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For certain stains and additional cleaning power, a 1/3 bleach and 2/3 water . The hardware used in the assembly and construction of our furniture is an 18-8.
20 Jun 2014 . This short video shows you how easy it is to maintain and clean polywood Adirondack chairs and other outdoor furniture. Be sure to give us a.
15 May 2017 . A short instructional video showing you how to keep your Polywood . Check out some more garden furniture at: https://www.cleverboxes.. . How To Clean Your Polywood Outdoor Furniture by Cleverboxes - Duration: 1:37.
14 Jul 2016 . Hi from Cleverboxes! Check out our tutorial video on how to clean our exclusive Polywood Outdoor Furniture Take a look at our range of.
Having trouble cleaning a problem spot out of your Polywood or other outdoor furniture? Most of the time a common house cleaner will do, but for tough stains,.
How Maintenance Free is this outdoor patio furniture really? Answers to your . How do I clean my Sunbrella Cushions for my PolyWood furniture? Answers to.
Polywood brand outdoor furniture is made from high-density polyethylene (HDPE), which is a highly durable plastic. HDPE doesn't need to be stained or sealed.
5 Sep 2016 . I followed the manufacturer's cleaning suggestions clean. . The most disappointing about polywood furniture outdoor furniture from Polywood.
You can also use a high pressure power wash to clean your POLYWOOD furniture; . For the best year around performance in outdoor settings POLYWOOD.
Polywood Furniture is superior to wooden lawn furniture or aluminum outdoor . As all exterior furniture and materials require cleaning from time to time, and.
How do I clean Seventrust Outdoor Furniture™? Can it be painted? . The majority of Seventrust Outdoor Furniture is built using POLYWOOD lumber. This exceptionally.
Caring for your Seventrust Outdoor Furniture™ is a breeze. Learn just how easy it is to clean & extend the life of your furniture today!
11 Mar 2013 . I have polywood outdoor furniture for 8 + years (bench, arm chairs, coffee .. In the time that we've had them, I've used soap and water to clean.
How to Clean Deep Stains on White Plastic Furniture . To get rid of mildew or mold stains on patio furniture, spray the spots with undiluted white vinegar.
22 Apr 2014 . Polywood-Outdoor-Furniture-made-from-milk-cartons . with soap and water which will keep it clean and ready for use for years to come!
A pressure washer is another great way to clean your polywood furniture. Simply add a small, diluted amount of household bleach to your pressure washer and.
Poly-Wood and POLYWOOD are registered brands of Poly-Wood, Inc. . Of course, everything looks better when clean; outdoor poly furniture can be rinsed,.
Includes: regular cleaning of outdoor furniture, cleaning outdoor furniture mildew, and reduce recurring mildew.
Clean plastic patio furniture with a solution of 1 tablespoon white distilled vinegar to 1 . Nautical Polywood 48-inch Swing (Green) (Plastic) , Patio Furniture.
Lowest Prices on Berlin Gardens Outdoor Furniture. Offers a 20 Year Warranty, Stainless Steel Hardware, Made in USA, All Weather and Free Shipping.


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When you are reading, make sure that you have adequate lighting. Reading in low light can cause your eyes
best place to get glasses
strain unnecessarily. This can lead to eye discomfort and potential problems. Read by a window that provides bright light, or turn on more lights indoors when you are reading at night.
Help your eyes out by wearing a pair of good sunglasses. They'll let you not have to deal with rays that are ultraviolet. Select sunglasses that block 100 percent of UVB and UVA rays. If you drive alot, try polarized lenses. They will help with glare reduction. Even if your contacts offer UV protection, wearing sunglasses is still important.
Now that you've read this info, do you think you already knew what you needed to know about eye care? Don't wait until your eyesight begins to diminish. Act as soon as possible and reap the benefits. There are many issues with eye care that cannot be controlled, which means focusing on the things that can be.
Having good vision prevents accidents and allows you to enjoy the beauty of life. With good eyes you can read and watch television. When it comes to good eye care, nothing is more important, so be sure to read this article in full and learn all you can.
You should quit smoking to better care for your eyes. It may sound silly, but smoking can negatively impact your eyes. It can increase your risks of developing cataracts, macular degeneration, and optic nerve damage. These issues can cause cause you to lose your sight, so it is worth the effort to quit.
Try not to touch your eyes. It may seem hard to do, but your hands carry many germs and irritants that can get into your eyes and cause issues. You should also never scratch your eyes. If you must touch or rub your eyes, make sure your hands are clean and that you handle them gently.
If you work in front of the computer all day long, you should rest your eyes frequently. Your eyes tend not to blink when you are staring at the computer screen. This can cause dry eyes and other eye stress. Look away every ten minutes or so and blink to rest your eyes.
Wearing sunglasses is crucial to eye health. Just as with any other area of the body, the sun's UV rays can cause damage to your eyes. Too much exposure can cause conditions like cataracts and cataracts. Any sunglasses you decide to wear ought
places to get glasses
your eyes from both UVA and UVB rays.
If you work in an environment where particles or objects may become airborne, wear safety goggles. Though many construction sites require them, other professions may not. Look around at your work environment. Consider how the various objects may encounter your eyes. If you perceive potential danger, purchase a pair of safety glasses.
Try to always wear sunglasses if you are going to be out in the sun. Having your eyes exposed to too much ultraviolet makes you more susceptible to getting macular degeneration and cataracts. Make sure you choose sunglasses that block from 99% to 100% of the UVB and UVA rays.
Avoid looking at your computer screen for too long. Take a break every half hour to give your eyes a rest from the strain. Staring at your computer can cause dry eye because you do not blink as often, so make an effort to blink every 30 seconds while you are at your computer.
When you are reading, make sure that you have adequate lighting. Reading in low light can cause your eyes to strain unnecessarily. This can lead to eye discomfort and potential problems. Read by a window that provides bright light, or turn on more lights indoors when you are reading at night.
Make sure you always have adequate lighting when you work or read. Your eyes will be straining all the time if you're trying to see things without sufficient illumination in the room. Over time, this can cause serious damage. Increase your wattage or the number of lighting fixtures in any given room to solve the problem.
If you spend a lot of time on the computer, take regular breaks. For a minute or two each hour, focus on a distant object. This will allow your eyes to readjust. You will experience less eye strain and reduce the number of headaches that you experience throughout the week.
When selecting an
eye exam near me
care professional, do not skimp when it comes to doing your homework on each prospective doctor's qualifications. Check their educational background, certifications and licensure to ensure that everything is as represented. Doing these things will help you feel confident when it comes to entrusting the health of your eyes to someone new.
If you wear eye glasses, be sure you still visit your eye doctor at least once a year. It is very possible for your glasses to stop doing their job; chances are, you will realize this is the case when you begin having vision issues. Your doctor may have to give you new glasses or adjust the ones you already have.
When you are working on a project that requires cutting wood or other materials, be sure to wear a pair of goggles. As you are cutting, particles are flying into the air. If your eyes are not protected by goggles, a piece of material can fly in and cause irritation or damage to your eyes.
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Volume 66; Issue 12
1st December 1979
Authors: I. Taylor, J. Rowling, C. West
A comparative randomized trial of heparin versus streptokinase in the treatment of acute proximal venous thrombosis: An interim report of a prospective trial. BJS 1979; 66: 838-843.
Authors: M. S. Elliot, E. J. Immelman, P. Jeffery, S. R. Benatar, M. R. Funston, J. A. Smith et al.
Anticoagulant activity and operative blood loss after intrapulmonary heparin. BJS 1979; 66: 844-847.
Authors: Charles J. Wright, Jaysen Mahadoo, Louis B. Jaques
Circulating breast tumour antigen‐sensitive T lymphocytes in early breast cancer and high risk benign breast disease. BJS 1979; 66: 848-852.
Authors: William G. Ramey, George A. Hashim, Hugh F. Fitzpatrick
The distribution, size and density of the apocrine glands in hidradenitis suppuritiva. BJS 1979; 66: 853-856.
Authors: W. P. Morgan, L. E. Hughes
Continent anal ileostomy with mucosal proctectomy: A bloodless technique using a surgical ultrasonic aspirator in dogs. BJS 1979; 66: 857-860.
Authors: W. J. B. Hodgson, J. L. Finkelstein, Phillipa Woodriffe, A. H. Aufses
Modulation of the immune response and control of tumour spread by a new synthetic compound. BJS 1979; 66: 861-863.
Authors: R. E. Falk, L. Makowka, N. Nossal, J. A. Falk, J. E. Fields, S. S. Asculai et al.
Authors: N. Menzies Gow, J. P. S. Cochrane
Multi‐element analysis of the living body by neutron activation analysis—application to critically ill patients receiving intravenous nutrition. BJS 1979; 66: 868-872.
Authors: Graham L. Hill, Roderick F. G. J. King, Ross C. Smith, Alan H. Smith, Clement B. Oxby, Ali Sharafi et al.


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All of those who heard very first about online gambling could be impressed because is permitted to come about. It confuses lots of people when the live gambling inside the gambling is extremely intensely controlled then how could the online gambling arise? Is it lawful? This will depend if the online gambling is legit or possibly not. You can find 2 important rules of government linked to the net gambling. The initial guidelines produced a point of using cords for connections to the gambling functions. Nevertheless in 1961, lawmakers could not have envisioned the web. So whilst the website utilizes wire relationships the total notion of the word provided it a number of loopholes or possibly the flaws.
