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CLCA1 encodes a member of the calcium sensitive chloride conductance protein family. Additionally we are shipping Chloride Channel Accessory 1 Antibodies (61) and Chloride Channel Accessory 1 Kits (5) and many more products for this protein.
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Results suggest that CLCA1 is involved in intestinal mucus homeostasis by facilitating processing and removal of mucus to prevent stagnation.
CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway
Increase in TMEM16A activity occurred within minutes of exposure to CLCA1 or after a short treatment with nocodazole, consistent with the hypothesis that CLCA1 stabilizes TMEM16A at the cell surface by preventing its internalization.
Data show that calcium-activated chloride channel regulator 1 (CLCA1) and transmembrane protein 16A (TMEM16A) co-localize and physically interact and that CLCA1 increases the level of TMEM16A protein at the cell surface.
inhibitor and siRNA transfection studies demonstrated an apparent effect of CLCA1 on ovarian cancer cell aggregation
Results confirmed that the low expression of CLCA1 in CRC was associated with tumorigenesis, early metastasis, and high chromosomal instability. Low expression of CLCA1 predicts recurrence and lower survival.
These findings demonstrate the ability of hCLCA1 to function as a signaling molecule and activate macrophages, central regulators of airway inflammation.
CLCA1 may contribute to promoting spontaneous differentiation and reducing proliferation of Caco-2 cells.
CLCA1 expression is significantly related to mucus production in the airway epithelia of smokers and COPD patients, and may contribute to the development and pathogenesis of COPD by inducing mucus production.
These data provide both a mechanistic basis for CLCA1 self-cleavage and a novel mechanism for regulation of chloride channel activity specific to the mucosal interface.
Increased expression of hCLCA1 in allergic rhinitis was correlated with the expression of MUC5AC.
in cultured nasal airway cells, Th2 type cytokines increased hCLCA1 (calcium-activated chloride channel 1) expression in Cystic Fibrosis patients but not mucus expression
The 357SS genotype was significantly overrepresented in both patients with meconium ileus and also with a severe CFTR genotype (P = 0.009) and in p.F508del homozygotes (P = 0.002).
upregulation in the IL-9- responsive mucus-producing epithelium of asthmatic subjects supports the hypothesis that this channel may be responsible, in part, for the overproduction of mucus in asthmatic subjects
transfection of Caco-2 human colon carcinoma cell line with pCLCA1 to investigate the regulation of CLCA-associated chloride conductance in this differentiated epithelial cell line
hCLCA1 expression in NCI-H292 cells specifically induces soluble gel-forming mucin production. This Ca2+-activated Cl- channel plays an important role in epithelial-regulated inflammatory responses, including goblet cell metaplasia.
polymorphisms in chronic obstructive pulmonary disease
Variation of the CLCA1 gene affects patients' susceptibility for childhood and adult asthma in a Japanese population.
CLCA1 and CLCA4 may have roles as modulators of the gastrointestinal basic defect in cystic fibrosis
conclude that hCLCA1 and mCLCA3 are non-integral membrane proteins and therefore cannot be chloride channels in their own right
These data implicate CLCA1 in the expression of eqMUC5AC in horses; and suggest regulation by CLCA1 and epidermal growth factor receptor between horses with recurrent airway obstruction and those with milder degrees of inflammation.
In this study, eCLCA1 protein and mRNA expression were quantified in airway goblet cells of horses with RAO and controls using immunohistochemistry and laser microdissection followed by RT-PCR, respectively.
pCLCA1 shares essential characteristics of hCLCA1, supporting the pig model as a promising tool for studying the modulating role of pCLCA1 in the complex pathology of cystic fibrosis.
pCLCA1 expression may increase the sensitivity of preexisting endogenous Cl(-) channels to Ca(2+) and cAMP agonists but apparently lacks inherent Cl(-) channel activity under growth conditions where endogenous channels are not expressed
The data underscore and specify the role of mouse CLCA1 in inflammatory airway disease to activate airway macrophages.
These findings demonstrate that 10.1.1 Ab rapidly and specifically induces proliferation and growth of Lymph Node lymphatic sinuses and stroma, suggesting a key role of mCLCA1 in coordinating Lymph Node remodeling during immune responses.
Clca1 is not required for mucus synthesis, structure and barrier function in the murine colon.
mCLCA3 appears to modulate leukocyte response via IL-17 and murine CXCL-8 homologs in acute Staphylococcus aureus pneumonia which is well in line with the proposed function of hCLCA1 as a signaling molecule acting on alveolar macrophages.
Findings suggest that increased expression of a single-gene, mCLCA3, could simulate an asthma attack, and its mechanism may involve mCLCA3 overexpression up-regulating IL-13 expression.
PA-LPS-induced MUC5AC and Clca3 expression is partly through Duox1
these findings argue against a role of mCLCA3 in Ca(2 )-activated Cl(-) channel-mediated Cl(-) secretion in murine respiratory epithelia
Here, we have characterized the cleavage and autoproteolytic activity of the murine model protein mCLCA3
Mclca3 mRNA was positively expressed in airway epithelium of asthmatic murine models with airway inflammationbut but was negatively expressed in control group. negatively expressed in control group (Figure 2).
a functional link between two distinct anion currents, ClC-3 and swelling-activated chloride current
Niflumic acid treatment during natural antigen-exposure, where mCLCA3 is greatly up-regulated in the lung, significantly reduces airway inflammation, goblet cell metaplasia and mucus overproduction in vivo.
Gob-5 expression is not essential for mucin overproduction in vitro or in murine models of allergic asthma
We found that mClCA3 expression was significantly decreased in the colon and lung of the cftr-/- mice.
demonstrated accumulation of mucus and increased mClca3 protein in the bronchiolar epithelium of asbestos-exposed mice at all time points but peaking at 9 days
These observations reinforce findings that associate Gob-5 with goblet cell hyperplasia and mucus production in the allergic immune response, but also implicate Gob-5 in the regulation of tissue inflammation in the innate immune response.
Primary 110-kDa translation product in the endoplasmic reticulum cleaves into a 75-kDa amino-terminal and a 35-kDa carboxyl-terminal protein that are glycosylated and remain physically associated with each other but cannot form a channel on their own.
ClC-3 is not detectable on large dense-core vesicles of endocrine cells, but localizes to endosomes and synaptic-like microvesicles in both adrenal chromaffin and pancreatic beta cells.
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.
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Quinoa is all the rage right now, so we decided to check it out! It started out as trying to create a yummy side dish, but it turned out so well, we could've had it as a main meal. Our Simple Veggie Quinoa is quick and unbelievably yummy!
I used to be "scared" of quinoa (or rather, just unwilling to try it), thinking it was a "pretentious" ingredient and possibly carby and unhealthy. This week though, I did some research and it turns out, quinoa is technically not a grain, but a seed. It is also considered a "complete" protein as it contains all the essential amino acids. Very cool! Not as bad as I initially thought.
I won't recommend adding quinoa to your daily menu, because it does have a high carb content. It's way healthier than any other grain (rice, etc) and is the best choice if you crave something "grainy" like this occasionally.
What I love most about our little quinoa recipe is the fact that it's a one pot thing. Toss all the ingredients in and leave it until all the water is soaked up. Quick and easy recipes are my favorite.
After 5 minutes of dicing and about 15 minutes of cooking, you're left with a fluffy bowl of quinoa. If making this recipe is your first time making quinoa, I need to warn you: You're going to fall in love with it. Sorry in advance.
Simple Veggie Quinoa – Pin it!
- 1 cup • quinoa rinsed
- 2 cups • vegetable broth
- 1 • celery stalk diced small
- 1 • carrot diced small
- 1 • small onion diced small
- 1 tsp • dried thyme
- to taste • salt/pepper
- Toss everything into a pot and bring to the boil.
- Turn down heat and simmer for about 15 minutes, until all the liquid is soaked up and you see the little white string around each little quinoa seed.
- Serve up this beautiful little dish with a sprinkle of scallions!
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"I adored this book from across a store and bought it before I even opened it (thus judging by the cover)! As I read it I wanted to simultaneously sing, dance and grab a box of pencil crayons and start to do my own art. My granddaughter and I looked up Wade Hemsworth online and learned about this iconic songwriter. I confess to having been sadly ignorant about his wonderful output. Now we can belt out the lyrics with gay abandon."
Fran, Vancouver
"My name is Claire and I am 4 3/4 years old. My mom sings me the Log Driver's Waltz every night at least once. We really like it so much. We live in Toronto (in Cabbagetown). I like the pictures that you made in your book. My favourite picture is the log driver. Where do you live? Well, I have to go bed now. I hope that you keep making books. Good night!
Claire, Toronto
"…each illustration looks subtly well loved, like it has been folded up and carried around in a pocket all day. The colour palette is snug and homey, with rusty oranges, black-ish greens, and tinges of pink when love starts to bloom. Most images bring to mind a crisp fall day during magic hour… Phelan steps lightly, but decisively, in interpreting The Log Driver's Waltz, preserving the song's inherent birl without overshadowing the agency and decision-making power of a girl."
Quill & Quire


