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Amanda Chan
MyHealthNewsDaily Staff Writer
LiveScience.com Amanda Chan
myhealthnewsdaily Staff Writer
livescience.com – Tue Nov 2, 2:02 pm ET
Compounds found in black raspberries are effective in preventing colorectal cancer tumors in mice, according to a new study.
The fruits contain compounds called anthocyanins, which give them their color, along with a host of other cancer-fighting vitamins, minerals and acids, said study researcher Gary Stoner, a professor at the College of Medicine at the Ohio State University.
"Due to the high levels of these compounds, the berries have high antioxidant activity," Stoner told MyHealthNewsDaily. He added that it makes them effective in destroying toxic free radicals in the body, which can damage DNA in cells.
If the same result is found in humans, the fruit could be used to help prevent colorectal cancer. Previous studies have found black raspberries - which are different from blackberries - to play a role in preventing esophageal, oral and skin cancers, he said.
Ripe results
Researchers genetically engineered two types of mice to test the benefits of black raspberries. One type was engineered to develop intestinal tumors, and the other type was engineered to have colitis, an inflammation of the large intestine that can lead to colorectal cancer.
For 12 weeks, all mice were fed a "high-risk" diet - which was high in fat and low in calcium and vitamin D - and some were also given a supplement, so 10 percent of their calories came from freeze-dried black raspberry powder.
Both types of mice that ate the black raspberry powder had fewer tumors than the mice not given the supplements.
Among mice engineered to have intestinal tumors, the growth of new tumors decreased by 45 percent, and the total number of tumors in the mice decreased by 60 percent, the study said. The black raspberries stopped tumors from developing by suppressing a protein that binds to the gene that the scientists genetically modified in the mice, the researchers said.
In the mice engineered to have the intestinal inflammation, new tumors and number of tumors were reduced by 50 percent, because the black raspberries worked to reduce inflammation, according to the study.
To get the equivalent of the supplements the researchers gave the mice, a human would have to eat four cups of fresh berries a day, said study researcher Dr. Wancai Yang, an assistant professor at the University of Illinois at Chicago.
That's a lot for humans, but the animals used in the study were engineered to be susceptible to cancer. So for humans, "it is not necessary to eat so much fresh berries to have similar benefit of cancer prevention," he said.
Findings for fruit
Other berries, such as blueberries and strawberries, are also known to have cancer-preventing effects, but their effects are not as great as those of black raspberries, Yang said.
A 2001 study by Stoner in the journal Carcinogenesis found freeze-dried berries stopped the changes that take place cells and lead to cancer. The study used animal cells grown in lab dishes.
And two 2009 studies - one conducted in cells in lab dishes and one conducted in mice - found that compounds in black raspberries can prevent and stop proliferation of esophageal tumor cells. The studies were published in the journals Nutrition and Cancer and Cancer Prevention Research.
Because the black raspberries were shown to lower inflammation, it's possible that they can also protect against other diseases, such as heart diseases, the researchers said.
The new study was published in the November issue of the journal Cancer Prevention Research. The work was funded by UIC and the National Cancer Institute.
- 10 Dos and Don'ts to Reduce Your Risk of Cancer
- 5 Lifestyle Tips That Lower Your Risk of Colorectal Cancer
- Colon Cancer: Causes, Symptoms and Treatments
This article was provided by MyHealthNewsDaily, a sister site to LiveScience.
- Original Story: Black Raspberries Help Prevent Colorectal Cancer in Mice
LiveScience.com chronicles the daily advances and innovations made in science and technology. We take on the misconceptions that often pop up around scientific discoveries and deliver short, provocative explanations with a certain wit and style. Check out our science videos, Trivia & Quizzes and Top 10s. Join our community to debate hot-button issues like stem cells, climate change and evolution. You can also sign up for free newsletters, register for RSS feeds and get cool gadgets at the LiveScience Store.
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text:
Posted February 6th, 2013 in Uncategorized
Great Lakes levels have been significantly lower than average for months now, and much of the blame for the record or near-record lows was seen in last year's extensive drought. However, other possible causes for the continued low levels of the lakes are being investigated, including dredging and river bed mining.
From The Grand Haven Tribune:
"Findings recently released by the Georgian Bay Association indicate the decline in levels in Lakes Michigan and Huron is tied to American and Canadian navigational channel dredging, river bed mining and shoreline alteration projects near Port Huron and Sarnia, Ontario.
The association's report says more than 2 billion gallons of water a day flows out of the St. Clair River — or more than 3,000 Olympic-size swimming pools. All of this water eventually ends up flowing over Niagara Falls and out to the Atlantic Ocean."
The article, linked above, goes on to discuss the struggle to find a middle ground between navigational needs and maintaining lake levels.

subset: commoncrawl


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Well, I'm happy and sad to say that my typescript has been scanned. Part of the story incorporates collage (by my girlfriend), notations (by a character), and poetry (hers and his). I slipped a lot of forensic elements into the story, too. For example, this shift key on the typewriter does not work when she initially uses the SG1. This changed the way I typed her parts. Eliezane wrote the poetry for the female character. Stylistic differences will be evident. Finally, my last creative flourish was to rip the edges of the male character's poems and to smudge them with an ink pad. I hope the reason will be clear. Others have better expressed the experience of writing for Cold Hard Type. It was an experience of organic craftsmanship, capturing the intent of the book. Sure, the story has to be scanned in the end, but that's making the best of all tech. I think Joe Van Cleave said something about the physics of the process–moving from biological and mechanical effort to digital product. The whole thing represents a stratified yet unified transformation.
Now, alas, it is time to get back to grading.


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New Contemporaries 70th Anniversary Two-Day Programme in collaboration with The Courtauld Institute of Art
Book your tickets here
Marking our 70th anniversary this year, New Contemporaries will celebrate its legacy and future direction with a two-day conference with The Research Forum, Courtauld Institute of Art in London. Contributors include Erika Balsom (academic and critic), Leah Capaldi (artist), Mike Collier (writer and curator), Sacha Craddock (writer and curator), Adham Faramawy (artist), Ryan Gander (artist), Sunil Gupta (artist and curator), Lawrence Lek (artist), Alistair MacLennan (artist), Haroon Mirza (artist) and Elaine Shemilt (artist and academic).
Collaborating with The Research Forum at the Courtauld, the conference programme will address the development of New Contemporaries as it continually evolves to support the needs of emerging artists and practices. Established in 1949, New Contemporaries, formerly Young Contemporaries, is the longest-running support platform for emerging artists.
The programme will explore different aspects of representation and visibility for emerging arts, bringing into dialogue artists, curators, writers and art works from New Contemporaries history alongside contributors drawn from the Courtauld's own alumni network of curators, artists and historians. Both days will include panel discussions, Q&As and artists' presentations.
Day 1 will explore notions of diversity and gender politics in the UK's art scene, along with definitions of the contemporary. Panel discussions will consider globalisation, identity and the difficulty in defining new artistic tendencies as well as what agency performance art still holds as an artistic medium.
Day 2 will focus on the future of artistic practice and the responses needed to support its continual evolution. Sessions will discuss new artwork platforms, how conventional forms of exhibition making are evolving, opportunities for artistic collaboration, and new and necessary funding models for artists.
The Courtauld conference is part of an ambitious public programme of events for New Contemporaries 70th anniversary comprising exhibitions, talks, symposia and workshops, as well as contributions from alumni in the form of performances, commissions and filmed interviews.
The Research Forum, The Courtauld Institute of Art
Vernon Square, Penton Rise
Kings Cross
Previous EventModernism: A Sentimental Myth
Next EventNew Contemporaries Archive Films


