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Active-pixel CMOS sensors improve their image
Active-column sensor imager contains random-access decoders, correlated double-sampling circuits, and unity gain amplifiers (located top to bottom, respectively, at top right of image). Pixel area is at lower right and timing generator is at upper left
After initial false starts, CMOS (complementary metal oxide semiconductor) imagers are now finding their way into desktop video systems, digital still cameras, and other products. The lure of low power, self-clocking, random access, nondestructive reading, antiblooming, and radiation tolerance is proving irresistible. Additionally, all of the control functions that are normally part of the camera system or frame grabber can be implemented on chip at low cost. The only remaining issue is how to implement the new capabilities in a product that is better and less expensive than products based on traditional technologies.
Initially CMOS imagers soured many potential users when image quality didn`t meet the hype. The single biggest obstacle to implementation of early CMOS imagers was the quality of video or the signal-to-noise ratio of the imager. With each succeeding generation, however, the signal-to-noise ratio has improved. An understanding of the pixel types may help engineers select a "camera on a chip" or "Chip Camera" technology for specific applications.
First-generation CMOS imagers - Traditional imagers were separated into three categories: the photodiode, the photogate or charge-injection device (CID), and the ubiquitous charge-coupled device (CCD). All three types were in production by the early 1970s using proprietary metal oxide semiconductor (MOS) processes to optimize the wafer yield and electro-optical characteristics. All three pixel types are considered passive in that the pixel does not have the signal buffered at the pixel site. From the 1970s through the early 1990s, relatively little was accomplished in the fabrication of CMOS area arrays. Each manufacturer of imagers had a MOS process with unique characteristics that allowed the manufacturer to survive profitably. As CMOS processes became the standard the world over and digital designs with a million transistors became commonplace, it became possible to shift area-array designs to a standard CMOS process. Hence, the first-generation CMOS imagers were developed.
Passive pixel CMOS arrays were the first generation, as all three passive pixel types were ported to CMOS. Now all three passive pixel arrays could take advantage of the CMOS process and add any and all necessary timing or video-processing functions as needed. Also, major improvements in signal-to-noise ratio for photodiodes and CIDs could be made by adding an amplifier per column or per row. In the case of a CID the total charge collected in the pixel is divided by the column capacitance, when sensed (see Fig. 1). Because capacitors in parallel add, the total column capacitance is equal to the capacitance of a pixel multiplied by the number of pixels in the column. For example, if the maximum signal at the pixel collection photogate is 2 V for a 5-V process, the signal, when transferred to the sense photogate, is divided by the number of pixels in the column. If there are 500 pixels in the column the signal level is divided by 500 or is only 0.004 V when measured. The reduced signal at the end of the column is further degraded by the video bus capacitance.
In older MOS processes it was only feasible to place one amplifier per array. In a MOS process, only one type of field-effect transistor (FET) is available to design amplifiers. Therefore, the resulting MOS amplifier was much larger and consumed more power than a comparable CMOS amplifier. With smaller, lower-power CMOS amplifiers, it was now possible to place an amplifier per column to isolate one column from the rest and limit the signal degradation. Also, the amplifier per column could be an amplifier with gain to rebuild the weak signal. With an amplifier per column the whole row could be buffered and have signal conditioning all at once. In effect the video bandwidth of the video-processing chain was now at line rate, not element rate. In other words the amplifier bandwidth was kilohertz, not megahertz, further improving the signal-to-noise ratio.
The amplifier per column (or row) does help to minimize the effects of sensing the photodiode or photogate pixel signal from the periphery. CCDs don`t suffer from the same problems as photogates or photodiodes because the signal collected at the pixel site is shifted to the amplifier located at the periphery. The CCD signal remains intact until it is shifted to the amplifier, with little or no degradation. CCDs, having the lowest noise floor, have dominated the market. However, they suffer from high power consumption, fixed reading format, and exact timing requirements to operate properly. Ideally, a sensor would have the flexibility of a photodiode or photogate and provide the high-quality video of a CCD. To that end, a small buffer added to a photogate or photodiode would isolate the pixel signal from the rest of the array.
Second-generation CMOS imagers - Sensors that implement a buffer per pixel are known as active-pixel sensors and represent the second generation of CMOS imagers. Adding a buffer per pixel is as simple as adding a source follower, made from one FET, and a method of biasing the pixel site, usually by adding another FET (see Fig. 2). At first one may assume that passive pixels should have a higher fill factor than active pixels. But when it comes to interline-transfer CCDs, that isn`t the case.
In interline transfer CCDs, which dominate consumer electronics, the CCD register occupies about half of the pixel size. The other half is used to collect photon-generated charge. Depending on the process used and pixel size, active-pixel sensors can have equal or better fill factor than interline CCDs. Active-pixel sensors have all the flexibility of CIDs or photodiodes and benefit from adding all the necessary timing and video processing with signal-to-noise ratios normally associated with CCDs. However, active pixels that use source followers per pixel suffer from a relatively high level of fixed pattern noise (FPN) that is objectionable to the average viewer, if not corrected in either hardware or software.
The high level of FPN associated with active-pixel sensors that use source followers for pixel buffers is due to wafer process variations that cause slight differences in the transistor thresholds and gain characteristics. Fixed pattern noise is an offset from the video average; it makes a monitor look like a dirty window screen has been superimposed on it. There are up to three possible sources of FPN. The first is the source-follower load FET. Because there is typically only one source-follower load FET per column of pixels, the FPN is column-related. The second is the source-follower in the pixel site. The source-follower pixel FET FPN is random throughout the pixel array. The third source is dependent on the type of correlated double-sampling (CDS) circuit employed. If the CDS circuit employed uses more source-followers to buffer the video per column, then it may add more FPN on a column-by-column basis.
The same process variations that cause threshold variations per FET also cause each source-follower FET to have slightly different transconductances. The transconductance variation causes each pixel to have different source-follower gains. Each pixel has its own source follower per pixel, and source followers have less than a gain of one and typically Av = 0.86. If the gain variations per imager range an optimistic ?2% with a maximum signal level of 2 V at the pixel site, the resulting net gain change is 70 mV. This gain variation may not be part of a vendor`s stated signal-to-noise ratio. The symptom of each pixel having different gains is the dirty-window screen effect described above, which gets worse with high levels of video.
The source-follower gain variations per pixel are added to the normal gain variations that occur within each pixel, whether it is active or passive. Slight process variations that cause the above gain and threshold variations also cause slight differences, depending on how efficient each pixel is in converting photons into electrons across an imaging array.
The threshold variations that cause offsets in the video background can be almost completely eliminated with a CDS circuit, except for the third source described above. CDS circuits eliminates the pixel offsets by subtracting the background reference bias from the actual background reference of a particular pixel. The gain variation per pixel, however, cannot be easily eliminated. To properly correct for gain variations, each pixel gain would have to be stored in memory and all pixels corrected to the same gain. Due to the intensive processing of pixel-by-pixel gain correction, this solution may only be acceptable for low-bandwidth applications like still digital cameras. Another less-intensive method would be to filter (smooth) the video to minimize objectionable pixels from the viewer.
Although active-pixel sensors may have high signal-to-noise ratios, they suffer from gain variations that create objectionable (nonuniform) video. Ideally, the pixel structure would have minimal FPN and would not have gain variations from pixel to pixel. A method to eliminate the gain variations would include a full unity gain amplifier (UGA) per pixel. A UGA maintains a gain of one, by feedback from the output to the input (see Fig. 3).
One UGA per pixel would eliminate the gain variations from pixel to pixel, but the six FETs also needed would consume most of the pixel area. However, a unity gain amplifier per pixel could be implemented if all the common FETs were located at each column and only the input signal differential FET remained at the pixel site. In effect each pixel of a selected row, via a dual-gate FET, completed a UGA per column; hence, this pixel-and-amplifier combination is called an active-column sensor (see photo on p. 111). At each column a CDS circuit eliminates video background offsets.
