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Breast cancer enzyme may slow tumour growth
"Cancer cell enzymes shown to act as 'good cops'," is the headline on the BBC News website. The BBC reports on laboratory research into an enzyme called MMP-8 and its effects on breast cancer. The research reveals that while MMP-8 appears to stimulate the growth of breast cancer cells in the short-term, it may slow tumour growth in the long-term. Scientists are likely to want to explore new treatments that use MMP-8's ability to slow tumour growth in this way. However, this study used laboratory-grown cells, which don't behave in the same way as tumour cells within the body. It could be the case that the effect of MMP-8 is different when studied in people. Nonetheless, this research provides new understanding about how the MMP-8 enzyme influences the growth and development of laboratory-grown breast cancer cells. And while this research has limited immediate implications for people with breast cancer it does contribute new understanding that may help to treat the disease in the future. Where did the story come from?The study was carried out by researchers from the University of East Anglia (UK) and the University of Vermont College of Medicine (USA) and was funded by Breast Cancer Campaign, Cancer Research UK, the European Union Framework Programmes 6 and local Norfolk fundraisers. The study was published in the Journal of Biological Chemistry, a peer-reviewed science journal. It was published as an open-access article so it is free to download. The reporting of the research was mixed. While the Mail Online exaggerated the results of the study by describing a "breakthrough" that "turns previous thinking on its head", the BBC coverage was more restrained, including comment from Cancer Research UK on how the research provides "very early clues" about how the enzyme might recruit cells to fight breast cancer. What kind of research was this?This was a laboratory study exploring the role of an enzyme called matrix metalloproteinase-8 (MMP-8) in the growth of breast cancer tumour cells. MMP-8 performs many essential jobs in a normal cell. The researchers say it is known to activate certain immune system signals (called interleukin-6 and interleukin-8), which are types of molecules that regulate and orchestrate the actions of the immune system. The researchers comment that, traditionally, scientists thought MMP-8 helped cancer cells grow and spread, but more recent research has suggested it may also prevent cancer cell growth. This research sought to find out if, and how, MMP-8 inhibited tumour cell growth in laboratory-grown breast cancer cells. Understanding the biology and chemistry of processes involved in diseases such as cancer through laboratory studies is essential if we want to discover new ways to prevent and treat them. What did the research involve?The researchers grew human breast cancer tumour cells in a laboratory. Some cancer cells were deliberately engineered to lack a properly functioning MMP-8 enzyme (called "mutant MMP-8"), whereas others had a fully functional version (known as the "wild-type" version). The intention was to see what effect this had on the ability of the cancer cells to grow and develop. The researchers paid particular attention to the effect of this manipulation on the immune system signalling molecules interleukin-6 (IL-6) and IL-8, which are known to be involved in the growth and development of cancer cells. Genetic changes within the cells were also measured. All the research was carried out in artificially grown laboratory cells and no tests were done in people with cancer. What were the basic results?The research found tumour cells containing the wild-type MMP-8 had elevated levels of IL-6 and IL-8 and that, in the short-term, this was associated with higher levels of tumour cell growth. Cells lacking a working MMP-8 enzyme had lower levels of IL-6 and IL-8 and did not grow as well. However, in the longer term, activity of the MMP-8 enzyme was found to inhibit the growth of the tumour cells and it was found that the IL-6 and IL-8 levels were no longer elevated. Interestingly, the small number of cells with a working MMP-8 enzyme that did keep on growing in the long-term had somehow maintained their elevated levels of IL-6 and IL-8 but these were no longer dependent on MMP-8 activity. The relationship had changed from the short- to the long-term. This showed that in the early stages of tumour growth MMP-8 activity stimulated IL-6 and IL-8, which helped the tumour grow, but, later on, MMP-8 activity limited tumour growth and the IL-6 and IL-8 levels returned to normal. Only cancer cells where MMP-8 activity had become disconnected from IL-6 and IL-8 levels were able to keep growing in the longer term. How did the researchers interpret the results?The researchers concluded that their research showed a "causal connection" between "MMP-8 activity and the IL-6/IL-8 network", which showed MMP-8 influences the signalling of pro-inflammatory factors (IL-6 and IL-8) that "conventionally promote tumour cells' growth and development". ConclusionThis laboratory study provides new understanding about how the MMP-8 enzyme interacts with inflammatory signals (IL-6 and IL-8). MMP-8 might be something of a double-edged sword. While it stimulates the growth of cancerous cells in the short-term, it may also suppress growth in the long-term. As with all laboratory studies, new or different discoveries need to be replicated by other research groups to ensure they are accurate and the results weren't due to chance. Assuming the research results are valid they could provide an opportunity for cancer researchers to investigate and possibly devise new methods of using MMP-8 activity to supress breast tumour cell growth. However, the research found that some tumour cells kept growing despite the presence of MMP-8. This highlights that cancer cells differ, and that, often, what works in one place and setting may not work in others. It is important to remember that the researchers investigated breast cancer cells only, so this study alone does not tell us anything about the role of MMP-8 in other cancer types. Similarly, the research used artificially grown breast cancer cells, which may not behave in exactly the same way as tumour cells within a human body. This research into a new target for drug development provides new and interesting understanding that other researchers can build on. An improved understanding of the biology underpinning breast cancer may lead to the development of new treatments. Analysis by Bazian. Edited by NHS Choices. Follow Behind the Headlines on Twitter. Links To The HeadlinesCancer cell enzymes shown to act as 'good cops'. BBC News, May 24 2013 Breast cancer cells can suppress tumour growth 'by releasing protective proteins'. Mail Online, May 24 2013 Links To ScienceThirkettle S, Decock J, Arnold H, et al. Matrix metalloproteinase-8 (collagenase-2) induces the expression of interleukins-6 and -8 in breast cancer cells. The Journal of Biological Chemistry. Published online May 30 2013 Could open plan offices be bad for your health?
Open plan offices make employees "less productive, less happy, and more likely to get sick" reports the Mail Online website. The article is actually based on a number of studies, but the one we found most interesting was a national survey from 2011, conducted in Denmark, looking at self-reported sick days of open plan workers compared to individual office workers. The study found that people working in an enclosed office space reported lower levels of sickness compared to those working in an open office. Theories offered by the researchers as to why this may be the case, include:
Still, as the researchers themselves point out, this type of study cannot prove either theory. A limitation of the study is that it relied on self-reporting. People were asked to remember and estimate the number of sick days they had over the past year. So participants could have consistently over or underestimated the time off they'd taken, depending on their circumstances. If you do think that your place of work may be impacting on your health, visit the NHS Choices Workplace health section for advice on useful steps you can take. Where did the story come from?The study was carried out by researchers from Denmark and was funded by the Danish Ministry of Employment and the Danish Working Environment Research Fund. The study was published in the peer-reviewed Scandinavian Journal of Work, Environment and Health. The Mail Online's reporting was generally accurate on the study in question. The website also discussed evidence from other studies looking at the impact of open plan offices on stress levels, productivity and health. We cannot comment on the accuracy of the reporting of these others studies as we have not looked at them. What kind of research was this?This was a cross-sectional study aiming to find out whether shared and open plan offices are associated with more days off sick than cellular offices comprising one occupant. A cross-sectional study is a good way of assessing a situation at one point in time, or asking people to recall their recent experiences. The main weakness of this study type is that it cannot establish cause and effect, for example, whether open plan offices cause people to be off sick more often or whether people who are generally of sick more often tend to work in open plan offices. The method also struggles when it involves asking people to recall events of interest from the past, which can be prone to error or bias – specifically recall bias. It could be the case that people are more likely to recall being genuinely sick with the flu than when they decided to "pull a sickie" because they fancied a lie-in in bed. What did the research involve?The research involved a subset of the results from a national survey of Danish inhabitants between 18 and 59 years of age, consisting of 2,403 employees that reported working in offices. Based on the survey results, office workers were divided into four categories according to type of office:
The different types of offices were characterised according to self-reported number of occupants in the space. Sickness absence was assessed with the question "In total, how many sick days have you taken in the last year?" The main comparison was self-reported sickness absence days depending on the type of office. The analysis was adjusted for factors that could influence the rate of days off sick (confounders), which included:
What were the basic results?The average (mean) number of self-reported sick days in the last year by number of people in the office was as follows:
Compared to cellular offices containing one person, this meant:
