text:
The largest casting on Earth! 1570 models, 18-65 years old! Unlimited access... Watch and download all movies, nothing more to buy! Czechcasting.com
Absolutely no censorship and certainly no fiction. These are real Czech streets! Czech girls are ready to do absolutely anything for money. Unlike other sites with similar themes, where the action is scripted and fake, this is the real thing. Authentic amateurs on the street! Theyre amazing, but they are not exactly well off. A low standard of living is probably the main reason why local girls are famous for doing unbelievable things in public... If you dont believe us, come and see for yourselves. Enjoy Czechstreets.com
The unexpected has become reality! Czech streets are not a safe place to roam anymore! A young couple with a camera approaches other Czech couples and offers them money for sex! Right on a street! An innocent chat ends up with wild fucking in the public. Amateurs are first jolted when the couple offers them that they would join them. A foursome in the public! Everyone is fucking with everyone. This is the ultimate perversity! This is a world primacy! Money, emotions, and fidelity testing. Not everybody can cope with it and good smacks land on cheaters faces! Czech couples are fucking right on the street! They would do anything for money! This is pure reality! The mind boggles. czechcouples.com
Put an end to your daydreaming. Stamp your futile fantasies. Face the reality and enter the House of Pleasure. The one and only!!! There is only one rule: Pay Choose Use! Choose a hole! Everything is available. Juicy mouths. Wet pussies. Narrow buttholes. Sucking off. Eating out. Fucking. All holes are here for you. Gorgeous girls and mature women, Czech amateurs who came here to offer all their holes. All waiting to be used. Crowds of horny guys fuck them like there was no tomorrow! This place is real! Come, pay and make your dreams come true! Czechfantasy.com
The biggest home orgy you can find. Hundreds of people in real apartments. Parties full of booze, free of scruples. Everybody is welcome, everybody is free to do anything he or she desire. Discover the world of secret parties in the Czech Republic!! Come and join the party where everybody seeks pleasure, where people know no shame. This is a real ORGY!!! We are CZECH AV and we stick to our credo: No script, no fakes! This is reality! Czechhomeorgy.com
Shocking revelation! Unbelievable! We have three spy cameras in a massage salon. We spy on Czech girls during a massage. They have no idea they are being watched. You will be shocked when you see what is going on inside! Almost every massage ends with fucking! Real footage! Czech amateurs fuck the masseur! We caught them red-handed here is the proof! You wont believe your eyes! Watch the shocking reality! You won find anything like this anywhere else! Czechmassage.com
3,500,000,000 men dream of this. Only one can experience this! Personal Harem! The world premiere. Dozens of lovely Czech amateurs and one man! The luckiest man in the world! Brunettes, blondes, redheads. Young and mature. Slim and busty. All beautiful! All horny! One guy and a group of horny women ready to do just anything to make him happy! The biggest reversed gangbang of all times!!! All for one, all on one! Not even real sultans get so much pussy! Czech Harem is the dream of every man coming true in the brightest colors! Once again, we are the first, so sit down, relax and get ready for something beyond your wildest imagination. Czechharem.com
We are changing the history!!! Nobody has filmed anything like this before!!! Heres an exclusive expedition into the life of Czech prostitutes. Absolutely new!!! Fantastic CZECH BITCH!!! A guy sets off in a car full of spy cameras to get some real Czech hookers. He hunts for them by the road, on car parks. He fucks them in the car in front of hidden cameras. Youll see sex for money like if you were there. The whores have no idea they are filmed! You will get so close you will feel like almost touching them. Czech sluts do absolutely everything for money!!!! Are you ready for the wildest ride of your lives? Hop in then. Czechbitch.com
The Czech porn star factory. You may know many of these gorgeous women from porn, but this is where it all started, their very first video, their entrance into the world of erotica. The girls have no experience with filming and no idea what to expect. The other things they have in common are their craving to become a well-known porn star and the determination to do whatever it takes. Watch the complete backstage from arrival to the sweet end and see for yourself how porn stars are made. Czechfirstvideo.com
The ultimate experience! Reality of Czech streets in its purest form! Forget everything youve ever experienced. This is a masterpiece! The wildest sociological experiment of all times. Steaming hot Czech chicks approach guys on the street offering them a quickie! Fast! Flat out! Fucking an anonymous chick right on the spot! Everything is filmed with a hidden cam. All blokes are flabbergasted! Screwed by a nameless stunner! This is outrageous public nuisance! No questions. No feelings. Sex in its most authentic form! Wicked! Czechexperiment.com
Finally!!! The first real hidden WC camera!! And not only one, we offer you 3 spy cameras in one bathroom!!! One camera is placed directly in the toilet bowl!! Now you can finally see what girls do in the bathrooms and why does it take them so long! This is UNBELIEVABLE!! We break all taboos!!! Trust me, this is something you have to see, its more than worth your time. WC CAMERA FOR REAL - NEVER BEFORE SEEN!! Czechtoilets.com
This is the world premiere! A hidden camera in a womens sauna! Smoking hot bodies of Czech beauties. Infiltration into a top secret area. Nobody before us had had the balls big enough to break all the moral rules. A secret peep-hole into a womens sauna. This is a dream come true of all voyeurs. A real sauna, real amateurs. Snooping into privacy was never this exciting. This is the most authentic form of voyeurism ever! Your rocks will be burning hot. We are the first in the world! Czechsauna.com
We put spy cameras into a real taxi in Prague. You wont believe your eyes! Lets take a look at Czech girls fucking the taxi driver. They have no idea cameras see everything. Shocking and kinky. Sex in exchange for lift. Young girls from discos, married ladies with grocery. This taxi never drove a woman for free, its gas or ass. You bet!!! The reality of Prague taxi filmed on hidden cameras! Real amateurs! Nothing is scripted! You have never seen anything like this. Just get in and enjoy the ride. Czechtaxi.com
We are the first in the world to use this revolutionary technology! The best POV ever! This will take you directly into the action. Completely realistic experience! There is nothing better! The glasses offer a perfect cover! Girls around have absolutely no idea they are being filmed! They do not have to act and they know no limits! They say everything and do even more! We spy on them everywhere! Parties, discos, streets, schools, public transport, sport, cinema, just everywhere! Spying knows no limits! You will see amazing Czech girls like you really were there. The world of porn is changing now and forever! Czechspy.com
A huge party with the most beautiful Czech girls. You will never see anything like it, there is just no competition! Real models as well as beautiful amateurs, smashed and ready to do anything for the right price. Every evening has a specific theme: big boobs, eighteen year olds, secretaries, students and much more... The girls are served free booze and our cameramen try to convince them to have sex for money. Everything is authentic and none of the girls know what is going to happen! Czechparties.com
We discovered something unbelievable! Worlds first brothel for poor!!! And you will see all the shocking scenes thanks to our hidden cameras!! Girls in cellar on filthy mattresses, separated only by dirty rugs! For 200 CZK (about 8 USD) you can do anything you want!!! The rough pimp is watching over the whole place and keeping it running! Fuck, cum and leave! The line of horny guys is endless. This is about satisfying your lowest needs only. Would you believe such places exist? You wont believe unless you see this! This is the raw reality of Czech underground brothel!!! Czechdungeon.com
The largest lesbian group event ever. Dozens of strikingly beautiful Czech girls and women in the wildest action imaginable. Authentic amateurs - no fakes, no script! Nowhere else will you see such a concentration of gorgeous lesbians. We invite fresh, never before seen girls to every event and provide huge amounts of free booze. The results are amazing. Unbelievable orgies that go on for hours! These girls sure know how to have fun... Although men are not allowed, you can at least watch the amazing videos. Enjoy Czechlesbians.com
The miracle of female orgasm. A unique project. Gorgeous Czech girls are frigging their pussies on camera. They are revealing you their innermost secret their own way to an orgasm. Scenes showing genuine climax! Unparalleled! Incredible! You have never been so close. Massive orgasmic explosions right in front of you! Can you feel it? The power of orgasm! Dare to explore it! Czechorgasm.com
This may be one of our most audacious projects to date. Our special field agents scout out the best locations in various Czech cities and then proceed to jump and "shark" the prettiest girls they can find. Skirts and shirts fly off their beautiful bodies and they are left standing there in awe as a camera gets a good long view of their exposed charms. We do not have to emphasize that as far as we know, all these girls are complete amateurs. No scripts, no fakes, just real action right there on the street. Warning: Never try the things you will see in this video! Czechsharking.com
The world premiere!!! Heres the first hidden camera in solarium!! You havent seen this before! We spy on girls in public solarium using two secret cameras. You will be shocked to see what they do during tanning. One of the cameras is on the best spot INSIDE THE SOLARIUM!!! And things do happen there!!! Nobody is able to offer you this! We breached into the privacy of Czech girl. Real footage from a spy camera in solarium. The first one in the world! Unbelievable!!!! Czechsolarium.com


text:
Stunning Upper Hillsborough Contemporary home 4,338 sq ft.living space(per report)& an impressive lot 43,429 sq.ft(percounty). This welcoming home offers updated and generously size 4 bedrooms & 3.5 baths, high ceilings,natural light filled floor plan and top of the line finishes with high end appliances. The rich hardwoodfloor throughout,thick moldings, French doors from almostevery room lead to terrace and walled balconies. Chefs dreeam kitchen,granite counters w/center island which holds Wolf cook top can hold six diners.Spacious garages holds 3 cars and extra storage.
上市日期: 2016年7月25日

subset: commoncrawl


text:
About iPage: A web hosting leader, iPage serves more than 1 million customers on the web. Novices will find these tools incredibly user-friendly. This secure network infrastructure is competent and ready to build you a presence on the internet. For business or (read more)
Free Online Store.
Redeemed: 107 times
Free Search Engine and Marketing Credits.
Redeemed: 127 times
Free Drag and Drop Builder.
Redeemed: 114 times
Free Domain Registration, Free Setup, Free Support -- All risk Free.
Redeemed: 93 times
Free Domain Registration.
Redeemed: 86 times
30-day Money Back Guarantee.
Redeemed: 29 times
Don't you wish you could turn back time? These deals have already expired, but some coupons work beyond their expiration.
75% off regular price 24-month plan and 72% off 36-month plan.
Redeemed: 166 times
75% off Regular price 24-month Plan and 72% off 36-month Plan through this link.
Redeemed: 123 times
75% off 24-month Plan or 72% off 36-month Plan.
Redeemed: 161 times


