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Yes, The Red Demon is free. This is Book Four in my Daughters of Persephone series – my homage to the Space Opera.
Check it out right here -
There is a reason Tem is called the Red Demon. She does what she wants when she wants. No one controls her. Time and space do not hinder her. Worshipped on ancient Earth as a goddess among many people in many different lands, nobody opposes her, except her creations, Issa Bokinan and Kane Tirol.
Having left her own daughters behind on Earth as seed stock for future generations, Tem had hoped to make a life with Kane. That is not to be. Rejected, alone and broken, she seeks comfort in the past with the Empress Ya, on Persephone, promising to behave and keep her identity a secret. Tem is hard pressed to control her worst impulses when she's caught riding the Empress' prize stallion.
Horse Master, Aytan Kirrae, cannot believe his eyes. A small Red Woman has just ridden off on the stallion named for him, a horse bred for the Empress Ya. He waits for her return, flipping her over his knee, meting out what he thinks will be a kinder punishment than she would receive from the Magistrate. He has no idea the small Red Woman can kill him with a single drop of her blood.
Pulled along to the future against his will, Aytan thinks he's dreaming, until he must share the Blood Bond with Tem to save her life. Once he does, his own life will never be the same.


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William Shatner Urges Release of Ailing Elephant
What has actor, singer, and author William Shatner (Canada's triple threat) been up to since nabbing the Emmy for Boston Legal?
The "Priceline Negotiator" recently made a plea for the release of the Edmonton Zoo's lonely, ailing elephant, Lucy.
In a letter to Edmonton Mayor Stephen Mandel, Mr. Shatner wrote, "I humbly ask you to allow Lucy to retire to better circumstances than at the Edmonton Zoo … she's old, feeble, and many of us know how that feels."
He joins pachyderm protectors around the world in rallying for Lucy's release.
Two years ago, elephant expert Winnie Kiiru named the Edmonton Zoo the worst zoo in Canada for elephants and called for the closure of the exhibit. Edmonton's frigid winter weather and the zoo's policy of locking Lucy in the barn when the zoo is closed mean that she spends the majority of her time indoors. The short amount of time that Lucy is allowed outdoors is spent in a barren, dusty enclosure. Being forced to endure the cold and the forced immobility is fueling her arthritis and causing chronic foot and respiratory problems.
Please add your pleas to Mr. Shatner's by writing to Mayor Mandel. Urge him to release Lucy to a sanctuary that can offer her hundreds of acres of diverse terrain, ponds for bathing, a more suitable climate, and the company of other elephants.
Written by Karin Bennett
Commenting is closed.
Please hurry before too late. The cold winter is here. Even through Lucy's photo, I can see clearly Lucy is suffering from excruciating pain. Its unbearable to see. She looks so lonely and miserable. Torturing an innocent Lucy is totally senseless. Why the Moyer Can't feel it?
Lusy is being abusedmentally and physically. where are the animal rights people where Lucy lives. please save Lucy.
WTF? Jade where does it say that? I couldn't find any such thing did I miss it somehow?
Regardless what her illness are or not this is just wrong. We take these beautiful animals away from their natural free habitat and locked her away into a very isolated and lonely place. Please allow her the right to be living in a sancutary where she can live out the rest of her years happy with other elephants and being well taking care off. Please have a heart. Thank you.
Molar problems do not cause asthma which is a disease of the lungs. At least if you wish to support the cause at least get your health facts straight people.
This is a difficult issue more because because we can all accept the fact that animals are better off in their natural habitat rather than in zoos. Of course we cannot shut down all zoos because society just won't have it. This is beyond whether there should be elephants in Edmonton. This is just down to what do we do with Lucy now that she is here is old has arthritis a molar problem that causes breathing difficulties like asthma and would have a hard time travelling just the same. It seems that the zoo would not be entirely adverse to moving Lucy because they know she is old and would like to have her be around her own kind. The only problem is that she is used to humans and may miss them more than one would expect. Enough to be depressed and die just the same in the elephant sanctuary.
This is such a hard issue especially because you can always find experts to support both sides of the issue. I especially wish that the forefront people in this debate were veterinarians who are qualified to make these decisions rather than politicians and celebrities.
To Mr. Shatner and all the other great stars that use their voice to help all animals in danger. It renews my belief in celebs that all are not in it just for the fame and glorynow if we could get JLO to stop wearing and purchasing furs could we send her a tape before her children adapt the same lack of compassion for animals that have been murdered for their skinBut maybe she has changed her veiws since having children and expierencing that LIFE IS PRECIOUS NO MATTER WHOSE IT IS!!!! Bury your furs so the murdered animals can have their skin back!!!
Thank you Mr. Shatner!!! It's good to know people like you are aware of horrendous treatment of our animal friends.
Thank you Mr. Shatner your involvement in this will help bring attention to Lucy's plight.
That is so awful what theyre doing to poor lucy! i am totally behind william 4 getting her a new home!
Everyone should follow in the steps of William Shatner and email Mayor Mandel i have done just so Lucy needs to be taken out of there immediatly this beautiful ageing animal deserves better than this she dos'nt deserve to be left there to die a lonely death.
be merciful pls. release lucy.animals are like us they have feelingsflesh like us..ty.
Wow what a classy man. I'm very impressed with Mr. Shatner
This is so awesome..I have a new respect for him thank you!
I may not be a zoologist but I think that even I can figure out that Canada is probably not the greatest of places for an Elephant. Especially during the winter. Please do what is right for the animal. It sounds as if she has done her civic duty in the zoo now it is time for her to retire in peace.
Wise words William! We all deserve our creature comforts especially as we get on a bit.have a heart let her retire with dignity.
Dear Mr. Mandel I respectfully am asking for the release of the Edmonton Zoo elephant Lucy to live out the remainder of her life in a more suitable environment. Elephants have very complex social structures not unlike humans. They feel hurt and grieve and keeping her alone is like solitary confinement. And what is her only crime? Being an elephant in captivity. It is also not fair to keep her in a cold climate totally wrong for her adaptation. An elephant rescue site would be much better suited to her needs with the proper climate and other elephants for her to bond with. Please answer to a Higher Power and do what is right for one of His own Sincerely Dr. Carole Edmonds
Please allow Lucy the dignity of living her last years with her own kind. Just the chance to stand by the side of " one who knows" for even a day could lift the heart of an animal who has given patrons of your zoo years of education and enjoyment. Look outside the box of the financial world and give back to Lucy PLEASE! Sincerely CW
This is what I wrote to the Mayor and Councillors. Perhaps it will help you Dear Honorable Mayor Mandel I am writing on behalf of the elephant Lucy living at the Edmonton Valley Zoo. Please find it in your heart to allow a veterinarian from a sanctuary to examine Lucy and provide any necessary care so she can be safely moved to a sanctuary. She has given 29 years to the Edmonton Valley Zoo. Perhaps its time to give her something in return a chance to retire with others of her own species in a place we could consider a perfect retirement community if we were elephants. I understand that The Elephant Sanctuary in Tennessee would offer Lucy hundreds of acres ponds fresh vegetation and the company of other elephants. Thank you for taking the time to read my email. And thank you in advance for acting on Lucys behalf. Most respectfully Rosemarie Calabro
Thank you SO Much Mr.Shatner! I am a big fan of yours and even BIGGER now. This poor elephant needs to live in a sanctuary to be live happily and with companions so she isn't lonely.
Thank you Bill Shatner! Perhaps with your name attached the zoo will pay attention to this issue and do right by Lucy. And you will never be uh older you will always be the best of both Capt Kirk and Denny Crane. Thank you for speaking up for Lucy. I hope you have the time to see this important issue through.
William Shatner has also been a longtime advocate on behalf of horses.
There should be a petition for her removal?
I meant Edmontonian a typo.
I truly hope that poor Lucy is released Some of my meat eating friends went to that zoo and they said that the exhibit was horrendous. A concerned Edontonian
I just returned from Kenya and saw these magnificent creatures as God intended in the wildto make Lucy suffer this way is just another reason that being Canadian is embarrasment to me when it comes to the way we treat animals
More reason to love this man
Thank you!
Very eloquently put Mr Shatner wonderful that u took the time to try and make a change for Lucy. Lets hope it happens and people ditch their ego's and give her some quality of life..
please release the innocent animals from all these torture..
Thank you Captain Kirk! Always my hero!
Thank you! Elephants and me will never forget!
here is a link to Zoocheck Canada's face book page where you can send a letter asking for her release please! httpwww.facebook.compagesZoocheck118864269587?vapp133542302645
William Shatner great actor great man.
Thank you! Thank you! from Edmontonians!
Thank you for helping Lucy x
William Shatner We need more people in the world to be the animals voice more like you William Shatner keep being there their VOICE
Live long and prosper William Shatner! Mr. Spock would be proud…
am supporting this effort!
Thank you Mr. Shatner! Not only are you one of my favorite actors but you are now one of my heroes too!

