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Now, admittedly, my entire campaign thus far is based on one issue, but yesterday while attending a 9-year-old girl's birthday party with my kids, I came up with a second point.
While I strongly support freedom of expression, I also believe some times are better than others to express your beliefs.
So, if elected President, I promise you this:
Any father who shows up at his 9-year daughter's birthday party wearing a T-shirt that says "IT AIN'T GONNA SUCK ITSELF" with an arrow pointing downwards, will be immediately castrated by specially trained fashion police.
Vote Grumpy, 2012!


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Egypt: who's in charge?
Issued on: Modified:
He's Egypt's first civilian president but president of what? François Picard's panel speculate over Mohamed Morsi's ability to claw back prerogatives recently confiscated by the outgoing generals.
- Nader AMRAM. Foreign Relations Committee, Freedom & Justice Party - from Cairo;
- Hanna YOUSEF. Political activist. Member, January 25th Movement in Paris;
- Henri BOULAD. Director, Jesuit Cultural Center in Alexandria. Vice Chairman, Caritas Egypt;
- Gil MIHAELY. Columnist, Yedioth Ahronoth.
Produced by François Picard, Anelise Borges, Mary Colombel, Christopher Davis.


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|Send News. Want a reply? Read this. More in the FAQ. News Forum - All Forums - Mobile - PDA - RSS Headlines Twitter
A post on the Call of Duty Community Website outlines details on PC online security, matchmaking and servers in Call of Duty: Black Ops 2, Treyarch's upcoming military shooter sequel. Here's a handy summary of key points courtesy of One Of Swords, where there's also a discussion of some of the negative backlash this has inspired:
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The Shell Graduate Programme
As a Geophysicists joining the technical area of the Shell Graduate Programme for Geoscience is a technical, three-year blended learning programme. It is a combination of on-the-job development, structured training and fieldwork, designed to introduce you to the full scope of Shell's operations, build your networks and give you a broad foundation for your future career.
You'll be able to apply your skills and be assigned to work as part of a team on a current technical project. During the Shell Graduate Programme you will have the chance to rotate between roles, all the while working closely with senior technical experts.