text:
This page contains Cheats for One Piece: Romance Dawn - Bouken No Yoake organized by sections for PSP. This game has "Role-Playing" as genre, made by Bandai Namco Games, released on Dec 20, 2012. If you can't find a hint or secret in our list, then please check this page periodically for the latest updates.
- Developer: Bandai Namco Games
- Publisher: Bandai Namco Games
- Genre: Role-Playing
- Release: Dec 20, 2012
- ESRB: Not Set
If you know cheat codes, secrets, hints, glitches or other level guides for this game that can help others leveling up, then please Submit your Cheats and share your insights and experience with other gamers.
Help me reach lvl 99 so that i will finish my game...
Stuck in this game? Set a specific, clearly defined question and let other gamers answer your question or view answers to previously asked questions. If you think you are an expert then please try to help others with their questions.
One Piece: Romance Dawn - Bouken No Yoake - Story Line Trailer
- Added on: Jul 5, 2013
One Piece: Romance Dawn - Bouken No Yoake - Official Launch Trailer
- Added on: Feb 17, 2014
- Retro City Rampage: DX, (PSP)
- Angus Hates Aliens, (PSP)
- Meiji Toukyou Renka: Twilight Kiss, (PSP)
- Yoiyomore No Hime, (PSP)
- Harukanaru Toki No Naka De 6, (PSP)
- Kaleidoeve, (PSP)
- Yu-Gi-Oh! ARC-V Tag Force Special, (PSP)
- Brandish: The Dark Revenant, (PSP)
- Grisaia No Rakuen: Le Eden De La Grisaia, (PSP)
- Shinobido: Tales Of The Ninja, (PSP)
- 7th Dragon 2020, (PSP)
- Ultraman Fighting Evolution 0, (PSP)
- Yu-Gi-Oh! GX Tag Force 2, (PSP)
- Lego Star Wars 3: The Clone Wars, (PSP)
- Yu-Gi-Oh! ARC-V Tag Force Special, (PSP)
- Assassin's Creed: Bloodlines, (PSP)
- Patapon 3, (PSP)


text:
In Adoption news, we learned last week Friday that we aren't leaving "any day" to bring the kids home. The Embassy over there would like a bit more information before issuing visas. This isn't all that unusual, just a bit disappointing. We know that they will join this family physically at the perfect time, God's time, not a minute too soon or late. We're told we should hear something in about 8 weeks. We're getting so very anxious!
On a more humorous note, here's a funny story for you: Yesterday, Chris and I were cleaning up after dinner and The Littles were playing together in the living room. They were a bit giddy because we were all going to play outside after the dishes were done (I know...simple pleasures...). Chris told them to find something to do for a few minutes and then we'd head outside. In deciding what to do for those few minutes Hanna offered a suggestion, "Hey Drew, want to play Lazarus? You can be Jesus". Chris and I were absolutely ROLLING in the kitchen! I don't think Drew had a clue what she was talking about but in true Drew fashion he agreed, so off they went. Hilarious. We'll be laughing about that one for a long time I think.


text:
Grand Villa Hotel, a beautifully designed hotel in the commercial capital of India provides plethora of services. It facilitates all its guests with 24-hour front desk, luggage storage, and complimentary newspaper in lobby, laundry facility, 24-hour room service, complimentary internet access, free parking facilities, restaurant, doorman, security guard and much more. Grand Villa Hotel is a smoke-free property.
Attractions travelers recommend


text:
to save this item to your jcp.com account
Chef's Choice® Cordless Electric Glass Kettlepp5005310216
web ID: 7802360
Beautifully crafted from heat-resistant glass and brushed stainless steel, this electric kettle is perfectly shaped for quick and easy heating and pouring.
- contemporary cordless design, comfortable ergonomic handle and single-hand, push-button lid opening allows it to easily lift from the base for easy filling, pouring and serving
- concealed heating element efficiently delivers 1500 watts of power and will boil water faster than a stove or microwave oven
- automatic shutoff when water boils and boil-dry shutoff protection
- water level gauge is ideal for right- or left-hand use
- illuminated on-off switch
- cool-touch bottom
- adjustable cord stores neatly in the base
- takes up minimal counter space
- 1½-quart capacity
1500 watts. AC. Stainless steel/glass. Measures 8.88x6.75x9.5"H. Hand wash removable kettle. Imported.
Rated 5 out of 5 by Peggy from Use it daily We already have this same product in our kitchen. My husband and I use it every day to heat water up for tea. My husband wanted another one for himself to use upstairs when he has a cup of decaffeinated tea before bed. The water heats up fast and the carafe comes away from its pedestal without dragging a cord with it.
Date published: 2016-12-07
Rated 5 out of 5 by Tealover from This product is what I have been looking for. This product makes my life easier. It will turn off automatically which makes it easier for me.
Date published: 2016-12-27
Rated 4 out of 5 by teakhai from spending this much money to boil water is nuts, but it is a great kettle Who would have thought that watching water boil could be so addicting?
Date published: 2015-11-21
true1 year small appliance protection plan $7 manufacturer shipped (ships in 3 week(s)),MS3W
No additional protection
Same Day Pickup items ordered after 3 p.m. will be available the next day.
to save this item to your jcp.com account


text:
To ensure continuous
learning for each student.
District Vision
Educating our students
for the challenges of tomorrow
District Mission
Providing an exemplary education for all learners
For an update on the status of the sinking fund projects to date, click this link.
Head Start Band for students entering 6th grade in the Fall
Band Workshop for students enrolled in 7th & 8th grade band this Fall
Lake Orion students in middle and high school can now register for summer learning classes. A variety of options are available, including credit recovery and credit foward programs, special middle school options and Algebra Readiness. CLICK HERE to access more details on the summer program and registration forms.
There's plenty to read in the Spring 2017 edition of Dragon News, from plans for the District's open houses next month to the successful state student council conference hosted by Lake Orion's leadership class to Teachers-of-the-Year and hot career paths in Oakland County. There's also more teacher accolades, robotics team news, band and choir honors, Battle-of-the-Books results and the new Wall of Excellence at LOHS. Finally, see how the District celebrated March is Reading Month and the impressive high school graduation rate, plus winter sports summaries and pictures from around the District. CLICK HERE to read it!
Lake Orion elementary, middle school and high school calendars for the 2017-18 school year are now available. CLICK HERE
Testing Schedule
8th grade April 19 - April 25
7th grade May 8 - May 11
6th grade May 15 - May 17
Parent Letter
Lake Orion Community Schools is now accepting applications for out-of-district students in kindergarten through eighth grades, as well as Learning Options High School, for the 2017-18 school year through May 9, 2017. For more information, CLICK HERE or visit Go2LO.com.
In an effort to assist parents with the transition of their children to new schools next year, Lake Orion's elementary family school coordinators and middle school counselors held a district- wide presentation on February 22 at the high school called "Helping Your Child Manage Change". CLICK HERE for a copy of the presentation given and other resource information that were distributed to persons in attendance.
The start and dismissal times for Lake Orion's elementary schools, middle schools, high school and Learning Options program for 2017-18 have been released. CLICK HERE for the full-day and half-day schedules for each building. SACC (latchkey) will open to students at 6:30 a.m. and close at 6 p.m.


text:
Free UK Delivery on Orders Over £75 (Excludes food orders)
Vackertass Dog Bow Tie in Green
A beautiful tartan print dog bow tie made with 100% cotton, by Vackertass Supply Co. These bow ties come in one size, and are easily attached to different collar widths thanks to double sided velcro (soft side against your dog's neck).
All items are handmade and unique so patterns may vary.
About the brand:
Vackertass Supply Co was started in 2016 by former concert photographer Annelie Rosencrantz. All products are original designs, which are handcrafted with love from their studio in Walthamstow, London, UK.
Size details:
The bow tie measures approximately 10cm wide and 5cm tall. Will fit up to 3cm wide collars.
How to care for me:
Gentle hand wash with cold water or spot cleaning when needed.
Related productsView all
Kong Ball Extreme Dog Toy in Black
From £7.49
Kong Traxx Dog Toy
From £9.49
Kong Goodie Bone Dog Toy
From £5.89
Scruffs Cool Mat
From £19.99
Air Kong Disc Dog Toy
From £7.19


text:
5 in another and you are placing your bet on Duke, it is best to place the bet on +6. My Separated Husband Says I'm Smothering Him And I'm Not Sure How To Stop. The all-in tricks are the do or die caesars casino online slots situation so you need to be very careful when going for this trick. Plus your chips and online slots with money glasses could damage the table top or ruin the finish. A SIM card holds your unique information, such as, the International Mobile Subscriber Identity (IMSI), your mobile SIM card identification, your calling plan, etc..
Your new found abilities may just lead you into directions you may not expect!Your next bet will have to be caesars casino online slots quite large if you plan on continuing with the aggression, and that's when you can expect the shark to raise. It is the strongest possible pre-flop hand in play online stinkin rich slots Texas Holdem Poker. I use one method consistently caesars casino online slots when reviewing a MLM opportunity. The little power adapter instant play slots online connection will go directly into your Roku electrical power input and so the opposite end obviously will go best casino slots vegas into the wall electrical socket. If you are a regular online shopper, then there is ample opportunity for you to earn money back on your purchases..
Many people consider Benny as the man responsible for introducing poker in casinos and making it immensely popular. If slots nuts casino no deposit bonus codes you think that one strategy is failing, just start thinking about second strategy and if not, apply third. In the end, superstitions can help a person feel more confident and secure when placing his bets while also giving him a scapegoat in case things do not go according to plan. Ideally, you should be the only caesars casino online slots tight aggressive player at a table. Certainly, there is play slots on your phone no system that predicts the winning numbers for the next spin caesars casino online slots with a 100% certainty, because casinos would have gone out of business by now. You can either keep your money in your pocket or you can consider the possibility of following a professional handicapper. Pitting your wits against other hard rock casino online slots players in a mind game of cat and mouse with the skilled player coming out on top adds to the unique appeal of poker..


text:
This is the full research report for 220.127.116.11, which is an IP address.
Administered by APNIC
NTT Communications Corporation
1-6 Uchisaiwai-cho 1-chome Chiyoda-ku, Tokyo 100-8019 Japan
Japan Network Information Center
Urbannet-Kanda Bldg 4F
3-6-2 Uchi-Kanda, Chiyoda-ku, Tokyo 101-0047,Japan
Telephone: 81352972311
Fax: 81352972312
Japan Network Information Center
Urbannet-Kanda Bldg 4F
3-6-2 Uchi-Kanda, Chiyoda-ku, Tokyo 101-0047,Japan
Telephone: 81352972311
Fax: 81352972312
220.127.116.11 is the IP address you have a ran a report for on April, 25, 2017.
If you meant to use another IP other than 188.8.131.52, then enter above and try again.
It is 10:38 PM CEST when you ran this report for 18.104.22.168 here on our website, IP-Adress.com. When it comes to 188.8.131.52, you can trust that if we have IP Whois information available for it, we will display it further below to assist in your research of this IP address. Feel free to run another search for 126.96.36.199 or a different search.
Timestamp Confirmation:
The IP Whois report for 184.108.40.206 was ran at 10:38 PM CEST on April 25, 2017 and the information is provided below if available.
View comments on this 126.96.36.199 Whois IP address report below or add your own comment about 22.214.171.124.
Now you can review additional IP Whois data for 22.214.171.124 below. Things like the status of 184.108.40.206 and the server of 184.108.40.206.
Don't forget that the server that hosts 18.104.22.168 could also host other IP addresses, so research accordingly.
|Hello guest sign up now!
Remaining lookups today: 38 (Get more)
My IP is: 188.8.131.52


