text:
Veteran's Administration Education Benefit Programs
Chapter 30 – Active Duty Military- All Volunteer Force. Must receive Honorable discharge and contributed $1,200.00 to the G.I. Bill
Chapter 31 – VA Vocational Rehabilitation – Must have VA Medical Rating of 20% disability or greater
Chapter 32 – VEAP program – Post Vietnam Era - Must have contributed money to education benefit program that was matched by Government
Chapter 33 – Post 9/11 G.I. Bill – Must have at least 90 days Active Duty service after 9/11/2001
Chapter 35 – Survivors and Dependents – Parent or Spouse deceased or rated 100% disabled due to permanent and service- related disability
Chapter 1606 – Selected Reserve & National Guard – Must be actively drilling member
Chapter 1607 – REAP (Reserve & Guard) - Must have at least 90 days Active Duty service (not including training) after 9/11/2001.
For more information on eligibility requirements contact the Department of Veterans Affairs at www.gibill.va.gov
To apply for or continue your VA educational benefits under the G.I. Bill, contact the UCO VA office. Phone (405)974-2578 or email at firstname.lastname@example.com.


text:
The Register includes buildings, places of worship, monuments, parks and gardens, conservation areas, battlefields and wreck sites that are listed and have been assessed and found to be at risk. Of all listed buildings across England we assess:
Grade II listed buildings outside London, other than places of worship, are not included.
Download a regional register for additional information about this year's findings and what is being done to reduce risks in your area.
What determines whether a site is included in the Register? Find out more about the criteria we use.
An explanation of the terms and abbreviations used in the Heritage at Risk Register.
The National Heritage List for England (NHLE) is the only official and up-to-date database of all listed and designated heritage sites.
Find out where and how you can search for buildings at risk which are for sale.
Download spatial data for the Heritage at Risk Register
Process for submitting a request for a change to the HAR Register
© Historic England 2017

subset: commoncrawl


text:
Skip to main content
Where pulmonary hypertension is concerned, knowledge is power. Pulmonary Hypertension Association can help.
If you are a medical professional, PHA has resources to offer.
Updated July 2015
*NOT approved for PH except in New Zealand; used when no other IV option is available(1) Available but not approved specifically for PH(2) Available on an individualized patient basis by physician request(3) Approved but not marketed or not commercially launched
For optimal viewing of PHAssociation.org, please use a standards-compliant browser such as Google Chrome or Firefox.
The information provided on the PHA website is provided for general information only. It is not intended as legal, medical or other professional advice, and should not be relied upon as a substitute for consultations with qualified professionals who are familiar with your individual needs. PHA does not endorse or recommend any commercial products or services.
801 Roeder Road, Ste. 1000, Silver Spring, MD 20910 Patient-to-Patient Support Line: firstname.lastname@example.com Privacy Policy Terms of Use Provide Feedback & Report Bugs
Designed by Matrix Group International, Inc.® | © 2017 Pulmonary Hypertension Association. All Rights Reserved.
The National Organization for Rare Disorders (NORD) awarded PHA the Abbey S. Meyers Leadership Award in 2012 for outstanding service to PHA members in advocacy, education and other key areas.


text:
Healthcare Speakers Bureau
At Bon Secours Charity Health System, we are committed to the health and well-being of the community we serve. We understand that education and information are key elements in keeping our community healthy in many ways. Our speakers welcome opportunities to share their knowledge and experience.
what is the purpose of the Healthcare Speakers Bureau?
The purpose is to provide the community with educational and informational speakers to address health-related topics and trends as well as aid in improving the overall health status of residents. As we experience rapid advances in medical technology and changes in the delivery of high quality care, we recognize our role in the community as not only providers of care but educators as well. The Healthcare Speakers Bureau is a great resource for bringing medical expertise and education programs to your group or organization.
who is involved?
Our physicians, nurses, therapists and hospital professionals are available to speak to any civic groups, service clubs, school organizations and businesses on a wide range of topics.
what is the cost?
There is no charge for a guest lecturer to speak at your meeting or event.
speaker requests
Please submit your at least 4 weeks prior to your event. We will do our very best to accommodate your schedule.
Contact Barbara Demundo, BSCHS Community Outreach Director: 845-368-5545


text:
Thanksgiving is a day to remember that we have so much to be thankful for. I can imagine the first thanksgiving celebration in the colonies. How much those people must have enjoyed the day knowing they had a bountiful harvest, that they were relatively safe, that they could practice their religious beliefs in a new land without persecution.
Lately I have become very interested in my heritage. I have spent time learning more about my family and where they came from and who they were. Fortunately my Dad has done a lot of research on this and is passing it on. This week we discovered something we had not known about our family. We are American Germans from Russia (that we knew). What we did not know was that in the late '30's and early '40's the Russians rounded up the Germans living in Russia and sent them to Siberia and other "Internment Camps". We uncovered via the Internet a full listing of the people from the Village of Norka, where my family came from, that were sent to the camps. In that list we found 6 members of our family, direct descendents. We saw that they were all brutally killed in the camps in 1942. For refusing not to denounce their faith and because they were German.
This Thanksgiving, I am thankful that I have the opportunity to be here and to be part of my family.
Happy Thanksgiving…. and Happy Scouting!


text:
Recently at the 2012 National Stationery Show, we dedicated one of our storefront windows (prime real estate!) to QR Codes and how to incorporate them into social stationery. Wedding invitations, letterhead, business cards: Why yes, there is a way to include one and still keep that classic aesthetic & craftsmanship Crane & Co. is known for.
In case you're curious how to do so, we've put together this handy QR Code Etiquette Guide. Technology never looked so luxurious.
Have more questions about stationery etiquette & style? Email our Crane Concierge at email@example.com.


text:
Web Stories
Map shows campus voting districts, polling stations for Aug. 13 special primary election for U.S. Senate
Posted August 1, 2013; 10:43 a.m.
Residents of the Princeton University campus can view an online map to find the location of their voting districts and polling stations for the Aug. 13 special primary election for the New Jersey U.S. Senate seat formerly held by Sen. Frank Lautenberg. Polls will be open from 6 a.m. to 8 p.m.
For this special election, two polling locations have temporarily moved. Residents of Butler Apartments, in District No. 19, will vote in the Computer Science Building. Residents of Stanworth Apartments, in District No. 9, will vote in the Municipal Building located at 400 Witherspoon St.
Made available by the Offices of Community and Regional Affairs and the Dean of Undergraduate Students, the map shows the voting districts, as well as the location of the polling stations in each.
All students should bring their Princeton University ID card for identification.
Additional voting information for New Jersey residents is available on the New Jersey Division of Elections website.


text:
PHILIPSTOWN TREE SERVICE: Land clearing, take downs, trimmings. Stump Removal. Fully insured. Reg. No. PC 607. 845- 265-2187.
NR MASONRY LLC: New homes, additions, all types stonework - patios, entrance pillars, fireplaces, walls, curbing, Unilock. Brickwork, stucco, repairs. PC Lic #373, 914-527-1287
MASSAGE: Feel Good Again! Georgia Christy, Licensed Massage Therapist. 424-4224.
YOUR BEAUTIFUL HOME by Toland Construction. Renovation, restoration, remodeling and new construction. All size jobs. PC#1244 and insured. 845-265-2253
HONOR THY PLUMBER Villanova Plumbing & Heating. Masters of the fine art of plumbing and heating for over 25 years. Repairs, new installations including radiant & HW heat. No job too small. Call 845-528-3158 anytime
MELLON ELECTRIC Residential - Commercial. New homes & additions. Service upgrades & generators. No job too small. PC#4409 845-446-2579 Bob
TOO BUSY TO CLEAN? Let me help. Excellent service, long term local references, reliable, insured, English speaking, Products supplied. Elizabeth 845-590-7146
paint/plaster repair 28 years experience. Free estimates. Call George Kimmel. 845-831-8723
expert spring cleanIng by European woman available for home or office. Local Ref's. Please Call Tatiana 845-549-0992
crystal clear window cleaning service ... Residential Specialist. Since 1995. Specializing in all windows. All shapes and sizes. Free estimates. Fully insured. Year round service. 845-431-6967
GARRISON TREE, INC. Tree takedowns, pruning, landclearing, cabling, chipping, firewood. Landscape design, planting, plant health care, stump grinding, mulch. Consultations available. Joshua R. Maddocks, certified arborist cert. # NY 5332A. Fully Insured. Reg. No. PC2213-A Please Call: 845-265-3434
TRANSPORTATION AW Limousine. Affordable rides in luxurious Towncars to all airports & NYC. Professional courteous drivers. 1-866-304-LIMO (5466)
les oil / DOWNEY OIL 90 Years of Warm Service. Now Authorized Buderus Dealer. Visit our Web Site:DowneyOilNY.com 845-265-3663
KIMMEL Construction Honest, Reliable, Top quality workmanship. Complete renovations, kitchens, baths, decks, trim. All phases of carpentry & building. Pls view our website kimmelbuilders.com 845-656-4956 Lic# PC941
j&c landscaping, inc Specialist in lawn maintenance, spring clean ups. Fertilizing, edging, planting trees & shrubs. All types of masonry work & repair. Lic/Ins. Free spring clean up with 2013 Contract. PC#3196-A 914- 941-8146 or 914-490-8260
Computer Services. Your personal Help Desk. We come to you, or drop off. Locally based in Putnam, Microsoft Certified Professional. Courteous, prompt, professional. In business for 20 years. Home and Business needs. Security, Virus, Backup, Disaster Recovery, Upgrades. Wi-Fi, Smartphones, Mac and PC. Visa, MC, Amex and Disc.cards accepted! 845-284-2390. John.
rolfing Naomi Canaan, Board Certified Practitioner www.rolfguild.org 845-728-2580
paint/plaster repair 28 years experience. Free estimates. Call George Kimmel. 845-831-8723
pruning, planting Weeding. Stone and brick pointing, NYBG Cert. in Landscape Design 10 years local experience. Estate work. Call Gregory 845.446.7465
Expert Gardening/ Grounds keeping. Weekly/ bi wkly. lawn maintenance, spring cleanups. Organic lawn & tree fertilization programs. Tree service. create-a-scape.us 845-424-2323
Brad Teasdale, Massage Therapy.Licensed Massage Therapist for American Ballet Theater & Broadway Stars / Garrison Office. Outcalls Available 917.362.7546 firstname.lastname@example.com
CREATIVE CHILDCARE – Energetic Grandma w/degree in Recreation. Warm, reliable, local. Loves pets, too! 265-5295.
simply elegant Simply the Best. Full service salon in downtown Cold Spring Nails, Hair, Waxing - Treat yourself today! 845-265-1032


text:
By Avi Salzman
St. Jude Medical (STJ) fell 5% on Monday, representing the biggest decline among stocks in the S&P 500, as the company battled negative reports about one of its products.
St. Jude demanded that a medical journal retract a recent article about the company's Riata defibrillator leads, which connect defibrillators to the heart. The article, in the journal HeartRhythm, said the leads have a high rate of failure, according to Reuters. But St. Jude said the analysis was biased and contained errors. The news about the journal article has been around for a few days, but St. Jude's response may have once again spooked investors.
St. Jude's announced last week that it would stop selling certain other leads.
That said, some analysts have urged caution.
"We suspect ICD lead concerns will remain on the table, or in investors' and physicians' minds, regarding the stock (potentially increasing volatility) and the company's reputational profile in general. However, we believe STJ can work through the issues, continue to take share, and deliver on its pipeline," BMO Capital Markets analyst Joanne Wuensch wrote last week.


