text:
Health and disease phenotyping in old age using a cluster network analysis
Valenzuela, Jesus Felix
Monterola, Christopher
Tong, Victor Joo Chuan
Ng, Tze Pin
Larbi, Anis
Date of Issue2017
School of Biological Sciences
Published version
Human ageing is a complex trait that involves the synergistic action of numerous biological processes that interact to form a complex network. Here we performed a network analysis to examine the interrelationships between physiological and psychological functions, disease, disability, quality of life, lifestyle and behavioural risk factors for ageing in a cohort of 3,270 subjects aged ≥55 years. We considered associations between numerical and categorical descriptors using effect-size measures for each variable pair and identified clusters of variables from the resulting pairwise effect-size network and minimum spanning tree. We show, by way of a correspondence analysis between the two sets of clusters, that they correspond to coarse-grained and fine-grained structure of the network relationships. The clusters obtained from the minimum spanning tree mapped to various conceptual domains and corresponded to physiological and syndromic states. Hierarchical ordering of these clusters identified six common themes based on interactions with physiological systems and common underlying substrates of age-associated morbidity and disease chronicity, functional disability, and quality of life. These findings provide a starting point for indepth analyses of ageing that incorporate immunologic, metabolomic and proteomic biomarkers, and ultimately offer low-level-based typologies of healthy and unhealthy ageing.
DRNTU::Science::Biological sciences
Network Analysis
Network Analysis
Journal Article
Series/Journal Title
Scientific Reports
© 2017 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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text: Based on analysis of the amino acid sequence of complexes of polypeptides, extracted from animal organs and tissues, created Cytogens - short peptide chains having in its structure from 2 to 4 amino acids. These chains are copies of the "active regions" most significant in its group of polypeptides contained in the extracts. It allowed to create new class of drugs - parapharmaceuticals, collectively known as Cytogens. Cytogens- peptides of synthesized origin. Cytogens unlike the extracts (group of polypeptides) comprise one kind of molecules (most significant short peptide), they are recommended for use at the initial stages of peptide therapy as well as for short courses (10 days, 3-4 times a year) of the prevention of premature aging .

subset: commoncrawl


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We have just released an update to the SwagBucks NewTab Launcher (v0.0.1.1244) for the Google Chrome web browser. Which is available to download right now free of charge. The Newtab Launcher is now available with some tweaks to the URLs the extension links to.
Category Archives: Google Chrome
Mario Theme 2 Update for Google Chrome
We have release a mirror update to our Mario Theme 2 for the Google Chrome web browser – no major changes just a few bugs.
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It's probably not a surprise that English is the most popular language that our users use — but today, we published an update (v0.0.1.1721) to the Google Chrome Web Store for the My Downloads extension. My Downloads for Google Chrome is now available with loads of new languages, some minor tweaks and fixes to existing language files. It adds 19 more languages thus making a total of 24 supported languages.
Enjoy My Downloads even more by choosing from any of the following languages;
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There are still rough spots — notably with providing the right context around the phrases to be translated, and the speed with which we get new translations out. We plan to address these and incorporate further improvements to the comprehensiveness of our translations and the ease of submitting translations.
But 24 languages is a respectable number, and evidence of the amount of (much appreciated!) effort our users have put into improving the global My Downloads experience. We're proud of what has been accomplished so far, and excited to see My Downloads' internationalization support expand in coverage and accuracy in the coming months.
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- This event has passed.
Movies in River Mill Park-Avengers: Infinity War
September 7, 2018 @ 7:45 pm - 10:00 pmFree
The Town of Occoquan is proud to announce free Movies in the Park as part of our summer concert series, Music on Mill!
On Friday, Sept. 7, we'll be showing Avengers: Infinity War!
Movies start at sundown, about 7:45 p. m. for this date. Bring a blanket or lawn chair pick up a snack in town or pack your own and head down to River Mill Park for movie fun and stunning views of the Occoquan River. Feel free to come in costume!
Avengers Infinity War is rated PG-13.
Musical concerts are held on first Friday and third Saturday evenings at River Mill Park, 458 Mill Street, from 6:00 to 8:00 p. m. Concerts and movies are FREE and open to the public.
Cancellations: In the event of rain, call 703-491-2168 two hours before the event for cancellation information, or see the Town of Occoquan Facebook page: facebook.com/townofoccoquan.
Consider being a Friend of River Mill Park! To sponsor an event, contact the Events Director at [email protected] or visit the website: occoquanva.gov/summer-concerts.html.


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At Toccoa, all 14 of Jefferson's wrestlers qualified for next weekend's East Sectional championships as the Dragons easily won the Area 8-4A championship on Saturday.
The Dragons, which won its 16th consecutive state duals championship earlier this month and is now seeking its 17th straight traditional state title, scored 285.5 points to top Oconee County (163 points), Stephens County (151.5 points), Madison County (118 points) and St. Pius X (117 points).
Area champions for Jefferson included Christian Parten (106 pounds), Jared Blackburn (120 pounds), Ian Statia (126 pounds), Dawson Bates (132 pounds), Coy Strong (145 pounds), Mason Corbett (160 pounds), Caleb Little (182 pounds) and Nick Holman (220 pounds).
Jonathan Peavey (113 pounds), Cole Potts (138 pounds), Hunter Allen (170 pounds) and J.T. Middleton (heavyweight) all finished second in their respective weight classes. Gavin Blackburn finished third in the 152-pound division and Alex Parker finished fourth in the 195-pound class.
Oconee County had 11 competitors advance to sectionals. Jordan Silvey (113 pounds) and Dalton Sikes (heavyweight) led the Warriors with area championships. Second-place finishers included McCrae Claas (120 pounds), Camden Aycock (126 pounds) and Nick Sanders (220 pounds).
Third-place finishers included Hudson Grogan (132 pounds) and Braxton Brooks (195 pounds) and fourth-place finishes went to Taylor Webb (138 pounds), Isaiah Buffa (145 pounds) and Sam Howell (152 pounds).
The Class 4A East Sectional will be held at Jefferson.