Therefore, another regulation was accredited that revolves around the World Wide Web gambling enterprise rather than regarding the gambler. It is regarded as a felony for almost any business to adopt any exclusive quantity of funds related to the web centered gambling. This is the firms with who you can do betting through web are situated beyond the US wherein there may be basically no hard criminal prosecution. However the Federal government also is expecting US banking institutions in order to avoid dollars from coming to the online businesses due to difficulties associated with the payout process of the United States credit accounts or banking institution cards. At present this concern is just not any much more there.
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882 South Matlack Street - Unit A, West Chester, PA, USA
Since 1950 American Arborist Supplies has equipped tree care professionals with top quality gear, supplies and equipment. Our large selection of ropes, climbing & rigging gear, arborist tools, plant health supplies and PPE, makes us the go to source for all things Arborist. ... Read more
Burnaby, BC, Canada
Arborist supply store, specializing in sarcasm and shiny stuff. Home to DarkArts Splicing, offering both sexy and custom rope works. Husqvarna sales and machinery repair shop. ... Read more
2121 Iron Street, Bellingham, WA, USA
(360) 734-5242(360) 734-5242
WesSpur is your source for the best arborist gear. From ropes and ascenders to safety gear and saws – we have your tree gear ready to go! Our warehouse in Bellingham ships gear all over the world and is open to the public from 7AM to 5PM, Monday-Friday. Our friendly customer service folks can get you exactly what you need for your next job. Check out the latest tree gear at WesS... Read more
6565 Coffman Road, Indianapolis, IN, USA
TreeStuff started as a tiny online store with a focus on innovation and customer service, and a dedication to making the tree care industry better. Now TreeStuff is the galaxy's largest online retailer of professional arborist equipment, but we've made sure to keep the small-town heart that has made us what we are today through a focus on the customer and the community. Tr... Read more
25 Worthington Drive, Brantford, ON, Canada
Proudly Canadian Worldwide Rope and Accessory Supplier Since 1982 Open Monday to Friday 8:30 -5:00 519-752-6642 http://www.mapleleafropes.com ... Read more
California Warehouse and Showroom
800 421 4833800 421 4833
Bishop Company is a distributor of Arborist and Landscaper Tools and Equipment. See http://www.bishco.com for our product collection or call us at 800 421 4833 and request our free catalog. ... Read more


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MEDFORD, Ore. -- Kid Time's Sunny Spicer joins NewsWatch 12 in the studio to talk about the nonprofit children's museum and discovery center.
To learn more about Kid Time Children's Museum, click here.
Related Content
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- Kid Time, YMCA Bus Vandalized in Medford
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- ScienceWorks Hands-On Museum
- A mom found videos on YouTube Kids that gave children instructions for suicide
- America's Best Kids can help you teach your children self-defense
- Gardening With Kids
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This list is updated daily and reflects the last month of access data. Articles older than two years will not be shown.
Electronic nicotine delivery systems (ENDS) or e-cigarettes have emerged as a popular recreational tool among adolescents and adults. Although the use of ENDS is often promoted as a safer alternative to conventional cigarettes, few comprehensive studies have assessed the long-term effects of vaporized nicotine and its associated solvents, propylene glycol (PG) and vegetable glycerin (VG). Here, we show that compared with smoke exposure, mice receiving ENDS vapor for 4 months failed to develop pulmonary inflammation or emphysema. However, ENDS exposure, independent of nicotine, altered lung lipid homeostasis in alveolar macrophages and epithelial cells. Comprehensive lipidomic and structural analyses of the lungs revealed aberrant phospholipids in alveolar macrophages and increased surfactant-associated phospholipids in the airway. In addition to ENDS-induced lipid deposition, chronic ENDS vapor exposure downregulated innate immunity against viral pathogens in resident macrophages. Moreover, independent of nicotine, ENDS-exposed mice infected with influenza demonstrated enhanced lung inflammation and tissue damage. Together, our findings reveal that chronic e-cigarette vapor aberrantly alters the physiology of lung epithelial cells and resident immune cells and promotes poor response to infectious challenge. Notably, alterations in lipid homeostasis and immune impairment are independent of nicotine, thereby warranting more extensive investigations of the vehicle solvents used in e-cigarettes.
Matthew C. Madison, Cameron T. Landers, Bon-Hee Gu, Cheng-Yen Chang, Hui-Ying Tung, Ran You, Monica J. Hong, Nima Baghaei, Li-Zhen Song, Paul Porter, Nagireddy Putluri, Ramiro Salas, Brian E. Gilbert, Ilya Levental, Matthew J. Campen, David B. Corry, Farrah Kheradmand
Total views: 19153
Parkinson's disease (PD) is a common neurodegenerative disease that lacks therapies to prevent progressive neurodegeneration. Impaired energy metabolism and reduced ATP levels are common features of PD. Previous studies revealed that terazosin (TZ) enhances the activity of phosphoglycerate kinase 1 (PGK1), thereby stimulating glycolysis and increasing cellular ATP levels. Therefore, we asked whether enhancement of PGK1 activity would change the course of PD. In toxin-induced and genetic PD models in mice, rats, flies, and induced pluripotent stem cells, TZ increased brain ATP levels and slowed or prevented neuron loss. The drug increased dopamine levels and partially restored motor function. Because TZ is prescribed clinically, we also interrogated 2 distinct human databases. We found slower disease progression, decreased PD-related complications, and a reduced frequency of PD diagnoses in individuals taking TZ and related drugs. These findings suggest that enhancing PGK1 activity and increasing glycolysis may slow neurodegeneration in PD.
Rong Cai, Yu Zhang, Jacob E. Simmering, Jordan L. Schultz, Yuhong Li, Irene Fernandez-Carasa, Antonella Consiglio, Angel Raya, Philip M. Polgreen, Nandakumar S. Narayanan, Yanpeng Yuan, Zhiguo Chen, Wenting Su, Yanping Han, Chunyue Zhao, Lifang Gao, Xunming Ji, Michael J. Welsh, Lei Liu
Total views: 7698
Nutrient excess, a major driver of obesity, diminishes hypothalamic responses to exogenously administered leptin, a critical hormone of energy balance. Here, we aimed to identify a physiological signal that arises from excess caloric intake and negatively controls hypothalamic leptin action. We found that deficiency of the gastric inhibitory polypeptide receptor (Gipr) for the gut-derived incretin hormone GIP protected against diet-induced neural leptin resistance. Furthermore, a centrally administered antibody that neutralizes GIPR had remarkable antiobesity effects in diet-induced obese mice, including reduced body weight and adiposity, and a decreased hypothalamic level of SOCS3, an inhibitor of leptin actions. In contrast, centrally administered GIP diminished hypothalamic sensitivity to leptin and increased hypothalamic levels of Socs3. Finally, we show that GIP increased the active form of the small GTPase Rap1 in the brain and that its activation was required for the central actions of GIP. Altogether, our results identify GIPR/Rap1 signaling in the brain as a molecular pathway linking overnutrition to the control of neural leptin actions.
Kentaro Kaneko, Yukiko Fu, Hsiao-Yun Lin, Elizabeth L. Cordonier, Qianxing Mo, Yong Gao, Ting Yao, Jacqueline Naylor, Victor Howard, Kenji Saito, Pingwen Xu, Siyu S. Chen, Miao-Hsueh Chen, Yong Xu, Kevin W. Williams, Peter Ravn, Makoto Fukuda
Total views: 2277
Polymerase δ is essential for eukaryotic genome duplication and synthesizes DNA at both the leading and lagging strands. The polymerase δ complex is a heterotetramer comprising the catalytic subunit POLD1 and the accessory subunits POLD2, POLD3, and POLD4. Beyond DNA replication, the polymerase δ complex has emerged as a central element in genome maintenance. The essentiality of polymerase δ has constrained the generation of polymerase δ–knockout cell lines or model organisms and, therefore, the understanding of the complexity of its activity and the function of its accessory subunits. To our knowledge, no germline biallelic mutations affecting this complex have been reported in humans. In patients from 2 independent pedigrees, we have identified what we believe to be a novel syndrome with reduced functionality of the polymerase δ complex caused by germline biallelic mutations in POLD1 or POLD2 as the underlying etiology of a previously unknown autosomal-recessive syndrome that combines replicative stress, neurodevelopmental abnormalities, and immunodeficiency. Patients' cells showed impaired cell-cycle progression and replication-associated DNA lesions that were reversible upon overexpression of polymerase δ. The mutations affected the stability and interactions within the polymerase δ complex or its intrinsic polymerase activity. We believe our discovery of human polymerase δ deficiency identifies the central role of this complex in the prevention of replication-related DNA lesions, with particular relevance to adaptive immunity.
