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Safety and immunogenicity of H1/IC31 ®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm 3 : a phase II, multi-centre, double-blind, randomized, placebo-controlled trial Dr. Klaus Reither Swiss Tropical and Public Health Institute AIDS 2014 - Melbourne - 21.07.2014 On behalf of the Aurum102/THYB05 team
Background Tuberculosis: 8.6 million new active TB cases and 1.3 million TB deaths in 2012 (WHO). Urgent need to develop safe and effective TB vaccines to accelerate progress towards TB elimination. Essential to evaluate the safety and immuno- genicity of TB vaccines in HIV-infected persons. Abu Raddad et al, PNAS 2009
Background The H1/IC31 vaccine: recombinant fusion protein Ag85B-ESAT-6 TB vaccine [Hybrid (H1)], adjuvanted with IC31 ® H1/IC31 trials Phase Ia n=36 Phase Ib n=20 Phase Ic n=39 Phase IIa n=240 First trial in HIV-infected individuals Phase IIa n=48
Background Primary objective To evaluate the H1/IC31 TB vaccine in HIV- infected adults for: Safety Induction of cellular and humoral immunity Secondary objective To describe the effect of the H1/IC31 TB vaccine in HIV-infected adults on: CD4+ lymphocyte counts HIV viral loads
Trial sites Ifakara Health Institute: Bagamoyo, TZ Aurum Institute: Tembisa, SA
Trial design Inclusion criteria (summary) Healthy (no evidence of active TB) 18 - 55 years of age HIV infection CD4 > 350/mm 3 Naïve to antiretroviral therapy Women of child bearing potential must not be pregnant and agree to avoid pregnancy No medical history on conditions that compromise the safety evaluation Randomisation H1/IC31 vaccine or placebo was randomly allocated in a 5:1 ratio. Blinding The investigators, study monitors and participants were blinded. The study pharmacists prepared the investigational product. Syringes were masked in order to conceal a slight difference in the appearance of the H1/IC31 and placebo.
Primary immunogenicity endpoint Trial design Study day SCREEN031454565970182 Visit number 1 2345678910 Vaccination Safety Solicited local/systemic AEs XXX XXX Unsolicited AEsXXXXXXXXX QuantiFERONX X Haematology, Serum chemistryX XX XX UrinalysisXXXXXXXXX CD4+ count, HIV-1 viral loadXX X XXXX Immunogenicity WBA ICS X X X XX Schedule of events (summary)
Excluded (n=119) - Screening failure (n=109) - Withdrawn consent (n=1) - Sleep apnoea, persistent shortness of breath (n=1) - Enrolment closed (n=8) Randomised (n=48) H1/IC31 arm (n=40) Received 1 st vaccination (n=40) Placebo arm (n=8) Received 1 st vaccination (n=8) Received 2nd vaccination (n=39) Did not receive 2nd vaccination (n=1), because of pregnancy Received 2nd vaccination (n=8) Lost to follow-up (2nd vaccination and end of study) (n=1) Lost to follow-up (2nd vaccination and end of study) (n=0) Safety analysis (n=8) Screened (n=167) Immunogenicity analysis (n=4) Immunogenicity analysis (n=20) Consort diagram Safety analysis (n=40) Samples from Tembisa Site did not meet internal quality control standards
Variable Placebo (n=8)H1/IC31 (n=40) AgeMean (SD)34 (11.0)35.6 (8.0) GenderFemale n (%)6 (75.0)21 (52.5) Ethnic groupBlack n (%)8 (100)40 (100) Body Mass IndexMean (SD)23.5 (4.2)26.4 (7.4) BCG vaccination (self-report) Yes n (%)6 (75.0)33 (82.5) CD4 (cells/uL)Mean (SD)590.1 (155.5)652.9 (258.4) Viral load (cp/mL)Median (IQR)17887 (544, 43297)16968 (2228, 52547) Demographic and baseline characteristics
Safety Adverse events Placebo (n=8) H1/IC31 (n=40) All gradesGrade ≥3All gradesGrade ≥3 Solicited local AEs pain, tenderness, erythema, induration, nodules 10620 Solicited systemic AEs malaise, myalgia, headache, nausea, vomiting, athralgia, fatigue, chills, fever 170840 Unsolicited AEs4602512 Total6403972 Local injection site reactions were more common in H1/IC31 versus placebo recipients (65.0% vs. 12.5%, p=0.015) 3 serious adverse events (malaria, perianal abscess and pregnancy with death of premature child): not related to the investigational product No effect on CD4+ T cell count and HIV viral load
H1/IC31 vaccination group (n=20): IFN-γ, TNF-α, IL-2 and IL-17 expressing CD4+ T cells after stimulation with H1 Durable immune response: CD4+ T cell expressing IFN-γ, IL-2 or TNF-α Response independent of CD4 count or QFT status. Data not shown Immunogenicity - whole blood intracellular cytokine assay
H1/IC31 vaccination group (n=20): H1 specific CD4+ T cells expressing any combination of IFN- , TNF- and IL-2 Predominately IFN-γ/TNF-α/IL-2 or TNF-α and IL-2 Poor CD8+ T cells responses. No humoral responses. Data not shown Immunogenicity - whole blood intracellular cytokine assay
Conclusions Safety H1/IC31 was well tolerated and safe in HIV-infected adults, with CD4+ lymphocyte counts greater than 350 cells/mm 3, from TB endemic areas. Similar to safety profiles of previous trials in HIV-uninfected TB-uninfected, BCG vaccinated or latently TB-infected participants. Immunogenicity H1/IC31 induced a persistent Th1-immune response with predominately TNF-α and IL-2 co-expressing CD4+ T cells and polyfunctional IFN-γ, TNF-α and IL-2 expressing CD4+ T cells. Future clinical TB vaccine development Multistage vaccine H56/IC31 will continue in clinical development, might prevent acute TB disease as well as re-activation of LTBI. H1/IC31 data has been and will be used as supportive data. Aagaard C et al., Nat Med. 2011
PI: Gavin J Churchyard Lynn Katsoulis Trevor Beattie Nicolene Gardiner Sponsor: SSI Peter Andersen Søren T Hoff Peter Bang Ingrid Kromann Khadija Said Elirehema Mfinanga Claudia Dauben- berger Nicole Lenz Christian Pohl Benjamin M Kagina Elisabeth J Hughes Willem A Hanekom Thomas J Scriba Katherine L Fielding Hannah Jeffery Funded by the European Developing Countries Clinical Trials Partnership (EDCTP) Acknowledgment
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I've just finished reading her biography, Nancy Wake by Peter Fitzsimons, and, it's a big call I know, but I'm just putting it out there... I have never heard of a more fearless, kick-ass human being in all of history.I first heard of Nancy Wake when she died at the ripe old age of 98 in 2011, and was thrilled when I found out she was a New Zealander, as most people knew her as an Australian, since she moved there as a young child.
I asked dad about her and he told me she was nicknamed "White Mouse" because of her ability to evade capture during World War two. By the end of the war, she was on top of the Gestapo's most wanted list, and she ended up being one of the most highly decorated war heroes of the second world war.
In the early days of the war when France was occupied by Nazis, Nancy helped saved thousands of people by setting up escape routes out of France into Spain, and then, as the war intensified, she was trained as a spy by the British and led 7,000 resistance fighters in D-Day preparations.
She parachuted into France, organised food, clothes and weapons to be dropped from the sky, embarked on a 500km bike ride in 72 hours to get a new radio when theirs had to be destroyed (the radio was their most important weapon - without it they could not continue what they were doing because they couldn't arrange for supplies to be sent from Britain), and basically, she organised a band of soldiers to piss the Germans off so much that they were driven out of France - they blew up bridges, ammunition stores, and attacked German troops unseen and took off back into the mountains.
And they did leave. France was liberated in the end. And after reading about Nancy, I think it would have been a whole lot harder if not for her.
After reading the book, I looked her up on YouTube, and, one video that struck me was one where Peter Fitzsimons, the author, was talking about the book launch, and said that when Nancy was asked to go up and speak, she simply stood up and said, "I've got one thing to say. I killed a lot of Germans, and I'm only sorry I didn't kill more. Thank you." And sat down. A sentence like that just sums her up completely. What a woman.

