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Avoid These 7 Foods Before Sleep To Avoid Insomnia And Have Deep Sleep
In this world, nowadays, many of you may be suffering from insomnia. It can be due to any of the reasons, maybe due to overweight, anxiety, depression, stress, or overthinking.
Here are a few things you are already aware of but there is more truth to it.
Your insomniac behavior also depends on the food, which you take before sleep. Some foods really ruin your chance to have a deep sleep. Moreover, that rule, 'don't eat past 8′, it's hundred percent true. So, let's see those food items which you should not have before sleep.
Well, you already know the reason for it. Caffeine stimulates the central nervous system several hours after consuming it. In addition, if you have taken it before sleep, then you will just lie awake the whole night and the next day, you will get trouble. So, try to avoid it for sure.
We know how much you love chocolates and many of you may like to consume it during the night, but according to research, it is not good to consume it before sleep. Chocolate also contains caffeine and caffeine prevents your body from shutting down, increase arousal and whatnot.
It would be better if you will have dessert many hours before sleep, so you can sleep without interruption.
Well, you may find it weird as you have always heard of alcohol as a relaxant. Yes, indeed it is, it helps in relaxing the muscle.
If you are having a glass of wine just before the bed, you will feel relax, for sure, but you won't be able to have complete REM cycle, which will prevent you for having truly restful colors and have a good sleep.
It is never a good idea to consume fatty foods before sleep. Food like burgers, pizza and all those fatty foods that you are dying to consumer bad for a good sleep.
As you know, fatty foods take a little longer to digest. The body keeps working than relaxing it. Then, they cause indigestion and bloating of food. Because of this, you get restless sleep.
Fatty high sugar cereals are always a bad idea if you want to have it before sleep. This makes your blood sugar spikes up and you will have a restless sleep that can have an effect on your mood later.
So, always choose a cereal with less than five grams of sugar per serving.
We know that spicy foods are food, which helps in boosting metabolism, but it is also something that doesn't give relaxation to your body. It increases the temperature of the body and also increases the metabolism.
If you will have a high protein diet, it reduces the serotonin. Serotonin is the calming hormone that promotes sleep, but, when you take it before the sleep, it reduces the chances of good sleep.
The post Avoid These 7 Foods Before Sleep To Avoid Insomnia And Have Deep Sleep appeared first on Remedies Lore.


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Centurions Alumni
Centurions Alumni Association (CAA) provides alumni with unique programming, community involvement, and resources to help them keep in touch with each other and the active program. Through this ongoing involvement, alumni can serve their community well after they graduate while staying connected to Centurions classmates as they grow into Kansas City's leadership.
CAA also provides:
- Assistance and support to the Centurions Leadership Program, the Greater Kansas City Chamber of Commerce, and other community organizations.
- A forum for members to discuss and learn about community issues.
- Association members with opportunities to become and stay actively involved on boards and commissions and in community affairs.
- An awareness of community issues, resources, and diversity.
Each member's investment helps to fund projects and resources that make the program successful, including:
- Stewardship of the Centurions Alumni Association Foundation, which annually awards two partial Centurions scholarships for small business candidates.
- Planning and operating several social and service activities throughout the year, including:
- Events centered on civic issues and leaders
- Annual holiday party
- Alumni social events
- Awards reception with actives
- Annual meeting and elections
- Raising awareness of and overseeing the nomination and award process for the Bernard Powell Award, named for one of the program's most memorable charter members
2018-19 Alumni Board
Jennifer Matney, Class of 2016
President Elect
Jon Hile, Class of 2012
Past President
Jennifer Kraenzle, Class of 2013
Past Active Steering Committee Chair
Shalea Walter, Class of 2019
Sara Harris, Class of 2018
Lathem Scott, Class of 2017
Legacy Fundraiser Co-Chairs
Leslie Dickerson, Class of 2018
Angie Grant, Class of 2018
Jackie Vavroch, Class of 2018
Membership and Communications Co-Chairs
Estuardo Garcia, Class of 2019
Austin Bickford, Class of 2017
Projects Co-Chairs
Meredith Webster, Class of 2018
Rhonda Dolan, Class of 2018
Civic Initiatives Co-Chairs
Jason Carter-Solomon, Class of 2018
Chris Vukas, Class of 2014
Social Co-Chairs
Theresa Garza, Class of 2019
Frank White III, Class of 2019

subset: commoncrawl


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Success for Homeless Christmas Shoebox Appeal
Caption: Mayor of Ferndown with the boxes
Charity, Latest News | Posted: Monday, December 17th, 2018 at 1:23 pm | return to news
Success for Homeless Christmas Shoebox Appeal
There has been a phenomenal response with over 500 boxes donated.
Caption: Mayor of Ferndown with the boxes
This year the appeal has been in memory of the late Cllr Steve Lugg, who introduced the appeal 2 years ago and was such a big driving force behind it.
Local Co-ordinator for the appeal, Rachel Taylor, from East Dorset District Council commented, "This year's response is a great sentiment to Steve's legacy. Thank you to everyone across Ferndown, Wimborne, Colehill and beyond who has supported the campaign."
The appeal was launched in September with the Mayors of Wimborne Minster and Ferndown joining forces in the campaign to encourage residents across the two towns and surrounding parishes to donate shoeboxes to drop off points – and what a response there's been.
As Christmas has approached the boxes have come in in their droves – all beautifully wrapped and jam packed with necessary items such as toiletries, hats, gloves and sachets of drinks/soups as well as a few sweet treats thrown in to the mix. Many boxes included a Christmas card for the recipient to open on Christmas day. All boxes will be donated to the Help The Homeless Charity and distributed locally.
The Mayor of Ferndown, Cllr Jean Read, said, "I am simply overwhelmed by the generosity of people this year. I was delighted to be approached by one resident who donated £100 to purchase goods for boxes and I thoroughly enjoyed wrapping and filling the boxes. Each box donated will go a long way in spreading a little joy to a homeless person's Christmas. I'd like to thank every person and organisation who has donated to the appeal, and Meridian Air Conditioning who has been Ferndown's drop-off point for the boxes for a second year."
Cllr Kelly Webb, the Mayor of Wimborne Minster added, "It is heart warming that so many people took the time to carefully put these boxes together. Our town should be very proud that we come together as a community to help others at this time of year that is so difficult for homeless people. Thank you to all those that took part in this worthwhile initiative."
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In 1 Timothy, Paul is equipping Timothy with the simple truth of the gospel. The motivation for such a charge stems from the burgeoning departure from the faith that was affecting the church. And as Paul continues writing to his beloved disciple in 1 Timothy 4, he details the nature of this departure as nothing more than an abandonment of the simplicity of "sound doctrine."
"Indeed, we have all received grace upon grace from his fullness." (John 1:16)


