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If you would like to read my review of the last episode of The Flash, click here.
Synopsis: After Cicada's attack, the team realizes it needs to think outside the box to stop this dangerous new foe; Nora comes up with a plan that ultimately puts a team member in danger; Caitlin delves into her past. (TVGuide)
Writers: Jonathan Butler & Gabriel Garza
Director: Andi Armaganian
Rating: TV-PG
Running Time: 43mins
Airs: Tuesdays at 8pm on Space (Canada)/The CW (United States)
Just when it looked like The Flash was going to have a stellar season, an episode like this comes along and shatters all hopes and dreams. There are parts of it worth commending but overall the episode was a halt to the excitement of the two episodes that preceded it.
This week's episode begins with a flash-forward to the year 2032, with a young Nora walking through the Flash Museum into the Hall of Villains. Her voiceover sets the stage for this season's big bad, Cicada (Chris Klein). It's one villain Team Flash was never able to catch, and according to Nora, he has made his appearance too early.
Not only did Team Flash fail in bringing down Cicada, but so did Supergirl, the Green Arrow, the Legends, and the League (wait, which league?!). But Nora promises she has a plan to take him down, and once again we're left wondering if this is another attempt to impress Barry.
Meanwhile, Ralph answers a call from the CCPD during a robbery, which results in an epic fail thanks to his Elongated Man costume that becomes an overnight meme. Nora reveals her plan to use a Harrison Wells to help catch Cicada and the first one up is a German Harrison Wells. Unfortunately, he's too busy and recruits Harrison Sherlock Wells instead, er I'm sorry Sherloque.
Upon meeting the team, Sherloque is quick to reveal everyone's secrets including the fact that Iris may be covering up a tattoo from a previous lover (say whaaa?). Unfortunately, Sherloque comes with a hefty price but the team reluctantly agrees to pay it agreeing to sell off some equipment from Star Labs.
Sherloque isn't very intrigued by Ralph's presence since he too is an investigator, so Ralph joins Caitlin instead on a field trip to see her mom. She wants to learn more about her father's supposed death certificate and is convinced her mom is lying. After speaking with her mom, both Caitlin and Ralph find themselves skeptical of what she had to say.
They break into the file room which Ralph attempts to open by elongating his hand under the door, but this fails because of the security lasers in place. Luckily, Caitlin is able to guess the passcode (her birthday) and get into her father's file. They find an old game that Caitlin and her dad used to play, along with a suicide note that was addressed to her.
Sherloque believes he's identified the man behind Cicada, but when Nora and Barry go to investigate, they catch the culprit a bit too quickly and easily. It turns out the real Cicada is at Joe and Cecile's house and is using Joe as his next target to find Vibe, aka Cisco.
Barry is certain that the guy they caught is not Cicada, despite Nora's insistence that it is. It is here where Barry realizes that Nora is too eager to overlook the proper sequence of handling things, and tells her she has to slow down and think through before taking action.
The team is frazzled over why Sherloque didn't have the right guy, and it turns out it's because he's caught Cicada 37 times before, and it's always been the same guy. Barry points out that since Nora has arrived, things have changed slightly and it may be why it is no longer the same man that was Cicada in the multiverse.
Back at the West house, Cecile wakes up to hear Cicada trying to torture Joe, and ends up sending out a distress signal to the team. Cisco is the first to show up and before anything can happen, Cicada takes him and leaves while Barry shows up immediately after.
Sherloque is able to figure out where Cicada has taken Cisco, and when Barry shows up, his powers are drained from Cicada's daggers. As promised, Nora takes a moment to think through a solid plan and then tells Iris she knows what to do. She grabs one of the power devices from the Pipeline and heads to where Barry, Cisco, and Cicada are. She throws it to Cisco who tries to use it against Cicada.
But before he knows it, Cicada throws it back towards Cisco, and it feels like the title of the episode comes to fruition. But fret not, because this was all part of Nora's plan and Cisco is alive and well!
Back at the lab, Sherloque agrees to stick around while Barry and Iris ask Nora to move in with them. Caitlin realizes there is a message to encode from the stuff she found in her dad's file which turns out to be "Caitlin, come find me". And considering there is someone watching her, could it be him?
During Joe's brief time with Cicada, he tells Cecile that he can tell Cicada is a father, and lo and behold, he is! We see him visiting a child in a coma at the hospital, so there seems to be a lot more to learn about this character than meets the eye.
The episode ends with Sherloque questioning Nora about what made her come to this time, and if it was truly her decision. Based on her reaction, we're starting to wonder the same thing.
Score: 6/10
Check out my TV blog to read reviews, recaps, and much more! Be sure to follow me on Twitter, Instagram, and like my Facebook page! @watchwithreebs
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This Is Us Season 3 Episode 5: Toby Review
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Introduction Ipage Uk Support Number
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subset: commoncrawl


text: The purpose of United Student Body (USB) is to create unity within our school community. We do whatever we can to bring people together and make Loveland High a more welcoming and cohesive student group. Please contact Mr. Lee Freeman, sponsor, if you would like to join USB or if you have questions about USB (room C-70).