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Bit Depth 21 - Cory
Hello, and again, welcome to Bit Depth. I'm Santiago Ramones.
Through band or Sable or something, I know Cory. Regardless, we got reacquainted via Terry and he contacted me to try to get on the podcast. I really enjoyed podcasting with him. Unfortunately, our second hour from that session wasn't recorded, so that conversation is forever lost to the void. However, there's many more where that one came from, even though I was pretty excited about it. Anyways, here's this one, which was really good, too. There's a website he mentioned that he contributes to: https://spioenkop.blogspot.com/


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Sign Making Companies in New York
Comprehensive list of New York based companies, dealers and shops offering sign making, manufacturing, installation and repair services.
Popular Cities
- Astoria
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- Freeport
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Business Listings
Sign Me Up Signs and Advertising Solutions. Long Islands Premiere Sign shop. Specializing in all phases of general Advertising. Custom Signs, Channel Letters, Printing, Banners, Carved Signs, Full Digital Graphics, Vehicle Graphics, Vinyl Wrap & Websites.
- Creative and gets the job done! Cleaned up afterwards and did amazing work. Responded
New York City Signs and Awnings is a premier sign and awning designer, manufacturer, and installer operating in and around NYC. Our company works with a variety of industries including restaurant, medical, office, hotel, apartments, condos, small and large businesses and commercial properties. Our graphics team can create custom signage and awnings that will reflect your brand, graphics, lettering,
- Awesome job guys. I really did not expect the sign for my business to be so attractive.
Custom Sign Fabrication "to the Trade" for NY area shops
Allstate Sign & Plaque manufactures and sells traffic signs, parking signs, and safety products. We offer fast shipping and customization of almost all products.
- Whenever we need something, it is easy to find, easy to order and is delivered ASAP!
We offer creation professional signs, banners, websites, printing, car wraps, trailer wraps, yard signs, graphic design. One of the best advertsing dollars you can spend is on lettering up your company truck or trailer. Signs, Car Wraps, Custom Team Apparel, Website, Printing, Trailer Graphics, Banner and more. Tell us what you want and we can assemble a custom package with modern graphics and brand
FASTSIGNS� brings you a wide variety of products and services, including virtually all types of signs, graphics and exhibits. We also serve as your central access point to the sign industry's most powerful resources. Whatever kind of sign you need, from a single banner to a series of sign installations in dozens of locations across the country, FASTSIGNS� is your single source.
At Eagle Master Signs, our aim has been to ensure the complete satisfaction of every client, while providing friendly and knowledgeable service at reasonable prices. Our hope is that you will feel confident in our capability to suit all of your expectations and know that our clients are always our number one priority.
As one of the Northeast's largest custom sign shops we specialize in sign design, manufacturing, installation and maintenance. From the initial site survey and permitting to routine service attention every step of the way we have the professionals to take care of your project.
- Great sign at my office thanks to Saxton sign. I am very happy! On time and quality work!
All our signs are custom designed and manufactured right here in our sign shop. We work with you on style, wording, and your needs to get you the best sign for your needs. We do truck lettering, temporary signage, neon fabrication in house, neon repairs, boat lettering, banners, and any computer vinyl cutting. The art of glass bending to make neon signs is a fascinating aspect of sign making. John
Creating Signs, Business
- Very creative, amazing design work she puts the time into every job
New York City, New York. We produce custom signs and wide format prints for almost all applications. We work for many industries including architectural, retail, office, restaurant, art galleries, and artists. We work for many national companies including Whole Foods Market. We are a focused local shop as well producing quality work professionally installed in Midtown, Downtown, Uptown, the Upper West
Edge Signs & Awnings is a Full Service Sign, Awning & Advertising Company. We offer a variety of signage, promotional products and services that will help your business stand out. Whether you need signs, awnings, banners or just basic printing, we can provide the "EDGE" you need. No Fancy Showroom or Expensive Location; We come directly to you so there's no wasted time. We Are An Aggressive And Personal
- Recently purchased a house with outdoor uncovered porch space and decided to place a retractable
Digital Ink Arts is a diverse company, founded in 2000 by D.J. Button. Our company has sold logos to business world wide! Through years of experience Digital Ink has extended their services to Signs, Vinyl Graphics, Screen print and Photography. Our company is a one stop design shop! With us you can count on good, fast and reliable service. Please explore our website to learn more about our services
We take great pride in our craft of developing compelling visual images in the form of signage, vehicle graphics, billboards, logos and more. Our goal is to create signs that captivate people and draw them to your business or organization. We offer many sign and graphics products, as well as custom logo design, sign servicing, installation and maintenance. We are conveniently located between Mount
Fisher Signs & Shirts is conveniently located at 1691 County Rd 39 on the corner of 39 and Shrubland Rd in Southampton opposite Mt. Fuji Restaurant, just as the highway starts heading East. We have many years of experience serving the Hamptons and understand how to provide eye catching, effective, classy signs at a reasonable price. We are well versed in town code and can assist in obtaining sign permits.
We provide custom builds signs, banners, decals and displays for store fronts, events, schools, churches and any other place a strong image is needed to convey the power of your business name. We ensure your image is conveyed appropriately. Your business regardless of size needs to make a lasting impression with signage. Each sign we produce will meet your criteria it must meet our manufacturing and
Overview: We are a complete service sign firm situated in West Seneca NY. We are pleased to be the biggest neon manufacturer in upstate NY. On site, we currently have 2 full time journey man glassbenders pumping out miles of neon for our many clients. What we do: Over the past decade we currently have branched out to provide more than neon signs. We have a comprehensive fabrication shop and CNC and
Premier Sign and Awning Systems Corp. is a leader in Upstate NY supplying our clients, both huge and tiny, with the best quality signage and service. We are dedicated to forming a life long partnership with our clients as well as our suppliers. Come visit our office and manufacturing facility situated in the Holleder Technology Park.
San Signs and Awnings was founded over sixteen years ago in a 500 square foot basement space and has since developed into the Tri-State area's premier sign firm with a production and office facility of over 33,000 square feet. Since its inception, our firm has never drifted from its aim of giving exceptional service while delivering a quality product at a realistic and reasonable price.
Since 1950, our aim has been to ensure the complete satisfaction of every client, while providing friendly and knowledgeable service. We know that you have a choice of sign firms in the area, and we evaluate your consideration. Our hope is that you will feel confident in our capability to suit all of your expectations and know that our clients are always our number one focus.


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Previously Owned 2013 Swift Bordeaux 38' x 12' Three Bed Holiday Home
Located on plot 1236
£ Finance Available
A short walk from coastal footpaths, this Swift Bordeaux is the perfect holiday for families and those looking for a base to explore the surrounding areas
Enjoy a life of discovery in this Swift Bordeaux located on our Bay View Holiday Park. Three bedrooms makes this holiday home perfect for families, especially if you are looking to explore Morecambe Bay and the surrounding areas. A spacious plot featuring 2 decks and views of the rolling country hills also makes this holiday home the perfect retreat to relax and unwind.
The 2013 Swift Bordeaux includes:
- Living area with electric fireplace and coffee table,
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- Double bedroom with ensuite,
- Two twin bedrooms,
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- Spacious plot and patio doors to the front of the holiday home,
- Wardens on-call 24/7.
Find out more about ownership at Holgates by giving us a call on 01524 701508


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Challenge #1/
A fellow designer for TSBM set us a challenge based on Ali Edward's new book about using patterned paper more effectively in scrapbook designs. Check out the challenge on Annie's blog - you can get there by clicking on the link on the left. There will also be links to other people's designs on there too. This is my first page for the challenge using 6 scraps of patterned paper and 3 photos. It sums up my whole experience of pregnancy both times in that it just wasn't what I was expecting (also a good pun don't ya think?)Journalling says: 'swollen ankles...heartburn...sore back...sleepless nights...support belts...physiotherapy appointments...pelvic pain...special exercises... Obviously I forgot to mention the palpitations, the hives, the lack of clothing choices!!
Annie - I hope this doesn't bode ill for you!
Can't wait for the next challenge. My stash is ready and waiting!!


