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That's me, according to the Myers-Briggs personality profile, based on Jungian typology. You can find a description of the INTJ type here. Here's some of what it says:
To outsiders, INTJs may appear to project an aura of "definiteness", of self-confidence. This self-confidence, sometimes mistaken for simple arrogance by the less decisive, is actually of a very specific rather than a general nature; its source lies in the specialized knowledge systems that most INTJs start building at an early age. When it comes to their own areas of expertise -- and INTJs can have several -- they will be able to tell you almost immediately whether or not they can help you, and if so, how. INTJs know what they know, and perhaps still more importantly, they know what they don't know.Go ahead and give the test a try. It doesn't take long. There's a slightly different version you can also try. According to the Kiersey typology, I'm a Mastermind.
INTJs are perfectionists, with a seemingly endless capacity for improving upon anything that takes their interest. What prevents them from becoming chronically bogged down in this pursuit of perfection is the pragmatism so characteristic of the type: INTJs apply (often ruthlessly) the criterion "Does it work?" to everything from their own research efforts to the prevailing social norms. This in turn produces an unusual independence of mind, freeing the INTJ from the constraints of authority, convention, or sentiment for its own sake.
If you look at this page you can see that blogging is a perfect activity for an INTJ like me:
# Be willing to back up your statements with facts - or at least some pretty sound reasoning.Of course, other factors are at work in the individual. For example, I'm cripplingly shy in public and suffer from depression. I'm also deficient in self-discipline, as readers of this blog have learned, and ambition. So, you will not match your "type" one-on-one. There will be differences; sometimes major ones.
# Don't expect them to respect you or your viewpoints just because you say so. INTJ respect must be earned.
# Be willing to concede when you are wrong. The average INTJ respects the truth over being "right". Withdraw your erroneous comment and admit your mistake and they will see you as a very reasonable person. Stick to erroneous comments and they will think you are an irrational idiot and treat everything you say as being questionable.
# Try not to be repetitive. It annoys them.
# Do not feed them a line of bull.
# Expect debate. INTJs like to tear ideas apart and prove their worthiness. They will even argue a point they don't actually support for the sake of argument.
# Do not mistake the strength of your conviction with the strength of your argument. INTJs do not need to believe in a position to argue it or argue it well. Therefore, it will take more than fervor to sway them.
# Do not be surprised at sarcasm.
# Remember that INTJs believe in workable solutions. They are extremely open-minded to possibilities, but they will quickly discard any idea that is unfeasible. INTJ open-mindedness means that they are willing to have a go at an idea by trying to pull it apart. This horrifies people who expect oohs and ahhs and reverence. The ultimate INTJ insult to an idea is to ignore it, because that means it's not even interesting enough to deconstruct.
This also means that they will not just accept any viewpoint that is presented to them. The bottom line is "Does it work?" - end discussion.
# Do not expect INTJs to actually care about how you view them. They already know that they are arrogant bastards with a morbid sense of humor. Telling them the obvious accomplishes nothing.
Still, it's nice to know that one of my idols, Thomas Jefferson, is also INTJ.


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Natart Juvenile Bella Collection
Showing all 6 results
Natart Juvenile Bella 5 Drawer ChestMore Info
Natart Juvenile Bella ArmoireMore Info
Natart Juvenile Bella NightstandMore Info
Natart Juvenile Bella "5-in-1" Convertible Crib in CocoaMore Info
Natart Juvenile Bella "5-in-1" Convertible Crib in LinenMore Info
Natart Juvenile Bella Double DresserMore Info
Natart Juvenile Bellas is an elegant unisex group incorporating flowing arcs and a one-piece corner posts with tapering feet. It is built of 100% solid wood and offers aneternalplea. The collection is offered in three finishes: walnut, linen and cocoa. The linen finish is emphasized by pearlescent silver metal pulls, which are imported from Italy and darker tones are stable by solid wood handles, which are made in Canada. The sunken and covered back panel on the dresser strengthens unit's structure. The drawers are English merge, which also strengthens the unit's structure. The anti-pinch self-closing, slow motion, drawer glides have security locks and lifetime warranty; the drawer cannot be slammed shut.
Buy Natart Juvenile Alexa furniture to make your little prince or princess be sure to have sweet dreams.Natart JuvenileBellas has many kinds of productsthat suit all you need from bump to birth, all in one place.


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4 Wheel Parts Continues Sponsorship Of The Lucas Off Road Racing SeriesPosted in News on March 15, 2016
After a successful sponsorship of the popular Lucas Off Road Racing Series (LOORRS) last year, the team at 4 Wheel Parts has renewed their partnership with LOORRS for the 2016 season. 4 Wheel Parts, known for supplying off-road performance products for Jeeps, trucks, and SUVs, will be the official retailer of the action-packed short-course off-road racing series.
4 Wheel Parts will promote the Lucas Off Road Racing Series throughout its 74 stores in North America by carrying Lucas Oil products on the shelves and expanding the popular youth ticket program that offers complimentary tickets to kids 12 and younger for LORRS races.
CEO of 4 Wheel Parts, Greg Adler, was pumped to continue sponsorship of LOORRS, saying, "4 Wheel Parts has enjoyed a long and successful affiliation with our friends at Lucas Oil, we have their products on our shelves, we rely on them in our racecars and we connect with our customers through our participation in their series both as a sponsor and as a team. Our collaboration with Lucas demonstrates what can be achieved through a truly great partnership."
Not only is 4 Wheel Parts the official retailer of LOORRS, they will also be the title sponsor of the on the year-end series finale set to take place at Chandler's Wild Horse Motorsports Park in October.
This 16-round season should feature plenty of awesome short-course racing action from the Southern California dirt to the second running of the fun Mexican racecourse in Ensenada.
Check out the 2016 LOORRS race schedule below.:
Mar 19 - 20 Wild Horse Pass Motorsports ParkChandler, AZ
Apr 23 - 24 Lake Elsinore Motorsports Park Lake Elsinore, CA
May 21 - 22 Utah Motorsports Campus Tooele, UT
Jun 18 - 19 Baja International Short Course at Estero Beach Ensenada, MX (Pro classes only)
Jul 23 - 24 Glen Helen Raceway San Bernardino, CA
Aug 13 - 14 Wild West Motorsports Park Sparks, NV
Sep 23 - 24 Lake Elsinore Motorsports Park Lake Elsinore, CA
Oct 22 - 23 Wild Horse Pass Motorsports Park Chandler, AZ
For more information on the upcoming Lucas Oil Off Road Racing Series, check out lucasoiloffroad.com. To find your local 4 Wheel Parts store, visit 4wheelparts.com.


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A NEW report, Identifying the Roles of Pharmacy Technicians in the UK, produced by the School of Pharmacy at the University of East Anglia in collaboration with the Association of Pharmacy Technicians UK (APTUK), has found that pharmacy technicians (PTs) are located in community, hospital, primary care and medical practices and are undertaking an expanding variety of roles, many of which have traditionally been reserved for pharmacists.
There was a strong desire in the profession for expanding roles further, particularly around the provision of patient-facing services and taking on additional responsibility in management and leadership roles.
However, over a quarter of PTs, consulted in research for the report, did not believe that their pre-registration training adequately prepared them for their first day of practice, and a need was identified to enhance pre-registration training to include: clinical knowledge, communication, management, IT literacy and education skills, as well as accreditation for final checking.
The report identified a need for increasing the length of training to incorporate this new material and making the qualification degree-level was identified as the most appropriate solution. In addition, as there was currently no strategy for post-registration training, there was a need to develop post-registration career pathways and frameworks.
Barriers to the career development of PTs included: pharmacists, management, lack of understanding of the PT role, and lack of opportunities, whereas facilitators included the culture of the employing organisation and support from pharmacists, managers and other staff.
The recommendations from the report were:
- Review the education and training needs of pharmacy technicians in light of the roles and activities now commonly undertaken and the identified new knowledge and skills which need to be incorporated into pre-registration training.
- Consider qualification requirements for registration of pharmacy technicians, taking into account the complexity of roles undertaken, comparability with other similar healthcare professionals and the need for the profession to develop its own evidence base.
- Review post-registration education and training to ensure that opportunities exist which enable the preparation of PTs for the wide variety of roles.
- Develop a post-registration career framework to provide a career structure for registered PTs.
- Consider how the inter-professional working relationships with pharmacists can be enhanced both pre and post-registration to ensure that the contribution of both healthcare professionals is optimised.
- The management culture within pharmacy organisations with respect to pharmacy technicians requires review in order to develop strategies for improvement.
Visit the Association of Pharmacy Technicians UK (APTUK) website here.


