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Events for Week of October 11, 2010
Written by Jess R.
A low key weekend began with a Dogfish Head Punkin Ale at Whisk(e)y Bar (my new favorite, local watering hole), several Firestone Walker Union Jack IPAs, a New Belgium/Elysian Trip III and several Fresh Hop beers (it was a rough week at work, ok). Other beer highlights include Port Brewing's Old Viscosity, an imperial stout worth a moment of silence and a couple of tall boys of Rainier. And now for your week in beer.
Monday, October 11, 2010
" I Love New York" Beer Week Begins: New York, New York
All week @ the Spring Lounge
Start spreading the news, its All New York, all week, with beer from Brooklyn, Ommegang, Captain Lawrence, Ithaca Brewing Co., Greenport Harbor, Coney Island, Sixpoint, Southern Tier, and more. Check out www.beermenus.com for details on the special events this week.
Tuesday, October 12, 2010
Green Flash Night: Whittier, California
7:00PM-9:00PM @ The Bottle Room
Not only will all patrons receive discounts on beer, the first 36 guests will receive a complimentary Green Flash Brewing Co. pint glass with the purchase of a regularly priced draft (minus $1 for LA Beer Week). From there, bring your pint glass in and receive a $1 off Green Flash drafts until the kegs are kicked. Green Flash flights will be available–4-4 ounce pours for $11. Expect some special Green Flash beers not available elsewhere to the public.
Wednesday, October 13, 2010
Avery Rumpkin Release: Boulder, Colorado
6:00PM-9:00PM @ Avery Brewing Co.
AN IMPERIAL PUMPKIN ALE AGED IN RUM BARRELS. Stop by Avery Brewing Co. (where the magic happens) and experience the release of what sounds like am amazing, seasonal brew. Imperial Pumpkin Ale brewed with pumpkin puree and a blend of five spices. Aged in extremely fresh Gosling's Rum barrels for six months. Consume fresh and often, preferably with a pumpkin pie and/or s'mores.
Thursday, October 14, 2010
Unibroue Beer Tasting: Cincinnati, Ohio
6:00PM-8:00PM @ Catskeller
Just $10.00 and you get beer from Unibroue paired with small plates. What a deal! The menu reads as follows:
Maudite: with bruchetta
La Fin Du Monde: with bacon scallops
Ephemere: with brie and apricot phylo
Don de Dieu: with smoked turkey club with feta cut in fourths
Terrible: with sharp cheddar quiche
Trois Pistoles: with rich chocolate brownies
Friday, October 15, 2010
Cleveland Beer Week Begins: Cleveland, Ohio
From the website:
The second annual CLEVELAND BEER WEEK will take place from October 15-23, 2010. A celebration of craft and import beers, CLEVELAND BEER WEEK features plenty of tastings, dinners, activities and more at more than 100 venues throughout Cuyahoga County and beyond. We hope you will join us as we celebrate the world of craft and imported brews at CLEVELAND BEER WEEK.
This beer week will not disapoint with participating breweries such as Hoppin' Frog, Thirsty Dog, Great Lakes Brewing Co. and more. As if you weren't excited enough, 12 breweries who participated in the largest known collaboration of its kind in the world, creating six brews. Family members have already agreed to mail us a six pack. Oh man! For more information, visit the event site.
Saturday, October 16, 2010
Great Pumpkin Beer Fest: Seattle, Washington
(Saturday and Sunday) 12:00PM – the beers get tapped and the place shuts down @ Elysian Brewing Co., Capital Hill Location
I know we already did a write up about this event, but I am so damn excited, I had to mention it here- click here for details about the event from bb.com. Expect a crowd, a well-deserved crowd of people thirsty for pumpkin beers from Elysian, Russian River, Jolly Pumpkin and so many more. Sour pumpkin beers, pumpkin stouts, spiced ales and possibly beer brewed in a pumpkin. Also, get there early and you might get a sweet little taster glass (at least we did last year).
Sunday, October, 17, 2010
Farmhouse Ale Dinner: Philadelphia, Pennsylvania
5:00PM-9:00PM @ The South Philadelphia Taproom
All you can eat harvest foods and beers for $50.00 (includes tax and tip). Featured beers include: Ommegang Hennepin, Sly Fox Saison Vos, Saison Dupont, St. Feuillien and more!
If you go to an event, want to talk about an event or a beer you had at an event, leave a comment or email us at email@example.com. Cheers!
Events for Week of July 19, 2010
This was a good beer weekend.
A trip to Portland entailed Stone, Dogfish Head, Victory collaboration Saison Du Boef; Avery Maraja; Hair of the Dog Fred; Russian River Consecration; Double Mountain Saison and so much more! A trip to a new beer bar Apex was top notch (see our 52 weeks article later) and bottle shop, Beermongers was still impressive and reasonable priced!
As if that wasnt enough, we partook in an impromptu beer tour of Southern Washington up through Tacoma. With a Dogfish Head Sah' Tea at Parkplace Tavern in Tacoma and a Lagunitas Lil' Sumin' Wild in Olympia, letting go of the weekend was very difficult. But there is a whole week ahead of us and plenty of beer events.
Monday, July 19, 2010
Captain Lawrence Imperial Porter and 2 Casks tonight!: Peekskill, New York
6:00PM-10:00PM @ Birdsall
Tonight a keg of Captain Lawrence's new Imperial Porter will be tapped along with two exclusive CL gravity casks: Kolsch & Freshchester(dry hopped with Cascade hops). Dont miss out on this full Captain Lawrence line up, including a couple of new draught additions.
Tuesday, July, 20, 2010
Deschutes Night: Seattle, Washington
6:00PM-9:00PM @ Naked City Brewery and Taphouse
Tonight, Naked City features Bend, Oregon brewery, Deschutes. Known for amazing beers such as Abyss, the tap list includes Miss Spelt, Hop in the Dark, Jubel 2010 and Greenlakes Organic Ale. Enjoy!
Wednesday, July 21, 2010
Hoppin' Frog Tasting: Shawnee, Kansas
7:00PM-9:00PM @ Barley's Brewhouse
I am really happy to see Hoppin' Frog, this Ohio based brewery get some love outside of its home state. Tonight, for $20.00 you can taste the following (they are all o' so good) with some delicious food pairings: Wild Frog Wheat, B.O.R.R.I.S the Crusher Stout Paired with Teriyiaki glazed Wings, Mean Manalishi, paired with Fish and Chips, Silk Porter paired with our Chocolate Tort and Hoppin' to Heaven IPA.
Thursday, July 22, 2010
25 Tap Bells Night: Grand Rapids, Michigan
6:00PM-2:00AM @ HopCat
I know we have posted a couple of events similar to this one, but it is so amazing. 25 taps of Bell's Brewery beers tonight including: Two Hearted Ale (poured from a tap and from a firkin), the Cherry Stout and an '08 Expedition Stout. SO good….so good.
Friday, July 23, 2010
Meet the Brewer of Brooklyn Brewing Co.: New Orleans, Louisiana
10:00PM- 12:00AM @ The Avenue Pub
We all know how much we love this place. So lets take this place in all of its glory and throw some Brooklyn Brewing beers on tap. Sold! Tonight, for $12.00, meet Garrett Oliver, head brewer and taste a sample of 5 amazing brews.
Saturday, July 24, 2010
Barleywine Fest: Largo, Florida
5:00PM-11:00:M @ Willard's Tap House
Granted its not barleywine season. Its summer after all. However, stop by Willard's tonight and sample some flavorful beers including: Sierra Nevada Bigfoot, Weyerbacher Blithering Idiot, Southern Tier Back Burnner and Avery Hog Heaven (a hoppy barleywine).
Sunday, July 25, 2010
Rooftop Summer Wheat beer Dinner: Raleigh, North Carolina
7:00PM-9:00PM @ the Busy Bee Cafe
Now, sometime deliciously appropriate for the summer months, a wheat beer celebration. It'll be a little more laid back than Busy Bee's usual beer dinner and is only $35 per person. Enjoy Blanche de Bruxelles, Schneider Weiss, Great Divide Dunkel Weiss, and Terrapin Gamma Ray all on draft for this 4 course dinner! Email firstname.lastname@example.com for tickets or more info.
Whats in stock for your beer future? Plan on attending an event? Want us to post an event? Then please leave a comment or email us at firstname.lastname@example.com! Cheers!


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Cape Cod Patio | Falmouth Ma
April 4, 2012 by insideout
The weather has been beautiful the past couple of days here at The Captain's Manor Inn which is helping us to get some important outdoor work completed on the new construction. The finishing touches are being done on the new main entrance stairs to the veranda and Kevin has been very busy creating the new brick patio at the base of the stair entrance. Needless to say his back and knees are a bit sore!
Hope you enjoy these pictures of the progess.
Katherine Lee Bates Room Construction
March 30, 2012 by insideout
Hard to believe that less than 60 days are left until we reopen the Inn. The tiling of all the new bathrooms is well underway and the crown molding and wood trim is in process. The Bates room is a fun room to capture as it progresses. We posted a short video below that we hope you enjoy 🙂
Construction Update | Cape Cod
March 12, 2012 by insideout
Progress continues with the rough in for the electrical and plumbing/heating complete. It is incredible to see the amount of wire and piping that is going into the addition.
Our plumbing and heating professional is someone we used when we lived in Western Massachusetts and we are so pleased that he traveled out with his team to do our work. He is a great professional and a patriot as you will see from his truck.
Look at the intricate valves for all the plumbing lines for the new bathrooms and heating systems in the addition!!!
Interior Framing of New Rooms |Falmouth | Bed & Breakfast
February 22, 2012 by insideout
As the winter continues to be mild we are VERY thankful. The exterior walls of the Inn have been opened into the new addition as the framing of interior walls, rough in plumbing and rough in electrical begins. Needless to say it is quite dusty and drafty, we can just imagine how cold it would be if it were a typical winter:)
Thought you might enjoy some pictures showing the breakthrough and also some of the new rooms being framed out.
Window Art | Robin Pierson | Cape Cod
February 17, 2012 by insideout
We are very pleased that as part of our Inn expansion we will be adding a wonderful piece of art to the Canopy room. The Captain's Manor Inn has wonderful original windows with plantation shutters that we have worked hard to maintain as we renovate and add on to the property. In the Canopy room we are in the process of taking out the old bathroom and an old closet and that space will now become part of the living area of the bedroom. We are also adding on a new bathroom which will feature custom tile work and a large 5 x 4 foot shower. To do this work we are adding to the back of the room and we have decided to keep the old window and plantation shutter but to create a work of art highlighted within the window as specialized in by Robin Pearson. We will keep you posted on the progress but in the meantime here are some pictures what has been taken out and some initial work by Robin as well as an example of her work from another project. Enjoy.
Winter Really Exists on Cape Cod
January 16, 2012 by insideout
It is bitterly cold out today! After an incredibly mild winter to date the artic freeze started yesterday and is in full force today. That has not stopped our wonderful framers from working hard to keep the addition on track. Over the weekend Kevin and I recruited our two young adult children to form a painting production line. The story is that we are replicating 174 brackets on the wrap around veranda and our architect had them made and shipped from Georgia. They arrived on Friday and had to all be painted by Monday for the framer to get them on the house in preparation for the siding work to begin. So here we are on Monday and the brackets are being attached as I write this. Some pictures of this part of our Cape Cod bed and breakfast project are shown below:
Captains Manor Inn Construction Update
January 2, 2012 by insideout
Happy New Year to all!! The construction is moving along but as anyone who has been through it knows there are hiccups along the way 🙂 Good news is that we just had the driveway initial paving done before winter hits (at this rate winter may not hit seeing as it was 50 degrees yesterday!). The hope is that in about one week the entire roof will be complete. At this time the roof is on the new veranda and the plywood sheathing is almost complete on the actual roof over the living areas. The cupola is also under construction on top of the new addition.
B&B Construction Update |2nd Floor Blueprint
December 12, 2011 by insideout
Framing of our cape cod bed and breakfast addition underway
December 12, 2011 by insideout
The expansion of The Captain's Manor Inn really seems to be coming to life now. The foundation is complete with the pouring of the ground level floor. The framing is well underway with the ground level and first level exterior walls complete. Hope you enjoy the pictures below 🙂
Holidays at Highfield | Falmouth Ma
December 7, 2011 by insideout
Just a short walk from the Captain's Manor Inn the season of holiday merriment is in high swing at historic Highfield Hall! For the past two weekends, the mansion has hosted "Holidays at Highfield," a chance to for the public to view the elegant rooms decked out in their holiday finest. Below are some wonderful photos of the decorations and handmade creches from all over the world.
Photos are from the Falmouth Patch and click here to see additional photos.