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Wednesday, January 20
Who Needs Meat When You've Got Hearty Mediterranean Vegetable Stew with Olives?
In my last post I mentioned that when I was a child I felt sorry for kids whose moms made "meat and potatoes" dinners. That was until I heard of moms who were vegetarians. I thought that was tragic.
I think I was about eleven when I discovered vegetarianism from a student teacher who was raising her children to be vegetarians. No hamburgers on the grill? No hot dogs at baseball games? No chicken parm sandwiches on Sunday night? What kind of a mother does that to her children? I wondered. If it weren't for my mom's meatball sandwiches, I don't think I would have made it through middle school.
Then one day several years later, I did the unthinkable. I became a vegetarian; not because I wanted to ruin my children's lives (I don't have children), but because of an unfortunate incident with some tainted chicken. I didn't eat meat for years after that.
I do eat meat now, but I still love vegetarian meals which I eat several times a week. And since I'm featuring one-pot meals this week, I want to share my recipe for Mediterranean Vegetable Stew with Olives. For those of you who wonder whether or not a vegetable stew can be as satisfying as beef stew, I'm telling you, Yes, it can. Since it's loaded with fiber-rich vegetables and high-protein cannelini beans, this vegetable stew is filling yet low-cal and healthy. It's reminiscent of eggplant caponata, but has more layers of flavor since it's got licorice-scented fennel and briny Kalamata and Cerignola olives. I don't have to tell you to sop up the juices with good, crusty Italian bread.
I don't miss the meat in this vegetable stew at all. Of course, I don't plan on giving up my mom's meatball sandwiches. That would be tragic.
Mediterranean Vegetable Stew with Olives
Makes 6 servings
Print recipe only here.
Note: Omit the grated cheese, and this recipe is vegan.
3 tablespoons olive oil
1 yellow onion, diced
3 garlic cloves, minced
1 fennel bulb, cut into ¾-inch pieces (about 1 ½ cups)
1 eggplant, cut into ¾-inch pieces (about 3 ½ cups)
1 red bell pepper, cut into ¾-inch pieces (about 2 cups)
¼ cup dry white wine
1 (28- ounce) can crushed tomatoes
¼ cup coarsely chopped Kalamata olives
¼ cup coarsely chopped Cerignola olives (large, green Italian olives)
1 (14-ounce) can cannellini beans, drained
Zest of ½ lemon (about 1 teaspoon)
1 teaspoon fennel seeds
¼ teaspoon salt
¼ teaspoon crushed red pepper flakes
1 tablespoon finely chopped fresh rosemary
3 tablespoons finely chopped fresh parsley
Grated Parmesan or Reggiano-Parmigiano cheese
1. In a large skillet over medium-high heat, heat oil. Add onions, and sauté until just transparent, about 3 minutes. Add garlic and fennel, and cook 2 minutes. Add eggplant and peppers, and cook 3-4 minutes, or until slightly softened. Add wine, and cook 5 minutes. Add tomatoes. Reduce heat to low, and simmer for 10 minutes, or until vegetables are tender but not mushy. Add olives, cannellini beans, lemon zest, fennel seeds, salt, and crushed red pepper. Stir well, and cook until heated through, 3-4 minutes. Stir in fresh herbs.
2. Serve with crusty Italian bread, or serve atop polenta, rice, or wide pasta noodles, such as parpadelle. Garnish individual servings with desired amount of grated cheese.
You might also enjoy these easy vegetarian meals from Food Blogga:
Thai Pineapple Fried Rice
Warm Bulgur Salad with Beets, Fennel, and Oranges
Rigatoni with Walnut, Parsley, and Sun-Dried Tomato Pesto
Butternut Squash Risotto with Rosemary, Walnuts, and Blue Cheese
Here are more vegetarian one-pot meals you might enjoy:
Spicy Vegetarian Chili recipe at Simply Recipes
Pueblo Vegetable Stew recipe at The Perfect Pantry
Lemony Lentil Vegetable Stew recipe at Mango and Tomato
Chili Piquin Vegetarian Tortilla Soup recipe at The Whole Gang
31 comments:
- Bellini Valli said...
My dad has always been a vegetarian so I grew up with diversity from my moms kitchen. I couldn't give up meat and fish altogether but it's wonderful to balance out our menu with wonderful dishes like this one Susan.
- January 20, 2010 at 6:20 AM
- lisaiscooking said...
I'm definitely a fan of rich vegetarian stews, and this sounds like a great one! The fennel and olives sound delicious in this.
- January 20, 2010 at 6:42 AM
- Megan said...
thanks for this post! I am vegetarian and it seems like most of the great recipes have meat in them!!!
- January 20, 2010 at 7:55 AM
- Rosa's Yummy Yums said...
Nobody ;-P... I love such vegetarian dishes!
- January 20, 2010 at 7:57 AM
- Núria said...
I'm not vegetarian but I adore veggies :D, so your dish sounds perfect now that I want to start a diet... again. Olives give the stew such a different twist.
- January 20, 2010 at 8:18 AM
- Kalyn said...
Oh yes, this sounds amazing. I love olives, could eat them every day.
- January 20, 2010 at 8:18 AM
- T.W. Barritt at Culinary Types said...
Oh, oh, oh!!! I love these kinds of stews, and such a fan of BIG Olive flavor!
- January 20, 2010 at 8:27 AM
- LetMeEatCake Eat With Me! said...
What a great dinner recipe! I can't wait to make it this week, and I love the olives in the stew. I bet it tastes fantastic! Great way to enjoy your veggies =)
- January 20, 2010 at 9:02 AM
- Alanna said...
With foods this 'rich' -- in flavor -- it's easy to forgo meat more and more often! Lovely, Susan --
- January 20, 2010 at 9:08 AM
- intxaurtsu said...
Fantástico!!! y yo espero no aleccionar a mis hij@s y aún menos hacerles unos raritos, pero intentaré enseñarles a comer bien, y más verde que carne.....pero dejaré la elección en sus manos
- January 20, 2010 at 10:05 AM
- MyKitchenInHalfCups said...
No doubt that this would make me so happy, I know I wouldn't miss any meat. Those cannelini beans are some of my favorites.
- January 20, 2010 at 1:04 PM
- Manggy said...
I do enjoy meatless meals every now and again too -- not out of guilt or whatever, but it makes me feel refreshed. Of course I could never do without the occasional steamed pork bun :) This stew would also do a good job of satisfying my hunger pangs!
- January 20, 2010 at 2:03 PM
- Maria said...
I always go meatless:) This stew looks amazing!
- January 20, 2010 at 3:13 PM
- Nicole said...
Sounds so satisfying and I love the addition of olives!
- January 20, 2010 at 3:38 PM
- Susan from Food Blogga said...
val-At least you learned balance, which is really so important for your health.
lisa-I know you love vegetarian meals. :)
megan-This one is meat-less and great. I promise!
rosa-me too!
nuria-That add amazing flavor.
kalyn-Me too! Especially the ones from the local Italian deli.
tw-It's a distinctive flavor.
letmeeatcake-Getting enough veggies in your diet is easy with this stew.
alanna-Thanks so much!
inxaurtsu-Muchos Gracias!
tanna-Aren't cannelini beans the best?
mark-It does make you feel lighter, doesn't it?
maria-It's easy for you!
nicole-I love olives too.
- January 20, 2010 at 3:52 PM
- Kelly said...
That sounds fantastic!! This could be a good superbowl meal for me and my husband!!
- January 20, 2010 at 4:41 PM
- Olga said...
I got a few hits from your blog: and now know why :) Thanks for including my lentil lemony stew!
- January 20, 2010 at 6:18 PM
- Stephanie - Wasabimon.com said...
Dear lord, this looks like a perfect soup for the weather we're having. I hear you all had a tornado in SoCal yesterday! Up here's it raining sideways.
- January 20, 2010 at 6:22 PM
- The Teacher Cooks said...
This sounds delicious! You did make me laugh today. Thank you!
- January 20, 2010 at 6:27 PM
- intxaurtsu said...
uauu...I forgot it was an English written blog!!! The google reader translated it to me, sorry, next time I'll write in English
- January 20, 2010 at 10:31 PM
- Deeba PAB said...
I definitely veer towards vegetarianism, though my kids are horrified at the very idea! I still try to tempt them with veggies!! This is just the perfect stew for this cold spell Susan!
- January 21, 2010 at 5:11 AM
- Judy@nofearentertaining said...
Love this recipe. Think I will make it this weekend...The fennel and the olives sound so good!
- January 21, 2010 at 5:32 AM
- Susan @ SGCC said...
I never even met a vegetarian until we moved to Florida. I remember feeling the same way as you. My mother used to pack meatball subs and sausage and pepper sandwiches in my lunchbox, while all the other kids got peanut butter and jelly. She occasionally broke down and made veggie stews like this, and they were always enjoyed and appreciated. Your stew looks lovely and satisfying!
- January 21, 2010 at 6:00 AM
- Tasty Eats At Home said...
My husband still wrinkles his nose at the idea of vegetarian anything. (He does love my vegetarian chili though...sometimes I can win him over!) I would LOVE this stew - I should make it just for me! (hubby won't be keen on the eggplant. Or olives. Boo.) Sounds so veggie-packed and delicious.
- January 21, 2010 at 6:04 AM
- Kate said...
I've developed LESS of a taste for meat as I've gotten older, but likely it's due to being much more aware of just how fulfilling a meat-less meal can be. Mike and I would go nearly meat-free if it wasn't for the Little Carnivore. We could survive on fish for protein and occasional chicken. Love this stew recipe!
- January 21, 2010 at 7:10 AM
- Cookie baker Lynn said...
It's kind of weird that having a meal without meat makes people ask if you're vegetarian. I'm not, but I'd totally go for that stew!
- January 21, 2010 at 9:12 AM
- Cookie baker Lynn said...
Oh, and there's an award for you to pick up on my blog. :-)
- January 21, 2010 at 9:12 AM
- Susan from Food Blogga said...
kelly-It would make a great Super Bowl dish!
olga-My pleasure!
stephanie-It didn't affect where we are, but, whoa! that was scary.
teachercooks-Glad to hear it. :)
intxaurstu-That's OK. I used Google Translator to read it, but it didn't translate very well. So I just thank you! :)
deeba-That's not too surprising. Kids and hamburgers are a tough couple to break apart.
judy-I hope you do!
susan-OMG, sausage and pepper sandwiches. Mmmm.... Sounds like our mothers were very much alike.
tasteyeats- He doesn't like eggplant or olives? Boo, indeed! ;)
kate-Yeah, I know exactly what you mean. I like the balance.
lynn-Yeah, it is kind of weird, isn't it? I'll be right over. Thanks!
- January 21, 2010 at 7:16 PM
- Johanna GGG said...
sounds like a great stew - I never really appreciated fennel til last year and now I need to find ways to use it - just like this
- January 23, 2010 at 4:57 AM
- Table Talk said...
Love all the briny flavors in this one; and a bright spot with fennel-
- January 26, 2010 at 5:22 AM
Vegetarian stews have lots of fans
including Paul McCartney. Recommended reading for you and your respondents: The Face on Your Plate, by Jeffrey M. Masson.
An education in a book.
- June 7, 2010 at 7:47 AM