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Hiking · Pokhara, Nepal
- 7 days
- 2 - 12 people
- Moderate
$759Per Person
Request to Book
Save to Wish List
This trek is the taste of Community based journey in Myagdi Annapurna, a perfectly nice and small circuit through the communities and natural areas, and is suitable for anyone including for family, through the beautiful villages and the dramatic viewpoint of 3300m with rhododendron forest.
Contact host
Mainly these months Oct. Nov, Dec, Jan, Fen, March, April and May
Anyone who loves to walk, explore the new and off the beaten path, real culture and people, contribute and enjoys the outdoor and nature too and also fit mentally
- 7 days trek on full board
- Guide
- Porter
- Local transportation from and to starting to end point of the trek
- Cultural evening and local visit
- Staff insurance and tax
- Anything that is not metioned above
Its on the off the beaten path, on the community trail, who are working together for the whole community and the country but not for personal and is helps them ..a trek of great cause! The cancellation of the trip will be as per company regulation and good/confirmed notice of two weeks is required
Full refund 2 days prior to tour.
Day 1Kathmandu/Pokhara/Galeshwor Tourist bus to Pokhara- 6 hours and car/taxi to Galeswor, starting point of trekking- 3 hours Overnight hotel LD
Day 2Trek to Bas Kharka A short hike and overnight community/homestay BLD
Day 3Trek to Nangi Trek to Nangi through Danda kateri a charming village. Overnight community lodge. Visit village for community project, provided time is available BLD
Day 4Trek to Mohare A great place for mountain views that are beyond word can describe. Overnight community lodge BLD
Day 5Trek to Tikot Another charming Magar village where you will use dinninig hall and community home stay BLD
Day 6Trek to Baisari and drive back to Pokhara Overnight hotel BL
Day 7Travel back to Kathmandu and trip ends
Per Person
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About Our Themes
We believe learning shouldn't be confined to a classroom. We believe your child's success later in life depends on the choices you make now.
Our Vision and Values
Connecticut River Academy graduates will use their gifts to contribute to a just and sustainable world.
CTRA values AWARENESS, DIVERSITY, & ACTION.
Our Magnet Standards
CTRA scholars will contribute to a just and sustainable world by:
Magnet Standard 1: demonstrating self- and global awareness.
- Using self-reflection to identify personal values, interests, strengths, and challenges
- Making plans and using strategies, resources, and innovative technologies and ideas to contribute to the well-being of self, others, and the environment
- Increasing global awareness to improve the efficacy and sustainability of decisions
- Using Habits of Mind and the design process to make choices that will positively affect our future
Magnet Standard 2: demonstrating a respect for the importance of diversity in the community of life.
- Communicating an understanding of how diversity affects our physical, social, economic, and cultural environments
- Seeking diverse, innovative ideas and relationships
- Making collaborative and informed decisions
Magnet Standard 3: demonstrating the impact of individual and social actions and decisions on the community of life.
- Communicating an understanding of how choices affect environments
- Acting individually and collectively to positively affect our environments and increase community ownership for learning
- Employing innovative manufacturing methods and technologies that improve the conditions of life
CTRA's Magnet Theme Days demonstrate our values:
Download Our 2016-2017 Vision, Values & Magnet Standards
Sustainability Theme
Sustainability: Making decisions to ensure the well-being of all life, including nature, economy, and society. At CTRA, we demonstrate this through awareness, diversity, and action.
The Connecticut River Academy Sustainability Theme includes two areas of study, Environmental Studies and Advanced Manufacturing.
Environmental Studies provides students with opportunities to experience first-hand what environmental scientists and engineers actually do. Students learn about relevant environmental and social issues such as climate change and green energy in the school's state-of-the-art laboratories and on its very own research vessel.
Students can also explore how current advancements in technology will shape the future of our planet with Advanced Manufacturing. Working hands-on with cutting-edge equipment and high-tech machinery such as 3-D printers and robotics, students gain experience in technologies including advanced manufacturing, engineering, and logistics.
Early College Model
In addition to a full range of high school courses, students grade 11-12 have the opportunity to earn up to 30 transferable college credits through our early college model. Unlike at many other high schools, our students get a head start on their college career while still in high school, all at no tuition cost. At the Connecticut River Academy, students are prepared academically and socially for college – laying an important foundation for their future success. Our students enjoy a curriculum filled with opportunities for hands-on learning and discovery – inside and outside the classroom.
Special Features
- Early College model with opportunities to earn 30 tuition-free, transferable college credits while still in high school
- Sustainability theme with a focus on the Connecticut River watershed area
- Hands-on learning including engineering and advanced technologies
- State-of-the-art technology including collegiate level science labs and laptop computers for every student
- Internship opportunities with high-tech corporations including advanced science and technology experiences
- Extended day for advanced enrichment, academic, and social supports
Habits of Mind as Learning Outcomes
Educational outcomes in traditional settings focus on how many answers a student knows. When The Connecticut River Academy teaches for the Habits of Mind, we are interested in how students behave when they don't know an answer. The Habits of Mind are performed in response to questions and problems, the answers to which are not immediately known. We are interested in enhancing the ways students produce knowledge rather than how they merely reproduce it. We want students to learn how to develop a critical stance with their work: inquiring, editing, thinking flexibly, and learning from another person's perspective. The critical attribute of intelligent human beings is not only having information but also knowing how to act on it.
To learn more, read our Habits of Mind Overview.
Connecticut River Academy is a featured school on the Teaching Our Cities website. Click here to see our page.
Success Stories