How did the researchers interpret the results?The researchers' concluding remarks are included below in full: "Open plan offices have become popular because they are designed to facilitate communication and accommodate knowledge sharing. However, our study showed that occupants sharing an office had a significantly higher number of days of sickness absence than those in cellular offices. Consequently, employees, employers, and society in general pay a high price for the benefits of open plan offices in terms of sickness absence and loss of productivity." ConclusionThis survey-based research suggested people in open plan offices may experience more days of sickness than people who have their own office and don't share. The results only show an association and do not prove cause and effect. Neither did the research investigate what might be causing this relationship, although it did speculate about this in its discussion of the results. The study had some strengths, including that it managed to recruit a reasonable number of people, but it also had many drawbacks that limit the conclusions that can be drawn from it. The research only looked at sick days. The Mail Online's reporting about people in open plan offices being "less productive and less happy" was drawn from other research. This could well be accurate, but was not reviewed here. Nonetheless, in the discussion, the researchers of the Danish study pointed to five possible explanations for how open plan offices might lead to more sickness leave:
Another possible explanation, not discussed by the researchers, could be cultural. If you work in a large office where your co-workers are frequently taking days off sick, then you may be more tempted to take time off yourself. None of the above explanations were explored in the Danish study and all remain speculative. A common reason that the open-plan office environment is popular with employers is they tend to be cheaper in terms of operating costs such as heating and lighting. An arguably interesting avenue of research would be to see if the perceived economic benefits of an open-plan office were actually outweighed by the alleged disadvantages, such as increased levels of sickness and reduced productivity. Analysis by Bazian. Edited by NHS Choices. Follow Behind the Headlines on Twitter. Links To The HeadlinesOpen-plan offices make employees 'less productive, less happy, and more likely to get sick'. Mail Online, May 23 2013 Links To SciencePejtersen JH, Feveile H, Christensen KB, Burr H. Sickness absence associated with shared and open-plan offices – a national cross sectional questionnaire survey. Scandinavian Journal of Work, Environment and Health. Published online May 2011 Research could lead to 'universal' flu vaccine
"Scientists create new flu vaccine that works against many different strains of the virus," The Independent reports. This headline, and several others like it, is based on early stage research into the development of alternative flu vaccine technologies. While the results of this research are promising, they do not mean that a universal flu jab has been developed. The study used a new technique where two proteins are bound together to form a nanoparticle. These nanoparticles stimulated an immune response to a greater variety of flu strains than the currently available flu jab. It is important to stress that this work was carried out in ferrets not humans. Ferrets do have biological similarities to humans, at least in the way they respond to flu and the flu vaccine, so this is a genuinely intriguing development. But it will take several years of further clinical trials to assess whether this technique can lead to a safe and effective 'universal flu' vaccine for humans. Currently, the best bet is to take measures to protect yourself during peak flu season. This includes regularly washing your hands, staying home from work or school if you have the flu and getting a yearly flu jab if you're at risk of serious complications. Where did the story come from?The study was carried out by researchers from the Vaccine Research Center, part of the US National Institutes of Health (NIH) and was supported by the NIH. The lead researcher is now based at Sanofi, a pharmaceutical company that manufactures vaccines. The study was published in the peer-reviewed journal Nature. BBC News reports the findings of the study in an appropriate manner. The headline "Universal flu jab 'edges closer'" and the warning that "a vaccine which could defeat all flu was a long way off" properly convey the stage this research is at. But most other reporting on this study failed to do this. For example, The Independent's headline "Scientists create new flu vaccine that works against many different strains of the virus" is premature and does not reflect the early stage of technology development that this research is at. While the work is a step towards a universal vaccine, the technology has not yet been developed and tested to a point at which it could replace the annual flu jab. What kind of research was this?This was a laboratory and animal study that investigated a new approach to generating flu vaccines. Current vaccines are designed to protect against three strains of the flu virus that health experts expect to be widely circulating in the population during any given year. This current approach is limited by the fact that the annual vaccine may not match the most common strains circulating that year. This approach also means seasonal flu vaccinations must be carried out annually to 'catch-up' with any changes in flu strains. The aim of this study was to develop a technique targeting a protein that is common to a wide variety of flu viruses, thus priming the body to mount an immune response to a broader range of flu strains. This research is at a fairly early stage, but it does suggest that it may be possible to develop a universal flu vaccine. The technology will need to be tested further in animals. It will then need to be proven to be safe and effective for people during clinical trials before a 'universal jab' could be made available. What did the research involve?Researchers fused together two proteins – one, called ferritin, which stores iron and occurs naturally in our blood; the other, called haemagglutinin (HA), which is a viral protein responsible for the initial stages of flu infection. It works by attaching the flu virus to the cell it is going to infect. Individual ferritin proteins naturally come together and form a smooth hollow ball. Researchers thought that fusing ferritin and haemagglutinin would result in a similar sphere with HA spikes, and that the resulting nanoparticle would be recognised by antibodies. They further thought that when the spheres were injected into animals they would trigger the body to mount an immune response against a range of flu strains. To test the ability of this ferritin-haemagglutinin nanoparticle to initiate an immune response, researchers first immunised ferrets with either a traditional flu vaccine or the new complex. They measured the HA titres (titres indicate the number of antibodies the body has produced that recognise the HA spike) three weeks later, and compared the titre levels between the two groups. Researchers then tested the ability of the ferritin-haemagglutinin complex to protect against a range of flu strains. Three groups of ferrets (one immunised with the new complex, one immunised with a traditional flu vaccine and one non-immunised control group) were exposed to a variety of flu strains. The immune response across the groups was then compared. What were the basic results?The researchers found that when the ferritin and haemagglutinin proteins were fused together, the proteins self-assembled into a nanoparticle with haemagglutinin spikes sticking out from the core. When the nanoparticle was exposed to an antibody known to target HA, the researchers found that it bound to the antibody in a similar manner as traditional flu vaccines. They say this indicates that the newly developed ferritin-haemagglutinin particles resembled the HA spike of the flu virus, which, in theory, could stimulate an immune response against a flu infection. Three weeks after immunisation, the researchers found that ferrets injected with the ferritin-haemagglutinin nanoparticle had levels of antibodies (antibody titres) that were approximately ten times higher than those seen in the ferrets injected with the traditional flu vaccine. They also found that a single injection of these nanoparticles produced an immune response similar to two immunisations with a traditional vaccine. When challenged with different flu strains, the ferritin-haemagglutinin immunised group of ferrets demonstrated an earlier immune response than the control group, and suffered less weight loss than both the traditionally immunised and non-immunised ferrets, which researchers say further demonstrates the protective effect of the new ferritin-haemagglutinin particles. How did the researchers interpret the results?The researchers conclude that this new HA-nanoparticle technology "represents a foundation for a new generation of influenza vaccines and could be adapted to create vaccines for a wide variety of pathogens". ConclusionThis is promising research that takes us a step closer to developing a universal flu vaccine. Despite headlines suggesting otherwise, no universal jab has yet been developed. The researchers say that this new particle is capable of enhancing the body's immune response compared with the currently used flu vaccine, and that the new complex offers protection against a wider variety of flu strains. It is important to remember that this research is still in its early stages. This technology development may well lead to the generation of a new type of vaccine. However, significant research is still required to move from the current stage to an available universal flu jab. Until then, the advice for protecting yourself during flu season remains the same:
Read more about preventing the spread of flu. Analysis by Bazian. Edited by NHS Choices. Follow Behind the Headlines on Twitter. Links To The HeadlinesUniversal flu jab 'edges closer'. BBC News, May 23 2013 An end to annual flu injections? Scientists develop new 'universal' jab against all strains of influenza which could last a lifetime. Mail Online, May 23 2013 Scientists create new flu vaccine that works against many different strains of the virus. The Independent, May 22 2013 Concept flu vaccine may be breakthrough. Sky News, May 23 2013 Links To ScienceKanekiyo M, Wei C, Yassine HM, et al. Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies. Nature. Published online May 22 2013 Do iPads and electric lights disturb sleep?