subset: commoncrawl


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Topic: Open Flash chart in a partial template - how to?
I have been trying to get Open Flash chart to work in my partial template and everything i try just does not work.
Can somebody be kind enough to show a newbie where they are going wrong!
One of the problems is, in my controller I am not using the index action, i am using a separate action called by ajax.
So when my partial loads, the graph is activating the wrong action in the controller so I get this error...
ActiveRecord::RecordNotFound (Couldn't find Event with ID=graph_code):
controller code...
def graphresults
@graph = open_flash_chart_object(600,100,"/events/graph_code")
render :partial => "graphresults" , :layout => false
def graph_code
title = Title.new("MY TITLE")
bar = BarGlass.new
chart = OpenFlashChart.new
render :text => chart.to_s
and in my partial view....
<script type="text/javascript" src="/javascripts/swfobject.js"></script>
<%= @graph %>
Any help would kindly be appreciated


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The Chicago Loop Synagogue was founded in 1929 to serve the religious needs of those whose professional or business activities brought them to Chicago's downtown business district. Since then, it has grown to become the city's central synagogue. It is, in a very real sense, the symbol of the Jewish religious presence in Chicago. Citywide events of religious and other significance to the Jewish community are conducted in the Synagogue, and civic and religious leaders of other faiths look to the Chicago Loop Synagogue as a source of guidance and information concerning Judaism and Chicago's Jews. By providing a convenient place for daily worship, the Synagogue makes it possible for people from all parts of the greater Chicagoland area to make congregational prayer a regular part of their business day, as well as to observe Yahrzeit and to recite the Kaddish prayers during periods of mourning. Membership dues include the lighting of Yahrzeit candles and the recitation of Yahrzeit Kaddish prayers in memory of members' loved ones. Those whose activities bring them in or near the Loop, readily find it possible to take a few minutes to join in one of the morning, afternoon or evening daily services in the Bet Midrash of the Synagogue. Thus, it supplements the service of local congregations with which most of these worshipers are also affiliated and serves the unaffiliated as well. While the form of worship in the Synagogue is Traditional, and separate seating is observed during the morning Shabbat service and the first Mincha service Monday through Friday, all Jews, whatever their background or religious affiliation, are made to feel welcome at the Chicago Loop Synagogue. The synagogue also serves as a place of worship for the thousands of Jewish visitors to Chicago from all parts of the world who stay in the downtown area. Many of those who attend professional or trade association conventions and meetings held in Chicago, make worship at the Loop Synagogue a regular part of their visit. Over the years, distinguished leaders of Jewish communities in the United States, Europe and Israel, have worshiped at this Synagogue while in Chicago. In recent years, the construction of high-rise apartment buildings in and near the Loop has provided a residential population for whom the Loop Synagogue is the major religious affiliation. For these families, the Synagogue provides the customary services and facilities of any local congregation. Throughout the year, the Synagogue conducts wide-ranging educational programming. On a year round basis, there are daily mid-day Bible study classes and Saturday afternoon Torah study sessions. On the first Thursday of the month, there is a lunch and learn with Rabbi Stanley Kroll or a visiting Rabbi. There is a modest charge for the lunch and reservations have to be made a day in advance with the Synagogue office. The Chicago Loop Synagogue is justifiably proud of its famous annual Scholar in Residence program, where Jews of all denominations can join in a weekend of Jewish learning. Recent Scholars have included Rabbi Joseph Telushkin, Rabbi "Yitz" Greenberg and Dennis Prager. This past year's Scholar in Residence was Rabbi Avi Weiss. The Chicago Loop Synagogue is also an architectural marvel. Among other features, it contains the magnificent Abraham Rattner stained glass artwork which takes up almost the entire Eastern facade of the Synagogue, Rattner lithographs in the Bet Midrash and the entry to the Social Hall and the Hands of Peace by Henri Azaz, which crowns the entrance to the Synagogue. This year internationally acclaimed Cantor and Broadway performer, Dudu Fisher, will lead the High Holiday services accompanied by the Tel Aviv Lev-Ran Singers under the musical direction of Menashe Lev-Ran. Cantor Fisher, Menashe Lev-Ran and the choir set the proper tone of beauty, reverence and awe during this time of year.The Chicago Loop Synagogue has been fortunate to have Stanley E. Kroll as its Rabbi since 1977. Rabbi Kroll's Devrai Torah and sermons are meaningful, educational, enlightening, relevant and thought provoking, with a large helping of humor mixed in. They are often the subject of informal discussion at the Shabbat Kiddush, where the attendees enjoy the camaraderie of the Chicago Loop Synagogue. When the occasion presents itself, Rabbi Kroll prepares a delightful Shabbat Cholent Kiddush luncheon eagerly anticipated and enjoyed by all.
Read the Hanukkah issue of The Bulletin of the Chicago Loop Synagogue online!


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In her historical study of wealth and poverty in the early Church, Loving the Poor, Saving the Rich, Helen Rhee offers the following interesting historical tidbit with regards to how early Christians were able to minister to their imprisoned brothers and sisters who awaited martyrdom:
Bribing the prison guards, which must have cost a certain amount, features frequently enough in the Christian texts. The impressive visiting privileges and hospitality Ignatius [d. 110] enjoyed at Philadelphia and Smyrna with the local Christians and the delegations from three other churches were likely gained by bribery as well…. It apparently did not raise any moral qualms among Christians; rather, it constituted a necessary part of supporting the prisoners since it enabled the churches to maintain contact with them (and thus to tend to their needs) and allowed the guards to be more favorably disposed to the Christians. Thus the Didascalia (19) … ordered the community members to spare no efforts to procure both nourishment for the condemned Christian prisoner and bribes for the guards so that everything possible might be done for his or her relief.
For those who are curious, the text from the Didascalia, a third century Christian community manual, reads as follows:
You shall not turn away your eyes from a Christian who for the name of God and for His faith and love is condemned to the games, or to the beasts, or to the mines; but of your labour and of the sweat of your face do you send to him for nourishment, and for a payment to the soldiers that guard him, that he may have relief and that care may be taken of him, so that your blessed brother be not utterly afflicted. [italics mine]
While Rhee notes that bribery "apparently did not raise any moral qualms among Christians" in the early Church, no doubt readers today may not so easily approve of the above direction to make provision for bribing guards. How might we better understand this anomaly? What measure of prudence guided this practice? (more…)


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Runaway tuition should be reined in
A compromise has been reached on the student loan interest rate, according to the Associated Press. We'll see how it goes, but we're happy to be able to report that compromise is still possible in this Congress.
This debate touches on a bigger problem, however: Four-year university tuition is too high, especially at private colleges. Maybe the federal government, which is helping to pay for it, can use its leverage to lower the price tag.
It's like health care. The cost has increased so rapidly that the government's share of aid is becoming a budget buster. With health care, though, the federal government is trying to reduce runaway costs at both private and public health facilities. It's messy, but it's an attempt.
Like health care, there's no getting around that fact that university education is going to be expensive. It's very valuable, and it has substantial costs.
Nevertheless, the cost of a university education has more than doubled over the last 20 years, far outpacing inflation. It doesn't seem like that extra money has been used to improve the quality of the academics. What are the chances, for instance, that a class is taught by a graduate student or adjunct rather than a professor? It's more likely now than 20 years ago, judging by what we've seen, heard and read.
We're focusing here on private colleges. The biggest problem with federal student loans is that they relieve private schools of the need to compete price-wise. To a certain degree, these schools can charge what they want, and the federal loan programs can make sure they get it.
This is, essentially, a huge public subsidy of private education – while the public also pays for a parallel set of public universities.
State colleges are the ones the people as a whole have designated as affordable and have chosen to subsidize with our tax dollars. There are a wide range of them for students to choose from, in state and out of state. They're still expensive, but the public can weigh in on that somewhat through elected officials.
Many private colleges have plenty of money from endowments, alumni and television sports contracts, but they don't use much of that to lower tuition and offer scholarships. Instead, they rely on public loan programs.
What if the federal government said, "We won't loan students money to go to any college with tuition higher than X"?
What if it also required each school to offer a certain proportion of academic scholarships – serious ones, not just a couple thousand dollars – before issuing student loans there? Such scholarships were once widely known as a ladder to success; they also were an incentive for high schoolers to work harder, a brass ring to reach for. Now they're mostly gone. It seems like almost all merit-based scholarships today are for athletics. Scholars must rely instead on need-based aid, mostly loans they'll have to pay back for most of their adult lives.
If the government did these things, our own Paul Smith's College might come out better than most. Its tuition for 2013-14 is $21,930 – high, but much less than many private schools. Columbia in New York City, the most expensive undergraduate college in 2012-13, charged $47,246, according to U.S. News & World Report. The top nine charged more than $45,000.
There's a lot of fat for such schools to trim, if it comes to that.
Start with presidents. Dozens of U.S. college presidents make seven-figure salaries. In 2011, the Chronicle of Higher Education reported that Mountain State University in West Virginia paid its president a whopping 3.5 percent of the entire college budget – $1,843,746. Even public universities pay their presidents a median salary of more than $400,000, according to the Chronicle.
This is outrageous, given that student debt is such a national problem.
Many schools also spend way too much on sports and buildings, which lure more students and more money, taking advantage of recruits and alumni donors being awed by beautiful architecture and winning teams. Unfortunately, it's often hard for prospective students to see much of how well a school actually educates until after they've taken out a loan.
It might be a good thing for certain kinds of private colleges to find themselves ineligible for federal student loans. We suspect they'd solve the problem quickly enough on their own.


