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I'm going
by, 06-08-2010 at 01:08 PM (444 Views)
I cant be bothered to post this on a forum
but I believe this is the best thing for me to do right now. Those who have me on msn can still talk to me and i will keep contact with others.
I believe I need to get off of here for a while, just leave this site for a bit. I ts doing me no good. im not in the right frame of mind anymore. ive done some serious damage to myself and the only way i will get to my UGW is doing it alone.
i cant be on here anymore
I'll be back soon
I hope you all do well


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Monday, May 27, 2019
Can I work for Lionbridge and iSoftStone at the same time?
Quick Cash May 27, 2019 work from home , work online No comments :
I've been offered a position with iSoftStone as an ad evaluator, and I'm a rater for Lionbridge at the moment. I've been reading over the terms of employment for Lionbridge and don't see anything about this, but I thought I would check in here just in case. They're different positions, aren't they, so is it alright?
Submitted May 27, 2019 at 10:27PM by BoratisHot http://bit.ly/2EC1ECZ
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subset: commoncrawl


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23.01.2014 by Humberto Cervera
The Road to GDC
So exciting! In case you didn´t know Chaos Industries will have a tabletop booth at GDC Play (Booth 407, come say hi!) and we are incredibly nervous about this.
I have to say, excited as we are, something that really bummed me down was that buying a booth at GDC does not give you conference privileges, you have to pay $900 more bucks to get into the conference when you have already paid $3,000 bucks to be there, come on guys ! We are Indies, show us some love.
That said, I´m just really happy that we will be there. We´ll be taking the Beta of Agent Awesome for you guys to test it out and we are going to be handing out some Agent Awesome related goodies.
Of course, we´ll have a T-Shirt with a badass design by our go to graphic designer, Alvaro. But other than the T-Shirt, what else should we give out?
We had the brilliant idea of handing out Alcohol Themed goodie bags, you know Agent A. is drunk throughout the game so we might as well hand out some drunk related items to our fans.
So in the Agent Awesome goodie bag you´ll be able to find:
- Tshirt
- 100 ml Bottle of Tequila (We are still working with the guys at Moscone to make this happen)
- Tequila Glass
- Beer Glass
- Flask
So when the time comes for you to play Agent Awesome you´ll probably be as hammered as Agent A.
But well guys the point of this post is to throw out this question out in the open, we are nervous, do you guys have any advice for a GDC first timer?
Humberto Cervera
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text: Almost There! Just fill out a little bit of information so we can get started on your website… Name* First Last Email Address* Phone Number*I am interested in...*Creating a new websiteRedesigning an existing websiteIs your existing site built on Wordpress?*YesNoI don't knowWe work exclusively with Wordpress.If you are interested in switching to Wordpress for your existing site, please check a box below and continue filling out this form.Otherwise, check out our friends at Brandastic or BOS Media.I want to switch to WordpressI don't care what platform as long as it looks goodI'll check out BOS Media or Brandastic. Thanks anywaysWebsite*Please enter the URL of your existing website. What would you like done for your existing site?Better layoutDifferent color schemeAdd functionalityImprove performanceMake mobile-friendlySomething elseWhat type of site would this be?*Online StorePromotional SitePrivate Practice WebsiteBlogSomething ElsePlease describe the nature of the site.*Questions? Anything else you'd like to add?


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Operating under the auspices of the United Nationsits purpose is to investigate and combat paranormal and extraterrestrial threats to the Earth. Originally referred to as the United Dating in dark youtube Intelligence Taskforceexecutive producer Russell T Davies claimed in that the UN were no longer happy to be associated with the fictional organisation and the UN's full name could now no longer be used. He credited both scriptwriter and script editor Derrick Sherwin and producer Peter Bryant as having come up with the idea beforehand, claiming that they were testing the concept in The Invasion before it had become central to the show in the Doctor Who serial Spearhead from Space Dicks also said that the idea of exiling the Doctor was done because making every serial take place on Earth was cheaper to produce than if every serial had to have a new alien planet built, and that UNIT was an idea Sherwin had come up with to answer the question of what to do with the Doctor after he was exiled to Earth. In another interview in Doctor Who MagazineSherwin recalled that after submitting his scripts for The Invasion to Bryant, which included UNIT, Sherwin, who was also working freelance as a script editor, was told by Bryant to introduce his UNIT idea earlier, as it could "take some of the weight off [the] shoulders" of actor Patrick Troughtonwho played the Doctor.
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Date lodged: 10 February 2017
To ask the Scottish Government what plans it has to ensure that specialist healthcare advice is available for people with Huntington's disease in (a) Moray, (b) the Scottish Borders, (c) Dumfries and Galloway and (d) other areas of Scotland where it considers there is a lack of this advice.
Answered by: Aileen Campbell 7 March 2017
NHS Boards are responsible for planning and delivering healthcare services, including specialist services, to meet the assessed needs of their resident populations, taking into account strategic frameworks and guidance, within the allocations provided.
Additionally, Scottish Huntington's Association were awarded £120,000 in Scottish Government funding to develop a National Care Framework for people with Huntington's Disease. The framework aims to help ensure families affected by the condition are given the best possible care, information and support - regardless of where they live in Scotland. This work is still under development and we look forward to the publication of the framework, and next phase of this work, later this year.


