text:
Painting of Shiva in the Shiva temple in Dhulikhel. (542k) | Picture of the Trimurti, the divine Hindu trinity of Brahma (center), Vishnu (left), and Shiva (right) on the Shiva temple in Dhulikhel. (505k) | Lord Shiva, the Destroyer. (621k) | Lord Shiva, the Destroyer on a small shrine in Patan. (551k) | Picture of Shiva de Destroyer on a house in Panauti. (589k) |
Colorful Shiva statue and fountain next to the Jagannarayan Temple in Patan Durbar Square. (626k) | Bronze statue of Nataraja, the dancing Shiva. (419k) | Statue at the Shiva temple on the way to Nagarkot. This statue of a Hindu God is quite unusual. He has the four heads of the Hindu God Brahma. He holds Shiva's Trishula (trident) and the Damaru (drum). He also holds Vishnu's Shanka (conch shell) and Chakra (spinning disk), so he represents all three parts of the Trimurti, the Divine Trinity. (618k) | Statues of the Trimurti (Divine Trinity) in Varanasi, with Shiva on the left, Brahma in the center, and Vishnu on the right. (679k) | Stone figure of Hindu God Shiva on a temple in Khajuraho, India. (855k) |
Kailashnath Mahadev, the world's tallest Shiva statue (44 m (144 ft)) in Sanga, near Bhaktapur. (480k) | Statue of Kala Bhairab (one of the incarnations of Shiva, the Destroyer) at the Lion Gate in Bhaktapur Durbar Square. (684k) | Relief of Kala Bhairab (one of the incarnations of Shiva, the Destroyer). It was carved in the 6th - 7th century, found in the jungle in the 17th century and established in Kathmandu Durbar Square. (592k) | Bronze statue of Ardhanarishvara, half Shiva, half Parvati. (338k) |
Shiva Lingam in the foreground and Nandi, the bull, the carrier of Shiva behind it. This is in Pokhara at Davis Falls. (794k) | A Shiva Lingam next to the Indreshwor Mahadev temple in Panauti. (584k) | Shiva Lingam in the Shiva temple in Dhulikhel. (562k) | Large Shiva Lingam in Panauti. (560k) | A Shiva Lingam near the Bangalamukhi Temple in Patan. (489k) |
Very elaborate Shiva Lingam in the temple on the way to Nagarkot. (546k) | Elaborately decorated Shiva Lingam near the Shiva temple on the way to Nagarkot. (935k) | Shiva Lingam Statue from the Chăm Kingdom in the Chăm museum in Đà Nẵng in Việt Nam. (315k) | Shiva Lingams in a stream in Cambodia. (329k) | Shiva Lingam in a temple in Polonnaruwa in Sri Lanka. (591k) |
Nandi, Shiva's vehicle, the bull, in front of the Shiva temple near Nagarkot. (507k) | Statue of Nandi, the bull, vehicle of Shiva in Patan. It is protected in a cage. Apparently, art theft is a big problem in Nepal. (739k) | Nandi, the bull, the vehicle of Shiva in front of a Shiva temple in Patan. (563k) | Nandi, the bull, Shiva's mount, in front of the Yaksheshvara Temple in Bhaktapur Durbar Square. (598k) | Roof decoration on the Yaksheshvara Temple in Bhaktapur Durbar Square, showing Shiva's Trishula, the trident. (341k) |
Shiva's Trishula, the Trident at the Dattatraya Temple in Bhaktapur. (430k) | A statue near Nagarkot, showing Shiva's Trishula (trident, on right) and the Damaru (drum, on left). He also holds Vishnu's Shanka (conch shell, on right) and Chakra (spinning disk, on left). (618k) | Painting of Shiva, showing the Trishula (trident) and the Damaru (drum) on the right. He has the cobras around his neck, the third eye on the forehead, and the Candraśekhara, the crescent moon on his head. He has long, matted hair, with the Ganges river flowing from his matted hair. On his raised hand is a lingam. (589k) | Shiva statue showing the Trishula (trident) and the Damaru (drum), the cobras around the neck, and the Candraśekhara, the crescent moon on his head. (480k) |


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Best Ever Meatloaf
A recipe my mother used to make all the time. She got this recipe from a church cookbook and it is still a staple in my household. Very tasty
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Marybeth's Meatloaf Recipe
garlic, +beef, +steak sauce, +horseradish, +mustard, +worcestershire sauce, +onions, +bread crumbs, +eggs, +black pepper
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Best Sandwich Meatloaf Recipe
Here's a recipe I use for traditional meat loaf. The ingredient that makes this meat loaf extra delicious is the spicy ground pork sausage. There are a...
garlic, +bread crumbs, +carrot, +celery, +chili sauce, +eggs, +ketchup, +green onion, +sausage, +onions, +ground beef, +brown sugar, +butter, +mustard powder, +black pepper, +salt, +sauce
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Cheese and Mushroom-Stuffed Meatloaf
My family's favourite meatloaf (OK, sometimes my little one picks out the mushrooms). This one is really good.
garlic, +cheddar cheese, +sage, +thyme, +eggs, +bread crumbs, +ground beef, +ketchup, +olive oil, +onions, +parsley, +black pepper, +salt, +mushroom
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Savory Turkey Meatloaf Florentine
garlic, +turkey, +cereal, +eggs, +ketchup, +basil, +spinach, +red pepper, +onions, +dijon mustard, +honey
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Slow-cooker Meatloaf With Shiitake Mushrooms Recipe
Because no evaporation takes place, the crockpot makes an especially moist and tender meatloaf. The mushrooms add moisture as well. Taken from Cooking...
garlic, +onions, +shiitake mushroom, +eggs, +red pepper flakes, +ketchup, +dijon mustard, +italian seasoning, +salt
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Last Build Date: Tue, 29 Mar 2016 16:33:42 +0100
Sat, 19 Mar 2016 00:00:00 +0100
Publication date: Available online 19 March 2016 Source:Acta Haematologica Polonica Author(s): Anna Klukowska Patients with haemophilia are treated with a variety of coagulation factor concentrates. They usually change concentrate types many times during their lifetime for different, often independent, reasons. Since recombinant coagulation factor concentrates VIII and IX became available, some patients in well-developed countries have started using these products instead of previously applied plasma-derived concentrates. At the moment, there are different types of concentrates available, including first, second and third generation recombinant concentrates, and factor VIII concentrates with full length or B deleted domain molecule. The drug's efficacy and safety are both taken into con...MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Fri, 18 Mar 2016 23:15:02 +0100
Authors: Iida T, Satoh S, Nakagaki S, Shimizu H, Kaneto H Abstract A 50-year-old man was admitted to our hospital for an adhesive ileus 14 years after total abdominal colectomy for ulcerative colitis (UC). The ileus decreased with conservative treatment, however, autoimmune hemolytic anemia (AIHA) was diagnosed due to worsening anemia, a positive direct Coombs test, low haptoglobin, high lactase dehydrogenase, reticulocytosis, and an increase in the erythroblastic series in a bone-marrow examination. Human parvovirus B19 (PV-B19) IgM and PV-B19 DNA were present, indicating the development of AIHA triggered by an infection with PV-B19. The patient is currently being monitored after spontaneous remission. This is the first report of UC after total abdominal colectomy complicated by A...Thu, 17 Mar 2016 00:00:00 +0100
Human parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblasts in the bone marrow. B19 infection commonly causes erythema infectiosum, arthralgia, fetal death, transient aplastic crisis in patients with shortened red cell survival, and persistent infection in people who are immunocompromised. Less common clinical manifestations include atypical skin rashes, neurological syndromes, cardiac syndromes, and various cytopenias. B19 infection has also been associated with development of a variety of different autoimmune diseases, including rheumatological, neurological, neuromuscular, cardiovascular, haematological, nephrological and metabolic. Production of a variety of autoantibodies has been demonstrated to occur during B19 infection and these have been sho...Tue, 08 Mar 2016 00:00:00 +0100
This article reviews the modes of transmission as well as maternal and neonatal effects of each of these infections. In addition, the article outlines recommended testing, fetal surveillance, and treatment where indicated. (Source: Clinics in Laboratory Medicine)Wed, 24 Feb 2016 00:00:00 +0100
Parvovirus B19 (B19V) is known as the human pathogen causing the mild childhood disease erythema infectiosum. B19V shows an extraordinary narrow tissue tropism for erythroid progenitor cells in the bone marrow, which is determined by a highly restricted uptake. We have previously shown that the specific internalization is mediated by the interaction of the viral protein 1 unique region (VP1u) with a yet unknown cellular receptor. To locate the receptor-binding domain (RBD) within the VP1u, we analyzed the effect of truncations and mutations on the internalization capacity of the recombinant protein into UT7/Epo cells. Here we report that the N-terminal amino acids 5–80 of the VP1u are necessary and sufficient for cellular binding and internalization; thus, this N-terminal region represen...Fri, 19 Feb 2016 01:11:02 +0100
Authors: Anbarlou A, AkhavanRahnama M, Atashi A, Soleimani M, Arefian E, Gallinella G Abstract Human Parvovirus B19 (PVB19) is one of the most important pathogens that targets erythroid lineage. Many factors were mentioned for restriction to erythroid progenitor cells (EPCs). Previous studies showed that in non-permissive cells VP1 and VP2 (structural proteins) mRNAs were detected but could not translate to proteins. A bioinformatics study showed that this inhibition might be due to specific microRNAs (miRNAs) present in non-permissive cells but not in permissive EPCs. To confirm the hypothesis, we evaluated the effect of miRNAs on VP expression. CD34(+) HSCs were separated from cord blood. Then, CD34(+) cells were treated with differentiation medium to obtain CD36(+) EPCs. To eval...MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Tue, 16 Feb 2016 00:00:00 +0100
Authors: Jiménez-Rodríguez T, Romero-Pérez D, Andreu M, Ramos-Rincón JM PMID: 26888340 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)Tue, 16 Feb 2016 00:00:00 +0100
ConclusionWe suggest that COL4A1 testing should be considered in patients with schizencephaly as well as with phenotype suggesting TORCH infection without any proven etiological factors. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)Wed, 10 Feb 2016 00:00:00 +0100
In this study, we investigated virological and hematological findings, and also the clinical outcome, of seven cases of HIV/B19 coinfection (confirmed by PCR) after one year. These cases were provided from a previous study on patients with HIV infection that found B19 DNA in 13 cases. Seven of these 13 patients were available after 1 year, and we retested them for B19 viremia and B19-specific antibodies. B19 IgG was tested by ELISA, and B19 DNA was assessed by nested PCR. Anemia was not observed in these cases. All subjects had cleared viremia, but B19 IgG seroconversion occurred in two cases. No significant changes in CD4 and hemoglobin occurred. The results of this study indicate that B19 infection in HIV patients is a subtle infection and that B19 viremia is not a long-term event. (Sour...Thu, 04 Feb 2016 21:04:03 +0100
Conclusions: High prevalence of a viral genome in the myocardium of patients with DCM did not have an influence on their long-term clinical outcome.Intervirology 2015;58:350-356 (Source: Intervirology)Tue, 02 Feb 2016 00:00:00 +0100