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Photographer's Note
The Himba people live in the Kaokoland- Kunene region, in north western Namibia.
Near the Kunene river and Epupa waterfalls in a little vilage, I filmed that beautiful girl, all covered with red Ocra.
Critiques | Translate
Very, very good. She looks like she is dusted in cocoa! She looks strking against the blue sky, and I like the contrast of her skin with the belt. Her breasts, shoulder string and necklace produce an interesting symmetry. As for her expression, that's what makes this photo great.
kooreman (321) 2004-07-19 15:55
A very special portrait of this woman completely in one color. The interesting and at the same time strange thing about her is that she is all in one color. A real body has different colors and that's what gives me a strange feeling with this shot.
It is well shot, with great sharpness. The strong contrast of the shadows add to make the shot more intrigueing.
Greetings, Jan
jackwp (519) 2004-07-19 16:01
Great capture. She is a fine example of the proud people of her area. Nice colors and clarity.
jrzufferey (7305) 2004-07-19 16:31
Bravo pour ta photographie elle est superbe. Ces femmes vêtues de cuir et enduite de cette belle terre rouge du Kahalari, magnifique. ça me fait penser aux bochimans ou aux Hereros .Bravo magnifique\jr
ishai (4097) 2004-07-19 16:45
Thanks for bringing Africa closer to us
Great colors
I like the accessories on her (I mean the belt and the necklace
Impresionante retrato Eyal.
Por colorido y por originalidad es un excelente trabajo.
Impressive picture Eyal.
By colorful and originality it is an excellent work.
waskahegan (0) 2004-07-19 20:21
The Himbas, lovely and proud people. You got a good portrait here the facial expression is excellent.
richtersl (3546) 2004-07-19 22:16
This is a fantastic portrait! The colors are great. Thank you for sharing this.
centurion (0) 2004-07-20 0:21
Well done. Good portrait picture with a wonderfull colour and face expression.
elroyie (2750) 2004-07-20 3:08
Great portrait, very interesting and very special one, well done!!!
:-)) tomorrow
jhonny_blue (4956) 2004-07-20 4:25
Fantastic shot Eyal ! She is so beautiful and his clothes are fantastic.
Wonderful picture !
Very well done !
sn00zie (2384) 2004-07-25 14:36 [Comment]
Gerry (0) 2004-08-18 17:59 [Comment]
rinusj (64) 2004-09-14 15:34
nice deep colors, everything on the body is sharp.
A bit from below taken
Nice shot.
Xalkida (11744) 2004-10-22 14:27
Brilliant photo! The colors and the lighting are awesome! The expression of the girl is also magnificent! Brilliant work!
gazo (116) 2004-10-25 8:00
You did a very good portrait. Good subject and nice colors. Interesting the ocra on all her body. We can see this people are proud of their beauty. Look the attitude in the girl's face.
Thanks for make dicovering the Himba to us.
Luan (12971) 2005-03-06 13:12
Wow, she looks like a chocolate sculpture or statue. Wonderful colors and portrait. Godd DoF
Thanks for sharing.
archanabhimasen (270) 2005-04-14 8:55
She is all the more enhanced because of the plain blue background.
sfgiant (480) 2005-11-07 19:54
Great shot. Colors, expression, composition. It all works. Interesting that the one criticism you got was from someone who hasn't posted any photos. Lighten up Gerry!
Well done
annagrace (2467) 2005-12-18 17:18
Wonderful contrast of her lovely skin against the blue sky. Excellent lighting, well seen!
Papendieck (0) 2005-12-18 18:08 [Comment]
siamakjafari (1527) 2006-10-07 16:25 [Comment]
rui_seabra (205) 2006-10-07 16:48
People come in all shapes and colors...
And you captured a rare combination - at least for an european!
I like the angle but I would have reduced the brightness slightly...
Thank you for such a different photo.
PS. and Gerry... it's all in your mind... it's all in your mind...
You should learn a few things of life before you TRY commenting art...
Rui Seabra
enedimd (1532) 2007-04-28 14:34
Hello Eyal,
Great shot. Nice color and sharpness.
Perfect portrait. Lovely and Proudly Beatiful girl.
Have a nice day.
Emir Nedim
Gankaku (20) 2009-05-24 18:01
I rarely like photos of people, and never nude photos. This one is so awesome - her skin color is so uniform (I think this is why I like it so much) and she's beautiful with all the accessories. Very unique photo!
Photo Information
- Copyright: EYAL BARTOV (bartove) (2866)
- Genre: People
- Medium: Color
- Date Taken: 2000-00-00
- Categories: Daily Life
- Camera: Canon EOS 1v, Canon EF 100-400 L, Fuji Provia 100
- Photo Version: Original Version
- Theme(s): naked africa, * more favorite photos (II), Traditional Costumes of Africa II [view contributor(s)]
- Date Submitted: 2004-07-19 15:30
- Favorites: 9 [view]
- To Gerry: :-| duh (1)
by rui_seabra, last updated 2006-10-07 04:46


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2013 WSOP, Day 30: We Will Rock You
Can't really write too much this morning, though, as I've had to deal with some unplanned stuff here at the home-away-from-home (short version: a room change was needed), and so time is tight. Thus I can't really chronicle all that Vera and I did yesterday as we enjoyed running around Las Vegas.
We spent the afternoon shopping up at the Fashion Show Mall on the Strip, then in the early evening we were able to meet up with my cousin's husband, Tim, who just happens to be in town this week for a conference. He also just happens to have been born in Las Vegas, having lived here as a child through the '70s. Thus he had a few stories to tell about how Vegas was during those years, as well as some other second-hand anecdotes via his parents who had lived here from the early '60s until their move.
From there Vera and I went to the Bellagio for some dessert, some people watching, and a well-timed trek outside to see the fountains do their thing. Vera then said she wanted to see Fremont Street -- somehow during all of these visits we'd never gotten her down there before -- and so we drove out to check it out, arriving around 10 p.m.
Our timing was again good, as we had just walked out of Binion's when the lighted canopy show featuring Queen's "We Will Rock You/We Are the Champions" was cranking up. After that we had fun walking up and down the street, taking in all of the crazily costumed characters and other mostly-mild-but-a-little-wild mayhem.
A partial list of the cast included a couple of Transformers, KISS look-a-likes, Spider-Man, Tickle Me Elmo, Hello Kitty, people in full-feathered, head-to-toe Native American garb, other unidentifiable Renaissance Fair-looking types, lots of skin, a few pasties struggling to cover, and a band (Arena) also sweatily covering (with a little less difficulty) Van Halen, AC/DC, and the like.
On our way back through Binion's I also showed Vera the lonely poker room (trying but not succeeding to get one table going), and the walls full of pictures of WSOP winners (through 2005) and Poker Hall of Fame members (also through 2005).
It was another full day of fun for us, and kind of made it easier to deal with the room-change hassle today, which would have been a lot less pleasant had it come at the beginning of Vera's visit rather than the end. The trip to the Strip then Fremont was kind perfect, too, demonstrating vividly the contrast between the two locales for Vera as she got to witness Vegas rocking its hardest. Was interesting, as well, to soak in Vegas today and think about how utterly different it was from when Tim had lived here.
Vera is around until tomorrow, so she will get to do some more shopping today while I work. I think also we'll try to get her over to the Rio for my dinner break tonight so we can test out that All-American Dave food everyone has been raving about at the WSOP this summer. Meanwhile, as much as the time off has been great, I looking forward to getting back on the floor to see how the 10-game mix event plays out today and tomorrow.
If you're curious as well, click on over to PokerNews for the live reports.
Labels: *the rumble, Bellagio, Fremont Street, traveling, Vera Valmore


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Original Art:
On the next daytime talk
"Men who kill their brothers and marry their sister-in-laws and the nephews who want
to kill them."
Left to Right: Gertrude,
Claudius, Hamlet, Ophelia
This whole site © Katie Sullivan.
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Heirlooms in MoP, worth it?
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Is it worth it to keep using heirlooms past 85? They don't increase in stats, but the +x% XP still works right? Will the bonus XP offset the slower kill speed of the lower stats?
Right now I'd lose like 900 Intellect (plus other useful stats) if I used my 1-80 Heirlooms, so it doesn't seem like the +20% XP would offset the extra killing speed.
But with my 1-85 heirlooms it's only about 200 Intellect for +15% XP...
Any thoughts, or math to show one way or the other?
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No; the Heirloom's EXP gain stops at the cap for the 'loom: Level 80's stop at level 80 and the 85's stop at level 85.
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Ah. Well I guess that makes the choice easier. Thanks.
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Lot 3511: Dinky (Hornby Series) No.21 Hornby Train Set
Specialist Sale
by Vectis Auctions Ltd
25 October 2016
Stockton on Tees, United Kingdom
Live AuctionSold
Looking for the realised and estimated price?
Description: Dinky (Hornby Series) No.21 Hornby Train Set (modelled miniatures) comprising of locomotive, red, blue, open wagon, green, blue, log load, blue, red, brown log; tanker red, blue and crane, green, blue - conditions are generally Good Plus to Excellent in a Good Plus marble box, lid with paper label is Fair - still displays well.


