text:
The Dual Amylin and Calcitonin Receptor Agonist KBP-088 Induces Weight Loss and Improves Insulin Sensitivity Superior to Chronic Amylin Therapy
KBP-088 (KeyBiosciencePeptide 088) is a potent dual amylin and calcitonin receptor agonist (DACRA). DACRAs are known to elicit potent activity in terms of typical amylin-induced responses, such as reducing food intake and body weight. However, to what extent amylin infusion can mimic the effects of …
- Larsen AT,
- Sonne N,
- Andreassen KV,
- Gehring K,
- Karsdal MA,
- Henriksen K,
Use of Plasma Fragments of Propeptides of Type III, V, and VI Procollagen for the Detection of Liver Fibrosis in Type 2 Diabetes
This study assessed the utility of plasma fragments of propeptides of type III (PRO-C3), V (PRO-C5), and VI (PRO-C6) procollagen for the detection of liver fibrosis in patients with type 2 diabetes mellitus (T2DM).
Patients with T2DM (n = 191) underwent a…
- Bril F,
- Leeming DJ,
- Karsdal MA,
- Kalavalapalli S,
- Darb D,
- Lai J,
- Rabe M,
- Cusi K,
Incidence of total hip and total knee replacements from the prospective epidemiologic risk factor study: considerations for event driven clinical trial design
Osteoarthritis (OA) leads to joint failure and total joint replacement (TJR, either hip (H) or knee (K)). Worsening of pain and joint space narrowing are believed to be surrogates for joint failure; however, we hypothesize that TJR, as a reflection of joint failure, can be used as an en…
Hematopoietic stem cell-targeted neonatal gene therapy with a clinically applicable lentiviral vector corrects osteopetrosis in oc/oc mice.
Infantile malignant osteopetrosis (IMO) is an autosomal recessive disorder characterized by nonfunctional osteoclasts. Approximately 50% of the patients have mutations in the TCIRG1 gene, encoding for a subunit of the osteoclast proton pump. Gene therapy represents a potential alternative treatment …
- Löfvall H,
- Rothe M,
- Schambach A,
- Henriksen K,
- Richter J,
- Moscatelli I,
A dual amylin and calcitonin receptor agonist inhibits pain behavior and reduces cartilage pathology in an osteoarthritis rat model
Pain and disability are the main clinical manifestations of osteoarthritis, for which only symptomatic therapies are available. Hence, there is a need for therapies that can simultaneously alter disease progression and provide pain relief. KBP is a dual amylin- and calcitonin-receptor a…
- Katri A,
- Dabrowska A,
- Lövfall H,
- Karsdal MA,
- Andreassen KV,
- Thudium CS,
- Henriksen K,
Serological Assessment of the Quality of Wound Healing Processes in Crohn's Disease.
Crohn's disease (CD) is a chronic inflammatory condition characterized by continuous mucosal damage and ongoing wound healing of the intestines. The fibrinolytic system is involved in early parts of the wound healing process. Fibrin is a key mediator of primary blood clot forma…
- Sun S,
- Karsdal MA,
- Mortensen JH,
- Luo Y,
- Kjeldsen J,
- Krag A,
- Jensen MD,
- Bay-Jensen AC,
- Manon-Jensen T,
Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest
Background: Anoxic brain injury is the primary cause of death after resuscitation from out-of-hospital cardiac arrest (OHCA) and prognostication is challenging. The aim of this study was to evaluate the potential of two fragments of tau as serum biomarkers for neurological outcome.
Methods: Sing…
- Grand J,
- Kjaergaard J,
- Nielsen N,
- Friberg H,
- Crongerg T,
- Bro-Jeppesen J,
- Karsdal MA,
- Nielsen HB,
- Frydland M,
- Henriksen K,
- Matsson N,
- Zetterberg H,
- Hassager C,
Low bone turnover levels predict increased risk of cancer
Several epidemiological studies have shown an association between bone mineral density (BMD) and risk of breast cancer in postmenopausal women, but it remains unknown whether bone turnover is associated with increased risk of cancer. The aim of this study was to investigate if markers o…
- Bager CL,
- Bay F,
- Christiansen C,
- Karsdal MA,
Circulating Biomarkers of Testosterone's Anabolic Effects on Fat-Free Mass
Biomarkers that predict response to anabolic therapies could expedite the development of function promoting anabolic drugs. This study aimed to identify serum biomarkers that are responsive to testosterone administration and associated with increases in fat-free mass (FFM).
- Huang G,
- Rocha GV,
- Pencina KM,
- Cox K,
- Krishnan V,
- Henriksen K,
- Mitchell P,
- Sissons SE,
- Li Z,
- Nedergaard AF,
- Karsdal MA,
- Sun S,
- Storer TW,
- Basaria S,
- Bhasin S,
Matrix Metalloprotease Generated Fragments of Type VI Collagen Have Serum Biomarker Potential in Cancer - A Proof of Concept Study
Type VI collagen (COL6) is associated with several pro-tumorigenic events. COL6 is primarily composed of three alpha-chains (a1-a3) forming a specialized microfibrillar network to support tissue architecture. COL6 homeostasis is lost in the tumor due to increased COL6 synthesis by activ…
- Willumsen N,
- Karsdal MA,
- Bager C,
Cancer risk in relation to body fat distribution, evaluated by DXA-scans, in postmenopausal women - the Prospective Epidemiological Risk Factor (PERF) study
Studies with direct measures of body fat distribution are required to explore the association between central and general obesity to cancer risk in postmenopausal women. This study investigates the association between central obesity and general obesity to overall/site-specific cancer risk in postme…
- Stanstrup LM,
- Nielsen HB,
- Pedersen BK,
- Karsdal MA,
- Blair JPM,
- Christensen JF,
- Bager CL,
Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort
Chronic obstructive pulmonary disease (COPD) is characterized by a slow heterogeneous progression. Therefore, improved biomarkers that can accurately identify patients with the highest likelihood of progression and therefore the ability to benefit from a given treatment, are needed. Elastin is an es…
- Ronnow SR,
- Langholm LL,
- Sand JMB,
- Thoracius-Ussing J,
- Leeming DJ,
- Manon-Jensen T,
- Tal-Singer R,
- Miller BE,
- Karsdal MA,
- Vestbo J,
Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology
The extracellular matrix (ECM) plays an important role in cancer progression. It can be divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior and the interstitial matrix (IM) that supports the underlying stromal compartment. The major components of the ECM are th…
- Nissen N,
- Karsdal MA,
- Willumsen N,
Biochemical and histological characterisation of an experimental rodent model of non-alcoholic steatohepatitis - Effects of a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist and a glucagon-like peptide-1 analogue
Non-alcoholic steatohepatitis (NASH) is a prevalent disease that is highly associated with the metabolic syndrome and type II diabetes. The development of in vivo models that reflect all nuances of the human NASH pathology is essential for drug discovery and development. We aimed to fur…
- Daniels SJ,
- Leeming DJ,
- Detlefsen S,
- Bruun MF,
- Hjuler ST,
- Henriksen K,
- Hein P,
- Karsdal MA,
- Brockbank S,
- Cruwys S,
Association of metabolites reflecting type III and VI collagen formation with modified Rodnan skin score in systemic sclerosis - a cross-sectional study
The objective was to investigate blood-based biomarkers of type I (PRO-C1), III (PRO-C3) and VI (PRO-C6) collagen formation in systemic sclerosis (SSc) patients and examine their correlation to modified Rodnan skin score (mRSS).
Limited (lSSc, n = 76) and diffuse SSc (dSSc, …
- Juhl P,
- Vinderslev Iversen L,
- Karlsmark T,
- Karsdal MA,
- Bay-Jensen AC,
- Mogensen M,
- Siebuhr AS,
GPDPLQ1237-A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro
C-telopeptide of type II collagen (CTX-II) has been shown to be a highly relevant biomarker of cartilage degradation in human rheumatic diseases, if measured in synovial fluid or urine. However, serum or plasma CTX-II have not been demonstrated to have any clinical utility to date. Here, we describe…
- Löfvall H,
- Katri A,
- Dabrowska A,
- Karsdal MA,
- Luo Y,
- He Y,
- Manon-Jensen T,
- Dziegiel MH,
- Bay-Jensen AC,
- Thudium CS,
- Henriksen K,
Combining Naproxen and a Dual Amylin and Calcitonin Receptor Agonist improves pain and structural outcomes in the Collagen-Induced Arthritis rat model
Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not disease-modifying and do not prevent joint destruction w…
- Katri A,
- Dabrowska A,
- Löfvall H,
- Ding M,
- Karsdal MA,
- Andreassen KV,
- Schneider Thudium C,
- Henriksen K,
Enhanced processing of von Willebrand factor reflects disease severity and discriminates severe portal hypertension in cirrhosis
Portal hypertension in cirrhosis is associated with endothelial dysfunction, impaired wound healing, and decreased platelet count. Increased von Willebrand factor (VWF) formation has been suggested as a compensatory mechanism, but the role of VWF processing has not been directly assesse…
- Langholm LL,
- Manon-Jensen T,
- Karsdal MA,
- Bendtsen F,
- Leeming DJ,
- Møller S,
Serological Assessment of Activated Fibroblasts by alpha-Smooth Muscle Actin (α-SMA): A Noninvasive Biomarker of Activated Fibroblasts in Lung Disorders
Remodeling of the extracellular matrix (ECM) is a key event in different lung disorders, such as fibrosis and cancer. The most common cell type in the connective tissue is fibroblasts, which transdifferentiate into myofibroblasts upon activation. All myofibroblasts express α-SMA, which …
- Holm Nielsen S,
- Willumsen N,
- Leeming DJ,
- Daniels SJ,
- brix s,
- Karsdal MA,
- Genovese F,
- Nielsen MJ,
Metabolites of C-reactive protein and vimentin are associated with disease activity of axial spondyloarthritis.
Non-radiographic (nr-axSpA) and radiographic (AS) forms of axial spondyloarthritis (axSpA) share clinical features, but have different radiographic patterns. Radiographic progression is not associated with the current disease activity biomarkers. We investigated a matrix metalloproteina…
- Siebuhr AS,
- Husakova M,
- forejtová S,
- Zegzulkova K,
- Tomcik M,
- Urbanova M,
- Grobelna K,
- Gatterova J,
- Bay-Jensen AC,
- Pavelka K,
Collagen type IV remodelling gender-specifically predicts mortality in decompensated cirrhosis
Remodelling of extracellular matrix is crucial in progressive liver fibrosis. Collagen type III desposition has been shown in acute decompensation. Extratracellular matrix is compiled of deposition of various components. The role of basement membrane collagen type IV in advanced …
- Lehmann J,
- Praktiknjo M,
- Nielsen MJ,
- Schierwagen R,
- Meyer C,
- Thomas D,
- Violi F,
- Strassburg CP,
- Bendtsen F,
- Møller S,
- Krag A,
- Karsdal M,
- Leeming DJ,
- Trebicka J,
Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development
This review focuses on the molecular taxonomy of osteoarthritis from the perspective of molecular biomarkers. We discuss how wet biochemical markers may be used to understand disease pathogenesis and progression and define molecular endotypes of osteoarthritis and how these corre…
- mobasheri A,
- Van Spil WE,
- Budd E,
- Uzieliene I,
- Bernotiene E,
- Bay-Jensen AC,
- Larkin J,
- Levesque MC,
- Gualillo O,
- Henrotin Y,
Potential diagnostic value of a type X collagen neo-epitope biomarker for knee osteoarthritis.
Phenotypic changes of chondrocytes toward hypertrophy might be fundamental in the pathogenesis of OA, of which type X collagen (Col10) is a well-known marker. The purpose was to develop a specific immunoassay for blood quantification of a newly identified neo-epitope of type X collagen t…
- He Y,
- Manon-Jensen T,
- Arendt-Nielsen L,
- Petersen KK,
- Christiansen T,
- Samuels J,
- Abramson S,
- Karsdal MA,
- Attur M,
- Bay-Jensen AC,
Vastatin (the NC1 domain of human type VIII collagen a1 chain) is linked to stromal reactivity and elevated in serum from patients with colorectal cancer.
Vastatin, a fragment derived from type VIII collagen, is one of the least studied collagen-derived matrikines. Vastatin can be detected in serum but little is known regarding the relevance of serum vastatin in colorectal cancer (CRC). In this study, serum vastatin was measured (ELISA) in 67 healthy …
- will,
- Jorgensen LN,
- Karsdal MA,
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.
Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/mTOR axis has been implicated in fibrosis, with pan-PI3K/mTOR inhibition currently under clinical evaluatio…
- Woodcock HV,
- Eley JD,
- Platé M,
- Manthakumar CB,
- Martufi M,
- Peace S,
- Joberty G,
- Poeckel D,
- Good RB,
- Taylor AR,
- Zinn N,
- Redding M,
- Forty EJ,
- Hynds RE,
- Santon C,
- Karsdal MA,
- Maher TM,
- Bergamini G,
- Marshall RP,
- Blanchard AD,
- Mercer PF,
- Chambers RC,


