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Conventionally, immunotoxins have been produced as a single polypeptide from fused genes of an antibody fragment and a toxin. In this study, we adopted a unique approach of chemical conjugation of a toxin protein and an antibody fragment. The two genes were separately expressed in
Most anticancer monoclonal antibodies exhibit weak antibody-dependent cytotoxic activity. A recombinant immunotoxin is a genetically engineered antibody fragment conjoined to a protein toxin that reduces the tumor tissues (1). The antibody region of these molecules specifically targets tumor cell surface receptors and then internalizes toward the endocytic compartment. Toxin molecules delivered to the cytosol of the target tumor cells destroy the target cells effectively (2, 3).
Human breast cancers are classified into subtypes depending on their gene expression patterns (4). The overexpression of human epidermal growth factor receptor 2 (HER2), also called HER2/neu, ERBB2, or CD340, has been observed in 20–30% of all breast tumors (5). HER2, a 185-kDa transmembrane tyrosine kinase receptor, belongs to the epidermal growth receptor (EGFR) family 2. The phosphorylation of HER2 dimers results in the activation of various downstream processes, such as cell proliferation, survival, differentiation, angiogenesis, invasion, and metastasis (6). Patients with HER2 overexpression show a significantly poor prognosis and overexpression of HER2 in breast tissues stimulates malignant phenotypic transformation. In addition, HER2-overexpressing tumors are more resistant to general chemotherapy treatment (7).
Trastuzumab, an anti-HER2 antibody, has been approved by the FDA for the treatment of HER2-positive early-stage breast cancer and metastatic breast cancer (8). Trastuzumab blocks HER2 signaling by binding to its extracellular domain and attracts immune cells to tumor sites, resulting in the inhibition of tumor growth (9). Because trastuzumab itself showed weak antibody-dependent cell cytotoxicity, it has been conjugated with various chemical drugs to enhance cytotoxicity for active targeting against HER2-positive breast cancer cells (10).
In this study, we adopted a unique approach of chemical conjugation between an antibody fragment and a toxin instead of the traditional immunotoxins that are recombinant fusion proteins of the two proteins. An advantage of this approach is that it can overcome the problem of low recombinant immunotoxin production that is observed in some immunotoxins. As a proof of concept, the scFv of trastuzumab and the PE24 protein were produced separately using
To fuse three PCR products (i.e., VH, VL, and donor vector [pDONR207]) and create pENTR–HER2(scFv), an overlap cloning method was used. The primers were designed for PCR products to have homologous sequences at both the ends. After overlap cloning, the TEV cleavage site was added at the N-terminal of HER2(scFv), and cysteine residue was added at the C-terminal for crosslinking reaction. A linker was inserted between VH and VL. The attL1 or attL2 site was added at each terminal for the next cloning step, and the expression vector for MBP–HER2(scFv) was obtained using the LR reaction of the gateway cloning method with pENTR–HER2(scFv) and pDEST–HMGWA containing MBP tag (Fig. 1A, C). For making the PE24 expression vector, a multisite gateway cloning method was used. PE24-encoding gene was amplified by PCR. The attB1 and TEVrs sequence at the N-terminal and attB5 at the C-terminal of PE24 were added. attB site-flanked PE24 was inserted to the donor vector (pDONR221) by BP reaction and pENTR–PE24 was formed. The expression vector for His8–PE24 was created by LR reaction with His8 tag containing pDEST–His8 and pENTR–PE24 (Fig. 1B, D).
The expression vector for MBP–HER2(scFv) or His8–PE24 was transformed to
PE24 also was purified by IMAC chromatography, however, the His8–PE24 fusion protein was eluted at 500 mM imidazole. TEV protease was treated to the eluted His8–PE24 at a ratio of 20:1 with 1 mM DTT addition. After the TEV protease digestion, PE24 was purified from the FT fraction of the 2nd IMAC column in the same manner as HER2(scFv) (
To generate an anti-HER2 immunoconjugate, anti-HER2(scFv) and PE24 were chemically conjugated via N-succinimidyl-3-(2-pyridyldithio)propionate (SPDP), a disulfide bond-containing linker. The amino groups of PE24 were modified with SPDP (Fig. 2B, lane 1), and HER2(scFv)-Cys was reduced by TECP to make the sulfhydryl group available for conjugation (Fig. 2B, lane 2). After a reaction at a ratio of 5:1 (PE24:HER2(scFv)), the HER2(scFv)–PE24 conjugate was formed (Fig. 2B, lane 3). Then, this conjugate was purified by size exclusion chromatography using the Hiload 16/600 Superdex 75 pg (Fig. 2B, lane 4). The purity of the purified HER2(scFv)–PE24 conjugate was verified by SDS-PAGE under non-reducing condition (10% Tricine gel). The highest yield and purity of the HER2(scFv)–PE24 conjugate was 58% and 93%, respectively (
To evaluate the binding capacity of the HER2(scFv)–PE24 conjugate, the HER2(scFv)–GFP conjugate was prepared and flow cytometry analysis was performed. After incubation with HER2(scFv)–GFP, a shift of the fluorescence histogram to the right was observed in the HER2-overexpressing cell lines, SKBR3 and BT-474 (Fig. 3A, B). On the contrary, the fluorescence histogram shifted slightly in HER2 low-expressing cells (MDA-MB-231, MCF-7) as compared with that in HER2-overexpressing cells (Fig. 3C, D). From the fluorescence-activated cell sorting (FACS) analysis data, we determined that the HER2(scFv)–PE24 conjugate strongly binds to HER2-expressing cells.
To determine the cytotoxicity of the HER2(scFv)–PE24 conjugate, HER2-overexpressing and low-expressing cells were treated with HER2(scFv)–PE24, HER2(scFv), and PE24 at various concentrations. At 72 h of treatment, an MTT assay was performed to measure the cell viability. The HER2(scFv)–PE24 conjugate revealed high toxicity in HER2-overexpressing cell lines (SKBR-3 and BT-474) at the picomolar level. The IC50 value of SKBR-3 and BT-474 is 43 pM ± 8 (n = 9) and 6.7 pM ± 3 pM (n = 9), respectively (Fig. 4A, B). In contrast, the HER2 low-expressing cell lines (MDA-MB-231 and MCF-7) were 20- to 1.4 × 103-fold less affected by the HER2(scFv)–PE24 conjugate. The obtained IC50 values of MDA-MB-231 and MCF-7 were 9.44 nM ± 3 nM (n = 9) and 1.01 nM ± 0.38 nM (n = 9), respectively (Fig. 4C, D). These data indicate that the cytotoxicity in cells is correlated with the HER2 expression on the cell surface. Treatment with HER2(scFv) alone did not inhibit the proliferation. Meanwhile, PE24 alone reduced cell viability at high concentration, except for the SKBR-3 cell line.
In this study, an antibody fragment and a toxin were produced separately from
Inside the cancer cell, the traditional recombinant immunotoxin is digested by the intracellular protease, furin, giving rise to dissociated antibody fragment and the toxin that interferes with intracellular function (16). The chemical crosslinker in our experiment creates a disulfide-containing linkage between the HER2(scFv) and PE24. Similar to furin cleavage site, the link would be cleaved inside the cell because of the reducing intracellular environment.
Four types of breast cancer cell lines were used to test the cytotoxicity of the chemically conjugated HER2(scFv)–PE24. SKBR-3 and BT-474 expressed HER2 higher than MDA-MB231 and MCF-7 did, as per the FACS analysis using HER2(scFv)–GFP (Fig. 3). As expected, the cytotoxicity of the chemically conjugated immunotoxin was higher in SKBR-3 and BT-474 with IC50 of the picomolar range, whereas the other two cell lines showed IC50 of the nanomolar range (Fig. 4). This cytotoxicity of the chemically conjugated HER2(scFv)–PE24 on the four breast cancer cells was comparable to that of the conventional HER2(scFv)–PE24 (unpublished result), demonstrating the feasibility of the chemically conjugated immunotoxin. The efficacy of immunotoxins can be augmented by a hundred- or thousand-fold, but more than a million fold by endosomal escape enhancers in exceptional cases, such as lysosomotropic amines, carboxylic ionophores, calcium channel antagonists, various cell-penetrating peptides, other organic molecules, and light-induced techniques (17). Our immunotoxin already demonstrated IC50 of picomolar range, and it remains to be decided how much these endosomal escape enhancers could increase the efficacy.
In patients with solid tumors that have normal immune systems, PE is highly immunogenic because it is a bacterial protein. Anti-drug antibodies (ADA) were detected in all mesothelioma patients who were treated with recombinant immunotoxins (RIT) that contained PE (18). The ADA neutralized the RIT and prevented further treatment. Because immunocompromised hematological patients do not show a strong ADA response, a combination therapy of a RIT with an aggressive immunosuppression regimen was evaluated in patients with advanced chemo-resistant mesothelioma. ADA formation was delayed so that more cycles could be provided, and 40% of the patients showed dramatic tumor responses that substantially increased survival (19). This result demonstrated that RITs could induce major regressions in mesothelioma once immunogenicity was resolved and highlights the need to control immunogenicity to make therapy more effective.
PE38 was at the common fragment form of PE for recombinant immunotoxin (20). However, the nonspecific toxicity and strong immunogenicity of PE38 were the limitations of PE-based immunotoxins (21). For the prevention of immunogenicity, most of the domain II (253–364 a.a.) as B-cell and T-cell epitopes, except for the furin cleavage site, was removed. This fragment, PE24, significantly decreased immunogenicity and the nonspecific toxicity of PE (22). In addition, six amino acids of PE were identified as the B-cell epitope (23, 24). Six other amino acids of PE were mutated to decrease the immunogenicity of T-cell response (22, 25). Two amino acid positions were overlapped so that 10 amino acids were mutated for dual B- and T-cell de-immunization (26). Our PE24 was derived from 8 amino acid mutations to remove the B-cell epitope (27). Obviously, our PE toxin requires improvements in de-immunization.
Despite immunotoxins showing encouraging effects in clinical or preclinical animal trials, its short
In conclusion, the present study represents another method of generating an immunotoxin. HER2(scFv) and PE24 were produced separately with high purities from
To create the expression vector for MBP–HER2(scFv), overlap cloning and multisite gateway cloning were performed. For the expression vector of His8–PE24, multisite gateway cloning method was used. More detail about these constructs is shown in the
Expression plasmids were transformed into
HER2(scFv) and PE24 proteins were expressed in
Crosslinking between HER2(scFv) and PE24 was performed using sulfo-LC-SPDP, as described in the
HER2(scFv)–GFP was produced, as described in the
The cells were trypsinized and 2 × 106 cells were centrifuged and resuspended in 1 mL PBS. Then, 5 μg of HER2(scFv)–GFP conjugate was added to each tube and incubated at 4°C for 25 min. The cells were washed with PBS three times, and 1 μg DAPI was added to each tube and incubated at 4°C for 10 min. After washing three times, the cells were analyzed by FACS Canto II flow cytometer (BD Biosciences, San Diego, CA). FlowJo_V10 (FlowJo LLC, Ashland, OR) was used to analyze FACS data.
The SKBR-3, BT-474, MDA-MB231, and MCF-7 cells were grown in RPMI 1640 medium supplemented with 10% fetal bovine serum. The cells were seeded into 24-well plate at a density of 0.5-1 × 105 cells per well. After culturing for 24 h, HER2(scFv)–PE24 conjugate was treated to seeded cell at different concentrations (0.002, 0.02, 0.2, 2, 20, and 200 nM). At 72 h of incubation with the conjugate, MTT assay was performed as described in the
Data are presented as mean ± standard error of n ≥ 3 samples. The experiments were performed independently in triplicate.
This study was supported by grants from the National Research Foundation of Korea (NRF-2015K1A4A3046807 and 2017M3A9F8031039) and a grant from the Asan Institute for Life Sciences, Seoul, Korea (2019-307).
The authors have no conflicting interests.


