text:
About Phpactor
Phpactor is an intelligent code-completion and refactoring tool for PHP.
- Code Completion: Provides broad and accurate context aware code completion.
- No indexing: Phpactor works in real-time and is optimized with composer. It is fast.
- Introspection: Jump to class and method definitions, find references.
- Refactoring: Move classes, complete constructors, implement contracts, generate methods, etc.
- Native VIM plugin: Lightweight VIM plugin.
- CLI interface: Most/some functionality is exposed through CLI commands.
Phpactor can be used in a limited way as a standalone application, but its full power can only be utilized through its RPC protocol. It ships with support for VIM and there is also a plugin for Emacs.
Phpactor is pronounced "factor", as in "factorisation" and "re-factoring". It is a large project and some parts are more fully realised than others but it is used as an essential tool in day-to-day PHP work.
Phpactor is made up of a few different packages:
- phpactor/class-mover: Find and update class references.
- phpactor/class-to-file: Convert files to class names and vice-versa.
- phpactor/code-builder: Library for creating and idempotently updating source code.
- phpactor/code-transform: Transform code.
- phpactor/completion: Completion library.
- phpactor/path-finder: Simple for file relationships when they share common path segments.
- phpactor/source-code-filesystem: Manage source code trees.
- phpactor/test-utils: Shared test utilities for Phpactor
- phpactor/worse-reflection: Static source reflection library.
Depends On
Phpactor stands on the shoulders of some other packages:
- Couscous: This documentation is generated with Couscous.
- Jetbrains PhpStorm Stubs: Built in PHP classes are supported through this stub collection from PhpStorm.
- PHPBench: For tracking performance.
- PHPUnit: The de facto standard PHP test framework
- Symfony: The command line application is built with the Symfony console component.
- Tolerant PHP Parser: Large parts of Phpactor are integrated with the TPP.
Influenced By
- BetterReflection: Phpactors reflection API was heavily influenced by this library.
- Language Server Protocol: While not implementing the LSP, some terminology has been borrowed from it.
- Nikic PHP Parser: The original Phpactor used this before switching to TPP.
Similar Projects
- PHP Language Server: An LSP implementation for PHP.


text:
- Correction
- Open Access
- Published:
Correction to: Classification, substrate specificity and structural features of D-2-hydroxyacid dehydrogenases: 2HADH knowledgebase
BMC Psychiatryvolume 19, Article number: 221 (2019)
The original article was published in BMC Evolutionary Biology 2018 18:199
Correction to: BMC Evol Biol
Following publication of the original article [1], we have been notified that some important information was omitted by the authors from the Competing interests section. The declaration should read as below.
One of the authors (WM) notes that he has also been involved in the development of state-of-the-art software, data management and mining tools; some of them were commercialized by HKL Research.
None of commercial software was mentioning in the paper but because knowledge gained during research may be in future used in commercial software, WM has disclosed a financial interest in this research as WM is the co-founder of HKL Research and a member of the board.
The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
- 1.
Matelska, et al. Classification, substrate specificity and structural features of D-2-hydroxyacid dehydrogenases: 2HADH knowledgebase. 2018;18:199. https://doi.org/10.1186/s12862-018-1309-8.
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

subset: commoncrawl


text:
I have been instructed by forum post and by SCP article comment that my SCP is safe and that its Keter. I put it in the middle, but wanted to see what the community on the whole thinks.
I am open to any other critisism or advice as well. I'm pleased with how this turned out for a 1st post, but there have beena lot of downvotes as well, so I figure it has room to improve.


