text: Guys: We have always used a drip coffee maker but things have changed a bit lately. A relative got us a coffee grinder last year for Christmas and it opened my eyes. So recently I got a Revere Ware percolator for the stovetop. It makes smokin' hot coffee compared to (a very good) drip maker. I grind it very coarse so little of the grounds go through the metal holder. Let it perk seven minutes; shut it down; lift out the very hot innards and set aside; then pour myself the most amazing cup I've ever had. Am I all alone in the Perc World? Where is it in the pecking order of coffee making? Down at the bottom or in the middle? Any tips for a perc newbie? In keeping with the, "It didn't happen if there aren't pics" here it is. A pre-1968 model with thick copper bottom, actually quite mintish.


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Teen Sexting Can Be Warning Sign of Other Risky BehaviorsBy Dennis Thompson
HealthDay Reporter
MONDAY, June 17, 2019 (HealthDay News) -- Parents who find a sex-based text on their teenager's phone should be on the lookout for other problems in their child's life, a new evidence review suggests.
Teens who share sexually explicit images are much more likely to be involved in other troubling activities, including unsafe sex, alcohol and drugs.
"The kids who are sexting are engaging in a lot of other risky behaviors," said senior researcher Sheri Madigan, a child development expert from the University of Calgary in Alberta, Canada.
"We found that youths who were sexting were approximately four times more likely to be also engaging in sexual intercourse, five times more likely to have multiple sexual partners, and half as likely to be using contraception," she continued.
Also, sexting teens were:
- Twice as likely to have symptoms of depression and anxiety.
- Two and a half times more likely to be smoking or engaging in delinquent behaviors like stealing or vandalism.
- More than three times as likely to be using alcohol or drugs.
But the findings are particularly troubling in light of a 2018 study led by Madigan that found 1 out of 4 teens is receiving sexts, and 1 out of 7 is sending them.
Results from the new review line up with what is already known about teens and sexting, said Sameer Hinduja, co-director of the Cyberbullying Research Center at Florida Atlantic University.
"Many risky behaviors among youth tend to occur in a constellation," he said. "If a teen experiments with one risky behavior, that teen typically has experience with other risky behaviors."
For this study, Madigan and her colleagues collected and combined data from 23 previous studies on sexting, involving nearly 42,000 teenagers.
They found significant links between sexting and sexual activity, risky sexual behavior, symptoms of mood disorders, drug and alcohol use, smoking and delinquency.
Further, they found that associations between sexting and either sexual behavior or mood disorders were stronger in younger adolescents, compared to those in their later teens.
It's not clear whether sexting leads to these behaviors, or whether kids inclined to take risks are also more likely to sext, the researchers added. They noted the findings could not prove causation; it only showed an association.
It's very possible that sexting is a gateway that could lead to more experimentation with sex, Madigan said.
"I think sometimes sexting is an initiation into greater sexual behavior," she said. "Sometimes kids use sexting as a starting point. People have called it the modern-day version of flirting."
But other research also has found that when teens are sexting within the confines of a committed relationship, they are not more likely to be engaging in substance abuse and other risk-taking activities, Madigan added.
Those associations are more often found in "youth who are sexting as a method of flirting or sexting in a more casual way," she said.
So what should parents do?
Hazing and cyberbullying expert Susan Lipkins said the "pat answer" is to remind children that anything they share over the internet is out of their control and could be used against them.
Parents should start teaching their kids about privacy and consent as early as possible, even before they have a phone, she and Madigan advised.
Such conversations should include discussion of "what-if" scenarios, Madigan said: What if someone sends you a photo? What if you're asked to send a nude of yourself? What if someone tries to coerce you into sexting? What if you share a nude with a boyfriend or girlfriend and then you break up?
"But the truth is, the kids will learn all that, they will memorize it and repeat it back to you, and then they will do whatever they want," said Lipkins, a psychologist in Port Washington, N.Y.
The best thing adults can do is create a system for reporting sexts and other cyberbullying behavior, one that is anonymous and allows for verification of complaints, she said.
Otherwise, it's really in the hands of the teens themselves, she added.
"The kids themselves have to decide they don't want to participate," Lipkins said. "'We're not going to pass that photo along. No, I don't want it on my device. No, I don't want to get in trouble for having it. No, it is inappropriate, it is disrespectful to whomever, and I'm not going to participate in this behavior.' When they can say that and protect each other and themselves, that's when it's going to end."
The new report was published June 17 in JAMA Pediatrics.
More information
The Nemours Foundation has more about sexting.
This article: Copyright © 2019 HealthDay. All rights reserved.
- Adventures in Parenting
- Introduction to Adventures in Parenting
- So where do we start?
- RPM3: How responding, preventing, monitoring, mentoring, and modeling can help you be a successful parent
- Responding
- Prevention
- Monitoring
- Mentoring
- Modeling
- Now what should I do?
- Under 3
- Under 3: Responding
- Under 3: Prevention
- Under 3: Monitoring
- Under 3: Mentoring
- Under 3: Modeling
- Between 4 and 10
- 4 to 10: Responding
- 4 to 10: Prevention
- 4 to 10: Monitoring
- 4 to 10: Mentoring
- 4 to 10: Modeling
- Between 11 and 14
- 11 to 14: Responding
- 11 to 14: Prevention
- 11 to 14: Monitoring
- 11 to 14: Mentoring
- 11 to 14: Modeling
- RPM3 Summary
- References
- Infants: Parenting and Child Development
- Early Childhood: Parenting and Child Development
- Adventures in Parenting
- Don't Let Kids Wander Alone in Parking Lots
- Most U.S. Parents Say Vaccination Should Be Requirement for School: Poll
- Nurturing Childhood Boosts Odds of a Happy Adult Life: Study
- Is a Charter School the Right Choice for Your Child?
- Backpacks Shouldn't Be a Back-to-School Burden on Health
- 5 Health Tips to Promote Back-to-School Success
- Older Parents May Have Better Behaved Kids
- What Happens to the Children When Parents Fight?
- Parents Who Belittle Their Children May Be Raising Bullies
- 'Failure to Launch': Poll Finds Many Older Teens Still Too Reliant on Parents
- 38 more
- How to Help When Your Child Weighs Too Much
- Parent Who Listens Can Help Kids Thrive Despite Trauma
- Will Video Games Make Your Kid Obese? Maybe Not
- Teen Sexting Can Be Warning Sign of Other Risky Behaviors
- Tips for Keeping Your Child Healthy at Camp
- Best Gift From Dad for Kids: More Time Together
- 'Dad Shaming' Is Real, Survey Shows
- How to Put Limits on Your Family's Screen Time
- Hundreds of Young Kids Drown in Pools Each Year -- Keep Yours Safe
- AHA News: With Summer Vacation Here, How Much Screen Time Is Too Much?
- How Kids Benefit From Doing Chores
- Opioid Prescriptions to Teens, Young Adults Still Common
- Does Taking Screens Away Help Sleep-Deprived Teens?
- Health Tip: Children and Pets
- Does Your Sunscreen Work for You?
- Who's Most Likely to Miss School Due to Eczema?
- 2 of 3 Parents Read Texts While Driving
- How to Tame Morning Chaos
- How Much Does Your Kid Weigh? Chances Are, You're Underestimating
- 3 Parenting Essentials to Safeguard Kids' Well-Being
- Can Games and Apps Help Your Kids Learn?
- Teaching Kids the Importance of an Apology
- The 1-Parent Family and Kids' Health Risks
- How to Stay Close as a Couple Now That Baby Is Here
- Single Moms Often Put Kids' Health Care First, Study Finds
- Taking a Bite Out of Food Ads Targeted to Kids
- Head Off the Blues When Your Teen Heads to College
- Health Tip: Becoming a Step Parent
- Health Tip: Talk to Your Kids Early About Alcohol Use
- The Reality of Watching Reality TV
- Almost All U.S. Teens Falling Short on Sleep, Exercise
- Movie Violence Doesn't Make Kids Violent, Study Finds
- Gay Dads and Their Kids Still Face Social Shaming
- Parents, Think Before You Drink This Holiday
- When You Go From a Family of 3 to a Family of 4
- Navigating New Parent Nerves
- Pediatricians Renew Call to Abandon Spanking
- Try Small 'Bites' to Get Kids to Exercise
Self-Help Groups
- Positive Behavior Support: Making Clear and Effective Requests
- Monitoring and Limit Setting: Clear Rules
- Bullying Prevention: Lessons from Research and Practices
- Boys & HPV Vaccine
- Button Batteries Sending Kids to the ER
- Accident Proofing Kids
- Teaching Kids to Get Moving
- Kids and Brain Strain
- Risks in Delaying Childhood Vaccinations
- Are Kids Getting Enough Sleep?