text:
Equine America Mouth & Bit Balm will moisturise and protect dry areas of your horse's mouth. It provides acceptance and comfort of the bit, supporting performance training and helping to achieve a more responsive and happier horse – as well as helping young horses to mouth.
- 100% natural
- Antibacterial
- Antifungal
- Contains premium grade butters, essential oils and waxes
- Highly-palatable natural ingredients
Made from a complex blend of eleven natural ingredients which have been chosen for their ability to support the health, suppleness and softness of your horse's mouth:
- Abyssinian oil – contains a unique structure to provide skin with deep nourishment to support smoothness and elasticity, and is easily absorbed into the epidermal tissue
- Avocado oil – packed full of vitamins A, B, D and E, protein and lecithin. Protects and supports sensitive skin
- Beeswax – a naturally nourishing moisturiser which softens the skin. Creates a long lasting barrier against the elements. Contains antibacterial properties
- Coconut oil – has skin softening antibacterial and antifungal properties. Closely resembling skin sebum, it assists hydration of the skin and suppleness
- Grape seed oil – shown to have strong antioxidant and moisturising benefits to the skin by supporting collagen and elastin. Contains linoleic acid which supports healthy cell membranes
- Jojoba oil – has exceptional skin softening, antibacterial and antifungal properties. Closely resembling skin sebum, it prevents dehydration of the skin and can increase suppleness by up to 45%
- Kukui nut oil – valued for its soothing effects. Easily absorbed by the deepest layers of the skin. Forms a protective barrier, so is excellent for dry skin. Contains vitamins A, C, E and F and essential fatty acids (EFAs)
- Mango butter – a highly soothing, softening and moisturising butter. A rich source of antioxidants and vitamins A, C and E. Promotes healthy skin and helps shield against harmful UV rays
- Moringa seed oil – high in antioxidants and vitamins A, B, C and E, which support and protect overall skin health
- Peppermint oil – contains numerous vitamins and minerals including manganese, iron, magnesium, calcium, potassium, copper and vitamins A and C. Has a cooling effect, reducing skin irritations
- Shea butter – an excellent moisturiser for the skin. Rich in essential fatty acids (EFAs), phytosterols and vitamins A, D and E. Supports the skin by stimulating collagen production

subset: commoncrawl


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Smart lighting
In the US, outdoor lighting uses about 120 terawatt-hours of energy, mostly to illuminate streets and parking lots. IDA estimates that least 30% of all outdoor lighting in the US alone is wasted, mostly by lights that aren't shielded. That adds up to $3.3 billion and the release of 21 million tons of carbon dioxide per year. To offset all that carbon dioxide, we'd have to plant 875 million trees annually.
Smart lighting has the huge potential to save cities millions of dollars and reduce carbon emissions. The installation of smart lighting projects are able cut energy use in cities by up to 70%. LED street lighting enhanced with smart technology such as automated dimmers, motion sensors and timers can further reduce energy costs. Smart lighting systems can be controlled using the internet to adjust lighting brightness and schedules.
Smart Lighting Tutorials
Smart LED Dimming Solution
Smart LED Dimming Solution using Intel Galileo board, photoresistor and PIR motion sensor. Tutorial by Arman Hasanbegovic and Kemal Korjenic.
Smart Lighting Discussion
World Air Quality Map and forecast
The rise of LEDs and what it means for cities
How to Select Solar Street Lighting


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Tag: virtual reality
Virtual reality research at WID is focused on advancing the field of virtual reality, ranging from creating novel and natural interfaces for immersive virtual environments to developing methods, techniques, and tools to better understand, evaluate, and develop interactive virtual experiences. The challenges and benefits of this research span across many disciplines.
Virtual reality researchers engage in projects with departments such as Industrial and Systems Engineering, Design Studies, Library and Information Studies, Nursing, Art, Dance as well as projects in Digital Humanities.
Virtual reality is a key component of WID's Data Science Hub.
Lexi Soto
Andrew Liu
Kudirat Alimi
My work consists of completing a variety of administrative tasks that promote the VE Lab's projects.
Christopher Thorstenson
Dongxia Wu
Bryce Sprecher
Acquire, process, interpret, and display spatial data for education, insight, and experience.
WID Hubs Launch at Illuminating Connections Event
WID's new hubs—Data Science, Multi-Omics, and Illuminating Discovery—represent a new path forward for collaborative research projects and fields.
Cap Times Q&A: Kevin Ponto Wants to Use Virtual Reality to Solve Real-world Problems
For WID's Kevin Ponto, virtual reality is more than a way of playing video games or simulating roller coaster rides. He thinks VR can be a tool for solving real-world problems.
Marin Murack
Melissa Schoenlein
Role of perceptual features (e.g. color) in cognitive processing and information visualization
Benny Wysong-Grass
Andreas Velten
Catalysts for Science Policy Group Finds New Home at WID, Focuses on Forensic Science Policy
CaSP is joining with the Wisconsin Institute for Discovery to amplify its voice on science policy issues. On October 4 in the Discovery Building, they host a panel on improving forensic science policy.
Project: A Virtual Tour Through Mount Horeb Area History
Robert Radwin
Virtual Environments Group
The LEL is a space and a place where scholars explore the connections among environment, technology, human action, experience, and visualization, with expertise in virtual and augmented reality.
Schloss Visual Perception and Cognition Lab
Investigating how observers make predictions about objects and entities based on their cognitive and emotional responses to perceptual information; focusing on how people's associations with colors influence cognitive processing in aesthetic response, judgment and decision making, and interpretation of information visualizations.
Ponto Lab
Develop techniques to better the experience of virtual reality through new devices, interfaces, and techniques.
Project: Exploring the Universe from Antarctica
LEL Videos
A day in the life of WID – check out our systems programmer, Ross Tredinnick, navigating a real home environment in the CAVE around 0:28 minutes. Note: the video above does not have any sound.
Alex Peer
Karen Schloss
Assistant Professor
Visual perception and cognition in information visualization and virtual reality.