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Skip to comments.Birthday President G.W.Bush cousin to Obama, & Cheney & Romney too! Are we already under a Dynasty?
Posted on 07/06/2013 9:03:06 PM PDT by lee martell
I certainly miss having a President I can respect and admire without holding my hands over my eyes. Former President George W. Bush turns 67 today! Like many conservatives, I wish he was still president, maybe just under the guidance of someone other than a certain Karl Rove, who discouraged President Bush from pushing back on the incredible level of disrespect the left dumped on him for eight long years. I can only wonder what it means that this many influential people are from the same family line? It's amazing when you think about it all, but quite true. The Bush family is related to Obama, they are cousins 11 times removed. I already knew that the Bush's were related to John Kerry. I recall thinking during the 2004 campaign, how can Kerry be so cruel to his cousin? However, I figured that the potential power of holding the presidency would easily trump any flimsy family ties. All I can figure is wealthy families tend to marry other wealthy families, so the money remains somewhat concentrated within certain professions and certain organizations run by those families. Still, It's a little disconcerting, to be more or less 'owned' and utilized by just a few family lines, even today. I think the 'most friendly and trustworthy' John Huntsman is also related to the Romney line. And the beat goes on.
If you have family dating to colonial times chances are you are related to others who can date that far. I am related to Bush through the Bollings, who happened to be a most fertile family.
W is a class act, but lets drop the rose colored glasses act.
Heck, we're probably all cousins 11 times removed. Or maybe even 10.
Uh, no, we're not under a family dynasty even if several leading politicians are distant cousins. Being somebody's 11th cousin does not a dynasty make.
The worst dynasty we are under is that of a ruling elite. It wouldn't matter if none of them were related, or if all of them were distant cousins. The problem is that the little people in America have been taken over by a distant elite that is running roughshod over "we the people".
Sorry, meant that for other Bush thread.
Hope you're wearing your nomex suit.
GW moved us closer to the left and closer to totalitarianism. Wish I could take back my first vote for him.
I think there are very few people here who had no problems with GWB and what he did. Patriot Act. Idiot SCOTUS attempted appointment. DHS. TSA, and officerizing glorified baggage handlers - and now molesters. On Obama's request beginning QE1.
You can be related to anyone on Earth at around 40th cousin, so 11th cousin isn't impressive.
"We the People" elected Obama. Ain't populism great, retards?
Add on medicare part D, and you've got one heckuva list.
Universal suffrage rocks!
We are all suffering from universal suffrage. I am sick of all the populist BS that believes that the same low information sheeple who brought us Obama are not representative of the popular will. They ARE the popular will which is the problem.
Yeah, and don't forget when he slammed those brave American Patriot volunteers, 'The Minutemen', who were trying to protect our southern border, 'Vigilantes'. Or that the muzzies were just really a 'Religion of Peace' comment of his. Good God.
11?! Seriously?! That is an extraordinarily distant relationship.
Pick two random people on the street. They're typically at most 7 times removed.
And he's coming out in favor of the current version of "immigration reform", the amnesty BS he couldn't get passed.
We have Obama as president because voters were reacting to the disastrous presidency of Bush.
I am sure that we can review Mark Twain's suggestion to 'enlarge' the franchise, giving extra votes to those who have more money, or more college degrees and have a little laugh.
There are a lot of posters that I think of as being very wrong. I do think that denying them the franchise is probably the wrong path to follow, as it can be used against good people as much as it can be used against bad people, and perhaps more.
For what ever it is worth, and I am not bragging - I can trace my "lineage" back to John and Priscilla, who arrived on the Mayflower, many moons ago.
So what, big freaking deal!
It doesn't make me any more worthy a human being than the latest legal immigrant, who went through far more paperwork and hassles, than my forbears ever had to endure, to obtain his/her citizenship!
Me and thousands of John and Pricilla's other descendants, wanted a better life, and we are the beneficiaries of their bravery - to risk the high seas and the difficulties of crossing the Atlantic, to face an untamed wilderness. So those of us who can trace our ancestry back to them have nothing to brag about.
Would we now take that risk?
Striking out for the "new world" wasn't for the faint of heart then, so why now do we coddle newcomers as if they are incompetent, unable to care for themselves, learn the language, adapt to our laws and freedoms, so needing endless generations of our tax-payer support.
Why are we now so worried, afraid, intimidated, trying to figure out how to find a way to escape the tracking of the IRS, FBI, ATF, TSA, NSA, HSA, and assorted other alphabet agencies.
It took John and Priscilla no more courage than it took the MacPhersons, O'Brians, Napolitanos,Eckstroms, Phaths, etc. & any of the other immigrants from foreign lands who came to AMERICA so they could be free. But, our government cripples the newcomers, instead of giving them the freedom we all enjoyed, to strive on our own. So the "helping hand of liberalism strikes again", enslaving and suffocating them, then turning them to the dark side of learning how to manipulate the "system".
All left their homeland, praying for a better, freer future. I am ashamed of how their hopes for the future are being destroyed by our non-sensical government fallacies, and our citizens failing to comprehend the difference between teaching a man to fish, versus giving him a plastic card, so he can get in line to claim his daily fish once he gets to the .gov "fish window". (and we all know those fish stink, because of all the many hands they have to go through.)
I respect all legal, whether they be Welsh, Scots, Irish, Italians, Germans, Vietnamese, Cambodians, Koreans, etc, for they all came here for a better life.
A life where they could work hard, exercise their talents, and raise their children to strive harder and higher to become everything they could attain.
Grandsons of illiterate immigrants have graduated from MIT, Harvard, Stanford with honors.
We forget that only little more than half a century ago that many bright and talented people left school in the third grade, or the eighth grade. They were needed to work, to help their families get ahead.
Many of them, despite a lack of formal schooling, used their talents, lived good lives, created solid businesses, and raised intelligent and productive families, and children who fulfilled their dreams.
They are just as much as worthy of honor and recognition as those of us who came a bit earlier, for all of our immigrant parents hoped that hard work would offer a better life for their children and grandchildren.
That said - our present immigration policy is sentencing illegals to failure, and I just can't wrap my head around what our elected idiots are trying to accomplish.
We now live in "interesting times", where we must be careful about what we say, right?
Obama IS Bush on steroids.....
Yes, pick any two random people on the street of a small town, and they will typically be related at most 7 times removed.
I am a hobby genealogist, and have identified by name roughly 5,000 people in my mother's family tree, alone (I estimate that there are another couple thousand "missing.") There are several fair-sized towns in Redwood County and Brown County, MN - towns I've never visited, incidentally - where I would be third-, fourth-, fifth-, and sixth-cousins with a large percentage of the people I met randomly on the street. (Being a sixth-cousin means that one has a pair of great-great-great-great-great-grandparents in common with the other person.)
My most-interesting observations about my family tree:
1) Lots of people in the U.S. are born, grow up, and die within 100 miles of the same spot. This was especially true of my grandparents', great-grandparents', and great-great-grandparents' generations, but even of my generation, unbelievably many maintain residency in the same corner of the state (apart from their college days, etc.).
2) Americans of Scandinavian descent are remarkably long-lived.
3) After a while, most obituaries become boringly similar (Note to self: Write your own obituary while you still have the time!).
4) Establishing a "dynasty" requires - besides herculean efforts - that the members of that nascent dynasty be aware of and have agreement on what they have set out to do, but it is possible to achieve and maintain "super-wealthy" status by dint of one's collective efforts - by essentially forming a "family syndicate." The main barriers are a) divorce, and b) the resultant dispersal of wealth to non-family members (step-relatives). (However, the one instance of success I've identified in my own extended clan was founded in the gray beginning on what would be considered today to be a grossly unethical act.)
Your posting is very well stated and capsules the issue.
Same thing.
I, too, am a Bush cousin. But think about it: anybody whose ancestors were early American settlers, as the Bush family ancestors were, is likely to be related to other descendants of early American colonists. There were so few people — and they had such large families — that it's not in the least bit surprising. So the Bushes and I share one set of many greats grandparents, big deal.
Oh Geez, we have George Walton, one of the signers of the Declaration of Independence in our family.
"If you have family dating to colonial times chances are you are related to others who can date that far. I am related to Bush through the Bollings, who happened to be a most fertile family."
I wonder if Eric Bolling, on Fox News Cable TV (The Five and Cashin In) is also related to Bush and you.
Y'all should be happy. I have a branch in my family tree that leads to none other than former WV Senator "sheets" Byrd! Talk about embarassing...
I do not desire Bush back- any Bush. We would not be any better off with Bush now than we are with the kenyan. Bush would get more of hiss own brand of socialism through the Congress than the kenyan is getting and the logic of the situation and his previous Acts suggests he would have given us full on Single Payer Bushcare by now.
It is a family dynasty. All Presidents except for one(Van Buren) are descended from King John of the Magna Carta Robin Hood fame.
There were not that many people here during the 1600's, so the families that were here are possibly related to most of the population back then. I know I am. I'm even related to Hugh Hefner, whose family goes back to Gov. Bradford, as mine does, and probably the Bush family, and even the (ugh) president's mother's family.
Certain organizations have already selected the next president we just don't know it yet.
Don't know what organizations but bet you have to be a made man to know.
"Wish I could take back my first vote for him"
I wish I could take back my second vote for him. It appears I'm a slow learner.
As near as I can tell I'm not related to any of them and damn sure wouldn't admit it if I was.
My clan tended to stay out in the mountains, where I wish I was now.
I'm not related to any of them. I go back to a Jacob Urban who arrived here in 1753, fought in the American Revolution and moved to Pike County. You can watch every ten years in the census and watch the name move westward down the coal strip in Pennsylvania. Nobody is a relative of Obama, Bush or Kerry. Thank Goodness!
You may have a point there, I probably should have reversed the two statements, logically speaking. Some more of my ADD tendencies shining through...Oh look! a grey squirrel eating a raspberry!!
You should be and rightfully are proud of your Mayflower ancestors. Lucky for you the records are available and accurate. Can you imagine how scary I must have been to literally leave everything behind like that? The fact that many left due to political oppression served as a catalyst, but one still needed to be strong to do this with any modicum of satisfaction. The closest we may get to that kind of Marco-Polo courage is going to be maybe 15 years from now, when the man who owns Virgin Air has raised enough money to start the first colony on Mars. He will provide for your one way ticket to Mars. Your space ship will be designed to disintegrate once you reach the red soils of the Martian lands. I probably will NOT be among the first ten people.
Nothing much to be proud of, really. I didn't pick them, and there must be millions of us that have descended.
I was just lucky enough to have been able to trace it back. And, for whatever it is worth, there are a lot of disreputable apples in the old family tree.
One the other side of my father's family, (Scots) - had to leave Scotland at night, rowing out to a boat - one step ahead of the English - had something to do with "The Clearances" and disobeying the law.
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Yesterday, in a deadheat, TeaChatters were split on whether they had blended their own teas (and/or created a Signature Blend) or not. You can still vote and discuss yesterday's topic.
Welcome one and all to TeaDay, brew some tea and come share what is in your cup today..all day! Make sure you check out what other TeaChatters are drinking as well. You can also reflect back on your TeaDay if you need to.
Today's TeaPoll and discussion topic is positively negative! What is the singular WORST tea you ever had the displeasure of trying, not including the random bad cup out somewhere...this is a tea that you either purchased or received as a gift. What happened to it?
I will see YOU on TeaDay! Bottoms up...refill!!!