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Update (3:40 P.M.): Jim Parsons has responded to Big Bang Theory's impending end on Instagram, posting a cast photo along with a note. "It is hard (nearly impossible, actually) to really accept that this is a picture of the first of the final 24 episodes we will shoot for The Big Bang Theory," the actor wrote. "I feel very fortunate that we have another 23 episodes to shoot this season because I am hopeful that with each and every one, my level of REALLY accepting this fact will sink in."
Parsons expressed extreme gratitude for the show's crew—many of whom, he noted, have been with the show from the beginning—as well as the writers, "because without them, there would literally be no Big Bang Theory at all, ever."
"And while I know that they already know it, it bears repeating again and again: I am so terribly grateful for the cast in this picture and the cast members who aren't pictured here; whether they are in one scene or many episodes along the way; you are all my playmates that I have fallen in love with and who have become a part of my life on set and off," Parsons continued. "You are my playmates when we don't feel like playing but have to because it's our job to get out there and communicate and pretend we're these other fictional people and we look into each other's eyes and say these words and end up creating this weird, other reality that has enriched my life more than I will fully ever understand. I will miss all of you and all of this more than I can say and more than I can know at this time."
The original post continues below.
With The Big Bang Theory coming to a close next year, its cast is about to experience a big bang of their own. (Sorry.) The show's original actors have called this series home for more than a decade, and saying goodbye will almost certainly be a major adjustment. But one cast member was reportedly very ready to leave—so ready, in fact, that he turned down more than $50 million to stay for two more seasons, catalyzing the show's cancellation. After all, what would Big Bang be without its biggest breakout star, Jim Parsons?
According to Entertainment Weekly, CBS tried to secure the sitcom's original cast members—Parsons, Kaley Cuoco, Johnny Galecki, Kunal Nayyar, and Simon Helberg—for two more years, with a deal that would have nabbed each actor $50 million including profits. CBS Entertainment President Kelly Kahl told reporters earlier this month that the network was trying to renew the show, saying, "We don't believe it's the final year." Parsons, however, was apparently ready to move on—an understandable desire for anyone who's played the same character for 12 years. A representative for Parsons did not immediately respond to V.F.'s request for comment.
One person who seems very sad to be leaving the show? Cuoco reacted to the news on Instagram Wednesday night, writing that she was "drowning in tears."
"This ride has been a dream come true and as life changing as it gets," Cuoco wrote. "No matter when it was going to end, my heart would have always been broken in two. Drowning in tears, we promise to bring you the best season yet. To the fans, our crew, families, Chuck Lorre, Warner Brothers , CBS, and everyone who has supported us for so many years, thank you. We are goin out with a bang."

subset: commoncrawl


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Anne Mulvihill + Nancy Latarte, Fête in France
Did you know that most destination weddings in France are symbolic ceremonies? Neither did I.
Photos courtesy of Fête in France
Sooo many dream of having a destination wedding in Paris, France and THESE ladies have planned HUNDREDS of events in France and have made QUITE a name for themselves in the industry.
Anne Mulvihill and Nancy Latart of the uber-popular Paris boutique event and wedding planning agency, Fête in France want to help you understand everything there is to know about getting married in Paris - make that all of France. So much so that they sat with me for about an hour and let me ask as maaany questions as I could. Clocking hundreds of events, this dynamic duo gives us a peek "behind the veil" of destination wedding planning in France and shares the wealth on everything from avoiding residency requirements and the best/worst wedding months, to choosing vendors and their favorite venues and so much more!
Now, Anne and Nancy may have the most comprehensive Show Notes thus far because they shared so many venues, photos and french traditions - and it's all below just for you!
Anne and Nancy of Fête in France run the most experienced wedding planning agency in Paris and specialize in luxury events all over France for an international clientele.
They have been featured in numerous publications including Martha Stewart Weddings and they have entered DestiLand and agreed to be our DestiPros + Bridefriends for the day and share their BEST tips for destination wedding planning and share some great stories.
How to plan a destination wedding in France including the ever-so-popular Paris
Is it important to visit your destination before your wedding date?
What to do if you cannot visit your destination?
The best and worst months to have a wedding in Paris, France
How to get around the residency requirement and have your destination wedding in France
What makes a great destination wedding planner?
Religious ceremony options
Destination wedding planner vs. destination wedding coordinator
Money saving tips
Reasons to love France
Ways to infuse French traditions into your destination wedding
Most destination weddings in France are symbolic ceremonies!
The Red Dress
Photos courtesy of Greg Finck
on Symbolic vs. Civil Ceremonies for destination weddings…
A Croquembouche (or Croque-en-bouche) is a French dessert traditionally served at weddings, baptisms, and first communions. They are pastry balls piled into a cone and bound with threads of caramel and occasionally decorated with sparklers. What a treat for your guests!
Thanks for Listening!
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Wild weather chaos hits NSW
Jocelyne Basseal was making breakfast for her two young children when she noticed floodwaters creeping towards her front doorstep in Sydney's inner west.
It was overflow from the flooded Cooks River, which was swelling over Riverside Crescent and into her home.
Before long, she was handing her children, four-year-old Amelia and Jonah, 2, to two men in yellow uniforms who had climbed over a side gate and waded through metre-high waters in teeming rain.
"I had no idea at this stage how high the flood would reach," Ms Basseal told AAP.
"It was traumatic for the kids."
The youngsters were among 15 people evacuated from Marrickville, in an area where 20 cars were under water.
A block away, eight cars and two motorbikes in an underground unit car park were wrecked as raw sewage leaked from a downpipe.
It was also garbage collection day, which meant smelly debris was scattered everywhere, along with grass clippings from the nearby golf course.
Across Sydney, 134 millimetres of rain drenched the city over 24 hours in what the Bureau of Meteorology said was the heaviest rainfall in five years.
There was more chaos on the roads, with Fire and Rescue NSW responding to 18 road accidents in the seven hours to midday.
On the train network, flooding caused signalling problems at Town Hall, suspending services between Central and Martin Place.
There were delays on nine of Sydney's 16 main railway lines, while flights from Sydney Airport were delayed or cancelled, with a Qantas plane bound for Sydney forced to divert to Newcastle.
Two northbound lanes on the main deck of the Sydney Harbour Bridge were closed for emergency repairs.
NSW Transport Minister Duncan Gay described the bucketing as a "one-in-a-hundred-year event".
"We've had a hell of a rain event," he said.
In Sydney's southwest, about 20 people were evacuated from a retirement village at Austral.
Near the Georges River, in the city's south, residents at 90 homes in Milperra and Picnic Point were warned about flooding.
Residents by the beach weren't spared, with a waterspout at Maroubra causing the wall of a pizza shop to collapse.
On Sydney Harbour, hundreds of boats, including a nine-metre cruiser, were in danger of sinking, while a short distance away, the downpours caused a landslip behind a home at Middle Cove.
The weather also caused grief south of Sydney, with torrential rain in the Illawarra and Southern Highlands and five-metre waves rolling into beaches around Bega and Nowra on the state's south coast.
The SES rescued 120 students and teachers from a Mittagong school who became trapped in the Belanglo State Forest when floodwaters cut a causeway.
The deluge also forced the postponement of funeral services at the Forest Lawn Memorial Park at Leppington in Sydney's southwest.
Spokesman Karl Wolfperson said access was cut by flooding of Camden Valley Way.
Meanwhile, a police officer was lucky to escape serious injury after plunging 30 metres down the side of a mountain in Nowra about 12.30am (AEDT) on Thursday while helping the SES deal with a fallen tree.
There were more than 700 calls for assistance and 19 rescues since the wild weather hit on Wednesday night, an SES spokesman said.