text:
Asian night! Time to bring out the chopsticks for delicious noodles, pork and veggies.
Bok choy is a mild, versatile vegetable that resembles a bunch of wide-stalked celery with long, dark green leaves.
Whole wheat pasta has three times the fiber of regular pasta.
Use 1 cup sliced celery for the bok choy.
© 2017 ®/TM General Mills All Rights Reserved


text:
- 3 years ago by Jill O'Rourke
- 17 Comments »
- Share a Tip
The other day we told you all about IMDb's parental guides for movies, and we shared some of our favorite excerpts from classic kids' movie guides. But what about movies that actually are inappropriate for children? R-rated movies with sex and violence and F-bombs left and right? More


text:
Your chosen Date or Name engraved into a natural stone pebble, with a Date or Name on the other side…its up to you! Perfect for celebrating christenings, weddings, anniversaries and birthdays.
Engraved text - maximum of 10 characters on grey, 7 on white or 8 if a date. Dates are converted to numbers eg: 15th August 2011 will be 15.08.11 ("Characters" are letters, spaces and punctuation eg: M.J. & F.S. is 11 characters and too long!) All letters are engraved as capitals.
GREY - warm plum-grey hues / WHITE - off-white chalky hues (there will be variations in colour, markings and shape as this is a natural stone product)
Gift box - A stylish white gift box is available, tied with ribbon. For discounts on large orders, see our Engraved Family Stones.
Please note:
The pebbles are not man-made. They are natural stones smoothed flat on river beds and may contain imperfections e.g. chips, fissures and cracks, mottling, colour blemishes and fine grey thread lines (the white shows up more flaws than the grey and come in a range of shapes). Stones will vary in size, shade, shape and texture; if you order two stones they will not match. We have taken a rough, organic product and left it in its natural state, engraving the type like a stamp in the stone. We hope you'll appreciate the uniqueness of these natural stones, and treasure them as a personalised keepsake.
Grey - length range between 8-12cm. White - length range between 6-7cm. See other listings for larger pebbles with more engraving.
|How long will your order take?
|Production time
|This item takes up to 7-10 days to make.
|Delivery times after production
|Standard Delivery
|After production, item posted tracked Royal Mail - £2.75, 2-3 days
|After production, item posted tracked Royal Mail - Europe (2-5 days), US (5-10 days), Worldwide (5-14 days) - By weight (calculated at checkout)
|Not available for this item


text:
Friday Afternoon
Trip Start Apr 07, 2006
1Trip End Apr 09, 2006
Map your own trip!
Loading Map
Loading Map
Map Options
Show trip route
Hide lines
Friday night we watched Dana Brown's great documentary, "Dust To Glory". The next night we had some killer steaks while viewing "I Walk The Line".
We made two new trails that were pretty challenging at first, but after a few attempts, I was able to ride them fairly consistently. Then it was time to try riding in the reverse direction. That turned out to be pretty tough the first time. Then I figured out where the front wheel needed to be.
Right before the photos were taken Saturday afternoon, I got too close to a tree that had some old barbed wire wrapped around it and tore the right sleeve on my shirt. It's visible in the photographs. I somehow avoided getting even the smallest scratch on my arm. I bet I couldn't do that again! So I removed the offending wire to make sure.
All photographs by Sander J. Avant


text:
The Agua Caliente Indians were industrious and creative with a reputation for independence, integrity, and peace. They believed this productive land of their ancestors would always be theirs. However in 1876, the U.S. Federal Government deeded in trust to the Agua Caliente people 32,000 acres for their homeland. At the same time, they gave the So. California Railroad ten miles of odd sections of land to induce them to build the railroad. Of the reservation's 32,000 acres, some 6,700 lie within the Palm Springs city limits. The remaining sections fan out accross the desert and mountains in a checkerboard pattern.
As early as the 1890's, Palm Springs and the surrounding area have been described as a recreation oasis. Tahquitz Canyon and three southern canyons are listed in the National Register of Historic Places. Palm Canyon is considered the world's largest California Fan Palm Oasis.


text: Kansas City based comic David Naster is still performing stand up in comedy clubs coast to coast and on some of the world's finest cruise ships. But increasingly, he is in hot demand as a healthcare speaker. David Naster is considered an authority on the healing power of humor. He's written several books on the subject, including You Just Have To Laugh. Now he has produced a new documentary that is currently making the rounds on the film festival circuit.


text:
Have you ever purchased from PartSelect.com before?
Thank you for helping make our site better.
Below is a list of all parts for the Kenmore Refrigerator 10641512100. To find the repair part you need, you can browse the list below or you can narrow your choices by searching for a part by name or description.
This drawer does not include the white handle trim any longer.
Used with Evaporator Fan Motors.
This metallic screw is less than an inch long and comes with a plastic washer.
This part is located in the back of the freezer, and circulates air over the refrigerator coils. These coils will convert the heat into cool air, which is then circulated. Fan blad...
This part controls the light.
This screw is sold individually.
For white, biscuit, black and stainless models.
Sold individually.
This part screws into the side of the wall in your fresh food compartment and supports a shelf.
The bulb is sold separately.
All brand logos are trademarks of their respective owners.
The PartSelect logo is a Registered Trademark of Atlantic Laundry Centres, Ltd.
Copyright © 1999-2017 , Eldis Group Partnership. All rights reserved.


text:
- KCII Radio - http://kciiradio.com -
Housing Rehabilitation Assistance Deadline
Posted By News On @ 6:28 am In Today's Local News | Comments Disabled
View Larger Map [1]
The city of Washington has been awarded federal funds for housing and rehabilitation assistance. City Administrator Dave Plyman says the city was awarded funds by the state and Federal governments to assist six homeowners with home repairs. He says the requirements are you have to live in the home for which you are seeking the funds, own or purchasing the home, fall at or below the federal housing income guidelines, and live in the target area.
Plyman says the target area runs from D Avenue to 3rd Avenue and from 5th Street to 9th Street. He says homeowners that qualify will receive $25,000 as a forgivable loan as long as the homeowner remains in the home for five years. Applications are due tomorrow and to find out more information regarding this assistance, you can contact Washington City Hall.
No related posts.
Article printed from KCII Radio: http://kciiradio.com
URL to article: http://kciiradio.com/2011/02/housing-rehabilitation-assistance-deadline/
URLs in this post:
[1] View Larger Map: http://maps.google.com/maps?f=d&source=embed&saddr=W+5th+St&daddr=E+5th+St+to:N+3rd+Ave+to:E+7th+St+to:Unknown+road+to:Unknown+road+to:N+2nd+Ave+to:W+9th+St+to:N+Marion+Ave+to:W+8th+St+to:N+C+Ave+to:W+7th+St+to:N+D+Ave&hl=en&geocode=FQQ9dgIdFNKI-g%3BFdw8dgIdGu-I-g%3BFfhDdgIdOO-I-g%3BFe5DdgId6uyI-g%3BFUBHdgIdkuyI-g%3BFVRHdgIdfuqI-g%3BFYhKdgIdiOqI-g%3BFZJKdgIdTOCI-g%3BFTJIdgIdKOCI-g%3BFURIdgId9taI-g%3BFR5EdgId9taI-g%3BFSpEdgIdbtKI-g%3BFQQ9dgIdFNKI-g&mra=mi&mrcr=11&mrsp=12&sz=16&sll=41.305569,-91.691186&sspn=0.006528,0.019205&ie=UTF8&ll=41.305569,-91.691186&spn=0.006528,0.019205&t=h
[2] Image: http://www.printfriendly.com/print?url=http://kciiradio.com/2011/02/housing-rehabilitation-assistance-deadline/
Click here to print.
Copyright © 2005-2013 KCII Radio


text:
Description & Highlights
For a clean, attractive looking countertop microwave, the Oster .7 Cu Ft Stainless Steel Microwave Oven (OGG3701) is a great choice. The stainless steel cabinet and front door with mirror glass nicely complements your kitchen's other stainless steel appliances. This fully featured microwave provides up to 700 watts of cooking power and a 0.7 cubic foot capacity, ideal for dorm rooms, apartments, and small offices. 10 adjustable power levels give you flexibility, and 6 auto-cook/one-touch menu functions make common tasks easy - choose from potato, popcorn, pizza, beverage, frozen dinner, and reheat modes.
This microwave also lets you defrost by weight. A removable glass turntable helps foods cook more evenly. The microwave also features a digital clock and timer with an LED display, a white interior cavity, and a cook end signal.
Stainless Steel:Stainless steel appliances look great in contemporary kitchens and they're easy to clean in the event of spills
Compact Size:This 0.7 cubic foot microwave is perfect for dorm rooms, small apartment kitchens, and small offices - anyplace where space is at a premium
Plentiful Power:With 700 watts of power, this microwave can easily handle most microwave tasks
- Model: OGG3701Oster .7 Cu Ft Stainless Steel Microwave Oven
- Brand: OsterWhite cavity
- 10 adjustable power levelsRemovable glass turntable
- 6 Auto-cook/1-touch menu programsCook end signal
- Express cookingStainless steel
- Weight defrostInput voltage: 120V / 60Hz
- LED displayPower: 700W
- Digital timer and clockWeight: 23.15 lbs
- 0.7 cu. ft. capacityDimensions: 10.32" H x 17.8" W x 14.06" D
- Warranty: 1 year
- Height: 10.32"
- Width: 17.8"
- Depth: 14.06"