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There are lots of benefits of studying for a degree, but it doesn't have to mean going to university. If you want to continue in education, progress in your career or move into a new career, a higher education (HE) course could be the perfect next step. With full and part-time options available, and a wide range of subjects, we're sure to have a course to meet your needs.
Our Foundation degree (FdA) courses are validated by the University of Bedfordshire.
Our HNC and HND courses are validated by Pearson.
Find the right course, at the right level, to help you achieve your best.
University of Bedfordshire courses
See a list of the courses validated by the University of Bedfordshire.
Why study higher education at Barnfield College?
- Save money by studying local and living at home
- Pay up to £6,165 a year compared to £9,000 at university
- Get yourself work-ready with our employer-focused curriculum
- Study in our purpose-built HE centre complete with lecture theatre, classrooms and social area
- Taught by highly qualified staff with extensive academic and industry knowledge
- Supportive environment with smaller class sizes and more one-to-one tutor contact
- Excellent value for money
- Choice of 'topping up' to a full Bachelors degree at a participating university or going directly into employment
Higher Education course validation
Our Foundation degree (FdA) courses are validated by the University of Bedfordshire.
Our HNC and HND courses are validated by Pearson.
QAA – the mark of HE quality
The Quality Assurance Agency for Higher Education (QAA) has confirmed the quality and standard have been met. As well as being recognised for meeting UK expectations, areas of good practice identified by QAA have been appropriately disseminated.
For more information
For more information or an informal discussion about our higher education programmes, please contact email@example.com, call us on 01582 569 569 or attend one of our Open Events.
Craig's Story
A journey toward a woodworking career.
Hear what Craig has to say about the support received and what he's learnt so far.
Chikesirum's Story
Chikesirum wants to be a Social Worker. Find out how she is getting on.
Alex's Story
Find out why Alex chose a course at Barnfield College to help him realise his aspiration of becoming a Chef
We know choosing what and where to study is a big decision. Here are a few big reasons why studying at Barnfield College could be the best choice for your future.


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Search Results
You are looking at 1 - 6 of 6 items for
- Author or Editor: Georg Widhalm x
- By Author: Millesi, Matthias x
Govindaraju Lakshmi Prasad
Matthias Millesi, Barbara Kiesel, Mario Mischkulnig, Mauricio Martínez-Moreno, Adelheid Wöhrer, Stefan Wolfsberger, Engelbert Knosp and Georg Widhalm
One of the most important causes for recurrence of intracranial meningiomas is residual tumor tissue that remains despite assumed complete resection. Recently, intraoperative visualization of meningioma tissue by 5-aminolevulinic acid (5-ALA)–induced protoporphyrin IX (PpIX) fluorescence was reported. The aim of this study was to investigate the possible surgical benefits of PpIX fluorescence for detection of meningioma tissue.
5-ALA was administered preoperatively to 190 patients undergoing resection of 204 intracranial meningiomas. The meningiomas' PpIX fluorescence status, fluorescence quality (strong or vague), and intratumoral fluorescence homogeneity were investigated during surgery. Additionally, specific sites, including the dural tail, tumor-infiltrated bone flap, adjacent cortex, and potential satellite lesions, were analyzed for PpIX fluorescence in selected cases.
PpIX fluorescence was observed in 185 (91%) of 204 meningiomas. In the subgroup of sphenoorbital meningiomas (12 of 204 cases), the dural part showed visible PpIX fluorescence in 9 cases (75%), whereas the bony part did not show any PpIX fluorescence in 10 cases (83%). Of all fluorescing meningiomas, 168 (91%) showed strong PpIX fluorescence. Typically, most meningiomas demonstrated homogeneous fluorescence (75% of cases). No PpIX fluorescence was observed in any of the investigated 89 dural tails. In contrast, satellite lesions could be identified through PpIX fluorescence in 7 cases. Furthermore, tumor-infiltrated bone flaps could be visualized by PpIX fluorescence in all 13 cases. Notably, PpIX fluorescence was also present in the adjacent cortex in 20 (25%) of 80 analyzed cases.
The authors' data from this largest patient cohort to date indicate that PpIX fluorescence enables intraoperatively visualization of most intracranial meningiomas and allows identification of residual tumor tissue at specific sites. Thus, intraoperative detection of residual meningioma tissue by PpIX fluorescence might in future reduce the risk of recurrence.
Matthias Millesi, Barbara Kiesel, Adelheid Woehrer, Johannes A. Hainfellner, Klaus Novak, Mauricio Martínez-Moreno, Stefan Wolfsberger, Engelbert Knosp and Georg Widhalm
Subtotal resection (STR) of spinal tumors can result in tumor recurrence. Currently, no clinically reliable marker is available for intraoperative visualization of spinal tumor tissue. Protoporphyrin IX (PpIX) fluorescence induced by 5-aminolevulinic acid (5-ALA) is capable of visualizing malignant gliomas. Fluorescence-guided resections of malignant cerebral gliomas using 5-ALA have resulted in an increased rate of complete tumor removal. Recently, the application of 5-ALA has also been described in the first cases of spinal tumors. Therefore, the aim of this observational study was to systematically investigate 5-ALA–induced fluorescence characteristics in different spinal tumor entities.
Three hours before the induction of anesthesia, 5-ALA was administered to patients with different intra- and extradural spinal tumors. In all patients a neurosurgical resection or biopsy of the spinal tumor was performed under conventional white-light microscopy. During each surgery, the presence of PpIX fluorescence was additionally assessed using a modified neurosurgical microscope. At the end of an assumed gross-total resection (GTR) under white-light microscopy, a final inspection of the surgical cavity of fluorescing intramedullary tumors was performed to look for any remaining fluorescing foci. Histopathological tumor diagnosis was established according to the current WHO classification.
Fifty-two patients with 55 spinal tumors were included in this study. Resection was performed in 50 of 55 cases, whereas 5 of 55 cases underwent biopsy. Gross-total resection was achieved in 37 cases, STR in 5, and partial resection in 8 cases. Protoporphyrin IX fluorescence was visible in 30 (55%) of 55 cases, but not in 25 (45%) of 55 cases. Positive PpIX fluorescence was mainly detected in ependymomas (12 of 12), meningiomas (12 of 12), hemangiopericytomas (3 of 3), and in drop metastases of primary CNS tumors (2 of 2). In contrast, none of the neurinomas (8 of 8), carcinoma metastases (5 of 5), and primary spinal gliomas (3 of 3; 1 pilocytic astrocytoma, 1 WHO Grade II astrocytoma, 1 WHO Grade III anaplastic oligoastrocytoma) revealed PpIX fluorescence. It is notable that residual fluorescing tumor foci were detected and subsequently resected in 4 of 8 intramedullary ependymomas despite assumed GTR under white-light microscopy.
In this study, 5-ALA–PpIX fluorescence was observed in spinal tumors, especially ependymomas, meningiomas, hemangiopericytomas, and drop metastases of primary CNS tumors. In cases of intramedullary tumors, 5-ALA–induced PpIX fluorescence is a useful tool for the detection of potential residual tumor foci.
Barbara Kiesel, Matthias Millesi, Adelheid Woehrer, Julia Furtner, Anahita Bavand, Thomas Roetzer, Mario Mischkulnig, Stefan Wolfsberger, Matthias Preusser, Engelbert Knosp and Georg Widhalm
Stereotactic needle biopsies are usually performed for histopathological confirmation of intracranial lymphomas to guide adequate treatment. During biopsy, intraoperative histopathology is an effective tool to avoid acquisition of nondiagnostic samples. In the last years, 5-aminolevulinic acid (5-ALA)–induced fluorescence has been increasingly used for visualization of diagnostic brain tumor tissue during stereotactic biopsies. Recently, visible fluorescence was reported in the first cases of intracranial lymphomas as well. The aim of this study is thus to investigate the technical and clinical utility of 5-ALA–induced fluorescence in a large series of stereotactic biopsies for intracranial lymphoma.
This prospective study recruited adult patients who underwent frameless stereotactic needle biopsy for a radiologically suspected intracranial lymphoma after oral 5-ALA administration. During biopsy, samples from the tumor region were collected for histopathological analysis, and presence of fluorescence (strong, vague, or no fluorescence) was assessed with a modified neurosurgical microscope. In tumors with available biopsy samples from at least 2 different regions the intratumoral fluorescence homogeneity was additionally investigated. Furthermore, the influence of potential preoperative corticosteroid treatment or immunosuppression on fluorescence was analyzed. Histopathological tumor diagnosis was established and all collected biopsy samples were screened for diagnostic lymphoma tissue.
The final study cohort included 41 patients with intracranial lymphoma. Stereotactic biopsies with assistance of 5-ALA were technically feasible in all cases. Strong fluorescence was found as maximum level in 30 patients (75%), vague fluorescence in 2 patients (4%), and no visible fluorescence in 9 patients (21%). In 28 cases, samples were obtained from at least 2 different tumor regions; homogenous intratumoral fluorescence was found in 16 of those cases (57%) and inhomogeneous intratumoral fluorescence in 12 (43%). According to histopathological analysis, all samples with strong or vague fluorescence contained diagnostic lymphoma tissue, resulting in a positive predictive value of 100%. Analysis showed no influence of preoperative corticosteroids or immunosuppression on fluorescence.
The data obtained in this study demonstrate the technical and clinical utility of 5-ALA–induced fluorescence in stereotactic biopsies of intracranial lymphomas. Thus, 5-ALA can serve as a useful tool to select patients not requiring intraoperative histopathology, and its application should markedly reduce operation time and related costs in the future.
Barbara Kiesel, Mario Mischkulnig, Adelheid Woehrer, Mauricio Martinez-Moreno, Matthias Millesi, Ammar Mallouhi, Thomas Czech, Matthias Preusser, Johannes A. Hainfellner, Stefan Wolfsberger, Engelbert Knosp and Georg Widhalm
Glioblastoma (GBM) is characterized by distinct intratumoral histopathological heterogeneity with regard to variable tumor morphology, cell proliferation, and microvascularity. Maximum resection of a GBM results in an improved prognosis and thus represents the aim of surgery in the majority of cases. Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is currently widely applied for improved intraoperative tumor visualization in patients with a GBM. Three intratumoral fluorescence levels (i.e., strong, vague, or no fluorescence) can usually be distinguished during surgery. So far, however, their exact histopathological correlates and their surgical relevance have not been clarified sufficiently. Thus, the aim of this study was to systematically analyze tissue samples from newly diagnosed GBMs with different fluorescence levels according to relevant histopathological parameters.
This prospective study recruited patients who underwent 5-ALA fluorescence-guided resection of a newly diagnosed radiologically suspected GBM. Each patient received 5-ALA approximately 3 hours before surgery, and a modified neurosurgical microscope was applied for intraoperative visualization of 5-ALA–induced fluorescence. During surgery, tissue samples with strong, vague, or no fluorescence were collected. For each sample, the presence of tumor tissue, quality of tissue (compact, infiltrative, or no tumor), histopathological criteria of malignancy (cell density, nuclear pleomorphism, mitotic activity, and presence of microvascular proliferation/necrosis), proliferation rate (MIB-1 labeling index [LI]), and microvessel density (using CD34 staining) were investigated.
Altogether, 77 patients with a newly diagnosed, histopathologically confirmed GBM were included, and 131 samples with strong fluorescence, 69 samples with vague fluorescence, and 67 samples with no fluorescence were collected. Tumor tissue was detected in all 131 (100%) of the samples with strong fluorescence and in 65 (94%) of the 69 samples with vague fluorescence. However, mostly infiltrative tumor tissue was still found in 33 (49%) of 67 samples despite their lack of fluorescence. Strong fluorescence corresponded to compact tumors in 109 (83%) of 131 samples, whereas vague fluorescence was consistent with infiltrative tumors in 44 (64%) of 69 samples. In terms of the histopathological criteria of malignancy, a significant positive correlation of all analyzed parameters comprising cell density, nuclear pleomorphism, mitotic activity, microvascular proliferation, and necrosis with the 3 fluorescence levels was observed (p < 0.001). Furthermore, the proliferation rate significantly and positively correlated with strong (MIB-1 LI 28.3%), vague (MIB-1 LI 16.7%), and no (MIB-1 LI 8.8%) fluorescence (p < 0.001). Last, a significantly higher microvessel density was detected in samples with strong fluorescence (CD34 125.5 vessels/0.25 mm2) than in those with vague (CD34 82.8 vessels/0.25 mm2) or no (CD34 68.6 vessels/0.25 mm2) fluorescence (p < 0.001).
Strong and vague 5-ALA–induced fluorescence enables visualization of intratumoral areas with specific histopathological features and thus supports neurosurgeons in improving the extent of resection in patients with a newly diagnosed GBM. Despite the lack of fluorescence, tumor tissue was still observed in approximately half of the cases. To overcome this current limitation, the promising approach of complementary spectroscopic measurement of fluorescence should be investigated further.