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They travelled to Calabria, the toe of the boot, from all over the world. Eight adults and two children, they came to southern Italy from as far as China and as near as Venice to finish their long, multi-year, conversion process in the warm mikvah, the ritual bath, that is the Mediterranean Sea. Some had a Jewish grandparent or two, and felt like they were reentering the Jewish people. Some were spiritual seekers questing after Truth, and some felt drawn toward a religion constructed on foundations of doubt and constructive critical questioning.
The day before the mikvah, the beit din, the three rabbis who grant final approval to each convert, began convening in the fourth floor conference room of the Savant Hotel at around nine in the morning. One by one, each of the eight adults sat across from the beit din for about 45 minutes, answering questions about their journey and their commitment to Judaism. As this happened, I sat with the rest of the group three floors below and led a succession of seven classes about various topics: The burning bush, the prophets, Shabbat, Hasidic stories, the yetzer ha-tov and the yetzer ha-ra, tefilin, and King David. I spoke for a few minutes on each topic, and then community formed as we shared our thoughts.
I had the privilege of sitting in on the eighth beit din session, that of a German man with a young family. The new Jew was asked about his Jewish household. He replied with a story about his three year old daughter. As she was presented with her birthday cake this year, she saw the candles and instinctively covered her eyes and began reciting 'Baruch atah Adonai…' A rabbi asked him whether he was fully aware of the negative consequences of being Jewish. He was aware. The rabbi asked him if he understood what it might mean for his family, because when a brick is thrown through his window, that house belongs to his entire family. He understood. The rabbi, performing his due diligence, asked both questions again with slightly different phrasing. The new Jew demonstrated that he fully understood and accepted the consequences of tossing his lot in with that of the Jewish people.
The next morning, we gathered at the Savant Hotel and travelled by bus to a secret spot along the Mediterranean Sea, accessible by parking off the highway shoulder and walking through an underpass. The beach was rocky, and there were a few locals looking for privacy and two stray dogs, one of which could trace his immediate ancestry to at least one wolf. I waded into the water, and one of my cheap flip flops from the China Store, where made in China products are exclusively sold in Calabria, was quickly lost in the rough surf. A rabbi gathered the group together and gave a talk about identity and transformation. In his charming English accent, he spoke of Jewish superheroes: Superman, Batman, and Dr. Who, and the perils and thrills of assuming a new role in life. Then, one by one, the new Jews waded out toward me into the sea, and I watched and helped them as they interspersed the mikvah blessings with full dips beneath the choppy waters and popped out of the water as full members of the Jewish people. I bear-hugged each person and wished them a safe journey, both in Jewish life and across the strong currents and the rocky path toward the welcoming shore. As I exited the water, the husband of one of the new Jews smiled and excitedly held up my lost flip flop. What was lost was found, and the moment seemed complete.
We held a Kiddush on the beach, boarded the bus, and went back to the Savant to eat lunch and to present the new Jews with their official conversion certificates. While the bus ride to the beach had been one of nervous chatter and anxious excitement, the ride back was quiet, contemplative, and reflective. A true transformation took place over these two days, and the Jewish journey had just begun anew.
Until next time... Arrivederci...
(To learn more about Rabbi Barbara Aiello and La Sinagoga Ner Tamid del Sud, visit Rabbi Aiello's website at www.rabbibarbara.com).


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New Technologies Help Oregon Woman Accept Prosthesis
(PORTLAND, Ore.) -- When a severe infection caused Jan Schumacher, 58, of Portland Oregon, to lose her fingers, she preferred a functional prosthetic hand to a glossy silicone one that would look more natural.
"Jan came to us and told us she wanted something 'trick badass,'" said MacJulian Lang, a prosthetist and clinical director of Advanced Arm Dynamics in Portland.
Lang outfitted her with a prosthesis that looks more like a motorcycle glove than a prosthetic hand. The fingers move with a slight flex of a muscle in Schumacher's palm. Now, Schumacher is able to grab her coffee mug, lift weights, or even open a door.
And the glove-shaped prosthesis comes fully equipped with an iPod Nano -- not because it serves any prosthetic purpose, but because it helps the prosthesis look "badass," said Lang.
Two million amputees currently live in the U.S., according to the nonprofit Amputee Coalition, an advocacy group. An estimated 570 people lose a limb each day.
Now, more of those patients say they couldn't care less about fitting in and hiding their amputations. Instead, many say they are embracing their circumstances and finding ways to flaunt them.
"Long gone are the days of the wooden leg," said Lang. "Much more often now people roll up their sleeves and show the prosthesis for what it is."
Before her amputation, Schumacher owned one of the largest bridal stores in Oregon. Her store, "Tres Fabu Bridal," handled nearly 1,200 weddings a year. But after her infection and subsequent amputation, Schumacher had to close her store.
"I went from owning a business, to not even being able to open a door on my own," she said. "For many of us, the experience has been so debilitating."
Schumacher considered wearing a prosthesis while undergoing rehabilitation. But she said she did not know what to expect.
"First you think of the hook, like Captain Hook. But I was shown an articulated hand, so that gave me hope," she said.
Copyright 2011 ABC News Radio


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Ball Mill Business Industrial
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Apache 2.2.13 with Overflow Protection
With Apache 2.2.13, developers have closed security holes in the popular webserver.
A security bulletin reports problems concerning the Apache Portable Runtime (APR) and the Apache Portable Utility (APU). Both libraries were vulnerable to remote sources using integer overflow to launch "denial of service" attacks that could cause the application to crash. The execution of malicious code using the same external method was also a possibility.
The new version not only fixes the bug but also improves compatibility with test version 1.0.0 of OpenSSL. The changelog has a list of all changes. The
download webpage can be reached by following this link.
Issue 36: Getting Started with Linux – /Special Editions
Buy this issue as a PDF
The New Kali Linux Is Here
2019.2 supports more Android devices.
exFAT Is Coming to Linux
Microsoft has contributed exFAT patents to OIN and also published specifications.
Knoppix 8.6 Released
The latest version of the classic Live Linux comes with KDE Plasma 5.
openSUSE Board Gets a New Chairman
Richard Brown is replaced by Gerald Pfeifer.
Linux Mint 19.2 "Tina" Released
The latest version of Linux Mint brings many performance improvements.
Gnome and KDE Coming Together
The two major Linux projects will work together to create a compatible ecosystem.
Fedora CoreOS Preview Released
The new distribution from Red Hat is targeted at containerized workloads.
SUSE Appoints New CEO
Melissa Di Donato replaces Nils Brauckmann, who will retire and leave SUSE.
Debian Buster Arrives
The latest release of Debian comes with tightened security.
IBM Acquires Red Hat
Red Hat becomes an independent entity within IBM.