text:
Salmon is one of the easiest and most delicious fish to cook on the grill. By paying attention to a few minor details, you can…
Stainless Steel 32 Quart Pot w/ Rack
Description & Highlights
Bayou Classic Stainless Steel 32 Quart Pot w/ Rack - Stainless Steel
Cook or fry just about anything with the Bayou Classic Stainless Steel 32 Quart Pot w/ Rack (1118POT). This fryer pot is perfect for frying turkeys, boiling crawfish, and just about anything you can think of to cook in it! At 32 quarts, this pot can hold and cook just about anything no matter the size, and its commercial grade stainless steel construction makes this fryer extremely durable. The perforated basket and poultry rack make frying or boiling easy without the hassle of taking the food out of the water or accidentally burning your hands.
The accessories included with this pot help you make the best food imaginable. The poultry rack and grab hook lets you easily check on your chickens of turkeys to see how they are cooking, allowing them to roast to perfection to get that succulent flavor. A stainless steel turkey fryer thermometer enables you to check the temperature of your bird to make sure it is cooked thoroughly, while the included 1 ounce trial seasoning injector allows you to inject your favorite food with some of the best seasons and spices you can put into it. All of these accessories help to make this pot one of the best values on the market, and you'll be sure to enjoy yours for years to come.
Durable:Made out of commercial-grade stainless steel, this pot is perfect for any cooking job that requires durability and strength
Safe:With the steam/boil basket and poultry rack, you won't have to plunge your hand into hot water to retrieve your food - just remove the rack or basket and you'll have it ready to go!
Dishwasher Safe:The pot and all of its stainless steel accessories (except the injector) are dishwasher safe and easy to clean
- Model: 1118POTBayou Classic Stainless Steel 32 Quart Pot w/ Rack
- Brand: Bayou Classic1 oz trial seasoning injector
- Capacity: 32 quartsThree (3) piece chicken skewer set
- Stock pot: 0.6 mm/22 gauge12" stainless steel thermometer
- Vented lidThermometer range: 50-750 degrees F
- Perforated steam/boil basketCommercial grade stainless steel
- Perforated poultry rackDishwasher safe
- Stainless steel grab hookWeight: 12.22 lbs
- Made in: ChinaDimensions: 17.5" H x 12" W x 12" D
- Warranty: 1 year
- Height: 17.5"
- Width: 12"
- Depth: 12"


text:
Rocketfish Mobile - Earbud Headphones - Black
"Rocketfish is the Best Buy house brand of audio components/accessories. When I picked these up I was getting sick of the 'pinched' sound of my CX300ii series B, or whatever name Sennheiser has attached to them. By 'pinched' I mean boosted in the wrong places of the spectrum. I don't believe in spending $500 on iems that are going to be sweated on, tossed in a gym bag and otherwise abused. Hell..." --Mach-X
Rocketfish Mobile Stereo Ear Bud Headphones Black RF-MEP2
Enjoy your favorite tunes with these ear bud headphones that feature a neodymium magnet and 10mm drivers for great audio quality. What's Included * RocketfishTM Mobile Stereo Ear Bud Headphones * Ear buds (small, medium, large)
BudClipz (TM) Earbud Keeper
Fits iPod and iPhone earbuds (those included in the original Apple retail packaging). Simply snaps into place on your earbuds. Fits most BlackBerry® and other manufacturers' standard earbuds. Always keeps your earbuds available at shoulder height. One Year Limited Warranty


text:
By Tiernan Ray
Piper Jaffray's Gus Richard today reiterates an Underperform rating on shares of Intel (INTC), and a $20 price target, writing that the company "keeps investing in fabs and process technology that is likely to result in diminishing returns, in our view."
Richard's first point of concern is the article this morning by Jessica Lessin, Lorraine Luk, and Juro Osawa stating that Apple (AAPL) has signed a long-rumored chip deal with Taiwan Semiconductor Manufacturing (TSM) to move some production away from Apple's chip supplier and arch-rival, Samsung Electronics (005930KS):
Taiwan Semiconductor and Apple have reportedly signed a three year foundry agreement for 20nm, 16nm and 10nm. We believe it is now unlikely for INTC to get any of Apple's business in CY14 or CY15 and in a best case scenario only some of the business in CY16. We estimate Apple's mobile processor business is a $5-6B/year. We also think it is highly unlikely for Samsung to broadly adopt Intel's CPUs in its smartphones or tablets. We think this shuts the door on the high-end mobile market for Intel for the foreseeable future. We believe this also limits Intel's ability to drive mobile and foundry revenue over the next two years.
Interestingly, Richard actually notes Taiwan Semi has stumbled in some of its production efforts:
Even though TSMC has signed Apple, it continues to fail to execute. It has been reported in the press that the Apple/TSMC deal was delayed due to power issues. Our contacts have confirmed the power consumption issues at TSMC at 20nm. This is on the heels of missteps at 40nm, 32nm and failure to meet customer demand at 28nm last year. We believe 16nm is unlikely to be in production at TSMC next year. While TSMC is not catching up with Intel, we do not think they are losing ground. TSMC remains a fast follower.
Despite Intel's lead in chip technology, Richard actually thinks TSM, IBM and others pose a credible threat, in part because Intel doesn't have the right intellectual property to fill the fabs:
We expect Intel to ship 14nm product at the end of this year. Right behind Intel is Samsung who is working on its first FinFET process and we expect Samsung to start shipping 14nm in CY14. Behind Samsung and Intel are TSMC, STMicroelectronics and IBM. Surprisingly, IBM and STM look to have surprisingly strong process technology at 14nm. IBM has a FinFET transistor built on Fully-Depleted Silicon on Insulator (FD-SOI) and STM continues to work on FD-SOI. We believe the IBM and STM processes provide low power and very good analog performance. While Intel remains in the lead in process geometry, we do not believe they have a lead in the SoC designs needed for the mobile era. Intel needs to drive either foundry or mobile revenue to fill its fabs in a stagnant PC environment […] We are seeing a resurgence in IBM's foundry activity. We believe the company recently signed a licensing deal with ARMH for its 32-bit processor line for ASIC customers. Moreover, our contacts are telling us that they are making customer visits promoting their 14nm process.


text:
Latest Headlines
2010 Cincinnati Bengals Preview- Linebackers
Posted on 11 Aug 2010 by Adrian Fedkiw.
The Bengals linebackers have youth and promise. There is one thing that I'm really curious about, and that's what they plan to do with Michael Johnson. Johnson is a guy with talent and needs to see the field. The Bengals have moved him around; whether he's putting his hand on the ground as a defensive end or standing up as an outside linebacker. Currently on the depth chart, Cincinnat...


text:
Tech Tip: Mitigating "git clone"'s inability to be resumed using rsync
Happy new civil year, everyone. As you may know Git is a distributed version control system, but its often time-consuming (if the repository's history is large) "git clone" operation cannot be resumed, which is a problem with bad Internet connections. There was a service that did "git clone" and then allowed people to download using HTTPS Called "Git bundler" but it has been down for sometime now. However, I found a different solution to the problem.
What can be done is use
to log in to a remote host, where the "git clone" is performed (preferably,
but not absolutely necessarily, when running on top of a session of
GNU Screen or
similar). After that, you can use
rsync over ssh to download
the .git directory to the local workstation (I like to use
the invocation
rsync -a --progress -v --inplace for that).
Following that all you have to do is run git clone to a different directory
to the one where you put the
.git and set "git remote" appropriately.
Hope that helps, and the same can be done with other distributed version control systems such as Mercurial, or Bzr.


text: hey canadians... just thought id start a thread here to see how many ontarians we have on here..ive been hunting here since re introduction and have seen the population boom obviously...just wondering how all you guys are doin with your hunts up here and how you plan on baggin a bird this fall..has anyone ever hunted the fall hunt in the states..are you gonna shoot a hen? need any tips on fall calling? lets get this ontario group goin..


text:
Where Are They Now?
Thirty-five local icons and how they made history
By Hannah Kiddoo and Brennan Nardi
For what boils down to an essential snapshot of our city every month, we pack a lot into every issue of Madison Magazine. That's the first thing we discovered all over again when we went paging through past issues, reminiscing about this story or that, in preparation for our thirty-fifth anniversary.
We delve into controversies—remember Monona Terrace and the caucus scandals? We take readers into the heads of entrepreneurs, governors and playwrights. We pay attention to education in Madison classrooms. We cover design in homes, civic buildings and businesses. And breakthroughs in biotechnology, glass ceilings and addiction treatment.
For thirty-five years, our pages have reflected the myriad cultural changes, the exploding population growth in the city and the suburbs, and the companies and institutions—changing or venerable or struggling to reinvent themselves.
Most of all, though, we have written about the people who have influenced Madison through the years. Madison Magazine covered the rise of women and people of color into leadership roles in civic organizations, businesses and government. More than a dozen issues devoted a swath of pages to the people who were trying to make Madison lakes cleaner, healthier and more appealing. We reported on University of Wisconsin–Madison students and leaders, on its past and future, on its sports teams and the geniuses who brought scientific breakthroughs to the world from campus labs and the University Research Park. And we touted the brilliant academics and innovators at Edgewood College, Madison College, high schools and pre-schools.
We featured profiles of smart business owners and devoted community organizers. Writers, artists, doctors, yoga teachers, scientists, famous actors, triathletes, musicians passing through town on tour, ambitious politicians—these folks and many others ended up on our pages.
While some of our issues contained harrowing tales of unsolved murders, and others reflected the panic that came with AIDS, our archives are also a record of all that was sublime, once upon a time, in Madison. One of our first issues, heaven help us, contained a feature on "the local disco scene." Not long after, we reported on the emergence of big, blocky home computers and how everyone was rushing to buy them. We opined on nudity in the arts, buses on State Street and white-collar crime. In our retail listings, we noted which types of credit cards were accepted at which stores. Seriously, that was once a question to which you needed an answer.
We also discovered that, decades after our founding, many things about Madison remain the same: our commitment to locally produced goods, which is depicted in regular tales of farmers' markets, co-ops and successful entrepreneurships; our pride in innovation, as evidenced by the scores of stories on medicine and technology; our passion for politics; and our love of a good athletic event, as shown through countless profiles on star athletes and teams that made us stand up and cheer.
Over the course of the past thirty-five years, it would be an understatement to say that Madison has seen a steady cast of characters who have motivated, entertained and bewildered their fellow citizens. Best of all, as we realized by leafing through our own back pages, we have had the pleasure of interviewing many of them. So we wondered, where are these people now?
We caught up with thirty-five of them, and they all said that living, working or playing in Madison shaped them, often in fundamental ways. We say, in return for that influence, that they, knowingly or not, helped shape Madison. Each was featured in at least one past issue of the magazine, with many—but probably not all—of those issues noted by name.
Of our thirty-five, there are those we said would go places and, of course, they did. The water-skiing Larsen twins and the rockers of Garbage, for example. Others, like opera singer Kitt Reuter-Foss, haven't changed much, which we couldn't be happier about. Some, like politico Bill McCoshen, were young professionals in a hurry whose stars rose swiftly. Some, like politician Tammy Baldwin, moved steadily up the ladder to lofty heights, and others, like former police chief David Couper, made new and innovative contributions to their old professions. And then there are those who started in one place, moved forward to another, and came full circle back to where they had been in the first place. Yep, Mr. Mayor, we're looking at you.
Regardless of what their ZIP codes are now, each of these people made their mark on our city's incredibly rich history. They made us laugh. They frustrated us. They made us think. They inspired us and educated us.
Enjoy looking back and catching up. We sure did.
Click here to see our 35 local icons
Local and Regional News
- Poynette woman calls for action over million-dollar scam
- College student killed during a hammer throw event
- New Zealand: Janesville doctor must pay reparations for deadly crash
- Memorial High all-school read sparks conversations about race, social justice
- Crazylegs run/walk to close many downtown streets Saturday
- Delavan man killed in motorcycle vs. tree crash, officials say
- Beverage company workers accused of stealing company's booze
- Robbers target east side pizzeria for second time in week
- Food delivery drivers targeted in Madison robberies, police say
- Witness: Man points gun at kids playing basketball
- GOP Legislature calls redistricting ruling 'dangerous'
- Dane County to acquire 130 acres along Yahara River