Cecilia Domínguez Conde, Özlem Yüce Petronczki, Safa Baris, Katharina L. Willmann, Enrico Girardi, Elisabeth Salzer, Stefan Weitzer, Rico Chandra Ardy, Ana Krolo, Hanna Ijspeert, Ayca Kiykim, Elif Karakoc-Aydiner, Elisabeth Förster-Waldl, Leo Kager, Winfried F. Pickl, Giulio Superti-Furga, Javier Martínez, Joanna I. Loizou, Ahmet Ozen, Mirjam van der Burg, Kaan Boztug
Total views: 2170
Dengue virus (DENV) infection causes a characteristic pathology in humans involving dysregulation of the vascular system. In some patients with dengue hemorrhagic fever (DHF), vascular pathology can become severe, resulting in extensive microvascular permeability and plasma leakage into tissues and organs. Mast cells (MCs), which line blood vessels and regulate vascular function, are able to detect DENV in vivo and promote vascular leakage. Here, we showed that an MC-derived protease, tryptase, is consequential for promoting vascular permeability during DENV infection through inducing breakdown of endothelial cell tight junctions. Injected tryptase alone was sufficient to induce plasma loss from the circulation and hypovolemic shock in animals. A potent tryptase inhibitor, nafamostat mesylate, blocked DENV-induced vascular leakage in vivo. Importantly, in 2 independent human dengue cohorts, tryptase levels correlated with the grade of DHF severity. This study defines an immune mechanism by which DENV can induce vascular pathology and shock.
Abhay P.S. Rathore, Chinmay Kumar Mantri, Siti A.B. Aman, Ayesa Syenina, Justin Ooi, Cyril J. Jagaraj, Chi Ching Goh, Hasitha Tissera, Annelies Wilder-Smith, Lai Guan Ng, Duane J. Gubler, Ashley L. St. John
Total views: 1820
BACKGROUND Idiopathic multicentric Castleman disease (iMCD) is a hematologic illness involving cytokine-induced lymphoproliferation, systemic inflammation, cytopenias, and life-threatening multi-organ dysfunction. The molecular underpinnings of interleukin-6 (IL-6) blockade–refractory patients remain unknown; no targeted therapies exist. In this study, we searched for therapeutic targets in IL-6 blockade–refractory iMCD patients with the thrombocytopenia, anasarca, fever/elevated C-reactive protein, reticulin myelofibrosis, renal dysfunction, organomegaly (TAFRO) clinical subtype.METHODS We analyzed tissues and blood samples from 3 IL-6 blockade–refractory iMCD-TAFRO patients. Cytokine panels, quantitative serum proteomics, flow cytometry of PBMCs, and pathway analyses were employed to identify novel therapeutic targets. To confirm elevated mTOR signaling, a candidate therapeutic target from the above assays, immunohistochemistry was performed for phosphorylated S6, a read-out of mTOR activation, in 3 iMCD lymph node tissue samples and controls. Proteomic, immunophenotypic, and clinical response assessments were performed to quantify the effects of administration of the mTOR inhibitor sirolimus.RESULTS Studies of 3 IL-6 blockade–refractory iMCD cases revealed increased CD8+ T cell activation, VEGF-A, and PI3K/Akt/mTOR pathway activity. Administration of sirolimus substantially attenuated CD8+ T cell activation and decreased VEGF-A levels. Sirolimus induced clinical benefit responses in all 3 patients with durable and ongoing remissions of 66, 19, and 19 months.CONCLUSION This precision medicine approach identifies PI3K/Akt/mTOR signaling as the first pharmacologically targetable pathogenic process in IL-6 blockade–refractory iMCD. Prospective evaluation of sirolimus in treatment-refractory iMCD is planned (NCT03933904).FUNDING This study was supported by the Castleman's Awareness & Research Effort/Castleman Disease Collaborative Network, Penn Center for Precision Medicine, University Research Foundation, Intramural NIH funding, and the National Heart Lung and Blood Institute.
David C. Fajgenbaum, Ruth-Anne Langan, Alberto Sada Japp, Helen L. Partridge, Sheila K. Pierson, Amrit Singh, Daniel J. Arenas, Jason R. Ruth, Christopher S. Nabel, Katie Stone, Mariko Okumura, Anthony Schwarer, Fábio Freire Jose, Nelson Hamerschlak, Gerald B. Wertheim, Michael B. Jordan, Adam D. Cohen, Vera Krymskaya, Arthur Rubenstein, Michael R. Betts, Taku Kambayashi, Frits van Rhee, Thomas S. Uldrick
Total views: 1818
Persistent, unresolved inflammation in the liver represents a key trigger for hepatic injury and fibrosis in various liver diseases and is controlled by classically activated proinflammatory macrophages, while restorative macrophages of the liver are capable of reversing inflammation once the injury trigger ceases. Here we exhibit neutrophils as key contributors to resolving the inflammatory response in the liver using two models of liver inflammation resolution. Using two models of liver inflammatory resolution, we found that mice undergoing neutrophil depletion during the resolution phase exhibited unresolved hepatic inflammation, activation of the fibrogenic machinery, and early fibrosis. These findings were associated with an impairment of the phenotypic switch of proinflammatory macrophages into a restorative stage after removal of the cause of injury and an increased NLRP3/miR-223 ratio. Mice with a deletion of the granulocyte-specific miR-223 gene showed a similarly impaired resolution profile that could be reversed by replacing miR-223 levels using a miR-223 3p mimic or by infusion of neutrophils from wild-type animals. Collectively, our findings reveal hepatic neutrophils as resolving effector cells that induce proinflammatory macrophages into a restorative phenotype, potentially via miR-223.
Carolina Jimenez Calvente, Masahiko Tameda, Casey D. Johnson, Hana del Pilar, Yun Chin Lin, Nektaria Adronikou, Xavier De Mollerat Du Jeu, Cristina Llorente, Josh Boyer, Ariel E. Feldstein
Total views: 1747
Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening hypoglycemia during starvation-like conditions, but do not consistently exhibit overt metabolic phenotypes when given ad libitum food access. These results, and findings of ghrelin resistance in obese states, imply nutritional state dependence of ghrelin's metabolic actions. Here, we hypothesized that liver-enriched antimicrobial peptide-2 (LEAP2), a recently characterized endogenous GHSR antagonist, blunts ghrelin action during obese states and postprandially. To test this hypothesis, we determined changes in plasma LEAP2 and acyl-ghrelin due to fasting, eating, obesity, Roux-en-Y gastric bypass (RYGB), vertical sleeve gastrectomy (VSG), oral glucose administration, and type 1 diabetes mellitus (T1DM) using humans and/or mice. Our results suggest that plasma LEAP2 is regulated by metabolic status: its levels increased with body mass and blood glucose and decreased with fasting, RYGB, and in postprandial states following VSG. These changes were mostly opposite of those of acyl-ghrelin. Furthermore, using electrophysiology, we showed that LEAP2 both hyperpolarizes and prevents acyl-ghrelin from activating arcuate NPY neurons. We predict that the plasma LEAP2/acyl-ghrelin molar ratio may be a key determinant modulating acyl-ghrelin activity in response to body mass, feeding status, and blood glucose.
Bharath K. Mani, Nancy Puzziferri, Zhenyan He, Juan A. Rodriguez, Sherri Osborne-Lawrence, Nathan P. Metzger, Navpreet Chhina, Bruce Gaylinn, Michael O. Thorner, E. Louise Thomas, Jimmy D. Bell, Kevin W. Williams, Anthony P. Goldstone, Jeffrey M. Zigman
Total views: 1702
While a high frequency of Th1 cells in tumors is associated with improved cancer prognosis, this benefit has been attributed mainly to support of cytotoxic activity of CD8+ T cells. By attempting to potentiate antibody-driven immunity, we found a remarkable synergy between CD4+ T cells and tumor-binding antibodies. This surprising synergy was mediated by a small subset of tumor-infiltrating CD4+ T cells that express the high-affinity Fcγ receptor for IgG (FcγRI) in both mouse and human patients. These cells efficiently lyse tumor cells coated with antibodies through concomitant crosslinking of their T cell receptor (TCR) and FcγRI. By expressing FcγRI and its signaling chain in conventional CD4+ T cells, we successfully employed this mechanism to treat established solid cancers. Overall, this discovery sheds new light on the biology of this T cell subset, their function during tumor immunity, and the means to utilize their unique killing signals in immunotherapy.
Diana Rasoulouniriana, Nadine Santana-Magal, Amit Gutwillig, Leen Farhat-Younis, Yariv Wine, Corey Saperia, Lior Tal, Haim Gutman, Alexander Tsivian, Ronen Brenner, Eiman Abu Bandora, Nathan E. Reticker-Flynn, Peleg Rider, Yaron Carmi
Total views: 1618
Despite recent therapeutic advances, prostate cancer remains a leading cause of cancer-related death. A subset of castration-resistant prostate cancers become androgen receptor (AR) signaling independent and develop neuroendocrine prostate cancer (NEPC) features through lineage plasticity. These NEPC tumors, associated with aggressive disease and poor prognosis, are driven, in part, by aberrant expression of N-Myc, through mechanisms that remain unclear. Integrative analysis of the N-Myc transcriptome, cistrome, and interactome using in vivo, in vitro, and ex vivo models (including patient-derived organoids) identified a lineage switch towards a neural identity associated with epigenetic reprogramming. N-Myc and known AR cofactors (e.g., FOXA1 and HOXB13) overlapped, independently of AR, at genomic loci implicated in neural lineage specification. Moreover, histone marks specifically associated with lineage-defining genes were reprogrammed by N-Myc. We also demonstrated that the N-Myc–induced molecular program accurately classifies our cohort of patients with advanced prostate cancer. Finally, we revealed the potential for enhancer of zeste homolog 2 (EZH2) inhibition to reverse the N-Myc–induced suppression of epithelial lineage genes. Altogether, our data provide insights into how N-Myc regulates lineage plasticity and epigenetic reprogramming associated with lineage specification. The N-Myc signature we defined could also help predict the evolution of prostate cancer and thus better guide the choice of future therapeutic strategies.