With the knowledge of how different CMOS pixels operate, engineers can optimize the advantageous aspects of CMOS active pixels for their applications. As always, no single imager or pixel type will serve all needs, and it is up to the designer to make the best selection for a particular purpose. o

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Intervention to Change Attributions that are Negative (ICAN): a New Approach to Reducing Anger and Aggression after Brain Injury"Anger is common after TBI. Past studies show that anger can sometimes be the result of the way a person ...
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Tabou Foilbräda AIRRIDE är en helt nydesignad modell som i senaste PWA leverarat toppresultat om och om igen.
Den raka outlinen samt en bottenform med kraftiga cut-outs gör att man står perfekt när man flyger och kan sätta kraft i lovartskanten för att få maximal vinkel så foilen får bästa höjd och fart.
Tez, you are an experienced freeride foiler. Could you tell us what freeride foiling is about and what you enjoy the most about it?
Tez: For most people, freeride windfoiling will be about making use of light wind (sub-18 knots) and flying back and forth. Gybes will then be the move of choice I think. This is a good thing and definitely the main area industry bods should be focusing on rather than pouring all energy into high performance ends of the spectrum - foilstyle and racing (although these niches do need due attention as well).
There are two main reasons I like windfoiling. Flying back and forth in 12 knots of wind, effortlessly, with the sun beating down and nobody else on the water is pretty much picture postcard perfect. This was my scene most days this summer with the UK experiencing Mediterranean like conditions. It was like this for about 7 weeks!
The other reason is I can be on much smaller sails than most others. If it's 25-30 knots then great. But for everything below that threshold being able to use your small sails when all other riders are still on big rigs is just bliss. Why restle with anything bigger when you don't need to...?
What level do you need to be able to start freeride windfoiling?
Tez: I don't think there's a level that we can categorically say is when you should start foiling. In one of your previous articles about a light wind spot in Brazil, Marcello was explaining how he takes beginner windsurfers and transitions them to foiling as soon as they've cracked the sport's fundamentals. And why not? After all, learning to foil is no harder than learning to plane using a harness and footstraps.
In fact, due to there being no real necessity to use footstraps and harnesses foiling for progressing riders could end up being easier. For most sailors looking at foiling they'll already be planing comfortably. Some maybe going round corners whilst others will be aiming to crack that elusive carve gybe.
WIDTH 91cm LENGTH 226cm
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Back to Journals » OncoTargets and Therapy » Volume 12
SUVmax and metabolic tumor volume: surrogate image biomarkers of KRAS mutation status in colorectal cancer
Authors Lv Y, Wang X, Liang L, Wang L, Lu J
Received 1 December 2018
Accepted for publication 5 February 2019
Published 21 March 2019 Volume 2019:12 Pages 2115—2121
DOI https://doi.org/10.2147/OTT.S196725
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 3
Editor who approved publication: Dr William Cho
Ying Lv,1,* Xin Wang,2,3,* Lerong Liang,4 Lei Wang,5 Jie Lu6
1Department of Gastroenterology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, People's Republic of China; 2Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, People's Republic of China; 3Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan 250117, Shandong, People's Republic of China; 4Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, People's Republic of China; 5Department of Gastrointestinal Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, People's Republic of China; 6Department of Neurosurgery, Shandong Province Qianfoshan Hospital of Shandong University, Jinan 250014, Shandong, People's Republic of China
*These authors contributed equally to this work
Purpose: The objective of this study was to explore the association between KRAS mutation status and PET/CT metabolic parameters in colorectal cancer (CRC) patients.
Materials and methods: One hundred and sixty-four CRC patients were enrolled in this study and received PET/CT examination before operation, then KRAS mutation status was analyzed through pathologically confirmed CRC samples. The association between tumor clinical characteristics and PET/CT metabolic parameters, including maximum standardized uptake value (SUVmax), SUVmean, and metabolic tumor volume (MTV), and KRAS mutation status was analyzed using chi-squared tests, Mann–Whitney U tests, and logistic regression analysis.
Results: The KRAS mutation type patients exhibited high MTV and high SUVmax using a threshold of 17.8 cm3 and 8.7 respectively and the predictive accuracy was 0.772 and 0.603 respectively. High MTV (P=0.001; 95% CI: 1.119–1.296) and high SUVmax (P=0.048; 95% CI: 0.564–0.985) were independent predictors for KRAS mutation status.
Conclusion: MTV and SUVmax were associated with KRAS mutation type in CRC patients. PET/CT metabolic parameters can be used for supplementing KRAS mutation status prediction in CRC patients.
Keywords: colorectal cancer, 18F-FDG PET/CT, SUVmax, SUVmean, MTV, KRAS mutation
Colorectal cancer (CRC) has high incidence and is the third most common cancer in the worldwide context.1,2 Over the last 20 years, new molecular insights have indicated the mechanism of tumor initiation and progression for CRC. For instance, adenomatous polyposis coli gene mutation, KRAS gene activation, and P53 gene inhibition are closely related to carcinogenesis, progression, prognosis, and treatment decision of CRC.3–6 Monoclonal antibody targeting EGFR has made significant breakthrough and great enrichment in the field of colorectal therapy. Nevertheless, KRAS mutation occurs in ~40% of CRC patients and studies have demonstrated that KRAS mutation always predicts a lack of responses to EGFR targeted therapies in metastatic CRC.7–9
18F-FDG PET/CT imaging is widely used for early diagnosis, staging, and judgment of recurrence and metastasis after surgery in CRC patients. Exploring the correlation between pretreatment images and genetic alteration is a challenging work to optimize the predictive value of KRAS mutation. CRYSTAL (chemotherapy and cetuximab in metastatic colorectal cancer) and OPUS (Oxaliplatin and Cetuximab in First-Line Treatment of Metastatic Colorectal Cancer) studies have shown that metastatic CRC patients with wild-type (WT) KRAS tumor can benefit from cetuximab treatment, whereas the KRAS mutation type patients cannot achieve benefits.10 Thus, a noninvasive imaging method to predict the KRAS mutation status, especially for patients who cannot undergo an invasive examination, is necessary and valuable. In addition, considering CRC is a heterogeneous disease, the specific location of tumor tissue may not be able to exactly reflect the KRAS mutation status of the entire tumor.11 Several studies have explored the relationship between PET/CT imaging and KRAS mutation in CRC patients. Cho et al found KRAS mutation patients were inclined to have lung metastasis and had higher 18F-FDG uptake compared to WT KRAS in stage IV CRC patients.12 Two clinical studies demonstrated that higher 18F-FDG uptake was associated with KRAS mutation in CRC patients.13,14 One study indicated that the maximum standardized uptake value (SUVmax) for the primary tumor and tumor-to-liver ratio was higher in CRC patients with KRAS mutation. Furthermore, the relationship between different PET/CT metabolic parameters and KRAS mutation status is worth exploring.
In this study, we investigated clinical characteristics and PET/CT metabolic parameters that could potentially predict KRAS mutation status in a cohort of CRC patients and verified the predictive value via receiver operating characteristic (ROC) curve analysis.
Materials and methods
Patient population selection
After obtaining approval from the Ethics Review Board, 164 newly diagnosed CRC patients who underwent PET/CT examination before primary tumor resection from 2012 to 2017 were identified in this study. This retrospective study was approved by the Ethics Committee. All patients provided written informed consent and this study was conducted in accordance with the Declaration of Helsinki. All pathologically confirmed CRC patients accepted with further KRAS mutation status analysis. No patients received preoperative chemotherapy. The median age was 56 years (range: 29–86 years). Ninety-nine patients were men and 65 patients were women. Among them, most of the patients had pathological features, including moderate differentiation, nonmucinous adenocarcinoma, and full thickness invasive depth. Regional lymph node (RLD) metastasis and late stage patients accounted for the majority. All patients were suitable for accepting PET/CT examination. The clinical characteristics of the 164 patients are shown in Table 1. Patient clinical characteristics according to KRAS mutation status are shown in Table 2.