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Bruce Mason Centre: Last Night of the Proms'
22 June 2019 - 23 June 2019 , .
Dust off your song book and get ready to raise a glass at the Auckland Symphony Orchestra's most joyous concert of the year! From the soaring notes of Land of Hope and Glory and Jerusalem to iconic Brit-pop and well known classics, you'll be taken on a musical journey that'll have you waving your Union Jack and singing at the top of your lungs.
Last Night of the Proms' best of British musical selection is conducted by Peter Thomas and features over 150 performers including New Zealand pop royalty, Suzanne Lynch of The Chicks and The Lady Killers, up-and-coming tenor Harry Grigg and guest choir North Shore Chorale.
Don't miss one of the feel-good concerts of the year!


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Life Story
We won't give you an uber long life story. We brew the coffee and get on with it …
We won't give you an uber long life story. We brew the coffee and get on with it …
We don't believe in sitting still. It's rather dull. Instead, we like getting out and meeting new people to do fun things with. Even go to the beach.
Not a word we like using. If you're unsure about something, give us a call, we'll work it out.
A much overused word but one we think does fit our ethic. After all, we can make coffee AND tea … AND hot chocolate
We hate delays… as I'm sure you do too. Nuff said.
New talent. We're always working to bring in new voices.
Whatever you do, say it at the correct volume. Something our voices know all too well.
In our line of work it's usually about listening, but it's also about observing, attention to detail …
We'll always offer the best impartial advice we can.
Makes the day go that little bit better.
Hopefully positive energy. For positive reasons.
OK we cheated. But pretty much a staple diet in the studio and the office. Have to be chocolate though. We're fussy like that. (Donations/sponsorship accepted.)
We are not amused. Actually that's a fib because we are, a lot. See if you can amuse us over on Twitter … @londonVO
We will always strive to get you exactly what you had in mind.
What's drunk after a job well done. (Feel free to substitute your own favourite tipple in here.)
Christa is fun and is a ball of energy. Her personality shines through in the studio and she is always a joy to work with. She has a bright, energetic, engaging and flexible voice. She is a natural mimic who is able to change her accent/ tone/pace and pitch to any project. Having trained in the UK and New York, Christa's acting and singing skills enhances her adaptability in the studio. She has toured Europe using a South American accent in a play voiced a video game with a Nigerian accent , used an RP accent for a Vodafone corporate and used a younger tone for Macmillan to name a few; if you need an all-rounder, Christa is the right person for you.


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Price, specs and more Coolpad Cool Play 6 launched in India: The device is powered by Dual core, 1. We can help you: Huawei Mate 20 review. From Around the Web. Other sensors include Light sensor, Proximity sensor, Accelerometer.
|For Personal Use Only
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The dual sim works flawlessly. With LocationOf you can view the location of one or more mobile devices live from your desktop computer, or, within the mobile application itself. Touchscreen is responsive already capacitive. View a Demo Map.
Lenovo A – Full phone specifications
Other sensors include Light sensor, Proximity sensor, Accelerometer. S has only single-band 3G while A has dual-band, is it ok for S??
Though the GPS may need a longer time to lock secondsbut I read there is a fix around. We can help you: So, does it have a fingerprint sensor?
The device is powered by Dual core, 1. Xiaomi Redmi 3 Pro. Rate Device Review Device. I want to know if there is an Lenovo A Specifications Summary.
How to download free Stream – Live Video Community for Lenovo A800
You can download it here. To verify, just follow the link in the message. Lenovo is a china company who had bought IBM division. ,ive Miix 2-in-1 20 smartphones liv got a price cut recently Looking for a smartphone? The sound quality is above average phones, though it is not Dolby yet there is another lenovo series which use Dolby. I bought my unit in less 12 hrs from now and the icon desktop software crushed twice already.
Lenovo A800 Real-Time GPS Tracking
Huawei Mate 20 review. Here are 10 you can pick from Unboxing: And I can see the reason The company also designs, develops, manufactures and sells servers, electronic storage devices, IT management software and smart televisions. Follow mobile devices while our application is installed Show the location of multiple mobile devices on the map Display statistics about routes traveled Help you make time and money-saving decisions with a quick glance Keep in mind, we can not help you: Good price for the spec.
And all I can tell you is: Lenovo accounts for Inthe China-based manufacturer made two major acquisitions: Please note that in order for GPS tracking to work the LocationOf app and the device must be actively on and be connected to a network.
Lenovo is the biggest computer maker and the fourth biggest smartphone maker in the world. Trace or find lost or stolen mobile phones Locate phones using phone or IMEI numbers If you are looking to recover a lost or stolen device, or, want to find a friend based on his or her phone number, you are in the wrong place.
Lenovo A live wallpapers free download. Android live wallpapers for Lenovo A
I want to know if there is any trusted reseller of this phone near my country China, Philippines, etc who can ship it to me. And S has Dolby and 2 speakers but not A, please which one??
We have sent you a verification email. I have this phone for one week. Price, specs and more Coolpad Cool Play 6 launched in India:


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Amber Gray Styling: Given the stealth release and its disjointed link to other church materials, many bishops didn't believe it was a Mormon-sponsored site at all -- even after they'd seen it. It's just having a specific edge to your voice. Gay dads Matt and David Clark-Sally talk about coming out, parenting as gay men, and reconciling faith and sexuality. Step 3: Step 1:
You don't have to use them, but it's one secret we've kept from most of the gay community for decades so we have to keep it going.
Here are my suggestions: Sports, art, theater, music, hobby clubs, volunteering, etc. You can collect signatures for marriage equality or you can join an Occupy protest and fight income inequality, but never stop fighting. There are other teens who have been there themselves and offer their advice:.
Even then it's still not infallible whenever European tourists are around.


