text:
Saunier Duval-Scott riders tackled the fast and flat team time trial of this year's Giro d'Italia opening stage aboard brand new Scott Plasma2 framesets that are claimed to be a full twenty percent more aerodynamic than before. Tubing profiles have been narrowed across the board to reduce frontal area but a number of specific features help clean up the airflow from front to rear as the bike makes its way to the finish line.
As compared to the old fork which was essentially just borrowed from the road lineup, the Plasma2 fork is now a proper aero bit that is not only well integrated into the rest of the chassis but also works with the newly dropped and cut-out down tube to yield a more continuous surface with the front wheel. The rear wheel is also well protected with a claimed eighty degrees of coverage from the deeply profiled seat tube but the new bottom bracket area is arguably the most visually striking area of the frame.
The new 'Speed Skeg' shell design is expectedly well reinforced but it also extends further down than typical and terminates in a small spoiler that supposedly helps direct air around the churning wheel. The connecting chain stays are then oriented perfectly horizontal behind the shell for roughly two-thirds of their length, which Scott claims provides better shielding from the turbulent air in that region.
Aero-enhancing details are also well thought out, such as the uniquely profiled water bottle bosses, fully internally routed cables that enter the frame behind the stem, and adjustable rear dropouts.
All of this additional surface area would normally be associated with additional weight but Scott has managed to make the aero improvements without adding any appreciable mass. Last year's CR1 tube-to-tube construction techniques have been traded for the more mass-efficient Integrated Molding Process on the new top tube, head tube, down tube, seat tube and front chain stay sections and the fiber content has been upgraded to Scott's top-end HMX blend. As a result, the claimed frame and fork weights of 1340g and 400g for a medium-sized sample are roughly inline with last year's Plasma.
Aerodynamic performance isn't the only area of improvement, either. The bigger top tube and down tube should increase torsional rigidity of the front triangle for better power transfer and handling precision, the new seat stay design is supposedly more comfortable, and a new Ritchey head on the integrated seat mast includes far more fore-aft adjustment before to provide effective seat tube angles ranging from 73-78 degrees. A new extra-small (47cm) size will also be added (built around 700c wheels, no less) to cater to the vertically-challenged crowd.
For full results, report and photos from the Giro d'Italia, visit Cyclingnews.com.


text: Wii Firmware Upgraded to 4.1Luke Plunkett7/16/09 12:30amFiled to: NintendoWiiWiiConnect24Wii sports resortNews94EditPromoteShare to KinjaToggle Conversation toolsGo to permalinkIf you've got WiiConnect24 hooked up on your console, it should be glowing blue right about...now, with Nintendo having just pushed through firmware update 4.1AdvertisementUnless you're adverse to this type of business (ie you're the homebrewing type), you might want to grab it, especially if you're planning on getting Wii Sports Resort, because when 4.1 was released in Japan earlier this month, that's what it was for. To fix a bug in Wii Sports Resort. Can't imagine it being much/any different for Western Wiis.[Image]Reply94 repliesLeave a reply

subset: commoncrawl


text:
New to Poly
View Single Post
Senior Member
Join Date: Feb 2011
Posts: 906
Originally Posted by
1) How did any of you come into the polyamorous lifestyle?
2) Why do you enjoy being in a polyamorous relationship?
3) How do you deal with the ugliness that jealous and envy can bring?
Yay! A poll! I love polls!
1) I can't remember when exactly I first heard the word 'polyamory', but when I found Deborah Anapol's book in the library I immediately recognized the word. It just had an 'ah, this makes sense to me' effect on me. I had truly enjoyed watching documentaries on the subject, and being such a small country, those documentaries are what started the journey of self-discovery for many people from what I've heard!
2) More happiness for everyone! Also, a very rapid programme of self-growth complete with new relationship skills is in store. Lots of processing, which can start off good things in other parts of your life, too. I feel I have so much love to give that no one person could handle all of it. Also, the people I am with are just too good not to share! And you get to meet people and have experiences you wouldn't otherwise.
3) For me, the hardest part is seeing or hearing someone else feel neglected, which can be the starting point for jealousy. Especially if I can't just cuddle the insecurities away, which isn't possible anyway but it would certainly make me feel better.
Me: bi female in my twenties
Dating: Moonlightrunner
Metamour: Windflower
View Public Profile
Find all posts by BlackUnicorn


text:
Click here to watch this clip.
This is a great example of a successful auction with an unusual ending. The auctioneer, Violet Sanford, needs to raise $250 quickly to keep her job. When the bidding reaches $250 she ends the auction, oblivious to the fact that the bidders would have gone higher (incurring a significant opportunity cost in the process). This scene can be used to introduce or discuss auctioning mechanisms.
Available on iTunes Available on Amazon.com- Your Thoughts
- Was this helpful to you? (0 votes)
- Tags
- Related Content
What People are saying...
Students, got an econ question?
- Who's Dirk?
- More on the man, himself. Meet Dirk
- Econ Media Library
- Check out multimedia tools, videos and more in our Media Library


text: The Division of Pediatric Transplant Hepatology and the Department of Surgery at Columbia University, College of Physicians & Surgeons, Columbia University Irving Medical Center (CUMC) is seeking a Pediatric Transplant Hepatologist to join an active and growing academic practice. This is a full-time faculty position at the academic rank of Assistant or Associate Professor of Pediatrics @ CUMC and Attending Physician at NewYork-Presbyterian, Morgan Stanley Children's Hospital (NYP-MSCH). MSCH is ranked the #1 Children's Hospital in New York State and is nationally ranked in 10 pediatric subspecialties, according to U.S. News & World Report (2016). The Pediatric Center for Liver Disease & Transplantation at CUMC and NYP-MSCH is a well-established transplant program with 4 certified pediatric transplant hepatologists, 3 pediatric liver transplant surgeons, 4 physician extenders, 2 social workers, a Transplant PharmD, a medical assistant, a dedicated nutritionist, a pediatric transplant hepatology fellow, 2 pediatric transplant surgery fellows and a full research core group. Our team provides complex hepatology, liver and small bowel transplant services for pediatric patients with a wide range of conditions. There is close collaboration between adult and pediatric hepatologists, surgeons, radiologists, expert hepatobiliary pathologists, patient support staff and additional consultants affiliated with the program. The successful applicant will also have clinical expertise in both inpatient and outpatient liver (small bowel transplantation – a plus), as clinical responsibilities will include care and management of such patients within the Division and NYP-MSCH. Board eligible/board certified in Pediatric Transplant Hepatology preferred. Additional clinical responsibilities will include standard conference preparation for patient management and transplant selection conferences, inpatient and outpatient consult services; participation in the education of medical students, residents and fellows at CUMC/NYP-MSCH and scholarly activity; all requirements of the academic tracks and promotions within the Department of Pediatrics. Such scholarly activity may include participation in collaborative research; publication of original articles; presentations at local, regional and national meetings, CME events; and the development of teaching methods or clinical curricula. Involvement in clinical research trials is also expected. In addition to responsibilities in clinical care and scholarly activities, the successful applicant will be expected to participate in the academic activities of the division, the department, including research seminars and teaching conferences. University and public service activities are also expected of faculty. For interested candidates or for more information, please email a cover letter and CV to Dr. Steven J. Lobritto at firstname.lastname@example.com. |


text:
Loose Joints
Is It All Over My Face? (Kon Edit) Vinyl 12"
West End
↳ essential edit + unreleased versions of the dancefloor classic
Heat alert! Kon coming through with a crucial edit of the timeless West End classic "Is It All Over My Face?". Sourcing the original stems, digger/producer extraordinaire Kon (King Of Nothing) totally recreates the track using BOTH the female and male vocals for a completely new "Duet" version. To top it off, he's given the track a fresh mixdown that breathes new life into the Arthur Russell-produced classic. The result is sure fire floor worker that will bring out dancers young and old. Worth it for this one alone, but West End has gone all out and hooks up a previously unreleased Female Vocal 7" version AND a 13 minute unreleased version of the original too. Essential material for the disco crate. Recommended.
- music label: West End Records 2015


text:
Investing Crash Course in Currency Trading, An Trading and Investing in the Forex and Futures Markets
English | Audio: aac, 44100 Hz, stereo | Video: h264, yuv420p, 960x540, 25.00 fps(r) | 144MB
Genre: E-learning
If you are going to trade currencies, you had better shorten the learning curve! Experienced broker and trading educational author Carley Garner guides viewers through seven clear and concise lessons exploring the world of FOREX. This simplified guide to the basics of FX is a must for anybody looking to get involved in currency trading. Garner efficiently steers beginning FOREX traders through easy-to-follow discussions of currency market mechanics, margin calculations, pip value calculation, the truth about leverage, understanding pairs trading, reading and interpreting currency quotes, and navigating a trading platform. She also provides insight on the various FX brokerage types and the realities of speculating in the FOREX market.
Buy Premium Account and download as fast as you can or you will lose file you need ( File death because of Copyright Infringement )
Download ( Secureupload)
Download ( Uploaded )
Download ( Lumfile )
Download ( DizzCloud )
Click my nick to see more my articles
Site BBcode/HTML Code:


text:
Wenatchee | Arts | Visual Arts Wenatchee's November Arts & Art Walk start Nov 7th 5p by karen dawn dean Nov. 5, 2014, 6:32 a.m. Each 1st Friday you have the opportunity to enjoy our valley's art and talk with the artists. Of course each venue and every artist wants you to come see their work. However these groups who participate with listings in the November Arts Brochure also want you to look beyond their walls…because they know that art grows and lives in nooks and crannies. So, when you go out art walk night, take in as much as you're able...you'll be making an investment in growing depth and diversity in our local arts ...
Wenatchee | Arts | Visual Arts Wenatchee's October Art by karen dawn dean Sept. 26, 2014, 7:34 a.m. From performance art in a parking lot to art in the galleries; a pop-up museum to the art of wine bottle labels; artists' studios open house to artists demonstrating the craft of their art....October has some interesting art experiences. Get up and get out to enjoy our creative vibe!
Wenatchee | Arts | Visual Arts August Art in Wenatchee starts with the Art Walk, Aug 1 by karen dawn dean July 31, 2014, 10:22 a.m. August Art in Wenatchee kicks off with the art walk, Friday Aug.1st beginning 5p. If you're a person who likes to meet the makers, then the art walk's for you! …if you like your art experiences solo, you've a month of aesthetic possibilities in the offing.
Arts | Visual Arts July is a great time to enjoy Wenatchee's Art! by karen dawn dean July 3, 2014, 8:47 a.m. Take a walk-bike-or-drive to see Wenatchee's July art exhibitions!
Wenatchee | Arts | Visual Arts In June, take a Walk/Bike/Drive to enjoy Wenatchee's Arts by karen dawn dean June 4, 2014, 9:20 a.m. First Friday evening, come out to meet some of Wenatchee's Visual Artists. Streets and sidewalks are open.
Arts | Visual Arts Wenatchee's April Art starts with the First Fridays Arts Walk/Drive, April 4th by karen dawn dean April 2, 2014, 2:19 p.m. The idea is a simple one. By joining many individual venues into an organized art walk, the collective effort magnifies our community's interest and cultural awareness in the month long art exhibitions. The goal is to move people around town into different venues that offer different art experiences.
Arts | Visual Arts Wenatchee's March Art, experience its diversity! by karen dawn dean March 3, 2014, 9:01 a.m. Friday night, take an art walk. Pick up the March Art flyer and plot your own self-guided tour into the participating shops, showrooms, galleries, campus theater and museum.
Arts | Visual Arts Scott Bailey: "Instant Landscape" in the WVC MAC Gallery, Feb 7 - 28 by karen dawn dean Feb. 6, 2014, 8:07 a.m. ...where artists are encouraged to challenge themselves and traditional notions about how a gallery can be used.
Arts | Visual Arts Wenatchee's Arts Walk turns three! by karen dawn dean Feb. 4, 2014, 3:43 p.m. As we begin this fourth season, the February 7th art walk has installations that offer the opportunity to go beyond looking at art and enter the world of seeing and feeling it.
Arts | Visual Arts Whether you walk or drive, head out January 3rd and enjoy a night of Wenatchee's Arts….go LIVE! by karen dawn dean Jan. 2, 2014, 9 a.m. Pick up information and the walking map at these participating venues, MAC Gallery, Robert Graves Gallery-both on WVC Campus; Wenatchee Valley Museum, Wenatchee Chamber Showroom, Caffe Mela.
Music | Arts | Visual Arts Ring in the holidays and Wenatchee First Fridays Arts Walk, Friday Dec. 6th 5 - 7 PM by karen dawn dean Dec. 5, 2013, 10:45 a.m. Ring in the holiday season and your community's arts when you take a self-guided Arts Walk/Drive this Friday night. From brass handbells to our 5th graders small bronze sculptures, it will be a great night to unplug, get-up, get-out and Go-LIVE!
Music | Wenatchee | Arts | Visual Arts Nov 1st, whether you walk or drive, enjoy a night exploring Wenatchee's Arts! by karen dawn dean Oct. 27, 2013, 10:41 p.m. Take a self-guided Wenatchee First Fridays Arts Walk tour. There are eight stops along the way. From any of these, pick up the map and plot your next stop. Here's a bit about who's showing what, where....
Arts | Visual Arts Wenatchee First Fridays...take a Walk for Wenatchee's Arts October 4th by karen dawn dean Sept. 26, 2013, 9:30 a.m. During Wenatchee First Fridays ArtsWalk, take a self-guided tour of Wenatchee's Arts scene.
Music | Wenatchee | Visual Arts September 6th, go LIVE to enjoy Wenatchee's ArtsWalk by karen dawn dean Aug. 29, 2013, 11:23 a.m. What kinds of arts move you? Are you drawn to the tried-and-true, traditional modes of expression; or more experimental and contemporary artforms? This month there's a some of almost everything....
Arts Take a Walk for Wenatchee's Arts by karen dawn dean July 29, 2013, 10:46 p.m. The August 2nd self-guided Wenatchee First Fridays ArtsWalk is again grouped in Wenatchee's Historic District. There are 10 venues open between 5 -8 PM…come meet the artists. Here's a bit about the artists, their month long installations and why it's worth getting out and walking for the arts.
Arts July 5th WENATCHEE FIRST FRIDAYS Self-Guided ArtsWalk-Bike-Drive by karen dawn dean July 3, 2013, 11:09 a.m. Take a Walk-Bike-or-Drive....for the ART of iT! There are 10 stops along this month's exploration of Wenatchee's Arts.
Arts On July 5th,Take a Walk-Bike-or-Drive...for Wenatchee's Arts! by karen dawn dean June 23, 2013, 1:32 p.m. This month, July 5th Wenatchee First Fridays ArtsWalk has 10 venues. Here's a photo blog about who's exhibiting what...where!
On June 7th, take a walk-bike-or drive...for the art of it! by karen dawn dean May 23, 2013, 7:46 a.m. The June 7th Wenatchee First Fridays ArtsWalk has expanded to 12 venues. Here's a photo blog about who's exhibiting what...where!
June Wenatchee First Fridays ArtsWalk Set by karen dawn dean May 21, 2013, 4:13 p.m. Five new venues join the June Wenatchee First Fridays ArtsWalk-Bike-Drive.
May 3rd, Take a Walk-Bike-or-Drive for Wenatchee's Arts by karen dawn dean April 24, 2013, 6:57 p.m. On this month's self-guided tour of Wenatchee's arts, enjoy an experimental art installation, the works of three photographers, a painter's ode to nature, 94 years of Apple Blossom Festival memorabilia, a town full of bronze sculptures, and an orchard themed art exhibit. As usual, the art experiences offered are diverse…and spread out; so you might want to grab your bike to see it all. Have fun, ride safely and enjoy!


text:
Moving week is finally here. By this time next week, we'll be ensconced in our new home, taking stuff out of the boxes we're filling now. The picture above is one load of donations to a friend's library sale. A lot of these books came from library sales to begin with, and more than a few of them are returning to the sale from whence they came.
Though our apartment is a good size, there's no way to bring all of the books. For me, moving the books is what makes the move real. Books are the first thing down and first thing up (second, if one counts bookcases) if I have any say in the matter, and the process of deciding what to bring and what to release into the wild is an adventure all on its own. Some decisions are easy. Research books purchased for a project that is now long completed, interests that have changed, or duplicate copies are like that. Others are trickier. Have I read that? Am I going to read it? Really? If read, will I reread it? Can I get rid of the paper version and replace it with electronic?
I've fished more than one rescued book out of the DH's discard pile because he does not understand the neccessity of an obscure title, but I leave his picks of his own stuff alone. There are books I can't part with, because they have fused with me and it would be like excising a body part and sending it off into the unknown. Others have had their time with me and I like imagining someone else idly browsing the romance section of the sale and finding an unexpected treasure. They don't know it yet, but they have just touched their favorite book for the first time. Kind of exciting there.
Other books will go into the storage unit, either for a short time or until we make our next and hopefully final move. The rest, though, the special ones, those we count worth the trouble of packing and hauling down the stairs, onto the van, out of the van, up the stairs and into their eventual homes on whatever bookcases will fit.
When I last moved out of a college dorm room, many, many years ago, I divided my books into books I would be devastated if I lost and books whose absence I could bear. It hasn't become any easier to move, but the criteria is still the same. Thankfully, for those that are staying with me, it's only a short parting. I'll see them again in the new place.
How do you decide what books make the move with you?


text:
Why Kids Need Recess
More and more, parents are protesting school policies that allow teachers and administrators to withhold recess to punish student misbehavior. Common infractions include tardiness, acting out in class and failure to complete homework—everyday childhood behaviors that result in numerous children having to go without recess on any given day.
The research is clear. Children need recess. It benefits every aspect of childhood development—physical development, of course, but also social, emotional and intellectual development as well. Following are seven reasons why, if we want our children to succeed, recess should not be denied.
Recess increases focus. Dr. Olga Jarrett, with her colleagues at Georgia State University's Department of Early Childhood Education, approached an urban school district that had a no-recess policy. They received permission for two fourth-grade classes to have recess once a week so they could observe the children's behavior on recess and non-recess days. Their results showed that the 43 children became more on-task and less fidgety on days when they had recess. Sixty percent of the children, including five with attention deficit disorder, worked more and/or fidgeted less on recess days.
Natural light improves wellness. Sunlight stimulates the pineal gland, which is the part of the brain that helps regulate our biological clock. It is vital to the immune system, and simply makes us feel better. Outside light also triggers the synthesis of vitamin D, which a number of studies have demonstrated increases academic learning and productivity.
Recess reduces stress. The National Association for the Education of Young Children recommends unstructured physical play as a developmentally appropriate means of reducing stress—a valuable benefit given that stress has a negative impact on learning and health. For many children, especially those considered "hyperactive," recess is an opportunity to expend energy in a healthy, suitable manner. Outside, children can engage in behavior—loud, messy and boisterous—considered unacceptable indoors. And because recess is a break from structure and expectations, children have an opportunity to take control of their world, which is a rarity in their lives.
Recess develops social skills. Recess may be the only time during the day when children have an opportunity to experience socialization and real communication. Children don't engage in the neighborhood play of earlier generations, so once the school day ends, there may be little chance for unstructured, natural social development. After all, in class children generally are not encouraged to socialize, but rather are expected to conform and remain quiet. Some school policies even go so far as to prevent children from talking to one another during lunch. How can children with so few opportunities to socialize and communicate be expected to live and work together in harmony as adults? When and where will they learn how?
Exercise is healthy. Many children suffer from obesity, but even children at healthy weight levels benefit from physical activity, and in fact require it for optimal health. The outdoors is the best place for children to burn calories, practice emerging physical skills and experience the pure joy of movement. Research has even shown that children who are physically active in school are more likely to be physically active at home, and children who don't have the opportunity to be active during the school day don't usually compensate during after-school hours.
Physical activity feeds the brain. Thanks to advances in brain research, we now know that most of the brain is activated during physical activity—much more so than while sedentary. Movement increases the capacity (and possibly even the number) of blood vessels in the brain. This expedites the delivery of oxygen, water and glucose ("brain food"), thereby optimizing the brain's performance. Furthermore, numerous studies have shown that students who are physically active improve their academic performance, achieve higher test scores and demonstrate a better attitude toward school.
There is one more reason recess should not be withheld from children as punishment: It doesn't work. Experimental studies and anecdotal evidence point out that in any given school, it's generally the same children who tend to have their recess withheld, indicating that the threat is ineffective. And, as Eric Jensen, author of several books on brain-based learning, tells us, remaining seated for periods longer than 10 minutes "reduces our awareness of physical and emotional sensations and increases fatigue," resulting in reduced concentration and discipline problems. Demanding that children move less and sit more is counterproductive. Research, and our own common sense, tells us we should be doing the opposite.
About the Author:
Rae Pica is a children's physical activity specialist and the author of 18 books for teachers and parents. Her blog, The Pica Perspective, is at raepica.com. You can hear her interviews with experts in the fields of education, child development and the neurosciences at bamradionetwork.com.
This article appeared in Pathways to Family Wellness magazine, Issue #25.
View Article References
View Author Bio
To purchase this issue, Order Here.