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Staff Directory
The following is an alphabetical directory of the Orange Hunt ES staff. Type in a staff member's last name and select Search for quick results. Or you can search by department or job title. For example, to find all of the teachers, you can type "Teacher" and select Search.
|Pallotto, Jennifer
|School Counselor, MS
|Parker, Kelly
|Resource Teacher, ES
|Patrick, Brenda
|Grades 4-6 Teacher, ES
|Perez Rauda, Darling
|Custodian II
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|Prentice, Ann
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The stars of the latest Hollywood female epic moive, "Snow Flower and the Secret Fan," Li Bingbing and Gianna Jun shoot a batch of photos for Trendshealth magazine to promote their film.[Photo: sina.com]
What are the core ingredients to a classic Chinese film? The answer is as enigmatic as the question – but if one were to pick a modern example, it might be "Snow Flower and the Secret Fan".
"Snow Flower"'s behind-the-scenes story is as quintessentially Chinese as its actual plot. Produced by Wendy Deng (whose husband Rupert Murdoch happens to be a major media mogul) from the bestselling 2005 novel by Lisa See, the film was initially due to headline Chinese tabloid favorite Zhang Ziyi.
However, Zhang is said to have fallen foul of Deng for some reason, leading to her replacement, Li Bingbing.
The film itself is about ancient, exotic concepts of Chinese fidelity and love: Laotong (the friendship of two women for life), foot binding and nüshu ("women's writing," a system of written characters used historically among Chinese females in some remote regions), elements making it a contender for serious critical consideration.
Directed by well-known Chinese-American Wayne Wang ("Chinese Box" (1997)), the film focuses on two girls who form a laotong relationship and how their relationship stays true throughout life's hardships.
With South Korean actress Gianna Jun (in Korean Jeon Ji-hyun) playing the other lead, a Chinese-born female producer, and Florence Sloan (Malaysian-Chinese wife of MGM CEO Harry Sloan) co-producer, the film is an all-Oriental women's team.
"I work with almost all women this time and the film is also about women. It's a girls' team," director Wang said during the 2011 Shanghai International Film Festival early this month.
Set over three different periods – early 20th century rural Hunan, and 1990s and modern-day Shanghai – and switching between the three, the lead characters share much of the same personality and intimacy, although their outfits and environment vary. The language and dialects in the film are also various, including the Hunan dialect (as once spoken by Mao Zedong), Shanghainese, Putonghua, English and Korean.
In terms of the content, you may have guessed already but the producers firmly deny it: There is no lesbian undercurrent, according to the makers.
Li insists, "Laotong is no lesbian, it is too vulgar to say so!" as she told media.
| The 2nd Sino-French Film Festival to Open in May
| Xu Qing in the Movie "To My Wife"
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Cleaned up stunning BC Roman silver coin sent for ID
As it turns out, there are very few trigas (3-horse hitch) on Roman coins of any type – only a few among the Republicans which run heavily to quads- and bi-gas. It's C. Naevius Balbus, 79 B.C.
This is specifically the only type of serrate denarius with a triga reverse.
Also, the "SC" on the obverse is quite unusual as well, indicating that the silver for the issue was approved – probably as a huge emergency issue to raise and equip an army during the civil war disturbances at the time of Sulla's dictatorship – by a specific act of the Senate. Not particularly early, and definitely not rare, but in the Republican silver series, it is a unique combination of all of these somewhat lesser-seen elements: serrate, triga, "SC". The "CCV" on the reverse is a control mark and variable.


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ORLANDO, Fla. — The component that helped lead to Rafer Alston's exit from the Houston Rockets has become his elixir with the Orlando Magic. What did not work with one team now works with another, and that club is now making everyone take notice.
In Houston, Alston was criticized for not delivering the basketball to Yao Ming, the behemoth center, beneath the basket. Dealt midseason to Orlando after an injury to the Magic's All-Star point guard Jameer Nelson, Alston found a comfort zone and a big man to his liking in Dwight Howard.
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Alston's transformation explains part of the Magic's startling success, but hardly all of it. It is a team with pieces from everywhere — Alston from Houston, Hedo Turkoglu from the Sacramento Kings and the San Antonio Spurs, Rashard Lewis from the Seattle SuperSonics — that has been efficiently fastened together, with Howard as the centerpiece. Viewed as no more than a prop for the Cavaliers on Cleveland's presumed march to the N.B.A. finals, the Magic is instead on the verge of making the finals itself, for the first time since 1995.
Only eight teams in N.B.A. history have rallied from a 3-1 deficit, the daunting odds that the once heavily favored Cavaliers now face. The Phoenix Suns were the last team to do so, wiping out that margin against the Los Angeles Lakers in the first round of the 2006 playoffs.Continue reading the main story
But to do what the Suns did, the Cavaliers must find help for LeBron James on offense and deal more effectively with the problems the Magic creates for the Cavaliers' defense.
Typically, an Orlando play begins with the 6-foot-8 Turkoglu, whose height creates instant mismatches as he brings the ball to the frontcourt from his point-forward slot. When Cleveland tries to trap him to disrupt Orlando's pick and roll, and also keep Howard under wraps so that Turkoglu cannot dump the ball to him, the Magic deftly moves to Plan B: 3-pointers from other players who are left open. Exhibit No. 1 is the franchise-record 17 3-pointers the Magic made Tuesday.
And when the Magic starts connecting on 3s, the Cleveland defense becomes reluctant to rotate from its perimeter assignments, leaving Howard in single coverage beneath the rim. This, in turn, usually leads to a dunk.
Indeed, the Magic offense, if firing on all cylinders, is impressive to witness, especially when Alston's shot is on. He delivered 26 points in Game 4 and made six 3-pointers.
Alston's production underlined the multiple challenges the Cavaliers have been facing. Whenever they appear to have one hole plugged — as was the case Tuesday when Lewis was often bottled up — someone else, like Alston, breaks free.
"It seemed like they wanted to go small," Lewis said of the Cavaliers' defensive approach in Game 4. "LeBron was guarding me. They wouldn't leave me on the wing. Even when Anderson Varejao was guarding me, every pick and roll we ran, the guy would stay home on me, so it was hard for me to get a shot off."
But, Lewis added, the Cavaliers were leaving Alston open, "and he was coming up big and knocking down shots."
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The TNT analyst Charles Barkley, on Tuesday's telecast, said that Cavaliers Coach Mike Brown deserved some scrutiny for the way he has allocated playing time. "If I'm on the Cavaliers, I have to question Mike Brown at some point," he said. "In one game, he plays Pavlovic. In the next, he doesn't play him. In the next game, he doesn't play Szczerbiak and he doesn't play Gibson. He puts those guys in a very awkward situation."
Earlier in the series, James and the outspoken Mo Williams clamored for more single-teaming on defense and said individual defenders should be held accountable for their own man. Varejao and Zydrunas Ilgauskas were not among the players championing that option because they are the two Cavaliers entrusted with defending Howard.
If they do end up having to guard Howard one on one, they will probably be highlight reels on the Magic's path to the finals. Then again, what else can the Cavaliers do to plug their holes?Continue reading the main story