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Essay on Manufacturing Industry : Replace Assembly Line Workers
Essay on Manufacturing Industry : Replace Assembly Line Workers
Length: 2056 words (5.9 double-spaced pages)
Rating: Strong Essays
Essay Preview
The main problem is that employees are faced with unsafe conditions at work. After being tested for chromium poisoning, multiple workers at the Nippon Sharyo facility showed high levels of a human carcinogen caused by chromium (Fortino). As evident at this rail car assembly plant, working violations do still exists, and not all of them are being solved. This factory has already been fined for inadequate ventilation before, a problem that is still there on the facility (Fortino). In other words, the original problems were never solved and other than the payment of the fine, there hasn't been much done to improve the conditions at the factory. In conclusion, there are still safety violations in factories here in the US, and they are not being fixed.
Manufacturers that do not integrate industrial robots in facto...
... middle of paper ...
...ust like with any other piece of technology, automation will progress over time. will Shaped by new problems like compatibility and programming, improvements are constantly be made to counteract the complications.
Industrial robots should be brought into the the manufacturing industry because of all of the benefits they would bring into the workplace. With the help of robots, the workers at Nippon Sharyo would not have to suffer and face poor working conditions. Employees would watch over a factory of robots instead of doing dangerous work themselves. Jobs will be higher paying with more benefits, and productivity will rise. The integration of industrial robots is a must for manufacturers to survive in this competitive society. The use of robots will not be a detriment to the workplace. Instead, it is just the next step in the evolution of factory work, so why wait?
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Time Is An Important Lean Manufacturing Concept That Was Developed By Toyota Help Balance Production
- Introduction Takt time is an important lean manufacturing concept that was developed by Toyota to help balance production lines and optimize process flow. To define the term more specifically takt time is expressed in seconds and is used to determine the "rate of customer demand by dividing daily demand in units into the time available for production" (Mann, 2010, p. 270). It important to note that takt time is performed for individual processes so that each step in manufacturing is balanced to takt time, or as equal in length of time as possible.... [tags: Lean manufacturing, Manufacturing]
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- Since its inception, the Toyota Motors Manufacturing, USA, Inc. (TMM) has been able to make tremendous improvements in terms of production levels, quality, and efficiency. The company produces, power train, engines, and axles which are then forwarded to the sheet metal stamping, plastic molding, painting, body welding, and assemble sections. In all the sections, TMM has implemented Toyota Production System (TPS) and other management tools to guide the daily processes. The various support functions have also benefited from the TPS and other quality management tools with the outcome being increases productivity and production of high quality cars.... [tags: Toyota Production System, Toyota, Toyota Camry]
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- The Value of the Assembly Line in Automobile Manufacture In 1913, an innovation in automobile manufacture was born when Ford Motors experimented with winches and ropes to pull the chassis down a line while the assemblers stood in one place with their parts piles. The old process where workers moved in teams down the line, receiving their car parts from "parts runners" at each chassis as they arrived, was replaced by the automated assembly line, thus radically reducing by about 70 percent the original 17-hour labor input in the traditional moving team system.... [tags: BMW Auto Manufacturing Assembly Line]
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- The assembly line and its consequence upon humanity. The core concept of the assembly line is that production involves materials, and people, and that by moving either materials or people, the speed of assembling the manufactured good from various processed materials can be increased. And the application of this study, benefits humanity in a variety of ways, such as when applied to slaughterhouses and bakeries, bread and meat can be processed from grains and carcasses to feed more people and faster.... [tags: Assembly line, Manufacturing, Laborer, Costs]
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MLB Pick'Em 04/05
Welcome, valued friends, to MLB Pick'Em 2017! We are still celebrating the well-known fact that we have been above .500 in our picks for two days in a row. We'd stop the party, but that wouldn't be the trademark of the multiple day winners that we know ourselves to be.
April Yesterday (4th), 2017 Picks:
Tigers vs White Sox, pick White Sox, LOST
Yankees vs Rays, pick Yankees, WON
Rockies vs Brewers, pick Rockies, WON
Indians vs Rangers, pick Rangers, LOST
Mariners vs Astros, pick Mariners, LOST
Cubs vs Cardinals, pick Cubs, WON
Giants vs Diamondbacks, pick Giants, WON
Angels vs Athletics, pick Angels, WON
Padres vs Dodgers, pick Dodgers, LOST
Yesterday's Record: 5-4
Monthly Record: 13-10
Yearly Record: 13-10
April Today (5th), 2017 Picks:
Royals (Kennedy) vs Twins (Santiago)
These are two pretty similar pitchers as far as career stats go. If the pitching matchups are a wash, the second criteria is offenses (obviously). I believe the Royals have a better offense than the Twins. I'm picking Kansas City to get win #1 this season.
Pick: Royals
Cubs (Lackey) vs Cardinals (Lynn)
I have never been a John Lackey fan. Even when he was with the Angels I thought he was overrated. Then he got a massive deal with the Red Sox and never lived up to it. He has gotten better later in his career in my opinion but I still don't trust him all that much. I think that Lance Lynn and the Cardinals win this game and the series.
Pick: Cardinals
Tigers (Zimmermann) vs White Sox (Shields)
Color me shocked that "Big Game James" is still on a Major League Roster. He had one of the worst years I have ever seen last year, and yet here he is back at it again. Until he proves me wrong he is going to be the one pitcher I go against every time he is on the mound. Doesn't matter who is facing him.
Pick: Tigers
Toronto (Happ) vs Orioles (Bundy)
J.A Happ is one of those pitchers that as soon as he leaves the Seattle Mariners he becomes really good. That is a theme that you will see more than once today in influencing these picks. I think Dylan Bundy has the potential to do some damage this year, but I'm rolling with Happ and the Blue Jays to win pretty comfortably in this one.
Pick: Blue Jays
Marlins (Straily) vs Nationals (Roark)
In 2015, Tanner Roark was moved to the bullpen and wasn't happy about it and his pitching suffered. In 2016, he was moved back to the starting rotation and was happy about it and his pitching blossomed. I like Roark a lot this year as a #3 starter for the Nationals. He will build on that strong 2016, and have his best year this year.
Pick: Nationals
Pirates (Taillon) vs Red Sox (Sale)
The much anticipated Red Sox debut of Chris Sale! I universally like the prospects the White Sox got for Sale (not for this year obviously), but this is one of the top five pitchers in all of baseball, in his prime getting traded. He has to be jacked to be on a winning team and he will carve up an overrated Pirates lineup.
Pick: Red Sox
Phillies (Eickhoff) vs Reds (Finnegan)
Little known fact about Brandon Finnegan. He is the only player in baseball history to throw in the College World Series and the MLB World Series in the same year. That means he has to be pretty good right? Gut tells me that he is and he leads the Reds to victory.
Pick: Reds
Braves (Colon) vs Mets (DeGrom)
How Bartolo Colon hasn't eaten himself out of the league is beyond me. How he is has been a successful pitcher the last few years actually boggles my mind. DeGrom is another one of the stud young kids for the Mets, and he will sadly (they all loved Colon) lead them to victory over his former teammate.
Pick: Mets
Yankees (Pineda) vs Rays (Cobb)
Is this the year Pineda finally puts it all together for the Yankees? He has been close so many times but hasn't reached that upper echelon yet. He has all the talent in the world to put it together. My belly says he will mix in great starts with some absolute duds. This will be one of the former.
Pick: Yankees
Indians (Salazar) vs Rangers (Hamels)
Two pitchers that are worthy of opening day status is why most experts are picking these two teams for the playoffs. These two are both very efficient strikeout pitchers and I expect a low scoring game in this one. I said the same thing about Kluber vs Darvish, but Kluber had blisters and Darvish just seemed a bit off. I think these two are ready to go, but Hamels experience gives the edge to the Rangers for me.
Pick: Rangers
Rockies (Chatwood) vs Brewers (Peralta)
I think the Rockies could have an interesting year. I like their offense (even away from Coors Field) and they have loaded up with young arms on the pitching staff. This team might be a year away from contention, but I think they will be a fun team to watch. The Brewers meanwhile, will be fun only when they are on base as they will lead the league in both stolen bases and caught stealing. That is about it for the Brewers in my opinion.
Pick: Rockies
Mariners (Paxton) vs Astros (Morton)
You (might have) heard it here first folks. James Paxton will be the best Mariners starting pitcher this year for as long as he is healthy. That last part is really the only concern with Paxton. The stuff and make up is there. The durability is not. But he is healthy now so he leads the Mariners to victory.
Pick: Mariners
Giants (Moore) vs Diamondbacks (Walker)
Another old Mariners pitcher is Taijuan Walker. He usually excels in April and many hitters in the National League won't know him all that well. I think he is going to get off to a very fast start in Arizona this year.
Pick: Diamondbacks
Angels (Richards) vs Athletics (Cotton)
I am very intrigued to see Garrett Richards pitch this year. After electing stem therapy in lieu of Tommy John surgery, this will be an interesting case. Before he got injured Richards was becoming one of the best pitchers in the American League. Will he continue on that track or breakdown again? I will be keeping a very close eye on him this year.
Pick: Angels
Padres (Cahill) vs Dodgers (Hill)
Because I can't pick against the Padres in every game this year (even though I may want too).
ick: Padres


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what we did today
We're sick of this apartment, and there's only so much Brooklyn Nine-Nine a family can watch.
So naturally, we headed to the Texas Renaissance Festival today. That's right, friends: giant turkey legs, bad English accents and inexplicable costumes.
(No, really: it's stunning how many people interpret "Renaissance Festival attire" to mean "dress like Morris Day of The Time.")
Two dear friends, who don't even know each other, collectively made me this incredible gift.
A sweet taste of Trinidad
We did a little celebrating this weekend.
Because nothing beats boredom than people pretending to be British.
Time for some downtime.
Rami Malek is Freddie Mercury.
Don't tell my mom I posted this, okay?
I probably would've gotten a better grade if my high school biology class was like this.
No one likes a camp counsellor with a sense of humour, man.
Hamilton isn't the "overnight success" you might think it to be.


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This year was our best Read more →
*** OPEN HOUSE *** This Sunday, 2-4 pm 673 Augusta Drive #ygk this beautiful home is a must see! https://t.co/iDiDfbo1Iv
A team approach to exceptional Real Estate service
This year was our best year so far! We were able to donate $17,598.27 to […]Details


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HC-252-KM: Preventing Duplicate Instances of Hitachi VSP EnclosuresJune 22, 2016
Patch for Hardware Sentry KM for PATROL - Version(s) 1.8.01, 1.8.02, 1.9.00, 1.9.50
Patch content
Connector for Hitachi HDS USP/VSP Storage Systems
Should you install this patch?
Install this patch if you are seeing multiple VSP enclosures or if you are not receiving environment alerts when monitoring Hitachi HDS USP/VSP Storage Systems.
What does it fix?
This patch:
- prevents multiple monitoring instances of Hitachi VSP enclosures
- fixes a reception issue with environment alerts
How to install the patch?
- Copy the following file to the %PATROL_HOME%\lib\MS_HW_hdf or the $PATROL_HOME/lib/MS_HW_hdf directory on the server where the PATROL Agent runs:
- MS_HW_HitachiVSPSNMP.hdf
- Re-initialize Hardware Sentry. Nothing needs to be installed on Console systems.