text:
Extending from 155th Street to Dyckman Street, Washington Heights is home to some of the most interesting geographic features in Manhattan.
The neighborhood's lofty name is derived from the fact that—at 256 feet above sea level—it is situated at the highest point in Manhattan. Because of its steep inclines, numerous "step" streets (one of which has 130 stairs) connect one street to the next.
The population of Washington Heights is over 150,000.learn more about this neighborhood
#51Neighborhood popularity:based on Naked Apartments searches
Building Mix
- 37% Pre War
- 27% Elevator/Laundry Building
- 18% Elevator Building
- 12% Walk-Up
- 2% Post War
Legal Disclosure: Neighborhood descriptions and data are created exclusively by Naked Apartments without contributions or approval from the agents listed on this page.
Pinehurst Avenue by Petri_Krohn is licensed under CC BY-SA 3.0
TERRIFIC!! **NO FEE** + 1 month Free! HIGH END LUXURY HUGE 4BR on St Nicholas Avenue. Gut Renovated Apt! in elevator building! State of the art stainless steel appliances, Granite counter tops, DISHWASHER! Amazing New Bamboo hardwood floors throughout, amazing fixtures all through the apartment, ceiling fans, marble bath and kitchen, New security system, very close to Columbia Univ Hospital, City College. Has a live in super, laundry in the basement. Call NOW! these go QUICK!!
Apartment Details
$3,150, Four Bedrooms, 1.0 Bathroom
No fee
Last Updated ~ 4 Years
Listed For ~ 4 Years
Available Immediately
Pets: Pets Allowed
- 0 sq. ft.
- Web ID: NKA_LevelGroup_31822
Dishwasher, Elevator
Nearby Subway Stations
C163rd St (0.08 mi)
C155th St (0.24 mi)
1157th St (0.26 mi)
B155th St (0.31 mi)
A C 1168th St (0.46 mi)
3148th St (0.7 mi)
A C B D145th St (0.75 mi)
1145th St (0.77 mi)
A175th St (0.86 mi)
3145th St (0.97 mi)


text: Iphone 6s Rear Facing Camera - Topyet Electronic Co.,ltd Toggle navigation TRADE DEALS Products Companies Product Company Search LOGIN E-mail Password Remember me Join Free JOIN FREE HomeConsumer Electronics Camera & Accessories Iphone 6s Rear Facing Camera PRICE: contract price Product Description As one of the famous iphone 6s rear facing camera manufacturers and suppliers in China, Topyet Electronic Co.,Ltd is also a professional customized iphone 6s rear facing camera exporter, welcome to buy or wholesale products from our factory.iPhone 6s rear facing cameraFeatures: This iPhone 6S Rear Facing Camera does not include the camera lens.This is the iPhone 6S Rear Facing Camera. We can also supply the iPhone 6S Front Facing Camera.This iPhone 6S Back Camera is a brand new original replacement.Description: This brand new high quality iPhone 6s Rear Camera Replacement will repair issues with the 12 MP primary or rear camera on your smart phone. Do not tolerate inability to focus, scratched lens, or loss of any of the cameras great functions. Replace it and your picture taking will be sensational again. This low cost solution and the right repair tools is all you needProduct nameiPhone 6s rear rear cameraPixels4032*3024 pixelsCompatible modelApple iPhone 6s rear camera replacementTrade termsFOB.ConditionOriginal newShipmentDHL,UPS,Fedex or EMS to all over the world Other products Iphone 6s plus vibrator motor Price: contract price Iphone 6s plus wifi antenna flex cable Price: contract price Iphone 6s plus power button flex cable Price: contract price Oem assembly lcd screen for iphone 5s Price: contract price Company Info Topyet Electronic Co.,ltd Contact Person: Hui Zhou Phone: 86-0755-23946717 Contact now × Contact form Your name: Your E-mail: Your Phone: Subject: Enter a message: Close


text:
box office 01497 822 629
The full programme is available for this year's festival, 25 May to 4 June - you can download a PDF of the programme here. We very much look forward to seeing you in May.
Join our mailing list for regular email updates and follow us on twitter @hayfestival
Click here to see a list of sold out events
Rhyd Lewis
The Mathematics of Networks and Maps - Cardiff University Series 2
Event 215 • • Venue: Llwyfan Cymru – Wales Stage
How do satnavs find the quickest route from one town to another? What's the most efficient way to visit the best pubs in the UK? Is it true that all living things in the world are six or fewer degrees of separation away from each other? The Cardiff mathematician shows, pictorially, how the many problems in everyday life can be modelled as networks: from the colouring of maps to the way Facebook makes friend recommendations.


text:
Most Earned
Least Earned
Discounts on Destiny, Grand Theft Auto V, Halo 5: Guardians, Fallout 4, Assassin's Creed IV: Black Flag, Star Wars Battlefront, Call of Duty: Black Ops III and more
Posted 13 days ago by Rich Stone, 174 comments
The second week of the Countdown to 2017 sales brings us another massive list of discounts, including big recent releases and some older titles.
Posted 4 months ago by Chewie, 67 comments
This week we get a number of fairly large sales running simultaneously including a Gears & Forza based Deals with Gold, a large Activision publisher sale, discounts on Star Wars Battlefront (including the Season Pass!) & more
Posted 8 months ago by Chewie, 67 comments
Marvel Ultimate Alliance is the highlight of the week. There may well be a lack of new titles, but there's plenty of DLC to make up for it.
Posted 9 months ago by Rebecca Smith, 14 comments
The successor to the original Xbox/PS2/GameCube era's X-Men Legends series, the Marvel Ultimate Alliance games garnered a fan base on Xbox 360. Marvel has announced it will be releasing current-gen versions next week.
Posted 9 months ago by Kelly Packard, 147 comments
community members have subscribed to receive updates for this game.
There is currently no walkthrough for the Marvel Ultimate Alliance 2 achievements. Interested in creating one? Click here for more details.
Copyright © 2017 TrueGaming Network
Ltd, All Rights Reserved
Xbox, Xbox Live, and all other Xbox Live specific terms are registered trademarks of Microsoft Corp.
TrueAchievements is a proud member of the Xbox Community Developer Program
Concept, Design, Programming and Server Stuff by Rich Stone
aka TrueAchievement
Available on Mobile


text:
+90% Off SelectSimone Rocha Handbags
SIMONE ROCHA Handbags. medium, polished leather, solid color, no appliqués, framed closure, removable handle, contains non-textile parts of animal origin, clutch bags. Soft Leather
Simone Rocha Knotted leather clutch
Simone Rocha's pale-pink clutch has a distinctive knotted handle – a detail first seen on the SS17 runway. It's crafted from supple leather and features a full zip closure to keep the contents inside secure. It looks at home with one of the designer's striking dresses, but will work equally well with minimalist pieces.
Simone Rocha Knotted leather clutch
Knotted bags, just like this black leather clutch, accompanied many of the looks on Simone Rocha's hyper-feminine SS17 runway. It's crafted to a compact bucket-style shape and can be tucked under one arm or held by the top handle. Style it with other pieces from the collection for an ensemble that's equal parts refined and directional.
Simone Rocha Knotted floral-cloqué clutch
Simone Rocha's black clutch is a contemporary way of carrying small essentials throughout the evening. It's crafted from a textured cloqué that's decorated with a tonal-red, yellow and green peony print, and has a half-moon shape that's held by knotted ties. Keep your mirror, lipstick, and smartphone in the compact interior.
Simone Rocha Knotted taffeta bag
Many of the hyper-feminine looks on Simone Rocha's SS17 runway are accompanied by unexpected accessories – this black bag included. It's crafted from taffeta for an unstructured feel, and shaped with directional knots at the side and top handle. Carry it in one hand, or slouch it in the crook of your elbow.


text:
1/3 cup (75 mL) pot or pearl barley
1/3 cup (75 mL) wild rice
2 cups (500 mL) beef, vegetable or chicken broth, divided
1/3 cup (75 mL) brown rice
¼ tsp (1 mL) pepper
In a medium saucepan, combine barley and wild rice with half of the broth; bring to a boil. Cover, reduce heat and simmer for 25 minutes. Add brown rice and remaining broth. Continue to simmer for 25 minutes, adding additional broth or water, if necessary. Season to taste with pepper.
Makes 6 servings.
Nutritional Information (per serving):
Calories: 114
Protein: 4 g
Carbohydrate: 23 g
Fibre: 3 g
Sugars: 0 g
Fat: 0.5 g
Saturated Fat: 0.1 g
Trans Fat: 0 g
Cholesterol: 0 mg
Sodium: 299 mg
Potassium: 93 mg


text:
Тема обращения:
Описание проблемы:
Введите почтовый адрес:
Войти в систему
Интеллектуальная Система Тематического Исследования НАукометрических данных
|Spectral dependence of the optical rectification effect in nanographite films / G. M. Mikheev, R. G. Zonov, A. N. Obraztsov et al. // Technical Physics Letters. — 2005. — Vol. 31, no. 2. — P. 94–96. The spectral dependence of the optical rectification effect in nanostructured carbon (nanographite) films obtained by plasmachemical deposition was studied in a wavelength range from 266 to 1900 nm. In this range, the amplitude of the electric signal observed when films were irradiated by nanosecond light pulses of constant power increases in inverse proportion to the laser wavelength. The experimental results confirm the assumptions made previously concerning the mechanism of the observed effect. It is suggested that nanographite films are promising materials for detectors of ultrashort laser pulses in the IR, visible, and UV spectral intervals and for generators of electromagnetic radiation operating in the terahertz frequency range. (C) 2005 Pleiades Publishing, Inc. [ DOI ]


text: Seller: ad-ac.motoerwelt (83) 100%, Location: Germany, Ships to: Worldwide, Item: 152211597507 TWO VERY rare, spectacular, ORIGINAL 1960s Kinkeldey "Golf" sconces/wall lights. Chromed, solid brass, cut crystal glass; two, solid, chromed brass bulb holders each (see pictures); fully functional (see pictures). Solid, HIGHEST quality workmanship. Perfect condition (see pictures). Dimensions (ca.): Height: 10,24" (26 cm.), depth: 9,06" (23 cm.). Several manufacturer signets (see pictures).Note: These sconces are new (from old stock). They was never been mounted (for the pictures we've hung them up on shoelaces; see pictures) and come in their original packaging (see pictures). The "Golf" sconces are, by far, the rarest pieces from the Kinkeldey series; as far as to be seen there are no further identical objects in the international market at the moment. FREE packing (double and safe), handling and shipping. Condition: New; old stock - unused...., Original/Reproduction: Original


text:
Optical interconnects are progressively replacing wires at shorter and shorter distances in information processing machines. This paper summarizes the progress toward and prospects for the penetration of optics all the way to the silicon chip.
© 2010 Optical Society of AmericaFull Article | PDF Article
OSA Recommended Articles
Berkehan Ciftcioglu, Rebecca Berman, Shang Wang, Jianyun Hu, Ioannis Savidis, Manish Jain, Duncan Moore, Michael Huang, Eby G. Friedman, Gary Wicks, and Hui Wu
Opt. Express 20(4) 4331-4345 (2012)
Guoqiang Li, Dawei Huang, Emel Yuceturk, Philippe J. Marchand, Sadik C. Esener, Volkan H. Ozguz, and Yue Liu
Appl. Opt. 41(2) 348-360 (2002)
Gökçe I. Yayla, Philippe J. Marchand, and Sadik C. Esener
Appl. Opt. 37(2) 205-227 (1998)