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Gay rumours eclipse Condi's glory moment
IT SHOULD have been Condoleezza Rice's finest hour as US secretary of state: at last President George W Bush was hosting a Middle East peace conference that she had been struggling to organise for months.
Yet when Rice's photograph appeared on the front page of America's bestselling weekly newspaper last week, it had nothing to do with her peacemaking efforts. She had been dragged into a National Enquirer article headlined "Who's Gay and Who's Not".
The article revived long-standing Washington gossip about Rice's sexuality and sparked off the usual flurry of internet chatter about her high-profile role in a Republican administration widely regarded as hostile to gays.
It also underlined the increasing friction in American politics between a high-minded media establishment disdainful of bedroom gossip…


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Do you work for Reynolds and Reynolds? Claim your page now!
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Pros: Integrates well with our other platforms. Easy to use.
Cons: Every morning I will check the leads and the ones I get over night won't tell us what car they are looking for. It will just have their name and number which is fine- but we need more data so we can be prepared. If i need to close out the lead, I have to wait five minutes and refresh before it will work. After lunch it will work better- but still not quickly. There is just so much lag
Pros: We have been using them forever and it's a pretty good product.
Cons: Wish it was able to do more. It's a little outdated.
Pros: What a great CRM! Customer support is good.
Pros: I love the contact management tool. Helps us with contacting our customers. Our DMS is seamless with our CRM and that makes it nice.
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Cons: It breaks down a lot for how expensive it is. Every time they come out with an update it seems like something else breaks.
Pros: Really like them - things are going good
Pros: Loves how everything works and how easy it is to use.
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Learn tips and tricks for finding the right vendor products for your store.


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I'll admit it. When I woke up in the middle of the night last week to a flurry of notifications that Bitcoin had surged 23%, to over $5,000, in a matter of an hour, I was skeptical.
I scanned Twitter. The first thing I saw was a tweet from the CEO of one of the world's largest crypto exchanges, Binance, proclaiming himself "honestly clueless." CZ, who was arguably in the best position to know what was going on, asked his followers, "Anyone know any news?"
The next thing I noticed: An account, @BTCWonderland, noting that there was a "rumour spreading on Chinese social media" that "the SEC is going to pass Bitcoin ETF."
In that tweet, which featured a screenshot of a WeChat discussion (translated by my colleague Lucinda Shen), someone named Aaron says, "Just received the newest reliable news. The U.S. SEC has just approved a Bitcoin ETF [clapping face emojis]…Last month I just added more leverage to buy up BTC (victory signs). This is freaking perfect timing."
I did another search, and quickly came across a tweet of an obviously fake screenshot impersonating the official account of the U.S. Securities and Exchange Commission. "Our Office of Compliance and Examinations has approved one of two Bitcoin ETF applications," the fake tweet read—as if the SEC actually tweeted clickbait-style blind items (click to find out which one it approved!). Similar fake tweets were showing up on Facebook.
I checked the time. It was still April Fool's day on the West Coast—though in China, where rumors were apparently spreading, it was well into the afternoon of April 2nd. Was it possible this rally was just the result of a joke, lost in translation? There was even an actual joke article spreading quickly across social media, headlined, "SEC Drops the Bomb: Approves Bitcoin ETFs." Although the article was labeled as a joke, that didn't stop some international blogs from picking it up as news.
Of course, if Bitcoin buyers were bidding up the price based on a misunderstanding, then the price should just as quickly deflate. That didn't happen. While Bitcoin initially gave back some of its gains, it's currently bouncing up again, topping $5,300 earlier today and now hovering just below that level. That's more than $1,000 above where Bitcoin traded last Monday.
And still, no one can really put their finger on what's driving this rally. Chris Burniske, a partner at the venture capital firm Placeholder whose book Cryptoassets applies economic principles to cryptocurrency, told me he had "little insight beyond massive buys in Asia" on the first night in April, which may have set off a chain reaction. Reuters reported there was a $100 million Bitcoin order that came in overnight. Other analysts read meaning into technical thresholds the Bitcoin price had surpassed, which might convince some investors to buy. Some observed that Google searches for Bitcoin had spiked around the same time—but it wasn't clear if the searches were just a reaction to the rally itself, with people looking for a cause of the surge.
In the meantime, several top investors seem to be waiting and watching to see if this rally is the real deal before buying in. For now, Lewis Fellas, chief investment officer of Bletchley Park Asset Management, a U.K.-based crypto hedge fund, says he's "also skeptical." If this does turn out to be a sustained leg up in the Bitcoin price, it could mean the joke's on us, the skeptics who sat on the sidelines. But for the many who bought into the last big rally in late 2017, only to lose their investments last year, some caution might pay off.
We're now just a little more than two months out from Fortune's inaugural Brainstorm Finance conference in Montauk, N.Y., which The Ledger team is co-chairing. Our stellar lineup just keeps growing, and now includes CEOs including Circle's Jeremy Allaire, Mastercard's Ajay Banga, Western Union's Hikmet Ersek, Clovyr's Amber Baldet, and many more. You can apply to attend here, or join us via the livestream in June.
Send feedback and tips to email@example.com, find us on Twitter @FortuneLedger or email/DM me directly at the contact info below. Please tell your friends to subscribe.
In precisely five days, the September fiat settled bitcoin futures contract at CME expires.Yes, another month is nearly over, so… Read More
The "Big Four" auditing firm, Deloitte's Luxembourg unit is working on letting its employees pay for lunch using cryptocurrency, especially… Read More
Patrick Byrne , the former chief executive of Overstock.com who sent shockwaves through the blockchain community not too long ago… Read More
Bit Farms, a cryptocurrency mining company stationed in Canada , has bought more than 2,000 new A10 Avalon mining machines… Read More
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Digital assurance: The "Killer app of Blockchain" according to VeChain According to Sunny Lu, the co-founder, and CEO of VeChain,… Read More
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KANSAS CITY, Mo. -- FOX 4's Russ Simmons and Shawn Edwards are back in the screening room with the latest on the Hollywood's latest releases including their thoughts on the final "Hunger Games" film.
They stretched it out as long as possible and the padding shows, but the "Hunger Games" saga has finally come to a mostly satisfying conclusion. "The Hunger Games: Mockingjay – Part 2" succeeds mainly because of its star, Jennifer Lawrence. She hits the bull's eye as the reluctant leader of a political rebellion in the dystopian future.
It's hard to see how this violent action flick got away with a PG-13 rating, but it's an involving spectacle. Thanks to Lawrence's riveting presence, Katniss Everdeen will go down as one of the great characters in the history of action movies.
Shawn says the last installment is, "on par with the previous movies. The conclusion is somewhat satisfying but awfully drug out."
RUSS: 3 Popcorn Bags
SHAWN: 3 Popcorn Bags
"Daddy's Home" is a raunchy family comedy starring Will Ferrell and Mark Wahlberg as a stepdad and birth dad vying for the kids' affection. As you might expect, it's broad and silly, but ultimately it's a 'by-the-numbers' effort.
Shawn says, "Mark Wahlberg and Will Ferrell have very little chemistry together in this throw away movie."
RUSS: 2 Popcorn Bags
SHAWN: 2 Popcorn Bags
Freestyle Releasing
On the other end of the cinematic spectrum is "The Letters," the biography of Nobel Peace Prize laureate, Mother Teresa. Juliette Stevenson is rock solid as the woman who achieved accolades for her sacrifice and work with the poorest of the poor in India.
This handsomely produced and well-acted film was written and directed by Clinton, Missouri native William Riead. Although it is extremely slow moving and austere perhaps to a fault, "The Letters" is a well-meaning tribute to a modern day saint.
Shawn says, "It's a nice attempt but should have been way more engaging."
RUSS: 2 Popcorn Bags
SHAWN: 3 Popcorn Bags
"Like" Fox 4 Screening Room on Facebook!
Click here to receive weekly emails full of FOX 4′s entertainment news!
What's our criteria for reviewing a film and awarding the popcorn bag ratings? Click here to find out.
Follow on Twitter: @fox4kc @RussSimmons1 @sedwardskc