text:
Below is a list of Obama's economic transition team. Numerous people here have directly called Obama a marxist and/or a socialist.
Could those that have called him this please point out who on his economic team fit these categories and provide some evidence? Thanks in advance.
David Bonior (Democratic member of the House of Representatives, 1977-2003)
Warren Buffett (chairman and CEO, Berkshire Hathaway) will participate via speakerphone
Roel Campos (former commissioner at the Securities and Exchange Commission)
William Daley (chairman of the Midwest, JPMorgan Chase; former secretary, U.S. Dept of Commerce, 1997-2000)
William Donaldson (former chairman of the SEC, 2003-2005)
Roger Ferguson (president and CEO, TIAA-CREF and former vice chairman of the Board of Governors of the Federal Reserve)
Jennifer Granholm (governor, state of Michigan)
Anne Mulcahy (chairman and CEO, Xerox)
Richard Parsons (chairman of the board, Time Warner)
Penny Pritzker (CEO, Classic Residence by Hyatt)
Robert Reich (professor, Goldman School of Public Policy, University of California, Berkeley; former secretary, U.S. Dept of Labor, 1993-1997)
Robert Rubin (chairman and director of the executive committee, Citigroup; former secretary, U.S. Department of Treasury, 1995-1999)
Eric Schmidt (chairman and CEO, Google)
Lawrence Summers (managing director, D.E. Shaw; former president of Harvard University; former secretary, U.S. Department of Treasury, 1999-2001)
Laura Tyson (professor, Haas School of Business, University of California, Berkeley; former chairwoman, National Economic Council, 1995-1996; former chairwoman, Presidents Council of Economic Advisors, 1993-1995)
Antonio Villaraigosa (mayor, city of Los Angeles)
Paul Volcker (former chairman, U.S. Federal Reserve 1979-1987)


text:
I can her pup now..."OH $H!T!"
Kendall Layne
Dorie's Lady of the Lake(1K bird club)
Never play leap frog with a unicorn.
If he was DQ'd for that I call BS!
That's my boy "Blue"!!!! Flyin High in the Passenger Side x Katie May of Belgrade
Was it delivered to hand?!!!
HR Chief's Ogeechee Mule - "Geech" - The Boykin
2014 BSS Upland Novice 3rd Place
2012 BSS Puppy Reserve JAM
IMO Wager's Buckhead Boo - "Boo" - My old Chocolate Lab - RIP Buddy
I don't care how good the pedigree is, their still s**t eating dogs.
Superb photograph. Thank you for sharing.
Feared by ducks, envied by hunters and loved by dogs.
Nomadic Retrievers
That's hilarious!!! I could see my dog doing that.
Great pick FP, would love to know who the dog was. Was your beautiful wife out there taking them?
That looks like the derby, so he was stuck out there with me. Frank is talented, he can shoot with more than just that 10 pound camera. There were several dogs that gave that cow pie a good sniff.
Gavin B.
FC AFC Wing Magic's Louisiana Roux MH "Roux"
GRHRCH Bayou Magic's Tough as a Boot QAA "Boot" (still a Knucklehead Puppy)
Bayou Magic's Reverend Jackson "Jesse" (Knucklehead Puppy)
"Never let the fear of striking out get in your way." -- George Herman Ruth


text:
Web Stories
Krueger wins Mahalanobis Memorial Medal
Posted January 10, 2002; 06:06 p.m.
Professor Alan Krueger is co-winner of the Mahalanobis Memorial Medal for 2000 from The Indian Econometric Society, along with Abhijit Banerjee of the Massachusetts Institute of Technology.
This prestigious award is presented for "outstanding contributions to quantitative economics." It is given once every five years.
Krueger is the Bendheim Professor of Economics and Public Affairs in the Woodrow Wilson School of Public and International Affairs.
Krueger's primary research and teaching interests are in the general areas of labor economics, industrial relations and social insurance. He served as chief economist at the U.S. Department of Labor in 1994-95. He is also the editor of the Journal of Economic Perspectives.
Contact: Marilyn Marks (609) 258-3601


text:
|Worldwide Flyfishing Discussion Talk flyfishing with members around the world!
|Thread Tools
|Search this Thread
|Rate Thread
|Display Modes
Selecting a new Fly Rod
I am planning on purchasing a small stream fly rod, but there are so many out there I would like some help. I would like a rod around 8 feet and 3-4 weight. However, I do alot of nymph fishing in small streams and wonder if the the short length of the rods I'm considering would be a problem. The two rods I am looking at are both pack rods around the same price ($280). They are the Scott SAS 8' #4; 3piece rod with a medium-fast action and the St. Croix Legend Ultra 7'9'' #3; 3piece with a fast action. I can't decide which rod would be best for the money and for both nymph and dry fly fishing in smaller streams. I know that I would probably need a longer rod for nymph fishing, but I really need a short rod for the streams I fish and wonder if these rods could get it done.
Colin Anderson
RE:Selecting a new Fly Rod
Colin -
Great topic, I live near some small streams and although I had been living out in the pacific northwest (long rods) for many years I have recently begun to re-think the stream strategy.
Last year I used an 7' 9" Sage LL 3wt with a floating double taper. It was a slower rod, but like all Sage graphites it is not lacking in the ability to create a tight loop. The old LL's were much slower than the RPL and other rods. These have been re-visited for 2001 - the LL has been replaced with the VPS light series; the RPL with VPS; RPLX with RPLXi; etc. These are not the exact same rods - for instance the old RPLX was very stiff, the RPLXi is just as fast but not stiff at all.
I like the slow action for small dry fly work in streams because there is no need to cast far, and there is a lot of finesse roll casting and a high demand for a delicate presentation. These graphite rods provide a distinct pendulum loadpoint and are cane-like (sort of).
I like the shorter lengths because I need to bushwhack thru the brush a lot out here, and longer rods make it that much harder even when I walk with the rod tip backwards.
It's true that a highstick nympher prefers a longer rod - but you can get away with a elkhair / deerhair / high floating dry fly (humpy, trude, caddis, etc) with a flourocarbon dropper and a beadhead nypmh. Fish the dry like you normally would and the fish will hit either fly. If you nymph with an indicator and practice good line management (mending and positioning, cleaning and treating, etc) the extra 12-18 inches aren't the most important factor.
Caveat: for stillwater ponds and lakes, and big west coast rivers - the short softer rods are not the ticket. Test cast the new SAGE XP 4wt for an example of a good trout rod for big waters, the 9'6" 8wt is a good steelhead and salmon rod; Spey rods in 14-15 foot lengths, etc.
Link to SAGE's VPS light page
Provided you are fishing streams with light lines and you're not going to want to do distance casting with the rod, the shorter finesse rods would be my choice.
If you want something that will give you the firepower on lakes and big rivers, I would go for something a little longer, bigger, and faster.
If I could only have one rod I would opt for an 8.5' 5wt to cover everything trouty... but it's not ideal for streams nor big water. That's tough to explain to my wife though
RE:Selecting a new Fly Rod
3wt 7'9" would be hard to nymph with. I would go with the 8' 4wt. That will still be a fun rod with small fish.
RE:Selecting a new Fly Rod
I will throw this into the mix--for the same price you can also get the 8 1/2' 4 wt. St. Croix Legend Ultra, which is a 4 piece. At last year's ff show I tried a bunch of 4 wts and settled on that one because I thought it was the perfect do-everything rod for where I fish--small streams, medium rivers, ponds etc. It also casts great. I got down to between that and a Sage but can't remember which one, I think the VPS, which I believe Juro recommended to me at the show, but I recall it being over $300. The St. Croix has been a good nymphing rod for me and also throws an intermediate line well for the small kettle pond fishing that I have been trying, mostly unsuccessfully, to get into...
It is by no means slow, but I would not consider it super fast action by today's standards. I found 8 1/2 to be a good length because my roll cast tends to suffer with shorter rods (but that could me!).
RE:Selecting a new Fly Rod
If in your case it is really a compromise between a small stream rod and a nymphing rod, then I think it is no compromise at all. I have casted both rods in the past, though probably the 5 weight jobs. I would tend to side with the Scott ASA which has a more progressive taper, as opposed to a faster action rod like the St Croix Legend Ultra, for the reasons Juro indicated. If the streams you fish are small and perhaps even brushy, then the 8 footer has an advantage over anything longer... control in tight quarters is everything. Also, if casts tend to be really short you may end up overlining the rod anyway. For instance, if you find yourself nymphing much of the time with a 7 or 9 foot leader plus 15' of line out, you may want to overline the thing with a 5 weight line, in order to load it more easily and so that it responds nicely without any jerkiness. The action of the Scott would also help casting dry and nymph jobs like say, a Klinkhammer to which you attach a small nymph to prospect small pockets and runs. This is a fun way to fish small water. Then again, I'm not sure how small a stream you're talking about. Hope this helps.
RE:Selecting a new Fly Rod
Colin -
When I first started fly fishing, the only fly rod I had was a 7 1/2 foot Shakespeare Wonderod. Glass naturally. Talk about being limited, but it really didn't matter. Made that rod do so many thing never thought possible. Back then, rods were not graded. It took experience to match the line with the rod. Sometimes it took several lines changes to get it right. HCH was the system they use to grade fly lines. The middle letter meant the weight and would change accordingly. Ex. HDH (heavier line)
Whenever I rolled cast, I could always keep up with longer rods. Probably because I honed my skills using just one rod. People were amaze how far I could get that rod out there. Things are very different today. Don't know your casting techniques in the rivers you fish, but roll casting was predominate here in RI.
My opinion is that length is not the really a factor in roll casting, but the transfer of energy is. A mid to full flex rod will keep the coil moving longer, much better than a fast tip rod that imparts the energy quicker. Fly presentation is the other principle most of us are concerned about when trout fishing. How the fly lands? Fast action rods are incapable of presenting a dry fly correctly. Line will slap the water. You want to land that fly like a butterfly with sore feet. Mid flex will give you an all around good stick for trout fishing. Stick with the rod that fits your primary way of fishing. If it's small streams, down size.
|Thread Tools
|Search this Thread
|Display Modes
|Rate This Thread
Linear Mode
|Similar Threads
|Thread Starter
|Last Post
|need help selecting saltwater fly reels
|Bonefish, Tarpon, and other Obsessions
|AUS bloke needs help please, selecting a SAGE rod
|the Rod Rack
|Selecting bonefish flies
|Bonefish, Tarpon, and other Obsessions
|Gear Talk - Fly Stuff Spoken Here
|Need Advice Selecting First 8 Weight
|Gear Talk - Fly Stuff Spoken Here