text:
COLUMBUS - Ohioans may have expressed outrage over the last few months over Statehouse political scandals, but they resoundingly decided that what was on the ballot yesterday wasn't the answer.
Voters rejected outright proposed constitutional amendments that would have overhauled redistricting, election supervision, campaign contribution limits, and absentee voting.
The changes' mostly Democratic supporters claimed a win in sending a message to majority Republicans that political reform has to be on their agenda.
The mostly Republican opposition countered that would-be reformers pursued an "inside baseball" agenda instead of issues like the economy that matter most to Ohioans.
"Voters are the one who sent the message, and what the voters said is they will not have their constitution hijacked by a bunch of out-of-state special interests," House Speaker Jon Husted (R., Kettering) said.
The controversial centerpieces, amendments stripping state elected officials of their ability to redraw congressional and legislative districts and oversee Ohio elections, both failed overwhelmingly with 71 percent of voters rejecting them with 71 percent of the vote counted.
Proposed amendments that would have mostly reduced campaign-contribution limits and opened wide absentee ballot voting failed with 64 percent and 68 percent, respectively.
Reform Ohio Now, the mostly Democrat-leaning coalition supporting the amendments, took credit for the General Assembly's rush to enact its own version of no-fault absentee voting in a bid to derail the ballot version.
"Even though it wasn't Coingate that began our efforts here, that issue is not going to go away," said Herb Asher, political-science professor at Ohio State University, one of the reform effort's leaders.
"We're going to have more indictments, and next year, an election year, I would hope that we'll have candidates competing with each other, saying 'I'm going to clean up Ohio' and the other saying, 'No, I'm going to clean up Ohio even more.'●"
Coingate is the statewide scandal that has dominated GOP politics since The Blade began reporting in April about problems with a $50 million investment the Ohio Bureau of Workers' Compensation made in two rare-coin funds managed by Tom Noe, a Republican fund-raiser. Mr. Noe was indicted last month on three felony counts for laundering money to the Bush-Cheney campaign.
Mr. Husted said redistricting reform remains on the table for majority Republicans. "One of the things we have to be mindful of is Ohioans did say no today," he said. "We have to make sure that we have something that they would say yes to."
Issue 4, billed as a means of preventing the majority party from manipulating district boundaries to partisan and incumbent advantage after each U.S. Census, would have given the role to an appointed panel.The creation of competitive districts would have been the primary goal.
"The Republican insiders didn't want the system changed because they benefit from it right now," Mr. Asher said. "The Democratic insiders didn't want it changed because they hope they'll benefit from it next time."
Contact Jim Provance at:
or 614-221-0496.


text:
I was browsing recipes one day when I came across one for Cilantro Lime Chickpea Salad by Mind Over Batter. It looked phenomenal and I will definitely be making her version of this very shortly. But I didn't have any fresh limes or cilantro in the house but wanted to try my little spin on it. So I roasted the chick peas first, like I did when I made the Roasted Chickpea & Leek Hummus, then I just added some scallions for color and used some more of that wonderful Pomegranate Balsamic Vinegar from Pampered Chef I purchased. This was SO easy to make, healthy and filling. I just wish I had made more! This would make a great salad on it's own or used on top of tossed salads to give it a little something extra.
Roasted Chick Peas in Pomegranate Balsamic Vinaigrette
(Inspired by Mind Over Batter Cilantro Lime Chickpea Salad)
1-15oz. Can Chick Peas, rinsed and drained
1 Scallion (approx. 2 tbsp.), chopped
2 tsp. Fresh Rosemary, chopped
3 tbsp. Pampered Chef Pomegranate Balsamic Vinegar
3 tbsp. Extra Virgin Olive Oil
Place chickpeas on a baking sheet, spray with cooking spray and roast in 425 degree oven for 15 minutes. Let cool. In a bowl, mix together the chickpeas, scallions, rosemary, vinegar and oil until well blended. Makes approx. four 1/2 cup servings.
Points+=7pts per 1/2 cup
Friday, January 20, 2012
4 comments:
Subscribe to:
Post Comments (Atom)


text:
Techs clear air ducts and dryer vents of dirt and debris to improve airways and lower energy costs
HVAC specialist cleans and inspects heating, ventilation, and air-conditioning systems during a home visit.
... fan motor, test limit switches, and check the thermostat, gas burners, amperage, gas valves, blower control, heat strips, filter, anticipator, defrost board, electrical connections, and safety controls.
HEPA vacuum system removes all dust, dirt, and debris from air ducts, resulting in spotless vents passing clean air
From the merchant: Air duct unlimited supply line cleaning. Furnace & AC inspection. Mold Inspection. Furnace Blower motor inspection.
From the merchant: Higher quality HVAC,dryer vent, furnace,A/C cleaning,UV lamp installation.
Licensed technicians clear air vents of dirt and debris for healthier air circulation
Techs perform safety inspection and clean furnace sensors and burners; water heater flushing keep systems operating efficiently
Air-vent technicians clean air vents and grills, removing dust, pollen, and animal dander
From the merchant: $39 for HVAC Cleaning for unlimited Vents and Inspection of Furnace, A/C, and Dryer Vent ($245 Value).
Cleaning specialists will perform a complete inspection and cleaning for a residential heating and cooling system
From the merchant: A/C Tune-up. Comprehensive air conditioner inspection.
From the merchant: OUR ultimate goal is customer satisfaction while providing excellent options for your cleaning needs.
Once the thermostat senses that the air temperature has dropped below a set number (say, 72 degrees Fahrenheit), it sends an electrical signal to the burner.
From the merchant: Service experts clean and inspect all components of HVAC systems to provide optimal home heating and cooling conditions.
From the merchant: Ill provide the highest quality of work possible,because Im owner/technition. I want youll be happy/recomended me.
we offer ducts and vents cleaning dryer vent cleaning , furnace and attic inspection .
A Chat with Front Range HVAC.
From the merchant: We are a family owned.We want you to have the best experience with home service company you have ever had.
From the merchant: Echo One LLC is a local family owned HVAC contractor, dedicated to quality service and lifetime relationships.
Local and family-run company offers its clients services within heating and cooling industry
From the merchant: Comprehensive furnace inspection with minor cleaning.
Professionals clear dust and allergens out of HVAC and dryer vents, dramatically reducing the risk of fire and improving indoor air quality.
From the merchant: Family run Heating & Air Conditioning business with over 25 years experience in the industry.
Professional HVAC technicians keep home temperatures comfortable with thorough air conditioner and furnace tune-ups.
From the merchant: Professional residential and commercial air duct and dryer vent cleaning with best results guaranteed!
HVAC professionals ensure good air quality and system efficiency with an A/C tune-up or reduce temperature with an evaporative cooler.
Licensed techs inspect and tune-up air-conditioning systems, ensuring homes are ready for summer's heat with frosty, efficient operation
Insured professionals tune-up your HVAC system, ensuring that it is in good operating order.
Heating and cooling system pros get homes winter-ready with a thorough furnace performance and safety check
Discover new restaurants, spas, things to do & more great deals added daily!
*Valid on 1 unit per transaction; max 1 Local or Getaways deal per customer. Max discount $30. New customers only. Exclusive and non-transferable. Ends 3/31/17. Full details: gr.pn/promofaq


text:
Written by:Zoe on: November 5, 2014Jollof – 'Benachin' one pot rice
Jollof is by far and away West Africa's most readily eaten and available food and also known as 'party rice' because of its frequent centre stage placing at dinner party tables and banquets.
There are many arguments between Nigerians and Ghanaians about who makes the best Jollof and variations exist in Sierra Leone, Togo, Liberia, and it goes on! In Cameroon they use coconut milk and in Gambia they bake it and it's thought to come from the Senegalese dish 'Benachin' – one pot rice in the Wolof language.
Almost everyone familiar with Jollof has a different recipe for it: nobody's Jollof is as good as their mother's or grandma's, but the principle is always rice cooked in a spiced blend of tomatoes and onion which gives it its rich red colouring – you can use whatever meat and vegetables that take your fancy.
What epitomizes Ghanaian jollof for me is the sweet heat from Scotch Bonnet chilli and the inclusion of ground crayfish (available from African groceries) – a very distinctive smoky fish flavour and just enough robust heat from the chilli to warm the palate without having to reach for a glass of milk.
This is my recipe for Jollof with chicken.
Ingredients: recipe serves 6
6-8 pieces of bone in chicken (thigh or drumsticks)
2 large onions, finely chopped
2 gloves garlic, minced
1 Tbsp fresh or dried thyme
1 large bay leaf
5-6 guinea peppers, crushed
1 scotch bonnet deseeded and diced
½ tsp freshly grated nutmeg
1 tsp cinnamon
2 Tbsp (40g) Crayfish or Ground Prawn powder
1 tsp salt
4 Tbsp peanut oil or sunflower oil
1 tsp hot chili powder
1 tsp curry powder
300g long grain white rice
Chopped parsley or coriander to garnish
Shito hot pepper sauce, to serve
For the tomato sauce:
1 large onion, roughly chopped
6-8 large tomatoes chopped
200 grams tomato puree
1 scotch bonnet deseeded and diced
1 tsp salt
Stage 1: Make the broth
Heat a heavy based pot on a low heat and add the chicken along with:
1/2 the chopped onion
the minced garlic
bay leaf
guinea peppers
scotch bonnet
nutmeg and cinnamon
crayfish powder
Stir well
Add enough water to just cover the chicken and bring to the boil then simmer for 20 mins
Once the chicken is tender, remove from the pot and place on a baking tray and cover with foil to keep warm until you're ready to put it in the oven.
Drain the fragrant broth into a jug and keep to one side to add to your rice later.
Stage 2: to make the tomato sauce
In a blender combine
The chopped tomato
Tomato puree
Roughly chopped onion
One scotch bonnet (deseeded)
A teaspoon of salt
Blend well into a smooth sauce
Stage 3: Making the jollof
In the same pot you used to make the broth heat the oil over a medium heat and fry the remaining onion until soft.
Add the chili powder and curry power – stir in to coat the onion and continue to sauté for 5 mins
Add some of the tomato sauce, saving aside one ladle or so to add later once the rice is in.
Add the broth to the pan and stir in.
Wash the rice thoroughly (I usually wash it three times) to remove as much starch as possible, then stir it in to the broth so that it's evenly coated.
Reduce the heat and cover pan with tin foil to keep in the steam, then replace the lid.
Simmer for 30 minutes until all the liquid has been absorbed and the rice is tender.
Finally, stir in the reserved tomato sauce and take off the heat.
Preheat the oven to 180C.
With 15 minutes to go before the rice is done, remove the foil from the chicken and place into the hot oven for 15 minutes.
Serve the rice with the chicken pieces on top and sprinkle the fresh herb garnish over the top. Serve with hot pepper sauce on the side.
If the sauce isn't hot enough before adding the rice, the rice will soak up the cold water and become soggy.
If you find that half way through cooking the rice is too dry, top up with additional water adding a cup at a time as necessary.
You can make this an even meatier dish by adding extra meat such as lamb, beef or goat but you can also make it a delicious vegetarian dish also using fresh garden eggs, carrots and peas plus other mixed vegetables, and excluding ground crayfish.