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The Buzz
St. Louis reporter duped into writing Eric Greitens comeback story
Key figures in the Greitens saga
For a few hours Wednesday morning, Missouri's political world was buzzing over a report that former Gov. Eric Greitens was plotting his political comeback.
But by day's end, the buzz turned to bust. The story was pulled offline with no explanation, and its author eventually admitted he'd been duped.
Greitens, a Republican, left office last June after an avalanche of scandals and criminal charges forced him to resign to avoid criminal prosecution and impeachment.
Almost from the moment he departed, rumors of Greitens' impending return to politics have swirled.
CityScene STL — a news site focused on real estate development in the St. Louis region — wrote Wednesday morning that seven anonymous sources close to the former governor confirmed he was jumping into the 2020 Republican primary to challenge the man who replaced him, Gov. Mike Parson.
"Each source, of which there are seven, have stated Greitens plans to run on a scorched Earth platform and one that is un-apologetically conservative," wrote Chris Stritzel, CityScene STL's founder. He later wrote that three of his sources said Greitens would announce his candidacy this summer, while two said it would be this fall.
Greitens could not be reached by The Star for comment, but a handful of Greitens' former political allies and donors contacted by The Star disputed Stritzel's reporting.
Just a few hours after it first published, Stritzel's scoop began to unravel.
In a series of emails to The Star Wednesday night, Stritzel said his story was based on five sources who reached out to him personally but turned out to be fake.
Stritzel says he was contacted unsolicited via email by five people claiming to be conservative radio hosts Pete Mundo, Dave Glover and Jamie Allman; former state Rep. Marsha Haefner and current state Rep. Nick Schroer.
He pulled the story down as he began to realize none of the sources were actually who they claimed to be.
"So the five sources are fake but at the time, I didn't know that," Stritzel said. "As for who they really are, I'm not sure, but two seemed to be written by the same person while the others wrote like individuals."
Schroer said Thursday he had never heard of CityScene STL until someone forwarded him the story on Greitens. He said he never contacted Stritzel, has no way of contacting Greitens and has no insight into the former governor's future plans.
Stritzel's two other sources, whom he describes as "friends of Greitens for sometime," were "iffy on wanting (the story) to stay out."
"It was also removed because five sources, the ones who lied and are not credible, admitted that they were coordinating their claims in the hope of destroying my credibility and wanting to stir the pot," he said, "but the other two were clear and truthful."
The story also references "longtime Greitens friend" Jeff Smith, a former Democratic state senator from St. Louis who tweeted last year about a rumor that Greitens met with a political donor about the possibility of a 2020 campaign.
Asked about the story Thursday, Smith replied: "Can I be quoted LOL-ing?"
"We've known each other for over 30 years but I wouldn't say we've been friends," Smith said. "He went to Duke, for Pete's sake."
Smith then turned serious and noted that he had never heard of the website, never heard of the story's author and had not spoken with Greitens for a decade, "back when the former governor was a Democrat."
Thursday afternoon, Stritzel tweeted that he "was duped into writing something almost entirely false. It was my fault for not checking the sources, so I pulled the story down."
"From the get go, I thought it was odd that I was contacted by the people named but I went with it," Stritzel tweeted. "I'll continue doing what I do writing and checking in on developments in St. Louis. It's my specialty. I'll leave politics up to the pros."


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Friday News Roundup – International
Prime Minister missteps, ongoing conflict between the U.S. and Iran, and climate change strikes around the world are big news stories this week.
When Julián Castro attended a meeting at The White House in 2009 as the 35-year old mayor of San Antonio, Texas, former President Obama looked down the table at him and said "I thought he was on our staff. I thought he was an intern. This guy's a mayor?"
He sure was. And then, Castro went on to become the Secretary of Housing and Urban Development under Obama.
Back in 2015, a National Journal profile described him this way:
But the spotlight shines most intensely on Julián, the San Antonio mayor who vaulted into the national consciousness with his keynote address—the first by a Latino—at the 2012 Democratic National Convention. Last year, when Julián left the mayor's job to join Obama's Cabinet as Housing and Urban Development secretary, the move stirred widespread speculation that he was being positioned as a potential 2016 vice presidential pick for likely nominee Hillary Clinton. Barring that, Texas Democrats have long envisioned Julián—or maybe Joaquin [Castro, his twin brother]?—as the state's first Latino governor. Or as a U.S. senator. Or maybe both.
Now, he and his twin brother Joaquin (who, by the way, is a member of the House of Representatives), are campaigning for upstart Texas Senate candidate Beto O'Rourke, who is running against incumbent Ted Cruz. Castro has also started a political action committee called "Opportunity First."
Castro's political career — which began when he was elected to the San Antonio City Council at only 26 years old — and his latest moves seem to be setting the stage for another major development.
So…will he run for president in 2020?
Has he given a speech at the Iowa State Fair, one good way to tell if a politician is probing a presidential run? Check.
Has he written a memoir about his humble beginnings? Check.
The book is called "An Unlikely Journey: Waking Up From My American Dream."
Julián Castro joins us to talk about his famous family, his future political plans and whether a Democrat can actually win in Texas.
Produced by Denise Couture. Text by Gabrielle Healy.
Excerpt from "An Unlikely Journey" by wamu885 on Scribd
Prime Minister missteps, ongoing conflict between the U.S. and Iran, and climate change strikes around the world are big news stories this week.
The president threatens action against California. His former campaign manager doesn't cooperate with Congress.
Millennials might be accused of killing a lot of industries. The plant business isn't one of them.
We explore one author's quest for truth in an increasingly fake world.


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FOREST MAKERS: Wreath-Making (Morning or Afternoon)
November 30, 2018 - December 1, 2018$25
Gather up friends and/or family and kick off the holiday season with our popular Wreath-Making Workshop. On Saturday, December 1st, Chris Hubbard will conduct wreath-making classes from 10am to noon, and again from 1 to 3pm; choose whichever session suits your schedule.
Wreathes are created on 14-inch frames; finished dimensions are limited only by your creativity. Ribbons, evergreens boughs, other natural materials and tools will be furnished, but you are encouraged to bring along your own decorations to personalize your creation. Register soon, these workshops fill up and each workshop only accommodates 10 working groups; the fee is $25 per wreath.