text:
|Publication number
|Publication type
|Application number
|Publication date
|Jun 26, 2012
|Filing date
|Feb 5, 2010
|Priority date
|Feb 5, 2010
|Fee status
|Also published as
|Publication number
|Alexander A. Makarov, Eloy R. Wouters
|Original Assignee
|Thermo Finnigan Llc
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (37), Non-Patent Citations (31), Referenced by (12), Classifications (17), Legal Events (2)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention relates to ionization sources for mass spectrometry and, in particular, to a nano-electrospray ionization source comprising a surface having a plurality of protruding microscopic to sub-microscopic pillars, cones, needles, or wires each of which acts to emit ions from an analyte-bearing liquid applied to its exterior surface.
The well-known technique of electrospray ionization is used in mass spectrometry to produce ions. In conventional electrospray ionization, a liquid is pushed through a very small charged capillary. This liquid contains the analyte to be studied dissolved in a large amount of solvent, which is usually more volatile than the analyte. The conventional electrospray process involves breaking the meniscus of a charged liquid formed at the end of the capillary tube into fine droplets using an electric field. The electric field induced between the electrode and the conducting liquid initially causes a Taylor cone to form at the tip of the tube where the field becomes concentrated. Fluctuations cause the cone tip to break up into fine droplets which are sprayed, under the influence of the electric field, into a chamber at atmospheric pressure, optionally in the presence of drying gases. The optionally heated drying gas causes the solvent in the droplets to evaporate. According to a generally accepted theory, as the droplets shrink, the charge concentration in the droplets increases. Eventually, the repulsive force between ions with like charges exceeds the cohesive forces and the ions are ejected (desorbed) into the gas phase. The ions are attracted to and pass through a capillary or sampling orifice into the mass analyzer.
Incomplete droplet evaporation and ion desolvation can cause high levels of background counts in mass spectra, thus causing interference in the detection and quantification of analytes present in low concentration. It has been observed that smaller initial electrospray droplets tend to be more readily evaporated and, further, that droplet sizes decrease with decreasing flow rate. Thus, it is desirable to reduce the flow rate and, consequently, the droplet size, as much as possible in order to obtain mass spectra with minimal background interference. Nano-electrospray, with flow rates per emitter in the range of less than several hundred nanoliters per minute to 1 nanoliter per minute, has been found to yield very good results, in this regard. Further, it has been found that the efficiency of ionization is much higher in nanospray mode and that the response is more linear than in other spray modes. For instance, Ficcaro et al., in a technical paper titled "Improved Electrospray Ionization Efficiency Compensates for Diminished Chromatic Resolution and Enables Proteomics Analysis of Tyrosine Signaling in Embryonic Stem Cells" (Analytical Chemistry 81, 2009, pp. 3440-3447), demonstrate that, in the assessment of LCMS performance, the improved electrospray ionization efficiency at low flow rates outweighs deterioration of chromatographic separation, even at chromatographic flow rates below Van Deemter minima. However, conventional electrospray devices and conventional liquid chromatography apparatuses which deliver eluent to such electrospray devices are typically associated with flow rates of several microliters per minute up to 1 ml per minute.
Attempts have been made to manufacture an electrospray device which produces nanoelectrospray. For example, Wilm and Mann, Anal. Chem. 1996, 68, 1-8 describes the process of electrospray from fused silica capillaries drawn to an inner diameter of 2-4 μm at flow rates of 20 nl/min. Specifically, a nanoelectrospray at 20 nl/min was achieved from a 2 μm inner diameter and 5 μm outer diameter pulled fused-silica capillary with 600-700 V at a distance of 1-2 mm from the ion-sampling orifice of an Atmospheric Pressure Ionization mass spectrometer. Other nano-electrospray devices have been fabricated from substantially planar substrates with microfabrication techniques that have been borrowed from the electronics industry and microelectromechanical systems (MEMS), such as chemical vapor deposition, molecular beam epitaxy, photolithography, chemical etching, dry etching (reactive ion etching and deep reactive ion etching), molding, laser ablation, etc.
In order to realize the aforementioned benefits of nano-electrospray at higher overall flow rates, electrospray arrays of densely packed tubes or nozzles have been developed, using either capillary pulling or microfabrication and MEMS techniques, so as to increase the overall flow rate without affecting the size of the ejected droplets. For example,
A grid-plane region 12 of the ejection surface 10 is exterior to the nozzle 9 and to the recessed region 11 and may provide a surface on which a layer of conductive material 14 including a conductive electrode 15 may be formed for the application of an electric potential to the substrate 5 to modify the electric field pattern between the ejection surface 10, including the nozzle tip 9, and the extracting electrode 54. Alternatively, the conductive electrode may be provided on the injection surface 8 (not shown).
The electrospray device 4 further comprises a layer of silicon dioxide 13 over the surfaces of the substrate 5 through which the electrode 15 is in contact with the substrate 5 either on the ejection surface 10 or on the injection surface 8. The silicon dioxide 13 formed on the walls of the channel 6 electrically isolates a fluid therein from the silicon substrate 5 and thus allows for the independent application and sustenance of different electrical potentials to the fluid in the channel 6 and to the silicon substrate 5. Alternatively, the substrate 5 can be controlled to the same electrical potential as the fluid.
As shown in
All presently known nano-electrospray array devices utilize a conventional delivery method in which analyte-bearing liquid is delivered to a hollow nozzle by means of micro-capillaries or micro-tubes, so as to be emitted from an interior bore of the nozzle. There are many limitations to the use of such small-bore capillaries and nozzles, such as clogging, difficulty in producing a spray and, in the case of silica capillaries, difficult handling. Furthermore, with such conventional electrospray delivery techniques, an increase in salt concentration results in spraying difficulty and there is a sudden decline in desorption efficiency of ions into the gaseous phase. Accordingly, such delivery methods cannot be applied to NaCl aqueous solutions on the order of 150 mM, such as physiological saline solution.
In order to address the above identified limitations in the art, there are provided various methods and apparatuses for a multi-needle parallel nanospray ionization source for mass spectrometry.
In a first aspect of the invention, there is disclosed an electrospray ion source for a mass spectrometer comprising: an electrode comprising at least a first plurality of protrusions protruding from a base, each protrusion of the at least a first plurality of protrusions having a respective tip; a conduit for delivering an analyte-bearing liquid to the electrode; and a voltage source, wherein, in operation of the electrospray ion source, the analyte-bearing liquid is caused to move, in the presence of a gas or air, from the base to each protrusion tip along a respective protrusion exterior so as to form a respective stream of charged particles emitted towards an ion inlet aperture of the mass spectrometer under application of voltage applied to the electrode from the voltage source. The first plurality of protrusions may occupy an area of the electrode having a shape that corresponds to a shape of the ion inlet aperture. Various embodiments may comprise a coating layer adhered to at least a portion of each of the protrusions, the coating layer providing an increase in a tendency of the analyte-bearing liquid to be drawn towards the protrusion tips. Various embodiments may comprise an extractor electrode spaced at a distance from the electrode so as to form a gap therebetween, the extractor electrode having an aperture therein such that, in operation of the electrospray ion source, an electric field between the electrode and the extractor electrode causes a portion of the emitted charged particles to be propelled through the aperture in the extractor electrode. Various embodiments may comprise a bottom substrate adhered to a side of the electrode opposite to the protrusions so as to provide structural support to the electrode. Various embodiments may comprise a cover plate having at least one aperture therein; and a spacer disposed between the cover plate and the base of the electrode, so as to form a gap between at least a portion of the cover plate and at least a portion of the electrode, such that analyte-bearing liquid delivered from the conduit is caused to flow into the gap, wherein the first plurality of protrusions protrude through the at least one aperture.
In other aspects of the invention, there are disclosed methods of fabricating a multi-emitter electrospray electrode including the steps of: providing a substrate; exposing a first side of the substrate to a beam of accelerated heavy ions so as to produce a set of latent ion tracks within the substrate that do not penetrate to an opposite side of the substrate; exposing the first side of the substrate to a chemical etchant so as to form a plurality of etch channels within the substrate that extend into the substrate interior from the first side and that do not penetrate to the opposite side of the substrate; and depositing a layer of conductive material within the etch channels and on the first side of the substrate. Alternative subsequent steps may include either removing the substrate from the conductive material, the conductive material comprising the multi-emitter electrospray electrode or removing a portion of the opposite side of the substrate and at least a portion of the tips of the conical pillars so as to truncate a subset of the plurality of conical pillars, the truncated conical pillars comprising hollow electrospray nozzles of the multi-emitter electrospray electrode.
In yet other aspects of the invention, there are disclosed methods for providing ions derived from an analyte-bearing liquid to a mass spectrometer by electrospray ionization, the analyte-bearing liquid supplied at a total flow rate of greater than or equal to 50 microliters (μl) per minute comprising: (a) dividing the total flow into a plurality of sub-flows of analyte-bearing liquid, each sub flow providing a portion of the total flow at a rate of less than or equal to 500 nanoliters (nl) per minute; (b) providing a plurality of electrospray emitters; (c) providing each sub-flow of analyte bearing liquid to a respective one of the electrospray emitters; (d) generating an electrospray emission from each of the electrospray emitters in the presence of a gas or air; and (e) directing each electrospray emission to an ion inlet of the mass spectrometer. The gas or air, which may be at atmospheric pressure in various embodiments, may provide controllable evaporation of a solvent or aid in de-clustering between analyte ions and other particles. In other embodiments, the gas or air may be maintained at a pressure within a range of 0.03�atmospheric pressure to 2�atmospheric pressure.
Apparatus in accordance with the present teachings can comprise a material that has a large number of pillars per unit area—typically 1000-500,000 per square centimeter, corresponding to an average inter-pillar spacing in the range of approximately 6-320 μm. The tips of the pillars, from which ions are emitted when the electrode is in use as an electrospray emitter, can have a diameter of less than 1 μm. The density of pillars may controlled by controlling the duration of exposure of the substrate to the accelerated heavy ions.
Although the protrusions in this example are described as "pillars", it should be clear that, depending on form factors, semantic preferences and other circumstances, the protrusions of the electrodes described in this document may, in any particular instance, be more aptly described as "columns", "cones", "needles", "rods" or "wires". These are all various types of protrusions or protruding surfaces away from a base or away from a basal surface. The ion emitters described herein may variously be described as "protrusions", "pillars", "columns", "cones", "needles", "rods", "wires" or even "capillaries" depending on form factors, shape, materials employed, method of manufacture, or other circumstances or factors. The present teachings provide benefits, relative to the conventional art, of providing simple manufacturability and robust multisprayer devices. Instead of a single nanospray tip, as in the conventional art, the present teachings provide thousands (or more) of nanospray emitters operating in parallel. Thus, the benefits of nanospray—namely, high ionization efficiency due to the small initial droplet size—can be married to the larger flow rates, 1 μl/min-10 ml/min, of standard liquid chromatography assays. A further advantage is that the disabling or malfunctioning of a single—or even several—of the emitters has a negligible effect on the overall mass spectrometry results. Also, for those embodiments in which the sample flows on the outside of the needles, the clogging issues that occur with nanospray capillaries are eliminated.