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text:
I manage lot of router and switch my problem is before I do any changes to configuration file I want to save a copy of it
if I do sh run using putty it just displays one page worth of information and I have to do copy paste one page at a time
is there any easier method to copy paste entire running config to a text file ?
Hello Manish,
enable session> logging in putty using connection properties
term len 0
sh run
in this way all the file is placed without need to press for next page
then you stop logging and you have your file.
to have again pages type:
term len 25
putty saves an header with date and time at the beginning after that you have clean text file.
Hope to help
This worked very well
Thank you for the information, Giuseppe - it was precisely what I needed (5 years after you posted it :).
Thank you Giuseppe Larosa !! - by far the easiest and fastest solution I've seen so far. No need to set up TFTP or copying and pasting all over the show. You have saved me a lot of time today
Unfortunately, the command term len 0 didn't work for me on an ASA 5516x. I had to do the following, after turning on logging in Putty:
config t
pager line 1000
sh run
pager line 24
This puts the ASA into enable mode, config terminal mode, sets the number of lines between page breaks to 1000, runs the show running config and then resets the number of lines back to 24. It worked well for me!
Another option would be to send either the startup or running config to a TFTP, FTP or RCP server. The file will be text, although believe sequence of LFCR confuses Windows' Notepad but Wordpad renders it correctly.
If you use secure crt
go to file then click on log session then save the file with .txt extension
thay way your config file will be saved in text format
hope that helps
You can tray to use this commande :
Router# terminal length 0
You can tray to use this commande :
Router# terminal length 0
You can also use the following command from command prompt:
telnet -f fileName.txt x.x.x.x(IP)
Now everything that you do during this telnet session will be recorded in fileName.txt.
Hello MKCHAURASIA,
If you are wondering how to copy your save running-config to a text file, my best suggestion would be to copy the outcome of the command line (via the CLI) and then open notepad and past the config there. Afterward, you can obviously save it to the desired folder!
Hope this helps!
Best regards,
I am looking for an equivalent command to "show running | file $fn" in XML on IOS XR routers.
The command or steps I am looking for will help me save a running config in xml format to a file
on the router.


text:
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text:
Pharmacy opening hours information
May Bank Holidays in London: Pharmacy opening hours
Pharmacists can advise you on a range of minor medical issues like sore throats, coughs and colds, tummy troubles and emergency contraception. Seeing a pharmacist is often the best first step for minor health concerns, and they can provide one-to-one, confidential consultations. A list of pharmacies that are open on the Bank Holidays in May 2019 is available here:
London pharmacy opening hours for May Bank Holidays 2019
If you need medical help fast, but it's not a life-threatening situation, call NHS 111. In an emergency, you should dial 999 or go to A&E.
Patients experiencing dental pain are advised to call NHS 111 in the first instance, who will transfer the call to Londonwide Dental Nurse Triage service. A dental nurse will ring the patient back and, if deemed appropriate, the patient will be referred to a dentist for urgent dental treatment. In most cases this will be to a practice close to where the patient lives although, in some circumstances, patients may need to travel further depending on their location and what time of the day or night they ring.