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Citizenship in the Community
From MeritBadgeDotOrg
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Revision as of 15:52, February 15, 2019
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|Citizenship in the Community merit badge is required for the Eagle Scout rank.
|Citizenship in the Community merit badge requires prior counselor and/or parent approval for requirement(s) #4b, 5, 7c.
|Citizenship in the Community merit badge
|parts of Citizenship
|BSA Advancement ID:
|Requirements revision:
|Latest pamphlet revision:
|A nation is a patchwork of communities that differ from each other and may be governed differently. But regardless of how local communities differ, they all have one point in common: In the United States, local government means self-government. Good citizens help to make decisions about their community through their elected local officials.
Citizenship in the Community merit badge requirements
View the change list (history) of these requirements. The text of these requirements may be locked. In that case, they can only be edited by an administrator.
Please note any errors found in the above requirements on this article's Talk Page.
- The BSA Citizenship Troop Program Feature offers meeting and activity plans to include Citizenship in the Community as one of your monthly themes.
- Citizenship in the Community is a popular merit badge.
Requirement resources
1. Citizenship - Rights - Duties - Jury Duty - Obligations (Responsibilities)
2a. Google Maps - Make and save a map of your community - Sample Google Map Made By A Scout
3a. Find Information about your county's government
4. Major daily US newspapers
4a. Branches of Government
5. Movies With A Meaning
6. Local Government Services
7a. Charitable Organizations - include "nonprofit groups that are religious, charitable, educational, scientific, or literary in purpose, or that work to prevent cruelty to children or animals."
- Service must be to an organization "outside of Scouting" that "brings people in your community together to work for the good of your community."
- Charitable Organizations "outside of Scouting" might include: Churches, religious organizations, federal, state, and local governments, Salvation Army, Red Cross, CARE, Goodwill Industries, United Way, Boys and Girls Clubs of America, war veteran's groups, fraternal lodges, and nonprofit schools, hospitals, museums, etc.
- IRS online search for charities by name or city
- GuideStar Directory of Non-profit Organizations - find charitable organizations in your area.
- BBB Wise Giving Alliance - list of charities
8. Presentation resources:
- Merit Badges: Public Speaking - Communication
- Speeches & Presentations: How to Choose a topic - How to Write a Speech - How to Give a Speech - Ideas from eHow
- Lesson Videos: ExpertVillage: Giving a Speech - Public Speaking Tips - Eye Contact - Hand Gestures - Props
The Citizenship in the Community #8 public presentation...of your community
could be given as a Communication #3 five-minute speech
using the techniques from Photography #4b to produce a picture story
and Art #1 to tell a story with...pictures
which could be developed into the Digital Technology #6d short presentation.
Related awards
|Personal development-related awards
See also
|General Merit Badge information
External links
- Living in an American Community
- US Community Page Index - more about your city and lots of links, too
Movies With a Meaning
Note: Only watch a movie..."With the approval of your counselor and a parent..."' Please do not add links for anything above a mild PG-13. Please note the ratings and reasons for the ratings for each film.
- 12 Angry Men One man, Henry Fonda, sways a jury and saves an innocent man. NR but would be G today.
- Amazing Grace Chronicles the struggle of William Wilberforce to stop the British slave trade in the late 18th and early 19th centuries. PG for disturbing images of slavery.
- A Man For All Seasons The story of Sir Thomas More who challenged King Henry VIII'sdivorce and remarriage. Rated G.
- America's Godly Heritage Chronicles the faith of the nation's forefathers. Not rated.
- Angels in the Outfield A young boy asks for a miracle to bring his family back together and to have his favorite baseball team win the season. PG.
- Balto Animated story of a dog that leads a sledding team across Alaska in order to get medicine for a sick girl. PG [1:14]
- The Blindside The true story of Michael Oher, a homeless boy who became a first round Baltimore Raven draft pick with the help of a caring woman and her family. PG-13.
- Cars A hot-shot race-car named Lightning McQueen gets waylaid in Radiator Springs, where he finds the true meaning of friendship and family. G
- Fly Away Home An adventure to save orphaned geese. PG.
- Follow Me Boys The story of how one guy starts a Boy Scout troop to help the town. NR.
- Forrest Gump One slow-witted but good-hearted man is at the center of key events of the 20th century. "Stupid is as stupid does." PG-13 for brief sexual content and war scenes.
- Gettysburg Great historical account of Colonel Joshua Chmberlain who held Little Round Top though greatly outnumbered. Out of ammunition, Chamberlain orders a charge instead of retreating. PG for war scenes.
- Gods and Generals Stonewall Jackson and the Battle of Manassas. PG-13 for war scenes.
- The Great Escape WWII POW escape. NR, but some violence.
- Guns of Navarone WWII Allied soldiers attempt to destroy the German big guns. NR. Some violence.
- High Noon A marshall faces a man just released from prison where he was put by the marshall. His own town refuses to help & the odds are high he will not live. NR. Gunfight at the end.
- Hoot Saving a population of endangered owls. PG for mild obscenities.
- Invincible The true story of Vince Papale, a 30-year-old bartender from South Philadelphia who overcame long odds to play for the Philadelphia Eagles. PG.
- It's A Wonderful Life The message in this film is one of courage and sacrifice for the greater good as George Bailey, a man with big ideas about seeing the world, continually forsakes his own desires to do what is right for the town. The second message is that each life important. No matter how insignificant we feel we are, we are all inextricably linked to each other and play an important part in the fabric of one another's lives.
- Luther All about Luther, the father of the Reformation. Rated PG-13 for violence.
- The Man Who Planted Trees A lone shepherd changes the character of an entire valley.
- Mighty Ducks Emilio Estevez stars as a lawyer doing community service who becomes coach to a pee wee hockey team. PG.
- Mr. Holland's Opus A frustrated composer (Richard Dreyfuss) finds fulfillment as a high school music teacher. PG.
- Mr. Smith Goes to Washington One of Jimmy Stewart's signature roles as an idealistic senator caught in the corruption of the political machine. NR.
- October Sky The true story of Homer Hickam, a coal miner's son who was inspired by the first Sputnik launch to take up rocketry. PG.
- One Night with the King The story of Esther. Rated PG for mild violence, suggestion of sensuality.
- Pay It Forward Like some other kids, 12-year-old Trevor McKinney believed in the goodness of human nature. Like many other kids, he was determined to change the world for the better. Unlike most other kids, he succeeded. Rated PG-13 for mature thematic elements.
- Phenomenon - John Travolta is hit by a light and becomes very smart and addicted to learning. PG. 123 minutes.
- The Prince of Egypt Animated story of Moses. Rated PG for violence.
- Remember the Titans The true story of a newly appointed African-American coach and his high school team on their first season as a racially integrated unit. PG.
- Rock and a Heart Place Volunteering never sounded so good.
- Rookie of the Year A twelve year old boy lives every boy's fantasy when he gets to pitch for the Chicago Cubs. PG.
- Rudy True story of a boy who struggles with life in order to realize his dream: to play football for Notre Dame. PG
- Spartacus The slave, Spartacus, leads a revolt against a corrupt Rome. NR.
- The Ten Commandments The story of Moses. NR.
- The Three Musketeers Comedic interpretation of the classic novel.
- We Are Marshall When a plane crash claims the lives of members of the Marshall University football team and some of its fans, the team's new coach and his few surviving players try to keep the football program alive. PG.
First Aid • Citizenship in the Community • Citizenship in the Nation • Citizenship in the World
Camping • Communication • Cooking • Family Life • Personal Fitness • Personal Management
Emergency Preparedness OR Lifesaving • Environmental Science OR Sustainability
Swimming OR Hiking OR Cycling


text:
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13132 Sales Tax Rate
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The estimated sales tax rate for 13132 is 8%.
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State: New York
County: Oswego County, NY
City: Pennellville, NY
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Beautiful slipcover for the IKEA POÄNG Chair cushion in an outdoor aqua blue "Topsail" print by Waverly!
Simply slip this over your existing cushion, for a whole new look.
- One invisible zipper closure
- Same fabric on both sides
- 100% polyester
This listing is for the cover only, cushion not included.
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FULL PRICE ITEMS can be returned or exchanged within 7 days from date of receipt.
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CUSTOM ORDERS with provided fabric, including "Featured Prints" section are not guaranteed for perfect results. Patterns cannot be altered and your order may not come out as expected. Purchase at your own risk. 50% REFUNDS will be issued for acceptable returns, otherwise NO REFUNDS OR EXCHANGE.
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Inspired by true events, Eddie the Eagle is a feel-good story about Michael "Eddie" Edwards (Taron Egerton), an unlikely but courageous British ski-jumper who never stopped believing in himself - even as an entire nation was counting him out. With the help of a rebellious and charismatic coach (played by Hugh Jackman), Eddie takes on the establishment and wins the hearts of sports fans around the world by making an improbable and historic showing at the 1988 Calgary Winter Olympics. From producers of Kingsman: The Secret Service, Eddie the Eagle stars Taron Egerton as Eddie, the loveable underdog with a never say die attitude.
IMDB Rating: 7.6
Release Date: 26 Feb 2016
Genre: Biography, Comedy, Drama
Runtime: 106 min
Actor : Tom Costello, Jo Hartley, Keith Allen, Dickon Tolson
Writers : Sean Macaulay (screenplay), Simon Kelton (screenplay), Simon Kelton (story)
Director : Dexter Fletcher
Language : English, German
Country : UK, USA, Germany