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The coach can introduce more juggling games once the players are fairly proficient at their juggling with their feet, thighs and head. This is a great way to start motivating the players to try and take it to the next level. I like to relate juggling to a video game - the kids should try and move up the different levels.
I always ask them "what is your favorite video game?" Juggling is the same thing - moving up the levels until the players become more comfortable with the soccer ball.
Are the kids just learning to juggle? Click here and check out basic juggling to learn more.
The kids have a lot of fun with the juggling test like the four minute juggle off. This is also a great way for the coach to measure the skill level of the players.
To start foot juggling...
Scoring: If the player gets 3 juggles and the ball hits the ground they can pick it up and keep going four, five , six...
Encourage the players to use good technique when they are using the foot to juggle the soccer ball - toe out - ankle locked so the ball hits the sweet spot.
Start the game thigh juggling...
Good technique is when the soccer ball hits the thigh and not the knee - the knee will cause the ball to bounce away.
To Start head juggling...
I always show the kids the difference because the ball hitting the top of the head really looks "goofy" and they get a big laugh out of it!!
The players can juggle with anything they want foot, thigh or head in the last game.
You have laid a foundation for the players by doing each of the other juggling skills separately. They will add to this total as they progress.
It can be quite easy for the some players to embellish a little but the coach will be able to tell who has been genuine based on the skill level.
Bring the scores to coach: I now have the kids come in and give me their scores so we can measure where the players are at this particular time.
Testing: I will come back two weeks later and see where the players are numbers wise and see if we have made progress. You can also tell at game time because you will see the touches improving in the soccer games.
Return to Soccer juggling from Juggling games
Apr 20, 17 08:35 AM
Chris Brown and Private soccer training in Round Rock and Cedar Park, Texas
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about Soccer Innovations products
Jan 25, 17 05:44 PM
Dribbling basics in youth soccer for coaches and players U6-U12.
Coaches, do you want to make soccer fun and motivate your players? Soccer patches are a great motivational tool that can be used for goals, assists, good defending or skills competitions. The kids love patches!!