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Collaboration: $16.6M TB Grant
ISB will collaborate with Seattle BioMed and ETH Zurich on a $16.6 million tuberculosis grant from the National Institutes of Health. Seattle BioMed issued this press release today:
SEATTLE, AUG. 15 — Seattle BioMed has been awarded a grant from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, that will take a comprehensive systems approach to the problem of tuberculosis (TB) infection, harnessing the power of technology and systems biology to examine the progression from latent infection to disease.
The grant will total up to $16.6 million over a five-year period. One third of the world's population latently carries the bacterium that causes TB, and 8.7 million new cases of TB are diagnosed each year. The research will be focused on predicting which carriers will become actively ill with TB.
"Research in TB has never been more critical, and this collaboration represents an important change in how disease research is done, making a move from a 'trial and error' approach to predictive modeling," says Alan Aderem, Ph.D., president of Seattle BioMed. "By drawing on our collective expertise, and by taking advantage of the predictive power of systems biology, we can tackle the problem of TB in an entirely new way, potentially elucidating new drug targets or informing vaccine development."
The grant integrates the expertise of several scientists at Seattle BioMed, in collaboration with the Institute for Systems Biology (ISB) and ETH Zurich.
Alan Aderem will serve as Co-Principal Investigator (PI) of the program and Co-PI of the Omics Core.
David Sherman, Ph.D., is the Co-PI of the program and Co-PI of the Pathogen Project.
Kevin Urdhal, Ph.D., is the Co-PI of the Host Project.
Dan Zak, Ph.D., is the Co-PI of the Data Core.
Nitin Baliga, Ph.D., of ISB will serve as the Co-PI of the Modeling Core.
Ruedi Aebersold, Ph.D., of ETH Zurich will serve as Co-PI of the Technology Core.
The team of researchers comprises experts from both the host side of the disease and the pathogen side, along with authorities in the field of systems biology and biotechnology.
TB's transition from a latent infection to active disease is a complex process involving nuanced interactions between the bacterium that causes disease and the human immune system. The grant, titled "Omics of TB Disease Progression," will for the first time allow researchers to study many sides of TB infection simultaneously, uncovering the mysteries of how and in whom TB causes illness.
"With this project, we hope to identify genes in both humans and bugs that work together to cause disease," says Sherman. "It will give us the first comprehensive picture of how TB, a notoriously elusive pathogen, progresses to disease."
Globally, someone develops active TB disease every four seconds, and someone dies from TB every 20 seconds. Drug resistance is an enormous challenge in treatment, with 3.7 percent of new cases and 20 percent of previously treated cases resistant to at least one course of drug treatment. Totally drug resistant TB has also emerged in several countries. Additionally, HIV facilitates the latent-to-active transmissions of TB because it weakens the immune system. Although TB is the second-leading infectious disease killer worldwide, and the biggest disease killer of HIV-positive people, it receives far less research funding than either HIV/AIDS or malaria.
Seattle BioMed is the largest independent, non-profit organization in the U.S. focused solely on infectious disease research. Our research is the foundation for new drugs, vaccines and diagnostics that benefit those who need our help most: the 14 million who will otherwise die each year from infectious diseases, including malaria, HIV/AIDS and tuberculosis. Founded in 1976, Seattle BioMed has more than 330 staff members. By partnering with key collaborators around the globe, we strive to make discoveries that will save lives sooner. For more information, visit www.seattlebiomed.org.
Research reported in this press release was supported by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, under award number U19AI106761-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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New Study May Provide Knowledge for Increased Biofuel Production from Unicellular Algae
With potential ramifications for increasing biofuel production from unicellular algae, ISB's Drs. Mónica Orellana and Nitin Baliga, along with colleagues from the University of the Witwatersrand, used the chlorophyte algae Chlamydomonas reinhardtii to demonstrate the cell's metabolic and physiological changes of lipid accumulation that occurs during nitrogen depletion.
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Researchers at ISB reported a novel method, Path-seq, to profile expression of all MTB genes within infected mice. This study presents the most comprehensive transcriptome profiling of MTB from in vivo infection and a major technical advancement for studying any host-pathogen interaction.
Spotlight on Amy Zamora, ISB Systems Research Scholar
Amy Zamora joined ISB in August as a Systems Research Scholar. The Systems Research Scholars Program provides recent college undergraduates a springboard to become the next generation's pioneers of interdisciplinary scientific research. In this Q&A, Zamora describes her experiences at ISB, research interests, future aspirations, and much more.
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The Most Powerful Tool for Reconstructing a Gene Network
Scanning EM of bacteria being eaten by white blood cell Photo Credit: Adrian Ozinsky 3 Bullets: Nearly a decade ago, ISB's Baliga Lab published a landmark paper describing cMonkey, an innovative method to accurately map gene networks within any organism from microbes to humans. Two new papers describe the benchmark results of cMonkey and also the release of cMonkey2, which performs with higher accuracy. Using this approach, genetic and molecular…
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The National Institutes of Health announced the launch of a new Alzheimer's Big Data portal, which includes the first wave of data for use by the research community. This portal is the result of the Accelerating Medicines Partnership (AMP) program, which focuses on facilitating collaboration among government agencies, academia and industry in order to translate research more quickly to therapies. The launch of the AMP Alzeheimers Disease Knowledge Portal is…
Gov. Inslee Hosts Round Table With College Students at ISB
Gov. Jay Inslee hosted a round table discussion today at Institute for Systems Biology with a group of invited college students, who were asked to share their thoughts on the affordability of education. We were honored to be able to provide the venue. ISB has had a long history of supporting systemic change at the K-12 school district level to improve the quality and access of STEM education. Now, our…
Baliga Lab: 'The Universe Under a Microscope'
This is an excerpt from Environmental Microbiology Reports, 2015, authored by Arjun Raman, a postdoc in the Baliga Lab here at Institute for Systems Biology. The beauty of a living thing is not the atoms that go into it, but the way those atoms are put together. Information distilled over four billion years of biological evolution. Incidentally, all the organisms on the Earth are made essentially of that stuff. An…
Tuberculosis Research: A 'Molecular Road Map' to Help Understand Gene Regulation
The journal "Trends in Microbiology" recently published a spotlight article on a tuberculosis research collaboration between scientists at Institute for Systems Biology and Seattle BioMed. The paper "The DNA-binding network of Mycobacterium tuberculosis" was published in the journal "Nature Communications" (Jan. 12, 2015): "MTB employs about 200 different molecular switches to sense and respond to the shifting, hostile landscape of the host. To identify and understand the intertwining gene regulatory…
ISB Gets $1.7M to Study Cancer Drug Resistance
Congratulations to the Sui Huang Lab at ISB which has received a five-year $1.7 million R01 award from the National Institutes of Health and National Institute for General Medical Sciences to study cancer sub-population dynamics to understand and develop drugs to inhibit lethal cancer-drug resistance. The project proposal states that the work will: "develop a quantitative and formal framework for describing the temporal evolution of cell phenotype distribution in a…
Tuberculosis: 'The Forgotten Plague'
PBS: American Experience Film "The Forgotten Plague" BY ISBUSA The measles outbreak and subsequent fueling of the anti-vaccination debate have monopolized headlines recently. But there's a "plague" that causes an estimated 1.3 million deaths per year that researchers, including those at Institute for Systems Biology, are dedicated to tackling: tuberculosis. On Tuesday, Feb. 10, PBS will feature an "American Experience" film "The Forgotten Plague" on the history of tuberculosis and…
Into the genetic weeds of hair growth
3 Bullets: ISB researchers used a data-driven mathematical model to identify specific genes associated with hair regeneration Novel methodology paves way for continued research into the molecular basis of this complex cycle as well as other regenerative organs like skin and liver Findings may lead to more precise targets for therapies and genetic markers of hair wellness By Varsha Dhankani Scientists at ISB have identified genes associated with the growth-and-death…
Pushing the Molecular Switches of Tuberculosis Into Overdrive to Map Interactions
3 Bullets: Mycobacterium tuberculosis (MTB) infects more than 1.5 billion people worldwide partly due to its ability to sense and adapt to the broad range of hostile environments that exist within hosts. To study how MTB controls its responses at a molecular level, ISB researchers and their collaborators at Seattle Biomed perturbed almost all MTB transcription factor regulators and identified the affected genes. This comprehensive map of molecular switches in…
4 Minutes of Green Gold: Watch Algae Grow
There's something calming about watching algae grow. What you see in the tubes are two types of algae: Thalassiosira pseudonana or "Thaps" is the brown diatom. Chlamydomonas reinhardtii or "Chlamy" is the green algae. We use Thaps to study ocean acidification and Chlamy is for studying biofuel production.
How One Family of Microbial Genes Rewires Itself for New Niches
3 Bullets: When an organism duplicates its genes, it increases its ability to adapt and colonize new environments. ISB researchers used the systems approach to study how one family of microbial genes evolved to bring functions that were adaptive to specific environments. This new understanding of how gene regulatory networks rewire themselves has many potential applications, including how to wire new functions into an organism for biofuel production, bio-remediation or…
Cancer Genomics Cloud: ISB and Google Featured in MIT Tech Review
(Above illustration from MIT Technology Review.) MIT Technology Review published an article about the launch of Google Genomics and included a mention of ISB's new Cancer Genomics Cloud project. ISB received an up-to $6.5 million, two-year NIH contract in collaboration with Google and SRA International. From the MIT Technology Review article: The idea is to create "cancer genome clouds" where scientists can share information and quickly run virtual experiments as…
How Physics and Thermodynamics Help Assess DNA Defects in Cancer
3 Bullets: 'Big data' cancer research has revealed a new spectrum of genetic mutations across tumors that need understanding. Existing methods for analyzing DNA defects in cancer are blind to how those mutations actually behave. ISB scientists developed a new approach using physics- and structure-based modeling to systematically assess the spectrum of mutations that arise in several gene regulatory proteins in cancer. By Jake Valenzuela and Justin Ashworth A significant…
A New Approach to Identifying How the Deadly Dengue Virus Multiplies
3 Bullets: Dengue virus is the most prevalent mosquito-borne virus worldwide, infecting an estimated 400 million people per year and causing about 25,000 deaths. It's necessary to understand the molecular mechanisms of dengue replication in order to develop an effective treatment. Researchers at ISB and Seattle BioMed developed a novel approach for identifying host proteins that associate with dengue replication machinery. By Thurston Herricks Dengue virus (DENV) infects approximately 400…
New Details on Thyroid Cancer May Lead to More Precise Therapies
3 Bullets: Papillary thyroid cancer represents 80 percent of all thyroid cancer cases. Integrative analysis resulted in the detection of significant molecular alterations not previously reported in the disease. ISB researchers identified microRNAs which may lead to more precise therapy. By Lisa Iype Papillary thyroid cancer (PTC) is the most common type of thyroid cancer, accounting for 80 percent of all cases. As part of The Cancer Genome Atlas (TCGA)…
ISB Awarded $6.5 Million NIH Contract to Develop 'Cancer Genomics Cloud' with Google and SRA International