Authors: Marco H, Guermah I, Matas L, Hernández A, Navarro M, Lopez D, Bonet J Abstract A previously healthy 32-yearold woman developed arterial hypertension, proteinuria, and hematuria (nephritic syndrome) with normal renal function and was diagnosed with post-infectious glomerulonephritis secondary to parvovirus B19 infection. The renal biopsy showed endocapillary glomerulonephritis, with positive IgG, C3, and C1q immunoreactivity in the capillary walls and ultrastructural evidence of subendothelial deposits. The diagnosis of parvovirus B19 infection was confirmed by IgG/IgM serological positivity and parvovirus DNA demonstration in both peripheral blood and kidney tissue. Glomerular involvement improved spontaneously. To be noted are the atypical signs and symptoms of our patie...MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Mon, 01 Feb 2016 00:00:00 +0100
Authors: Park J, Jeong DC, Yoo J, Jang W, Chae H, Kim J, Kwon A, Choi H, Lee JW, Chung NG, Kim M, Kim Y Abstract The aim of the present study was to describe the mutational characteristics in Korean hereditary spherocytosis(HS) patients. Relevant literatures including genetically confirmed cases with well-documented clinical summaries and relevant information was also reviewed to investigate the mutational gene- or domain-specific laboratory and clinical association. Twenty-five HS patients carried one heterozygous mutation of ANK1(n=13) or SPTB(n=12) but not in SPTA1, SLC4A1, or EPB42. Deleterious mutations including frameshift, nonsense, and splice site mutations were identified in 91%(21/23) and non-hotspot mutations were dispersed across multiple exons. Genotype-phenotype corre...Sun, 31 Jan 2016 00:00:00 +0100
Publication date: Available online 29 January 2016 Source:American Journal of Infection Control Author(s): Reynaldo Lara-Medrano, Michel Fernando Martínez-Reséndez, Elvira Garza-González, Ana Gabriela Medina-Torres, Adrián Camacho-Ortiz A human parvovirus B19 outbreak was detected in personnel assigned to a surgical area (anesthesiology fellows and an otorhinolaryngology fellow) in a university hospital. The attack rate between susceptible members was higher than previous reports. Diagnosis was determined by polymerase chain reaction for human parvovirus B19 in serum of 1 subject and immunoglobulin M/immunoglobulin G antibody titer in the remaining subjects. Medical personnel were put on leave of absence until resolution of symptoms and laboratory confirmation of health. No case...Thu, 28 Jan 2016 00:00:00 +0100
The present study aimed to determine the role of human parvovirus ?19 (B19V) as an aetiological agent in measles and rubella negative fever/rash patients from Bulgaria between 2004 and 2013. A total of 1,266 sera from all over the country were tested for B19V IgM antibodies and all positives were further investigated by polymerase chain reaction (PCR). Overall, 280 sera (22%) were B19V IgM positive and 227 of these (81%) were also PCR positive. The highest number of IgM positives was found among five to nine year-old children (27%). Eight infected women gave birth to healthy children; one fetus was aborted with hydrops fetalis. Of the 55 genetic sequences obtained, 54 belonged to genotype 1a and one grouped as a genotype 2 outlier. Phylogenetic analysis of all available genotype 2 sequence...Thu, 28 Jan 2016 00:00:00 +0100
Authors: Ivanova SK, Mihneva ZG, Toshev AK, Kovaleva VP, Andonova LG, Muller CP, Hübschen JM Abstract The present study aimed to determine the role of human parvovirus В19 (B19V) as an aetiological agent in measles and rubella negative fever/rash patients from Bulgaria between 2004 and 2013. A total of 1,266 sera from all over the country were tested for B19V IgM antibodies and all positives were further investigated by polymerase chain reaction (PCR). Overall, 280 sera (22%) were B19V IgM positive and 227 of these (81%) were also PCR positive. The highest number of IgM positives was found among five to nine year-old children (27%). Eight infected women gave birth to healthy children; one fetus was aborted with hydrops fetalis. Of the 55 genetic sequences obtained, 54 belonged to...Sat, 23 Jan 2016 18:57:02 +0100
Authors: Kechaou I, Cherif E, Boukhris I, Azzabi S, Kaouech Z PMID: 26791960 [PubMed - as supplied by publisher] (Source: Medecine et Maladies Infectieuses)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Wed, 20 Jan 2016 05:26:03 +0100
CONCLUSION: SSc is associated with a higher rate of certain infections, which deserves further investigation in order to assess the role of infections in disease etiology/pathogenesis. PMID: 26775370 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)Wed, 20 Jan 2016 00:00:00 +0100
Conclusions PVB19 can cause a devastating myocarditis in children. Children with fulminant myocarditis, ST segment changes or a short prodrome have the worst outcome. Transplantation may be considered, but is rarely required in the acute period if mechanical circulatory support is utilised. If the initial presentation is survived, recovery of the myocardium can occur even in those who had fulminant myocarditis. (Source: Archives of Disease in Childhood)Wed, 13 Jan 2016 12:15:09 +0100
This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)Wed, 13 Jan 2016 00:00:00 +0100
Publication date: Available online 12 January 2016 Source:Sensing and Bio-Sensing Research Author(s): M. Zangheri, M. Mirasoli, A. Nascetti, D. Caputo, F. Bonvicini, G. Gallinella, G. de Cesare, A. Roda Portable and simple analytical devices based on microfluidics with chemiluminescence detection are particularly attractive for point-of-care applications, offering high detectability and specificity in a simple and miniaturized analytical format. Particularly relevant for infectious disease diagnosis is the ability to sensitively and specifically detect target nucleic acid sequences in biological fluids. To reach the goal of real-life applications for such devices, however, several technological challenges related to full device integration are still to be solved, one key aspect r...Tue, 12 Jan 2016 20:15:40 +0100
No abstract available (Source: The Pediatric Infectious Disease Journal)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Tue, 12 Jan 2016 20:15:40 +0100
No abstract available (Source: The Pediatric Infectious Disease Journal)Wed, 06 Jan 2016 00:00:00 +0100
Human parvovirus B19 (B19V) infection causes a number of diseases in humans, and, in some circumstances, can be life threatening. To understand the epidemiology of B19V infection in the greater metropolitan area of Hangzhou, East China, we performed surveys of IgM and IgG antibodies against B19V and quantification of B19V DNA, by using enzyme‐linked immunosorbent assay and quantitative PCR, respectively, in plasma samples from diverse groups. These groups included anemia patients, Mycoplasma pneumonia‐ and Treponema pallidum‐infected patients, HIV‐positive individuals, and healthy blood donor volunteers. Our results demonstrated a low level of B19V IgG antibody presence, ranging from 21.9% to 41.8% in all the groups tested, suggesting a low prevalence of B19V infection in the area....Wed, 06 Jan 2016 00:00:00 +0100
ConclusionsInfectious disease screening does not seem beneficial in pregnancies with isolated polyhydramnios (Source: Prenatal Diagnosis)Tue, 05 Jan 2016 00:00:00 +0100
Authors: Servant-Delmas A, Morinet F Abstract Since its discovery, the human parvovirus B19 (B19V) has been associated with many clinical situations in addition to the prototype clinical manifestations, i.e. erythema infectiosum and erythroblastopenia crisis. The clinical significance of the viral B19V DNA persistence in sera after acute infection remains largely unknown. Such data may constitute a new clinical entity and is discussed in this manuscript. In 2002, despite the genetic diversity among B19V viruses has been reported to be very low, the description of markedly distinct sequences showed a new organization into three genotypes. The most recent common ancestor for B19V genotypes was estimated at early 1800s. B19V replication is enhanced by hypoxia and this might to explain...Fri, 01 Jan 2016 06:00:00 +0100
No abstract available (Source: Journal of Pediatric Hematology Oncology)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Fri, 01 Jan 2016 00:00:00 +0100
We report a 17-month-old boy with GS type 2 who presented with severe anemia. Bone marrow examination of the child suggested parvovirus B19 as the cause of severe anemia, which was later confirmed by DNA polymerase chain reaction. PMID: 26960654 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)Mon, 28 Dec 2015 00:00:00 +0100
In 1984, 2 pediatric neurologists, Jean Aicardi and Françoise Goutières, published their seminal case report of 8 patients (from 5 families) with a devastating neonatal encephalopathy characterized by striking cerebral calcifications, white matter hypodensities, visualized on CT, accompanied by a persistent CSF lymphocytosis.1 Notably, the neuroradiologic findings suggested a perinatal toxoplasmosis, other (syphilis, varicella-zoster, parvovirus b19), rubella, cytomegalovirus, and herpes (TORCH) infection, and these patients often have an elevation of interferon-α in the CSF.2,3 Three decades of highly productive clinical and scientific investigation of Aicardi-Goutières syndrome (AGS) has led to the discovery of 7 causative genes and the realization that mutatio...Thu, 24 Dec 2015 00:00:00 +0100
This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)Mon, 21 Dec 2015 03:45:46 +0100
CONCLUSION: There is demonstrated the temporal association of PVB19 viremia and collapsing FSGS, due primary infection or viral reactivation. The association of collapsing FSGS and PVB19 is described in the literature, demonstrating virus presence in kidney tissue, but the real relationship of virus in the pathogenesis of this glomerulopathy remains unclear. PMID: 25923759 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)Fri, 18 Dec 2015 00:00:00 +0100
CONCLUSIONS: We report an extremely rare presentation of non-febrile seizure from acute parvovirus infection in a child without encephalopathy who had an excellent recovery. Timely diagnosis can provide counselling regarding future seizure recurrence risk, curtail expenditure from expensive diagnostic work up and provide additional recommendations about potential risks to a pregnant caregiver. PMID: 26684306 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Tue, 15 Dec 2015 18:12:02 +0100
CONCLUSIONS: The survival rate for parvovirus infection associated with fetal hydrops was 60%. MCA-PSV and IUT are useful for the management and treatment of fetal anemia due to parvovirus infection. PMID: 25313841 [PubMed - indexed for MEDLINE] (Source: Fetal and Pediatric Pathology)Sat, 12 Dec 2015 19:19:29 +0100
We describe an unusual paediatric case of B19V associated with generalized petechial eruption, and a review of the recent literature. PMID: 25269970 [PubMed - in process] (Source: Infezioni in Medicina)Sat, 12 Dec 2015 19:19:29 +0100
Authors: Drago F, Ciccarese G, Javor S, Cozzani E, Parodi A Abstract No abstract available. PMID: 26397302 [PubMed - as supplied by publisher] (Source: Infezioni in Medicina)Thu, 10 Dec 2015 00:00:00 +0100