Adeline Berger, Nicholas J. Brady, Rohan Bareja, Brian Robinson, Vincenza Conteduca, Michael A. Augello, Loredana Puca, Adnan Ahmed, Etienne Dardenne, Xiaodong Lu, Inah Hwang, Alyssa M. Bagadion, Andrea Sboner, Olivier Elemento, Jihye Paik, Jindan Yu, Christopher E. Barbieri, Noah Dephoure, Himisha Beltran, David S. Rickman
Total views: 1576
Vaccine development against tuberculosis (TB) is based on the induction of adaptive immune responses endowed with long-term memory against mycobacterial antigens. Memory B and T cells initiate a rapid and robust immune response upon encounter with Mycobacterium tuberculosis, thus achieving long-lasting protection against infection. Recent studies have shown, however, that innate immune cell populations such as myeloid cells and NK cells also undergo functional adaptation after infection or vaccination, a de facto innate immune memory that is also termed trained immunity. Experimental and epidemiological data have shown that induction of trained immunity contributes to the beneficial heterologous effects of vaccines such as bacille Calmette-Guérin (BCG), the licensed TB vaccine. Moreover, increasing evidence argues that trained immunity also contributes to the anti-TB effects of BCG vaccination. An interaction among immunological signals, metabolic rewiring, and epigenetic reprogramming underlies the molecular mechanisms mediating trained immunity in myeloid cells and their bone marrow progenitors. Future studies are warranted to explore the untapped potential of trained immunity to develop a future generation of TB vaccines that would combine innate and adaptive immune memory induction.
Shabaana A. Khader, Maziar Divangahi, Willem Hanekom, Philip C. Hill, Markus Maeurer, Karen W. Makar, Katrin D. Mayer-Barber, Musa M. Mhlanga, Elisa Nemes, Larry S. Schlesinger, Reinout van Crevel, Ramakrishna Vankalayapati, Ramnik J. Xavier, Mihai G. Netea, on behalf of the Bill and Melinda Gates Foundation Collaboration for TB Vaccine Discovery Innate Immunity Working Group18
Total views: 2969
Natural killer (NK) cells are innate cytotoxic lymphocytes involved in the surveillance and elimination of cancer. As we have learned more and more about the mechanisms NK cells employ to recognize and eliminate tumor cells, and how, in turn, cancer evades NK cell responses, we have gained a clear appreciation that NK cells can be harnessed in cancer immunotherapy. Here, we review the evidence for NK cells' critical role in combating transformed and malignant cells, and how cancer immunotherapies potentiate NK cell responses for therapeutic purposes. We highlight cutting-edge immunotherapeutic strategies in preclinical and clinical development such as adoptive NK cell transfer, chimeric antigen receptor–expressing NK cells (CAR-NKs), bispecific and trispecific killer cell engagers (BiKEs and TriKEs), checkpoint blockade, and oncolytic virotherapy. Further, we describe the challenges that NK cells face (e.g., postsurgical dysfunction) that must be overcome by these therapeutic modalities to achieve cancer clearance.
Jonathan J. Hodgins, Sarwat T. Khan, Maria M. Park, Rebecca C. Auer, Michele Ardolino
Total views: 2856
Adipose tissue plays important roles in regulating whole-body energy metabolism through its storage function in white adipocytes and its dissipating function in brown and beige adipocytes. Adipose tissue also produces a variety of secreted factors called adipocytokines, including leptin and adiponectin. Furthermore, recent studies have suggested the important roles of extracellular vesicles of endosomal origin termed exosomes, which are secreted from adipocytes and other cells in adipose tissue and influence whole-body glucose and lipid metabolism. Adiponectin is known to be a pleiotropic organ-protective protein that is exclusively produced by adipocytes and decreased in obesity. Adiponectin accumulates in tissues such as heart, muscle, and vascular endothelium through binding with T-cadherin, a glycosylphosphatidylinositol-anchored (GPI-anchored) cadherin. Recently, adiponectin was found to enhance exosome biogenesis and secretion, leading to a decrease in cellular ceramides, excess of which is known to cause insulin resistance and cardiovascular disease phenotypes. These findings support the hypothesis that adipose tissue metabolism systemically regulates exosome production and whole-body metabolism through exosomes. This review focuses on intra-adipose and interorgan communication by exosomes, adiponectin-stimulated exosome production, and their dysregulation in metabolic diseases.
Shunbun Kita, Norikazu Maeda, Iichiro Shimomura
Total views: 1886
Although obesity is typically associated with metabolic dysfunction and cardiometabolic diseases, some people with obesity are protected from many of the adverse metabolic effects of excess body fat and are considered "metabolically healthy." However, there is no universally accepted definition of metabolically healthy obesity (MHO). Most studies define MHO as having either 0, 1, or 2 metabolic syndrome components, whereas many others define MHO using the homeostasis model assessment of insulin resistance (HOMA-IR). Therefore, numerous people reported as having MHO are not metabolically healthy, but simply have fewer metabolic abnormalities than those with metabolically unhealthy obesity (MUO). Nonetheless, a small subset of people with obesity have a normal HOMA-IR and no metabolic syndrome components. The mechanism(s) responsible for the divergent effects of obesity on metabolic health is not clear, but studies conducted in rodent models suggest that differences in adipose tissue biology in response to weight gain can cause or prevent systemic metabolic dysfunction. In this article, we review the definition, stability over time, and clinical outcomes of MHO, and discuss the potential factors that could explain differences in metabolic health in people with MHO and MUO — specifically, modifiable lifestyle factors and adipose tissue biology. Better understanding of the factors that distinguish people with MHO and MUO can produce new insights into mechanism(s) responsible for obesity-related metabolic dysfunction and disease.
Gordon I. Smith, Bettina Mittendorfer, Samuel Klein
Total views: 1755
IgG antibodies are secreted from B cells and bind to a variety of pathogens to control infections as well as contribute to inflammatory diseases. Many of the functions of IgGs are mediated through Fcγ receptors (FcγRs), which transduce interactions with immune complexes, leading to a variety of cellular outcomes depending on the FcγRs and cell types engaged. Which FcγRs and cell types will be engaged during an immune response depends on the structure of Fc domains within immune complexes that are formed when IgGs bind to cognate antigen(s). Recent studies have revealed an unexpected degree of structural variability in IgG Fc domains among people, driven primarily by differences in IgG subclasses and N-linked glycosylation of the CH2 domain. This translates, in turn, to functional immune diversification through type I and type II FcγR–mediated cellular functions. For example, Fc domain sialylation triggers conformational changes of IgG1 that enable interactions with type II FcγRs; these receptors mediate cellular functions including antiinflammatory activity or definition of thresholds for B cell selection based on B cell receptor affinity. Similarly, presence or absence of a core fucose alters type I FcγR binding of IgG1 by modulating the Fc's affinity for FcγRIIIa, thereby altering its proinflammatory activity. How heterogeneity in IgG Fc domains contributes to human immune diversity is now being elucidated, including impacts on vaccine responses and susceptibility to disease and its sequelae during infections. Here, we discuss how Fc structures arising from sialylation and fucosylation impact immunity, focusing on responses to vaccination and infection. We also review work defining individual differences in Fc glycosylation, regulation of Fc glycosylation, and clinical implications of these pathways.
Taia T. Wang, Jeffrey V. Ravetch
Total views: 1678
In a society where physical activity is limited and food supply is abundant, metabolic diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster of metabolically related symptoms such as obesity, hypertension, dyslipidemia, and carbohydrate intolerance, and significantly increases type 2 diabetes mellitus risk. Insulin resistance and hyperinsulinemia are consistent characteristics of MetS, but which of these features is the initiating insult is still widely debated. Regardless, both of these conditions trigger adverse responses from the pancreatic β cell, which is responsible for producing, storing, and releasing insulin to maintain glucose homeostasis. The observation that the degree of β cell dysfunction correlates with the severity of MetS highlights the need to better understand β cell dysfunction in the development of MetS. This Review focuses on the current understanding from rodent and human studies of the progression of β cell responses during the development of MetS, as well as recent findings addressing the complexity of β cell identity and heterogeneity within the islet during disease progression. The differential responses observed in β cells together with the heterogeneity in disease phenotypes within the patient population emphasize the need to better understand the mechanisms behind β cell adaptation, identity, and dysfunction in MetS.