Table 1 Patient clinical characteristics
Table 2 Patient clinical characteristics according to KRAS mutation status
PET/CT imaging acquisition and analysis
All patients fasted for at least 6 hours before receiving PET/CT examination. Their blood glucose levels were then suitable for intravenous injection of 18F-FDG. The PET images were reconstructed by attenuation and iterative reconstruction, then multi-layered, multi-imaged, and merged with the CT images to ensure image clarity. This procedure was conducted by manufacturer review workstation (Xeleris™; GE Healthcare Bio-Sciences Corp., Piscataway, NJ, USA). The SUVmax and SUVmean parameters of the primary tumor area were automatically captured and calculated. In our study, MTV was defined as the sum of the primary tumor metabolic volumes using a SUVmax of 2.5 as the threshold.15,16
KRAS mutation analysis
Pathological samples were obtained following tumor resection for analyzing the KRAS mutation status. Pathologists selected the tumor area in tissue blocks and extracted DNA from formalin-fixed, paraffin-embedded tumor tissue slides using FFPE Tissue Kits and DNeasy Blood & Tissue Kits. Polymerase chain reaction was used to amplify the KRAS exon 2 gene and the ABI 3730XL automated DNA analyzer was used to analyze KRAS exon 2 gene using direct sequencing.
Statistical analyses
The categorical variables including clinical characteristics between two or three groups were tested using chi-squared tests. The continuous covariates were expressed as mean ± SD. The differentiations between such PET/CT metabolic parameters and KRAS mutation status were analyzed by Mann-Whitney U test. We used ROC analysis to obtain PET/CT metabolic parameters' cutoff values to predict KRAS mutation status. In addition, the multivariate logistic regression analysis was used to confirm the predictive values of PET metabolic parameters for the KRAS mutation status. It is widely known that the area under the ROC curve (AUC) is defined as the predictive value and when the AUC is not <0.7 it represents a good discrimination value.17 All analyses were two-sided and P<0.05 was considered statistically significant. Statistical analyses were performed using SPSS Statistics version 20.0 (IBM Corporation, Armonk, NY, USA).
Patient clinical characteristics
We enrolled 164 newly diagnosed CRC patients who underwent PET/CT examination before primary tumor resection and pathological samples were obtained to examine the KRAS mutation status. Moderate differentiation (n=125, 76.2%), nonmucinous adenocarcinoma (n=140, 85.4%), and full thickness invasive depth (n=140, 90.9%) account for the vast majority of patients. In addition, 107 patients (65.2%) had RLD metastasis and 117 patients (71.3%) were at stage III/IV. Among the 164 patients, 72 patients had KRAS exon 2 gene mutation type and the mutation rate was 43.9%. The main mutation subtypes were G12D (n=18, 25.0%), G12V (n=17, 23.6%), G13D (n=15, 20.8%), and G12A (n=11, 15.3%). In addition, seven patients (9.7%) had G12S mutation and four patients (5.6%) had G12C mutation. The clinical characteristics of the 164 patients are shown in Table 1. Patient clinical characteristics according to KRAS mutation status are shown in Table 2.
Clinical characteristics and KRAS mutation
Patients at diagnosis had significant correlation between KRAS mutation status and distant metastasis (P=0.028). In addition, patients with KRAS mutation status showed a higher level of differentiation (P=0.055) and higher SUVmean (P=0.059) than patients with WT KRAS, although the differences were not significant. Other clinical characteristics, including gender, histologic type, invasive depth, RLD metastasis, and stages, were not significantly different between the two groups of patients with KRAS mutation status (Table 2).
Association between PET metabolic parameters and KRAS mutation
From Table 2, we found that patients with KRAS mutation status had significantly higher SUVmax (13.5±7.8 vs 11.0±5.9, P=0.023) and MTV (30.8±21.3 vs 16.3±8.4, P=0.001) than those with WT KRAS (Table 2). The quantitative difference of SUVmax and MTV between the two groups of patients with KRAS mutation status are shown in Figure 1. No significant difference of SUVmean was found in the two groups of patients with KRAS mutation status.
Predictive value of SUVmax and MTV for KRAS mutation status
In univariate analysis, KRAS mutation status was significantly correlated with distant metastasis (P=0.029), high SUVmax (P=0.026), high SUVmean (P=0.049), and high MTV (P=0.001). We incorporated these factors into multivariate analyses, and it was revealed that high SUVmax (P=0.048) and high MTV (P=0.001) were independent predictors for KRAS mutation status (Table 3). ROC curve analysis was performed: the AUC for SUVmax was 0.603 (95% CI: 0.516–0.691). A cutoff value of 8.7 was used, which maximized specificity and sensitivity (43.5% and 72.2%, respectively), then the patients were divided into groups of low or high SUVmax. The AUC for MTV was 0.772 (95% CI: 0.698–0.845). A cutoff value of 17.8 was used, which maximizes specificity and sensitivity (69.6% and 76.4%, respectively) then the patients were divided into groups of low or high MTV (Figure 2). Furthermore, KRAS mutation status was more common in patients with high MTV and high SUVmax than in those with low MTV (66.3% vs 21.0%, P=0.001) and low SUVmax (53.7% vs 37.1%, P=0.035).
Table 3 Univariate and multivariate regression analyses for predicting KRAS mutation status
Figure 2 The prediction models consist of two metabolic parameters.
KRAS mutation occurs in ~40% of CRC patients and studies have demonstrated that KRAS mutation always predicts a lack of responses to EGFR targeted therapies in metastatic CRC.7–9 Thus, for patients who cannot undergo an invasive examination, a noninvasive imaging method to predict the KRAS mutation status is necessary and valuable. In addition, considering CRC is a heterogeneous disease, specific location of tumor tissue may not be able to exactly reflect the KRAS mutation status of the entire tumor. In our study, we demonstrated PET/CT metabolic parameters such as MTV (P=0.001) and SUVmax (P=0.048) were independent predictors for KRAS mutation. MTV with the threshold of 17.8 cm3 achieved higher accuracy in predicting KRAS mutation than SUVmax with a threshold of 8.7 through ROC analysis (0.772 vs 0.603). However, SUVmean (P=0.597) did not show a predictive value for KRAS mutation status.