text:
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text:
Credit where credit is due
LETTER OF CREDIT didn't get much of a run in the Galway Plate at the festival meeting, but hopefully won't face as many traffic problems at Ballybrit on Wednesday.
Jimmy Mangan's charge was badly hampered at the first two fences in the Plate and did well to finish mid-division in the end considering how far back he found himself. With only six runners in the Ryans Cleaning Chase on Wednesday night, he's unlikely to meet the same trouble.
He had been a good winner on his previous outing at Killarney in May when beating a decent field and a repeat of that would be good enough. It looks significant that his three wins over fences have come in small field events, which seem to suit him better, and as top-rated in tonight's event he looks to have found another nice opportunity.
Urano is sure to prove popular given his connections but he found disappointingly little in the Galway Blazers after cruising into contention turning for home.
Perfect Promise stuck on to take second then and it would be no surprise to see her finish in front again.
Gold Bullet is a decent sort on his day but hasn't really shone lately and even his run over timber Cork last time was a moderate enough effort.
Ruby Walsh looks to have another good book of rides tonight for Willie Mullins and the pair can collect with Daisy's Gift in the mares hurdle. She makes her first start since going down to Sandymount Duke at Tipperary in July and that looks a good effort with the winner scoring twice before that and again since.
The lightly-raced daughter of Presenting looked all set to prevail that day, jumping the second last, but was just outstayed in the end and the drop back to two-and-a-half miles should help now. It looks significant that she is preferred to stable-mate Valyssa Monterg, who is top-rated in the field but has to bounce back from a tame effort in Killarney.
Credo Star has run well to finish runner-up on her last two outings, including behind Sandymount Duke at Galway, and could be the danger getting weight.
Waaheb looked to have a bit to learn jumping wise when running twice over fences here at the festival but definitely showed improvement on the second day and looks to have found a handy enough race now in the beginners chase.
Iffjack is only moderate but should land a weak maiden hurdle, which opens the card, while Rosshaven Lady bids to redeem herself in the bumper after running out at Killarney when last seen.


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England's hat trick hero and World Cup winner, Sir Geoff Hurst will talk amusingly about his illustrious West Ham & England career.
Hurst is back on tour by popular demand with his great friend and agent, Terry Baker from A1 Sporting Speakers.
VIP ticket holders will have a chance to meet Sir Geoff and have a photograph with him before the show.
The second half will be a Q&A session with the audience.
This will be a great event for football fans.
VIP Tickets: £51 (includes meet & greet)
Tickets: £26
A £1 ticket levy is included in all stated ticket prices.
Tue 17 Sep
Sat 21 Sep , 15:00


text: Endless Praise AdorationDDeclarationFastGospel Vol. 2: Every PraisePraiseThe Recording Collective Description Download sheet music for Endless Praise by The Recording Collective, from the album, Gospel Vol. 2: Every Praise. Products for this song include Rhythm-Vocal Chart, Rhythm Chart, and Chord Chart. https://www.gospelmaps.com/wp-content/uploads/edd/2018/12/Endless-Praise-The-Recording-Collective-sample.mp3 Artist: The Recording Collective Album: Gospel Vol. 2: Every Praise Key: D Tempo: Fast Themes: Praise, Declaration, Adoration Rhythm-Vocal – $9.00 x Rhythm Chart – $5.00 x Chord Chart – $5.00 x Purchase Checkout Added to cart


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Who: HighRoad Golfers & Backyard Fiesta Lovers
When: Saturday, July 27th, 2019
First tee time is 11:00 AM
Where: Red Tail Golf Course, 7900 Redtail Dr, Village of Lakewood, IL 60014
Dinner at 5:00PM @ Scott and Anne's House in Lakewood
Cost: $60 for golf, prizes and dinner.
If you don't golf but would still like to join in the party $10 for dinner only.
PLEASE RSVP by July 15th to firstname.lastname@example.com


text:
round two
December 8, 2018
Okay, here's the next set of bests:
- Book Marks – The Best Reviewed Books of 2018: Poetry
- Entropy – Best of 2018: Best Poetry Books & Poetry Collections
- Goodreads Choice Awards 2018 – Poetry
- The Listener (New Zealand) – 10 Best Poetry Books of 2018
- The New Yorker – The Poetry I Was Grateful For in 2018 by Dan Chiasson
- NPR's Book Concierge – Our Guide To 2018's Great Reads (Short Stories, Essays & Poetry)
- The Times (London) – Best poetry books of 2018
Tonight: peaceful poetry
December 5, 2018
Come spend an hour honoring some of Whatcom County's talented young writers as winners of the 2018 Youth Peace Poetry Contest read their poems. Presented by the Whatcom Dispute Resolution Center and Village Books, the reading starts at 6:30pm in the Village Books Readings Gallery in Bellingham. Luther Allen emcees.
I'm Just A Gal*
December 2, 2018
2018 Merit Award
By Megan Gillikin, grade 4
I'm just a gal walking into town,
Don't really care if people stare.
With my big pink bright purse,
I hold the universe.
With my dark shiny blue coat
I don't have to gloat.
With my bright yellow boots,
I turn and stare and there I see another me.
I'm just a gal walking in to town.
. . . . .
Hi, my name is Megan Gillikin. I attend Happy Valley Elementary. I love spending time outdoors and with my family. Some of my hobbies are drawing, climbing trees, writing, and swimming.
Inspiration for writing "I'm Just a Gal" came to me when in Texas while driving across country with my mom. We stopped at a gas station and the attendant called me, gal. As I looked about I noticed how people spoke with one another and that many wore cowboy boots. At the time, I had bought a big pink purse to hold a lot of toys so I wouldn't be bored in the car and I felt I held the Universe.
I'm very happy my poem was selected, I hope you enjoy it.
. . . . .
*Copyright 2018 by Megan Gillikin. Broadside illustrated by Kim Wulfestieg.
Let it begin!
December 1, 2018
One of our favorite signs of the year-end holidays is the pile-up of "year's best poetry" lists. It's always interesting to see which books make the lists, and which ones appear on multiple lists. The listing has begun, so let's get started:
- The Financial Times – Best books of 2018: Poetry
- The Guardian – Top 10 poetry anthologies
- Publishers Weekly – Best Books 2018 – Poetry
- Publishers Weekly – Holiday Gift Guide 2018: Poetry
- The Washington Post – The 5 best poetry collections of 2018
If you ask*
November 25, 2018
2018 Merit Award
By Jackie Lomas, grade 12
If you ask me
I'll tell you about the life in the hood,
To kneel beside you and watch you die
I'll tell about trees and how my life is a fallen leaf
I am evil without a heart.
I'll tell you about an argument that made me alone
A cold war, blood red mornings and a love no one knows,
You ask me I'll tell about poor man's vow to silence,
a girl's broken heart that led to her brothers grave I'll tell
you about a child's scar that never fades seventeen-year-
old boys' father never returns from work a baby born not
knowing whether to go left or right
we are all connected by our hearts and souls,
So, if you ask me I'll tell you about life
And it ends.
If you ask me I'll tell you about a family broken home
I'll tell you about the dark times in my Mind
If you ask I'll tell you about a friend who died,
about a girl who got bullied and committed suicide
If you ask I'll tell you about the abandoned child
If you ask I'll tell you about the girl who got raped
If you ask I'll tell you about the mother who ran away.
If you ask me I'll tell you.
. . . . .
*Copyright 2018 by Jackie Lomas. Broadside illustrated by Megan Carroll.
three percent
November 24, 2018
The New York Times has released its list of 100 Notable Books of 2018. Three volumes of poetry are included:
- Brown: Poems by Kevin Young
- The Odyssey by Homer
- Wade in the Water: Poems by Tracy K. Smith
Catch up with the complete list here.
November 18, 2018
2018 Merit Award
By Nora Whitley Abelite
Clouds of feathers numerous as snowflakes
Cacophony of honks, hums and whirs greet me at twilight
Crowded in gaggles they bed under a frosty moon.
At dawn they wake with breath rising into a misty sky
At dawn my heart thumps to their winged drum
At dawn they fly off to reap, glean and fatten.
Each day of winter, I seek their soaring splendor
Each day of winter, I count their growing numbers
Each day of winter, I wait for their return.
Then one warmer morning they fly away
Into a beckoning sky for their appointment
Thousands of miles north to the tundra,
Leaving the fallow, harrowed fields lonely
With a secret want for tulips.
. . . . .
*Copyright 2018 by Nora Whitley Abelite. Broadside illustrated by Angela Boyle.