- 30 more
- Most Kid's Fevers, No Worries
- Vaccination: A Key Piece of the Puzzle
- Babies on the Move: Protecting Babies with Vaccination
- Children and Parents in the Age of Medication
- Dipping into Swim Safety
- Sick Kids: Viral vs. Bacterial
- Focusing your Children on Fitness
- Parents Slow to Recognize Obese Children
- Monitoring and Limit Setting: Privilege Removal
- 3 Easy Tips to Get Children Active
- NAMI's Ask the Doctor Calls--Dialectical Behavior Therapy
- All in On Water Safety
- The Sound of Your Voice
- Finding Effective Mental Health Treatment for Children
- Helping Children with Divorce
- Preventing Death by Suicide-Strategies to Help Children, Youth and Families
- Vaccines: Separating Myth from Reality
- Back to School: Dr. Stephen Whiteside on Routines
- Dr. Bridget Biggs on Bullying
- Weight Control For Children: Improving Physical Activity
- How to Talk to Teens: A Developmental Approach
- 6 Top Tips for Parents
- Bipolar Mom Struggles With The Daily Routine
- Stop the Chaos! Tips for Creating a Peaceful Household When Mom has ADHD
- Common Childhood Illnesses & Immunizations
- Positive Parenting & Promoting Mental Health
- Childhood Obesity & Healthy Eating
- Home life when Mom or Dad has ADHD: Succeeding with your family
- The Long term Impacts of Bullying
- Preventing Childhood Obesity
More Information
- Wise Counsel Interview Transcript: An Interview with Amy J. L. Baker, Ph.D. on Parental Alienation
- Wise Counsel Interview Transcript: An Interview with Annie Fox on Parenting 21st Century Teens
- Wise Counsel Interview Transcript: An Interview with Marsha Temlock, MA on Adult Child Divorce
- Wise Counsel Interview Transcript: An Interview with Sarah Chana Radcliffe, M.Ed., C.Psych.Assoc. on Raising Kids without Raising Your Voice

subset: commoncrawl


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Hours of Operation, mon-Sun 24 Hours, mon-Sun: 24 Hours, amenities.
Train Closest stop is South Brisbane station.
Our 100 Commitment to Accessibility We constantly endeavor to improve accessibility to all our guests and any comments you have would be most welcomed.
Please pass in your comments to any of our staff or contact us on or email.Please view our access map for the car park entry locations.Private Vehicle We provide 24 hour undercover parking with a total of 1500 parking spaces.Car parks can be accessed from Merivale, Melbourne and Grey streets.If you have any special requirements contact the Centre on or email, access Guide, bCEC Access Guide has information on accessing our building and services.All accessible toilets have hand basins and are christening gifts for 4 year old boy fitted with handrails with a monitored emergency duress system installed.Guide, Hearing and Assistance Dogs are welcome in our venue.External stairs provide access to the Great Hall and Exhibition Halls.Lifts Internal lifts have braille signage meal fix promo code and control panels that are at a convenient height for people in wheelchairs.There is a drop off area in Glenelg Street, which offers protection from the weather.Box Office Special Needs Booking Line direct on (07), between.30am- 5:00pm Monday to Friday.This access statement is intended to provide information for all guests who wish to or use our facilities.Each lift is fitted with an emergency button and an emergency telephone and has audible and visual cues to indicate floor levels Getting Here Transport Plan your journey Walking distance Approximately 3-5 minutes from all accessible public transport stops.Bus Closest stop is Cultural Centre station.Printed copies are also available at our Information Desks.
Covered Parking, open 24/7, credit Cards Accepted, non-restricted 1500.
Lifts operate between pavement level on Merivale Street and the main concourse on exhibition level.
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These animals have been either: accredited under a law of a State or Territory that provides for the accreditation of animals trained to assist a person with a disability to alleviate the effect of the disability; or accredited by an animal training organisation prescribed.
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text:
Ireland boss Joe Schmidt is hopeful Tadhg Beirne could return to fitness in time to face Italy in Rome when the defending champions resume their Guinness Six Nations campaign in 13 days.
Resources in the Irish second row have been hit by the absences of both Munster's Beirne and Ulster's Iain Henderson from the first two rounds while Schmidt has also lost lineout leader Devin Toner following surgery last week on an ankle injury suffered against England.
Connacht's Quinn Roux, forming a second-row partnership with James Ryan, called the lineout as Ireland completed a 100 per cent return at the set-piece while also successfully disrupting Scotland. Yet a fit-again Beirne, out since a knee injury in Munster's European win over Exeter Chiefs on January 19, will be a major boost with Henderson's return from a dislocated finger not expected until round four at the earliest.
Asked about players returning from injury ahead of the round-three trip to Italy on Sunday week, Schmidt: "I think Tadhg wouldn't be far away."
No.8 CJ Stander is ruled out due to facial injuries, but there could be comebacks for centres Robbie Henshaw (dead leg) and Garry Ringrose (hamstring) while back-three player Andrew Conway could also return from a calf problem that saw him return to Munster last week for rehabilitation.
Scrum-half Kieran Marmion is another close to a recall, having been ruled out since undergoing ankle surgery after starting against the All Blacks last November.
Schmidt was satisfied Johnny Sexton was in a good place immediately after the match having failed his Head Injury Assessment midway through the first half. He believed Sexton may have been stamped on accidentally by a team-mate before a heavy landing moments later ended his participation on 23 minutes but said: "He's pretty good now so we'd be pretty confident that he will bounce back pretty quickly. And we're always going to err on the side of caution with those."
Roux, meanwhile, was delighted to have taken his opportunity, though he looked out on his feet as he hobbled off the field on 67 minutes, replaced by fellow Connacht lock Ultan Dillane. "It was something that I've done with Connacht for the last two years so it's something that I've got a lot of confidence in at the moment and I was allowed the opportunity to do it on the biggest stage and I think it went really well"
Moreso having been omitted from the original Six Nations squad. "I was disappointed, to be honest, I thought I had a really good November series. I did well and I had called the lineout really well against Italy and the USA but sometimes decisions don't go your way. But rugby is a funny game, one week you're not in and the next week you're starting against Scotland in a massive Test. I'm glad I got the opportunity and made the most of it."


text:
- 3 beds
- 3 baths
- $1,275,000 price
- 557270 mls id
- Square Feet: 2,927 sqft
- Year Built: 2005
- Neighborhood: Acrg Nonsub
- Status: Active
THIS HOME IS TRULY REMARKABLE! Gorgeous 2 Story LOG CABIN situated on 36+- acres The beautiful home has hickory flooring throughout, a stone fireplace as the centerpiece of the living area, wrap-around porch, 2/2 on the main floor, and 2/1 plus a loft upstairs. The gourmet kitchen features granite counter tops, custom wood cabinets, gas stove, plus a wine cooler. Outside, relax to the sound of the flowing water that leads to a wading pool. The yard around the home has been meticulously landscaped. A large equipment barn with 5 roll up doors, full bath and laundry area. Horse Barn with 11 padded stalls, office & tack room, and 1/2 bath. 2 riding arenas, 6 individual grazing pastures, Hay barn, along with 3 RV hookups. Fenced and cross fenced. Gated entrance and paved driveway.
- Property SubType Single Family Residence
Related Listings
47 Pictures
This farm is located in pristine Area of Levy County , with WEC just around the corner, you can have a serene farm and a custom home. Country style farm house includes, wide plank floors, fireplace, french dual stove within a spacious kitchen, custom master bath with a marvelous master bed and...
13871 NE 14 Lane Williston, FL
3 beds, 3 baths, 3,004 sqft, $1,199,000
Listing Agent: Carla Lord
Courtesy of: OCALA HOMES AND FARMS
Courtesy of: SMITH & ASSOCIATES INC
Office Phone: +13525290010
Listing Agent: Brad Smith
Updated: 22nd September, 2019 8:34 AM.
1451 NE Highway 41 Williston, FL


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October 17, 2018
Winter Garden: 5 ways to prepare yours.
Winter Garden: 5 ways to prepare yours. Yes, a winter garden is possible, and winter plants do exist. It is easy to think of gardening as purely a summer activity, enjoyed while the sun is shining bright on our well-tended lawns, but maintaining a healthy winter garden...Read More


text:
We are not robots but, we understand the search robots and how they can be helpful to us. Our talented and well-experienced team proudly takes the responsibility of building your brand. We take an honor to make your business grow globally, regardless of its current situation. You can be a startup, a mid-size organization or even a large scale business, if you think there's always a scope of improvement then we will do it for you.