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2006. Uganda Bureau of Statistics. This point shapefile shows the locations of district centers in Uganda for 2006.These data are intended for researchers, students, policy makers an... Uganda Bureau of Statistics.
2. Major Centers: Acholi District, Uganda, 2006-2009
2006. Uganda Bureau of Statistics. This point shapefile represents the major centers of the Acholi District in Uganda. Data were collected by humanitarian partners during 2006 - 2009... Uganda Bureau of Statistics.


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HOME Events and exhibitions Exhibitions
Laboratories of The Planet Ocean
- Details
- Last Updated on Wednesday, 21 January 2015 13:45
On January 22, the Museum of the World Ocean invites you to The Laboratories of The Planet Ocean exhibition. It is a unique opportunity to get to know the future expositions in the new museum building to be opened in 2018.
Exhibits correspond with the concept of the laboratories and show what visitors of The Planet Ocean can see and try there.
There are six laboratories planned in The Planet Ocean museum building.
The Earth Laboratory will tell about the history of our planet, its structure and the earth's crust formation. Here you can get to know about drift continents, oasises on the seabed, etc.
The Life Laboratory will present amazing encounters with sea inhabitants and the history of biopoiesis and evolution.
The Water Laboratory will reveal the secrets of this fascinating liquid and The Air Laboratory will help you to understand the processes both in hydrosphere and atmosphere.
The Space Laboratory will answer the question whether there is life on Mars. Guests can visit exploratorium, see stars in the sky and make voyage through time.
The Beauty Laboratory will be a terminal station of the tour around The Planet Ocean. Here you will find various leisure elements: view terrace, art exhibitions, thalassotherapy, water sampling, etc.
That is how the new museum building will look like in several years. And at the present moment every guest can peep at half-open door at The Laboratories of the Planet Ocean exhibition to get know the future laboratories and other interesting new things.
Mammoths Are Coming
- Details
- Last Updated on Monday, 24 November 2014 13:18
The Sea Inside Me by Vivi Navarro
- Details
- Last Updated on Tuesday, 07 October 2014 21:31
Museum of the World Ocean invites citizens and guests of Kaliningrad to make a voyage. Starting from October 8, you can get acquainted with the sea by Vivi Navarro. French marine seascape artist shows her love to the sea in her pictures. You can see trawlers, cargo ships, sailing boats and... people on her canvases. Vivi took part in many voyages aboard various ships and made sketches and drew during her travels. She drew crew members' portraits, rigging, memories about sea dangers and sometimes wrecks in the Strait of Gibraltar.
The commander of the French Navy awarded Vivi Navarro for her work. She was a guest on the Kruzenstern and the captain invited the artist to the voyage on the legendary sailing boat. Having come back she made new drawings in her workshop and then was aboard again, on the largest container ship ever named Marco Polo this time. She was to depict the maiden voyage from Zeebrugge to Shanghai!
Her works were displayed in many art galleries. In 2009, the artist was invited to the Musée de la Marine in Brest to present her sketches devoted to the Jeanne d'Arc. She was also invited to the Musée de la Marine in Paris in 2003, 2005, 2007 and 2009.
Now guests of Museum of the World Ocean can get to know the picturesque canvases by the French artist who owned that she's got the sea inside her.
The exhibition is prepared in cooperation with the Baltic State Academy of Fishing Fleet.
Silicic Souls exhibition in Olszhtyn (Poland)
- Details
- Last Updated on Thursday, 18 September 2014 15:38
Silicic Souls exhibition by Oleg Kozhanov, Kaliningrad artist, was opened on September 5 in the Olsztyn Planetarium (Poland) within the cultural cooperation between Olsztyn Planetarium and Museum of the World Ocean.
The exhibition moves visitors a thousand years in the future and can change one's mind about the reality. Mysterious future world was created by Alexey Kozhanov, Kaliningrad artist. Today the author is famous worldwide as a concept artist of Prometheus science fiction film by 20th Century FOX.
Silicic Souls exhibition is something special, something that shows development of humankind from an unexpected angle. The images of this unbelievable World were created by combination of various digital techniques in such a way that they look like photographs made by the author. The works tell the legend about striking progress of the Humankind in areas linked to transformation of biological structures, about how artificial silicic souls are getting father and father from people but still keep dreaming on Miracle.
The exhibition consists of 21 original prints, 3D sketches, slides to watch in 3D glasses and two videos (a trailer for Prometheus movie and an abstract of a documentary about filming).
Mr. Jacek Szhubiakovsky, Director of the Olsztyn Planetarium, expressed his sincere gratitude for organizers of the exhibition and noted that joint projects between the cultural institutions are long-term and regular ones.
The exhibition works till December 5.
The Arctic Reveals Its World
- Details
- Last Updated on Wednesday, 16 July 2014 14:26
Museum of the World Ocean invites you to the opening of a new exhibition on July 18 at 16:00. You will not stay indifferent after visiting this exhibition: about 150 photographs by authors worldwide will show amazing and unbelievable beauty of the Arctic. The works took part in the Global Arctic Awards International Photo Competition.
The competition was organized by true fans; authors dealing with north and arctic photography from 40 countries worldwide took part in the competition during two years.
The purpose of the project is to show the variety of life in the North and the Arctic, their history, culture, way of life and centuries-old traditions of native peoples, richness of animal world and environment as well as to draw attention to problems of the Arctic. The contest's motto is "Photographers of the World are for the Clean Arctic!" Forty-two medals and twelve ribbons of international associations were awarded to participants. Worldwide famous professional photographers from Russia, Ukraine, the USA, Austria, Sweden and Great Britain were on the jury.
Sergey Anisimov, Yamal photographer, and the Government of Yamalo-Nenets Autonomous Okrug were the organizers of the photo competition. National Geographic was a general partner. RGO, UNESCO, WWF, IFAW and many other companies were partners.
Global Arctic Awards International Photo Competition got accreditation in the following international photographic societies:
PSA- (The Photographic Society of America)
UPI - (United Photographers International)
FIAP- (Fédération Internationale de l'Art Photographique')
RPS - (The Royal Photographic Society, Great Britain)
Works by professional photographers from 21 countries worldwide recognized as the best specialists are presented at the exhibition.
Sergey Anisimov is going to make a workshop and tell about photography in difficult conditions of the North.
You can have an opportunity to see the beauty of the Arctic as it is in real!


