they all fought for the most stylish London look.
We reckon Miss Jagger has that prize tied up.


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Read More
First impressions are critical, and at the foundation of it all is the house.
At the heart of many Greek houses is an elegant dining room. Read our blog on how making this room a beautiful centerpiece creates a valuable key element in your house design.Read More
Great planning and great partners can mean that the additions made to your chapter house
can look like they were always built that way!


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Album cover photos of : DEEP PURPLE - Mark I and II 2LP Gatefold
|Back Cover Photo of "DEEP PURPLE - Mark I and II 2LP Gatefold" Album
|Note: the above pictures are photos of the actual album and allow you to judge the quality of cover. Slight differences in color may exist due to the use of the camera's flash. The quality of these images has been reduced in order to preserve network bandwidth, high quality images of these scans can be made available on request
Collectors information & Description:
Gatefold (FOC) cover design with artwork / photos on the inside cover pages
|Music Genre:
|70s Classic Rock British
|Record Label:
|Purple Records 1C 188-94 865
|Record Format:
12" Double Vinyl Stereo Gramophone Record
Total Album (Cover+Record) weight: 480 gram
|Country of Origin:
|1973 Made in Germany


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Good old JavaScript has long been associated with the ghetto, to a certain extent. It was born in 10 days under severe management pressure and it took another decade for the language to gain well-deserved recognition. It was initially supposed to be easy. In order to draw the attention of professional developers, its syntax was made similar to Java, but this solution didn't bring any positive results. Professionals didn't want to rush into this, not with the way things were, and newbies, stuck on the rosy notion, didn't deliberate much upon code's quality. As a result, the language became a second-rate tool for building clumsy things, hardly sufficient to vivify pages of that time.
Those, who used to be accustomed to deal with other programming languages, complained about confusing syntax, unpredictable work of some operators, endless troubles with weak typing, problems with the scope of variables and a bunch of other defects.
So, jQuery demonstrated, that JavaScript is capable of a lot, and stirred developers to use it. Change of attitude to the language made it evolve, and new technologies, such as Node.JS, turned JavaScript into much more than just a scripting language. Nowadays, it can take over all the stages of creating a web application (both front- and back-end) without resorting to additional tools.
Finally, Angular is the next step in JS evolution made by Google. Its rampant growth of popularity, recorded by BuiltWith, proves, that Angular has earned the trust of leading companies. So as to back up this affirmation with evidence, let's take a closer look at 7 of Angular's most remarkable features.
Finally, Angular is the next step in JS evolution made by Google. Its rampant growth of popularity, recorded by BuiltWith, proves, that Angular has earned the trust of leading companies. So as to back up this affirmation with evidence, let's take a closer look at 7 of Angular's most remarkable features.
1. It's perfect for SPA development
Angular is a JavaScript framework that embodies peculiar carcass for application development, SPA (single page applications) particularly. At first glance, such applications are not different from regular web pages. What makes them special then? When we receive a message, reply and go through friends' newsfeed without refreshing a page, then we certainly deal with an app built with Angular or some other JS framework. Gmail is such an app, for instance.
Considering Angular our main tool to build an app with, we get several benefits that will make our work easier. Among the advantages of Angular for start-ups and companies are quick coding, rapid testing of any part of an app and data binding (changes in back-end impact on user's interface immediately). Since the release of the first Angular, it's ecosystem has evolved far beyond imagination. Thus, it's rightfully called the most used JS framework for SPA development.
2. It's not demanding
Angular has quite a low entry threshold relative to plenty of similar solutions. It contains a compelling documentation provided with examples. Tutorial trials (e.g. TodoMVC Project), great presentations and numerous screencasts make it even more appealing to beginners. If a developer has never dealt with frameworks like Angular though, basic knowledge of JavaScript and TypeScript may come in handy.
Angular is an open-source product, which is essential for developers, for they can slide straight to coding, evading license and special equipment costs.
3. It's progressive
The first release of Angular was in 2009, and several versions of the product have come out since then. Starting with the version 2.0 Angular became cross-platform, prioritizing mobile apps. Much more attention was given to touch-events and gestures, available on all devices. Every performance testing, conducted by Angular team, can be found in the public domain on GitHub, so that anyone can take a look or even run them again. Speaking of performance, Meteor team ran a performance competition among front-end developers. In the end, Angular 2 won, leaving React behind.
Another important feature of Angular 2 and newer versions of the product is their compatibility. Projects made with the version 2 can be easily imported to 4, 5 etc. However, it isn't compatible with AngularJS. Thus, Code & Pepper team strongly recommends using Angular 2 or newer versions rather than AngularJS.
4. Declarative approach
Unlike other libraries and frameworks, Angular doesn't consider HTML a problem, that needs to be taken care of. It concentrates on what must be achieved, not how to achieve it. Declarative style saves us from the need to write thorough instructions and only describes the result we want to get. Finally, we get a concise and easy-to-read code. Here's a simple demonstration of such a code on jsFiddle.
5. It's organized
Writing a clear programming code in the times of AngularJS was quite a challenge. A lot of guidelines showed up back then, which led to misinterpretation on the Internet. The Angular Team learned the lesson well and provided Angular 2 with a style guide in order to help users organize the code, making it more readable and less mistake prone.
6. 2-way data binding
Angular offers a concept of data binding always centered on the scope. Only objects inside the scope can be bound together.
Angular unites codes into one integral system, so you neither have to update HTML manually nor inspect elements as if you're using jQuery.
1. It's customizable
Angular is fully integrated with Angular Material – a user-friendly design system that offers customization tools for app's components. Changing themes, color palettes or typography configuration has never been easier.
Rockstar Games – an American video game publisher, well-known for action-adventure games, such as Grand Theft Auto and Max Payne and franchises. The website is built with Angular 2.3.0:
Teradata is an open-source UI platform. Angular 5.1.0 and design solutions of Angular Material were used to create this project:
Youtube TV. YouTube is available on a large number of devices and offers Live TV from 40+ networks. Its app is written with help of Angular 2.4.8:
Cloud Player is an alternative SoundCloud player built with Angular:
VNware Open Source Software. They are developers of open source projects and they used Angular 4.3.6:
Citibank Customer Service app is another example of Angular's potential (v4.3.0):
Freelancer.com – the name says it all. They use Angular 5.1.0 on their homepage:
Ng2 Finance – a finance dashboard using Yahoo's public APIs:
The top sites mentioned above demonstrate Angular's versatility. Judging from our experience, Angular has proven itself to be an efficient tool in FinTech area, and we tend to use it more often. Our recent project – an app for Helvetia Swiss Insurance Company that enables individuals to buy insurance policies – wouldn't have shown up without it.
No doubt, this JS framework is a high-quality solution Google surprised us with.
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There are safety features in the auto world out there, but then there's the Subaru EyeSight suite, which is second to none in terms of driver assistance aids. Offered with most new Subaru models, the EyeSight suite bundles safety options like lane change assist, automatic cruise control and blind-spot monitoring, among others. Press play to learn what one expert has to say about the EyeSight suite, then visit our Springfield, IL Subaru dealership serving Decatur, Taylorville, Jacksonville and Chatham today to get started.
While similar kinds of safety features in other makes and models can activate when not really needed, or even surprise you in a dangerous way, the Subaru EyeSight features deliver warnings in a clear, but unalarming, way. These features are designed to keep you out of harm's way, but even if you find yourself getting into an accident you can't avoid, your new Outback, Forester, Legacy or Impreza is designed to keep you and all your passengers safe.
Learn more about the EyeSight suite by coming over to Green Subaru today.