text:
Elementary School Kids
Featured Posts
I'm starting our Christmas shopping soon, so I'm trying to figure out some books. What books would you all recommend for a 6 year old girl? She's not to interested in reading so I'm hoping that with Santa bringing her books might help.
Thanks! =)
My boys LOVED the Wimpy Kids books too. The girl ones look JUST like the boys, but they are pink and purple. They usually are right next to them on the shelf at Barnes and Noble too.
Quoting mommy-of2cuties:
Quoting mjande4:
Magic Treehouse, Diary of a Wimpy Kid's female counterpart (sorry don't know the name, just know what the books look like), Pinkalicious.
Thanks! I didn't know they did a female counterpart for Diary of a wimpy kid! lol! My son loves those books lol!
My kids and I LOVE Pete the Cat books! They are so funny! Especially the one about his new shoes! We quote the book a lot during play and my daughter took it in for show and tell she loves it so much. We just got a flyer for the Book Fair next week and my kids were excited because there is a new Pete the Cat book in it.


text:
Mark Cavendish sprinted to victory in the 13th and longest stage of the Giro d'Italia, and favorite Vincenzo Nibali retained the overall lead to boost his chances of a first victory in his home country's Grand Tour.
Cavendish won in a time of 6 hours, 9 minutes, 55 seconds to claim a second straight stage victory and a fourth in this year's Giro.
Giacomo Nizzolo was second, with Luka Mezgec third in a bunch sprint
at the end of the 254-kilometer (158-mile) leg from Busseto to
Nibali maintained his 41 second lead over Cadel Evans. The mountain stages are coming up soon in the race.
Tour de France winner Bradley Wiggins and defending champion Ryder Hesjedal withdrew from the race before the stage began.
- More about:
- Cycling
- Mountains
- Tour De France
- Wilderness


text:
Outdoor Research SG Water Bottle Parka, 1 Liter
Padded Insulated Bottle Case
Perfect place for your LaRue Nalgene Bottle. This great case will help keep the
contents of your bottle cold (or hot) for hours. A hefty YKK Zipper keep the
contents secure. The generous padding also protects the bottle from dings and
cracks. Velcro straps secure the case in place on your belt or backpack.
Foam insulated on sides, top and bottom
Zipper top closure construction
Qik-Stik® attachment system attaches easily and quickly to pack
Designed with MOLLE compliant straps to weave through webbing of the pack, the
individual Load Bearing Equimpent (ILBE) and the Load Bearing Vest (LBV) system
Cordura® A high-performance fabric resistant to abrasions, tears and scuffs.
Colors: Tan
Does Not Include The Bottle


text:
Hi All,
Please tell me the date of exam for 208 -PIL(Public Interest Lawyering)
Could u please provide me the date sheet for LLB Second Year to be conducted by CCS University Meerut... need urgent.
Mihir tatran
06-08-2008 Wednesday Contract II (Specific Contracts) K 201
09-08-2008 Saturday Family Law I (Hindu Law), Arbitration, Conciliation and Alternate Dispute Resolution System K 202
13-08-2008 Wednesday Family Law II (Mohammdan Law), Family Law II (Mohammedan Law) K 203
19-08-2008 Tuesday Administrative Law K 204
22-08-2008 Friday Company Law K 205
27-08-2008 Wednesday Labour Law & Industrial Relations, Labour Law & Industrial Relations K 206
30-08-2008 Saturday Property Law & Easement, Property Law (Transfer of Property act & Easement Act) K 207
03-09-2008 Wednesday Optional [Conflict of Laws / Banking Law (Including Negotiable Instruments Act) / Investment & Security Laws / Trusts, Equity & Fiduciary Relationship Criminology and Penology K 209, K 210, K 211, K 212, K 213
For practile paper - contact your college.
Regards: - [url]www.taxmanagementindia.com[/url]
hi neha,
the date sheet has been declared i.E, 6.08.(201), 13.08(202),19/8(203),22(204),27/(205)30/(206)03.09(213).
regards mohit
Please advise the timing of exam for 2nd year LLB exam
> Rajeevkumar wrote:
> Please advise the timing of exam for 2nd year LLB exam
The timing is 2 to 5 PM
LLB Second year Exam Time will be 2 to 5 PM
[url]http://ccsuniversity.info/[/url] Go to link and find datesheet.
hi plz tel me result of ll.b.2year.whn result declare.
can any body send me the complete syllabus and question papers of LLB 3 year of CCS university thanks Maanas (email@example.com)
I would like to know the admission procedure for LLB correspondence
please send me ccs llb second year datesheet to [email]email@example.com[/email] please please its urgent
please send me ccs llb second year datesheet to [email]email@example.com[/email] please please its urgent
Recent Posts in
Education in India
Most Popular Posts at Sukh Dukh


text:
Welcome to the home page of Dun Ringhyll
Dun Ringhyll is a three bedroom luxury self-catering accommodation set in the picturesque market town of Sedbergh in the Yorkshire Dales National Park. The house is in a quiet cul-de-sac with off road parking for one car and plenty of street parking for any other cars. We can accommodate up to 6 people & 1 dog by arrangement
We hope you enjoy our site and that it provides all the information you need. If however, you need further information or you wish to make a reservation, please feel free to contact us.
We have collected a number of comments from some of our previous guests. To view them, click here


text:
Delicious Baked Spinach-Cheese Casserole
This is an amazing spinach dish, if you are a spinach lover (like me) you are guaranteed to enjoy this one!
butter, spinach, garlic, nutmeg, onions, black pepper, +flour, +mushroom, +gruyere cheese, +half and half, +parmesan cheese, +salt
www.recipezaar.com - Similiar recipes
Creamed Spinach (Boston Market Clone)
Awesome creamed spinach recipe, better than Boston market.
black pepper, butter, spinach, garlic, nutmeg, onions, +flour, +cream cheese, +half and half, +parmesan cheese, +salt, +water
www.recipezaar.com - Similiar recipes
Egyptian Style Spinach (Sabanek)
This is so good, especially on a cold winter day. Its a very hearty and savory dish. You could also add a squeeze of fresh lemon to bowl before serving,...
butter, spinach, garlic, nutmeg, onions, black pepper, +cube chicken bouillon, +coriander, +cumin, +salt, +tomato paste, +tomato
www.recipezaar.com - Similiar recipes
Super Spinach Pie
"This pie DEFINITELY lives up to the name SUPER spinach pie."
black pepper, garlic, nutmeg, onions, spinach, butter, +potato, +carrot, +cottage cheese, +olive oil, +salt, +phyllo dough
allrecipes.com - Similiar recipes
Hot Cheese, Artichoke And Spinach Dip Recipe
spinach, butter, garlic, heavy cream, nutmeg, black pepper, +flour, +parmesan cheese, +lemon juice, +milk, +monterey jack cheese, +salt
www.cdkitchen.com - Similiar recipes
Chicken And Spinach Alfredo Lasagna Recipe
butter, garlic, heavy cream, onions, black pepper, spinach, +mozzarella cheese, +mushroom, +olive oil, +parmesan cheese, +ricotta cheese, +chicken
www.cdkitchen.com - Similiar recipes
Zucchini And Sausage Casserole Recipe
This is a great buffet dish or it can be a main course for a light supper. Prep:30m
garlic, heavy cream, yellow squash, onions, black pepper, butter, +bread crumbs, +cheddar cheese, +eggs, +sausage, +pecan, +hot sauce
www.grouprecipes.com - Similiar recipes
Broccoli - Mushroom Quiche
onions, heavy cream, spinach, nutmeg, butter, black pepper, +swiss cheese, +tomato, +eggs, +parsley, +parmesan cheese, +salt
www.cooks.com - Similiar recipes
Sage and spinach polenta with roasted cherry tomatoes
onions, garlic, spinach, nutmeg, butter, black pepper, +olive oil, +polenta, +water, +manchego cheese, +sage, +cherry tomato
www.bbc.co.uk - Similiar recipes
Spinach Tarte
spinach, butter, onions, garlic, nutmeg, black pepper, +mushroom, +yogurt, +sour cream, +cheddar cheese, +eggs, +worcestershire sauce
recipe.aol.com - Similiar recipes
Can't find what you are looking for? Try our custom google recipe search:
Custom Search
Your Ingredients:
Legend: click ingredients to include or exclude
have this
need to use this
exclude this


text:
$ 86.00
This lovely linen apron and tea towel set has a bright and colorful personality. The linen has a luxurious touch and the strength and sturdiness to wear well, making it a wonderful long-lasting apron. We've combined it with the coordinating Basket Stripe tea towel for this special gift set.
The apron has a loop of fabric on the front for keeping the companion towel handy, and cross-back ties for a comfortable fit. A $94 value, this set is very specially priced to make great gift-giving easy.
- 1 Kitchen Apron in fern linen with slate grey cotton twill ties
- 1 Basket Stripe tea towel, fern ink on oyster linen
- Designed, cut, sewn and screenprinted in the San Francisco.
- Gift wrapping is available, and free!


text:
Ship infoPrintDownload PDF
IMO number | 6717899 |
Name of the ship | CONTINENTAL LOTUS |
Type of ship | BULK CARRIER |
Gross tonnage | 29966 tons |
DWT | 53346 tons |
Year of build | 1967 |
Builder | SIAG NORDSEEWERKE - EMDEN, GERMANY |
Last known flag | INDIA |
Class society | AMERICAN BUREAU OF SHIPPING |
Former names | NAROTTAM MORARJEE until 1969 ORM JARL until 1967 |
Ship photos
They say "A picture is worth a thousand words". Help us build up ships photo database by adding photos of ships you served on. Register with your account, search for ship by IMO number or ship's name and click on (UPLOAD PHOTOS) above. By doing this you will contribute to our database bringing ships you served on closer to maritime community.
You keep the copyright to your images, and will be credited below each photo.