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The company behind Old Speckled Hen and operator of 2,429 pubs across Britain was seen by analysts as a possible "white knight" buyer of Capital, which has made it clear that the 200p a share "indicative" offer from Fuller's is unwelcome.
Chief executive Rooney Anand declined to be specific, but distanced himself from the notion.
"We've just bought a business in London, we've plenty going on. We've got a lot on our plates," he said. That business is Realpubs, 14 premium London pubs recently acquired for £52 million.
Anand said this deal and the Capital Pub bid battle are telling. "What it is showing you is that London is where the action is. People are looking ahead to the Olympics," he said.
In the year to May, Greene King's sales passed £1 billion for the first time, rising 6% to just past what Anand regards as "a landmark".
Profits jumped 14% to £140 million, allowing a 7% rise in the dividend to 23.1p.
Despite the strong results, Anand is cautious.
"I'd love to tell you we are immune from external factors. We aren't. But when our customers have a reason to go out and enjoy themselves, they are really going for it."
He reckons that people who are delaying or abandoning plans to buy a new house or car feel ever more inclined to enjoy a pint.
The Suffolk based firm is 212 years old.
- More about:
- Bars And Pubs
- Intel Corporation
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I am delighted to welcome you to our school website. We hope you find it useful, informative and interesting. The pupils, staff, governors and parents are rightly proud of the school and the exciting opportunities that we offer. Our school motto is 'Children First' and we place that at the heart of all the decisions we make.
Our aim is that, 'By believing in ourselves and working together, we will strive to achieve our full potential in body, mind, heart and spirit.' As you look around the site you will see examples of some of the activities that contribute to this.
You will be able to find out about Lab_13, our In Harmony project, the Secret Garden, Spanish, ICT, sports activities, after school activities, visits & residentials, and much more.
Enjoy exploring the site and getting a flavour of all the great things that happen at Dovecote.
Dovecote is at the heart of its community and we see your child's education very much as a partnership. We want to involve families from before the start of nursery to the tearful farewell at the end of year 6 (and even then they come back!). We look forward to seeing you at parents' meetings, assemblies, concerts, open days, school fairs, and many other events.
Either on the website, or in the pupil planners, we have tried to include all the practical information that you could want to know about our school. If you have a question that is not answered, please get in touch and we will get back to you
March Update
As always, this has been a very busy term.
We have had a number of really successful events, and thank you for your continued support for the school in so many activities.
World Book Day. What a great day that was. There are pictures on this site.
Comic Relief. Over £500 raised. A great effort and a really fun day.
The No Nonsense grammar and spelling parent evening was a great success with well over 50 people attending. We will be running similar, curriculum themed evenings every half term from now on. Always on a Monday with dates to be published soon so you can plan them in.
Easter Activity Day was its usual mix of decorated eggs, bonnets, and broken eggs! You would think by year 6 that they would have worked out that to enter the egg rolling competition, it has to be hard boiled!
Our second In Harmony Spring concert was well attended, and the pupils performed a variety of pieces and songs. If you missed the staff band's rendition of 'Every Body' from the Blues Brothers, you missed a treat.
All this, along with the usual mix of trips, visits, music performances, night walks and Lab_13 events.
We also had the monitoring visit following our inspection last September. The report from this is available in the letters to parent section, as are the results of the recent parent questionnaire.
The last event of the term was the Spring Term achievement assembly. It is always a real treat, and proud moment to recognise the achievements of so many pupils throughout the term. Again, thank you for taking the time to share that with us.
A bit of advanced warning is that the return date for the pupils after the summer break will be Monday 4th September 2017.
Enjoy the Easter break and we look forward to welcoming everyone back on TUESDAY 18th April at 8.45am for the summer term.
December Update
Thank you to everyone for your support for the school this term. It feels like a long time ago now that the Ofsted team turned up. We have worked hard since the inspection and we are confident that when they come to visit (probably next term) for a day to look at the progress we have made on the suggestions they made, that they will be pleased with what they see.
These last few weeks have been very busy as always. It has been wonderful to see so many people supporting all the different events. From the City concert at the Albert Hall, the year 5/6 carol concert at St Mary's, Jack and the Beanstalk from reception and year 1, the year 2,3,4 production, there has been great attendance and support.
We have also had craft days and parties. All well attended and great fun. Santa has been very busy delivering all the books to the children.
We have also had our end of term achievement assembly. Pupils now have to have attendance and punctuality above 98%, as well as impeccable behaviour, good progress, a positive contribution, and always be ready to learn. Despite the raised expectations, we still had over 120 pupils in achievement assembly – a fantastic achievement. The change from vouchers to books as a reward has been really well received by parents, staff and pupils, and this is certainly something we will continue in the future.
Thanks again for all the support. Have a lovely holiday and we look forward to seeing all the children back on Wednesday 4th January.
November Update
Dear families,
As I am sure you know, we recently had a school OFSTED inspection. The report has now been published and is available on the school website. As before, I wanted to share some of the highlights, and recommendations with you.
'Parents and the majority of those who responded to Parent View, and informally during the inspection, expressed their pleasure in pride in being part of the school community.'
'The school has a positive and welcoming atmosphere where pupils get along and are fully accepted and included.'
'The already few incidents of bullying have reduced further. Pupils express their confidence that adults act quickly to deal with bullying,'
'The school promotes pupils' spiritual, moral, social and cultural development well.'
'Children in Nursery and Reception classes continue to make good progress.'
'Pupils eligible for the pupil premium funding make good progress.'
'Behaviour is good, both in and out of lessons. Pupils enjoy learning, and attendance has improved significantly to reach the national average.'
'The school provides good care and support.'
'Pupils who have special educational needs and/or disabilities make good progress. Skilled support is used effectively.'
'Safeguarding is effective.' 'Pupils say they feel very safe in school.'
'Governors have a good range of skills and experience. Governors have high aspirations for the school.'
Like all reports, there are pointers as to how we could improve further,
'Raise pupils' achievement further by ensuring that teachers regularly pose challenging questions,'
'Improve further the progress made by pupils in writing,'
'Make teaching more effective by ensuring that leaders provide teachers with precise feedback about their classroom practice,'
Despite the school remaining in the category of 'Requires Improvement', we were pleased that the inspectors recognized the many improvements since the last inspection.
Andy Jenkins
Ofsted Information 2016
September Update
Welcome back to a new school year. We hope you all had a good summer break. We have had an excellent first week back and are looking forward to another exciting and busy year.
I have listed some key dates so that you can begin to plan around work and childcare.
There will be more details to follow – for example, when exactly the Christmas performances and parties are.
There are also bound to be additional events that we do not yet know about and we will always try and give two weeks notice of these.
Harvest Assembly
Donations for Clifton Food Bank
|Parents' Meetings 3.30 - 6.00
|Parents' Meetings 3.30 - 6.00
17.10.16 to
Fri 28.10.16
|Half Term Break
|Children In Need
|Open Afternoon 1.30 - 3.20
|School Fair 3.30 - 5.00
12.12.16 to
Thurs 15.12.16
|Christmas Performances
16.12.16 to
Tues 20.12.16
|Christmas Parties
|9.15am End of Term Achievement Assembly
|3.20 End Of Term
|INSET Day (pupils not in school)
|8.45am Pupils Return to School
|Parents' Meetings 3.30 - 6.00
|Parents' Meetings 3.30 - 6.00
|World Cancer Day - School Purple Day for Sue
13.02.17 to
Fri 17.02.17
|Half Term Break
|Red Nose Day
|Easter Activity Day
|9.15am End of Term Achievemnet Assembly
|3.20pm End of Term
|8.45 Pupils Return to School
|Year 6 SATs. Full Attendance is Vital
|INSET day (pupils not in school)
29.05.17 to
Fri 02.06.17
|Half Term Break
|01.15pm Whole School Potted Sports
|House Reward Trip for the Winning House
|Summer Fair
|9.15am End of Term Achievement Assembly
|9.30am End of Term Achievement Assembly
|3.20pm End of Term


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Larry Merchant Retires From HBO, Here's An Awesome Tribute Video
Written By: Admin|
December 16, 2012|
Posted In:
Legendary boxing analyst Larry Merchant has decided to retire, and HBO put together an awesome tribute video chronicling his 35 years in the business.
I was surprised to hear this, but Merchant is actually 81 years old. He looks damn good for an 81 year old, so good in fact that he was ready to throw down with Floyd Mayweather Jr. Remember when Mayweather Jr. knocked out an unsuspecting and apologetic Victor Ortiz, and then Merchant called him out on it? It was insane, and in hindsight, it was a fitting way to remember Merchant.
Larry Merchant has spent his career interviewing the toughest men on the planet, and he was never scared to ask the tough questions. To some people, that makes Merchant pushy and annoying. However, I respect the fact that he was willing to tread on thin ice. Merchant never took the easy path in his interviews.
"It is extraordinary to reflect on all Larry Merchant accomplished at HBO Sports," HBO Sports boss Ken Hershman said in a statement. "We've been honored to have him as a colleague and he'll always be a member of the HBO family.
After spending the majority of his adult life sitting ringside at the most influential boxing matches in history, Merchant has certainly earned a break…


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VitaWater – is the largest portal on aquarium and terrarium keeping and backyard
ponds in the Russian language segment of the Internet.
– The fullest on-line encyclopedia on aquarium fish, their food, medical care, plants, drochemistry,
aquarium design, equipment, etc;
– Unique original papers and material on the most important issues;
– Vivid forum and blogs of experienced aquarium keepers;
– Internet store with the richest assortment of products for aquarium and terrarium keeping and
backyard ponds maintenance with delivery all over Russia
– Review of original periodic publications and books on aquariums, terrariums, and backyard ponds.
Of course, for our visitors – the lovers of aquariums and their dwellers, for the owners
of terrariums and backyard ponds.
To them we offer the highest quality product in this segment of the Internet.
The monthly audience of the Internet-portal "VitaWater" is about 300.000 people (according to SpyLog). It is more than the sum of circulations of all publications in the whole zoobusiness.
Number of visitors grows every month.
Number of page views of the Internetportal
has already exceeded 2.000.000
per month (according to SpyLog and
All our regular
audience will not be
able to fit even the
biggest stadium in
the Spain -
Nou Camp.
There just will not
be enough place
for everyone!!!
– Banner adds in various formats on the main and inner pages of the site;
– writing about significant events, product reviews, production of videos;
– including advertising information in the weekly newsletter for subscribers of the Internetportal;
– сompetitions and organization of seminars in Moscow,
St.Petersburg and other regions of the Russian Federation;
– special projects for advertising.
Thank you for your attention!
We will be glad to answer any questions and to help you in organization of
effective for you advertising campaign!
Division for Advertising of the Internet-portal "Vita Water"