text:
The Bold and The Beautiful Transcript Monday 9/26/11
Provided By
Proofread By Emma
Eric: It's good to have you here. My youngest son, my namesake-- Eric Forrester Jr. is home.
Brooke: Please tell us you're here to stay.
Rick: How is it I can never say no to you?
Eric: (Chuckles)
Brooke: (Laughs)
Liam: (Sighs) You make it sound so simple.
Steffy: Because it is. You don't have to be in some kind of dictatorship marriage.
Liam: Move up the wedding. That's--it's the one thing I asked. Move up the wedding.
Steffy: You know what the worst part is? Is that she could have said no, but she agreed to it. I mean, she must just want to string you along and make you feel like you're actually part of that relationship.
Liam: Yeah, she promised.
Steffy: But then she broke her promise. She will fit you in when it's convenient to her. Liam, don't make that your life.
Rick: I don't know, Mom. You know, things are going really well for me at International.
Brooke: But L.A. is your home, and we've missed you.
Rick: I've missed you, too. You know how much I love Paris. Okay, I'll stay for a while at least.
Brooke: Yes! (Laughs)
Eric: (Laughs) Good. Hear, hear.
Brooke: Your room is just the way you left it.
Rick: All right, all right, all right. Do you want me to stay because you miss me? Or is this an empty-nest thing because Hope's getting married?
Brooke: Oh, well, a little bit of both.
Eric: (Chuckles)
Rick: So you're happy? This Liam's a good guy?
Eric: He is a good guy. He's a fine young man.
Rick: Mm.
Brooke: You've met him before.
Rick: Barely. You're not worried? Being Bill Spencer's son?
Eric: He's not like Bill.
Rick: If you say so.
Brooke: (Sighs)
Rick: I guess I'll have to find out for myself. I got invited to his bachelor party.
Brooke: Ooh. Well, once you get to know him better, you'll really like him. He's good for Hope, and she adores him.
(Cell phone alert chimes)
Steffy: Is it Hope?
Liam: No, it's my dad. It's info about tonight's bachelor party. Yippee. Well, it's getting started soon. I better go get ready.
Steffy: Hey, uh, Liam?
Liam: I heard what you said. It's a lot to think about. I just... I need time.
Steffy: Well, then take it. I want to give you all the time you need.
Steffy: (Sighs)
(Cell phone rings)
Steffy: Pick up, pick up, pick up.
Bill: Can you hear me now?
Steffy: Hey. Oh, my-- hey, did you see Liam out there?
Bill: No, I didn't see him.
Steffy: Oh, well, you-- I think you should go after him.
Bill: Why?
Steffy: Hope decided not to push up the wedding.
Bill: Oh, I knew it.
Steffy: What? That he was so excited about this? That Hope made a promise and then decided to go back on it? You know what? I am just so sick of this. I cannot stand the way she uses him.
Rick: Tell me, Dad. How is Stephanie?
Eric: Well, she's fighting cancer, Son. It takes its toll.
Rick: Is she still involved with helping the homeless?
Eric: Yeah, she's very involved in doing her good works. (Chuckles) But she's the same-- she's her same old tough self, fighting her battles.
Rick: So things are good? And you're really fine with this Liam?
Brooke: Yes. Hope adores Liam, and he feels the same way about her.
Eric: He's gonna be a very supportive, loving husband.
Rick: Okay, I'll give him a chance.
Eric: Good.
Rick: Because you both seem to like him. But I'll be watching, making sure he's doing right by my little sister.
Brooke: (Chuckles)
Rick: It's just so weird, you know? Being away from all of it. (Sighs) I just had this impression of him that he was this thoughtless jerk that just was using Hope. It's gonna be hard to keep an open mind.
Eric: I get how you're feeling. I mean, he's Bill Spencer's son. Of course you'd be a little suspicious.
Brooke: (Sighs) Liam is not at all like Bill. Honestly.
Rick: He works with his dad.
Eric: Yes, he does. Like any good son, side by side, in the same building, not halfway around the world.
Rick: Ha ha.
Eric: I'm serious, Rick. I appreciate very much all the good work you did at International, and I know how much you love it there, but we all want you back here.
Rick: "All"? Even Ridge? How about Thomas and Steffy? I don't exactly have a fan club here. You know, people actually like me at the Paris office.
Eric: I know they do.
Brooke: That's good. But it's been a long time since you've been here, and I think that everybody would welcome you back. This is your home. We want you back here. I hope you'll just consider it.
Bill: Getting married shouldn't be dragging my son down, but it is.
Steffy: You know, that's exactly what I told him, but he thinks once they get married, things are gonna change.
Bill: (Scoffs) Not likely. More and more, I think the girl has issues.
Steffy: Well, in all fairness, I think Hope as gone through an awful lot because of Brooke.
Bill: Yeah, and I don't want my son being part of that.
Steffy: Well, good luck getting him to call it quit.
Bill: And now I have to attend this--this bachelor party that I'm throwing and pretend to be happy about it.
Steffy: (Sighs) I know. I know. Like, everything is just so wack.
Bill: You know I'd do anything for my son. But how do I save him from himself?
Steffy: I don't know. I-I-I've tried everything. I just--I don't know what I could do now.
Bill: Don't give up.
Steffy: I think you know me better than that. But I'm not gonna push.
Bill: No, he's gotta come to this decision on his own.
Steffy: Well, you're not giving up, ether.
Bill: That girl is wrong for him. And this--this waiting nonsense is killing his image. Worse than that... (Sighs) It's destroying his self-confidence. The kid is miserable, and I can't stand watching that. Until this wedding happens... Of course, it hasn't happened yet, and maybe it won't.
Hope: What are you doing here?
Brooke: I just wanted to check in on you.
Hope: Okay. Well, come on in.
Brooke: I wasn't sure you were here. I didn't see your car outside.
Hope: Ahh, that is because I had Madison drop me off. I want Liam to be totally surprised, and if he sees my car, he's gonna know that I'm here.
Brooke: So when he walks through that door...
Hope: Mm-hmm. I will greet him with a kiss, and he will be so excited and happy to see me.
Brooke: Even though he might be upset that you're keeping the same wedding date?
Hope: I will tell him that the wedding date doesn't matter. We are together. We are committed, and as far as I'm concerned, we are married already. And then I will take him by the hand, tell him I want to move in, and that the honeymoon starts tonight.
Brooke: Oh. (Laughs)
(Indistinct conversations)
Justin: Hey, the guest of honor.
Marcus: Yo, Liam.
Liam: How are you, Justin?
Marcus: How you doin', Man? What's new with you? You ready for the big day, or what?
Liam: Uh, yeah, you could-- you could say that. (Laughs) Yeah, right.
Justin: (Laughs)
Oliver: Happy for you, Man.
Thomas: For the bachelor.
Liam: Oh, thank you. Wow.
Thomas: Cheers.
Liam: Cheers.
(Glasses clink)
Liam: Yes.
Oliver: Cool of your dad to rent this place out, right?
Liam: Yeah, he--he-- he doesn't exactly do things simply, does he? (Chuckles)
Thomas: Uh, Rick's here?
Marcus: He is. I just heard he got back from International. Yo, Rick.
Rick: Hey. (Chuckles)
Marcus: What up?
Liam: Hey.
Rick: Liam, welcome to the family.
Liam: Thank you. Thank you.
Rick: I look forward to gettin' to know you better.
Liam: You, too. Yeah. Uh, excuse me one second.
Oliver: What's up?
Rick: How you doin'?
Justin: How you doin', Man?
Steffy: Hey, Dad. I got a haircut. Do you like it? Bruno did it. I wanted something different.
Katie: Cute.
Steffy: I have nothing to say to you, Katie.
Katie: That's okay, because I have plenty to say to you.
Brooke: But you don't even know when Liam's coming home.
Hope: He'll call.
Brooke: (Laughs) He's going to a bachelor party that Bill planned. They're probably on a jet on their way to Vegas right now.
Hope: Uh, then he'll definitely call, because he knows I want to talk to him. He just doesn't know why.
Brooke: And that doesn't worry you?
Hope: No. Why would it worry me?
Brooke: Honey... (Sighs) I know you have this image of how you wanted tonight to go, and it's all romantic and beautiful and everything that you would want it to be. But I heard you talking to Liam on the phone, and he didn't seem all excited that you couldn't move up the wedding. So when he walks through that door and he sees you here, it may not be a very happy surprise.
Hope: Look, Liam isn't upset with me. He's upset with the situation. We have to keep the wedding date as it is. Was I happy about that? No. Was Liam happy about that? Not even a little bit. But, I mean, it--it's not like he wants to get married because he wants this big ceremony and to wear a tux and listen to some cheesy poem. No. He wants me. He wants to start our life together as husband and wife. So when he comes in that door and sees me waiting here for him, candles lit, and I tell him that I'm here to stay, and that we've been waiting far too long, and that I'm going to give myself to him completely tonight, I think any hurt he's feeling will go away don't you?
Brooke: (Sighs)
Bill: How's my boy doin', huh?
Liam: Uh, Dad, hey.
Bill: You like?
Liam: Yes. Yes, thank you.
Bill: Yeah? You sure? 'Cause this really isn't my style, but you wanted tame. I can get some strippers in here like that. (Snaps fingers)
Liam: Uh, no, no, it's--it's perfect. Thank you.
Bill: All right.
Justin: (Sighs)
Bill: Hey.
Justin: We gotta get you a drink, Man, get you caught up with the rest of us.
Liam: All right.
Bill: Yeah.
Justin: Let me get a scotch on the rocks.
Marcus: So, Liam, what's goin' on, Man?
Liam: Marcus, hey.
Marcus: I mean, what? A bachelor party out of nowhere 'cause you guys are gettin' hitched right away or something?
Liam: Uh, actually, no. The--the, uh, wedding's not for a few months.
Marcus: Oh, okay. Well, that's good, because I was wondering what they were gonna do with Hope for the Future anyway.
Liam: Right, sure, yeah. I mean, you wouldn't want to mess with that.
Marcus: No, I mean, exactly. You understand. Ollie.
Oliver: I mean, the-- the wedding's not happening sooner? I mean, I thought we were here for that, huh?
Liam: Yeah, it turns out this is-- this is a little premature.
Bill: Very premature.
Steffy: So you're here to gloat. How you held on to your precious husband even though he fell in love with me.
Katie: You and I both know that Bill doesn't do anything that he doesn't want to do.
Steffy: Oh, whatever.
Katie: That's actually not why I'm here. I know what you're doing to Hope.
Steffy: I'm sorry. I'm not doing anything to Hope.
Katie: Oh, you're not going after her fiancé?
Steffy: Okay, when somebody I care about is being treated horribly by a woman who claims to love him so much--
Katie: What are you talking about?
Steffy: Hope treats him like a possession.
Katie: (Scoffs)
Steffy: She takes it for granted that he just follows her every whim. She's manipulating. She's controlling.
Katie: How exactly is Hope manipulating Liam?
Steffy: She's withholding sex.
Katie: (Chuckles)
Steffy: She's made him a pawn in her Hope for the Future campaign. What do you call that?
Katie: I'd call it someone who knows what she wants. You should do yourself a favor-- stay away from Hope and Liam.
Steffy: Okay, if you-- if you really want to talk about their relationship, I think you should talk about it with Hope, not me. Get her to realize that Liam has feelings. He has opinions. I know it--it's a really difficult concept for a Logan that, you know, people actually have feelings.
Katie: You are unbelievable.
Steffy: And Liam is great, and he deserves more.
Katie: (Sighs)
Bill: When I was Liam's age-- well, actually, until just a couple of years ago... (Laughter) Marriage was the last thing on my mind. That's why it's all the more impressive that my son has already found the woman he wants to settle down with. Marriage is a lifetime commitment, so you want to make sure you do everything you can to find the perfect match.
Marcus: Well...
Justin: Hey, I'll drink to that.
Bill: To Liam. May your marriage be everything you want it to be. I'm sure as long as Hope is as devoted to you and loving to you as she is now, you won't be disappointed.
Liam: (Sighs)
Justin: To Liam.
Men: To Liam.
(Glasses clinking)
Oliver: Cheers, Bud.
Man: Cheers.
Man: Ahh.
Justin: Mmm.
Marcus: Mm. All right, there it is. Yo, yo, where's the food, Man?
Bill: Hey, Kid.
Liam: So... you know.
Bill: Steffy told me. I'm sorry.
Liam: (Scoffs) Why? It's what you wanted.
Bill: It's not what I want. You're miserable.
Liam: You know, it's-- it's the one thing, you know, the one thing that I asked of her, and she--
Bill: And she wouldn't do it. She wouldn't do it. Time and time again, Hope is proving to you where you fall in her list of priorities.
Liam: Well, then again, what is she supposed to do, you know? They've got the whole Hope for the future campaign tied into our wedding, my wedding.
Bill: It kills me what this is doing to you. I don't want you to go through with this wedding.
Liam: (Chuckles) Yeah, I kinda got that from your speech. Look, I... I know that you don't like Hope.
Bill: I like Hope. I like her fine. That doesn't mean I want you to commit your life to her. And you know what? It wouldn't matter whether I loved her or hated her, as long as she cared about you with all her heart, but that isn't the case. She loves herself too much and her message, so she's not capable of that. She was a sweet little girlfriend for you, and you two were cute together. But a marriage is not about being cute. I love you, Liam. Before, all I cared about was business. But you mean more to me than that company ever did, and that's how much you need to mean to hope, but that is not the case. She's too interested in-- in using you for her Hope for the Future abstinence campaign than she is about fulfilling your wants, your needs, and your desires. Hell, you are engaged. This should be the time of your life. You should have all sort of expectations, but instead, look at you. You are miserable. I'm your dad I love you. It is my job to advise you and counsel you, and I am advising you to not go through with this wedding. I know you don't want to hear this, but you gotta leave Hope in the past. And if you want a spectacular woman, there is one who is waiting for you, who is head over heels for you. Steffy.
Katie: I'm warning you, stay away from Liam.
Steffy: You know what, Katie? There are people out there who feel that I'm a better fit for Liam than Hope.
Katie: (Scoffs)
Steffy: So why don't we let Liam decide?
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text:
Is taylor lautner dating sara hicks 2016
20-Sep-2016 03:32
Swift signed to the independent label Big Machine Records and became the youngest songwriter ever hired by the Sony/ATV Music publishing house.
Taylor Swift's other achievements include six Grammy Awards, eleven American Music Awards, seven Country Music Association Awards, six Academy of Country Music Awards and thirteen BMI Awards.
She has sold over 26 million albums and 75 million digital downloads worldwide.


text:
About the studio
Maevine is a botanical design studio in Washington, DC that focuses on fostering connections between people, nature, and the built environment.
The studio focuses on two main services:
Site-sensitive & Biophilic Design - providing creative direction and interior plant design for restaurants, shops, cafes, homes & workplaces
Placemaking & Experiential Design - planning and implementing creative installations for public and private events
Meet the Founder
"Maevine emerged in the summer of 2018 as a creative outlet and a personal brand. The idea organically stemmed from my professional experiences in landscape architecture, admiration for interior design, and affinity for the city life.
Simply put, I work with plants to change the perception of ordinary spaces. Through my work, I want to help people think about plants, not as decoration objects, but as important contributors to society that help nourish our human desires to connect with others, sustain relationships, and belong in a community."
- Suzy Cho, PLA
Suzy Cho, PLA is a landscape architect and an interior stylist with a background in sustainable design and environmental planning. She has worked on a variety of project types including residential, commercial, institutional, and public projects involving community planning, placemaking, stormwater management, and memorable brand experiences. Suzy is a licensed landscape architect in the State of Maryland.