text:
Open Access (OA) refers to free, immediate, permanent, online access to digital full-text scientific and scholarly material, primarily research articles published in peer-reviewed journals. There are limited copyright and licensing restrictions on open-access articles, meaning that anyone with Internet access may read, download, copy, and/or distribute them. A primary advantage to authors who make their articles openly accessible is that their research impact is maximized due to a wider audience.
The WVU Libraries are committed to providing open access to research for anyone anywhere. We have established an Open Access Author Fund (OAAF) for scholarly content published by WVU authors. While we encourage you to include publication fees in grant requests and use University funding, such as the Eberly College Subvention Fund whenever possible, we welcome you to request fees for open access publications as a last resort when no other source of funding is available. The fine print is available on our Open Access Author Fund page.
The WVU Libraries have negotiated reduced fees if you publish your work in the following open access journals:
Beware of journals seeking your contributions via e-mail and then levying a fee for publication. These journals will not be listed in the Directory of Open Access Journals and will not have signed on to the various open access initiatives. Other warning signs:
Still not sure if Open Access is for you? Learn about:
Other great resources for open access information include:


text:
Canon PowerShot A2300
Enough of an improvement over a cell phone camera…
Source: received it as a sample, freebie, or prize (The nice Trailspace people)
Enough of an improvement over a cell phone camera to merit taking along. Update: It just broke after ~6 months.
- Small
- 5x optical zoom
- High quality pictures
- Makes decent short movies
- Intuative navigation of features
- Long battery life
- Battery must be removed to charge
- Lens Error? It's now Broken
For a while I have been using the camera on my cell phone because carrying a separate camera seemed like a waste of space. Finally small digital cameras are, in my opinion, good enough to justify the space they occupy in my pockets.
Back in the days of film (remember that stuff?) I used to take my SLR everywhere and even developed my own film and prints, now I just want something easy to snap good pictures so I can show my friends and family all the cool things we get to do. I might be able to find my old light meter if I looked but when I do, I'll sell it. Maybe to a museum ;)
I received the Cannon PowerShot A2300 HD as a prize from this cool outdoor website, you might have heard of it: Trailspace.
What I like most about this camera is the simplicity to use. Often when I want to snap a pic of something I need to get the camera out of my pocket in a hurry. Some cameras take so long to start up that the moment is gone before the camera is ready. Can anyone relate? The PowerShot turns on quickly enough to get the shot.
I wish I could just plug in the camera with a USB to charge it, but alas, I have to remove the battery and put it in a battery charger. I charged it a half star for this. The upside is that the charge lasts for over a hundred pictures before recharging is necessary.
The PowerShot not only takes 16.0 mp photos but also records HD movies, maybe not the best quality for a feature film but adequate for my needs. The camera has the same functions that other cameras have, it recognizes faces and fixes red-eye, etc but it has one of the better auto settings so I really don't need to worry if my subject is back-lit or moving fast, the camera can tell and adjusts accordingly. This site compresses pictures to save space but I'll add some pictures below to detail the quality the camera produces.
Small size. This picture was NOT taken with the PowerShot, OBVIOUSLY!
In shadows it figured out the exposure pretty well. This picture would be impossible with some cameras.
A couple inches from the lens. No idea what this bug is called.
Evidently snow is hard for some cameras to shoot.
Lights and shadows with colors
I have yet to catch fast moving action with this camera in the past 9-10 months, but if it works as well as it does in other situations I won't worry.
UPDATE: This camera just broke. Last month (June 2013). My oldest son was using it and might have got sand in it and when I turn it on it says "Lens Error" and shuts down. Cannon says they can fix it but it might cost more than the camera is worth. Grrr! I deducted some stars.
Perfect size for hiking or any time you don't want…
Source: bought it new
Price Paid: $110
Perfect size for hiking or any time you don't want to be weighed down but still want to be able to get some great shots!
- Very small and lightweight
- Takes very good pictures for its size and capabilities
- Good battery life
- Speed for shots a bit slow for action shots
Perfect size for hiking or any time you don't want to be weighed down but still want to be able to get some great shots! I purchased this camera to take with me on a week long hiking trip because the camera that I owned was too large and heavy to carry.
After initially getting used to it, I find it to take very good pictures for the size and weight. It very easily slips into almost any pocket easily and the battery life is actually pretty good. I have to admit the first time I used it, I didn't turn it off properly and discovered the batteries were dead when I went to use it, however, that was definately "operator error" on my part and I haven't had an issue with it again since then. As is typical with cameras of this type, I find the speed to be a little bit slow for action shots but since I primarily use it for scenery, etc., this isn't an issue for me.
I would recommend this camera for anyone needing a small, lightweight camera that takes good pictures for a reasonable price!
Similar Products
Canon PowerShot A2300
The Canon PowerShot A2300 is not available from the stores we monitor.
If you're looking for a new outdoor gear, check out the best reviewed current models.


text:
We'd like to hear from you...
Print Page
© Mr Brian Jenkins LRPS
IoE Number: 52667 Location: CHURCH OF ST NICHOLAS, CHURCH LANE (north side) ARRINGTON, SOUTH CAMBRIDGESHIRE, CAMBRIDGESHIRE Photographer: Mr Brian Jenkins LRPS Date Photographed: 01 May 2000 Date listed: 22 November 1967 Date of last amendment: 22 November 1967 Grade I
The Images of England website consists of images of listed buildings based on the statutory list as it was in 2001 and does not incorporate subsequent amendments to the list. For the statutory list and information on the current listed status of individual buildings please go to The National Heritage List for England.
ARRINGTONCHURCH LANETL 3250 (North side)15/3Church of
ARRINGTON CHURCH LANE TL 3250 (North side) 15/3 Church of 22.11.67 St Nicholas I Parish church. C13 chancel and nave, and slightly later C13 west tower. Nave aisles removed later medieval period; C16-C17 bell stage to tower and repaired blocking of nave arcade. Restored 1894 and c.1985. Coursed clunch, fieldstone and clunch and some limestone dressings. Plan of west tower, nave and chancel, south porch and north vestry. West tower of three stages with timber spire, leaded embattled parapet. Ground and first stages C13, with two stage angle buttressing. West window of two lights restored in two centred arch with Y-tracery. Bell stage restored C18. Red brick with clunch quoins and two light openings in segmental arches of brick. On the east wall and returned to north wall is the gable of the original medieval nave roof. South wall has the nave arcade of three bays. Two centred arches of a single chamfered order visible on the interior, on octagonal columns with moulded capitals. The columns have been much altered and the bays have been blocked with C16-C17 red brick. One c.1400 window, reset, of two trefoil light with reticulated tracery to one bay. The chancel wall is now continuous with the outer wall of the nave. Coursed clunch with some limestone to footings. Two c.13 windows of two lights with Y-tracery to the north and south walls. The east wall has a window of three lights in two centred arch with intersecting tracery. Single stage c.13 buttressing to east end of chancel. Interior: the tie beams of the roof are later replacements. The c.13 tower arch is two centred and has two chamfered orders. C13 double piscina in south wall of chancel. Moulded round arch rising from responds consisting of attached shafts with moulded caps and bases. The arch is intersected by two uniform half arches springing from a central shaft, now removed. Two octofoil drains. The whole is within a moulded frame. Font, c.13. Limestone. Tapering bowl with roll moulded lower edge, round stem and plinths with chamfered upper edge. RCHM: West Cambs mon (1) Pevsner: Buildings of England p293


text:
The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Condition |
Hypoxia Lactic Acidosis |
Study Type: | Observational |
Study Design: | Observational Model: Cohort Time Perspective: Cross-Sectional |
Official Title: | The Gene Expression Studies of Tumor Microenvironments and Their Roles in Tumor Progression |
Enrollment: | 0 |
Study Start Date: | September 2009 |
Study Completion Date: | September 2012 |
Primary Completion Date: | September 2012 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
The purpose of this study is to analyze the gene expression patterns associated with various microenvironmental stresses in tumors to understand their roles in tumor progression and treatment responses. To achieve this goal, we will perform gene expression analysis of the tumor samples collected from an IRB-approved study (IRB #: 4516-05-2R2) International Phase III Study of Chemoradiotherapy versus Chemoradiotherapy Plus Hyperthermia for Locally Advanced Cervical Cancer directed by Dr. Mark Dewhirst. We will correlate the gene expression signatures of different microenvironmental stresses with the measured physiological parameters to understand their role in tumor progression, treatment response and clinical outcomes.
Detailed Description:
In the first part of the proposal, we will determine the cellular responses to various microenvironmental factors (such as lactosis, acidosis, hypoxia, glucose deprivation) in cultured epithelial cells (commercially obtained) making use of DNA microarray analysis. From the analysis of these microarray assays, we will obtain the gene signatures reflecting how cells respond to these environments stresses. These gene signatures will be used to analyze and annotate the gene expression patterns in the tumor samples and whether hyperthermia will affect the physiological parameters and the corresponding gene signatures.
In the second part of the proposal, we will work with Dr. Dewhirst to perform gene expression study of cervical cancer samples from a phase III, multicenter, randomized clinical trial (IRB 4516-05-2R2). The subjects will de-identified and we will not obtain directly the PHI of the subjects in this trial. Subjects will be randomized to chemoradiotherapy alone or chemoradiotherapy + hyperthermia. For subjects randomized to hyperthermia, heat treatments will be administered concurrently with chemotherapy once weekly during the course of external beam radiation. In the hyperthermia suite, catheters will be placed in the cervical os, vagina and rectum for internal temperature monitoring. Hyperthermia will be given externally to the pelvis and abdomen using the BSD Sigma 60 ,Sigma Eye or Sigma Ellipse systems. Initial power will be limited to less than 1500 watts with phase and amplitude adjusted for equal surface electric fields in each quadrant of the applicator. Heating will continue for 60 minutes after average cervical os or interstitial temperatures of 40°C have been achieved, or for a maximum total duration of 90 minutes, whichever is longest. The bolus temperature will be 37° at initiation of power and will be reduced as necessary for patient comfort and/or to help maintain oral temperature of 38.5C. Power will also be reduced or treatment will be stopped at the patient request, or due to intractable pain, nausea or vomiting, if normal tissue temperature rises to 44°C, pulse > 160, BP > 180/100 or < 90/50, altered mental status, or systemic temperature > 38.5°C.
A. The research materials will include the tumor biopsy obtained before and after HT treatments to be used for gene expression studies as well as for the IHC and ISH studies to the findings from our microarray analysis. We will also obtain the information on the tumor physiological parameters information measured in these tumors.
B. The data of the tumor physiological parameters measured and the response to treatments and other clinical outcomes of these patients will also be acquired.
C. Only the physicians taking care of the patients will have access to the patient identifies and other Protected Health Information (PHI). All information will be de-identified and remain anonymous during the studies.
D. The specimens will be collected when the patients undergo medical care for their respective diseases. No new materials or data will need to be collected specifically for this proposal. These biopsies and physiological measurements are included in the original proposed clinical trials.
Ages Eligible for Study: | 18 Years to 50 Years (Adult) |
Sexes Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Invasive cervical carcinoma (small cell histology excluded)
- Age 18 or over
- FIGO stage IIb-IVa
- ECOG/WHO 0,1, or 2, or >/= 70% respectively
- WBC >/= 3,000, platelets >/= 100,000
- Hgb>12.0 g/dL or >7.5 mmol/L, with transfusion if needed
- Serum bilirubin </= 1.5 times ULN, transaminase </= 3 times ULN
- Calculated creatinine clearance > 60 ml/liter (Cockcroft)
- Para-aortic adenopathy absent or 1.5 cm in greatest dimension on CT/MRI
- No history of myocardial infarction in the last 6 months
- No symptomatic angina pectoris
- Any past history of coronary artery disease must require assessment and clearance by the PCP and/or cardiologist
- Negative pregnancy test in patients under 50
- Written informed consent
Exclusion Criteria:
- Patients who have undergone surgical resection of the primary tumor are not eligible (Limited surgical resection of pelvic nodes without TAH is acceptable)
- Patients with pacemakers or implanted defibrillators
- Patients with significant metallic foreign bodies (i.e. hip replacements, bone metallic rods, orthopedic plates, etc.)
- Prior radiotherapy or chemotherapy
Please refer to this study by its ClinicalTrials.gov identifier: NCT00638040
United States, North Carolina | |
Duke Medical Center | |
Durham, North Carolina, United States, 27708 |
Principal Investigator: | Jen-Tsan Chi, Ph.D. | Duke University |
Responsible Party: | Duke University |
ClinicalTrials.gov Identifier: | NCT00638040 History of Changes |
Other Study ID Numbers: |
Pro00006979 R01CA125618 ( US NIH Grant/Contract Award Number ) 9070-07 |
Study First Received: | March 12, 2008 |
Last Updated: | July 9, 2014 |
Keywords provided by Duke University:
hypoxia lactate pH tumor microenvironments survival |
Additional relevant MeSH terms:
Anoxia Acidosis Acidosis, Lactic Signs and Symptoms, Respiratory |
Signs and Symptoms Acid-Base Imbalance Metabolic Diseases |
ClinicalTrials.gov processed this record on March 24, 2017