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A broad range of research is needed to understand the impacts of climate change on food production systems and to develop strategies that assist in both limiting the magnitude of climate change through management practices and reducing vulnerability and increasing adaptive capacity in regions and populations in the United States and other parts of the world. Some critical research needs, which are explored in further detail in Chapter 10, are listed below.
• Improve understanding and models of response of agricultural crops and fisheries to climate and other environmental changes.
• Expand observing and monitoring systems.
• Assess food security and vulnerability in the context of climate change.
• Develop approaches to evaluate trade-offs and synergies in managing agricultural lands and in managing ocean resources.
• Develop and improve technologies, management strategies, and institutions to reduce GHG emissions from agriculture and fisheries and to enhance adaptation to climate change.
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In another piece of bad news for Samsung this week, the Galaxy Wearable app for Android devices is reportedly broken, with many users claiming to encounter sign-in problems.
According to a thread on Samsung's community forums, Galaxy users have been unable to log in to the companion app since at least Thursday. Users are instead greeted with a white screen, unable to backup their devices or install apps.
At the time of writing, the thread spans 75 pages, affecting multiple Android phones including the OnePlus 6, Huawei Mate 20 and Google Pixel 2 XL - but, interestingly, no Samsung devices.
[Related: The best phones of 2019 - so far]
Users around the world started complaining about the issue on Twitter in no time.
@SamsungHelpUK I'm trying to log into my Samsung acc on the Galaxy Wearable Android app but keep getting blank log in screen. Same on two phones. Do you have a problem?— Iain Mann (@iainmann) April 18, 2019
[Translation from German: @SamsungDE [Samsung Germany] The silly app has logged me out of the store because it says my session expired. Can I log back in? Nope, thanks to a white window…]
@SamsungDE Na, App meldet mich einfach so vom Store ab, weil meine Sitzung abgelaufen ist. Wieder anmelden? Fehlanzeige, dank weißem Fenster. Und nun? pic.twitter.com/8kkWpuXRpl— | (@der_schwabe) April 19, 2019
Read more: Samsung Q90 QLED 4K TV + Q70 Soundbar hands-on: The bright, the brilliant and the Bixby
@Samsung please fix the issue with the white screen when trying to login to Samsung account via galaxy wearable pic.twitter.com/feQTzxHSsj— Galatasaray_Media  (@gala_pictures) 22 April 2019
[Translation from Portuguese: @SamsungBrasil The Galaxy Wearable app won't let me log in to set up my Galaxy Watch. Now it's just a clock. Not happy.]
Read more: Samsung just revealed their weirdest and most inventive smartphone of the year
@SamsungBrasil O App Galaxy Wearable não está permitindo logar para configurar o Galaxy Watch. Isso transforma ele em apenas um relógio. Me arrependendo. #galaxywatch #samsung #galaxywearable— Rafael Peroco (@rafaelperoco) April 19, 2019
Some users have reported that the app is working again, though it's currently unclear whether this is due to a workaround found by Samsung user LarsN or whether the issue has been formally resolved on Samsung's end.
PC World Australia have reached out to Samsung Australia for comment.
Read more: Samsung Galaxy S10+ review: Bigger is better
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World Biggest Tenders Source
This tender with title Büromaterial + Logistik Druckerzeugnisse has been published on Bidding Source portal dated 15 Apr 2019 for the country of Germany. It has been categorized on Office supplies. For similar tenders you can see tenders mentioned below of this page.
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We will be closed for a private event Saturday evening, May 18th, 7-9pm.
Here at Taproom we love gathering people together. If you have an idea for an event you'd like to see us host, please let us know!
Back to All Events
Earlier Event: May 11Mother's Day Flower Pop-Up
Later Event: May 25Private Event


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The Bigger Picture
President Hassan Rouhani's landslide win in Iran elections is good news for India too
Oil is not the only factor in New Delhi-Tehran relations — connectivity is.
- Total Shares
President Hassan Rouhani's landslide victory in the presidential elections is good news for Iranians as well as for India. It should assist Iran to become more democratic, moderate and prosperous over time, but that is not a given.
His challenge is to overcome significant hurdles on his path, which arise from domestic politics, and an equally difficult challenge thrown up by the Donald Trump-led United States.
Economic reforms
Rouhani came to power in August 2013 promising economic reform. Despite vast oil resources, Iran's economy has remained moribund because it has not been able to get technology to exploit its resources effectively, or exploit the market when oil prices were riding high.
He set about the process by working out the nuclear deal with the US and other Western powers so as to persuade them to lift sanctions, which badly affected the Iranian economy. The sanctions have been lifted, but low oil prices are thwarting recovery. But the bigger problem is Iran's domestic politics.
The country is, at best, a quasi-democracy. Its system is structured so as to maintain the power of the clergy and their allies, the Islamic Revolutionary Guards Corps (IRGC). At the top is Supreme Leader Ayatollah Ali Khamenei who has a veto on virtually everything.
A supporter of Hassan Rouhani flashes a victory sign while celebrating his victory in the presidential election, in Tehran, Iran. (AP)
The legislature has two wings — the lower house or Consultative Assembly and the upper house, the Guardian Council. The former is like a regular Parliament with legislators elected through secret ballot. The latter has 12 members, of which half are clergy chosen by the Supreme Leader and the other half are jurists chosen by the lower house. The Guardian Council has a veto on all legislations.
The Supreme Leader is elected for life by an Assembly of Experts, a group of 88 top clergymen who are elected once in eight years through direct voting. In addition, there is the powerful Expediency Council of some 30-40 people chosen by the Supreme Leader to assist him in managing the system.
Ebrahim Raisi, the candidate Rouhani defeated, is a former judge and was spoken of as a potential successor to the 78-year old Khamenei. Both Rouhani and Raisi are clerics, and the latter has been a member of the Assembly of Experts since 2006.
Importance for India
The Iranian situation shows that elections alone do not make a democracy. The power of the Rouhani government is severely constrained at every step by the clergy. The IRGC, which is a parallel military organisation, complete with an army, navy and aerospace wings, has extensive business interests and serves as the storm trooper of the clergy. They are involved in domestic repression, and support Assad's forces against the ISIS.
Developments in Iran can have an important fallout in India. Last year, oil imports hit record levels and Iran became the fourth biggest oil supplier to India. This was because of the lifting of sanctions. Given its oil and gas resources and proximity to India, Iran's importance in the energy sector cannot be underestimated.
But oil is not the only factor in India-Iran relations — connectivity is. India has two projects in mind — the Chabahar port and related development scheme aimed at developing links to Central Asia and Afghanistan, and the International North South Transportation Corridor (INSTC) to connect western Indian ports through a multi-modal network to Europe via Iran.
During Prime Minister Narendra Modi's May 2016 visit, the two countries signed a $500 million (Rs 3,200 crore) agreement to develop the Chabahar port and fund a railway line to Zahedan. Further India indicated its interest in building an LNG plant in Chabahar economic development zone. New Delhi also returned $6 billion (Rs 3,900 crore), which was owed to Iran on the oil account during the sanction period.
Smoothening edges
The problem is that there are still rough edges to the India-Iran relationship. A deal to develop the Farzad B oil fields remains stuck. Little or nothing has been done on the INSTC front, except the running of test cargoes to Russian destinations. Properly pursued it can be India's answer to China's One Belt One Road, which also aims to use Iranian routes and already exploits the Russian ones.
Given the potential Iran offers, India has reasons to worry about the US-Iran dynamics. Should relations deteriorate, India may once again be forced to curtail its Iranian commitments, just as it had to do in the2007-2015 period.
Given New Delhi's compulsions to maintain good ties with the US, it would not like to buck Washington, and will thereby cede the ground to China which is unlikely to follow any new US lead in Iran.
(Courtesy of Mail Today.)
Also read: Saudi Arabia and Iran: Divided by politics, united by religious rhetoric


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Pamela Murphy
"If you don't believe in you, who will?"
What do you do and what led you to this career?
I am currently the Founder + Creative Director of The Select 7, a curated lifestyle website. I originally went to journalism school, and have always loved the art of creating community. These helped build the foundations of The Select 7.
What are the names and ages of your children?
Campbell, who is 15 years old; and Callen, who is 12 years old.
What has been your biggest career achievement thus far?
Starting this brand and website with literally no idea what I was doing and turning it into something I know and love has been my biggest career achievement.
What is the most rewarding aspect of being a mother?
Watching these people become people. Listening to their thoughts, opinions, and desires, and watching them become independent humans.
And what is the most challenging?
Every. Single. Thing.
What is your best advice for someone new to your industry?
Keep going. The road is long and it can feel endless, but just keep going. If you don't believe in you, who will?
What is your best advice for a new mother?
Pay attention. It all goes so fast. Just be there.
What's next for you? Do you have any exciting projects coming up?
We're launching a podcast, The Select Session soon!
Follow Pamela at @theselect7


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Following a conference presentation on remote spirit release, a group of attendees are asked for their opinion on this method of intervention for mental illness.
Adding Value to Medicine
Research methods are known and available for medicine to evaluate the efficacy of any medical or therapeutic intervention in the treatment of any specific illness. But no one is conducting research into the efficacy of Spirit Release Therapy or Remote Spirit Release methods in the treatment of mental illness. Why is that so? The diseases are there and the problems associated with treating them are growing. But the remedy is also there, so why is there no research to answer the question 'Do these methods work?
Here is a conference presentation that explains how a non-conventional treatment method can be integrated with the search for best practice in the treatment of psychosis with research and the training of skilled practitioners to solve the problem. All that is required is a scientific institution, a medical school, a psychiatric clinic or a university psychology research department to take the question seriously. This is an open invitation.
Hospital Earthbounds
Treating Dissociative Disorders with Telepathic Hypnosis
Transpersonal Psychology Section Annual Conference 2018
An Open Invitation to Research
Supernatural in Contemporary Society Conference (SCSC)
The conference will take place on Thursday 23 and Friday 24 August 2018.
I shall be presenting on cases of earthbound spirits in hospitals. Click on the image for further information.
The media reports ghostly encounters, supernatural TV and films continue to be popular genres, and professionalised groups and organisations offer commercial experiences of the otherworldly. It seems that regardless of scientific progress and rationale thought, the allure of the extraordinary still prevails.
The Supernatural in Contemporary Society Conference (SCSC) aims to explore the continuing role of the supernatural. SCSC intends to provide an interdisciplinary forum to discuss current and emerging research, and examine these in relation to the impact and value this has on culture, heritage and tourism. In addition, industry professionals are invited to discuss current and emerging issues.
Spirit Influence on Mental Health Conference
All presentations at the Spirit Release Forum conference in February at Regent's University in London have finally been released. Here is my own presentation on the topic of Medical Science and Spirit Influence. All other presentations can be seen on the Spirit Release Forum's You Tube channel. Any comments would be most welcome.
Afterlife Research Centre Workshop – Helsinki 2016
Spirit Influence on Mental Health Conference Report by Fiona Bowie
[Best_Wordpress_Gallery id="3″ gal_title="SRF conference 2017″]
Scroll through for photos of the speakers
Follow this link for Dr Bowie's report.