To efficiently capture all the ions generated when using apparatus or methods in accordance with the present teachings, the atmospheric pressure ion inlet to a mass spectrometer can be modified from the traditional circular cross section to a more elongated or letter box shape, or can take the shape of an array of ion transfer tubes. The array can be linear or circular to most efficiently match the dimensions of the droplet mist. Such ion inlet modifications, when used in conjunction with ion sources disclosed herein, are expected to provide increased sensitivity relative to existing ion source/mass spectrometer assemblies.
The present invention provides methods and apparatus for an improved ionization source for mass spectrometry. The following description is presented to enable one of ordinary skill in the art to make and use the invention and is provided in the context of a particular application and its requirements. It will be clear from this description that the invention is not limited to the illustrated examples but that the invention also includes a variety of modifications and embodiments thereto. Therefore the present description should be seen as illustrative and not limiting. While the invention is susceptible of various modifications and alternative constructions, it should be understood that there is no intention to limit the invention to the specific forms disclosed. On the contrary, the invention is to cover all modifications, alternative constructions, and equivalents falling within the essence and scope of the invention as defined in the claims. To more particularly describe the features of the present invention, please refer to the attached in conjunction with the discussion below.
Most electrospray ionization devices used in mass spectrometry utilize hollow emitter structures, comprising internal channels through which an analyte-bearing fluid flows until it emerges at a hollow emitter tip. However, electrospray emitters are known to which fluid is supplied externally. For instance, Vel�squez-Garc�a et al., in a technical paper titled "A planar array of micro-fabricated electrospray emitters for thruster applications (Journal of Microelectromechanical Systems, 15(5), 2006, pp. 1272-1280) describe planar arrays of micro-fabricated electrospray emitters intended for space propulsion applications. As shown in
United States Patent Application Publication 2009/0140137 A1 in the names of Hiraoka et al. teaches an ionization apparatus comprising holding means for holding a probe so as to be capable of reciprocating between a bottom end point at which a tip of the probe contacts a sample and a top end point at which the tip of the probe is spaced away from the sample; an ion guide, arranged such that the tip of the ion guide is positioned in the vicinity of the tip of the probe in the vicinity of the top end point, for introducing sample ions from the tip thereof to a mass spectrometry apparatus; and a high voltage generating apparatus applying a high voltage for electrospray between the probe and the ion guide, at least at a time when the probe is separated from the sample. A portion of the Hiraoka et al. apparatus is illustrated in
As taught by Hiraoka et al., a laser device (not shown) for irradiating the vicinity of the probe tip with laser light (ultraviolet, infrared or visible light) may be provided, such that the vicinity of the probe tip at the origin position or a position somewhat removed from the tip (a spaced-away position beneath the tip) may be irradiated with the laser beam 36. In the case of visible laser light [e.g., a frequency-doubled (532 nm) YAG laser], a surface plasmon is induced on the metal (probe) surface irradiated with the laser beam. The surface plasmon propagates along the probe surface toward the tip and intensifies the electric field strength in the vicinity of the probe tip. Accordingly, desorption ionization of sample molecules by electrospray is intensified. In a case where use is made of infrared laser light, promotion of sample drying and efficiency of ion desorption from a droplet are improved by heating the captured sample portion 32 c.
The latent ion tracks are exposed to a suitable etchant 112 so as to produce an array of etch channels 110 within the substrate 102. Although the etch channels are shown as conical in shape, the etch channels may be made to approach cylindrical shapes by appropriate choice of etchant selectivity (the ratio of the etch rate of the latent track zone to the etch rate of the bulk substrate). One or more patterned masks, such as masks 109 a and 109 b, may be employed, either sequentially or simultaneously, so as to produce differential etch depths. For instance, mask 109 a may be initially employed so as to expose a central portion of the set of latent ion tracks to an etchant for a first length of time so as to produce relatively deep channels. Mask 109 b may be subsequently employed to expose peripheral regions of the set of latent ion tracks to the etchant for a shorter length of time, so as to produce relatively shallow channels in a region surrounding the deeper channels.
After the etch channels are formed at the desired depths, a multi-pillared electrode 114 may be formed by deposition of a conductive material in the etch channels 110 and onto an adjoining face of the substrate, the etch channels and adjoining face acting as a mold for the formation of the multi-pillared electrode 114. For instance, metal may be first sputtered onto the etched substrate so as to produce a continuous thin coating of metal within the etch channels and on the face of the substrate. Subsequently, the thin metal coating may used as an electrode in an electroplating process to as deposit a larger amount of bulk metal within the same regions, thereby forming the multi-pillared electrode 114 comprising a plurality of pillars 116.
The process described above can produce a material that has a large number of pillars per unit area—typically 10-100 million per square centimeter, corresponding to an average inter-pillar spacing in the range of 1-3 μm. The tips of the pillars, from which ions are emitted when the electrode is in use as an electrospray emitter, can have a diameter of less than 1 μm. The density of pillars may controlled by controlling the duration of exposure of the substrate to the accelerated heavy ions. Although the protrusions in this example are described as "pillars", it should be clear that, depending on form factors, semantic preferences and other circumstances, the protrusions of the electrodes described in this document may, in any particular instance, be more aptly described as "columns", "cones", "needles", "rods" or "wires". These are all various types of protrusions or protruding surfaces away from a base or away from a basal surface.
Optionally, all or portions of the exposed side of the multi-pillared electrode may have a coating 115 deposited on it (them), the coating imparting further structural integrity or desirable surface properties to the multi-pillared electrode. For instance, the coating 115 may comprise a hydrophilic material which may have the function of increasing the tendency of an aqueous analyte-bearing liquid to spread along the surface of the coated multi-pillared electrode. Alternatively, the surface of the multi-pillared electrode 114 may receive a surface treatment, such as roughening of the surface on a nanometer scale, to increase the "wetting" tendencies of analyte-bearing liquids applied to the surface. New types of coatings are discussed by P. Forbes in an article titled "Self-Cleaning Materials" (Scientific American, August 2008, pp. 88-95. For instance, a thin-film coating of titania (TiO2) that has been exposed to ultraviolet light may provide "superhydrophilic" properties to the electrode, enabling an analyte-bearing liquid to spread along the surface as a film along the coated portions of the electrode. Such coating could even be patterned so as to channel the liquid—that is, direct the liquid along pre-determined pathways—on the surface of the electrode. Further, coatings are known whose wettability properties are "switchable"—capable of being controllably and reversibly transformed between (super)hydrophilic and (super)hydrophobic states with the application of certain wavelengths of light. Such coatings applied to all or portions of the multi-pillared electrode 114 may act as valves (for instance, "shut-off" valves) for initiating, stopping or even controlling rate of liquid flow to the pillars of the electrode.
In a second alternative procedure (
The individual pillars of the device resulting from the set of operations illustrated in
An end product of the fabrication steps discussed above is the monolithic or continuous-surface multi-pillared electrode 114. In some embodiments, the multi-pillared electrode may comprises approximately 1000-10,000 emitting pillars or needles per cm2 (inter-pillar spacing of emitting pillars of approximately 100-320 μm) with each emitting pillar having a height of approximately 10 μm to several tens of microns above an inter-pillar base portion of the electrode. Such an electrode could provide the benefits of nanospray ionization into flow regimes characteristic of typical liquid chromatography experiments. For example, in order to be compatible with mass spectrometer ion inlets, such an electrode may have a "footprint" area of about 1 cm2 or less. If an electrode of 1 cm2 footprint area comprises 1000 emitting pillars, each pillar capable of ionizing 100 nanoliters (nl) of solution per minute, then the combined action of all the pillars can ionize 0.1 ml/min of sample, which is within the realm of routine laboratory sample flow rates. Generally, the ionization rate per pillar will be the flow-limiting step. Each pillar will "drain", on average, an amount of liquid equivalent to approximately 1 μm depth per minute, which should be well within the replenishment capabilities of the liquid delivery conduits or channels.
Some embodiments may employ a smaller emitter electrode having a square area of approximately 1 mm2, which may be suitable for interchange with conventional single-capillary electrospray devices. Assuming an inter-pillar spacing of emitting pillars of approximately 31-32 μm, then 1000 emitting pillars can be incorporated onto such an electrode, corresponding to a pillar density of 100,000 per cm2. In this situation, the ability to distribute the liquid evenly among the pillars must be considered. If, once again, the liquid delivery rate is 0.1 ml/min and each pillar ionizes 100 nanoliters (nl) of liquid per minute, then each pillar is required to drain, on average, an amount of liquid equivalent to approximately 100 μm depth per minute. Even though this depth is generally greater than the pillar heights, it still may be possible to achieve such a flow rate with a steady state depth of approximately 1.5-2.0 μm that will not flood the electrode tips, provided that the fluid surge is prevented and that even fluid flow may be maintained in the inter-pillar regions of the electrode. A superhydrophobic coating or even perforations in the inter-pillar base portions of the electrode (to enable liquid delivery through the electrode from a substrate or reservoir on the opposite side) may be advantageously employed in this situation.
The extractor electrode 130 (also referred to as a counter electrode) comprises an aperture 131 through which charged particles emitted from a sample pass under the influence of an electrical potential applied between the multi-pillared emitter electrode 114 and the extractor electrode 130. The extractor electrode may comprise a portion of a mass spectrometer and, as such, the aperture 131 may comprise an ion inlet aperture of a mass spectrometer. The aperture 131 may be subdivided into a plurality of sub-apertures 132 separated by partitions or other structural elements. The apparatus 101 may, optionally, further comprise a cover plate 120 that is disposed substantially perpendicular to the longitudinal axes of the pillars 116 and that is maintained at a distance from the base portions or inter-pillar portions 113 of the multi-pillared emitter electrode 114 by means of one or more spacers 122. The size of the resulting gap between the base or interpillar portions 113 and the cover plate 120 could be controlled to regulate the flow of liquid and prevent it from spilling out. This gap can also serve as a buffer reservoir to guard against overfilling of the apparatus from an externally supplied liquid pumped into the apparatus at a rate that does not match the rate of wicking of liquid along the pillar surfaces.
One or more fluid inlet conduits 124 such as capillary tubes may pass through the one or more spacers 122 so as to introduce analyte-bearing sample liquids into the gap or gaps between the base or inter-pillar portions 113 of the multi-pillared emitter electrode 114 and the cover plate 120. The fluid inlet conduit or conduits 124 may serve, for instance, to couple the apparatus to a liquid chromatograph or a syringe pump so that eluent would flow into the gap and between the pillars 116 so as to be subsequently wicked towards the pillar tips. The emitter electrode 114 may be formed into a region of relatively short pillars 111 (for instance, see the upper right drawing of