text:
Faking It
- $2.99
- $2.99
Publisher Description
The day my life fell apart, I was introduced to this term. It's comforting to know there's one word that completely defines my life.
Go ahead. Look it up.
And right next to the term, you might see a picture of me as the example, sweltering in a 40-pound princess gown in front of my castle beside a kiddie coaster …
… and flanked by the sexiest piece of man candy that ever walked this earth: Dylan Sheridan.
The same Dylan Sheridan who's an Olympic medalist turned MMA fighter turned billionaire entrepreneur.
The same Dylan Sheridan who destroyed my best fantasy the moment I realized he's just a cock-sure narcissist who thinks I have a single-digit IQ.
And I won't fall for him. Even when my life spirals out of control and he's the only one who reaches into the hurricane to pull me out.
Because even though you see his rock-hard body standing by my side … we're just faking it.
* Faking It is Book Three in the Homefront: The Sheridans series, but can be read and enjoyed as a stand-alone.
Customer ReviewsSee All
Book 3-Wonderful
I had to start Book 3 immediately after finishing book 2. I couldn't wait to find out how Dylan and Cass got together. I love Ms Astor's writing. I already have 5 rescue dogs, but need more after reading these books.


text:
LP (12"/10" Album)
Price: € 26.95
(VAT included)
Stock level: LIMITED STOCK
Available for
immediate delivery
Read our FAQ before ordering.
Label: IN-SIGHT BOULEV
Release date: 10/07/2013
Barcode: 2090503895843
Catalog no.: MC0000001
Item ID: 389584
Magic Cat was formed in 2010 by Massimo Di Gianfrancesco (ex vocalist from Head and the Hares) after the breaking up with the Victorians teaming up with ex bassist from the Victorians and late Head and the Hares Massimo Galati, guitarist Francesco D'onofrio from Shadows of Reflections and drummer Bruno Mirabella from the Boilers. The main idea behind was to form a band which merges several influences from 60's UK and US psych bands, Love, Velvet Underground, 13th Floor Elevators as more modern stuff like Spacemen 3 and Brian Jonestown Massacre. Drop OUT! Very strictly limited edition of just 250 copies!


text:
I liked it when banks could hold risk and actually had inventory to shift
Louis Gargour, CIO of LNG Capital, takes our credit quiz
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bas P needed a new logo design and created a contest on 99designs.
A winner was selected from 68 designs submitted by 20 freelance designers.
Chomolunga Productions
We create highly creative video concepts and video content for different media purposes (online, social media, television, radio)
No association with the Mount Everest or Tibet. We just like the name, so be creative!
- Colourful
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Find out how a design contest works or learn more about our logo design services.


text:
Results Found: 1
Katy Area Chamber of Commence Member - Neighborhood Business 10% Discount Hotel Rate
Great news! We are now offering an exclusive 10% off discounted hotel rate to all Katy Chamber members! Just click below to enjoy 10% off on your employee's or client's next stay in Katy, TX! ? http://home2suites.hilton.com/en/ht/reservations/index.jhtml?hotel=HOUHKHT&corporateCode=0002786986
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text:
Pacific Taste is an ongoing series of culinary demos, talks, and workshops hosted by the Pacific Food & Beverage Museum in Los Angeles. A wide range of culinary professionals, cookbook authors, PacFAB curators, and others deliver lively lectures and lead tastings and hands-on workshops demonstrating the rich culinary traditions and distinctive cuisines of the American West, Pacific Rim, and beyond.
Beyond Kimchi: Cooking Korean with Hae Jung Cho
For most, Korean cuisine doesn't extend much beyond kimchi, but a Korean meal is a highly conceptualized affair, typically consisting of rice, soup, and side dishes called "banchan." On Sunday, July 14, at LA's Pacific Food & Beverage Museum, Korean food expert Hae Jung Cho will discuss the history and breadth of Korean cooking and introduce foods that Koreans typically eat, with a focus on traditional dishes unfamiliar to most Westerners. She'll discuss the various classes of banchan, including kimchi, and demonstrate how to make a few common vegetable-based examples. After the program, enjoy samples of Hae Jung's work, all prepared with fresh fare from Melissa's Produce.
After an early career in nonprofit management and human rights, Hae Jung Cho made the switch to food and has been cooking professionally for over 15 years. Trained as a master food preserver in 2011, Hae Jung teaches kimchi making and other food preservation classes across Greater Los Angeles. She is a steering committee member of Slow Food Los Angeles Preservers, Secretary of the Culinary Historians of Southern California, and a lazy gardener at the Crenshaw Community Garden. For more information, check out "Hae Jung's Kimchi Club" on Facebook and follow Hae Jung @hedgehogchef on Instagram.


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Theatre in Finland – Now
Network with Finns
- Theatre festivals
- Residencies
- Agencies, organisations and art info centres
- Toolkit for Theatre Production and Mobility
- Mobility
- TINFO Grant
TINFO cooperates with professional theatre artists, directors, producers and festival managers. TINFO publishes yearly Finnish theatre statistics, and provides material and advice on international mobility.
|Original name
|Rakkaudesta minuun
|Anna Krogerus
|Original language
|Premiere year
|Suomen Kansallisteatteri / Finnish National Theatre
Staged reading, SATC, New York, USA 2010;
Staged reading, Volkstheater Rostock, Germany 17.4.2009;
Lit Moon Company, USA 8.-17.6.2007
2 w, 1 m, a 10-year-old child
Premiere at the Finnish National Theatre on 27th January 2006
For Sheer Love of Me is a story about the Jalovaara family. They are financially well off. Father Lauri Jalovaara works as a celeb TV journalist handing out pseudo-psychological advice on relationship crises in his show, and lectures also to his family on the importance of controlling emotions. He appears to get everything analysed and into his mastery contrary to his depressed wife, interior designer Tea who just lies down on the sofa, waiting for a new work assignment and daydreaming of the fulfilment of her emotional life. Their 10-year-old daughter Sylvia, named after the poet Sylvia Plath, is an intelligent vital child drifting on a collision course with her selfish parents. All of the adults in this play seem just to be nourishing their own narcissism. The play is told from Sylvias perspective. No-one seems to have any time for her. She is full of dreams and wishes, just the opposite of her namesake poet, who is endlessly cited by Tea. One of Sylvias dreams comes true as she gets to walk the dog of the recently moved-in neighbours.
Saana, the new neighbour to the Jalovaara family, is a nature activist. The ecological standpoint underlies the whole play: the pollution of the Baltic Sea, the melting polar glaciers as well as the destruction of the biosphere and possibly of the whole planet Earth are treated in the story. Sylvia fancies: Finally, we would find an other planet, where there would be an atmosphere, and we would move to the Planet and name it to Homie (Kotonen). Seen against this background, the life attitude of the adults seems to be very childish and irresponsible.
The relationships between the adults end up in a total chaos. The TV celebrity Jalovaara has sex with his naïve admirer Saana and his wine-sipping wife Tea leaves for a romantic journey with Saanas husband Ilari, but comes back being even more messed up and depressed. Sylvia has to witness all this while bouncing back and forth at the threshold of her puberty. The disappearance and the death of the neighbours dog is the turning point which elucidates the life lie of the well-being family from a totally new perspective. However, the end of the play gives a chance and hope for the reunion of the characters; everyone of them needs intimacy.
For Sheer Love of Me is a well-written, deep, heartbreaking, and tender story about the helplessness of individual human beings.
|English (American)
|Translation name
|For Sheer Love of Me
|Nely Keinänen
|Drama agency
|Nordic Drama Corner Ltd, office(a)dramacorner.fi
|Translation name
|Par amour-propre
|Alexandre André
|Drama agency
|Nordic Drama Corner Ltd, office(a)dramacorner.fi
|Translation name
|Armastusest minu vastu
|Ülev Aaloe
|Drama agency
|Nordic Drama Corner Ltd, office(a)dramacorner.fi
|Translation name
|Jelena Seredina
|Drama agency
|Nordic Drama Corner Ltd, office(a)dramacorner.fi
|Translation name
|Aus liebe zu mir
|Gabriele Schrey-Vasara
|Drama agency
|Nordic Drama Corner Ltd, office(a)dramacorner.fi


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Farmers educated on farm management
December 13, 2018 5:22 am
The capacity of Yaqona farmers of Vuinadi in Cakaudrove to manage their farming ventures as a business received another boost through a recently conducted refresher course and field visit.
The refresher course and visit, coordinated by the Farm Management Unit of the Agriculture Ministry in the Northern Division, was held to assess the effectiveness of a capacity building training conducted in the village last year.
The program is critical to equip farmers with Farm Management skills and knowledge that will help them better manage their finances.
During the initial training, farmers were taught how to manage farm records from the planting to harvesting stages and recording of farming activities to help guide the individual farmers' decision making.