Our awesome team builds effective digital marketing strategies to generate your goodwill in the market. You can find problem solvers, self-motivated creators, coders, designers, writers, auditors in one place.
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Sean and Liz Whelan are a loving, hardworking Australian couple faced with a cruel and heartbreaking dilemma.
With their family at breaking point from the violence of their severely autistic son, they're making impossible decision – to give up their son or split up their family.
Diagnosed with severe autism at just 20-months-old, Max's complex disability means he is completely non-verbal.
Max struggles to communicate and becomes unfathomably frustrated, which results in frequent, unpredictable, violent meltdowns in which he harms himself and anyone around him.
His siblings – Tom, 13, Harry, 9 and Georgia, 7 – have taken to locking themselves in their rooms, fitted with special combination locks, for their own protection.
The Whelans love and adore Max and cannot imagine ever having to relinquish him. But what do you do when love isn't enough to protect your family?
Tonight on 60 Minutes, reporter Liz Hayes goes inside the Whelan home to discover what life is really like living with a severely autistic child.
"Liz and Sean Whelan are a young couple like so many others, with four kids just trying to do the best they can," Hayes reflects.
"But what many have not known, not even work mates and neighbours, is that their gruelling private world has been at times a nightmare. "
It's there she learns the unthinkable – and heartbreaking – action the family have been forced to take to save Max and themselves.
"Where we've arrived - at the point that we are - it makes it so difficult because we all love Max so unconditionally," Ms Whelan tells Hayes.
"We love him, there's no conditions on our love for him. But there's conditions on our safety."
For all Hayes had learnt about the challenges the family faces, nothing prepared her for witnessing Max's meltdowns in person.
60 Minutes cameras were rolling when Max had a sudden, violent outburst directed at his Mum.
"As frightening as Max can be, this is a story about the unshakable love of parents who can't turn their backs on their son," says Hayes.
"I asked if it was hard to love Max, and their immediate and definitive response was 'No'."
The Whelans have spent hundreds of thousands of dollars exploring every possible therapy, treatment and intervention to help Max but nothing has seemed to work.
They have been left financially and emotionally devastated.
Their extended family and friends have become increasingly concerned watching Max's meltdowns worsen as he hits puberty and grows in size and strength.
"It's a child you're dealing with, with the strength of a man," says Mr Whelan's sister, Nicky.
"It's really scary."
Finally, they decided it was time to intervene.
'The plan' as the family refer to, is for Ms Whelan and her other children, Tom, Harry and Georgia, to move out of the family home to safer accommodation in the hope of transforming the family home into a private treatment centre for Max.
It's an extreme measure – and without government assistance, very expensive - and was a heartbreaking decision to make.
"I felt so deeply for both Sean and Liz," says Hayes.
"They're faced with an impossible decision - give up Max or split the family.
"Sean and Liz would like people to know what it means to live with children like Max. They don't want pity, they want understanding and help."
'Maximum Love' airs tonight on 60 Minutes, after Australian Ninja Warrior on Channel 9. For more on 60 Minutes, head to 9NOW.
© Nine Digital Pty Ltd 2019


text:
Garden Grove Fire Department
Contact Information
Garden Grove Fire Department
11301 Acacia PKWY
Garden Grove, CA 92842Mailing Address
Garden Grove Fire Department
11301 Acacia PKWY
Garden Grove, CA 92842
Phone: (714) 741-5600
Fax: (714) 741-5640
Dial 911 for Emergencies!
Fire Chief
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No volunteer recruitment information provided.
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"To promote Performance Excellence through rapid response, proactive training, prevention, and preparedness programs, while maintaining a high level of efficiency and well-being for our community.
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Fire Department Statistics
Department Type: Career
Number of Stations: 7
Firefighting Personnel
Full-Time Paid Firefighters: 97
Part-Time Paid Firefighters: 0
Volunteer Firefighters: 0
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Non-Firefighting Paid Staff: 3
Non-Firefighting Volunteers: 3
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text:
Hey there, I'm Cherrie!
Hi girls! I am a lifestyle blogger located in the Durham Region in Ontario who enjoys sweet scents, all the beautiful things that life has to offer, warm snuggles with my sweet lil' daughter; Harper and coffee...let's not forget about the coffee. Born & raised in Toronto, I am so obsessed with all the fashion, beauty, and food that this beautiful city has to offer. I am in my natural habitat when I am sipping on a warm cup of coffee (which does not happen often when you are a mom of a busy toddler), playing with makeup, and dressing up like I have somewhere fancy to be.
I would describe my personal style as minimalist & feminine which translate to my photography as well. I love dressing up my outfits/styling my images with accessories/props that'll allow me to bring own personal flare. I've been wanting to start a blog for a full solid year but I had let fear stop me from doing so until now. I've decided to jump in with both feet without looking back and I am beyond excited to see where this will take me.
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Cardinals wideout Larry Fitzgerald 'focused on' football, not retirement
The Arizona Cardinals franchise went through some drastic changes during this NFL offseason. Following the 2017 campaign, the team lost quarterback Carson Palmer and head coach Bruce Arians to retirement. Future Hall of Famer Larry Fitzgerald was thought to follow those two by also calling it a career.
However, after taking some time to make his decision whether to return, Fitzgerald chose to come back for at least one more season in Arizona. Now the 34-year-old superstar wideout is completely focused on football, via Darren Urban of the team's website.
"It's professional sports, and you think you have an idea but you really have no idea," Fitzgerald said Sunday morning. "There's retirement and then there's being retired. Most guys get retired. (The teams) tell you it's time to go to pasture. You have to figure it out and they give you your apple and a road map.
"For the last 10 years I've been doing internships and those types of things to prepare myself and figure out what I am interested in and what I want to do when I transition out. (But) this is my focus right now. End of July to the beginning of February, the only thing I'm really focused on is ball."


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1981 Francis Hughes, Irish political prisoner, dies on ways to win connect 4 hunger.At the same time, he noted that small reports about violations of one page scale are less prioritized for Google.According to The Guardian, the accounts of the creators of the extortion virus received 42,000 from approximately 100 people.This time, the changes are even smaller than in the previous version of the document, which was published in May 2017.We publicly state that we have 200 factors when it comes to scanning, indexing and ranking.According to him, there are many affected companies, including large corporations.According to the ministry, only a few companies and individuals agreed to pay 300 to attackers, following the recommendations of law enforcement agencies.It should be recalled that the Google assessors guide has already been updated in March and May this year.We are an official UK stockist for all brands, and offer Free UK delivery (orders over.00 30 day returns and fantastic customer service.Instagram authorities believe that the innovation will strengthen the atmosphere of trust inside the service.Oct 08/2017, during the last video conference with webmasters Google rep called John Mueller said that Googlebot still refrains to scan http.
Bing and Yahoo both showed growth of up.4, while Google Maps was ranked up.2.
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The question was: key win 8.1 pro 64 bit vn zoom "When you mention Google's quality algorithm, how many algorithms do you use?".
Do you check each and every report manually?" The answer was: No, we do not check all spam reports manually.At the same time, the lowest indicator was in October, which is only.3.Typically, this type of attack is revenue-oriented.The section on using the Foreign Language label for pages in a foreign language like how many gold medals did gb win in 2012 olympics Ukrainian and Russian is replaced with an example of Catalan and Spanish.(Source: Content Marketing Institute) view also: Last Searches.I don't think that helding too many audits makes sense, because, as you noted, we successfully ignore the links, and if we see that the links are of an organic nature, it is highly unlikely that we will apply manual sanctions to a website.Since Google Penguin was modified into real-time update and started ignoring spam links instead of imposing sanctions on websites, this has led to a decrease of the value of auditing external links.Therefore, referential audits are needed if there were any violations in the history of the resource.As for the report processing time, it takes some considerable time.In the coming weeks, the new label will begin to appear in advertisements and bloggers stories all around the world.This information was reported by Jennifer Slagg in the Thesempost blog.
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Theodore Young
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Hi, I'm Theodore There's not much to say about me really, I'm just your average guy. I really want to go on a trip to Lima and have been planning a trip there next year. I'm in my first year at school. I enjoy everything outdoors and love hunting and fishing. I am pretty outgoing and love working with other people. I am interested in making new friends on here so don't be shy.