Generation of an electric field in the vicinity of the emitter electrode 114 by application of a voltage difference between the multi-pillared emitter electrode and the extractor electrode 130 produced a concentration of electric field lines at each pillar tip. With sufficient electric field strength, the analyte-bearing liquid 126 deforms into a Taylor cone 117 at each respective pillar tip and emits a charged stream 128, comprising a jet, a spray of charged liquid droplets and, ultimately, a cloud of free ions. The emitter plate is set to be the anode if positively charged ions are to be emitted and is set to be the cathode if negatively charged ions are to be emitted. The liberated ions are then electrostatically directed into an ion inlet orifice of a mass spectrometer for analysis. The extractor electrode may, in fact, comprise an ion inlet orifice plate of the mass spectrometer. In order to minimize space charge effects, the pillar tips may be located at a distance from a mass spectrometer ion inlet port such that the ion flow has been accelerated towards the ion inlet port up to a velocity greater than a certain threshold velocity—for instance, greater than about 10-50 m/s.
Still referring to
In operation, the nano-electrospray apparatus 400 is utilized to introduce electrosprayed ions into the ion inlet orifice of a mass spectrometer similar to the situation illustrated in
The nano-electrospray multi-emitter array 302 shown in
The discussion included in this application is intended to serve as a basic description. Although the present invention has been described in accordance with the various embodiments shown and described, one of ordinary skill in the art will readily recognize that there could be variations to the embodiments and those variations would be within the spirit and scope of the present invention. The reader should be aware that the specific discussion may not explicitly describe all embodiments possible; many alternatives are implicit. Accordingly, many modifications may be made by one of ordinary skill in the art without departing from the spirit, scope and essence of the invention. Neither the description nor the terminology is intended to limit the scope of the invention. Any publications, patents or patent application publications mentioned in this specification are explicitly incorporated by reference in their respective entirety.
|Cited Patent
|Filing date
|Publication date
|Jun 12, 1990
|Dec 22, 1992
|Apricot S.A.
|Forming charges in liquid and generation of charged clusters
|Jan 4, 1994
|Mar 14, 1995
|American Technologies, Inc.
|Forming charges in a fluid and generation of a charged beam
|Sep 17, 1998
|Jun 12, 2001
|Kionix, Inc.
|Integrated monolithic microfabricated electrospray and liquid chromatography system and method
|Oct 31, 2000
|May 13, 2003
|James E. Moon
|Integrated monolithic microfabricated electrospray and liquid chromatography system and method
|Dec 20, 1999
|Oct 14, 2003
|Advion Biosciences, Inc.
|Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
|May 24, 2002
|Jun 1, 2004
|New Objective, Inc.
|Method and apparatus for feedback controlled electrospray
|Sep 7, 2007
|Dec 20, 2011
|Michigan Technological University
|Self-regenerating nanotips for low-power electric propulsion (EP) cathodes
|Jan 18, 2001
|Jan 3, 2002
|Corso Thomas N.
|Separation media, multiple electrospray nozzle system and method
|Oct 5, 2001
|Oct 31, 2002
|Moon James E.
|Integrated monolithic microfabricated electrospray and liquid chromatography system and method
|May 23, 2002
|Nov 28, 2002
|Valaskovic Gary A.
|Method and apparatus for multiple electrospray sample introduction
|May 18, 2001
|Dec 12, 2002
|Smith Richard D.
|Ionization source utilizing a multi-capillary inlet and method of operation
|Jun 17, 2002
|Jun 19, 2003
|Staats Sau Lan Tang
|Microfluidic array devices and methods of manufacture and uses thereof
|Jan 23, 2003
|Jul 31, 2003
|Schultz Gary A.
|Multiple electrospray device, systems and methods
|Feb 25, 2002
|Aug 28, 2003
|Glish Gary L.
|Electrospray ionization device
|Mar 5, 2002
|Sep 11, 2003
|Smith Richard D.
|Method and apparatus for multispray emitter for mass spectrometry
|Apr 1, 2003
|Oct 30, 2003
|Corso Thomas N.
|Separation media, multiple electrospray nozzle system and method
|Mar 21, 2003
|Nov 20, 2003
|Jun Kameoka
|Electrospray emitter for microfluidic channel
|Mar 12, 2004
|Sep 9, 2004
|New Objective, Inc.
|Method for feedback controlled electrospray
|Nov 5, 2003
|Nov 18, 2004
|Park Melvin A.
|Means and method for multiplexing sprays in an electrospray ionization source
|Aug 31, 2004
|Mar 10, 2005
|Fedorov Andrei G.
|Electrospray systems and methods
|May 13, 2004
|Nov 17, 2005
|Eksigent Technologies, Llc
|Nov 1, 2005
|May 18, 2006
|Staats Sau Lan T
|Microfluidic array devices and methods of manufacture thereof
|Nov 7, 2003
|Jun 1, 2006
|Diagnoswiss S.A.
|Apparatus for Dispensing a Sample in Electrospray Mass Spectrometers
|Jan 31, 2006
|Aug 24, 2006
|Bruker Daltonik Gmbh
|Apparatus and method for the transport of ions into a vacuum
|Oct 5, 2005
|Aug 31, 2006
|Devoe Donald L
|Methods and apparatus for porous membrane electrospray and multiplexed coupling of microfluidic systems with mass spectrometry
|Apr 25, 2006
|Sep 21, 2006
|Walter Schmidt
|Microfluidic device with various surface properties fabricated in multilayer body by plasma etching
|Mar 15, 2005
|Sep 21, 2006
|Goodley Paul C
|Nanospray ion source with multiple spray emitters
|Sep 8, 2006
|Aug 9, 2007
|Eksigent Technologies, Llc
|Variable flow rate system for column chromatography
|Aug 27, 2008
|Mar 5, 2009
|United States Of America As Represented By The Secretary Of The Army
|Process of forming an intergrated multiplexed electrospray atomizer
|Oct 15, 2008
|Apr 16, 2009
|Phoenix S&T, Inc.
|Integrated microfluidic nozzle device for chromatographic sample preparation for mass spectrometry applications
|Nov 2, 2007
|May 7, 2009
|Licentia Oy
|Micropillar array electrospray chip
|Oct 28, 2008
|Jun 4, 2009
|Kenzo Hiraoka
|Ionization method and apparatus using electrospray
|Mar 11, 2008
|Sep 17, 2009
|Battelle Memorial Institute
|Radial arrays of nano-electrospray ionization emitters and methods of forming electrosprays
|Feb 5, 2007
|Dec 3, 2009
|Waters Investments Limited
|Methods and apparatus for generating solvent gradients in liquid chromatography
|Feb 8, 2010
|Aug 11, 2011
|Agilent Technologies, Inc.
|Flow Distribution Mixer
|Aug 18, 2010
|Feb 23, 2012
|Wouters Eloy R
|Ion Transfer Tube Having Single or Multiple Elongate Bore Segments and Mass Spectrometer System
|Mar 20, 2009
|Sep 24, 2009
|Queen's University At Kingston
|Multi-channel electrospray emitter
|Blaise Laurent Patrick Gassend, "A Fully Microfabricated Two-Dimensional Electrospray Array with Applications to Space Propulsion," PhD Dissertation, MIT 2007, pp. 1-104.
|Chen et al., "Abstract," J. Phys. Chem. B, 2008, 112 (35), pp. 11164-11170.
|Chen et al., "Characteristics of Probe Electrospray Generated from a Solid Needle," J. Phys. Chem. B 2008, 112, pp. 11164-11170.
|Ficarro et al., "Improved Electrospray Ionization Efficiency Compensates for Diminished Chromatographic Resolution and Enables Proteomics Analysis of Tyrosine Signaling in Embryonic Stem Cells," Anal. Chem. 2009, 81, pp. 3440-3447.
|Gassend et al., "A Fully-Integrated Microfabricated Externally-Wetted Electrospray Thruster," 30th International Electric Propulsion Conference, Florence, Italy, Sep. 17-20, 2007, pp. 1-11.
|Gassend et al., "A Microfabricated Planar Electrospray Array Ionic Liquid Ion Source With Integrated Extractor," Journal of Microelectromechanical Systems, vol. 18, No. 3 (2009), pp. 679-694.
|Ibrahim et al., "Improving Mass Spectrometer Sensitivity Using a High-Pressure Electrodynamic Ion Funnel Interface," J. Am. Soc. Mass Spectrom. 2006, 17, pp. 1299-1305.
|Kelly et al., "Array of Chemically Etched Fused-Silica Emitters for Improving the Sensitivity and Quantitation of Electrospray Ionization Mass Spectrometry," Anal. Chem. 2007, 79, pp. 4192-4198.
|Kelly et al., "Elastomeric Microchip Electrospray Emitter for Stable Cone-Jet Mode Operation in the Nanoflow Regime," Anal. Chem. 2008, 80, pp. 3824-3831.
|Kelly et al., "Nanoelectrospray Emitter Arrays Providing Interemitter Electric Field Uniformity," Anal. Chem. 2008, 80, pp. 5660-5665.
|Kingham et al., "Shape of a Liquid Metal Ion Source," Appl. Phys. A 34 (1984), pp. 123-132.
|Krpoun et al., "Integrated out-of-plane Nanoelectrospray Thruster Arrays for Spacecraft Propulsion," J. Micromech. Microeng. 19 (2009) 045019, pp. 1-10.
|Manohara et al., "Arrays of Bundles of Carbon Nanotubes as Field Emitters," http://www.techbriefs.com/component/content/article/1206, pp. 1-3.
|Oleinikov et al., "The Study of the Desorption/Ionization from the Replicas of Etched Ion Tracks," Radiation Measurements 43 (2008) , pp. S635-S638.
|Patel et al., "Complex Multifunctional Polymer / Carbon-Nanotube Composites," NASA Tech Briefs (2009), http://www.techbriefs.com/component/content/article/3540.
|Peter Forbes, "Self-Cleaning Materials-The lotus plant's magnificent ability to repel dirt has inspired a range of self-cleaning and antibacterial technologies that may also help control microfluidic "lab-on-a-chip" devices.," Scientific American (2008), pp. 88-95.
|Peter Forbes, "Self-Cleaning Materials—The lotus plant's magnificent ability to repel dirt has inspired a range of self-cleaning and antibacterial technologies that may also help control microfluidic "lab-on-a-chip" devices.," Scientific American (2008), pp. 88-95.
|Schultz et al., "A Fully Integrated Monolithic Microchip Electrospray Device for Mass Spectrometry," Anal. Chem. 2000, 72, pp. 4058-4063.
|Sen et al., "Simulation and Parametric Study of a Novel Multi-Spray Emitter for ESI-MS Applications," Microfluid Nanofluid (2007) 3:283-298.
|Shikida et al., "Fabrication of a Hollow Needle Structure by Dicing, Wet Etching and Metal Deposition," J. Micromech. Microeng. 16 (2006) , pp. 2230-2239.
|Shikida et al., "Fabrication of Densely Arrayed Micro-Needles with Flow Channels by Mechanical Dicing and Anisotropic Wet Etching," J. Micromech. Microeng. 16 (2006) , pp. 1740-1747.
|Shikida et al., "Non-Photolithographic Pattern Transfer for Fabricating Arrayed Three-Dimensional Microstructures by Chemical Anisotropic Etching," Sensors and Actuators A 116 (2004) , pp. 264-271.
|Shikida et al., "Non-Photolithographic Pattern Transfer for Fabricating Pen-Shaped Microneedle Structures," J. Micromech. Microeng. 14 (2004) , pp. 1462-1467.
|Tang et al., "Generation of Multiple Electrosprays Using Microfabricated Emitter Arrays for Improved Mass Spectrometric Sensitivity," Anal. Chem. 2001, 73, pp. 1658-1663.
|Toda et al., "Fabrication of Gate-Electrode Integrated Carbon-Nanotube Bundle Field Emitters," NASA's Jet Propulsion Laboratory (2008), http://www.greentechbriefs.org/component/content/2710?task=view.
|Toda et al., "Improved Photoresist Coating for Making CNT Field Emitters," NASA Tech Briefs (2009), pp. 38, 40.
|Toda et al., "Improved Photoresist Coating for Making CNT Field Emitters," NASA's Jet Propulsion Laboratory (2009), http://www.techbriefs.com/component/content/article/3532.
|Velasquez-Garcia et al., "A Micro-Fabricated Linear Array of Electrospray Emitters for Thruster Applications," Journal of Microelectromechanical Systems, vol. 15, No. 5 (2006), pp. 1260-1271.
|Velasquez-Garcia et al., "A Planar Array of Micro-Fabricated Electrospray Emitters for Thruster Applications," Journal of Microelectromechanical Systems, vol. 15, No. 5 (2006), pp. 1272-1280.
|Wilm et al., "Analytical Properties of the Nanoelectrospray Ion Source," Anal. Chem. 1996, 68, pp. 1-8.
|Wouters et al., "Apparatus and Methods for Pneumatically-Assisted Electrospray Emitter Array," U.S. Appl. No. 12/642,573, filed Dec. 18, 2009, pp. 1-41.
|Citing Patent
|Filing date
|Publication date
|May 30, 2012
|Jun 11, 2013
|Thermo Finnigan Llc
|Multi-needle multi-parallel nanospray ionization source for mass spectrometry
|Feb 28, 2012
|Jul 9, 2013
|Tiza Lab, L.L.C.
|Microplasma ion source for focused ion beam applications
|Jun 18, 2012
|Sep 24, 2013
|Aqua Treatment Services, Inc.
|Ultraviolet reactor
|May 22, 2012
|Mar 18, 2014
|Tiza Lab, L.L.C.
|Microplasma ion source for focused ion beam applications
|Mar 11, 2013
|Mar 10, 2015
|1St Detect Corporation
|Systems and methods for calibrating mass spectrometers
|Apr 30, 2014
|Jun 23, 2015
|Ut-Battelle, Llc
|AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe
|Jan 22, 2015
|Mar 29, 2016
|1St Detect Corporation
|Systems and methods for calibrating mass spectrometers
|Jun 14, 2013
|Jun 7, 2016
|Massachusetts Institute Of Technology
|Electrically-driven fluid flow and related systems and methods, including electrospinning and electrospraying systems and methods
|Dec 18, 2015
|Jun 7, 2016
|Massachusetts Institute Of Technology
|Method and apparatus for a porous electrospray emitter
|Jul 21, 2014
|Oct 25, 2016
|Massachusetts Institute Of Technology
|Method and apparatus for a porous electrospray emitter
|May 30, 2012
|Sep 20, 2012
|Makarov Alexander A
|Multi-Needle Multi-Parallel Nanospray Ionization Source for Mass Spectrometry
|Jun 14, 2013
|Dec 4, 2014
|Massachusetts Institute Of Technology
|Electrospraying systems and associated methods
|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification
|Mar 15, 2010
Owner name: THERMO FINNIGAN LLC, CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MAKAROV, ALEXANDER A.;WOUTERS, ELOY R.;SIGNING DATES FROM 20100129 TO 20100201;REEL/FRAME:024083/0278
|Dec 9, 2015
|Fee payment
Year of fee payment: 4