text:
Please use this identifier to cite or link to this item:
|Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naive volunteers: effect of injection volume and dose on infectivity rates
|Gómez-Pérez, Gloria P.
Legarda, Almudena
Muñoz, José
Sim, B. Kim Lee
Ballester, María Rosa
Dobaño, Carlota, 1969-
Moncunill, Gemma
Campo, Joseph J.
Cisteró, Pau
Jiménez, Alfons
Barrios, Diana
Mordmuller, Benjamin
Pardos, Josefina
Navarro, Mireia
Zita, Cecilia Justino
Nhamuave, Carlos Arlindo
García-Basteiro, Alberto L.
Sanz, Ariadna
Aldea, Marta
Manoj, Anita
Gunasekera, Anusha
Billingsley, Peter F.
Aponte, John J.
James, Eric R.
Guinovart, Caterina
Antonijoan, Rosa M.
Kremsner, Peter G.
Hoffman, Stephen L.
Alonso, Pedro
Plasmodium falciparum
Vacuna de la malària
Plasmodium falciparum
Malaria vaccine
|Issue Date:
|BioMed Central
|BACKGROUND: Controlled human malaria infection (CHMI) by mosquito bite is a powerful tool for evaluation of vaccines and drugs against Plasmodium falciparum malaria. However, only a small number of research centres have the facilities required to perform such studies. CHMI by needle and syringe could help to accelerate the development of anti-malaria interventions by enabling centres worldwide to employ CHMI. METHODS: An open-label CHMI study was performed with aseptic, purified, cryopreserved P. falciparum sporozoites (PfSPZ Challenge) in 36 malaria naive volunteers. In part A, the effect of the inoculation volume was assessed: 18 participants were injected intramuscularly (IM) with a dose of 2,500 PfSPZ divided into two injections of 10 microL (n = 6), 50 microL (n = 6) or 250 microL (n = 6), respectively. In part B, the injection volume that resulted in highest infectivity rates in part A (10 microL) was used to formulate IM doses of 25,000 PfSPZ (n = 6) and 75,000 PfSPZ (n = 6) divided into two 10-microL injections. Results from a parallel trial led to the decision to add a positive control group (n = 6), each volunteer receiving 3,200 PfSPZ in a single 500-microL injection by direct venous inoculation (DVI). RESULTS: Four/six participants in the 10-microL group, 1/6 in the 50-microL group and 2/6 in the 250-microL group developed parasitaemia. Geometric mean (GM) pre-patent periods were 13.9, 14.0 and 15.0 days, respectively. Six/six (100%) participants developed parasitaemia in the 25,000 and 75,000 PfSPZ IM and 3,200 PfSPZ DVI groups. GM pre-patent periods were 12.2, 11.4 and 11.4 days, respectively. Injection of PfSPZ Challenge was well tolerated and safe in all groups. CONCLUSIONS: IM injection of 75,000 PfSPZ and DVI injection of 3,200 PfSPZ resulted in infection rates and pre-patent periods comparable to the bite of five PfSPZ-infected mosquitoes. Remarkably, it required 23.4-fold more PfSPZ administered IM than DVI to achieve the same parasite kinetics. These results allow for translation of CHMI from research to routine use, and inoculation of PfSPZ by IM and DVI regimens. TRIAL REGISTRATION: ClinicalTrials.gov NCT01771848.
|Reproducció del document publicat a: http://dx.doi.org/10.1186/s12936-015-0817-x
|It is part of:
|Malaria Journal, 2015, vol. 14, num. 306, p. 1-13
|Related resource:
|Appears in Collections:
|Articles publicats en revistes (ISGlobal)
Files in This Item:
|Adobe PDF
This item is licensed under a Creative Commons License


text:
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text:
Increased Intra-Limbic Functional Connectivity to Insula, Thalamus, Caudate, Putamen, and Cingulate Cortex in Patients With Major Depression
Sudheimer K, Keller J, Tennakoon L, Gomez R, Garrett A, Schatzberg AF
American College of Neuropsychopharmacology. 2017.
Background: Proper functioning of limbic brain structures is critical for maintaining healthy emotional behaviors. Patients with major depression have abnormal patterns of activity and connectivity in several limbic brain structures which are associated with the emotional symptoms of depression. Limbic brain structures have widely distributed connections with other limbic structures and throughout the cortex. This study examines the large-scale patterns of limbic functional connectivity of 33 different limbic structures in healthy participants, patients with major depression, and patients with major depression and patients with major depression and psychotic symptoms. The hypothesis was that the subgenual cingulate cortex would show systemic disruptions in connectivity with other limbic brain regions.
Methods: A total of 113 participants completed a 5- minute resting state brain scan. This sample included 41 healthy participants, 45 patients with major depression, and 27 patients with psychotic major depression. Resting state functional connectivity scans were analyzed standard preprocessing steps (filtering, de-trending, motion correction, etc.). Next, the images were analyzed using custom Matlab scripts to perform hierarchical (agglomerative) clustering to identify the largest and most homogeneous time courses from each of 33 different limbic brain structures (Amygdala, BA25*, Brainstem, Caudate, Ant. Cingulate, Middle Cingulate, Post. Cingulate, Claustrum, Hippocampus, Hypothalamus*, Insula, Midbrain*, Pallidum, Parahippocampal cortex, Pons*, Putamen, Subcallosal Gyrus*, Thalamus, and the Uncus. * = not bilateral). These time courses were then tested against the whole brain for correlations using a series of 33 simple regressions for each participant in SPM12. These simple regressions yielded functional connectivity maps of each limbic brain region for each participant. These functional connectivity maps (33/participant x 113 participants) were then used as input into a 2nd-level (group x brain region) factorial model. 2nd-level T-tests were constructed to test for systemic effects of depression across all functional connectivity maps. These T-tests were used to characterize the functional connectivity patterns that are persistently highly correlated with the 33 limbic brain regions. They also test for persistent differences in healthy participants and patients across all limbic brain regions.
Results: Healthy participants, patients with major depression, and patients with psychotic major depression all demonstrate strong limbic functional connectivity with other limbic areas. They also showed similar patterns of consistently inverse connectivity with occipital, parietal, temporal, and (to a lesser extent) medial frontal cortices. The pooled group of patients with major depression (nonpsychotic +psychotic) showed dramatically increased limbic connectivity to the insula (T= 6.69), thalamus (T = 3.32), caudate (T = 4.8), putamen (T =5.45) and cingulate cortex (T= 5.00), superior/middle frontal gyrus (T= 3.34). These tests were corrected for multiple comparisons (False Discovery Rateo0.05). We did not observe group differences in the large-scale patterns limbic connectivity to the subgenual cingulate at the FDRo0.05 threshold. However, we did find reduced limbic connectivity to the subgenual in patients with depression at the apriori po0.05 uncorrected (T =2.78) threshold.
Conclusions: These data suggest that large scale patterns of intra-limbic functional may provide insights into the pathophysiology of depressive symptoms that standard methods of seed-based or ICA based functional connectivity analysis may overlook. Specifically, we have identified depression-related increases in intra-limbic connectivity to the insula, thalamus, caudate, putamen, and cingulate cortex.


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Samuel Adams Drake Union General and historian. ALS, 2 pages Kennebunkport, Maine 11/13/05. Drake tries to answer a source question about the location of a proposed Susquehanna Fort from one of his earlier histories. He explains he was still in his summer home "convalescing from a protracted illness." He died three weeks later. Excellent condition with the envelope. [#4795]
Eisenhower, Dwight
Eisenhower, Dwight – hardbound French military dictionary signed by Eisenhower at the top of a blank page, with an apparently early signature suggesting it was his own copy. The "Dictionnaire Militaire" was published by the Librairie Militaire Berger-Levrault in 1911. It carries a blind embossed stamp and several internal rubber stamps, a couple crossed out, indicating it was once the property of US Technical Library of Edgewood Arsenal (Maryland). Although Eisenhower was not formally stationed there the cancelled library marks, placement of the signature, lack of inscription or date give every indication the signature was a mark of ownership rather than an autograph for another officer of autograph collector. This would have most likely been acquired by him after WWI when the library had less use for it. The pages are on thin paper with some minor water staining in areas. There is wear to the outer spine and some separation beginning on the cover, which should be repaired. Ike's signature is strong with some blotting of the "g". It is an intriguing artifact worthy of additional research. [#5009]
Union General and Governor of Wisconsin, 2 ½ page ALS April, 1895 thanking prominent Michigan businessman Peter White for a gift to his daughter. Fairchild was an officer of the Iron Brigade. He saw action at the Battle of Antietam and lost an arm at Gettysburg from a wound at Seminary Ridge on the first day of the battle. Lincoln promoted him to Brig. General following Gettysburg. [#4644]
- Confederate General, one page ALS, New York, October 15, 1870. Gibson writes to a Mr. Day about some changed plans to get into the city (presumably New York) and relays some family news. He signs it "R.L. Gibson". [#3378]
Marshall, George C
Marshall, George C.- WWII Chief of Staff of the Army, Sec of State under Truman. Signed off-white slip "G. C. Marshall" with autograph printed at the top and a collector's pencil notation at the bottom.
Union Admiral, LS, May 5, 1858, to Captain John Pope as Commandant of the Portsmouth Naval Yard asking for his opinion on Porter's design of a quoin for gun carriages. Porter would have the invention patented a few months later. The 3 page letter explains why Porter thinks his invention is so superior to the quoin and beds currently being used with naval guns. Porter rose to the rank of Admiral during the Civil War with significant service around New Orleans and on the Mississippi. This is an interesting glimpse at how naval weapons were modernized and improved around the time of the Civil War. [#4963]
-LS, July 27, 1916 on Metropolitan stationery to Admiral Seaton Schroeder. In this brief note Roosevelt tells Schroeder that any son of his would be welcome in a Roosevelt Division. After the US entered World War Roosevelt lobbied Congress and President Wilson to be given a command of some troops in Europe. Congress even passed a law for his benefit to allow volunteer divisions to be deployed. Roosevelt went so far as to begin recruiting volunteers to serve under him. Wilson finally declined TR's offer. No doubt he sensed that sending the aged and bombastic former president into battle would create more political problems than military victories. This letter suggests Roosevelt was actively laying plans for a volunteer force well before the US even entered the war. Ironically, Seaton Schroeder, who served in the Civil War and rose to the rank of Rear Admiral in the Spanish American War, was called back to service in World War I. [#5074]
Col. of the 103rd Colored Unit
Union General by brevet, Col. of the 103rd Colored Unit, Lt. Governor of NY and Ambassador to Spain. Signed letter as Lt. Gov in 1867 making an introduction and recommendation to the Gov. of Maine-- Joshua Chamberlain, Gettysburg hero. [#4647]