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text:
George Soros
Season 9 Episode 1 | 56m 30s
Can the war on terror be won? Is global cooperation in decline? In 2006, financier, philanthropist, and philosopher Gerorge Soros discussed these issues and his book The Age of Fallibility: Consequences of the War Terror with John Podesta, former chief of staff to President Clinton and head of the Center for American Progress.
Aired: 10/01/06
Problems Playing Video?
You give every Kentuckian the opportunity to explore new ideas and new worlds through KET.


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Research & Accreditation
Research & Accreditation
Dr Bill Wolverton is a retired, former NASA scientist who spent over 30 years exploring and investigating the impact of plants on indoor air pollution.
Dr Wolverton's has been recognised as one of the world's foremost authorities in the use of natural processes for environmental pollution control. His studies have been published in over 70 technical papers, include a Ph. D in Environmental Engineering (1978) and a B.Sc in Chemistry (1960).
Dr Wolverton published two exceptionally informative books:-
Eco Friendly House Plants: 50 indoor plants that purify the air (1996 ISBN: 0297 83484 3)
Some of Dr Wolverton's most pioneering work was undertaken in conjunction with NASA during research relating to plant based options for closed ecological life support systems. The aim of the research was to identify ways of mitigating issues arising from indoor air pollution generated during long distance space travel.


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Golden Sparks.
I guess everybody is probably looking forward for tonight party since it's Christmas Eve today. In Hong Kong Christmas Eve isn't a public holiday and most of us still need to go to work. So I came up with an outfit that does not exaggerate 'go to work with' but still could rock the Christmas welcoming party after. My key for the whole look was the sparkle. A black top with the gold sparkles is a perfect option. I paired it with a vertical stripe skirt that also has a small golden line in between. For shoes, I threw on a pair of boots with gold decoration. It's a settle look, but under the light of the party you will be shining from the light reflection and at the day all you need is to add on a blazer and there you have a appropriate work look. If it's get cooler at night, you can always put on a jumper over the blazer for extra warmth. Anyway I hope you guys have a good Christmas Eve time and stay safe!
Lip - Lime Crime (Carousel gloss - Candy Apple) IG Store @ Mb.itch
Choker - Forever 21
Jumper - Yahoo Online Store
Blazer - H&M
Top - Thrift Store
Skirt - Thrift Store
Boots - H&M


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Broaching Cluster
My New Year's resolution for IHC is to increase awareness for headache and facial pain. I will take the next several blog posts to go over basic headache information and some lifestyle strategies that can help.
In general, terms used to describe primary headache syndromes are often misunderstood and misused. Labeling a headache does not change the degree of burden on an individual, but putting a name to it can help with coping and, from a medical perspective, correctly identifying the neurological process can better guide treatment and facilitate communication with other providers.
The International Headache Society published the International Classification of Headache Disorders (ICHD), updated to the third edition in the past few years. The main primary headache syndromes include migraine, tension-type headache, and trigeminal autonomic cephalgias. While the first two are terms commonly used (sometimes misused) in everyday discussions, the last is more obscure.
Briefly, trigeminal autonomic cephalgias (TACs) are one-sided headaches accompanied by autonomic features such as lacrimation, flushing, runny or stuffy nose on the side of the head where the headache is occurring. This class of headaches includes types like hemicrania continua (literally: hemi = half, crania = head – continuous headache on one side of the head) and "cluster headache."
Cluster headache deserves a blog of its own, which is upcoming as we cover basic headache topics. Cluster headache is the most painful headache condition known to mankind. Indeed, this headache type was once referred to as "suicide headache".