text:
Re: look up for MCKENZIE in hobart please
In reply to:
Re: look up for MCKENZIE in hobart please
jenny ross 12/11/08
thanks steve, l think it is an error as william mckenzies death cert. has his mother as elizabeth mclerie and his father is william.yes l know that tas. certs are expensive, so that would be my last resort. can you tell me if they provide much more information on them than what we already have?regards jenny


text:
Alchemy Gothic - Claustramoris Pendant Necklace
Product Code: P647
Alchemy Gothic - Claustramoris Pendant Necklace
This Alchemy pendant is a delaying key, named from the Latin and worn to prove ones independence, self-control and emotional autonomy: set with Swarovski crystal.
All pendants are cast and hand-made in fine English pewter, many have additional high quality crystals and components, hand plated or other two-tone finish and come complete with nickel-free chain or other necklace of appropriate length.
Please Note:
Please allow up to 7-14 days for this item to arrive. If you need this item for a specific date please ensure you let us know by email here: firstname.lastname@example.com
Customer Reviews
This product hasn't been reviewed yet.


text:
The year is finished and thanks to alot of friends and family I ended up finishing 15 in the world standings. This was good enough for me to qualify back to the 2008 Calgary Stampede.
The last month was a trying month, for myself, family and friends. I sat in the last open spot to return to calgary with 4 shows left to go . I had a average drumheller and than things started to go good in strathmore with some really good results and jumped back up in the standings. I created a little cushion between myself and the guy in 18th hole.
Mike Vigen , Troy flad , Grant Profit and myself were all fighting (or racing) to qualify for three spots. Mike was the guy on the outside hole but was on fire and gaining ground rapidly. Dawson Creek started good with me having a chance to make the dash only 1 second behind the fourth placed guy going into night four. We had the barrel 4 and had a good turn but the competition was strong and held me outside . I ended up tenth in the show and headed home right after the races. I got home at 4 in the morning and went in for a nap b/c we had to head to Red Deer by noon. The crew (katie) who slept all the way home, had the feed loaded and ready to go by 10 am and i woke up and decided to turn a horse out for the rest of the year. He was full of P&V and when i went to put him out to pasture he kicked me. Off to the hospital in Devon than to the University hospital in a Ambulance (first ride ever in there and hopefuly the last) The Day went by fast with lots of things happening and tests . After all was said and done the diagnosis was a smashed and lacerated kidney. I ended up spending 5 days there and missed the entire Red Deer show.
Shane Cartier drove my horses and I had lots of friends help out . My sponsors were great and very accomadating to my barn staff and family. I think this is why I love this sport so much is because i had numerous calls and support from everyone and i thank them all. Shane ended up doing a good job and we ran penalty free and my team qualified back to the Calgary Stampede.
While i was at the Hospital I am not sure if i was ever left alone . My family was GREAT and they all spent more than ther due time in helping me at the hospital, along with organizing things in Red Deer. Thanks to all the people that called and thanks to those who visited.
I am on the mend and I have weekly check ups booked for the next two months. Than the doctor will determine if I need surgery or not, from the early diagnosis things are heading in the right direction .
I stopped and talked to Tyler Helmig today and things seem to be slowly getting better with him to. I am pretty sure i will beat him in the race to recover though he has surgery left on his hip.
The horses got turned out in the pasture and they just love to run, i wish i had there energy .


text:
Cherie's updates at the intersection of music, technology, creativity, business, people, travel and potatoes.
A weekly newsletter that gives you 6 brief personal recommendations of cool stuff.
We work and play with machines, pushing their limits and exploring boundaries.
By Angel Trinidad // I am an editor, writer and creative strategist based in Amsterdam, curating the world's most sparkling trends. As Keen On Walls, I present the most inspiring interiors, design and spaces around the world. Angel Magazine is a personal newsletter, a diary of things that inspire me, and make my heart beat faster. // www.keenonwalls.com | www.angeltrinidad.me
I'm passionate about the written word, coaching, and supporting writers. Every week, I gather up the best and most interesting bits on writing and creativity and deliver it to your email in tasty little bite-size newsletters. PS: Remember, there is no wrong or right, just write!
Updates on how artificial intelligence and robotics are affecting jobs
Deep Learning Weekly helps you keep up with the breakneck pace of new developments in the field by bring you all that's new and exciting from academia to the grubby depth of industry right to your inbox. Check out our blog at www.deeplearningweekly.com.
Applied Artificial Intelligence - Local AI news - Events - Global AI Community with more than 20 chapters.
Your weekly newsletter on the hottest things in Artificial Intelligence carefully curated by Avinash Hindupur!
An analytical digest of artificial intelligence and machine learning news from the technology industry, research lab and venture capital market.
A brief weekly roundup of the hottest things in user experience, product design & startups. Curated by @arunpattnaik.
This Week in #Health #Tech #Design by @CalamineDesign - Daylighting the most intriguing news, tools and resources for startups and product designers in healthcare.
TGIC is a weekly curation of the best content at the intersection of Architecture, Design and Technology curated with ❤ by Vignesh Kaushik.
The Agenda is a collection of gadgets, gear, and more, curated by me – Andrew Meyers (@andrewmeyers). This email contains a digest of what I published in the last week, plus some extras I think you'll like. Check out the entire site at: https://theagenda.cc.
Refining a smooth operating motion: ideas, business, technology, sports, great reads
My digest is a collection of inspirational and instructional resources I find interesting and wish to share, including my latest content. To save you time, I pen a quick preview & highlight the key parts to check out.
This is a semi-regular newsletter about what I find new and interesting in virtual reality.
Your weekly roundup of VR and 360° Video. Explore the new realities of immersive storytelling.
A bi-weekly update with on online growth, digital marketing and conversion optimisation. I'm building 4 online companies with a remote team while travelling.
Your weekly dose of growth inspiration. The best growth reads we found on the web this week. Disruptive innovations, growth-hacks, startups & scale-ups. Short and simple. Carefully curated by RevelX - http://revelx.co/
This is a weekly list of project manager job openings at top tech and startup companies in New York. Use it to make finding your next project management job at a top New York tech or startup company easier and faster.
A weekly newsletter with a handpicked selection of the best sailing articles on the web to help you become a better sailor, and to take care of your boat.
A weekly collection of articles, news, interests and curiosities lovingly curated for you
Weekly stories from the startup trenches and my way to help others take their idea from zero to one, and beyond. I'm a serial entrepreneur, Advisor @inkl, Ambassador @inspRAREBIRDS and AProf @UNSWAGSM. I blog at philhsc.com
I read A LOT so you only read the best. Get a handpicked roundup of the best links every Friday. Curated by Lauren Holliday for the very affordable price of free. http://hackthejobhunt.com
A weekly newsletter covering the exponential change at the intersection of technology and society through a product lens. Curated by @ppetrovski and published every Friday.
Curated content about Product Management and Marketing. From idea validation to achieving product/market fit.
A weekly batch of resources, thoughts, and motivation from a friendly digital agency owner delivered every Monday at 6am ET.
3 long-reads about startups and entrepreneurship in your inbox every Saturday morning. Plus a free update on what's happening at NEXT. NEXT Amsterdam is a startup studio from Amsterdam.
TGIC is a weekly curation of the best content at the intersection of Architecture, Design and Technology curated with ❤ by Vignesh Kaushik.
Technology, Startups & the Future. I'm lucky when it comes to finding amazing content written by others and want to share that luck with you. Find me at http://twitter.com/bryceadams 💖
The CFO Brain newsletter is a weekly hand-curated (no 🤖 involved) compilation of the best technology, finance and business articles for CFOs, Treasurers and Finance Teams.
The most interesting things I've seen in blockchain, tech, and our decentralizing world as seen from the world's border with China.
Since catching up with all the dev news is hard, we're doing it for you. Swift Weekly helps you to stay on top of things and provides you with everything you need to know about Swift. Learn from code samples, screencasts and articles from experienced developers. Use code snippets for your own projects. Whether you're getting started or just want to deepen your knowledge, we've got you covered.