PET/CT imaging involves the quantitative information of tumor depending on 18F-FDG uptake, which is superior to CT or MRI that rely on the doctor's subjective judgement. Several studies have explored the underlying mechanism of the relationship between glucose accumulation and KRAS mutation status. Yun et al studied the transcriptomes of paired CRC cell lines and found GLUT1 which encodes glucose transporter-1 was upregulated in KRAS or BRAF mutations CRC cell lines. Therefore the KRAS mutant cells exhibited enhanced glucose uptake, whereas the WT cells were subjected to a low glucose environment.18 Sasaki et al also explored the correlation between the KRAS mutation and glucose accumulation in 283 non-small-cell lung cancer samples and demonstrated GLUT1, as the most common glucose transporter in cells, was highly expressed in cells with KRAS mutation status.19 All these observations may explain the phenomenon that tumors with KRAS mutation status always had glucose accumulation. Thus, PET/CT metabolic parameters may be theoretically an ideal predictor for KRAS mutation status. Kawada et al conducted a study to verify whether FDG accumulation is associated with KRAS mutation status and its predictive value of KRAS status in metastatic CRC patients.13 They demonstrated that SUVmax remained significantly associated with KRAS mutations and that it was an ideal predictor of KRAS status with an accuracy of 71.4%.12 In addition, Lee et al also depicted SUVmax and SUVpeak to be significantly associated with KRAS mutation.20 However, they did not explore whether these metabolic parameters were predictors for KRAS status. Iwamoto et al investigated the mechanisms that mutated KRAS status increased FDG accumulation and found that upregulation of GLUT1 and additive effect of hypoxia-inducible factor 1α (HIF-1α) in hypoxic lesions could cause FDG accumulation in CRC with KRAS mutation status.21
Several studies have reported the correlation between KRAS status and clinical outcomes after topical treatment of CRC liver metastases (CLM).22–25 Shady et al22 evaluated the prognostic value of KRAS mutation in patients with CLM who underwent percutaneous radiofrequency ablation (RFA) and found KRAS mutation was a predictor of poor overall survival (OS) (P=0.016), new liver metastases (P=0.037), and peritoneal metastases (P=0.015). Similar results were also demonstrated in two other studies. Calandri et al23 found 3-year local tumour progression-free survival rates of KRAS mutant subgroups were significantly worse than WT KRAS subgroups (P<0.001 and P=0.006). The same result was also verified in the research by Odisio et al, with a P-value of 0.001.24 In addition to RFA, Yttrium-90 radioembolization therapy is also an important topical treatment option for unresectable CLM. KRAS mutation was verified to be an independent prognostic factor for poor OS in patients with CLM treated with Yttrium-90 radioembolization therapy.25 Therefore, KRAS status is important for the management of the treatment of patients with CLM.
We explored the association between KRAS mutation status and different clinical characteristics in our study, such as sex, differentiation, histologic type, invasive depth, RLD metastasis, distant metastasis, and stage. We did not find significant association between these characteristics. Nevertheless, the KRAS mutation group was found to have tumors with distant metastasis (P=0.028). Our study demonstrated that a high MTV was significantly associated with KRAS mutation (P=0.001). A high SUVmax was also a good predictor for KRAS mutation (P=0.048). SUVmean was not found to be associated with KRAS mutation (P=0.597). Our study provided evidence that PET/CT metabolic parameters have an important role in the noninvasive prediction of KRAS mutation status. SUVmax was a semiquantitative parameter that could vary with different factors, such as PET scanners, plasma glucose level fasting duration, and region of interest parameters. However, MTV was a quantitative parameter that reflect the glucose uptake of the entire tumor. Thus, MTV was superior to SUVmax in predicting gene mutation status.26,27 Several studies also demonstrated that MTV was an important factor in predicting the clinical outcomes in several kinds of tumors.26,28–30
The limitation of this study was its retrospective character which existed inevitable bias. In addition, considering that WT KRAS left hemicolon cancer and WT KRAS right hemicolon cancer have different responses to cetuximab, there may be a discrepancy in biological behavior between colon cancers at different primary sites. Thus, it is necessary to analyze the association between PET/CT parameters and KRAS mutation status in left and right hemicolon cancer, respectively. PET/CT parameters were also found to be associated with neoadjuvant chemoradiotherapy response in patients with locally advanced rectal tumor.31,32 Thus, monitoring the association between the quantitative changes of PET/CT parameters and KRAS mutation status is necessary. Regrettably, we did not analyze it due to limited sample size. Furthermore, comprehensive analysis of various metabolic parameter thresholds may be a good choice in further studies. Also, future studies should use standardized protocols for 18F-FDG PET acquisition and correction of the partial volume effect or false-positive PET findings33 to augment its predictive value.
PET/CT metabolic parameters can be used for KRAS mutation status prediction in CRC patients. In our study, we found that KRAS mutation status was associated with high MTV and high SUVmax using a threshold of 17.8 cm3 and 8.7, respectively, and the predictive accuracy was 0.772 and 0.603, respectively.
The authors report no conflicts of interest in this work.
Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer. 1993;54(4):594–606.
Parker SL, Tong T, Bolden S, Wingo PA. Cancer statistics, 1997. CA Cancer J Clin. 1997;47(1):5–27.
Leslie A, Pratt NR, Gillespie K, et al. Mutations of APC, K-Ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas. Cancer Res. 2003;63(15):4656–4661.
Conlin A, Smith G, Carey FA, Wolf CR, Steele RJC. The prognostic significance of K-Ras, p53, and APC mutations in colorectal carcinoma. Gut. 2005;54(9):1283–1286.
Lièvre A, Bachet JB, Boige V, et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol. 2008;26(3):374–379.
Westra JL, Schaapveld M, Hollema H, et al. Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. J Clin Oncol. 2005;23(24):5635–5643.
Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med. 2008;359(17):1757–1765.
Jonker DJ, O'Callaghan CJ, Karapetis CS, et al. Cetuximab for the treatment of colorectal cancer. N Engl J Med. 2007;357(20):2040–2048.
Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol. 2008;26(10):1626–1634.
Bokemeyer C, van Cutsem E, Rougier P, et al. Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the crystal and OPUS randomised clinical trials. Eur J Cancer. 2012;48(10):1466–1475.
Baldus SE, Schaefer KL, Engers R, et al. Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases. Clin Cancer Res. 2010;16(3):790–799.
Cho A, Jo K, Hwang SH, et al. Correlation between KRAS mutation and 18F-FDG uptake in stage IV colorectal cancer. Abdom Radiol. 2017;42(6):1621–1626.
Kawada K, Nakamoto Y, Kawada M, et al. Relationship between 18F-fluorodeoxyglucose accumulation and KRAS/BRAF mutations in colorectal cancer. Clin Cancer Res. 2012;18(6):1696–1703.
Chen SW, Chiang HC, Chen WT, et al. Correlation between PET/CT parameters and KRAS expression in colorectal cancer. Clin Nucl Med. 2014;39(8):685–689.
Meng X, Sun X, Mu D, et al. Noninvasive evaluation of microscopic tumor extensions using standardized uptake value and metabolic tumor volume in non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2012;82(2):960–966.
Forrester K, Almoguera C, Han K, Grizzle WE, Perucho M. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature. 1987;327(6120):298–303.
Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982;143(1):29–36.
Yun J, Rago C, Cheong I, et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science. 2009;325(5947):1555–1559.
Sasaki H, Shitara M, Yokota K, et al. Overexpression of GLUT1 correlates with KRAS mutations in lung carcinomas. Mol Med Rep. 2012;5(3):599–602.
Lee JH, Kang J, Baik SH, et al. Relationship between 18F-fluorodeoxyglucose uptake and V-Ki-Ras2 Kirsten rat sarcoma viral oncogene homolog mutation in colorectal cancer patients. Medicine (Baltimore). 2016;95(1):e2236.
Iwamoto M, Kawada K, Nakamoto Y, et al. Regulation of 18F-FDG accumulation in colorectal cancer cells with mutated KRAS. J Nucl Med. 2014;55(12):2038–2044.
Shady W, Petre EN, Vakiani E, et al. KRAS mutation is a marker of worse oncologic outcomes after percutaneous radiofrequency ablation of colorectal liver metastases. Oncotarget. 2017;8(39):66117–66127.
Calandri M, Yamashita S, Gazzera C, et al. Ablation of colorectal liver metastasis: interaction of ablation margins and ras mutation profiling on local tumour progression-free survival. Eur Radiol. 2018;28(7):2727–2734.
Odisio BC, Yamashita S, Huang SY, et al. Local tumour progression after percutaneous ablation of colorectal liver metastases according to RAS mutation status. Br J Surg. 2017;104(6):760–768.
Lahti SJ, Xing M, Zhang D, et al. KRAS status as an independent prognostic factor for survival after yttrium-90 radioembolization therapy for unresectable colorectal cancer liver metastases. J Vasc Interv Radiol. 2015;26(8):1102–1111.