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Chen, Lin, Karbasi, Amin, Crawford, Forrest W.
Most real-world networks are too large to be measured or studied directly and there is substantial interest in estimating global network properties from smaller sub-samples. One of the most important global properties is the number of vertices/nodes in the network. Estimating the number of vertices in a large network is a major challenge in computer science, epidemiology, demography, and intelligence analysis. In this paper we consider a population random graph G = (V;E) from the stochastic block model (SBM) with K communities/blocks. A sample is obtained by randomly choosing a subset W and letting G(W) be the induced subgraph in G of the vertices in W. In addition to G(W), we observe the total degree of each sampled vertex and its block membership. Given this partial information, we propose an efficient PopULation Size Estimation algorithm, called PULSE, that accurately estimates the size of the whole population as well as the size of each community. To support our theoretical analysis, we perform an exhaustive set of experiments to study the effects of sample size, K, and SBM model parameters on the accuracy of the estimates. The experimental results also demonstrate that PULSE significantly outperforms a widely-used method called the network scale-up estimator in a wide variety of scenarios.
While they are very useful to diagnose typical cases, it is difficult for them to diagnose complicated cases. Therefore various approaches, such as deeper knowledge representation, case-based reasoning, are proposed in order to overcome this problem. However, they axe not sufficient to solve this problem completely. One reason that they are not so sutticient is that they are lacking one important track of diagnosis that medical experts do when they meet complicated cases. In this paper, we introduce combination of reasoning, planning and learning methods in order to solve this difficulty.
Peot, Mark Alan, Shachter, Ross D.
The process of diagnosis involves learning about the state of a system from various observations of symptoms or findings about the system. Sophisticated Bayesian (and other) algorithms have been developed to revise and maintain beliefs about the system as observations are made. Nonetheless, diagnostic models have tended to ignore some common sense reasoning exploited by human diagnosticians; In particular, one can learn from which observations have not been made, in the spirit of conversational implicature. There are two concepts that we describe to extract information from the observations not made. First, some symptoms, if present, are more likely to be reported before others. Second, most human diagnosticians and expert systems are economical in their data-gathering, searching first where they are more likely to find symptoms present. Thus, there is a desirable bias toward reporting symptoms that are present. We develop a simple model for these concepts that can significantly improve diagnostic inference.
Shenoy, Pradeep, Yu, Angela J., Rao, Rajesh P.
Intelligent agents are often faced with the need to choose actions with uncertain consequences, and to modify those actions according to ongoing sensory processing and changing task demands. The requisite ability to dynamically modify or cancel planned actions is known as inhibitory control in psychology. We formalize inhibitory control as a rational decision-making problem, and apply to it to the classical stop-signal task. Using Bayesian inference and stochastic control tools, we show that the optimal policy systematically depends on various parameters of the problem, such as the relative costs of different action choices, the noise level of sensory inputs, and the dynamics of changing environmental demands. Our normative model accounts for a range of behavioral data in humans and animals in the stop-signal task, suggesting that the brain implements statistically optimal, dynamically adaptive, and reward-sensitive decision-making in the context of inhibitory control problems.
We propose an abductive diagnosis theory that integrates probabilistic, causal and taxonomic knowledge. Probabilistic knowledge allows us to select the most likely explanation; causal knowledge allows us to make reasonable independence assumptions; taxonomic knowledge allows causation to be modeled at different levels of detail, and allows observations be described in different levels of precision. Unlike most other approaches where a causal explanation is a hypothesis that one or more causative events occurred, we define an explanation of a set of observations to be an occurrence of a chain of causation events. These causation events constitute a scenario where all the observations are true. We show that the probabilities of the scenarios can be computed from the conditional probabilities of the causation events. Abductive reasoning is inherently complex even if only modest expressive power is allowed. However, our abduction algorithm is exponential only in the number of observations to be explained, and is polynomial in the size of the knowledge base. This contrasts with many other abduction procedures that are exponential in the size of the knowledge base.


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Five ways to cut how much you use at home and out and about
We've all become used to being able to pick up a bottle of something refreshing and a handily packed snack to enjoy on the go. While at home, everything from the food in our kitchens to the toiletries in our bathrooms comes wrapped in plastic. The trouble is, when we're done with it, plastic travels – it's even turning up on the most remote paradise islands. To help make sure we're not sharing our beach breaks with yesterday's rubbish, we can all take steps to cut down the amount of plastic we use. Here are a few ways to get started:
One of the easiest ways to start reducing your plastic usage is by thinking about your drinks. If you can't begin the day without your take-out coffee, pick up a reusable mug – many cafes offer a discount for bringing your own. Plus, with countless styles and designs to choose from, they look so much better, too.
The same goes for reusable water bottles – which have now become something of a style statement. Find your favourite (we love Built NY's brushed steel designs) and stay hydrated on the go. If you're more of a mineral or sparkling water or soda drinker, look for options in glass bottles rather than plastic.
Try to always have a foldaway tote bag or two with you for spur-of-the-moment buys – whether it's a quick grocery shop or a can't-pass-up shoe sale.
When it comes to picking up groceries, choose loose fruits and vegetables over pre-wrapped ones. Try to avoid using plastic produce bags – either by bringing your own smaller, reusable bags or just keeping them loose.
We live in an age of convenience, with countless prepared foods that simply go from the freezer to the oven to our plates. As well as often not being as good for us health-wise as meals prepared from scratch, they're usually heavy on unrecyclable plastic packaging.
So, to reduce the plastic content of your food shop even more, rekindle your creativity in the kitchen by focusing on buying fresh ingredients.
- Bread – grab it freshly baked, then store in your own cloth bag
- Meat and fish – bring your own plastic containers to the meat and fish counter
- Vegetables – swap freezer bags for loose, seasonal produce. Buy sauce bases such as tinned chopped tomatoes rather than pre-made options.
- Coffee and tea – for a barista-standard coffee of your own, invest in an at-home coffee grinder and buy your beans loose, avoiding wasteful coffee pod machines. Teabags are often sealed with plastic, so buy loose leaf instead and use a metal infuser.
From washing hair to cleaning teeth and doing make up, much of our daily routine finds us using plastic-packed products. Thankfully, reducing how much you use needn't mean going completely 'au naturel'.
Have fun exploring all sorts of solid shampoo, conditioner and skin-moisturising balms available from brands such as Lush. Swap disposable plastic toothbrushes for wood and natural fibre ones, or use an electric toothbrush with replaceable heads that use less plastic. Consider using solid, powder-based toothpastes or go all the way and brush your teeth with water and baking soda – which you can bulk buy and store in reusable containers.
Finding plastic-free make up can be a little more difficult. If you often use a lot of products, try to streamline your day-to-day looks. Look out for brands that use more easily recyclable packaging such as metal and cardboard. US-based Fat & the Moon has time-tested options such as kohl that doubles as eyeliner and mascara, as well as solid lip paints. Then, instead of disposable makeup wipes, look for reusable cotton pads.
Cleaning products are another big culprit for plastic use. If you use a dishwasher, Ecoleaf sells plastic-free tablets. If you hand-wash, swap synthetic sponges and scrubbers for natural and washable ones. There's plenty of inspiration on the internet for those who want to start making their own cleaning products, too. Most are based on tried-and-trusted products such as baking soda, or vinegar and water infused with essential oils.