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Design Your Own Bedroom. As our lives become ever more frenetic, the haven that comfortable bedroom designs offer becomes more and more inviting – and not merely for sleeping. Quiet reading, television viewing (for the programs we want to watch), enjoying a peaceful light supper, letter writing – these are all activities that may be best suited to that particular special private space. The sack is generally considered as a sanctuary, a personal gateway that shows your chosen collection, color and feelings. Sometimes it takes few simple ideas to really get your creativity flowing. Many enthusiastic and young people want to understand bedroom decorating tips. Some main guidelines to keep in mind while decorating your bedroom are as follows:
Stanley Furniture Wethersfield Estate Bedroom Set from stanley bedroom furniture , source:pinterest.com, Author: Koncobolo
Select Subtle Color. Rather than choosing bold primary colors, select soothing color shades and a restful palate of homochromatic tones. Remember color schemes like the soft hues of green, blue or lavender are believed serene. Jewel -toned rich shades plays an important role in setting your mode and providing you with comfort and coziness.These often include topaz, toasty browns shades etc. Try employing a much toned down shade of your preferred color. This means use pumpkin in place of tangerine. Whether with a partner or not, we must look into our bedroom the main one area where we are obliged to please no body but ourselves (the words indulgence and pampering spring to mind). It therefore makes common sense for the'best'bedroom space and use of dressing and bathroom facilities to be reserved because of this purpose.
Crown Mark B1630 Stanley Antique White Solid Wood Queen Size Bed from stanley bedroom furniture , source:nyfurnitureoutlets.com, Author: Koncobolo
Maintain a straightforward bedroom. No matter what type of decoration you select, your bedroom must look sophisticated, elegant, cozy and simple.Leave at least a space of three feet between the side walls or big furniture and the bed, thereby ensuring easy movement.Apart out of this leave no less than two feet gap between the low level furniture's e.g. tables and the bed. Try furnishing your bedroom only with everything you require. Anything additional tends to offer a poor look. However you are able to place items of artwork like candles, family photos etc.
Stanley Santa Clara Platform Customizable Bedroom Set from stanley bedroom furniture , source:pinterest.co.uk, Author: Koncobolo
Main Bedroom Design Ideas. In regards to deciding upon main bedrooms design scheme, it is indeed a question of whatever takes your fancy: remember, this is your room! For preference, though, many people decide for soft colors and quiet patterns as they are considered less tiring on the eyes and more conducive to rest and relaxation. A clear part of contention is when two individuals of different persuasions try to concoct a scheme to accommodate both. This dilemma can usually be overcome by the skilful collection of colors and patterns mid-way between both tastes
Stanley Bedroom Set Luxury Best Bedroom Furniture Placement Ideas from stanley bedroom furniture , source:blognoithatcu.com, Author: Koncobolo
Select the correct size furniture. Another important room ideas for decorating includes selecting the best size of furniture. When you are prepared to search for bedroom accessories, consider a floor plan and the measurement of the bedroom space. Furniture found should easily fit in the bedroom. Avoid selecting heavy and large dressers and beds for a small bedroom. On another accessories which are really small tend to obtain lost in a big bedroom. Gone were days past when people lived in houses with only white painted walls, regular bulbs, and marriage and family photos in standardized photo frames. The trend today is to possess'live walls'that will talk for themselves. Each one of these having its own identity and narrating a unique story! Folks like to decorate their bedroom walls with theme styling that totally blends using their personality, life style and fits the bill too!
Stanley Furniture Crestaire Platform Bed Products from stanley bedroom furniture , source:pinterest.se, Author: Koncobolo
Create a personal nook. Here's one of my favorite bedroom decorating tips I like to talk about, and that's to create a quite area for yourself in your bedroom where you are able to sit and read quietly. Make a private reading or lounging space by using comfortable chairs and foot stool and placing them at the conclusion of the bed. Each someone to a unique, like they say! Today the market is flooded with suggestions to decorate your bedroom walls. Even if you are negative at interiors, the net may be your absolute best pal to complete mix and match and you can add your touch of creativity and personalize the bedroom walls.
Stanley Juniper Dell Storage Panel Configurable Bedroom Set ad from stanley bedroom furniture , source:pinterest.es, Author: Koncobolo
Buy luxurious linens. As interior decorating rule states, the usage of beautiful fabrics will help outfit your bedroom. Linens tend to incorporate comfort to the bedroom. Purchase sheets which are made from 100% cotton with a thread count of around 350 as well as more. Always send costly linens to the dry cleaner. They offer services like professional washing and pressing at an acceptable rate. Thus the linen becomes crisp and smooth again. Bedroom Interior Design Ideas. If you enjoy the feeling to be cocooned, bed drapes are for you. Whether emanating from the corona, half-tester or full tester, they offer an incredibly secure, enclosed feeling and look extremely attractive in to the bargain. Always devote careful thought to the lining of any such bed treatment as that is what will be most often seen by the person lying in bed. An inferior repeat of the facial skin fabric pattern can make a very pleasing result, as can the utilization of ticking fabric in a coordinating color.
Can i shorten the posts on my bed ideas from stanley bedroom furniture , source:pinterest.com, Author: Koncobolo
Introduce various lighting option. It's recommended to layer your lighting in your bedroom. Ambient lighting often light the entire room. Small lamps to focus light for different activities like reading etc. Accent light aids in washing the four walls within soft illumination. Place the reading light at the bedside; within reach these lights should have adjustable dimmer. All you need to have is a wide comprehension of colors and image of how your bedroom would look like. Dark colored walls will make the room look smaller and light colors would add more space to your room.
Transitional Bedroom Set By Stanley Furniture