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Acid House music and sounds
Listen to the newest Acid House music and sounds.
Acid house is house music featuring a signature squelching, hypnotic bass sound. Acid house was developed in the mid-'80s by DJs in Chicago, Illinois, who were experimenting with the Roland TB-303 synthesizer.
Listen to all tracks and mixes. You have the choice: TECHNO, House, Deep House, Tech House, Electronic, Ambient, Downtempo, Chillout, Electro, Experimental, Minimal, Progressive House, Electronica, Progressive, Minimal Techno, Dub, Deep, Trip Hop, Dance, Deep Tech are the most common styles where artists uploaded their music and sounds.
Other artists of this genre are A Guy Called Gerald, 808 State, Baby Ford, Phuture, Green Velvet, Inner City, Laurent Garnier, Hardfloor, LFO, Rhythim Is Rhythim, Joey Beltram, Kevin Saunderson, The KLF, Model 500, Armando.


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Meeting for suggestions. We are also grateful to the editor of this journal and an anonymous referee for useful comments. Financial support from the Instituto de la Mujer, the FIES and DGES projects PB95-0980 and PB98-1058-C03-01 is gratefully acknowledged. The usual disclaimer applies.
ActiveVessel is a new multimedia workstation which enables the visualization, acquisition and handling of both image modalities, on-and offline. It enables DICOM v3.0 decompression and browsing, video acquisition, reproduction and storage for IntraVascular UltraSound (IVUS) and angiograms with their corresponding ECG, automatic catheter segmentation in… (More)
- J. L. Casado, I. Corral, +4 authors S. Moreno
- European Journal of Clinical Microbiology…
- 2013
To evaluate the situation and perspectives of progressive multifocal leukoencephalopathy (PML) in human immunodeficiency virus (HIV)-infected patients, we investigated changes in the incidence, causes, and long-term outcome of this disease in 72 acquired immunodeficiency syndrome (AIDS) patients who were diagnosed with PML from 1996 to 2011. Patients were… (More)
We gratefully acknowledge financial support from DGES project PB98-1058-C03-03 and from the Instituto de la Mujer, Project VS/2001/0497. Abstract This paper reexamines gender wage differences, taking into account not only worker characteristics but also job characteristics. Consideration of a wide set of " job quality " indicators can explain a fraction of… (More)
We estimate four models of female labour supply using a Spanish sample of married women from 1994, taking into account the complete form of the individual's budget set. The models differ in the hypotheses relating to the presence of optimisation errors and/or the way non-workers contribute to the likelihood function. According to the results, the effects of… (More)
- Elena Valderrama, Mercè Rullán-Ayza, +15 authors Jesús Bisbal
- 2010
Resumen En este artículo proponemos un procedimiento objetivo para la evaluación, basada en competencias, de los trabajos fin de grado (TFG) y de máster (TFM) en el contexto de las ingenierías. Dicho procedimiento se ha dividido en seis etapas: (1) definición de las competencias asociadas al TFG o al TFM y de indicadores objetivos; (2) definición de los… (More)
- J. García, Antonio Gavilanes, A. Gil, Pedro J. Martín
- 31st Annual International Computer Software and…
- 2007
We present a tool that automatically generates the code involved in the solution of problems that are usually posed in a first-year "Introduction to Programming" course; concretely those related to the exploration of recursive sequences. Thus the tool is especially suitable to support teaching and can be also used as a training technique for software… (More)
- J Garcia, D Rotger, F Carreras, R Leta, P Radeva
- 2003
The objective of this work is to segment the human left ventricle myocardium (LVM) in contrast echocardiography imaging and thus track it along a cardiac cycle in order to extract quantitative data about heart function. Ultrasound images are hard to work with due to their speckle appearance. To overcome this we report the combination of active contour… (More)
- J. M. Burgos, J. Galve, J. García, M. Sutil
- 2002
- J. M. Burgos, J. Galve, J. García, J. J. Moreno, Susana Muñoz, D. Villén
- ITiCSE
- 2000
The scope of this work is to serve as support in an introductory programming course. The proposal addresses the problem of how to construct programs from specifications formally and incrementally. As key idea, we use a taxonomy of problem specification schemas, each representing a family of related problems. Actually, the proposal is mainly focused on… (More)


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Pharmaceutical, biotechnology and laboratory industries are challenges with some of the most complex and scrutinized regulations, while also facing competitive pressures to succeed in the global marketplace.
Medical Device manufacturers must use the appropriate documentation that adheres to the standards provided by the Food and Drug Administration's (FDA) guidelines. Intellect offers a highly flexible software solution for the automation of the design process for all medical device manufacturers.
Intellect can help standardize and automate processes for drug safety reporting to meet compliance and to improve operational efficiency with a highly flexible workflow automation solution.
With Intellect, organizations can manage and track all communications concerning product registrations, submissions, and commitments to health authorities.
Give Intellect a try today and see what it can do for your business.


text: NewsUK Grave interest Monday 20 June 1994 23:02 BST Click to follow Staff at a cemetery in Grimsby, Humberside, are to hold their second open day in three months - by popular request. More than 200 visitors attended the first open day, which featured guided tours of the grounds and chapel of rest. More about: Churches Humberside Tourism Yorkshire Reuse content Comments


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Consultants are mystical people who ask a company for a number and then give it back to them.