PRESS RELEASE Institute for Systems Biology (ISB) has received a $6.5 million, up to two-year, federally funded contract from the National Cancer Institute (NCI), National Institutes of Health (NIH). ISB is one of three organizations awarded a contract by NCI to develop a cloud-based platform that will serve as a large-scale data repository and provide the computational infrastructure necessary to carry out cancer genomics research at unprecedented scales. ISB's Shmulevich…
ISB 2014 Retreat
ISB held its all-staff retreat in Leavenworth on Sept. 8 and 9. In order to do the kind of science we do, we need time away to connect with one another, recharge and envision big ideas. While there are plenty of sessions on our science, there are also plenty of opportunities to have a little fun. This year, we held an "open-mic" night. Several ISB staffers performed – including Dr….
PROJECT BIOTECH Summer Camp Report
Photo above: Students participating in PROJECT BIOTECH Summer Camp. Photo credit: Shoreline Community College By Dina Kovarik Project Manager, Baliga Lab The Shoreline Community College (SCC) Biotech Program and the Amgen Biotech Experience (ABE) program partnered with the Institute for Systems Biology (ISB) to develop a one‐week summer camp for high school students called PROJECT BIOTECH. The camp took place at SCC on July 7‐11, 2014. While the Puget Sound…
New Tool Uses 3-D Protein-DNA Structures to Predict Locations of Genetic 'On-Off' Switches
3 Bullets: Novel systems approach uses high-resolution structures of protein-DNA complexes to predict where transcription factors (genetic switches) bind and regulate the genome. This approach can help researchers better understand and predict binding sites for non-model organisms or 'exotic' species. Having such insight and predictive capabilities is critical for reverse- and forward-engineering organisms that could be pivotal for new green biotechnologies. By Jake Valenzuela and Justin Ashworth Researchers at the…
ISB Gets $2.3 million NIH Grant to Use Single-Cell Technology to Fight Cancer
Pictured above: Dr. Qiang Tian, left, and Dr. Edward Lin, right, discuss single-cell analysis technologies developed at Institute for Systems Biology in Seattle. September 22, 2014 – ISB has received a $2.3 million NIH grant over four years in response to NCI's "Provocative Questions" Initiative. The project will apply ISB's most advanced single-cell omics technologies to an innovative clinical trial for colorectal cancer (ADAPT). Principal investigator Qiang Tian, MD, PhD,…
Baliga Lab: Uncovering the Genetic Adaptability of Tuberculosis
3 Bullets: The Institute for Systems Biology and Seattle BioMed have collaborated to reconstruct the gene regulatory network of the human pathogen Mycobacterium tuberculosis. Finely tuned gene regulation has allowed Mycobacterium tuberculosis to survive unnoticed in an apparently healthy host for decades; understanding those subtleties is critical for advancing treatment. The identification of co-regulated sets of genes and their regulatory influences offers validated predictions that will help guide future research…
Tracking Cells from Well to Diseased
KUOW's Marcie Sillman and producer Amina Al-Sadi interviewed Dr. Lee Hood about P4 medicine and the 100K Wellness Project. This 29-minute recording is a great conversation about Lee's vision for how to turn healthcare on its head. Listen to the podcast. Learn more about the 100K Wellness Project.
New $10.9 Million Grant from NIH
The NIH's National Institute of General Medical Sciences has issued a Biotechnology Resource Grant of $10.9 million over five years to the National Center for Dynamic Interactome Research (ncdir.org) project. This project is a collaboration among The Rockefeller University, Institute for Systems Biology, Seattle BioMed, University of California at San Francisco, New York University and New York Structural Biology Center. Michael Rout, of The Rockefeller University, is the Program Director/Principal…
ISB Researchers Help Identify Four New Subtypes of Gastric Cancer That May Lead to New Targeted Treatments
3 Bullets: Gastric cancer has a high mortality rate, but current classification systems haven't been effective in helping to identify subtypes relevant for treatment of the disease. TCGA researchers have integrated molecular data from 295 stomach tumors and have discovered four subtypes of gastric cancer. Stratification of patients into these four subtypes paves the way for the development of new personalized therapies. By Theo Knijnenburg Gastric cancer is among the…
New Open-Access Multiscale Model Captures Dynamic Molecular Processes in Unprecedented Detail
3 Bullets: Microbes are efficient because their streamlined genomes allow them to evolve and adapt rapidly to complex environmental changes. Decoding the highly-compressed information within a microbial genome requires sophisticated systems biology tools to map the genetic programs, and understand how they are executed. ISB researchers invented novel algorithms to unzip and decode microbial genomes into the EGRIN 2.0, an open-access multiscale model that captures instructions for executing the dynamic…
ISB's 2013 Annual Report is Now Available
Institute for Systems Biology has a dizzying breadth of research projects. But when we talk about what we do, it's how we do it that matters most. The systems approach that we pioneered and exemplify continues to distinguish our ability to tackle the most complex biological and environmental challenges today. Because of how we apply our hallmark collaborative, cross-disciplinary and integrative approach, our collective success is greater than the sum…
ISB Researchers Identify New Protein Modification Critical to Growth of Tuberculosis Pathogen
3 Bullets: Institute for Systems Biology and Seattle BioMed researchers collaborated and discovered a new protein post-translational modification in the human pathogen Mycobacterium tuberculosis. Post-translational modifications are essential mechanisms used by cells to diversify protein functions and ISB scientists identified the rare phosphorylated tyrosine post translational modification on Mycobacterium tuberculosis proteins using mass spectrometry. Inhibiting phosphotyrosine modified amino acids in Mycobacterium tuberculosis severely limits the growth of this widespread deadly…
3-Minute Science: ISB and Seattle BioMed Hold Annual Lightning Talks
Photo: Theo Knijnenburg, a research scientist in ISB's Shmulevich Lab, presentaed a summary of his work related to gene mutations and cancer drug sensitivity. Systems biology is about the culture as much as a scientific approach. ISB and Seattle BioMed have an inter-institutional agreement that enables the collective to benefit from shared knowledge and technology resources. For the second consecutive year, we held Lightning Talks (June 12) to allow researchers…
LAB NOTEBOOK: Evolution Beyond Darwin
(Photo: Dr. Sui Huang presenting during an ISB systems biology discussion group on May 15, 2014.) LAB NOTEBOOK: At ISB, we hold systems biology discussion groups every Thursday during lunch. The topics vary from week to week, but the intention is to inspire exchanges amongst our staff. Today's discussion group was presented by Dr. Sui Huang – our resident theorist, who always poses just the right question to provoke thought…
Melding ISB and FHCRC Brain Power for Cancer Research
(Photo above: ISB's Dr. Ilya Shmulevich describes his lab's work in The Cancer Genome Atlas project and how ISB and FHCRC could collaborate.) Big health challenges require big science. Cancers are prime examples of overwhelmingly complex diseases that need the power of a cross-disciplinary, systems biology approach to decipher the underlying dysfunctional gene networks in order to find ways to prevent and manage the diseases and develop more effective therapies….
100K Wellness Project Article by Lee Hood and Nathan Price in Clinical Omics
The latest press about the 100K Wellness Project is in the May 15 issue of Clinical Omics and features a piece by Dr. Lee Hood, president of Institute for Systems Biology (ISB), and Dr. Nathan Price, ISB's associate director. Read "Promoting Wellness and Demystifying Disease: The 100K Project"
ISB In the News: NIH, Viral Networks and Systems Biology
Emily Carlson and Sharon Reynolds, of the National Institutes of Health/NIGMS, posted a story on NIGMS's Inside Life Science as well as on Livescience.com on how systems biology is a powerful approach to studying biological networks. The article included comments from ISB scientist Aaron Brooks and senior research engineer Chris Lausted who created a network activity that they presented during the USA Science & Engineering Festival in Washington D.C. on…
It's National Cancer Research Month: How To Help
May has been designated "National Cancer Research Month" and we'd like to share a little about how ISB is using the systems biology approach to tackle some of the complexities of researching cancers. You can read our four-part series on how ISB's pioneering systems biology has made an impact and continues to clear new pathways for the cancer research field. Please visit aacr.org to learn more about NCRM. Support ISB's…
Cancer Detection: A Systems Biology Approach
By Martin Shelton ISB Editorial Board Member With the exception of cancers of the skin, mouth, and blood, it is difficult to detect cancer by sight or with a routine health screen. The natural variety that exists at the cellular level — even within cells of the same type — challenges our ability to differentiate healthy tissue from diseased. This variety, what biologists call heterogeneity, means that equally healthy cells…
ISB at USA Science and Engineering Festival
ISB scientists Aaron Brooks (Baliga Lab) and Martin Shelton (Hood Lab) attended the USA Science & Engineering Festival in Washington D.C. on April 26-27. They, and ISB senior research engineer, Chris Lausted, developed an interactive network activity involving circuit boxes that represent nodes and fiber optic cables to connect them. The project and trip to D.C. were supported by funds through NIH/NIGMS and ISB's Center for Systems Biology. From Brooks:…
Data Vis Meetup Held at ISB
Pictured above: Allison Kudla presents ISB's Big Data Science site at the start of the meetup. ISB hosted the Seattle Vis meetup group this past Wednesday (April 30). The meetup was organized by Noah Iliinsky and facilitated by ISB's Dick Kreisberg. The guest speakers were Ryan Lucas and Kevin Lynagh, who have created a very stylistic charting library based on a grammar of graphics. They are an independent data vis…
Free Systems Science Workshop for High School Teachers
FREE SUMMER SYSTEMS SCIENCE WORKSHOP AT ISB FOR TEACHERS: Registration for the summer systems science workshop for high school science, math and CTE teachers is now open. The workshop is hosted by Claudia Ludwig and Dina Kovarik, of the Baliga Lab at ISB, and takes place July 21-25. The focus is on how to implement systems science in the classroom. For more information about the workshop, please visit this site….
Systems Biology + Systems Art
(Photo above: Artist Xiao Dong Feng and Dr. Lee Hood raise a toast during a reception on April 28. Feng's painting "Qing Xu" hangs in the background. The name is symbolic of someone who eschews earthly materialism and is instead a visionary who seeks a higher or more spiritual understanding.) On April 28, Institute for Systems Biology hosted an intimate symposium on Systems Biology & Systems Art in honor of…
ISB Impacts Education System Nationally and Locally
National: At the beginning of April, Dana Riley Black, ISB's Director of Education, was invited to participate in one of three Ideas Labs hosted by the National Science Foundation in Washington D.C. The weeklong lab was related to the new NSF program "Improving Undergraduate STEM Education" (IUSE) and was focused on discussing ideas for integrating quantitative literacy into undergraduate biology education. The reason for this particular topic is that while…
ISB's Annual Symposium
ISB held its 13th Annual International Symposium: Systems Biology & Cancers From Big Data to Personalized Treatment on April 13-14, 2014. Visit symposium.isbscience.net for details. Visit the gallery for images. Or visit the video playlist on ISB's YouTube channel.
ISB's Robert Moritz Lab Receives NIGMS Grant for Trans Proteomic Pipeline
The National Institute Of General Medical Sciences of the NIH has awarded Principal Investigator(s): Eric Deutsch, PhD, and Robert L. Moritz, PhD, a continuing R01 grant GM087221 for the ongoing development of the Trans-Proteomic Pipeline. The award titled "Development of Trans Proteomic Pipeline, an Analysis Suite for Mass Spectrometry" will continue the work of the ISB flagship proteomics analysis suite of open-source programs that has been downloaded thousands of times…
Summer Course Registration Is Now Open!
Summer Course: Systems Biology of Disease Register Now Offered by Institute for Systems Biology and Center for Systems Biology Course Objective The goal of this course is to introduce the core concepts of systems biology and their application to systems biomedicine. We will demonstrate the importance of cross-disciplinary interactions for the success of systems biology programs. When July 28 – August 1, 2014 9 am to 5 pm Where Institute…