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UK weather forecast: Arctic blast to BLANKET Britain with snow NEXT WEEK
THE UK basked in warmer temperatures this week, but the cold weather will soon return. Here is everything you need to know about an Arctic Blast that will blanket Britain with snow next week.
The clear blue skies will quickly disappear next week, as grey clouds filled with rain will kick off the change in weather. The mercury will also drop, leading to temperatures to plummet to 0C. A weather warning was also put in place by the Met Office yesterday, due to low visibility along the English Channel coast from Kent to Devon causing travel disruption.
Met Office forecaster Richard Miles warned snow could return next week - before March arrives - as temperatures could reach as low as -2C.
He previously said to the Sun: "We could well see some snow by the end of February.
"Temperatures could go as low as zero to two degrees next week, and I'd expect to see a lot of frost if that happens.
"Weakening fronts could also bring showers on Sunday and Monday.
UK weather forecast: Snow could return to the UK next week
"After that it could be mostly dry with some sunny spells, but temperatures won't be quite as warm.
"There's a lot of fog around today, especially in the South East - but that should clear up by the end of the day."
What is the weather forecast for next week?
Today will be dry with lengthy spells of sunshine for central and eastern parts during the morning.
However, a few mist and fog patches are likely in the early morning, according to Meteogroup UK.
Western parts will be cloudy with patchy light rain. This afternoon, there will be cloud and showers for central and eastern areas.
Tonight will have a dry start to the evening with clear spells for many.
It will be mostly cloudy in southern England, Wales and parts of Scotland with a few light showers.
Later in the night, it will be dry with clear spells for many but it will remain cloudy in the far south.
There will be a mixture of sunny spells and showers on Monday morning.
The afternoon will be mostly cloudy and showers will continue for many, these frequent in the north-west.
Tuesday will start mostly dry and bright but it will become cloudy in the afternoon with rain in the north.


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The Foil takes aim at the big boys in the aero category thanks in large part to its impressive stiffness numbers. Yet it maintains spritely handling and a touch of comfort more indicative of the all-around category, which makes it a successful crossover.
It's the 73-degree head tube angle and short 405-millimeter chain stays that allow the Foil to bridge the gap between the aero and all-around categories better than most bikes with airfoil tubing. We were especially impressed by how at-home it felt on the climbs, but perhaps we shouldn't have been, given its 15.17-pound build.
It's no cobble bike (though Mathew Hayman did win Paris-Roubaix on it in 2016), but the Foil does take some of the sting out of bumpy roads, perhaps due to the lowered seat stays and the relatively thin seatpost. That makes it more than bearable for long days and big miles. Still, we'd stick to smoother tarmac where the aero features allow the Foil to flex its muscles. No need to shy away from the mountains, either.
Testers liked the comfort of the integrated Syncros handlebar, but it lacks any significant adjustability. And Scott has stuck with a rear brake mounted under the bottom bracket shell. This design makes rear brake adjustments more difficult and doesn't really seem to lend any aero advantage; we would love to see the rear brake relocated to a more traditional position, or better yet, a disc brake-equipped Foil.


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This is an original Fireplace surround
Overall Measures: 1800mm wide x 1200mm high 350mm deep.
It is 1540mm wide – from outside of pedestal side to outside pedestal side
The opening is 905mm wide x 935mm high
The pedestal sides are 340mm wide x 200mm deep.
(Hearth and heater pictured in the main shot are not available)
Has been removed by a stone mason and ready for collection.
It is in 4 pieces – see pics
It is in very good condition – the mantel top has had a repair done previously but this has been professionally repaired and you can't even see it – see pics
Pick up from the Sell4You Warehouse in Moorabbin
Pick up mid week or Saturday morning by arrangement
You will need a helper to help you lift as the pieces are heavy