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(713) 338-8403
Today's river cruise experience is nothing like the historic tales of paddle wheel steamboats on the Mississippi. Modern river cruise ships traverse major waterways across the globe offering river cruise customers a boutique luxury style cruise experience, a relaxed pace of travel, and access to authentic local culture. River cruising is very different from the mega ocean cruise ships, not just because of the size of the ship, but more so for the overall experience. Most river cruise ships offer all exterior cabins, featuring large floor to ceiling windows or balconies, include daily guided shore excursions as well as wine, beer and other drink options at lunch and dinner, and spend most of their time in port docking in the heart of historic cities and small villages along the river.
Selecting the right river cruise for your style comes down to four primary choices – the season, the river, the cruise line, and the cruise ship. That's where it can get more complicated since there are hundreds of river cruise ships and dozens of river itineraries to choose from. And with the popularity of river cruising today, there are new ships and itineraries developed every year.
The river cruise experts at Travel Leaders can help guide you in your selection of the best river cruise vacation for your journey. We have relationships with the top river cruise companies, and can provide inside information on the most popular river cruise itineraries to create a customized experience tailored to your needs. Contact one of our river cruise experts today to start planning your voyage!
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My adventures have taken me throughout Europe, South America, the Caribbean, and Mexico. Before I was in the travel industry I was fortunate to have travel experiences which led me to my passion and into the travel industry. I have been involved i...
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My adventures have taken me throughout Europe, South America, the Caribbean, and Mexico. Before I was in the travel industry I was fortunate to have travel experiences which led me to my passion and into the travel industry. I have been involved in the travel industry since 2009. My travel ideology is to enjoy my experiences through culture, activities, and of course plenty of fun!! Whether you want to enjoy a relaxing river cruise down the Rhine River or enjoying some sun and scuba down in Puerto Vallarta. My experiences have allowed me a broad spectrum not just for personal but also working with a large array of clients in finding their perfect vacation. Vacations should be enjoyable and have moments to remember. I love being a part of creating these experiences and also helping to insure them. Whether your a first time traveler or an experienced excursionist, I can find that first adventure or new adventure with a little help from you. I look forward to working with you and hopefully create some magic with your travel planning!!


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Weather Folklore Does it work?
Red sky at night, shepherds delight, red sky in the morning shepherd's warning True or false?
Why is the sky red at sunset or sunrise? The atmospheric gases scatter visible light from the sun. Blue light (short wavelengths) is scattered more than red light Low sun = long path through the atmosphere. Most of the blue light is scattered right out of the beam – leaving just the red end of the spectrum True
Frontal cloud EAST Cloud moving to the east Red sky at night Frontal cloud Low sun EAST Cloud moving to the east Low sun Red sky in the morning
When swallows fly high, it will be dry True or false?
Why do swallows fly at a particular altitude? | Theyre catching insects to eat | Why do the insects fly at that altitude? | They have little choice – air motions in the atmosphere carry them around | On days with strong heating of the surface, thermals will rise, carrying the insects upwards | So on sunny summer days, the swallows will fly high True
Rain before seven, clear by eleven True or false?
False Late night rain and early morning rain may be the last precipitation of a front passing by. Weather fronts pass just as much in the day as they do at night, so rain in the morning is no predictor of a dry afternoon.
Seagull, seagull sit on the sand, Its never good weather when youre on land True or false?
Seagulls usually sleep on water, but in gusty conditions the water is too choppy. The seagulls then tend to move inland. Therefore…seagulls huddled on the ground are an indicator that the weather out at sea is poor. True
When March blows its horn, Your barn will be filled with grain and corn True or false?
False Blows its horn refers to the occurrence of thunderstorms. Thunderstorms in March indicate it is unusually warm for that time of year BUT it is no indicator of a long term weather trend. Farmers rarely plant their annual crop until May.
When halo rings around the moon or sun, rain is approaching on the run True or false?
True Halos around the moon or sun are caused by refraction of light by ice crystals at high altitude. This high-level moisture is a precursor to moisture moving in at increasingly lower levels, and is a good indicator that an active weather system is on its way.
St Swithin's Day if it do rain, for 40 days it will remain. St Swithin's Day if it be fair, for 40 days will rain no more True or false?
False! The Met Office tested this myth on July 15 th on 55 occasions and on each time 40 days of similar weather did not follow.
When March come in like a lion it goes out like a lamb, when it comes in like a lamb it goes out like a lion True or false?
False! March can be a varied month for weather and just because it comes in strongly at the beginning of the month doesnt mean it will finish any more gently!
True or false? No weather is ill, if the wind be still
True! Calm conditions, indicate the dominance of a high pressure area especially if there are clear skies. High pressure systems tend to give dry conditions but there can be a large amount of low cloud.
True or false? A cow with its tail to the West makes the weather best, A cow with its tail to the East makes the weather least
Unreliable! Cows prefer to stand with their back to the wind so it doesnt blow in their faces. But is a westerly wind a fair weather wind and an easterly wind more unsettled? Lets start with the easterly - the logic is that prior to a low pressure system moving in the wind can (sometimes) turn easterly or at least have a move easterly component so gives a signal of unsettled weather on the way. It is less clear about the westerly as a westerly wind is not necessarily a fair weather wind - there are some occasions when it is and others when it isnt.
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text: Dominic Murphy is a professional artist. Living in Hertfordshire, England. Married with three beautiful daughters. Born in Sheffield England 1963. Studied art at West Surrey College of Art and Design (foundation). St.Martin's School of Art (BA degree in fine art painting). First inspired to paint when he saw the work of Francis Bacon. "When you own a piece of my work you own a piece of me."


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Researchers Use Siri To Steal Data From iPhones 55
wiredmikey writes "Using Apple's voice-activated Siri function, security researchers have managed to steal sensitive information from iOS smartphones in a stealthy manner. Luca Caviglione of the National Research Council of Italy and Wojciech Mazurczy of the Warsaw University of Technology warn that malicious actors could use Siri for stealthy data exfiltration by using a method that's based on steganography, the practice of hiding information. Dubbed "iStegSiri" by the researchers, the attack can be effective because it doesn't require the installation of additional software components and it doesn't need the device's alteration. On the other hand, it only works on jailbroken devices and attackers somehow need to be able to intercept the modified Siri traffic. The attack method involves controlling the "shape" of this traffic to embed sensitive data from the device. This covert channel could be used to send credit card numbers, Apple IDs, passwords, and other sensitive information from the phone to the criminal mastermind, researchers said in their paper.


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Fodors helps you unleash the possibilities of travel by providing the insightful tools you need to experience the trips you want. While youre at the helm, Fodors offers the assurance of our expertise, the guarantee of selectivity, and the choice details that truly define a destination. Its like having a friend in Bangkok!
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• What kids like: royal white elephants in Dusit Zoo, kite flying in Royal Field, boat rides on the Chao Phraya
• Life's pleasures, from Thai massage, to shopping for silk, to a night of bar-hopping
• Side trips to Ayutthaya, River Kwai, and Muang Boran