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The Legend of Dan
Paperback, 308 Pages
Price: $12.24
Prints in 3-5 business days
Tom, Two-Dan $mith (sic) thought his life couldn't get any worse, until a gorgeous alien turns up at his door, and drags him off on a quest to sort out the company responsible for all the troubles in the galaxy. But as is usual with Tom, what glitters is nothing more than polished coal. His guide has another agenda, using him as cannon-fodder. Taken in by her charms, he follows her directions, surviving by sheer luck and circumstance only, to the very end of Time itself, and discovers a confluence of unimaginable universes and an alien plot to take over the lot. If that wasn't bad enough, Tom has to challenge a super-intelligent being, created by a brewing accident and a lot of radiation... and our man's not even sober by now.
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Product Details
- 9780244777777
- Copyright
- Robert Wingfield (Standard Copyright License)
- Edition
- 8
- Publisher
- Robert Wingfield
- Published
- September 11, 2019
- Language
- English
- Pages
- 308
- Binding
- Perfect-bound Paperback
- Interior Ink
- Black & white
- Weight
- 1.15 lbs.
- Dimensions (inches)
- 5.83 wide x 8.26 tall
- Product ID
- 24242458
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What to Look at to Determine if you are Pregnant
We all know how we came into this planet. For nine months we were in our mothers' wombs. The gestation period is in itself a lengthy period of sacrifice. But through this, we found ourselves here. Have you ever then asked yourself how they came to know they were pregnant with you? Or maybe, are you asking yourself whether at the moment you are pregnant? Pregnancy can be such a tricky and anxious thing especially if it is your first time. One may not fully understand what is happening from start to finish. To help you get a foothold, we have prepared this article to enlighten you on how to know if you are pregnant.
We are going to go through some simple, common yet important signs you have heard or not. It is impossible to talk about pregnancy without talking about sex as the two are inseparable. The question of when you last engaged in intercourse becomes crucial. Did you use protection or are you on any form of contraception? These queries here basically lay the foundation for everything discussion that follows. Pregnancy sets in when the fertilized egg is implanted, which occurs within 6 to 10 days of unprotected sex. So first, find answers to these queries.
Missed periods is another sign you need to look out for. Missed periods are among the first signs of pregnancy though they may be deceiving. You cannot conclusively confirm pregnancy based on missed periods. The argument for this reasoning is that there exist many reasons as to why you may have missed your period. Sudden weight gain, some eating disorders, stress in plenty and regular contraceptive use may be reasons for having missed periods. The best thing to do here is consult a medical practitioner for better guidance.
Nausea and vomiting is another key sign. Nausea and vomiting set in about three weeks from conception making this sign more reliable. It is a sign that the level of hormones in the body is increasing in preparation for full-blown pregnancy. It is often referred to as 'morning sickness' but doesn't necessarily mean it will occur in the morning only. Common aromas of food, perfume or anything out there may make you feel nauseous.
The most reliable sign you can use to confirm pregnancy is the result form a pregnancy test. Taking a home pregnancy test could give you the answer you want clearly. It works best when one has already had their period. If you take it earlier than this, it may give a negative result even when you are pregnant. You can get the pregnancy test at drug stores or your local convenient grocery store. Clarification can be sought from a doctor on the result gotten.
How I Achieved Maximum Success with Reproduction


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Finance Minister Abul Maal Abdul Muhith on Monday hoped that the country's people will never make any mistake to select their leaders in the next parliamentary polls.
"I'm sure they would elect those who will devote themselves to people's welfare," he said.The finance minister said this while distributing tax cards, crests and certificates to 202 highest taxpayers at national and district level at the Tax Card Giving Ceremony-2018 held at a city hotel.
State Minister for Finance and Planning MA Mannan and President of Federation of Bangladesh Chambers of Commerce and Industry (FBCCI) M Shafiul Islam spoke on the occasion as the special guests. National Board of Revenue (NBR) Chairman M Mosharraf Hossain Bhuiyan chaired the event.
At the programme, the NBR chairman handed over a lifetime honour award to the finance minister for his contributions to the country's economy.
The finance minister said the government has been trying hard for the last couple of years to enhance the growth of annual national income by 2 percent from the present 1.7 percent.
Mentioning that the overall revenue collection has almost tripled over the last 10 years, Muhith hoped that Bangladesh would become a prosperous developed country by the year 2040.
Speaking on the occasion, State Minister MA Mannan said the government encourages the NBR to increase their association with the business community and the taxpayers to enhance realization of tax.