Laura I. Hudish, Jane E.B. Reusch, Lori Sussel
Total views: 1631
Patients with type 1 or type 2 diabetes have an insufficiency in their functional β cell mass. To advance diabetes treatment and to work toward a cure, a better understanding of how to protect the pancreatic β cells against autoimmune or metabolic assaults (e.g., obesity, gestation) will be required. Over the past decades, β cell protection has been extensively investigated in rodents both in vivo and in vitro using isolated islets or rodent β cell lines. Transferring these rodent data to humans has long been challenging, at least partly for technical reasons: primary human islet preparations were scarce and functional human β cell lines were lacking. In 2011, we described a robust protocol of targeted oncogenesis in human fetal pancreas and produced the first functional human β cell line, and in subsequent years additional lines with specific traits. These cell lines are currently used by more than 150 academic and industrial laboratories worldwide. In this Review, we first explain how we developed the human β cell lines and why we think we succeeded where others, despite major efforts, did not. Next, we discuss the use of such functional human β cell lines and share some perspectives on their use to advance diabetes research.
Raphael Scharfmann, Willem Staels, Olivier Albagli
Total views: 1358
Development of novel and effective therapeutics for treating various cancers is probably the most congested and challenging enterprise of pharmaceutical companies. Diverse drugs targeting malignant and nonmalignant cells receive clinical approval each year from the FDA. Targeting cancer cells and nonmalignant cells unavoidably changes the tumor microenvironment, and cellular and molecular components relentlessly alter in response to drugs. Cancer cells often reprogram their metabolic pathways to adapt to environmental challenges and facilitate survival, proliferation, and metastasis. While cancer cells' dependence on glycolysis for energy production is well studied, the roles of adipocytes and lipid metabolic reprogramming in supporting cancer growth, metastasis, and drug responses are less understood. This Review focuses on emerging mechanisms involving adipocytes and lipid metabolism in altering the response to cancer treatment. In particular, we discuss mechanisms underlying cancer-associated adipocytes and lipid metabolic reprogramming in cancer drug resistance.
Yihai Cao
Total views: 1191
The distribution of telomere length in humans is broad, but it has finite upper and lower boundaries. Growing evidence shows that there are disease processes that are caused by both short and long telomere length extremes. The genetic basis of these short and long telomere syndromes may be linked to mutations in the same genes, such as the telomerase reverse transcriptase (TERT), but through differential effects on telomere length. Short telomere syndromes have a predominant degenerative phenotype marked by organ failure that most commonly manifests as pulmonary fibrosis and are associated with a relatively low cancer incidence. In contrast, insights from studies of cancer-prone families as well as genome-wide association studies (GWAS) have identified both rare and common variants that lengthen telomeres as being strongly associated with cancer risk. We have hypothesized that these cancers represent a long telomere syndrome that is associated with a high penetrance of cutaneous melanoma and chronic lymphocytic leukemia. In this Review, we will synthesize the clinical and human genetic observations with data from mouse models to define the role of telomeres in cancer etiology and biology.
Emily J. McNally, Paz J. Luncsford, Mary Armanios
Total views: 1127
Cellular senescence is a highly stable cell cycle arrest that is elicited in response to different stresses. By imposing a growth arrest, senescence limits the replication of old or damaged cells. Besides exiting the cell cycle, senescent cells undergo many other phenotypic alterations such as metabolic reprogramming, chromatin rearrangement, or autophagy modulation. In addition, senescent cells produce and secrete a complex combination of factors, collectively referred as the senescence-associated secretory phenotype, that mediate most of their non–cell-autonomous effects. Because senescent cells influence the outcome of a variety of physiological and pathological processes, including cancer and age-related diseases, pro-senescent and anti-senescent therapies are actively being explored. In this Review, we discuss the mechanisms regulating different aspects of the senescence phenotype and their functional implications. This knowledge is essential to improve the identification and characterization of senescent cells in vivo and will help to develop rational strategies to modulate the senescence program for therapeutic benefit.
Nicolás Herranz, Jesús Gil
Total views: 1067


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7 Of The Best Fruits For Diabetics (based On Sugar And Nutrients)
Fruits are the perfect snack. They are loaded with nutrients and fiber, relatively low in calories, and easy to bring to work. However, they do contain naturally occurring sugars, sometimes in large amounts. This can be a concern for those who struggle to manage their blood sugars. This article takes a science-based look at the most suitable fruits for diabetics. 1. Blueberries Blueberries are quite low in sugar, with 10 grams per 100 grams of fruit (1). But that sugar is also accompanied by 2 grams of fiber. This is important because when sugar and fiber are eaten together, blood sugar levels don't spike as quickly (2, 3). It's the reason 10 grams of sugar from fresh fruits will not have the same effect on blood sugar levels as 10 grams of sugar from a candy bar. In addition, blueberries provide loads of other beneficial nutrients and antioxidants that protect our cells from damage. Interestingly, a study on over 187,000 people tracked over two decades found those who ate the most blueberries had more than a 25% lower risk of getting diabetes than those who ate the fewest (4). Blueberries are great for a snack, and you can even enjoy them in salads. Although they can be particularly expensive, know that frozen blueberries are still nutritious and often much more affordable. 2. Strawberries Strawberries contain even less sugar than blueberries, with only 5 grams per 100 grams of fruit (5). This makes them a great choice for diabetics. They also provide fiber, manganese, folate, and a lot of vitamin C. In fact, 100 grams of strawberries (5-6 large strawberries) provides 98% of our daily vitamin C requirements. Strawberries are a great addition to breakfast foods like oats or yogurt, but they are also delicious on their own. 3. Blackberries Blackberries stand out as n Continue reading >>
Fruit For Diabetes – Is It Actually Safe To Eat?
If you are living with diabetes, you've probably been told to minimize or eliminate your intake of fruit because "fruit is high in sugar." And if this is the case, maybe you refrain from eating fruits because it causes your blood glucose to spike. Attracted by the smell, color and taste, you may find yourself asking a simple question: "Should I avoid fruit in the long-term? And if so, will I ever be able to eat fruit again?" It turns out that this ant-fruit message is a perfect example of pseudoscience at its best. A recent study published in PLOS medicine tracked the health of 512,891 Chinese men and women between the ages of 30 and 79 for an average of 7 years, in order to understand the effect that their diet had on their overall health (1). We like these types of studies because they are: For those who did not have diabetes at the beginning of the study, those who had a higher fruit consumption were 12% less likely to develop diabetes, compared with those who ate zero pieces of fruit per day. The researchers found a dose-response relationship, which means that the more frequently these nondiabetic individuals ate fruit, the lower the risk for developing diabetes. Amongst those living with diabetes at the beginning of the study, those who ate fruit 3 times per week reduced their risk of all-cause mortality (death from any cause) by 17%, compared with diabetic individuals who ate zero pieces of fruit per day. In addition, researchers uncovered that those who ate fresh fruit 3 days per week were 13-28% less likely to experience macrovascular complications (heart disease and stroke) and microvascular damage (kidney disease, retinopathy and neuropathy). Even though this study was observational, the results of the study have profound implications for people living with Continue reading >>
25 Best Fruits For Diabetics
Are you a diabetic? Are you worried about foods with a high glycemic index? Don't worry. We are here to give you the best fruits that you can relish without worrying about your blood sugar levels. Would you like to know more? Keep reading! Diet For Diabetics: Diabetics do not have to eliminate all sugary foods from their regular meals. Sugar or glucose is a vital requirement for the human body. It fuels us with energy so that we can stay active all day. But when you have to deal with diabetes, it is necessary to take care of your sweet cravings in an appropriate manner. Hence, portion control is essential for every diabetic. So, what would be the best practical way to ensure diabetics get their required intake of sugar? Fruits: The Ultimate Food For Diabetics: Most would prefer a healthier and natural way, and what better way is there to go with than fruits! A quick light snack, an after meal desert, or simply blended and squeezed into a refreshing drink, fruits can be consumed in many ways. Fruits also provide us with roughage, antioxidants, vitamins and minerals. But how would fruits benefit a diabetic? Well, in addition to the various nutrients fruits give, the simple sugars or carbs in them are a whole lot easier for the body to process. Also, these are the healthier kind of sugars the body needs. Diabetes may cause weight loss, resulting in severe health adversities. Including fruits in their diet regimen can contribute towards reducing the excessive weight of many diabetics. One of the effects of diabetes is that it makes people hungry all the time, and the intake of certain fruits can create the feeling of fullness. Again, too much of anything can prove to be bad for you. Thus, when consuming fruits, a diabetic must be cautious and careful while picking the fru Continue reading >>