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'Necessary truths' are (or are internally related to) rules of representation and reasoning, which form the network of concepts and transitions between concepts and propositions in terms of which we describe how things are. Although we present them to ourselves as truths, and although we conceive of them as necessarily true and think of them as describing objectively necessary facts, they are not descriptions at all, but expressions of rules for forming descriptions. They are forms of representation.
G.P Baker and P.M.S Hacker, 'Grammar and Necessity', in Wittgenstein: Rules, Grammar and Necessity, p. 320
Here we have a nice encapsulation of Wittgenstein's important insight into the nature of necessity, an insight that goes to the heart of what philosophy is. Already in the Tractatus, Wittgenstein was claiming the only kind of necessity that existed is logical necessity:
A necessity for one thing to happen because another has happened does not exist. There is only logical necessity.
That is, whenever we describe something as necessary, though we may not be aware of it, we are describing a logical connection. For example, say we contend that a fruit cake necessarily contains raisins, that without raisins, it cannot count as a fruitcake. This is asserting a logical or conceptual relationship, not an empirical one. We are defining what a fruitcake is. Necessity and logic go hand in hand in this way. What about if we say that in order to get to the job interview on time, you must (necessarily) catch the 9.20 from Paddington station? Is this a conceptual/logical or an empirical connection? Are there really no circumstances at all under which you could miss this train but still make your appointment? Might you not, for example, call them up and let them know you will be late? Might there not after all be a bus that gets you there on time? Whenever the 'must' is not iron-clad, it is an empirical, not a logical, proposition.
Saying necessary connections are logical is, on Wittgenstein's view, a tautology, for these two terms mean the same. The necessary/contingent distinction is exactly the same as the logical/empirical distinction. He does not eradicate the distinction, as Quine tried to do. Contingent truths are true, but might have been false. Necessary truths could not have been otherwise. Their falsity makes no sense. This means it is excluded from empirical discourse. It has no use.
But there are nuances among necessary/logical truths. There are necessary propositions/necessary truths which belong to the domain of logic, such as the law of the excluded middle (P v ~P), the law of non-contradiction (~(P & ~P)), and other laws (e.g. if all F's are G, and x is F, then x is G). Their common element is that they are all tautologies. It is the recognition of these as tautologies that consigns them to the domain of logic. They are not descriptions of any state of affairs; they say nothing about the world–they are unconditionally true. They are not meaningless however: they are tautologies. They can be employed in reasoning and the establishment of proofs or contradictions. That is their purpose. That is their use, which is, for Wittgenstein, the chief determinant of meaning.
Arithmetical propositions are similar in that they are not descriptions of the world, nor indeed of a mathematical reality, and say nothing. They are not useless however. They license the transformation of empirical propositions. For example, because it is (necessarily) true that 2 + 2 =4, we are entitled to go from 'I had two apples and I bought two more' to 'I have four apples'. Empirical claims such as this are, of course, contingent; I might have eaten one of the apples. Indeed in any applied example that involves counting or arithmetic, the arrival at the correct answer (e.g. 4 apples) is never inevitable. It is not 'in the nature of things', as Frege thought, that if we start with two things then add two more things we will inevitably have four things. There is no such inevitability unless we explicitly say so by our knowledge that nothing else was added, or we apply a ceteris paribus clause. Arithmetical claims are different; they are necessary. This is not because arithmetic is in the nature of things, but because we reserve arithmetic from falsification. Nothing could show 2 + 2 is not 4. This is a social practice, but that does not mean arithmetic is true by convention, or true because we say it is. We do not make arithmetic true. Nothing makes it true. It is unconditionally true. As before, their meaning is closely related to their use–which is only in connection to empirical propositions. If they have no use in this regard, they are like the rules of a theoretical game nobody ever plays.
Then there are what Wittgenstein called 'grammatical' propositions which specify other rules for the use of words. For example, 'red is a colour' is a grammatical proposition that specifies a rule for the use of the words 'red' and 'colour'. These cause trouble in philosophy because they can look similar to empirical claims; in fact, out of context, they can look indistinguishable from empirical claims. For example, 'This (pointing to an object) is red'. In one case, this might be an ostensive definition of red: teaching the meaning of 'red' to someone by pointing at a sample object. On another occasion, it might be an empirical claim: 'This car is red. It was supposed to be green.' One is definitional, conceptual, unconditional, i.e. necessary. To deny it is to say nothing about the world; it is only to dispute the validity of employing a sign for a certain concept. The latter usage is factual, empirical, falsifiable, i.e. contingent.
Logic, mathematics, grammar: these are rules for the use of language and constitute forms of representation. We sometimes call them true, and this is one way in which philosophers sometimes get into trouble and fail to clearly understand their difference from empirical propositions. Empirical propositions are true or false. Logic, mathematics and grammar are not the same. For them to be 'true' is just to be a rule, to be accepted as something one has to be in accord with in order to make sense, to be understood. To be false is to be nothing, not even a rule. In chess, there is are rules for the movement of each piece. Moves that do not accord with these are simply not part of chess. So although we might say 2 + 2 = 4 is true, and 2 + 2 = 5 is false, these should not be understood as descriptions of any kind of reality, but just as statements of rules that ought to be followed, like '(it is true that) the bishop moves diagonally'.
Outside of these three kinds of rules or necessary truths, there are some propositions which are somewhere between the empirical and the necessary, and these are dealt with in Wittgenstein's late paper, On Certainty. 'The world is billions of years old', 'water is H2O'. These are examples of proposed rules which have come to be accepted as rules. 'Water is H2O' is a rule that partially determine the meanings of the constituent terms. Such examples are cases of empirical propositions that have hardened into rules. Our forms of representation can in this sense change over time. Rules can be thrown out, and new ones adopted.
Philosophers have certainly spent ages pondering the metaphysics of the domain of logic and mathematics. Do numbers exist? Are there objects corresponding to the logical constants? The metaphysics of grammatical truths have also been rife in philosophy. Does 'redness' exist? Is the fact that red is a colour a 'law' of some special kind? Wittgenstein's correlation of necessary, logical and conceptual truths sweeps away metaphysics as a mythology resulting from treating some necessary truths as a special kind of super-hard contingent truth. In a quite ordinary or common sense, red things exist, and the concept of red exists, but apart from this, asking whether 'red' or 'redness' exists is meaningless. It is like asking whether Mozart's music smells. You can say 'no', but it is clearer to say there is no meaning to the question; that nothing counts as music with an odour.
On this account, the medieval debate in Tibetan philosophy concerning the ontological status of universals–which corresponds closely to the medieval Western debate on nominalism and conceptualism–is confused. The only kind of necessity is logical or conceptual necessity. The only point of logical and conceptual truths is their use in providing rules for the use of empirical propositions. They are not descriptions of anything. This is a sweeping away of metaphysics.
Everything empirical is contingent. It is is logical feature of the empirical domain that everything might have been otherwise. This insight itself is logical; it is a rule to clarify the proper employment of 'empirical' and 'contingent'. The casualty of this conclusion is metaphysics: nothing counts as a description of a non-empirical or ultimate reality. This is the insight that has important ramifications for traditional madhyamaka philosophy. Our understanding of emptiness, buddha nature, the kayas and wisdom, and all the ontology of Buddhist philosophy, will be misunderstood if thought of as metaphysical in nature, as a super-reality.


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Buy Rent
House Is Available For Sale
D.H.A, KarachiPKR 35,000,000
- Purpose: Buy
- Bedrooms: 4
- Marketed By: Raya Khan
- Area: 900 ft2
- Added: More than 6 months ago
House For Sale. Location: Dha Phase 8 Khaybane-E-Faisal. Good location. Best offer. D/D Room. With Lift. Study room. American Kitchen. East open. Best for living purpose. For more information please contact
General Amenities
- 4 Bedrooms:


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Spine Society of Australia
Combined meeting of the Canadian, New Zealand and Australian Spine Societies Lake Louise Canada February 26 - March 1, 2014
As you should be aware there will be a combined meeting of the SSA and the spine societies of Canada and New Zealand at Lake Louise in Canada between 24th Feb and 1st Mar 2014.
This meeting will not replace the regular meeting that will be held now in Brisbane in April 2014.
For further details of the combined meeting in Canada please consult the website page for this meeting or click here
For planning purposes I would be grateful if you could indicate your interest in this meeting by clicking here
You are receiving this notification because you have been automatically subscribed to the mailing list for information about this meeting. If you do not wish to receive further communication about this topic you may use the unsubscribe link below.
Best wishes
Peter Wilde


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About this Event
This will be an evening of laughter and entertainment by comedian Kerri Pomarolli, coffee, desserts and opportunities to participate in a raffle featuring designer purses!
General Admission: $20
VIP (includes premier seating, swag gift & photo opp): $30
Raffle tickets will be available at the show and the drawing will take place that night. Must be present to win. Cash, checks and cards will be accepted and raffle tickets will be $5 each or 5 for $20.
- VIP Photo Opp. (must have VIP ticket to enter): 6:30 p.m. - 7 p.m.
- Show Begins: 7:30 p.m.
Casual Attire
All proceeds support SafeHomes' mission to transform victims of domestic violence into survivors. Learn more about SafeHomes at www.safehomesdv.org or contact Jennifer at 706.564.8147.
Learn more about Kerri: http://www.kerripom.com/