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Cleveland Independent blonde Escort Listings ( 1 Listing Total )
Cleveland Independent Escorts Reviews
Lisa Lynn
Lisa was very nice on the phone and we booked something for that evening. I showed up at her place and she welcomed me in with a nice hug and kiss. We took care of things and I was very impressed by her.
We got more comfortable with one anpother and she started to give me a great massage that got me very hard. She took her clothes off and gave me an amazing BBBJ. Before I popped I wanted to bang her. So we started with missionary and then doggy. I wouldve loved to COB but loved doggy too much.
Awesome SP and will probably see her again.


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Set up and store session settings in reusable templates to jump right to your custom configuration during pre-show activities.
A timesaver on every level. Configure M/Es, LiveSet shots, transitions, media players, and more with your most frequently used setups and content. Presets include multiple slots for instant access to your preferred assets, even while live.
Use the UI to link switcher and M/E source rows together in color-coded groups to streamline your simultaneous actions on multiple sources and multiple outputs. Make instant, accurate adjustments and fewer mistakes.


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Research Fellowships and Programs
As a nationally-recognized center for historical research, the Massachusetts Historical Society fosters a strong sense of community and actively supports scholarship on the history of Massachusetts and the nation.
The Range of Our Activities
The breadth and depth of the MHS collections are an inspiration to researchers, and this is reflected in scholarly programs. Some programs reach beyond the familiar strengths of our collections to build on holdings in 20th century political or environmental history, for example. Other programs help us to develop a deeper understanding of Massachusetts or national history by representing topics beyond the scope of our repository.
Our Relationship with the Profession
MHS staff and colleagues at local universities work together to develop a wide range of MHS programs. Faculty members from Boston College, Boston University, Harvard University, MIT, Northeastern University, and many other academic institutions serve on program committees and actively participate in seminars and conferences.
What We Offer
All of our programs are designed to meet the needs of scholars at every level of their career, from graduate students to new faculty and tenured professors, as well as public historians and independent researchers. These programs include:
Fellowships to support research visits to the MHS library and collaborating institutions
Seminars and brown-bag lunches where scholars can present their research, network, and learn what others are doing
Conferences where they can explore topics in-depth
A Research Fellows Alumni Network through which fellowship recipients can maintain an ongoing relationship with the MHS
The Peter J. Gomes Memorial Book Prize to recognize excellence in historical scholarship on Massachusetts.
Every year, hundreds of scholars from throughout the country take part in these and other programs, including the annual Graduate Student Reception in September. We invite you to take advantage of the services that we have developed to meet your specific needs.


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|< back
|Alpine Skiing - Varsity Boys USSA/Tristate: U18/U21 - Schaefer Cup
|Event Type:
|January 5, 2013
|see recap
Event Recap:
The Berkshire Ski Team kicked off the second semester with 12 athletes competing in the Schaefer Cup, a USSA/Tristate slalom race for U21 and U18 athletes (U16 skiers were also invited to compete up in this race) held at Berkshire East (Charlemont, MA) on Saturday, January 5th, 2013. Among a field of 96 young men and 78 young women, drawn not only from prep schools like Deerfield, Northfield-Mount Herman and Berkshire but also ski academies, such as Stratton Mountain School and Green Mountain Valley Academy, and even colleges like UConn, Umass and St. Anselm's, Berkshire athletes made an excellent start to the 2013 season.
On the girls' side, the course proved challenging for our young but talented team. Our top performer was Julia Slyer '14, who finished 20th overall, and 9th for her (U18) age group; sophomore Krissy Goversten '15 finished 30th overall and 20th among the U18's. Making the biggest advance, newcomer Caroline Slyer '16 raced up from her ranked position of 70th to finish 35th overall, and 6th for her age group (U16). In another huge move, Annette Key '16 moved from 72nd into the 40th spot overall, which was 10th for her age group (U16). Rounding out the U16's, Samantha Reagan '16 moved from 66th to 52nd overall, and 13th for her age group. One especially notable achievement came from Emily Barclay '15, who fell on her first run, "hiked" up to make the gate and was thus allowed a second run: then, though starting in last place due to her fall, Emily mastered the course and finished with the 8th best time on the 2nd run, landing her in 54th overall for the race. Elise Chauvel '15 and Eliza Stitchter '16, two very talented and promising athletes, were knocked out of the competition early after falling on the first run, as sometimes happens to aggressive, competitive skiers at all skill levels—we look forward to strong finishes from them in coming races.
Our boys delivered excellent performances across the roster. Team Captain Jackson vanZon-Borwick '13 skied cleanly and fast, finishing 2nd overall and 2nd for his age group (U18), bested only by a ski academy athlete, Ryan Mooney (U18), who is also a member of the US Ski Team Training Squad (we congratulate Ryan on his win!). Following Jackson, Nathaniel Mackenzie '14 turned in two very strong runs to finish in 3rd overall and 3rd for his age group (U18's). George Frick '14 refocused and rebounded after a rough first run, to finish in 27th overall, and 11th for his age group (U18). Close behind him was Bryce Schuler '15, who finished 29th overall and 7th for his age group (U16). Landing all four of our boys in the top 30, among a competitive field of almost 100 high school, ski academy, and college athletes, is a great start to the season!
Our next race is the first of the season for the Brigham Ski League (BSL), to be hosted by Salisbury School at Butternut (Great Barrington, MA) on Wednesday, January 9th, 2:30 pm. Boys' and girls' Varsity as well as Junior Varsity teams will compete.
*If you tweet, we invite you to follow the Berkshire Ski Team on Twitter at @BerkshireSki.*