"Terrible night's sleep? Blame your mobile phone" is the advice on the Mail Online website, as "exposure to artificial light 'fools' the brain into staying awake." This – and similar headlines in the Daily Express, The Guardian and Metro newspapers – is based on a recent opinion piece in the journal Nature, which has published a dedicated supplement on the science of sleep. The opinion piece suggests that the invention of electric light has altered our sleep patterns over the last century. In particular, the widespread use of LED lights, which we rely on to view smartphones, tablets, televisions and laptops screens, is disrupting our sleep. This, the author suggests, could have potentially serious health consequences, as poorly controlled insomnia can cause both physical and mental health problems. As an opinion piece, this should not be taken as evidence that light exposure hampers our ability to sleep. However, it does suggest several ways the two may be linked. The piece offers the theory that one causes the other, but these associations have not been directly tested. But given that the author is a specialist in sleep medicine, his opinion cannot simply be dismissed out of hand. Who wrote the opinion piece?The editorial was written by Charles Czeisler, a professor of sleep medicine at Harvard Medical School and chief of the division of sleep medicine at Brigham and Women's Hospital in Boston, US. Over the past 35 years Dr Czeisler has published widely on sleep, the impact of light on sleep, and the effect of restricted sleep on human behaviour and performance. What arguments are made?Dr Czeisler suggests that since the invention of electric light, there has been a fundamental shift in our sleep patterns. He argues that light has enabled us to evolve into a "24/7 society", and that many of the features of this transformation – early starting times at work and school, long commutes, high doses of caffeine – lead to us getting insufficient amounts of sleep. Dr Czeisler's arguments for the link between the increasing use of electric light and disrupted sleep have highlighted several issues. The biological effect of artificial lightDr Czeisler argues that exposure to artificial light during the evening and at night could block the effects of brain cells that help promote feelings of sleepiness, as well the "sleep hormone" melatonin. At the same time, artificial light could also stimulate brain cells associated with alertness. The combination of these effects could result in many of us feeling much less sleepy in the evening than we would normally. Time-trends in light use, cost and sleepDr Czeisler reports that the cost of generating light dropped dramatically over the last 50 years, which was associated with an increase in the use of artificial light. At the same time that the use of artificial light increased, reported levels of sleep deficiency also went up. A recent study looking at data in England from 1993 to 2007 found a continual increase in people seeking treatment for sleep disorders. However, it is important to note that, as with any observational time-trend data, this argument only outlines associations between light consumption and sleep deficiency, and should not be interpreted as there being a causal relationship based on this editorial alone. Increased use of LEDsDr Czeisler suggests that the recent move from traditional incandescent light bulbs to more energy efficient solid-state light-emitting diodes (LEDs) could further disrupt our sleep. LEDs are commonly used in TVs, computer screens and handheld electronic devices such as tablets. These LEDs are typically rich in shortwave length (blue and blue-green) light, which the cells in our retina are more sensitive to. He offers the theory that time in front of these blue light-rich screens at night will be more disruptive to our sleep than incandescent lighting. Interestingly, one of the final discussion points in the editorial is about our ability to control the wavelengths emitted by LEDs. Dr Czeisler suggests that any adverse effect of exposure to these lights at night could be mitigated by replacing blue heavy light with red or orange heavy light in the evenings. This editorial offers interesting discussion points surrounding the relationship between light – especially evening or nighttime exposure to light – and difficulty sleeping. What evidence is cited?Dr Czeisler's article makes reference to several publications, mainly centred around trends in the average number of hours adults and children sleep each night, and the prevalence of the adverse effects of sleep deprivation. As an opinion piece, the overall discussion points are narrative in nature and are not based on any individual piece of research or evidence. This specific article on its own cannot provide evidence of a direct link between light exposure and sleep deprivation. However, it is not intended to do so. It offers a broad introduction to a series of articles on the topic, and suggests we consider the ways in which technological changes may impact our ability to get a good night's sleep. ConclusionIt is certainly possible to reduce your exposure to artificial lights. For example, you could dump your smartphone, give away your iPad, banish television from your home, and refuse to work in any job that involves using a computer. But adopting this kind of luddite lifestyle is probably not to most people's tastes. One proven method of improving your sleep is what is known as "sleep hygiene". This is where you control both physical and environmental factors in order to promote sleep. Examples of good sleep hygiene include:
Read more advice about sleep hygiene. If you have persistent insomnia (more than four weeks), contact your GP for advice. You may require more in-depth "sleep training" counselling, often done using cognitive behavioural therapy (CBT) techniques. Alternatively, there may be an underlying condition contributing towards your insomnia. Read more about the treatment of insomnia. Analysis by Bazian. Edited by NHS Choices. Follow Behind the Headlines on Twitter. Links To The HeadlinesPeering at bright screens after dark could harm health, doctor claims. The Guardian, May 22 2013 Terrible night's sleep? Blame your mobile phone: How exposure to artificial light 'fools' the brain into staying awake. Mail Online, May 22 2013 How your iPad tablet could mess with a good night's sleep. Metro, May 23 2013 Links To ScienceCzeisler C. Perspective: Casting light on sleep deficiency. Nature. Published online May 23 2013 |


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Based in Newport on the central Oregon coast, Oregon Coast Council for the Arts (OCCA) is the hub of coastal arts opportunities, offers exceptional variety, provides world-class arts experiences, strengthens the arts, and nurtures the artist in everyone through education. OCCA serves Clatsop, Tillamook, Lincoln, Coos and Curry counties, as well as coastal towns in Lane and Douglas counties, as regional arts council. OCCA also manages the Newport Performing Arts Center (PAC) and Newport Visual Arts Center (VAC).
Rick Bartow is the 2013 Community Legend.
A live jazz benefit for Oregon Coast Jazz Party.
James Graham's biting new play on July 5.
Helen Mirren stars in "The Audience" on July 12.
Crafts on the Coast Arts & Crafts Festival, a juried event, brings together nearly 70 of the best artisan ... Learn More

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The woman next to me at the birthday lunch paused before digging into a gigantic piece of chocolate cake. "I really shouldn't be eating this," she said. "I gained almost twenty pounds over the past three months." Then she shrugged and said in exasperation, "But what's another 20 pounds when I have to lose 200?"
"I thought of going to your weight-loss clinic," she added before resuming her eating. "Frankly, though, what I need is a marriage counselor, not a diet program." Abigail (not her name) then briefly outlined the stresses that caused her to reach for food continually: Her husband had not earned any money for years and was not interested in looking for a paying job. He wrote books that he self-published and claimed that he was too busy to participate in the logistics of running the house. In addition to holding a full-time job with unpaid overtime, Abigail had to pay bills, do the taxes, clean, cook, shop, and, of course, take care of the children. She sputtered when she told me that her husband even expected her to visit his father who was recovering from a heart attack because he, the son, didn't have the time. The husband, who was also considerably overweight, insisted on large, fattening meals along with snacks that he could munch on while he wrote. "So who also eats the snacks? Who eats all the leftovers? You can see them on me: They are all on my hips and stomach, "she said. "It is easier to eat than to fight with him about everything." In the interests of self disclosure, I heard only her side of the story. And who knows, maybe her husband's obesity could also be generated by his own dissatisfaction with his marriage and his life. Nevertheless, I agreed with Abigail that simply going off to a Weight Watcher's meeting or getting private diet counseling was not going to solve her weight problems. She knew why she was overeating, but felt equally helpless about solving her weight and her marital problems. Overeating is often the symptom that something is wrong with some aspect of one's life. Unfortunately, diet advice to bring the overeater back to a normal weight overlooks the causes of the excessive food intake or offers no help in preventing it other than suggesting the use of will power. Losing weight should not be deferred until the stresses and triggers that caused overeating are identified and removed. Someone like Abigail, who is so overweight as to make her vulnerable to a variety of health problems, should not wait until the problems with her husband, along with her exhaustion, stress and anger are resolved. But, as she said, she needed a marriage counselor (or life coach or psychologist) as much as a diet plan to be successful in losing weight. One of the benefits of a slow weight-loss program is to allow enough time, perhaps a year or more, to work on the problems that caused the overeating. Abigail's problems were complex, and she needed to look at her restrictions and priorities anew, so that she felt entitled to eat foods that allowed her to lose weight and take time to exercise. But how could Abigail shift her palate to better nutritional choices? Could she do this within the confines of her marriage? She needed professional guidance, and not a diet counselor, to help her answer that question. But I convinced her that as long as she stopped gaining weight and started to lose, albeit slowly, she would have the time to work out the answers. And perhaps as she lost weight, she would gain a happier life. | permalink | related link | ( 3 / 161 ) All of us are familiar with the change in our bodies after a