Ikeno Y, Seo S, Iwaisako K, et al. Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by 18F-FDG-PET is associated with the KRAS mutation status and prognosis. J Transl Med. 2018;16(1):95.
Liu A, Han A, Zhu H, et al. The role of metabolic tumor volume (MTV) measured by [18F] FDG PET/CT in predicting EGFR gene mutation status in non-small cell lung cancer. Oncotarget. 2017;8(20):33736–33744.
Chung HW, Lee KY, Kim HJ, Kim WS, So Y. FDG PET/CT metabolic tumor volume and total lesion glycolysis predict prognosis in patients with advanced lung adenocarcinoma. J Cancer Res Clin Oncol. 2014;140(1):89–98.
Yoo SW, Kim J, Chong A, et al. Metabolic tumor volume measured by F-18 FDG PET/CT can further stratify the prognosis of patients with stage IV non-small cell lung cancer. Nucl Med Mol Imaging. 2012;46(4):286–293.
Ho TY, Chou PC, Yang CT, Tsang NM, Yen TC. Total lesion glycolysis determined per RECIST 1.1 criteria predicts survival in EGFR mutation-negative patients with advanced lung adenocarcinoma. Clin Nucl Med. 2015;40(6):e295–e299.
Maffione AM, Ferretti A, Grassetto G, et al. Fifteen different 18F-FDG PET/CT qualitative and quantitative parameters investigated as pathological response predictors of locally advanced rectal cancer treated by neoadjuvant chemoradiation therapy. Eur J Nucl Med Mol Imaging. 2013;40(6):853–864.
Maffione AM, Ferretti A, Chondrogiannis S, et al. Proposal of a new 18F-FDG PET/CT predictor of response in rectal cancer treated by neoadjuvant chemoradiation therapy and comparison with PERCIST criteria. Clin Nucl Med. 2013;38(10):795–797.
Maffione AM, Chondrogiannis S, Marzola MC, et al. Biological target volume overlapping segmentation system method for avoiding false-positive PET findings in assessing response to neoadjuvant chemoradiation therapy in rectal cancer. Clin Nucl Med. 2014;39(3):e215–e219.
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Fukushima, Shigejirō. (Shōwa 37 [1962) Chūgoku Nanbokuchō shi kenkyū /Tōkyō : Kyōiku Shoseki,MLA Citation
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Chūgoku Nanbokuchō shi kenkyū /
Fukushima Shigejirō cho.
|Main Author:
|Fukushima, Shigejirō
|Tōkyō : Kyōiku Shoseki, Shōwa 37 [1962]
|Civil service - China. | Villages - China.
|China - Officials and employees. | China - History - 220-618.
University of Illinois at Urbana-Champaign
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I have lost a lot of wieght, as a consequence clothes fit me that did not before. Last summer I ordered a bunch of clothes online that were really really cheap, but despite being size 3x they didn't even remotely fit. They were more like 14-16, which is in the Large/Xlarge range. At this point things are starting to actually fit. This weekend is Kumoricon, and I haven't had time to do much cosplay building. I was just planning on going, playing DnD and taking cosplay pictures. But this jacket now sort of fits, and it is kind piratey....maybe? It had a really crappy zipper on it that wouldn't stay together even if I zipped it up without putting it on so there was no pull on it.
Update with stuffs n Things
It has been a while again. I have been so busy trying to find a job I haven't had time to do much else.
I have lost a lot of wieght, as a consequence clothes fit me that did not before. Last summer I ordered a bunch of clothes online that were really really cheap, but despite being size 3x they didn't even remotely fit. They were more like 14-16, which is in the Large/Xlarge range. At this point things are starting to actually fit. This weekend is Kumoricon, and I haven't had time to do much cosplay building. I was just planning on going, playing DnD and taking cosplay pictures. But this jacket now sort of fits, and it is kind piratey....maybe? It had a really crappy zipper on it that wouldn't stay together even if I zipped it up without putting it on so there was no pull on it.
For some reason I didn't think of getting a pic before I started working on it. First I just cut off the zipper. Then I reinforced the button area. I have pinned all the buttons on, and sewed about 3 of them. I will then make loops to hook over the buttons. I have no idea what else I will do with it. What will I wear under it? Skirt? Pants? Will it easily lend itself to being turned into a cosplay for an existing character? I dunno. It is 3/4 length sleeves. I have a ton of silver buttons. Originally I was going to put buttons on both sides and lace it together. However I do not have enough of the same kind of buttons, so I decided to do the button loop thing. I have these pirate skull and crossbones buttons. Not enough for the sleeve cuff buttons, but that is ok. I will put dragon buttons on the sleeve cuffs. The color matches. Sort of. I also found a bunch of Halloween themed stuff I bought on sale last year. I have no idea what I will do with them yet, but I am sure I will think of something.
I need to get back to job hunting. If I come up with something cool I will post it.
Excuses, Excuses
Another month has gone by. I suppose it is time to update this.
I have been working on audio, but I have a limited amount of time I can work on it, and I don't yet have anything I am willing to post. I will probably work some more on it tonight.
One of my favorite geek bands, Debs & Errol, were in the running for the CBC Searchlight. Errol wanted to do something with the #Votegeek hashtag, and called for fans to send him pictures of themselves with it. So I dusted off Wade and ran around town taking pictures. I also decided to take this as an excuse to actually build him a set. He needed furniture, big time. Everything I have is simply Liliputian compared to him. Here is one of the pics I took at Dutch Brothers. They are so awesome there.
So, anyway, I took a few days a built Wade a sofa and an end table and a coffee table. I sewed a cushion and crocheted a blanket to go on the back of the sofa. I painted a background. So now that I had all these things, of course I had to play around with them. The resulting videos are not great, but the set looks awesome. Needs more detail, like pictures, a window, a book shelf, etc. Otherwise I am happy with it. Here is the mess I call a video...
Dinosaurus from Barefoot Hallucination on Vimeo.
So, there ya go. This month hasn't been completely uneventful. As I play with Wade and what he can do I hope to have more test videos to post.
Busy as a beav...er, bee
Well, it has been a very productive weekend. I haven't finished recording and posting stories yet, but it still has been very productive.
I spent several hours yesterday rewriting the story arc for the webseries. This is re-write number 3. Re-write because the direction it was going has changed so dramatically I had to go back and change the first few episodes and reconfigure the story arc. For some reason this time my characters are telling me where they want go with it, and it is not what I had in mind at all. However, it is truer to the characters themselves, so I guess I don't mind the rewrite. It is also necessitating the addition of more great characters, so I starting losing track of it all. And little jokes, story threads and character interactions are popping in, giving little touches to what was a good silly little story thing. It has become more than I meant it to be. I do not think it is bad. But it really isn't what I had in mind when I started this. it is tons better. I just hope I can make it fully to fruition.
One thing I noticed was I kept having to flip around through my notebooks to make sure I was referencing each character correctly, and not leaving dangling story threads through out. I found cheap foam board at the Dollar Tree, which I had planned to use for light bouncing. I decided that having everything easily accessible was a better idea.
So now, my walls look like this:
I just taped the foam board to the walls using packing tape. I will still be able to use the other side for lighting. I also am saving a few to put animation notes on. As crazy as it looks, it is actually helpful. I have never been in a writer's room, but after I did all this I realized this room now looks like pictures I have seen on the intertubes. So maybe I am on to something. Probably a lot less efficient, as it follows my logic not general conventions, but still. Sitting back and looking at it all I feel like I actually accomplished something. And I feel that much closer to this thing becoming a reality.
Also this weekend my friend drove me to the hardware store so I could purchase some supplies. I bought plywood, 1x1, 1-1/2x1/2, etc. I glued and nailed the boards together for a frame, then I glued and nailed the plywood to the top. Once it is dry I will have a base I can clamp to the table and attach a background.