ISB at Town Hall Seattle: Systems Biology & Cancers
On March 27, 2014, ISB and Town Hall Seattle co-presented a panel discussion on "Systems Biology & Cancers: From Big Data to Personalized Treatment." Panelists included ISB president, Dr. Lee Hood; Dr. Tony Blau, of UW's Division of Hematology, Department of Medicine; Dr. Peter Nelson, prostate cancer researcher and oncologist at Fred Hutchinson Cancer Research Center; and moderator Dr. Eric Holland, Senior VP and Director of the Human Biology Division…
ISB at Town Hall Seattle: Systems Biology & Cancers
On March 27, 2014, ISB and Town Hall Seattle co-presented a panel discussion on "Systems Biology & Cancers: From Big Data to Personalized Treatment." Panelists included ISB president, Dr. Lee Hood; Dr. Tony Blau, of UW's Division of Hematology, Department of Medicine; Dr. Peter Nelson, prostate cancer researcher and oncologist at Fred Hutchinson Cancer Research Center; and moderator Dr. Eric Holland, Senior VP and Director of the Human Biology Division…
Mark Calendars for Dr. Lee Hood's Reddit AMA on April 11
Dr. Lee Hood will participate in a Reddit AMA (Ask Me Anything) on March 24 April 11 from 10-11 a.m. PST. There will be more details posted on Reddit.com the morning of April 11. For now, feel free to look at the list of upcoming science AMAs or check out some previous science AMAs here.
NOAA Ocean Acidification Webinar for Communicators & Educators
NOAA National Marine Sanctuaries and Ocean Acidification Program is holding a webinar series starting March 19 through June on the topic: "Sharing Ocean Acidification Resources for Communicators and Educators." ISB's Claudia Ludwig, the Education Program Manager in the Baliga Lab, will present: Ocean Acidification: A Systems Approach to a Global Problem When: Wed., April 23, 2014, 3 p.m. PST (6 p.m. EST) Primary Audience: Teachers, Formal Educators Project Website: http://baliga.isbscience.net/drupal/education/?q=content/ocean-acidification-systems-approach-global-problem…
NOAA Ocean Acidification Webinar for Communicators & Educators
NOAA National Marine Sanctuaries and Ocean Acidification Program is holding a webinar series starting March 19 through June on the topic: "Sharing Ocean Acidification Resources for Communicators and Educators." ISB's Claudia Ludwig, the Education Program Manager in the Baliga Lab, will present: Ocean Acidification: A Systems Approach to a Global Problem When: Wed., April 23, 2014, 3 p.m. PST (6 p.m. EST) Primary Audience: Teachers, Formal Educators Project Website: http://baliga.isbscience.net/drupal/education/?q=content/ocean-acidification-systems-approach-global-problem…
Slow Motion Video Booth at ISB
Institute for Systems Biology held its holiday party on Jan. 18, 2014. We hired Super Frog Saves Tokyo to set up a slow-motion video booth and this was the result. It's never boring at ISB! Doing systems biology research is serious work. But that doesn't mean we can't be irreverent. I encourage you to take a moment to watch the really, really fun video from our holiday party. We worked…
Science Education Impact
The educators who work at ISB continue to influence how science is taught in the State of Washington. Claudia Ludwig and Dina Kovarik, members of the Baliga Lab education team, recently helped the Highline School District apply for a $1,000 grant to use toward systems science materials and teacher training. Highline's Arts and Academics Academy received the award, which will also provide students with "real-world" lab experience.
ISB, Lee Hood on Forbes.com
John Nosta, a contributor to Forbes.com, posted this piece today and included a mention of a collaboration between Indi and ISB on a diagnostic that may help identify benign lung nodules. From Diagnosis to Treatment, Has Lung Cancer Begun To Turn The Corner? This study suggests the tremendous power of using systems biology and bioinformatics to better understand health and disease," said Lee Hood, M.D., Ph.D., co-author of the study; co-founder…
Lee Hood's 75th Birthday Party Photo Gallery
Dr. Lee Hood's 75th birthday party took place at ISB on Oct. 10. Here's the photo gallery. As part of the presentations, Dr. Nitin Baliga (ISB's Director and SVP) shared a fun video he made using footage he shot during the faculty retreat. Exactly how many PhDs does it take to find a Prius battery? Watch and find out:
Connecting the Dots: The Social Life of Genes
WHAT YOU SAW IN THE NEWS: Pacific Standard Magazine published the following cover story in September 2013: The Social Life of Genes "Your DNA is not a blueprint. Day by day, week by week, your genes are in a conversation with your surroundings. Your neighbors, your family, your feelings of loneliness: They don't just get under your skin, they get into the control rooms of your cells. Inside the new…
NIH Awards $45M to Alzheimer's Research
The National Institutes of Health announced $45 million in grants to support several research groups that are focused on Alzheimer's prevention. ISB's Price Lab will be working with the University of Florida to use systems biology to identify new therapeutic targets in the innate immune system. The systems approach, which ISB pioneered, allows scientists to integrate and analyze disparate data (genome, gene expression, pathology) in order to find the molecular…
$500K Proof of Concept Grants Awarded to ISB Scientists
Photo: ISB's Jennifer Smith speaks to Jose Banda, superintendent of Seattle Public Schools, in this archived photo. Jennifer just received a $250,000 grant from the Life Sciences Discovery Fund. The Life Sciences Discovery Fund announced the recipients of $1.25 million in Proof of Concept grants. ISB's Brady Bernard, of the Shmulevich Group, and Jennifer Smith, of the Aitchison Group, each will receive grants totaling almost $500,000. From the LSDF press…
Connecting the Dots: NPR TB Story
WHAT YOU HEARD IN THE NEWS: NPR aired this story (on Sept. 5) about research just published in the journal Nature Genetics suggesting that tuberculosis may have existed more than 70,000 years ago. Tuberculosis Hitched a Ride When Early Humans Left Africa ' "The old, traditional view was that tuberculosis emerged during the Neolithic transition when people started to domesticate animals and develop agriculture, which started about 10,000 years ago,"…
Open Science: A Hack Your PhD Interview with Dr. Nitin Baliga
Célya Gruson-Daniel, the founder of HackYourPhD, has been traveling across the United States to make a documentary about open science. She stopped by ISB on Aug. 5, 2013, to interview Dr. Nitin Baliga, who is our senior vice president and director. The short interview is below. Learn more about the Hack Your PhD documentary at this site: http://hackyourphd.org/USA
K-12 Science Education: MESA Math Scholars Visit ISB
Just as the Seattle tourist traffic picks up in the summer, the intern and visitor traffic at ISB spikes during July and August. It's always inspiring to see the fresh faces of high school students in our halls. On Aug. 7, the MESA Math Scholars came to ISB to visit our labs and spend some time with a few of our scientists. MESA stands for Mathematics, Engineering, Science Achievement and…
Ranish Lab Receives $156K Grant
Congratulations to ISB faculty member Jeff Ranish and his group on receiving a new grant for $156,000. The award is for collaborative work with Peter Myler at Seattle BioMed on "Base J and transcription termination in Leishmania." Here's the public health relevance statement from the proposal: Human infections with the various species of Leishmania parasite cause substantial morbidity and mortality in tropical and sub-tropical countries world-wide. These organisms appear to…
Why Does Lee Hood Travel So Much? He's a Man on a Mission
Dr. Lee Hood believes that ISB scientists are missionaries who are spreading the power of systems biology. He is always on the road and today (June 24) he's in Lyon, France, to attend the EISBM Symposium 2013 to give a talk on P4 medicine. Prior to arriving in Lyon, Lee was in Jerusalem to give a talk at the Israeli Presidential Conference, which drew world leaders such as Bill Clinton…
ISB Recieves $1.8M Grant for Ocean Acidification Research
Congratulations to Dr. Mónica Orellana and Dr. Nitin Baliga on their new grant for $1.8 million from the National Science Foundation. The project title is "Ocean Acidification: A Systems Biology Approach to Characterize Diatom Response to Ocean Acidification and Climate Change." Abstract from the proposal: Diatoms account for approximately 40 percent of primary production in the world's oceans and are the most productive marine phytoplankton group. They form the basis…
We Study Microbes Because It's Good for Your Health
Here's a piece adapted from Michael Pollan's latest book "Cooked: A Natural History of Transformation" which discusses how processed foods and the modern diet have made us more obese and more likely to get sick. He makes a case for eating more fermented foods that haven't been pasteurized – probiotics, live-culture foods – in order to get the good bacteria back in our guts. At ISB, the microbiome is an…
Luxembourg-ISB Partnership: 'An Unqualified Success'
By Hsiao-Ching Chou LUXEMBOURG JOURNAL, June 12, 2013 – At the 17th-century Neumünster Abbey, the cultural heart of Luxembourg City, a small group of some of the world's most cutting-edge scientists gathered on June 10-11, 2013, for a symposium to discuss the future of medicine and healthcare. The consensus was clear: Achieving the greatest advances requires "no-box" thinking, cross-disciplinary teamwork and, as ISB president, Dr. Lee Hood, likes to say,…
Scenes from Luxembourg
ISB is co-hosting a scientific symposium with Luxembourg Centre for Systems Biomedicine in Luxembourg City on June 10-11. Here are some scenes from Luxembourg pre-symposium. The full set of images can be found at this link: http://www.flickr.com/photos/90930918@N08/sets/72157634024779425/
In the WSJ: Dr. Lee Hood Explains How Nonprofits Can Be Entrepreneurial
Our Dr. Lee Hood is a guest mentor for The Wall Street Journal's Accelerators blog. In this post, he shares how nonprofit organizations can borrow the entrepreneurial and audacious-goal-oriented spirit of startups to be successful – in addition to remaining true to their missions. An excerpt: …achieving your vision requires determined optimism, the will to never give up, a missionary passion for the concept (to convince the skeptics), a willingness…
ISB Hosts TCGA Meeting
Ilya Shmulevich, PhD, shares this message about our hosting a TCGA (The Cancer Genome Atlas) steering committee meeting at ISB. In the video below, Ilya explains the purpose of the meeting and chats briefly about "pan-cancer" – the effort to find commonalities among multiple cancers. Related content: Read about ISB's role in TCGA as a Genome Data Analysis Center and about the most recent collaborative paper on endometrial cancer, which…
Systems Biology and Systems Medicine Curriculum in Middle and High Schools?
By Dana Riley Black, Director of ISB's Center for Inquiry Science Healthcare continues to be listed as a "high-demand" field, meaning there continue to be significant and projected employment opportunities in the field. A recent employment gap analysis by Washington State released on April 3 suggests a projected deficit of 472 healthcare jobs filled annually in the state (see: http://www.wtb.wa.gov/HighDemandFields.asp). As a result, many middle and high schools are turning…
2013 ISB Symposium: Systems Biology & the Brain
What will the next decade hold for brain science? At ISB's 12th Annual International Symposium: Systems Biology and the Brain, which took place on April 14-15, we began exploring this question. With the announcement in January about the European Commission awarding $1.29 billion to The Human Brain Project (based in Switzerland) and the news in February that the Obama administration would be announcing a $3 billion plan to support the…
ISB Brain Research
ISB held a panel discussion at Town Hall to discuss the complexity of the brain. It was a thought-provoking evening that attracted about 200 attendees. If you can't see the embedded video, click on this link: Town Hall video Read Karlyn Beer's column in Xconomy on why systems biology is necessary for tackling the complexity of the brain. RELATED: ISB's International Symposium: Systems Biology and the Brain info
ISB Takes 1st Place in YarcData Contest
Dr. Brady Bernard, Andrea Eakin, and Dr. Ilya Shmulevich, of The Institute for Systems Biology (ISB), were awarded first prize and will split $70,000 for their winning entry researching more than 25 different types of cancers and thousands of patients to gain insight into the biological networks that are disrupted or altered within a given cancer type and to identify potentially potent approved drugs that could be repurposed for the…
Connecting the Dots: Obama's Plan to Map the Brain
What You Saw in the News: On Feb. 18, The New York Times published a front-page story headlined "Obama Seeking to Boost Study of Human Brain." (Download PDF: ObamaNYTBrainMap.) While the administration has not formally announced this brain mapping project, the NYT was able to gather enough details from scientists involved in planning the project to publish a report. Participating government agencies and private foundations include the…