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World War II historians do not commonly discuss how the leaders of the two countries (NAZI Germany and Soviet Union) conceived of national policies that coverged on Eastern Europe in general and the Ukraine in particular. One historian has focused on this in the area he calls the Bloodlands, the region of Eastern Europe that runs from the Baltics, through Poland, Belarus, and south to the Ukraine and eastern Romania. [Snyder] World War II ws an industrial war, but in large measure the agrarin policies of the Soviet Union and NAZI Germany lay at its heart. Here the Ukraine was especially important to both Hitler and Stalin and both deciced to pursue agraian policies premised on genocide. Agricultural policies were central to the plans fornulated by both leaders. Stalin in his First 5 Year Plan launched the rapid industrialization of what was still a largely peasant country. His plan conceived of financing that industrialization by seizing the land of peasant farmers which would allow him to divert resources from the country side to the expanding industrial cities. The peasabts would thus be allowed to keep less of the crops they harvested. Stalin combined this basic policy in the Ukraine. He was concerned about the Soviet Union's ability to hold ont this vital region because of the Ukranian nationalism and resistance to Soviet rule. He thus went even further in the Ukraine, creating a horrible famine to undermine Ukranian nationalism and resistance to Soviet rule. Stalin never spelled out his intentions fully. Hitler was more frank in Mein Kampf where he enuncisted Germany's need for Lebensraum. And this was the goal of Operartion Barbarossa (June 1941). The NAZI killing plan was more clearly detauled in Generalplan Ost. Hitler's agraian policy was also central to the NAZI regime and it also focused on the Ukraine. Hitler concerived that the answer to Germany's dependence on foreign food imports was an agrain policy based on seizing the East, murdering large numbers of the Slavic population, and finally exporting German farmers to rule over the enslaved Slavs that had been allowed to live. The NAZI plan was so horrific that the Ukranians even after Stalin's represive policies and policies turned against the Germans. It is no accident that the great bulk of World War II combat took place in the Bloodlands, about 90 percent of combat. In large measure World War II was fought and decided in this area after the deaths of millions of civilians. A tragic accident of history is here that the Jewish population of Europe was concentrated. And it was here that the killing phase of the Holocaust began.
Snyder, Timothy. Bloodlands: Europe between Hitler and Stalin (Basic Books: New York, 2010), 524p.
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Copywriter, Marketing
Magic Leap, Inc., Plantation, FL
See jobs at Magic Leap, Inc.
Job Description
Magic Leap is seeking a Copywriter with a passion for language, strong conceptual thinking and integrated communications. This effective and creative copywriter will work across all mediums and platforms – social, web, video, print, etc. – in short and long formats to help interpret Magic Leap's voice by helping to own tone-of-voice.
- Interpreting the Magic Leap voice by helping to own tone-of-voice across multiple touch-points including, website landing pages, blog, email, direct mail, and social
- Ideating copy that connects our augmented reality offering to our customers in new and innovative ways
- Brainstorm, write, execute and iterate new concepts that continue to power our growth alongside our other creatives
- Perform as a key member of the marketing team to craft content that will propel consumer and enterprise adoption of new technologies
- Interpreting the Magic Leap voice by helping to own tone-of-voice across multiple touch-points including, website landing pages, blog, email, direct mail, and social
- Write original persuasive copy that engages, shifts behavior and drives action
- Develop a broad range of concepts and solutions that are compelling, unique and memorable
- Work across a wide variety of communication platforms – web, email, social content, print ads, video etc.
- Ability to understand and write effectively for a wide range of industries from healthcare, consumer products, telecommunications, sports, travel and entertainment
- Concept integrated ideas and bring them to life
- Translate creative ideas into compelling copy
- Proofreading and editing
- Strategically collaborate with art directors, social media teams, media other marketers
- Work with managers to fine tune message platforms that align strategy and brand guidelines
- Manage multiple projects simultaneously with attention to detail and deadlines
- 3+ years of copywriting experience at another fast-growing startup or ad agency
- Experience writing for a single brand across many different customer touchpoints
- Experience concepting new ad campaigns as part of a larger creative calendar
- Experience with A / B testing copy to drive better and better content
- Ability to foster strong working relationships with team members and partners
- Ability to work in a fast-paced environment, a self-starter
- Excellent written English skills
- Basic knowledge of SEO
- Good understanding of our products and brand
- Ability to work independently
- BA/BS Bachelor's Degree in Marketing/Communications or related field
Additional Information
- All your information will be kept confidential according to Equal Employment Opportunities guidelines.
About Magic Leap, Inc.
How It All Began October 5, 2017 Today, Magic Leap is a company made up of hundreds of artists, engineers, explorers, and dreamers from around the globe, all chasing their curiosity toward the same goal – bringing together the digital and real worlds to advance human potential. But it all began on a road trip to Austin when we asked the question – "what if computing could spill outside the computer?"


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Personal Banking
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For the quickest answer, search previously asked questions below. Chances are, others have asked a similar question and there's already an answer waiting for you. If you can't find a match, ask a new question and our team members will answer.
Allyson, New York
July 9, 2015 04:10:04 PM
Borrowing & Managing Your Credit
1 Response
In reply to Allyson, New York
Thanks for connecting with us here at TD Helps, Allyson. We are happy to help guide you in the right direction to inquire on the status of your Home Equity Loan.
There are a couple of options you have to obtain the status of you loan.
Your first option is to call us at 800-937-5020 to speak with one of our dedicated Financial Solutions Representatives, who are available 24/7. If you prefer, you could also visit your local TD Bank Store for help. For hours and locations near you, check out: http://bit.ly/TDStores.
You can also expect a letter in the mail with your loan decision within 10 business days after you've submitted your application.
Let us know if you have any other questions and have a wonderful afternoon!
Justin B, Mount Laurel
July 9, 2015 04:10:36 PM


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2006 RECREATION Feudal warlord arriving, dismounting, and talking to assembled peasants between 500 and 1000 / Europe - stock video
Your Easy-access (EZA) account allows those in your organization to download content for the following uses:
- Tests
- Samples
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It overrides the standard online composite license for still images and video on the Getty Images website. The EZA account is not a license. In order to finalize your project with the material you downloaded from your EZA account, you need to secure a license. Without a license, no further use can be made, such as:
- focus group presentations
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- any materials distributed outside your organization
- any materials distributed to the public (such as advertising, marketing)
Because collections are continually updated, Getty Images cannot guarantee that any particular item will be available until time of licensing. Please carefully review any restrictions accompanying the Licensed Material on the Getty Images website, and contact your Getty Images representative if you have a question about them. Your EZA account will remain in place for a year. Your Getty Images representative will discuss a renewal with you.
By clicking the Download button, you accept the responsibility for using unreleased content (including obtaining any clearances required for your use) and agree to abide by any restrictions.
- 1 Minute or Greater
- 2000s Style
- 2006
- Adult
- Adults Only
- Archival
- Arrival
- Blurred Motion
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- Caucasian Ethnicity
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- Day
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- Documentary Footage
- Dolly Shot
- Europe
- Farm Worker
- Film
- Front View
- HD Format
- Harvesting
- Horizontal
- Horse
- Horseback Riding
- Leaving
- Lifestyles
- Low Angle View
- Medieval
- Medium Group Of People
- Medium Shot
- Men
- Non US Location
- One Animal
- One Person
- Only Men
- Outdoors
- Panning
- People
- Real Time
- Rear View
- Reenactment
- Riding
- Side View
- Talking
- Tilt Down
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- Tracking Shot
- Wide Shot


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2016-17 MVP Russell Westbrook is one of the most entertaining and energetic players in the NBA, perhaps in the entire history of the league, and because of his style of play, many fans around the world have fallen in love with the Oklahoma City leader.
Despite his low-efficiency when shooting the ball, and his high rate of turnovers, Westbrook is still one of the most popular players in the NBA, based almost entirely on his dedication to the game. So why is it that Westbrook — one of the faces of the league right now — can't move merchandise on par with big names such as LeBron James and Steph Curry?
Surprisingly, in his MVP year last season, Westbrook only ranked fourth in total jersey sales across the season, beaten out by the likes of James, Durant and Curry. For a man who averaged a triple-double and was the league MVP, only coming fourth in jersey sales is head-scratching to say the least.
To add to this, Westbrook's Jordan Brand sneakers haven't been flying off the shelves either according to sale numbers.
To compare, during Derrick Rose's MVP season back in 2011 — an easy comparison to make as both are MVP's, and both are athletic point guards — the Chicago Bull was the top jersey seller for that season, as well as selling double the amount of shoes as Westbrook did in his MVP campaign.
Top jersey sales on https://t.co/Ie3TSh2Vcw for 2016-17 season. Russell Westbrook No. 4 pic.twitter.com/qxwnmstz4D
— Erik Horne (@ErikHorneOK) April 11, 2017
For a player as popular as Russell Westbrook, these statistics are extremely worrying for his personal brand.
If Russ wants to have a profitable career after basketball, these sale issues should be ironed out as soon as possible before it starts costing him thousands, if not millions in lost revenue.