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Is there a cultural bias against such social-scientific findings compared with results that are seen to indicate genetic or biological causality? Despite Vaillant's emphasis on the uncontrollable nature of alcohol abuse, an illustration accompanying the Time magazine piece on Vaillant's book showed the Valliant family taking wine with a meal. Chrissy Teigen told Cosmopolitan in a story published in August that she was, "point blank, just drinking too much. Each day, participants were asked whether they had had oral sex 2 questions: Heroin addicts use many other drugs, and not only casually or in desperation. This strategy is highly unstable, however, because it depends mainly an the person's ability to remain outside drinking or drug-using groups throughout his or her lifetime. Find out what's happening in the world as it unfolds.
Nonetheless, the aim of "demoralizing" addiction retains a strong appeal for liberal observers and for social and behavioral scientists.
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The primary point of departure for Garn is evaluating whether "fatness" changes or remains constant throughout the individual's lifetime, based on Garn's own and several other large-scale longitudinal investigations. A keynote to the Reagan campaign as promoted by the First Lady has been the "Just Say No" program, whose aim is to have teenagers simply reject drugs whenever drugs are available. Journal of Personality and Social Psychology. Scales measured beliefs about Sexual Affect Alcohol Expectancies 6 items; e. Breaking the Diet Habit: The most emphatic rejection of the idea that people successfully achieve desired weight levels through planned eating strategies was presented by Polivy and Herman He understands that these recent actions are a symptom of a larger health problem and he has taken the first of many necessary steps towards recovery.


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ICAR- Directorate of Medicinal and Aromatic Plants Research Boriavi, Anand, Gujarat has arranged Walk-in-interview for the post of Project Assistant for the project titled "Standard Operating Protocols of Post Harvest Management for five selected Medicinal Plants". This engagement is purely on contract basis. Graduate students are eligible to apply for this post. Experienced candidates are also requested to apply for this post. Selected candidates have great opportunity to grab this chance and settle their career in this field. Selected candidates will be Rs.16000/- Per Month.
Who is eligible to apply for this post?
M.Sc. degree holders are eligible to apply for this post.
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Selected candidates will be paid Rs 16000/- per month
Deadline to apply for this post?
Interested candidates can attend walk in on 13th and 14th August 2018.
Name of the post: Project Assistant
No of Post: 2
Qualification: M.Sc. in Organic Chemistry/ Plant Sciences
Location: – Anand
Selection process: – Walk In Interview
How to apply: – Interested candidates can appear for Walk-in-interview at the following venue on 13th n 14th August 2018 along with all original documents
Venue of Interview- ICAR- Directorate of Medicinal and Aromatic Plants Research, Boriavi, Anand, Gujarat
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In a fluidic device with a storage compartment communication is allowed between the storage compartment and other portions of the device. The communication is controlled through a valve arrangement and a membrane covering the compartment. The valve arrangement can be provided through a sealing clamp with clamp fingers. The clamp fingers control communication between the storage compartment and remaining portions of the fluidic device.
This application claims priority to U.S. Provisional Application Ser. No. 60/852,936 filed on Oct. 18, 2006, entitled "Dot Matrix Style Pin Operated microfluidic Valve" Docket No. CIT-4751 and Serial Number No. 60/905,788 filed on Mar. 8, 2007 entitled "Microfluidic Biological Testing Device with Integrated Reagent Storage" Docket No. CIT-4855, the content of both of which is incorporated herein by reference in their entirety.
This invention has been made with U.S. Government support under Grant No. HG0026440 awarded by the National Institutes of Health. The U.S. Government has certain rights in this invention.
The present disclosure relates to the field of microfluidics and in particular to microfluidic devices and related methods and systems.
Microfluidic devices and systems are commonly used in the art for processing and/or analyzing of very small samples of fluids. In such microfluidic devices and systems, the integration of many elements in a single microfluidic device has enabled powerful and flexible analysis systems with applications ranging from cell sorting to protein synthesis. Some microfluidic operations that are functional to the performance of said applications include mixing, filtering, metering pumping reacting sensing heating and cooling of fluids in the microfluidic device.
Many different approaches have so far been explored for performing said operations in a microfluidic environment, including combining thousands of lithographically defined components, such as pumps and valves, into chip based systems to achieve control over reagents concentrations and reactions' performance.
According to a first aspect, a microfluidic device is disclosed, the microfluidic device comprising a storage compartment, a reaction area, a microfluidic channel, a valve arrangement and a membrane. In the microfluidic device, the storage compartment is adapted to comprise a reagent suitable for a reaction to occur in the microfluidic device, and the reaction area, is an area where a reaction involving said reagent is adapted to occur. In the microfluidic device, the microfluidic channel connects the storage compartment with the reaction area and the valve arrangement, to control opening and closing of the microfluidic channel. In the microfluidic channel, the membrane adapted to cover at least portion of the storage compartment, reaction area, and microfluidic channel, the membrane being also adapted to seal the at least portion of storage compartment, reaction area, and microfluidic channels, in particular upon filling of the storage compartment with the reagent.
According to a second aspect, a hermetically sealed bag is disclosed, the sealing bag comprising the microfluidic device described above.
According to a third aspect, a machine reader is disclosed, the machine reader comprising the microfluidic device described above.
The details of one or more embodiments of the invention are set forth in the accompanying drawings and the description below. Other features, objects, and advantages will be apparent from the description and drawings, and from the claims.
The accompanying drawings, which are incorporated into and constitute a part of this specification, illustrate one or more embodiments of the present disclosure and, together with the detailed description, serve to explain the principles and implementations of the complexes, systems and methods herein disclosed.
In the drawings:
Like reference symbols in the various drawings indicate like elements.
A microfluidic device is herein disclosed that is adapted to include a storage compartment comprising a reagent suitable for a reaction to be performed in the microfluidic device.
In particular, in some embodiments, a sample preparation chip is disclosed that can be stored, e.g. at room temperature, for a predetermined period of time, and especially for long periods of time, while storing all necessary reagents to operate the chip in a determined state. The storage state of the reagent is compatible with a desired temperature of storage (e.g. lyophilized for room temperature storage). In some embodiments, the temperature of storage is from 4° C. to room temperature.
When use of the chip is desired, the reagent might need to be brought to a state where they can be used in a reaction mixture. For example, in embodiments wherein a reagent is lyophilized, the reagent can be contacted with a liquid, such as water, to be reconstituted. In some of those embodiments, the reagents in lyophilized form and the liquid can be stored in separate compartments of the same chip or device. In particular, in some embodiments, at least two storage compartments are provided in the chip and connected to each other by way of a valve regulated channel. When storage of the substances stored is desired, the valve is closed and no communication occurs between the two compartments. When use of the chip is desired, the valve is opened, thus putting the two storage compartments in communication thus allowing reconstitution of the reagent(s) stored therein.
In some embodiments, the storage compartment is covered by a deformable membrane, such as a SIFEL membrane, that can be operated in combination with a valve arrangement reversibly closing the channel connecting the storage compartments by pinching the deformable membrane. In those embodiments, the use of a material to cover the compartment that is different from the material of the compartment, allows to obtain chemically robust storage compartments able to hold all sort of solvents, including ethanol, and to be operated with a valve system that allows the solvents to be released in other compartments of the chip, when desired.
In some embodiments, the membrane made of deformable material covers also additional non-storage compartments and/or microchannels, and the valve arrangement used to release the reagents from the storage compartments can advantageously be one of the valve arrangements previously described.
In some embodiments, the chip including the storage compartment herein described can be manufactured by 1) providing a base layer, 2) providing cavities in the base layer that will form channel(s) and compartment(s) of the microfluidic chip; 3) filling at least one of the cavities with a substance of interest; and 4) providing a membrane of deformable material to cover the cavities. In particular, the deformable membrane can be contacted with the base layer to seal the cavities. In some embodiment, the microfluidic device includes one storage compartment connected to a reaction area by a channel. In some embodiments the microfluidic device includes two or more storage compartments connected to a reaction area and to each other by a channel.
In the exemplary illustration of
The reaction area (97) is connected to a sample port including a filter (96) e.g. a Pall® or Whatman® blood filters) and to a waste area (98). The waste area (98) is connected to a vent (99). In operation, vacuum can be applied to the vent (99), possibly through a vapor barrier filter embedded in the channel, or otherwise attached or sealed to the chip and the vacuum in combination with the dot matrix style pin operated valves (not shown) controls the flow of fluids in channels (932) and (95) from the compartments (91) and (92). Mixers (94) can be located along the channels (932) to mix the substance of interest released from the liquid storage compartment (91) and the dry storage compartment (92), thus improving homogeneity of the reagents constituted. Several types of mixers can be used that are identifiable by a skilled person and will not be described herein in further detail.