severe flu, broken limb or difficult surgery. Our weakness and inability to move with the same speed and strength possessed before getting sick is due not only to the illness itself, but also from muscle loss. For example, my close relative recently had pneumonia, and the wonders of modern antibiotics brought about a quick end to the chest pain, fever and coughing. More than a week later, however, this normally athletic, fast-moving individual was having trouble climbing stairs and walking long distances. Oftentimes the newly felled by sickness are often unpleasantly surprised to find themselves temporarily debilitated this illnesses, and indeed go through several weeks or even months, of physical therapy and rehabilitation programs to regain our strength and stamina after the bout of sickness is over. But what if the deterioration of the body is due to mental illness? What if the loss of muscle strength and muscle wasting is due to weeks or even months of inactivity because of the extreme fatigue and weakness that may accompany depression and anxiety? What if an individual is so depressed that moving from a bed to a chair seems too hard, and as a consequence, the lack of days or weeks of physical activity brings about muscle loss and weakness? Several years ago a woman who had been coming to our weight-management center at a Harvard-associated psychiatric hospital suddenly disappeared. Several weeks later, when her severe depression lifted, she came back and told us that she was unable even to make phone calls during the worst days. The trainer who had been working with her in our program's exercise routine noticed that she had lost stamina, was unable to do her previous aerobic and strength-building exercise routine, and had trouble with her balance. The days of simply not moving had taken its toll. She was fortunate, however. The trainer knew what her body was capable of doing before she became depressed and was therefore able to help her regain her former level of fitness. But what about others whose mental illness causes them to experience periods of physical inactivity as severe as those suffered by someone recovering from injury, infection, chemotherapy or heart disease? Do their therapists recognize the physical debilitation caused by their mental illness? Are the patients given nutritional advice to help them restore lost muscle mass, and are they referred to physical therapists or trainers to restore their lost physical fitness? While I suspect that these patients are given appropriate medication and therapeutic counseling. But I also suspect that the counseling does not include recommendations as to how to increase muscle mass, increase stamina or improve their balance (a particular problem if the medications make them dizzy). Because of my decade-long interest in reversing weight gain caused by antidepressants, I have heard from many who have experienced this problem. Most people who contact me write that their medications increased food intake and subsequently their weight. But some insist that they are not eating any differently, and yet their weight increases anyway. They ask if the drugs might be slowing down their metabolism? Unfortunately I am not aware of any studies that compared metabolic rate before and during treatment with antidepressants and mood stabilizers (drugs used for bipolar illness) to see if indeed such drugs decreased metabolic rate. But perhaps if their metabolism is slower, it is not due to the drugs, but due a decrease in muscle mass? Muscles are the greatest users of calories in our body. Thus prolonged inactivity during a depressive episode might deplete muscle mass as readily as it does when someone is forced to stay in bed because of a serious infection or complication of surgery. If so, this would account for a drop in metabolism and subsequent weight gain without a change in food intake? Fortunately, as anyone who has had a broken limb or bad flu knows, it is possible to reverse muscle loss by exercise and sufficient protein intake. (Women should be sure to eat at least 55-60 grams, and males 75-80 grams, of protein each day.) The same program will work for people who are recovering from mental illness. And if prolonged physical activity has caused major muscle weakness and loss of balance, it should be possible to enlist the service of physical therapist to start the recovery process. It may take time, but certainly will be successful, if given the support it needs. | permalink | related link | ( 3 / 227 ) The slush and remnants of snow were still on the muddy ground when the ice cream truck appeared at the corner of the park by our house. It will be there, each day, until summer passes and Thanksgiving weekend is over. Several weeks later, the lines are long and as many adults as children wait for their soft-serve ice cream cones and cups. Yesterday, a man wearing a well-tailored suit and carrying a briefcase walked away with a cone that towered so high, I hoped he had a stack of napkins to catch the inevitable drips. Eating ice cream -- or its close cousins gelato, frozen yogurt, sorbet or soft serve -- is a seasonal treat (like buying the first bunch of daffodils or tulips), and as such should not be denied just because one is on a diet. And unless the dieter is following a program that forbids eating any sweet, creamy food that is cold on the tongue, it should be possible to fold the calories from one of these frozen delights into the day's calorie count without inhibiting weight loss. The key seems to be sticking to a half-cup serving size and avoiding the tempting but truly fattening sundaes and added high-fat ingredients. Should you choose gelato over ice cream? Frozen yogurt, be it Greek or not, over ice cream? Perhaps soft serve versus hard ice cream? It turns out that the calorie count for all of these products hovers around 200 for a half-cup. Unless you are eating a fat-free, sugar-free item that is mostly air and filler, the difference is really in taste and texture. Gelato is the Italian version of ice cream. It is sweet and creamy, and if you find a gelato store, you will be dazzled by the array of colors and flavors. Gelato has somewhat fewer calories than ice cream; an average half-cup serving has 150 calories versus 200 from regular ice cream because it contains less butterfat. However, it actually tastes creamier. The reason is that much less air is beaten into the mixture, giving it a denser mouth feel. In fact, it is so dense, it is impossible to eat quickly, thus extending the enjoyable experience of eating it. What about frozen yogurt instead of ice cream? Or Greek frozen yogurt? Although it seems reasonable to assume that the frozen yogurts are less caloric, the caloric difference between them and ice cream may be unimportant. Ben & Jerry's Cherry Garcia Ice Cream (half-cup) is 240 calories, while the company's Raspberry Fudge Chunk Greek Frozen Yogurt (half-cup) is also 200 calories and its Fudge Brownie Frozen (non-Greek) Yogurt (half-cup) is 180 calories. If your frozen Greek yogurt scoop drips while you are eating it, the calories may end up the same. Sorbet has fewer calories, around 150 per cup, and most flavors are fat-free. However, chocolate and coconut sorbet do contain some fat and are higher in calories. The calorie contents of soft-serve ice cream that comes out of a nozzle and can be whirled into a tower with a little comma on the top may vary much more. For example, soft-serve JP Licks has 150 calories for a half-cup, while Tasti D-Lite is considerably less, mainly because it contains very little fat but lots of gum and other thickening agents. But, if you add hot fudge topping and whipped cream to even light soft-serve ice cream, the calories bounce up to well over 300 a half-cup serving. The problem with all these calculations is the serving size. The calorie counts depend on the size of the scoop, and also on whether a cone or cup is dipped in a fudge coating and/or cookies, nuts and candy are added into the mixture. It is hard to imagine how the six-inch-high ice cream lapped up by the man in the suit could fit into a half-cup serving. A half a cup is not a very large measure. Indeed, even so-called kiddie cones seem to come in larger sizes than a half-cup. A few years ago, Good Housekeeping surveyed serving sizes of ice cream around New York City and found no consistency in the amount scooped. Maybe it depends on how tired the wrist of the server is so that by the end of the day, less is put into the cone or cup than when the server comes to work. Perhaps the most strategic approach to indulging in ice cream or other frozen delights while dieting, is to be cautious in what you choose. Kiddie-size cones or cups will approximate the half-cup serving size, and if you choose low-fat ice cream or frozen yogurt, you should be eating no more than 200 calories, more or less. Avoid waffle cones; they have 120 calories compared to 17 in a regular cone and 20 in a sugar cone. As yummy and tempting as they are, don't pick ice cream stuffed with chocolate, caramel, nuts, cookie dough and peanut butter -- and no hot fudge sauce. The pleasure of an ice cream in the summer should come from the combination of warm sun on your skin and cold ice cream on your tongue. And that should be enough. | permalink | related link | ( 2.9 / 19 ) I spend time in a city where people often have their cars parked by a valet. Indeed, I was told that if valet service was not offered at events, people would not come. "But there are parking garages only blocks away," I protested. "Can't they walk a few blocks?" The answer was an overwhelming, "No!" I thought of this while scanning a summary of a major study looking at the impact of running and walking on various measures of health such as blood pressure, cholesterol, diabetes, and heart disease. The study, recently released online in the journal of Arteriosclerosis, Thrombosis and Vascular Biology, reported the same health benefits for walkers and runners if they expended the same amount of energy while exercising. [1] This study, which lasted six years, enrolled 33,060 runners and 15,045 walkers who were dedicated to exercising. Records were kept of the amount of metabolic energy ("MET") expended by the volunteers when they were running or briskly walking, and then comparatively analyzed. The results of the study are good and bad news for those of us who wonder what type of exercise is best for our health. Runners and walkers whose exercise used up the same METs had the low risk of developing diabetes and cardiovascular problems. That is the good news. But the sort of bad news is that runners expended more energy per unit mile they ran than walkers covering the same distance, and this translated into better health outcomes. The reason for this discrepancy is that running is a less efficient way of moving, and so mile for mile, the runner burns up more energy than the walker. (Unless the walker is dragging a Great Dane or stubborn dachshund on a leash.) According to one of the authors, Paul