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Introduction to Residential Layout
Routledge, Mar 30, 2007 - Architecture - 256 pages
Introduction to Residential Layout is ideal for students and practitioners of urban design, planning, engineering, architecture and landscape seeking a comprehensive guide to the theory and practice of designing and laying out residential areas.
Mike Biddulph provides a clear and coherent framework from which he offers comprehensive practical advice for designers of housing developments. Referring to a wealth of international examples, this is a richly illustrated, accessible resource covering the whole range of issues that should be considered by
anyone engaging in the planning and design of a new residential scheme.
A successful residential development must work on many levels – financial, social and environmental. This book includes analysis of commercial viability, the importance of place making, environmental sustainability and designing accessibility. Mike Biddulph details successful approaches to designing out crime and maximising permeability as part of an integrated approach to urban design.
Highly illustrated throughout, this work will show you how to turn design aspirations and principles into practical design solutions. Written without preconceptions, Introduction to Residential Design
highlights the strengths and weaknesses of particular design solutions to encourage both depth of thought and creativity.
Mike Biddulph is Senior Lecturer in Urban Design at Cardiff University
What people are saying - Write a review
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2 Ensuring commercial viability
3 Building place and defining space
4 Environmentally benign development and design
5 Access and movement
6 Integrating other uses
7 Safe and easy to find your way around
8 Contemporary residential townscape
9 Social life in outdoor residential spaces
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Common terms and phrases
accommodate achieved activity allow amenity apartments bed house Type biodiversity block structure buildings car parking carriageway catchment centre Chapter character commercial consider courtyards create cul-de-sacs cycle Department for Transport distance distinctive drive encourage ensure environmental example fa�ades facilities feel Franz�sisches Viertel front gardens frontage garages green spaces grid higher density highway home zone impact important junctions land landscape layout live located neighbourhood neighbouring open spaces Orenco Station outdoor spaces parking courts particular passing trade pattern of access pedestrians and cyclists periphery block permeable planning planting play Pontprennau Poundbury private gardens public realm public spaces public transport Radburn reduce resi residential areas residential schemes residents result Rieselfeld roads semi-private shops social space Figure standards street furniture surfaces surveillance townscape traffic calming trees typically units per hectare urban areas urban design urban environment urban form urbanist vehicles vehicular views visual whilst


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|This item may be available for custom order in store or online. Custom orders may take up to 1-3 weeks. Please contact us for more information.
|Delivery time:
|Custom orders may take 1-3 weeks to be delivered to the store. Contact us for availability (504-407-2700) or email@example.com
We will match verified competitor prices on this product.
The BOB B-Safe 35 by Britax combines unmatched protection with distinctive BOB style. BOB owners rejoice – Britax, the #1 brand in safety technology, has an infant car seat just for you. With just an adapter (sold separately), you can create the perfect BOB travel system.
The BOB B-Safe 35 Infant Car Seat should only be used in a rear-facing position when using it in the vehicle.


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Afilador Cerro Bilanero 3D Model
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Afilador en piedra moliz encontrado en el Cerro Bilanero, campaña 2015 (Alhambra, Ciudad Real).
February 10th 2016