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by Anton Shilov
Advanced Micro Devices on Monday officially closed its manufacturing-capacities spin-off deal and become fabless chip manufacturer. The move will allow the company to stop investing into new leading-edge foundries and process technologies, but will also mean that the company will cease to be fully-integrated chipmaker and will have to rely on manufacturing capacities owned by The Foundry Company.
"With the close of this historic transaction, AMD and its committed partners have conceived two strong industry-leading companies capable of charting future courses that will dramatically improve the technology industry," said Dirk Meyer, president and chief executive officer of AMD.
Manufacturing capacities of AMD from now on will belong to the company temporarily known as The Foundry Company (TFC). AMD will own approximately 34.2% and Advanced Technology Investment Company (ATIC) will own approximately 65.8% of TFC's fully-converted common stock. Still, AMD and ATIC will each have equal voting rights at the close of the transaction. ATIC's fully converted ownership may increase over time based on the differences in securities held by AMD and ATIC, and depending on whether AMD elects to invest proportionately with ATIC in future capital infusions to support The Foundry Company's growth.
TFC has a total enterprise value of approximately $4.3 billion, consisting of AMD's contribution of manufacturing assets and liabilities, (including its fabrication facilities in Dresden), intellectual property and employees valued together at approximately $1.8 billion; ATIC's contribution of $1.4 billion in new capital; and approximately $1.1 billion of debt assumed by The Foundry Company from AMD;
AMD received $700 million from ATIC for a portion of its ownership interests in TFC, the latter assumed responsibility for the repayment of approximately $1.1 billion of associated AMD debt, and Mubadala Development Company of Abu Dhabi paid AMD approximately $125 million for 58 million newly issued AMD shares and warrants for 35 million additional shares. As a result, AMD improves its cash position by approximately $825 million and will appoint a Mubadala designee as a member of its board of directors.
AMD claims that by spinning off its manufacturing capacities it not only reduces its spending on new fabs and process technologies dramatically, but also enables the whole industry to take advanced of its forty years of expertise in semiconductor manufacturing.
"Our 'Asset Smart' strategy is about more than providing AMD with long term access to world-class, leading-edge semiconductor manufacturing that is foundational to our growth strategy. It is about transforming the industry. ATIC is the ideal partner to help scale AMD's forty years of semiconductor expertise, and provide a manufacturing foundation for the entire industry to produce the next generation of semiconductor innovations," said Mr. Meyer.
The Foundry Company will operate fabs in Dresden, Germany and will eventually build a fab in New York, USA. The company will use microprocessor-specific process technology to product AMD's central processing units as well as bulk fabrication process to make chips for other developers, including ATI, graphics products group of AMD.


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Home > The College > Cadet Life
The goal of the Cadet Life Program is to assist the cadet in developing the social and life skills that will help them throughout their lives. VFMC offers character, religious, social, and physical programs to assist the cadet's development as a whole person. In addition to their regular academic schedules, cadets are offered numerous clubs, activities, and honor societies, providing further opportunities to develop and pursue personal interests.
The Department of Student Activities (DSA) is committed to ensuring that each cadet at Valley Forge has the opportunity to participate in a myriad of extra-curricular activities.
The Valley Forge Military Academy & College Corps of Cadets is considered to be a cadet run Corps, with adult oversight.


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SilentChaos wrote:Glad to see everyone enjoying the teas.
I've been reading all the posts and following everyone's opinions and preferences. It might be interesting to note that the Lishan: Fushoushan and to a lesser extent the ShanLinXi: Long Feng Xia are classic examples of greener gaoshan oolongs, minimal oxidiation and roast with high fragrance. The flavour and aroma is all up front. An even better example of this greener style of gaoshan would be the bonus DYL. The Lishan: Cui Luan, in contrast, is slightly more traditional in style - heavier oxidation with a constrained but noticeable roast. The meat of the tea shows up in the aftertaste and hui gan. (A tea like this should get better after spending sometime stabilizing.)


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13406 E. Philadelphia St. Whittier, CA 90608
Three recent Whittier College graduates have been granted highly competitive Fulbright English Teaching Assistantship awards. The recipients Carlee Shults '14 (Avondale, AZ), Elizabeth Cook '14 (Zionsville, IN), and Amiya Moretta'14 (Seal Beach, CA) will each be spending at least 20 hours a week teaching English at their assigned foreign school and will also conduct side projects.
Shults, a sociology and Whittier Scholars Program (WSP) double major, is headed for the coastal, Eastern European country of Croatia; psychology major Cook will be in Mongolia; and Moretta, a WSP major, will be in Sri Lanka.
As the former president of the Urban Agriculture Club, Shults will use her gardening skills to create a food forest with her students, in tandem with her teaching responsibilities. She hopes that the food forest, which is a form of native habitat rehabilitation through edible gardening, will give her and her students an opportunity to explore cross-cultural connections through local agriculture and food.
"I have never been to Eastern Europe and greatly look forward to the rich and diverse peoples, foods, and languages I will encounter," said Shults. "I'm excited to represent the college and the country to the best of my ability, with honesty, compassion and perspective."
Moretta previously studied in Sri Lanka through the Intercollegiate Sri Lanka Education (ISLE) Program, and is eager to return to Sri Lanka to teach English and build upon her prior experience there.
"I wanted to go back and immerse myself deeper into the culture," she said. "I will be teaching English at a Sri Lankan university, with a focus on creative writing as an outlet for self-expression. I am most [excited for] the cultural exchange and the connections I [hope] to make with the people there."
Cook previously conducted field study research on the production of tea and its role in society in Nairobi, Kenya. She decided to apply to Mongolia after seeing a fascinating exhibit of the diverse country during a field trip to the Annenberg Museum led by psychology professor Christina Scott.
"I feel I have been given a gift and I intend to make the most of every opportunity," said Cook. "The professors [at Whittier College] made it possible through their diligent instruction. They made me hungry to learn more."
Moretta agrees, "I had a ton of support from many professors, such as Professor Jake Carbine who encouraged me to challenge my comfort zone by doing the ISLE Program; [English Mellon fellow] Michelle Chiharra who guided and encouraged me in my last semester of college to pursue a career as a writer; and of course, Director of Fellowships Rosemary Carbine, who helped me through the whole fellowship process. I also enjoyed my poetry class with Professor Tony Barnstone who was a joy to be in class with and a great source of guidance and encouragement in the creative process."
"Whittier College made it possible to do it all," Shults said, "so I feel prepared to conquer whatever lies ahead. I know that I have been offered every resource to succeed, and I have a powerful network of mentors and friends to guide me."
The Fulbright Program, established in 1946 by the late U.S. Sen. J. William Fulbright, is the flagship international educational exchange program sponsored by the U.S. government. It is designed to increase mutual understanding between the people of the United States and of other countries.
Elizabeth Cook '14
Hometown: Zionsville, Indiana
Fulbright Location: Mongolia
Major: Psychology
Study Abroad: Nairobi, Kenya
Internships: Intern in the Office of Communications, Instructor Guard at the Whittier Summer Sports Camp
Future Plans: To further her education and contribute to society
Amiya Moretta '14
Hometown: Seal Beach, CA
Fulbright Location: Sri Lanka
Major: Recording Culture (Whittier Scholars Program)
Study Abroad: Sri Lanka ISLE Program
Fellowships: Keck Undergraduate Fellowship
Future Plans: To use creative writing as a means for social change
Carlee Shults '14
Hometown: Avondale, Arizona
Fulbright Location: Croatia
Major: Anthropology/Sociology, Gender and Identity Studies (Whittier Scholars Program)
Study Abroad: China (JanTerm)
Fellowships/Internships: Richard M. Nixon Presidential Inauguration Fellowship, National Science Foundation Research Experience for Undergraduates (REU), Keck Undergraduate Fellowship, Poet Intern for the Center for Engagement with Communities' Mentor Program Coordinator, Academic Coach and sociology tutor at CAAS, president of the Urban Agriculture Club
Future Plans: Become a Teach for America Corps member and complete a master's degree in education from Arizona State University