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Anne Sibert Lecture 2: The Foreign Exchange Market Autumn 2013
The Foreign Exchange Market The foreign exchange market is by far the largest and most liquid financial market in the world. It is many times larger than the next largest market: the US government securities market. Despite its size and importance of the foreign exchange market, it is largely unregulated. No international organization supervises it; no international institution sets rules.
From a 1998 publication by the NY Fed: Individual trades of $200 – 500 million are not uncommon. Quoted prices change as often as 20 times a minute. It is estimated that the world's most active exchange rates can change 18,000 times a day.
Global Foreign Exchange Market Turnover in the Traditional Foreign Exchange Market Daily averages in April in billions of US dollars at April 2010 exchange rates Source: BIS
This is just the turnover in the over-the-counter (OTC) traditional foreign exchange market: the market for foreign exchange spot, forward and swap transactions. It does not include other OTC derivatives. It does not include trading in foreign currency futures and options on organised exchanges. But, these are relatively small.
Reasons for the Changes The fall in 2001 was due to: the introduction of the euro, consolidation in the banking sector, mergers in the corporate sector. The recent rise is more difficult to explain in terms of fundamentals. Perhaps some of the rise is due to innovations in electronic trading that allow high-volume high-frequency trading.
It is a 24-hour market The business day opens in Wellington, New Zealand, followed by Sydney, Tokyo, Hong Kong and Singapore. A few hours later, trading begins in Bahrain. Late in the Tokyo day, markets open in Europe. In the early afternoon in Europe, markets open in the United States. In the mid to late afternoon in New York, markets open in the Asia-Pacific area. Most of the activity takes place when European markets are open.
Geographic Distribution of Turnover (in percent) Source: BIS
London is the largest market London's size as a financial centre is partially due to its historical importance and it relative lack of regulation. London benefits from its proximity to major Eurocurrency markets. London benefits from its time zone: London's morning overlaps with late trading in the Far East and London's afternoon overlaps with New York. Most of the trading in London is done by foreign- owned institutions.
Cross (1998) In the late 1990s about 100 – 200 market making banks where half of most transactions. These were mostly commercial banks and investment banks. They trade with customers and with each other. They were mainly linked through telephones. The old telephone system is gradually moving to electronic trading and 30 percent of all transactions are done online. This allows other financial institutions to trade with each other. Foreign Exchange Market
Electronic Trading Electronic trading offers anonymity, transparency (all prices are shown) and lower costs. Electronic trading platforms are offered by individual banks, groups of banks and by independent companies.
Market Makers A market maker for a currency is a dealer who regularly quotes the rates at which he is willing to buy and to sell that currency. During normal hours, he creates a two-sided market for its customers. He is willing (within reason) to both buy and sell at the rates he quotes. He makes a profit from the spread; that is the difference between the selling and buying rates.
By Type of Reporting Bank's Counterparty (percent)
Other Participants Interbank trading no longer dominates the market. In 2010 only 39 percent of reporting dealers' transactions were with other dealers. Other financial institutions: mutual funds, pension funds, hedge funds, central banks and smaller banks have become much more important. In 2010 48 percent of reporting dealers' transactions were with "other" financial institutions.
Number of Banks Accounting for 75 Percent of the Turnover Banking offices, not organisations. Source: BIS
Top Dealers (in terms of trading volume)
Central Banks Central Banks intervene in the foreign exchange market to influence the value of their currency. Many central banks serve as the primary banker for their government and for other public enterprises. Some central banks (for example, the Federal Reserve Bank of New York) act as agent for other central banks. Some central banks actively manage their foreign exchange reserves.
Currency Distribution of Forex Turnover Because there are two currencies in each transactions, the sum of all percentage shares is 200. Source: BIS
The dollar is the most important currency Many central banks hold the bulk of their reserves in the form of dollars; many central banks conduct much of their intervention in dollars; many international transactions are done using dollars; many contracts are invoiced in dollars. The dollar is the major "vehicle" currency: if a dealer wants to trade Swiss francs for Mexican pesos, he will probably trade the francs for dollars and the dollars for pesos. Only 10% of all transactions involve the euro vs. a currency other than the dollar.
Use as a unit of account About 95 percent of US exports and 85 percent of US imports are priced in dollars. About a third of Euro Area exports and 40 percent of Euro Area imports are priced in dollars.
Types of Transactions Daily averages in April in billions of US dollars Source: BIS
From the Financial Times Currency Australia (A$)0.9826 United Kingdom (£)1.5774 one-month1.5769 three-month1.5760 one-year1.5726 Euro (euro)1.3796 one-month1.3791 three-month1.3786 one-year1.3778
How to read this These are rates taken at an instant in time from one source: 4:00 pm from Reuters. Currencies other than the pound and euro are quoted in currency units per dollar; the pound and the euro are quoted in dollar per pound or euro. For some important currencies we also get the one-month, three-month and one-year forward rates
Def. An exchange rate is the price of one currency in terms of another. A complication is that there are two ways to express any exchange rate. Direct quote: the number of units of home currency necessary to buy one unit of foreign currency - the home currency price of foreign currency Indirect quote: the number of units of foreign currency necessary to buy one unit of home currency - the foreign currency price of home currency
The base currency Suppose the exchange rate is expressed as e units of currency B = 1 unit of currency A (That is, e is the price of currency A in terms of currency B) Currency A is called the base currency. By convention, the euro is the usual base currency against other currencies: the EUR/USD exchange rate is 1.3796. (Note EUR/USD does not mean euros per dollar or euros/dollar) The pound is the usual base currency against all other currencies than the euro.
Triangular Arbitrage Opportunities for triangular arbitrage arise when direct quotations (exchange rates in terms of the dollar - this is another sense of this word) and cross-rate quotations (two other currencies against each other) allow for profit making. This entails using one currency to buy a second, a second currency to buy a third, and a third currency to buy the first.
Example of Triangular Arbitrage Suppose the pound is quoted at 1.6000 dollars per pound. Suppose that the euro is quoted at 1.4000 dollars per euro Suppose that the pound is quoted at 1.0000 pounds per euro. Trade 1 euro for 1 pound. Trade 1 pound for 1.6000. Trade 1.6000 dollars for 1.6000/1.4000 = 1.1429 euros: a profit.
To find what the cross rate must be: Suppose the pound is quoted at 1.6000 dollars per pound. Suppose that the euro is quoted at 1.4000 dollars per euro Then pounds / euro = (pounds /dollar) x (dollars/euro) = (dollars / euro) / (dollars / pound) = 1.4000 / 1.6000 =.8750.
Another example: The Sri Lankan rupee is trading at 108.415 rupees per dollar. The Malaysian ringgit is trading at 3.50580 ringgits per dollar. The cross rate is rupees / ringgit = (rupees/$) / (ringgits/$) = 108.415/3.50580 = 30.9245.
Learn how to compute cross rates Suppose you are given exchange rates for currencies A and B in terms of currency C and that you are told to find the price of currency B in terms of currency A (or equivalently, units of currency A / currency B). First, find the exchange rates for A and B in the form: units of A / units of C and units of B / units of C. Then: units of A / units B = (units of A/units of C) / (units of B/units of C)
The Spread Foreign exchange dealers quote two rates: the rate at which they will buy the currency and the rate at which they will sell the currency. Example: A newspaper may report that the Swiss franc had a central rate of 1.5024 francs /$ and a bid/offer spread of 020 – 028. This means that the two exchange rates were 1.5020 and 1.5028. The dealer would buy dollars (sell Swiss francs) for 1.5020 Swiss francs per dollar. He would sell dollars (buy Swiss francs) for 1.5028 Swiss francs per dollar. When expressed as units of currency per dollar, the smaller rate is the bid rate: the rate at which the dealer will buy (bid for) dollars. The higher rate is the offer rate: the rate at which the dealer will sell (offer) dollars. In the wholesale market (as opposed to the money changers on Tottenham Court Road), the spread is very small. In normal times the spread on the dollar / euro exchange rate is under a pip: 1.3400 – 1.3401 if we are talking about a big transaction between two major banks.
We can find cross rates with spreads In European form: The Swiss franc is 1.5020 – 1.5088 and the Swedish krona is 10.0025 – 10.0075. Find the kronar/franc cross rates. The dealer will buy 1 Swiss franc for 1/1.5088 dollars. He will buy 1/1.5020 dollars for 10.0025/1.5088 = 6.6294 kronar. So, he will buy 1 Swiss franc for 6.6294 kronar. The dealer will sell one Swiss franc for 1/1.5020 dollars. He will sell 1/1.5020 dollars for 10.0075/1.5020 =6.6628 kronar. The kronar/franc cross rates are 6.6294 – 6.6628.
Types of Contracts Spot contracts -- a price and quantity are agreed upon. The two currencies are typically exchanged two business days later. Forward contracts -- a fixed price contract made today for delivery of a certain amount of a currency at a specified future date. The specified date is the settlement date and the agreed price is the forward rate. More precisely, the two currencies are exchanged on an agreed upon date which is a certain number of days or months after the spot date. Thus, a three-month forward contract is conventionally settled in three months plus two days. Typically, no money changes hands at the time the contract is written
Example of a Forward Contract Frank Dollar, the foreign exchange manager at the Big American Automobile Company was informed that the BAAC is importing parts from Japan at a cost of 600 million yen, to be paid upon delivery in two months time. To protect the BAAC from exchange rate fluctuations, Frank Dollar arranged to purchase 600 million yen forward from Mega Bank. The two- month forward price was 120.00 yen/dollar. In two months and two days, Dollar paid 5 million dollars and received 600 million yen.
The Timing of the Contract At time zero: All of the details of the contract were worked out At time zero plus two months and two days: The exchange is carried out.
Eurocurrency Markets Eurocurrency refers to deposits in a commercial bank which are denominated in a currency other than the currency issued by the country the bank is resident in. For example, a bank deposit denominated in dollars in a bank located in London is a Eurodollar deposit. It does not matter whether the bank is Barclays or an American bank.
Historical Background The Eurodollar market arose in the 1950s. The Soviet Union had large amounts of dollars from their oil sales. They did not want to hold them in the United States because of fears that the US would freeze them. They found European banks that would accept their dollars as deposits. It is said that one was a French bank with the cable address eurobank, hence the name. Thus, there arose a large pool of dollars outside the United States and outside the control of US authorities. In 1958 the British government introduced a restrictions on capital flows. British banks tried to get around these regulations by issuing loans dollar loans. Euro markets were particularly attractive because they had far fewer regulations and offered higher yields. From the late 1980s onwards, US companies began to borrow and hold money offshore. British banks found it attractive to make loans in dollars. London is the most important centre.
Covered Interest Arbitrage i = one-year interest rate on (Eurocurrency ) deposits denominated i* = one-year interest rate on (Eurocurrency) deposits denominated in the foreign currency e = spot price of the home currency in terms of the foreign currency f = one-year forward price of the home currency in terms of the foreign currency
An investor has two options He can take one unit of the local currency and deposit it in an account denominated in the local currency. At the end of the year, he will have 1 + i units of the home currency.
He can take one unit of the home currency and simultaneously: buy e units of the foreign currency and deposit it in an account denominated in the foreign currency. This will cause him to have (1 + i*)e units of foreign currency at the end of the year. enter into a forward contract to sell (1 + i*)e units of the foreign currency at the end of the year at a forward rate f. At the end of the year, his account will be worth (1 + i*)e units of foreign currency; he will carry out the forward transaction and end up with (1 + i*)e/f units of the home currency.
There will be arbitrage possibilities unless the two investment activities yield the same amount of foreign currency: Thus, we must have: (1 + i*) / (1 + i ) = f /e. This relationship is called uncovered interest parity
Example Suppose that pound trades at 1.6000 dollars per pound the one-year US interest rate is 1.00 percent and the one-year UK interest rate is 2.00 percent. If you invest one pound you end up with 1.0200 pounds at the end of the year. Or, you can trade the pound for 1.6000 dollars, invest them at 1.00 percent and get 1.6000 x 1.0100 = 1.6160 dollars at the end of the year. If you entered into a one-year forward contract at the start of the year you could sell these dollars for 1.6160 / f pounds. So, it must be true that 1.0200 = 1.6160 / f and thus, f = 1.6160 / 1.0200 = 1.5804.
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Morning Briefing
Scotland Catholic Church in anti-gay marriage stance
Mass at NYC church that was damaged on 9/11
Illinois What's best for kids in Illinois church-state battle?
Australia: An archbishop leading a breakaway Anglican faction that wants to reunite with Rome has revealed that he fled the Catholic priesthood after experiencing systematic sexual abuse over more than a decade.
LOUISVILLE, Ky. A merger that would put Jewish Hospital under the control of Catholic Health Initiatives has raised questions in the Jewish community.