Williams, a walker would have to cover 4.3 miles at a brisk pace to use the same amount of METs as a person running three miles. What this study seems to say is that if your exercise of choice is walking, it has to be more than a stroll around the block if substantial health benefits are to be achieved. Indeed, the walk ought to be fast and long for the exercise to produce, over time, a substantial decrease in the risk of cardiovascular problems or diabetes. But who is going to spend two or three hours a day walking? Obviously even the dedicated walkers in the study did not spend the extra time walking necessary to use up as much energy as the runners did in a shorter amount of time. And what about those who would not even consider walking more than a block or two to their destination? Those, who like many residents of Los Angeles, for example, insist on having a valet drive their cars to the parking garage so they don't have to walk. Or people all over the country that pull up to the door of the restaurant, or the mall to avoid more steps than necessary? I see this even with well-meaning friends who always offer me a ride home after a lecture or meeting and are surprised when I refuse, saying that it is only a 10 or 15 minute walk. The results of this major study are compelling as predictors of health risk. Yet how can they be translated into behavioral change? There has to be a cultural shift away from instant convenience, e.g., the valet, or saving a few minutes of time (the ride rather than the walk) or comfort. Rather than being annoyed at having to walk a few blocks because you couldn't park your car next to the door of the restaurant, be pleased at yet another opportunity to rack up a higher MET and consequently burn a few calories. Moreover, if we are going to suggest dedicated walking as the exercise of choice for health benefits, then it has to have some pleasurable aspects to it. Otherwise it will be abandoned as a passing fancy. Here are some ways of making walking tolerable, and perhaps even enjoyable: 1. Map out your route using Google map or other GPS supported directions. Know how far you are going and when it is time to go further, use your GPS or map to plan another longer route. You are not a goldfish restricted to moving around in the equivalent of a glass bowl. 2. Consider buying walking sticks. They should come with rubber bottoms so they hit the pavement softly and give you support. The length has to be adjustable and the hand holds comfortable. Walking sticks, aka hiking poles, make your arms move as well as your legs, are useful for going up and down hills (this is why hikers use them), and for older walkers help with balance. Also, they make you look athletic. 3. Triumph over walking boredom by walking with a friend, chatting on the phone with people whom you otherwise do not have time to call during the work day, or listening to lectures or books on your iPod. (I listened to an excellent lecture course on the history of the Civil War while dragging the aforementioned dachshund on his daily rounds.) 4. Activate a pedometer on your phone, iPod or wrist device so you really know how many miles you have covered. 5. Remind yourself to keep up the pace... for a healthy heart you must walk briskly. 6. Take water and dress appropriately. A small knapsack is useful for holding layers that you take off as you get warm or put on if the weather should suddenly change. Or simply enjoy. Turn off your phone and enjoy the fresh air. Reference: [1] http://atvb.ahajournals.org/content/ear ... 8.abstract | permalink | related link | ( 3 / 436 ) Losing weight should have a positive effect by mitigating health risks and improving overall well-being. And, of course, for anyone struggling with the consequences of being overweight, dropping those extra pounds restores energy, lowers both blood pressure cholesterol levels, and decreases stress on the bones and ligaments. But diets may take away more than pounds. There is evidence that diets can also take away bone strength. A few years ago, a study from Rutgers University revealed some worrisome findings on bone health. After only six weeks, the bones of the women on a weight-loss diet were not absorbing as much calcium as women who were not dieting, even though the dieting women were taking an additional 1,000-mg calcium supplement. Since these women were post-menopausal, the researchers suggested that dieting itself might make older women more vulnerable to fragile and easily breakable bones. Since many weight-loss plans don't emphasize the need to consume calcium-rich dairy products (Weight Watchers is an exception), the obvious answer to the prevention of weakening bones is taking a calcium supplement. After all, haven't women been told for years that supplements are a reliable source of calcium, especially for people who may not eat dairy products (like vegans or people who don't like foods that come from milk)? Now it looks like calcium supplements are out, and calcium-rich foods are in. Jane Brody recently discussed the latest information about the benefits and risks of calcium supplementation in the New York Times Science Section. She reported that the United States Preventive Services Task Force reviewed over 130 studies on whether calcium and vitamin D supplements prevent bone fractures. Their conclusion: They don't. It turns out that calcium from food is substantially more effective in promoting bone health than calcium taken as a supplement. Moreover, some reports have now pointed to a significant link between calcium supplements and an increased risk of heart attacks. This information that calcium supplements are not as reliable as food in maintaining bone health removes the safety net that many women depend on. This is especially true for dieters because knowing that you, the dieter, could swallow a couple of calcium pills made you confident that you were getting enough of this vital mineral, even if you stopped eating dairy products to save some calories. So now what do you do? The first thing is to know how much calcium you should be taking into your body every day. Women and men under 51 need 1,000 mg a day. Women need 200 more mg over 51, so their daily intake should be 1,200 mg. No one yet knows why weight loss should increase the need for calcium, but there is useful information about the best way to get your bones to absorb this mineral: You should not eat more than 500 mg of calcium at any one time, because that seems to be the maximum amount that a body can process per ingestion; Sunshine, or other sources of vitamin D, are necessary for calcium absorption. If your skin is not exposed to vitamin-D-enhancing sunshine, do take a supplement or eat vitamin-D-fortified foods (cod liver oil, of course the worst-tasting, is probably the best source); Caffeine in coffee and chocolate, as well as caffeinated energy drinks and sodas, increase the loss of calcium from the body. Don't overdo it on the caffeine or else your bones may become too weak to support your energized body; Just because a food contains calcium doesn't mean it will be absorbed by your body. Whole grains, peanuts, soybeans and most leafy green vegetables like spinach contain compounds that stick to calcium and prevent the mineral from entering your body. Kale, mustard greens and collard greens are exceptions, as they don't contain the calcium-grabbing compounds. (Tofu, which is made from soy, will yield up calcium if it is processed with calcium sulfate and nigari. FYI: Nigari is the Japanese name for magnesium chloride. Both compounds are responsible for the formation of the solid part or block or the tofu.) Read food labels. How else can you decide between cow, soy, almond, and rice milk? They all vary in calcium content and calories, and some of these dairy milk-like beverages are now fortified with more calcium than they were just a few years ago. Many foods that normally are calcium-free, such as orange juice and Total cereal, are also now calcium-fortified. If you put orange juice on your cereal in the morning (as my lactose-intolerant friend does), you may consume most of your calcium needs at breakfast; and to conclude, Convenience and calcium needs may conflict. Not all calcium-rich foods fit into your lifestyle, and dieting further limits what you can eat. Boiled kale and tofu burgers may not be foods you are going to prepare when you return from work at 8 p.m., so have alternatives available. Cottage cheese, yogurt and part-skim ricotta cheese are all low-calorie calcium sources, and can be blended into smoothies, pasta, soups, or used as toppings for calcium-fortified toaster waffles. Milk-based fish chowders are an excellent source of calcium, and if made with fat-free or low-fat milk, can easily fit into a dieter's menu plan. Lasagna layered with low-fat ricotta cheese or cottage cheese and steamed kale can be made ahead of time, frozen in mealtime portions, and then heated up for a quick dinner. And if you can spare the calories, one-half cup of frozen Greek yogurt provides 15 percent of your daily calcium requirement (about 150 mg of calcium) and tastes good, too. Even though dieting may make you vulnerable to bone loss if you don't take these dietary precautions, remember that diets often have a beneficial effect on bone strength. Exercise, that other component of weight-loss programs, is essential in strengthening bones. Indeed, physical activity is essential to prevent, as well as reverse, bone loss. And if you do burn off enough calories, you really can eat that frozen Greek yogurt without guilt. | permalink | related link | ( 3 / 527 ) Next |


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Creating a safe, beautiful nursery for your baby begins by determining your needs. To help you easily navigate the 'big-ticket' decision-making process, we have assembled a thoughtful collection of cribs, bassinets, organic mattresses, rocking chairs, changing tables and dressers. With the best of eco-friendly modern nursery furniture and timeless classics to choose from, there is a perfect solution for every budget.
Perfect thank u for all of your help!! Baby will arrive by next Friday at the latest and you have helped us immensely in getting the final touches on his room done. Thank you, thank you!!
- Alissa GOnce again, thank you for all your help. You've been great with checking on the status for me and as usual, fawn&forest's customer service has been wonderful!
- Devi WMy daughter received the Oeuf Sparrow bed and it arrived in perfect condition. The delivery went very well. She really appreciated the call before delivery. Thank you for following up.
- Deborah B.The Owyn Toy Box by Mod Mom is a modern organic-style storage piece designed to house lots of toys and/or household stuff.
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Owyn now has a mod sister! Maude by Mod Mom is the same size as the Owyn Toy Box but instead of housing two storage bins, this mod bird has one large toy bin as well as an open air book cubby.