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This is your opportunity to meet skilled candidates ready to begin their careers. The 2nd Annual Reverse Job Fair allows employers to tap into a diverse workforce of candidates ready to transition to work. Be prepared to experience role reversal at this non-traditional job fair where the candidates set up displays and the employers move from table to table to meet the candidates.
DATE: Wednesday, April 24th, 2019 | 8:30am-10:30am
LOCATION: Wood Lake Meeting Center
REGISTRATION: Free and open to all employers and public. Registration is preferred.
ACCOMMODATIONS: Please contact Heather Grummons at 507-923-2844 or email@example.com to request an accommodation.
CANDIDATE NOTE: This registration is designed for the employers and other similar interested parties to let us know they are interested. IF YOU ARE A CANDIDATE who would like to participate, please contact Dawn Kirchner (firstname.lastname@example.com) to register.
Are you an employer interested in reserving a job fair exhibitor booth?
Let's get started...


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HCM CITY (VNS) — Teenager Nguyen Diep Phuong Tram completed a haul of eight golds and six records as HCM City won the National Junior Swimming Championships yesterday.
HCM City's swimmers dominated their opponents at the Tuyen Son Sports Complex to claim a total of 56 gold, 44 silver and 42 bronze medals.
The Military Sports Centre 5 finished second with 11 golds, eight silvers and five bronzes, while Quang Binh came third with eight golds, eight silvers and nine bronzes. — VNS


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KT Corp., South Korea's second-largest mobile carrier, unveiled Tuesday a new mobile wallet app that picks the best credit card or discount coupon benefits for a user to pay for a certain service, as the company pushes deeper into the mobile payment platform business.
Its new smart wallet, CLiP, can organize discounts or pay-by-installments at designated stores -- common ancillary services offered by credit card companies in South Korea -- to tell the user which card is the most beneficial for that specific payment.
South Korea has the highest credit card usage in the world, with a ratio of 89 percent of the population, according to the Bank of Korea. Every South Korean owns at least two credit cards.
But because every credit card offers different discounts or payment benefits, it has been a hassle for users to have to either remember or figure out on the spot what benefits are available.
CLiP, created in joint efforts with KT's subsidiary, BC Card Co., is made to ease the cumbersome job for smartphone users, KT said, as its affiliations with more than 110,000 stores and collected data on more than 2,500 credit cards are embedded in the mobile wallet to help the user find the right one.
CLiP will operate under a network of 180,000 Wi-Fi hotspots, a feature that distinguishes itself from other existing mobile wallets sold by financial companies and IT firms, which makes the search for the best card possible, KT added.
"It's a service that has maximized user benefits at offline stores by putting together the complicated membership and voucher information in one mobile wallet," Nam Kyu-taek, head of KT's marketing division, said.
KT plans to add its own mobile payment tool to the CLiP wallet by October, which it expects to make the payment process much handier for the user, it said.
The app is available for download via the App Store and Google Play.
South Korea mobile carriers are tapping deeper into the mobile payment sector through tie-ups with local financial firms, as a new industry, known as fintech, has emerged as a fresh growth driver.
KT introduced its first mobile wallet, MoCa, in late 2012. SK Telecom Co., the top player, has its own, named Syrup Pay, run by its affiliate, SK Planet Co., with smaller rival LG Uplus Inc. operating its mobile payment tool, Paynow. (Yonhap)


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Davido's Personal Assistant or Houseboy like he loves to be called, Aloma drops his brand new single titled "30BG".
He doesn't go solo on this one as he teams up with the rave of the moment, Zlatan to bring some spice to this song we think would most likely be a potential hit single.
Listen and Download below:-


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Blending/Bottling Our 2012 Proprietary Red, Pathologiē
We had an amazing time last week in Sonoma, California, at the winery. We managed to finalize the blend of our new proprietary red, 2012 Pathologiē™, and bottle it…all in one day! We will wait out the "bottle shock" and plan to release our newest wine to our wine club members late April or early May 2014! Check out more photos from blending and bottling in our Photo Gallery.