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Theory Kazia Leuna Silk Blend Sweater
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Bold graduated color blocking details enrich this Theory sweater, classically structured in a luxurious wool blend. Alpaca/silk Dry clean Imported Crewneck, long sleeves Contrast color block detail. rich purple tone gently fades into a rich crimson, lending soft depth to this lightweight Theory sweater. A close crew neckline adds classic style, and wide ribbed banding trims the edges. Fabric: Knit. 60% alpaca/40% silk.
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Wikipedia:Don't be evil
|This page is an essay, containing the advice or opinions of one or more Wikipedia contributors. Essays are not Wikipedia policies or guidelines. Some essays represent widespread norms; others only represent minority viewpoints.
The Wikipedia would work a lot better if people weren't evil.
People should not be evil[edit]
If people don't vandalise, RC patrollers could work more on expanding the encyclopedia. If people don't get into lame edit wars and don't breach the 3-revert rule, fewer people would be blocked and they would be able to further edit the encyclopedia. If people are civil, everyone will be happier and fewer people would leave the Wikipedia, hence expanding it further. Editors should be mindful that material in Wikipedia can affect people's lives; adding harmful content is not necessary for improving the quality of the encyclopedia.
Remember still to be bold, and when necessary ignore all rules.
Put very simply: Being good, not evil, helps Wikipedia expand.
Wikipedia must not be evil either[edit]
Also, as with Google's slogan don't be evil, Wikipedia should be mindful of the effect we can have on people and companies. We should not be evil either; this is the philosophy that underlies WP:BLP and it is a good principle. That does not mean acceding to people's demands for vanity articles or mass links to their site, but it does mean doing what we can to ensure that Wikipedia's "Widgetcorp are teh spammerz!" discussion does not dominate their search engine presence. Wikipedia is not here to be part of their marketing machine, but neither are we here to punish them for trying to abuse us as such. Use redirects, courtesy blanking and other common tools, with discretion but always with a mind to allowing them a graceful exit.
Banned users who have used their real names may also be more likely to "scratch the itch" if their vanity searches keep drawing them back to Wikipedia. Talk to any WP:OTRS volunteer about the impact of deletion and internal discussions on real people and organisations. We WP:DENY recognition but we should also not immortalise people's mistakes. That would be evil. Let's not be evil.
See also[edit]
- Don't be evil
- Wikipedia:Five pillars
- Wikipedia:What Wikipedia is not
- Wikipedia:What Wikipedia Is