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-5.25 x 4.25 (A2) folded card
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Julie Ann is a designer, photographer, and DIY lover. She started selling on Etsy in 2008 and it has changed her life. She is an avid supporter of handmade and independent businesses and continues to spread the word on the handmade movement.
Want to know more? Visit her blog at www.julieannart.com for DIY tutorials and giveaways!
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Oh no, sorry. They are ANYTHING eaters. I think its an interesting concept- especially if you start the dog off that way. Big dogs like mine would cost more than feeding my own children. I am struggling with that and thats enough for me- as my kid yells for cheerios from the next room .
Just feeding my little dog home cooked instead of bagged food. I am going to try the avocados on him though.:)


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TWINING'S® Earl Grey
You may add this item permanently to any of your Auto Delivery orders or create a new order. Enjoy the convenience of home delivery on a schedule you choose. Changes are easy to make at any time. Learn More
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- This package includes 16 Twining's® Early Grey T DISCS, so you can enjoy this classic delight anytime you like
- This tea makes an 8 fl oz cup
How to Make It
- Place your favorite mug (11 fl oz) on the cup stand.
- Insert the Twinings® Earl Grey Tea T DISC into the brewer; when the green Auto light comes on, press the button.
- Allow the mug to fill, and enjoy a steaming cup of this classic and comforting flavor.
About the TASSIMO System
ENJOY GLOBAL VARIETY. The TASSIMO Home Brewing System by Bosch makes one perfect cup at a time with the ease of T DISC technology. T DISCs are filled with fresh coffee or espresso grounds, tea leaves or milk creamer (which the system froths for the perfect cappuccino or latte). Slip in your favorite T DISC and in just about a minute, your brewer makes coffee (iced or hot), tea, cappuccino, latte, crema, mocha, espresso or hot chocolate just to your liking.
ASK FOR THE BARCODE. Each T DISC uses a special barcode that tells your brewer exactly what to do: the size of the drink, the amount of water required, its optimal temperature, and how long to brew it. It's like the know-how of a seasoned barista right at home. All the brewing happens inside the T DISC, keeping the machine clean and ready to use. You can also manually control the strength of your drink with the press of a button.
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When will you offer a green tea? With all the antioxidants this is what people want today.
I've personally been getting a little creative with the discs and coffee acoutrements that I can buy. If you look at Tassimo's selection on the European market, they seem to have 2 - 3 times the choice of what we can buy here in the States, which lead me to buying some Tassimo samplers from coffee shops in the UK which will ship to me inexpensively. This may be a bit too much work for some people, but to me it's worth it.
I've also purchased some flavored syrups from a US company called Amoretti, which are quite amazing. Adding just a squirt of the syrup to a plain Maxwell House or Gevalia Latte can give you a wonderfully flavored drink like Gingerbread, Tiramisu or English Toffee.
Lastly, I mix and match my discs. Sometimes I'll run an Espresso disc into a mug of Hot Chocolate. Or Hot Chocolate with Latte creamer. Or Crema with Latte Creamer and a shot of flavored syrup.
I know some people will say the extra effort defeats the purpose of buying a Tassimo. I disagree. At this point, I consider myself and "Express Barista". I can have a wonderful tasting original beverage in under 3 minutes (all while I'm cooking my breakfast on the side), without a lot of clean-up or fuss.
But hopefully, Tassimo will be making more varieties for us soon and hopefully the shortages will also be a thing of the past in the near future too :)
Tassimo's stock changes on a daily basis. While Tassimo does it's best to keep all products available for customers, occasionally the supplies run short due to popular demand. Tassimo is working to have all products available to our customers both online and in stores.
Earl Grey Decaf TeaK-CUP® TEA.The same great taste of Earl Grey tea, without the caffeine. A light and aromatic blend of fine black tea, scented with bergamot, a citrus fruit.
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caitlin wilson design
Had a really great afternoon with designer Caitlin Wilson and her daughter in one of her client's homes. What a talent --and what a gorgeous home she designed. See for yourself! Oh.. and ps.. can you even believe how beautiful Caitlin is? Seriously.
*update: this home is in Presidio Heights in San Francisco
© nicole hill gerulat for caitlin wilson design


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Product Details
The Autocare 3 cycle rear mounted carrier is great for families who enjoy exploring the great outdoors. Easy to fit, this bicycle carrier allows you to transport 3 bikes on the rear of your vehicle. With 6 nylon fixing straps included, your bikes will be kept securely in place while travelling.
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Key Information | |
Type | Rear |
Storage | |
Maximum Load Capacity (kg) | 40kg |
Carrying Capacity | 3 |
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What"s in the Box | Includes: fixings |
Dimensions | |
Product Height | 51.0 CM |
Product Width | 70.0 CM |
Product Depth | 8.0 CM |
Product Weight | 4.5 KG |
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HURRICANE, W.Va. — It takes all four quarters to win a game.
The Point Pleasant girls basketball team held Hurricane to just six third quarter points en route to a 53-44 victory in the sectional semi-final in Putnam County.
The Lady Knights (8-15) jumped out to a 12-to-9 lead at the end of the first period, led by senior Sarah Hussell, who scored the first 11 PPHS points. The Lady Redskins (6-17) were led by Abby Watson in the first period with eight of the team's nine points.
Point Pleasant pulled down 18 rebounds in the second period but shot just 4-of-23 (17.4 percent) from the field, allowing Hurricane to pull within one point at halftime. PPHS led 26-25 at the break.
The Lady Knights didn't turn the ball over in the third quarter, which allowed them to expand their to 43-31 with eight minutes remaining.
HHS closed the game with a 13-to-10 run but the Lady Knights held on for the nine point victory.
"My seniors told me Friday night that they didn't want to practice Saturday," Point Pleasant coach John Fields said. "We generally have a last practice for the seniors when we run into the possibility of elimination. They told me on Friday, that we were not practicing Saturday at 8:00 coach because we will have another one. They believed from the beginning, I believed and everybody came out and played hard."
Hussell led the Lady Knights with 17 points, including five three pointers. Andrea Porter made two three-pointers and finished with 16 points, while Allison Smith and Katie Bruner each marked eight. Makenzie Thomas and Cassie Nibert each added two points, rounding out the PPHS scoring.
Point Pleasant shot 8-of-17 (47.1 percent) from the free throw line and 19-of-63 (30.2 percent) from the field. The Lady Knights grabbed 40 rebounds in the game, while turning the ball over just 13 times.
Watson made two triples and led the Lady Redskins with 22 points, followed by Taneisha Sturdavent with 10 points. Courtney Rogers had five points, Callie McClanahan added four and Audrey Barber marked three.
Hurricane shot 8-of-15 (53.3 percent) from the free throw line and 17-of-48 (35.4 percent) from the field in the game. The Lady Redskins had 33 rebounds and 21 turnovers in the game.
This game also served as the tie breaker between these teams, as Hurricane won the first meeting of the season, 60-33 on December 21st in Hurricane, and Point Pleasant won the second meeting, 55-29 on January 5th in Point Pleasant.
The Lady Knights will face host Winfield in the sectional final on Wednesday at Winfield High School. The Lady Generals are 11-11 on the season.


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Refinery29 x Joana Avillez
After the runaway success of our first round of Fashion Illustrator Tees during the holiday season, we decided to team back up with the great Joana Avillez for another round of wearable icons. We don't know about you, but we're wearing these tees everyday.
Former Vogue editor-at-large, America's Next Top Model judge, and even FLOTUS fashion consultant, André Leon Talley is our most favorite caped style crusader.
Product photographed by Jonathan Nesteruk. Model photographed by Bec Lorrimer; Hair and Makeup by Jake Sherwood; Styled by Laura Pritch
The Deal
Score this André Leon Talley Illustrator Tee for $25.
Measurements: Small: 14" shoulder; 29" bust; 24" long. Medium: 14.5" shoulder; 31" bust; 25.5" long. Large: 15" shoulder; 32.5" bust; 25.5" long.
Fabric: 50% cotton/50% polyester; machine wash
Details: American Apparel T-shirt; slight scooped neckline; printed illustrated design on front; durable ribbed neckline; form-fitting.
NOTE: These T-shirts run small! Please refer to the sizing measurements above to make sure you get the fit you're looking for.
Ships within 1-2 business days.The Fine Print
If you are not satisfied with your purchase of this item, we will gladly accept your timely return in original condition and unopened packaging.
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Sheet Music: Prelude for Lute, BWV 999 by J.S. Bach
Level: Lower-Advanced
License Information: Copyright of this arrangement © 2011 Emre Sabuncuoglu. All rights reserved. International copyright secured. Original work by J.S. Bach is in the public domain.