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The Naked Truth
The news is devastating to the 13-year old boy inside us all: Playboy magazine will no longer print nude pictures. The magazine that coined the word "centerfold," will no longer have a use for the word it originated.
Playboy without nudes? That's like getting money from a bank without having to talk to a teller, filling your own gas tank at the service station or listening to radio that isn't being transmitted through a frequency to your bedside alarm clock.
It is progress, evolution, and necessary for survival.
I recently finished the audio book "Team of Teams" by General Stanley McChrystal. McChrystal rose through the ranks of an Army most of us recognize: order, discipline, structure, pictures of pin-up girls, top-down commands, and a clearly defined org chart. This is the Army depicted in movies, which won wars, and saved thousands of lives. This is the Army where if a commanding officer orders you to "jump" you ask "how high?"
As General of the Joint Special Operations Command in the mid-2000s, McChrystal quickly realized war was no longer like chess where one man was commanding all the troop movements of his enemy. Times had changed. Taliban and Isis were playing by different rules. The terrorists were recruited, trained, given the game plan and then empowered to make decisions in the moment. There was no way to keep up. As soon as JSOC thought they had a target in their sights, they had to wait to get the "go ahead" from McChrystal. Sometimes that meant waking him up and debriefing him, before he could make a decision. Each time, the targets vanished.
So they changed. McChrystal held a JSOC strategic meeting each day for everyone on the team. A video conference beamed to wherever his forces were stationed. Gone were the days where the General had a master plan and the forces were on a "need to know" basis. Now everyone knew everything. That created a shared consciousness. In addition, each unit was now empowered to execute in the moment based on collective intelligence, situational circumstances and timeliness. They became a team of teams.
It worked. The JSOC became more effective and agile. It morphed from a traditional org chart to an organizational web. McChrystal was hands off and eyes on. He was leading, not commanding. "Thank you" replaced the cold, directive language he was taught in the Army.
Thinking different.
Embracing change.
Adapting to technology.
Creating a collective intelligence and a shared consciousness.
Respecting and empowering your staff.
This isn't Google or Apple or a quirky start-up in Silicon Valley, this is the Joint Special Operations Command.
And now it is apparently Playboy Magazine.
For radio it is time. Our enemy is no longer the station down the dial. It's all around us and three steps ahead. We are battling for people's time and attention on the device of their choosing, for on and off air talent, for digital solutions and distribution platforms, and for monetization. Frankly, a fifth front could be a public perception problem.
This is no longer a problem solved by a billboard campaign or a clever TV spot. To win we need to do what we do differently. "Team of Teams" may be a good place to start.
If Radio Was Like Blueberries…
I spent a good half-hour talking to a blueberry farmer the other day. He was passionate, knowledgeable, and eager to discuss the business. He talk about how blueberries are becoming more popular internationally in China and some countries in Africa in addition to North & South America and Australia. He knew all about his competitors both regionally and internationally. He was gracious towards them. He saw them as a teammate in the global distribution, promotion and consumption of blueberries — instead of an evil enemy.
Ever notice we don't seek out varietals of blueberries? We go to the store and buy blueberries. In fact, there are several dozen popular kinds of blueberries. (I dare you to name two.) But the blueberry industry, the farmers and marketers, focus on getting blueberries in shopping carts and mouths. They aren't pushing you to eat Bluegold, Chandler, Elliott or Legacy blueberries. Just Blueberries.
What if radio did that?
What if everyone who grew and sold radio was passionate, knowledgeable, and eager to discuss the business?
What if we talked about the growing appetite of radio around the world and the role is plays in people's lives?
What if we really were knowledgeable about our radio competition home and abroad? And didn't talk bad about them?
What if we just all came together and encouraged everyone to listen to radio?
What if…?
Happy Birthday, Friend!?
Every year on 9/1 I get a few automated emails from companies I've done business with over the years. It's jarring at first until I realize the date. You see my birthday is actually 1/9.
My next thought is how they must've tasked data entry with a part-timer, an intern or someone who was too busy to be careful. Shame. A small gesture to build a relationship with the customer has actually done quite the opposite. One slip-up of a 1 and a 9 is an eternal reminder that you're just pretending to care about me, my birthday, our "relationship." And each year as I shake my head a little stronger I am reminder how very fragile consumer or listener relations really are.
The lesson here is be mindful of your listener's information. Treat it like diamonds. It is extremely valuable and you likely only get one shot to mine for it. And unlike real gems, if you're not careful with this it can turn to coal in an instant.
When Copyrights Trump Commercial Creativity (Spoiler: Always)
I was listening to radio this morning and heard a spot for a local restaurant trying to be relatable by exemplifying how hard it is for working adults to find time to eat breakfast. They preached the importance of the first meal of the day. And wouldn't you know it? They have a quick, easy, affordable breakfast sandwich you can pick-up on your way to the office to help solve your problem. Not a bad spot overall, but at one point the announcer says, "before you know it Heigh-Ho, Heigh-Ho it's off to work you go!" and then fairly quietly layered underneath was the unmistakable original recording of the seven dwarfs singing the song.
That's a problem.
- It's not an original work created by the advertiser.
- It doesn't qualify under "fair use" exceptions.
- The song isn't in public domain. The only songs that are public domain in the USA are songs and musical recordings published in 1922 or earlier. This song was released in 1937. (Check out the website here with examples of public domain works http://www.pdinfo.com/)
So, that means either Disney licensed copyright permissions to a local breakfast joint in central coast California or the restaurant and radio station stole it. It probably wasn't intentionally and in fact, it was a solid creative choice, but the law doesn't factor in intent, creativity or ignorance.
What should they have done? Here's some advice from business law firm Brooks/Pierce:
"To secure a license for a musical work, you will need to contact the publisher directly. You can obtain publisher contact information using the repertory databases maintained by ASACP (www.ascap.com), BMI (www.bmi.com), SESAC (www.sesac.com), and/or the Music Publishers' Association (www.mpa.org). If a sound recording license is also needed (e.g., for dubbing an original recording), you will also need to contact the record company directly. Record company contact information can sometimes be obtained by the music publisher and is often also available on the copy of the recording (e.g., the CD liner notes). Publisher and record company contact information may also be located on the U.S. Copyright Office's website (www.copyright.gov)."
That's a lot of time, work and likely money for a :07 sample of a song in a :30 radio ad that you're charging 50-bucks a spin for on your radio station.
Here's the kicker. Even if the radio station didn't produce the spot they can be held liable for copyright infringement. (Production Directors and Traffic Directors listen up!) Penalties can range from $150,000 to $250,000 per infringement and up to 10 years in prison. And in this case, Disney doesn't shy away from going after little guys, because once you knowingly allow one entity to infringe a precedent is set. Typically a cease & desist will be the first action taken, but I wouldn't press your luck.
Be careful out there.
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10 Things To Make You Better Than Everyone Else
The other day my wife and I were talking about my new weekly email (see: email #1) and were throwing around possible enticements to get people to sign-up. I wasn't sure I wanted to promise anything more than the weekly communication and blurted out, "I'm not sure I want to promise them 10 Things To Make You Better Than Everyone Else to get them to sign up" It was a flippant, off-hand remark that got us laughing and then I thought, "hmm. It would be fun to write." My wife cautioned that if I did it would need to be helpful too. (Always the voice of reason.)
Sign up for the email if you like. It'll be chock full of links to radio stories, audio and video, radio related pictures, plus my observations, discoveries, and insights. I promise I won't give away your information. And it's free. Let's call it viral swag. Wait! Let's not. That sounds like an STD. Let's just say if you like radio stuff as much as I do, you may like this too. For easy sign up click here.
THE LIST: 10 Things To Make You Better Than Everyone Else
1. Stop keeping score. Ironic considering the list this item appears on. But seriously, this will free you from the chains of ego – at least in part. So much of what riles us up is constantly comparing ourselves to the people around us. We compare our talents, which can be motivating. But, we also take stock of who got which desk, who got a new computer, who went to lunch with the boss, who is in the PDs office and for how long, who gets more air time, which show gets more promotion on air, who is voicing more commercials, what show got bumper stickers or billboards, who is on stage at the station concert and which bands are they introducing and on and on and on. Stop it. You're going to drive yourself insane. If you're not being treated fairly, take your official compaint to human resources. But, by fairly I don't mean equally. Not everyone gets a parking spot, a performance bonus, a cushy office, or even a free t-shirt. Be supportive of each other's success and opportunities. Trust me, if you stop keeping score and start cheering each other on you'll feel better about yourself and find your job more personally fulfilling, because of the impact your actions have on the success of your team.
2. Don't be an a – – hole. This might seem cheeky, but really there's no need to terrorize your co-workers, bully subordinates, or stride through the building like you are above it all. We all deserve better. And more and more people I talk to are instituting a "No a – – hole hiring policy." (Like this guy) So, finding and keeping your job is getting tougher and tougher if you insist on being a sphincter.
3. Be present. Physically, mentally, emotionally and spiritually (if you are inclined.) I know some will say this is mumbo-jumbo. Okay, move on. For the rest of you… being in the present moment will make you more engaged, more reliable, more likable, more productive, more balanced, more mindful and the list goes on. This means letting go of what happened last hour, yesterday or last week so you can focus on what's happening right now. It also means to stop thinking about what's next or getting emotionally engaged in events that haven't happened, but might. Sometimes the easiest way for me to shed those nagging thoughts of yesterday and tomorrow is to make a list of what's racing through my brain so I don't forget it and I can address it at a later time in a more focused, productive way.
4. Aspire for greatness. People like to be around positive people who believe dreams can come true. I actually had someone tell me after a coaching session they didn't want any more feedback on improving their show, because, "it's good enough" they just wanted me to grow their audience. What a buzz kill. When I took over as program director at ESPN in Los Angeles I was quoted in the trades predicting the station would be #1 in the market. Lots of people laughed. But at the end of the day do you want to work with people who believe greatness is possible or work with pessimists (they like to disguise themselves realists) who are satisfied with the status quo? Greatness please. I always want to work with those people who dream big and take action to achieve it.
5. Present solutions not problems. This is what I call "being an owner" or "see a problem, fix it." Too often people carry their problems across the radio station being sure to let it spill a little on everyone's desk before dumping the mess and all their attached emotions in the (insert manager position here)'s lap. This instantly relinquishes them of the responsibility of whatever is going on and leaves it up to management to solve. Or so they think. We are adults, right? Trust me, the results will be swifter and more satisfying if, before you march in and demand resolution, you consider what that might look like. I would even approach it as a pitch to solve a problem at the radio station that will; increase morale, save the company money, increase efficiency, etc. Management has enough problems to solve. If solutions are offered it's easier to act on them in a timely manner. Vice-versa is true too. Management can't tell employees to work smarter, collaborate or increase output without offering tools and solutions to do so.
6. Listen. This means actually hearing what people are saying. Studies have shown only 7% of communication is verbal, 93% is non-verbal (55% body language, 38% tone of voice.) So, put down your devices, move away from computer screens, and communicate with people face to face as often as you can. Focus on what they saying. Listen. Don't just use the time they're talking to figure what you're going to say next. Communication only works when the message sent is the message received, otherwise it is miscommunication. This also applies to listening to the radio station you work at. Hear what is going over the air tell people specifically what you like.
7. Make "what," "how" and "why" equal partners in making decisions. I'm a big proponent of strategic thinking. Knowing what you want to do, why you want to do and how it can be done seems logical enough, but in a radio station atmosphere I've witnessed more than my fair share of knee-jerk reaction decisions based on nothing but spite, fear, or an attempt to save face. Regardless if you're a board operator or the chairman of the board, keeping this in mind while making decisions is key to garnering internal support for changes. It's human nature to want to know WHY a decision is being made and if you are the decision maker you should have an answer other than, "Because." This applies to all levels of employees.
8. Give people second chances. The old adage is you only have one shot to make a first impression. But, what if we just declared that old. Some people get nervous, have bad days, always make a horrible first impression or are simply miscast. I know I'm as guilty of anyone as painting someone with a broad brush on a first impression, putting them in a box, or diminishing their value to me based on a single interaction. That's silly. Humans are fallible. Be human and realize you may be the one who made the mistake this time and give people a second chance before writing them off.
9. Be open to uncomfortable ideas. No need for any safe words here. Get your mind out of the Cosby gutter. This is about challenging conventional wisdom. This guy is doing it and I only wish he wasn't so combative, angry and intent on hording his solutions until you hire him. But this can apply to changing where you sit in the studio, what color the walls are, experimenting with new bits or talent, or rebranding a heritage station to be more in touch with the way people consume radio today. Be the guy or gal who encourages evolution. The person who says, "Yes, and…" and add to the discussion instead of shutting it down with a, "no!" or even worse, "we've never done that here."
10. Be a part of something bigger than yourself. We're in this big crazy world together so why not pitch in to help make it a better place to be. You could volunteer at your favorite charity, share knowledge with people who could use it, raise funds, raise awareness, or help find solutions to community issues. It could be as simple be creating a personal mission in how you want your actions and activities to impact others. When you are selfless in your actions the energy you exert is minimal in the scope of life, but the impact can be life changing for you and others. It also gives you a broader perspective on how your actions make a difference. And I believe when we are conscious and purposeful with our actions the impact is greater and more positive than if we take action in a vacuum and let the chips fall where they may.
And those are 10 Things To Make You Better Than Everyone Else. Feel free to share additional items, feedback and stories below.
Radio Odds and Ends
I drove a total of about 10 hours yesterday to catch up with radio friends and listen to the radio. It also gives you time to think, come up with new ideas and dream a bit. I have a renewed focus and a more positive attitude starting my day today. Here are some things I heard, saw and thought that may be of interest to you.
I heard a bunch of a election coverage. There was no greater test for my brain than flipping between NPR and Fox News Radio coverage of the midterm elections; different tone, different language, different storylines. Both were biased. Both served their audiences. Neither was misleading.
Non-stop election coverage is rewarding for anchors and reporters, but hard work. I heard national anchors and local reporters all lose their thoughts, get choked up by dry mouth, and fumble through names and issues they weren't prepped to discuss. You can't over prepare for a night like this.
I didn't hear anyone fumble and most of the coverage was informative and timely with the right level of excitement and urgency.
I saw this on the 405-South heading out of Los Angeles. I had to turn around and drive by again to snap this photo going 60 miles an hour (not recommended).
TAKEAWAY: I think KFI is threatening me.
Two points here. It's hard to be funny and I think they're trying to be funny. Humor is tough and extremely subjective. Use it with caution. Secondly, how is "stay connected" any different of a benefit from most other radio stations? Keeping listeners connected (to news, community, music, etc.) is really the goal of most stations regardless of format. It doesn't provide a differentiation point
"Best advice (I've received) is to go through life with an "F— it!" attitude. Nothing is as bad as you think it is at the time. You can survive practically anything. And the best way get through things is to realize that it's all going to pass." – Perry Michael Simon, AllAccess.com, on the Hermosa Beach Pier Plaza.
A note to the country morning show host who opens each break with the double time check (11 minutes after 7, 7-11 on your home for…) stop it. The 80's called and it want's the analog time check back please. Stick with the digital read out. It's shorter, simpler, and easier to understand. Rule of thumb: never have listeners do math in their head when you're just trying to tell them the time.
"The Mayor joins us next to talk about the election" is a programming note not a tease. Find a way to make me want to listen. Instead of WHO you're going to have on think of the WHY you WANT him on and WHAT he's going to provide that's worth sticking around for.
"There are some really good 40 second ads out there (in Los Angeles) that have been padded into a minute. If you could sell ads in multiples of :10 instead of :30s or :60s could the creative be rather better than it currently is? Because the creative of some of the ads I was hearing was not quite as high as I was hoping it would be." – Radio Futurologist James Cridland on the shores of Laguna Beach
Bring a gift. I feel both special and inadequate meeting with James Cridland. He arrived with a thoughtful gift for me and all I brought was a camera so we could take our picture together. His was more useful to me than mine to him. 🙂