Here are some pics:
So that's now done. I also purchased some small pieces of sheet metal. I am still figuring out what exactly I want to do with them. One of the ways I anchor my puppets is by using magnets. Unlike some, I put my magnets in the feet and use a metal base. Even if I feel the need to go the other way with my new puppets, a sheet metal base for the floor will give extra stability. I just haven't exactly decided how to execute it yet.
So that was my weekend. I still have a ton to do, but I feel like I am moving forward instead of stagnating.
Progress....sort of
Well, yes, I have been working on my video. The one I am making completely (well, mostly) on my iPad. I have gotten some people to collaborate and help record voiceovers. I tried to do both voices myself and it sounded like the same person for both characters. I really need to learn how to do voices. Anyway, so now I have all the audio I need. Well, mostly. I may have to rewrite the script a bit, as I am having a hard time finding a particular soundbite that is integral to the plot. But anyway, I probably would be shooting today, but I got distracted. I have been dividing my time between this and a new project. Yesterday someone at work brought in a bunch of stuff she had cleaned out of her son's room. This was included in the bunch:
It is a little bitty baby guitar. At first I was going to just restring it as a guitar, as 2 of the strings were broken and I had my doubts about the remaining ones. Then I went to the uke store for strings for my soprano uke and the guy suggested I string it as a concert uke. It is exactly the same size and shape. The biggest differences being the part at the end that holds the strings and more tuning pegs. So, while I have been working on my video stuff, I turned that ugly orange thing into this:
It is kind of hard to see. The light also makes it look lighter than it is. But I painted it green with silver trim, and painted the bridge black with silver trim. I also had to glue a piece of wood under the metal string holder. I found out the hard way that the metal eats through nylon strings quickly. Like, within minutes of stringing it and while trying to tune it. If I didn't have my glasses on at the time I would have put my eye out. I have strung it like a concert uke, and with a low G instead of a high G. It is interesting to listen to. Definitely changes how my chords sound. The strings are still acclimating. It will take a bit before they stop stretching and settle in.
But yeah, I would paint a bit, then work on video while the paint was drying, then paint some more. I probably would be farther along on the video if I could just leave this thing alone. But I can't. It's my new toy.
Tonight I am tired of doing stuff, but tomorrow I will get to shooting and editing. My plan is to have it completely done by sundown tomorrow. That is the plan. We shall see what actually happens. :)
Finally! I knew if I put my brain to it I would find something that worked. It is still a teensy bit shakey, but I will use it anyway. After several false starts, this is the apparatus I ended up with:
Yes...that is balsa wood square doweling, the first attempt at the bookcase the other day, rubber shelf webbing and a packing peanut. I feel like fucking McGyver right now. One of these days I will have the money for tools so I can build more permanent solutions to these problems. For now.....it's McGyvering.
So here is how it turned out:
Not perfect, but good enough to use. :) Now on to scene 2. That one will be simple for camera angles...I can just place it on the set floor...but it will be a bear to figure out how to get them to move how I want.
For now, bed. Work early in the morning.
Eleanor...nerd, musician, stop motion animator, techy, crafty. But not in the crafty crafty way...I just like making things. You can find me on Twitch, Twitter and Periscope @TeaWeaselStopMO.
If you feel like contributing to help me upgrade equipment or pay for building supplies, feel free to click this button. Anything you contribute is appreciated muchly.
February 2019


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Nine trapped in collapsed Shanghai buildingChina | 16 May 2019 3:42 pm
At least nine people are trapped in a building collapse in Shanghai. The city's rescue service said the building in the downtown Changning district was undergoing refurbishment to convert it into an auto showroom when it gave way around 11:30 a.m. today.
It said 24 emergency vehicles and more than 150 personnel responded. By early afternoon, 11 out of the 20 people buried in the collapse had been pulled from the rubble. Their conditions were not immediately known.
China has suffered a spate of industrial accidents in recent months.
A major fire in Shanghai in 2010 destroyed a 28-story apartment building that was under repair, killing at least 58 people. Authorities blamed sparks from a welder's torch.
Today's Standard


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MLS #1514458 Official listing information! Sweetwater Est Ph 1 Sec 1 neighborhood - 1845 Lochlann Dr located in Culleoka TN 38451, priced at $29900, with bedrooms.1845 Lochlann Dr Culleoka TN - MLS #1514458 Close
Land for sale in Culleoka, TN at 1845 Lochlann Dr. This land is priced at $28,750/acre.
Very Pretty Location surrounded by grassy hillsides. Underground utilities and curbed streets, lot sizes range from1 ac to 3+ ac.
The data relating to real estate for sale on this web site comes in part from the Internet Data Exchange Program of RealTracs Solutions. Real estate listings held by brokerage firms other than The Ashton Real Estate Group of RE/MAX Advantage are marked with the Internet Data Exchange Program logo or thumbnail logo and detailed information about them includes the name of the listing brokers.
Disclaimer: All information is believed to be accurate but not guaranteed and should be independently verified. All properties are subject to prior sale, change or withdrawal.
Copyright 2019 RealTracs Solutions.
Listing information last updated on September 20th, 2019 at 6:57am CDT.


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Turkey is a nation straddling eastern Europe and western Asia with cultural connections to ancient Greek, Persian, Roman, Byzantine and Ottoman empires. Cosmopolitan Istanbul, on the Bosphorus Strait, is home to the iconic Hagia Sophia, with its soaring dome and Christian mosaics, the massive 17th-century Blue Mosque and the circa-1460 Topkapı Palace, former home of sultans. Ankara is Turkey's modern capital.
Day 1 Cappadocia
Arrive to Istanbul and transit connection to domestic sector for your flight to Cappadocia. You will reach Cappadocia in the afternoon after a short duration of 1hr flight. Balance of the day at your leisure.
Meals : Dinner (Hotel)
Day 2 Cappadocia
Depart your hotel for a Full Day tour in Cappadocia. Visit Goreme Open Air Museum in Goreme Valley to see the early Christian churches decorated with unique frescos depicting various scenes from the Bible. Visit Pasabaglari (Monk's Valley) to see the world famous fairy chimneys which have unique shape. Later you will visit Avanos, the very well known pottery and craft center since Hittite times. Enjoy hand made ceramics, fashion design jewelry Average Pick-up time: 09:00 Approximate Tour Duration: 08 hrs
Meals : Breakfast – Lunch (local) – Dinner (Hotel)
Day 3 Istanbul
Check-out from your hotel with your luggage, your tour will take you to Kaymaklı Underground city ; even though the whole city has not been completely opened, and since only 4 floors have been uncovered. It is accepted as the widest underground city of Cappadocia, among the explored ones. The number of the storage rooms in such a small area supports the idea that a great number of people resided here. Archeologists think that this could have been up to 3500 people. Flight to Istanbul
Average Pick-up time: 09:00 Approximate Tour Duration: 05 hrs Meals : Breakfast – Lunch (local)
Day 4 Istanbul
Enjoy a Full day tour of Istanbul includes Hippodrome, the place chariot races and competitive athletic events took place during the Roman period. Blue Mosque; a 17th century Ottoman Mosque famous with its six minarets and magnificent interior with blue tiles. Later St Sophia – the great Byzantine Basilica built in the 6th century, which remained the largest cathedral in the world for almost a thousand years. Visit Topkapi Palace, residence of Ottoman Sultans housing the richness of 700 years. Finally the Grand Bazaar, world famous shopping arcade with over 4,000 shops under one roof.
Average Pick-up time: 08:15-08:45 Approximate Tour Duration: 08 hrs Meals : Breakfast – Lunch (local)
Day 5 Istanbul
Tour starts in the morning with a visit of Spice Market, the last stop of Silk Road where today still the various types of spices, Turkish delights, Turkish coffee, herbal teas and souvenirs are offered. . By this tour, you will make cruise on Bosphorus by public boat along the Bosphorus, the winding straits separating Europe and Asia. At both sides house the Imperial palaces, kiosks, pavilions, gardens and today´s million dollars of mansions will be seen. Tour ends in the city without drop to your hotel.