text:
Lymphocyte Depletion and Stem Cell Transplantation to Treat Severe Systemic Lupus Erythematosus
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
This study will examine a new approach to treating patients with severe systemic lupus erythematosus (SLE) that involves collecting stem cells (cells produced by the bone marrow that develop into blood cells) from the patient, completely shutting down the patient's immune system, and then giving back the patient's stem cells. SLE is a chronic, inflammatory disorder of the immune system that can affect many organs. It is called an autoimmune disease because the patient's lymphocytes (white blood cells that normally protect against invading organisms), go out of control and attack the body's own tissues.
Patients between 15 and 40 years of age with severe SLE affecting a major organ that is resistant to standard treatment may be eligible for this study. Candidates are screened with a medical history and physical examination, blood and urine tests, skin tuberculin test, and radiology studies to evaluate the extent of disease. They have endocrinology, nutrition, dental, and social work consultations, ultrasound or MUGA (multi-gated acquisition scan) scan heart imaging, electrocardiogram and lung function tests, bone marrow biopsy, and lymph node aspirate. Depending on which organs are affected, patients may have additional tests, such as lumbar puncture (spinal tap), kidney or lung biopsy, MRI (magnetic resonance imaging) of the brain and spinal cord, and PET (positron emission tomography) scan. They also complete quality of life questionnaires and have disability functional testing and neurocognitive (thinking) assessments.
Participants have a central venous line (plastic tube) inserted into a neck or chest vein for administering stem cells and medicines and for drawing blood. They undergo seven apheresis procedures during the course of the study to collect stem cells for transplant and for research. For apheresis, whole blood is collected through a needle in an arm vein and directed to a cell-separating machine where the white cells are extracted and the rest of the blood is returned to the patient through the same needle.
Patients are primed with three medications (methylprednisolone, rituximab, and cyclophosphamide) through the central line to help control the disease. In addition, a medication called G-CSF (growth colony stimulating factor) is injected under the skin for several days to boost production of stem cells. After enough stem cells have been collected for transplantation (infusion through the central line), patients are admitted to the hospital for an 8-day conditioning regimen followed by transplantation. The conditioning treatment consists of rituximab, fludarabine, and cyclophosphamide to eliminate all the white blood cells from the blood and bone marrow. The stem cells are then infused and the patient is closely monitored by a team of physicians and nurses. When the stem cells have engrafted, the bone marrow has recovered, and the patient feels well enough - usually 2 to 3 weeks after transplant - the patient is discharged from the hospital. Prednisone tapering begins as soon as feasibly possible, but no later then 28 days after transplant.
Patients return to the National Institutes of Health (NIH) Clinical Center for frequent follow-up visits during the first 2 to 3 months following transplant. The time between visits is then extended to once every 3 months the first year, then every 6 months the second year, and then at least yearly for 5 years after the transplant. These visits include a physical examination, blood and urine tests, lumbar puncture (if there is central nervous system involvement), other appropriate biopsies and tests as needed to monitor the patient's health, short apheresis procedures to collect blood for research purposes, and quality of life questionnaires. Some select procedures will be optional. Bone marrow biopsies and lymph node aspirates are done at beginning and at 6, 12, and 24 months after transplant. PET scans are done at 1, 6, 12, and 24 months.
Lupus Erythematosus, Systemic
Drug: fludarabine phosphate
Drug: cyclophosphamide
Biological: Rituxan (rituximab)
Biological: filgrastim
Drug: methylprednisolone
Other: immunologic technique
Other: laboratory biomarker analysis
Procedure: autologous hematopoietic stem cell transplantation
Drug: Diphenhydramine
Drug: Mesna
Phase 2
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A Pilot Study of Intensified Lymphodepletion Followed by Autologous Hematopoietic Stem Cell Transplantation in Patients With Severe Systemic Lupus Erythematosus
- Relapse-free Complete Clinical Response [ Time Frame: 60 months ]
- Number of Participants With Adverse Events [ Time Frame: 18 months ]Here is the number of participants with adverse events. For a detailed list of adverse events, see the adverse event module.
|Study Start Date:
|January 2004
|Study Completion Date:
|October 2013
|Primary Completion Date:
|October 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Autologous HSCT in SLE
Autologous hematopoietic stem cell transplantation (HSCT) in systemic lupus erythematosus (SLE).
SLE is a chronic, inflammatory disease of the immune system. Participants received a priming, conditioning and transplant regimen. Priming regimen consisted of treatment with rituxan, filgrastim, cyclophosphamide, mesna, fludarabine phosphate, and methylprednisolone. Conditioning and transplant regimen consisted of fludarabine, cyclophosphamide, rituxan, filgrastim, mesna, diphenhydramine and stem cell transplant infusion.
Drug: fludarabine phosphate
Conditioning and transplant regimen: 30 mg/m^2 day intravenous infusion over 30 minutes daily, 4 days (transplant days -6, -5, -4, -3)
Other Name: FludaraDrug: cyclophosphamide
Priming regimen: 2000 mg/m^2 intravenous infusion over 2 hours, day 2. Conditioning and transplant regimen: 1200 mg/m^2 day intravenous infusion daily, 4 days (-6, -5, -4, -3).
Other Name: CytoxanBiological: Rituxan (rituximab)
Priming regimen: 375 mg/m^2 intravenous day 1, 4. Conditioning and transplant regimen: 750 mg/m^2 intravenous infusion, day -7.
Other Name: RituximabBiological: filgrastim
Priming regimen: 10 micrograms/kg/day subcutaneous, starting day 6. Conditioning and transplant regimen: 5 micrograms/kg/day subcutaneous, day +1 until ANC >500 microliters.
Other Name: GCSF (growth colony stimulating factor)Drug: methylprednisolone
Priming regimen:1000 mg intravenous over 30 minutes, day 1.
Other Name: MedrolOther: immunologic technique
Lymphoablative regimen using cyclophosphamide, rituximab, and fludarabine followed by a CD34 cell selected autologous stem cell transplant.Other: laboratory biomarker analysis
Standard human immunology research laboratory ex vivo studies.Procedure: autologous hematopoietic stem cell transplantation
Day 0, product will be infused rapidly intravenously after premedication with diphenhydramine 25-60 mg orally or intravenous.Drug: Diphenhydramine
Conditioning and transplant regimen 25-50 mg orally or intravenously.
Other Name: BenadrylDrug: Mesna
Priming regimen: 600 mg/m^2 intravenous immediately prior to cyclophosphamide and repeat at 4 and 7 hours after the first dose, day 2. Conditioning and transplant regimen:1200 mg/m^2 per day continuous 24 hour intravenous infusion, daily for 4 days, start concurrently with the start of cyclophosphamide.
Other Name: Mesnex
Detailed Description:
- Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that can involve almost any organ and can range in severity from mild to life-threatening. In spite of significant improvements in survival of SLE patients over last 20 years, a small but significant portion of patients still develop progressive therapy-refractory disease that impairs organ function and overall survival.
- Since 1996, more than 500 patients have been treated worldwide in pilot trials of autologous hematopoietic stem cell transplantation (autoHSCT) for autoimmune diseases, including about 80 patients with SLE.
- The rationale for autoHSCT in autoimmune disease is to ablate autoreactive immune effectors and allow reconstitution of a new self-tolerant immune system from the
hematopoietic stem cell. Studies have demonstrated acceptable safety and promising short term efficacy of high-dose cyclophosphamide-based (200 mg/kg) autoHSCT for about 60% of patients with advanced refractory SLE and reacquisition of sensitivity to conventional drugs have been demonstrated in many cases. However, these trials were designed to address the primary endpoint of safety and were inadequate for assessing the disease response.
-Numerous questions about the true efficacy of autoHSCT, optimal transplant regimen, patient selection and mechanisms of action remain unaddressed.
- The primary objective is to assess the rate of continuous relapse-free complete clinical responses at 24 months post-transplant, with statistical power of 84% to detect, if greater than 70 percent of patients meet the primary endpoint.
- The long-term goal of this research is to develop a basis for future transplant protocols that would incorporate new cellular or other immunotherapeutic interventions to further improve results of transplants with the ultimate goal to cure SLE.
-Subjects age 15-40 years who fulfill at least 4 of the 11 criteria for SLE as defined by the
American College of Rheumatology
-Have severe and active lupus, refractory to immunosuppressive therapy. Included are subjects with nephritis, central nervous system (CNS) lupus, pulmonary lupus or hematologic disease
- Fourteen patients with active and standard dose cyclophosphamide-resistant SLE will be enrolled on this phase II pilot study.
- Study design is intended to improve the efficacy of autoHSCT. A lymphoablative conditioning regimen (rituximab, fludarabine and cyclophosphamide) is explored for the first time in autoimmune disease.
- The treatment schedule consists of two parts; the priming regimen prior to stem cell mobilization and collection, and the conditioning regimen with transplant.
- In contrast to other studies, this study has precisely defined eligibility and disease response criteria with strict schema of tapering immunosuppression that should allow accurate interpretation of the treatment results.
- The study includes a carefully chosen battery of laboratory research studies designed to investigate SLE biology and mechanisms of post-transplant responses.
|Ages Eligible for Study:
|15 Years to 40 Years (Child, Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- Age 15-40 years
Must fulfill at least 4 of the following 11 criteria for systemic lupus erythematous (SLE) as defined by the American College of Rheumatology:
-Malar rash. Fixed erythema, flat or raised, over the malar eminences, tending to spare the nasolabial folds.
- Discoid rash. Erythematous raised patches with adherent keratotic scaling and follicular plugging; atrophic scarring may occur in older lesions.
- Photosensitivity. Skin rash as a result of unusual reaction to sunlight, by patient history or physician observation.
- Oral ulcers. Oral or nasopharyngeal ulcerations, usually painless, observed by a physician.
- Arthritis. Nonerosive arthritis involving two or more peripheral joints, characterized by tenderness, swelling, or effusion.