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I had a reading with Orla last Wednesday. Firstly can I say what a lovely vibe in the room, Orla made me feel so welcome. Orla is a very gifted person who instantly connected with one of my spirit guides. The information passed on to me was so accurate it was like she'd known me all my life. It was of huge comfort to me to speak with my mother through Orla. After my reading, which was very impressive, I was advised which archangel to call upon for healing. I had enquired about Reiki or Angel healing sessions. Straight away a provisional booking was made for me and confirmed later that day. I am so looking forward to receiving my healing and have every confidence that my spirit will begin to heal and my life will return to what it is meant to be. I cannot thank Orla enough for the comfort she gave me and I thank God for her gift. I would recommend Angel's Love to anyone who wants to make contact with their spirit guides.
With love and thanks ~ Lisa x


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West Wight Arts Association - Constitution
The West Wight Arts Association is a registered Charity, no. 1081794. Key to our charity work is the Bursary Scheme. Our activities are governed by our constitution, which can be read below, or downloaded here.
11th May 2019
Registered Charity No: 1081794
The name shall be West Wight Arts Association, hereinafter referred to as WWAA.
The objects of WWAA shall be to promote, improve, develop and maintain public education in, and appreciation of, the art and science of music and drama in all their aspects, by the presentation of public professional or amateur performances; or for such other purposes as shall be exclusively charitable as the Trustees may from time to time decide.
WWAA will endeavour to hold a Bursary competition biennially for youngsters aged between 11 and 18 years old who live on the Isle of Wight which shall be funded to a level agreed by the Trustees from any surplus retained income.
The management of WWAA shall be in the hands of Trustees consisting of the following Officers: President, Chair, Vice-Chair, Hon. Secretary, Hon. Treasurer and up to ten other Trustees. The Trustees shall have the power to co-opt, at an ordinary Trustees meeting, further Trustees as necessary. The Trustees shall be elected at an Annual General Meeting by the existing Trustees; they shall each hold office for three years; at each Annual General Meeting elections shall take place for the re-election of those Trustees who are at the end of their terms of appointment. Officers shall be elected by simple majority at an ordinary Trustees meeting as and when vacancies occur.
No individual shall be excluded from Trusteeship of WWAA or debarred from any official capacity on the grounds of sex, gender, race, colour, age, religion, sexual orientation, physical disability or political affiliation.
A Trustee shall cease to hold office if he or she:
i) is disqualified from acting as a trustee by virtue of sections 178 and 179 of the Charities Act 2011 or any statutory re-enactment or modification of that provision;
ii) in the written opinion, given to the charity, of a registered medical practitioner treating that person, has become physically or mentally incapable of acting as a trustee and may remain so for more than three months;
iii) is absent without the permission of the trustees from all their meetings held within a period of six months and the trustees resolve that his or her office be vacated, or
iv) notifies to the trustees a wish to resign. In order to accede to such a wish, Trustees will use their best endeavours to co-opt a successor so that the Trustees remain quorate and the resignation is not delayed.
All the arrangements for the concerts and other events, and the control of finance shall be in the hands of the Trustees.
In furtherance of the objects but not otherwise the Trustees may exercise the following powers:
i) Power to raise funds and to invite contributions provided that in raising funds the Trustees shall not undertake any substantial permanent trading activities and shall conform to any relevant requirements of the law;
ii) Power to buy, take on lease or in exchange any property necessary for the achievement of the objects and to maintain and equip it for use;
iii) Power subject to any consents required by law to borrow money and to charge all or part of the property of WWAA with repayment of the money so borrowed;
iv) Power to engage such persons (who shall not be Trustees) as are necessary for the proper pursuit of the objects;
v) Power to co-operate with other charities, voluntary bodies and statutory authorities operating in furtherance of the objects or of similar charitable purposes and to exchange information and advice with them;
vi) Power to establish or support any charitable trusts, associations or institutions formed for all or any of the objects;
vii) Power to appoint and constitute such advisory committees as the Trustees may think fit;
viii) Power to terminate the Trusteeship of any individual by a simple majority of the Trustees attending at a meeting provided that the individual concerned shall have the right to be heard by the other Trustees, accompanied by a friend if desired, before a final decision is made;
ix) Power to do all such other lawful things as are necessary for the achievement of the objects.
i) The financial year shall end on 30th April.
ii) Bank accounts shall be kept in the name of West Wight Arts Association and if cheques are required shall be signed by any two of the following Officers; The Chair, the Hon. Treasurer and Hon. Secretary. Where there are online bank accounts with the bank's agreement and with authorisation of the Trustees, one or more Trustees shall be appointed to operate the online bank accounts.
iii) WWAA shall receive donations, grants in aid and financial guarantees. Tickets for any or all of its concerts and other events shall be offered for sale to the public.
iv) The Trustees shall review their financial controls annually.
The income and property of WWAA whencesoever derived shall be applied solely towards promoting the objects of WWAA as set out in Clause 2 of this Constitution and no portion thereof shall be paid or transferred either directly or indirectly to any Trustee of WWAA except in payment of legitimate expenses incurred on behalf of WWAA. WWAA shall maintain such reserves as are necessary to protect WWAA and its Trustees in the pursuance of its objects which reserves shall be reviewed annually by the Trustees.
The financial accounts shall be audited or examined to the extent required by legislation or, if there is no such requirement, scrutinized by a person who is independent of the Trustees and then submitted to the Trustees for approval at the Annual General Meeting.
The Trustees shall keep in repair and insure to their full value against fire and other usual risks all of the charity's possessions. They shall also insure suitably in respect of public liability and employer's liability.
WWAA shall adhere to all the Information Commissioner's Office's requirements currently in force and a Data Protection Officer shall be appointed.
WWAA shall appoint a Safeguarding Officer and have a Safeguarding Policy which shall be updated from time to time.
The Trustees shall hold at least two ordinary meetings each year. There must be a quorum of at least three Trustees present for business to be transacted.
Within three months of the end of each financial year the Trustees shall hold an Annual General Meeting of which at least fourteen days' notice shall be given. The Chair's Annual Report and the examined Accounts shall be approved at this meeting and copies shall thereafter be made available for public inspection.
A Meeting may be called by the Hon. Secretary if so requested by at least two of the Trustees and at least seven days' notice must be given to Trustees.
Minutes of all Ordinary, Special and Annual General Meetings shall be taken, copies sent to all Trustees and proposed, seconded and approved at subsequent meetings and held by the Hon. Secretary and such minutes will record the decisions of the Trustees and where appropriate, the reasons for those decisions.
All communications, including notices and minutes of meetings, may be made by email.
The constitution may be amended by a two-thirds majority of the Trustees present at any Annual or Special Meeting, provided that seven days' notice of the proposed amendment has been sent to all Trustees and provided nothing herein contained shall authorise any amendment which shall have the effect of WWAA ceasing to be a charity.
In the event of WWAA being wound up, any assets remaining upon dissolution after the payment of proper debts and liabilities shall be transferred to a charitable institution or institutions having similar objects to those of WWAA. The Charity Commission must be notified promptly that the charity has been dissolved and, if the Trustees are obliged to send the accounts of WWAA to the Commission for the accounting period which ended before its dissolution, the final accounts shall be sent to the Commission.
Approved by a General Meeting of the WWAA