In this study we evaluated the performance of a commercially available and standardised CMV PCR assay in whole blood for the diagnosis of a primary infection in immunocompetent adults. Moreover, the kinetics of viral DNA was evaluated in order to provide a time frame in which viral DNA could be detected during an acute primary infection. Whole blood samples were collected from 66 patients with an acute CMV infection, 65 patients with an acute Epstein-Barr virus infection, 27 patients with various other acute infections (parvovirus B19, HIV, Toxoplasma gondii), 20 patients with past CMV infections (>1 year) and 20 apparently healthy persons. For CMV DNA detection and quantification a commercially available real-time PCR was applied (RealStar®, altona Diagnostics). The clinical sensitiv...Tue, 08 Dec 2015 00:00:00 +0100
(Source: Vox Sanguinis)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Wed, 02 Dec 2015 00:00:00 +0100
In this report, we present our experiences of successful treatment of a renal transplant case of TMA due to BK virus, not a frequent cause of TMA. The clinical picture of TMA caused by endothelial damage through cytopathic effects of viral antigens was evaluated in the light of the relevant literature. (Source: Indian Journal of Transplantation)Mon, 30 Nov 2015 02:50:19 +0100
Authors: Ramdass P, Mullick S, Farber HF Abstract In the vast world of skin diseases, viral skin disorders account for a significant percentage. Most viral skin diseases present with an exanthem (skin rash) and, oftentimes, an accompanying enanthem (lesions involving the mucosal membrane). In this article, the various viral skin diseases are explored, including viral childhood exanthems (measles, rubella, erythema infectiosum, and roseola), herpes viruses (herpes simplex virus, varicella zoster virus, Kaposi sarcoma herpes virus, viral zoonotic infections [orf, monkeypox, ebola, smallpox]), and several other viral skin diseases, such as human papilloma virus, hand, foot, and mouth disease, molluscum contagiosum, and Gianotti-Crosti syndrome. PMID: 26612372 [PubMed - in process...Mon, 30 Nov 2015 00:00:00 +0100
CONCLUSIONS Further research is required to clarify whether certain infections do increase miscarriage risk and whether screening of newly pregnant women for treatable infections would improve reproductive outcomes. (Source: Human Reproduction Update)Wed, 25 Nov 2015 03:18:43 +0100
In the vast world of skin diseases, viral skin disorders account for a significant percentage. Most viral skin diseases present with an exanthem (skin rash) and, oftentimes, an accompanying enanthem (lesions involving the mucosal membrane). In this article, the various viral skin diseases are explored, including viral childhood exanthems (measles, rubella, erythema infectiosum, and roseola), herpes viruses (herpes simplex virus, varicella zoster virus, Kaposi sarcoma herpes virus, viral zoonotic infections [orf, monkeypox, ebola, smallpox]), and several other viral skin diseases, such as human papilloma virus, hand, foot, and mouth disease, molluscum contagiosum, and Gianotti-Crosti syndrome. (Source: Primary Care: Clinics in Office Practice)Tue, 24 Nov 2015 00:00:00 +0100
Conclusion B19V IgG seropositivity was 49.7% among the study group. These patients exhibited lower hemoglobin levels and a significant association was found between B19V IgG seropositivity and hemoglobin level. (Source: International Journal of Gynecology and Obstetrics)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Fri, 20 Nov 2015 15:28:39 +0100
CONCLUSIONS: In our study, prevalence of IgG antibodies to PB19 was significantly higher in schizophrenic patients than in controls. This finding supports the hypothesis of the involvement of PB19 in schizophrenia. Further studies including both virological and immunological aspects are needed to better clarify the etiopathogenic mechanisms of schizophrenia which would challenge the management of this disease. PMID: 25529557 [PubMed - as supplied by publisher] (Source: L Encephale)Fri, 13 Nov 2015 00:00:00 +0100
In this study, we investigated the prevalence of antibodies against nine viral species found in umbilical cord blood obtained from 561 neonates in 2013. Serum IgG antibodies against the following viruses were measured: herpes simplex virus (HSV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), measles virus (MV), rubella virus (RV), mumps virus (MuV), and human parvovirus B19 (HPV B19). A survey questionnaire for past history and maternal immunization status was simultaneously administered for the vaccine-preventable diseases of varicella, measles, rubella, and mumps. The results were compared with previous data collected in 2001-2002 from 378 umbilical cord blood samples. Virus seroprevalence data were as follows: HSV, 54%; VZV, ...Fri, 13 Nov 2015 00:00:00 +0100
Human Parvovirus B19 (B19V) is a prototype of the Erythroparvovirus genus in Parvoviridae family. B19V infections are often associated with fever and rash, and can be mistakenly reported as measles or rubella. Differential diagnosis of B19V illness is necessary for case management and also for public health control activities, particularly in outbreak situations in which measles or rubella is suspected. To investigate the causative role of B19V infection in children with measles‐ and rubella‐like illness, a total of 583 sera from children with exanthema were tested for presence of B19V by determining anti‐B19V IgG and IgM antibodies by ELISA as well as B19V DNA detection by nested PCR. DNA positive samples were assessed further for determination of viral load and sequence analysis by...Thu, 05 Nov 2015 00:00:00 +0100
This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Thu, 05 Nov 2015 00:00:00 +0100
Conclusion Due to the allocation patterns of fluid filled sites in fetuses with hydrops fetalis the spectrum of possible etiologies may be narrowed already during initial ultrasound scan. It can contribute substantially to diagnostic accuracy as well as to parental counseling. This knowledge may also help to omit delay in diagnostic routines. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)Mon, 26 Oct 2015 00:00:00 +0100
Abstract Specific viruses are associated with pediatric myocarditis, but the prevalence of viral DNAemia detected by blood polymerase chain reaction (PCR) is unknown. We evaluated the prevalence of known cardiotropic viruses (enterovirus, adenovirus, human herpesvirus 6, and parvovirus B19) in children with clinical myocarditis (n = 21). Results were compared to pediatric controls with similar viral PCR testing. The majority of positive PCR (89 %) was noted in children ≤12 months of age at diagnosis compared to older children. Infant myocarditis patients (8/10) had increased the prevalence of PCR positivity compared to infant pediatric controls (4/114) (p < 0.0001). Other than age, patient characteristics at diagnosis were similar between PCR-positive and PCR-negative ...Mon, 19 Oct 2015 00:00:00 +0100
The objective of this study was to examine the B19V DNA prevalence and viral load in first-time volunteer blood donors. Blood samples were collected from 91 primary blood donors at the Regional Blood Center of Ribeirão Preto, Southeast Brazil. Viral detection and quantitation was performed by an in-house TaqMan® real-time PCR with high sensitivity. B19V DNA was detected in one male blood donor (1.0 %) and was characterized by a very low viral load (537.36 copies/mL). Our studies demonstrate that B19V DNA at low titer may be present in apparently healthy individuals. Sensitive molecular diagnostic tools can be applied for the screening of fresh blood derived products in order to prevent transfusion-transmitted B19V infection. (Source: Indian Journal of Hematology and Blood Transfusion)Mon, 12 Oct 2015 00:00:00 +0100
(Source: British Journal of Haematology)Thu, 08 Oct 2015 00:00:00 +0100
A 7-month-old infant presented with acute hemolytic anemia characterized by severe pallor, hepatosplenomegaly, hemoglobin 4.6g/dl, total bilirubin 4.02mg/dl (unconjugated 2.29), positive direct Coombs' test. The child received erythrocytes transfusion and therapy with high-dose of steroids, first intravenously and then orally. Laboratory showed also: AST 1088 U/l, ALT 1176 U/l, GGT 155 U/l, conjugated bilirubin 1.83mg/dl, LDH 2429 U/l, INR 1. Serological tests for HAV, HBV, HCV, EBV, CMV, HSV, Parvovirus B19, HIV were negative. (Source: Digestive and Liver Disease)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Thu, 08 Oct 2015 00:00:00 +0100
We report on a 3‐year‐old girl with a microvesicular generalized rash in whom primary infection by parvovirus B19 was demonstrated by seroconversion. To our knowledge, this is the first instance of an eruption arising from parvovirus B19 with this peculiar clinical pattern. (Source: Pediatric Dermatology)Tue, 06 Oct 2015 00:00:00 +0100
Conclusions: The high level of B19V in plasma pools could present a great risk in plasma derivatives. Therefore, the implementation of B19V NAT (Nucleic Acid Testing) assays capable of detecting all B19V genotypes and discard donations with high titer B19V DNA for Chinese blood products manufacturers seems to be necessary. (Source: Virology Journal)Fri, 02 Oct 2015 05:46:02 +0100
We describe 2 cases of 6-year-old twin girls presenting with acute carpal tunnel syndrome (CTS) associated with human parvovirus B19 (HPV-B19) infection, as evidenced by serological data and detection of HPV-B19 DNA in blood with use of polymerase chain reaction (PCR). To our knowledge, this is the first time that HPV-B19 infection has been suggested as the causal agent of simultaneous acute bilateral CTS in twins, thus presenting the possibility that similar immunologic responses can be observed in twins during viral infections. PMID: 26422355 [PubMed - in process] (Source: Acta Orthopaedica et Traumatologica Turcica)Thu, 24 Sep 2015 00:00:00 +0100
(Source: Blood)Thu, 24 Sep 2015 00:00:00 +0100
Autoimmunity results from immunization of an organism against its own constituents, leading to the production of autoantibodies and/or autoreactive cytotoxic cells. B lymphocytes and/or other cells responsible for autoimmunity are present in all healthy subjects, but are maintained inactive by a number of regulatory and control mechanisms. When this balance is disrupted, all subjects are able to develop an autoimmune disease. Three conditions are required to disrupt this balance, allowing the development of an autoimmune disease: multiple triggering factors (aetiology), persistence of their effects (pathophysiology), and induction of lesions (pathogenesis) [1]. (Source: Journal of Clinical Virology)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Fri, 18 Sep 2015 20:04:50 +0100
In a patient with sickle cell disease receiving chronic transfusion, exacerbation of anemia with reticulocytopenia must prompt consideration of a delayed hemolytic transfusion reaction with hyperhemolysis, as further transfusion may worsen this condition; definitive diagnosis is sometimes difficult. Anemia evolving during parvovirus B19-induced erythroid hypoplasia (transient aplastic crisis) should be attenuated in chronic transfusion patients due to superior survival of transfused over endogenous red blood cells. A 16-year-old with sickle cell disease receiving chronic transfusion of modified intensity (goal to maintain hemoglobin S (Source: Journal of Pediatric Hematology Oncology)Thu, 10 Sep 2015 00:00:00 +0100