text:
Do some Excel Work
This project received 26 bids from talented freelancers with an average bid price of ₹6062 INR.
Get free quotes for a project like thisProject Budget
₹1500 - ₹12500 INRTotal Bids
26Project Description
Anything in excel which requires little effort
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!
Sign Up Now- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
Fyll inn postnummer, kommune eller fylke.
The Norwegian Ombudsman for Children has established an expert group of young survivors from the terrorist attack on Utøya 22nd of July 2011. The group consists of 9 children and young people from different parts of Norway. During the meetings with the Ombudsman they have discussed several issues related to the aftermath of the massacre, one of which is how the media has been handling the situation.
The expert group understand that the media interest and coverage of the court case will be extensive. Therefore , the young survivors would like to call for the media's consideration on some points during interviews and covering of the case.
Read more in the request from the Norwegian Ombudsman for Children.
Siden ble sist oppdatert: 13.04.2012, kl. 13:25
Så bra! Takk for at du gav tilbakemelding.
Det oppsto dessverre en feil. Sjekk at kommentaren din bare består av tekst og prøv deretter på nytt. Kontakt oss dersom problemet vedvarer.
Takk for at du hjelper oss!


text:
Friday, 15 February 2013
First 'An Adventure In Time and Space' Promo Pic Released!
The first promo picture for the 50th anniversary bio-doc has been released, courtesy of Radio Times. The picture shows David Bradley as William Hartnell, with Lesley Manville playing Hartnell's wife Heather.
Subscribe to:
Post Comments (Atom)


text:
Blu-ray players and portable media centers weren't the only thing on Royal Philips Electronics' mind today, as the company also revealed a new pair of flash-based GoGear DAPs as part of the "Holidays in June" campaign. We've already seen Philips do the flash thing before -- not to mention the hard drive thing -- but with the nano-like SA9100 and SA9200 the company has chosen to drop the low capacities of old in favor of 1GB and 2GB of storage, respectively. Both models also sport color screens for viewing photos and album art, a backlit touchpad for navigation, FM tuner, voice recorder, and a rechargeable battery promising 14 hours of playback, and both devices are also PlaysForSure-compliant. You'll be able to pick up the higher capacity model for around $200 when it hits stores next month, while the single gig unit will cost about $150 at its scheduled September release.
Read- GoGear SA9100
Read- GoGear SA9200


text:
more soon...
Quick links: NewsBiscuit Home • Chat Room • Writers' Room • Top Ten
Consternation as Lincoln movie contains no references to A46 bypass
(3 posts) (3 voices)
Posted 4 years ago #
Film didn't mention the level crossing choking traffic in the city's high street for Christ knows how long in every hour either! Have some local reference stars
Posted 4 years ago # -
I wonder if Baggy will be in it. Big tissue!
Posted 4 years ago #
You must log in to post.


text:
Daisys Dream Candy Wrapper, Item# CB3165S
Note: Sparkles are simulated and will not light up.
Daisys Dream Candy Wrapper, Item# CB3165S
Note: Sparkles are simulated and will not light up.
Daisy's Dreaming Reply Card Set
Daisy's Dreaming Thank You
Daisy's Dreaming Envelope Seals
Daisy's Dreaming Return Address Labels
What would sweeten your special occasion more than a customized Candy Bar Wrapper with a delicious chocolate bar inside? Recipients will be thrilled with this unique favor!
"Daisy's Dream" features a sleeping baby girl, with light brown hair. She is lying on her tummy on a whitish-light grey shag rug. Large Daisy flowers in pastel colors - mint green, pink, yellow, purple, & blue, are located behind the baby.
Wrappers come unassembled, however we will email you assembly instructions.
The wrapper is designed to fit a 1.55 oz. Hershey's® Candy Bar. Note: foil is not included. Our wrappers fit directly over the Hershey's® Candy Bar Wrapper.
Due to the hot summer months and the chance of chocolate melting while in transit, we temporarily do not offer the Hershey's Chocolate Bars with the wrappers.
You will be able to select the typestyle and ink colors to use for your personalized text during the design process. Start by clicking on the green CUSTOMIZE WORDING button. We recommend using the default typestyle and ink colors.
Item Type: | Candy Bar Wrapper |
Candy Bar Wrapper Dimensions: | 5.50 X 5.60 (W x H) |
Printing Process: | Digital Press |
Paper: | Coated Wrapperstock |
Typestyle Shown: | Lucida Calligraphy |
Matching Ink Color: | Purple and Magenta |


text:
(151 quotes found)
"[Georgia Tech is] much better than their record shows. They're getting better and better as they're moving along. Then, of course, Florida State at home on Sunday -- same situation. These are very good teams that I think are better than their record shows they are."
Sylvia Hatchell
"We got a couple of steals and we got a couple rebounds. That made the difference."
"There's going to be some really good basketball here."
"We have watched Riverside, and they are a very good motion offensive team. It's a young team that has a lot of eager players, so we know we have to be ready."
"I've watched some (television) games this season at my house. Some of these games, it's like watching paint dry. And I don't like that. I want the game to be fun and exciting. I want people to want to watch women's basketball."
"You could make a great Final Four just from the teams in our regional alone. Everyone seems to agree it's the toughest. But, we've played great teams all year and we'll be prepared. I think the strength of this bracket will help motivate our team."
"She's a winner. She's just a tough little kid and she finds a way to win."
"I felt like somewhere down the road we would play Tennessee. I expected it to be in the Final Four. It's a shame that we have to play so early in the bracket."
"I don't think the other No. 1 seeds are having to do this."
"This is the second year we've had to do this, and this year we are the No. 1 seed yet we're having to play a team like Vanderbilt on the road in the second game."


text:
This section contains 580 words (approx. 2 pages at 300 words per page) |
Magnolias are interesting flowers. Each flower has many petals that all meet in the center. In every room shown in the film, there is at least one picture of flowers. Throughout the film, we are reminded that everyone is connected in some way. Every character has some connection to the film What Do Kids Know? Thus, they all have connections to each other as well. The magnolia symbolizes that they are all connected.
The magnolia symbolizes the interconnectedness all of us. No matter how alone we may feel at times, we are always somehow connected to others. Anderson tends to focus on the isolation of people, especially those in the suburbs, and how eventually, in order to survive, people must come to terms with their lives and learn to live in harmony with others. By the end of the film every person has begun re-evaluating his or her...
This section contains 580 words (approx. 2 pages at 300 words per page) |


text:
Konami Announces The Silent Hill Experience for PSP
Though unfortunately not another game in the classic horror franchise, The Silent Hill Experience instead pursues the route of animated comic. Somewhat akin to the "interactive dramas" that Japan has been used to for years, SHE comes packed with 6 15-minute long moving comics. That means that the viewer will move through a comic-style narrative with various moving picture elements, artistic panel transitions, and pop-up speech bubbles layered against the background of creator Akira Yamaoka's haunting soundtrack.Konami has expressed interest in this unique narrative form as of late considering their other golden child, Hideo Kojima, plans to release Metal Gear BD (also for the PSP) sometime later this year. BD comes as the result of a collaboration between Kojima and Sin City creator Frank Miller.
Though it has yet to be seen whether or not American audiences will take to The Silent Hill Experience's unique form of storytelling, it comes with DVD-style special features such as a soundtrack selector, interviews, movie and game trailers, and other hidden content. At the right price, it could be a compelling adjunct to a Silent Hill fan's game collection.
1/26/2006 Cavin Smith
Put this on your webpage or blog:
Email this to a friend
Follow PSX Extreme on Twitter


text:
Tony Rosenthal Cube Maquette, 1966 Plywood 22 x 17 x 17 inches Collection of Cynthia Rosenthal © Tony Rosenthal/Licensed by VAGA, New York, NY
The entire contents of The Official Tony Rosenthal Website including all images and text are copyright ©Tony Rosenthal. All Art created by Tony "Bernard" Rosenthal, including all Sculpture located in public places is ©Tony Rosenthal and protected by the Visual Artists Rights Act. Permission is required to reproduce, photograph, sell and/or use any Art created by Tony Rosenthal, in any manner, and for any reason, from VAGA, the copyright agent for Tony Rosenthal.


text:
Hello and welcome to "What's New" on EtsyMetal team.
I am very proud to show you what out team members created this week.
Cynthia Del Giudice Sarah Hood Jewelry
LSueSzabo 2Roses
deborah lee taylor Peculiar Forest
Kate Jones Jewelry Laura jane Bouton
Iacua SCJJewelryDesign
The EtsyMetal mark is your assurance of hand made craftsmanship, quality, and that the artist follows ethical trade practices.
Have a great weekend ,


text:
Hey guys here's three new pieces I've just completed. I've actually had some time lately to work on my own work. Enjoy!!!! The first two are really small the pink one is 10"x7" and the orange and prurple one is 12" square. The last one is kinda big about 4.5' x 2'.
Wednesday, October 24, 2007
Monday, October 22, 2007
So I went to my internship today and worked for six hours. I finshed photo documenting the flat files as well as assisting with some sales and routine gallery tasks. Well as I am a painting assistant to Joe, the owner of the gallery and professional artist himself, I worked another 6.5 hours in his studio painting letters and mixing colors and things of that nature. It's really nice how much he's allowing me to do with his own work. But man o' man was it a long day. Now I'm in my studio getting ready to work on my work. I've started some really small delicate cut out pieces that are all constructed from card stock and I really like the way they are going. I'm just trying to get as much done as possible in the studio b/c I have a studio visit with Joe on the 31st of Oct. Well back to work hope all is well wherever you may be. Until next time................
Subscribe to:
Posts (Atom)


text:
Is the track drying out? Can you risk a puncture? Is your technical riding skill excellent? OK, then you are ready for the Schwalbe Furious Fred Evo Pace Star Tubeless Folding 26 Mountain Bike Tyre. With a tread design that is optimized for speed, minimal material keeping the weight down, 127-epi- Evo-carcass and PaceStar Triple Compound for grip this is Schwalbe lightest and fastest mountain bike tyre.
Check stock and price