Lesson Program: LAGA Classical
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Thank you for your interest in purchasing sheet music through LAGA Publishing. Though brief inquiries are generally answered, purchase does not entitle instruction or support. Questions regarding notation, technique and performance can be addressed by enrolling in our online classical guitar course, LAGA Classical.


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Richard Brinlee, 58, of Trina Street in Patterson was arrested at 4:48 p.m. at his home, Sheriff Mark Hebert said.
The responding deputy was told the dog came out of the owner's yard and bit the 12-year-old boy on the leg while he was riding his bike, Hebert said.
The boy was transported to Teche Regional Medical Center in Morgan City for treatment of two puncture wounds. Brinlee was released on a summons to appear in court Jan. 16, 2013.
Also arrested by St. Mary Parish Sheriff's deputies Monday were:
—Juvenile female, 15, at 12:19 p.m. at St. Mary Alternative School for battery of a police officer. A deputy at the school responded to a report of a female student attempting to fight with another student. While escorting the juvenile from the classroom, she struck the deputy. The juvenile was released to a guardian.
—Cody Thibodeaux, 22, Fourth Street, Berwick, at 3:02 p.m. at the St. Mary Parish Law Enforcement Center in Centerville for simple criminal damage to property. A deputy at the jail responded to a fire alarm. During the investigation, the deputy learned that Thibodeaux, already an inmate at the jail, used a sheet to break the sprinkler in his cell triggering the alarm, the report stated. Thibodeaux remains jailed with no bail set.
—Juvenile male, 15, at 8:04 p.m. at the Bayou Vista Walmart for theft. A deputy learned from store security that the teenager was seen on video surveillance opening a package of headphones valued at $19.99. Store security retrieved the empty package from which the headphones were missing. The juvenile was released to a guardian.
—Jaime Boudreaux Lee, 34, Clausen Road South, Verdunville, at 9:48 p.m. on Fairview Street in Bayou Vista for obstruction of justice.
—Jasper Maurice Minor, 19, Sixth Street, Berwick, at 9:48 p.m. on Fairview Street in Bayou Vista for obstruction of justice.
—Anthony Charles Watts, 36, Clausen Road South, Verdunville at 9:48 p.m. on Fairview Street in Bayou Vista for obstruction of justice, failure to signal and child restraint required.
—Jerald Stansbury, 35, Clausen Road South, Verdunville at 9:48 p.m. on Fairview Street in Bayou Vista for resisting an officer by flight, failure to signal, driving under suspension, second offense possession of marijuana and obstruction of justice. Stansbury also is charged on a warrant for failure to appear for driving under suspension and license plate light required and on a warrant from Morgan City Police for simple battery.
St. Mary Parish Sheriff's Narcotics Division agents patrolling the Bayou Vista area observed a vehicle fail to signal a turn. When agents conducted a traffic stop, the driver, identified as Stansbury, fled on foot. Agents pursued Stansbury but lost sight of him. A bag of marijuana was located in the area where Stansbury fled, Hebert said.
Agents saw a vehicle continually driving around that same area, so a second traffic stop was made. The driver was identified as Anthony Watts. Three children were in the vehicle, none of which were properly restrained, the report stated.. Agents saw Stansbury attempting to hide on the floorboard under the legs of the minors in the vehicle, the sheriff said.
No bail has been set for any of those arrested in this investigation.
Morgan City Police Department Assistant Chief Glen Blanco said the following arrests were made over the weekend:
—Vincent Thomas, 19, of Fourth Street, Morgan City, at 4:02 a.m. Sunday, charged with resisting an officer, no driver's license, driving without headlights, and possession of drug paraphernalia. Thomas was the driver of a vehicle travelling east on La. 182 near Ditch Avenue. When officers stopped the vehicle, Thomas fled on foot, Blanco said. He was apprehended a short time later. Reports indicate a small suspected marijuana smoker's pipe was found on the floorboard on the driver's side of the vehicle, the report stated. Thomas was jailed with a bail of $1,681.
—Nicole Fisher, 41 of Federal Avenue, Morgan City at 12:15 p.m. Saturday charged with theft by shoplifting items valued at $53.61 at Dollar General. She remains jailed with a bail of $492.
—Craig Albarado, 48, of Diane Drive, Morgan City, at 9:50 p.m. Saturday charged on warrants for theft over $500 and theft under $500. Albarado was located on Pecos Street. He remains jailed with no bail set.
—Faibel Garcia, 33, of Aucoin Street, Morgan City, at 11:37 p.m. Saturday charged on warrants for two counts of no driver's license, speeding and stop sign violation. Garcia was located on Aucoin Street and advised of the warrants for his arrest. He remains jailed with no bail set.


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Please advise me on this site.
New site went with "Less is more" or kept it clean and simple.
Chamber of Commerce
Thanks in advance for your advice.The first word that comes to mind surelock about what I see is 'stark'. I might be missing something but the images, header one especially, appear very dreary, cold and uninviting. There's little that draws me in. I know you tried for less is more. I might try using a few more design elements here and try and brighten things up. Try using imagery that communicates that this city/town/area is one that has much to offer to potential visitors. I would shoot for brightening things up a little. Check out other Chamber of Commerce sites to get a feel for what they are doing and what's being communicated on their sites.I think if you want to keep it subtle you need to find some better colours for that menu - they are very in your face as to say.
Have a look around here - it might give you some ideas!
Also the banner image in the centre kinda cuts your eye a little, is there anyway you could blend them together in photoshop or maybe try a different approach?All right, when I said less is more I did not mean that I did not want to use interesting colors and provacative imagery, what I meant was keep it simple and use white-space effectively. I have viewed 20 or so chamber sites from various cities and a clean simple look is what seemed prevalent to me. I did some touch-up on the main banner image (I am still not overly pleased with it but it is filler until I get some actual pictures from the chamber to use), they also seem keen on the idea of a seasonal motif for each season, hence the blues and grays for winter time.I just think the blue is too default link blue if you know what I mean. When you could go for a theme like this...
It just makes the colours more interesting, and softer on the eye :)All right thanks Rob, I will check into it. Thanks to you as well rebelbwb.I love Kuler and use it for many different projects, from web to print.
You can still have a winter site, using winter colors, and have it warm and inviting. It just takes some skill and time.Thanks Doc, just off the top of your head is there a place that links to sites using these exact schemes for reference and inspiration? Thanks in advance.Not particularly, but I always check Web Designer Wall's "Best of":
http://www.webdesignerwall.com/trends/b ... sign-2008/
You can usually find something close. Luckily enough, there was a winter one:
http://winter.tnvacation.com/All right using the colors from the recommended scheme I reworked the page and added and extra color of my own. Please see if it has a warmer feel to it.
Summersville Chamber siteDefinitely an improvement.
I'd say your main content area is much too wide. People read much faster when text is tall, not wide.Yea Doc is right, and the colours seem more professional now too :)
nice job :)All right, having followed all advice I deemed worthy (everything really) I now present The all new and improved Summersville, Missouri Chamber of Commerce site.Good stuff. I still think the main content needs some more padding on the left and right though.Personally if you are going to have that much content (text), I always increase the line height a little to make the text easier to read. Also, try making your sidebar the darker color, that will make the main content pop more and be easier to read. Right now my eye is drawn to the left sidebar. Give the Headlines or Titles a little color.
I agree that the site has a cold feel to it, and it may be appropriate for a business type site like this. However I took a quick run through of your CSS and I saw that you used black and white for some of your elements. Try not to use the extremes, try #fdfdfd for white or #3a3a3a for the dark. You don't have to use those exact values, and even though they might be small changes, the subtle ones are what separate the good sites form the run of the mill ones.
Try to broaden / lighten the color pallete a little. Try this to get some ideas - http://www.colorsontheweb.com/colorwizard.asp
Good luck -
Thanks for the reply, I softened the extreme colrs and will peruse the site you mentioned. Please see if the current setup is more palatable. I am going to wait until the chamber meeting and see what the general concensus is before I change the color scheme as it is a winter scheme and I have a spring theme in the works as well.


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Belinda Fleischmann
MessageTo Stop the Japanese Whale Hunt-- for Good!
by Rachel June
SIGNING THIS PETITION DOES MATTER! Please help to make sure that Japan realizes that the world wants to see a complete and permanent end to their whaling program by signing this petition to the Ambassador of Japan to Australia, Mr. Shigekazu Sato. Let's put an end to this for the innocent animals


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"At first, nobody wants to use it. But, I mean, after a while, you have no choice," said Darryl Malone, a student at Texas A&M who was vacationing. "It got so bad, I was walking through the ship, and this little girl was like, 'I need a red bag; I need a red bag.' "
The crew tried to keep passengers calm as they slept on decks and waited in food lines, sometimes for as long as four hours. At times, the only food was stale vegetables.