Ectopic lymphoid follicle infiltration is a key event in Hashimoto's thyroiditis (HT). Positive regulatory domain zinc finger protein 1 (PRDM1), which induced by antigen stimulation, can regulate all lymphocyte lineages. Several groups independently demonstrated that human parvovirus B19 (PVB19) is closely associated with HT. Hence, we determined whether PRDM1 expressed in HT thyroid tissue and whether there is any correlation between PRDM1 expression and PVB19 in the pathogenesis of HT. We detected PRDM1 expression in HT (n=86), normal thyroid tissues (n=30), and non-toxic nodular goiter (n=20) samples using immunohistochemistry. (Source: Human Pathology)Thu, 10 Sep 2015 00:00:00 +0100
Ectopic lymphoid follicle infiltration is a key event in Hashimoto thyroiditis (HT). Positive regulatory domain zinc finger protein 1 (PRDM1), which is induced by antigen stimulation, can regulate all lymphocyte lineages. Several groups independently demonstrated that human parvovirus B19 (PVB19) is closely associated with HT. Hence, we determined whether PRDM1 is expressed in HT thyroid tissue and whether there is any correlation between PRDM1 expression and PVB19 in the pathogenesis of HT. We detected PRDM1 expression in HT (n = 86), normal thyroid tissue (n = 30), and nontoxic nodular goiter (n = 20) samples using immunohistochemistry. (Source: Human Pathology)Wed, 09 Sep 2015 00:00:00 +0100
CONCLUSION: The dual-target B19V polymerase chain reaction (PCR) showed good accuracy (<0.1 log IU/mL) at the crucial concentration of 10 IU/µL for the NS1 and the VP2 region of the B19V genome and detected all known genotypes with similar sensitivity for each genotype. In addition, the dual target format reduces the chance that molecular variants of B19V are wrongly quantified. The HAV RNA assay showed high sensitivity for Genotypes I to III. Both new PCR assays have been successfully introduced for plasma screening in test pools of 480 or 96 donations. PMID: 26354230 [PubMed - as supplied by publisher] (Source: Transfusion)Thu, 03 Sep 2015 00:00:00 +0100
Human parvovirus B19 (B19V) is a common pathogen in microvascular disease and cardiomyopathy, owing to infection of endothelial cells. B19V replication, however, is almost restricted to erythroid progenitor cells (ErPCs). Endothelial regeneration attributable to bone marrow–derived circulating angiogenic cells (CACs) is a prerequisite for organ function. Because of many similarities of ErPCs and CACs, we hypothesized that B19V is a perpetrator of impaired endogenous endothelial regeneration. B19V DNA and messenger RNA from endomyocardial biopsy specimens, bone marrow specimens, and circulating progenitor cells were quantified by polymerase chain reaction analysis. The highest B19V DNA concentrations were found in CD34+KDR+ cells from 17 patients with chronic B19V-associated cardiomyo...MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Tue, 01 Sep 2015 00:00:00 +0100
Authors: Conteville LC, Zanella L, Marín MA, Filippis AM, Nogueira RM, Vicente AC, Mendonça MC Abstract Parvovirus B19 (B19V) infects individuals worldwide and is associated with an ample range of pathologies and clinical manifestations. B19V is classified into three distinct genotypes, all identified in Brazil. Here, we report a complete sequence of a B19V genotype 1A that was obtained by high-throughput metagenomic sequencing. This genome provides information that will contribute to the studies on B19V epidemiology and evolution. PMID: 26517666 [PubMed - in process] (Source: Memorias do Instituto Oswaldo Cruz)Thu, 27 Aug 2015 00:00:00 +0100
We describe here the presentation, therapeutic management and outcome of 18 patients with non-HCV infectious CryoVas and 27 additional patients identified form a systematic review of the literature. We included 18 patients, mean age 57.9±13.5 years. Infectious causes were viral infections in 8 patients [hepatitis B virus (HBV) in 4, and cytomegalovirus, Epstein Barr virus, parvovirus B19 and human immunodeficiency virus in one case each], pyogenic bacterial infection in 6 patients, parasitic infection in 2 patients, and leprosy and candidiasis in one case each. Baseline manifestations were purpura (78%), glomerulonephritis (28%), arthralgia (28%), peripheral neuropathy (22%), skin necrosis (22%), cutaneous ulcers (17%), and myalgia (11%). Cryoglobulinemia was type II in 2/3 of cases. Most...Wed, 19 Aug 2015 00:00:00 +0100
This study suggests that CRP values are useful to define viral and atypical bacterial infections compared with normal values, but, it is not useful to define type of infection. J. Med. Virol. © 2015 Wiley Periodicals, Inc. (Source: Journal of Medical Virology)Fri, 14 Aug 2015 18:11:17 +0100
This case is presented to highlight that one of the causes for massive exudative pericardial effusion in a child may be parvovirus B19, and adenosine deaminase can be falsely positive in such patients. (Source: The Pediatric Infectious Disease Journal)Tue, 04 Aug 2015 00:00:00 +0100
This study suggests that CRP values are useful to define viral and atypical bacterial infections compared with normal values, but, it is not useful to define type of infection. This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Sat, 01 Aug 2015 00:00:00 +0100
Authors: Allmon A, Deane K, Martin KL Abstract Because childhood rashes may be difficult to differentiate by appearance alone, it is important to consider the entire clinical presentation to help make the appropriate diagnosis. Considerations include the appearance and location of the rash; the clinical course; and associated symptoms, such as pruritus or fever. A fever is likely to occur with roseola, erythema infectiosum (fifth disease), and scarlet fever. Pruritus sometimes occurs with atopic dermatitis, pityriasis rosea, erythema infectiosum, molluscum contagiosum, and tinea infection. The key feature of roseola is a rash presenting after resolution of a high fever, whereas the distinguishing features in pityriasis rosea are a herald patch and a bilateral and symmetric rash in ...Sat, 01 Aug 2015 00:00:00 +0100
ConclusionsThe transfer of RP to producing plasma derivatives will not increase the risk of transmission of HAV and B19 through plasma products. (Source: Transfusion Medicine)Wed, 29 Jul 2015 00:00:00 +0100
Authors: Manaresi E, Bua G, Bonvicini F, Gallinella G Abstract Human parvovirus B19 (B19V) replication is a process highly dependent on the cellular environment, therefore methodologies allowing for analysis at single cell level could represent effective tools to understand cell-to cell differences in the replication process and to investigate cell-virus interactions. Fluorescence in situ hybridization (FISH) can be combined with flow cytometry (flow-FISH) to enable the detection of target nucleic acid sequences in thousands of individual cells in a short amount of time. In the present study, a flow-FISH assay based on the use of a digoxigenin-labeled genomic probe has been developed to discriminate B19V infected cells following in vitro infection of UT7/EpoS1 cell line and EPCs (e...Fri, 03 Jul 2015 00:00:00 +0100
ConclusionsWe want to underline the importance for patients with RS3PE to be seen by dermatologists who should become familiar with this syndrome and remark that Parvovirus B19 infection may be a potential cause of RS3PE. (Source: International Journal of Dermatology)Thu, 02 Jul 2015 00:00:00 +0100
Conclusion The viral load of PVB19 genomes in the myocardium is not related to the long-term outcome. Furthermore, this study suggests a growing role of imaging for risk stratification in non-ischemic myocardial disease. (Source: Clinical Research in Cardiology)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Wed, 01 Jul 2015 00:00:00 +0100
Authors: Kishore J PMID: 26261172 [PubMed - in process] (Source: Indian J Med Res)Fri, 26 Jun 2015 00:00:00 +0100
Publication date: May–June 2015 Source:Pediatria Polska, Volume 90, Issue 3 Author(s): Joanna Krukowska-Jaros , Ewa Niedzielska , Marek Ussowicz , Hanna Gazda , Stanisław Zajączek , Ewa Gorczyńska Anaemia is one of the most common haematological problems in infants. Diagnosis of anaemia is based on anamnesis, the results of physical examination and basic laboratory tests. During infancy, one of the main causes of anaemia is iron deficiency but in some cases haematopoiesis can be hampered by myeloproliferative disease, congenital or acquired bone marrow failure, too. This paper presents a case report of a 6-month-old girl with typical dysmorphic features. Initially the girl was diagnosed with iron-deficiency anaemia, due to suspected chronic gastrointestinal bleeding, as a result of ...Tue, 09 Jun 2015 02:50:20 +0100
We describe here cases of diffuse, uniformly increased 18F-FDG activity due to nonmalignant illnesses in 2 patients: one had parvovirus B19 infection, whereas the other had porphyria, a heme synthesis disorder. (Source: Clinical Nuclear Medicine)Mon, 08 Jun 2015 00:00:00 +0100
Authors: Gabor JJ, Schwarz NG, Esen M, Kremsner PG, Grobusch MP Abstract Clinical and epidemiological data from Central Africa on influenza A and parvovirus B19 infections are limited. We analyzed 162 blood samples of infants 3, 9, 15, and 30 months of age for IgG antibodies against both pathogens. Antibody responses were 0, 3.7%, 12.3%, and 20.4% against influenza A; and 1.2%, 2.5%, 3.1%, and 9.3% against parvovirus B19, respectively. Seropositivity rates were 89.5 (95% confidence interval [CI]: 59-120.1) and 38.2 (95% CI: 18.9-57.6)/1,000 person-years at risk for influenza A and parvovirus B19, respectively. Our data add to the understanding of the epidemiology of both conditions. PMID: 26055747 [PubMed - as supplied by publisher] (Source: The American Journal of Tropical Med...Fri, 05 Jun 2015 00:00:00 +0100
ConclusionsTT‐B19V infections through blood components with low (<104 IU/ml plasma) B19V DNA concentrations did not occur in our study. One of the TT‐B19V infections occurred from RBC with intermediate B19V DNA concentration despite the presence of potential neutralizing antibodies in the donor, but its clinical significance was low. (Source: Vox Sanguinis)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Wed, 03 Jun 2015 16:15:43 +0100
Authors: Drwiła R, Rubiś P, Kapelak B, Rudnicka-Sosin L, Pankuweit S, Gackowski A PMID: 25666442 [PubMed - in process] (Source: Polskie Archiwum Medycyny Wewnetrznej)Tue, 02 Jun 2015 00:00:00 +0100
Conclusion: Contemporary management of Rhesus disease is associated with encouraging neonatal outcomes. In case of Parvovirus infection, no specific management is necessary at. But, in all cases of fetal anemia, children should be followed up with particular attention to neurologic development. What is Known: • In-utero transfusion is now well under control and improves the survival of fetuses monitored for fetal anemia. • Limited studies are available on the effect of IUT on postnatal outcome in infants with a history of fetal anemia. What is New: ...Mon, 01 Jun 2015 00:00:00 +0100
Authors: Subtil D, Garabedian C, Chauvet A Abstract "Small virus" contagious during spring, parvovirus B19 is responsible for fifth disease of children. The prevalence of infection is very high before 10years old and children are especially responsible for transmission to pregnant women. Approximately 50% of women old enough to procreate have stigmas serologic of old infection. Acquired immunity is long hasting and solid. During pregnancy, this virus is responsible for abortion, fetal anemia. Severe anemia can cause hydrops fetalis or fetal mortality in utero or neurologic damage. We are going to start again point by point of the contage has the care the situations with which the doctor can be confronted during the pregnancy. PMID: 26044725 [PubMed - as supplied by publisher] (...Thu, 28 May 2015 00:00:00 +0100