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Surprisingly, I'm a pretty spontaneous person. Maybe it's because I struggle to plan things for other people and so over time I learned to just kind of wing it (especially when they are also spontaneous), but it doesn't bother me making last-minute plans. "Oh, I'm driving to Portland in five days and haven't found a place to stay when I get there? It'll happen, it's okay." I grew up with a compulsive questioner who, I imagine, can't stand this aspect of me. "How long will you be gone?" "What time is your flight?" "How are you getting to the airport?" "What will you eat? Do you want me to make you a sandwich?" Most of the time, my spontaneity is like deciding to go out for drinks after work, or tagging along to a party at the last minute, but other times it can be more extreme. Case in point: the Super Bowl. The Super Bowl!
It's no secret that I'm easily susceptible to peer pressure. I get cases of FOMO (fear of missing out) like no one else, and it was never more intense than when people kept telling me I should go to the Super Bowl. For a while ticket prices were so high that it was barely an idea, but as the days went by, they dropped by hundreds and hundreds of dollars. Suddenly it was a very real possibility! My cousin sent me texts nearly every day, telling me I should just bite the bullet, like he did. Everyone at work said I should go, even though the timing wouldn't be ideal. My friend who moved had her ticket, too, and it may have been missing her a lot, as well as the idea of experiencing the spectacle with some of the biggest fans I know, that finally helped me make a decision. So on Monday, after hearing from another friend that he would be in, as well, I stumbled across two "cheap" tickets (about $200 less than I had been seeing for days), and bought them on the spot. See, sometimes it pays to procrastinate! On top of that, I was able to use only miles for my flights after checking and rechecking every airfare site on the planet. Now the hotel is booked, too, really close to all the Super Bowl Boulevard action.
So I leave Friday! And I can't wait to be there with friends, bringing the 12th Man to the east coast! I've never been to New York City and haven't researched it much, so I don't know what I'll do when not doing Super Bowl things. I'm sure there will be no shortage of options, though! Packing bulky warm-weather gear into a carry-on suitcase is proving to be a challenge, so I'm going to try to wear as much as I can and be that annoying person in the security line who holds up everyone while unlacing huge boots and stripping off at least two coats. But it will be worth it when I'm not freezing all day and during the game! I'm a little nervous about the whole trip, as I always am before doing something new, and I'm going to miss my dog, but it's been an amazing season for the Seahawks and I'm so excited to be there for the end. See you soon, New York! (And please don't be too cold.)


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Sozo "Hands-On" Coaching is an opportunity to learn how to use basic sozo tools to bring freedom to your community. This is ministry school level training that is effective. You will be provided four (4) sessions of group coaching in an intimate setting where you can ask questions and readily put into practice what you're learning.
Training Dates:
November 7
November 14
November 28
December 5
Each session is held on Wednesday evenings, 7pm - 8:30pm.


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One of the best CDs to come out last year was A Frog Named Sam from Ben Rudnick & Friends.
These guys have a great band and really know how to rock. They've got a loyal following of kids and parents who love to see them play live!
Ben Rudnick & Friends will be playing at the KidsBeet concert on October 30th along with Charlie Hope, Suzi Shelton, and Rik Barron. You can learn more about the concert here.
And now's your chance to win a free copy of A Frog Named Sam so you can start rocking out before the show even starts! Simply leave a comment below or send me an email letting me know that you want to enter this contest. Hope to see you at the show!
One entry per person. CDs will be mailed to the winner. We can only ship in the US and Canada at this time.
Would you like to earn an extra entry? You can…
- Subscribe to my email or RSS updates;
- Let your friends know about the contest on Twitter, Facebook, or MySpace;
- Post about this contest on your own Blog or website;
- Add Boston Children's Music to your Blog Roll;
- or email five of your friends and tell them about this contest.
Be sure to send me an email or comment on this post to let me know what you did for your extra entry.
This contest will end Monday, October 4th at midnight. Winner will be notified on October 5th.
Good Luck!


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Item List: http://www.bfads.net/Cyber-Monday/Best- ... style=list
Item Grid: http://www.bfads.net/Cyber-Monday/Best- ... style=grid
Ad Scan: http://www.bfads.net/Cyber-Monday/Best-Buy/Ad#
24 pages
Best Buy Cyber Monday
Moderators: Tony, cematra173, killasnake, Huy
2 posts • Page 1 of 1
Best Buy Cyber Monday
That moment you realize that Bruce Jenner is Kanye Wests' mother in-law
Re: Best Buy Cyber Monday
Many of their prices are higher than current prices. Weird.
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Jennifer L. Hughes, Attorney-at-Law
Office: 2667 Camino del Rio South, Suite 301-11, San Diego, CA 92108.**
Mailing Address: P.O. Box 3183, Ramona, CA 92065-0955
*Please, no unsolicited marketing calls. This number is on the Do Not Call registry.
**No Mail is received at Office Location, so please use the Post Office Box to send mail. Office Hours by Appointment Only.
Contact Ms. Hughes via Email:


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[wpramazon asin="0789739763″]
Mobile Marketing: Finding Your Customers No Matter Where They Are Reviews
[wpramazon asin="0789739763″]
3 Comments
- 5 of 5 people found the following review helpful
Thorough, practical guide across the current spectrum of mobile marketing,
May 20, 2010ByJ. Lee "imajeel" (Houston, TX USA) –
This review is from: Mobile Marketing: Finding Your Customers No Matter Where They Are (Paperback)As a marketer for over twenty years, keeping up with all of the technological marketing medium opportunities that have emerged and continue to evolve isn't as easy as it once was. Well-focused, detailed and informative books on a specific growing opportunity, written by an expert, definitely help. This one delivers well on this front. Here's the more specific upsides and potential downsides I see, depending on your expertise and needs.
– It's a thorough and well-organized in-depth look across the spectrum of mobile marketing.
There isn't anything I can think of this book should have included that it didn't. It starts with a history and overview of the strengths and complexities of Mobile Marketing and a detailed look at how to target and track your MM audience.
Throughout the book there are great case studies. After looking into each of the different approaches that one might take with their mobile marketing efforts. It goes on to explore the international MM landscape and privacy/spam issues. There's also an appendix of supplier resources, text symbols and a glossary of frequently used terms.
– It's a practical, tactical "how to guide" too.
For each type of potential mobile marketing campaign – including advertising, promotions, application creation, e-commerce, search engine optimization and integrating it with mass media- you'll get a break down of the various mobile marketing tactics available, considerations to help you decide if that kind of effort is right for your business needs, and the best practices, instructions and resources to help you make it happen.
– You recieve free access to the on-line version of the book, w/ purchase of the hard copy.
It's a good reference that's only a click away.
– It's not going to be current for long.
One of the great things about this book is that it includes recent research and has added things like a chapter specifically dedicated to iPhone marketing – not included in many other books. But, w/ the recent launch of the iPad – there's already a new chapter waiting to be made. Some of the more specific info is just going to get outdated extremely quickly.
– It'll be easier to understand and more useful to marketers who are already fairly savvy on Internet Marketing and have worked with larger scale campaigns.
Mobile marketing opportunities, to a great extent, parallel Internet marketing ones. So, in many cases the book is highlighting the differences between the two, and it can and does get very technical. MM is also very resource intensive. This makes it more difficult currently for smaller organizations to use as efficiently – and the book really focuses on larger scale initiatives.
BOTTOM LINE: A well-written, thorough and practical guide, as well as reference book. For as long as it remains current, I highly recommend it to marketers that want a greater understanding of the potential Mobile Marketing opportunities available to their brands.
- 11 of 14 people found the following review helpful
Talk, talk talk without many action steps,
June 10, 2010ByD. Greenbaum "DoctorDave?" (Lawrence, KS) –
This review is from: Mobile Marketing: Finding Your Customers No Matter Where They Are (Paperback)Typical of someone who yaps on their phone and really says nothing, this book is mostly small talk. I left the book feeling like I read much but learned little.
Although the book was published recently, the information is simply too old to be considered relevant. I couldn't get past the fact that the author hints an an upcoming iPhone to replace the 3G, so obviously the 3GS was only on the horizon and therefore dating the information in this book to over a year ago. Little mention of Android based phones. Ideally a book written about technology should talk in generalities enough that it survives any major shift in the field. This book does not and it taints any advice given. Too many specifics focused on technology that seems outdated today.
The author spends an inordinate amount of time on how QR codes (those bar-code like cubs you've probably never seen) are used and simply assumes they'll start picking up more in the US. They haven't. Same for use of bluetooth to broadcast ads–they simply haven't picked up in the US.
If for some reason a reader wanted to start advertising via QR codes or bluetooth, she offers no practical advice on how to do it. A few examples are given on how some businesses put QR codes in ads, but not on how to create QR codes and what those codes should like to. Small and medium sized businesses simply won't know how to implement these campaigns.
SMS (text) codes are included in the book, but she certainly failed to explain how a business sets up an SMS campaign. I had hoped to learn how to do this for my business. I want customers to be able to text me and have an auto-response. No links or suggestions.
Heavy emphasis was placed on metrics software–tracking progress of your campaign. That's great if the author focused more on campaign setup. Very little emphasis was placed on mobile SEO: how to get your website noticed.
Most important, the author never really touches on how to find your customers! Finding customers assumes that these people aren't engaged in your brand. While a QR code in an ad is neat, how do you find the customers that might scan it.
Generally, this book focused on an international market and the advice given is designed for larger worldwide campaigns. The reader should already know how to setup mobile marketing materials and is simply looking for best practices on these campaigns.
Pros: Short, deals with the "big picture" of mobile marketing
Cons: Too International in focus, little practical advice, few details, outdated
- 2 of 2 people found the following review helpful
More Overview & Less How-To,
April 10, 2013BySeth Eliot (Seattle, WA, United States) –
This review is from: Mobile Marketing: Finding Your Customers No Matter Where They Are (Paperback)I wanted a book to tell me *how* to find my customers.
This was not that book.
It had a fact ton of information and from that perspective was a fascinating read. But getting into the nitty-gritty and talking step-by-step? Nope.
So if you are interested in the theory and the persuasiveness on why this is such a great avenue your company must explore? Absolutely get it. But if your hope is more on the roll-up-your-sleeves-and-let's-work-this? Not the book for you.
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Other Resources >
Changes afoot at the Malvern Hills Trust
The Public Consultation - 'Have Your Say'
What you need to do
The Public Consultation period is now half way through, so if you have not already done so it is important that you prioritise reading and commenting on the Consultation Document which can be found on the Malvern Hills Trust website.
The link to the on-line questionnaire is on the very last page of the Consultation Document. You need to click the word 'here' which is in very tiny writing, so be careful not to miss it. The questionnaire provides you with multichoice options and free text boxes so you can expand on your views; it is easy to complete. There are questionnaires on a number of topics so choose the ones relevant to you.
Click for copy of the link to the MHT questionnaire
The deadline for on-line responses is midnight on 13th October 2019.
Paper copies of the Consultation Document and questionnaires can be obtained from the Malvern Hills Trust office opposite Malvern Theatres in Grange Road.
Paper questionnaires must be delivered to the Malvern Hills Trust Office by 4pm on Friday 10th October 2019.
This is likely to be your one and only chance to comment on the proposals before they are rubber stamped by the Charity Commission and Government.
The Malvern Hills Conservators, who have adopted the working name the Malvern Hills Trust, are seeking to extend their powers by means of what they refer to as a Charity Commission Scheme; this is a Parliamentary scheme under section 73 of the Charities Act 2011 which, if approved, will lead to the amendment of the Trust's present governing documents (the five Acts of Parliament).
Prior to the Trust's formal application to the Charity Commission it is conducting a Public Consultation. This is not a legal requirement but it is a standard part of the scheme making process, as it helps to ensure that the Trustees have properly established the case for making the proposed changes in the interests of the charity and the public. The Charity Commission expects the public consultation to be a genuine and appropriate consultation exercise to take into account the views of the charity's stakeholders.
We attended a special meeting of the Board on 12th August when the Trustees agreed to start the Public Consultation on or about 2nd September 2019, to run for six weeks.
Stop press: the latest news page of the Malvern Hills Trust website reports the Public Consultation will start on 2nd September 2019 and an article in the Grapevine parish magazine lists the roadshows or drop-ins where more information can be obtained, the dates of which have been transcribed to our noticeboard.
It is most important that residents of Malvern, and surrounding villages, and the many visitors who walk on the Malvern Hills and Commons submit comments on these proposals. If you feel there are aspects which do not benefit the public you should point these out so that changes to the proposals can be considered.
The Trust tasked their legal advisers, BWB, to draw up new governance documents. To date about £109,000 of public money has been spent on this, but although the legal draft is nearly complete it appears the Trust is not yet ready to present it for public scrutiny.
The Trust is therefore offering for public comment a draft prepared by the Secretary outlining the proposals which might need amendment in the light of feedback from the public.
See What you need to do section above.
The Public Consultation documents have been placed on the Malvern Hills Trust web site. There is a summary of the proposals, a table listing the provisions of the Acts, which indicates many of the provisions are no longer relevant, and a 94 page Consultation Document setting out the proposed changes including new powers sought.
At the end of the Consultation Document is an important little link that takes you to a set of questionnaires enabling you to comment. The 'snap survey' platform has been set up by Worcestershire County Council who will collate responses and pass them to the Trust.
After completing the questionnaire you will be asked to enter your name for audit purposes, but we are told your submission will be anonymous - unless you tick the box saying you would like to be contacted by the Trust.
After the Public Consultation, comments will be passed back to the Board members of the Malvern Hills Trust, who will have the opportunity to amend their proposals before sending them to the Charity Commission.
Whether the Trust takes any notice of public representations is likely to depend on how many people respond, so it's very important you have your say.
The Malvern Hills Conservators were established in 1884 by an Act of Parliament to protect and manage the Malvern Hills and adjacent commons.
This 'framework' governing the Malvern Hills Conservators was amended by further Malvern Hills Acts in 1909, 1924, 1930 and 1995 and copies of these Acts can be found on the Malvern Hills Trust website.
In 1984 the Malvern Hills Conservators became a registered charity (number 505814).
In 2016 the Conservators decided it was time to modernise again, rebranding themselves as The Malvern Hills Trust (MHT); the change of 'working' name took place in April 2017. This seems to have come about primarily because the Board wanted to place more emphasis on the Malvern Hills Conservators' charitable status and fund raising.
We wondered how much had been spent on rebranding; for example consultants' fees, new signs and logos, building a new website, rebranding vehicles and so on, but so far we have not been able to identify a figure in the accounts as costs fell across financial years and are continuing.
The present Board members (in 2018) are now seeking new powers and a significant reduction in the number of Board members through a Charity Commission Scheme (CCS). The MHT is paying a firm of solicitors BWB a lot of money to draw up the 'Scheme', which will have to go through a public consultation process, probably in early 2019. Then the 'Scheme' will need to be approved by the Charity Commission and finally rubber stamped by Parliament, if it were to go ahead.
The consultation stage should be the first and only time most precept payers, the public and stakeholders will get to see and comment on the detailed proposals.
We think it is important you have your say.
The Charity Commission Scheme
When the Malvern Hills Acts were reviewed by Parliament in 1994 a suggestion was made that in time they should ideally be rolled into one. But politicians said they would not fund this, so the cost would probably have to be met by the Conservators.
Roll on the years and about 2016 the present members of the Board thought it time to seek to modernise the legal framework governing the Malvern Hills Conservators through a Charity Commission Scheme.
News of this was first reported in the Worcester News on 24th July 2017. To quote:
It appears that the Malvern Hills Trust then engaged a London based legal firm Bates Wells Braithwaite (BWB) to look through the Malvern Hills Acts and produce a consolidated document, adding in the new powers the Trust would like to have etc.
On 2nd May 2018 Mathon Parish Council was briefed by the Chairman and Chief Executive of the Malvern Hills Trust and details have been reported in their minutes. To quote:
On the 14th May Guarlford Parish Council was briefed by the Secretary of the Malvern Hills Trust. To quote from their minutes:
Click to open the presentation provided by the MHT to the GPC for circulation (pdf file, 1.3 MB)
The proposal that the number of Board members should be reduced from the present 29 to 12; of whom only 6 would be elected may be contentious. We wonder if that is appropriate for a public body, and suggest the rationale for that needs to be explored, and if necessary challenged.
Expenditure on the Scheme
The Malvern Hills Trust budgeted £100,000 for this work, but at the Board meeting in September 2018, it was noted that £85,000 had already been billed by BWB, and in the light of this the Chairman agreed to the budget being increased to £145,000.
When asked what what would happen if that wasn't enough the Chairman said that the Finance Committee should come back to the main Board.
It does seem the MHT is spending an awful lot of public money on 'paperwork', and one wonders exactly what the overall cost and benefit will finally be.
It is not clear to us from which account the money is being drawn to pay for all this, and what cannot be afforded in consequence.
The Charity Commission will require the Malvern Hills Trust to hold a properly advertised and robust Consultation.
As of October 2018 probably the majority of people living in the Malvern Hills area will not have heard of the Charity Commission Scheme although preliminary briefings have been given to parish councils - though not for some reason to Malvern Town Council.
The Trust had been expecting the Consultation to take place over 6 to 8 weeks starting in either December 2018 or January 2019, but this has slipped to September, partly due to the government's focus on BREXIT.
As far as we know the Malvern Hills Trust are not currently planning to give presentations but will be offering drop in sessions where the public can view the documents and ask questions. The volume of the final scheme is expected to be between 130 and 160 pages of A4; an executive summary is planned.
Public comments will then be fed back to the Trust and the Charity Commission who will review the proposals and then pass the final version to government. It currently seems that the Department of Culture Media and Sport will be happy to pass this on for rubber stamping without parliamentary oversight, assuming there will be nothing to embarass the minister, so it is important precept payers look through the proposals with a fine toothcomb, and inform the Trust and Charity Commission of any concerns.
The Malvern Hills Trust had hoped to have the new legislation approved before the next elections to the Board, which are due to take place on 31st October 2019, but that now appears unlikely.
Points to ponder
Currently we have not seen the 'Statement of Need', which presumably must have been shown to the Charity Commission, and the Department of Culture Media and Sport, nor have we seen the instructions given to the Malvern Hills Trust's solicitors BWB. Nevertheless there are some points the public might like to think about.
Reduction in number of Trustees
We think very strongly that the number of Trustees should remain the same in order to preserve public accountabilty. Also from a practical point of view a large number of Trustees is required in order to run the various Committees and cover the workload taken on by volunteers.
Accountability and transparency
Between about 2009 and 2011 the Malvern Hills Conservators attempted unsuccessfully to evict their tenant from St Ann's Well. A lot of public money was wasted and the Conservators were censured by the Charity Commission for mishandling the matter, and lack of transparency.
In 2018/19 precept payers on the Guarlford Road were asking questions about an easement requested from Chance Lane into a field known as Rose Farm, and similar criticisms about lack of transparency emerged even though the MHT says it 'seeks to act in-line with the FOI Act'.
The Guarlford Road
As a small charity the Trust is not subject to the Freedom of Information Act, but we propose that stronger words should be written into the Charity Commission Scheme along the lines:
"The Trust shall act as though it were subject to the Freedom of Information Act".
This is especially needed as the MHT is proposing to reduce the number of accountable Board members.
Since precept payers are forced to fund the Malvern Hills Trust through their Council Tax, one might have thought that the Trust would have to take into account the opinion of local residents, for example, expressed through Malvern Hills District Councillors nominated to the Board. We also thought Board members might have some loyalty to the precept payers who elected them, but the Chairman of the MHT has made it quite clear that the Board member's loyalty is only to the Trust, with no regard to the people who fund them. That seems wrong. No taxation without representation is a principle we think the board should reflect on.
Looking at governance more widely it seems the Board member elected by the Chase Ward had not attended meetings for almost three years, and although that is a breach of the guidlelines in the MHT's Governance handbook, the Trust did nothing about it.
Unlike his predecessor, the Board member elected for Guarlford has not attended any Parish Council meetings in a liaison role.
The Chairman of the MHT has made it clear that, in his view, when granting easements, the MHT cannot consider the impact of their decisions on adjoining land. So, for example, it appeared that the MHT was negotiating with a developer, threatening to damage the beautiful gateway to Malvern, which another body, the Malvern Town Council, wanted to protect.
We wonder what the Charity Commission Scheme document might say about such matters.
Public questions
The public can attend most meetings of the Trust, but generally questions have to be submitted in writing at least three days before the meeting. The Trust seem inclined on occasion to read out the questions and give prepared answers without allowing the public a right of reply.
We get the impression, rightly or wrongly, that the Board of the MHT don't consider themselves accountable to the public in any way.
The Trust are now proposing that in future the public should be excluded from Committee meetings.
Timeliness of minutes
The Trust are dutiful in making minutes available on the Trust website, but often not until immediately before the next meeting.
We suggest the Charity Commission Scheme ought to require draft minutes to be placed on the Trust's website within 4 weeks, as the government mandates for Parish Councils.
Cash versus conservation
Certain Board members now seem to be taking the view that some detriment to the Malvern Hills is acceptable if the price is right, thinking that the Charity Commission guidance empowers the MHT to override the Malvern Hills Act 1995 and make 'Cash King'.
The MHT think this is permitted by Charity Commission guidance document:
It's your decision: charity trustees and decision making
Click to read the guidance often referred to as (CC27)
But to us the situation is less clear. Another interpretation is that the prime directives of the Malvern Hills Acts are more important.
Strangely if you type 'complaints' into the search box of the Malvern Hills Trust you will get no results. However you will find a link to the Complaints Procedure at the bottom of the Contact Us page.
The Complaints Procedure does not use the word Ombudsman to whom one can go if not satisfied with the Board's response, although there is an inference that this is the Charity Commission. Though if you go to the Charity Commission website it appears they won't want to get involved unless the complaint is extremely serious.
So we suggest that the role of an Obudsman needs to be defined in the Charity Commission Scheme.
Do let the Malvern Hills Trust know if you have any concerns about the Charity Commission Scheme.
St Ann's Well
Recently renovated at a cost of about £200,000
Last updated 21st September 2019