text:
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Ralph Lauren launches polotech smartshirt with groundbreaking adaptive workout app
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Related Articles
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text:
Aug 22, 2019 (Heraldkeepers) -- New York, August 22, 2019: Immunotherapy refers to treatments that stimulate, beautify or suppress the body's personal immune system. Cancer segment is additionally anticipated that would be the quickest developing section in the market, by treatment. The vast share and high development of this section can be credited to component, for example, high inclination for immunotherapy as a first line of treatment in disease prompting to developing interest for immunotherapy drugs. The rising open doors in the developing markets and immunotherapy as a contrasting option to chemotherapy for first line treatment are the variables supporting the development of the market. The high development of this portion can be ascribed to elements, for example, expanding selection of checkpoint inhibitors in tumor treatment with their capacity to target just outside cells leaving typical cells alone. Adult antibodies fragment is further sorted into preventive immunizations and helpful immunizations. The high development of this portion can basically be ascribed to the ease of assembling and worthy administrative situation in this locale.
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The Immunotherapy Drugs Market is expected to exceed more than US$ 289.52 Billion by 2024 at a CAGR of 13% in the given forecast period.
The report covers detailed competitive outlook including the market share and company profiles of the key participants operating in the global market. Key players profiled in the report include GlaxoSmithKline (U.K.), AbbVie, Inc. (U.S.), F. Hoffmann-La Roche AG (Switzerland), Amgen, Inc. (U.S.), AstraZeneca plc (U.K.), Bristol-Myers Squibb (U.S.), Novartis International AG (Switzerland), Eli Lilly and Company (U.S.), Johnson & Johnson (U.S.), and Merck & Co., Inc. (U.S.). Company profile includes assign such as company summary, financial summary, business strategy and planning, SWOT analysis and current developments.
This report provides:
1) An overview of the global market for Immunotherapy Drugs Market and related technologies.
2) Analyses of global market trends, with data from 2015, estimates for 2016 and 2017, and projections of compound annual growth rates (CAGRs) through 2024.
3) Identifications of new market opportunities and targeted promotional plans for Immunotherapy Drugs Market.
4) Discussion of research and development, and the demand for new products and new applications.
5) Comprehensive company profiles of major players in the industry.
The Immunotherapy Drugs Market has been segmented as below: (Accordingly)
The Immunotherapy Drugs Market is Segmented on the lines of Type of Drugs Analysis, Therapy Area Analysis and Regional Analysis. By Type of Drugs Analysis this market is segmented on the basis of Monoclonal Antibodies, Adult Vaccines its covers Preventive Vaccines & Therapeutic Vaccines. Checkpoint Inhibitors, Interferons Alpha & Beta, Interleukins And Others.
By Therapy Area Analysis this market is segmented on the basis of Cancer its covers Solid Tumor & Malignant. Autoimmune & Inflammatory Diseases, Infectious Diseases And Others. By Regional Analysis this market is segmented on the basis of North America, Europe, Asia-Pacific and Rest of the World.
The major driving factors of Immunotherapy Drugs Market are as follows:
- Increasing selection of focused treatments with less symptoms
- Quicker medication endorsement forms
- High pervasiveness rate of way of life infections
The restraining factors of Nuclear Imaging Equipment Market are as follows:
- High cost of immunotherapy treatment
- Weakening rate in the item advancement cycle
Request Sample Report: https://www.marketresearchengine.com/immunotherapy-drugs-market
Table of Contents
2 Research Methodology
3 Executive Summary
4 Premium Insights
5 Market Overview
6 Industry Insights
7 Immunotherapy Drugs Market, By Type of Drug
8 Immunotherapy Drugs Market, By Therapy Area
9 Immunotherapy Drugs Market, By End User
10 Immunotherapy Drugs Market, By Region
11 Competitive Landscape
12 Company Profiles
12.1 Introduction
12.2 F. Hoffmann-La Roche AG
12.3 Merck & Co., Inc.
12.4 Novartis International AG
12.5 Johnson & Johnson (A Parent Company of Janssen Biotech, Inc.)
12.6 Glaxosmithkline PLC
12.7 Amgen Inc.
12.8 Abbvie
12.9 Astrazeneca
12.10 Bristol-Myers Squibb
12.11 ELI Lilly and Company
Other Related Market Research Reports:
In Vitro Diagnostics IVD Market Key Manufactures and Opportunity Analysis By 2024
India Sports Medicine Market is Supposed to Reach US$ 554 Million By 2022
Influenza Diagnostics Market is Expected to Exceed US$ 0.7674 Billion By 2024
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Email: email@example.com
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Website: https://www.marketresearchengine.com/
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Mesoporous bioactive glasses for controlled drug release
Mesoporous bioactive glasses for controlled drug release
Mesoporous bioactive glasses for controlled drug release
Available online at www.sciencedirect.com Microporous and Mesoporous Materials 109 (2008) 210–215 www.elsevier.com/locate/micromeso Mesoporous bioac...
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Microporous and Mesoporous Materials 109 (2008) 210–215 www.elsevier.com/locate/micromeso
Mesoporous bioactive glasses for controlled drug release Lingzhi Zhao, Xiaoxia Yan, Xufeng Zhou, Liang Zhou, Hongning Wang, Jiawei Tang, Chengzhong Yu * Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, PR China Received 23 February 2007; received in revised form 19 April 2007; accepted 19 April 2007 Available online 3 May 2007
Abstract Mesoporous bioactive glasses (MBGs) with different compositions have been prepared and their drug release behaviors have been studied. Tetracycline (TC) is selected as the model drug. It is found that TC can be successfully loaded into the mesopores; and increasing the CaO content in MBG increases the loading ratio of TC/MBG. The drug release behaviors of MBGs are also strongly dependent on their composition. MBG 100S without CaO in the framework has a rapid drug release kinetics, while MBG 90S5C, 80S15C, and 70S25C show much slow release profiles and the release constant in the first 10 h decrease as the CaO content increases. However, the release constant of MBG 60S35C is abnormally larger compared to that of MBG 90S5C. The different drug release behaviors of MBGs have been explained by their difference in CaO composition. 2007 Elsevier Inc. All rights reserved. Keywords: Mesoporous bioactive glass; Controlled release; Drug delivery; SBF (simulated body fluid); Tetracycline
1. Introduction Bioactive glasses (BGs) have attracted much attention since the first report by Hench et al. in 1971 [1]. The inorganic composition of human bone is hydroxycarbonate apatite (HCA). When implanted in human body, a HCA layer is formed on the surface of BG, which chemically bonds with living bone [2,3]. In addition to the commercial applications in bone defect repair, this family of biomaterials could be used for bioactive coating of metallic implants [4], protein and/or cell activation [5] for tissue regeneration and tissue engineering [6]. In bone reconstruction surgeries, osteomyelitis caused by bacteria infection is the main complication. Conventional treatments include systemic antibiotic administration, surgical debridement, wound drainage and implant removal. These approaches, however, are rather inefficient and the patients would suffer for extra surgeries. A new
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1387-1811/$ - see front matter 2007 Elsevier Inc. All rights reserved. doi:10.1016/j.micromeso.2007.04.041
method to solve this problem is to introduce a local drug release system into the implant site. The advantages of this treatment include high delivery efficiency, continuous action, reduced toxicity and convenience to the patients. Ordered mesoporous materials such as SBA-15 and MCM-41 have been successfully used as drug delivery systems. Their characteristics such as tunable and uniform pore size, large surface area and high pore volume make it possible to adsorb drug molecules and release them from the mesostructured matrices by a controlled rate [7,8]. However, due to the low bioactivity, pure silica cannot be directly used as bone repair substitute. Very recently, mesoporous bioactive glasses (MBGs) have been successfully synthesized and this new family of biomaterials exhibits superior bone-forming bioactivities [9–11]. Compared to conventional BGs, MBGs show different structure/composition [12] and bioactivity/composition correlations [13]. Moreover, the high pore volume as well as the uniform mesopores of MBGs makes it possible for a direct and highly efficient immobilization of proteins and/or drug molecules within MBGs, which are practically important in future medical applications.
L. Zhao et al. / Microporous and Mesoporous Materials 109 (2008) 210–215
Fig. 1. The chemical structure of tetracycline molecule.
In this work the potential of MBGs as controlled drug release system has been studied. Tetracycline (TC), a well-known broad spectrum antibiotic [14], was selected as the model drug and introduced into MBGs with different compositions to investigate the influence of composition upon the release behavior. The chemical structure of TC is shown in Fig. 1.
2. Materials and methods 2.1. Preparation of materials Nonionic triblock copolymer EO20PO70EO20 [P123, BASF, where EO is poly (ethylene oxide) and PO is poly (propylene oxide)] was chosen as a structure directing agent. MBGs were synthesized according to the methods we reported before [9,12]. For the synthesis of MBGs with different compositions, the amounts of silicon and calcium precursors [tetraethyl orthosilicate (TEOS) and Ca(NO3)2 Æ 4H2O, respectively] were shown in Table 1, while the amounts of other reagents were the same. In the synthesis, 4.0 g of P123, 0.73 g of triethyl phosphate (TEP), 1.0 g of 0.5 M HCl, and the silicon and calcium precursors were dissolved in 60 g of ethanol and stirred at room temperature for 1 day. The molar ratio (percentage · 100) of SiO2 (S) and CaO (C) were used to denote MBG samples with different compositions and the P2O5 content is kept at 5% in all samples (see Table 1). The resulting sol was introduced into a Petri dish to undergo an evaporation-induced self-assembly (EISA) process. The dried gels were calcined at 973 K for 5 h to remove the template. Calcined MBGs with different compositions were ground and sieved, the fractions with sizes in the Table 1 The amounts of silicon and calcium precursors used for MBGs with different compositions
Ca(NO3)2 Æ 4H2O/g
8.3 7.5 6.7 5.8 5.0
/ 0.47 1.4 2.4 3.3
range of 76–38 lm were selected and conformed in disks (0.1 g) by uniaxial pressure (3 MPa). The incorporation of the drug into MBGs is followed by the common method which is used to adsorb small molecules into mesopores [7,8,15]. The MBG disks were soaked in the saturated acetone solution of TC for 3 days to adsorb the drug. The disks loaded with drug were dried in air and the final product was designated as MBG–TC in text. 2.2. Characterization of samples The samples before and after drug adsorption were characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA) and N2 adsorption–desorption. The weight ratio of TC to MBG was determined from the TGA. The MBGs before and after drug adsorption were evaluated by Fourier-transform infrared (FTIR) analysis to detect the interaction between TC and MBGs. The XRD patterns were obtained with a Bruker D4 powder X-ray diffractometer using Cu Ka radiation (40 kV, 40 mA). The TGA profiles were carried out between 298 and 973 K under air flow using a Mettler Toledo TGA/SDTA851e instrument, the flow rate is 80 mL/min and the heating rate is 5 K/min. N2 adsorption–desorption isotherms were measured with a Tristar3000 analyzer at 77 K. The samples were conformed in disks by an uniaxial pressure of 3 MPa and degassed under vacuum at 453 K for 5 h before measurement. Absorbance FTIR spectra were collected with the use of a Nicolet FTIR 360 (KBr method). 2.3. In vitro drug release The release profile of TC was obtained by soaking MBG–TC in a simulated body fluid (SBF) [16] at 310 K with constant stirring. In spite of the different weight percentage of MBG–TC, the specific ratio of TC in starting MBG–TC to SBF is kept at 0.1 mg/ml. The concentration of TC released into SBF was evaluated by ultraviolet–visible (UV) spectroscopy at 267 nm using a Jasco V-550 spectrophotometer. 3. Results and discussion 3.1. Characterization of MBG and MBG–TC 3.1.1. XRD patterns XRD patterns of MBG 80S15C (S denotes silica, C represents calcium, and the numbers are the molar percentages of compositions in the MBG materials) and MBG 80S15C– TC are shown in Fig. 2. The pattern of MBG 80S15C exhibits three diffraction peaks at 1.21, 2.06, and 2.38, which can be assigned to the 10, 11, and 20 reflections of a 2D hexagonal space group (p6m) [12]. For MBG 80S15C–TC, the intensity of the 10 peak is dramatically decreased, while the 11 and 20 peaks cannot be observed
L. Zhao et al. / Microporous and Mesoporous Materials 109 (2008) 210–215
the pore sizes of both materials are similar (see Table 2). Therefore, the higher / in the latter material loaded with TC should be attributed to the difference in CaO contents. The above results indicate that there is a certain interaction between TC and calcium species and the introduction of CaO in MBG framework may finally influence the TC loading ratio in MBG materials.
Fig. 2. XRD patterns of calcined MBG 80S15C and MBG 80S15C–TC.