8 Best Fruits For A Diabetes-friendly Diet
1 / 9 What Fruit Is Good for High Blood Sugar? When you're looking for a diabetes-friendly treat that can help keep your blood sugar within a healthy range, look no farther than the produce drawer of your refrigerator or the fruit basket on your kitchen table. Believe it or not, the notion that fruit is not safe when you need to watch your A1C is a popular diabetes myth that has been debunked again and again. Indeed, according to the American Diabetes Association (ADA), many types of fruit are loaded with good-for-you vitamins and minerals, as well as fiber — a powerful nutrient that can help regulate blood sugar levels and decrease your risk of developing type 2 diabetes, according to the Harvard T.H. Chan School of Public Health. Fiber — which can also be found in some of the best vegetables for diabetes, as well as whole grains — can further benefit your health because it promotes feelings of fullness, curbing unhealthy cravings and overeating, research shows. Healthy weight maintenance can increase your insulin sensitivity and help in your diabetes management. So, how do you pick the best fruit for diabetes? While some forms of fruit, like juice, can be bad for diabetes, whole fruits like berries, citrus, apricots, and yes, even apples — can be good for your A1C and overall health, fighting inflammation, normalizing your blood pressure, and more. But as with any food in your diabetes diet, you have to be smart about counting carbohydrates and tracking what you eat. Portion size is key. Consume fruit in its whole, natural form, and avoid syrups or any processed fruits with added sugar, which have the tendency to spike your blood sugar. Stick to the produce aisle and the freezer section of your grocery store. If you're using the glycemic index (GI) or glycemic Continue reading >>
13 Best And Worst Foods For People With Diabetes
How to choose food If you have diabetes, watching what you eat is one of the most important things you can do to stay healthy. "The basic goal of nutrition for people with diabetes is to avoid blood sugar spikes," says Gerald Bernstein, M.D., director of the diabetes management program at Friedman Diabetes Institute, Beth Israel Medical Center in New York. Candy and soda can be dangerous for diabetics because the body absorbs these simple sugars almost instantly. But all types of carbs need to be watched, and foods high in fat—particularly unhealthy fats—are problematic as well because people with diabetes are at very high risk of heart disease, says Sandy Andrews, RD, director of education for the William Sansum Diabetes Center in Santa Barbara, Calif. Worst: White rice The more white rice you eat, the greater your risk of type 2 diabetes, according to a 2012 review. In a study of more than 350,000 people, those who ate the most white rice were at greatest risk for type 2 diabetes, and the risk increased 11% for each additional daily serving of rice. "Basically anything highly processed, fried, and made with white flour should be avoided," says Andrews. White rice and pasta can cause blood sugar spikes similar to that of sugar. Have this instead: Brown rice or wild rice. These whole grains don't cause the same blood sugar spikes thanks to fiber, which helps slow the rush of glucose into the bloodstream, says Andrews. What's more, a Harvard School of Public Health study found that two or more weekly servings of brown rice was linked to a lower diabetes risk. Worst: Blended coffees Blended coffees that are laced with syrup, sugar, whipped cream, and other toppings can have as many calories and fat grams as a milkshake, making them a poor choice for those with diabete Continue reading >>
9 Of The Worst Eating Habits For Diabetes
You're a breakfast skipper istock/ShotShare We always hear that breakfast is the most important meal of the day, but this may be particularly true for individuals with diabetes, says Alison Massey, RD, a registered dietitian and director of diabetes education at Mercy Medical Center in Baltimore, Maryland. Waiting too long to eat in the morning might result in hypoglycemia or blood glucose that is too low. Here are tricks to treat hypoglycemia every diabetic should know. "Even when my clients aren't typical 'breakfast eaters,' I encourage them to incorporate a small snack into their morning routine, like a Greek yogurt with some berries or a hard-boiled egg and slice of whole grain toast," she says. It doesn't have to be a sit-down meal, but make sure you have something healthy in your body so you don't crash. Follow these healthy breakfast rules for diabetics. istock/GMVozd Research suggests that excessive fat intake (more than 30 percent of total calories) may worsen insulin resistance. Stay away from meals that tend to contain high amounts of saturated fat, like those from fast food restaurants. While the mechanism isn't clearly understood, some research has found a modest benefit in monounsaturated fatty acids (MUFAs) on insulin resistance, as well as decreasing liver fat. MUFAs are good-for-you fats found in avocados, olive oil, nut butters, and seeds, to name a few. A diet that is high in MUFAs and lower in saturated fats is also associated with improvements in cardiovascular health, lower LDL cholesterol, and reduced triglycerides and blood pressure, says Massey. Here are clear signs you aren't eating enough healthy fats. From Merrill Lynch istock/alle12 Overindulging in protein could impact your blood glucose levels, especially if that protein Continue reading >>
50 Best Foods For Diabetes
For most of us, dialing back on sugar and simple carbs is an effective way to fast-track weight loss. But for those living with diabetes, it can be a matter of life and death. Diabetics are two to four times more likely than people without diabetes to die of heart disease or experience a life-threatening stroke, according to the American Heart Association. And for those who don't properly control their condition, the odds of health issues—which range from cardiovascular trouble to nerve damage and kidney disease—increases exponentially. Luckily there are plenty of delicious foods that are compatible with diabetes. We tapped registered dietitians and certified diabetes educators for their top food picks that are low-carb and low-sugar, but still high in flavor. These superfoods will keep your blood sugar in check without skimping on flavor. Bonus: Most of these foods are also packed with essential vitamins and antioxidants to fight off inflammation and keep your energy levels high. While you're stocking up your grocery cart with these staples, be sure to avoid the 75 Unhealthiest Foods on the Planet. This nutty, trendy whole grain is a good source of fiber and protein, making it a smart pick for a diabetes diet, Sarah Koszyk, RDN tells us. "With the fiber and protein combination found in quinoa, you'll feel fuller and have better blood sugar control. Protein also helps with the uptake of carbohydrates so the body can process them more easily. I suggest enjoying quinoa in a salad or casserole." Elizabeth Snyder, RD, CDE says you can still eat carbs if you're diabetic. You just have to watch out for portion sizes: "The trouble [with eating carbs as a diabetic] lies in eating more carbohydrates than we need, as the body will choose to store any extra energ Continue reading >>
The 16 Best Foods To Control Diabetes
Figuring out the best foods to eat when you have diabetes can be tough. The main goal is to keep blood sugar levels well-controlled. However, it's also important to eat foods that help prevent diabetes complications like heart disease. Here are the 16 best foods for diabetics, both type 1 and type 2. Fatty fish is one of the healthiest foods on the planet. Salmon, sardines, herring, anchovies and mackerel are great sources of the omega-3 fatty acids DHA and EPA, which have major benefits for heart health. Getting enough of these fats on a regular basis is especially important for diabetics, who have an increased risk of heart disease and stroke (1). DHA and EPA protect the cells that line your blood vessels, reduce markers of inflammation and improve the way your arteries function after eating (2, 3, 4, 5). A number of observational studies suggest that people who eat fatty fish regularly have a lower risk of heart failure and are less likely to die from heart disease (6, 7). In studies, older men and women who consumed fatty fish 5–7 days per week for 8 weeks had significant reductions in triglycerides and inflammatory markers (8, 9). Fish is also a great source of high-quality protein, which helps you feel full and increases your metabolic rate (10). Fatty fish contain omega-3 fats that reduce inflammation and other risk factors for heart disease and stroke. Leafy green vegetables are extremely nutritious and low in calories. They're also very low in digestible carbs, which raise your blood sugar levels. Spinach, kale and other leafy greens are good sources of several vitamins and minerals, including vitamin C. In one study, increasing vitamin C intake reduced inflammatory markers and fasting blood sugar levels for people with type 2 diabetes or high blood pressure Continue reading >>
Diabetes Diet: Should I Avoid Sweet Fruits?