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How Many People Suffer From Depression Worldwide?
Updated June 28, 2019
Depression is a pandemic that affects countless people's quality of life. Although rates for the condition are at an all-time high overall, certain regions and groups of people have higher rates of depression than others, which makes studying various demographics crucial. In this article, you will not only learn about depression statistics in America but statistics regarding gender, age, and different countries across the world as well. The article will also be providing you with a bigger picture on this issue.
Source: pixabay
Why Is Depression Prevalent?
Depression can happen for numerous reasons. People can become depressed following the death of a loved one or the breakup of a relationship, and in many cases, the sadness can often pass with enough time.
However, depression can also be chronic and may need to be treated with medication, lifestyle changes, therapy, or a combination of all three.
A depressive state that persists for most of the day and for at least two weeks is known as major depression or clinical depression, and it can severely affect an individual's ability to function properly. If these symptoms last longer than two years, it is known as persistent depressive disorder or dysthymia. Symptoms may be harsher on some days than others. [1]
Additionally, there are forms of depression that are still common but circumstantial. For instance, post-partum depression can occur following a woman's pregnancy, and seasonal affective disorder can happen during dark and cold seasons.
Therefore, depression is a broad umbrella term that can refer to specific conditions with very similar signs and symptoms.
While depression can be a response to a life event, it can also be caused by genetics, biological, environmental, and other psychological factors. [1] In other words, some people may have specific reasons for being depressed, such as being impoverished, while others can be depressed because of brain chemistry (i.e., serotonin levels).
Depression also affects people differently - not everyone will have the same set of symptoms, and this greatly contributes to its diversity. The condition, while there are core indicators of it, can take different forms and present itself in a variety of ways.
Additionally, some cultures may be less keen on discussing depression, and people may have a tendency to try to hide it, which can make the condition deceptive. For instance, depression in the United States, or North America in general, might be more readily talked about than in South America.
Depression In Men Vs. Women
Depression does not discriminate based on biological sex or gender; however, the percentage of people with depression is much higher in women than men.
Globally, the prevalence for women is around 5.5 percent whereas for men it is 3.2 percent. These values mean that women are 1.7 times more likely to have depression than men. [2] This is just an average, and some specific places can have larger ratios between the two genders or higher prevalence overall.
For example, depression rates in America show significantly higher values, and in 2017, US depression statistics estimated that in adults, females had a prevalence of 8.2 percent compared to 5.3 percent in men. Out of the entire population, approximately 17.3 million people had experienced a depressive episode that year, or 7.1 percent of all adults. [3]
While socioeconomic factors, like education and income, can play a role in this disparity, researchers have been highly interested in biological factors that can cause it.
One of the main triggers for depression in women is hormonal changes which can fluctuate during puberty, pregnancy, and menopause. Women can experience specific types of depression related to this, such as premenstrual dysphoric disorder, post-partum depression, and post-menopausal depression. [2]
Source: pixabay
Hormonal changes can also explain why boys are statistically equal or more likely to have clinical depression than girls prior to puberty. However, after this time, depression in boys usually stabilizes, whereas it increases dramatically in girls. [2] [4]
Importantly, the topic of hormones also indicate that the discrepancy between males and females does not apply just to the prevalence of depression in the US; instead, it would be relevant everywhere.
Depression In Different Age Groups
Age has an impact on depression rates and it primarily begins during adolescence, typically around 12 years of age.
In the previous section, the age issue was briefly touched upon, and boys essentially have equal footing with girls regarding the issue. Starting at puberty, young females around the world have the greatest risk for mental health issues, including depression.
Significant hormonal differences are primary factors, and specifically estrogen and its cycling have been implicated in the higher depression rates in females.
In 2017, adolescent depression statistics estimated that 3.2 million individuals ranging from the age of 12 to 17 had experienced an episode of major depression, accounting for 13.3 percent of the United States' population. Males accounted for 6.8 percent of this value, whereas females were 20 percent. [3]
Depression is also a significant concern for college-aged individuals, and approximately 10 percent of people were diagnosed or treated for it. Depression in college students statistics also note that depression and anxiety are the top barriers to academic performance, and around 31 percent felt that they had difficulties functioning properly. Unfortunately, 64 percent of young adults stop attending college or university entirely because of mental health issues like depression. [5]
Despite there being strong statistical differences between males and females, and depression peaking during the ages of 45 and 64, it eventually evens out. Overall, depression usually declines after the age of 65, returning to similar ratios prior to puberty. [2] [6]
Nonetheless, there may also be generational stigmas regarding mental illness amongst all older individuals, and therefore, may be underreported. For instance, one might not fully acknowledge their depression and seek help to avoid feeling like he or she is crazy.
These types of stigmas can also account for some of the variations regarding stats about depression in different cultures as well.
Global Depression Statistics
According to a study from 2017, approximately 322 million people have depression. This equates to roughly 4.4 percent of the world's population. These depression rates over time have continued to increase, especially in low-to-middle income nations. [7]
This makes it one of the leading causes of disability around the world, along with anxiety.
When comparing continents to one another, South America has the highest overall prevalence at 20.6 percent. Asia sits at 16.7, North America at 13.4, Europe at 11.9, and Africa at 11.5 percent. [8]
One of the main contributors of depression in Latin American and Carribean countries is poverty, and with a significant portion of the population struggling with mental health issues, this hurts productivity. Depression can hamper one's ability to work, and without access to adequate health care, it can go uncontrolled, become an epidemic, and slow down development.
However, in this region, there are stigmas regarding mental health, and many people are ashamed to seek help if it is available. The mentally ill have also faced discrimination, as well. [9] Therefore, education is required to destigmatize mental health, get people treated, along with addressing poverty.
Source: pixabay
While poverty is a significant issue, it is not necessarily always the cause of depression in other regions. The prevalence in countries with high and very high HDI (Human Development Index) are 9.8 and 19.2, respectively. [8]
Another related issue to how many people are affected by depression is suicide, and many developed countries experience extremely high rates of this. It is estimated that 50 percent of all suicides are associated with depression. [10]
One of the leaders of economic growth during the last half of a century, South Korea has one of the highest suicide rates in the world, and as of 2011, 6.7 percent of the country's population experienced depression; however, since it has consistently risen, this value is expected to be higher nowadays. [10]
Japan also has experienced similar statistics, and from 1996 to 2012, approximately 20 per 100,000 people died from suicide. Most notably, in 1998, it peaked at 50 per 100,000 individuals. [11]
In Japan and South Korea, education levels are a major contributor to how many people are depressed. Those with higher education and advanced degrees are associated with better, more stable occupations, and therefore, more respect in their societies. Because of this, those with lower educational levels have an increased risk of suicide. [11]
Contrary to this, higher education is also a source of significant stress in these societies. Depression in college students statistics for Japan reports that 43.8 percent of men and 40.9 percent of women at the university level have high perceived mental stress and many of them smoke and drink alcohol to cope with it.
Even worse, many young men and women resort to suicide to escape the stress from university and professional lives.
Nonetheless, while poverty can, without a doubt, cause depression, these statistics demonstrate it can affect people in upper-income brackets, hence, its prevalence amongst university students and professionals in highly-developed nations. Regardless of socioeconomic status, no one can be completely immune to the condition and have various reasons to be depressed.
Depression can manifest itself in several different ways and have many causes, and people might form their own beliefs about the condition, but global depression rates indicate that this is a serious public health concern in every region.
Through education, destigmatizing mental illness, and providing access to affordable and mental health services, depression can be fought, and its impact on societies can be reduced by creating happier and more productive citizens.
BetterHelp.com is committed to educating people on all mental health issues, and if you are experiencing depression, help is available to you. BetterHelp cannot prescribe antidepressants, but quality counseling and therapy services from licensed professionals are available online when you need them.
Source: pixabay
Hopefully, this article has given you a clearer picture of not only what the condition looks like in America but also how many people suffer from depression on a global scale. The stats about depression are staggering and have been on a rising trend, but with the right approach and attitudes from individuals with the condition and society as a whole, it can be helped.
How many people suffer from depression
- National Institute of Mental Health. (2016). Depression Basics. Retrieved May 24, 2019, from https://www.nimh.nih.gov/health/publications/depression/index.shtml
- Albert, P. (2015). Why is depression more prevalent in women? Journal of Psychiatry & Neuroscience, 40(4), 219-221. doi:10.1503/jpn.150205
- National Institute of Mental Health. (2019). Major Depression. Retrieved May 24, 2019, from https://www.nimh.nih.gov/health/statistics/major-depression.shtml
- Abate, K. H. (2013). Gender Disparity In Prevalence Of Depression Among Patient Population: A Systematic Review. Ethiopian Journal of Health Sciences, 23(3). doi:10.4314/ejhs.v23i3.11
- Chadron State College. (n.d.). College Student Mental Health Statistics. Retrieved May 25, 2019, from https://www.csc.edu/bit/resources/statistics/
- Watson, S. (2015, October 30). Recognizing the "unusual" signs of depression. Retrieved from https://www.health.harvard.edu/blog/recognizing-the-unusual-signs-of-depression-201302275938
- Friedrich, M. (2017). Depression Is the Leading Cause of Disability Around the World [Abstract]. Jama, 317(15), 1517. doi:10.1001/jama.2017.3826
- Lim, G. Y., Tam, W. W., Lu, Y., Ho, C. S., Zhang, M. W., & Ho, R. C. (2018). Prevalence of Depression in the Community from 30 Countries between 1994 and 2014. Scientific Reports, 8(1). doi:10.1038/s41598-018-21243-x
- Poor mental health, an obstacle to development in Latin America. (2015, July 13). Retrieved May 25, 2019, from http://www.worldbank.org/en/news/feature/2015/07/13/bad-mental-health-obstacle-development-latin-america
- Koo, S. K. (2018). Depression Status in Korea. Osong Public Health and Research Perspectives, 9(4), 141-142. doi:10.24171/j.phrp.2018.9.4.01
- Kimura, T., Iso, H., Honjo, K., Ikehara, S., Sawada, N., Iwasaki, M., & Tsugane, S. (2016). Educational Levels and Risk of Suicide in Japan: The Japan Public Health Center Study (JPHC) Cohort I. Journal of Epidemiology, 26(6), 315-321. doi:10.2188/jea.je20140253