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Is it safe to holiday in Tunisia?
Please be aware the Foreign & Commonwealth Office (FCO) currently advises against all travel to:
The FCO advise against all but essential travel to:
You can contact the emergency services by calling 197 (police — when in cities and towns), 193 (national guard — when in rural areas or small villages), 190 (ambulance) or 198 (civil protection — for assistance at incidents, such as car accidents, to provide medical assistance and response to fire).
A state of emergency was put in effect in Tunisia in November 2015 and has been extended a number of times, most recently on 5th of November 2018 by one month.
Please visit the Foreign Travel Advice page for more up-to-date information on travelling to Tunisia.
Tunisia trades in the Tunisian dinar and is what is called a 'closed currency'. However, it is illegal to import or export the dinar, so even if you find somewhere in the UK that sells the dinar, you'll have to change your money at the airport when you arrive. Make sure you not change too much, as you can only re-exchange 30% of the amount, and be sure to keep your receipts.
Tunisia is a predominantly Muslim country and while it is a favourite for western tourists from all over the world, it is advisable for western women to dress modestly and be respectful of religious and cultural customs when you're out and about. It isn't the strictest of Muslim countries, so short sleeves are fine, just have a light shawl of scarf on you in case you enter a religious building.
We would always advise that before embarking on your holiday that you consult with your GP 6-8 weeks before travelling. Both Hepatitis A and Typhoid vaccinations are usually recommended, and any required vaccinations are necessary to benefit from our medical insurance. While Tunisia falls under the parameters of our European travel insurance policy with us at Holiday Extras, we must stress that Tunisia is not in Europe and therefore your EHIC (European Health Insurance Card) is not valid here.
Top things to do in Tunisia
- The Bardo Museum is home to the world's largest collection of Roman mosaics.
- Visit the ruins of Carthage, former capital of the Phoenician government, on the shores of the Mediterranean.
- Breathe in the fresh sea air of Hammamet, a fishing town with gorgeous natural scenery and heaps of unspoiled charm.
- Delve into the Sahara region, where shifting sands and awe-inspiring landscapes are the norm, and hidden gems like Chenini village paint a unique picture of Tunisian life.
- Lake Ichkeul, populated by herons, flamingos and storks, offers an unparalleled bird watching experience.
Related content...
If you enjoyed this article and would like more info on travel to Tunisia, check out our other posts on the topic...
- Tunisian Cuisine
- A Brief history of Tunisia
- Top things to see and do in Tunisia
- Is it safe to travel to Tunisia
- Staying fit and healthy in Tunisia
- Best time to visit Tunisia
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Gmail Logon help: Discover ways to sign in your Gmail.com (Gmail.fr) account on a computer or cell phone. Logging into your Gmail account is usually as simple as entering your Gmail email address and password in the properly labeled text boxes. Remember that, if you use an Android, you must log into a Gmail account in order to set up the Android.
Gmail is really a free email service provided by Google. Messages received on gmail.com could be read utilizing a web browser or by using an email client. Nearly one billion Online users have a Gmail e-mail address.
Should you be getting an "cannot display this site", then this may be because of the browser. Your browser could be packed with junk, and so i will suggest you optimize your browser properly. If you don't learn how to optimize your browser, follow the rules mentioned below.
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Hepatocyte-specific deletion of Pparα promotes NASH in the context of obesity
Preprint posted on January 18, 2019 https://www.biorxiv.org/content/10.1101/488031v3
Fatty liver and PPARα: Is it all in the liver? Regnier et al. study the role of hepatic and extrahepatic PPARα in a mouse model of diet-induced obesitySelected by Pablo Ranea Robles
Defects in fatty acid homeostasis in the liver lead to lipotoxic tissue damage, such as hepatosteatosis. PPARα (Peroxisome Proliferator-Activated Receptor Alpha) is a nuclear receptor that plays a key role in metabolic homeostasis, modulating the expression of enzymes involved in fatty acid oxidation. Régnier et al. show in their recent preprint a novel hepatic-specific action of PPARα in the in vivo response against lipid overload (1).
Fatty liver disease is a global health burden. A recent meta analysis calculated a NAFLD (Nonalcoholic Fatty Liver Disease) prevalence of 25% in the global population (2). A characteristic feature of NAFLD is the accumulation of neutral lipids in lipid droplets (Fig 1).
Figure 1. Representative picture of a fatty liver from a NAFLD patient, stained with Masson trichrome staining. Steatosis is demonstrated by the big white "holes", that are lipid droplets, in which neutral lipids are accumulated to prevent lipotoxicity. Credit: Nephron [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0)], from Wikimedia Commons
NASH (Nonalcoholic Steatohepatitis) represents a more severe stage of fatty liver disease not caused by alcohol, characterized by inflammation (hepatitis) and liver cell damage. NASH predisposes patients to much more life-threatening conditions like cirrhosis or hepatocarcinoma. NASH treatment is still an unmet clinical need. Even though dietary and lifestyle modification can reverse fatty liver, unfortunately, few patients manage to achieve the target of weight loss and maintain long-term lifestyle changes. That's why pharmacological treatment is so important. In order to develop drugs that successfully target NASH progression, it is crucial to identify the molecular players involved in the pathophysiology of this disease.
PPARα is a transcription factor of the family of PPAR nuclear receptors. In metabolically demanding situations, such as fasting or exercise, and upon the binding of endogenous lipids as ligands, PPARα induction promotes the transcription of the enzymatic machinery required for the oxidation of fat. The potential of PPARs' (alpha, delta, gamma) modulation for the treatment of fatty liver diseases and metabolic disorders is already well known. Wy-14,643, a PPARα-specific agonist, prevents the development of methionine-choline deficient (MCD) diet-induced steatohepatitis (3). However, despite the beneficial effect shown by some drugs such as thiazolidinediones, PPAR agonists have adverse effects or limited potency (4). Whole-body knockout PPARα mice fed with high-fat diet (HFD) or MCD diet, developed more severe steatohepatitis than control animals (5–7). Here, the authors expand the knowledge of the actions of hepatocytic and extrahepatocytic PPARα in the progression of NAFLD in a mouse model of diet-induced obesity. They already showed in a recent report that MCD diet, ageing, and a short-term HFD induce more severe hepatosteatosis in hepatocytic-specific PPARα-deficient mice (8). In this study, the authors induced hepatosteatitis to mice by feeding them 12 weeks with a high-fat diet, and tested the role of hepatic and extrahepatocytic PPARα in this model. To ascertain the role of hepatic/extrahepatic PPARA they employed whole-body (Ppara–/-) and liver-specific Pparα knockout (Pparahep-/-) animals.