In the embodiment of
In some embodiments, illustrated in
In some embodiments, illustrated in
In those embodiments, the bottom of the chip or card (900) can be an injection molded plastic card with the channels defined in it. The top section of the card can be a polymer which is molded in a thin layer and adheres to the plastic without blocking the channels as discussed previously in more detail. Suitable polymers include but are not limited to several versions of SIFEL and any other polymer that is impermeable to liquid and gas (preserving the reagents inside) and possibly flexible enough to act as a valve membrane if actuated by a pin or plunger as previously described (see, e.g.,
In the embodiments exemplified by
In some embodiments, illustrated by the exploded sectional view of
In operation, the valve clamps (960) and (970) are operated to allow communication between compartments (91) and (92). When desired, vacuum and the dot matrix pin operated valve can direct the flow of fluid from the compartments (91) and (92) to reaction chamber (97), see previously described
The clamp (950) illustrated in the exploded sectional view of
In some embodiments, the chip, device or card (900) is also meant to be used in a machine reader or controlling unit such as the controlling unit (2) illustrated in more detail later in this disclosure (see
In some embodiments, the thin membrane can be used as a pump by just pushing on it with mechanical means to push fluid. The thin membrane can also be actuated electromechanically as described herein. In some embodiments, a plurality of pump valves (e.g. 3 pump valves) can be actuated in connection with the thin membrane as a peristaltic pump.
In some embodiments, the vacuum inlet (99) already shown with reference to previously described
In some embodiments, where the waste compartment (98) and/or the channels connecting the waste compartment (98) with the outside of the chip (900) are also covered with a layer of deformable material, the waste can also be stored on the card, and in particular locked in place by the clamp valves such as previously described valve clamp (950) at the time the card is removed, thus making it safe to dispose of the card.
The valve clamp (950) and associated valves or fingers (960, 970) will be described in greater detail in the following illustrations of
In the top view of
In the illustration of
In some embodiments the microfluidic device can be operated in a microfluidic assembly herein described, wherein a microfluidic valve arrangement is provided. The microfluidic valve arrangement allows control of the flow in one or more microfluidic channels of the microfluidic assembly.
In particular, in some embodiments, the microfluidic valve arrangement is comprised of an electromagnetic solenoid actuator and of a thin membrane, wherein the solenoid actuator is used to actuate the microfluidic valve through direct compression of the thin membrane as illustrated further in the exemplary embodiments of
In the exemplary embodiment shown in
In the microfluidic assembly (400) illustrated in
In particular, each valve includes a tiny metal rod, wire or pin (48). Rod (48) is driven forward by the electromagnetic power of the solenoid, either directly or through small levers. Specifically, upon input from the control unit, current goes through the solenoid (45) and the pin (48) moves up and down by way of induced magnetic forces while the solenoid (45) stays in position
In particular, when in operation, pin (48) is pushed down along the direction of the arrow A1 to deform portion (46) of the chip (41) and close channel (42), thus blocking flow passage inside the channel (42). The material of the membrane (46) and the shape and configuration of channel (42) are selected to be deformable and ensure closure of the channel (42).
In some embodiments, the microfluidic chip (41) can be a thin fluidic chip 10-100 micron tall. The channel (42) and substrate (43) can have variable dimensions. In particular, the dimensions and shape of channel (42) are functional to the desired valve effect and can vary in view of the material forming the channel and additional parameters such as thickness of the thin membrane (46) and material forming the thin membrane.
The thickness of the thin membrane (46) can be selected in view of the shape and dimensions of the channel (42) and the force exerted by the solenoid (45) on such membrane, so that the force of the solenoid is sufficient to depress the thin membrane (46) and deform it to the extent of closing the channel (42) without piercing the membrane or affecting the ability of the membrane (46) to seal the channel.
Preferably, the dimensions of the channel (42) and the thickness of the membrane (46) are controllable, to obtain a balance that allows to reversibly close the channel, by use of the spring constant of the deformable material of choice.
In addition to membrane thickness, channel shape and ability of the material forming the thin membrane to provide a spring effect, additional properties of the material forming the thin membrane, such as robustness, can be taken into account to ensure proper functioning of the membrane while preventing the solenoid from piercing the membrane, considering thickness and shape of pin (48). In some embodiments the shape of the channel is rounded an in particular the shape of the bottom of the channel is rounded so that at least portion of the surface match a corresponding rounded surface on the lower portion of the pin.
In some embodiments, the channel (42) is a microchannel with a width ranging from about 2 microns to about 1000 microns, usually about 200 microns selected to closely match the dimensions of the solenoid (45). The height of the channel can be (usually ranging from about 2 microns to about 300 microns) to allow proper fitting of the one into the other. As to the other dimensions of the channel, such as depth and height, dimensioning will depend on the ability of the solenoid (45) to depress the thin membrane (46) and can be from about a quarter of millimeter to about a millimeter.
The above dimensions correspond to standard measures that can be desirable when the use of standard component is desired. However, the valve arrangement of the present disclosure can also be manufactured with customized parts and dimensions as long as proper interaction of the different parts are maintained.
The valve arrangement illustrated in
In the embodiments exemplified in
In some embodiments, a reinforcing layer or thick layer (44) can be included in the microfluidic assembly (400). The reinforcing layer (44) comprises holes into it to allow the solenoid pin (45) to pass through. The thick layer (44) can be aligned to the top and held in place, either through chemical bonding or by physical means. Although
In the assembly herein disclosed, the orientation of the thin membrane (46) within the microfluidic chip does not affect the operation of the valve arrangement within the chip. Therefore, in some embodiments the thin membrane can be located on the upper side of the channel (as shown in
In particular, in some embodiments, exemplified by the schematic illustration of
In the valve arrangement of
In both of the embodiments illustrated in
In particular, in the embodiments exemplified in
Accordingly, while in some embodiments, exemplified by
Additionally, in the embodiments, exemplified by the schematic illustration of
In particular, in some of the embodiments exemplified in
In embodiments wherein the thin membrane (57) and the channels (52) are formed of a same material (similarly to the embodiments of
In some embodiments, the thin membrane (57) of the embodiment of
In some embodiments, the thin membrane (57) is bonded to the chip (51) by first providing a film of deformable material, and then contacting the film with the chip (51) to cover the channel/compartments formed therein. The film of deformable material is then cured to bond with the chip (51). In these embodiments, the channels and/or compartments of the microfluidic chip are formed after adhesion of the membrane to the microfluidic chip.
In some embodiments, providing a film of deformable material is performed by contacting the deformable material with a flat surface, preferably made of a material with a minimized ability to adhere to the deformable material, and spinning the deformable material on the flat surface to provide the film of the deformable material. In particular, the spinning operation creates a membrane of a certain thickness functional to the spinning speed and the nature of the material used.
Particularly suitable materials for forming the thin membrane (57) are deformable materials, such as SIFEL or PDMS, capable of bonding with a rigid material of choice forming the channel/compartments of the chip (51) such as polypropylene or polystyrene.
Curing of the deformable material can be performed by several methods known in the art including but not limited to UV irradiation, heat, chemical treatment and additional methods identifiable by a skilled person.
In some embodiments, contacting the film of deformable material is performed by placing the chip over the film, to minimize drooling of the deformable material on to the channel.
In some embodiments, contacting the film of deformable material with the chip can be performed on a surface made of a material that has a minimized ability to adhere to the deformable material, e.g. Teflon, when the deformable material is SIFEL.
In some embodiments, the film of deformable material is formed by tensioned sheets and contacting the film of deformable material with the chip can be performed to maintain tension of the tensioned sheet and possibly using an adhesive to seal the film on the chip.
As already noted above, in some embodiments, the chip (51) can further include a mechanical clamp (56) to also hold the thin membrane (57) and the chip (51) in place over a base plate (54) with holes drilled at appropriate places to allow the solenoid (55) to pass through, similarly to what discussed with reference to the embodiment of
In some embodiments of the dot matrix valve, the pin mates with a hole in the microfluidic chip (in-chip configuration), or in a hose that has been inserted into the chip (off-chip configuration), as shown in
In particular, in some embodiments, exemplified in
In those embodiments, two layers can be bonded or held together with a clamp, one layer comprising channels defined as the "control channels" (68) and (78) and the other with channels defined as the "flow channels" (62) and (72). The control fluid (89) will be located in the control channel (68) and (78) and will push on a membrane (67) and (77) separating the control channels (68) and (78) from the flow channels (62) and (72).