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Buckling (fish)
From Wikipedia, the free encyclopedia
A buckling is a form of hot-smoked herring similar to the kipper and the bloater. The head and guts are removed[1] but the roe or milt remain.[2] They may be eaten hot or cold.
The word may come from the German Bückling or the Swedish böckling, both words denoting a hot-smoked variety of the kipper.
Bucklings, bloaters and kippers[edit]
Buckling is hot-smoked whole; bloaters are cold-smoked whole; kippers are split and gutted, and then cold-smoked.
See also[edit]
- ^ Food Chemistry, Springer, 27 February 2009, retrieved 30 March 2011
- ^ "Buckling". Retrieved 30 March 2011.
External links[edit]
This fish-related article is a stub. You can help Wikipedia by expanding it. |
This food-related article is a stub. You can help Wikipedia by expanding it. |


text:
It seemed that with his extended hiatus from FX's "Louie," Louis C.K. didn't have a horse in this year's Emmys race. But anyone who tries to predict what Louis C.K. will do next is playing a foolish game.
READ MORE: Watch: Louis C.K.'s 'Horace and Pete' Brilliantly Recut As A Sitcom
For example, before this January, we never would have called that C.K. would take it upon himself to create "Horace and Pete," a fully independent dramedy series starring himself and Steve Buscemi as cousins and co-owners of a bar where people like Edie Falco, Steven Wright, Aidy Bryant and Jessica Lange show up. And now, according to The Hollywood Reporter, C.K. is reportedly planning to submit the series for Emmys consideration this year.
Available for purchase directly from C.K.'s site for $2-5 an episode, "Horace and Pete" has so far premiered nine episodes, which have been as short as 30 minutes and as long as 70 — given the new definitions between half-hour and hour-long programming (a.k.a. the new definition of "comedy" and "drama," per Emmy rules), "Horace" would compete as a drama.
The bigger issue, though, is the series' distribution strategy. By being released not through a streaming service like Netflix, but instead as individual VOD episodes, the show could violate this section of the Emmys Rules and Procedures:
"Television programs that are offered for sale on home video devices or offered for sale by means of electronic sell-through on the Internet prior to their first airing or Internet exhibition are not eligible, unless such offering occurs within seven (7) days prior to the program's original airing or Internet exhibition."
Technically, the series' "first Internet exhibition" is via VOD through C.K.'s site, but it's still offered for sale on home video devices. If that's all it takes for a series to become eligible, the floodgates could come crashing open. Think about it: How many independent TV shows are available for purchase via Vudu or Vimeo that would qualify in this scenario? Programs broadcast on television have to reach a minimum of 50 percent of the "total potential U.S. television audience," a figure immeasurable for streaming networks like Netflix, but entirely inadequate for anything available without a subscription (at least Netflix does tell us how many subscribers it has). That's the main reason the "or Internet exhibition" language was added in years ago, but how it applies to C.K.'s distribution method is fuzzy, at best.
UPDATE: According to John Leverence of the Television Academy, via email, "Horace and Pete" is not only eligible, but officially entered for consideration. "As Louis CK has done before, his series' episodes are posted and can be downloaded then and there for a fee. It's pay as you view TV, and pay TV per our rules is eligible," he said. "The rule cited is the so-called PBS Pledge Drive Exception to the rule that straight-to-video entertainment is not television and hence not Emmy eligible except in cases where, say for example, your local PBS station pitches its big Pledge Drive special with a DVD of the same within the week that the heavily promoted special airs."
While the news could be seen as a boon for independent TV, especially if C.K.'s series earns a nomination, another fascinating element of the decision is strictly financial. Some fuss was made when "Horace and Pete" was first released over the cost of the pilot episode — $5 — to which C.K. responded via a statement on his site: "The dirty, unmovable fact is that this show is f—ing expensive. […] Basically, this is a handmade, one-guy-paid-for-it version of a thing that is usually made by a giant corporation."
While it's admirable he's putting art before profits, how will that rationale apply when it comes time to mount an expensive Emmys campaign? The "giant corporations" typically spend millions on campaigning, and it wouldn't seem likely C.K. could match them. Does it make the submission itself pointless? Not necessarily, but the challenges are already quickly stacking up.
If "Horace and Pete" is in fact proven eligible despite the above issues, it faces one of the toughest races in years. But again, that cast is hard to beat, and it's hard not to admire C.K.'s guts when it comes to both what he creates, and how he chooses to create it.
READ MORE: 2016 Emmys Predictions: Outstanding Drama Series
More mainstream fare from Louis C.K…


text: Yeah, The Fantastic Four's Fantasticar Has A $%&# HEMIRay Wert3/26/07 9:42pmFiled to: Movie CarsDefamerFantastic FourTrevor CreedDodgeHemi22EditPromoteShare to KinjaToggle Conversation toolsGo to permalink This image was lost some time after publication. The summer sequel to 2005's Fantastic Four flick, titled Fantastic Four: Rise of the Silver Surfer, finds the quartet of super-freaks behind the wheel of a new vehicle capable of pushing the fictional limits to 550 miles per hour and 30,000 feet. Now here's the fun part. The film version of the car was created with a lot of input (and marketing dollars) from the Chrysler Group's chief stylist, Trevor Creed. As such, the Transformers-less automaker's turned the new Fantasticar into a Dodge. And yeah, as you can see in this close-up or in the full original-size picture, we're told it's got a HEMI. We're going to go and vomit now. Advertisement Fantastic Four Get HEMI Power [TheCarConnection.com]Related: Transformers Movie Update: New Vehicle Pictures From Edwards Air Force Base! [internal] Reply22 repliesLeave a reply


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TRAF3IP2 / ACT1 antibody was raised against synthetic peptide C-PDTGHDSDKSDQ from the C or N-terminus of human TRAF3IP2 / ACT1 (NP_671733.1; NP_679211.1). Percent identity by BLAST analysis: Hamster, Dog (83%). | ||
aa159-170 | ||
Human TRAF3IP2 / ACT1. This antibody is expected to recognise both reported isoforms (NP_671733.1 and NP_679211.1). | ||
Peptide ELISA: antibody detection limit dilution 1:2000. Western blot: Approx 65kD band observed in lysates of cell line MCF7 (calculated MW of 64.7kD according to NP_671733.1). Recommended concentration: 1-3 ug/ml. |
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide | |
Store at -20°C. Minimize freezing and thawing. | |
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Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kB associates with IkB proteins in the cell cytoplasm, which inhibit NF-kB activity. IkB is phosphorylated by IkB kinase (IKK) complex that contains IKKa, IKKb, and IKKg.


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Height: | 5-5 |
Year: | So. |
Hometown: | Babylon, N.Y. |
High School: | Babylon HS |
Position: | D |
Appeared in 16 games for the Lions, starting four games... Scored one point off of one goal... Posted a perfect 1.00 shots on goal percentage... Collected four ground balls and forced one turnover... Scored her goal against Converse on 4/19/14.
Played in all 15 games, earning seven starts in her first year with the Lions... picked up 10 ground balls and caused four turnovers on the season... first collegiate appearance came against Molloy on February 15... earned a career high three ground balls against Belmont Abbey on March 9... caused a career best two turnovers against Belmont Abbey.
Played for Babylon High School under the direction of Timothy Harrison.
Born June 16... daughter of Joe and Debra... has two brothers, Michael and Shane... hobbies include surfing, swimming, singing, lacrosse, soccer, and dancing... career goal is to be a principal or successful business administrator... lists her hard work and positive attitude as her best assets to the team... names Hope Solo as her favorite athlete... favorite sports team is the New York Giants... chose saint leo because of the small class setting, and beautiful Florida weather.


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Elf on Broadway
*Promotions listed are subject to change without notice and based on availability. We make no guarantee that the promotions listed are available.
Elf on Broadway Information
Show Quick Facts
- Elf Broadway NYC runs from Nov. 9- Jan. 6 for the holidays.
- Elf the Musical is based on the 2003 Will Ferrell holiday classic, "Elf."
- The Elf Musical on Broadway is a family-friendly NY musical appropriate for all ages.
Show Info
Show Dates:
Nov. 9, 2012- Jan. 2, 2013
Hirschfield Theater
302 W 45th St
New York, New York 10036
View Map
User Average Review
Overall: Acting: Ambience: Production: Story:Based on 0 reviews
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Elf on Broadway Reviews
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*Some images shown above are not actual photos from the show, but category representations. Visit the show's web site for actual photos.
Elf on Broadway
Do you agree? Write your own review!
Elf the Musical Takes on This New Holiday Classic
Located in
Midtown West
Features: Get in the Christmas spirit with a new holiday classic - Elf on Broadway, playing at the historic Hirschfield Theater in Manhattan. The new Elf Musical on Broadway debuted in 2010, and runs from Nov. 9- Jan. 6. for the holiday season, but Elf on Broadway will be back year after year. Check back for updates on the return of Elf and enjoy the adventures of Buddy the Elf and his journey to the Big Apple in this fun take on the 2003 Will Ferrell movie.
Why We Go: No Will Ferrell? No problem. Elf on Broadway features a talented cast and colorful, extravagant sets - including a skating rink on stage - and enough candy cane stripes and snowflakes to impress even the biggest Scrooge in your group.
- Family-Friendly: Elf on Broadway is a family-friendly NY musical that will leave your kids happy and entertained, while adults will enjoy smart jokes aimed at an older demographic and meant to fly right over the young ones' heads.
- Faithful to the Movie: Folks who loved the popular 2003 movie won't be disappointed by the Elf Musical on Broadway. This funny NY musical stays mostly true to the movie, while adding a fun Christmas score and even more classic one-liners.
- Limited Engagement: The Elf Musical is only on Broadway for two months during the holiday season. Catch this new holiday classic on Broadway while you can once it returns this season!
Inside Knowledge: "Buddy the Elf, what's your favorite color?" Don't worry - the Elf Musical leaves all your favorite lines from the movie in tact, and even adds some classic new quotes you'll be repeating all the way through the holidays.
Do's and Don'ts:
- Do Sing Along: As Buddy says in the Elf musical on Broadway,"The Best Way to Spread Christmas cheer is singing loud for all to hear."
- Do Bring the Kids: Kids of all ages will be entertained by the colors, excitement and humor of Elf the Musical.
- Don't Worry if You Haven't Seen the Movie: Even if you didn't catch this new holiday classic on film, you'll have no problem getting in on the jokes of Elf on Broadway.
- Don't Wait to See It: Like any classic holiday show, Elf on Broadway is only available during the months of November and December, so be sure to check back for updates on show dates.