Average Pick-up time: 08:15-08:45 Approximate Tour Duration: 04 hrs Meals : Breakfast only
Day 6 Departure
Pack your luggage and say good-by to your new friends.
Meals : Breakfast only


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Ancient Nuclear Warfare Gallery
Ancient Nuclear War
31/10/2014 18:21
Sticks and stones may break my bones but names will never harm me... When insults and threats no longer held promise, we picked up sticks and stones and followed through with our intentions and began to beat our enemies. When others seen this, They collected bigger sticks and...
Who's Your Favorite Cast Member?
Robert Clotworthy (519)
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Ancient Merchant Cart
gods, Aliens
Technologically Advanced Ancient Civilizations?
Neither this Website nor any view or opinion expressed in it, nor the context in which the Ancient Astronaut Hypothesis and its application, to any likeness of Ancient Aliens™, is approved or endorsed by, or is in any way associated with the production company, Prometheus Entertainment™, or A&E Television Networks™, The History Channel™, or anyone else connected with the making of the television series Ancient Aliens™.
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Ancient Alien History Toronto, Ontario Canada email@example.com


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On the nose it has a warm inviting beurre noizette (burnt butter) and roasted almonds from the time spent in the wood. Fresh ripe pineapple and green flavours follows onto the palate. A well balanced and complex wine combining fresh citrus and classic rich buttery Chardonnay aromas.
This Chardonnay is made from 50% of our Franschhoek estate grapes and 50% from Elim (Agulhas).
Grapes from different sites picked seperately and at different sugars to highlight differences in our terroir.
Matured in 1st 2nd and 3rd fill barrels for 7 months. Barrels stirred every second week for 3 months.
please select a country


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Villa - Polop - 379.000€
Ref. 526DA
Ibiza-style villa with excellent sea views in Polop
Project for the construction of a modern design villa with high quality finishes, distributed on two floors and with excellent views to the sea. The ground floor consists of three bedrooms, all with fitted wardrobes and two bathrooms of which one en-suite. The upper floor consists of a spacious and bright living room and dining room combined, a partially open kitchen with all appliances included, a nice entrance hall and a guest toilet. The villa stands out for its large windows that provide a lot of natural light. From the living room we have direct access to the pool and the garden which consists of beautiful palms and native trees. Outside, we also find a pretty terrace with a nice shade on the hot summer days. The villa also has a spacious solarium of 40m2 and private parking. In addition, it is equipped with water softener, motorized blinds, security doors, PVC doors and windows with double glazing, wardrobes lined interior and exterior lighting, central air conditioning preinstallation, underfloor heating in bathrooms, outdoor shower, gardening and scheduled irrigation. The furniture is optional.
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Welcome tot the property data sheet of the property you have selected. In this data sheet you will find the most obvious charasteristics of the house. In most cases there is more and our sales team can inform you exhaustive about all ins and outs of this selection. Just fill out the contactform on this sheet or contact us by telephone. If you contact us, please keep the reference number of the property by hand. Our sales agents can inform you about similar properties, costst and urbanistic facts. Please read our buyers page to find out more to know when buying real estate in Spain. If you want to know more about our company Moraira Invest Group you can download our brochure. If you want this sheet on paper you can print it out by pushing one of the print buttons on the right or E-mail it to people who may interest it. For privacy reasons we cannot publish the exact adress of the real estate. Most of the time we mention an area. To visit the property you have to make an appointment with one of our agents. During this visit the agent can explain you everything about the house and neighbourhood. If you still are orientating maybe a visit to our office can help you. Our agents take all the time to tell you about the possibilities within your wishlist which will rsult in a list of houses to visit. Our advise is to take time for the visits. The amount of impressions you get takes time to digest. Or maybe you are one of the lucky ones meeting this love on first sight house. We hope to see you soon in person and let us proof that we are THE real estate agent you want to buy a house with.


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How to Love, Foreal.
It's a lot of fake "love" going around. A lot of y'all pretending to care, love and support others when really that's not how you feeling deep down inside. Why are you projecting false feelings onto others? Why are you not being real with yourself?
Or, why do you feel the need to stick around people who aren't capable of supporting or loving you fully?
As a single woman I feel this wayy to often, the moment that I say how I feel it's "Your crazy", "Why you in your feelings?"
Simply, either what you just said or did, has made me feel a way and I'm letting you know that, as I should…
Previously, me being in my feelings WAS problematic because I was very very toxic at one point. I had a lot of wants and needs that were unrealistic and could have been damaging to the other party and at this point, I obviously get that.
Back to the current though,
AM I NOT ALLOWED TO BE IN MY FEELINGS IF I CHOOSE TO? OR AM I SUPPOSED TO KEEP THEM DORMANT AND BE A ROBOT? Men, or boys I should say, seem to want a woman who does as they say, doesn't express themselves (complain) deal with their shit remaining faithful when it's not nearly being reciprocated. Sounds like you want a fool…
If we being real, that ain't love, IT'S TOXICITY.
It's a toxic individual attempting to control you because they have not healed.
People should be able to express themselves without receiving backlash for it. We are adults and we should always be able to have a CONVERSATION and come to a common ground regardless of opinions/ differences.
Love cannot be mistaken for anything other than what it is, love can not be replicated, and if it is guess what, it will fold in the light.
Real love is two people making a vow to one another. A commitment of trust, compassion, communication and understanding. Love is beautiful but also complex in the sense that you cannot be SELFISH. That person's feelings now becomes a priority.
Ya'll don't be ready and willing to do none of the above and wonder why you in the situation you in. A lack of the above equates to painful, toxic relationships and that ain't in CHIEF!
You liking me and liking the idea of me is two VERY different things. I feel like most men I've came across are fearful to commit and may feel challenged dealing with a woman of my caliber but hey, that's none of my business.
I'm intelligent, I know what I want and I make it clear. I hustle, provide for myself and strive for more than the average. Not to mention I'm a healing woman who knows her worth,
I'm lethal. 💎
Either you level up or get left behind, very simple.
You coming into my life is an honor, and I'm gonna make you feel, and remember that every second from a natural and humble state.
The vibes speak for itself….
Loving others isn't easy as I said. It's commitment, and sacrifice for one who you believe is WORTH IT.
Loving someone is,
Understanding their love language- *IMPORTANT* Don't compare your ex's to the person you're dealing with currently, they are not the same. Everyone has different ways of wanting to be "Loved" and you have to get that shit down to a science which is why is CRITICAL to "get to know someone" in the beginning. Don't SKIP STEPS, learn that shit and SATISFY YOUR PARTNER/ FRIEND ETC.
My love language is attentiveness and communication. I love when I can talk to others and if a problem/ discrepancy comes up it can be solved by just taking time to COMMUNICATE in a gentle way. I also don't like being ignored or blow off so if the reason is being communicated then for the most part we are good. What's not discussed is not known…
I find it really attractive when you can capture a man's attention and it not be sexual. I like engaging in meaningful conversations that ignite my soul. Let's talk about it boo, fuck my mind before my body.
Being patient + understanding- Some of us are on a journey of healing, just because you like/ love someone and they aren't there mentally/spiritually doesn't mean you give up on them and kick them to the curb. If someone is really worth it, you fight. Remain patience and gentle with that person. They may need you more than you think…
Be TRUTHFUL- Lying literally gets you NOWHERE and if you're a liar you KNOW THAT. Why lie when you can just tell the truth and potentially fix what you damaged? No progress is made when lies are told. Why even waste your time being with someone if all you gonna do is lie and CHEAT. Just be a HOE. Adults respect honesty so please keep it 100.