In some embodiments, the control fluid (89) is provided to a chip (81) within a hose (83) (see in particular
In the embodiments described in the exemplary schematic illustrations of
In some embodiments, movement of the solenoid towards the control channel creates a vacuum in the control channel and therefore a negative pressure on the control fluid and through the control fluid on the thin membrane. In some of those embodiments, such negative pressure is exerted to perform a fluid handling task. For example, a task that requires a small vacuum such as dislocation of a small amount of fluid backward in the fluid channel can be performed, to possibly perform a test or allow a predetermined reaction.
In some embodiments, the thin membrane is located on the upper side of the flow channels to be controlled, and the corresponding valve arrangement is a push-down valve (see
In some embodiments, the valve arrangement is operated in combination with Quake-style valves, such as the ones described in U.S. Pat. Nos. 6,408,878, 6,793,753, 6,899,137, 6,929,030, 7,040,338, 7,144,616, 7,169,314, 7,216,671, all of which are herein incorporated by reference in their entirety.
An exemplary microfluidic chip where the valve arrangement herein described can be operated in combination with a Quake-style valve is the chip described in US Published Patent Application US2006/0263818 to Kartalov et al, also incorporated by reference in its entirety in the present application. Such chip or device will be hereinafter indicated as "Kartalov chip."
The Kartalov chip includes a first layer (see flow layer 32 in FIG. 1 of US2006/0263818) for liquid flows and a second layer wherein another fluid or air could flow (see control layer 36 in FIG. 1 of US2006/0263818). By making the first layer very thin and the second layer very thick, pressurization of the second layer communicates the pressure from the second layer to the first layer to force the first layer into closing the channel. In the Kartalov chip, the pressure is created by a pressurized gas system controlled by micromechanical valves. On the other hand, the present disclosure deals with a pin/membrane combination, that can replace the external source of pressurized gas and the external manifold including valves to control feeding of the gas inside the pressurized gas inside the chip.
In some embodiments of the valve arrangements according to any one of the configurations exemplified by the illustration of
In some embodiments, the solenoid actuator and microfluidics can be located on separate components, with the microfluidic component disposable while the solenoid component is a multi-use component, connected and possibly including a controlling unit. In some of those embodiments, the microfluidic portion can be replaced for sterility or other reasons while the solenoid arrangement and the controlling unit is maintained for multiple uses.
In some embodiments, an array of dot matrix style pin operated microfluidic valves can be used to control the flow of fluid in fluid channels and through the channels in the compartments. In particular, in some of those embodiments, a plurality of valves is operated along a channel to create a peristaltic movement of the thin membrane and corresponding fluid flow inside the channel.
In particular, in some embodiments, an array of such valve arrangements can be created, with a controlling unit holding each solenoid pin in place, either on a hinge or some other mounting method. A disposable microfluidic chip is placed in the correct orientation. More in particular, in some embodiments, the array of solenoid pins is lowered into position (or the chip raised) and the chip can be actuated with the solenoid pins.
In some embodiments, the solenoid actuator (45, 55) and the chip (41, 51) are included in separate components of the fluidic circuit (400, 500). More particularly, the solenoid actuator (45, 55) is included in a multiuse controlling unit, while the microfluidic chip (41, 51) is a disposable mono-use microfluidic chip. In particular, in some embodiments, a box or holder can be provided, into which a disposable microfluidic chip can later be placed. The box contains everything needed to carry out the experiment except for the fluidics portion (the microfluidic chip). In this kind of arrangement, the fluidics portion can be disposable.
Reference is made to
In the schematic illustration of
In some embodiments, the holder (19) also includes a controlling unit, the controlling unit operating the solenoid valve arrangement. In particular, in some of embodiments, the controlling unit is non-disposable or multiuse unit, while the microfluidics is disposable, i.e. single-use.
In both embodiments, the solenoids are usually arranged so to be used in combination with a chip of choice, typically a standard chip, to match predetermined positions on the chip so that when in use the solenoids can operate on those specific positions as desired, e.g. by using an appropriate software. In some embodiments, the solenoid arrangement in the unit is modified after the use but usually a specific arrangement is used multiple times on the same kind of chip, so that one control unit typically corresponds to one type of chip.
In some embodiments, the valve arrangement is the one exemplified in
In some embodiments, the microfluidic valve or pump can be electrically actuated. In some embodiments of the valve arrangement herein included, the solenoids can be replaced by pins coming down and closing the channels, although in some embodiments a solenoid could be preferred because it can be controlled electrically. Additional arrangements can be operated by other electrical or non electrical means such as pressurized fluid (e.g. air) or a thermostatic operator (e.g. a bimetal coil).
In some embodiments, the valve arrangement or valve arrangement array is actuated by sending an electrical signal to the solenoid, pushing out the pin onto the membrane, causing the channel to pinch off as it pushes against the substrate.
In particular, in some embodiments, illustrated in
In particular, in some embodiments, illustrated in inset D of
In some embodiments, collection of a sample (e.g. blood urine, saliva, semen, feces, water, food, breastmilk, vaginal secretions, tears, earwax, mucous etc.) is performed and the sample and then processed through appropriate sample preparation steps before introduction into the microfluidic assembly (400) or (500). In the microfluidic assembly, the sample will then be transferred in flow channels by the valve arrangement actuated by the solenoid actuator (pin valves) herein disclosed. In some embodiments, the system includes also a signaling element providing input to a detector in the controlling indicating the location of the sample in the microfluidic assembly.
It is to be understood that the present disclosure is not limited to particular arrangements devices and methods, which can, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting. As used in this specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the content clearly dictates otherwise. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the disclosure pertains. Although any methods and materials similar or equivalent to those described herein can be used in the practice for testing of the disclosure(s), specific examples of appropriate materials and methods are described herein.
The examples set forth above are provided to give those of ordinary skill in the art a complete and description of how to make and use the embodiments of the arrangements, devices, systems and methods herein disclosed, and are not intended to limit the scope of what the applicants regard as their disclosure. Modifications of the above-described modes for carrying out the disclosure that are obvious to persons of skill in the art are intended to be within the scope of the following claims. All patents and publications mentioned in the specification are indicative of the levels of skill of those skilled in the art to which the disclosure pertains. All references cited in this application are incorporated by reference to the same extent as if each reference had been incorporated by reference in its entirety individually.
A number of embodiments of the disclosure have been described. Nevertheless, it will be understood that various modifications may be made without departing from the spirit and scope of the disclosure. Accordingly, other embodiments are within the scope of the following claims.
1. A microfluidic device comprising
- a storage compartment, the storage compartment adapted to comprise a reagent suitable for a reaction to occur in the microfluidic device,
- a reaction area, where a reaction involving said reagent is adapted to occur;
- a microfluidic channel connecting the storage compartment with the reaction area;
- a valve arrangement, to control opening and closing of the microfluidic channel; and
- a membrane adapted to cover at least portion of the storage compartment, reaction area, and microfluidic channel, the membrane being adapted to seal the at least portion of storage compartment, reaction area, and microfluidic channels, upon filling of the storage compartment with the reagent.
2. The microfluidic device of claim 1, wherein the storage compartment includes a first storage compartment and a second storage compartment and the microfluidic channel connects the first storage compartment with the second storage compartment
3. The microfluidic device of claim 1, wherein storage state of the reagent is compatible with a desired temperature of storage.
4. The microfluidic device of claim 3, wherein said temperature of storage is from 4° C. to room temperature.
5. The microfluidic device of claim 1, wherein the reagents are in a first physical state during a rest state of the microfluidic device and are brought to a second physical state during an operative state of the microfluidic device.
6. The microfluidic device of claim 1, wherein the valve arrangement comprises a solenoid actuator and a membrane, and wherein movement of the solenoid actuator is adapted to deform the membrane thus preventing flow in the microfluidic channels.
7. The microfluidic device of claim 1, further comprising a waste area connected to a vent, wherein, during operation of the microfluidic device, vacuum is adapted to be applied to the vent to control flow in the microfluidic channels in combination with the valve arrangement.
8. The microfluidic device of claim 1, further comprising a microfluidic mixer located along the microfluidic channel.
9. A hermetically sealed bag comprising the microfluidic device of claim 1.
10. A machine reader comprising the microfluidic device of claim 1.
11. The machine reader of claim 10, the machine reader further comprising clamp valves actuated by said machine reader.
12. The microfluidic device of claim 1, further comprising a top cover, the top cover allowing initial storage of liquid and dry substances in the liquid storage compartments and the dry storage compartments.
13. The microfluidic device of claim 1, comprising a top section and a bottom section, the top section being a polymer molded in a layer and the bottom section being a plastic card containing the storage compartments, the reaction area and the microfluidic channels.
14. The microfluidic device of claim 1, the microfluidic device further comprising a clamp to allow connection of the microfluidic device to a substrate.