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It takes dedication to turn out to be a chef. There isn't any storage for provides and paintings for neighborhood artists. Martin declared his purpose was to re-set up the College of Arts as a neighborhood cultural centre, and also to determine a everlasting reside theatre in Sutherland Shire. By the 1930s, with the pound for pound subsidy provided by the NSW Authorities withdrawn during the Great Despair, Schools of Arts have been dissolving or being taken over by local councils as a consequence of declining membership and funds.
For years, I've heard glowing evaluations from colleagues, lecturers, artists and friends about Arrowmont School of Arts and Crafts and for years I've dreamily combed over the course catalog. In Cronulla, the College of Arts crammed an necessary role, offering a social area open to each women and men, free of alcohol and offering night amusements.
The Dynamic Math Membership led the first Math Consciousness Day of Western Cagayan College of Arts and Trades with the theme Unleashing the MathinikTradeans" on November 23, 2012. Official opening of new Cronulla Faculty of Arts building, reported in the Sydney Morning Herald on Thursday 24 April 1913, p. four. School of Arts social occasions including these in help of the building fund".
One of the crucial vital art and design faculty requirements is the portfolio. The Wagga College of Arts building in Fitzmaurice Avenue has undergone quite a few changes over 150 years. By 1969 the Cronulla School of Arts had six associated organisations which all used the premises.
Although the Düsseldorf School was part of the German Romantic Motion, with time nevertheless, it advanced from Romantic-Poetic styles to the Neoclassicist ones. Over the past 60 years, the supply of theatre has consolidated the College of Arts' central role in Wagga's cultural life.
If the goal is to increase pupil efficiency on the standardized exams, then let's encourage the directors at California schools to use all of the sources at their disposal to assist the students to perform well. Pinkney requested a number of questions, and provided antidotes, advised artists to check, and worked passionately and carefully to assist each scholar in one way or one other.