Key findings
A first hint on the extrahepatic role of PPARα was demonstrated by the fact that Ppara–/- animals became more overweight than WT and Pparahep-/- animals, even under control diet. This obese phenotype was not due to glucose intolerance, since Ppara-/- and Pparahep-/- did not present fasting hyperglycemia. Liver histology can provide valuable information of steatosis and inflammation in these animals models. The authors observed that HFD exacerbated steatosis in both PPARα-deficient mice much more than in WT animals, depicted by increased number of lipid droplets and hepatic triglycerides. Plasma markers of liver injury, ALT (alanine aminotransferase) and AST (aspartate aminotransferase), were only increased in PPARα-deficient mice fed with a HFD, but not in WT animals. Together, these data show how hepatic PPARα deficiency facilitates the development of hepatosteatitis in the context of obesity.
To better understand the molecular physiology underlying the development of steatosis under HFD in the different genotypes studies, the authors assessed the transcriptome response against HFD in the liver using microarrays. This approach allows to discern the specific changes happening in the liver of hepatic-deficient PPARA mice compared to whole body Ppara-/- mice. They found that only around 5% of the DEGs (differentially expressed genes) sensitive to HFD were regulated independently of hepatocyte or whole-body PPARα. This illustrates the crucial role of this nuclear receptor in the physiological response against a fat-enriched diet. The authors also inferred from this transcriptomic experiment that the response against HFD is different in hepatocyte-deficient PPARα mice and in whole-body PPARα KO mice. These different sets of genes induced or repressed in the different genotypes can shed light on PPARA-regulated responses that can be targeted for NASH treatment. A group of 337 genes were upregulated in Ppara-/- and Pparahep-/- livers, but not in WT, which suggests a negative regulation of these genes by PPARα. Among the enriched KEGG pathways in this set of genes, the authors highlighted inflammatory response, which supports the idea that PPARα is essential to prevent an exacerbated inflammatory response in a high-fat diet environment.
The authors also performed metabolomics in the livers of the different experimental groups, using proton nuclear magnetic resonance (1H-NMR) and targeted lipidomics. With the data obtained, they created a PLS-DA (projection to latent structures for discriminant analysis) model that, again, separated Ppara-/- and Pparahep-/- animals fed with HFD in two different groups, highlighting the role of extrahepatic PPARα in the response against high-fat diet. This extrahepatic PPARα response is also evidenced at the level of lipid metabolism since the lipids measured clustered in different groups depending on the genotype and diet.
What I liked about the study
I liked that the authors used a model (high-fat diet) that is more suited to the problematic of obesity and NASH, rather than other models already tested with a very similar approach.
The employment of two different knockouts (hepatic vs whole-body PPARα knockout), together with the integration of -omics techniques, allows to discern the specific hepatic functions of PPARα versus the extrahepatic functions. This is an important topic in the field, yet to be resolved, but the results of this study cast some light on the role of PPARα in the development of NASH.
Future directions and questions for authors
- Inflammation is a key point in the transition from NAFLD to NASH, but is not clear how the inflammation score in liver images was measured. A more detailed explanation in methods will help a broader audience to understand better how this was done.
- To which point is the transcriptome response in the different experimental groups similar or different to other NASH mouse models, in particular, related to inflammatory response? Here, I'm thinking for example in the recent paper from this group with same genotypes and MCD diet..
- It's clear with your data that extrahepatic PPARα is crucial for the homeostatic response in the liver against high-fat diet. Do you have any clue which other cell/organ could be important in this response mediated by extrahepatic PPARα?
- The most enriched pathway in the upregulated genes both in Ppara-/- and Pparahep-/- livers, but not in WT, is the lysosome. What do the authors think is the biological significance of this lysosomal "induction". This is an exciting discovery, given the link of lysosomes and lipid catabolism.
An important aspect that is not remarked by the authors is that the experiments were performed in thermoneutrality. Could the authors elaborate a bit more to the Prelights community on why they chose to perform the experiments in thermoneutrality? What would be the expected result if performed at normal ambient housing temperatures?
- Regnier M, Polizzi A, Smati S, Lukowicz C, Fougerat A, Lippi Y, Fouche E, Lasserre F, Naylies C, Betoulieres C, Barquissau V, Mouisel E, Bertrand-Michel J, Batut A, Saati T Al, Canlet C, Tremblay-Franco M, Ellero-Simatos S, Langin D, et al. (2019) Hepatocyte-specific deletion of Pparα promotes NASH in the context of obesity. bioRxiv:488031.
- Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M (2016) Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 64(1):73–84.
- Ip E, Farrell G, Hall P, Robertson G, Leclercq I (2004) Administration of the potent PPAR? agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology 39(5):1286–1296.
- Gross B, Pawlak M, Lefebvre P, Staels B (2017) PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD. Nat Rev Endocrinol 13(1):36–49.
- Ip E, Farrell GC, Robertson G, Hall P, Kirsch R, Leclercq I (2003) Central role of PPARα-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Hepatology 38(1):123–132.
- Pawlak M, Baugé E, Bourguet W, De Bosscher K, Lalloyer F, Tailleux A, Lebherz C, Lefebvre P, Staels B (2014) The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice. Hepatology 60(5):1593–1606.