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PepsiCo Egypt is planning to invest $ 515 million in the local market over the next four years, including $ 16 million to develop its beverage production lines, its chairman and CEO Mohamed Shelbaya.
PepsiCo also plans to upgrade its fleet and distribution centers and will expand the domestic cultivation of its agricultural raw materials.
The 2018-2021 investment plan depends on three pillars namely investment in technology, the agricultural sector, social responsibility programs and the human element, as the company considers Egypt among the region's top markets, the CEO added,
He also noted that between 2014 and 2017, PepsiCo's investments in the Egyptian market totalled $660 million.
PepsiCo has "invested in Egypt every year regardless of the difficulties" since the US-based company first brought its business to Egypt 70 years ago, Shelbaya said.
"We want to be ready to jump on opportunities once conditions improve, rather than wait to invest and struggle to catch these windows," Shelbaya added,
The food and beverage sector is expected to grow at a 16% this year, he noted.


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Oasmia publishes its annual report and adjusts accounts due to write-downs - auditors do not recommend former board to be granted discharge from liability
Oasmia Pharmaceutical AB's annual report for the fiscal year 2018/2019 is now available on the company's website www.oasmia.com. Compared to the year-end report, which was published on June 28, the financial statements for the fiscal year have been adjusted as a result of non-cash flow write-downs of SEK 30.9 million. The result for the year and equity are therefore negatively affected by the same amount.
The company's auditors also recommend that members of the former board not to be discharged from liability.
The write-downs mainly relate to balanced development costs of SEK 25.0 million in the project KB9520, which was acquired from Karo Bio in 2016. In addition, write-downs refer to inventories of SEK 5.5 million and other items of SEK 0.4 million.
Oasmia's auditors PwC do not recommend that the members of the former Board of Directors, Julian Aleksov, Lars Bergkvist, Bo Cederstrand, Alexander Kotsinas and Per Langö, to be granted discharge from liability. PWC however recommends that former CEO Mikael Asp is to be granted discharge from liability, as well as the members of the current Board of Directors Jörgen Olsson, Gunilla Öhman, Sven Rohmann and Peter Zonabend.
This information is inside information that Oasmia Pharmaceutical AB (publ) is obliged to make public pursuant to the EU Market Abuse Regulation and information that Oasmia Pharmaceutical AB (publ) is obliged to make public pursuant to the Securities Market Act. The information was submitted for publication, through the agency of the contact person set out above, at 15.00 CET on September 5, 2019.
For more information:
Investor Relations Oasmia
E-mail: email@example.com
About Oasmia Pharmaceutical AB
Oasmia Pharmaceutical AB develops, manufactures, markets and sells new generations of drugs in the field of human and veterinary oncology. The company's product development aims to create and manufacture novel nanoparticle formulations and drug-delivery systems based on well-established cytostatics which, in comparison with current alternatives, show improved properties, reduced side-effects, and expanded applications. The company's product development is based on its proprietary in-house research and company patents. Oasmia is listed on Frankfurt Stock Exchange (OMAX.GR, ISIN SE0000722365) and NASDAQ Stockholm (OASM.ST).
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AIR Worldwide Estimates Insured Losses for Typhoon Faxai Will be Between USD 3 Billion and USD 7 Billion15.9.2019 22:40:00 CEST | Press release
Boston, Sept. 15, 2019 (GLOBE NEWSWIRE) -- Catastrophe risk modeling firm AIR Worldwide estimates that industry insured losses from Typhoon Faxai, which made landfall in Japan on September 9, will be between JPY 340 billion (USD 3 billion) and JPY 740 billion (USD 7 billion). AIR Worldwide is a Verisk (Nasdaq:VRSK) business. According to AIR, Typhoon Faxai made landfall in Yokosuka, a southern suburb of Tokyo, on the main island of Honshu at around 3:00 a.m. local time Monday, September 9, with 1-minute sustained wind speeds of 170km/h (105 mph). Faxai crossed Tokyo Bay to strike Tokyo City with winds still equivalent to a strong Category 2 hurricane. Faxai brought damaging winds across southeastern Honshu, along with storm surge and heavy precipitation to coastal regions. Impacts were reported across Chiba, Kanagawa, and Shizuoka prefectures. Storm surge was highest along the eastern shores of Tokyo Bay: JMA recorded a storm surge of more than 1 meter in Mera, Chiba Prefecture. The ci
Valberedningens förslag till styrelse och revisor för Oasmia Pharmaceutical AB inför årsstämman 201915.9.2019 21:00:00 CEST | Pressemelding
Oasmias valberedning har informerat bolaget om sitt förslag avseende styrelse och revisor inför årsstämman den 26 september 2019. Valberedningen föreslår Hege Hellström och Anders Härfstrand till nya styrelseledamöter. Därutöver föreslås omval av de nuvarande styrelseledamöterna Jörgen Olsson, Peter Zonabend, Gunilla Öhman och Sven Rohmann. Jörgen Olsson föreslås bli omvald som styrelsens ordförande. Hege Hellström har sedan 2013 arbetat på bioteknikbolaget Sobi som chef för EMENAR (Europa, Mellanöstern, Nordafrika och Ryssland). Dessförinnan har hon varit globalt ansvarig för affärsområdet Cardiovascular inom Sanofi, VP Renal Europa och Head of Regional Liaisons på Sanofi samt VP Renal and Endocrine Europe och General Manager Benelux på Genzyme. Innan Genzyme var hon 13 år på Baxter. Hege Hellström är 54 år och har utbildning i Bio-engineering från Ullevaal School of Bioengineering, Oslo, Norge samt en utbildning i marknadsföring och finansiering vid BI, Norwegian Business School. And
The Nomination Committee's proposal regarding Board of Directors and auditor of Oasmia Pharmaceutical AB for AGM 201915.9.2019 21:00:00 CEST | Press release
Oasmia's Nomination Committee has informed the company of its proposal regarding Board of Directors and auditor ahead of the Annual General Meeting September 26, 2019. The Nomination Committee proposes Hege Hellström and Anders Härfstrand as new board members. In addition, the nomination committee proposes re-election of the current Board members Jörgen Olsson, Peter Zonabend, Gunilla Öhman and Sven Rohmann. Jörgen Olsson is proposed to be re-elected as Chairman of the Board. Hege Hellström has worked at the biotechnology company Sobi since 2013 and was president for EMENAR (Europe, Middle East, North Africa and Russia). Prior to that, she was globally responsible for the Cardiovascular business area within Sanofi, VP Renal Europe and Head of Regional Liaisons, Sanofi, VP Renal and Endocrine Europe, Genzyme, General Manager Benelux Genzyme. Before Genzyme, she was 13 years at Baxter. Hege Hellström is 54 years old and has a degree in Bioengineering from Ullevaal School of Bioengineerin
SFL - Change of name to SFL Corporation Ltd. approved13.9.2019 22:55:00 CEST | Press release
SFL Corporation Ltd. (the "Company") today announced that its 2019 Annual General Meeting resolved to change the name of the Company from "Ship Finance International Limited" to "SFL Corporation Ltd.". The Company's common shares will continue to trade under the ticker "SFL" on the New York Stock Exchange. ISIN and instrument ID for the Company's listed securities remain unchanged. September 13, 2019 The Board of Directors SFL Corporation Ltd. Hamilton, Bermuda Investor and Analyst Contacts: Aksel Olesen, Chief Financial Officer, SFL Management AS +47 23 11 40 36 André Reppen, Senior Vice President, SFL Management AS +47 23 11 40 55 Media Contact: Ole B. Hjertaker, Chief Executive Officer, SFL Management AS +47 23 11 40 11 About SFL SFL has a unique track record in the maritime industry, being consistently profitable and paying dividends every quarter since 2004. The Company's fleet of more than 90 vessels is split between tankers, bulkers, container vessels and offshore assets, and SF
SFL - 2019 Annual General Meeting13.9.2019 22:10:00 CEST | Press release
SFL Corporation Ltd. (the "Company") advises that the 2019 Annual General Meeting of the Shareholders of the Company was held on September 13, 2019 at 10:30 a.m. at the Hamilton Princess and Beach Club, 76 Pitts Bay Road, Hamilton HM CX, Bermuda. The audited consolidated financial statements for the Company for the year ended December 31, 2018 were presented to the Meeting. In addition, the following resolutions were passed: 1. To set the maximum number of Directors to be not more than eight. 2. To resolve that vacancies in the number of Directors be designated as casual vacancies and that the Board of Directors be authorised to fill such vacancies as and when it deems fit. 3. To re-elect Harald Thorstein as a Director of the Company. 4. To re-elect Bert M. Bekker as a Director of the Company. 5. To re-elect Gary Vogel as a Director of the Company. 6. To re-elect Keesjan Cordia as a Director of the Company. 7. To re-elect James O'Shaughnessy as a Director of the Company. 8. To approve
FRO – 2019 Annual General Meeting13.9.2019 19:27:00 CEST | Press release
Frontline Ltd. (the "Company") advises that the 2019 Annual General Meeting of the Shareholders of the Company was held on September 13, 2019 at 10:00 a.m. at the Hamilton Princess and Beach Club, 76 Pitts Bay Road, Hamilton HM CX, Bermuda. The audited consolidated financial statements for the Company for the year ended December 31, 2018 were presented to the Meeting. In addition, the following resolutions were passed: To set the maximum number of Directors to be not more than eight. To resolve that vacancies in the number of Directors be designated as casual vacancies and that the Board of Directors be authorised to fill such vacancies as and when it deems fit. To re-elect John Fredriksen as a Director of the Company. To re-elect James O'Shaughnessy as a Director of the Company. To re-elect Ulrika Laurin as a Director of the Company. To re-elect Ola Lorentzon as a Director of the Company. To re-appoint PricewaterhouseCoopers AS of Oslo, Norway as auditors and to authorise the Director