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Outdoor Motion Detectors
Outdoor motion detector alarms are designed to protect the perimeter of your home or business, and most utilize passive infrared (PIR) technology.The outdoor detectors are a bit more sophisticated than your standard indoor motion sensor alarms, but they secure some of the most critical areas of your home. The best time to stop an intruder is before he even has the chance to enter.
Choosing Your Outdoor Motion Detector Alarm
When buying outdoor motion detector alarms, there are certain things you need to consider. For instance, should you go with wired or wireless? You definitely want to have a weatherproof model, given the outdoor environment. Bear in mind, though, that some are built for more rugged conditions than others and are equipped with a better, more durable housing and lens. The motion sensor alarms should also have features to safeguard against false alarms caused by sunlight. When making your selection, you should also consider whether the outdoor motion alarm is easy to install and maintain, and pay attention to the energy efficiency. The most energy-efficient outdoor motion sensor alarm models only operate when movement is detected.
Finding the Ideal Range
Some outdoor motion detector alarms are designed with a stronger detection pattern than others. Be sure to consider the range of the detector when making your purchase. There are some detectors designed to fit specifically with a given home alarm or surveillance system, but then there are some that can easily be added on to any wireless system, effective with any manufacturer's transmitter and receiver.
Finding the Right Location
Before purchasing an outdoor motion detector or motion sensor alarms, you should first figure out how many you need and where you would like to install them. This can be done by looking over your property. Other than the front and back door, you should survey the spots that you think an intruder might try and enter. With a bit of planning and strategy, you can turn your home or business into a virtually impenetrable fortress.
Find Yours Today
Whether you need a single outdoor motion detector or multiple detectors, no matter what the range or capabilities, you can find it all right here at HomeSecurityStore.com. Browse the full selection of motion sensor alarms, and find exactly what you need to enhance your home security system for the 21st century – indoors and out.
Minimal Price: $72.99


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Backpacking Skills
From MeritBadgeDotOrg
Cycling, First Aid, Navigation, Outdoor skills, Scout skills, Swimming, and Wilderness Survival skills.
While the Boy Scout Handbook and Backpacking Merit Badge Pamphlet are your primary resources, the links below can help you learn Backpacking Skills. See the Disclaimers.
- Backpacking Merit badge
- Make Backpacking A Part of Your Troop Program.
- Philmont Scout Ranch
- Skills Instruction and Videos: Backpacking • Campfire Building • Clothing • Cooking • Cycling • First aid • Navigation • Outdoor • Scout skills • Swimming • Wilderness Survival
► This symbol notes many other lesson videos.
- Related topics: First-Aid Skills - Outdoor Skills - Leave No Trace - Navigation - Outdoor Code - Weather Skills - Clothing
► Videos: Buying a Backpack - Long Trip Backpacks - Selecting a Backpack - Selecting a Pack Cover - Picking a Backpack - External Frame - Internal Frame - Picking a Backpack
Backpacking Preparation
► Videos: Backpacking - Planning - REI: Kitchen Checklist - REI: Backpacking for Beginners - How to Condition for a Backpacking Trip
Packing a Backpack
► Videos: How to Pack for One Night - Packing
Reducing Weight
- See Reducing Weight: Backpacks - Backpacking Stoves - Backpacking Food - Backpacking Gear - Water Purification - Clothing - Sleeping Bags - Pads - Tents and other Outdoor_Gear for details about reducing weight in each of those areas.
- REI: Ultralight Checklist - REI: Lightweight Hiking
Backpacking Stoves
► Videos: Backpacking Stove Options - Cooking Gear - REI: Stoves
- Guide to Safe Scouting: Chemical Fuels - Guide to Safe Scouting: Guidelines for Safely Using Chemical Stoves and Lanterns - Guide to Safe Scouting: Fuels and Fire Prevention
Backpacking Food
► Videos: Backpacking Food - Food to Pack on your Short or Long Hiking Trip
Shouldering a Pack
► Videos: How to Wear a Backpack - Wearing a Backpack - Adjusting a Heavy Backpack on Shoulders - Adjusting Backpack Hip Belts - Adjusting Backpack Shoulder Straps - How to Put on a Heavy Backpack
- REI Videos: Backpacks: Adjust the Fit - Backpacking: Find Torso/Hip Size - Backpacks: How to Hoist -
Backpacking Gear
- Also see Tent Types and Footwear.
► Video: Video: Backpacking Gear - Clothing - Food - REI: Tents - Camp Shoes - Boots - Jackets - Pants - Shirts - Sleepwear - Synthetics - Underwear -
- See Outdoor Safety
See also
- Backpacking Merit badge
- Make Backpacking a Part of Your Troop Program.
- Backpacking Merit Badge Pamphlet
- Skills Instruction and Videos: Backpacking • Campfire Building • Clothing • Cooking • Cycling • First aid • Navigation • Outdoor • Scout skills • Swimming • Wilderness Survival
Related awards
- Outdoor Skills Awards
Disclaimer: This information is not intended as a substitute for professional advice, or formal training. Please note that the only materials recommended by the Boy Scouts of America are those found or listed in official BSA materials such as the current Boy Scout Handbook. Backpacking Skills recommendations are constantly being revised. Neither MeritBadge.Org, nor its contributors make any recommendations. See the Guide to Safe Scouting.
- MeritBadge.Org Disclaimer


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NVIDIA announces the GeForce GTX TITAN, saying their new graphics card can make your PC a "gaming supercomputer" in the vein of The World's #1 Open Science Supercomputer. Word is: "Despite being ten times more powerful than its predecessor, the Titan supercomputer takes up the same amount of space and uses the same amount of power. Only GTX TITAN brings this rare combination of raw power and incredible efficiency to PC gaming." There are p/reviews of the new card on AnandTech, Guru3D, Hardware Canucks, Hardware Heaven, Legit Reviews, and Overclockers Club.
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Drawing is a separate kind of art that allows you to portray your feelings and experiences on the canvas. Modern scientists say that it is necessary to draw everything, regardless of talent. We all ever painted. Someone is ordinary flowers, hearts and stars, and someone knows how to convey the beauty of nature and the experience of a person through his portrait through paints. If it were not for eiffel tower drawing, then we probably would not have learned how our ancestors looked.
What is important eiffel tower drawing?
Psychologists say that eiffel tower drawing is not only interesting, but also useful. Since eiffel tower drawing relieves stress, reduces anxiety, helps a person to abstract from all the fuss. Different types of creativity affect the psychological state of a person; therefore, many doctors strongly recommend eiffel tower drawing to people who have suffered a heavy loss or have suffered from criminal acts. The eiffel tower drawing also helps to cope with depression, bad mood, sadness. The eiffel tower drawing process stimulates the brain, helps to concentrate. Many scientists argue that if you are sitting in a boring meeting or lecture, you must take a piece of paper and not hesitate to draw patterns. So you can perceive and remember more information than if you just sat and listened.
How does eiffel tower drawing help to cope with problems?
Some psychologists and scientists have long argued that their problems and desires need to be visualized. They conducted a test and provided an opportunity for people to draw their problems. And it was a surprise that after such therapy, many claimed that their problems were not as big as they thought. On the contrary, in some ways even funny. Also eiffel tower drawing helps to achieve your desires and make your dreams come true. Try to draw what you want and hang a picture near the desktop. The more often it will catch your eye, the more you will try to go towards your goal. So you will certainly succeed.
What if you can not eiffel tower drawing?
Someone by nature is given the ability to eiffel tower drawing beautifully, and someone just enjoys the work of great artists. If you understand that you cannot do anything on your own, then start small. Now there are many colorings for adults. It is also never too late to go to art school and take lessons from masters. Do not be afraid of ridicule. And create for your pleasure.