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Wasteland merchant (character)
this wiki
Don't you see? The Great One has gifted us all! It's a second chance!
"The wasteland merchant is a dying man in a random encounter in the Capital Wasteland in 2277. Two other wasteland merchants are found dead in the Deathclaw Sanctuary.
The merchant appears high on some sort of drug, and rambles about the wasteland being alive. He dies as the Lone Wanderer tries to make sense out of him. The wasteland merchant note which can be taken from his corpse explains that he was offered a drink from the strange residents of some "green mountain."
The corpses of two other wasteland merchants are located in the Deathclaw Sanctuary. They can be found in piles of gore and bodies. Both carry a decent ammount of supplies.
Interactions with the player characterEdit
Interactions overviewEdit
General | Services | Quests | ||||||||||||||||||||||
Apparel | Weapon | Other items |
Roving trader outfit Roving trader hat |
.32 pistol | Wasteland merchant note |
- His homestation clearly seems to be Megaton, as he has the lines "Carting his things back to Megaton" as well as "Folks in Megaton won't be needing it anymore". The latter line refers to the town being blown up by the atomic bomb in the town center.
- After the encounter with the living merchant, a marker for Oasis will appear on the Pip-Boy map if it was not already there.
Notable quotesEdit
- "I saw life! Life is returning to the Wastes! The Great One brings it to all of us!"
- "I've seen the ground reaching to the sky with its outstretched arms. The Wasteland is reborn!"
- "Don't you see? The Great One has gifted us all! It's a second chance!"
The wasteland merchant appears only in Fallout 3.


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War Costs Top $1.6 Trillion
Turkish Helicopters Attack Iraqi Villages
Iraq's Kurdistan Govt Denies Strikes by Turkey
US Military Reversing Iraq Troop Surge
Baghdad: A Tale of One City, Now Two
Tuesday: Tuesday: 49 Iraqis Killed, 36 Wounded
US Kills 15 Militants, 3 Civilians in Afghanistan
US Softens Stance on Iran Strikes
Bhutto Put Under House Arrest Again
Is Bhutto-Musharraf Confrontation for Real?
US Envisions a Pakistan Beyond Musharraf
3 Killed in Philippines Parliament Blast
More Viewpoints
US Digs in to Guard Iraq Oil Exports
CBS: Blackwater Notified 'All Immunities Shall Be Canceled'
Judge Slaps White House With Restraining Order
Plame Leaker Blames White House Memo for His 'Foolish' Actions
Fox Host 'Let Down' by Implausibility of Suitcase Nukes
Battle of the Bushes
US: Iraq Insurgent Firepower Declines
Militant Leader in Norway Exile 'Not Sorry for Cameraman's Death' in Iraq
In Mixed Slice of Baghdad, Old Bonds Defy War
More Shi'ite Militia Members Join Army, Police
Hurdles Halt Plans for Shi'ite Militia Recruits
Iraq: Refugees Forced Home as Funds Dry Up
Report: Iraqis Detained in Lebanon
Chertoff: US in Iraq Keeps al-Qaeda Out
Army Iraq Contracts Granted to Sex Partners
Army May Ban Security Firm From Contracts
Syria Hosts Tour to Tout Iraq Border Security
Bulgaria Writes Off 90 Percent of Iraq's Debt
18 Veterans Arrested in Boston Antiwar Protest
Giuliani Campaign Tries to Minimize Fallout From Kerik Indictment
Bush Says US Deaths in Iraq Were Not in Vain
Wife Faces Deportation After Husband Killed in Iraq
State Dept Eschews Probes for Iraq, Afghan Embassy Attacks
Pentagon Eyes Future Space Wars in Budget Request
Hawaii Site Remains Closed After WWII Bomb Found
Overhaul of Military Labs Urged
Justice Dept. Chief Faces a Test in Minnesota
Report: 47 Gitmo-Related Flights Passed Through Spain
EU: Worldwide Rights Under Siege in War on Terror
Panel Decries UN, EU Terrorism Blacklist Process
Aussie Judge Informs Police Muslims Still Have Rights
In Time of Raised Tensions, Moscow Honors Its Cold War Spies
US Embarrassed as Putin Honors Spy Who Came in From the Cornfields
Russian Army Chief: New Arms Deal Must Eliminate Nukes Being Deployed Overseas
Russian Officer Jailed for Beating Conscript to Death
UN Envoy to Quiz Myanmar Junta Leaders
Khmer Rouge Ex-Foreign Minister Arrested
Second N. Ireland Policeman Shot in Week
US Envoy Urges Georgia to Lift Emergency
Congo and Rwanda Agree to Align Against Rebels
Congo Militia Head Lubanga Faces First ICC Trial
Nigeria Makes 'al-Qaeda' Arrests
Brown Warns Iran of Investment Sanctions
Merkel and Sarkozy Agree on Iran Strategy
Iran's President Lashes Out at Nuclear 'Traitors'
Kurdish Separatists Kidnap Seven in Turkey
Poll: Vast Majority of Turkish Kurds Wouldn't Leave for Independent Kurdistan
US Fights for Boost in NATO Troops in Afghanistan
New Zealand Defense Chief's Nephew Killed in Afghanistan
Amnesty: NATO Afghan Detainees Face Torture Risk
US to Send Special Envoy to Confront Musharraf
Bhutto to Defy Ban, March
Sharif: Dictatorship Can End if All Parties Boycott Elections
Pakistani Party Slams Harassment of Activists
40 Peaceful Protesters Held for Denouncing Pakistan's State of Emergency
Commonwealth Threatens to Suspend Pakistan
Musharraf Makeover Proves Too Much for One Lobby Firm
Indian Officials 'Want a Stable Pakistan'
Pakistani Army Troops on Offensive in Troubled Swat Valley
US Agrees Not to Put Its Logo on Projects in Pakistan Tribal Area
Barak: Israel Needs Its Own Peace Plan to Foil Arab One
Netanyahu Meets With Rabbi to Coordinate Opposition to Peace Talks
Palestinians, Israelis Resume Talks but Clash Over 'Jewishness'
Peres: Israel, Palestinians Can Make Peace
US and Israel Play Down Hopes for Peace Talks
Israeli Soldier Launches Missile Near Lebanese Border by Mistake
Fatah Supporters Fear Arrest After Arafat Clashes
Israeli Troops Detain Two Hamas MPs
Israeli High Court Wonders How Bedridden, Dying Gazan Poses Security Threat
In the West Bank, Militants Wanted by Israel Often Feel Unwanted
Lebanon Ruling Coalition Blasts Hezbollah Over Presidency
Beirut's Empty Stadium Full of Ominous Implications
Report: US to Provide Lebanon Trainer Jets
Jordanian Women Register Heavily for Elections
Human Rights Activists Condemn Religious Discrimination in Egypt
Somalia's War Flares Up Again
Somali Journalists Facing Daily Abuse
Search for Weapons Heightens Mogadishu Woes
Residents Flee Mogadishu as Government Battles Rebels


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(35 quotes found)
"It's a bit of a carrot-and-stick strategy. The carrot is to produce industry-accepted solutions that enterprises want to deploy. The stick is that the carriers are in agreement on these practices and will be checking to see that the vendors are in compliance."
Andrew Moran
"We want to offer developers a carrot rather than beat them with a stick."
Alan Isaacson
"Try chewing carrots, it's crunchy"
sotonye anga
"That's part of the carrot you put out with communities as you're closing a plant."
Alan Baum


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The Mio Cyclo 105 is your ideal everyday training companion which lets yourself improve your performance with the personal workout partner. Also comes supplied with a built-in ANT Plus sensor, a wireless HR monitor and Barfly Out Front handlebar mount.
MTB: | Yes |
Power Plug Type: | USB |
Multi-sport: | No |
Bluetooth Enabled: | No |
GPS: | Yes |
Vibration Alert: | No |
Heart Rate Monitor Compatible: | Yes (Included) |
Barometric Altimeter: | No |
Time/Distance alert: | No |
Touchscreen: | No |
Ant+ Compatible: | Yes |
Colour Display: | No |
Backlight: | Yes |
Cadence Compatible: | Yes |
EU Plug Supplied: | No |
US Plug Supplied: | No |
Aus/Nz Plug Supplied: | No |
Road: | Yes |
The device records your time, speed, distance, height, calorie consumption and your tracks with the built-in GPS. So when you get home, you can easily analyse your recorded tracks, and share your experiences online via the Mio Share desktop application. Mio Share is also your one-stop shop for managing your device and finding out the latest product information or software updates.
The Mio Cyclo 105 H is equipped with a built-in ANT+ sensor, and has a wireless heart-rate monitor included.
The Barfly Ou Front handlebar mount allows you to have your Mio computer mounted right at the front of your bike allowing perfect vision.
GPS receivers are now made waterproof, lightweight and small enough to fit on a bike easily. There are 2 basic choices to take on your bike: a GPS unit designed primarily for navigation with a dedicated bike mount, particularly suitable for cycle touring and finding your way in unfamiliar territory, like the Garmin eTrex Vista Cx; or a dedicated bike computer that uses GPS to track your training routes and provide detailed analysis of your workout like the Edge 305, with more limited navigation capabilities. Most units come with only very basic maps installed and you may need to purchase more detailed maps for your area to be loaded onto the unit for navigation.
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Mio have become one of the leading players in the mobile GPS industry, bringing mobility, navigation, and quality to an ever-growing audience all over the world. Mio's brand tag line, "Explore More", focuses on changing the way people experience the world and lets users know that they can explore the world easily and freely.
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Executive Director: Will Kernan.


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Phrased very well by BLDGBLOG as a possible scenario and usage of Sebastien Wierinck's public furniture: "After a long day at work, then, you would walk into your house – which has no permanent furniture – and you'd see a shimmering mass of black tubes swaying in a slight evening breeze above your head…You'd push several buttons, and the system would begin to move, drooping down in long loops and turning back and forth in tight corners and curves, all laying out the forms of temporary furniture – bed, table – as you get ready for a quiet night at home." I love the photo documentation- each set of furniture seems to have its own mood.
Tag Archives: Public spaces
Eastside Angelinos are probably familiar with the dead-end leading to an overpass in Chinatown on Yale Street (I know I've made the repeated mistake? miraculous discovery? of turning onto Yale and thinking it was a through street many a times)- but less have probably seen it used for anything not related to shady drug deals (can anyone confirm this assumption?).
Get Rid of White Walls Collective is focused on bringing fine art out of galleries and into non-traditional spaces: public, domestic, industrial, nautical, etc. These events are meant to reveal the unique identity of these sites to the surrounding public, offering a place of public interaction via the provocation of the urban landscape.


text:
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DonateO?Grady was born on February 14, 1922 and passed away on Tuesday, April 20, 2010.
O?Grady was a resident of West Point, Virginia at the time of his passing.
O�Grady served in the United States Navy during WWII, from 1942 until 1946 when he received an Honorable discharge. He held the rank of MoMM2c.
He was married to Ann.
A memorial service will be held at West Point United Methodist Church, 2 p.m., Friday, April 23rd.
In lieu of flowers, contributions can be made to the West Point Volunteer Fire Department and Rescue Squad, P.O. Box X, West Point, Va., 23181, or to West Point United Methodist Church, P.O. Box 610, West Point, Va., 23181.