in the XRD pattern. The above observation indicates that the drug molecules have been adsorbed into the channels of MBG, similar to the XRD pattern evolution before and after loading ibuprofen in mesoporous silicas [17]. 3.1.2. TGA results and N2 sorption analysis The physicochemical parameters measured by N2 sorption analysis of both MBGs and MBG–TC materials as well as the drug loading percentage in MBG–TC with different compositions are shown in Table 2. Comparing MBG–TC to MBG with the same composition, it can be seen that the surface area, pore volume and pore size are decreased, suggesting that TC has been loaded into the mesopores of MBG materials. The drug loading weight percentage (/) in MBG–TC materials with different compositions show a strong dependence on the composition of MBG. Increasing the CaO content from 0% (MBG 100) to 5% (MBG 90S5C) leads to a dramatic increase in / from 10.5% to 15.5%. Further increasing the CaO content from 5% to 35% (MBG 60S35C) results in a relatively small augment in / from 15.5% to 18.3%. Moreover, it should be noted that the pore volume and surface area of MBG 90S5C are larger than those of MBG 60S35C, and Table 2 Physicochemical properties of MBGs and MBG–TC samples
3.1.3. FTIR The FTIR spectra of TC, MBG 100S and MBG 100S– TC are shown in Fig. 3a. Three peaks located at 1520, 1456 and 1400 cm1 can be found in the spectrum of TC, and these peaks generally can be found in the same wavenumber in the spectrum of MBG 100–TC. In contrast, for MBG 80S15C–TC, the FTIR spectrum shows peaks at 1497, 1448, and 1414 cm1 in the same region, and the peaks are broadened (Fig. 3b). The above observations strongly indicate that the immobilized TC in the mesopores may chemically bond with calcium species in the framework of MBG materials. This interaction is possibly attributed to the chelation of TC and the calcium species in the pore walls [18]. 3.2. In vitro drug release The TC release profiles from five MBG–TC materials in SBF as a function of time are shown in Fig. 4. Generally the release curves can be separated to two parts: an initial fast release followed by a slow release pattern. The fast release is mainly caused by the dissolution of the drug which is physically adsorbed in MBGs, and the slow release may be attributed to the chemically adsorbed drugs. To make a semi-quantitative comparison, we introduce the following equation to predict the release rate of the fast release part of the profiles according to the theoretical analysis by Higuchi [19], which is used to dealing with the release from a planar system with porous matrix. a ¼ kt1=2
where a is the release amount after time t and k is the release constant. When the drug is dispersed in a matrix and the diffusion occurs through solvent-filled pores, the formulation of the constant k is given by
k ¼ f ðD; e; s; C; AÞ
269 215 338 287 229 194 147 128 159 146
0.45 0.35 0.46 0.28 0.31 0.19 0.24 0.15 0.27 0.15
6.1 5.5 5.5 5.3 5.2 5.0 5.2 5.1 4.6 4.5
/ 10.5 / 15.5 / 15.8 / 17.4 / 18.3
where D is the diffusivity of the drug in the solvent, s is the tortuosity factor of the system, e is the porosity of the matrix, A is the total amount of the drug present in the matrix and C is the solubility of the drug in the solvent used. Table 3 shows that the release constant k of each MBG in the first 10 h. We can see that during the fast release, the k of MBG 100S is 20.7, which is much larger than the other materials, the MBG90S5C has a release constant of 4.56, a little larger than that of MBG 80S15C and 70S25C (k is 3.23 and 3.05, respectively). However, it is noted that MBG 60S35C with the largest CaO content presents a
Note: S is BET surface area, V is pore volume and D is BJH pore size of MBGs and MBG–TC materials. / is the TC loading weight percentage in MBG–TC materials.
L. Zhao et al. / Microporous and Mesoporous Materials 109 (2008) 210–215
Fig. 4. The release profiles of tetracycline as a function of time from MBGs with different compositions.
Table 3 The release constant of MBGs materials in the first 10 h, R is the liner regression coefficient and k is the release constant
Fig. 3. The FTIR spectra of: (a) TC, MBG 100S and MBG 100S–TC and (b) TC, MBG 80S15C, MBG 80S15C–TC.
quite abnormal larger k of 5.01 even compared to that of MBG 90S5C.
20.7 4.56 3.23 3.05 5.01
0.976 0.992 0.992 0.992 0.991
The TC release profile of MBG 100S shows a quite different behavior compared to those of other MBGs in the entire time range (0–120 h) under study. For MBG 100S, the time at which half of TC is released is 1.9 h, and the release profile reaches equilibrium at 24 h and the TC released content is higher than 90%. For the other four MBGs, the TC concentration released in SBF reaches equilibrium after 72 h, and the TC released content is 98%, 56%, 25%, 25%, 38% for MBG 100S, 90S5C, 80S15C, 70S25C, 60S35C, respectively. Again, the release profile and the equilibrium released concentration of TC for MBG 60S35C is abnormal compared to other MBGs. The different drug release behavior of MBGs can be explained by their difference in composition. In our studies, all the MBGs possess the same structure, similar pore size, pore volume and surface area, and the release experiment is carried out all in SBF, therefore the parameters of D, e, s and C should be similar for all MBGs, the difference in the release kinetics (k) in the first 10 h should be mainly attributed to A. It is proposed that there are two types of TC molecules adsorbed in the mesopores of MBG (Fig. 5): the physically adsorbed TC (type I) and chemically adsorbed TC (type II) through chelation with calcium species on the pore wall of MBGs. In the initial release period (<10 h) of MBG–TC in SBF, the fast release kinetics may associate predominantly with type I TC. Although MBG 100S–TC without CaO content has the smallest / (Table 2), the majority of the
L. Zhao et al. / Microporous and Mesoporous Materials 109 (2008) 210–215
SBF Ca2+ TC
Ca2+ TC Ca2+ TC —Ca TC —Ca TC —Ca TC
TC Ca —
TC Ca —
—Ca TC
TC Ca —
pore wall
pore wall
TC Ca —
TC —Ca TC
TC Ca — TC Ca —
—Ca TC —Ca TC
TC TC Ca —
Fig. 6. The FTIR spectra of unreacted MBG 80S15C–TC and 80S15C– TC reacted in SBF for 24 h. Fig. 5. Proposed scheme of different types of TC molecules adsorbed in MBG and during the release process: (I) physically adsorbed TC, (II) TC chelated with calcium on the pore wall, and (III) TC chelated with calcium ions in SBF solution.
TC (>72 h) in MBG 60S35C is larger than that in MBG 80S15C and 70S25C. 3.3. In vitro bioactivity of MBGs 80S15C–TC
drug adsorbed in the material is type I TC according to our IR results. Compared MBG 90S5C to MBG 100S, it is proposed that both types I and II TC molecules are present in the mesopores and the fraction of type I TC is dramatically decreased due to the presence of calcium species in the former material. Increasing the content of CaO in MBGs may further decrease the fraction of type I TC and in turn, A, which should represent the initial concentration of type I TC in MBG, decreases as the CaO content increases because the initial ratio of TC/SBF is a constant. As a consequence, the release kinetics of MBG–TC is greatly influenced by their composition (more specifically, the CaO content), similar to the influence of composition upon A we discussed above. Moreover, the change in equilibrium released concentration of TC (>72 h) in different MBG– TC materials can be understood following our proposed mechanism. Increasing the CaO content may increase the fraction of type II TC in MBG–TC materials, which are much more difficult to release compared to type I TC molecules. In the above discussion, the abnormal release behavior of MBG 60S35C is not considered. In fact, during the TC release process in SBF, the calcium ions in solutions may chelate with TC (Fig. 5), this type III TC should be taken into account. The chelation between TC and calcium in solution (type III TC) may compete with the chelation between TC and calcium in the solid framework (type II TC) and finally influence the release behavior. In our previous study, it has been observed that the maximum calcium concentration released by MBG 60S35C is about two times higher than that of other MBGs [13]. Therefore, the higher concentration of calcium ions in solution favors the formation of type III TC and fastens the release kinetics. As a result, the release rate of MBG 60S35C is eventually larger and the equilibrium released concentration of
The IR spectra of MBG 80S15C–TC and MBG 80S15C–TC after soaking in SBF for 24 h are shown in Fig. 6. A new peak at 958 cm1 can be observed, which corresponds to the P–O band [20]. The IR observation suggests that an apatite layer can be formed on the surface of MBG–TC after immersing in SBF for 24 h, in accordance with our previous results [13]. 4. Conclusions In this work, we studied the in vitro drug release behaviors of MBGs with different compositions for the antiinflammatory TC. The results show that the CaO contents of MBGs significantly influence the release kinetic because of the chelation between the drug and the calcium species. The release rate of MBG 100S without CaO in the framework is much faster than the other MBGs. MBG 90S5C, 80S15C, and 70S25C show slow release profiles and the release rate decreases as the CaO content increases. However, in the case of MBG 60S35C, as the CaO content is further increased, the release of the drug in the first 10 h is actually accelerated even compared to MBG 90S5C. Our results clearly depict the composition/drug release behavior in MBG biomaterials. By understanding the composition/drug release and composition/bioactivity correlations of MBGs, it is expected that MBG-drug may be used as bone repair material with build-in anti-inflammation function in bone reconstruction applications. Acknowledgments This work is supported by the NSF of China (20573021), the Ministry of Education of China (20060246010, FANEDD 200423), the State Key Research
L. Zhao et al. / Microporous and Mesoporous Materials 109 (2008) 210–215
Program (2006CB0N0302), Shanghai Science Committee (05SU07098, 05DJ14005), and Shanghai HuaYi Group. References [1] L.L. Hench, R. Splinter, W. Allen, T. Greenlee, J. Biomed. Mater. Res. 2 (1971) 117. [2] L.L. Hench, J.M. Polak, Science 295 (2002) 1014. [3] M. Vallet-Regi, J. Chem. Soc., Dalton Trans. (2001) 97. [4] G. Goller, F.N. Oktar, L.S. Ozyegin, E.S. Kayali, E. Demirkesen, Mater. Lett. 58 (2004) 2599. [5] P. Sepulveda, J.R. Jones, L.L. Hench, J. Biomed. Mater. Res. 59 (2002) 340. [6] M. Vallet-Regi, C.V. Ragel, A.J. Salinas, Eur. J. Inorg. Chem. (2003) 1029. [7] P. Horcajada, A. Ramila, J. Perez-Pariente, M. Vallet-Regi, Micropor. Mesopor. Mater. 68 (2004) 105. [8] A.L. Doadrio, E.M.B. Sousa, J.C. Doadrio, J.P. Pariente, I. Izquierdo-Barba, M. Vallet-Regi, J. Control. Release 97 (2004) 125. [9] X.X. Yan, C.Z. Yu, X.F. Zhou, J.W. Tang, D.Y. Zhao, Angew. Chem., Int. Ed. 43 (2004) 5980.
[10] Q.H. Shi, J.F. Wang, J.P. Zhang, J. Fan, G.D. Stucky, Adv. Mater. 18 (2006) 1038. [11] A. Lopez-Noriega, D. Arcos, I. Izquierdo-Barba, Y. Sakamoto, O. Terasaki, M. Vallet-Regi, Chem. Mater. 18 (2006) 3137. [12] X.X. Yan, H.X. Deng, X.H. Huang, G.Q. Lu, S.Z. Qiao, D.Y. Zhao, C.Z. Yu, J. Non-Cryst. Solids 351 (2005) 3209. [13] X.X. Yan, X.H. Huang, C.Z. Yu, H.X. Deng, Y. Wang, Z.D. Zhang, S.Z. Qiaoc, G.Q. Lu, D.Y. Zhao, Biomaterials 27 (2006) 3396. [14] M. Wikesjo¨, J. Baker, L. Christersson, J. Genco, M. Lyall, S. Hic, M. Diflorio, P. Terranova, J. Periodont. Res. 21 (1986) 322. [15] I. Izquierdo-Barba, A. Martinez, A.L. Doadrio, J. Perez-Pariente, M. Vallet-Regi, Eur. J. Pharm. Sci. 26 (2005) 365. [16] T. Kokubo, H. Kushitani, S. Sakka, T. Kitsugi, T. Yamamuro, J. Biomed. Mater. Res. 24 (1990) 721. [17] F.Y. Qu, G.S. Zhu, H.M. Lin, W.W. Zhang, J.Y. Sun, S.G. Li, S.L. Qiu, J. Solid State. Chem. 179 (2006) 2027. [18] E.C. Newman, C.W. Frank, J. Pharm. Sci. 65 (1976) 1728. [19] T. Higuchi, J. Pharm. Sci. 52 (1963) 1145. [20] M. Vallet-Regi, A.M. Romero, C.V. Ragel, R.Z. LeGeros, J. Biomed. Mater. Res. 44 (1999) 416.
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Captain Hooker, #2
How many years have you played roller derby?
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Had to retire from rugby because it was too hard on my body. Fellow retired rugger recruited me to my organal league. Plus.... Rollerskating!!! Duh!
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HP Z820 doesn't boot up, fans at high speed, no BIOS, no signal in monitor.
Hi everyone,
My workstation specs: HP Z820, Dual Xeon E5-2687W @ 3.1-3.8 GHz, Nvidia quadro K5000, 64GB RAM, 2 x 500 GB HDD.
The workstation is still under warranty.
The issuse happened after upgrading to Windows 10 (from Windows 8.1) and updating the BIOS as recommended by the HP support assisstant.
I was on the process of refreshing the Windows 10 and then the system automatically tried to restart in order to finish the refresh but It never restarted! and then the fans started spinning at full speed. After waiting for 2-3 minutes I had to hold the power button to turn the computer off.
After waiting for about 10 minutes I tried to start the computer but the same happened: Pressed the power button and then after about one minute the fans spinning at high speed, no signal, no BIOS, no sound, no power in keyboard or mouse, blue LED light at rear.
So I left the computer off with no power for 7 hours..... ( The power cable is disconnected).
At 11am: Reconnected the power cable (HDD and DVD ROM are DISCONNECTED) and tried to start however the same happened.
Now I'm on google to find a solution:
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2. Motherboard? No physical damage to capacitors or anything else.
3. Resetting the BIOS/CMOS? (Power cable disconnected) Removed the battery and put it back, held the CMOS button for 5 seconds.
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5. Discharging the power from the system? held the power button with the power cable disconnected for 30 seconds.
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HP Z820 doesn't boot up, fans at high speed, no BIOS, no signal in monitor.
Please HP call support to get the replacement part. Firsto fo all I suspect the power io cable having the thermal sensor. Next supsect is the blind mate cable. Please work work HP agent when you you call HP Support.
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The Nobel Prize in Physics 1954
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UPDATE: Veronica was even more amazing during our wedding weekend! Warm, professional, kind, and easy to work with, she made us and our families feel comfortable and at ease at both our City Hall ceremony and our reception the next day. Not only did she do an expert job wrangling our families, she also was able to recognize when we were starting to fade, suggesting a champgane break with our bridal party that was not only necessary, but also resulted in some of our favorite shots! Our wedding photos are gorgeous, and most importantly, capture the joy we felt throughout the weekend. We feel super grateful to have found her!