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Searching for information about Dorris Abel? Then you have reached the right place as USA People Search concentrates on providing information such as address, phone number, and email for people like Dorris Abel. Additionally, with our huge collection of information for people with the last name Abel, you will be able to pinpoint that one individual you are looking for.
We help our users find the right Dorris they are searching for by accumulating all our information under four main headings – name/aliases, age, location and possible relatives. This allows you to scan all the people with the last name Abel below and find the right one. If you find a listing that looks like the Dorris Abel you are searching for, simply click the View Details link to the right of the listing to view all of the details we have on the person.
If you can't locate the Dorris you are looking for, you can try to uncover it again using the search box above. Another spelling variation might help, but also make sure to type in the full name, if you know it. Once you find the accurate Dorris Abel, explore the details page to see all the information we have to offer.
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I have two issues with slow cookers, and both are deal breakers.
First, I resent the fact that if I want my meat browned — and therefore flavourful — I must sear it in another pan before adding it to the slow cooker. And yes, I know that a small number of (typically very expensive) slow cookers do have the ability to sear meat. But the reality is, most of us don't own those. To me, much of the convenience of a slow cooker is the ability to do everything in one pot. If I can't, it's a lot less convenient.
Second, I distrust how evenly they heat. While there are some dishes for which uneven heating — and even a bit of overheating — isn't a major deal (I'm talking to you, chili), most meals aren't that forgiving. I have rendered far too many recipes inedible by misjudging how intense (or not) my slow cooker would cook. I much prefer the precision of my stovetop, which I can tweak to perfection.
It's for these reasons I've recently become enamoured with one of the original slow cookers — the tagine.
At heart, these conical cooking pots from Morocco are similar to a Dutch oven, at least in terms of how they are intended to be used. The base is shallow, similar to a saute pan. This is topped with a cone-shaped lid. The base is heated directly on the stove, giving the cook not only the ability to sear meat, but also to finely tune the temperature. Many tagines are ceramic, but some are cast iron.
Once the ingredients are seared and liquid is added, the lid is placed on the base, the heat is adjusted to maintain a simmer and the cook can walk away. The shape of the lid is designed to allow steam to gather and condense at the top, then drip back down into the food. The result is near flawless slow cooking that results in moist, tender meats.
I usually start by browning onions and garlic in oil, then adding meat and searing that. I dump in the rest of my ingredients, then pop on the lid, lower the heat and walk away for several hours.
So to help usher in spring, I used my tagine to create this recipe for lamb with chickpeas, tomatoes and rosemary. Hugely flavourful and tremendously easy. I keep it lean by trimming away as much fat from the lamb as possible. Don't have a tagine? Use a heavy duty Dutch oven.
Start to finish: 2 1/2 hours (15 minutes active)
Servings: 8
2 tablespoons olive oil
1 large yellow onion, diced
1 head garlic, minced
2 pounds lamb leg or stew meat, trimmed of fat and cut into 1-inch pieces
2 tablespoons chopped fresh rosemary
15-ounce can chopped or diced tomatoes
15-ounce can chickpeas, drained
3/4 cup chicken broth
Salt and ground black pepper
1 lemon, cut into wedges
Chopped fresh parsley, to garnish
Plain Greek yogurt, to serve
In the base of a tagine or large Dutch oven over medium-high, heat the oil. Add the onion and garlic, then saute until tender and lightly browned, about 2 to 3 minutes. Add the lamb and brown on all sides, about 15 minutes.
Stir in the rosemary, tomatoes, chickpeas and broth, then bring to a simmer. Cover, reduce heat to maintain a bare simmer and let cook for 2 hours, or until the lamb is fork tender.
Season with salt and pepper, then divide between serving plates. Squeeze 1 or 2 lemon wedges over each serving, then top with parsley and a dollop of yogurt.
Nutrition information per serving: 300 calories; 110 calories from fat (37 per cent of total calories); 12 g fat (4 g saturated; 0 g trans fats); 75 mg cholesterol; 21 g carbohydrate; 4 g fiber; 2 g sugar; 28 g protein; 510 mg sodium.
J.M. Hirsch is the food editor for The Associated Press. He blogs at http://www.LunchBoxBlues.com and tweets at http://twitter.com/JM_Hirsch


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Back to All Events
Earlier Event: July 12Chamber of Commerce Meeting
Later Event: July 17Library Board Meeting
The Village of Grant Park is located in northeastern Kankakee County in the state of Illinois. The Village was incorporated in 1883. As of the 2010 census, there were 1,331 residents in the Village. Here you'll find a farm community with an excellent school system and community services. Our various businesses and community events will give you plenty of reasons to visit our little piece of the world.
106 W. Taylor Street
PO Box 446
Grant Park, IL 60940
Phone 815-465-6531
Fax 815-465-6611
Email: firstname.lastname@example.com
Village Hall Hours
M-F 8am-4:30pm
Saturday- Closed
Sunday- Closed
Please call the Grant Park Police Department's non-emergency phone, 815-465-2131, if a problem arises when Village Hall is closed.