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Get your Passport to Adventure
Calling all Cub Scouts! We've got so many fun programs this summer as we travel the globe at every camp. Check out our Cub Camp website and keep your eyes open for our Cub Scout Camping brochure to arrive in the mail any day. We want to stamp your passport!


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Flights from Romania to Saudi Arabia from EUR 507*
Book the lowest airfares from Romania to Saudi Arabia*
Flights to Dammam (DMM)
From Bucharest (BUH)
FromEUR 507
*All amounts are in EUR. Taxes and surcharges are included. No booking fee is applicable, but a payment surcharge may apply. Prices shown may vary depending on fare availability. You will see the final amount when selecting your payment method.


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Live an extraordinary life and awaken your dreams!
The Secret to Teen Power explores the Law of Attraction from a teenager's point of view.
Find The Secret to Teen Power in these formats:
Imagination is the creative force of the Universe!
The Power of Henry's Imagination is a picture story book exploring one of The Secret principles: visualization.
Find The Power of Henry's Imagination in these formats:
The easiest, fastest way to lasting happiness is to practice gratitude.
Find the 28 most powerful gratitude practices in The Magic!
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The simple secret to having more money is believing you are already wealthy!
Every single time you use The Secret to Money App you are thinking and acting like you are wealthy NOW.
Explore The Secret to Money App, available on:
Love everything around you, and the love MUST come back to you - a hundred fold!
The Power reveals the greatest force in the universe, and exactly how to use it - for better relationships and for everything you could ever want.
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Whatever dream you are dreaming, KNOW that the Universe wants you to succeed.
Hero lights the way for your dream - step-by-step through every challenge, hurdle, or set back - until it is realized.
Find Hero in these formats:
Patty Z
The first steps!
Jenny Penny
After many months of watching The Secret but not practicing it for some time, I ultimately decided to fix my debt problem. I had owed around $5,000 Canadian dollars to my Mom on her credit card. After the realization that I could not pay back money for debt that was already incurred, I changed my vocabulary and decided to pay forward to my Mom the $5,000 I owed her.
This instant change in vocabulary and communicating to my subconscious, changed my state and I began to feel wonderful about the idea of paying my Mom forward a check for $5,000. Unfortunately around that same time, my grandfather passed away but as a result of events and circumstances that had occurred previously, I received a portion of his inheritance and it contained four times the amount I was asking and thanking the Universe for. Not only did I pay my Mom forward the money I owed her but it has given me much peace of mind the past year.
Now I intend to attract even larger sums of money. As long as it is backed with unwavering faith and belief, the law of attraction will work and happen for anybody! Thank you, thank you, thank you!