In conclusion, the array-in-well with upconverting phosphor reporter technology was able to detect antiviral antibodies in human sera, and represents an efficient serodiagnostic concept that is a promising new tool for multiplex serology. PMID: 26028427 [PubMed - as supplied by publisher] (Source: Journal of Virological Methods)Sun, 24 May 2015 15:34:09 +0100
Authors: PMID: 26000539 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Thu, 14 May 2015 00:00:00 +0100
The relationship between viral infections and first‐trimester spontaneous abortions is not well‐understood. The study aim was to investigate the prevalence of cytomegalovirus (CMV), human parvovirus B19 (B19V), and herpes simplex virus‐1/2 (HSV‐1/2) infection by molecular and serological techniques in women experiencing spontaneous miscarriage in the first trimester of pregnancy. Plasma samples were examined for CMV, B19V, and HSV‐1/2 DNA using real‐time quantitative polymerase chain reaction (Real‐time qPCR), and for specific IgG antibodies against B19V, CMV, and HSV‐1/2 using serological assays. The abortion group consisted of women (n = 1,716) with a history of two or more first‐trimester spontaneous abortions. Women younger than 30 years possess higher portion to ...Wed, 13 May 2015 05:19:39 +0100
A infecção pelo Parvovírus B19 costuma ser assintomática, mas as expressões clínicas podem incluir crise aplástica transitória, eritema infeccioso, hidropisia fetal não imune e aplasia crônica da série vermelha. Esse vírus também se associa à artrite reumatoide e a outras doenças autoimunes do tecido conjuntivo; entretanto, não conseguimos identificar na literatura nenhum caso de miosite aguda em adulto desenvolvida depois de infecção pelo Parvovírus B19. Por essa razão, gostaríamos de apresentar um caso raro de miosite aguda desenvolvida depois de infecção pelo Parvovírus B19. Nos pacientes que apresentam sintomas de febre, rash nas pernas e miosite, devem ser consideradas as infecções virais, como a causada pelo Parvovírus B19.Parvovirus B19 infection is often ...Tue, 12 May 2015 00:00:00 +0100
In conclusion this study reveals that atypical exanthems related to B19V infection are possible both in children and in adults, with a similar prevalence. J. Med. Virol. © 2015 Wiley Periodicals, Inc. (Source: Journal of Medical Virology)Fri, 08 May 2015 00:00:00 +0100
Publication date: May 2015 Source:Actas Dermo-Sifiliográficas (English Edition), Volume 106, Issue 4 Author(s): S. Sai Tin , V. Wiwanitkit (Source: Actas Dermo-Sifiliograficas)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Wed, 06 May 2015 00:00:00 +0100
Viral reactivations following hematopoietic stem cell transplantation are thought to result from the breakdown of both cell‐mediated and humoral immunity. As a result, many viruses could be reactivated individually or simultaneously. Using a multiplex polymerase chain reaction (PCR), we prospectively examined many kinds of viral DNAs at a time in 105 patients who underwent allogeneic hematopoietic stem cell transplantation. In total, 591 whole blood samples were collected weekly from pre‐ to 42 days post‐transplantation and the following 13 viruses were tested; herpes simplex virus 1 (HSV‐1), HSV‐2, varicella‐zoster virus (VZV), Epstein–Barr virus (EBV), cytomegalovirus (CMV), human herpes virus 6 (HHV‐6), HHV‐7, HHV‐8, adenovirus, BK virus (BKV), JC virus (JCV), parvov...Fri, 01 May 2015 00:00:00 +0100
SUMMARY Parvovirus B19 is a single‐stranded DNA virus which preferentially targets the erythroblast resulting in red cell aplasia, which is temporary in immunocompetent persons. Since the discovery of B19 virus in 1975, a wide variety of blood diseases and cytopenias affecting several blood cell lineages have been documented during or following B19 infection. These include cytopenias affecting the erythroid, megakaryoblastoid, myeloid and lymphoid lineages, as well as a variety of bicytopenias, pancytopenia, bone marrow necrosis / fat embolism syndrome, myelodysplastic syndrome, leucoerythroblastopenia, and hemophagocytic lymphohistiocytosis. B19 infection may also complicate and precede the course of acute leukemia, the significance of which remains to be determined. This review describ...Tue, 28 Apr 2015 00:00:00 +0100
Summary The virological diagnosis of Parvovirus B19 (PvB19) infection is currently based on sero‐diagnosis, molecular methods or both, yet without clear recommendations. We retrospectively identified patients with polymerase chain reaction‐positive PvB19 and/or positive serological assay between 2007 and 2013. Eighty‐two adults with at least one diagnostic criterion of recent PvB19 infection (IgM antibodies, viral DNA in blood and/or in marrow) were included and classified into three homogeneous groups: 30 patients had no underlying predisposing condition, 25 a hereditary haemolytic anaemia, 27 an underlying immunodeficiency. The classical PvB19‐related manifestations were less frequent in immunocompromised than in immunocompetent patients (arthromyalgia: 5 vs. 14; erythema: 4 vs....Fri, 24 Apr 2015 12:09:31 +0100
Conclusion: This study of B19V-DNA load and levels of neopterin, IgM, and IgG allows for reliable characterization and distribution into the different stages of B19V infection.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)Tue, 07 Apr 2015 00:00:00 +0100
(Source: Clinical Pediatrics)MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Tue, 07 Apr 2015 00:00:00 +0100
Publication date: Available online 6 April 2015 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): A.I. Rodríguez Bandera , M. Mayor Arenal , K. Vorlicka , E. Ruiz Bravo-Burguilllos , D. Montero Vega , C. Vidaurrázaga Díaz-Arcaya (Source: Actas Dermo-Sifiliograficas)Wed, 01 Apr 2015 00:00:00 +0100
We report on the long-term outcomes of 2 extremely preterm children after non-immune hydrops fetalis due to intrauterine B19V Infection. PMID: 25830498 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Geburtshilfe und Neonatologie)Tue, 17 Mar 2015 00:00:00 +0100
In this study, we present a new PCR assay for detection and quantification as well as for differentiation of all three B19V genotypes. A new B19V qPCR was designed to target a 154-bp region of the NS1 area. Serum, plasma and solid tissue samples were suitable for testing in the assay. The WHO International Reference Panel for Parvovirus B19 Genotypes was utilized to validate the assay for detection of different genotypes of B19V in clinical material. Each panel member yielded, by the new qPCR, a quantity similar to the one reported by National Institute for Biological Standards and Control (NIBSC). The qPCR was specific for B19V and amplified and quantified all three genotypes with detection sensitivities of ≤10 copies/reaction. The differentiation of B19V genotypes was performed by Sang...Sat, 14 Mar 2015 00:00:00 +0100
We report here the case of a 3-year-old girl who developed myocarditis secondary to parvovirus B19 virus. Diagnosis of PVB19 infection was made with serological tests. The outcome was favorable after immunoglobulins. (Source: Pediatric Infectious Disease)Fri, 13 Mar 2015 00:00:00 +0100
The human parvovirus B19 (B19) usually causes a subclinical infection in immunocompetent individuals. Whereas immunocompromised individuals such as patients infected with HIV are at risk of persistent anemia due to B19 infection. Only few studies have been carried out on distribution and molecular epidemiology of B19 in Iran. We aimed to determine the frequency and genotype of B19 among Iranian patients infected with HIV. We conducted a survey on 99 HIV patients and 64 healthy controls. IgG and IgM antibodies against B19 were detected by ELISA and B19 DNA was assessed by nested PCR. PCR products were subjected to direct sequencing and classified after phylogenetic analysis. The prevalence of B19 immunoglobulin was 11.1% for IgG and 1% for IgM. B19 DNA was detected in 13.1% of cases. The pr...MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
Thu, 12 Mar 2015 00:00:00 +0100
Conclusions Parvovirus B19 virus infection should be considered when a sudden exacerbation of anemia occurs in a patient with hemolytic disease, and the possible fetal complications caused by maternal B19 virus infection during pregnancy should not be ignored. Close monitoring and adequate management can keep both mother and fetus safe. (Source: Journal of Medical Case Reports)Sun, 08 Mar 2015 22:24:03 +0100
CONCLUSIONS: Using EFA and DAS28, a correlation between the clinical activity of RA and B19 infection was confirmed. These data suggest that EFA is applicable for medico-biological studies. PMID: 25744771 [PubMed - in process] (Source: Medicina (Kaunas))Sun, 01 Mar 2015 00:00:00 +0100
Summary In this article, we review the evidence suggesting a possible role for B19 virus in the pathogenesis of a subset of cases of acute leukemia. Human parvovirus B19 infection may complicate the clinical course of patients with acute leukemia and may also precede the development of acute leukemia by up to 180 days. Parvovirus B19 targets erythroblasts in the bone marrow and may cause aplastic crisis in patients with shortened‐red cell survival. Aplastic crisis represents a prodrome of acute lymphoblastic leukemia in 2% patients. There is a significant overlap between those HLA classes I and II alleles that are associated with a vigorous immune response and development of symptoms during B19 infection and those HLA alleles that predispose to development of acute leukemia. Acute symp...Fri, 20 Feb 2015 00:00:00 +0100
Infections caused by viruses are universal during childhood and adolescence. Clinicians will regularly care for children and adolescents who present with infections caused by a wide number of viral pathogens. These infections have varied presentations. Many infections may have clinical presentations that are specific to the infecting virus but present differently, based on the age and immunocompetence of the patient. Some children are directly impacted early in their lives when maternal disease results in an in utero infection (cytomegalovirus, rubella virus, or parvovirus B19). (Source: Current Problems in Pediatric and Adolescent Health Care)Thu, 19 Feb 2015 00:00:00 +0100
Authors: Santillán-Uribe JS, Valadez-García J, Morán-García AD, Santillán-Uribe HC, Bustos-Jaimes I Abstract Virus-like particles (VLPs) are valuable tools for nanotechnology and nanomedicine. These particles are obtained by the self-assembly, either in vivo or in vitro, of structural proteins of viral capsids. VLPs are excellent scaffolds for surface display of molecules. The N-termini of the structural proteins of human parvovirus B19 (B19V) have been already modified to display peptides or proteins. However, other surface-exposed elements have not been studied as potential locations for peptide display. In this research, we tested the potential of surface loop 62-75 of VP2 protein for the presentation of a 64-residue heterologous peptide. The chimeric protein was able to se...MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.