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The fact that Düsseldorf, North Rhine-Westphalia's region capital, has an art museum of international renown today is thanks to the former Elector Palatine Johann Wilhelm II, who began to build an art gallery here in 1710. A generous patron, he was able to bring numerous artists to the court and transformed the city into a European centre for art. Although the Kunstpalast Museum itself was only founded in 1913, it would not be what it is today had the Elector not been such a passionate collector of art.
The museum underwent two major renovations to reach its current form – from 1925 to 1926 to plans by architect Wilhelm Kreis and in 1999/2000 to plans by Oswald Mathias Ungers. The building now provides an exceptional setting for its painting collection, which focuses on Old Masters, paintings of the 19th century and the modern age and paintings and sculptures from the Middle Ages to the present day. These works are complemented by arts and crafts, design, graphic art and a renowned glass collection. Among the collection's masterpieces are 'The Ill-matched Pair' by Lucas Cranach the Elder, 'Landscape with Tobias and the Angel' by Jan van Scorel, 'Flight into Egypt' and the famous 'Cross on the Mountain' by Caspar David Friedrich. The section on Modernism features important works from the early 20th century by Paula Modersohn-Becker, Wassily Kandinsky, Walter Ophey, Franz Marc, August Macke, Otto Dix, Emil Nolde and Ernst Ludwig Kirchner.
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It appears that SpaceX's success with the Dragon spacecraft has won some much-needed space in the US House of Representatives. Congressman Frank Wolf (R-VA) announced Tuesday that his office reached a truce with NASA regarding the Commercial Crew program. Under the agreement, Wolf will lower his opposition to Commercial Crew and hopefully help NASA gain better funding.
Wolf chairs the House Appropriations Subcommittee on Commerce, Justice, Science and Related Agencies, which controls NASA's budget. His subcommittee has consistently hit the Commercial Crew Development program (CCDev) with heavy cuts. NASA Administrator Bolden has stated that the cuts have delayed access to the Space Station by American vehicles by at least a year, with this year's cuts expected to delay American access again. In hearings, some of Wolf's subcommittee members have seemed intent on using the coming Space Launch System (SLS) to ferry astronauts to the Space Station, even though this service would come at a price that's about ten times higher.
In April, Wolf included language in the 2013 spending bill's accompanying report that stopped just short of requiring NASA to drop its Commercial Crew competition. Wolf wanted NASA to immediately downsize the program from the current four competitors to either a single "competitor" or a well-funded leader and a weakly funded follower. Commercial space backers have worried that the language would succeed in essentially discontinuing CCDev, given that similar tactics have been used in the Senate.
One fear was that new commercial space companies would be swept away and the job of ferrying astronauts would be given to Boeing, one of the two traditional contractors. The other usual contractor, Lockheed-Martin, is already signed on for NASA's Orion spacecraft. Because the US government is still the only major customer for ferrying humans to orbit, development of a more competitive space industry could be severely curtailed.
On the other hand, support for the newcomers in the commercial space industry has been growing. The topsy-turvy situation, in which Democrats support a new private space industry and Republicans fiercely oppose it, has been questioned on the Republican side, and the recent berthing of the first commercial space capsule with the International Space Station appears to have finally turned the tide. Several members of Wolf's subcommittee who were recalcitrant before the Dragon mission have since made positive announcements. With more tests and launches coming later in the year, Wolf appears to have cut a deal before sentiments shifted again.
Wolf's announcement suggests a compromise agreement wherein Wolf will basically back off of his report's language in return for NASA agreeing to chop CCDev down to two-and-a-half funded competitors (two full awards and one partial award) rather than four. Wolf would back a NASA budget that more closely matched the current Senate funding level, which is slightly more than what his committee recommended on the House side. More importantly, he would not push for language in the new law to require the downselect to a single launch provider.
Other requirements of the agreement, laid out in a letter from Wolf to Bolden, include the following:
- 2013 will be the last year of Commercial Crew general development funding, and any continuing contracts must be made under traditional Federal Acquisition Regulations (FARs). NASA has been using Space Act Agreements to fund the competitors in order to save money. SAAs don't require NASA to be embedded in the contractor and therefore cut costs by at least half.
- NASA will define a strategy for moving to FARs and communicate it to Wolf's office.
- NASA will collect a host of financial and management information on its Commercial Crew partners to verify their ability to complete their contracts.
- NASA will require compliance with statutory and regulatory controls on export of anything developed under the Commercial Crew program.
All of this language is somewhat strange because NASA is already doing most of this. Because Congress chopped its 2013 budget request for CCDev again this year, it seemed likely that NASA would not be able to sustain four competitors anyway. The agency had also announced that it would be transitioning to FARS for general acquisitions, and it already collects financial information on the four competitors. And export controls already prevent shipping of any kind of rocket technology overseas. Accordingly, it doesn't seem like Wolf is really getting anything new.
Wolf's office also provided a link to a letter Administrator Bolden wrote in reply, thanking him for his trust. In the letter, Bolden stipulates that if Wolf wants American vehicles taking astronauts to the International Space Station sooner, the funding Wolf's committee cut from NASA's budget request needs to be restored.
That could actually happen. It's entirely possible that NASA's budget bill will be punted to next year because of the elections, and Congress will pass a continuing resolution instead. In a longshot scenario, additional money would be added to that bill if enough support is present in Congress to get it done. Whether or not the funding is restored, it does seem that SpaceX's victory is yielding some tangible political payoffs for NASA as well.


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I was tossing up being strict and saying that you'll have to return to town or rest up somewhere at your own peril for 8 hours, but now i'm reconsidering. I don't think I want you to just be able to recharge instantly after every battle, but running back to town non-stop could get tedious :pLet me see...How about this: To recharge your spells, you need an hour of rest, plus an hour of study, so two hours of pausing to fill up your spell reserves. This way, you can't just throw spells around willy-nilly, but you're not left with a squishy wizard once your spells are drained. You must decide whether it's worth stopping the group to rest up, or just soldiering on. Also, resting may or may not have repercussions; there could be interruptions, and it potentially gives dungeon dwellers time to move around and such (They may also notice signs of you).Other spellcasters will have the same spell recharging rules.How's that sound?Also, regarding languages; Each of the races will have their own language, and there will be common, which everyone will know - I haven't thought too much on languages though. So lets say there's languages for each classic race (such as Dwarf, Elf, Gnome etc.) and then there's languages for each area (Quinnix (Ouzquin Dremorix), Rabble (Sen-Rab) and Ralkharan. There's also Esgol, which will be the language of the Dwarves of Esgoloth, a high-altitude, mountainous frozen region north of the Desert and Ralkhara.)Don't sweat the small stuff, this world's a work in progress, and it will be expanded as the game progresses, hopefully!
Moruz: Fighter lvl 1 - Standing OrdersNormal: Moruz will attempt to perform Power Attacks with his Melee Weapon.Low HP: Moruz will either fight defensively, or retreat to range and attempt to use his crossbow.Special: If someone else has low HP, Moruz will try and attack and distract whoever is attacking that person.
Goss: I was half-considering making you take some Handle 'Animal' checks to keep the baby under control in some situations - I may still do that! A baby is probably the last thing you want when you're trying to be sneaky!
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An acclaimed poet will this week receive the Ruth Lilly Poetry Prize for her work, which includes an award-wining series about a boy who lives in a housing project
By Janice Harayda
When Lucille Clifton was growing up, her father told her stories about her African great-great-grandmother who was forced into slavery. A sharp awareness of her heritage stayed with her and inspired a memoir, Generations (Random House, 1976). But Clifton may be best known as the author of an award-winning picture-book series that uses rhymed iambic pentameter to tell the story of a sensitive boy named Everett Anderson, who lives in a housing project with his mother.
"I wanted to write about a little boy who was poor and someone who, although he had no things, was not poor in spirit," she said in an interview with Mickey Pearlman in Listen to Their Voices (Houghton Mifflin, 1993). "He's full of love, and he and his mother live well together."
Perhaps the most admired "Everett" book is Everett Anderson's Goodbye (Holt, 1988, paperback), illustrated by Ann Grifalconi, a Reading Rainbow selection and winner of the Coretta Scott King Award from the American Library Association. Everett struggles in this final installment to accept his father's death and realizes that " … whatever happens when people die, / love doesn't stop, and / neither will I."
On Wednesday Clifton will receive this year's $100,000 Ruth Lilly Poetry Prize from the Poetry Foundation www.poetryfoundation.org, which has more about the award on its site. The foundation said in announcing the prize:
"Widely admired since Langston Hughes championed her work in an early anthology of African-American poetry, Clifton has become one of the most significant and beloved American poets of the past quarter century. She writes with great clarity and feeling about family, death, birth, civil rights, and religion, her moral intelligence struggling always to make sense of the lives and relationships to which she is connected, whether those of her immediate family, her African ancestry, or victims of war and prejudice."
© 2007 Janice Harayda. All rights reserved.