text: I'm in a chapter in my life where staying motivated is necessary. I have a goal of completing my PhD dissertation next Summer 2019. This means that I had to create very specific and strict goals in order to meet that timeline. It means I have to stay super motivated. For the most part I am, but I certainly have my days and weeks where I'm not.


text:
It is important that the Cultural Plan remain useful: a pertinent, effective tool for use by city staff and the community. To ensure this, staff of the Office of Arts and Culture will conduct a "refresh" this year. This process of engagement and research will ask four questions:
- What is working that we should reinforce?
- What is not working that we should fix?
- What new projects should we start?
- What did we not imagine three years ago?
To help us refresh the Community Cultural Plan, keep an eye on this page. And, make sure you are receiving our newsletter.


text:
Happy New Year from Google – here is a Pigeon!
Whilst we were busy preparing for Christmas and the traditional Aussie Holiday break by the beach (check out our favourite holiday spots for relaxing — see picture above), Google was busy rolling out their latest algorithm update – Pigeon, here in Australia, the UK and Canada. It may be something about Christmas as they had already rolled it out in the US on July 24th – and we know how they love a Christmas in July! Like other algorithm updates, the Pigeon update had quite an impact on not just search engine results, but local search results as well. Due to the Pigeon update, Google web searches and map searches are now more clearly connected to each other, thus showing more similar results. This may have also been due to the backlash from directories like Yelp who had previously cried foul and provoked Google with claims of anti competition. Others claim it is all about pushing advertisers to Adwords due to geographical limitations. This is considered to be a big change as Google web search results were often quite different to Google map search results. Another one of the the most significant Pigeon changes that had SEO specialists in the US scrambling to pick up their rankings was the loss of local map results. The local map results, otherwise known as the '7 Pack Results' were essential for local listing or boosting local search rankings. Many anomalies and spam implications are still being debated on forums globally and some even espouse a rollback of some description so stay tuned. I imagine it may take months for the dust to settle here. Here are some of the Pigeon manifestations that have affected Australian businesses in January: 7 Pack Results were less focused on Google My Business, Google+ or other such Google listing pages, and were featuring businesses who had actual websites or webpages. More attention and exposure was given to businesses who have listed on popular local online directories such as Yelp, Yellow Pages and TrueLocal. In particular those with reviews. Businesses who have clearly put an effort into their website were rewarded with better search rankings, especially for local...Read More
Welcome to Zoom Digital!
Hello and welcome to our Zoom Digital website, where we put the heart into digital! Here at Zoom Digital we provide digital marketing solutions for small and medium business owners. We have a variety of online services available from website development and design to online marketing strategies like search engine optimisation and more. We are a passionate team of web developers, designers, content marketers, etc. who want to show more support to the small and medium businesses of Australia. Even if we're open to handling bigger business clients, our hearts are more inclined to giving the smaller businesses a fighting chance! Competing in the world of business is rough, and we understand that because we run a business as well! We shouldn't be let down that easy just because it's difficult though, because there are always people like us who are willing to help! We think it's important for a growing business to establish an online presence, as we live in quite a technologically advanced world right now. We like to believe that once a business has its own up and running website, people (namely potential customers) are more likely to see that it exists! Our efforts don't just stop at creating your website too, as we have search engine optimisation and other online marketing services to boost its online performance! We try our best to help your website rank well in popular search engines like Google, so you can generate more traffic and gain more customers! Once we have finished your website and given you everything you need to run your business online, don't think we'll just up and leave! Even if you don't have any active projects with us, we'll still always be available to handle any technical issues or difficulties. We always welcome calls from past, present and future clients! So feel free to browse our website and check out the services we have to offer you. If any of them spark your interest, don't hesitate to call us or email us at...Read More


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Chantaé Polite
Chantaé Polite moved from her hometown of Tampa, Florida in 2013 to attend graduate school in DC. She fell in love with the district and the people and decided to build a community here. Chantaé completed her training at Yoga District's Registered Yoga Teacher Intensive training in Outer Banks, North Carolina. Chantaé has worked with children and teens for over five years through different mentorship, outreach, and art therapy programs. She uses compassion and playfulness to help others build awareness and self-confidence. Chantaé has studied the yoga styles of Vinyasa Flow, Power Yoga, Dharma Yoga, Restorative Yoga, Chair Yoga, and breathing and meditation techniques. As a landlocked beach bum she fills her days practicing and teaching yoga, reading, paddle boarding, biking, and tinkering with her ukulele.