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Posted on December 21, 2018
All positions in the Armed Forces have opened to women to apply, but not everyone agrees on what this will mean for the future of the military.
Major Judith Webb, the first woman to command an all-male Army Squadron, thinks that 'differences need to be acknowledged' between men and women.
Sophie Faldo, former Army Officer and winner of the 2017 Great British Bake Off, says that 'physical standards are there for a reason'.


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- Product Description
Union Jack British Metal Dog Tags
Long live the Queen! These unique Union Jack British Metal Dog Tags are fit for the Queen's corgis or your favorite four-legged friend!
The Union Jack tags are sterling silver-plated and sealed with epoxy to protect the design from dirt, water, and scratching. All of your personalization is printed onto the design you select and laid in the round or square metal tag.
This process creates a jewelry-like tag that keeps your pup's very own Union Jack as regal as the day they got it.
Product Highlights:
- United Kingdom Flag in Vibrant Colors
- Easy to Read Pet's Name
- Alloy Base with Sterling Silver Plating
- Seal Protects from Wear & Tear
- Circle and Square Options
- Matching Hardware Included
Shape & Size:
- 1" Diameter Circle
- 1 1/8" Diameter Square
Est. Production Time: 4-6 business days.
- Vibrant British Flag Design
- Crafted by Our Artisan Partner
- Large & Easy to Read Dog's Name
- Epoxy Sealed to Stay Looking New
- Attachment Hardware Included
Woof! Looks like you forgot to personalilze this product. Did you want this item left blank?


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Black and White Damask Scalloped Favor Box$1.10
Product Features
- Vintage-looking elegant black and white damask scalloped favor boxes
- Unique shape with a beautiful scalloped edge and intricate black and white damask print
- Box has 4 holes at top center for threading and tying ribbon
- Inside of box is white
- Made from heavy cardstock to ensure stability
- 12"L x 3/8"W pieces of ribbon included
- Choose from 6 different colors of ribbon
- Assembly required
- Size: 1-5/8"W x 2-3/4"L x 3-3/8"H
- Quantity discounts available
Vintage elegance is the name of the game with these black and white damask scalloped favor boxes. With their antique damask print, these boxes would be perfect for a black-and-white or Victorian & Vintage Wedding Theme or bridal shower. Fill these sweet boxes with any favors of your choice, from candies to candles and more! The boxes are made from heavy cardstock, so they will retain their shape and provide a sturdy container for any favors you choose to fill them with. Each box has 4 small holes at the top center to make it easy to thread and tie a ribbon. Precut 12"L x 3/8"W pieces of ribbon in your choice of 6 colors are included to jazz up these adorable favor boxes. Some assembly is required. Each box measures 1-5/8"W x 2-3/4"L x 3-3/8"H.
- From Favors by Serendipity
- Free Shipping over $139 (Coupon Code: FREESHIP)


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Treasuries were gained and work from home making bows brokers had increased overnight, with the launch year rate therefore more than 8 news points, as encouraging infinite data out of the United States and Market Wicks Numerous international forex markets have in the forex market, and it is a different reason for the regulatory liquidity of the quote. TransferWise, one of London's best-funded central technology firms, is Planning travelling services of avid currencies date back to Unique Data entry jobs from home newfoundland and have learned in such scenarios since then.
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The Watch Club is devoted to ensuring that purchasing a quality piece is a truly effortless and satisfying experience.
With the purchase of every timepiece The Watch Club offers free bracelet fitting.
A simple method to size your wrist is to, take a measuring tape, wrap it around your wrist and make a note of the number at which the tape meets zero. If a tailors measure is not available you can simply use a strip of paper or length of string and mimmic the same process. Once the length is marked proceed to measure with a straight rule.
To ensure a comfortable fit add 1.00cm to the length measured.
Please send through your measurements and purchase number to


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I miss my coffee! I am drinking tons of water though, which I don't mind as I always drank alot of water. Coffee is a big trigger for me, but as you see in the graphic, I'm not all to awake without it!
Another day smoke free,and I seem to be trembling alot. Anyone else have that problem? I planned to use the patch and keep forgetting to put one on. Maybe I should get to that.
I was thinking and wondering how many times did you slip before you got your forever quit? I had I think 4 slips before I got as serious as I am now.
Well I'm just rambling so I'm going to finish off by wishing you all a happy smoke free day!


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Join us this summer for a fun swim!
Swim Lessons
Six – 30 min lessons
$250 per swimmer
Hello! My name is Sophie Smith and I am currently a student at DePaul University. I have been a swim coach for four years at Orinda Park Pool and I am very excited to teach lessons at Oak Springs this summer!
To enroll in our swim classes please complete the following form. After submitting the form you will be directed to a payment page where you can use a credit card or PayPal to pay for the lessons.
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Hey guys! It's been a while since I've done a Planner Previews post. But it's the new year and I am trying to get back on track with keeping up here on the blog! So, tomorrow (January 4), I'll be releasing a handful of new items in the shop! Here you can get a sneak peek of what they are! Let's get right to it, shall we?
The first big thing is our release of B6 monthly kits!! I finally figured out a way to make a kit that should ultimately work in any insert from any shop. That was the only reason I hadn't made them before now! Here's how January's looks in my B6…
I honestly couldn't be more excited about this! 🙂
Next up is everyone's favorite…. Wacky Holidays! February's are ready!
Then we've got a few new foil options! Books for all those who love to read and small months script! I've got a larger months script in the shop already which is perfect for most planners, however is way too big for TNs. These are sized with the TN in mind since they are only a half inch tall.
I am having some technical difficulties with a few other things I'd like to release. But I'll keep working on them and try to get them done. And who knows how much more I can get finished before tomorrow! Stay tuned to our social media for when releases go up tomorrow!
And in case you need a reminder….


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Name: My sword bible for nokia
File size: 538mb
Language: English
Rating: 1/10
Download MySword Bible for Nokia 3, version: for your Android 3, file size: MB, was updated /15/09 Requirements: android Ice Cream. MySword Bible - With MySword, you can study the Bible without banner ads, compare different translations, look up Strong's Hebrew and Greek Lexicon, read . Software for Java phones - posted in MySword: I'm not sure where this should be posted. I was wondering if there is any good bible software.
Download the latest MySword software - a free Bible study tool for Android device , Bible study has never been this easy. Swahili Union Version (SUV) - Hundreds of versions in + different languages - the Bible that goes with you anywhere. Download now or read online. App description: On more than million devices around the world, people are reading, listening to, watching, and sharing the Bible using the rated Bible.
7 Comments Posted in Bibles, e-Sword, Go Bible/Java, mySword, PocketSword, theWord Tagged android, catholic bibles, e-sword, go bible, gobible, java, nokia . The Bikol Popular Version (BPV), commonly known as the Marahay Na Bareta Biblia, is a Bikolano translation of the Christian Bible and was. This basic installation includes the King James Bible and the King James with Strong's numbers study Bible, the Strong's Lexicon, Smith's Bible dictionary.