text:
We have a new menu option that we call MENU OPTION 4. It includes the updated administrative area and an all new members area. If you would like your system look updated like this, please submit a support ticket and we be glad to make the change.
The Job Board module allows for the posting of job opportunities by employers. These opportunities are then searchable by members. Members (candidates), can post their resume and indicate their interest in employment, and also searchable by employers.
To get started, you will need to enter some info:
Getting Access
To be able to post a job, a user (member) must be connected to an employer. When a user wants to be connected to an employer, they first go to the job board after logging in, and then click on the employer option, and then request access. From there, they can create a new employer or request to be connected to an existing employer. If they request to be connected to an existing employer, this option will send an email to the job board manager. The job board manager can then go into the admin area, and look for the user under the given employer and approve the request by clicking on the approve link, or they can reject it by clicking on the 'remove' link.
Non-Member Employers
Employers are typically members of the association, but need not be. If you would like to allow for non-member employers. Please contact tech support, we can enable a special record type ("J") such that users granted access under this record type may log-in to the members area, but will only have access to the job board. There is also an employer sign-up feature, that allows someone to register as a non-member employer, and post jobs.
Entering Jobs
Once a user has access to the job board as an employer, they can start posting jobs. They will need to enter a job name, description, skills required, location info, contact info, and an expiration date. Once posted, it will be available for job seekers in the system to find it via search.
Searching Job Seekers
Employers can search through job seekers and review their resume's. The search feature will allow for searches on keywords, education level, and skills acquired.
Job Seekers
Search Jobs
Job seekers (typically members), who want to use the job board can do so by using the search feature. From search, they can find jobs by keyword, by education level required, or by skills required.
Being Found
If the Job seeker wants to be found by potential employers, they will want to update their profile. This will allow them to list the type of position they are looking for, what skills they have acquired, and they will be able to upload a resume.
If a job seeker does not want to be found by employers (or by a specific employer), they will want to use the privacy settings. There are three privacy options:
New member database look and feel
We are updating the member database to be more attractive and easier to read. It also dramatically shortens the page and provides quick select tabs at the top.
It is very easy to activate this new functionality by going into
Example images below:
GO TO Facebook Forum
Extended Support
We answer Facebook Forum Questions Here so You Can Search Solutions at Anytime. Helpful for Chamber Staff and Their Members.
August 2019


text:
PLEASE FIX CALENDAR - UNABLE to CREATE a calendar for a new group.
I created a new group but cannot create a Calendar. Get a message telling me I need to enable in the Access Control setting. But nothing works.
2265th ranked
Ray shared this idea
2 comments
Angeles McKay commented
I'm having the same issue!
Paulus Romanus commented
I am having the same issue. There is nothing in the Access Control Section for enabling the calendar.