Be compassionate- This goes hand in hand… how can you love someone if you have a lack of compassion? What is compassion? - "Someone showing kindness, caring, and a willingness to help. This is a word for a very positive emotion that has to dowith being thoughtful and decent."
AND THE REALITY IS A LOT OF YA'LL AINT EVEN DECENT. You ignore others, blow off dates without any communication that you are doing so, have a lack of or regard for their feelings, put in inconsistent efforts to keep them on a string for your own selfish needs and talk down about the ones that had your back.
THAT'S YOU NOT BEING A DECENT HUMAn being.
There's a lot of people being dogged out when they've exercised nothing but good intentions to others who are doing the damage. Cold hearts are just people who are miserable because they haven't dealt with their PAIN yet and don't know where to project it.
Deal with your shit.
5. Commitment- Commit in the sense that you understand you are not getting any older. You KNOW you want to spend your life with someone who completes you. The goal is always marriage, (typically for mature adults lol) I mean if it's anything else it's extremely temporal. Commit to being truthful. Open and forthcoming about your feelings etc. BE EMOTIONALLY AVAILABLE. Devote time to BUILD. That means answering phone calls and texts…
How does one get to know each other if you don't even make yourself available?!
In the process of waiting for your hubby/wifey you have to DATE. And that's ok because it comes with the process. By knowing yourself you'll know more quickly who's for you and who AIN'T. Therefore you can stop wasting TIME.
And that there is one of the reasons why I actually enjoy being single. I'm not in a place where I'm willing to settle and it reflects in my actions etc. I'm steady learning and getting to know myself, my capabilities, want's, needs, and what the fuck I will and WILL NOT TOLERATE.
YOU GOTTA KNOW WHAT YOUR "DEAL BREAKER" Is
BUT, if the goal IS marriage, WHY ARE YOU NOT STARTING OFF ON THE RIGHT FOOT OF BEING COMMITTED TO THE PERSON YOUR TAKING TIME OUT YOUR DAY TO GET TO KNOW? UNLESS YOU JUST LIKE WASTING YOUR TIME. 🗣
In 2019 and beyond I hope we can start to take people more seriously instead of blatantly wasting others time. It don't and won't always end in a relationship or the love of your life BUT that doesn't mean you can't just enjoy that person for who they are. You might catch a vibe, you might get a friend, a lover, a husband or a wife. Either way you're still getting something worth your while and that's exactly how it should be.
8 Crazy Things Love Does To Your Brain, According To Science- Via Huffington Post
"Love really is like a drug. Love can strengthen your empathy and ability to process emotions. The type of love that's cultivated through the practice of loving-kindness meditation activates the brain's empathy and emotion-processing centers, while also reducing activity in brain areas associated with self-focused thought. Loving-kindness meditation also gets us in touch with our feelings by increasing gray matter volume in brain areas associated with emotion processing."


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In his talk, Miguel reveals some ways to optimize the interaction with clients and involve them in the development of the product. Learn practical strategies to collect and apply customer feedback. Miguel Reis' tips are useful to sales, customer support, and digital marketing teams, among others.
About the speaker:
Miguel Reis is a Senior Product Manager at WeDo Technologies. His role covers overseeing the Risk Management product portfolio. In the past, Miguel worked in Product Management, Professional Services and Software Development, working for SaaS companies. During that period, he built products for Business Intelligence, EDI and Electronic Invoicing.
//This talk was given by Miguel Reis at the Productized Talks @ OLX Group (25th October 2018)
Discover our next meetups at meetup.com/Productized


text: Hi, I?ve have been experimenting with the notion of binding data from C/C++ to LUA on a binary executable level. This would allow LUA scripts to access C/C++ data without having to maintain any binding code in the host program. Since I?m mostly familiar with MSVC, I started with it on Windows. MSVC.net 2002 comes with the DIA SDK. This allows you full access to the symbol database, or better known as PDB files. The PDB file contains the debug information for a program including all memory addresses, type information for all variables, classes, functions, and enumerations. Well basically any information you normally access in the debugger is stored there. This gives us a blueprint of the entire program in memory and gives you everything you need to safely manipulate your program from LUA without writing any extra code or setup. I?d like to report that I?ve got a basic example working - the features are currently very minimal. It only supports basic data types on the global scope. Obviously this is not complete, and very few people would want to ship out software with your symbol tables, but certainly this does open the door to many different options. I plan to expand it to support functions and more complex user data types. You can grab a link to the example program here. http://www.fscnation.com/~glo/CP/CPB.zip - Check out test.lua I would love some feedback if you might find something like this useful. (firstname.lastname@example.com) At least from the quickly and dirty perspective it is nice to simply link in a library, hit the compile button, and magically have every variable, function and class accessible from LUA with just a few lines of code. Thomas ---------- note: You may need to first register msdia71.dll . On the command prompt type "regsvr32.exe msdia71.dll" if the example exe doesn?t work For example: Let?s say you have the following variables in your program. int cp_Int = 111; short cp_Short = 222; In your LUA script you can do the following CP_OpenPDB ("CPTest"); CP_BindVariable("cp_*"); -- Binds all variables that starts with ?cp_? CP_ClosePDB(); And do the following in LUA CPTest.cp_Int = -133 Your variable in the C Program will now be updated.


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2019 Riverside County State of Education Address Content
Opening Remarks
It is my honor to share with you today many of the accomplishments, challenges, and next steps for education in Riverside County.
Understanding What's Happening in Education Today
We are here today because we believe in the power of public education and are unified by our collective talents, resources, and passion with the purpose of achieving success for all students.
Never Give Up
In Riverside County, it is part of our pledge to never give up on preparing students for college and the workforce.
Intentional Innovation
The power of the arts on students is having an unmistakable impact on the development of students both inside and outside of the classroom.
Innovative Solutions
Developing innovative solutions to vexing problems will take creativity, collaboration, and a compass to navigate change.
With input from students, parents, staff, and community members, the LCAP is the road map to increase student performance in an open and transparent way.
All of these initiatives are in service of our youth.
Intentional Action. Deliberate Service.
In light of our theme, Intentional Action and Deliberate Service, I encourage you to pause right now, and write down the name of one student at your school.


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CompuSystems and SECO International Agree to a Three-Year Deal
Downers Grove, Ill. – 2/28/18 – CompuSystems has been selected by SECO International to provide full-service registration, analytics and lead management services for their annual event, SECO, in 2018, 2019 and 2020. SECO is the leading source of world-class optometric education in the United States and is widely acknowledged as the largest optometric educational meeting in the world. It attracts national and international eye care professionals, vendors, and allied ophthalmic personnel. The 2018 event will be held Feb. 28 – March 4 at the Georgia World Congress Center in Atlanta.
"We are pleased to add SECO to our portfolio of medical events," said Chris Williams, President of CompuSystems. "We look forward to providing them with the exceptional service and technology for which we are known."
About SECO: Thousands of eye care professionals all over the country call SECO their main source for continuing education and career development. Those that attend are provided with the precise knowledge, information, ideas and connections needed to elevate their practice and further their career. For more information visit: www.attendseco.com
About SECO International: SECO International, headquartered in Atlanta, Georgia, is a not-for-profit membership association founded in 1923 and counts as its members practitioners in the 12 southeastern states of Alabama, Arkansas, Florida, Georgia, Kentucky, Louisiana, Mississippi, North Carolina, South Carolina, Tennessee, Virginia and West Virginia. For more information visit: www.secointernational.com
About CompuSystems: CompuSystems is a leading provider of registration, data management and lead retrieval services. Our mission is to help event organizers, exhibitors and attendees achieve the best possible trade show experience. For more information about CompuSystems' industry-leading services.
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David Cirillo, Integrated Marketing Specialist
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