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Ryan Mayler
|Bio Statement
Howdy! I am Ryan. Thank you for visting my profile. I am a book worm and try to read one book a month. I have 2 kids whom I cherish very much. I really wish there were more hours in a day so I could get everything I want done. My favorite novels are Under the Net and The Corrections. There is so much I learned from them. If anyone is interested in chatting, feel free to message me.
Official Website: website
##journal.issn##: 1946-1879


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Carnosic acid (CA), a major polyphenolic diterpene present in Rosmarinus officinalis, has been reported to have multiple functions, including antitumor activity. The MTT assay, BrdU incorporation, wound healing, and colony formation were used to detect melanoma B16F10 cell growth and proliferation. Flow cytometry was used for cell cycle detection. p21 and p27 expression was detected by Western blotting. B16F10 cell xenograft model was established, and treated with CA, carmustine (BCNU), or lomustine (CCNU). The present study found that CA exhibits significant growth inhibition and cell cycle arrest in melanoma B16F10 cells. We also found that CA triggers cell cycle arrest at G0/G1 phase, and enhances p21 expression. Additionally, CA can enhance BCNU- and CCNU-mediated cytotoxicity and cell cycle arrest in B16F10 cells. Finally, we found that CA inhibits tumor growth, and reduces the values of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in vivo. The present study study concluded that CA may be safe and useful as a novel chemotherapeutic agent.
- carnosic acid
- cell cycle
- carmustine
- lomustine
Carnosic acid (CA), which is a major polyphenolic diterpene present in rosemary (Rosmarinus officinalis), has been reported to have multiple biological functions, including anti-inflammation, antivirus, and anticancer [1–3]. Some studies have demonstrated that CA inhibits proliferation and migration of cancer cells [2,4–6], and also reduces vascular endothelial growth factor expression [7]. Additionally, CA induces cell cycle arrest at the G2/M phase via down-regulation of cyclin A expression in leukemia and colon cancer cells [8–10]. Several previous studies have reported that CA induced apoptosis in human neuroblastoma and human prostate carcinoma cells [4,11]. CA inhibits the epithelial–mesenchymal transition (EMT) and migration of B16F10 cells in a dose-dependent manner [6]. Moreover, combined treatment by CA and curcumin induces apoptosis in acute myeloid leukemia cells via a caspase-8-mediated pathway [10]. Additionally, CA enhances sensitized TRAIL-mediated apoptosis in human carcinoma caki cells [12]. Hence, combined treatment with CA and other chemotherapy drugs may be a good strategy for cancer therapy.
Carmustine (BCNU) and lomustine (CCNU) are two of the nitrosoureas belonging to classical alkylating agents. BCNU is highly soluble in alcohol and lipids, and poorly soluble in water. CCNU is soluble in absolute alcohol and is relatively insoluble in water. Just like other nitrosoureas, these two drugs can also inhibit several enzymatic processes by carbamoylation of amino acids in proteins [13,14]. The high lipid solubility of BCNU and CCNU means that they cross the blood–brain barrier quite effectively. Researchers know that BCNU and CCNU are useful to treat brain tumors as a single agent or in established combination therapy with other chemotherapeutic drugs [15–18]. However, bone marrow suppression is the most common and severe toxic effect of BCNU and CCNU [19,20]. According to a previous study, CA enhances antiproliferation activity of cisplatin on human ovarian cancer cells [21]. Cisplatin is a platinum-based chemotherapeutic drug, and frequently designated as an alkylating agent. Although cisplatin does not have an alkyl group, it nevertheless damages the DNA and interferes with DNA repair. So cisplatin is classified as an alkylating-like agent. In the present study, we tried to estimate the combined effect of CA with alkylating agents (BCNU and CCNU) on melanoma in vitro and in vivo.
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT), two kinds of liver enzymes, can be found widely throughout the human body. AST is found primarily in many organs and tissues including heart, liver, skeletal muscle, and kidney. ALT is found primarily in liver and kidney [22,23]. Amongst the liver injury markers, ALT and AST are most commonly used. Liver diseases and injury are the main causes that increase ALT and AST plasma levels. Most forms of liver diseases and injury, plasma ALT levels are higher than that of AST. ALT is more specific than AST to be a liver injury marker [24]. Bilirubin is created by the breakdown of hemoglobin and passed on to the liver. Total bilirubin (TBIL) is composed of direct bilirubin and indirect bilirubin. When liver diseases or drug-induced liver injury occurs, the plasma levels of bilirubin will be higher than the normal. The liver function will be determined abnormal. High levels of bilirubin can cause jaundice, severe liver disease, and possibly cirrhosis [24]. Hence, TBIL is an important marker for liver function. In the human body, albumin (ALB) is the most abundant plasma protein, and is produced by hepatocytes. ALB is an important factor in maintaining plasma osmolality. It can be a source for other proteins synthesis. Additionally, ALB also functions as a transporter for drugs and hormones. Some diseases and injury cause plasma ALB levels to decrease, including nephrotic syndrome, burns, protein losing enteropathy, malnutrition, and liver disease [24,25]. For liver disease measurements, ALB is used as a marker to determine the progression, severity, decompensation, and prognosis of cirrhosis [26]. Therefore, current laboratory tests are important in the diagnosis and monitoring of liver injury and function. These tests focus on injury markers (AST and ALT) and functional markers (TBIL and ALB).
Melanoma is the most fatal kind of skin cancer. It is an important topic to investigate new strategies to treat cancer cells and decrease high death rates. B16F10 is a murine melanoma cell line, and is commonly used for melanoma research model. This cell line was isolated and maintained from a C57BL/6 mouse. Therefore, we use B16F10 cells and C57BL/6 mouse to estimate the treated effects of CA, BCNU, and CCNU in vitro and in vivo.
The present study investigates the regulation by CA of cell cycle distribution. CA arrests the cell cycle of B16F10 cells at the G0/G1 phase. We tested the plasma levels of AST, ALT, TBIL, and ALB after CA injection and B16F10 xenograft to evaluate liver injury and function. The combined effects of CA and BCNU or CCNU in B16F10 cells are also explored. Experimental results indicate that CA may enhance the anticancer effects of BCNU and CCNU in vitro and in vivo.
Materials and methods
Cell line and reagents
The melanoma cell line B16F10 used in the present study was purchased from Bioresource Collection and Research Center (BCRC; Hsinchu, Taiwan). All cells were cultured at 37°C under a 5% CO2 atmosphere and in Dulbecco's modified Eagle's medium (DMEM; Gibco®, Life Technologies™, U.S.A.) supplemented with 100 U/ml penicillin, 100 μg/ml streptomycin, and 10% heat-inactivated FBS (Gibco®, Life Technologies™, U.S.A.). CA was purchased from ChemFaces (ChemFaces, Wuhan, Hubei, China). The BCNU, CCNU, DMSO, RNase A, and propidium iodide (PI) were purchased from Sigma–Aldrich (St. Louis, MO, U.S.A.). The anti-p21, -p27, and -β-actin antibodies were purchased from GeneTex (GeneTex Inc.).
Cytotoxicity detection
To detect the cytotoxicity of CA, BCNU, and CCNU, B16F10 cells were seeded in 96-well plates at a density of 5 × 103 cells/well in DMEM supplemented with 10% FBS. Following an 18-h incubation at 37°C under a 5% CO2 atmosphere, the old medium was replaced with fresh DMEM/1% FBS containing CA (0, 5, 10, 15, 20, 25, 50, and 100 μM), BCNU (0, 1.57, 3.13, 6.25, 12.5, 25, 50, and 100 μM), or CCNU (0, 1.57, 3.13, 6.25, 12.5, 25, 50, and 100 μM). The MTT assay (Invitrogen, Thermo Fisher Scientific Inc.) was used to detect cytotoxicity after 24 h of incubation. The generated formazan products were solubilized by 100 μl DMSO, and the optical density was measured at 570 nm using an ELISA reader (infinite M200PRO, TECAN).
Cell proliferation assay
The B16F10 cells were seeded on cover glasses in 24-well plates at a density of 5 × 104 cells/cover glass. Following an 18-h incubation at 37°C under 5% CO2 atmosphere, the old medium was replaced with fresh DMEM/1% FBS containing CA (0, 1, 2, 5, 10, 15, 20, and 25 μM). Stimulation was performed for 24 h, during which BrdU was added to the medium for the last 1 h. BrdU incorporation was detected by BrdU Labeling and Detection Kit (Roche Diagnostics). The BrdU-labeled cells and nuclei were visualized by a fluorescence microscope (20×; Zeiss), and the images were analyzed by ImageJ software (National Institutes of Health, U.S.A.).
Wound healing assay
To perform the wound healing assay, B16F10 cells were seeded in six-well culture plates at 3 × 105 cells/well in DMEM/10% FBS and incubated over two nights at 37°C in 5% CO2 atmosphere. The cell monolayer was longitudinally scratched by a pipette tip to form a stripe. The culture medium was replaced with 1 ml fresh DMEM/1% FBS containing different concentrations of CA (0, 5, 10, and 15 μM). The cells were visualized and photographed by the inverted microscope at time 0, 12, and 24 h. The images were analyzed and quantitated by ImageJ software (National Institutes of Health, U.S.A.).
Soft agar colony formation assay
The B16F10 cells were pre-treated with CA (0, 5, 10, and 15 μM) for 24 h. The cells were then seeded (2 × 103 cells/well) into a six-well plate containing DMEM plus 10% FBS and CA (0, 5, 10, and 15 μM) in 0.4% agar above a layer of 0.6% agar. The cells were incubated at 37°C under a 5% CO2 atmosphere for 14 days, and the colonies were photographed and counted under an optical microscope (CKX41, OLYMPUS).
Cell cycle detection
The cell cycle was detected by treating B16F10 cells with CA (0, 2, 5, 10, and 15 μM) for 24 h. All cells were fixed in 70% ethanol/phosphate-buffered saline (PBS) at 4°C for 18 h, pelleted, and then resuspended in PBS containing 200 μg/ml RNase A and 0.01 mg/ml PI. The cell cycle was determined by flow cytometry (Cytomic FC 500, Beckman Coulter).
Western blotting
The B16F10 cells were seeded in 12-well plates at a density of 2 × 105 cells/well. The cells were treated with drugs for 24 h after 16 h of incubation. The cells were subsequently lysed in RIPA buffer (G-Biosciences, MO, U.S.A.) containing protease inhibitors (Roche Applied Science, Mannheim, Germany). The total extracted protein content (25 μg) was separated by SDS/PAGE, and transferred on to PVDF membranes. The PVDF membranes were incubated with primary antibodies at a dilution of 1:500 or 1:1000 to detect p21 (catalog number: GTX27960, GeneTex Inc., U.S.A.), p27 (catalog number: GTX55090, GeneTex Inc., U.S.A.), and β-actin (catalog number: GTX109639, GeneTex Inc., U.S.A.). The protein band density was quantitated by ImageJ software (National Institutes of Health, U.S.A.). The fold change in protein expression was expressed as a ratio calculated by dividing the p21 or p27 protein band density by the β-actin band density and then normalized to the control group.
Ethics approval and consent to participate
The present study was performed with standard operation protocols. The animal experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of E-Da Hospital (approval number: IACUC-103033).