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Progressive lenses that provide sharp vision and smooth transitions at any distance.
Get the latest news and information on eye health, the optical industry and our commitment to improving lives by improving sight. Because we know so much of life is worth seeing, we want to help people see and live life through the best lens.
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Mar 17, 2019
Opening Up to God's Leading
Part 2 in our Get Focused Series. We are up to the letter "O" this morning looking at what it means to be open to God's leading. Pastor Bill lays out a theology of guidance from Proverbs 3:5-6 and then historically looks at how God leads His people.
- Mar 17, 2019Opening Up to God's LeadingMar 17, 2019Opening Up to God's LeadingPart 2 in our Get Focused Series. We are up to the letter "O" this morning looking at what it means to be open to God's leading. Pastor Bill lays out a theology of guidance from Proverbs 3:5-6 and then historically looks at how God leads His people.
- Mar 10, 2019Finding time to be with God (Psalm 63)Mar 10, 2019Finding time to be with God (Psalm 63)The first message in a six part series on our 2019 theme: Get Focus. The first letter of "FOCUS" stands for finding time with God and Pastor Bill this mornings challenges us that if we to find focus in the ordinary that we need to find time to be with God. Using Psalm 63 we unpack very practical ways for us to find time to be with God and to make that time matter.
- Dec 20, 2018Power of LoveDec 20, 2018Power of LoveThe last in our Advent series that is examining how God's love demonstrated through Christ's ministry on earth impacts and effects our love for others. This week we look at the power of Christ's love to change everything and how our love for others can change feelings and situations.
- Dec 16, 2018The Peace of LoveDec 16, 2018The Peace of LoveAdvent Week 3 - the Peace of LoveIn this week's Advent message we discover that when you practice biblical love you will experience peace. Once again we see how Jesus demonstrates this principle. Christ's love for us brought us peace with God. Jesus bore our sins and covered them with His blood. We are called to let our love of others cover a multitude of sins bringing peace to one another.
- Dec 9, 2018The Perspective of LoveDec 9, 2018The Perspective of LoveAdvent Week 2 - The Perspective of Love (you can start at about 6:00 after the group game and a video)What is the focus of your love? We learn this week that the focus of Jesus' love was all for our sake. What He did, He did for us. From that lesson we learn that love is not self-seeking but seeks the welfare and blessing of others.
- Mar 4, 2018I believe in the Forgiveness of SinMar 4, 2018I believe in the Forgiveness of SinIn this article of the Apostles' Creed we summarize the entirety of the Christian walk. This is the phrase that Martin Luther called the most important of the Creed. Rediscover the power of the gospel at its very foundation in this message on the forgiveness of sin.
- Feb 18, 2018I believe in the ChurchFeb 18, 2018I believe in the ChurchThis is perhaps the most controversial of the phrases from the Apostles' Creed--at least for Protestants. What do we mean by affirming the catholic Church? Discover the how powerful the doctrine is to our walk with Christ.
- Feb 11, 2018I Believe in the Holy SpiritFeb 11, 2018I Believe in the Holy SpiritIn this segment of our study on the Apostles' Creed we examine the work of the Holy Spirit and why it matters that we have a defined and biblical theology of the Holy Spirit. This is a studio recording because the live recording had a sound problem.
- Jan 28, 2018I believe in Jesus part 2Jan 28, 2018I believe in Jesus part 2This is the second of two sermons on the Apostles' Creed teaching on Jesus. In this message we explore the work of Jesus and what He accomplished in the life of the believer.Key Text: Colossians 1:15-23
- Jan 21, 2018I believe in Jesus part 1Jan 21, 2018I believe in Jesus part 1We move into the second section of the Apostles' Creed this morning as we examine our belief in Jesus Christ God's Only Son our Lord. In the first of two messages we look at the nature of Christ--who is He.Key text: Colossians 1:15-20
- Jan 7, 2018Apostles' Creed — I believeJan 7, 2018Apostles' Creed — I believeWe kick off our 2018 theme at the beginning of the year: Why it Matters. Using the Apostles' Creed as our guide we will examine why it matters why you believe. When many today don't fully understand the difference their faith makes we will dig deep into God's truth to reveal that every part of our faith has the potential change every aspect of our lives.
- Jan 29, 2017The Warnings of Worship part 2Jan 29, 2017The Warnings of Worship part 2In this final message in CAC's January series on worship we finish examining the various warnings to each of the worship instincts we identified previously. Using various accounts from the Old and New Testament we learn that if we are not careful worship can become a dangerous service to the Lord.


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Episode 84: It Fell Into To Me Into Head!
Part 1 of a 2-part series!!
Wpadło mi do głowy!
English Phonemes: "FPAH-dwoh mee doh GWOH-vih"
Literal Translation: It fell into to me into head!
Elegant Translation: It fell into my head!
English Equivalents: This sprang to mind. It popped into my head.
This phrase can be used when you have a sudden idea or spark of inspiration. You can easily use this phrase, or the Extra Credit version if you're feeling even more adventurous, and want to emphasize with oomph just how random your sudden idea is.
Wpadło = he/she/it fell/dropped into [3rd per. s. past tense]
Mi = to me [obj. form]
Do = to, into [preposition]
Głowy = head [s. obj. form]
Ależ mi to wpadło do głowy!
Literally, "Oh how to me this fell into head!"
In other words, "What a thing to pop into my head!" or "Wow did this fall into my head!"
Ależ = slang of ale = interjection word which in this context means "oh" or "oh how"
To = this
Next week we'll cover a related phrase where the idea that grabs you doesn't want to let go!
Email us! email@example.com
Visit the website! www.howyousay.fm
Tweet us! @HowYouSayFM
Subscribe to our YouTube Channel!
Rate the show!


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From the case: Uterine tube
From the case: Uterine tube
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contributed by Dr Abdulmajid Bawazeer on August 14, 2019
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There is also an observation regarding these games and their players where children who are naturally aggressive prefer playing this type of games to others.
This observation waters down the chances of violent games leading to violent behaviour in children. When interviewed, some kids who play this type of games say that they are not negatively affected by the games. This is definitely backed up by their non violent behaviour. It has also been observed that violence displayed on television such as in action movies or news has more chances of leading to violence in children that the violent games.
However, it is important to note that when a child plays a violent game he is likely to experience some physiological effects. These effects include an increase of both heart rate and brain activity. In conclusion, it is safe to say that violent games barely lead to violent behaviour in children.
Each of essay sections should be well defined and written clearly. This means you should know what details to include while minimizing the amount needed. You may need to rewrite each section more than once before settling on your final copy.
You should also remember to proofread, edit, and revise as these elements help make your structure more solid. Think about your details in how you want readers to view examples of persuasive essay from your perspective. Expository essay Stages of writing Study help Buying a plagiarism free sample Topics for an argumentative paper Persuasive essay topics on politics Good compare and contrast essay topics Creating a winning essay topic Writing a strong essay Great high school essay topics English essay example: Violent Video Games Video games always provide a great pass time activity for children.
Struggling with your essay on video game violence? Essay Tutorials Gun violence: On the other hand, some people, although they already know some of the positive aspects of video games, still believe that the negative will overcome the positive ones. In playing the games, kids are likely to become desensitized to gory images, which could make them less disturbing and perhaps easier to deal with in real life.
For patients suffering from arachnophobia, fear of flying, or post-traumatic stress disorder, therapists are beginning to use virtual realities as a desensitization tool. Additionallyal though violent video games might expose children to violent behavior, the amount of violence are not as great as the ones in movies and television.
The news is filled with stories of war and murder, and nearly every movie contains some form s of violence. Plus, these two media are different from games in a very important way because they involve real people, not computer-generated characters.
As mentioned by Dr. Kipling D. Williams Ph. Williams also pointed out that, besides playing violent games, genetics and environmental aspects and self-control must be considered as some of the factors that contribute to the increase in aggressiveness. Genetics tend to play a huge role in personality of a jobs cover letter. Some person might have a tendency to be more rebellious and aggressive.
Moreover, easier access to firearms in several countries can lead to violent thoughts and behaviors. If the person does not have a solid self-control, it can lead him to a violent behavior.
Williams strongly believes that there is no single cause that can lead to an increase in aggressive behavior in children, consistent with Dr. Craig A.
Anderson, Ph. D statement during an interview with MSNBC, "Video game violence is only one risk factor for aggressive behavior in the real world.
There are also dozen or so known risk factors. It is not the smallest risk factor, but it is an important one. Finally, I believe that regulations will not prevent children from playing the games they want to. They will still get their hands on those games, w hether from a parent, sibling, or older friend. I think that the responsibility lies within the parent, not the government.
Schaffer, Amanda. I will of course mention you and your references. Yes, this is for a school project. Thank you for your comment! I really appreciate it! Hey man, since its for school and english is not your native lanuage, I decided to help proof read your paper for you. I would still have a teacher look over it with you to help clean it up a little. I liked it and its a decent paper. Good luck. The video game phenomenon is somewhat new in this modern society.
Although they often are entertaining, the contents have become more violent and disturbing as computing technology has advanced. These days the popularity of violent video games have caused major controversy.
Parents and experts feel that some games are just too violent. They have begun to demand that the government regulate the sale of these games to protect childern. However I strongly believe that violent video games do not cause an increase in aggression in adolescents.
Furthermore, the forceful plan by the government is a reaction to an exaggeration of the effects of violent video games and these worries are unfounded. Looking past the violent contents, video games have several positive aspects.
The player acts as the leader of an elite anti-terrorist squad consisting of members. At the beginning of the game players can choose how to infiltrate the terrorist compound. They can plant an explosive on the door, use a fast rope from the rooftop or simply breach into several doors to create a surprise assault. These options will ignite the sense of logical thinking and strategy formations in ways which formal education does not.
Aside from the cognitive aspects, video games are also a tool for social interaction. Friendships can be developed through playing video games and ultimately keep friendships away from drug use and violent activities.
Many of the most popular video games today have either a multiplayer or online mode. Glasgow university essay checking service game focuses on eliminating the other team so teamwork has a major role in succeeding in the game. With a headset a combination of a headphone and a microphonemy team members and I discuss and plan strategies effectively.
We also talk about our backgrounds as well, getting to know each other while playing. Personally meeting lots of people online has helped to develop my English abilities since English is not my first language and social skills. For some people, starting a conversation with a stranger can be really tough and video games have helped me learn how to. On the other hand some people, although they already know some of the positive aspects of video games, still believe that the negative aspects will overcome the positive aspects.
Additionally, although violent video games might expose children to violent behavior, the amount of violence is often not as great as seen in popular movies and television. The news is filled with stories of war and murder, and nearly every movie contains some form of violence. Williams also pointed out that, besides playing violent games, genetics and environmental aspects along with self-control must be considered as some of the factors that contribute to an increase in aggressiveness.
Some people have a tendency to be more rebellious and aggressive. More importantly, easier access to firearms in several countries can lead to violent thoughts and behaviors. D who made this statement during an interview with MSNBC, "Video game violence is only one risk factor for aggressive behavior in the real world. They will still get their hands on those games that they desire, whether from a parent, sibling, or older friend. I think that the responsibility lies within the parent and not the government.
Thing that struck me the most:
Please join StudyMode to read the full document.
There is much hype surrounding the launch of every new game system including Game Cube, XBox, Playstation 3 and all of their handheld portable equivalents. Affecting all sorts of people from children as young as age 4 all the way to 45 year-old adults, these video games have called for concern in our society regarding issues such as addiction, depression, and even aggression related to the playing of video games.
What is more, some of these games being played like Mortal Combat, Marvel Do video games promote violence essay.
Capcom, and Doom are very interactive in the violence of slaughtering the opponent.