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Arlington, VA
Finding Apartments for Rent in Arlington, VA
Finding a place to rent in Arlington does not have to be a difficult endeavor. There are several unofficial neighborhoods that each create a slightly different feel, so that everyone can find the perfect residence for them. From historical single family homes to the artsy and urban portions of the city found near the business district, each neighborhood has something special.
The city offers plenty of culture, dining, activities, and more, making it an enjoyable place to live, right in the backyard of the nation's capital. The only question that those looking to live in the area should concern themselves with would be which neighborhood will be right for them.
Top Neighborhoods in Arlington, VA
Arlington is divided into several unofficial neighborhoods, each with a unique personality and benefits to offer. Ballston, for example, has its own metro station, which makes commuting and access Washington, D.C. exceptionally easy. It is also home to the Ballston Common Mall, a yearly food festival, exciting shopping and dining options, and several government offices for jobs.
Crystal City offers the uniqueness of being an almost entirely underground city, where residents can live, go shopping, and even go to work without going outside should they not want to. This especially helpful when inclement weather arrives. The area has been redesigned to capture a modern city feel and offers shopping, dining, job opportunities, and city access.
Those who prefer a more historical feel to their neighborhood will appreciate Aurora Highlands, which is a historical district where most of the homes and buildings are built in the Colonial Revival style. The landscaped parks, single family homes, churches, and commercial buildings give the area a welcoming feeling of a bit of suburbia in the city.
Rosslyn is good for those looking for a traditionally urban feel, where the skyscrapers and business sections of the city give the area a distinct feel. The area is right over the Potomac from Georgetown and offers a considerable number of opportunities for arts and culture, including annual film festivals.
Dining in Arlington, VA
As the second largest principal city in the Washington, D.C. metro area, Arlington offers a host of dining options for nearly any palette to enjoy. From casual sandwich shops and cafes to fine dining experiences, the area has just about everything that people could wish to treat themselves with.
Like elsewhere in the D.C. metro area, there are several excellent places to try some seafood in Arlington, with locals salivating over scallops and oysters at their favorite seafood joints. Those interested in trying a bit of ethnic food can branch out to any of the dozens of options available. This includes Ethiopian cuisine, Pakistani, Afghani, Lebanese, Turkish, French, Peruvian, Mexican, and more. Just about any style and flavor is represented in the diverse city of Arlington. There are also a number of delectable eateries featuring Italian food as well as steakhouses serving tender, moist steaks that are loved throughout the area.
Those interested in just enjoying a hearty sandwich or a meal on the go will not struggle to find a favorite bistro or sandwich shop, either. These locations are popular for lunch with the locals or just an outing with some friends.
Transportation Options in Arlington, VA
Given its close proximity to Washington, D.C., Arlington is included on the city's metro system on the Orange, Blue, and Yellow lines. Commuters also have the option of using the Virginia Railway Express commuter rail to bring them into the city. There are also several different public bus systems, including Metrobus, the Fairfax Connector, Potomac and Rappahannock Transportation Commission (PRTC), and the Arlington Transit bus system.
Those interested in making their transportation a bit greener, or just looking for some exercise, can also participate in the Capital Bikeshare, which as 14 rental locations throughout Arlington. The bikeshare allows people to check bikes in and out of rental locations and use them for commutes or just to get around the city.
Arlington also is well connected by highways, which makes it easy for residents to use their cars to move around the city or travel wherever they need to go.
Cultural Attractions in Arlington, VA
Arlington is home to a number of different cultural attractions. It is within walking distance of Georgetown, in Washington, D.C., which is a popular place for shopping, dining, and exploring. Within the city itself, there is also Arlington Cemetery and the Pentagon.
Arlington National Cemetery was established during the American Civil War on the grounds of Confederate General Robert E. Lee's home. It is the final resting place of about 330,000 members of the military and is the second largest national cemetery in the U.S. Graves on the land date back to the American Revolution and are as recent as deaths from the military actions in Afghanistan and Iraq. Those interested in visiting can see popular attractions such as the Tomb of the Unknown Soldier, the Eternal Flame over President John. F. Kennedy and his family, and the tomb of President William Howard Taft. Near the cemetery is also the U.S. Marine Corps War Memorial, the U.S. Air Force Memorial, and the Women in Military Service for America Memorial.
The Pentagon, which houses the U.S. Department of Defense, has about 23,000 military and civilian employees on five floors. It is known for being a remarkably efficient building, with people being able to get from one point of the building to another in about 7 minutes.


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Worried About Not Being Worried
I am beginning to worry about my own complacency. As a person who has been a participant in the fixed-income markets for a long time, I have become quite naturally a very cautious investor. Such caution is a quintessentially fixed-income mindset (although you might not guess that from the way bond people behaved in the run-up to the global financial crisis) - as a bond investor, you are essentially in the position of someone who is short options: taking in small amounts on a regular basis, with an occasional large loss when the credit defaults. A bond investor can greatly improve his performance in the long run relative to an index by merely avoiding the blow-ups. Miss the Enron moment, and you pick up a lot of relative performance. (The same is true of equities, but there is much more upside to being an optimist. The stock market selects for optimists, the bond market for pessimists.)
This is a lesson that many high-yield investors today, chasing near-term carry, seem to have forgotten. But my purpose here isn't to bash those involved in the global reach for yield. I am merely pointing out that this is how I tend to think. I am always looking for the next disaster that hangs a portfolio with a big negative number. As Prince Humperdinck said in The Princess Bride, "I always think everything could be a trap - which is why I'm still alive."
And I am starting to worry about my own complacency. I don't get the feeling that we're gearing up for Round 2 of the global financial crisis. Something bad, perhaps, but not catastrophic.
To be sure, there are a large number of potential pitfalls facing investors today, and I think market volatilities underestimate their probabilities substantially. We are facing an inflection in policy from the ECB this week, with analysts expecting a substantial additional easing action (and it is overdue, with money growth in Europe down to a feeble 1.9% y/y, near the worst levels of the post-crisis period - see chart, source Bloomberg). Absent a major change in policy, liquidity on the continent is going to become increasingly dear with possible ramifications for the real economy as well as the asset economy.
The Federal Reserve is facing a more-serious policy inflection point, with no agreement amongst FOMC members (as far as I can tell) about how to transition from the end of QE to the eventual tightening. I've pointed out before - while many Fed officials were whistling Dixie about how easy it would be to reverse policy - that there is no proven method for raising interest rates with the vast quantity of excess reserves sitting inert on bank balance sheets. Moreover, raising interest rates isn't the key...restraining money growth is. The key point for markets is simply that there is no plan in place that removes these reserves, which means that interest rates are not likely to respond to Fed desires to see them rise. And, if the Fed uses a brute-force method of raising the interest paid on excess reserves, then rates may rise but we don't know what will happen to the relative quantities of required and excess reserves (and it is the level of required reserves that actually matter for inflation). It is a thorny problem, and one which the markets aren't giving enough credit regarding the difficulty thereof.
Valuation levels are high across the board (with the exception of commodity indices). They're doubly high in stocks, with high multiples on earnings that are themselves high with respect to revenues. And yes, this concerns me. I expect more volatility ahead, and perhaps serious volatility. But the fact that I am just saying "perhaps," when all of my experience and models say "there is no escape without some bad stuff happening," means that I am being infected - relative to my usual caution - by the general complacency.
In other words, I am worried that I am not worried enough.
The interesting thing is that equity bulls said during the entire march higher that "it doesn't matter what the fundamentals are, the Fed is pushing the market higher and spreads tighter." I still don't believe that was an inevitable outcome to the Fed's QE, but the fact is that people believed it and they were correct: that was enough to keep the market going higher. I can't be comfortable going along with the crowd in that circumstance, but in retrospect it would have been better to abandon the models, throw caution to the wind, and ride along with the fun. And perhaps this regret is one reason for my developing complacency.
But that way lies madness, since the problem is not the ride but the getting out when the ride is over. The Fed is no longer providing QE (or, in any event, QE will shortly end altogether). So what's the excuse now? It seems to me that everyone is still riding on the fun train, and just watching carefully to see if anyone jumps off. I think the market rally is on very tenuous footing, because if faith in the market's liquidity goes away, the value anchor is very far from these levels. Yet, part of me is skeptical that a market which hasn't corrected in more than two years can actually return to those value anchors. I should know better, because the bond-market mindset reminds me that market gains are generally linear while market losses are discontinuous, sloppy, and non-linear. Especially, I ought to be thinking, when market liquidity is so poor thanks to the government's assault on market makers over the last few years.
I keep wondering if there is one more pulse higher in stocks coming, one more decline in commodities before they begin to catch up with money growth and inflation, one more rally in bonds before they begin to discount a higher inflation path. And this is very possible, because while I worry about my own developing complacency most investors are not concerned about their own.
Complacency or no, insurance is cheap. The low current level of implied volatilities in almost every asset class makes portfolio protection worthwhile, even if it costs a bit of performance to acquire that protection.
You can follow me @inflation_guy!
Enduring Investments is a registered investment adviser that specializes in solving inflation-related problems. Fill out the contact form at http://www.EnduringInvestments.com/contact and we will send you our latest Quarterly Inflation Outlook. And if you make sure to put your physical mailing address in the "comment" section of the contact form, we will also send you a copy of Michael Ashton's book "Maestro, My Ass!"


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The housework was finished quickly just so I could sit and stitch these darling little elephants. It was fun but much too soon finished. Now I have to wait a whole long month for another pair of animals.
Jul 7, 2008
Teeny Tiny Two-inch Elephants
Labels: Noah's Ark BOM, stitchery
7 comments:
- Stephanie said...
Too cute. This must be elephant day...Nanette at Freda's Hive posted about elephants too!
- July 7, 2008 at 2:25 PM
- Nanette Merrill and daughters said...
Oh I love them!! Like Stephanie said, I had elephants today and so did taffytalk.blogspot.com. They are so popular.
- July 7, 2008 at 3:32 PM
- Red Geranium Cottage said...
Oh how cute!!!
- July 7, 2008 at 8:45 PM
- The Quilt Buddy said...
Too cute! I am way far behind, but after seeing yours, I think that I will have to sit and stitch!
- July 8, 2008 at 1:44 AM
- MouseChirpy said...
Annette, your elephant stitcherie is just the cutest. Your quilt looks like it's taking shape pretty fast and I bet you'll have no problem meeting your goal to have it finished by September. Take care.
Aloha! - July 8, 2008 at 7:41 PM
- The Hodsons said...
Mine look almost as good as yours :)
- July 8, 2008 at 11:27 PM
- Jeanette said...