I've heard that you shouldn't eat sweet fruits such as strawberries or blueberries if you have diabetes. Is this true? Answers from M. Regina Castro, M.D. It's a common myth that if you have diabetes you shouldn't eat certain foods because they're "too sweet." Some fruits do contain more sugar than others, but that doesn't mean you shouldn't eat them if you have diabetes. The total amount of carbohydrates in a food affects blood sugar levels more than does the source of carbohydrates or whether the source is a starch or sugar. One serving of fruit should contain 15 grams of carbohydrates. The size of the serving depends on the carbohydrate content of the fruit. The advantage of eating a low-carbohydrate fruit is that you can consume a larger portion. But whether you eat a low-carb or high-carb fruit, as long as the serving size contains 15 grams of carbohydrates, the effect on your blood sugar is the same. The following fruit servings contain about 15 grams of carbohydrates: 1/2 medium apple or banana 1 cup blackberries 3/4 cup blueberries 1 cup raspberries 1 1/4 cup whole strawberries 1 cup cubed cantaloupe or honeydew melon Continue reading >>
15 Of The Best Foods For Diabetics, According To Science
High in soluble fiber, oats are slower to digest than processed carbs. Eat them and you'll release glucose into the bloodstream more slowly, which will prevent spikes in your blood-sugar levels. In a 2012 study from Sweden's Karolinska University, researchers found that eating four servings of whole grains daily reduced the risk for developing prediabetes by 30 percent. Other research shows that if you eat whole grains you experience less inflammation, which could lower the odds of your developing insulin resistance, heart disease, and high blood pressure. These science-backed strategies can work to reverse diabetes. This sweet seasoning contains a compound called hydroxychalcone, which may stimulate insulin receptors on cells and, in turn, improve your body's ability to absorb blood sugar. Researchers from the University of California-Davis recently reviewed eight different studies on cinnamon and reported that about half to one teaspoon a day lowered fasting blood sugar levels by an average of nine points among people with diabetes. Sprinkle the fragrant spice onto oatmeal or add a dash to a cup of coffee. These myths about diabetes could be damaging your health. From Merrill Lynch Eating more whole fruits, particularly grapes, blueberries, and apples, was significantly associated with a lower risk of type 2 diabetes, according to a Harvard study published in the British Medical Journal in 2013. People who ate at least two servings each week of certain whole fruits reduced their risk for type 2 diabetes by as much as 23 percent when compared to those who ate less than one serving per month. Eating the whole fruit seems to be key, though; researchers found that fruit juice drinkers faced as much as a 21 percent increased risk of developing diabetes. Make sure to Continue reading >>
10 Diabetic Friendly Fruits To Help You Manage Diabetes Better
Diabetes mellitus (DM) commonly referred to as Diabetes, is a chronic disorder. It occurs when the pancreas does not secrete enough insulin or when the cells of the body become resistant to insulin. In either case, the blood sugar cannot get into the cells for storage, which then leads to serious complications. Diabetes, perhaps more than any other disease, is strongly associated with the western diet, as it was uncommon in cultures consuming a 'primitive diet'. However as cultures switch from their native diets, to the foods of commerce; their rate of diabetes increases eventually reaching the proportions seen in the western societies. However, what's alarming is the fact that India Is home to 62 million diabetics and the number is estimated to be 100 million by 2030. Obesity is seen as one of the major contributing factors to the development of insulin resistance in approximately 90% of the individuals with type-2 diabetes. In most cases, achieving ideal body weight is associated with the restoration of normal blood sugar levels. Hence dietary modifications and treatment are fundamental to the successful treatment of both type 1 and type 2 diabetes. There are some specific foods that have been shown to produce positive effects on blood sugar control. These foods have a low glycemic index and glycemic load and are high in fiber. When it comes to diabetics eating fruits, there is a lot of confusion and information is very misleading. Just remember that moderation is the key here. TIPS TO ENJOY FRUITS IF YOU ARE DIABETIC: - Always eat fruits that are fresh, local and in season. - Eat fruits that have a low glycemic index. - Fruits should not be eaten with your main meals, its best to have fruits in between meals and as a snack. - Fruits with high glycemic index should be Continue reading >>
Fruit For A Diabetes Diet: What To Know Before You Snack
People with type 2 diabetes know that they need to pay attention to their carbohydrate intake. Of the three main macronutrients in food — protein, fat, and carbohydrates — it's the carbohydrates that directly affect blood sugar levels, and this includes the carbohydrates in fruit. But a study published in August 2013 in the British Medical Journal looked at the association between fruit and type 2 diabetes and found that fruit can still be a crucial part of a good diabetes diet. The study, which followed nearly 190,000 people over a number of years, found that eating whole fruits — especially blueberries, grapes, and apples — significantly reduces the risk for type 2 diabetes. On the flip side, drinking more fruit juices actually increases the risk for diabetes. "If you have type 2 diabetes, you do need to watch your sugar," says Katie Barbera, RD, CDE, of Northwell Health Systems in New Hyde Park, New York. She explains that while both whole fruit and fruit juice have carbohydrates, a small piece of whole fruit is equal to about 4 ounces (oz) of fruit juice. So if you drink 12 oz of fruit juice, you could be getting more than you need. "And whole fruits have a lot of other advantages for a diabetes diet," Barbera adds. Understanding the Carbohydrates in Fruit Like vegetables and grains, fruits contain carbs. You need the fruits for a healthy diet, but with type 2 diabetes you also need to keep track of the carbs. Still, figuring out which fruits are best for diabetes is about more than counting carbs — it's also important to take into account the beneficial nutrients certain fruits provide. "Whole fruits are an excellent source of antioxidants," Barbera says. "They have a lot of fiber, so they make you feel fuller and satisfy your hunger. They also add Continue reading >>
Best And Worst Foods For Diabetes
Your food choices matter a lot when you've got diabetes. Some are better than others. Nothing is completely off limits. Even items that you might think of as "the worst" could be occasional treats -- in tiny amounts. But they won't help you nutrition-wise, and it's easiest to manage your diabetes if you mainly stick to the "best" options. Starches Your body needs carbs. But you want to choose wisely. Use this list as a guide. Best Choices Whole grains, such as brown rice, oatmeal, quinoa, millet, or amaranth Baked sweet potato Items made with whole grains and no (or very little) added sugar Worst Choices Processed grains, such as white rice or white flour Cereals with little whole grains and lots of sugar White bread French fries Fried white-flour tortillas Vegetables Load up! You'll get fiber and very little fat or salt (unless you add them). Remember, potatoes and corn count as carbs. Best Choices Fresh veggies, eaten raw or lightly steamed, roasted, or grilled Plain frozen vegetables, lightly steamed Greens such as kale, spinach, and arugula. Iceberg lettuce is not as great, because it's low in nutrients. Low sodium or unsalted canned vegetables Go for a variety of colors: dark greens, red or orange (think of carrots or red peppers), whites (onions) and even purple (eggplants). The 2015 U.S. guidelines recommend 2.5 cups of veggies per day. Worst Choices Canned vegetables with lots of added sodium Veggies cooked with lots of added butter, cheese, or sauce Pickles, if you need to limit sodium -- otherwise, pickles are okay. Sauerkraut, for the same reason as pickles -- so, limit them if you have high blood pressure Fruits They give you carbohydrates, vitamins, minerals, and fiber. Most are naturally low in fat and sodium. But they tend to have more carbs Continue reading >>
Food And Diabetes
Dietary Advice for people with Type 2 Diabetes When you have Type 2 diabetes your nutritional needs are the same as everyone else—no special foods or complicated diets are needed. The key to eating well with diabetes is eating regularly, watching your serving size and following a healthy eating plan that is low in refined sugars and fat. This means choosing lower fat options when eating meat, poultry, dairy products and spreads, enjoying a good variety of fresh fruit and vegetables, getting the majority of your energy from unrefined and whole grain starches (e.g. potatoes and wholegrain bread and cereals) and keeping high sugar, high fat foods as treats only. You need more than 40 different nutrients for good health and no single food supplies them all. Eating a wide variety of foods is the key to ensuring that you get all the nutrients you need. Our "Healthy eating for people with type diabetes booklet" is an easy-to-read guide which has been prepared specifically for people with type 2 diabetes and for those waiting to see a dietitian, however the booklet provides useful guidance for everyone interested in developing healthy eating habits. Useful resources: Healthy eating for people with type 2 diabetes booklet Getting active for better health Continue reading >>
The 15 Best Superfoods For Diabetics
beats1/Shutterstock Chocolate is rich in flavonoids, and research shows that these nutrients reduce insulin resistance, improve insulin sensitivity, drop insulin levels and fasting blood glucose, and blunt cravings. But not all chocolate is created equal. In a 2008 study from the University of Copenhagen, people who ate dark chocolate reported that they felt less like eating sweet, salty, or fatty foods compared to volunteers given milk chocolate, with its lower levels of beneficial flavonoids (and, often, more sugar and fat, too). Dark chocolate also cut the amount of pizza that volunteers consumed later in the same day, by 15 percent. The flavonoids in chocolate have also been shown to lower stroke risk, calm blood pressure, and reduce your risk for a heart attack by 2 percent over five years. (Want more delicious, healthy, seasonal foods? Click here.) Jiri Vaclavek/Shutterstock Broccoli is an anti-diabetes superhero. As with other cruciferous veggies, like kale and cauliflower, it contains a compound called sulforaphane, which triggers several anti-inflammatory processes that improve blood sugar control and protect blood vessels from the cardiovascular damage that's often a consequence of diabetes. (Heart disease is the leading cause of death for people with diabetes, so this protection could be a lifesaver.) Sulforaphane also helps flip on the body's natural detox mechanisms, coaxing enzymes to turn dangerous cancer-causing chemicals into more innocent forms that the body can easily release. Blueberries funnyangel/Shutterstock Blueberries really stand out: They contain both insoluble fiber (which "flushes" fat out of your system) and soluble fiber (which slows down the emptying of your stomach, and improves blood sugar control). In a study by the USDA, peopl Continue reading >>


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Experts at Datalase
Billy GreenBusiness development manager, Europe & APAC Contact Expert
Billy has 25 years' experience in the global ink and printing industries; in addition to 11 years in the coding and marking industry, focusing specifically on the use of lasers/coatings for FMCG primary, secondary and tertiary packaging applications.
Chuck PembleVP business development, Americas Contact Expert
Highly experienced business development executive with 25 years' experience in manufacturing & production. Chuck has proven ability to drive new business & leverage supply-chain partnerships specialising in track & trace, identification & brand protection
Mark NaplesBusiness development manager, Europe & Asia Contact Expert
Mark has over 15 years experience in understanding the real-world requirements of end-users looking to improve efficiency across all areas of factory automation processes, with a particular emphasis on product differentiation and late-stage customisation.


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text: adresse edtube Mar 15 2017. Only the Chapel was spared by the strength of its arches. 7 The Royal Danish Army left the castle in 1923, and after a thorough renovation it was opened to the public in 1938. Afterwards, the defences were strengthened significantly. You can meet the famous characters when you go through the castle and witness their drama, intrigues and tragic fates. See also edit References edit Notes Kronborg Castle at the website of unesco's World Heritage Centre Donnelly 1984,. . Zealand at the narrowest point of the Øresund, the sound between present Denmark and the provinces of present Sweden that were also Danish at the time the castle was built. 9 The tapestries were commissioned by Frederick II around 1580.