Mouse xenograft model
Male C57BL/6 mice at 6–8 weeks of age were purchased from BioLASCO Taiwan Co., Ltd. The B16F10 cells (5 × 105 in 0.1 ml of PBS) were injected subcutaneously into the backs of the mice. Seven days after B16F10 cell injection, all mice were separated randomly into six groups: control (0.1 ml PBS) group, CA (50 mg/kg) treated group, BCNU (35 mg/kg) treated group, CCNU (50 mg/kg) treated group, CA + BCNU treated group, and CA + CCNU treated group. PBS or drugs were injected peritoneally every 2 days (n=5 for each group). The largest diameter and smallest diameter of the tumor were measured and the tumor volume (mm3) was calculated as largest diameter (mm) × smallest diameter2 (mm2)/2. Peripheral blood of mice was also accumulated. The amounts of AST, ALT, TBIL, and ALB in peripheral blood was measured by UniCel™ DxI 800 Immunoassay System (Beckman Coulter).
Statistical analysis
The data are presented as S.D. of three determinations (means ± S.D., n=3). The statistical significance of the differences between pairwise comparisons was determined using the unpaired Student's t test. P<0.01 was considered statistically significant.
CA inhibited cell growth in melanoma B16F10 cells
To explore the cytotoxic effect of CA, B16F10 cells were treated with CA (0, 1, 2, 5, 10, 15, 20, and 25 μM) for 24 h. Cell viability was measured by MTT assay. Cell proliferation was determined by BrdU incorporation. Experimental results indicate that CA significantly inhibited cell viability and proliferation of B16F10 cells (Figure 1A). The IC50 values of CA were calculated from the results of MTT and BrdU assays were approximately (7.08 ± 0.14) μM and (8.64 ± 1.02) μM, respectively. Additionally, soft agar colony formation assay and wound healing assay were adopted to detect cell growth of B16F10 cells. As indicated in Figure 1B,C, CA inhibited colony formation and wound healing of B16F10 cells significantly after incubation with CA (5, 10, and 15 μM). Moreover, flow cytometry was used to detect cell cycle of B16F10 cells following CA 24-h treatment. The percentage of G0/G1 phase increased significantly (Table 1). These data indicate that CA may inhibit cell growth and induce G0/G1 phase arrest in B16F10 cells.
CA enhanced the cytotoxic effects of BCNU and CCNU in B16F10 cells
To compare the cytotoxicity of CA, BCNU, and CCNU, B16F10 cells were treated with CA, BCNU, and CCNU for 24 h. The MTT assay was used to detect cell survival rate. CA had a better cytotoxic effect than BCNU or CCNU (Figure 2A). The combined effects of CA and BCNU or CCNU were determined. B16F10 cells were treated with CA alone, BCNU alone, CCNU alone, CA plus BCNU or CA plus CCNU. Cell survival rate and cell cycle distribution were detected by MTT assay and flow cytometry, respectively. As shown in Figure 2B,C, CA enhanced the cytotoxic effects of BCNU and CCNU. CA increased BCNU- or CCNU-induced cytotoxicity in B16F10 cells. Additionally, cell cycle distribution was detected by flow cytometry after PI staining. CA arrested cell cycle at G0/G1 phase, and BCNU and CCNU arrested cell cycle at G2/M phase. Additionally, 15 μM of CA enhanced BCNU- or CCNU-induced G2/M phase arrest (Tables 2 and 3).
CA regulated p21 and p27 protein expression
The expression levels of p21 and p27 were further detected. Researchers have previously reported that p21 and p27 play critical roles in cell cycle regulation. Up-regulation of p21 and p27 in many cancer cells can arrest cell cycle at G0/G1 and G2/M phase. To investigate the regulating effects of CA on p21 and p27, total protein was extracted from B16F10 cells with RIPA buffer after CA (2, 5, 10, and 15 μM) 24-h treatment. As shown in Figure 3, CA up-regulated p21 expression and down-regulated p27 expression of B16F10 cells within 24 h.
CA inhibited B16F10 tumor growth and enhanced antitumor effects of BCNU and CCNU
The B16F10 cells were xenografted to the back of C57BL/6 mice. After 7 days, the tumor size was measured every 2 days (Figure 4A). After 14 days, the tumors grew markedly, and the values of AST and ALT were enhanced significantly. However, the tumor growth did not significantly affect TBIL or ALB values (Table 4).
The normal mice were injected with CA (50 mg/kg) peritoneally every day for 7 days before antitumor effect determination. The CA did not significantly increase AST, ALT, TBIL, or ALB values (Table 5). These data suggest that CA does not injure the liver function of mice. To determine antitumor effects of CA, the mice were divided into six groups randomly, as described in the 'Materials and methods' section. Experimental results indicate that CA had a better antitumor effect than BCNU or CCNU. Additionally, CA significantly enhanced antitumor effects of BCNU and CCNU (Figure 4B,C). Moreover, the control group had much higher AST levels (1456.4 ± 360.6 IU/l) than other groups. The AST levels of the sham, CA, BCNU, CCNU, CA + BCUN, and CA + CCNU groups were (113.16 ± 24) IU/l, (180.1 ± 34.4) IU/l, (430.2 ± 102.5) IU/l, (657.8 ± 128.1) IU/l, (187.3 ± 60.3) IU/l, and (201.7 ± 88.8) IU/l, respectively. The AST values were significantly reduced in CA, CA + BCUN, and CA + CCNU treated groups. The ALT levels of the sham, control, CA, BCNU, CCNU, CA + BCUN, and CA + CCNU group were (20.3 ± 3) IU/l, (154.8 ± 17.8) IU/l, (42.45 ± 11.7) IU/l, (97 ± 58.7) IU/l, (72 ± 34) IU/l, (49.3 ± 20.2) IU/l, and (43.5 ± 18.5) IU/l, respectively (Figure 5). These data suggest that CA may be safe and useful for melanoma treatment in the future. In addition, CA may be suitable for BCNU or CCNU co-treatment in clinics.
CA is one of the main pharmacological compounds extracted from rosemary (R. officinalis). CA displays some biological functions, including antioxidant, anti-inflammatory, and anticancer [1–3]. Some previous studies have shown that CA inhibits cancer cell proliferation and migration [2,4–6]. CA arrests cell cycle at the G2 phase of human glioma cells [27]. p21 is a cyclin-dependent kinase inhibitor that triggers apoptosis, cell cycle arrest, and proliferative inhibition in response to many stimulations. p21 is regulated by p53, and plays important roles in inhibiting cyclin-dependent kinases such as CDK2, CDK3, CDK4, and CDK6, leading to G0/G1 cell cycle arrest [28,29]. However, p21 can also block the cell cycle at the G2/M phase through interaction with PCNA and CDK1 [30]. p27, which is a key tumor suppressor similar to p21, is another important cell cycle progression regulator. Down-regulation of both p21 and p27 expression in cancer cells result in more aggressive tumors [31]. p27 arrests the cell cycle at the G0/G1 phase by inhibiting CDK/cyclin complexes [32,33]. Both reduction and loss of p27 expression lead to cancer cell proliferation and increased invasiveness. The present study found that CA inhibited B16F10 cell survival, proliferation, colony formation and, wound healing activity (Figure 1). We also found that CA arrests B16F10 cells at the G0/G1 phase, and that the most effective dose of CA was 10 μM (Table 1). Additionally, CA increased p21 expression significantly in a dose-dependent manner. CA but decreased p27 expression while at treated doses over 10 μM (Figure 2), thus possibly explaining why CA had the strongest effect on the cell cycle at a concentration of 10 μM.
Melanoma, one of the most aggressive malignancies, exhibits low response rates of standard therapy, and has a constancy of poor prognosis. Combined treatment strategies are commonly used in clinics. For example, BCNU is administered alone or in combination with other drugs, including darcabazine and cisplatin. Another combined treatment in common use for melanoma is the CVD regimen, comprising BCNU, vinblastine, and dacarbazine [34]. CCNU is also used in the other combined strategy. For example, CCNU combined with bleomycin, vincristine, and dacarbazine (as a BOLD regimen) can be used to treat patients with metastatic uveal melanoma [35]. Taken together, BCNU and CCNU are suitable for combined therapy in clinics. The present study used B16F10 cells to set up a melanoma tumor xenograft model, and treated mice with CA, BCNU, CCNU, CA + BCNU, or CA + CCNU. The combined treatment of CA with BCNU or CCNU (CA + BCNU and CA + CCNU groups) was more effective than any single treatment by these drugs (Figure 3). These two combined strategies may be useful in future clinical applications.
Normally, AST can be detected in red blood cells, muscle, liver, heart and, other organs. Damaged tissues or organs cause AST to be released into the bloodstream. High plasma levels of AST can be directly detected. Therefore, AST can be used as an indicator of tissue damage. The other important liver enzyme is ALT, which is more specific for the liver than AST. The blood tests for AST and ALT are often performed at the same time. These blood tests are considered to be two of the most important tests to determine liver damage. The ratio of AST and ALT is used to distinguish liver injury from damage to the muscle, heart, or other organs. Most of liver disease cases have a ratio of AST/ALT less than 1. In contrast, heart or muscle injury generally has higher levels of AST than ALT, with a ratio of AST/ALT much greater than 1. In the present study, the average AST value in the control group was greater than 1000 IU/l, which was higher than in other treated groups (Table 4 and Figure 5A). Additionally, the tumor volume was found to be positively correlated with AST value. Melanoma tumor also caused the ALT value to increase. However, the ratio of AST/ALT of control group was much higher than 1 (Table 4 and Figure 5). These results indicate that the melanoma tumor may corrupt the muscle layer of mice, but does not damage liver harmfully. CA or combined treatments significantly decreased the AST value. These data indicate that CA may inhibit melanoma tumor growth and erosion, and enhance the antitumor effects of BCNU and CCNU. A biosafety test of CA was also performed in the present study. A single CA injection (50 mg/kg, injected peritoneally every day for 7 days) did not increase AST, ALT, TBIL, or ALB values significantly (Table 5). Even raising the injected CA dose to 100 mg/kg still did not cause obvious damage to the mice (data not shown), indicating that CA may be safe to use in both animal and human bodies.
In conclusion, CA inhibits melanoma cell growth and arrests cell cycle significantly. Additionally, CA inhibits melanoma tumor growth, and improves the anticancer effects of BCNU and CCNU in vitro and in vivo. Finally, the present study indicates that CA may be safe to use in future clinical trials.
Competing interests
The authors declare that there are no competing interests associated with the manuscript.
This work was supported in part by the Taiwan Ministry of Science and Technology [grant number MOST 105-2320-B-650-001]; the Chang Bing Show Chwan Memorial Hospital Research [grant number RD103025]; the E-Da Cancer Hospital Research [grant numbers ECPJ105002, EDCHT106015, EDCHT106002 and EDCHP106003]; and the National Key Clinical Discipline.
We thank the help from all institutions of all authors, including the Sixth Affiliated Hospital, Sun Yat-sen University, Chang Bing Show Chwan Memorial Hospital, E-Da Hospital, E-Da Cancer Hospital, I-Shou University, Fooyin University, and Kaohsiung Chang Gung Memorial Hospital.
Abbreviations: ALB, albumin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BCNU, carmustine; CA, carnosic acid; CCNU, lomustine; DMEM, Dulbecco's modified Eagle's medium; PI, propidium iodide; TBIL, total bilirubin
- © 2018 The Author(s).
This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).