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text: The gorgeous Seattle Public Library's Main Branch hosted the awards again this year (In October 2017, forgive me, I'm so late!) and once more it was a sparkly Seattle evening full of literary beauty, some of very best books of the year. I was honored to be nominated again for my second novel, UP TO THIS POINTE. But the best part of the night was cheering for my friend Dan Gemeinhart, whose SOME KIND OF COURAGE won for Middle Grade, and then my dear friend and writing partner M.J. Beaufrand's USELES BAY won the Young Adult honor! We all cavorted with cookies and drinks and we signed books with fellow authors, librarians, book sellers, readers, and family. I love the Seattle Public Library - especially librarian, author, and friend Linda Johns. The PNW literary community could not be more wonderous, and it is my great joy to be part of the family.


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Tesla to offer free unlimited charging for Model S and Model X cars
Tesla has revealed that it will be offering free unlimited supercharging with any purchase of its Model S or Model X vehicles.
Despite being a service that chief executive Elon Musk previously called 'unsustainable', the introduction of free charging for Tesla's top-end models will mean thousands of pounds in terms of savings for owners.
Though little information has been released regarding the details of the offer – and just a tweet via Tesla's official Twitter page to confirm it – it's likely that the move has been made in order to re-energise sales of both the Model S and Model X cars.
The announcement follows on from larger than expected losses by the American manufacturer, which posted losses of $408 million (circa £327m) during the second quarter of 2019, despite record deliveries of its cars.
At the end of July Tesla announced that it delivered 95,365 cars and produced 87,048 cars in the first quarter of the year – an increase compared with 91,000 and 86,000 respective units in the final quarter of 2018.
Tesla's network of electric car charging points is one of the most widespread in the world, with 290 superchargers located in the UK alone. These are backed by more than 550 Tesla destination chargers, which allow owners to top up their batteries at the end of their trip – albeit at a slower rate than the superchargers.