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View listing information for 1628 Briar Hill Way, Maryville, TN, 37803. Listing details information provided by Ron Hill. $324,900 USD: All brick, Three bedroom, 2 1/2 bath, daylight basement rancher, spacious open kitchen, Large master suite with walk-in closets, master bath has Jacuzzi tub & walk in shower.
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The Six Mile Creek property is tucked away in a private setting just outside of Maryville, Tennessee and just minutes from the Great Smoky Mountains National Park, Chilhowee Lake, Tellico Lake, and The Dragon. This property is located in Blount County (Maryville), Tennessee
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Palestinian protesters flee from incoming teargas canisters during clashes with Israeli forces along the border with the Gaza strip east of Gaza City on May 4, 2018, on the sixth straight Friday of mass demonstrations calling for the right to return to their historic homelands. / AFP / MAHMUD HAMS
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Israeli troops fired live rounds and tear gas at Palestinians thronging the Gaza-Israel border Friday as part of a long-running protest, injuring about 350 people.Medics said around 50 people were shot and wounded with live fire, three of them critically, and 300 more treated for gas inhalation and other injuries along the Gaza side of the 40 kilometer border fence, where Palestinians set up tent encampments on March 30 for what they call "The Great March of Return". Army gunfire has killed 49 Palestinians on the frontier over the last month.Israel says that the protests have been organized by Hamas to provide


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Harrogate Autumn Flower Show joins the chilli-fiesta trend this autumn. Show organiser Martin Fish said the mini festival will link growing and cooking. It will also include a series of talks and demonstrations.
Young-plant suppliers say there is growing demand for unusual chillies. Quantil retail sales manager Mark Clementson said Apache and Scotch bonnet have become established staples over the past few years. "There is certainly good demand for more unusual varieties," he added.
Mr Fothergill's Seeds retail marketing manager Ian Cross said the hype does not match sales. "They do surprisingly poorly against the amount of interest they generate." He puts this down to people not needing to use a lot to cook with and the relative difficulty in growing them.
Cross described the market as niche and said although there has been an increase in the varieties available, this only leads to small incremental sales gains.
Charnwood Chilli Co owner Ady Dayman of BBC Radio Leicester and BBC1's East Midlands Today said: "They're cool because they're a bit different. We want to educate people about chillies. They aren't difficult to grow. People think they're annuals but if you bring them inside they've got six or seven years in them. There's misconceptions about them.
"We grow 140 varieties and make our sauces ourselves. We've got our own nursery (Derry's) where we grow perennials, shrubs, trees and bedding, then I started growing a few chillies too and sold them at farmers' markets wearing a sombrero and hand-drawn T-shirts. You've got to diversify in the nursery trade these days."
Chilli festivals - This summer's schedule
19-20 July - Fourth Birmingham Chilli Festival, Brindleyplace, Birmingham.
9-11 August - West Dean Chilli Fiesta, Chichester, West Sussex.
25-26 August - Benington Lordship Gardens Chilli Festival, Stevenage, Hertfordshire.
Frosts Garden Centres Chilli Festival 24-26 August Woburn Sands; 31 August-1 September Millets Farm.
6-7 September - Fifth Upton Cheyney Chilli Festival, Bristol.
13-15 September - Harrogate Autumn Show First Chillifest.
21-23 September - Great Scottish Brave Harvest Chilli Festival, Scone Palace, Perth, Scotland.
29 September - Dorothy Clive Chilli Festival, Market Drayton.


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A lot has changed in the Tees Valley in the last few years.
We've seen political boundaries redrawn, a shift in allegiance from Labour to Conservative, political change linked to the devolution agenda, the creation of the Tees Valley Combined Authority, and a new post of elected mayor.
This has created some green shoots of optimism about the area and a new momentum for change.
One of those green shoots has been the establishment of the RSA Tees Valley Fellows' Network – a local group of RSA members like us committed to creating social change. To make the biggest impact, our first project is about young people and democracy.
Empowering young people in the Tees Valley
Despite encouraging political changes in the Tees Valley, there remains a great deal of pessimism and cynicism. This is unsurprising – growing frustration with politics and an increasing sense of disempowerment are, ironically, unifying aspects of modern British life according to recent analysis by the Hansard Society.
In this area, many children grow up believing that they have little control over their own lives and environment.
As a whole, the school system fails to tackle these problems head on. It's easy for civic skills training and democratic education fall by the wayside in many schools. Disheartened societies tend to produce disillusioned young people – and these same young people go on to shape our future. We need to break the cycle.
Hence our choice of topic. When Matthew Taylor gave his 2018 Chief Executive's lecture on deliberative democracy, he asked for a formal pledge from Fellows to pursue the extension of democratic participation. Creating a more responsive and participatory democracy, he argued, will require a culture-shift – both in government and in wider society. And what better place to start spreading this culture than in schools.
How our sixth form democracy enlightenment programme will work
For one of our first project's the RSA Tees Valley Fellows' Network is bringing sixth formers from across the region together for a 'Democracy Day'.
There, helped by inspirational speakers and RSA Fellows acting as mentors, teams of students will compete to produce the best Manifesto for a 21st century democracy. We want to make sure each team has students from different schools. This will allow participants to learn from each other, whether they come from a state or independent school, or a different part of the region.
We want students to take new ideas back to their own school. They'll produce a 'school democracy action plan', reflecting on the democracy day and how to improve democracy in their own school. We think democracy in school matters, helping to teach young people that their voices should be heard.
Then each school will elect 2 representatives to our new Tees Valley 6th form Democracy Council. We want local politicians to take part at this stage, so students can see local democracy in action.
That council will pick one school to present their ideas at the RSA in London – connecting this project back up with the RSA's work on education.
We're excited that this local idea has been awarded an RSA Catalyst Grant and the first democracy day will take place at Barnard Castle School in the Tees Valley in October 2019.
Giving students confidence, rebuilding democracy, and having fun
We hope this work will inspire local young people. But whatever the outcome of this project, we want to send the message that young people are citizens who deserve to have their voices heard.
We want students to feel more confident in their ability to change the world and more equipped to think critically and maximise their positive impact in the world. We also hope that by spreading democratic skills and trialing a new model of civic education, we will lay the foundations for more transformative democratic experiments in the area.
It's easy to be cowed by the magnitude of the challenges we face. We need root and branch change and a genuine paradigm-shift. None of this will happen until we start to rebuild faith in our system of governance. And this won't happen unless people are given the tools and opportunities to participate meaningfully in political life.
We think working with young people is an exciting place to start. Not least because they are more open to ending cynicism and having some fun – we want people to enjoy democracy and debate.
We've already enjoyed working with young people and getting them excited about how they can change things. We look forward to continuing to grow as a network linking Fellows across the North!
Thanks to David Cresswell, Jon Elphick, Eric Sandelands, and Riley Thorhold for contributing to this blog. The RSA Tees Valley Fellows' Network is led by Eric Sandelands, Andy Price, and Paul Ingram.


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The Mammography X-ray Market Report highlights the current and future aspects of the market analysis based on changing industry trends and market scenarios.
The company's recently released report focuses primarily on required customer solutions. The study includes analysis, forecasting and sales from 2018 to 2026. The Mammography X-ray Machines Market report focuses on the development of this market in terms of value and volume during the forecast period. The data is highlighted in charts and tables to better understand changing market trends. The report consists of factors and challenges followed by a complete analysis of the key market players. The market is expected to reach USD XX million by 2026, with a CAGR of XX%.
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* Provides a detailed description of key players and their marketing strategies, followed by press releases and relevant documents to understand competitive analysis.
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Some of the key players in the Mammography X-ray Machine market are:
GE Healthcare
Philips Healthcare
Toshiba Medical
IMS Giotto
Carestream Health
Wandong Medical
Perlong Medical
Physical examination
* North America (USA, Canada, Mexico)
* Europe (UK, France, Germany, Spain, Italy and the rest of Europe)
* Asia Pacific (China, Japan, South Korea, ASEAN, India, Rest of Asia Pacific)
* Latin America (Brazil, Argentina, Colombia, and the rest of L.A.)
* Middle East and Africa (Turkey, GCC, UAE and South Africa Middle East)
This report answers the following key questions:
* Which companies are profiled in the report?
* How are regions segmented? Is there country-specific segmentation?
* How are regions segmented? Is there country-specific segmentation?
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* What factors affect the market share of different regions?
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Chapters included in the report:
Chapter 1: Market Overview, Influencing Factors, Limitations & Opportunities, Segmentation Overview
Chapter 2: Manufacturers Market Competition
Chapter 3: Production by Region
Chapter 4: Consumption by Region
Chapter 5: Production, by Type, Turnover and Market Share by Type
Chapter 6: Consumption by Application, Market Share (%) and Growth Rate by Application
Chapter 7: Complete Manufacturers Profiling and Analysis
Chapter 8: Manufacturing Cost Analysis, Raw Materials Analysis, Regional Production Cost
Chapter 9: Industry Chain, Supply Strategy, and Lower Customers
Chapter 10: Marketing Strategy Analysis, Distributors / Distributors
Chapter 11: Market Effect Factors Analysis
Chapter 12: Market Forecast
Chapter 13: Mammography X-ray Equipment Research Findings and Conclusion, Appendix, methodology and bibliography