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Election News
Mayor Pete wouldn't be allowed to work at his own high school because he's gay
The high school Pete Buttigieg went to refuses to hire men who are in relationships with another man.
News (USA)
Vandals tear down signs for a high school's LGBTQ-support group twice in 1 week
Students reportedly cheered and applauded as one of the signs was trashed during lunchtime.
LGBTQ History
Do you know the history behind LGBT History Month?
Why is it in October?
News (USA)
Two high school coaches suspended over an LGBTQ charity basketball game
Was it really about paperwork or was it homophobia?
News (USA)
Scandal star Kerry Washington eviscerates Trump during award acceptance speech
"We've gone from a White House lit in all the colors of pride to a White House that literally preaches division and discrimination."
News (USA)
After queer students were bullied by Trumpers during Homecoming, this town wasn't having it
The students were left in tears after being pelted with candy as the crowd chanted "Make America straight again" during a homecoming parade.
News (USA)
Can states work around Trump to protect transgender students?
The administration rescinded a directive instructing public schools to allow students to use the bathrooms and locker rooms matching their gender identity.
News (USA)
Julia Roberts stands by transgender teen: 'I want all students to feel safe'
The Hollywood star has a message for transgender students nationwide: "You are loved."
News (USA)
Trump grants antigay clergy 'free speech & religious liberty' protections
The president declared he's directed the Department of Justice to "develop new rules" to ensure religious free speech.
News (USA)
Adult behavior sets a deadly example for youth by encouraging bullying
Cyber-bullying is a pervasive threat to the well-being of LGBTQ youth.


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QATSIF QCE Scholarships - Applications open now
Brisbane 24th June 2019:
The Queensland Aboriginal and Torres Strait Islander Foundation (QATSIF) has just opened its 11th Round of scholarships to assist Queensland Aboriginal and Torres Strait Islander students to complete Years 11 and 12.
QATSIF is a charitable trust which was first established in 2009 to ensure that any interest from unspent Indigenous wage reparation money is made available to help Indigenous young people.
Across its first 10 years, QATSIF has awarded over 8,700 QATSIF QCE Scholarships to young Aboriginal and Torres Strait Islander Queenslanders in 300 secondary schools throughout Queensland.
Amongst many outstanding young Indigenous leaders, QATSIF is proud to have supported:
the Highest Achieving Aboriginal and Torres Strait Islander Students in Queensland over three of the past four years.
2019 Queensland Music Award winners: Emily Wurramara and Tia Gostelow.
2019 First Nations Law Student of the Year.
2019 Seven News Young Achiever – Aboriginal Achievement award.
2019 Exceptional Indigenous Queensland Minerals Energy Academy Student.
many outstanding Indigenous role models, including: Jemma Mi Mi (Qld Firebirds), Clay Waterman (Commonwealth Games Bronze medal boxer); Kitara Whap-Farrar (Gold Coast Suns) and Akayla McQuire (Indigenous Women's All Stars).
QATSIF recognises the vital role that successful completion of schooling and the availability of opportunities have in building a foundation for employment, further education and better quality of life.
Aunty Ruth Hegarty, QATSIF's Patron, author and Stolen Wages campaigner encourages Aboriginal and Torres Strait Islander young people to make the most of this opportunity which her and other Elders were denied, "Go Forward! Our reward is to see you succeed in whatever profession you choose. Our trust is in you, the very future of giving of yourselves to be a beacon of hope for future scholars."
Under the QCE Scholarship Program, QATSIF provides two-year scholarship funding to support students to gain their Queensland Certificate of Education (QCE) across Years 11 and 12.
Current Year 10 and 11 Aboriginal and Torres Strait Islander students can apply for a 2020 QATSIF QCE Scholarship through their schools.
For Further Media Information Contact :
Michael Nayler
QATSIF Secretariat Director
Phone: 07 32571777
Email: email@example.com


text: this chest is really nice and sturdy. it will last for years to come. the whole thing is made of wood except for the bottom which is MDF. i called the company and they assured me that the mdf is made from nontoxic glue. its pretty big it fits me and my daughter at story time. i got a lot of pieces from little colorado and they are all excellent.


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Candy Crush Saga – a success story
Released by game developer King in April 2012, Candy Crush Saga is the most popular Facebook game, with millions of users from all over the world. Even though it was released almost two years ago, this game continues to surprise its players with constant new developments and levels. The concept of this game is fairly simple: mix and match same-colored candies to obtain as many points as possible. However, players are always surprised to discover the latest changes and updates of this wonderful game. The game developers did a really good job to create a colorful and happy world, where people of all ages can play and have fun. Candy Cush has become so popular that there is an entire industry following it. Many people are now ordering custom made cakes and pastry to match the colorful candy from this game or offer their friends clothes printed with images from Candy Crush. The main reason why this game has maintained its popularity over time and managed to gather so many players is because it continues to offers them various challenges and interesting levels. The internet is filled with Candy Crush Saga cheats even though most of them are just advice on what you can do to pass a level easier.
Even though most games of this kind fade out after about one year of their release, Candy Crush continues to heat conversations between players about various levels challenges, how to obtain the best possible combination and useful Candy Crush Saga cheats. Moreover, the game makers are always preparing something for the fans of this game to maintain their interest and continue to have fun playing it. Recently, there has been a development in the game, where players can enter an alternate land called Dreamworld and begin a new set of levels with fresh challenges. Of course, the idea of the game is the same, to mix and match same colored candies to obtain as many points and combinations as possible. But the player has to keep an eye on many other variables and thus it becomes increasingly more challenging. This game has received a particular attention from media all over the world, especially in Hong Kong, where reportedly one seventh of the population plays it. Furthermore, this game has reached the top 50 most downloaded Facebook games in the world in December 2013 and continues to rise permanently.
Last but not least, one cannot deny that Candy Crush Saga is an incredible success among people from all over the world and of all ages. With permanent updates and new challenges, this game continues to maintain and enhance its popularity as time goes by. There are very few people who can say they have not played this game at least once or seen one of their friends playing it. The team behind this game really had a stroke of genius when they came up with the concept of Candy Crush. Even though, at first, it seemed like another match-three game players are so tired of, this game managed to capture the attention of everybody and create in a very short time, one of the largest networks of players on the internet.