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The Herbal Lore of Wise Women and Wortcunners
- Artikel-Nr.: BOOk1
- Freitextfeld 1: Medien > Bücher
Traditional herbalists or wise women were not only good botanists or pharmacologists; they were also shamanic practitioners and keepers of occult knowledge about the powerful properties of plants. Traveling back to the healing arts of the ancient Egyptians, Greeks, and Romans, The Herbal Lore of Wise Women and Wortcunners takes readers deep into this world, through the leechcraft of heathen society and witches' herb bundles to the cloister gardens of the Middle Ages. It also examines herbal medicine today in the traditional Chinese apothecary, the Indian ayurvedic system, homeopathy, and Native American medicine.
Balancing the mystical with the practical, author Wolf Storl explains how to become an herbalist, from collecting material to distilling and administering medicines. He includes authoritative advice on herb gardening, as well as a holistic inventory of plants used for purposes both benign and malign, from herbs for cooking, healing, beauty, and body care to psychedelic plants, witches' salves for opening alternative realities, and poisonous herbs that can induce madness or cause death. Storl also describes traditional "women's plants" and their uses: dyeing cloth, spinning and weaving, or whipping up love potions. The Herbal Lore of Wise Women and Wortcunners is written for professional and amateur herbalists as well as gardeners, urban homesteaders, and plantspeople interested in these rich ancient traditions.
"A deep excursion into the heart of herbalism … The Herbal Lore of Wise Women and Wortcunners invites us into the hearts and essences of the plants and encourages us to discover 'who' they are through the realm of our own senses." —from the foreword by Rosemary Gladstar, author of Rosemary Gladstar's Herbal Recipes for Vibrant Health and coauthor of The Herbalist's Way
"For the serious student of herb lore, or anyone who would be delighted by the colorful history of herbalism … Wolf Dieter Storl has penned an account of wortcunning that is entertaining and practical. Without sacrificing pragmatic information about the healing properties of plants, Storl reveals the amazing mystique of this ancient lore."
—Matthew Wood, author of The Earthwise Herbal
"A thorough history of global plant medicine that incorporates intellect, science, and lore … an insightful reference that needs to be part of every herbalist's library."
—Kris Hill, herbalist and founder of Hillbotanical.com
"I own at least a couple of hundred books on all aspects of herbs and herbalism, but this one is my all-time favorite. Not so much a book about herbs, but a literary walk down the secret garden path to the plant devas themselves. I have learned more about the art and craft of traditional herbalism from these pages than from any other source, and I am delighted that this book is now, finally, becoming available to the English speaking world! A 'must read' for any student of herbalism who wants to go beyond formulas and constituents."
—Kat Morgenstern, founder of ethnobotany and ecotravel website SacredEarth.com
"[The book] discusses old European, Oriental, and Native American herbal medicine with all of their mysticism and in the same breath speaks about modern concepts of health. The reader is taken into a historic world that accepted and used herbal energetics in healing. The text delves into principles of shamanism, homeopathy, planetary influences, and anthroposophic medicine. … Comparisons of Chinese, Ayurvedic, and Greek classifications of medical plants according to taste and smell is particularly interesting."
—Kathi Keville, American Herb Association
"[Wolf D. Storl] provides enough detail to empower the novice while surprising the old hand. … I recommend this book to any practicing herbalist and serious researcher who seeks a source of literature previously lacking in our discipline."
—Amanda McQuade Crawford, consultant medical herbalist at The Ojai Center of Phytotherapy and contributing editor to HerbalGram
"The Herbal Lore of Wise Women and Wortcunners offers a survey of the healing art of ancient Egyptians, Greeks and Romans and contrasts these early practices with herbal medicine today from Chinese, Indian and Native American medicine. Author Wolf D. Storl explains how to collect plants, distill, and administer medicines from them and includes old-world 'women's plants' and their other uses as well. … A fine acquisition for any interested in herbalism and botany."
—Midwest Book Review
North Atlantic Books (17. Januar 2012)
Taschenbuch, 392 Seiten
Sprache: Englisch


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If [14x / root(2x+2)], what is one possible value of x?
14x / root(2x+2) is a term not an equation!
I don't know how to figure it out..
The answer to this was 1/2
Well, one possible value is x= 0! A more interesting question is "what are all the possible values of x.
That's true, but irrelevant. This problem did say anything about "solving an equation".14x / root(2x+2) is a term not an equation!
No, an answer was 1/2. If x= 1/2 then which is a perfectly good result. x can be 1/2. If x= 0, as I gave before, thenI don't know how to figure it out..
The answer to this was 1/2
which is also a valid answer. Or x= 1000000 (for no paticular reason) then which is again a perfectly good result. There are, literally, an infinite number of possible answers to this problem.
(But not all numbers. For example, if x= -1, that denominator becomes and you cannot divide by 0. If x= -2, you have , not a real number.)


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Women Making Films - India is a not-for-profit community that strives to provide a platform for female filmmakers globally, to network, collaborate and create works of audio-visual medium.
Read more -
Roya Film House (RFH) was founded in 2003 by Roya and Alka Sadat to fill the void of the Afghanistan filmmaking system after the fall of the Taliban regime. RFH is a professionally managed independent Afghan film company, one of the largest production companies in Afghanistan.
Read more -
Arab Woman Platform was put together by women just like you, in search of something more substantial with a focus on matters that everyday women can relate to.
Read more -
Viddsee is a media and technology company that distributes and markets short movies through community-driven networks. Viddsee streams curated short movies via its Viddsee.com web-based video platform.
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Her Film Project
Her Film Project is a global initiative to support women and girls behind the camera, on screen, and behind the scenes, and to encourage film inclusion in all its forms.
Read more -
The Los Angeles Film School
The art of storytelling has evolved, and today the only limit to the movies, games, and media we make is our imagination. The Los Angeles Film School (LAFS) is committed to providing the best possible education to storytellers looking to start their careers creating animation, film, video games and audio.
Read more -
The Domari Society
The Domari Society of Gypsies in Jerusalem supports the Domari, who are one of the minorities in Jerusalem and in the West Bank. The Domari Society of Gypsies in Jerusalem was founded in 2000 and the Community Center opened in 2005. The Domari Community Center aims at empowering individuals, with a focus on women and children by providing literacy courses and school supplies for the poor as well as offering after-school tutoring.
Read more -
Honor Diaries
Honor Diaries is a film focused on women's rights and gender inequality in honor-based societies. Through the voices of some of the world's leading women's rights activists, the film demonstrates the depth of human rights abuses women face. Honor Diaries is more than just a movie: it's a movement to ensure that women's voices - no matter the religion or background - are heard. Culture is no excuse for abuse.
WADI – Stop FGM Middle East & Asia Campaign


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Posted by theladyzman on Oct. 05, 2006
Learn everything you need to know about how to become royalty!
Hey Break fans! Check out our latest compilation - Crazy People in Public!
Go-Go back to your childhood and revisit the teenagers with attitude that w...
Posted by theladyzman on Oct. 05, 2006


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littlemissmimi » Dom Damien Dom Damien: Welcome to the Farm Sir, if you have questions, i am here to help, enjoy your time here
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Annapurna Pictures beat out its rivals in a bidding war to option Rooney Mara project "A House in the Sky." The New York Times bestselling memoir is written by Amanda Lindhout and Sara Corbett. Mara will star and serve as a producer alongside Annapurna's Megan Ellison. Annapurna's Chelsea Barnard will oversee the day-to-day development and production of the project.
It's easy to see why Mara ("The Girl with the Dragon Tattoo"), would be attracted to the harrowing story of how Amanda Lindhout, who loved exploring the world's most remote and perilous places, was abducted in 2008 by a rebel terrorist group in Mogadishu, Somalia. Her memoir recounts her 15 months chained and starved and abused in captivity. The book was brought to Mara's attention by her team at Management 360 who then approached Annapurna.
Mara recently wrapped Todd Hayne's "Carol," starring opposite Cate Blanchett, an adaptation of the Patricia Highsmith romance novel "The Price of Salt." Mara is now playing Tiger Lily in "Pan," Joe Wright's take on "Peter Pan."
Annapurna Pictures' 2013 projects "American Hustle," "Her" and "The Grandmaster"earned 17 Academy Award nominations, making Ellison the first woman to earn two Best Picture nominations in the same year. Annapurna also backed Kathryn Bigelow's "Zero Dark Thirty" and Paul Thomas Anderson's "The Master." Coming up: Cannes hit "Foxcatcher," development of "Hunger Games" producer Nina Jacobson's adaptation of "Where'd You Go, Bernadette?", written by Maria Semple, and Denver & Delilah and CJ Entertainment's remake of "Sympathy for Vengeance," written by William Monahan and starring Charlize Theron. Annapurna is also producing a television project on the intersecting lives of Greta Garbo and Marlene Dietrich with writers Angela Robinson and Alex Kondracke.