- Serositis. a.) Pleuritis - convincing history of pleuritic pain or rub heard by a physician or evidence of pleural effusion
b.) Pericarditis - documented by electrocardiogram (ECG) or rub or evidence of pericardial effusion
-Renal disorder. a.) Persistent proteinuria greater than 0.5 grams per day or greater than 3+ if quantitation not performed
b.) Cellular casts - may be red cell, hemoglobin, granular, tubular, or mixed.
- Neurologic disorder. a.) Seizures - in the absence of offending drugs or known metabolic derangements; eg, uremia, ketoacidosis, or electrolyte imbalance
b.) Psychosis - in the absence of offending drugs or known metabolic derangements; eg, uremia, ketoacidosis, or electrolyte imbalance
-Hematologic disorder. a.) Hemolytic anemia - with reticulocytosis
b.) Leukopenia - less than 4000/ L total on two or more occasions
c.) Lymphopenia - less than 1500/ L on two or more occasions
d.) Thrombocytopenia - less than 100,000/ L in the absence of offending drugs
- Immunologic disorder. a.) Anti-deoxyribonucleic acid (DNA): antibody to native DNA in abnormal titer
b.) Anti-SM: presence of antibody to SM nuclear antigen
c.) Positive finding of antiphospholipid antibodies based on (1) an abnormal serum level of immunoglobulin G (IgG) or immunoglobulin M (IgM) anti-cardiolipin antibodies, (2) a positive test result for lupus anticoagulant using a standard method, or (3) false positive serologic test for syphilis known to be positive for at least 6 months and confirmed by Treponema Pallidum immobilization or fluorescent treponemal antibody absorption test
-Antinuclear antibodies. An abnormal titer of ANAs by immunofluorescence or an equivalent assay at any point in time in the absence of drugs known to be associated with drug-induced lupus syndrome.
Have severe and active lupus, refractory to immunosuppressive therapy, defined as one of the following (a-d):
a.Nephritis: Biopsy proven Diffuse Proliferative Glomerulonephritis (World Health Organization (WHO) Class IV) with or without superimposed membranous changes
i.Active disease:
- A kidney biopsy within three months of enrollment showing active WHO Class IV disease. Activity will be determined based on the presence of endocapillary cellular proliferation compromising the capillary loops or cellular crescents or necrosis on light microscopy or subendothelial deposits on electron microscopy.
If a biopsy is contraindicated patients can be enrolled if they had a previous biopsy showing Diffuse Proliferative Glomerulonephritis (WHO Class IV) and at the time of enrollment have all of the following:
- Proteinuria greater than 1gm/day
- Active urine sediment defined as hematuria (greater than 10 red blood cell (RBC)/hpf (high power field) on a nephrology urinalysis of a 50 mL urine sample) with dysmorphic RBC and/or cellular casts on a nephrology urinalysis of a 50 mL urine sample
- Low C3 (less than 69 mg/dL) and/or elevated dsDNA antibodies (greater than 25EU)
- Need for prednisone greater than 20 mg/day due to increased renal activity after at least 6 months of cyclophosphamide.
ii. Treatment resistant:
- Patients with active disease after at least 6 months of intravenous pulse cyclophosphamide +/- iv methylprednisolone and daily oral prednisone, or
- Early flare: those who have reactivation of their nephritis during or within 6 months of completing cyclophosphamide therapy
Recalcitrant disease: two or more recurrences of lupus nephritis within five years of enrollment. All flares must have received adequate therapy and least one of the episodes must have been treated with minimum 6 months of intravenous pulse cyclophosphamide plus iv methylprednisolone and maintenance oral prednisone.
Central nervous system (CNS) lupus: Lupus CNS manifestations indicative of encephalitis or myelitis or vasculitis. Concomitant CNS diseases should be excluded. (e.g. infections, multiple sclerosis; patients fulfilling multiple sclerosis (MS) and SLE criteria will be excluded). Clinical signs and symptoms must be supported by objective findings of CNS inflammation.
i. Active disease:
Signs/symptoms that are accepted for disease activity:
-Clinical signs and symptoms compatible with focal CNS damage -Severe global neurocognitive/psychiatric impairment (eg: psychosis, organic brain syndrome, severe depression)
-Intractable seizures
Clinical findings must be supported by at least one of the following:
Magnetic resonance imaging (MRI) findings consistent with transverse myelitis or
Central nervous system (CNS) vasculitis
- Signs of inflammation on MRI are either the presence of Gadolinium (Gd)-enhancing lesions, or the increase of the number and/or volume of T2-weighted lesions (or lesions showing up on fluid attenuated inversion recovery (FLAIR) imaging). We will use the standard MS protocol sequences, which are routinely used in the Clinical Center to evaluate inflammatory CNS lesions.
- If patient has seizures/psychiatric signs and symptoms in the absence of clear signs of vasculitis or cerebritis by MRI, the cerebral spinal fluid (CSF) should show protein elevation above normal levels and abnormal number of white blood cells (WBCs) or intrathecal IgG synthesis/or oligoclonal bands.
- Need for prednisone greater than 20 mg/day due to increased CNS activity (see above) after at least three months of cyclophosphamide therapy.
ii-Treatment resistant:
a) Active disease after a minimum of three months of oral or intravenous cyclophosphamide, or
b) Early flare: reactivation of CNS lupus within 6 months of completing cyclophosphamide therapy
c. Recalcitrant disease: two or more recurrences of CNS lupus within five years of enrollment. All flares must have received adequate therapy and at least one of the episodes must have been treated with minimum three months of oral or intravenous cyclophosphamide.
Pulmonary lupus
i. Active disease:
- Lung biopsy showing active pneumonitis, alveolitis or pulmonary vasculitis after the minimally required therapy within one month of enrollment or
- If a biopsy is contraindicated within one month of enrollment, patients may be included if they had a biopsy at the start or during cyclophosphamide treatment showing active pneumonitis, alveolitis or pulmonary vasculitis (as above) and have abnormal or worsening pulmonary function tests with a chest computed tomography (CT) consistent with active pneumonitis, alveolitis or vasculitis within 2 weeks of enrollment and at the time of enrollment have a CT consistent with active disease.
Need for prednisone greater than 20 mg/day due to increased pulmonary lupus activity after minimum of three months of cyclophosphamide.
ii. Treatment resistant:
- Ongoing or recurrent active pulmonary lupus after a minimum of three months of oral or intravenous cyclophosphamide, or
- Early flare: reactivation of pulmonary lupus (as defined above) within 6 months of completing cyclophosphamide therapy.
- Recalcitrant disease: two or more recurrences of pulmonary as described above within five years of enrollment. All flares must have received adequate therapy and at least one of the episodes must have been treated with minimum 3 months of oral or intravenous cyclophosphamide.
i) Active disease:
a) Severe immune-mediated thrombocytopenia (platelet count less than 20,000/mm^3 or less than 50,000/mm^3 with history of bleeding), or
b) Severe immune-mediated anemia (requiring transfusions to maintain hemoglobin (Hb) greater than 8.0 g/dL or to treat symptoms of anemia) c) Need for prednisone greater than 20 mg/day due to increased hematologic lupus activity after therapy as described in section ii.a).
ii) Treatment resistant:
a) Active disease as defined above after a minimum of three months of high dose oral or pulse corticosteroids +/- intravenous immunoglobulin (IVIg) (or WinRho) and splenectomy, or
b) Early flare: reactivation of hematologic lupus (as defined above) within 6 months of completing above therapy.
c) Recalcitrant disease: two or more recurrences of immune-mediated thrombocytopenia or anemia, as described above, within five years of enrollment. All flares must have received adequate therapy and at least one of the episodes must have been treated by splenectomy.
1. Inability to provide written informed consent prior to entry in the protocol
2. Pregnant or lactating women. Women of childbearing potential are required to have a negative pregnancy test at screening
3. Women of childbearing potential who are not practicing or who are unwilling to practice birth control during the entire study
4. Men who are unwilling to practice birth control for the first 6 months after the transplant
5. Evidence of infection with hepatitis B, hepatitis C, or human immunodeficiency virus (HIV)
6. History of malignancy other than basal cell carcinoma of the skin
7. Carbon monoxide diffusing capacity (DLCO) corrected less than 45%
8. Left ventricular ejection fraction (LVEF) less than 45%, determined by ECHO cardiogram or MUGA
9. Serum glutamic oxaloacetic transaminase (SGOT) or serum glutamic pyruvic transaminase (SGPT) greater than 2x upper limit of normal (unless active myopathy is proven by elevation of serum aldolase levels and the patient has no obvious hepatic disease) and/or bilirubin greater than 2.0 (unless due to isolated hemolysis).
10. Calculated glomerular filtration rate less than 30 ml/min using the modification of diet in renal disease (MDRD) equation estimate:
Glomerular filtration rate (GFR) (ml/min/173 m^2) =186.3 x (Pcr) exponential -1.154 x (age) exponential -0.203 x 1.212 (if black) x 0.742 (if female)
11. Late flare (patients who have target organ flare, that is not within the time frame defined as early flare, will not be considered as treatment failures until they receive the minimally required therapy for this flare episode and fail to respond to it)
12. Abnormal bone marrow cytogenetics
13. Significant concurrent medical condition or any significant circumstance that could affect the patient's ability to tolerate or complete the study
14. Live vaccines within 4 weeks of starting the priming regimen
Please refer to this study by its ClinicalTrials.gov identifier: NCT00076752
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|Principal Investigator:
|Steven Pavletic, M.D.
|National Cancer Institute (NCI)
|Responsible Party:
|Steven Pavletic, M.D., Principal Investigator, National Institutes of Health Clinical Center (CC)
|ClinicalTrials.gov Identifier:
|NCT00076752 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
|Study First Received:
|February 2, 2004
|Results First Received:
|March 25, 2014
|Last Updated:
|June 13, 2014
Keywords provided by National Institutes of Health Clinical Center (CC):
Refractory SLE
Immunological Recovery
Mechanism of Disease
Systemic Lupus Erythematosus
Additional relevant MeSH terms:
Lupus Erythematosus, Systemic
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases
Fludarabine phosphate
Methylprednisolone Hemisuccinate
Prednisolone acetate
Methylprednisolone acetate
Prednisolone hemisuccinate
Prednisolone phosphate
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Antirheumatic Agents
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Myeloablative Agonists
Antimetabolites, Antineoplastic
ClinicalTrials.gov processed this record on April 28, 2017