Great job on the elephants, I just started tonight and have my little bunnies all done YAY
I am however running into trouble doing the ark picture witht the link back to Lynette's blog, can you help me with that by any chance? - July 9, 2008 at 11:43 PM


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Above you can see a little rigging project I have going on. Tomorrow I begin assembling the constraints and binding the rig to the model's geometry. Right now, all you can see is the skeleton through the model. The model is a simplified cat (provided by my instructor, Liz Van Verth – Assistant Animation Director at Kansas City Art Institute). I'm thinking this cool cat needs a name…Mac! The name must be inspired by the device I've been staring into for the past few hours.
The complex table to the right is a portion of the breakdown of the rig. I'm actually REALLY enjoying this process. I'll be attempting to model and rig a model of project of my own outside of class. I've been wanting to work with dolphins in animation for the longest time. The edge flow doesn't look too complicated to model.
Monthly Archives: March 2012
HSU-NAMI ~ 2012 Taiwan Tour
If there's any band that's worth supporting, then hands down it's HSU-NAMI. There universally understood and powerful songs are truly unique, and they have plans to tour in Taiwan this year and put on an unforgettable show. They also have some great perks in place to thank you for your generosity. Times are tight, but if you can manage it they'd greatly appreciate it.
JULES ENGEL – Share His Story
Above is the link to a website that has been created by this incredible artist's biographer. She is launching a plan to generate funds to complete the documentary of Jules Engel's life & work.
For those who are unfamiliar with Jules Engel, his work ranges from: designing animation sequences for Disney's Fantasia (1940), founding UPA, and establishing the experimental animation program at CalARTS.
UPA is the animation studio responsible for many animation classics like "Gerald McBoing Boing", "The Unicorn In The Garden", and "Mr. Magoo".
My Favorite Thing In Maya – SUCCESS!
My biggest accomplishment in Maya, no doubt. This study is the first test of a project I'm titling "Rhythmatics"
The soundtrack is "Four Ways of Mystery" from the soundtrack of SEGA's "Ecco: Defender Of The Future" (©SEGA 2000)
You'll definitely want to crank the brightness on your display to get all the subtleties of this animation. You don't want to miss a thing.
After some struggles with character animation, I have fully rendered this short study.
So much sexy animation! It's a little rough towards the end, but not too shabby overall.
The Official Start Of A Grand Endeavor
I would consider the first actual day of production to have been around March 2, 2012. That was when I got confirmation from HSU-NAMI to not only have creative use of their music, but also received their approval to use this project for my graduation animation. They're truly a tremendous group to work with, and they have been so accommodating that it has only increased my respect for them. I have always responded visually to music and it's a project I've always been attracted to. When I came across their signature "Progressive ErHu Rock" in the summer of 2007, I knew I had encountered a sound that would be a continuous source of inspiration. I had only dreamed of actually getting in touch with them. So, this undertaking is a huge honor for me. After pouring over their library of work, I selected a track that I felt the strongest connection with and could feasibly animate to based on duration and pacing.
Below is their FULL SONG: "Luxy NYE", it also includes the first storyboard drawings (don't get excited, it's only 5 seconds worth)
Here is a short series of inspirational sketches I produced to start generating ideas for the animation.
My goal is to have finished character Model Sheets and a first pass of storyboards prepared by the start of this April. Since timing and choreography are such an integral part of this project, the storyboards will feel more like a fully prepared animatic, because I have to plan according to the music. That will make for a fun added challenge.
Self-Directed Study Progress Report #2
After a many blood, sweat, and tears…
I arrived at a successful puppet design. The simplest solution really was the best. I used a clay body and there are wires inside the arms to hold them in place. I made a few different mouth pieces to act as key poses and then I would make the in-betweens on site using claymation. My fear with claymation was that it would present too many variables and not hold a pose without skating all over the place. Placing thin wires throughout the interior helped the material hold its shape.
This was also my first attempt at green-screen color keying. I hadn't considered the props on screen. So, had I not included them it might have worked. The puppet works fine with the color keying. The problem is that some of the finer details of the animation are lost after color keying. Once I've completed the entire piece I will include a version that features the color keying.
I edited down and rerecorded "Bottled Frustration". After playing with some mastering settings and changing to a more consistent recording venue, I arrived at a much cleaner audio clip. I voice acted both parts in the final piece. The animation you see above is the first finished thirty seconds. The entire clip is over 50 seconds, which I will have completed by the end of this week. I'll also upload a manual I've been writing that records my findings in working with stop-motion.
I assembled my workstation to allow me to easily access all of my materials without passing in front of the camera or having to change my seated position.
The star of my short film. His arms are a different tone of white than the paper base. I apologize for the picture quality on this one.
Here's a detail shot of the key mouth positions. I kept them on a sheet of paper so the oil of the modeling clay would not stick to the table.
The Canon EOS Rebel XS DSLR is linked to a computer running Dragonframe3. This combination makes for one powerful stop-motion toolset.
The edge of the paper serves as a guide so I know how much table space I have that stays out of the view of the camera.
Complete Exposure Sheet – DopeSheet_Complete
Another great benefit to Dragonframe software is the ability to import audio into your capture timeline. This allows you preview your animation in realtime with the audio clip.


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Past Events › Exhibitions
Events List Navigation
Known as a radical in the book arts world, our 2016 Faculty Fellow, Amos P. Kennedy, Jr., challenges notions of the preciousness of the books to deal with issues of class, economy, and race. I Am Negro features two new printing project installations.
Find out more »Featured Artist Project China Marks: Time Traveler
Time Traveler features recent books, broadsides, and text-based drawings produced in thread and fabric using an industrial sewing machine and a computerized embroidery machine. Marks' artworks depict a present time that is profoundly informed by the past, often re-imagined, and also includes fantasies of the future.
Find out more »Enacting the Text : Performing with Words
Organized by Nicolás Dumit Estévez, performance artist and Independent Curator.
Enacting the Text : Performing with Words gives center stage to artist books, letters, notes, scripts, and texts produced side-by-side with or in complicity with transient gestures.
Making Sense of the Senses
Organized by Alexander Campos, Executive Director & Curator, Center for Book Arts, and Peter Schell, Artist, Instructor, and Naturalist.
As the annual artist members' exhibition, including invited artists, this exhibition presents artists' books and related works that employ one or more of the senses: hearing, smell, sight, taste, and touch. Alternatively, some works conjure a conceptual idea using one (or more) of the senses, or poetically evoke the senses.
Find out more »Sheherzade's Gift: Subversive Narratives
Organized by Jaishri Abichandani, Independent Curator and former director, SAWCC
One of the most enduring and influential books in global popular culture is A Thousand and One Nights. Understood as an amalgamation of fables originating from West and South Asia, its main protagonist is the fictional Queen Sheherzade, whose stories are told to countless young girls from North Africa to South East Asia.
Find out more »2015 Workspace Artists-in-Residence: Aravind Adyanthaya, Joseph Cuillier, Glen Einbinder, Nontsikelelo Mutiti, and Brad Thiele
Organized by Alexander Campos, Executive Director & Curator, Center for Book Arts
In 2015, Aravind Adyanthaya, Joseph Cuillier, Glen Einbinder, Nontsikelelo Mutiti, and Brad Thiele were selected as artists-in-residence. This group show will feature the work completed by these artists last year at the Center.
Find out more »Rosemarie Chiarlone and Susan Weiner: Obstruction
Organized by Alexander Campos, Executive Director & Curator, The Center for Book Arts
Obstruction is a collaborative project between Rosemarie Chiarlone, artist, and Susan Weiner, poet. The work investigates women's struggle for authenticity within societal constraints in relation to clothing through a variety of visual and textual formats.
Find out more »Queering the BibliObject
Organized by John Chaich, Independent Curator, Designer, and Writer
This exhibition features works by queer-identified artists who explore the book as an object for reconnecting to cultural and personal history. This group show is less about the artist book and more about the bibliobject and the artists. It considers not only restricted access to the bound pages but also the idea of repurposing and reframing pages in order to re-imagine the significance of printed literature in socializing personal identities and artistic practices as LGBTQ peoples. Artists included are: Nayland Blake, Eve Fowler, Leor Grady, Garry Hayes, Paul Mgapi Sepuya, Allyson Mitchell, and Jade Yumang, among others.
Find out more »SWEAT Broadsheet Collaboration
Organized by Alexander Campos, Executive Director & Curator, The Center for Book Arts
The SWEAT Broadsheet Collaboration is a collaborative effort of South Florida artists and writers. This exhibition consists of seventy-eight broadsheets in a wide variety of media including letterpress, silkscreen, etching, digital pigment prints, relief prints, monoprints, and many forms of hand work.
Find out more »Chris Perry: Ripples Current(ly)
Organized by Alexander Campos, Executive Director & Curator, The Center for Book Arts
Perry's work, which deconstructs specially-made books into 3-dimensional sculptures, questions our concepts of the book as receptacle for only one type of knowledge.
Find out more »


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Dark Age of Camelot: Gold Edition
Dark Age of Camelot: Gold Edition contains the complete and most up-to-date Camelot saga in one box. The package includes the original game, the Shrouded Isles expansion pack, a free one-month subscription, and a comprehensive introduction to massively multiplayer online gaming. Shrouded Isles extends the story of the original game and enhances the action with new character classes, races, monsters, and three new continents. With an expansive adventure and a 45-page beginner guide, the Gold Edition is a useful introduction to the world of massively multiplayer gaming.
Release Date: June 3, 2003
Latest Reviews
Site | Date | Type | Rating |
Gamers Europe | 05/05/04 | Review | 6 out of 10 |
Worthplaying | 11/30/04 | News | n/a |
GameSpot | 05/25/04 | News | n/a |
GameSpot | 04/08/05 | Patch | n/a |


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NYRA Sends Out Letters of Possible Layoffs
NYRA is required under the Workers Adjustment and Retraining Notification Act that they to have to send out two-month advance word to employees of possible layoffs
NYRA is required under the Workers Adjustment and Retraining Notification Act that they to have to send out two-month advance word to employees of possible layoffs
The financial health of off-track betting corporations in New York is "substantially" deteriorating, and policymakers must react by considering different options.
State officials in New York have agreed on one point: that they will not let the New York Racing Association shut down after the Belmont Stakes (gr. I) or for the Saratoga summer meet.
Legal restrictions foil proposal to keep NYRA solvent through the current year. NYRA says state is behind on payments they promised to make.
New York State has issued a new call for bidders to operate a casino at Aqueduct, nine years after the project was first approved by the legislature.
A group of about 10 Thoroughbred breeding farms and the Saratoga County Chamber of Commerce next week will sue the state of New York to try to force it to loan $17 million to the New York Racing Association.
The New York Racing Association could run out of cash before July 1 under a doomsday scenario provided to its board of directors.
Racetrack casino gambling in New York grew in all but one facility in the past year, as the net winnings of the racinos topped $1 billion for the first time since slots were permitted in the state in 2001.