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Lima Tie Side Mia Swim Bottom
$ 42.95
Brand Body Glove
Lima Tie Side Mia Swim Bottom
A trip to Peru is never complete without a visit to the local artisan markets. With treasures like hand-woven tapestries, totes, throws, and ponchos, we love filling our suitcases to the brim with these colorful handicrafts. Named after the country's capital, our Lima collection was inspired by the intricacy of local folk art like weaving and beading. Unquestionably eye-catching, the swimmies in this series have an almost knitted look to them, and with multi-colored elastic strap detailing inspired by dream catchers, its pieces will mesmerize anyone who lays their eyes on you.
- Mid rise
- Tie side
- Mid coverage
- Model is wearing a size X-small bottom


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Eat, Drink & Repeat | March 4-10, 2018
Celebrating 10 Years of Delicious Food and Crafty Cocktails…
Added by OCfoodies on February 27, 2018 at 9:02pm — No Comments
Chef Cathy Pavlos' legendary Sunday Supper is making its comeback on Sunday, March 25th as she presents "A Sunday Supper That My Grandmother Would Have Done." Modeled after her own family dinners every Sunday since the 1950s, this Sunday Supper is being held on Grandma and Grandpa Bottari's Wedding Anniversary and will feature a four-course menu served family-style featuring…Continue
Added by Kelli on February 23, 2018 at 11:00am — No Comments
The Ducks hosted the 18th annual Dux in Tux on Thursday, February 22 on the ice at Honda Center.
This event is dedicated to raising funds for the Anaheim Ducks Foundation. The night featured some of Orange County and Los Angeles' most renowned chefs, each of whom donated their time and talent to the cause.…Continue
Added by OCfoodies on February 23, 2018 at 11:00am — No Comments
It is often asked whether there is also a certain diet that has fat-burning properties. They are sure! This list of healthy foods helps you lose weight faster and burn fat faster. The best result is achieved when you are losing weight. Your body will then appeal to fat reserves and with some updates in your diet will burn even more fat. You will therefore have more results from the same effort, thanks to fat-burning foods. Let's start with Top 10 fat-burning foods.…Continue
Added by Misty Jhones on February 22, 2018 at 1:11pm — No Comments
Bad to the Bone BBQ is growing, with the opening of a 1,700-square-foot Event Center and the addition of a General Store for grab-and-go and other offerings. The new Event Center includes a full bar and outdoor patio, offering various options for semi-private gatherings large and small, including wedding receptions, banquets, birthdays and more. Plus, events are fully…Continue
Added by Kelli on February 21, 2018 at 11:07am — No Comments
Medieval Times has announced that a queen is now in charge and sole ruler of the land. She is cast as a firm but kind ruler respected throughout the kingdom who inherited the throne at the passing of her father, the previous king.
The company's leadership developed the idea to cast a matriarch, based in part on guest feedback that they would like to see women having…Continue
Added by Kelli on February 21, 2018 at 11:00am — No Comments
ADYA is excited to introduce Guest Chef Collaborations at ADYA Anaheim, and for the inaugural dinner, ADYA welcomes Puesto Chef Katy Smith to present "From Mumbai to Mexico City!" The dinner will be held on Thursday, March 29th at 6 p.m. and feature 5 courses that showcase each chef's individual style, as well as feature two courses that combine the authentic flavors and…Continue
Added by Kelli on February 15, 2018 at 10:48am — No Comments
One of the most popular events in Orange County, get ready for a fun and festive evening where a group of OC's best chefs and restaurants each prepare wildly innovative and crazily delicious tacos. The chefs' creativity is endless and the all-you-can eat food, paired with margaritas and beer, leaves guests talking for the rest of the year!
Don't miss the pre-event VIP…Continue
Added by Kelli on February 15, 2018 at 10:38am — No Comments
Featured $10 Cocktails Honor OCRW 10-Year Anniversary
OC Restaurant Week is March 4-10, 2018
Orange County Restaurant Week is celebrating its 10th Anniversary beginning Sunday, March 4th through Saturday, March 10th. In…Continue
Added by OCfoodies on February 13, 2018 at 3:48pm — No Comments
Celebrate Valentine's week (February 9-18, 2018, 5-10 p.m.) with a special four-course prix fixe menu featuring a choice of 8-oz. filet mignon or barbecue king salmon paired with a duo of colossal shrimp or king crab legs. Both entrées include a…Continue
Added by Lauren on February 8, 2018 at 4:00pm — No Comments
For Valentine's dinner, February 14, 2018, 4-10 p.m., TAPS will offer a chef-inspired three-course prix fixe menu with choices. Starters include a dish such as Pacific oysters, charcuterie plate, Maine lobster dumplings, jumbo shrimp cocktail, grilled octopus and…Continue
Added by Lauren on February 8, 2018 at 4:00pm — No Comments
Sundried Tomato American Bistros and Catering has announced a new Mexican-American fast-casual restaurant near its flagship restaurant. Bueno Bueno Mexican Kitchen is designed to offer a culinary destination featuring contemporary Mexican cuisine in an attractive and fun environment under the theme "PANZA LLENA, CORAZON CONTENTO" (Full Belly, Happy Heart). Simple, fresh,…Continue
Added by Kelli on February 8, 2018 at 2:25pm — No Comments
This year indulge in BRIO Tuscan Grille's tempting Valentine's Day menu. This amazing menu includes enticing cocktails, delicious starters and entrées, plus a decadent dessert, it's the perfect way to treat your special someone this Valentine's Day. BRIO Tuscan Grille locations at Victoria Gardens in Rancho Cucamonga, and Irvine Spectrum Center in Irvine, will offer this…Continue
Added by Kelli on February 8, 2018 at 2:08pm — No Comments
Experience everything Mardi Gras with New Orleans-inspired fare and cocktails during the month of February at House of Blues Anaheim Restaurant & Bar. With discounted specialty dishes like the House of Blues signature Voodoo Shrimp alongside a signature cocktail like the Bourbon Street Mule. All New Orleans-inspired items will include a special $2 discount through the end…Continue
Added by Kelli on February 8, 2018 at 2:00pm — No Comments
Tuesday, February 13th, join Snooze, an A.M. Eatery and breakfast lovers across the country and celebrate International Pancake Day. Snooze is offering a showcase-style menu of seven exclusive, sweet & savory pancakes. The flight-sized flapjacks will be priced at $4.50 each, including: Cherry Chocolate Pie, Whiskey Cake, and Just In Queso made with a cornmeal pancake with…Continue
Added by Kelli on February 6, 2018 at 10:00am — No Comments
You are invited to the 25th Annual Wild & Crazy Taco Night on Thursday, April 12th at Share Our Selves in Costa Mesa. More than 25 of Orange County's most celebrated chefs will join an expected 700 supporters of SOS for a casual evening of beer, margaritas and unique and delicious tacos.
See your favorite OC chefs at their most creative as they compete to come up…Continue
Added by Kelli on February 1, 2018 at 1:50pm — No Comments
San Diego's Breakfast Republic, is coming to Orange County in late fall 2018. Known for its menu items and quirky breakfast-inspired décor, this popular morning destination has grown at a record rate since the opening of its first location in San Diego in 2015.…Continue
Added by Kelli on February 1, 2018 at 1:33pm — No Comments