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Domtar pursuing new pulp markets
Chris Marchand
Latest posts by Chris Marchand (see all)
- For Pete's Sake – 2018 Come Together Concert a tribute to late local musician - January 9, 2019
- DREAM project marks progress - April 25, 2018
- Northern Lights impressive - April 25, 2018
There are some things you just can't do on a computer.
That's an important thing to remember when you're a pulp producer looking to diversify demand for your product to new markets like toilet paper, paper towels and other non-fine paper products.
Domtar's Ontario public affairs manager Bonnie Skene delivered a business update to the company's public advisory group, Aug. 18. — highlighting the challenges facing local operations within the international forest product corporation and a competitive global market.
Delivered the day after operations were suspended indefinitely at the Domtar's Ear Falls sawmill, Skene reiterated the company's reasoning behind the closure, citing a collapse in demand in the U.S. housing market exacerbated by high Canadian/U.S. currency exchange rates and high cost structure (transportation, electricity, fibre costs)
Skene says labour negotiations played no role in the indefinite shutdown and holds hope that improving market conditions and efforts to streamline costs could lead to the resumption of operations in Ear Falls.
On the pulp side of things, Skene says the company is walking a fine line in relation to a black liquor subsidy in the U.S. While the controversial alternative fuel incentive program, set to expire Dec. 31, is damaging to the industry in Canada, Skene says Domtar's U.S. operations have qualified for a massive windfall of up to $137 million in tax credits.
In an effort to level the playing field in Canada, the federal government has emerged with its own environmental incentive program aimed at better positioning the industry for the future.
In Dryden, cost structure remains such a challenge that overseas pulp producers are getting their product to North American mills in the midwest and eastern seaboard for less.
Skene says cost reduction is key — finding closer customers to reduce transportation costs and achieving proportionate reductions in fixed costs to reflect the scope of local operations.