text:
Precious little has come down to us of the years Jesus spent in Nazareth, leading scholars to describe this time, practically Jesus' whole life, as "the silent years." It is thus all the more significant for Christian visitors here to find a place where the silence is broken – the Synagogue Church. Tradition says this is the spot, one memorable Sabbath day, where Jesus stood to proclaim and preach the stirring words of Isaiah 61 (Luke 4:16-27) and where he endured an angry response (Luke 4:28-30). You'll find the Synagogue Church just a few minutes walk into the Old Market.
Christians have been coming here at least since the sixth century, and in 1771 the Greek Catholics received it into their care. In this unadorned stone chamber beneath fine old barrel arches, a quiet enclave awaits where you can delve into this complex story that so dramatically reflects the reality of its time and place.


text:
Now, more than any other time of the year, a brand-new wardrobe is every hot-blooded woman's fantasy. After all, the weather is warming up, the layers are coming off, and there is suddenly a burning desire to show off everything—from your legs to your ears—that has been kept hidden all winter long.
Here, we bring you Vogue's Spring Fashion Under $100 Guide. Based entirely off the trends (from punk to florals) found on the runways and within the pages of the most recent issues of Vogue, here are endless ways to make a big impression at a very pleasing price.
MORE From VOGUE:
YSL La Laque Couture in Noir Primitif, $25
(See more: Beauty must-haves for spring 2013)
RACHEL Rachel Roy hematite tone safety-pin earrings, $26
ASOS Story heel, $67
Jeffrey Campbell In Love flat, $90; nordstrom.com
Express striped ponte knit fit-and-flare dress, $56
Kate Spade iPhone 5 case, $25saturday.com
A|X Armani Exchange color-blocked shoulder bag, $78armaniexchange.com
Zara platform ankle-strap sandal, $80; zara.com
Julie Vos Nile ring, $68
Michael Kors gold-tone link ring, $75
Low Luv Cosmos double finger ring, $80
Melinda Maria Titus ring, $58maxandchloe.com
Converse Chuck Taylor All Star washed in Stellar, $70
Redken Wool shake gel-slush texturizer, $18
Topshop floral jacquard dress, $64nordstrom.com
MIA Crusader moto ankle boot, $60 miashoes.com
Bebe Layered snake chain earrings, $24
From left:Soludos Choo Choo light-blue denim espadrille, $36 soludos.com
TOMS chambray trim classics, $54 toms.com
Kure Bazaar Jeans collection in Stone Wash, Rock Star, Hipster, and Mon Bleu, $16 eachspiritbeautylounge.com
Clockwise from top left:
Zara trousers with elastic hem, $60 zara.com
Adidas by Stella McCartney asymmetrical swimsuit, $80 adidas.com
Helmut Lang tread skinny leather belt, $90 helmutlang.com
ASOS two-pack arm cuffs, $17.50 asos.com
Kelsi Dagger patent mini-wedge sandal, $99 urbanoutfitters.com
More from Vogue:
Michelle Obama's Best-Dressed Moments
- Arts & Entertainment


text:
This Volkswagen Golf Mk2 can beat the 2018 Dodge... Modified
April 28, 2017
April 28, 2017
First Drives
Auto Shows
Spy Shots
Car Tech
Struggling Swedish automaker Volvo announced back in June that it will releasing a new plug-in hybrid vehicle by 2012 as the latest step under its 'DRIVe Towards Zero'... read more September 21, 2009 by Nelson Ireson 0
Volvo has revealed the latest addition to its sporty R-Design line-up with the introduction of the all-new V70 R-Design wagon. Set to go on sale in Europe in August, the... read more May 8, 2008 by James Martinez 1
A completely undisguised version of Volvo's upcoming V70 was caught by spy photographer just outside Volvo's factory in Sweden. The particular model caught was a... read more October 10, 2006 by Ralph Hanson 0
Recently, images of a heavily disguised Volvo test mule have been circulating around the net. That image didn't really reveal any details, but the new car has been... read more October 5, 2006 by Viknesh Vijayenthiran 2
|MPG City
|MPG Hwy


text:
KathyChung, Friday March 19, 2010 - 11:58am
Happy Friday!
Time to introduce you to another brand new presenter, this time a Canadian who's part of the growing group of writers I know who avoid the dreaded effects of working at a desk all day by NOT working at a desk all day. Or at least not sitting at one. How do you write a book without sitting? I'll come back to that.
But first, meet ARTHUR SLADE.
Arthur Slade was raised in the Cypress Hills of southwest Saskatchewan and began writing at an early age. He received an English Honours degree from the University of Saskatchewan, spent several years writing advertising and now writes fiction full time. He is the author of the Canadian Chills series of books, Dust (which won the Governor General's award), Jolted, and The Hunchback Assignments series. He currently lives in Saskatoon.
You can learn more about Arthur Slade at his website: www.arthurslade.com.
Welcome, Art!
Oh, are you still wondering about writing a book without sitting at a computer?
Rumour has it Arthur Slade is one of the many writers who work while walking on a treadmill. (Actually, it's not just a rumour. I heard about it in his podcast interview with "Authors Like Us" interviewers, authors, and SiWC presenter alums James McCann and Lee Edward Fodi here.)
Anonymous replied on Permalink
Looking forward
Anonymous replied on Permalink


text:
Web Stories
Three elected to National Academy of Sciences
Posted May 22, 2001; 08:38 a.m.
Three Princeton faculty members were elected to the National Academy of Sciences at the academy's annual meeting May 1.
They are: Michael Bender, professor of geosciences; Robert Cava, associate director of the Princeton Materials Institute and professor of chemistry; and Daniel Kahneman, the Eugene Higgins Professor of Psychology and Public Affairs in the Woodrow Wilson School.
They were among 72 new members and 15 foreign associates elected this year, bringing the total number of National Academy members to 1,874 and the number of Princeton affiliated members to 58.
The National Academy of Sciences is a private organization of scientists and engineers dedicated to the furtherance of science and its use for the general welfare. It was established in 1863 by a congressional act of incorporation, signed by Abraham Lincoln, that calls on the academy to act as an official adviser to the federal government, upon request, in any matter of science or technology.
Contact: Marilyn Marks (609) 258-3601


text:
Jamie Meredith
As a Technical Account Manager, Jamie provides personalized one-on-one service to Enterprise client accounts. His responsibilities include insuring that clients receive superior architectural and technical support. Jamie has a broad background in web strategy, architecting and planning, with a focus on leveraging Drupal to productize and market customer products and services.
In Jamie's free time, you most likely find him leading a local user group / un-conference, spending time with his family or being creative in his studio/workshop. He is passionate about social change, homesteading, woodworking, painting, photography and Drupal (of course).


text:
Latest Headlines is home to all the latest, up to the minute news headlines from The Wall Street Journal in a streaming continuous headline experience.
By Jared A. Favole
Former President Bill Clinton speaks during the ceremony marking the 50th anniversary of the March on Washington, at the Lincoln Memorial in Washington, D.C., on Wednesday, Aug. 28, 2013. (REUTERS/Jason Reed)
Former Presidents Jimmy Carter and Bill Clinton hailed Martin Luther King Jr. on the 50th anniversary of his "I Have a Dream Speech," saying he ignited a wave of positive change for civil rights but his vision has yet to be fulfilled as economic inequality persists, prisons continue to fill with African Americans and attempts to restrict voting rights remain.
"There's a tremendous agenda ahead of us," Mr. Carter said, mentioning voting rights, jobs and guns and "stand your ground" laws. He also put in a plug for the effort to obtain full voting rights for District of Columbia residents. "I think we know how Dr. King would have reacted for people of District of Columbia still not having full citizenship rights," he said.
Mr. Clinton and Mr. Carter were speaking toward the end of a march and rally to mark the 50th anniversary of the civil-rights March on Washington for Jobs and Freedom. About 250,000 people attended that march in 1963 and the celebration Wednesday was expected to include 100,000. African-American luminaries such as Oprah Winfrey and civil rights icons such as Rep. John Lewis of Georgia spoke at the march and praised Dr. King's efforts on behalf of equality.
Mr. Clinton said despite inequality among races American citizens don't "face beatings, lynchings and shootings for our political beliefs anymore." And he criticized people for complaining of the country's current political logjam.
"I would respectfully suggest that Martin Luther King did not live and die to hear his heirs whine about political gridlock. It's time to stop complaining and put our shoulders against the stubborn gates holding the American people back," he said.
President Barack Obama, who has often complained about Washington's political gridlock, was the final speaker.
Mr. Clinton also told people not to be disheartened by the Supreme Court decision in June that nullified a core provision of the Voting Rights Act. The decision has sparked widespread concern among Democrats and the African American community that it will unleash efforts to suppress voters.
Mr. Clinton said despite restrictive voting laws in some states people "showed up, stood in line for hours and voted anyway. So obviously we don't need any kind of law." Still, he added, "A great country doesn't make it harder to vote than to buy an assault weapon."
Below, the full text of the remarks from former Presidents Jimmy Carter and Bill Clinton, as provided by Federal News Service (www.fednews.com)
PRESIDENT JIMMY CARTER: Well, I'm greatly honored to be here. And I realize that most people know that it's highly unlikely that any of us three over on my right would have served in the White House or be on this platform had it not been for Martin Luther King Jr. and his movement and his crusade for civil rights. So we are grateful to him for us being here. (Applause.)
I'm also proud that I came from the same part of the South as he did. He never lost contact with the folks back home. He was helping Tennessee garbage workers, as you know, when he gave his life to a racist bullet.
I remember how it was, back in those days. I left Georgia in 1943 for college and the Navy. And when I came home from submarine duty, I was put on the Board of Education. I suggested to the other members that we visit all the schools in the county. They had never done this before, and they were reluctant to go with me.
But we finally did it, and we found that white children had three nice brick buildings, but the African-American children had 26 different elementary schools in the county. They were in churches, in front living rooms and a few in barns. They had so many because there were no school buses for African-American children, and they had to be within walking distance of where they went to class. Their schoolbooks were outdated and worn out, and every one of them had a white child's name in the front of the book.
We finally obtained some buses. And then the state legislature ordained that the front fenders be painted black. Not even the school buses could be equal to each other.
One of the finest moments of my life was 10 months after Dr. King's famous speech right here, when President Lyndon Johnson signed the Civil Rights Act. I was really grateful when the King family adopted me as their presidential candidate in 1976. (Cheers.) Every handshake from Dr. King, from Daddy King, every hug from Coretta got me a million Yankee votes. (Laughter.)
Daddy King prayed at the Democratic Convention — for quite a while, I might say — (laughter) — and Coretta was in the hotel room with me and Rosalyn when I was elected president.
My Presidential Medal of Freedom citation to Coretta for Dr. King said, and I quote, "He gazed at the great wall of segregation and saw that the power of love could bring it down. He made our nation stronger because he made it better."
We were able to create a national historic site where Dr. King lived, worked and worshipped. It's next door to the Carter Center, linked together just by a walking path. And at the Carter Center, we try to make the (principles ?) that we follow the same as his, emphasizing peace and human rights.
I remember that Daddy King said, too many people think Martin freed only black people; in truth, he helped to free all people. (Applause.) And Daddy King added, it's not enough to have a right to sit at a lunch counter if you can't afford to buy a meal. And he also said, the ghetto still looks the same even from the front seat of a bus.
Perhaps the most challenging statement of Martin Luther King Jr. was, and I quote: "The crucial question of our time is how to overcome oppression and violence without resorting to oppression and violence." In the Nobel Prize ceremony of 2002, I said that my fellow Georgian was, and I quote again, "the greatest leader that my native state, and perhaps my native country, has ever produced." And I was not excluding presidents and even the Founding Fathers when I said this.
(Cheers, applause.)
I believe we all know how Dr. King would have reacted to the new ID requirements to exclude certain voters, especially African- Americans. I think we all know how Dr. King would have reacted to the Supreme Court striking down a crucial part of the Voters' Rights Act just recently passed overwhelmingly by Congress. I think we all know how Dr. King would have reacted to unemployment among African- Americans being almost twice the rate of white people and for teenagers at 42 percent. I think we would all know how Dr. King would have reacted to our country being awash in guns and for more and more states passing "stand your ground" laws. I think we know how Dr. King would have reacted for people of District of Columbia still not having full citizenship rights. (Cheers, applause.)
And I think we all know how Dr. King would have reacted to have more than 835,000 African-American men in prison, five times as many as when I left office, and with one-third of all African-American males being destined to be in prison in their lifetimes.
Well, there's a tremendous agenda ahead of us, and I'm thankful to Martin Luther King Jr. that his dream is still alive. Thank you. (Cheers, applause.)
PRESIDENT BILL CLINTON: Thank you.
Mr. President, Mrs. Obama, President Carter, Vice President Biden, Dr. Biden, I want to thank my great friend Reverend Bernice King and the King family for inviting me to be a part of this 50th observation of one of the most important days in American history.
Dr. King and A. Philip Randolph, John Lewis and Bayard Rustin, Dorothy Height, Myrlie Evers, Daisy Bates and all the others who led this massive march knew what they were doing on this hallowed ground.
In the shadow of Lincoln's statute, the burning memory of the fact that he gave his life to preserve the Union and end slavery, Martin Luther King urged his crowd not to drink from the cup of bitterness but to reach across the racial divide because, he said, we cannot walk alone. Their destiny is tied up with our destiny. Their freedom is inextricably bound to our freedom.
He urged the victims of racial violence to meet white Americans with an outstretched hand, not a clenched fist, and, in so doing, to prove the redeeming power of unearned suffering. And then he dreamed of an America where all citizens would sit together at the table of brotherhood, where little white boys and girls and little black boys and girls would hold hands across the color line, where his own children would be judged not by the color of their skin but by the content of their character.
This march and that speech changed America. They opened minds, they melted hearts and they moved millions, including a 17-year-old boy watching alone in his home in Arkansas. (Applause.) It was an empowering moment, but also an empowered moment. As the great chronicler of those years, Taylor Branch, wrote: The movement here gained the force to open, quote, "the stubborn gates of freedom," and out flowed the Civil Rights Act, the Voting Rights Act, immigration reform, Medicare, Medicaid, open housing.
It is well to remember that the leaders and the foot soldiers here were both idealists and tough realists; they had to be. It was a violent time. Just three months later, we lost President Kennedy and we thank God that President Johnson came in and fought for all those issues I just mentioned. (Applause.) Just five years later, we lost Senator Kennedy. And in between there was the carnage of the fight for jobs, freedom and equality. Just 18 days after this march, four little children were killed in the Birmingham church bombinng. Then there were the Ku Klux Klan murders, the Mississippi lynching and a dozen others until in 1968 Dr. King himself was martyred, still marching for jobs and freedom.
What a debt we owe to those people who came here 50 years ago. (Cheers, applause.) The martyrs played it all for a dream, a dream, as John Lewis said, that millions have now actually lived.
So how are we going to repay the debt? Dr. King's dream of interdependence, his prescription of wholehearted cooperation across racial lines — they ring as true today as they did 50 years ago. Oh, yes, we face terrible political gridlock now. Read a little history; it's nothing new. Yes, there remain racial inequalities in employment, income, health, wealth, incarceration, and in the victims and perpetrators of violent crime. But we don't face beatings, lynchings and shootings for our political beliefs anymore. And I would respectfully suggest that Martin Luther King did not live and die to hear his heirs whine about political gridlock. It is time to stop complaining and put our shoulders against the stubborn gates holding the American people back. (Cheers, applause.)
We cannot be disheartened by the forces of resistance to building a modern economy of good jobs and rising incomes or to rebuilding our education system to give our children a common core of knowledge necessary to ensure success or to give Americans of all ages access to affordable college and training programs. And we thank the president for his efforts in those regards. (Applause.)
We cannot relax in our efforts to implement health care reform in a way that ends discrimination against those with pre-existing conditions — one of which is inadequate income to pay for rising health care — (applause) — a health care reform that will lower costs and lengthen lives; nor can we stop investing in science and technology to train our young people of all races for the jobs of tomorrow; and to act on what we learn about our bodies, our businesses and our climate. We must push open those stubborn gates.
We cannot be discouraged by a Supreme Court decision that said we don't need this critical provision of the Voting Rights Act because, look at the states, it made it harder for African Americans and Hispanics and students and the elderly and the infirm and poor working folks to vote. What do you know; they showed up, stood in line for hours and voted anyway. So, obviously we don't need any kind of law. (Applause.)
But a great democracy does not make it harder to vote than to buy an assault weapon. (Cheers, applause.) We must open those stubborn gates.
And let us not forget that while racial divides persist and must not be denied, the whole American landscape is littered with the lost dreams and dashed hopes of people of all races. And the great irony of the current moment is that the future has never brimmed with more possibilities. It has never burned brighter in what we could become if we push open those stubborn gates and if we do it together.
The choice remains as it was on that distant summer day 50 years ago: cooperate and thrive or fight with each other and fall behind. We should all thank God for Dr. King and John Lewis and all those who gave us a dream to guide us, a dream they paid for, like our founders, with their lives, their fortunes, their sacred honor. (Cheers, applause.) And we thank them for reminding us that America is always becoming, always on a journey. And we all, every single citizen among us, have to run our length.
God bless them, and God bless America. (Cheers, applause.)