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Soundlab feature Dermot
Thanks to Soundlab for their recent mini Q& A with our Dermot. Read about it here:
Thanks to Soundlab for their recent mini Q& A with our Dermot. Read about it here:
Big thanks to Pete Ringmaster for his fabulous synopsis of 365
We all have different outlets for extreme emotions be they bred in grief, frustration, anxiety or romance for example. For many an artistic avenue is the release from such overwhelming trespasses and so it is with Reverse Family who are about to unleash a daunting but we can already assure you irresistible adventure for ears.
The Reverse Family is the solo project of Dermot Illogical, someone probably better known right now as Andreas Vanderbraindrain, the frontman of British outfit The Tuesday Club. Towards the end of last year, he released acclaimed debut album My Songs About Life Mid Crisis, a collection of multi-flavoured lo-fi experimental goodness which continues to hang around in the imagination and passions like an inescapable itch. It was an introduction which commanded attention and breeds real anticipation for the next epic outing with Reverse Family.
Starting in October, Dermot is releasing 365, a project made up of 52 EPs released as one a week for a whole year. Before panicking, shouting impossible, or mistakenly thinking anything that massive has to be more filler than thriller let us declare that with the evidence of the sampler sent by the man our way in our hands, it is going to be an escapade taking ears and imagination on a helter-skelter of honest and emotionally raw but instinctively fun exploration; a journey given greater intimate potency by Dermot's diary entry of that particular day by the way of 'sleeve notes'.
The tracks making up the project were all recorded DIY style at home between Jan 1st2015 and Dec 31st 2015 with Dermot playing every instrument and sharing every syllable. Everything heard is as played and recorded; no editing or tampering made with every song bred in heart and spontaneity. It is an organic air and array of textures which grips the imagination as much as the sounds themselves; a fly-on-the-wall like climate baring the same open heart as that of their creator.
The catalyst to the project was the death of Terry, the drummer of The Tuesday Club. His sad passing came just as the band was deservedly stirring bigger and bolder praise carrying spotlights, a time topped by the band supporting Toyah at The 02 Islington and releasing their most successful and critically acclaimed EP to date. It was a world crushing time for the band and especially for Dermot who was also coming to terms with divorce, life dictating and changing illnesses for both parents as well as the constant struggle of being self-employed. It was a time many would have buckled under but Dermot focused all the suffocating turbulence into his music and turned it into a creative quest, one which at times you feel probably completely took over his world but gave him a survival and now the listener a spark for pleasure and thoughtful contemplation.
As the tracks we have reveal there is no 'woe is me' self-pity fuelling the adventure. Yes, it scratches his open wounds at times and is not always sharing smiles but every moment is an open insight and reflection on his feelings across the evolving year of those challenges and the life around Dermot in St. Albans with plenty of knowing black humour involved along the way.
The first track swiftly grabbing years was Future son – The Twa Twa's, (day 8) of the creative pilgrimage. Instantly it reminds of 'My Songs About Life Mid Crisis' with its post punk twang and Dirk Wears White Sox era Adam and The Ants like character. A gorgeous hook lurks within the angular clamour, Dermot's vocal delivery a swinging flirtation matching the similar allure of bass. The structurally organic design of the track alone is a web of lust clasping shenanigans, the song in its whole a psyche infesting treat.
Some tracks have an even rawer sound and temptation than others, This house is empty (day 10) one which borders abrasive in sound but within its causticity is an instinctive funkiness which has the body bouncing and appetite eagerly exploring words and emotion. There is a sense of despair and also hope carrying new beginnings felt with the track, a conflict most of us are no strangers too at some point and can grab with nodding recognition.
The clutch of songs within the sampler show the great array of styles embraced by the Reverse Family sound, the outstanding I stand alone (day 13) a post punk natured infestation managing to sound like a mix of Fire Engines, Swell Maps and unsurprisingly The Tuesday Club with Dermot's distinctive tones yet is unique in every pore while MP3 (day 310)is a junction box of sonic wires casting a Devo meets Pere Ubu scented discord over the imagination.
The darker, grungier Faded colours (day 336) offers melancholy at its most magnetic, In my head (day 337) sharing a sonically and emotionally haunting incursion on the senses as pained as it is corrosively elegant, and both songs continue the broadening maze of flavours and emotional tempestuousness within the sampler alone. Like many tracks, each is also a relatively brief encounter; fleeting moments in an unsettled and often unsettling day though Bad cartoon (day 343) stays a little longer with its melodically jangling and evocatively persuasive as Bowie-esque toning draws the listener with seductive ease into its own personal melancholy.