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Go Zero Waste At Your Next Event
Zero Waste Is Not Waste Management – It Is Resource Management (Source: Eco-Cycle) A bit of a misnomer, "Zero Waste" doesn't just involve diverting as much o...Read More
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Canvas Check Clutch Bag
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Jim Cramer: Buy Stocks, Not Election Themes
Do we really have to start the fiscal cliff drumbeat immediately? Or can we just stipulate that at some point we will be down 1,000 Dow points, maybe more, before anyone acts to bridge it?
I want to approach the cliff discussion in three serial ways, the order that will define the stock market.
First, we had an election last night. It was definitive. There's no disputing Cleveland votes. There were no hanging chads in Florida. In fact, despite the big swath of red in your face, it wasn't even close. That's right, I repeat, it wasn't even close. The way election coverage unfolds is per se close, but let's just imagine that Ohio, Pennsylvania and Virginia closed at 7 p.m. and could tally instantly. We would have been in bed at 10 p.m. It's the way news is filtered that it seems so close. I wrote the lead story in the Harvard Crimson about how Mississippi put Carter over the top in the 1976 election. It seems silly right now, I mean, did Colorado put Obama over the top? Who cares? He went over the top by a wide electoral margin and you may hate that we use electorals but, as they say in sports, that's all she wrote.
Given that we have a resolution, we can't sniff at having a resolution. We are therefore better off than we were yesterday when there was plenty of news about how we won't have any resolution.
Second, given that we have seen this tableau before, like the last four years, we can't presume that we are going to see a wholesale repeal of prices. What's the point? The Romney boomlet, and that's what it was, impacted coal. It didn't even impact oil. There weren't a heck of a lot of stocks that ran in anticipation of a Romney surprise even as the Romney people on air at CNBC seemed mighty surprised and like Josey Wales in "The Outlaw" of the same name, they didn't want to believe the war was over and were still declaring victory.
Maybe they will sell their coal stocks today.
Third, the focus has to be on earnings, not fiscal cliff because fiscal cliff is that kind of binary, risk-on, risk-off garbage that people who don't want to do the homework on individual stocks get to throw out. How I wish I had that luxury, but I co-manage a charitable trust, have a lightening round and have prided myself not on saying "the national league will win the series," but on picking the team that does, because, ultimately, no one wagers on the National v. the American league except people who are too lazy to find out who is playing.


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Trend Alert: Floral Home Decor
The dark walnut island is a workhorse not only from the standpoint of everyday kitchen duties but also from a design perspective. Its dark color contrasts with the white cabinets and backsplashes, providing a visual anchor. The finish also acts as a transition from the cabinets to the Brazilian-walnut floor.
A hefty refrigerator is easily accessible to everyone. The cook can remove fresh ingredients and place them on the island opposite, and hungry passersby can grab a snack or a beverage without invading the primary work area. Thanks to custom panels, the appliance blends in with the cabinets.
Design Trend Forecast: Japan


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Infamous Crimes: Charles Manson, his Family and the Tate-LaBianca Murders
The hippie culture of love and innocence was brought to a brutal end on August 9, 1969 by Charles Manson and his Family. In an effort to ignite a race war he referred to as Helter Skelter, Manson instructed some of his followers to brutally and gruesomely murder a number of innocent people. Because some of the victims were celebrities and the violent nature of the crimes, there was a great media circus. Manson and his group were finally caught, tried and convicted, and most remain in prison to this day. In this video, WatchMojo.com learns more about Charles Manson, his Family and their infamous crimes.