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Another rough day at the hospital, so another short post for you guys. Hope to get some chance to write more tomorrow.
Explanation and Rules
Since I am addicted to The Singing Bee and since I'm having to work on my vocals for the JuRods and the Butterflies, I thought that I would throw a little contest your way.
I'll post some snippets of song lyrics and you'll guess the song. Whoever gets the most right by December 1st will get some sort of something from me. And I'm only having it be for my regular commentors, because, I'm making the rules and that's what I want. So there.
Some are pretty common, some obscure. I'm just going off of the list he made. But, he gave me a ton of songs, so hopefully they will be pretty random.
PS. No Googling! You have to guess!
You can spend all your time making money
You can spend all your love making time
If it all fell to pieces tomorrow
Would you still be mine?


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Rev. Ricardo Tavárez – Pastor
Rev. Tavárez is a second-generation Latino immigrant of Dominican and Puerto Rican decent, who has spent most of his life in Grand Rapids. At a young age, he grew a passion for accessing skills and resources that he could bring into urban areas of the city, while building up minority community leaders. He earned a dual undergraduate degree at Kuyper College in Bible and International Business. He later graduated from Calvin Theological Seminary with a Master's Degree in Divinity. In 2016, Rev. Ricardo R. Tavarez felt called to start En Vivo Church, in his own backyard, that being the Burton Heights neighborhood. Rev. Tavárez remains passionate about equipping urban leaders with cross-cultural leadership and ministry skills, while advocating for those pushed to the margins of society. Ricardo loves traveling, the arts and specifically theatre. One of his dreams is that En Vivo church will be a platform where artistic expression takes place.


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FJM Security Products HS7100-SWL Silver Steering Wheel Lock
- List Price:
- Sale Price: $111.98
- Amount Saved: $29.03
- Availability: Usually ships in 6-10 business days
- Heavy duty hardened steel shaft resists cutting or Freon attacks
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Product Description
High Security Steering Wheel Lock with Airbag Protection PlateFor the ultimate in steering wheel security, the FJM Steering Wheel Lock is virtually impossible to defeat. While other steering wheel locks are susceptible to lock picking or can be removed simply by cutting the steering wheel, the FJM Steering Wheel Lock features a pick-proof lock and dual steel hooks that grasp the steering wheel and make it impossible to remove, even after several cuts to the steering wheel.
The FJM Steering Wheel Lock is simple to install and locks into place without a key. The 14mm hexagon shaped hardened steel shaft resists cutting and withstands common Freon attacks used by thieves. The FJM Steering Wheel Lock also includes the patented Pagoda lock system that resists drilling and punching. The FJM Steering Wheel Lock is constructed of heavy duty metal, but is more compact in size and easier to store than other less effective steering wheel locks on the market.
The FJM Steering Wheel Lock can be used with or without the optional Airbag Protection Plate. When used with the FJM Steering Wheel Lock, the metal Airbag Protection Plate prevents airbag theft by covering the steering wheel airbag for added security (stolen airbags have high market value). In addition, the metal plate prevents access to the bolt that secures the steering wheel to the steering wheel column. Some thieves will simply remove the steering wheel and install their own small steering wheel to bypass the steering wheel lock and steel the car.
Best Steering Wheel Lock Features
- Optional Airbag plate fits up to 15"" diameter steering wheel
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Product Detail
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- Shipping Weight: 5.5 pounds
- Item model number: HS7100-SWL
- Average Customer Review: Customer Reviews


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GREENSBORO – North Davidson's girls have long dominated Davidson County swimming and that tradition continued Thursday night inside the Greensboro Aquatic Center at the Greensboro Coliseum Complex.
The Black Knights won five events to capture the 2017 Davidson County Championship swim meet, reeling off the ninth consecutive county title for the North girls.
North coach Brian Wells, jubilant in victory, praised both consistency of his upperclassmen and his squad's depth following their impressive win.
"We swim with consistency and have a lot of depth," Wells said. "When you're scoring 12 places and putting 3 people in the top 12 frequently, it's very helpful."
Wells added, "We have a strong upper class right now with 6 seniors and 10 juniors so we are junior and senior-heavy and have lots of girls that are leaders."
North's Morgan Dennis and Savannah Langley each captured three first place medals helping the heavily favored Black Knights (319 points) cruise past Ledford (231) and East Davidson (173 who finished second and third, respectively.
"Based on the seeding they all performed well and that's what you get from girls that have been here for a while. They know expectations and perform. The girls have won this nine years in a row and the expectations were maintaining that and they kept that going," continued Wells regarding his team's dominating performance.
Dennis (100 and 500 freestyle) was the only North swimmer to win multiple events on the girls side and she also swam the first leg of the girl's 400 freestyle relay which the Black Knights captured by beating a strong East Davidson relay team by two seconds.
After her impressive showing to lead the Black Knights' charge, Dennis reflected on the training efforts that put her in position to win multiple events. "I knew that I had worked hard enough to win so I wanted to just relax and just trust that I had done the work and that I would get good results from it," Dennis said.
Meanwhile, Langley joined Dennis with three first place medals, winning the 200 freestyle by nearly seven seconds over teammate Gracie Leatherman. Langley teamed up with Dennis on the winning 400 freestyle relay team and also was part of the winning 200 freestyle relay squad.
Joining Langley and Dennis on the podium for the 400 freestyle was Leatherman and Maggie Hostetter.
With Katherine White, Eden Cooke and Parker Miller joining Langley on the winning 200 freestyle relay team, North showcased some of the depth Wells spoke about after the meet. In all, seven different swimmers brought home first place medals for North's girls.
Despite finishing behind North and Ledford, it was East Davidson that captured the most first place medals in the girls' championship meet.
The Golden Eagles got two individual wins each from Piper Burton (100 butterfly, 100 breaststroke) and Maggie Whitman (100 backstroke, 50 freestyle) to lead East to a total of six first place medals.
"Lots of practicing and training got me a couple of wins," Burton said after the meet, echoing Dennis' sentiments about training and preparation. "I think I did pretty well for where I am right now because I've put a lot of work in between my club team and here," Burton added.
Ella Whitman's win in the 200 yard IM gave the Eagles a total of five individual wins for the girls. In the 200 medley relay East's Anne Lane teamed up with Burton, Whitman and Whitman to beat the North squad by three-and-a-half seconds for the Eagles' only relay title.
North and East combined to take all 11 first place medals in the girls meet.
Following North, Ledford and East in the girls' team standings was Lexington, finishing fourth with 139 points. West Davidson (131) finished fifth, followed by Oak Grove (107) and Central Davidson (92).