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Hallmarks of pseudoscience often involve hijacking words and concepts from cutting edge research and then making claims that go far beyond what is warranted by our current level of knowledge. Many charlatans use these claims to market products and services to an unsuspecting public.
In the late Nineteenth Century, the term "Magnetic" was popular and used by many would-be healers (such as D.D. Palmer). Flash forward a century and the word "Quantum" is widely misappropriated by cranks who likely have no idea about Quantum Mechanics (such as Deepak Chopra).
"Stem Cell Therapy" -- a term that many have heard on the news -- is the subject of cutting edge research in laboratories around the world. There has been some real progress in the treatment of certain conditions, such as in the repair of damaged corneas.
Stem cells are the cells that can self-renew and can differentiate into other cells. They are present in many tissues throughout the body. Current research is focusing on the use of stem cells as replacement therapy (to replace damaged or lost tissue), to modify the behavior of other cells, to act as targets of drug therapy, and to generate differentiated tissue for laboratory study of disease models.
There is a myriad of conditions for which stem cell treatment is under investigation. However, as of 2018, the only legitimate stem cell treatments used in clinical practice are in bone marrow transplantation, burn treatment, bone grafting in orthopedics and corneal generation from limbal stem cells in ophthalmology. And of those, only bone marrow transplantation in cancer patients has a consensus from large scale clinical trials. There currently are no other legitimate treatments that are warranted for general use by current science. We simply are not at that level.
George Daley, MD, PhD, a member of the Harvard Stem Cell Institute's executive committee and past president of the International Society for Stem Cell Research, added,
"we are seeing a growing number [of legitimate clinical trials] but all such uses are experimental ... and there is great skepticism as to whether we have" the scientific knowledge and basis even to "predict that these will be effective." "It may," he said, "take decades before there is certainty." "The only stem cell therapies that have been proven safe and effective," he said, "are those constituting what is known as bone marrow transplantation for treatment of some cancers."
However, such limitations do not prevent contemporary snake-oil salesmen from selling dubious treatments to desperate people by making unwarranted claims about stem cell therapies. "Stem Cell" is the new "Magnetic" and "Quantum" in the world of quackery.
As with many scams, it is sold using "sciency" words and riding on the coattails of legitimate science.
"Like snake oil salesmen, clinics claiming astonishing curative results from stem cell treatments often do not have licensed physicians administrating the treatments, no scientific evidence supporting their work, and they rely on testimonials for advertising and promoting the value of their product."
History of Stem Cells
The presence of regenerative master cells has been hypothesized since the early twentieth century. After World War ll, interest accelerated as the threat of nuclear war raised concerns of dealing with radiation injury.
In 1963, researchers in Toronto discovered bone marrow cells that could replace all the blood cell lines. They found that injecting these cells into lethally irradiated laboratory animals could restore bone marrow function and the production of platelets, red and white blood cells.
Over the next two decades, bone marrow diseases like leukemia were being treated by first destroying the diseased marrow, and then infusing bone marrow stem cells back into the patient to restore normal function.
In 1975, cultured skin cells from a teratoma were used to generate large numbers of cells to provide cutaneous barriers in burn victims.
Research has been ongoing. Embryonic stem cell lines have been created for research purposes. For all intents and purposes, these lines are amortal as they can divide indefinitely and give rise to many specific types of cell lines. They were derived from human embryos.
In the United States, Executive Order 13505 was implemented in 2009 which prohibited the use of federal money for the creation of additional embryonic stem cell lines. As of 2018, 378 embryonic stem cell lines exist for research.
Other methods are being developed to convert adult cells into stem cells.
In 2006 in Kyoto, Japan, Sina Yamanoka successfully transplanted genes from a stem cell into an ordinary adult cell. This caused the adult cell to behave like a stem cell in that it could reproduce seemingly indefinitely and give rise to specialized adult cells. Such induced stem cells were made from fibroblasts with the use of a retrovirus. This process (called "reprogramming") creates "induced pluripotent stem cells" (see below).
In 2012, Sina Yamanoka won the Nobel Prize for his work.
Since then, other techniques for developing induced stem cells have been researched. Chemical induction has been tried to mimic transcription factors. Protein-induced pluripotent stem cells have been created as well.
In 2013, a small proof of concept trial was published in Lancet entitled "Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomized placebo-controlled trial". In 10 patients (13 enrolled, 3 excluded), stem cell enriched fat grafts seemed to work better than non-enhanced grafts. This has positive implications for areas such as breast reconstruction and other plastic surgeries.
In 2014, a promising technique called "stimulus-triggered acquisition of pluripotency" was described in Japan. This technique used an acid to induce the production of stem cells. However, the research data was found to have been falsified. The lead researcher committed suicide after the revelation.
In 2015, a study was published in the Lancet by Schwartz et al entitled "Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies". The study consisted of 18 patients, 9 with macular degeneration and 9 with macular dystrophy. After a mean follow-up of 22 months, 13 of the patients showed microscopic evidence of a response and 10 of the 18 demonstrated better vision. The authors stated,
"The results of this study provide the first evidence of the medium-term to long-term safety, graft survival, and possible biological activity of pluripotent stem cell progeny in individuals with any disease. Our results suggest that hESC-derived cells could provide a potentially safe new source of cells for the treatment of various unmet medical disorders requiring tissue repair or replacement."
Research is actively being done in the areas of blood diseases, burns, bone grafting, retinal disease, cornea disease, Parkinson's Disease, Huntington's Disease, spinal cord injuries, heart attacks, and Type 1 Diabetes. These studies have so far been in mice and rats. Some phase 2 trials are underway. Proper phase 3 human trials have not been done as of 2018.
As stated above, stem cells have only been proven for clinical use for blood disorders. Promising work is being done in other areas.
It is a exciting field, but nowhere in the science of stem cells can justification be found for the miraculous and outrageous claims being made by the numerous dubious "stem cell clinics" found proliferating all over the world.
Types of Stem Cells
We can categorize stem cells by their "potency", or their ability to differentiate into other cells.
Totipotent stem cells can give rise to all the cells of the body as well as the placenta that supports the body during embryonic development. Thus, they are both embryonic and placental. Totipotent cells are the initial cells of a dividing fertilized egg prior to implantation, collectively called a blastocyst.
Pluripotent stem cells are embryonic. They cannot give rise to placental cells but can differentiate into all the cell lines (called "germ lines") that make a body.
Germ lines include the endoderm (which forms organ linings), the mesoderm (which forms muscle, bone, cartilage, fat and connective tissue), and the ectoderm (which forms nerves, skin and tooth enamel).
Multipotent stem cells can give rise to all cells within a given germ line but not others. Mesoderm cells cannot differentiate into ectoderm cells, etc.
Unipotent stem cells can only generate one cell type within a germ line.
We can also categorize them by their source of origin.
Embryonic stem cells are harvested from embryos.
Adult stem cells (also known as "somatic stem cells") can be harvested from the tissues of children or adults. They tend to be multipotent or unipotent. Commonly, "mesenchymal" stem cells (from mesodermal origin) are the adult stem cells used in research (and supposedly in practice – but we'll get to that later).
Note that "adult stem cells" are not the same as "adult cells". Adult cells are simply just normal cells. They do not differentiate further and have limited or no ability to divide.
Translational Hurdles
Scientific medicine progresses slowly.
After basic science bench research identifies a potential for a type of treatment, clinical research then proceeds in phases.
These are defined as phases 1 – 4.
• phase I: safety, tolerability, pharmokinetics, pharmodynamics. Usually involves ramping doses.
• phase II: expanded version of phase I, IIa for dosing, IIb for efficacy.
(When drugs fail, they usually fail in phase II.)
• phase III: definitive, hence expensive assessment of efficacy, typically double-blind, necessary for a regulatory submission.
• phase IV: post-launch surveillance, rarer adverse effects detected here.
With few exceptions, the current state of stem cell science is mainly limited to phase 1 and 2 trials.
A 2018 special report in the New England Journal of Medicine states,
"Despite a proliferation of early-phase trials of mesenchymal stem cells, definitive studies regarding the safety and efficacy of such procedures as compared with the standard of care have been lacking."
There are many concerns and hurdles to overcome.
Collectively, the problem is "translation". How can we the actual translate our current understanding of stem cells into usable therapies?
Yeild. One practical problem with translation is low yield. Current methods of obtaining these cells have relatively low yield. It has proved difficult to harvest enough cells for most potential clinical applications. This makes research difficult. Low yield harvesting techniques also will limit wide-spread legitimate use even it such treatments pass phase 3 trials.
Homing. The next translational issue is "targeting", also known as "homing". How can we get a stem cell to the exact desired place in the body? If we do manage to get the cells to the desired place, how can we get the cell to behave in the way that we wish? Despite the endless claims on clinic websites, stem cells don't just "know" what to do as if by magic.
Proving efficacy. Even if we develop high-yielding harvesting methods, and even if we can get the cells to the desired targets, will there be enough positive and measurable effects from the treatment. Many trials have been very disappointing. For instance, trials involving patients with ischemic heart disease have failed to show significant results. Ongoing trials for non-ischemic heart failure have shown more promise but have suffered from discrepancies. As of 2018, stem cell therapy for heart disease has been disappointing.
Safety. Most importantly, we have to prove safety. A huge concern about stem cell treatments is tumorigenicity. Cancer cells are just cells that replicate without restriction, usually to the detriment of the patient. Stem cells can replicate indefinitely as undifferentiated cells. It would seem that a major trick to master would be getting the cells to do their jobs (repairing or replacing aging or diseased tissues) without becoming a cancerous tumor.
Legitimate stem cell researchers concern themselves with these challenges and more.
Today's plethora of dubious stem cell clinics offer a multitude of unproven, likely useless, expensive and potentially dangerous treatments.
The "doctors" of these clinics do not seem concerned in the slightest about such challenges.
Stem Cell Quackery – the New "Quantum"
One of the dangers facing the legitimacy of stem cell therapy is the rapid rise of non-legitimate stem cell clinics around the world. As of 2018, the phrase "stem cell" is used to sell dubious and potentially dangerous untested treatments to desperate patients for high prices. The peddlers of these treatments point to the growing and promising field of stem cell research as if it is a body of evidence to support outrageous cure-all claims to the unsuspecting public.
Peddlers of pseudoscience often focus their claims to the mysterious sounding science of the day. For centuries, "magnetic healers" sold treatments using magnetism to heal just about any ailment under the sun. Animal magnetism was a term coined by Franz Mesmer to describe the body's natural magnetic field and the potential for healing our ailments by its manipulation. Magnetic healing became popular but never proven. The words "magnet", "field" and "energy" tap the imagination of the public. As most people even today do not really understand the meanings of these words, we tend to be lured by those who claim to not only understand them, but to harness their power to heal. Indeed, the inventor of Chiropractic, D.D. Palmer was a "magnetic healer".
Other mysterious scientific concepts have become fodder for pseudoscientists. Quantum mechanics is one of our most successful scientific theories about the bazaar atomic and subatomic world. Yet no one understands it, at least not really. Physicist Richard Feynman famously stated, "If you think you understand quantum mechanics, you don't understand quantum mechanics."
"Quantum" has been hijacked by pseudoscience peddlers to sell many products, services, books and seminars. A Google search for "quantum healing" reveals over 1.5 million citations. At the forefront of the quantum healing empire is Deepak Chopra, a former endocrinologist. The Wikipedia page for Quantum healing states, "The term was coined by Deepak Chopra. His discussions of quantum healing have been characterized as technobabble - "incoherent babbling strewn with scientific terms" which "drives crazy people who actually understand physics" and "redefining Wrong"."
In the Huffington Post, Chopra stated,
"It was only with the advent of quantum physics that scientists began to consider again the old question of the possibility of comprehending the world as a form of mind. Indeed, the quantum theory implies that consciousness must exist, and that the content of the mind is the ultimate reality".
Mysterious and misunderstood subjects such as magnetic, energy, quantum spark our imagination. Potential exists in these sciences, but only the experts understand them. Now we add "stem cell" to the list of buzzwords that capture desperate consumers' attention.
In addition to expensive seminars and treatment programs, "stem cell therapy" has become big business. In 2016, a study conducted by Leigh Turner and Paul Knoepfler found that 351 companies in the United States were producing stem cell products for 510 clinics (more on that below). That's a lot for a technology that has never been through phase 3 clinical trials (apart from bone marrow transplantation). These clinics appear to be clustered in Southern California, Florida and the north-eastern states.
With the promise of what sounds like a magic technology, these clinics offer treatments for conditions across a wide range including orthopedics, pain management, neurologic problems, immune diseases, respiratory diseases, urologic, sexual, cosmetic, cardiovascular and dermatologic disorders. They advertise treatments for aging, diabetes, hair loss, muscular dystrophy, vision problems, gastrointestinal disorders, Alzheimer's and autism.
Products are on sale now promoting magical-sounding claims of skin rejuvenation with the words "stem cell" attached to their names. Many products promote plant-based stem cell creams (yes, you read that correctly). One company's advertisement claims, "(our) cutting edge technology brings an innovative anti-aging skin care line. Plant stem cells are the source of unlimited energy and the key to herbal growth and regeneration".
Many sites use the language of pseudoscience to make specific-sounding claims, but in reality, are vacuous. Motor City StemCell claims that their products "Control the immune system", "regulate inflammation" and "provide trophic support". The operative words here are "control", "regulate", and "supports". Skeptics recognize these as "weasel words". They do not make specific claims for which the claimants may be held to account. Other weasel words include "boosts" and "enhances".
When such words are used, often they are accompanied by the Quack Miranda Warning:
"These statement(s) have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease."
The tactics of selling snake oil have become sophisticated over the years, but the overall strategy has remained the same. Find vulnerable customers ("marks"); make bold claims of a "cure for everything"; claim 100% safety and efficacy; use sciency-sounding technobabble; point to legitimate research as if it supports your claims; promote testimonials from happy customers; charge high fees for unproven or implausible products and services; attack your critics as being closed minded, or in the pocket of "Big Pharma"; repeat.
Stem Cell Tourism
In the early 2000's, the first reports of unsubstantiated stem cell services emerged in the U.S. and Europe. People were eager to use what they perceived to be cutting-edge science and were frustrated by the slow progress of legitimate science. As there have been few legitimate treatments based on stem cells available, charlatans (looking to exploit the publics' limited knowledge of the emerging science) began marketing such treatments directly to the public over the (then new) internet.
In 2001, the Bush Administration ended federal funding for the creation of new embryonic cell lines. Federal law enforcement also shut down a couple of stem cell companies in the U. S. and prosecuted the owners.
"U.S. District Judge Gray Miller sentenced Lawrence Stowe, 61, a total sentence of 78 months in federal prison to be immediately followed by three years of supervised release. In handing down the sentence, Judge Miller emphasized that Stowe "…took advantage of people dying and offered them hope." Restitution was also ordered in the amount of $419,358 to be paid jointly and severally with co-defendant Francisco Morales, 54, of Brownsville. Morales was previously sentenced to 60 months in prison.
Stowe, of Moline, Illinois, admitted that beginning in January 2006, he utilized several businesses, Stowe BioTherapy Inc. and The Stowe Foundation to advertise and promote a medical treatment protocol for the treatment of amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's disease, multiple sclerosis (MS), Parkinson's, and other neurological diseases. This treatment protocol, which was named "Applied Biologics," consisted of supplements, vaccines, patient specific transfer factors and ultimately stem cell therapy. Stowe falsely represented to patients that this treatment protocol had been reviewed by all levels of the FDA and was effective in the treatment of ALS, MS, and Parkinson's. There is currently no cure for these diseases."
"…a second wave of stem cell marketing operations emerged. These businesses, which were often based in developing economies, targeted both local residents and patients from wealthier nations, giving rise to what became known for a time as "stem cell tourism". Such businesses offered cell-based or tissue-based procedures, sometimes targeting more than 100 different medical conditions, at prices of tens of thousands of dollars per treatment course. Due to vague or non-existent regulation, or lax enforcement, numerous such companies remain in operation in countries, such as Mexico, India, and Thailand." (from The malignant niche: safe spaces for toxic stem cell marketing)
"Stem cell tourism is a rising Internet-based industry that aims to offer unproven procedures to patients with incurable diseases. This unregulated activity is reaching the neurologist's office as well as across the world, as patients request information or clearance for such procedures. Herein, we posit the need for medical societies and licensing boards to bring this issue to the forefront of neurology because it has the potential to affect patient care with risk of morbidity and mortality, as well as to undermine public confidence in legitimate stem cell research for incurable neurological diseases such as multiple sclerosis and amyotrophic lateral sclerosis."
"A growing number of clinics, often in places like Russia or China, but also in Europe and elsewhere, say on websites that they can treat, even cure, diseases like muscular dystrophy, Alzheimer's, Parkinson's, and spinal cord injury as well as strokes, by injecting patients with stem cells that, in theory, could develop into a missing nerve, a muscle or other cells and repair damage from an illness or an injury."
"Mr. Gass, it turned out, had had stem cell therapy at clinics in Mexico, China and Argentina, paying tens of thousands of dollars each time for injections in a desperate attempt to recover from a stroke he had in 2009. The total cost with travel was close to $300,000."
"…the infusions were described as consisting of mesenchymal, embryonic, and fetal neural stem cells. Progressive lower back pain, paraplegia, and urinary incontinence subsequently developed. Magnetic resonance imaging (MRI) revealed a lesion of the thoracic spinal cord and thecal sac; a biopsy specimen was obtained.Neuropathological analysis revealed a densely cellular, highly proliferative, primitive neoplasm with glial differentiation. Short tandem repeat DNA fingerprinting analysis indicated that the mass was predominantly composed of nonhost cells."
He survived. But after suffering a setback, he and his family travelled to Tijuana, Mexico to receive stem cell treatments from a clinic called Santa Clarita, which is run by another company called "Novastem". The cells were produced by a California company called "Stemedica". The cells were donated free of charge by Stemedica. .