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IGF signals in GIST
|Posted by Julie Royster (juliecontent) on Jan 30 2009
|GIST In the News >>
Insulin-related growth factor family: potential role in GIST
Several 2008 papers suggest that the insulin-related growth factors and associated receptors may be treatment targets for GISTs, including wild-type adult GISTs as well as pediatric GISTs and Carney Triad. This is exciting because development of drugs relevant to the insulin-related growth factor (IGF) family is already underway.
Background on IGF Family
The IGF family includes two growth factors (IGF-1 and IGF-2, sometimes called IGF-I and IGF-II), two receptors (IGF-1R and IGF-2R), and six binding proteins (IGFBP1-6) that modulate the actions of IGFs by keeping them bound in the bloodstream and therefore unavailable. The receptor IGF-1R can be activated by either IGF-1 or by IGF-2 to result in cell growth (proliferation) and resistance to cell death (apoptosis). The receptor IGF-2R does not trigger signaling, but rather serves to take IGF-2 out of circulation.
In normal physiology the IGF family is involved in childhood growth, puberty, pregnancy, and lactation (breast milk production). IGF-1 is produced primarily by the liver as an endocrine hormone (circulating in the bloodstream), but it is also produced in target tissues in a paracrine/autocrine fashion for local signaling. Most body cells express the receptor IGF-1R and can be affected by IGF-1, especially cells in muscle, cartilage, bone, liver, kidney, nerves, skin, and lungs. In addition to the insulin-like effects, IGF-1 can also regulate cell growth and development, especially in nerve cells, as well as cellular DNA synthesis. IGF-1 is produced throughout life. The highest rates of IGF-1 production occur during the pubertal growth spurt. The lowest levels occur in infancy and old age. (see wikipedia pages on IGFR-1 and IGF-1.
The IGF family is closely related to the insulin signaling system (insulin and the insulin receptor) that controls metabolism. In fact, IGF-1R can be activated by insulin. Hybrid receptors also exist that are a combination of half insulin receptor and half IGF-1R; these can be activated either by insulin or by IGF-1 or IGF-2.
Figure 1. The IGF system components. This figure is reproduced with the kind permission of the authors and Molecular Cancer Therapeutics from the paper by Sachdev and Yee (2007) in Molecular Cancer Therapeutics 6(1): 1-12.
The IGF system is composed of three ligands: IGF-I, IGF-II, and insulin. IGF-I and IGF-II are found in the circulation complexed to a family of binding proteins, called IGF binding proteins (BPs), which serve to regulate bioavailability of these ligands in the tissues. There are multiple receptor conformations. IGF-IR is a transmembrane tyrosine kinase and consists of two alpha-beta chains and has high affinity for both IGF-I and IGF-II. The insulin receptor (IR) mediates the effects of insulin. Two isoforms of IR, IR-A and IR-B, are found in breast cancer cells, with IR-A being overexpressed in many cancers. In addition, hybrid receptors assembled with one alpha-beta chain of IGF-IR (IGF1R) and one alpha-beta chain of IR-A or IR-B also exist. Arrows, ligand specificity of the various receptors; solid arrows, high-affinity binding; dotted arrows, low-affinity binding. Thus, IGF-I binds to IGF-IR and IGF-IR/IR-B with high affinity (solid white arrows) and to IGF-IR/IR-A hybrid receptor with much reduced affinity (white dotted arrow). IGF-II binds to IGF-IR, IR-A, and hybrid IGF-IR/IR-B and IGF-IR/IR-A receptors. For simplicity, only signaling initiated by the activated IGF-IR is shown. Activation of IGF-IR results in phosphorylation of adaptor proteins belonging to the IRS family or SHC. Activation of IRS and SHC leads to activation of extracellular signal–regulated kinase (ERK) 1/2 of the MAPK cascade via the growth factor receptor binding protein 2 (Grb2)/Sos/Ras/Raf/MAPK extracellular signal–regulated kinase kinase (MEK) pathway. IRS proteins also bind to the p110 subunit of phosphatidylinositol 3¶-kinase (PI3K), leading to the generation of phosphatidylinositol3,4.5-triphosphate (PIP3) and phosphorylation of Akt by phosphoinositide dependent kinase (PDK1). Phosphorylation of Akt leads to subsequent activation of mammalian target of rapamycin mTOR), eukaryotic translation initiation factor 4E (eIF4E), and p70S6 kinase (S6K). Activation of these downstream signaling pathways leads to enhanced proliferation, survival, and metastasis in cancer cells. Similar signaling pathways are activated by IR and the various hybrid receptors shown.
Several different types of cancer have previously demonstrated activity of the IGF family, which serves both to increase cancer cell proliferation (cancer growth), and to inhibit cancer cell apoptosis (cell death). IGF pathway activation can reduce the ability of some cancer drugs to cause apoptosis. IGF-1R is also involved in cell motility and anchorage-independence (the ability of cancer cells to leave the tumor and travel in the bloodstream to cause metastasis). Loss of IGF-2R in tumors effectively increases signaling by IGF-2.
IGF family signaling has been implicated in several types of sarcomas (Magenau and Scheutze, 2008, PMID 18525335; Scotlandi and Picci, 2008, PMID 18525338). Phase II trials of IGFR-1 inhibitors are in progress for Ewing's sarcoma, osteosarcoma, and rhabdymyosarcoma. Side effects may be minimal as long as inhibition of the structurally similar insulin receptor can be avoided; otherwise a diabetic condition could result. The existence of "hybrid" receptors complicates drug targeting. Alternate strategies include targeting IGF-1 and IGF-2 instead of the receptor, as discussed by Sachdev and Yee, 2007 (PMID 17237261). For a free-access review on targeting the IGF pathway see Ryan and Goss, 2008 (PMID 18245009).
Italian Research Findings About IGF Family in GIST
Italian researchers Braconi et al (PMID 18372285) assessed the expression of IGF-1 and IGF-2 in 94 KIT-expression-positive adult GIST samples using immunohistochemistry (cell staining methods). They scored IGF-1 and IGF-2 expression as negative, moderate, or strong. The results showed a relationship of strong IGF-1 expression to higher tumor risk category, larger tumor size, higher mitotic rate, and to the presence of metastases at diagnosis. Strong IGF-2 expression was related to higher risk category and higher mitotic rate. Follow-up data on the 77 patients without metastases at diagnosis showed relapse in 18 cases. Relapse was significantly more likely in patients whose tumors had higher expressions of either IGF-1 or IGF-2 or both. Among high-risk tumor patients, there was a trend for reduced recurrence rate in patients without expression of either IGF-1 or IGF-2. Interestingly, in this study 100% of GISTs expressed the receptor IGF-1R in the cell cytoplasm.
Braconi et al hypothesized that IGF-1R activation could trigger the MAPK pathway independently of KIT activation, and that GISTs could execute a self-sustaining autocrine loop of IGF activation causing GIST proliferation and preventing GIST cell death. (Autocrine means that a single cell both produces the signal and receives it: self-stimulation.) Of potential importance for patients with KIT exon 9 mutation, IGF-2 expression was strong in 70% of the exon-9 GISTs in this study. In contrast, in the less aggressive tumors with PDGFRA mutations, the majority (64%) were negative for IGF-2 expression. IGF-1 expression did not differ by mutation type.
MSKCC Research Results About IGFR-1 in Pediatric GISTs
Cristina Antonescu and a team from Memorial Sloan-Kettering Cancer Institute (Agaram et al, PMID 18483389) examined tissue from 17 pediatric GIST patients and compared genes expressed in the pediatric cases with the genes expressed in adult wild-type GIST and adult gastric GISTs. The MSKCC team found that IGF-1 expression was five times higher in pediatric GIST than in adult wild-type GIST based on microarray analysis of transcriptional profiles. The receptor IGF-1R was likewise overexpressed. [Other gene expression results in this study, as well as drug testing results on cell lines, are not summarized here because they are unrelated to IGF family topics.]
Fox Chase Findings on IGF in Wild-Type and Mutant GISTs
Andrew Godwin and his lab team investigated IGF signaling in wild-type GISTs (including both a GIST and a paraganglioma from one Carney Triad patient) compared to KIT-mutant GISTs (Tarn et al, 2008, PMID 18550829). In addition to the new published paper also see the presentation by Godwin at 2008 ASCO, abstract number 10507). Consistent with the Italian findings, the Fox Chase team identified IGF-1R expression in all GISTs, but especially in wild-type GISTs. The Fox Chase team detected gene copy number changes for the IGF-1R gene using microarrays and found that 70% of wild-type GISTs showed amplification of IGF-1R (2.5 to 4 copies), as did 27.7% of KIT-mutant GISTs. Clinically convenient cell staining techniques (immunohistochemistry) confirmed these results.
Next the investigators evaluated the effect of an anti-IGF-1R drug (NVP-AEW541) on two GIST cell lines that differed in sensitivity to imatinib (T1 cells with an exon 11 KIT mutation and greater sensitivity to imatinib, and 882 cells with an exon 13 KIT mutation and reduced sensitivity to imatinib). Both cell lines were equally sensitive to the IGF-1R inhibitor. Moreover, there was an additive effect of combining imatinib plus NVP-AEW541 on achieving cell death. Because using interfering RNA to silence IGFR-1 had less effect than NVP-AEW541, the researchers suspected that the drug also produces additional effects besides IGF-1R inhibition. Interestingly, consistent with the Italian hypothesis that IGF-1R activation could trigger the MAPK pathway independently of KIT activation, drugging IGF-1R did particularly reduce MAPK path activation.
The Fox Chase team concluded that drug treatment to inhibit IGF-1R needs to be investigated as a potentially useful strategy in GIST, both
- as a single agent in tumors that do not respond well to imatinib (such as adult wild-type tumors and pediatric GIST), and
- as a combined therapy to increase cell death in imatinib-responsive tumors.
Investigational Drugs Against the IGF Family
Several drugs targeting IGF family are in clinical trials at present or expected to enter trials, including the following:
- R1507 (see NCT00642941 trial for sarcomas)
- OSI906 (see NCT00514007 and NCT00514306)
Speculative Remarks
If further research were to confirm the Italian finding that exon-9-mutant GISTs showed especially strong expression of IGF-2, then targeting the IGF family in exon-9 GIST patients might help improve their response to Gleevec.
It is conceivable that in adult GISTs with KIT mutations, IGF-1 or IGF-2 expression might interfere with tumor cell response to imatinib by preventing apoptosis. Recently the epidermal growth factor receptor (EGFR) was found to prevent apoptosis in cancer cells which did NOT depend on EGFR signals for growth (Fidler et al, 2008, PMID 18455122.) If this were true, then combining an inhibitor of the IGF family with a KIT inhibitor (such as imatinib) might assist in killing more GIST cells and improving treatment response.
The normal occurrence of high IGF-1 levels during puberty and pregnancy certainly fits in with a potential link to pediatric GIST and Carney Triad tumors, which typically occur at these life stages. IGF signaling is to be a topic of discussion at the first NIH Pediatric GIST Clinic being held June 18-20, 2008, and we will be eager to hear the ideas from that meeting.
IGF-1 can activate hypoxia-indicible factor (HIF) pathways (Carroll and Ashcroft, PMID 16778202), which are relevant to pediatric GIST. In pancreatic cancer cells, HSP90 inhibition impaired IGF signaling as well as HIF pathways and reduced growth of tumors transplanted into mice (Lang et al, 2007, PMID 17975158). Therefore, it is possible that drugs to inhibit HSP90 and IGF pathways might work well together.
Trent et al (2006, PMID 16986125) found that when imatinib (Gleevec) is effective early in GIST treatment, the binding protein IGFBP-3 is upregulated; conversely, in imatinib-resistant GIST cells IGFBP-3 was down-regulated. The authors stated "The increase we found in IGFBP3 in imatinib-sensitive GIST cells and tumor tissue suggests that this protein may be an important early marker of FDG-PET imaging and the antitumor activity of imatinib." however, Trent et al did not offer any hypotheses about exactly how imatinib (Gleevec) could be affecting IGFBP-3.
Perhaps soon the relationships between different IGF family elements and GIST growth will be unravelled and will provide an effective treatment approach.
Additional Reading:
For free-access reviews about the insulin-related growth factor system in cancer, see these papers:
Tarn C, Rink L, Merkel E, Flieder D, Pathak H, Koumbi D, Testa JR, Eisenberg B, von Mehren M, Godwin AK
Insulin-like growth factor 1 receptor (IGF-1R) is a potential therapeutic target for gastrointestinal stromal tumors (GIST).
Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8387-92.
Ryan PD, Goss PE.
The emerging role of the insulin-like growth factor pathway as a therapeutic
target in cancer.
Oncologist. 2008 Jan;13(1):16-24.
Sachdev D, Yee D.
Disrupting insulin-like growth factor signaling as a potential cancer therapy.
Mol Cancer Ther. 2007 Jan;6(1):1-12.
Samani AA, Yakar S, LeRoith D, Brodt P.
The role of the IGF system in cancer growth and metastasis: overview and recent insights.
Endocr Rev. 2007 Feb;28(1):20-47.
Yu H, Rohan T.
Role of the insulin-like growth factor family in cancer development and progression.
J Natl Cancer Inst. 2000 Sep 20;92(18):1472-89. Review.
Last changed: Jan 30 2009 at 3:03 PMBack