text:
Whether your nurses have simple or complex care-related questions, Lippincott Advisor gives your staff fast and easy access to answers from a source they can trust, whenever they need them, wherever they are.
Written by nurses for nurses, Lippincott Advisor is an expanding collection of more than 16,000 evidence-based entries and patient teaching handouts that cover:
What Lippincott Advisor Can Do for You
Eliminate wasted time spent on unreliable Internet searches
Empower your nurses with the knowledge and confidence to make clinical decisions and facilitate delivery of care in both familiar and unfamiliar settings or situations
Maintain compliance with current national guidelines including those from the Agency for Healthcare Research and Quality, the American Association of Critical Care Nurses, and alignment with Joint Commission standards and components of the Magnet Recognition Program®
Promote a consistent standard of care
Reduce the opportunity for error
Key Features
Clinical online reference tool available 24 hours a day, 7 days a week
Content is continually updated by clinical nurses to reflect the most current evidence and practice standards
Powerful search capability by keyword or category
Links to sources such as PubMed, OVID, and your organization's library for further reading and research
Customizable by adding notes on your organization's protocols, treatments, and other important information
New integrated search between Lippincott Advisor and Lippincott Procedures (for subscribers of both products) allowing users to view a procedure and quickly jump to the related patient teaching handout, disease, or drug.
Discover how Lippincott Advisor gives your nurses a point-of-care virtual library at their fingertips to help them better manage their workload, facilitate delivery of care, and make care decisions that consider evidence and current practice.


text:
Stylish Holiday Gifts Under $100
What I'm wishing for...
"A go-anywhere, keep-forever, beautiful, classic bag would be wonderful to receive. This one fits the bill perfectly."
Sofia Coppola for Louis Vuitton bag, $3,950, louisvuitton.com.
What I'm giving...
"In our digital world, what makes a better gift than the perfect Leica camera?"
Leica D-Lux 5 Digital Camera, $799, bhphotovideo.com.
Unique Gifts for a Stylish Life


text:
by Symantec
Feb 11, 2014
Download There seem to be three certainties in life: death, taxes and threats to our technology. And just as IT continues to play a pivotal role in today's business, attacks on our systems and information are constantly evolving. For each new patch or security feature implemented, the bad guys are waiting to counter it with a move of their own. And while we've become so accustomed to computer viruses that we consider them a simple fact of life, there are now far more sinister opportunities for data loss. From advanced persistent threats to malicious insiders, the result is a tangled landscape of security challenges that only appears to be getting worse. In order to assess how well companies today are coping with this complex security situation, Symantec fielded a survey at the 2014 RSA Conference in San Francisco. We asked more than 300 attendees about their level of preparedness and their confidence in their security. The key findings summarized on the following pages show that we still have significant progress to make in order to secure ourselves from today's threats.
Research Report


text:
Natural Calm Canada's magnesium citrate powder features a proprietary process that provides the most absorbable, effective, fast-acting magnesium available anywhere. The 100% water-soluble magnesium citrate becomes ionic when dissolved in very hot water and can relieve many symptoms associated with magnesium deficiency quickly and effectively.
Available in a variety of flavours and sizes:
Plain (Original), Raspberry Lemon, Sweet Lemon, Orange and Cherry
8 oz (226g) and 16 oz (454g) sizes
Also available in boxes of 30 single serve envelopes in convenient Travel Packs
Directions for Use: Pour about ½ cup slightly cooled boiling water, or very hot water into a cup or glass. Add powder, let fizz, stir. Add to favourite hot or cold beverage, or enjoy like a cup of tea.
Ingredients: Magnesium Carbonate.
Non-medicinal ingredients: Citric Acid. Flavours contain organic stevia.
Mechanism of Action: The citric acid combines with magnesium carbonate to create magnesium citrate, the most absorbable form of magnesium available.
Nutrient Value, per 1 teaspoon: 205mg of magnesium
Recommended Dose to prevent Magnesium Deficiency:
Men: 2 teaspoons in very hot water provides 100% of the daily requirement of 420 grams
Women: 2 teaspoons in very hot water provides 120% of the daily requirement of 320 grams
Known Adverse Reactions: Some people may experience diarrhea. Resolve by reducing dose and taking twice a day. Note comfortably loose stools are an indication of the optimal amount. Adjust as required.
Health Canada Natural Product Licence Number: 80013188


text:
You are a fan of 2000 influenced ? Come to discover the best forums 2000 influenced on the internet and share your experience with a community fan of 2000 influenced . You can also build a forum 2000 influenced and create your online discussion.
You've been summoned by Kritch Telsmas to the world of Siltrine. Players from worlds unknown gather to find out who will clear all 2000 floors and become a Master.
siltrine, game, worlds, you've, summoned, kritch, telsmas, world, players, unknown, gather, clear, #2000, floors
Forum : Best Media Karaoke System Chinese and Vietnamese Ultimate Karaoke System. Best Media is a leading consumer electronics manufactures in wireless home entertainment and digital electronics.
forum, best, media, karaoke, system, chinese, vietnamese, electronic, entertainment, taiwan, bestmediausa, bm-2000, bm-3000, bm2000, bm3000, technical, support
Music topics archiving back to 2000.
This is a private forum to discuss the Greater Spiritual Aspects of God
This is for Legacy 2000 students that need ideas for a log.
This is my site about weatherstar & weatherscan emulators
weatherstar, weatherscan, emulators, download, 3000, 4000, intellistar, local, 1000, #2000
An abandoned location for storing Freddy Fazbear's Pizzeria unwanted creations is now filled with lively robots, what events will unfold? A roleplay forum influenced by a game series, Five Nights at Freddy's, made by Scott Cawthon.
night's, roleplay, abandoned, location, storing, freddy, fazbear's, pizzeria, animatronics, filled, lively, robots, stories, unfold?, fnaf, owned, scott, cawthon