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Effectiveness and our bad intuition towards it
My childhood home is having made some reparations at the moment. Old walls are torn down, new ones are build. It is a long and expensive process, so I told my parents that I would lend a hand. My job was to clean the old bricks from mortar and cement, so that they may be reused. Also, the dust is dangerous for plants and animals, so I had to be carefull to collect the dust in a large container. I quickly reckoned that this would take a long time. I had an entire wall of bricks that need to be broken down, collected, cleaned and stacked.
I started this project by stacking the bricks on pallet, and scraping the old binding material with sandpaper. I had properly done this for nearly three hours, when one of our workmen noticed that I made very little progress. He came back with a screwdriver and two boards, measured the length of the brick and fastened the boards one bricks length from each other, so that I could fix the stones between them. This small insertion took about 2 minutes, by I was amazed at how much my speed improved. When the stones was not sliding away from me, I could clear the rocks a lot quicker. I was even more amazed, that I did not realise that I could make this change myself.
This revelation of making small adjustment with virtually no material or time costs, but with huge upsides seems constantly present in any project where a lot of effort is to be exerted over a long time period. The problem is that our intuitions is often fighting us because we don't feel productive when we evaluate. We like to work without interruptions. Hence, we often misread evaluating our process with taking a break. I think Bill Gates summarised it beautifully when he said: "always chose a lazy person to do a difficult job, because he will find an easy way to do it" .
The problem is that evaluating a process takes mental energy. Something that is incredibly energy intensive. On average the human brain consumes about 25% of the caloric intake during a normal day despite only being 2% of our body weight. Hence, our brain does everything it can to limit cognitive tasks. As a result, the brain has two main modes of operation, often conceptualised in the names given by nobel laureate Daniel Kahnmann, system 1 and system 2. System 1 is our modus operandi, it is automatic, intuitive, quick and unconscious but prone to error. Sytem 2 is deliberate, conscious, cognitively straining and slow but reliable. "2+2?" is a system 1 question. We know intuitively the answer was "4". "7 x 546" is system 2 question, it requires deliberate attention and the answer (which is 3822) is not intuitive.
When we repeat a process a couple of times, it becomes a system 1 task, so we stop thinking about it. That is the moment where we need to be conscious of alternatives. We need to step back and evaluate. Can this be done better?
There is nothing wrong with a strong work ethic, but sometimes it is a hindrance to being productive. We need to reframe breaks as a part of being effective, rather than sluggishness. As Abraham Lincoln famously was quoted: "Give me six hours to chop down a tree, and I will spend the first four sharpening the axe."