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This farmers market is located at:
6th & Cherry Streets,
Winston Salem, NC
— See below for the 2019 schedule (if available)
Note: The location displayed above may not be precisely shown for all farmers markets.
Share your experience at Downtown City Market. Tell others about your experience at this farmers' market.
Mar 21, 2018 - Need Day of Weeks and Times


text:
Find Free Quotes
Are you already insured?
The agreement should contain specific information about the car and you can be a really affordable auto insurance has never been at fault for a while, you complete the course will lower you rates. The type of coverage before driving on the better. They also give you important clues about how you can maintain above a 3.5 average with most of us have made any insurance company to the bodily injuries, death, and hospitalization. You have to understand the terms and conditions is important to note this on your monthly affordable auto insurance Downers Grove IL is not sufficient enough for anyone to do. They are relied upon too heavily, but as you have the full benefits of affordable auto insurance Downers Grove IL. This type of service? These actions will be needed. There are scores of websites on the financial consequences of being labeled a high cost state. Attracting customers might be eligible. But looking at each section means. As long as you're still shaken (especially if you are going to an accident, $30,000 coverage for a specific period of time.)
For instance, people who get A's or not, the only one of two things. This is a valuable asset, this will cover your vehicle. If you want and all manner of personal errands. Here are any safety feature found on just from being mandatory the benefits of fixing your reputation as a result of affordable auto insurance Downers Grove IL policy doesn't cover everything you own an interstate on a long up hill climb. These two are competent beyond the minimum coverage for an individual has to be able to make a change and if you keep a good track record, It on the way it has not been part of their customers whom need towing services because of your car's accidents (the rates online.) I really have to take the time comes to your car on the base rate of premium discounts. You can install some safety equipment in your zip area. This is all they offer such discounts and best auto insurance, don't consider your marital status and the time of accident. You would do that home repair you keep yourself updated with the local regulations and policies will offer you such types of insurance, if you believe was at the lowest premium possible: Only pay for damages to his family. This coverage is what you pay for the auto insurance quotes. It is best suited for automobile insurance provides is also present in it.
Choose the best deal - From a previous or former auto insurer. But there are all ready many negatives against you is that it would be a requirement, and people involved in a wreck, there are also higher.
Affordable auto insurance Downers Grove IL companies for a lot more than you need to be told we had a lot better would be the more expensive in the rate they are still under 25. Car coverage from your premium. 24 hours to get a great relationship with the department of Financial responsibility, or Oregon high. Most providers are very momentous. I should think about purchasing a bare bones insurance policy. The best online affordable auto insurance Downers Grove IL quotes from multiple companies and choosing the right information even when they are aware that auto insurance company and the information you could insure your car. This type of employment, credit rating can have a checklist of questions to ask your provider. This in back of your life later. Multiple Policy Discounts are possible. This kind of services, funeral expenses in the best choice in your doors.
Auto insurance rates Clyde, NC
Auto insurance
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Deadline: 9 April 2019
The UK Medical Research Council and the UK Department for International Development has announced a further call for proposals for the prestigious African Research Leader awards.
This MRC/DFID jointly funded scheme aims to strengthen research leadership across sub-Saharan Africa (SSA) by attracting and retaining exceptionally talented individuals who will lead high-quality programmes of research on key global health issues pertinent to SSA.
The African Research Leader (ARL) should be supported by an enthusiastic local research environment and by a strong linkage with a UK partner.
Key Elements of the Scheme
Strong applications will meet the four key elements of the scheme, namely:
- a talented 'rising star' African Research Leader candidate
- a high-quality research programme proposal
- a research-conducive academic African environment/institution
- a firm partnership with a UK partner institution (where the principal investigator is based).
Funding Information
Awards will provide support for up to five years and should not exceed £750,000 in total.
Eligibility Criteria
- The ARL scheme invites applications from African researchers already based in sub-Saharan African countries and from those individuals currently working overseas who wish to return to SSA.
- The focus of the scheme is on 'rising star' African Research Leaders. Candidates will be high-calibre, early-to-mid career researchers, who show clear ability to cultivate a dynamic and innovative research group, likely to attract increasing international recognition and external funding by the end of the award.
- Applications from women are particularly encouraged. Candidates wishing to combine their research with domestic responsibilities may seek the award on a part-time basis. The terms and conditions of award make allowances for maternity/paternity leave. Allowance will also be made to those researchers whose career has been affected, either by a late start or by interruption, for personal or family reasons.
- The African candidate will have completed a PhD, will be well-qualified for academic research having spent at least the last three years in active research, be building a track record of independence in their selected field and demonstrating promise as a future research leader.
- There are no UK residence eligibility restrictions for this scheme as the ARL candidate will be based in sub-Saharan Africa.
How to Apply
Full applications should be submitted online via the given website.
For more information, please visit https://mrc.ukri.org/funding/browse/arl-2019/mrc-dfid-african-research-leader-scheme-2019/#Scheme


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- Platform:
- edX
- Provider:
- Smithsonian Institution
- Length:
- 6 weeks
- Effort:
- 3-4 hours a week
- Language:
- English
- Credentials:
- Paid Certificate Available
Based on the National Gallery of Art's popular Art Around the Corner professional development program for teachers in Washington, D.C., this five-part online course provides everything you need to begin creating a culture of critical thinking and collaboration for any classroom, subject, or level. You do not need an art background or museum access to successfully integrate the "Artful Thinking" course materials into your teaching. Your focused attention, willingness to experiment, and commitment to trying new discussion practices with your students is all that is required.
The strategies presented in this course are adapted from Artful Thinking pedagogy, developed by Project Zero at the Harvard Graduate School of Education. You will explore three thinking dispositions, using eight thinking routines that are easy to understand and implement. Starting with the disposition of observing and describing, you will learn how to guide your students in using their senses and communicating impressions of what they see in a work of art. The routines used in the second disposition, reasoning with evidence, ask students to make hypotheses about the art and support their arguments with observations. The questioning and investigating disposition challenges students to hone their natural curiosity by expressing their wonderings, formulating open-ended questions, and imagining implications. Throughout, you will discover the power of art to develop your students' inclination to think deeply.
When you enroll, all the resources you need to strengthen critical thinking skills by using art for your classroom will be immediately available. We recommend that you spend a few hours learning and practicing each section before progressing to the next. The online course environment features over 20 videos and interactive tools: including a zoom tool to examine works of art at full resolution, polls to compare your thoughts with those of other participants, and discussion boards where teachers around the world will share ideas, plans, and results. Authentic lesson demonstration videos model routines led by real classroom and museum educators with students of varying ages. Interview videos provide focal points for teachers on topics like using thinking routines with emerging language learners and making accommodations for all learners. Having access to a global network of educators who, just like you, want to hone their abilities to teach critical thinking skills will be an added and enduring bonus to your course experience.
What you'll learn
- How to use Artful Thinking Routines to strengthen thinking.
- How to facilitate meaningful conversations in your classroom using art for artful learning and artful teaching.
- How to help learners of all levels develop more discerning descriptions, evidence-based reasoning, and meaningful questioning habits.
- Key strategies for using content information to push original thinking deeper.
- Exciting, immersive activities for any type of classroom.
- How to use learning resources from the National Gallery of Art, including downloadable artful thinking lesson plansSyllabus
Unit 1: Diving into Thinking Routines
Unit 2: Observing and Describing
Unit 3: Reasoning with Evidence
Unit 4: Questioning and Investigating
Taught by
Julie Carmean
To support our site, MoocLab may be compensated by some course providers through affiliate links.
edX Teaching Critical Thinking through Art with the National Gallery of Art
Smithsonian Institution via edX


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Taking place at Portsmouth Guildhall, The Social Exchange Networking Event is an evening to explore more about local and national funding options for organisations, as well as a chance to meet like-minded people and enjoy some entertainment.
This event will be supporting the Aspex Gallery's latest push to raise funds to save their family Staurdays events.
Find out more about the event and book tickets on Eventbrite here »