More than 1,000 unionized workers at New York City Off-Track Betting Corp. are in still in line for pay hikes and severance deals but won't be paid until a long-term agreement is made.
NYRA may get a $17 million loan to help its cash crunch. Meanwhile, New York Off-Track Betting on April 23 cut 35 employees from his staff as it works through bankruptcy reorganization.
Seeking to avoid a "profound" impact on the state's racing industry, New York City Off-Track Betting Corp. will not shut down April 18 as planned.
A top state lawmaker in New York urged the New York City Off-Track Betting Corp. to remain open a few more days to give negotiators additional time to strike a financial rescue plan.
An effort to bail out New York City Off-Track Betting Corp. collapsed April 14, leaving uncertainty over whether the betting giant will have to close its doors the weekend of April 17.
Negotiators are closing in on a deal to keep the money-losing New York City Off-Track Betting Corp. alive for another year, but last-minute sticking points have been jamming up a final agreement the past 24 hours.
The nation's largest off-track betting corporation will be shut down on the night of April 11 if a deal to provide it with financial help does not come together over the weekend, officials warn.
New York state officials are preparing as early as this week to release new bid proposals for the delayed Aqueduct casino project, with a winner expected to be selected possibly by the end of June.
Legislation introduced April 2 would permit a New York state government panel to take over the operations of the New York City Off-Track Betting Corp. if it shuts down.
New York City Off-Track Betting Corp. officials are preparing to seek a bankruptcy judge's help in deferring statutory payments to racetracks and others to avoid an April 11 shutdown.
Officials in New York have failed to agree on a bailout plan for the New York City Off-Track Betting Corp., which issued layoff notices Friday to its 1,300 workers as it prepares to close down April 11.
A plan quietly floated to let the New York Racing Association take over management of the internet and phone wagering business at the struggling New York City Off-Track Betting Corp. has been rejected by Gov. David Paterson.
New York Gov. David Paterson is pushing a plan with legislative leaders to re-bid the Aqueduct casino project, a proposal that could push off a final decision until the end of the year.
New York City Off-Track Betting Corp., facing a possible shutdown, can continue its bankruptcy reorganization case, a federal judge ruled March 22.
With talks to avoid a shut-down of its operations so far stalled, NYCOTB has floated a plan to state officials to permit it to withhold certain payments to tracks and others to remain solvent the next three months
New York officials have scuttled the deal with Aqueduct Entertainment Group to develop a sprawling casino at Aqueduct racetrack, leaving an uncertain future over when the project will ever take shape.
State lawmakers March 10 urged Gov. David Paterson, who is considering pulling the plug on Aqueduct Entertainment Group's casino deal at Aqueduct, to pick from one of the remaining bidders if the AEG contract is scuttled.
The Aqueduct Entertainment Group bid to run a casino at Aqueduct racetrack took another setback, with the withdrawal of two of its most prominent African-American investors.
New York lawmakers have given approval to move the state's equine drug-testing laboratory from Cornell University to Morrisville State College. The Senate and Assembly both approved the move March 1.
In a major sign the Aqueduct video lottery terminal project could be in jeopardy, Gov. David Paterson is no longer counting on the winning bidder to supply the cash-starved state with $300 million by March 31.
A new member of the New York State Racing and Wagering Board has been approved by the state Senate, but not without the usual dose of partisan wrangling at the state Capitol.
The New York Racing Association, which has long resisted revealing salaries of its top executives, has furnished the information to a top state regulator at a time it is warning of running out of cash later this summer.
Asks New York state inspector general's office to look into the bidding process.
Head of state lottery not certain AEG can meet conditions imposed by New York state.
Gov. David Paterson has recommended Charles Diamond to a state board with vast regulatory authority over New York's racing and gambling industries.
Getting a casino at Aqueduct could be delayed further by political in-fighting.
New York Gov. David Paterson and legislative leaders have tapped Aqueduct Entertainment Group to run a sprawling new video lottery terminal casino at Aqueduct.
Foot-dragging and midstream rule changes look like prejudice against Penn National Gaming, according to Peter Carlino, the Pennsylvania-based company's CEO and chairman.
A state task force is recommending a series of changes in the law to address new competition for dwindling betting dollars and repair a situation that has created a damaging war in New York racing.
New York City Off-Track Betting Corp. officials Jan. 25 moved another step nearer to shutting down with approval of letters to employees giving them the legally required notice of a March 30 closure.
The New York Racing Association, as expected, backed down from its refusal to cooperate with a review of its finances by the state's chief fiscal watchdog.
The nation's largest off-track betting corporation, now under federal bankruptcy protection, faces closure in the next 60 days unless the state officials OK its recovery plan.
The New York City Off-Track Betting Corp.'s bankruptcy petition and attempt to alter how it funds the industry risks undermining the state's already hard-hit breeding programs, New York's leading breeding group is warning.
The recent bankruptcy petition by the New York City Off-Track Betting Corp. should be tossed out of federal court, the New York Racing Association argues in a lengthy legal brief filed Jan. 4 in Manhattan.
Frustrated by the delay in picking an Aqueduct casino operator, New York Gov. David Paterson said he is moving to publicly name his choice in hopes of putting pressure on legislative leaders to make a decision.
The New York Racing Association, which says it will run out of money next year, will not open up its books to let New York's chief fiscal watchdog examine its operations to verify those claims.
NYRA president Charles Hayward said the state needs to choose a casino operator for Aqueduct or the association will run out of money in June, which puts the Belmont Stakes (gr. I) at risk. As of now, the race will be run.
The federal government has given preliminary recognition to a Long Island Indian tribe, setting in motion development of a possible casino close to the New York Racing Association's two downstate tracks.
New York's rules governing racetrack and off-track revenue-sharing took another twist Dec. 15 as state racing regulators ordered four downstate off-track betting corporations to pay millions of dollars to Yonkers Raceway.
After nearly four decades, New York's Cornell University is moving to close its world-famous equine drug-testing laboratory. An equine science program at a state university 70 miles up the road is eagerly willing to take over, and expand, an operation vital to the state's horse industry.
Negotiations for an Aqueduct casino operator have stepped up again, with a new flurry of talks between Gov. David Paterson and legislative leaders occurring in advance of a return by the state legislature the week of Nov. 16 to deal with New York's soaring deficit.
All five remaining bidders for the Aqueduct gaming project said they have met a Nov. 6 deadline to guarantee a quick $200-million payment to the state of New York if they are chosen to develop the video lottery terminal casino at the Queens racetrack.


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Alienbear Gupte Designs Blog
Monday, June 11, 2007
Princess Calanthe
Close up of back view:-
Avaliable at Alienbear Design, Le'Bear Castle Bratz 1/F Formal Jewelry set section.
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Opened in Virtual World Secondlife since Oct 2005. Simple but Elegant; Detail & High quality Handcrafting prim work; Innovative & Creative; Original Creations are what my design presented. Here you can find all of my creations start from Jan 2007 including new release, retailed, limited edition, & member gifts design.


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An oversize load that missed its exit caused a backlog on I-80 Saturday morning, according to police.
The 15'4" truck ended up striking an overpass, scattering debris on another vehicle and leading crews to close one lane of the interstate.
Police said that around 9 a.m., a truck with an oversized load crossed over the Delaware River from New Jersey.
The truck failed to follow its instructions to exit at Exit 310 (Delaware Water Gap).
The truck continued west, where it struck an overpass that it wasn't permitted to drive under.
The impact caused debris to fall onto another vehicle, but no injuries were reported.
One lane of I-80 was closed for about 3.5 hours as crews worked to remove the truck.
Saturday morning traffic blamed on oversized load
Apr 13, 2014 at 1:52 PM
Apr 13, 2014 at 1:59 PM


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Be Her Greatest Lover
What am I talking about? I'm talking about being the best lover that she regrets losing; an ex-lover that she keeps coming back to because her current mate is nowhere close to the passionate lover you are; the lover that no woman would ever leave for another man — unless he's really rich; or the yearned for lover inside her circle of friends.
That's right boys, if you play your cards right, you'll have women walking their dogs in front of your bachelor pad, hoping to see your lights on. Because once you earn the trademark of a great lover — a unicorn— women will cherish your presence forever.
a little touch
The only way of achieving this is by taking advantage of other men's natural laziness and do all the things a woman desires, but has never experienced because her lovers were too flaky .Aside from being a skilled lover, the secret ingredient required to jump up a level from a good lover to a unicorn lover, is to spontaneously mix a little fun and games into the sexual formula. Let me tell you about Anya, my most precious lover to date.
passion enlightens the soul
Everything about this woman was beautiful; her hair was a silky black color that always smelled like fresh strawberries, her soft skin reminded me of the taste of sweet vanilla, and her warm brown eyes always found a way to enlighten my soul.Everything about Anya was passionate, from her views about life, to her loyalty, to her tender kisses, to her orgasms. I never met a woman that brought out so much passion within me. And on one particular rainy late afternoon, I decided that I would repay the favor.
the shopping list
For this particular night, it was going to be an all-night affair; hence, I would require multiple props to assist me with pleasuring my passionflower. Here's a sample of some of the props I played with:- 24 candles (white)
- 24 candleholders or saucers
- Music (at least 4 CDs; Moby, EBTG, Delerium, and Paul Oakenfold)
- A new silk robe (black)
- Her favorite beverage (champagne for the lady)
- Her favorite fruit (strawberries of course)
- 3 notes
- 1 chair
- Bubble bath
Massage oil
- 2 blindfolds
- Feather
- An angel bell
Yes, I know it's a long list, but like I said, it's going to be a long night... a very long night.


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Väderstad E-Control is a control system developed by Väderstad which enables farmers to control the machine using an iPad. The control system is available for Tempo and all versions of Rapid.
A user friendly interface and the large screen on an iPad make it easy to control Tempo and Rapid. Using a standardised technology makes it also a lot easier for the end-user compared to proprietary systems. The iPad is placed in a holder with several hard buttons for easy manoeuvring of the machine. The communication between the machine and the iPad is through a wireless secure network. An Internet connection is not necessary. "With the introduction of Wi-Fi and iPad Air, the Rapid machine and other equipment can be guided with the help of wireless communication. User-friendliness, cost-effectiveness and easy of update are just some of the major advantages with the iPad Air solution compared with previous systems" says Lars Thylén, Concept Manager for Rapid.
With an ISOBUS platform and a tested Task Controller in the tractor, it is possible to use the ISOBUS to turn the seeder on and off at headland. At the same time the function of the machine can be supervised on the iPad.
Väderstad ABHogstadvägen 2SE- 590 21 Väderstad
Phone +46 142 820 00Fax +46 142 820 10
Our business idea is to supply modern agriculture with highly efficient machinery and methods. Developing machines and methods that help make farming more efficient is in Väderstad's genes.
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