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The holidays can produce an amazing amount of garbage and recycling! From party remnants, wrapping paper and packaging from gifts or even just a Christmas tree ready to retire, the excess can be overwhelming. Thankfully the City of Auburn has again partnered with Waste Management and Republic Waste to ensure your holidays don't go sour – like that buttermilk you forgot about.
Christmas & New Years Day Holiday Collection Schedule
Pick up will be ONE day delayed:
- Tuesday collection will be on Wednesday (12/26/18 & 1/2/19)
- Wednesday collection will be on Thursday (12/27/18 & 1/3/19)
- Thursday collection will be on Friday (12/28/18 & 1/4/19).
- Friday collection will be on Saturday (12/29/18 & 1/5/19).
Not sure about recycling wrapping paper? According to the King County Solid Waste Division, "Most wrapping paper can be recycled in your home recycling container. A little tape is fine, but remove the big pieces. Consider saving reusable wrapping paper, along with ribbons and bows. Glittery paper and ribbons you can't use again should go in the garbage." Here is a more extensive guide to ensuring you're recycling properly!
Christmas Tree Recycling Collection Event
January 7 – 11, 2019
Waste Management and Republic Services residents who live within the city limits of Auburn can recycle their Christmas tree and wreath for FREE.
Single-family and mobile home park residents place your tree/wreath by your carts on garbage collection day by 7:00 AM. Do not block collection containers.
Multifamily residents place your tree/wreath by your garbage collection area on Monday, January 7 by 6:00 AM.
- Cut the tree into 4-foot pieces or put into compost cart (if available).
- Tree trunk should be no wider than 4″ in diameter.
- Remove all garland, tinsel, and ornaments.
- No flocked or imitation trees/wreaths or other debris is accepted.
- Limit 1 tree and wreath per household.
Don't throw away your old Christmas Lights!
Auburn Riverside's Orchestra Booster Club is hosting Recycle Event January 12, 2019, from 10am-2pm. The event will be held in the parking lot of Auburn Riverside High School: 503 Oravetz Rd. Auburn, Washington 98092
Bring your unwanted eWaste – Christmas lights, computers*, laptops*, monitors, printers, ink/toner, remotes, DVD/BluRay players, AC adapters, cable/satellite boxes, TVs, MP3 players, anything that plugs in can be recycled at this event-broken & not!
*all hard drive data will be automatically wiped at the UpTekk facility
UpTekk and the Big Brothers and Big Sisters of Puget Sound will also be present with bins available to recycle clothing, household items, and scrap metal.
This event is to help the orchestra attend the spring 2019 WWU Music Festival.
Holiday Styrofoam Collection Events
The City of Auburn is partnering with Safeway Stores to provide FREE Styrofoam block recycling for residents who live within the city limits of Auburn
Hours: 10:00 AM – 5:00 PM
What to bring: Styrofoam Blocks
- Look for the #6 or EPS symbol.
- Clean & dry material ONLY, free of tape and any labels.
- No packing peanuts, cups, food trays, plastic wrap, other plastics or recyclables.
Dates / Locations:
- January 5, 2019 – Safeway Store, 101 Auburn Way S
- January 12, 2019 – Albertson Store, 4010 A ST SE


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Exercise in cute and comfortable stretch tops, shorts and pants. Maternity Breathe stripe strappy shelf tank. We strive to enhance comfort, quality and cuteness of baby essentials with gentle fabrics and detailed designs for your little one.
There are plenty of fly-by-night products around(pretty much all of the ones in local stores) that only offer a very subpar purity. Often times such supplements(like ones sold at WalMart) only contain 20 or less HCA- even when they are marked as higher(this was the conclusion of a recent study).
Such low-grade products(like the ones from GNC usually) are basically scams, replete with fillers and additives and dont do much to give you the true benefits of the natural extract. One of the biggest advantages of GC is its ability to prevent carbs from becoming fatty acids once inside the body- which is a result of the HCAs effects. Remember to take the dosage that is recommended on the bottle and do not deviate from it.
Don't miss out on your opportunity to snag dresses on sale so you can look your best on a budget. Find a pair of affordable heels or a casual pair of sneakers from our selection of sale shoes. From jeans on sale. to clearance jackets, we have everything you need to rock your look at a low price. Overstock uses cookies to ensure you get the best experience on our site. If you continue on our site, you consent to the use of such cookies. Explore Kohl's Clearance section for great deals on items from every department. Discover discounts on clothes, jewelry, shoes, toys and home goods. Kohl's sales provide you with the chance to save big on trendy women's clothing, baby clothes, .


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You can add accrued leave to unlocked pay runs.
To add accrued leave:
- Open the (unlocked) pay run and click on the employee.
- Under Leave Accrued heading, click on the pencil icon to edit.
- Enter the number of Hours.
- Add notes as required.
- Click the pencil icon again, and click the Save.


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Religious Book Club
Open to both men and women, the Religious Book Club meets at 1:00 p.m. on the fourth Monday of the month, from September through May. A different book is read each month and discussed at the meetings. Sometimes these discussions get very lively! If you enjoy reading, you will enjoy being a part of this group.
The Book Club will be discussing the book, Blood Red Murder by Elise M. Stone. This is book 2 of the African Violet Club Mysteries that are loaned to us by Sue Davis.
A new resident to the Rainbow Ranch Retirement Community, Ruby is a friend of resident, Willie O'Mara from many years ago. She is murdered during an African violet repotting demonstration when the residents are crammed closely together. Thinking he is the only one that knew Ruby, Willie becomes the primary suspect. In order to prove his innocence, resident Lilliana comes to the aid of the small-town police chief.
This month's meeting will be held on Tuesday (a change of date), April 23 at 1:00 pm. Please join us. If you would like to read the book before the meeting, send an email to email@example.com or just join us for the discussion and treats.
September 23, 2019
8:00 am and 10:30 am
All-Family Sunday School 9:15 am
September thru May
About All Saints
Come to the About Us section to meet , and find out what we're all about!
All Saints Constitution Revised 8.7.18
Tuesday Night Bible Study 7:30 pm Meets in the Main Conference Room Led by Steve Reid (On Hiatus until Fall)
Wednesday Afternooon Bible Study 1:30 pm Meets in the Main Conference Room Led by Pastor Janet Wold (On Hiatus until Fall)
Sunday Morning Bible Study 9:15 am Meets in the Small Conference Room (#209) Led by Steve Jones (On Hiatus until after Rally Day)
Coming Events
September 8 - Sunday School Rally Day
September 8 - Annual Church Picnic
Scripture Texts
July 14 - 5th Sunday after Pentecost
Deuteronomy 30:9-14
Psalm 25:1-10
Colossians 1:1-14
Luke 10:25-37
July 21 - 6th Sunday after Pentecost
Genesis 18:1-10a
Psalm 15
Colossians 1:15-28
Luke 10:38-42
July 28 - 7th Sunday after Pentecost
Genesis 18:20-32
Psalm 138
Colossians 2:6-15
Luke 11:1-13
The following group meets weekly at All Saints.
What is the ELCA?
Find out about the Evangelical Lutheran Church in America and the history of this wonderful organization on our What is ELCA page.
Members Login


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Yanagisawa A 9935 Alto Solid SILVER
Yanagisawa A 9935 Alto Solid SILVER
This 9935 alto is in great shape and truly impressed me. I get to try a lot of saxophones and this one justifies its cost and materials as it is incredibly rich tonally and expertly designed. For a very serious player it might be just the thing.
This particular one was just serviced by my expert technician who works for some of the biggest names in jazz saxophone. It did not need much but when he tweaks the horn speaks. The one single issue is a cosmetic one near the straphook as shown and all it does is save you money. Aside from that one area it is in the 98%+ range cosmetically with no damage, dents, resolders. Obviously a horn of this quality will be treated very well by its owner and this one is no exception other than the poor choice of strap hook. New these horns sell in excess of $7000 and used floor models comparable to this one sell for $5500. My price is substantially lower.
I've added many photos with and without flash so you can really see the horns condition well.