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Just sharing the love, Gene!You can buy me a slice of your favorite NY pie the next time I'm in NYC! John K
Norma,As promised, attached are photos of my first try at baking longer, at a lower temperature - 25 minutes at 375 degrees, to be precise.As you can see, the pizza came out a bit undercooked, so next time, I'm going to try 400 degrees and if that still doesn't work, then 425, and maybe I'll cover the pie with a piece of foil until near the end if I see that the cheese is starting to burn.Also, I baked the pie directly on the middle rack in my home oven; maybe I'll try putting the pan on a pizza stone, next time.The pizza still tasted pretty good and the crumb was light and airy, but the bottom was not as crisp as I would have liked it to be. You'll also notice how, when I slid the pie out of the pan, the cheese on top slopped over the edge.On the positive side, the problem I was having, with cheese sticking to the side of the pan, pretty much vanished. For the first time, I was able to clean the pan out with a paper towel. So I'm guessing that the high temperature (500 degrees) that I had been using was "burning off" the oil (or in my case, butter-flavored Crisco) and "fusing" the cheese to the metal.So I'm hoping that I can find a combination of temperature and cooking time that will bake the pie within a reasonable amount of time, make the bottom crispy and not cause the problem of cheese sticking to the sides.Gene
Gene,Thanks for posting your results when baking longer at a lower temperature. Your pizza does look tasty!Norma
I was going to try 25 minutes at 425 next, but I think I'll try shuboyje's idea, on the post just ahead of yours: 25 minutes at 450, since he's so happy with his results.Gene
Gene,I, too, would be interested in seeing what a 65% Buddy's clone dough looks and feels like--especially since I don't recall ever seeing photos of Buddy's dough balls--and also what the finished pizza looks like in terms of crumb structure. To give you an idea as to what a 65% hydration Detroit style dough looks like, you might take a look starting at around 2:38 of the YouTube video at that was made to feature Jet's Pizza. From what I have been given to understand, the Jet's dough has a hydration of around 65%. You might also note at 3:05 that the dough balls do not look particularly highly hydrated and have surface irregularities that I do not think you would see with more highly hydrated doughs. Maybe Norma can comment on the Jet's video and the hydration issue based on her experience. Also, there is the question of "double kneading" and subjecting the dough to a lot of stretching and pulling, and what these terms really mean. Clearly, from photos that I have seen, several of the well known pizza operators who specialize in the Detroit style are using very highly hydrated dough to make their pizzas, including the Detroit Style Pizza Co, Via 313 and Klauzie's. It would have been nice to be able to show you a good cross section of the crumb of a Jet's square pizza but I could not find a photo outside of what was shown by PizzaHog in the Jet's thread.Peter
Howdy everybody! I just signed up to the site officially, but I've been glued to this thread for about the last week. I'm up to page 25 right now and I'll have it all wrapped up tomorrow.yesterday.
Jet's has a separate recipe for their round pizza dough and their square pizza dough. The one's pictured in the video are the round dough balls. This explains the hydration level looking around 65%
This was posted in the Detroit News in the early 80's:Buddy's Deep Dish Detroit Style Pizza CRUST:1 pkg yeast (dissolved in 1/4 c warm water)2 tsp dry milk (add to yeast & proof 10 min)1 tsp sugar4 1/4 c flour1 tsp salt2 Tbs olive oil1 1/4 c warm waterStir all ingr. plus yeast mxt. in large bowl using only half flour. When blended add remaining flour. Knead, cover, rise till double.Make 2 balls.SAUCE:2-15 oz cans tomato puree (Or one 29 oz can)2 Tbs olive oil1 tsp salt1/2 tsp garlic salt2 cloves garlic, minced1/2 tsp basil1 tsp oregano2 tsp sugarCombine all & simmer 15 minutes.Place dough in 2 heavily oiled 9 x 12 pans. Pepperoni on dough, then mushrooms then 4 cups of cheese. Scatter green pepper & onions on cheese. Then 3 long rows of sauce on top.Bake preheated 450 for 20-25 minutes.Please notice that this recipe uses less moisture % than what I am seeing here on page 20 of this thread.
You probably made the dough back when Mama Rosas was good, sadly they went downhill a few years back. Not that it's bad, just not what it was when I was first introduced to it.
Thanks again Pete!I'm using Pizza Hog's dough recipe from post 199. I mixed up the sauce according to the above referenced post and it's not very good at all. I'm going to add some water, perhaps crushed tomatoes and more sugar. I'm just getting into the Two Bills thread right now.A new Buddy's is opening later this year near Hall Rd. and Hayes (where Teddy's Times Square used to be) for the Michiganders out this way that would be interested.
Yes! That is an all around faaantastic looking pie....but the crumb; Momma Mia!!
Tonight's pizza. Now off to Showtime for the fight.


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Quilt Retreat
19 Comments
A.March 26, 2011 at 10:49 pm
What fun. You lucky goose!
KarenMarch 27, 2011 at 3:33 am
That hotel looks lovely! What is a Trunk Show?
JackieMarch 27, 2011 at 6:02 am
What a great place to retreat! I adore Sandy's work and can't wait to see her trunk show!!
Aunt SpicyMarch 27, 2011 at 6:08 am
~The Bargain BabeMarch 27, 2011 at 7:25 am
Looks like tons of fun! A trunk show sounds wonderful too. Can't wait to hear more about it.
AmandaMarch 27, 2011 at 8:17 am
Looks like so much fun! Can't wait to see more pictures. 🙂
Mary on Lake PulaskiMarch 27, 2011 at 9:02 am
You lucky girl Amy! I'll be watching for more on this retreat!
angelaMarch 27, 2011 at 9:51 am
Can't wait to see more pictures. So excited for you spending some time with Sandy!!!
BriawnaMarch 27, 2011 at 10:34 am
So jealous. We've finally finished graduate school and it was a perfect year for me to attend the quilt retreat (no nursing babies, pregnancy, a little income) and we move…to Arkansas! Someday, I will get back for that retreat. Glad it was fun.
upstateLisaMarch 27, 2011 at 12:01 pm
fun! looks like a great facility!
LeslieMarch 27, 2011 at 12:40 pm
oh lucky you…that looks like so much fun.
Live a Colorful LifeMarch 27, 2011 at 1:00 pm
Retreats ARE the best. I love it that you would rather be nearby Sandy Klop than a famous movie star!
LeilaMarch 27, 2011 at 2:24 pm
I Am jealous! I love her fabric too!
amylouwhoMarch 27, 2011 at 2:24 pm
supremely happy for you with a side of jealous. 🙂
The Tulip PatchMarch 27, 2011 at 7:42 pm
I'm sorry but I'm HATIN'! She is my fave fave. Seriously, I am glad you got to see her though because I know you are a fellow American Jane fan. I did get to touch her 2×2 quilt in Houston and meet her friend Kaye…CLOSE!
JudyMarch 28, 2011 at 10:56 am
What fun! Lucky you to have that experience!
alioopMarch 28, 2011 at 4:10 pm
It must have been the weekend for quilt retreats. I and four like minded sewing friends went to a lovely country town called Alexandra in Victoria.<br />There was much sewing, talking, laughing, eating, drinking, more sewing and lots of projects started and even completed.
KimMarch 28, 2011 at 5:18 pm
Sandy Klop is super nice! When I first started quilting she worked in my local quilt shop and used to help me pick fabric. That was before she was "American Jane". Now I look back and wish I had gotten to know her better!
KaraApril 1, 2011 at 3:34 pm
Wowser that sounds fun! And those quilts are simply stunning!


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Topic: upload an attachment and then send via a contact form
I have created a contact form which will email me once sent. Now I need to be able to have the option of attaching a document that will be emailed to me also. i dont need to save it in a db as it will be with the email and downloaded from there.
Im new to rails so would like to see what other people have done in this situation, ive done some reading and see that i will need the gem paperclip in most instances? Also i have looked at jquery/paperclip in github but this seems a lot of work for what i hope is a small piece of work? I could be wrong here mind, so apologies if i am
Any help greatly appreciated


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Greetings TeaFriends,
This NOTTI Round 2 features 2 truly incredible and rare Sencha selections.
For brief explanation of what NOTTI is (versus OTTI, NOTTI is NOT an OTTI), see here: http://www.teachat.com/viewtopic.php?f=74&t=17639
Sorry, no photos yet. The teas are sealed for freshness, but I will post photos after I open bags.


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Nature's Way, Ashwagandha, Standardized, 60 Vcaps
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Buffet Crampon 3613 Professional Oboe
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Includes: case and care products
Crafted In: French


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EDIT: finished in one morning
i turned it from this:
into this:
all the insides:
and when its all done:
i used my 11'' backup stock barrel thats on my vibe mainly because i didn't want to end up ruining my main one and it doesn't fit into the hole.
Now only one question remains, does it work? i dont have any air or paint to test this.
Edited by ThunderLights, 13 February 2011 - 02:20 PM.


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Home > Wisconsin > Langlade County > Lakes
Langlade County Wisconsin Fishing Lakes
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Lakes in Langlade County Wisconsin
Above is a map and a list of the lakes in Langlade County, Wisconsin. Many are open to public fishing. If you see a lake name that is duplicated, then try to narrow it down using the name of the USGS topographical map which is usually a prominent place or city nearby.