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A defect in Oracle WebLogic is used in Cryptojacking campaigns
The newly discovered CVE-2019-2725 flaw in Oracle WebLogic, which received a patch a while ago, is still used in campaigns Cryptojacking, according to her security researchers Trend Micro.
It is about a zero day remote command execution vulnerability that affects the wls9_async and wls-wsat elements of Oracle Weblogic. All versions of Weblogic are susceptible to vulnerability, including the latter, which has wls9_async_response.war and wls-wsat.war enabled.
The error could be exploited by a hacker by sending a specially modified HTTP request.
While the CVE-2019-2725 bug was fixed at the end of April, a few days later, malware began using Oracle WebLogic Server vulnerability to spread the Sodinokibi ransomware.
Experts from the SANS Institute reported that the flaw was already being exploited by hackers to carry out Cryptojacking campaigns.
According to Trend Micro security experts, malware keeps its malicious code in certificate files in order to keep it hidden. Once the malware is installed in the system, it begins to exploit the error and initiates a series of chain attacks.
The attack starts with a PowerShell that downloads a certificate file from the C2 server. Malicious code uses the CertUtil tool to decode the file and then execute it using PowerShell. Then, the file you receive is deleted with cmd.
The certificate file appears as PEM (Privacy-Enhanced Mail).
The command in the certificate file is used by scammers to download and run another PowerShell script in memory. The script downloads and runs multiple files, such as Sysupdate.exe (Monero miner), Config.json (Miner configuration file), Networkservice.exe (probably used for WebLogic propagation and exploitation), Update.ps1 (PowerShell script for memory), Sysguard .exe (watchdog for mining process) and Clean.bat (deletes other items).
Experts found that the update.ps1 file containing the decoded certificate file is being replaced with the new update.ps1 and creating a scheduled task to run the new PowerShell script every 30 minutes.
Practical concealment of malicious code in certificates to prevent it from being traced is not new. Sophos has dealt with such a case in a test demonstration last year.
The author allows you to copy his / her text only if you report the source (SecNews.gr), as an e-mail address (Live URL) of the article.
Updated on by


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Mahindra is the only manufacturer in India which makes affordable electric cars. The e2o plus is the cheapest electric car that you can lay your hands on in India followed by the eVerito which is India's first all-electric sedan. Mahindra electric also makes the eSupro and the eAlfa Mini which are both all-electric commercial vehicles.
Mahindra electric confirmed that they will be launching another all-electric product by the FY 2019-20. Mahindra showcased the eKUV100 at the 2018 Indian Auto Expo and chances are very high that the proposed electric car will be the same. Pawan Goenka, Managing Director, M&M confirmed that the new electric SUV will be launched during 2019-2020 financial year, but no further details were revealed. The eKUV100 will be the first electric SUV in India when launched. Mahindra's spokesperson has also confirmed that the eKUV100 will be using a new powertrain setup which is different from the one in the e2o. The new powertrain should pack more range and performance to support the compact SUV's dimensions. The exterior design is very similar to the standard KUV100, but the car will feature tech like smartphone connectivity, remote diagnostics, cabin pre-cooling and real-time location tracking.
Many other manufacturers are also planning to join the EV bandwagon soon with competitive products. Hyundai, Maruti, and Tata is ahead of the others with product lineup planned for the coming years.
For latest auto news, new car hot deals, new car launches and car advise,follow mynewcar.in on Twitter and Facebook
Pic Source - AutoIndia


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A recent experience yanks me back to 2015. You know, because I had to pee. You probably know what that's like.
My Next Step with Mental Illness
The next step for me in my journey with Mental Illness. This is a tough one to swallow, but it's time, and my responsibility.
Today We Wait - Psychiatry in Puerto Rico
Flashbacks - Mania, Anxiety and Depression
Mother Nature Renews, People are Strong
We Got Lucky - And a Little Learning
A little before and a little after the storm - Hurricane Irma - A couple thoughts and a short video.


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Gordon Rafool
Stephens County High Class of 1960
Personal Info
- Name:
- Gordon Rafool
- Graduation Year:
- 1960
Register to view Current location, Gender, Birthday, Relationship Status, Children, Employer, Military, College, and Interests
Memories of Gordon Rafool
What I'm doing now:Register to see what Gordon Rafool is up to now!
Gordon Rafool's Latest Activity:
|- Updated his profile. January
|- Updated his profile picture. 2015
|- Registered as a SCHS Class of 1960 alumni. 2015
|- Added photos to their personal photo gallery. 2015


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Grade 4
Home to Me
When i am home i feel safe, loved, cared about and warm. Every two hours I give my brothers a hug. My mom and dad are funny and that makes my life weird. My bed is comfortable and even the couches are comfortable. Mostly the house floor is made out of brown hardwood. Our living room table is made of black stone I think. The walls are tan. In the basement, the floor is mostly stone. My family and I have been having some problems with the front door it hasn't been opening very well but I am fine with it. My house has been changing, we have been moving the furniture around the house. I have my dads old bresser my brother and i have to share a room and a bunk bed. Home is a good place to me because when my family and I move to a new house it does not feel right. That is why home is a good place to me.