text:
Set in Boston in the 1770's, this is the story of a silversmith's apprentice that burns his hand. Since his trade can't be taken on by someone without a useful right hand, he has to find some other way to earn the food he eats and the bed on which he sleeps. It seems that all his friends have turned against him. But then hope shines like the sun through clouds and suddenly his future brightens. This rebellious young man is a message carrier for the Sons of Liberty. The book Johnny Tremain has a very surprising ending.
Rating: *****


text:
Login Required
JPG+ Required
Collections are a JPG+ feature. You must be a JPG+ member to create new collections and to add photos to collections.
Sign up for JPG+ to start using collections now!
Photo license: © All rights reserved
2 responses
Artur Bednarz said (4 Jun 2010):
I like it. Nice soft shades.
Joseph Malinao (Deleted) gave props (4 Jun 2010):
beautiful light and subject.
Also by Mariam Sitchinava


text:
Pizza Project
We are slowly forming a routine here: school, lunch, a bit of time outside, some indoor play, dinner, bath and bed. It's so much easier to prepare dinner if the kids are involved in the process; otherwise, they're inevitably chasing each other around, which almost always ends in tears. Pizza is a fun and no-fuss way to get them involved; we could have pizza every night of the week. Last night we used refrigerated pizza dough and cut shapes out of the cheese. We scattered Italian sausage coins over half the pizza, too.
I set the dough out to rest (it was a bag of Trader Joe's dough, which is a lot like homemade). I also pricked Italian sausage links, broiled them for a few minutes, then cut them in disks. We floured our hands and work surface, patted and stretched the pizza out thin, spread on some tomato sauce and made pictures with the cheese. (I forgot to brush the crust with oil, which would've been a nice touch for a brown crust.) Ten minutes in a 450-degree oven and it was done.
Kids can help with stirring and assembly, or with cutting up fruit or soft cheese. Below, a few good food projects for young kids (with a parent handling the hot stuff, of course):
Pasta with Tomatoes and Mozzarella
Fruit Salad with Yogurt Dressing
— Kim Walker


text:
This section contains 1,650 words (approx. 6 pages at 300 words per page) |
ABELARD, PETER (1079–1142), logician and Christian theologian. Peter Abelard was born at Le Pallet, outside of Nantes (Brittany). He chose to pursue the study and teaching of logic and journeyed to hear the lectures of Roscelin of Compiègne at Loches (Anjou); he later went to Paris to attend classes with the renowned dialectician William of Champeaux. His celebrated controversy with William on the question of universals revealed the persuasiveness of Abelard's quick mind and penetrating insight. Abelard's own teaching career began in Melun and Corbeil to the south of Paris, but he soon returned to Paris, teaching at Nôtre-Dame and at Mont-Sainte-Geneviève, just across the Seine from the capital.
Abelard's interest in applying twelfth-century methods of dialectical inquiry to Christian doctrine led him to study theology at Laon (c. 1113) with Anselm of Laon, who was recognized for his lectures on patristic teaching and for...
This section contains 1,650 words (approx. 6 pages at 300 words per page) |


text:
| Thread Tools |
4th February 2011, 16:59 | #1 |
Madshrimp Join Date: May 2002 Location: 7090/Belgium
Posts: 78,970
| Patriot Viper Xtreme Division 2 DDR3-1866 8GB Dual Channel Memory Kit A little while ago we took a look at Patriots Viper Xtreme triple channel memory that is designed for Intel X58 systems. Today we are checking out the Viper Xtreme Division 2 Edition memory which is designed for Intels 2nd generation Sandy Bridge Core processors. This memory has been rigorously tested and validated on the Intel 6 Series platform to achieve maximum performance and stability. The Division 2 memory has all of the same features as the original Viper Xtreme memory like the 6 gram copper core and aircraft-grade aluminum heatspreaders. Today we will be puttin g the 8GB DDR3-1866 kit to the test. http://www.thinkcomputers.org/patrio...ry-kit-review/
__________________ |
Thread Tools | |
| |


text:
Vintage: | 2010 |
Appellation: | Napa Valley |
Harvest Date: | September 17th, 2010 |
Acid: | .67 |
Aging: | 9 months- Mixed French Oak |
Alcohol %: | 14.1 |
Tasting Notes:
Since 1965 the Steltzner family has been dedicated to growing grapes of exceptional quality. This Chardonnay is grown on our Oak Knoll Estate; in the well drained gravely soil of Dry Creek, on the west side of the Napa Valley. The nose of this wine starts with Tropical fruit and sweet melon aromas, which mingle with sweek oak and vanilla notes. On the palate this wine is rich and creamy, and well balanced. Honeydew melon and citrus show bright up front, with the creamy sweet oak and vanilla notes from the barrels showing on the end, just as with the nose.


text:
Josh Thompson Cuts Off His Ponytail
Josh Thompson is a new man with a new look!
Josh Thompson is a new man with a new look!
Making his first public appearance since his father's death and a stay in rehab, Trace Adkins took the stage for a surprise performance at the Grand Ole Opry on Tuesday (March 11).
Turning a personal tragedy into a hit record is tricky, and not just for all the normal reasons that it's difficult to make a song into a hit. Artists who write a great personal song may be hesitant to record it for months or years. Taste of Country writer Billy Dukes considers three powerful songs and three artists who dealt with the personal tragedies that inspired them in very different ways.
Trace Adkins' father has died. Aaron Doyle Adkins, a former mill worker, is remembered as a quiet and hardworking man who bestowed his love of country music on his oldest son. He died on Saturday (Feb. 1) at the age of 71.
Trace Adkins has reportedly stepped away from treatment in a Florida rehabilitation facility to be with his ailing father, Aaron. Sources say he needed to be at his dad's side, but it's not clear if the illness is life-threatening.
Songwriting may be part of Trace Adkins' alcohol rehabilitation, as he stepped away from treatment to buy a new guitar over the weekend.
Country Cruising has partnered with Trace Adkins and his Nashville team to allow the January cruise attendees see all the performances that they unfortunately missed on this month's ship.
While Trace Adkins is bravely facing recovery following a relapse with alcoholism, his fans can keep him in their thoughts and look ahead to brighter things in the future, including the singer's role in an upcoming Hollywood flick. The trailer for 'Mom's Night Out' debuted this week (Jan. 21) and finds Adkins as a big, tough guy with a huge heart.
Neal McCoy expressed his sympathies for Trace Adkins and praised the rest of the Country Cruising lineup after the ship's headliner left for rehab last week.
Earlier this week, Trace Adkins announced a second stint in an alcohol rehabilitation facility. He fell off the wagon during a cruise he was set to headline. It was his first taste of alcohol in over a decade -- since his last stay in rehab in 2002. While the singer seems to be taking full ownership of what happened on that boat, the incident shines a light on something not talked about very often.
Trace Adkins has taken a step toward recovery, checking into rehab after falling off the wagon in his battle with alcoholism. However, a lot remains unclear about a fight that allegedly occurred between the star and an impersonator onboard the Country Cruising ship this week, which may have led him to check into the facility.
Trace Adkins took his first drink in over a decade, then checked into rehab earlier this week.


text:
Another Clinton enemy audited
Actress Elizabeth Ward Gracen, the former Miss America who had a
fling with Bill Clinton in 1983, was warned to keep her mouth shut about
her experience.
For a long time, she did just that. In fact, she even fled the
country for awhile when faced with questions about her relationship with
Clinton during the early stages of the Monica Lewinsky scandal and the
prospect of being subpoenaed to testify.
She recalls that an anonymous caller tipped her off about the
imminent subpoena. That same caller more recently warned her that if she
didn't keep quiet she would face an IRS audit.
Now the IRS is all over Ms. Gracen — like Bill Clinton when
Hillary's out of town. Her lawyer says she has been deluged with dozens
of letters from the agency claiming she didn't file returns and
threatening to seize her wages and property.
"She pays her taxes," says her attorney, Vincent Vento. "She's really
square. I don't think anybody wants to take on the government. … She
just feels it's completely unfair."
Vento is not shy about stating that this is a political audit all the
"The only person who would benefit would be the president of the
United States, unless there's some other agenda out there," he said.
Within weeks of going public with her story about Clinton last
spring, she was warned to shut up or face an IRS audit. A few weeks
later, the letters from the IRS started coming in, sent to her parents'
house, which is not listed on her tax filings.
Now, what does all this mean? It means that the Clinton "Secret
Police" operation, discussed so often by former aide Dick Morris and
others, is very much alive and well in the White House — at the very
moment this president is facing an impeachment trial.
I can just hear the White House spokesman's reply to such an
accusation: "Why, we'd have to be out of our minds to do something like
that at a time like this." Right! That's exactly what the president's
apologists said when Paula Jones was audited days after rejecting a
settlement offer from Clinton. In fact, Clinton's brazenness has been
his best cover for scandals from the beginning. His henchmen threaten to
break legs. His own employees circulate death lists associated with his
administration. FBI files are passed around among his lawyers. And the
IRS is used against prominent individuals and groups who dare to
criticize or expose corruption.
I know from first-hand experience.
Next month, I'll be in federal court pressing a $10 million lawsuit
against IRS and White House officials for their politically motivated
audit of my organization in 1996. I know my legs are not nearly as nice
as Elizabeth Ward Gracen's, but do you think there's any chance the
establishment press might give such a landmark legal case some
You see, there's a pattern here. These are not random audits. The
list of organizations which have been audited during the Clinton
administration reads like a who's who of the "vast right-wing
conspiracy" Hillary dreams about — Western Journalism Center, American
Spectator, National Rifle Association, Christian Coalition, Concerned
Woman of America, Citizens for a Sound Economy, Center for the Study of
Popular Culture, Chuck Harder's Peoples Network Inc., National Center
for Public Policy Research, American Policy Center, Heritage Foundation,
American Cause, Citizens Against Government Waste, Citizens for Honest
Government, Oliver North's Freedom Alliance and many others.
Besides Paula Jones and Elizabeth Ward Gracen, many individuals who
have had run-ins with the Clinton administration have been targeted as
well. Perhaps the most prominent is Billy Dale, former director of the
White House travel office, fired to create a place for a friend of the
Clintons. All Patricia Mendoza had to do to make it on the list was
shout a remark at the president during a 1996 campaign stop in Chicago.
All attorney Kent Masterson Brown had to do was represent the
Association of American Physicians and Surgeons in demanding Hillary
Clinton's secret health care task force be opened to the public in 1994.
All William Gazecki had to do was edit the documentary "Waco, the Rules
of Engagement." All Shelly Davis, the former IRS historian, had to do
was author a whistleblowing book on the agency called "Unbridled Power."
I could go on and on and on. The coincidences get a little thick,
after awhile.
The question is: Who's more credible today: Elizabeth Ward Gracen or
Bill Clinton? The government has my answer filed in federal court. How
are you going to communicate your answer?