text:
About Say Not "What If"by Andrew Friedman
A dying man craves the time he has lost. Written as a long rhyming poem, Say Not "What If" recounts his journey and the consequences of the choices he makes in a desperate desire to stay alive. Exceptionally easy to read and understand, many readers have praised the power and thought provoking nature of this unique story. What would you do for more time?
Buy the book, and follow the author on social media:
Buy the Book On Amazon.


text:
出版时间:2004-8作者:Parker, Jan; Parker, Tony书名:The Hippo-not-amus我不想作河马
Kindergarten-Grade 2–Portly is trying to find his true self. He was born a hippopotamus, but is sick of wading in water and eating boring, old grass. Searching for new possibilities, he sets off on a quest where he encounters a herd of rhinoceros, a bat, an elephant, and a giraffe, and transforms himself into a hippo-gir-ele-bat-onoceros. Each new identity has comical, albeit unsuccessful consequences. His adventures make him long for the cool waters of home and grass. Portly and his parents are glad to be reunited, but when he sees a monkey swinging from tree to tree, he knows his explorations must continue. The artist uses bright, sunny colors, portraying this jungle fantasy through large, eye-catching paintings. Portly's multifaceted personality is well illustrated. While the theme is far from new, children will enjoy the humorous tale and will identify with Portly's desire to try out new personas. A smooth flowing, witty text gives this tale good storytime potential.–Be Astengo, Alachua County Library, Gainesville, FL Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved. --This text refers to the Hardcover edition.
The Hippo-not-amus我不想作河马下载
The Hippo-not-amus我不想作河马下载


text:
Kent Reliance Building Society may be tiny, but its big new idea is generating huge interest from borrowers and mortgage advisers. The UK's first inter-generational mortgage is a home loan that can be passed on from parents to children.
The initiative is aimed at both younger borrowers keen to get a foot on the increasingly unaffordable housing ladder, and older borrowers who want to maximise their disposable income. And there's even the prospect of a smaller inheritance tax bill for some families.
There are two parts to the deal. The first is that Kent Reliance's mortgage is an interest-only loan. Borrowers make no capital repayments at all - each month they just service the mortgage interest - cutting the cost of repayments.
Second, while most mortgages are set up on a 25 or 30-year term - by the end of which all the capital borrowed must be repaid - Kent Reliance will allow borrowers to take out loans over a much longer period. It has no set maximum, so the term could be 40 or even 60 years and if borrowers die before the loan is repaid, the whole deal can be passed on to their children.
Although Kent Reliance will review these mortgages every five years, borrowers will be able to hold on to the loans well into retirement as long as they can prove they have the ability to keep on meeting the monthly repayments.
Such loans are already commonplace in Japan, where inter-generational mortgages enabled buyers facing runaway house prices to borrow over periods of up to 100 years. Loans were passed on to children and even grandchildren if they had not been repaid on death.
"This is about giving people options - not telling them how to live their lives, not telling them that they can only have a 25-year mortgage which has to be paid off at the end of the term," says Mike Lazenby, the chief executive of Kent Reliance.
"It's worked in Switzerland and Japan, but in this country we do tend to think in straight lines - I think a bit of innovation should be encouraged."
Lazenby thinks the deal will appeal to several types of borrowers. Younger first-time borrowers would find monthly mortgage repayments more affordable, he says, while older borrowers may be keen to make the most of their income, and to keep repayments down to the minimum level possible.
The inheritance tax benefit is also attractive, the society believes. If you're left a house worth more than the annual threshold - £285,000 this year - there is 40 per cent tax to pay on its value. But the outstanding mortgage on the property comes off its value pound for pound, reducing or eliminating the tax bill.
Even without the tax benefit, there are savings to make. The monthly repayments on a £200,000 25-year Kent Reliance capital repayment mortgage - fixed at 5.15 per cent for five years - would be around £1,200, for example. On an interest-only basis, however, borrowers would pay around £350 a month less.
Even so, mortgage experts are highly sceptical. James Cotton, of independent mortgage broker London & Country, says: "If you have an interest-only mortgage for 60 years, the total repayments that you'll make to the mortgage company are likely to be much more than your children would have paid in inheritance tax."
Melanie Bien, of Savills Private Finance, another adviser, says that while a typical 25-year £200,000 repayment mortgage would cost around £350,000 (and leave you owning the entire property), borrowers would pay £400,000 on an interest-only mortgage over 40 years, and still own none of the equity.
Mike Warburton, of accountants Grant Thornton, adds that the benefits in terms of inheritance tax mitigation have also been overplayed. Although the IHT liability will indeed be smaller on a property with a mortgage, homeowners can achieve the same outcome by using equity-release products to unlock capital from their home.
Finally, Ray Boulger of mortgage broker John Charcol, says the burden of paying a mortgage in retirement should not be taken lightly. "If someone has got to the stage where they are taking out an interest-only mortgage because it is all they can afford, they should remember that they're even less likely to be able to afford it in retirement," he says.
As for the international success of inter-generational mortgages, there are doubts here too. In Japan, after thousands of homeowners had signed up to 100-year mortgages, the market eventually collapsed, leaving many borrowers sitting on loans which were much greater than the value of their property.
Keith Tondeur, the chief executive of Credit Action, the debt charity, says: "With debt in the UK causing problems for a record number of people and the 'buy now, worry about it later' culture in the ascendancy, people need to be aware that interest-only mortgages are high risk, particularly in a time of rising interest rates."
Tondeur also points out that lenders have most to gain. "Affordable housing is a very pressing need in the UK currently as many younger people struggle to afford property," he says. "Encouraging people to take on expensive debt may be popular with institutions such as Kent Reliance, which stand to profit healthily, [but] it is not the best solution."
Looking for credit card or current account deals? Search hereReuse content


text:
Ratings & Reviews
The views expressed below are the opinion of Holland & Barrett customers. Holland & Barrett does not endorse these views, nor should they be regarded as health claims or medical advice. Find out more
Holland & Barrett Coupled Cashews & Raisins is rated out of 5 by 19.
Rated 5 out of 5 by Tineille from I enjoyed this project alot especially when I am in the mood for a healthy tasty snack.
Date published: 2017-03-02
Rated 3 out of 5 by Britt from Not bad Too many raisins, not enough cashews. Let's say that the cashews drowned in the raisins ....
Date published: 2017-02-25
Rated 5 out of 5 by JosieB from Tasty product + excellent service. We both love this product, such a healthy snack. Much better than eating cake or sweets. Usual excellent on-line ordering & delivery service from H & B. Items arrived securely packaged and on time as promised within delivery period. We always keep a bowl (covered) of these nuts & raisins on the worktop for a quick snack. They are quite filling so you don't gorge on them but they are extremely more-ish so be careful! Though may appear expensive for a 1kg bag it does work out cheaper than buying in only small quantities from the supermarkets. Highly, highly recommended!
Date published: 2016-10-03
Rated 5 out of 5 by RMopus from Great free gift! Delicious and healthy and a bigger bag than expected. Thank you for this gift!
Date published: 2016-08-26
Rated 4 out of 5 by Lionsista from balanced taste what i liked the most was the analogy of the quantities of cashews and raisins! really satisfying taste
Date published: 2016-06-02
Rated 4 out of 5 by Jas12 from Nutritious Great for portioning up into individual bags to take to work for a healthy tasty snack
Date published: 2016-05-28
Rated 5 out of 5 by ChloeAJ from Lovely combination A combination of cashews and raisins providing a creamy taste. Great for when you have a sweet craving but don't want to reach for the chocolate.
Date published: 2016-05-17
Rated 5 out of 5 by Chipstick from My mum loves these. Says they're the best she has tasted
Date published: 2016-05-16


text:
The Host
Brody Stevens is a comedy legend. With a long standing presence in Los Angeles, CA, Brody is a former baseball player and a complete original. Brody is well respected amongst comedians, has been performing for 20+ years and is a cultivator of positive energy.
Take a journey on Brody's history playing baseball.
Show Notes
No show notes for this episode.


text:
Light star red, height 95 cm
Item number: 650.106.01
High-quality light star for Christmas lighting in indoor areas, such as hotels, restaurants or shop windows. Warm-white opal bulbs, that distribute the light ... › More
- Price plus Shipping costs
- 1 piece £269.10 VAT excl. £320.23 VAT incl.
Item x added
Overview of your shopping basket


text:
Posted on 07 January 2016
I was recently asked by Kent's leading newspaper, the Kent Messenger, to make a couple of business predictions for 2016.
My immediate response was Wow! Are you kidding? As if I actually possessed any believable wisdom to impart. With the still unpredictable global economy anyone making predictions really is looking into a massive crystal ball – probably best to ask Major Tim on the Space Station!
Anyway here goes….
1. The refugee crisis. Not exactly a prediction, but a real concern – until conflict is ended, I see no answer. The human tragedy is immeasurable. I see this becoming worse in 2016 with no obvious solution in sight. This is Europe's biggest challenge in 2016 and beyond. Economically the recent terrorist atrocities in Paris and the continuing threat could have significant impact on investment plans – the Euro could be in for a difficult ride and the UK's position within Europe will continue to create uncertainty.
2. The Life Science Sector and a very positive note. Massive tax inversion deals amongst the US global players who will continue to relocate their legal domicile to a lower tax nation. This may have some impact on Kent. Pfizer and Mylan have facilities in the county and both have been active in acquisitions – it's possible we could see increased research activity. If you couple this to the very real support KENT County Council is giving the county's growing life science sector this is definitely a case of watch this space. There is massive potential for our county in this vibrant sector and I see it set for more growth.


text:
Body Armor
12,439pages onAdd New Page
this wiki
this wiki
Body Armor (noun)
- 1. A compadre who is beyond accountability, but not blame.
- 2. The guy in the group who stands as look out and decoy.
See Also: Czar.
Body Armor was The Wørd on the April 12, 2007 edition of "The Colbert Report".