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James Bond might drive an electrical Aston Martin within the & # 39; Bond 25 & # 39;
Is James Bond about to go inexperienced in Bond 25? He may be. Daniel Craig might doubtlessly drive the Aston Martin Rapide E electrical in Cary Joji Fukunaga's upcoming movie, in line with a report from the UK's The Solar.
'Bond 25': All you have to learn about Daniel Craig's upcoming James Bond film
In response to the report, an insider near the manufacturing mentioned that "the choice was made by the brand new director of the movie, which is completely heroic.It really works immediately with Aston Martin to arrange one in all their vehicles for its close-up. "
When it was first introduced in 2017, Aston Martin wrote in a press launch that the mannequin would have "a manufacturing restricted to 155 vehicles." The automobile, which is Aston Martin's first electrical automobile, will go into manufacturing later in 2019. and can price £ 250,000 (about 332,000 USD in US dollars), in line with Automotive and Driver.
The Solar's supply went on to claim that the automobile could be utilized in an "unbelievable sequence of motion" within the movie. There can be all of the excessive tech devices. To be clear, Cary insisted that Daniel and the producers embark on the journey. In response to latest data, a manufacturing is about up in Italy to movie the motion sequence of the movie, though there is no such thing as a affirmation but that this scene can be one to current the movie. Aston Martin Rapide E.
Who would be the subsequent James Bond after Daniel Craig?
Greg Williams / Eon Productions through Getty Photos
The electrical mannequin of Aston Martin can have an "800V battery electrical structure with an put in capability of 65 kWh" and may have "a charging price 1851.2 miles ". per hour with a typical charger of 400 V, 50 kW, "in line with the Aston Martin web site.
Bond's subsequent movie is scheduled for launch in April 2020, after many delays as a consequence of Danny Boyle's change of administrators in Fukunaga, in addition to new work on Scott Z's screenplay. Burns (The Report, The Bourne Ultimatum ). Fukunaga, who has directed all the season's first True Detective and the unbelievable scene of episode four, takes the largest manufacturing of his profession in Bond 25 after engaged on smaller movies equivalent to Sin Quantity, Jane Eyre and Beasts. From no nation.
Assembly with the brand new director of the subsequent James Bond Movie by Daniel Craig
Bond 25 can be launched on April eight, 2020.


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Heimo Brandstatter
Verde River Golf & Social Club
Rio Verde, AZ
It's been a while since the Valley golf scene has had so much new to crow about. Following the national trend, investment in golf projects has been limited in Arizona. The 2015 debut of Wickenburg Ranch Golf & Social Club received national acclaim, but otherwise it's been fairly quiet with regards to new golf courses or major renovations.
That's all about to change. Beginning this fall, golf operators in the Valley will unveil a number of new courses and substantial renovations. These will include some impressive updates to the highly ranked Cholla Course at We-Ko-Pa Golf Club; the opening of a new golf course at Victory at Verrado; and renovations to Tonto Verde's Peaks Course, Sun Lakes' Ironwood Country Club, historic Mountain Shadows, and my own Verde River Golf & Social Club.
Staying particularly busy are Tom Lehman and his partner Chris Brands of Lehman Design Group, as they are handling what are the two most substantial new projects on that list – the Victory course at Verrado and Verde River's significant transformation. Both courses are expected to open later this year. Lehman was the logical choice for both of these projects. He designed the original Verrado Course, which was named a "Top 10 Best New" by GOLF Magazine. And, he was also the designer of Shea Homes' Encanterra Country Club in San Tan Valley, which has been chosen among the top private clubs in the nation by GOLF Magazine, Golfweek, and LINKS Magazine (Shea Homes is also spearheading the Verde River project). These new courses complement Lehman's previous Valley work at DC Ranch, Phoenix Country Club and The Wigwam Gold Course.
Despite what some have reported, the golf market in Arizona has never been stronger. The demand for the Valley as an international destination of choice continues to grow, and the more responsible expansion of supply means each facility can operate as a healthy, stand-alone business. This steadying trend means that locals will continue to be spoiled by the amazing weather, breathtaking designs, and near-perfect golf conditions for which our region is known.
The peak winter season is just around the corner, so get ready now to visit all the new and established courses our area has to offer. And if you're feeling really adventurous, do the "edge-to-edge" Lehman tour and check out Victory at Verrado in the west and Verde River Golf & Social Club in the east.
Heimo Brandstatter is the General Manager at Verde River Golf & Social Club, the centerpiece to Shea Homes' exciting new Trilogy at Verde River master-planned, resort-style community. Learn more about Heimo and Trilogy at www.trilogylife.com.


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WEST KELOWNA B.C. – The West Kelowna Warriors fall to the Vernon Vipers by a score of 6-3 Friday night.
The Warriors have struggled to score first this season but it only took them 56 seconds to score the opening goal of the game. Wyatt Head was able to feed Cavin Tilsley with a slap pass to give the Warriors a 1-0 lead. Only 2 minutes later the Vipers would answer back with a quick goal from their veteran Josh Latta to tie the game. The Vipers would continue to pressure the Warriors which led to Brendan Kim to score his first BCHL goal and the Vipers took a 2-1 lead. The Warriors would respond in the last few minutes of the first period with a goal from Willie Reim assisted by Chase Dubois and Austin Chorney. The Vipers would regain the lead only 24 seconds later when Josh Latta would get hauled down on a breakaway which looked to be a penalty shot upcoming but Warriors goaltender Brock Baier noticed the puck wasn't touched by a Warriors player and it went in before a Warrior player was able to touch the puck. It was a bit of a disastrous sequence for the Warriors that they wish they had back going into the 2nd period.
The turning point of the game had to be in the second period where the Vipers killed a power play to start the game allowing them to gain momentum and more pressure in the Warriors end allowing for former West Kelowna Warrior Matt Kowalski to score against his former club. Things began to fall apart for the Warriors with mistakes in their own end leading to Garrett Worth scoring his first BCHL goal only a minute later forcing Brock Baier out of his net for the second straight game.
In the third the Warriors would once again start the period on the man advantage but wouldn't be able to capitalize. Viper goaltender Aiden Porter made numerous quality saves and the Vipers would take advantage of another Warriors turnover in their own zone leading to Brendan Kim scoring his second of the night giving the Vipers a 6-2 lead. Bennett Norlin would score his 10th of the season short handed but in the end it was too late.
Shots on goal 37-34 in favor of the Warriors.
3 Stars
- VER D Brendan Kim (2G)
- VER F Josh Latta (2G)
- VER F Matt Kowalski (1G-1A)


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Dogfight Friday November 1 2019 at 7:30 PM
You've selected
Friday November 1 2019
Change Date
× Based on the 1991 film, this musical follows a young soldier as he looks for a last minute date to a party. Enter kind, simple and trusting Rose and what starts out as a cruel invitation ends in a timeless lesson of love and compassion. THIS SHOW IS INTENDED FOR MATURE AUDIENCES ONLY
Main Theater
2411 E Irlo Bronson Memorial Hwy
Kissimmee FL 34744


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You Were Made for More
We had the pleasure of talking with Brian Green and Skyler Schissler. We discussed topics like defining success, taking responsibility, and getting your team to play on their strengths. It was a pleasure to have these two share their stories and learn what they're passionate about.


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Flexible HVDC transmission systems small signal modelling: a case study on CIGRE Test MT-HVDC grid
Document typeConference report
Date issued2017
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Rights accessOpen Access
Future Flexible HVDC Transmission Systems will consist of several active and passive infrastructures including DC Power Flow Controller (DC-PFC) device. The addition of the DC-PFC to the future Multi-Terminal HVDC (MT-HVDC) grids arises some key concerns such as stability, system interoperability, and possible adverse interactions. Hence, a suitable model is necessary to conduct deep frequency domain analysis. In this context, this paper proposes a linearized model for small-signal stability analysis of flexible MT-HVDC grids in state space framework that can be straightforwardly utilized in the process of control design. In this paper, a spick-and-span, systematic and step-by-step process to derive the small signal model of all flexible MT-HVDC grid components is presented such that each sub-system is modeled individually and then all are integrated together. The derived model is cross-verified by time domain simulations of a nonlinear system model in a MATLAB/SIMULINK platform for CIGRE DCS3 MT-HVDC test grid.
CitationHeidary Yazdi, S., Rouzbehi, K., Candela, J., Milimonfared, J., Rodriguez, P. Flexible HVDC transmission systems small signal modelling: a case study on CIGRE Test MT-HVDC grid. A: Annual Conference of the IEEE Industrial Electronics Society. "IECON 2017: 43rd IEEE Annual Conference of the IEEE Industrial Electronics Society: China National Convention Center, Beijing, China, 29, October-01 November, 2017: proceedings". Institute of Electrical and Electronics Engineers (IEEE), 2017, p. 256-262.
|Flexible+HVDC+T ... MT-HVDC+Grid_postprint.pdf