15. The microfluidic device of claim 14, wherein the clamp is a metal or plastic clamp.
16. The microfluidic device of claim 1, further comprising a cover element including valve clamps, the valve clamps acting as the valve arrangement.
17. The microfluidic device of claim 16, wherein the valve clamps are electromechanically actuated.
18. The microfluidic device of claim 16, wherein the valve clamps are bendable valve clamps.
19. The microfluidic device of claim 1, further comprising a sealing clamp, the sealing clamp adapted to seal the membrane at least over the storage chambers.
20. The microfluidic device of claim 19, wherein the sealing clamp comprises at least one clamp finger, the at least one clamp finger being part of a valve arrangement and adapted to provide a valve control communication between the first storage compartment and the second storage compartment.
21. The microfluidic device of claim 19, wherein the at least one clamp finger and the sealing clamp are independently operable.
22. The microfluidic device of claim 19, further comprising at least one clamp lever to actuate the at least one clamp finger.
23. The microfluidic device of claim 19, wherein the at least one clamp fingers are a plurality of independently operable clamp fingers.
24. The microfluidic device of claim 19, wherein the clamp fingers are adapted to seal other portion of the microfluidic device to prevent the fluid from coming out of the microfluidic device after use.
25. The microfluidic device of claim 1, further including a filter trapped in a microfluidic channel.
Patent History
Type: Application
Filed: Oct 18, 2007
Publication Date: Jun 19, 2008
Patent Grant number: 7790118
Inventors: George Maltezos (Fort Salonga, NY), Axel Scherer (Laguna Beach, CA)
Application Number: 11/874,213
International Classification: B01J 19/00 (20060101);


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Teaching and tutoring English as a second language is a great way to make money online, not to mention open some doors for you to travel the world if you'd like. While full ESL (English as a Second Language) accreditation is recommended, as long as you're a native speaker and have the ability to teach, there are people in countries such as Hong Kong or the UAE who are willing to pay upwards of $25/hr for you to tutor them English via Skype. Check out Indeed, Learn4Good and Remote.co for remote english tutoring jobs or sign up on a specialized site like VerbalPlanet or Chegg Tutors.
What a huge, great list of ideas – bookmarked this as I know I'll be coming back to go over it again and again. Here's another item that could have made the list. I found a financial directory that's useful for info on making money online. It's http://money.madbeetech.com. What I like about it is that each directory listing includes ebooks and videos that can be instantly downloaded. All sorts of stuff for people who have their own website, and people who don't (but still want to make money online).
It doesn't pay much, but if you're a healthy person and want to make a bit of extra money online, the AchieveMint app will reward you for doing things like walking, tracking your food, or taking health surveys. AchieveMint works by connecting to fitness apps you might already be using like Fitbit, RunKeeper, Healthkit, and MyFitnessPal and then giving you points for certain actions. For every 10,000 points, you earn $10 with no limit on your earnings.
The grant ran for 12 months and I was under the assumption (incorrectly) that I had to show consistent income growth in order to maintain my qualification for the program. My income at the time always suffered a downturn around Christmas/Summer in Australia. To combat this problem I decided to teach English face-to-face with people in Brisbane to hopefully boost my reportable income.
Please note: This is an expensive form of credit and is intended only for short-term financial needs. Spotloans are designed to help you deal with emergencies such as rent, medical bills, car repairs, or expenses related to your job. Spotloans are not intended to solve longer-term credit or other financial needs, and alternative forms of credit may be better for you, including borrowing from a friend or relative; using a credit card cash advance; taking out a personal loan; or using a home equity loan or savings. Contact one of our relationship managers to discuss if a Spotloan is right for you.
I make good money thieving. I only work a few hours a night, and you can make anything from a few hundred quid to a few thousand quid. You've got to have a bit of bottle and be able to look after yourself. If you think you've got thr guts to do it? I highly recommend it, I mean it's got to be better that spending hour after hour on a PC, making small chance, how boring is that?
Once you have decided what type of product you are going to sell, you need to decide where to sell them. Selling merchandise on Amazon or eBay aren't your only options. Creating your own eCommerce store is another way to promote your products and generate sales. Once you have decided what you are going to sell, whether it is white labeled products, your own designs, or other people's merchandise, you can set up an eCommerce website to display these products.
Writing an eBook and selling it on your blog can be a great money maker. Your eBook should be directly relevant to your blog's content so you can sell your book to your existing audience. Creating a recipe eBook for a food blog or an eBook full of training plans to complement your fitness site are just a couple of examples that have the potential to sell.
Rent out a parking spot. If you live in a busy or congested area and have parking to spare, you might be able to rent out your parking space for some quick cash when you're not using it. Simply advertise your open parking space online including details on the location, whether it's covered or uncovered, and your desired hourly, weekly, or monthly fee. If you want, you can even use a site like Just Park or download the Spot App to reach more potential customers.
Hey!, I'm just putting some feelers out there to see if there's anyone interested in making a pretty substantial amount of cash in a short amount of time. Only thing this requires is that you have an active bank account or credit card in the US. No cash is required up front to start. Which means your account can be on a zero balance and that's completely fine. There are different money deals that suit just what you want, contact firstname.lastname@example.com
If you are not tech savvy you cannot earn anything online and let no one tell you that you can just setup a blog or niche site have money streaming in. The dynamics of getting traffic to your site is very complicated. I have been a web developer for over 12 years now but I can assure you that the road is not smooth. The learning curve is the longest than earning PHD.
CashCrate sends out literally thousands of payments a month to users just like you who spend time completing surveys and offers on CashCrate.com. How do they do it? Well, they do surveys and offers regularly. It really adds up! Your initial goal should be to meet minimum payout, which is $20.00. Making $20.00 in free cash is actually quite easy considering there are hundreds of surveys and offers available, but here are a few tips to get you to your goal faster:
Create a writer website or blog. A website not only demonstrates your technical ability, but it also creates an online hub that allows clients to connect to you. Keep the design of your website clean and uncluttered. Include examples of your work that demonstrate the kind of writing you do. Make the samples easy to find and to read, and make it easy for visitors to figure out how to contact you.[23] .
If you've got some free time and don't live in the middle of nowhere, becoming a Lyft driver can be a very lucrative side hustle that allows you make money fast. And right now, they've got a promotion going on where any new driver will instantly get a $300 bonus after completing their 100th ride. If you start now and hustle hard on the weekends, you can probably unlock that bonus within a few weeks of driving (and that's in addition to your normal earnings).
There are many freelance options for graphic designers who are looking to make money online. Designing layouts and graphics for promotional material, corporate reports, magazines or book covers, are all tasks that businesses are looking for online freelancers to complete. Due to its flexible nature, graphic design possibilities can range from one-off projects to ongoing work with regular clients.
Open an Etsy store. If you have a creative talent or skill – whether it's creating art, sewing clothes, or making keepsakes – you can open an online store on Etsy.com and sell your wares for some quick cash. With your own Etsy store, you're left in charge of pricing and, ultimately, how much you make. See our detailed primer, "How to Make Money on Etsy."
Enjoy making silly videos? Even short, silly videos can sell products online. Find an product worth promoting that has an affiliate program, then target your video toward potential customers of that product. In your video summary on YouTube, place your affiliate link for the product, and after the video, do a 30-second still frame showing a short URL where people can buy the product. If your video is funny, informative, or useful, you may sell some products. Big tip: Try to promote a product that makes you a fair amount of money for each sale, but doesn't cost a whole lot for the potential customer. You can find products on Commission Junction, for one.
Take it seriously. Yes, you're applying for an online job. Yes, you can do the work in your underwear, but that doesn't mean it's not a "real job". You must treat it as such or they aren't going to treat you as a serious candidate. You aren't the only one who wants to work in their underwear. In fact, the competition online is likely higher than it is in your local area.
Once you have that problem or need nailed, the next step is to validate that idea and make sure you've actually got customers who will pay for it. This means building a minimum viable product, getting objective feedback from real customers, incorporating updates, testing the market for demand, and getting pricing feedback to ensure there's enough of a margin between your costs and what consumers are willing to pay.
Consider your expertise. If you take the time to reflect on your experiences, you will realize that you have more knowledge about which to write than you might think. Begin by listing three assets that define you, such as your profession, a special hobby or a personality trait. Next, list three things that inspire you, such as religion, education or charity. Finally, list three of your dreams, such as getting married, traveling or spending more time with your children. These three lists should give you many ideas of topics about which you can write.[13]
Start a bed and breakfast. If you live in a popular resort area or own a historic property, a B&B might be the perfect side hustle. Not only can you work at home with this career, but you'll also score some tax write-offs in the process — although most innkeepers caution that the profession requires a lot of hard work and is more of an attractive lifestyle than a money-making pursuit.