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Lxxx, Cereal Killer and 6 Guests are viewing this topic.
Hes got 3/4 games before I make a decision on it I want him to stay or go.In his defence, he stated all window he wanted a CB. He wasnt given one. Left with 2 defenders who cant play together. Same with the Rom issue aswell. Since he went, season after season managers have said we needed a replacement and it never came. I know its very mush a grasp at straws but I honestly dont think theres many who can come in and sort this team.
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Sexual Atheism: Christian Dating Data Reveals a Deeper Spiritual Malaise. Sexual Atheism: Christian Dating Data Reveals a Deeper Spiritual Malaise. By Kenny Luck, Special to CP | Thursday, April 10, 2014. Facebook Twitter Email Print Whatsapp Menu Whatsapp Google Reddit Digg Stumbleupon Linkedin Comment.
2/26/2015 · Recently, a girl emailed Paula Hendricks, a writer for the Lies Young Women Believe website, and asked her whether it was OK to date, love, and marry an atheist. Hendricks, a Christian
Looking for an online dating site with a large Christian user base? Christian Dating Sites Atheist Dating Service is just one of several sites that make up the Online Connections dating network. That means if you create a profile on Atheist Dating Service, it'll appear on all of its sister niche sites — saving you money as well as time
1/10/2013 · The lady is a Christian but her daughter is married to an atheist, If I remember correctly she was living with her daughter and son-in-law. Anyway one day at dinner the lady decided to pray grace
Atheist Christian Women In Africa - Christian Dating Look through the profiles of Female members here at Christian Dating Africa that are associated with Atheist. Talking to other members that have similar interests is a great way to come up with ideas to do on a first date.
1/8/2014 · What's an atheist to do when he or she is dating someone from a religious family? This is an expanded answer to a question I responded to in a recent edition of my series, You Had to Ask.
Atheist Dating is part of the Online Connections dating network, which includes many other general and atheist dating sites. As a member of Atheist Dating, your profile will automatically be shown on related atheist dating sites or to related users in the Online Connections network at no additional charge.
"I'm falling in love with an atheist" she explained. The man she's falling for just happens to be her dance partner, causing her to interact with him several times a week. I´d like to share that when I became a Christian 8 years ago, I had been dating an atheist guy for 3 years. I loved him! I wanted him to trust Christ, of course
Radiometric dating; i'm a christian dating a christian. Simple and has subsided there who was the essay, but your match maker - ellen degeneres dating christian perspective, j. Seriously dating,. ?. Because there. It is american; christian dating systems date anyone was an atheist superficially, 2009.
Christian Dating Atheist - If you are trying to find girlfriend or boyfriend, sign up on this dating site. You can meet interesting people and maybe fall in love. A person can do a simple search online to read on their goals to set up the site.
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Atheist Dating Service - Start chatting with beautiful and interesting people right now. There are single girls online looking for single men in Tokyo free dating sites. Many local Christian singles groups do not do any marketing, advertising or promotion and depend on word of mouth by singles or church members to recruit new members.
Atheist Christian Men In Africa - Christian Dating Browse profiles of Male members that have joined Christian Dating Africa that are associated with Atheist. Talking to other singles who have like minded interests is an ideal way to find things to do once you are dating.
Atheist Online Dating . Free online Christian dating is readily available to Christians who are looking for friends or life partners. women in maine women wife beaters questions for dating. Being able to trust your partner understand you and enjoy your company is essential to establish a strong relationship with them.
Atheist and Christian dating - relationship lesson (self.Christianity) submitted 5 years ago by sparkie_t First of all - thanks to /r/Christianity I learnt a lot about my ex-girlfriends point of view by searching this subreddit prior to our break up.
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Christian dating an atheist i find it interesting that they even found your post and took the time to answer.So christian dating an atheist if they are atheist, why are they lgbt wedding expo 2017 houston reading christian dating an agnostic the christian mom blog?.
Atheist Guys - Christian Dating - Ireland Look through the profiles of Male singles here at Christian Singles Ireland that are tagged with Atheist. Dating other singles who have like minded interests is a pefect way to find things to do on a first date.
7/28/2013 · Christian dating an Atheist? Discussion in 'Christian Advice' started by andrew8806, Apr 26, 2011. Apr 26, 2011 #1. andrew8806 Senior Member. 14 +2 Non-Denom She states that she is atheist and she knows im a Christian and how important it is to me. Click to expand She may be a wonderful lady; however, she does not share your faith. At all.
7/3/2017 · CHRISTIAN CRINGE!! Christian VS Atheist Men - Dating Preferences. This is a response to a video titled "How Christian Guys Describe a Godly Girl".


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Good morning
This message has helped me realize that time with God no matter what is important. When I'm home my kids too also disrupt me as soon as I am ready to spend time with God or the phone ring etc. I learned to spend time in prayer or worship every morning on my day to work and from work. My commute is a bit long. Thank God for this message. Pray my strength in the lord. Amen!
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