- Abdelmegeed MA, Yoo S-H, Henderson LE, Gonzalez FJ, Woodcroft KJ, Song B-J (2011) PPARα Expression Protects Male Mice from High Fat–Induced Nonalcoholic Fatty Liver. J Nutr 141(4):603–610.
- Montagner A, Polizzi A, Fouché E, Ducheix S, Lippi Y, Lasserre F, Barquissau V, Régnier M, Lukowicz C, Benhamed F, Iroz A, Bertrand-Michel J, Al Saati T, Cano P, Mselli-Lakhal L, Mithieux G, Rajas F, Lagarrigue S, Pineau T, et al. (2016) Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. Gut 65(7):1202–1214.
Posted on: 7th March 2019 , updated on: 8th March 2019Read preprint
herve Guillou
Dear Pablo,
Many thanks for your constructive review.
We are currently revising the manuscript and will consider your review to improve the manuscript.
All the best,
Dear Hervé,
You are welcome. Thank you for you comment and good luck with the review.
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Our Retreat photographer will guide you through an experience of love and self acceptance. Allowing you to see the beauty and power of the goddess within. Capturing a perfect piece of you! You are then gifted a 8x10 print of your beautiful self, sent to you after the retreat. This gift is valued at $450!!!
Paint & create a piece of art. Tuning in and allowing the colours and textures to draw you in. A mindfulness practise and creative tool of healing.
Motivational Women who have found themselves through challenges, triumphs, mistakes, lessons and love. This will become a space to share, listen, support and grow whilst being inspired by just how strong and beautiful we all are.
We are not only spending the day filling your cup and nourishing souls, but your tummies too. Our catering team will provide you with a delicious, plant based, morning tea, lunchtime grazing and whilst you get lost listening to the incredible sounds of Nyssa Ray or Andrea Kirwin Live, We indulge you in a fine dining, three course dinner under the stars.
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Watch this space for future retreats and events.
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Back from Rio, 20 thoughts and notes gathered at and after the Rio+20 conference (in no particular order):
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- Assertiveness of developing nations, minorities and individuals
- Lack of vision, lack of leadership, results in near worthless document
- As were Copenhagen and other conferences, Rio+20 was not about a document or treaty anyway
- Rio+20 is a catalyst, another starting point to do more, a call to action since governments do nothing
- Incredible energy and enthusiasm of individuals: Rio showed a hint of what they can do
- Growing capacity of local organizations and corporations to take effective environmental action bypassing governments
- Europe although economically weakened, much more active and influential than the US
- Activity outside the main negotiating sessions produced hundreds of side agreements bypassing governments
- Like any trade show, the opportunity to meet people, make announcements, and the promise of many future smaller events
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The Surface Book 2 is one of the altered attractive laptops/tablets. The architecture of the Surface Book 2 speaks for itself, area the laptop/notebook comes with a advertisement articulation mechanism. The advertisement lower allocation of the laptop houses the I/O including the committed Nvidia GPU (in this case, the Nvidia GTX 1050.
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The Surface Book 2 has a full-sized USB-A 3.0 ports, SD agenda slot, 3.5 mm headphone jack, proprietary charging port, and a USB blazon C port. The blazon C anchorage additionally doubles as a affectation anchorage (USB 3.0 standards), which can be acclimated to attach a accessory awning (up to 4K) with abutment for charging. So, users can allegation from both the proprietary charging anchorage and the USB blazon C port. However, clashing the Apple MacBook Pro, the USB blazon C anchorage is not a Thundert 3, so users cannot attach alien GPUs.
The 13.5-inch archetypal of Surface Book 2 has a 13.5-inch PixelSense display, which is one of the best displays that we accept apparent on a notebook. The affectation comes with congenital 3000 x 2000px (almost 4K) resolution with 267ppi. If you are attractive for a laptop for media consumption, afresh annihilation can get bigger than the Surface Book 2, which offers real-life like colors and adverse arrangement of 1600:1.
The affectation can be abandoned from the abject keyboard with a bang of a on, which makes the Surface Book 2, a fully-fledged 13.5-inch book active on Windows 10 Pro OS. The accessory has a amazing affectation with choleric bottle aegis with high-precision blow input.
After absolutely application the touchscreen on Surface Book 2, we did acknowledge the ample laptop/tablet with blow support. In fact, Microsoft has done the best accessible with the blow awning on the Surface Book 2.
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If you are planning to get the Surface Book 2 for some artistic work, afresh get a approved or a gaming mouse, as application accoutrement like Adobe Photoshop, and Adobe Illustrator is not accessible on the congenital trackpad.
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The Surface Book 2 is not for everyone, not primarily for gamers, as gamers accept a lot of best for beneath than the bisected the amount of the Surface Book 2 with bigger if not agnate specifications.
The Surface Book 2 is for those, who affliction about the tiny detail about the product, who are attractive for a laptop, which can act as a book and can additionally become the able computer to do CPU and GPU accelerated tasks.
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If you are in the bazaar for a laptop with a account of Rs. 1,50,000 or more, afresh you can accede accepting yourself a Surface Book 2. This accessory is for students, creators, and designers, who are attractive for a MacBook Pro like laptop with Windows operating system.
The Surface Book 2 is the Microsoft's flagship product, which offers a complete Windows 10 acquaintance with exceptional attending and feel. Finally, a laptop which can attempt adjoin the brand of Apple.
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Flowers, a card and a framed collage of photographs greeted the former nurse when she arrived at Greenwood Tavern for lunch on December 13.
Pauline has been a member of the Easybeat Walkers and its forerunner, the Healthy Heart group, since 1999.
She still draws on her nursing knowledge, taking members' blood pressure before and after weekly exercise sessions at Padbury community hall.
'Pauline is a very valuable and respected member of our club. She got quite a surprise when she arrived for lunch,' spokeswoman Judy Mutton said.
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