The punk 'n' roll of Do it just for me (day 344) hits the spot just as easily, its tenacious canter a gentle cacophony of guitar, rhythms, and voice while I built a new contraption (day 356) shares a broad grin in its post punk/art rock pop. The pair relish in the addictive prowess Dermot constantly finds in his minimalistic but oh so potent grooves and hooks, though he saves maybe the most addictive for Breathy graffiti (day 365), its electronic poking the kind of inescapable nagging lust was bred for.
So that gives a hint of what is in store for us once 365 begins revealing its heart in a few weeks. It would be a little unrealistic to expect every one of the songs within the 52 EPs, each suggested to contain seven tracks, will hit the lofty heights of those on the sampler but do expect each to be the most honest and spontaneously shared temptations sure to intrigue and captivate like nothing else around today.
We for one just cannot wait!
The first of the 365 EPs will be released digitally from 2nd October 2017 via Perfect Pop Co-Op one a week through to the first week of October 2018 and samplers via Nub Country Records 1 per month for a year. For more information keep an eye on:
Big thanks to the Perfect Pop Co-Op for our inclusion in the new 10 page special feature on us in 'In the Club' issue 033. There are great insights inside on 365 by Roger Payne and Pete Ringmaster.
Big thanks to Roger Payne from associated press (also frontman with Harpenden based Country Punks – Hubcap Moon)
365 days in a year. 365 songs. Each song represents a single day in the life… A unique experience, a mini drama, a vignette, however dramatic or routine, emotionally charged or neutral, all reflecting the trials, pressures, normalities, mundanities anyone might experience in any given 24 hours…
This is a big undertaking to capture the epic undertaking that is life… As Dermot says himself –
"like what a day does, you get what's next, pretty much whether you like it or not and you deal with it, sometimes well, sometimes not… life in the now".
These songs were born in an instant; conceived and recorded in bursts of spontaneity, each one an immediate statement of intent. Honest and pure but raw, like a wound, then left as is, untouched by the temptation to correct mistakes, mess with, tweak and fiddle… The thinking being as if to begin overproducing would be betray their roughly hewn from the ether quality and the spirit in which they were recorded…
In this day and age, because of the immediate hands on technology available in music and recording, so much emphasis is placed on crafting, shaping, controlling, cleaning up and polishing the work that any sense of spontaneity or evidence of the initial composition can be eradicated in the process. Through this misguided desire to seek perfection often the "undesirable" mess of accident, glitch, character and, god forbid, human error is wiped clean.
Like many of the Anti – Art DADAists, post war action painters or improvisational poets, by relinquishing full control of their craft, allowing accident and chance to live and breathe through their art and the creative process, a new aesthetic was achieved and new value was given to the finished results. Similarly 365 sets out to embrace these ideals contravening the petty quest for perfection and with the courage of full conviction to the purpose of the project, takes on an appropriate punk ethic to achieve an exciting, vibrant punk sound!
"This was a test, an experiment… an exploration employing a semi-surrealist, stream of consciousness… Let's call it a bit Jackson Pollocks…"
The decision to start 365 as a "thing" hung, suspended in thought, like a ballerina on points on a razor blade… The narrowest movement, the slightest nudge either way could have been the difference between its existence or not! In this case, prevarication, apprehension and self-consciousness were the enemies of inspiration and, it was the light of inspiration, glowing in an otherwise dark place that motivated Dermot to reach inside himself and create something positive from the black swamp of his personal despair at the time… The death of a great friend and band mate, Terry, going through divorce, dealing with the serious illness of both parents among other traumas took Dermot to the edge…
Instead of retreating, shutting down, dimming the light by degrees, Dermot was shocked into action, turning to his passion for music to address the issues he was experiencing and face his reality.
"…just an average man from St. Albans, (once an ordinary city in England but now haven of the wealthy and bearded!). My style was spontaneous – I approached it how Terry's death had approached me, by shocking me into action…"
Not so much as hoping for an instant cure but maybe to find some way to begin healing those raw wounds… You could say Dermot created a home-made music for a home-made therapy…
However 365 in not an exercise in self-introspection or indulgence. Amid the elements of despair sits a healthy dose of black humour to ease the pain, along with many a pinch of salt observation to bring a wry smile to the listeners face… 365 is a creative triumph… 365 is wild scream of optimism… 365 is a credit of creativity and example of spirit and hope overcoming the darkness…
Our first official London date is tomorrow night at The Islington. We're on stage at 8.30
Shhh… don't tell everyone, but we've got some VERY limited edition samplers for tomorrow nights gig at The Social, supporting the Pocket Gods for their album launch party…
Our next gig is at The Social on Monday, supporting the much valuted Pocket Gods for their album launch. We're on stage at 8.30. It's Free entry so hope to see you all there!
Sunday 20th August. £4 Entry Free shot!


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Yvonne Clumpner
Fenton High Bensenville, IL Class of 1977
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