The crew figured out one way to appease guests: "Free beer and wine for everybody," said chilled-out passenger Ed Buck.
The crew worked around the clock to try to make the situation somewhat bearable. They constantly checked on passengers, often with smiles on their faces.
"The people onboard the ship, the crew, has been amazing," said Trey Love, who was celebrating his 40th birthday on Triumph.
"They did the dirtiest work," said Dee Tucker, "doing things I wouldn't do."
"We've had our breaking moments. We've had our panic attacks. But it is what it is," Bethany Nutt said while the boat was still being tugged toward shore.
Once the ship docked late Thursday and passengers disembarked, the crew members were shuttled to hotels in Mobile. Carnival employees work on a contract basis, often on the same ship, for months at a time.
The Triumph workers will receive full and normal compensation and be sent to other ships or offered vacation if they had some scheduled soon, said Carnival spokesman Vance Gulliksen.
Crew member Sachin Sharma of India said workers had no problems with being thrust into the icky job of handling the red bags filled with human waste.


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Consumer Reviews of GOODMAN central air conditioners
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Location: sarasota, fl
Years owned: 3
Satisfaction Rating:
"Unreliable product"
Copper pipe used (exterior and interior) has developed leaks in 2 of 3 yrs owned. Warranty covered replacement part but not labor or 21 lbs coolant. $1500 in extra charges in 2 years.
Location: Hamlet NC
Years owned: 3
Satisfaction Rating:
"Great looking and running unit."
My Goodman has been great so far. It replaced a 22 year old Bryant unit. That in the last 5 years of having it, needed to be repaired twice and only put out 70� at the register. Great unit to last that long. I wanted a 3 ton unit, but my contractor said go with 2.5 as 3 ton was too big. So I got the 2.5, 13 seer. I thought $3000 was a good deal for the unit, pad, 7k heater coil, other things and installed. My house is right under 1400sq ft, so he was probably right. Now my air is 54� at the register. Boy has my power bill dropped. Registered online with Goodman, so my 10 year warranty is good to go. Unit still looks brand new. Now I'm scared of copper thieves.
Location: Richmond,Tx.
Years owned: 8
Satisfaction Rating:
"The noisest unit on earth"
You people make a good product but, I can't sit on my patio and talk to anyone when this unit is running. Why? Are these units going to stay loud?
Location: Merritt Island, Fl
Years owned: 6
Satisfaction Rating:
"Leaks and More Leaks"
I've had 5 coils replaced on two units and about to replace another 1 or 2 as both units froze up last night. In spite of what some of the professionals on here say, these units are defective by design, plain and simple. This is not an "installation" issue, there are almost 70% negative reviews on here and it is doubtful 70% of installations are defective and repeated as many times as some of us have experienced. Meanwhile the outside units hardware is corroding after only 6 years. If you cannot design and build hardware to last in the environment that it has to operate in (yes it gets wet,duh) then your warranty means nothing as the homeowner has to absorb the cost of labor and Freon at $40/lb plus replacement of parts not covered that are very expensive. The auto industry gets it why not the ac industry. I have an 11 year old car that is outside all the time, has no rust and the ac still works!
Location: North Carolina
Years owned: 5
Satisfaction Rating:
"Couldn't imagine a worse unit"
Lets start before the unit was installed to just paint the picture here. In 2001 my wife had a kidney/pancreas transplant. Her health has never been strong since that time. I'm glad she's alive but, she can't take a lot of abuse. So, about five years ago the Trane ac compressor quit. It was 12 years old. Nothing runs like a trane, except a Yugo. It was replaced by a professional with a Goodman. The Goodman has never run for more than three months at a time without a major repair. Even when brand new it was eating contactors which were burning out the transformers. We have gone through a pile of those. Even on it's best day it couldn't cool the house down on a hot day. Last year the compressor was seized and the HVAC guy "unfroze" it which lasted less than three months, at which time we just toughed it out till fall. Now summer is coming on hot already and we have no air. To top it off I find out that the installer charged me about $900.00 more than it should have cost. My new HVAC guy says that the unit is the proper size and should be able to cool. He's not impressed either. I spent way more cash than I needed to for a unit that simply doesn't work and never worked as it should. Goodman and the installer should be ashamed for screwing people who need reliable AC for health conditions. The love of money is the root of all evil, or so the book says.
Location: Oviedo, fl
Years owned: 3
Satisfaction Rating:
"Compressor says Pioneer"
Capacity 4100 Eer 13 Seer 15- I bought this unit 3 years ago paying $5,000 In Year 2 the capacitor went out. Now in year 3 the evaporator coil has gone out. While the parts are covered the labor is not. I just spent $200 in labor and the guy said he gave me a deal because the normal price is 800-900 dollars in labor. My previous unit was put in in 1983. When I had it replaced in 2007 it was still working just fine. It was a Trane and although today's may not be as good it has to be better than this Goodman piece of junk!
Location: Arlington, TX
Years owned: 10
Satisfaction Rating:
"Contractors View"
I am a contractor with 39 years in the industry. I am not associated with any brand of equipment other than I sell what I want to. I want the same thing that every homeowner wants: an efficient reliable system with an excellent warranty for a good price. Thats all you can ask of any manufacturer. I have found that any problems such as coils, reversing valves, boards, compressors, capacitors, txv'S...you name it...ALL The manufacturers face the same issues at one time or another. The fact is, I no longer see "junk" being made by any of the brands. Goodman has proven to be as good if not better in many cases than many of them. Also don't forget that most homeowners want the best price up front that they can get and Goodman is very reasonably priced although they are not the cheapest. Point is, they go with a cheap contractor that may not even be licensed. Why would you want to make an investment for thousands of dollars and have an idiot install it to save a few hundred dollars? That is usually (not always) the reason for equipment failure. All things considered, Goodman is a very good value...that is why I am so happy with them. Yes, I sell Trane, Lennox, Rheem and Carrier (Bryant) and others. I always recommend Goodman as the value leader. Their other brand, Amana has the best warranty in the industry for a few hundred more. Bottom line, Goodman bashers have in most cases had a bad experience due to inferior installation technique! A beautiful looking job is only as good as the installer and how he did it that day. It sucks I know, but thats the cold hard truth. I recommend you check out your contractor with the bbb, get referrals, do some research on proper installation and ask a lot of questions!!!
Location: new jersy
Years owned: 2
Satisfaction Rating:
Purchased two different units made by goodman -- Big Mistake. One Unit after 2 years the coil and condenser went the other unit after 2 years the coil went and then they give you the excuse well the installer should have told you about the insurance for repair cost. They know their product is deficient and don't care. Advice: buy anything but a Goodman.
Location: utah
Years owned: 2
Satisfaction Rating:
When looking to replace my ac unit I did plenty of research and found a lot of bs out there with regards to this brand. I knew all the big brands and felt like I was paying for the name and after looking into it I found that Goodman really was the best value. It wasn't the cheapest or most expensive but it has the best warranty out there and cost me less than a comparable Trane, Lennox or Carrier unit. People told me to not buy Goodman but I think I made the best choice...I Call them the Hyundai of the hvac world cause they kick butt on warranty and they back it up. Also I heard they are the biggest unit seller in the country to boot.
Years owned: 3
Satisfaction Rating:
"Goodman's Bad Coils"
In 2009, I bought two new 4-Ton Goodman a/c systems for my house and had them installed by a certified technician. Precisely after one year, one of the coils developed a leak, and a couple of months later, the other coil developed the same problem. The technician who replaced my coils was the same technician who installed the original units. According to him, Goodman continued using older coils which were designed for R-22 Freon on their newer units which "required" R-410A Freon. The newer Freon works under higher pressure, and is very corrosive, which could result in leaks if used on coils which were designed for R-22. I seriously think that a class action lawsuit should be brought on Goodman, in order to cover all of the expenses their customers have had to incur due to Goodman's recklessness. They had to have known this would occur. They probably ran the numbers, and it was too expensive for them to recall the units.
The opinions expressed in these reviews are the opinions of consumers that submitted reviews to FurnaceCompare.com. They do not necessarily represent the opinions of FurnaceCompare.com.


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Port & Company® - Ultimate Crewneck Sweatshirt. PC90
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