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2018 has been marked by growth, both personally and professionally, with so many fun projects and lessons learned along the way. As the year comes to a close, I want to share with you some of my reflections on the year, personal highlights, and a sneak peek of what's to come in 2019!Read More
There's always a client or project more important than working on "internal" items. But the thing is, those internal items are what get the projects and clients. They should have just as much priority as some of that client work if you want to keep the ball rolling on your business.Read More
Something I learned pretty darn quickly running my business is that I had to trust my gut and trust my abilities since there is literally no one else to give second eyes or opinions…Read More
There's a lot out there about having saying "YES!" to everything in your first year of business, but there's not a lot out there about it being okay to say "No" once in a while...Read More
Naming your business is always something that takes more time than you'd think and is also much more difficult than you'd think. It's hard to capture everything you want to say to your customers in one word. Here are a few things to keep in mind when coming up with your business name...Read More


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The irrepressible Phyllis Schlafly turned 80 this weekend. Her influence on grass-roots conservatism is profound. And she remains as incisive and impassioned and prolific as ever. Her latest of 20 ground-breaking books is The Supremacists: The Tyranny Of Judges And How To Stop It, but the one we're reading now in the Malkin household is the fantastic First Reader, Mrs. Schlafly's phonics system, which we're using to teach our four-year-old to read.
A Washington Times feature about Mrs. Schlafly's birthday celebration included the following quote:
Asked to name the greatest accomplishment of her life, she didn't hesitate a moment before replying, "My six wonderful children."
God bless her.
Nancy Pelosi calls GOP tax cuts 'pathetic' but she's actually describing the collapsed Dem narrative
January 11, 2018 06:10 PM by Doug Powers
Uh oh, that tax bill 'Armageddon' Nancy Pelosi warned about is kicking in!
January 6, 2018 03:49 PM by Doug Powers
Attn. Nancy Pelosi! CBS News finds families who WON'T be killed by the tax bill
December 22, 2017 08:27 PM by Doug Powers
GOP tax bill causes Nancy Pelosi to lose remaining fragment of her mind
December 20, 2017 07:56 AM by Doug Powers
Newsweek wants you to meet the Pence family — Serial pet killers
December 8, 2017 02:38 PM by Doug Powers
Categories: GOP, Media, Media Bias


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A large part of me saying this has to do with a conversation I had a with a friend recently that went like this:
"I am telling you there is an invisible and undetectable purple elephant in this room"
"I don't believe you prove it!"
"No, you have to prove it is not there"
Now in this scenario does it seem more logical for me to say there is no evidence of the elephant existing and I have reason to believe the elephant does not exist, therefore it does not exist. Or for me to say there is no logical reason to believe that the elephant does exist but I can't prove it does or doesn't exist through testing therefore it might exist.
I am not saying I would refuse to believe something were there evidence, so if it were proven today that God exists then of course I would accept the fact. But no such evidence exists.


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Category Archives: Cooking and Food
Do You Mind Playing in Severe Cold?
I'm marking today as the day we hit "peak January" here in New England. We are tired of hearing our furnaces run, the late December ice deposits are impervious to salt and calcium chloride, and a winter storm is sending … Continue reading
The Lutheran Binder
A few weeks ago, on October 15, 92-year-old Dorcas Reilly died. Never a household name in her lifetime, Reilly's fame will live on in a simple and heartwarming recipe she created in 1955. While working in the Campbell's Soup test … Continue reading
A Day in Town
The Maine Historical Society's current exhibit, Maine Eats: The Food Revolution Starts Here, opened on March 2, 2018. As an occasional food writer, I have longed for a spare minute to see this exhibit. I e-mailed a Southern Maine friend … Continue reading
Searching for Mrs. Shockley
One of my Basilica research destinations was the Androscoggin Historical Society. The AHS have a large collection of Lewiston's now-defunct Evening Journal, bound periodical-style. They're dusty and dirty and still have the faint feel of newsprint about them. During one … Continue reading
The House of Big Salads
On April 28, the Pickwick Club, Maine's only Charles Dickens reading club, will reconvene to discuss Jenny Hartley's book Charles Dickens and the House of Fallen Women. Perhaps you don't know a lot about Mr. Dickens, other than the omnipresent … Continue reading


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As the third movie in Christopher Nolan's take on the Batman franchise receives a hotly anticipated release date, superhero fans are no doubt fervently pencilling July 20th 2012 into their calendar's in excitement. With the just the tentative title 'Batman 3', and the film's lack of a plot, villain or script, comic book fans can amuse themselves in the meantime with our run-down of top batman fancy dress costumes.
Batman- The caped crusader has taken on a vast number of guises over the years, from Adam West's tongue in cheek portrayal in the 1960's, to the slightly wooden incarnations played by Val Kilmer and George Clooney, and the most recent hoarse throated buffed up Batman look of Christian Bale. Each had a slightly different costume, with Adam West's grey and black number resembling something from a school play.
The Joker- A superhero is of course nothing without his nemesis, and The Joker, most recently played by the late great Heath Ledger, is perhaps one of the most iconic villains ever to grace the silver screen. For your fancy dress costume you'll need a purple blazer with clashing green shirt, and of course a healthy smattering of red and white face paint.
The Riddler- Along with a touch of insanity and a mischievous nature, The Riddler's main distinguishing features are a bright green bodysuit covered in question marks and glaring ginger hair. Very inconspicuous.
The Penguin- Portrayed in Batman Returns by Danny DeVito, The Penguin's bird-like webbed hands earned him his nickname. A top hat, circus-master suit and cane are essential for this distinctive fancy dress costume.