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To Whom so ever it may concern,
Greetings from Materials Science & Engineering Conference 2019!!
The purpose of this letter is to solicit your gracious presence as a Speaker at the upcoming "4th International Conference on Materials Science & Engineering" that will be held during March 18-19, 2019 Amsterdam, Netherlands.
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Angela Smith's Information
- Location: , GA 30038
- Title:
- Experience: Twelve+ Years
- Willing to Relocate: Yes
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- Work Status: U.S. Citizen
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- Angela's LinkedIn
- Full Time
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Work Types:
To contribute exceptional sales ability, account management, and communications skills to a challenging Sales Management position.
· Trained in sales, product knowledge, and marketing skills.
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Sales / Marketing
< Design and implement successful programs to ensure that customers received exceptional service. Negotiate settlement of disputes between company, members and builders. Trained new employees; coordinated workshops and seminars. Dealt with lenders, builders and attorneys. Established a large personal customer base. Maintained a preferred customer list.
< Utilized effectively management skills including planning, organizing, directing and controlling the activities of the properties or departments to ensure smooth work flow and continued company profitability. Demonstrated knowledge and understanding of company ' s quality standards and ability to handle personnel, and pressure situations. Negotiate contracts; set forecasts; motivate staff and critique their abilities. Maintained inventory/quality control, merchandising, shipping/receiving, accounts payable and receivable, banking and cash management.
Morris and Raper Realtors, Inc., Atlanta, GA 8/07 – Present
New Homes Sales Specialist/Realtor
· Currently responsible for management and selling a total of $5,000,000 of inventory in a townhome condominium community. Provide professional and financial assistance to clients in search of residential, commercial and investment property. Market and advertise homes for sale averaging 2 sales per month in a challenging real estate market and economy. Schedule, organize, and give visual displays and presentations while hosting events to provide information on buying and incentive opportunities to real estate agents, home owner association and neighboring communities. Specialize in first-time home buyers, while educating clients of the advantages of becoming a homeowner.
Crown Realty Professionals, Inc., Conyers, GA 10/04 – 7/07
New Homes Sales Specialist/Realtor
· Onsite sales agent responsible for selling starter homes priced in the $140's. Maintained sales quota of 8 per month, while assuring builder 100% of total sales price with builder's preferred lender. Required to select floor plan and style of home for each homesite in community as well as exterior and interior colors for all inventory homes. Scheduled all builder/buyer meetings and closings with closing attorneys.
MDC Homes, Alpharetta, GA 11/02 – 10/04
New Homes Specialist
Business Account Executive (11/00 – 7/02)
Retail Sales Representative (2/00 – 11/00)
Georgia MLS Training Institute Real Estate License Tucker, GA
Owens Technical College Business Management Toledo, OH
Available Upon Request.
· Provided customer service and sales assistance to customers, averaging 40-45 new activations and $2,000 in accessory sales per month, exceeding management set quotas. Assisted with cash management procedure as well as opening and closing of store on daily basis. Recognized as the top sales rep for 4 months consecutively within my store location and one of the top ten within all Metro Atlanta retail stores for the months of June and August.
Customer Service Representative (7/95 – 6/97)
· Received 20 to25 incoming calls on a daily basis providing customer service and technical assistance to customer in a call center environment. Recognized for excellent management of time and being able to provide resolution while assisting customers. Handled escalated and irate customer calls. Maintained 95% to 100% scores for quality assurance measures on a consistent basis.
· Developed professional business relations with companies of all sizes. Provided technical consultations and solutions for wireless service related needs. Marketed wireless communication solutions to high-level executives. Recognized as top sales rep of the month for July 2001. Maintained an increase in sales and customer service satisfaction by 40% to 50%.
· Real Estate sales agent responsible for selling new homes in several different communities priced from the $140's to $400's. Provided management with all necessary paperwork and reports by their required timeline. Assist with sales and marketing strategies to produce additional traffic to neighborhoods, scheduled broker breakfasts and luncheons to present an opportunity to co-op agents as well as find prime locations for permanent directional signs. Recognized numerous times with certificate of excellence awards for internal and external customer satisfaction.
Verizon Wireless, Atlanta, GA 7/95 – 7/02


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I prefer to code on:
- Windows
- MacOS
0 voters
Feel free to share with us why you prefer one or the other in the comments.
@Bobino shared his own preference in the post "Why Mac?"
I prefer to code on:
0 voters
Feel free to share with us why you prefer one or the other in the comments.
@Bobino shared his own preference in the post "Why Mac?"
mac. Plugins for development are better (mbs). WebViewer can be debugged. Mac also is easier to use with other development (web, php, js etc).
I use windows for testing and making minor ui fixes for client apps if they use windows. My windows laptop also is always ready to be a temporary work computer if something happens to my mbp.
unfortunately, it is not just a question of what I do prefer - it is a question of what OS the customers are running…
For 'industrial' use cases, it is windows
Worst of all: The more filemaker refuses to run on macOS older than the latest 2 version, the more customers need to check for a plan B - means windows
Windows, mainly due to the continuity over the years and not being constantly forced to upgrade to match Apple's annual updates, lack of backward compatibility and lack of support for anything over 3-years.
FileMaker solutions are usually critical to running a business/organisation. Dull, boring and 'it just works' is usually what business owners require, avoiding budget spend on changes forced upon them. Hence - Windows! (from someone who still uses a Mac and has done so since 1985).
Yes… forgot to mention that in our company, we all have Mac's (Windows on virtual machines) - but on customer sites, we are on windows
Here we each choose what to use, mostly MacBooks or Surface Pros (have been tempted, but a new MacBook Air has now tempered that).
Virtually all development on Windows streamed over the Internet using RemoteApp servers, so can use Linux, ChromeBooks, Android or whatever if we really wanted to. Occasionally some local development and occasionally for a Mac client.
The customer with whom I am currently working on a FM project evolved from a Win-only office to a mixed Mac-Win landscape. People can have the machine they are comfortable with. This looks like a reasonable approach in office work.
macOS for me
MBS makes me stay with macOS in FileMaker, experience is far more productive, although many of my customers work on Windows and a Windows environment is always available
Willkommen hier im Forum (-:
Must admit there are pros and cons to both platforms, but very grateful we have the choice to use either.
Prefer the Mac's drop down menus, searching for layouts and scripts in FileMaker, but it drives me nuts in the script debugger when pressing F6 quickly to step through, whereas Windows doesn't seem to put any limitations on the speed of this.
Now we have SDI in the Windows version, it is much easier to write for both platforms.
One more plug for the poor relation here (remember being the poor relation all the time through the 1990s trying to convince companies from ditching the 'soon to go bust' Apple Macs for the all conquering Windows, but with the likes of the PowerBook 180 and 5300, almost couldn't blame them LOL!).
Back on track, the restriction of 12 indents on the Mac within the calculation engine can create havoc with the display of some calculations. This is particularly relevant now using a combination of Let() and While(). This was improved in the Mac version from a lower number to the 12 some versions back, but as a 'serial indenter', Windows seemingly unlimited number wins for me.
One I didn't realise until recently, that the script debugger and data viewer can be selected from the menu while actively using a card window on the Mac, whereas Windows has to have at least the script debugger running before the card is opened. One up for the Mac.
The function editor would benefit from a refresh, even on Mac
Ah, however I've just discovered that using Microsoft Desktop for Mac (beta in our case) and FileMaker via RemoteApp, if we have 2 windows open, then it is possible to select the second window as part of RDP, have full access to all menus, including the Tools menu, so open script debugger, swap back to the window containing the card window and start debugging.
Something you can't do on a standard Windows install. Plus one for streaming!
I must admit, I'm not a fan of the Fields/Groups and Inspector lists tagged to either side. The redraws and windows size changes are horrible on both Mac and Windows.
Same here. I prefer almost everything on the Mac, except for how slow it is to step through script execution in the Script Debugger. I also use Microsoft Remote Desktop to connect to a Windows session on a terminal server to debug a script. That has the added benefit of making it easier to fix bugs, as well, on my local Mac.
I also have a lot of custom-built utilities that process clipboard XML in various ways to dramatically improve development time, mostly built using AppleScript. That, combined with Keyboard Maestro, helps me avoid a lot of repetitive tasks.
While the Windows coding experience has gotten much better the Mac is really superior in many ways the most significant is the third party tools that only work on Mac (MBS mac os only features are huge), and noun project to name the most significant in my opinion. If FM had a better suite of support tools built in the gap may closer further but I would never use a Windows computer as my work computer only for FM programming so even if they were identical in every way in that regard I would still be on a Mac.


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