Initially I didn't mind writing paid reviews as the income was pretty good in terms of how long it would take and how much I earned. I could make as much as $250 an hour, which was great at first, but as my motivation focused more on freedom and less on money, even this became a poor incentive. Plus I never did like that I was told what to write about rather than choosing subjects I enjoyed.
Not very exciting work, but in high demand from bloggers and small businesses. This involves setting up accounts on all of the social bookmarking services and then bookmarking your clients' websites or latest blog posts to help them get more traffic. You may be competing against software that does this, but in many folks' opinions, it's better to have a real person do it. Even better is if you can goose your accounts with plenty of friends and become a star on a few of the services; then every site you bookmark has higher credibility and you can charge more. To get an idea of the social media sites you will need to sign up for, start at socialmarker.com.
Not quite ready to start your own blog, but still like the idea of getting paid to write? You may want to consider trying your hand at freelance writing. Many bloggers and website owners are willing to shell out some serious cash for high quality writers. In fact, Holly Johnson from ClubThrifty.com makes over $200,000 per year from freelance work! And she has a course that teaches others how to do the same.
I have had many tribal loans from many different tribal lenders. Many of them are little more than professional loan sharks. Spotloan gives you a clear payment schedule with a clear payoff date upfront. They don't want you to wallow in a permanent mire of never-ending interest. They want to help you with a short-term solution, not a long-term trap. Absolutely one of the BEST lenders I have ever worked with, including mainstream lenders! Highly recommended!
Build your audience on a course community: If you're just getting started building an audience for yourself and want to leverage communities already actively looking for content you can choose to host and sell your online course on a site like Skillshare or Udemy. These are easy, cost-effective ways to build an audience and test your niche to see if there's demand for it.
Competition is stiff, but if you are a savvy designer, this is a good way to pick up extra dollars. Even better, if you are an artist, this is a good way to make your art skills pay off. Consider that every design will need to have a reason why the customer should buy the book or follow that person on Twitter to have a real impact. Twitter backgrounds, in particular, are in hot demand right now. For measurements and caveats of Twitter backgrounds, read "How to create your own Twitter background."
Today, if you're at all serious about succeeding in any endeavor, whether online or offline, you have to deliver enormous amounts of value. Yes, you have to do the most amount of work for the least initial return. This is especially true online. Why? Because it takes time to build authority and create an audience, two primary ingredients necessary to succeed in the wonderful world of commerce on the web.
CashCrate sends out literally thousands of payments a month to users just like you who spend time completing surveys and offers on CashCrate.com. How do they do it? Well, they do surveys and offers regularly. It really adds up! Your initial goal should be to meet minimum payout, which is $20.00. Making $20.00 in free cash is actually quite easy considering there are hundreds of surveys and offers available, but here are a few tips to get you to your goal faster:
A niche affiliate site often presents like an eCommerce store. To get started with an affiliate site, choose your niche then display products with pictures, descriptions, and prices, just as you would on an online store. However, when visitors click the 'buy' button, they will be taken directly to Amazon, to make the purchase. You then make an affiliate fee for sending the traffic to Amazon but have none of the packaging hassle, or initial financial output creating or buying the products.
To test these websites, you'll be asked to visit the site in question and record your reactions and thoughts as you go through it. To get started making extra money online by testing websites, sign up for some of the most popular services like UserTesting.com, Userlytics, TryMyUI, Userfeel, TestingTime (for people outside the U.S), or Side Income Jobs.
Keep in mind though, you don't need a website to do sponsored content since you can also get paid if you have a lot of social media followers. My wife has a pretty big Instagram following, and she gets all kinds of sponsorships. Not only does she get paid in cash, but we get a lot of free stuff, too. We've received free rugs, free lights, and free carpet cleaners. She only promotes things she loves though, so this strategy works really well for her.
5. Fiverr – Fiverr is a great place to make a few bucks or spend a few bucks if you need some of the services people offer. Basically, everything is $5. You either pay $5 or charge $5. They call them "gigs." You can offer your services however you choose. If you sell art and you're fine selling pieces for $5 each, that's a gig. If you're a graphic designer and you want to offer your services for $10/hour, simply offer a 30 minute gig. If they need two hours of graphic design, they pay you $20, or $10/hour by buying four gigs.
Fancy yourself a good designer? Try your hand at creating a logo or other design that a company loves! 99 Designs is the most popular marketplace. Beware, however; you won't get paid unless your logo wins against many others, which makes many designers unhappy. In my opinion, this is a great way for a budding designer to build a portfolio and learn quickly what clients love.
I'm a huge fan of blogging because I love writing and connecting with people all over the world. To give you an idea of what is possible with blogging, DollarSprout.com is part of a group of blogs that routinely brings in over $100,000 a month in revenue. While it takes time to build your blog up to that income level, you can get the initial set up done in under 30 minutes (no experience needed).
Do you love getting refunds? How cool would it be to get money back on stuff you've already bought? Paribus is a service that lets you find out if stores you've shopped at online owe you a refund. It's free to sign up. Paribus connects to your email account and checks your receipts. If they find out a retailer has dropped their price they file a price adjustment claim for you. Try out Paribus.
If you love to travel and find yourself randomly searching for airfare sales or browsing Lonely Planet, why not carve out a niche for yourself as a private travel agent? My friend, Mark Jackson did just that, making extra money online with his travel consulting side business. Start with word of mouth recommendations from friends who know they can count on you for the cheapest flights, and then move on and create a Facebook or LinkedIn group to invite people who want to stay on top of the latest deals. Eventually you could spin this into a full-time consultancy teaching people how to make their dream trip a reality.
Now, I know what you're thinking. Most of the software and apps you use on a regular basis are made by massive companies or established development studios. Well, yes. But many successful apps, particularly those in the Apple and Google stores, are created and marketed by individuals and small businesses. In fact, independent developers made $20 billion in the App Store in 2016 alone.
Monetize a hobby. While some hobbies actually cost money, others can be transformed into a profitable business venture. Ultimately, it depends on what your hobby is and how talented you are. You could turn your love of photography, for example, into a part-time gig taking family portraits and wedding photos or selling prints on Etsy or at arts fairs.
Writing an eBook and selling it on your blog can be a great money maker. Your eBook should be directly relevant to your blog's content so you can sell your book to your existing audience. Creating a recipe eBook for a food blog or an eBook full of training plans to complement your fitness site are just a couple of examples that have the potential to sell.
Alibaba is a Chinese eCommerce store that matches Chinese suppliers with buyers all over the world. Prices are extremely cheap, providing the possibility of large profits. However, with the potential profits comes more risk. As you are dealing with suppliers in China, if the quality of the product that arrives isn't up to standard there is little that you can do about it.
Mechanical Turk is a great way to make some extra cash. You probably won't make much more than a few dollars an hour, but it's also dead simple to complete many of the tasks. Most tasks take less than a minute to complete and pay a few pennies. If you do a lot of MTurk, it could add up to at least some fun spending money. Sign up for free, then complete qualifications to earn access to higher-paying tasks.
If you live in an area where Uber or Lyft operate, why not become a driver? If you're looking to make some short-term cash, you can definitely rake it in by working for one of these popular car-hire apps. As long as your vehicle fits within the specifications of their program, and you have a clean license, you could do this on the side, especially if you're in a crunch for cash.
Thanks for the great post. I couldn't agree the more with you that a lot of times people end up having to spend more time to struggle with their online business rather having quality time with their family and etc. I think you hit the nail when you mentioned that one of your goals is to ensure you adopt an approach and system that allows you to not getting stuck in the trade hour for money kind of thing.
Similar to a YouTube vlogger, if you have a large following on Instagram then you could become an Instagram Influencer. You will be paid to promote products in your photos, from wearing certain clothes to action shots of you using particular merchandise. As your Instagram following grows, you may start out simply receiving freebies in return for a picture of you with the item in the shot. However, for those with followings running into millions, you can expect large payments to display products in your pictures. Use sites like Hype Factory to help connect you with companies prepared to pay for your influence.
Online savings accounts usually come with crazy good interest rates to help you grow your money faster (regular in-person banks can't offer rates as high). We're fans of CIT Bank and Discover Bank (among others) because their interest rates are often over 25 times the national average. That means the money in your savings account will grow 25 times faster than the pace it's most likely growing at now. Really, though, you can't go wrong with pretty much any online savings account that offers over 1.50% APY 🙂