text:
Neurocrine Biosciences Reports First Quarter 2013 Results
May 02, 2013, 16:02 ET from Neurocrine Biosciences, Inc.
SAN DIEGO, May 2, 2013 /PRNewswire/ -- Neurocrine Biosciences, Inc. (NASDAQ: NBIX) today announced its financial results for the quarter ended March 31, 2013. For the first quarter of 2013, the Company reported net loss of $12.1 million, or $0.18 loss per share, compared to a net loss of $0.9 million, or $0.01 loss per share, for the same period in 2012. This $11.2 million change in operating results is primarily due to lower revenue recognized during 2013 under the Company's license agreements with AbbVie and Boehringer Ingelheim. The sponsored research and development segments of both of these agreements concluded, as scheduled, during 2012.
The Company's balance sheet at March 31, 2013 reflected total assets of $183.9 million, including cash, cash equivalents, investments and receivables of $176.9 million compared with balances at December 31, 2012 of $196.0 million and $188.3 million, respectively.
"AbbVie has made great progress with elagolix. The initiation of this Phase IIb study in uterine fibroids is another significant milestone for this program," said Kevin Gorman, Ph.D., President and Chief Executive Officer of Neurocrine Biosciences. "Our VMAT2 program also continues to move forward in two Phase IIb tardive dyskinesia studies, with an End of Phase II FDA meeting anticipated later this year."
Revenues for the first quarter of 2013 were $0.7 million compared with $11.3 million for the same period last year. The entire $10.6 million reduction in revenue is due to the successful completion of the sponsored research and development segments of the Company's license agreements with both AbbVie and Boehringer Ingelheim during 2012, as scheduled.
Research and development expenses increased to $10.3 million during the first quarter of 2013 from $9.4 million during the same period in 2012. This increase was primarily a result of higher external clinical development expenses related to the ongoing Phase IIb studies of the Company's VMAT2 inhibitor, NBI-98854. General and administrative expenses decreased from $3.7 million in the first quarter of 2012 to $3.4 million for the first quarter of 2013, primarily due to lower professional services costs and continued cost mitigation efforts.
Pipeline Highlights
Elagolix Update
AbbVie is currently conducting the initial Phase III study of elagolix for endometriosis, the Violet Petal Study. The study is a 24-week, multinational, randomized, double-blind, placebo-controlled study designed to evaluate the safety and efficacy of elagolix in 875 women, age 18 to 49, with moderate to severe endometriosis-associated pain. Approximately 160 sites in the United States, Puerto Rico and Canada are conducting this study.
During March 2013, AbbVie initiated a Phase IIb study of elagolix in uterine fibroids. This study is assessing uterine blood loss in 280 women with heavy uterine bleeding due to uterine fibroids.
VMAT2 Update
The Company is currently conducting two Phase IIb studies of its VMAT2 inhibitor, NBI-98854.
The Kinect Study is a 120 subject, placebo-controlled, double-blind, parallel-design, multiple-dose, 12-week study assessing six-week dosing of NBI-98854 against placebo, followed by six weeks of open-label treatment with NBI-98854 in tardive dyskinesia patients with underlying schizophrenia or schizoaffective disorder. The primary endpoint is the Abnormal Involuntary Movement Scale (AIMS) at the end of the first six weeks of dosing. The study will also incorporate a capsule formulation of NBI-98854. Top-line data from the placebo-controlled portion of this study is expected in the third quarter of 2013.
The Kinect 2 Study is a 90 subject, placebo-controlled, double-blind, parallel-design, multiple-dose, six-week study assessing NBI-98854 against placebo in tardive dyskinesia patients with underlying mood disorders, schizophrenia and schizoaffective disorders, and gastrointestinal disorders. The primary endpoint is the AIMS at the end of the six weeks of dosing. Top-line data from this placebo-controlled study is expected to closely follow the top-line results of the Kinect Study.
The Company anticipates an end of Phase II meeting for NBI-98854 in tardive dyskinesia to be held with the FDA in the fourth quarter of 2013.
Additionally, the Company has initiated a preclinical study to support the advancement of NBI-98854 into clinical trials for individuals suffering from Tourette's syndrome. Upon successful completion of this preclinical study, the Company anticipates entering Phase I clinical studies in 2014.
Conference Call and Webcast Today at 5:00PM Eastern Time
Neurocrine will hold a live conference call and webcast today at 5:00 p.m. Eastern Time (2:00 p.m. Pacific Time). Participants can access the live conference call by dialing 866-952-1908 (US) or 785-424-1827 (International) using the conference ID: NBIX. The call can also be accessed via the webcast through the Company's website at http://www.neurocrine.com.
If you are unable to attend the webcast and would like further information on this announcement please contact the Investor Relations Department at Neurocrine Biosciences at (858) 617-7600. A replay of the conference call will be available approximately one hour after the conclusion of the call by dialing 800-753-0348 (US) or 402-220-2672 (International) using the conference ID: NBIX. The call will be archived for one month.
Neurocrine Biosciences, Inc. is a biopharmaceutical company focused on neurological and endocrine-related diseases and disorders. Our product candidates address some of the largest pharmaceutical markets in the world, including endometriosis, tardive dyskinesia, uterine fibroids, stress-related disorders, pain, diabetes, insomnia, and other neurological and endocrine-related diseases and disorders. Neurocrine Biosciences, Inc. news releases are available through the Company's website via the internet at http://www.neurocrine.com.
In addition to historical facts, this press release may contain forward-looking statements that involve a number of risks and uncertainties. Among the factors that could cause actual results to differ materially from those indicated in the forward-looking statements are risks and uncertainties associated with Neurocrine's business and finances in general, as well as risks and uncertainties associated with the Company's R & D pipeline and Company overall. Specifically, the risks and uncertainties the Company faces with respect to the Company's R & D pipeline include risk that elagolix, the company's lead clinical program, will fail to demonstrate that elagolix is safe and effective; risk that elagolix Phase III clinical trials will be delayed for regulatory or other reasons; and risks associated with the Company's dependence on corporate collaborators for Phase III development, commercial manufacturing and marketing and sales activities. In addition, the Company faces risks and uncertainties with respect to the rest of the Company's R & D pipeline including risk that the Company's clinical candidates will not be found to be safe and effective; risk that the Company's VMAT2 clinical candidates will not proceed to later stage clinical trials; and risk that the Company's research programs will not identify pre-clinical candidates for further development. With respect to its pipeline overall, the Company faces risk that it will be unable to raise additional funding required to complete development of all of its product candidates; risk relating to the Company's dependence on contract manufacturers for clinical drug supply; risks associated with the Company's dependence on corporate collaborators for commercial manufacturing and marketing and sales activities; uncertainties relating to patent protection and intellectual property rights of third parties; risks and uncertainties relating to competitive products and technological changes that may limit demand for the Company's products; and the other risks described in the Company's report on Form 10-K for the year ended December 31, 2012. Neurocrine undertakes no obligation to update the statements contained in this press release after the date hereof.
Condensed Consolidated Statements of Operations | ||||||||
(in thousands, except per share data) | ||||||||
Three Months Ended March 31, | ||||||||
2013 |
2012 | |||||||
(unaudited) | ||||||||
Revenues: |
Sponsored research and development |
$ - |
$ 2,029 | ||||||
License fees |
730 |
9,238 | ||||||
Total revenues |
730 |
11,267 | ||||||
Operating expenses: |
Research and development |
10,313 |
9,388 | ||||||
General and administrative |
3,392 |
3,671 | ||||||
Total operating expenses |
13,705 |
13,059 | ||||||
Loss from operations |
(12,975) |
(1,792) | ||||||
Other income: |
Interest and other income |
105 |
123 | ||||||
Gain on disposal of assets |
795 |
783 | ||||||
Total other income |
900 |
906 | ||||||
Net loss |
$ (12,075) |
$ (886) | ||||||
Net loss per common share: |
Basic and Diluted |
$ (0.18) |
$ (0.01) | ||||||
Shares used in the calculation of net loss per common share: |
Basic and Diluted |
66,600 |
63,409 | ||||||
Condensed Consolidated Balance Sheets | ||||||||
(in thousands) | ||||||||
March 31, |
December 31, | |||||||
2013 |
2012 | |||||||
(unaudited) |
Cash, cash equivalents and short-term marketable securities |
$158,234 |
$ 173,013 | ||||||
Other current assets |
2,161 |
16,251 | ||||||
Total current assets |
160,395 |
189,264 | ||||||
Property and equipment, net |
1,784 |
1,900 | ||||||
Long-term investments |
17,410 |
480 | ||||||
Restricted cash |
4,335 |
4,335 | ||||||
Total assets |
$183,924 |
$195,979 | ||||||
Current liabilities |
$13,878 |
$ 15,646 | ||||||
Long-term liabilities |
25,093 |
25,961 | ||||||
Stockholders' equity |
144,953 |
154,372 | ||||||
Total liabilities and stockholders' equity |
$183,924 |
$195,979 |
SOURCE Neurocrine Biosciences, Inc.


text:
Alzheimer's Medication Exelon in Patch Form - A Tricky Solution for My Mom
Yesterday, the FDA approved the first skin patch version of Exelon, a drug to treat mild or moderate dementia in patients with Alzheimer's.
The new Exelon patch sounds like a wonderful idea; however, based on my experience with Mom, I don't know whether it would have been an effective treatment. I provide that response due to a 2005 situation when Mom was experiencing chest pains. The doctor couldn't find anything wrong after Mom visited the emergency room; just to be on the safe side, the doctor asked Mom to wear a portable heart monitor for 24 hours in order to see if there were any issues that weren't showing up. Within two hours of returning home, Mom had peeled off the monitor's feeds because she had forgotten why she was wearing it. So in order to be effective in my mother's case, a patch would need to be placed in a location (such as the shoulder) where Mom wouldn't realize it was there and wouldn't be able to physically get to it.
Furthermore, Mom rarely balks at taking pills, having taken some version of them (like vitamins) all of her life. These types of medication also are quickly swallowed and go into her system, so we don't have to worry about any repercussions concerning her memory since these are administered quickly and efficiently by a nurse at her nursing home.
Click to learn more about Exelon and other Alzheimer's medications.
Also read Expert Caregiver Carol Bradley Bursack's SharePost on the Exelon Patch:
Exelon Skin Patch? Delivering Alzheimer's Drugs Through Patches Can Benefit Elders


text:
TEMPLE CITY — BB guns, bullets and inert grenades left in a Temple City church Friday prompted officials to call in the bomb squad, authorities said.
Officials received a call about 3:30 p.m. reporting a possible explosive device left inside the Victory in Christ Church, 5221 El Monte Ave., Los Angeles County sheriff's Sgt. Richard Conti said.
Deputies evacuated the area around the church and called for the sheriff's bomb squad to investigate a box found inside the church filled with suspicious contents.
The bomb squad determined that the box contained BB guns, bullets and grenades that had had the explosives removed, Conti said, and sounded the all-clear shortly after 6 p.m.
Deputies were investigating who left the items at the church and why.