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HomeEducation & MeetingsKidney Week
November 02, 2017 | 04:54 PM - 05:06 PM
Click an icon below to load this item into your calendar. Please note that times are exported as Coordinated Universal Time (UTC). Time zone help.
The study of animal models has identified a plethora of genes and pathways driving the repetitive and reciprocal interactions between the Ureteric Bud (UB) and the Metanephric Mesenchyme (MM) that give rise to the collecting system and the nephron pool. However, these expression patterns and how they drive differentiation have not been systematically characterized in the human kidney. We have used single-cell transcriptomics to study individual cell dynamics and characterize the expression profile of the human kidney.
Fetal kidneys (105 to 115 days of gestation) were dissociated to single cells and processed for DropSeq workflow as described by the McCarroll lab. Individual cells were identified by barcodes, and transcripts were tagged with Unique Molecular Identifiers. Paired-end RNASeq was performed on a HiSeq2500 platform. Bioinformatics analysis employed the Picard tools developed by the Broad Institute and unsupervised clustering algorithms were executed with the R package toolkit "Seurat". RNA profiles were mapped into trajectories derived using a nonparametric ridge estimation statistical framework. Gene expression was confirmed by immunofluorescence on fetal kidneys.
Single cell transcriptome analyses of 3,865 cells (fig.A) enabled the distinction of UB-4 and MM-1 progenitors as well as their intermediate and differentiated lineages including the mature collecting ducts-18, the renal vesicle and comma- and s-shaped bodies-2, immature-9 and mature podocytes-13, proximal tubules-6, Henle's loop and distal tubules-8, as well as mesangium-5 and cortical-5 and medullary interstitium-10. Importantly, known as well as novel markers for these cell types were revealed in the analysis.
We have generated an accurate map of gene expression and lineage relationships (fig.B) in the human fetal kidney. These results confirm the expression of genes identified by studying animal models. New gene-expression patterns have also been identified that may help understand human renal development.
© American Society of Nephrology


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Feature FilmReleased Hindi
Mission KashmirContribute
Mission Kashmir is a movie directed by Vidhu Vinod Chopra featuring Sanjay Dutt, Hrithik Roshan.
Cast & Crew
Sanjay Dutt
SSP Inayat Khan
Hrithik Roshan
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Preity Zinta
Sufiya Parvez
Sonali Kulkarni
Neelima Khan
Puru Raajkumar
Malik Ul Khan
Jackie Shroff
Hilal Kohistani
- Budget
- INR 20 Crore (est.)
- Revenue
- INR 43.34 Crore
- Colour
- Colour
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- 0~0
- Aspect Ratio
- 2.35:1
Article Hindi Tamil
The six defining roles of Jackie Shroff – Birthday special
The man who started off as a 'Hero' has also enjoyed playing the bad guy on some occasions.


text: The LiveWorks app for broadcasting VR over the air and using OTT (over the top) platforms will be showcased at the CES show in Las Vegas. The app was created by VR Video and WheresMyMedia, the entities that were awarded a $15,000 grant to develop the prototype by the National Association of Broadcaster's PILOT Challenge. The application uses the new ATSC 3.0 broadcasting standard, which was approved by the FCC in November. ATSC 3.0 and the LiveWorks app will bring immersive content to consumers with next generation TV receivers. — MULTICHANNNEL


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Please be advised that Racing NSW Stewards have permitted James McDonald to be declared as the rider of both No. 1 Antonio Padre and No. 12 Zouriana, which have accepted in Race 1 at Friday's Canterbury Park race meeting.
Trainer Chris Waller has informed Stewards that only one of the horses will be starting in the race.