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Merton Silver Roman Blind
Product is Discontinued
We are very sorry but this product has been discontinued. This means that we are no longer able to supply this product.
Please take a look at the other products we have on offer. We have a large collection able to satisfy any taste or decor.
Should you want any advice contact us, our friendly customer service team are available.
With over 10 years experience hand crafting Roman blinds for our customers, we know you'll love them as much as we do.
How to measure roman blinds
Quick Measuring Guide
To make sure you get everything perfect, we have put together this video guide to help you get your measurements just right. It's simple, easy, and will make your new blinds look flawless.
- Exact vs. Recess
- Easy, step by step instructions
- Top tips to ensure you measure correctly
Measuring and Installation Guide
Ensure your new blinds are the perfect size for your window with our simple measuring guide. With just a minute or two of your time and a tape measure, you can find out the perfect sized blind for your window.
We've spent years developing our products and are confident in the long term value they bring - we want you to feel the same. That's why we offer an industry leading 5 year guarantee on all of our products. Read the small print here.
With over 10 years experience hand crafting Roman blinds for our customers, we know you'll love them as much as we do.
|51% Polyester, 49% Cotton
|Available Widths
|35cm to 250cm
|Available Drops
|35cm to 250cm
|Fabric Width
|139 cm
|Pattern Repeat
|32 cm
- Fully made to measure to your specifications in our UK factory – perfect every time!
- Free upgrade to Deluxe Headrail with endless sidewinder for easy operation and smooth folds.
- Fully lined as standard, with cost effective upgrades to blackout and thermal lining.
- Fabric panel on headrail can be easily removed for cleaning.
- Choice of position controls on the left or the right.
- Easy to use brackets suitable for top or face fixing.
These blinds are made to measure and have a variety of options. To find more information on an option click the ? next to the selection.
|Chain Colour
|White (plastic), Steel, Brass
|Recess or Exact
|Recess, Exact
|Premium Lining, No Lining, White Blackout Lining, Ivory Blackout Lining, Thermal Lining, Interlined
|Side of Controls
|Left, Right
Measuring Guide
Please click here to view the measuring guide for this product.
Fitting Guides
All of our blinds come with the fixtures and fittings you'll need to install your blind in addition to a set of fitting instructions. You can also download your fitting instructions below.
Measuring Guide Video
Fitting Guide Video
Product Images
Product images are for illustration purposes only. While we endeavour to provide the best representation possible, we always ask that you request a free sample before your purchase.
Made to measure blinds
A product which requires the exact width to be typed in the box is 'Made-to-Measure' and cannot be returned under our normal terms and conditions.
Fabric Join
If the width of your roman blind is wider than the manufacturers fabric width (shown within Details tab) then we will need to make symetrical joins at each side of the blind. If this is the case we will take extreme care to ensure the patterns are correctly aligned.
Free UK Mainland delivery for orders over £149.00. For orders under £149.00 we only charge £7.95 for UK Mainland delivery.
International delivery is available, the price will be calculated during the checkout process.
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Music in the Courtyard
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According to the survey, 90 percent of firms surveyed agreed that if a potential production worker has the right attitude and basic skills, they are willing and able to train them.