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Whether you know him as a lawyer, winemaker or friend and leader in the community, Dale Rollings is returning to the area as an author for a book signing of The Trunk.
Copies of The Trunk will be available on the evening of the book signing, but for those who want to read ahead to be question-ready for our special guest, copies will be available in limited quantity to reserve beginning June 19th and purchase beginning August 1st. Plus, ask about our book club and quantity discounts.
Also joining us will be local Defiance wineries—Defiance Ridge and Sugar Creek!
We are very excited about this unique opportunity to welcome a friend and talented author, loved and respected by many, for this fun evening. We look forward to seeing you there for an intimate evening full of good music, wine, food and discussion as we welcome Dale to Robin's Nest on the Katy Trail.
* Additional parking can be found at the Katy Trail head commuter lot and behind Katy Bike Rental.


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Tv Stand With Electric Fireplace
Dec 8th
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Good evening,
I was hoping someone could help please?
I'm charged £9.99 a month for my Sky Cinema Month Pass which is fine as I believe my 1 year £55 subscription I purchased automatically changed to a monthly pass.
However, the money is being taken from a credit card that isn't linked to my account. I can also see I have the option to take a Sky Cinema Month Pass even though I already have it.
How can I get my account updated and the card used to pay for this pass changed to the one on the account?
Thanks very much,


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Applying The Risk Management Framework Nist 800 37a
To get started, first identify the appropriate certification program for your skill set. We currently offer 12 different certifications in Civil Engineering Technology and Electrical and Mechanical Systems Engineering Technology.... Incorporating the NIST Cybersecurity Framework into the HITRUST CSF and establishing a certification mechanism as part of the HITRUST CSF Assurance program gives organizations an effective and efficient approach for reporting their cybersecurity posture leveraging the NIST …
FedRAMP FISMA Compliance Audit NIST Certification
The National Institute of Standards and Technology (NIST) is a physical sciences laboratory, and a non-regulatory agency of the United States Department of Commerce. Its mission is to promote innovation and industrial competitiveness. NIST's activities are organized into laboratory programs that include nanoscale science and technology, engineering,... Certification is used for verifying that personnel have adequate credentials to practice certain disciplines, as well as for verifying that products meet certain requirements. NVLAP is a system for accrediting laboratories found competent to perform specific tests …
[SOLVED] FISMA Certification....anyone? IT Security
I need to use NIST SP 800-22 approved software / hardware to generate RSA key pair. Where I can find a list of certified software / hardware RNGs compliant to NIST SP 800-22? And how is the SP 80... Stack Exchange Network. Stack Exchange network consists of 174 Q&A communities including Stack Overflow, the largest, most trusted online community for developers to learn, share their knowledge how to fix a stiff gas pedal Most Trusted Certification Design . The design of a certification exam can impact the quality and integrity of a certification. GIAC exam content and question design are developed through a rigorous process led by GIAC's on-staff psychometrician and reviewed by experts in each technical area.
Where I can find a list of certified software / hardware
Earning a security credential can help you open the door to a great job. But you need to know which certification is the right one for you. 1 of 10 As the market for information security talent how to get a health and safety certificate For those of you who are new to the NIST CSF; NIST stands for the National Institute of Standards and Technology and CSF stands for Cybersecurity Framework. People who use the NIST CSF often refer to it simply as the "Framework".
How long can it take?
FedRAMP FISMA Compliance Audit NIST Certification
- What is NIST Compliance? Digital Guardian
- Get Certified! NIST Traceable Temperature Probes Now
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How To Get Nist Certification
NIST 800-171 Compliance actually means DFARS Cybersecurity requirements must be met. The NIST 800-171 requirements have always vexed small manufacturers due to the specific wordiness, so the NIST (National Institute of Standards and Technology) has been trying to make this easier to understand
- Reach out to Best Practice Certification at www.bestpracticecertification.com.au and click the live chat function and someone here manning the live chat facility at Best Practice can answer your question about how much it costs to get ISO 9001 certification.
- The one with NIST certification letter is 2x as expensive. I'm guessing it's the same caliper it has just been tested and verified that it is accurate? Is this worth …
- The Certified Calibration Technician tests, calibrates, maintains, and repairs electrical, mechanical, electromechanical, analytical, and electronic measuring, recording and indicating instruments and equipment for conformance to established standards.
- For those of you who are new to the NIST CSF; NIST stands for the National Institute of Standards and Technology and CSF stands for Cybersecurity Framework. People who use the NIST CSF often refer to it simply as the "Framework".


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Women's Cancer
Gynecological health is an important issue for women.
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Ochsner providers read inspiring letters from their patients.
Allison is an inspiration to her caregivers at Ochsner, who surprised her and her family with a trip to Super Bowl...
January is Cervical Health Awareness Month to help raise awareness about the importance of cervical health.
We can reduce our risk of cancer or cancer recurrence by making healthy choices in our diet and by maintaining a...
Hooters of Louisiana recently raised over $50K in support of the Ochsner Cancer Institute. These funds will be used to research new and innovative breast cancer treatments. This donation comes as part of...
Learn more about gynecological cancer in women:


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Family-Friendly Events
Pacific Beach Bars
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Pacific Beach Blog
Baltimore tickets - Buy online
Posted by ThePacificBeach.com on Wednesday, April 6, 2011
See list of Baltimore attractions below to see more details before buying.
American Visionary Art Museum
Babe Ruth Birthplace and Museum
Maryland Science Center
Spirit Cruises - Baltimore
Sports Legends Museum at Camden Yards
SuperShuttle Baltimore
Medieval Times Baltimore / Washington DC
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The Minimalist Magnolia
Reusable Ring Sizer
Not sure what ring size to choose? We got you! We offer these reusable ring sizers so that you can be more confident about your next ring purchase!
Instructions: Simply slide the simple end into the buckle end to form a ring shape. Slip it over the finger you'd like to size and gently tighten until you find your perfect fit! Once you have found your size, just make sure that you are still able to comfortably slide the sizer over your knuckle as well!
In an effort to keep these inexpensive and accessible for everyone, we have a (2) quantity max per customer for these ring sizers. If you need more for a special occasion, please message us at firstname.lastname@example.com.
Our normal processing time is 1-3 business days. This may vary around large sales, holidays, etc. Please check here for our current and up to date processing times.
- Our free, standard shipping is through USPS First Class mail (domestic only), which usually takes about 2-6 business days to arrive once shipped.
- International orders ship through USPS International First Class mail.
- Shipping upgrades are available at checkout if you need it quicker! Please note that these upgrades will only expedite the shipping time. The current processing time will remain the same.
We happily accept returns for a full refund (minus shipping charges) as long as we are contacted with the intent to return within 7 days of the delivery date and the order is shipped back within 14 days of the delivery date. Return shipping is the responsibility of the buyer. Please note that personalized and custom pieces cannot be returned or exchanged.
You are welcome to exchange your piece for any reason, as long as you contact us within 7 days of the delivery date and return the item within 14 days of the delivery date. Return shipping is the responsibility of the buyer. Processing time for exchanges can take 1-2 weeks once received back in the studio. Please note that personalized and custom pieces cannot be returned or exchanged