text:
Fantastic Flat with River Views (3)
Vendégek száma4
Hálószobák száma1
Méret50 m²
Floor No.3(with elevator)
- Erkély/terasz
- Törölköző
- Családi / Gyerek barát
- Konyha
- Légkondicionálás
- Internet/WiFi
- Lift az épületben
Accommodation summary
Cím | Rua Cova da Moura, 1350-116 Lisboa Lisbon, Portugália |
Ingatlan típusa | Apartman |
Ingatlan azonosító | U0LJDIWT |
Acceptance rate | 99% |
Response time | A few hours |
Calendar updated | Today |
Equipped with a sofa bed for two persons, one single sofa and an extra bed allows up to 4 guests. Decorated tastefully, is five minutes walking distance from transports covering the entire river side and 10 minutes away from the city historic centre giving those who visit Lisbon a great means of locomotion. Bathtub with a very low ceiling.
-Check-in is after 3:00 p.m. and is made directly in the apartment, but please call, or send a message, to our representative after collecting your luggage at the Lisbon airport, or train/bus station, to let us know you are already in Lisbon. Our representative will give you a friendly welcome and answer the questions you may have.-You should leave the apartment until 11:00 in the morning.
-Check-in after 23:00 is subject to a 25 EUR fee.
-We will provide you with our contact details after your reservation is confirmed.
-The apartment will be ready and cleaned for you before your arrival. Fresh towels and bed clothing are also provided and all is included in the total price. You will be given a set of towels per person.
-Keys delivery: In the apartment
-Cleaning: On departure
Árak |
Ár >2 vendégre | 5 € /fő/éj extra |
Részletek |
Érkezés legkorábbi időpontja | 15:00 |
Check-in before | rugalmas |
Távozás legkésőbbi időpontja | 11:00 |
Lemondási feltétel |
A házigazda egyéb ingatlanjainak értékelései
Our host was awesome, he met us at the agreed time , the apartment was as described/ photographed. I would highly recommend a Stay as all issues we had were addressed promptly and without delay . Thanks for making our vacation memorable, see you again soon in the near future.
Very friendly, good accomadation - best result!
The flat is good situated in Barrio Alto, near to the historical tram number 28. We had a friendly welcome and a good time in Lisboa. The room is very small for two persons, on the foto it looks bigger. Andrea & Jürgen
We had a lovely stay, the apartment is well furnished and perfectly located for young travelers, close to the train station. If you are traveling during the summer, you'll find it cool and comfortable.
On the downside, not so many kitchen supplies; high humidity -I guess this comes for all Lisbon- and we had to give a 100€ deposit in cash at our arrival, which we didn't know about..., but we got it back quickly by bank transfer.
This apartment is right in the middle of Alfama where I personally enjoyed very much with the old buildings and good atmosphere in the area. The apartment was clean and very well furnished, particularly with a iPhone speaker provided in the living room (which is perfect for young travelers). Costa was extremely nice although we did not have the chance to meet him in person. The only thing I would like to raise is that the apartment is quite humid and it is one of the drawbacks of living close to the river in general (not only Costa's flat) I suppose. Both my boyfriend and I are easily prone to nasal allergies in humid environment, so it was the only thing we found uncomfortable during the stay.
Nice stay in this clean and cute studio in a atypical neighbourhood! I recommend it! However it is not made for two adults, it would clearly be too tight! Very calm in itself (main noises from the tramway n°28, but this is completely acceptable)
Everything is available: towels, bed sheets, wifi, kitchen, washing machine.. When I decided to rent the studio longer than expected, there was no problem and Antonio's friend was helping. By the way, he is a nice host, ready to help at any time! The only issue maybe was about the 100 Euro deposit I had to pay extra, which was not mentioned on the website when I rented the flat and I only heard about it when I arrived in the room in Lisbon. I got it back of course at the end of my stay, but it took some days.. and I had to write some more texts to get the transaction done. This could be improved. Otherwise, a very good stay!!
Everything was great: location, appartment and welcome. We had a lovely stay, i'd recommend this appartment to friends & family
It was a Great Apartment, clean and good Equipment in the kitchen, but we thought it was a Little Too small for two Person
We stayed in Costa's appartment for a couple of days and we really enjoyed it. It's well located in the oldest district of Lisbon (Alfama). The apartment is lovely decorated (their eye for detail is amazing) and convenient with a nice big kitchen (including dishwasher). It's really clean and silent (apart from the neighbours upstairs who you could hear walking around but that isn't too much of a burden). You can easily contact them. We were delayed and Antonio was waiting for us till after midnight. He was really kind and despite of the hour kindly explained us the must see's in Lisbon. We would definitely recommend this place!
It was really nice to visit Lisbon and stay in this apartment. This cozy and good located place was a nice spot to rest after all day sightseeing.
- Minőségbiztosított szállás
- Minden házigazda hitelesítésre került telefonon keresztül
- Biztonságos fizetés SSL titkosításon keresztül