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Gene Therapy-Treated Stem Cells in Treating Patients Undergoing Stem Cell Transplant for Intermediate-Grade or High-Grade AIDS-Related Lymphoma
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00569985
Recruitment Status : Active, not recruiting
First Posted : December 10, 2007
Last Update Posted : August 16, 2018
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Biological: lentivirus vector rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells Drug: carmustine Drug: cyclophosphamide Drug: etoposide Procedure: autologous hematopoietic stem cell transplantation
|Phase 1
I. To determine the safety and feasibility of using lentivirus-transduced hematopoietic progenitor cells (HPCs) (lentivirus vector rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells) in the setting of autologous hematopoietic cell transplantation (HCT) for treatment of AIDS related lymphoma. The safety of the of the genetically modified product used in the transplant procedure will be assessed by monitoring each subject for adverse events (procedure related toxicity); absolute neutrophil count (ANC)/platelet engraftment (sustained recovery); and evidence of replication competent vector or vector recombination with the human immunodeficiency virus (HIV) quasi-species present in the patient.
II. To determine the quantity and duration of vector-marked peripheral blood cells and to characterize: the duration and level of gene marking and expression of the anti-HIV ribonucleic acids (RNAs) in these transduced cells, and the characterization of the integration sites of vector sequences in circulating cells if there is a clinical syndrome suggestive of a clonal expansion of hematopoietic cells. In addition, the feasibility of the process will be assessed based on the results of the release testing of the transduced cells prior to injection into the patient.
III. To determine whether the design of the vector prevents vector mobilization and rescue by wild-type HIV-1. IV. To measure the effect of HIV infection on the presence of HIV-resistant blood cells as measured by genetic marking for vector sequences before and after antiviral treatment interruption.
CONDITIONING: Patients receive carmustine intravenously (IV) over 1-2 hours on days -7 to -5, etoposide IV over 4 hours on day -4, and cyclophosphamide IV on day -2.
TRANSPLANTATION: Patients undergo autologous hematopoietic stem cell transplantation comprising lentivirus vector rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells and non-bound cluster of differentiation (CD)34+ cells IV on day 0. After completion of study treatment, patients are followed up every 2 weeks for 3 months; at 4, 6, 8, 10, 12, 18, and 24 months; every 6 months for 3 years; and then annually for 10 years.
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|10 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Pilot Study of Safety and Feasibility of Stem Cell Therapy for Aids Lymphoma Using Stem Cells Treated With a Lentivirus Vector-Encoding Multiple Anti-HIV RNAs
|Study Start Date :
|June 2007
|Estimated Primary Completion Date :
|July 2019
|Estimated Study Completion Date :
|July 2019
Experimental: Treatment (autologous HCT)
CONDITIONING: Patients receive carmustine IV over 1-2 hours on days -7 to -5, etoposide IV over 4 hours on day -4, and cyclophosphamide IV on day -2. TRANSPLANTATION: Patients undergo autologous hematopoietic stem cell transplantation comprising lentivirus vector rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells and non-bound CD34+ cells IV on day 0.
Biological: lentivirus vector rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells
Undergo autologous hematopoietic stem cell transplantation comprising lentivirus vector rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells and non-bound CD34+ cells
Other Name: lentivirus-transduced hematopoietic progenitor cells
Drug: carmustine
Given IV
Other Names:
Drug: cyclophosphamide
Given IV
Other Names:
Drug: etoposide
Given IV
Other Names:
Procedure: autologous hematopoietic stem cell transplantation
Undergo autologous hematopoietic stem cell transplantation comprising lentivirus vector rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells and non-bound CD34+ cells
- Safety of treatment using the National Cancer Institute (NCI) hematologic Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 [ Time Frame: 15 years post stem cell infusion ]The toxicities observed after each stem cell infusion will be summarized in terms of type (organ affected or laboratory determination such as ANC), severity (by NCI CTCAE version 3 and nadir or maximum values for the laboratory measures), time of onset (i.e., course number), duration, and reversibility of outcome. Tables will be created to summarize these toxicities and side effects by dose and by course.
- Survival of shI-TAR-CCR5RZ-marked cells in the peripheral blood, demonstrated by presence of transgene by Q-PCR using primers specific for rHIV7-shI-TAR-CCR5RZ in serial samples of peripheral blood [ Time Frame: 24 months post stem cell infusion ]
- Determination of RNA transgene expression in samples of peripheral blood mononuclear cells (PBMCs) or marrow before and after infusion, analyzed by Northern blotting/hybridization [ Time Frame: Day 1 post stem cell infusion ]For detection of the shRNA, we will use a quantitative real-time PCR assay.
- Analysis of vector rescue by HIV [ Time Frame: 15 years post stem cell infusion ]Integration analysis will be performed only if there is a clinical syndrome that suggests clonal expansion of hematopoietic cells. In that situation, the method of insertion site location will use a linear amplification mediated (LAM)-PCR technique. If positive vector sequences are found in the plasma, confirmation of vector rescue will be done by isolation of HIV and subsequent HIV sequencing.
- Ability to obtain suitable numbers of lentiviral vector treated HPC-A [ Time Frame: Day 2 post apheresis ]The number and type of cells will be determined by fluorescence-activated cell sorting (FACS) analysis of the final cell product. Target number for untransduced cells in the final therapeutic cell product is 2.5 x 10^6 CD34+ cells/kg. Minimum target number of CD34+ cells for transduction is 5 x 10^6/kg and in the final transduced cell product, the number of CD34+ cells must be >= 2.0 x 10^6 CD34+ cells/kg with total viability >= 70%. The relative or absolute number of transduced CD34+ cells will be determined.
- Determination of replication competent lentivirus (RCL) and HIV-1/vector recombination [ Time Frame: 15 years post stem cell infusion ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 60 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- HIV seropositive at or before the time of lymphoma diagnosis
- Anti-HIV chemotherapy; subjects must be on a multi-drug regimen (excluding azidothymidine) and have an HIV viral load < 50,000 copies/ml by reverse transcriptase-polymerase chain reaction (RT-PCR) at the time of study enrollment
- Subjects must agree to have their anti-HIV regimen temporarily stopped, and then all subjects will stop antiretroviral therapy (ART) for approximately 7 days at the time they start filgrastim (G-CSF) post-chemotherapy for peripheral blood progenitor cell (PBPC) mobilization and until the mobilization is complete; in addition, if/when the CD4 counts return to a level of 450/mm^3 with undetectable HIV levels in blood, the subjects will undergo an analytic treatment interruption for an indefinite period not to exceed 6 months
- Karnofsky performance status >= 70%
- Biopsy proven intermediate grade or high-grade non-Hodgkin's lymphoma, including plasmablastic lymphoma, primary effusion lymphoma, or biopsy-proven Hodgkin's lymphoma (entities as defined in the World Health Organization [WHO] classification); tissue histology will be reviewed at the City of Hope; patients with prior marrow involvement must demonstrate =< 10% involvement pre-stem cell collection
- No psychosocial conditions that would hinder study compliance and follow-up
- Pretreatment serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) =< 2.5 x institutional upper limit of normal (ULN)
- Serum bilirubin =< 2.5 x institutional ULN
- Patients who are hepatitis C virus (HCV) antibody positive or hepatitis B virus (HBV) surface antigen positive must be free of clinical evidence of cirrhosis that would otherwise make them ineligible for HCT, as determined by the Principal Investigator (PI) in consultation with the Gastrointestinal Service at City of Hope; patients with HBV and ongoing evidence of viral replication may require therapy prior to receiving high-dose chemotherapy
- Serum creatinine =< 2 x institutional ULN and a 24 hour urine creatinine clearance >= 60 cc/min
- Prothrombin time (PT)/partial thromboplastin time (PTT) =< 2 x normal
- Forced expiratory volume in 1 second (FEV1) or diffusion capacity of the lung for carbon monoxide (DLCO) >= 50% predicted
- Left ventricular ejection fraction (LVEF) >= 50% (by 2-dimensional [2-D] echocardiogram or multigated acquisition scan [MUGA]); absence of cardiomyopathy, congestive heart failure or dysrhythmia
- If the subject is female and of child-bearing potential, subject must have negative serum or urine pregnancy test within 7 days of treatment with research agent; men with partners of child-bearing potential and women of child-bearing potential, must be willing to use medically effective birth control methods, e.g. contraceptive pill, condom, or diaphragm and continue this for one year post HCT
- Subjects must be on a prophylactic regimen for Pneumocystis carinii pneumonia, or agree to begin such treatment, if the CD4 counts are =< 200
ELIGIBILITY CRITERIA (HODGKIN LYMPHOMA) - First or greater relapse after initial complete remission; or partial remission; or induction failure that responds to salvage therapy with stable disease, partial remission, or complete remission (i.e. chemosensitive disease)
- First complete remission with high risk features as specified by the International Prognostic Index, or Relapse after prior complete remission; partial remission; or induction failure that responds to salvage therapy with stable disease, partial remission, or complete remission (i.e. chemosensitive disease)
- Subjects must complete both the therapeutic and research phases of the G-CSF mobilization of peripheral blood progenitor cells and
- Subjects must have collected at least 5 x 10^6 CD34+ cells/kg for the research phase of the collections
Exclusion Criteria:
- Presence of detectible HIV-1 that has C-X-C chemokine receptor type 4 (CXCR4)-tropism
- Any symptomatic bacteria or fungal infection
- AIDS related opportunistic infections within the past year for which treatment has been unsuccessful would be considered exclusionary but on a case-by-case basis as determined by the PI
- Active cytomegalovirus (CMV) retinitis or other active CMV-related organ dysfunction; patients with a history of treated CMV infection are not excluded
- Relapse of Pneumocystis carinii pneumonia within the past year
- Intractable and severe diarrhea, defined as > 1500 cc diarrheal fluid per day, or diarrhea causing persistent severe electrolyte abnormalities or hypoalbuminemia
- Other AIDS-related syndromes, infectious or otherwise, if perceived to cause excessive risk for morbidity post-HCT, as determined by the PI
- History of grade III hemorrhagic cystitis due to prior cyclophosphamide chemotherapy
- Pregnant or nursing women
- Any prior malignancy, except those treated with curative intent that are five years from treatment or cervical and anal squamous cell cancers or superficial basal cell and squamous cell cancers of skin
- Active central nervous system (CNS) lymphoma; patients with a history of positive cerebrospinal fluid cytology that has become negative with intrathecal chemotherapy are eligible
- Abnormal cytogenetics not related to the lymphoma
- History of myocardial infarction or congestive heart failure
- Any history of HIV-associated encephalopathy; dementia of any kind; seizures in the past 12 months; any perceived inability to directly provide informed consent (note: consent may not be obtained by means of a legal guardian)
- Any medical or physical contraindication or other inability to undergo HPC-apheresis (HPC-A) collection
- Elevated amylase or lipase SGOT, SGPT > 2.5 x the institutional ULN
- Serum bilirubin > 2.5 x ULN
- Any other laboratory value for complete blood count (CBC) and chemistry panel > 2 x ULN
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00569985
|United States, California
|City of Hope Medical Center
|Duarte, California, United States, 91010-3000
|Study Chair:
|Amrita Y. Krishnan, MD
|City of Hope Medical Center
|Responsible Party:
|City of Hope Medical Center
|ClinicalTrials.gov Identifier:
|NCT00569985 History of Changes
|Other Study ID Numbers:
NCI-2012-00437 ( Registry Identifier: NCI CTRP )
04047 ( Other Identifier: City of Hope Medical Center )
|First Posted:
|December 10, 2007 Key Record Dates
|Last Update Posted:
|August 16, 2018
|Last Verified:
|August 2018
AIDS-related diffuse large cell lymphoma
AIDS-related diffuse mixed cell lymphoma
AIDS-related diffuse small cleaved cell lymphoma
AIDS-related immunoblastic large cell lymphoma
AIDS-related small noncleaved cell lymphoma
HIV-associated Hodgkin lymphoma
Treatment Experienced
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Etoposide phosphate
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Antirheumatic Agents
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Myeloablative Agonists
Antineoplastic Agents, Phytogenic
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors


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