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Jul 25, 2019
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Since 1979, OneSource has been a leading staffing agency in our markets, matching job seekers to positions that match their ability, experience, and lifestyle. Whether you're looking for part-time or full-time; temporary, temp-to-hire, or direct placement; OneSource has a rewarding opportunity for you. OneSource employees enjoy a weekly paycheck, flexible work schedules, the option of direct deposit, access to a choice of two medical benefit plans after 60 days, access to many leading companies across our markets, job search help such as resume help and interview coaching, and so much more!
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1st Shift Machine Operator will be placing an unfinished spring vertically into a hole on a metal surface so that the ends are grinded flat about 3 quarters. Lifting can be up to 25 lbs. Reliable people with good basic math skills. The machines are making springs and other parts for medical machinery. Person must have good math skills. They will be reading up to 3 decimal points on a caliper.
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It's do-or-die time on drug pricing when Congress returns to Washington in a few weeks.
That's how stakeholders are viewing the whole messy effort to take major action to lower the high prices of prescription medicines in the United States — a top-polling worry among voters that President Trump has repeatedly promised to tackle.
If lawmakers don't find a bipartisan way forward this fall, prospects for anything substantial happening will fade as the 2020 election ramps up and Democrats become even less willing to play ball.
"I think, honestly, if Congress doesn't act on drug pricing by January … then it becomes very, very difficult because we'll be in full election mode then," David Mitchell, founder of the activist group Patients for Affordable Drugs Now, told me.
Trump has made clear — extremely clear — that he wants to deliver something he could term a "win" on prescription drugs by ramping up pressure on pharmaceutical companies and ultimately lowering prices. He has two main routes: either through legislative action, which would have to come from a deal struck between the administration and the Democratic-led House, or through executive branch regulations.
But the whole project, opposed fiercely by the pharmaceutical industry, is convoluted, and its outcome is still unclear.
As we've previously detailed in The Health 202, the clearest legislative route is through a bipartisan but nonetheless controversial bill capping, for the first time ever, how much drugmakers could increase the prices of medications in the Medicare program.
Senate Finance Committee Chairman Chuck Grassley (R-Iowa), under heavy pressure from the administration to advance the measure, is furiously lobbying his fellow Republicans to support the legislation, after just six voted to pass it in committee last month. Toward that end, he and Sen. Ron Wyden (Ore.), the committee's ranking Democrat, are eyeing some modifications including getting at the rebates collected by pharmacy benefit managers and ensuring more of the bill's savings go directly to seniors.
Consumer advocates are working hard, too. Today, Patients for Affordable Drugs will launch a seven-figure ad campaign in six states targeted at Republican senators who Mitchell told me he considers persuadable. The ads, which urges support for the Grassley measure, will run in Iowa, Louisiana, Texas, Ohio, Montana and Indiana.
The version of the ad running in Iowa:
Then there are the administration's actions. Health and Human Services Secretary Alex Azar has suffered two hefty setbacks, recently tabling an aggressive proposal banning pharmacy rebates and seeing a court block a separate regulation requiring the display of drug prices in television ads.
But he and Trump have at least two other irons in the fire: a proposal to tie some Medicare drug prices to an international index and a potential executive order to allow some drug imports from Canada.
And then there's the move Republicans would dislike most of all: Allowing Medicare to negotiate directly with drugmakers for lower prices. House Democrats are expected to roll out their own proposal along those lines next month, but House Speaker Nancy Pelosi's (D-Calif.) office has been engaged with the administration in discussions about a potential deal.
Grassley has warned his fellow Republicans that they might have to swallow such actions if they don't support his bill.
"Look at what's down the road," Grassley said after the Finance Committee's 19-to-9 vote advancing the bill. "It seems to me the Grassley-Wyden approach is a very mild approach to what could come out. There ought to be a realization on the part of Republicans about this and there ought to be a realization on the part of pharmaceutical companies where they would be."
If there weren't already enough factors in play, consider this: a challenge to the Affordable Care Act that could end up dismantling the whole law. The U.S. Court of Appeals for the 5th Circuit is expected to rule on the high-profile lawsuit this fall. If it strikes the health-care law, that could spell doom for any bipartisan effort on health care this year, period, given the administration's refusal to defend the law in court.
But for now, patient advocates are remaining hopeful.
"I'm not trying to be Pollyanna, but everyone wants to do something on drug pricing," Mitchell said. "In both parties there is strong energy to do something. The question is how much."
To readers: The Health 202 will publish on Tuesdays, Wednesdays and Thursdays this week and next and will take a break the week of Aug. 26 before returning full-time in September.
AHH: One of the largest-ever surveys on views about abortion found that although support for the procedure remains steady, there are deepening partisan divides on the issue.
A 54 percent majority of Americans say abortion should be legal in all or most cases, while 40 percent say it should be illegal, according to the Public Religion Research Institute survey released yesterday, our Washington Post colleagues Ariana Eunjung Cha and Scott Clement report. But the survey found the gap between Democrats and Republicans on support for the procedure increased from 28 to 36 points in the past four years.
In no state are there more than a quarter of residents who reported supporting a total ban on abortions. "States with the largest proportion of residents who say abortion should be illegal in all cases are Louisiana at 23 percent; Mississippi at 22 percent; and Arkansas, Nebraska, Tennessee at 21 percent," our colleagues write. "Many of these same states have moved to restrict abortion in recent months through legislation, administrative measures, and in courts."
OOF: Two counties in California are suing the Trump administration to try to stop it from implementing a new rule making it more difficult for legal immigrants to obtain a green card if they use public benefits such as food stamps or housing assistance.
"Officials with Santa Clara County and San Francisco said in a lawsuit filed Tuesday that the 'public charge' rule 'coerces' legal immigrants into dropping out of public health, food and housing programs, which could lead local governments to carry the burden of millions of dollars in public assistance," our colleague Maria Sacchetti reports. "The jurisdictions asked a judge with the U.S. District Court for the Northern District of California to block the policy immediately."
The Health 202 wrote yesterday about new public charge rule, under which officials could consider the age, health, assets, financial and family status, education level and resources when considering whether to approve a green card.
"Lawyers for Santa Clara County and San Francisco said the Trump administration is trying to scare immigrants away from desperately needed public assistance, and they warn that the broader community could suffer from higher local assistance costs or the spread of diseases due to a lack of health care," Maria writes. "Untreated tuberculosis or Zika could lead to public outbreaks, they say."
— California Attorney General Xavier Becerra also announced last night he's preparing to sue the Trump admnistration on behalf of the entire state.
"We think it's un-American" Becerra told CNN's Anderson Cooper last night. "It's unlawful and it would destroy good portions of our economy if we were to allow a rule like this to take effect."
"This policy won't stand...I can say that to you as not just the attorney general from the state of California, I say it to you as an American...as a son of immigrants."— Anderson Cooper 360° (@AC360) August 14, 2019
Xavier Becerra vows to a fight a Trump WH rule that could limit legal immigration over public benefits use. pic.twitter.com/OQ6HGQBbTJ
OUCH: An influential national panel of health experts is now recommending that doctors screen all adult patients for illicit drug use. It's the first time the U.S. Preventive Services Task Force, an independent panel appointed by the Department of Health and Human Services, is making such a recommendation, in hopes that such screening by health-care providers can slow the opioid epidemic.
The draft guidelines said "that health providers should attempt to determine whether their patients 18 or older are using illicit drugs, including nonmedical use of prescription drugs. But the panel said it did not have enough information to decide whether all adolescents should be screened," our Post colleague Lenny Bernstein reports.
The panel cited a 2017 national survey that found 11.5 percent of Americans ages 18 and older were using illegal drugs. That year, 70,237 people died of drug overdoses across the country, Lenny writes. The task force "suggested several questionnaires, administered by health care providers or taken by patients on their own, that it said were effective in picking up illicit drug use."
— The House Judiciary Committee is expected to return a week early from its August recess to consider a set of gun-control measures, but our Post colleagues Rachael Bade and Paul Kane report there's disagreement among Democrats privately over what measures to advance.
While Democrats agree on expaning background checks and have also united around ideas including so-called "red flag" laws and the restriction of high-capacity magazines, there's disagreement about whether to approve legislation to reinstate an assault weapons ban that expired 15 years ago. Rep. David N. Cicilline (D-R.I.), a member of Speaker Nancy Pelosi's (D-Calif.) leadership team, wants to vote on an assault weapons ban; Pelosi's team "worries that the chamber won't have the votes to pass that bill, however, and hopes to focus instead on supporting gun legislation that could garner bipartisan backing."
In the meantime, Democrats have publicly targeted Senate Majority Leader Mitch McConnell (R-Ky.) for inaction on gun legislation, including for refusing to take up a background checks bill the House has already passed.
— In the wake of recent mass shootings, Democrats are calling on the Senate to return from recess to consider the House background checks bill and urging Pelosi to call the House back into session to pass other aggressive gun measures. And just like that, the issue of the August recess has become a political cudgel amid a the gun-control debate, Paul writes.
And Trump told reporters yesterday he believes the Senate Republican leader is poised to act on at least one gun measure. "I am convinced that Mitch wants to do something," Trump said. "He wants to do background checks."
— Over the weekend, volunteers working with the advocacy arm of the Alzheimer's Association pushed Democratic candidates at the Iowa State Fair about their plan to fight the disease.
The volunteers, with the Alzheimer's Impact Movement, want the issue to be central ahead of the 2020 campaign, Stat's Nicholas Florko reports, and volunteers have been swarming campaign events across the country.
"But a candidate's stance on any disease — whether it be cancer, Alzheimer's or heart disease — isn't going to win him or her the election, according to Bob Blendon, a Harvard University professor and an expert on health care politics," Nicholas writes. "While voters care about disease — and Alzheimer's consistently ranks among the most important diseases to voters — the issue alone is unlikely to swing voters, he said."
But for advocacy groups, a key strategy is to get candidates to talk about and advance the issue, a way to increase the odds that politicians will take action on the issue in the future. To that end, some Democratic presidential candidates have released plans to address Alzheimer's, including Sen. Amy Klobuchar (D-Minn.), who released a plan that includes expanding what services are covered by Medicare, and former Texas congressman Beto O'Rourke, who has called for doubling funding for federal research on Alzheimer's.
— And here are a few more good reads:
- The House Financial Services Committee holds a hearing in Los Angeles on the homelessness crisis.
Why the Iowa State Fair is key for presidential candidates:


text:
Keep your head high and looking up. Learn from the past and dream about the future. There's nothing like a beautiful sunset to end a great day.Read More
I believe in the process. I believe in four seasons. I believe that winter's tough, but spring's coming. I believe that there's a growing season. And I think that you realize that in life, you grow. You get better.Read More
It doesn't matter how beautiful your theory is, it doesn't matter how smart you are. If it doesn't work with your experiment, it's wrong.Read More
Clouds come floating into my life, no longer to carry rain or usher storm, but to add color to my sunset sky.
- Rabindranath TagoreRead More
What makes "street" such a wonderful outlet of artistic expression for me is this readily availability. I just have to put on my walking shoes and go out with eyes wide open and full of curiosity.Read More


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- Color: Multi-color
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Product Details
Pink Folding Wedge Incline Memory Foam Pillow Bamboo Cover for Reading Acid
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text:
The No-Till Market Garden, Kristyn Leach of Namu Farm
Super honored to be joined by Kristyn Leach of Namu Farm to talk about her work with Kitzawa Seed Co and more. [No]Dig the podcast? Step up to our 1k challenge!
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A DISTRAUGHT farming family is counting the cost of the latest horrific attack by dogs on their prize-winning sheep.
Three premier rams sustained life threatening injuries and the additional 17-strong flock was left traumatised by the attack at a field at Waterside, Greenfield.
Claire Crowther, daughter of the Saddleworth farming dynasty, took to social media in a bid to trace the owners of the dogs.
She said: "Somebody must have seen something as it's obviously been a prolonged attack to cause so much damage to some of the rams.
"Three of the rams required immediate veterinary treatment and if anybody saw the dogs or owners in the field please send the descriptions."
Her father Christopher said: "The rams are tough but they are very vulnerable when dogs get among them.
"I reckon there must have been more than one dog and they must have been very strong.
"The injuries to the rams were really vicious and sustained. It's amazing they survived."
Angela Bloomfield, Mr Crowther's partner, added: "The injured rams had panicked and left the field. We found them covered in blood in a resident's garden. It was a dreadful mess.
"This kind of attack on vulnerable animals is totally devastating. The dog owners should be accountable."
Last April, Angela was at the scene of a mindless dog attack when, in just one day, 12 lambs were killed at Fairbanks Farm, Diggle.
A few weeks ago sheep farmer Darren Hough hosted a mini summit at his Saddleworth farm with local MP Debbie Abrahams, police and National Farmers Union representatives to examine how to protect farm livestock and safeguard property.
But days later Mr Hough found a dead ewe with horrific wounds from a dog worrying incident in one if his fields.
The National Sheep Association (NSA) has targeted agricultural events and shows to promote responsible dog ownership to reduce incidents of sheep worrying.
Their spokesperson said: "We need to continue to build positive relationships with the dog-owning public to ensure improved behaviour of the minority of dog walkers that allow their animals to run free around livestock, often with devastating results.
"We share the frustration of our members about the number of completely avoidable attacks on sheep but browbeating the public and portraying negative messages about shooting dogs is not an effective message.
"We want to share a positive message about dog owners enjoying the beautiful landscapes in Britain, which are created by the hard work of sheep farmers, and to do so responsibly and consider the impact an attack can have on farmers business and livelihood."


text: I HATED ABSOLUTELY EVERYTHING ABOUT THIS BOOK. EVERYTHING. LOUD NOISES! This was one of those novels that both Audible and Amazon have been recommending to me for over a year. I was so sick of seeing the stupid cover in my You Might Like… feeds that I felt obligated to just read it and be done with it. I honestly and truly assumed that I would enjoy it. I was so very wrong. So very, very wrong. Continue reading "Where'd You Go, Bernadette? by Maria Semple"


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Created attachment 189988 [details]
just tried to create new partition on a removable pendrive (da0) on a FreeBSD system where '/' is on ZFS (Boot Environment).
When I tried to 'Commit' the changes I got an error that a mountpoint of '/' must exist ... and sade is not able to detect one as its on ZFS.
Details in the attachement.
Plase modify /usr/sbin/sade so it will NOT check for the existing '/' mount, as its quite usable as 'graphical' partition manager in base.