text:
What's new?
Achilles tendon
Acne treatment
Alzheimer drugs
Alzheimer's procedures
Alzheimer's alternative
AMD (age-related macular
degeneration) of the eye
Antibiotics new
Antibody therapies
Anti-Cancer antibodies
Anti-clotting drugs
Arthritis drugs
Arthritis procedure
Artificial Organs
Artificial heart
Artificial liver
Artificial lung
Artificial pancreas
Asthma procedures
Asthma drugs
Atrial fibrillation
Batten disease in children
Bladder cancer
Blood pressure medicine
Blood clotting inhibitor
Blood clotting procedures
Blood pressure
Blood clotting promoter
Bone building
Bone cancer
Bowel cancer
Brain Surgery
Brain aneurysm
Brain Cancer Drugs
Brain Cancer Procedures
Brain Cooling in emergencies
Brain injury
Brain stents
Brain cancer vaccines
Brain cancer radiotherapy
Breast cancer Drugs
Breast cancer procedures
Breast cancer vaccine
Cancer drugs
Cancer prevention:
Cancer radiation therapy
Cancer treatment
Cancer vaccines
Carotid stenting
Catheter therapy
C. difficile
Celebrity illnesses
Celiac diseas
Cerebral palsy
Cervical cancer vaccines
Cystic Fibrosis
Cluster headaches
Colon cancer surgery
Colorectal cancer drugs
Colorectal cancer alternative
Cosmetic surgery
Cosmetic surgery alternatives
Crohn's disease
Diabetes drugs and devices
Diabetes procedures
Emergency medicine
Esophageal Cancer
Eye treatment
Fibroids, uterine
Flesh-eating disease
Gastrointestinal stromal
Gaucher disease
Graft versus Host disease
Gut infection
Hair loss treatment after
cancer chemo
Head and neck cancer drugs
Head and neck cancer
Health insurance innovation
Heart valve replacement and
Heart pumps
Heart Atrial Fibrillation
Heart pacemakers
Heart procedures
Heart stem cell trials
Heart treatment alternative
Hepatitis C Drugs
HIFU (High Intensity Focused
Hip repair
HIV drugs
Huntington's disease
Immune system boosters and
Implantable Defibrillator
Implantable infusion pump
Kidney dialysis
Kidney cancer drugs
Kidney cancer vaccines
Kidney procedures
Knee repair procedures
Laser Spine Surgery
LED (Light Emitting Diode)
Light Therapy
Light activated therapy
Liver Cancer procedures
Liver cancer drugs
Liver cancer radiotherapy
Liver problem alternative
Lou Gehrig disease
Lung Cancer procedures
Lung Cancer Drugs
Lung cancer vaccines
Lung cancer radiotherapy
Lyme disease
Medical tourism
Melanoma (deadliest type of
skin cancer)
Mitral Valve Replacement
Multiple Myeloma
Multiple Sclerosis
Muscular dystrophy
Neuroblastoma, a rare cancer
in children
Opinion Page
Ovarian Cancer Vaccine
Ovarian Cancer procedures
Ovarian cancer drugs
Ovary transplant
Pain medication
Pain treatment
Pain treatment alternative
Pancreas cancer radiotherapy
Pancreatic cancer procedures
Pancreatic cancer drugs
Peripheral Arterial Disease
Photodynamic therapy (PDT)
Pregnancy prevention
Preterm babies
Prostate Cancer
Prostate cancer alternative
Prostate cancer drugs
Prostate cancer vaccines
Prostate cancer radiotherapy
Prostate benign (hyperplasia
Pulmonary valve implants
Radiation sickness
Regenerative medicine
Robotic surgery
Sexually Transmitted
Sickle Cell
Skin cancer
Skin cosmetics
Skin cancer vaccines
Spinal surgery
Spinal procedures
Spine Cancer
Spine cancer radiotherapy
Sports medicine
Stem Cells Treatment using
patient's own cells
Stem cell treatment eye
Stent for Peripheral Arterial
Stroke treatment
Stroke drugs immediate
Stroke drugs
Tennis elbow
Testicular cancer
Uterine fibroids
Varicose vein
Varicose vein alternative
Veterinary innovations
Weight loss surgeries
Wound care
As things stand today, for most
medications, only a small
portion reaches the organ to be
One of the challenges of the
drug industry is to increase that
portion, particularly inside the
In traditional drug delivery
systems such as oral ingestion
or intravascular injection, the
medication is distributed
throughout the body through
the blood circulation.
Targeted drug delivery seeks to
concentrate the medication in
the tissues of interest while
reducing the relative
concentration of the medication
in the remaining tissues.
This new technique punches
holes in cells, and it could treat
In the early 1970s it was
reported that the application to
cells of very fast electrical
pulses - in the microsecond and
millisecond range - creates an
electrical field that causes
nanoscale pores to open in the
cell membrane. This is called
Research since then has mainly
focused on reversible
electroporation, which uses
voltages low enough to
temporarily increase the cell
membrane's permeability. The
holes in the cell membrane
created by reversible
electroporation close up shortly
after treatment, allowing the cell
to survive.
This concept has really caught
on in modern biotechnology,
especially over the last decade.
It is used primarily to help get
genes and drugs into cells.
The field of irreversible
electroporation was pretty much
Irreversible electroporation
(IRE) uses electrical pulses that
are slightly longer and stronger
than reversible electroporation.
With IRE, the holes in the cell
membrane do not reseal,
causing the cell to lose its ability
to maintain homeostasis and die.
In a way IRE overcomes the
limitations of current minimally
invasive surgical techniques
that use extreme heat, such as
hyperthermia or radiofrequency,
or extreme cold, such as
cryosurgery, to destroy cells.
Advocates of these modern
techniques claim that they focus
on the cancerous part and
nothing bad happens to the
sorrounding tissue.
This is not entirely true.
Temperature damage to cells
also causes structural damage
to proteins and the surrounding
connective tissue. For liver
cancer, the bile duct is at risk for
damage. For prostate cancer,
the urethra and surrounding
nerve tissue is often affected.
Electroporation, on the other
hand, acts just on the cell
membrane, leaving collagen
fibers and other vascular tissue
structures intact. Leaving the
tissue's "scaffolding" in place
allows healthy cells to regrow
far more quickly than if
everything in the region was
Another chronic drawback of
heat or cryo treatments for
cancer is the difficulty in treating
cells that are immediately
adjacent to the blood vessels.
Because blood maintains a
relatively stable temperature, it
actually transfers heat or cold
away from a treatment area in an
attempt to return the region to a
normal temperature range. That
means some cancerous cells
might actually survive treatment.
That counts for a lot of failures
when treating liver cancers.
With IRE, you can destroy
cancerous cells right next to the
blood vessels. It's a more
complete treatment. In clinical
practice this is about as good as
it gets.
To commercialize this
technology, Drs Rubinsky and
Onik founded Oncobionic which
was later sold to
AngioDynamics, a New York-
based manufacturer of medical
The FDA granted approval to
market irreversible
electroporation technology for
soft tissue ablation, which uses
needles and image guidance to
target cells. The process is
similar to existing thermal
ablation technologies, but
instead of "cooking" or
"freezing" the targeted tissue, it
disrupts the cell membrane,
thereby destroying the targeted
The impaired cells are then left
in the body to be removed by
the immune system.
AngioDynamics calls their
technique the "NanoKnife
System" as the next generation
in minimally-invasive tissue
ablation technology.
The NanoKnife System includes
an energy generator, footswitch
and single-use disposable
electrodes. The System uses
electrode probes to transmit
active energy from its generator
to a targeted area.
During treatment, the unique
action opens permanent nano-
sized pores in the cell
membrane, causing irreversible
damage which rapidly induces a
natural cell death. After IRE
treatment, cells that form the
nerves, blood vessels, and
other collagenous tissues in the
treated area remain viable,
reducing the risk of damage to
these structures. Microscopic
imaging after treatment reveals
a sharply delineated separation
between affected and
unaffected cells.
Inovio is another company
who's electroporation-based
DNA delivery system can
increase the cellular uptake of
an agent by 1,000 times or more.
When used to deliver DNA
vaccines, Inovio's systems can
increase levels of gene
expression (i.e. production of
the coded protein) by 100 times
or more compared to plasmid
DNA delivered without other
delivery enhancements.
There are hundreds of
thousands of proteins in the
human body, many of them with
links to human disease.
However, only a tiny fraction —
about 20 percent — of these
proteins is considered
"The entire pharmaceutical
industry has been working on
drug-design platforms that
focus on this little sliver of
human drug targets and this
limits the drug arsenal available
to doctors," says Gregory
Verdine, Ph.D, a chemical
biologist at Harvard University.
"What's required is an entirely
new class of drugs that
overcome the shortcomings of
drugs of the past."
Thanks to a new generation of
drug discovery technologies,
that tiny fraction is now
After decades of dreaming the
drug developer's impossible
dream, scientists finally are
making drugs that target the
"untouchables": the hundreds
of thousands of proteins
against which previous efforts
had failed to develop a drug.
Peptide molecular medicine is a
very hot area.
So-called "stapled peptides,"
get their name from chemical
"braces" that hold the peptides,
or protein fragments, in a
compact shape that gives them
high stability in comparison to
their unfolded versions.
The three-dimensional shape is
critical for the peptide to
function normally and help
orchestrate body processes.
The chemical stapling allows
them to resist destruction by
The Swiss pharmaceutical giant
Roche is throwing its weight
behind the experimental
technology of Aileron
Roche has agreed to pay $25
million now and up to $1.1
billion later to Aileron
Therapeutics of Cambridge,
Mass., for developing the
"stapled peptides" technology.
Aileron, which holds patent
rights from Harvard and the
Dana-Farber Cancer Institute,
hopes to start clinical trials in
Synthetic peptides can deliver
particularly potent doses of
drugs at the cellular level. They
are stabilized in a helical shape
that stays active longer in the
body. They have been
successfully tested in animals.
In human trials they are
planning to deliver medicine
inside cells for a variety of
medical conditions, including
Roche's priorities like
treatments for cancer and
Professor DiMarchi co-founded
Marcadia Biotech in 2005 and
signed a licensing deal with
Merck in 2008 to pursue other
forms of stabilized peptides to
treat diabetes and obesity.
Such new technologies are
fraught with possible setbacks,
however, on the path from
laboratory bench to bedside.
Monoclonal antibodies, for
instance, another hyped field a
few years beack, have yet to
live up to expectations.
Scientists from ANU ( Australian
National University) have
developed a 'Superbowl' drug
delivery system that promises
more accurate drug dose
The researchers, led by
Associate Professor Michael
Sherburn, have created a
molecule which can capture,
hold and deliver drugs.
"Excitingly, unlike conventional
capsules, we can control the
rate at which a drug is released
from our superbowl container
molecule," said Sherburn. "This
has the potential to allow lower
drug doses, hence leading to
fewer side-effects."
The group have already
successfully put aspirin inside
the superbowl and are now
working on incorporating drugs
to treat other diseases,
including cancers, arthritis and
heart disease.
University of Purdue developed
a patch that can painlessly
deliver drugs to a patient's
bloodstream with the touch of a
Babak Ziaie, a professor of
electrical and computer
engineering, and his research
team have fabricated a "patch"
composed of a new type of
pump and an array of
The patch is powered by liquid
fluorocarbon, a substance
similar to those used in
refrigerators, that has very low
boiling point. The user simply
places his or her finger on the
pump, which causes the liquid
to rise in temperature and boil.
This reaction activates the
pump which puts enough
pressure on the medication to
force it through the skin.
It all takes about 30 seconds.
The drug is delivered through
microneedles at the bottom of
the patch which barely
penetrates the skin. The patch
contains an array of needles,
each about one-fourth the width
of a human hair. Applying the
patch feels like rough paper.
Most medications have
molecules that are too large to
be absorbed through the skin.
This technology could allow
easier distribution of medication
like painkillers, hormones,
insulin and cancer treatments.
Ziaie and his team created the
patch to be practical and
disposable. The idea is that it
will be used once and thrown
away. All components used to
make it are fairly common and
can be manufactured easily and
Nano-particle technology
enables drugs to be made into
very tiny particles so they are
able to be readily delivered to
the site of action. Generally this
enables a higher dose to be
delivered without compromising
safety and tolerability.
ABRAXANE ( a cancer drug)
trials showed that nab
technology allowed for a 49%
higher dose of paclitaxel to be
delivered, significantly
improving efficacy compared to
conventional solvent-based
Nab technology is Abraxis
BioScience's proprietary
nanoparticle technique which
leverages albumin
nanoparticles for the active and
targeted delivery of
chemotherapeutics to the
tumor. This nab-driven
chemotherapy provides a new
paradigm for penetrating the
blood-stroma barrier to reach
the tumor cell.
The company said: "We believe
ABRAXANE exploits the
albumin-binding protein
receptor, Gp60, to penetrate the
blood-stroma barrier in essence
opening a portal to the tumor
micro-environment, enabling the
delivery of targeted cytotoxic
agents leading to stromal
collapse and tumor penetration."
Nanodiamonds Show Promise
As Safe Chemo Boosters For
Breast And Liver Cancer
Finding ways to make
chemotherapy drugs more
efficient is a continual
challenge, particularly for the
treatment of cancers that are
resistant to chemotherapy, such
as recurring breast and liver
One way to do this, is through
the use of nanoparticles to
deliver the drugs. One example
that researchers have been
looking at recently is the
nanodiamond, a particle of
carbon that is between 2 and 8
microns thick; about 10,000
times thinner than a human hair.
The advantage of using such
tiny particles is that you can get
the drug to stick to their
surfaces, use them to enter
cancerous cells and release the
drug slowly over time, exit the
cell when they are finished, then
leave the body altogether.
Using nanodiamonds, tiny
particles of carbon, as a drug
delivery system, researchers
have developed a promising
approach to treating breast and
liver cancer tumors that are
resistant to chemotherapy.
Led by Dr Dean Ho, an
associate professor of
biomedical engineering at
Northwestern University in
Evanston, Illinois, US, the
researchers used lab mice to
test how effectively and safely
the nanodiamonds released the
cancer drugs over time.
Ho told the press that in this
study, they were able to boost
the efficiency of the cancer drug
they tested 70 times while still
maintaining safety.
"It's the best of both worlds," he
If you could see a nanodiamond
you would understand why it
has that name, it looks like a
diamond, and it is not just its
size that makes it useful, but
also its shape.
"They're called truncated
octahedrons," explained Ho.
"They're shaped like a soccer
ball but the faces are more
It's the faces of the
nanodiamonds that allow the
drugs to bind tightly to their
surface and release slowly.
Ho said sustained release was
an important feature because by
their very nature, chemotherapy
drugs are toxic.
Sustained release over time also
reduces side effects of very
toxic chemotherapies.
"The surface chemistry,
coupled with the architecture of
the surface, allows for a very
sustained interaction with
drugs," said Ho.
The drugs can be bound tightly
to the surface with a chemical
bond, or temporarily with an
electrostatic bond. It is useful to
have these options because
some drugs can do their job
without letting go of the surface,
while others have to come away
to be effective.
Another advantage of
nanoparticles as drug delivery
systems is that you can make
them seek out particular
molecules or tumor sites by
attaching a unique chemical
compound or antibody to one
For this study, Ho and
colleagues tested the
nanodiamonds as a delivery
system for doxorubicin, a
common chemotherapy drug
that is very efficient at killing
cancer cells but as Ho
explained, "it is also very
effective at killing everything
"Just as all roads lead to Rome,
all roads lead to cellular
delivery," says Steven F.
Dowdy, Howard Hughes
Medical Institute investigator."
Today, everybody in the field
recognizes that delivery is the
problem to solve, and all other
problems, of which there will be
numerous ones, pale in
Scientists trying to deliver
siRNA need to engineer around
several troublesome properties.
RNA has a molecular weight
that is 10 to 20 times that of a
traditional small-molecule drug.
And because the molecule is
highly negatively charged, it
typically can't cross the similarly
negatively charged plasma
membranes to enter the cell.
Delivery systems for siRNA
must overcome three major
obstacles: getting the drug to its
target in the body, coaxing it
inside the cell, and releasing it.
Even after all that is
accomplished,companies still
need to worry about safety, a
major concern given the power
of siRNA to turn off cellular
Lipid- and polymer-based
systems are the most
established approaches for
systemic delivery of RNAi.
In the clinic, lipid nanoparticles
(LNPs) have advanced the most.
Alnylam Pharmaceuticals,
widely acknowledged as the
leader in the RNAi arena, has a
liver cancer drug in Phase I
trials that applies Tekmira
Pharmaceuticals' stable nucleic
acid lipid particle technology.
Delcath Systems Inc expects to
apply for U.S. review of its
cancer drug delivery system in
the fourth quarter of 2010, which
would put it on track for
approval by mid-2011.
Delcath in June 2010 presented
trial results showing that
melanoma patients whose
cancer had spread to their liver
survived for an average of 398
days before dying or having
their cancer get worse after
treatment with the company's
"Percutaneous Hepatic
Perfusion" system.
Patients treated with standard
drugs survived for an average
of 124 days before they died or
their tumor growth restarted.
Delcath's system is designed to
deliver high doses of the
generic chemotherapy drug
melphalan directly to the liver
via the hepatic artery.
The system aims to minimize
side effects by filtering the
highly toxic drug out of the
blood stream as it leaves the
liver, but some of the drug leaks
Two of the 93 patients in the
pivotal trial died as a result of
the treatment. A third death was
attributed to the fact that the
patient had such advanced liver
metastases that he should not
have been enrolled in the trial.
Delcath's pivotal trial, in which
patients were allowed to cross
over from standard treatment to
the Delcath system, was
designed in concert with the
He estimated that around 15,000
U.S. melanoma patients would
be eligible for treatment with the
Delcath system.
Delcath is also studying use of
the system in other types of
In September 2010 the New York
Times ran a dramatic story
concerning melanoma.
Two young men, friends, both
had it. One managed to get into
a clinical trial of a promising
drug, PLX4032 made by Roche,
the other one , due to the
random nature of the trials, was
The man in the trial survived, the
other died.
Some of the doctors involved,
according to the story, bitterly
complained about the system:
that if a drug is promising early
on, why do they have to wait for
years to prove survival
advantage and not give it to all
neeedy patients right away.
Well, the story has several
It does not mention some
innovating ideas in trial design
in the works. And it does not
mention that there are several
locations where the trial of this
drug is not random, not to
mention several other trials
ongoing against the same BRAF
There are currently 13 non-
randomized trials for BRAF-
mutant, advanced melanoma
listed in the National Cancer
Institute's clinical trials
database. These are phase I and
II trials, with either PLX4032 (the
drug in the Times story) or for
GlaxoSmithKline's version of
the drug, and they are actively
recruiting patients with
advanced disease; previous
treatment is okay for most of
Aside from that there are
approved treatments that have
shown reasonable success in
cell culture assays such as
Melphalan, Interleukin-2,
ImuVert [Serratia marcescens
microscomes], Interferon,
Temsirolimus + Bevacizumab.
And because they use "real
life" 3D analysis, that kind of
profiling predicts of what willl
happen in the body.
It is called "functional profiling
analysis", which is measuring
biological signals rather than
DNA indicators, and it will
continue to play an important
role in cancer drug selection.
Primary tumors are different for
every patient.
Real-time assessment is already
used in newly designed
BATTLE and I-SPY clinical trials.
The functional profiling
approach involves real-time
assessment of "fresh" living
cancer tissue and endothelial
cell behaviors in the presence
or absence of anti-cancer or anti-
angiogenic drugs. This method
accounts not only for the
existence of genes and proteins
but also for their functionality
and for their interaction with
other genes, other proteins, and
other processes occurring
within the cell.
Patients would certainly have a
better chance of success had
their cancer been "chemo-
sensitive" rather than "chemo-
resistant". Identifying the most
effective chemotherapy would
be more likely to improve
These new trials are using the
so-called adaptive trial design.
The University of Texas M. D.
Anderson Cancer Center runs
the BATTLE for lung cancer.
The study uses an innovative
statistical model to match four
drugs to specific molecular
signatures, or biomarkers, in the
tumors of 255 stage IV non-
small cell lung cancer patients
who had received between one
and nine previous treatments.
Lung cancer is the number one
cause of cancer death in men
and women, but huge
randomized trials involving
thousands of patients have
either failed completely or
shown negligible survival
Until recently, chemotherapy for
lung cancer has been given on
a one-treatment-fits-all basis.
The BATTLE trial, shows that
treatments tailored for each
patient's particular type of lung
cancer may improve outcomes.
Biopsies of the patients' tumors
are analyzed for mutations in
four different pathways that
affect growth of tumor cells.
Then 255 patients are randomly
assigned to take one of four
different drugs specifically
targeting the pathways.
The four drugs: erlotinib
(Tarceva), sorafenib (Nexavar),
vandetanib (Zactima) and
bexarotene (Targretin). To date
only erlotinib has been
approved by the FDA for use
against lung cancer.
Overall, 46 percent of patients
had their disease in check after
eight weeks of treatment,
meaning that their tumors had
not grown significantly or had
That compares with 30 percent
of late-stage lung cancer
patients with controlled disease
after eight weeks on traditional
Each drug was found to do best
against tumors associated with
specific types of mutations.
For instance, sorafenib was
effective for 61 percent of
people who had mutations in
the KRAS gene, but people who
had mutations in the EGFR gene
actually had a worse outcome.
Based on these promising
results, sorafenib in particular is
worthy of further study.
Erlotinib worked best against
tumors with EGFR mutations,
while vandetanib was most
effective for people who had
high levels of VEGFR-2 protein
in their tumors.
A combination of erlotinib and
bexarotene was most effective
for people with defects in the
Cyclin D1 pathway or who had
extra copies of the EGFR gene
in their tumor cells.
BATTLE has set a precedent for
future clinical trials with the goal
of identifying biomarkers early
on and improving the chance of
successful treatment. This
biological knowledge will shift
the paradigm of how future trials
are done.
Another trial called I-SPY 2 is
unusual because it is
"adaptive," meaning that it uses
information from one set of trial
participants to make changes in
the study for future participants
as it moves forward.
Only drugs that show promise
pass into later stages of the
study, and less-successful
candidates are dropped and not
available for future trial
The trial design is expected to
greatly speed the process by
which new drugs are tested and
approved for use by cancer
Stem Cell
Heating Up
Of the mere 15 publicly traded
biotechnology companies
currently developing stem cell
therapies [see Table 1], more
than half of them have
competing programs in three
major disease areas:
•Central nervous system [CNS]
Accordingly, the purpose of this
article is to review the key
players in each of these
segments and contrast their
different approaches.