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Thank you for your interest choosing Prestige International Insurance Group for you coverage needs. Please fill out the form below so that we may help you find the best coverage.
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- About
- Watershed Info
- Projects & Programs
- Events
- Dive In
- Donate!
Junior Forest Wardens at the Ambassador Breakfast - June 21, 2013
The June episode of the Watershed Ambassador Breakfast welcomed the Junior Forest Wardens to speak about their experiences in the Red Deer River Watershed.
Youth spokesperson, Zoe Thompson took the stage to share her stories and pictures and gave a heartwarming presentation to a crowd of 30 people. Zoe is a Grade Six Honor Roll student with an affinity for nature. She is most passionate about bears and conservation of their habitat.
Junior Forest Wardens is an outdoor oriented program for young people between the ages of 6-18. Parents are encouraged to participate with their children. The program is committed to providing opportunities to get outdoors through camping, backpacking, canoeing, tree planting and more.
There is also an educational component where Wardens are taught about tree, plant and animal identification, soil types, weather and water.
For more information on the Junior Forest Wardens visit - www.jfwa.ca
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Our Team.
his subcontracting plan describes the FTI approach to subcontract management in support of Seaport-e. It describes the subcontractors that are a part of the team, the roles played by each subcontractor and the subcontract management process. FTI will apply the same management policies and procedures that have made the company successful in working as a prime contractor in other government contractors.
FTI has carefully reviewed the capabilities of the subcontractors that were invited to join its Seaport-e team. The selection process included evaluation of technical breadth and capability, performance risk, customer satisfaction and cost. Potential subcontractors were also evaluated on their corporate management approaches and willingness and ability to work within FTI's proven management approaches and contract cost objectives. They were also reviewed to ensure that they had the accounting, security and personnel management capabilities I place to permit them to function as an effective member of the Seaport-e team.
The subcontractors have been selected based on their ability to complement and enhance FTI's capabilities in each of the proposed functional areas and zones. Each subcontractor is outstanding from a technology and management perspective and can provide staff in numbers and with the requisite skill sets that ensure responsiveness to the Virtual Syscoms and high customer satisfaction. Teaming agreements with each subcontractor are in place and have been submitted with this proposal.
The FTI team consists of two small businesses, Brandes Associates, Inc. (BAI) and Architecture Technology, Corp. (ATC) and three large businesses Accenture Corporation, and Booz Allen Hamilton (BAH).


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Generative Grammar
Language Acquisition
Language and Communication
Language and Culture
Lexical Functional Grammar
Natural Language
Prosody and Intonation
Speech Perception
Speech Recognition
Word Meaning
How Language Comes to Children
That children learn to speak so skillfully at a young age has long fascinated adults. Most children virtually master their native tongue even before learning to tie their shoelaces. The ability to acquire language has historically been regarded as a "gift"—a view given scientific foundation only in the present century by Noam Chomsky's theory of "universal grammar," which posits an innate knowledge of the principles that structure all languages.
In this delightful, accessible book, psycholinguist Bénédicte de Boysson-Bardies presents a broad picture of language development, from fetal development to the toddler years, and examines a wide range of puzzling questions: How do newborns recognize elements of speech? How do they distinguish them from nonspeech sounds? How do they organize and analyze them? How do they ultimately come to understand and reproduce these sounds? Finally, how does the ability to communicate through language emerge in children? Boysson-Bardies also addresses questions of particular interest to parents, such as whether one should speak to children in a special way to facilitate language learning and whether there is cause to worry when a twenty-month-old child does not yet speak. Although the author provides a clear summary of the current state of language acquisition theory, the special appeal of the book lies in her research and "dialogue" with her many young subjects.


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On August 6, 2009 Ngo and Mac were arrested. Their residence was searched and the police found large quantities of drugs and cash. Two days later the police attended another address – which was believed to be a stash house. When the police arrived Yowfoo's car was in the driveway. It was not his residence. About 53 minutes later he emerged carrying two bags (which later were found to contain items consistent with drug trafficking). The police arrested him.
The police then searched the residence and found a locked closet – inside they discovered drugs and firearms – which could have been worth up to $1.7 million. Yowfoo was charged in relation to those items. The evidence at trial included his presence in the house, he had a key for the residence, he had packaging for the brand of lock on the closet, although there was no evidence he had a key for the lock.
Yowfoo was convicted. He appealed: 2013 ONCA 751.
On appeal Yowfoo argued that there was no evidence that he had a key for the lock on the closet and that he left without retrieving the items in the closet. From this, combined with the evidence above, Yowfoo argued that there is a reasonable inference that he attended that residence to clean out the drug trafficking items he was arrested with after having heard that Mac and Ngo were arrested and either had no knowledge or no control over the closet.
The Court of Appeal accepted this as a reasonable inference and overturned the conviction, notwithstanding that Yowfoo did not testify.


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With home security systems without wire, you'll be able to come through technology and home automation standards known as Z-Wave and Zigbee. Just what are Zigbee and Z-Wave and how are these two Home security systems technologies are different . Both Z-Wave and Zibgee are known as mesh networking meaning each node integrated in this system will act as a source of data and wireless repeater as well. The data from one node continue to jump or jump from one node to the next node until it reaches the gateway router. Both Z-Wave and Zigbee are frequently used in the manufacture of wireless home and other things security systems such as HVAC control, home automation and other systems to enterprise security. These networks use the same protocol also known as the low personal rate for a united network physical layer.
ZigBee home security systems is different home security systems Z-Wave as such because it uses the 2.4 GHz frequency band which means that the hardware using, it can be used and installed anywhere in the world. However 2.4 GHz is a busy frequency and can be subject to interference from Bluetooth devices and Wi-Fi. Z-Wave is different because it uses the ISM 915 MHz frequency ban. Z-Wave uses its own radio system made by Sigma Designs has everything Zigbee suppliers for their radio systems. Home security systems with the Z-Wave technology have less hassles of Zigbee interoperability that when it comes to this aspect.


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Olivia Brotheridge Interview
Olivia Brotheridge specialises in colourful illustrated maps, her designs are influenced by the environments around her as well as the physical process of creating. Particularly interested in the stories behind the places, the details in Olivia's maps come from interviews with locals and her experiences at street level. Olivia's skills in printmaking inform her digital imagery; she now thinks in layers, textures and minimal colours, creating all her illustrations by hand before scanning and putting them together.
I'm a hippy at heart - I grew up practicing Transcendental Meditation and I'm a lifelong veggie.
I've always loved art, and, well, I was just drawn to it! I studied Illustration at uni, specialising in printmaking and haven't stopped since. My mum is an art teacher and her parents are both painters, so it's definitely in my blood.
My desire to interpret stories and experiences pushes me to create, I'm always curious and wanting to develop my process and style. I love looking at other printmakers from around the world and seeing how they use colour, texture and overlay. My brilliant creative friends are always inspiring too, if we have a free day we set each other little projects.
Mostly at my desk! I try to work physically as much as possible, with brush and ink or making paper cut stencils. I try to make sure I get out for a bike ride or a walk with a friend so I don't go crazy.
I'm not sure if I've ever had creative block (touch wood), but if I'm really stuck on a creative problem I'll meditate - the answer sometimes seems obvious afterwards.
I recently worked with Burberry on a bag personalisation project, I enjoyed really focusing on hand lettering for that. I've worked with The Big Draw on a number of projects and totally love them and everything they stand for. Most of my maps have been privately commissioned, those clients have been absolutely amazing, trusting me and giving me loads of creative freedom.
For this piece I mixed up my materials to give different textures and marks, mostly painting with black ink, or pencil, using a light box to get the multiple layers and then scanning to colour and build up the image in Photoshop.
Instagram, and a few great artists books that I have.
Work hard and do what you love and it will shine through in your work. Find your niche, build up connections, join the Association of Illustrators who can give advice on building folio and how to approach working professionally as an illustrator. Keep a part time job until you get the ball rolling.
Travel illustration! Getting to visit wonderful places, meet people and draw.
Your walls may like


text: complete sy motor. from intake to oil pan. stock turbo, stock exhaust manifolds, stock downpipe, alternator, ac unit , motor mounts, wiring harness, computer, stock intercooler, heat exchanger, oil cooler. selling complete as listed . if it does not sell it will go into building a clone. approx 1hundred thousand miles, has been sitting for more than 10years. 2500 dollars. can bring to syty carlisle.


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Artist's description:
160x145cm. Large acrylic painting by Costa Rican artist Felix Murillo. Abstract in earthy colors called "So close to me". Features wrap around or finished edges design in order to be displayed without frame. This is a large painting designed to be a center piece in any interior. Shipping depends on the destination. The painting will be shipped in a roll inside a PVC pipe directly from the artist's studio in Costa Rica via DHL Express. Must be mounted or framed by the buyer.
Materials used:
Tan cerca de mi II (2015)
Acrylic painting by Felix Murillo
- Acrylic painting on Canvas
- One of a kind artwork
- Size: 57.09 x 62.99 x 0.79 in (unframed) / 57.09 x 62.99 in (actual image size)
- Signed on the front
- Style: Abstract
- Subject: Landscapes, sea and sky
This artwork is sold by Felix Murillo from Costa Rica


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Microlearning, one of the hottest eLearning trends, is catching attention amongst eLearning fraternity like never before. Our recent discussion on a LinkedIn group received a stream of thoughts and perspectives on microlearning. In this blog, we will discuss the microlearning case study that illustrates how we've developed and delivered microlearning course/application as performance support to reinforce existing training.
Before we could explore the case study, let's first understand what microlearning actually means. "Microlearning is not just bite-sized eLearning content that is chunked to deliver short bursts of information, but it is more than that…"
Source: http://www.swiftelearningservices.com/microlearning-case-study/