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The increase in marrow adipogenesis associated with osteoporosis and age-related osteopenia is well known clinically. However, we are only now beginning to understand the mechanisms that control the differentiation of mesenchymal stem cells to either osteoblasts or adipocytes. Recent work with gene silencing and overexpression has provided insight into critical pathways that determine the fate of these multipotential cells. In vitro and in vivo studies strongly support an inverse relationship between the commitment of bone marrow-derived mesenchymal stem cells or stromal cells to the adipoctye and osteoblast lineage pathways.
Bone formation is regulated by Runx2/Cbfa 1, a member of the runt homology domain transcription factor family while fat formation depends on the peroxisome proliferator-activated receptor gamma (PPARγ). In vitro studies using bone marrow-derived MSCs find that induction of adipocyte differentiation inhibits osteoblastic bone formation. Likewise, agents inducing osteoblast dfferentiation inhibit adipogenesis.
Parathyroid Hormone (PTH) regulates bone formation and resorption. Indeed, intermittent PTH is the most potent bone anabolic agent known and works, in part, by reactivation of quiescent bone surfaces and reducing osteoblast apoptosis. Significantly, continuous PTH infusion increases bone resorption and bone loss. We investigated the possibility that intermittent and continuous PTH treatment also differentially regulates osteogenic and adipocytic lineage commitment of bone marrow stromal progenitor / mesenchymal stem cells (MSC). Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells. This response may explain, in part, the mechanism that causes the overall bone anabolic action of intermittent PTH.
05 - 08 Mar 2007
Society for Endocrinology
British Endocrine Societies


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Abby's Dad
- Jan 23, 2009
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I understand batting/slapping from the left side puts you closer to first base - although I question this as a true advantage since the left sided batter needs to pivot to run while the right sided batter is already facing first base. To me if a hitter can slap hit/bunt from the right side she's putting the defense in an even more difficult situation since they won't know if she's hitting/slapping or bunting.
Your thoughts are appreciated.
Your thoughts are appreciated.


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January Chapter Meeting - Genius Forum
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Sun, April 20, 2014 7:13 AM
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Carollyn Rock
A special thank you to Malia Nolan for submitting the following commentary on the January Chapter Meeting.
My ASTD Genius Forum Experience,
By Malia Nolan, Sagatica Consultant
If you've never attended a Genius Forum, the collaborative process can be surprising
and unexpected. Its not every day that professionals from multiple backgrounds
come together to share their knowledge and ideas for bettering organizations.
Genius Forums create space for powerful breakthroughs, and I am grateful to have
been a participant.
The event, held at the Torrey Hills Hilton, was titled, "Why Culture Eats Strategy for
Breakfast: an Experiential Approach to Driving Leadership Change". It was hosted
by the San Diego ASTD and local Leadership Consulting firm, Sagatica.
The event began with Sagatica CEO Eric Kaufmann welcoming us and giving an
insightful presentation on the importance of engagement, which he defined as "the
extent to which employees feel passionate about their jobs, are committed to the
organization, and put discretionary effort into their work." Much of the presentation
focused on ways to lead others with greater awareness, and therefore increase our
The presentation was rich with Eric's characteristic insightfulness and self-effacing
humor. A key to the presentation was the use of what he calls the "Four Virtues" of
Focus, Courage, Grit, and Faith, that ask us what we are creating, avoiding,
sustaining, and yielding (or letting go of) at any given moment. He shared that we
can use these principles, or "virtues", at any time to create more engaged
workplaces simply by becoming mindful of how we are choosing to lead and interact
with others. By this point, I was definitely inspired!
After Eric's presentation, Sagatica's COO and ASTD Board Member, Gregg
Fasbinder, stepped in, and led the 50 or so participants to a large circle with lots of
colored paper and pens piled up in the center. Many of the attendees looked
curiously at the pile, and I think we all wondered what was in store for us! He
introduced himself and then gently asked us to close our eyes for a moment and
become fully present. He shared that we were participating in this exercise as a way
to share all of our collective wisdom on how to create cultures of engagement in the
workplace. I haven't attended many business functions that focused on workplace
culture and mindfulness, and found myself feeling excited and grateful to be among
such a group of people.
From there, Gregg gave a brief overview of the structure of a Genius Forum, and
explained how the group would be utilizing open-space technology (a facilitation
method developed over 30 years ago and used around the world) to develop
strategies for creating cultures of engagement.
We learned that the governing rule of Genius Forums is "the Law of Two Feet",
which urges participants to join group discussions for as long, or as little, as they'd
like. "If you lose passion and excitement about the topic, move on," he explained. He
then added, with a friendly laugh, "How often do you get the chance to walk out in
the middle of a meeting?" Here, walking out was not only allowed, it was
He continued to outline the four principles of the Genius Forum, explaining,
. Whoever comes is the right people. This means that neither the number of
participants nor the actual participants are as important as the quality of
their interactions and conversations. For good conversation, you only need
one other person who shares your passion.
. Whatever happens is the only thing that could have. Real learning and
progress take place when we move beyond our original agendas - if
everything happened just the way we wanted it, life would be dull, and
learning would be limited. It is in moments of surprise that we grow.
. Whenever it starts is the right time. Creativity and spirit are critical for open
space meetings, and neither pay much attention to the clock. They appear in
their own time, which by definition means the right time can be at any
. Whenever it's over, it's over. And conversely, when it's not over, it's not over.
The time and space allocated is only as effective as the conversation and
meaningful interaction that's happening. Passion and content are the drivers
for Genius Forums, not the artificial boundaries of the clock.
After discussing the parameters, Gregg asked everyone to imagine one idea they had
to create a culture of engagement, and then walk into the center of the circle and
write it on a piece of colored paper. What was amazing to me was that most people
didn't just have one idea – they had many! And they were great!
Ideas ranged from allowing 24 hour periods where employees could work on one
project without distraction, to creating greater communication with upper-level
management. They also included ideas like introducing stress-management
activities, happy hour, and movie nights. It was interesting to see how much people
knew and wanted to share once given the chance. All in all, we generated about 100
great ideas to build cultures of engagement in our workplaces, and challenged our
expectations about what was actually possible.
After this initial activity we broke into three small groups, called "Open
Marketplaces" where we tackled specific challenges to creating cultures of
engagement, such how to increase creativity. We were all asked to contribute our
ideas and suggestions, and then take it a step further and reflect on our own
experience or knowledge that would be supportive in making these ideas happen.
This kept the focus on positive action, rather then just generating ideas. We focused
on what action we could take to make our work more engaged now. We were also
given the freedom to utilize "The Law of 2 Feet" at any time, which kept discussions
far more inspired, as we knew we could move on at any time.
The experience of the genius forum was very eye-opening for me. I had never
attended a business event that placed such emphasis on creative improvement and
collective wisdom. I learned that we often know much more then we think we do,
and all have valuable insights to contribute to make in our workplaces (and our
lives) more engaged, productive, and happy. Several weeks later, I've already taken
creative action in my own life and am reaping the benefits.
Read more about the results from the our event.
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