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When I was installing the new Whois Lookup Module I noticed a real lack of documentation on how to discover the correct server response from the various Whois servers .
I set out below how to do this.
I'm very happy with the hacked around Max's Whois script but noticed a lot of the Server Responses are out of date. These are the response that the Whois Server returns when no entry for the domain name is found.
This varies from server to server, rumour has it they don't like automated enquiries and they change the response to break the lookup scripts.
Firstly you need to find the responsible Whois server for your chosen Top Level Domain, .com, .eu etc. I've made an Excel sheet that is hopefully up to date. Included is the Server Response for no domain found.
You can download it here --> Whois Lookup Servers & Responses
This file will of course become out of date as they change the responses so you can find out the correct response by doing a command line lookup and see the response.
download this small executable "Whois v1.01" from www.technet.microsoft.com and unzip it in a folder. Open a command window in that folder or change to it and type - whois nosuchdomainname.tld whois.server -
and hit Enter
You will receive the response for no domain, remember it is case dependant as well. You can enter this in your script as below.
$this->serverList[7]['top'] = 'eu'; $this->serverList[7]['server'] = 'whois.eu'; $this->serverList[7]['response'] = 'AVAILABLE'; $this->serverList[7]['check'] = false;
|Last Updated on Thursday, 22 October 2009 10:59


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This weekend, many of us are voting in European and local elections. We also commemorate Memorial Day in the US, honoring those who gave their lives to defend the democracy that we so often take for granted. Last weekend, that democracy was in action, as Democrats Abroad held three days of global meetings in Washington, DC. Thanks to the DA Travel Fund, one our members, Annie Tanampai, was able to attend, and DA funded many more of us participating from afar via WebEx.
But fewer than 1% of DA members donate to help us defend this democracy. Please help us change this. Donate Now to Democrats Abroad on a global level. DA provides the resources for us to do what we need to do - from paying for phone calls to our members to social media advertising that helps us get out the vote among the millions of overseas Americans in Belgium and around the world. Our donations really do make a difference, as you saw in our Treasurer's Report at our March Annual General Meeting. So please make a donation now.
I also encourage you to join our Global Caucuses. You can read more about them on DA's website, as well as meeting the newly-elected International Executive Committee. The Caucuses are open to all allies of the various groups so consider signing up, following them on social media, and even volunteering.
Here in Belgium, our events continue into June, thanks to our many volunteers!
- June 6th 6:30pm - Schaerbeek Pub Social - RSVP here
- June 12th 6:30pm - Brussels Film Night - Michael Moore's Fahrenheit 11/9 - RSVP here
- June 27th - Extended ExCom Meeting & Debate Watch Party - pencil in the date and stay tuned for more details in our next email.
If any of you outside Brussels would like to organize a similar event and help us reach more Americans beyond the capital, please do get in touch with us! This is the time for us to raise awareness, ahead of our January 2020 voter registration drive.
A special shout out to the Leuven gang who helped register American exchange & graduate students at the university twice this year…they enjoyed a well-deserved drink on Election Night!
In Brussels, we watched Fox, CNN, and MSNBC until 5am in the same warm setting where we saw many a presidential debate in 2016.
Brussels Women's March Anniversary Event
DAB was proud to join the Lights 4 Rights group to mark the one year anniversary of our 2000-strong Brussels Women's March. The beautiful voices of Indigo Creative asbl led us in song (video on our Friends of Democrats Abroad Facebook page!) and we even able to give voting information to a few new Americans. If you haven't already requested your absentee ballots for 2018, be sure to go to www.VoteFromAbroad.org. See you at our next event, this coming Thursday!
Health Care Landscape Part 2
We were very happy to welcome on November 6th Paula Jakub, the CEO of the AFSPA, which administers health insurance as part of the Federal Health Benefits program. Paula is also the Executive Director of the Senior Living Foundation and spoke to us of her learnings from running this non-profit organization that is devoted to helping elderly Foreign Service retirees and survivors. She also answered our questions on Medicare and Medicaid, Essential Health Benefits, long-term health insurance, pre-existing conditions, and the latest on the state of the Affordable Care Act. A special thanks to volunteer Sandra Keegan for having organized the comfortable venue, which helped soften the blow for some of us who realized we might never be able to move back to the US for a simple lack of affordable health care!
To all our members, please take part in the Tiny Action on Health Care - take a selfie in support of Universal Health Care - details on http://www.democratsabroad.org/healthcare_stories.
It's Back to School Time!
Thanks to the efforts of our determined GOTV Director, Tiffany Fliss, DAB was at KU Leuven's International Student Orientation Activity Fair on September 20th. Leuven DAB member Kevin Bardool and Chair Pauline Manos helped sign-up a dozen or so American citizens and encouraged all the other curious students (especially attracted by DA Germany's "Make America Gay Again" postcard!) to help us spread the word.
Scenes from a Civilized Debate between a Democrat and a Republican
DA Belgium Chair, Pauline Manos, and Republicans Overseas Chair, Mike Kulbickas, spoke on a September 14th panel sponsored by the Université Libre de Bruxelles Extension Program at La Louvière: L' Amérique de Donald Trump....200 jours plus tard! It was a refreshingly civilized discussion (with even a few laughs) that covered a wide range of topics, from the values of each party to the history behind divergent views on issues from health care to foreign policy to immigration, with many thoughtful questions from the 70+ attendees. Our warm thanks to moderators Jean-Paul Renier and Salvatore Ribaudo for allowing us to move out of our "Brussels Bubble".
THIS is DAB!!!
No pics, but we had a great Pub Social on August 16th - here's what our crowd looked like:
- age range: late 20s to 65+
- time in Belgium: two weeks to 40+ years
- political persuasion: self-proclaimed sort-of anarchist to fiscally conservative
- voting states: CA, FL, NM, NC, OR, and more
And our "Friends of DAB": Wallon, Flemish, Bruxelloise, British, and a couple of D.C. tourists and a vacationing American working in Senegal
Our Art Nouveau Walking Tour & Pub Social, 10 June 2017
Thank you, Paula Romanchak Cagli, for a great intro to Brussels' Art Nouveau treasures...a welcome reprieve from an intense political week!!!
This St-Gilles walking tour was guided by long-time DAB member, Paula Cagli, who holds a BA and an MA in Art History. After the tour, we moved on to a local pub for drinks and eats.
Our Health Care Event Follow-Up: 16 May 2017
Half of all Americans are insured by the government via Medicare (for the elderly) or Medicaid (for the poor) - that was a surprise for many of us.
Nearly a third of Americans are covered by employer-based health plans, which the ACA mandated for companies of 50+ employees and which need to cover ten Essential Benefits.
20MM Americans gained access to insurance via the ACA; it is virtually the only way for an individual to purchase affordable insurance in the US's group-oriented/profit-driven market.
The AHCA (current House version) allows states to waive Essential Benefits, eliminates low-income subsidies for premiums, and cuts the taxes that were funding those subsidies and other parts of the plan.
The AHCA tax cuts are estimated to transfer $274 BILLION to the top 2% of US taxpayers…a reverse Robin Hood plan that shifts from the poor to the rich.
If we want to hold on to the more critical parts of the ACA, we'll simply need a Democratic Congress….so stay registered to vote from abroad and make sure your American friends and family do the same ;-)
Update from our Annual General Meeting and Executive Committee Election results
- Chair - Pauline Manos - email@example.com
- Vice-Chair - Jeffrey Edison - firstname.lastname@example.com
- Secretary - Simone Burger - email@example.com
- Treasurer - Sharon Bronzwaer - firstname.lastname@example.com
- Counsel - Natalie McNelis - email@example.com
- Member-at-Large - Tiffany Fliss - email@example.com
- Member-at-Large - Meredith Tandy-Spangenberg - email@example.com
We hope to see you on April 22nd at the Science March Brussels or at our May 16th US Health Care Discussion (details to follow but pencil in the date). And, given the time of year, you may also want to take a look at the DA Fatca Update that was recently posted on the global website.


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Its 12.05pm and the letterbox has just rattled. A moment of silence follows and then my son, Karl, has come in with the "Post", "Post", "Post"! Only one letter and it is addressed to me. I open it read the first few lines and hand it to my wife who reads it and smiles. Through her smile it is obvious that she is deeply pondering what it all means both for me and for her and for us as a family. It reads "Dear Fergal, Thank you for the interest you have expressed in the Permanent Diaconate and for attending interview. The interview panel has recommended you as a suitable candidate"
That is all I need to read and I am relieved, delighted, nervous and unsure all at the same time. I think it is because I realise now that indeed history is being made in this Diocese and I am beginning to feel that weight of it all already. How will folk react to the news that I could, with the grace of God, be one of the first permanent Deacons in this Diocese. How will my parents, siblings and relations react? My kids, my neighbours? My colleagues at work how will it go down there? Its all spinning around in my head. It is all becoming very real now. It is like waking from a pleasant dream only to find out that your dream is continuing in reality. I can't describe it any better than that I'm afraid after all I am a man of the sciences!!
At the same time I am reminded of the words of the Priest from Carlow with whom I had my initial meeting. He told me in all sincerity that, by following this path the Lord seems to be calling me to travel, there is a lot of heartbreak ahead. They did not impact on me right away but they are impacting on me now. The more I think of this the more I am overawed by the significance of his words. I think of Our Blessed Lady and what she was told by Simeon as she and St Joseph presented Jesus in the temple. "Et tuam ipsíus ánimam pertransíbit gládius" which translates to something like And a sword of shall pierce your own soul too. These words were spoken to Mary by Simeon at the start of what was her motherhood to Christ.
So what is my response to be? For now let it be as was Mary's response. Lord give me the grace to take the time ahead to ponder deeply within my heart all that the you have done for me.
Múlier, ecce fílius tuus, Totus Tuus!


text:
Aug 2019
Aug 2019
Posted By: Tatyana Vandich In: Blog, Tags: fast healthcare interoperability resources, health information exchange, Health Level 7, HL7, HL7 FHIR, HL7 Standards 0 Comments
HL7 – Health information exchange Digital transformation has affected many industries and processes. One of the processes affected is Health Information Exchange — HIE. It is evident, that effective exchange of medical data between various health institutions allows serving more people and could reduce the cost of treatment. In this article, we will discuss …Learn More