text:
James Taylor Adds Second Red Rocks Show June 18–Get Your Pre-Sale Code Here!
"You've Got A Friend"; "Carolina On My Mind", "Everyday", "Sweet Baby James".. The list goes on and on. To see James Taylor in concert is like witnessing America's music history -in person. To see James Taylor at Red Rocks is a must-see event!
TRI-102.5 has your chance at buying tickets for the June 18th show BEFORE they go on sale to the general public!
Get your promo code!
James Taylor has made America smile for decades. A great voice matched with great songs. He will be bringing both to Red Rock on June 17th and NOW- June 18th as well. These will be the LAST TWO shows of his U.S. tour!
TRI-102.5 wants you to be at the show! Courtesy of Live Nation, we have your chance to purchase tickets for that LAST SHOW- June 18th- before they go on sale to the general public on March 17th!
On Friday March 14th, from 10am to 10pm you can follow THIS LINK TO PURCHASE TICKETS using the PROMO/OFFER CODE—- "ACCESS"
Have fun at the show—and THANKS for listening to
The Best Variety of Lite Rock Favorites!


text:
signs, signs
a weekly meme of interesting, funny, ridiculous and unexplainable signs
FREE BADGE, help yourself!
About Me
View my complete profile
Wednesday, March 22, 2017
fat food
very mixed reviews online. doesn't really look like a place I'd want to eat at,
but the sign is interesting.
Wednesday, March 15, 2017
a Toronto streetcar
506 Carlton
travels from Main Street subway station
along Gerrard St to Carlton St which changes name to College St
and ends at High Park
then turns around for the 15 km (9 miles)
back to Main Street
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text:
PS3 / XBOX 360 / PC | Japan |
By Spencer . January 28, 2013 . 2:02am
Namco Bandai took photos inside FromSoftware where the team is working on Dark Souls II. These pictures give us a peek at some weapons, armor, and perhaps a familiar character.
See the artwork for the character with a crown on the white screen?
It kind of reminds me of Gwyn from Dark Souls.
Any guesses here?


text:
Betty granted no other interviews, but she had grown to trust me.
In one of the biggest "gets" of the book, Cohan interviews Robert Steel, who was the chairman of Dukes?
Robert Wright interviews me on BloggingheadsTV about my new book, Patriots.
interviews in the studio are not one-on-one affairs typically but with all three co-anchors together.
This sentiment was echoed in interviews Tuesday with three other veterans of the magazine.
His prices for these interviews worked out, as a rule, at about three cents a word.
In all these interviews Violet's name has not been mentioned.
She was calm and impersonal during these interviews, and he tried to be so.
But how shall we fix the time and place for these interviews?'
I know what I am; at the end of a couple of interviews I shall rebel, and become wicked.
1510s, "face-to-face meeting, formal conference," from Middle French entrevue, verbal noun from s'entrevoir "to see each other, visit each other briefly, have a glimpse of," from entre- "between" (see inter-) + Old French voir "to see" (from Latin videre; see vision). Modern French interview is from English. Journalistic sense is first attested 1869 in American English.
The 'interview,' as at present managed, is generally the joint product of some humbug of a hack politician and another humbug of a newspaper reporter. ["The Nation," Jan. 28, 1869]
"to have a personal meeting," 1540s, from interview (n.). Related: Interviewed; interviewing.
An object-oriented toolkit developed at Stanford University for building graphical user interfaces. It is implemented in C++ and provides a library of objects and a set of protocols for composing them.


text:
SACRAMENTO, Calif. (AP) -- The state's political watchdog is reviewing votes by Sacramento County Supervisor Susan Peters to determine whether she violated California law by approving projects at an airfield near property she owns.
The Sacramento Bee reported Tuesday (http://bit.ly/1oYcjcb) that Peters has voted for dozens of improvements at Mather Field despite having an ownership interest in two office buildings and land at the former air base.
Gary Winuk of the Fair Political Practices Commission tells the newspaper the agency should decide within a week whether to open a formal investigation of Peters.
She faces a civil fine of up to $5,000 for each violation if regulators determine she has violated the Political Reform Act.
Peters tells the Bee that she has followed the law and will not vote on any Mather airport issues in the future.
Information from: The Sacramento Bee, http://www.sacbee.com


text:
Thermaltake Spedo Advance Case Review (DE) The Thermaltake Spedo Advance is the next PC Case in the Technic3D Editorship. See you in the following Review which qualities and Features the Gaming Tower from Thermaltake presents. Better with Cable Routing Management, Advance Thermal Chamber, Support up to 8 fans and side 23cm fan? http://www.technic3d.com/article-788...do-advance.htm |
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text: You can also check out the fifth Podcast with director Toby Wilkins inside. Now playing on Ultra HDNet Video on Demand is Magnet Releasing's Splinter (review), which also hits theaters on October 31st. To promote the special showing for subscribers, a new five-minute promo was released that not only goes behind-the-scenes, but also features brand new footage from the film that follows a young couple who retreat to the wilderness for a romantic camping weekend-but the trip quickly spirals into a nightmare when they are car-jacked by an escaped convict and his girlfriend. Thrown together by chance, no one can imagine the terrifying horror that awaits the two couples at a remote and isolated gas station. Check it out over at BDTV, click the title for more info on the film.Watch SPLINTER now on Time Warner, Cox, Comcast, AT&T, Brighthouse, Cablevision, Charter or Verizon FIOS