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|I can answer questions specifically geared towards athletes and their eating issues. I would be able to assist parents or coaches with questions or concerns about disordered eating practices often found in the exercise and sports settings. I also have experience in training and conditioning so I am in a position to discus how the two interrelate.
|I am recovering from about nine years with my eating disorder and while I am not a psychologist, I`ve accumulated a good deal of knowledge about eating disorders as well as my own experience over this time. I`ve mainly struggled with anorexia, but have definitely had times where I have engaged in bulimic behaviors as well. I also struggle with over exercising, but am about to be certified as a personal trainer and have learned moderation as well as how to treat my body well so it can perform at it`s best. I promise to give an honest answer to anything asked, and I want to say that while it is a long, scary road---it is possible to get free of this and it is so important to keep on taking little steps and knowing that you are not alone.
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Conservative super PAC 'endorses' Biden
Rehashing some of Vice President Joe Biden's greatest hits, the conservative American Crossroads PAC released a new Web video urging Biden to "Run. Joe. Run," in a joke endorsement Friday.
"In hard times America needs smart, disciplined leadership, a vice president Americans can count on," the narrator explains, followed by a clip of Biden infamously calling "jobs" a three-letter word.
"Improving race relations," the narrator continues, as the ad cuts to video of a recent Biden speech in which he told a largely African-American audience that Republicans would "put y'all back in chains."
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'Latitude Adjustment' the Perfect Getaway!(31 Reviews)
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- Minimum stay:1-3 nights
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About the Property
Sleeps 8-10. 3 Bedroom 2.5 bath and outdoor shower. With optional boat-slip
Enjoy sitting on the screened porch watching the sunset on the bay, or lounge in the rocking chairs on the back porch while grilling your fresh caught fish. The kitchen is well stocked for all of your cooking needs. The counter height bar seats 6 in addition to the dining table for 8. As an added bonus, there's also a newly built, private, walk-in, outdoor shower complete with hot water and a changing area.... Perfect for wet swimsuit changes or cleaning up before going in for the day!
There are 3 bedrooms:
Master bedroom: king bed
2nd bedroom: king bed and twin bed
3rd bedroom: One twin
One full
One twin over twin bunk
One rollaway twin
Both master and guest face the bay and have french doors that open up onto the screened porch. The bunk room is very kid friendly and can sleep 6.
If you desire to eat outside, the screened-in porch provides you with a great option as well.
A wooden table seats ten, or enjoy eating on the relaxing furniture, swing or rocking chairs on the other side of the porch. You can enjoy a wonderful candlelight dinner at the table or just hangout on the swing and watch for shooting stars, fireworks or just look at all the lights across the way. The back porch houses a stainless, charcoal grill where you can prepare your fare. It has a table for 4 and rocking chairs to enjoy a morning cup of coffee while watching the resident blue heron family or the sounds of nature.
An extra fridge in the laundry room is available for use, if needed. All bathrooms as well as the linen closet is amply stocked. You'll find plenty of games, cards, a Wii game system, books, 3 youth kayaks, an adult size tandem Kayak, scooters, swings and a hammock to entertain the whole family.
If crowds are what you need, the Gulf of Mexico, with its' sugar white sandy beaches, is just a short drive away. The faster pace of Gulf Shores and Orange Beach is close, but not too close, and offers great restaurants, sightseeing, attractions and shopping. Pontoon and speed boats are available for rent and fishing boats can be chartered for off shore and in shore trips at many of the marinas. Para sailing, Dolphin tours and sailing are also available. If shopping is your thing the Tanger Outlet is just a short 20 minute drive away in Foley.
Come enjoy easy living, and leave feeling decompressed, rested and rejuvenated!
When you're ready to book, here are some tips to keep in mind.
Paying with a credit card on VRBO protects your payment for up to $10,000 against listing fraud. We recommend completing your booking on VRBO.Verify your payment method
Member since: 2014
Property Type
- House
- 1800 sq. ft.
House Rules
Accommodation Type
- Vacation Rental
- Guests Provide Their Own Meals
- Long-Term Renters Welcome
- Wheelchair Inaccessible
Bedrooms: 3 Bedrooms, Sleeps 10, Beds for 10
- Bedroom 1: 1 king
- Bedroom 2: 1 king, 1 twin/ single
- Bedroom 3: 1 double, 2 twin/ single, 1 bunk bed
- 3 Bedrooms, Beds for 10. 1 Child sleep guard rail. 2 toddler sleeping blow up mats. ...moreless
Bathrooms: 2 Bathrooms, 1 Half Bathroom
- Bathroom 1: toilet, shower, jetted tub
Bathroom 2: toilet, combination tub/shower
Guest bathroom located between Guest room and Bunk room...moreless
- Bathroom 3: toilet
Bathroom 4: outdoor shower
Lg enclosed outdoor shower w/hot water & changing area...moreless
- 2 Bathrooms, 2 Half Bathrooms
Other Amenities
- Adventure
- Away From It All
- Family
- Romantic
- Sports & Activities
- Tourist Attractions
- Churches
- Cinemas
- Festivals
- Health/Beauty Spa
- Library
- Live Theater
- Marina
- Playground
- Recreation Center
- Restaurants
- Water Parks
- Zoo
Local Services & Businesses
- ATM/Bank
- Babysitter
- Groceries
- Hospital
- Laundromat
- Massage Therapist
- Medical Services
Leisure Activities
- Antiquing
- Beachcombing
- Bird Watching
- Boating
- Horseback Riding
- Miniature Golf
- Outlet Shopping
- Paddle Boating
- Photography
- Scenic Drives
- Shopping
- Sight Seeing
- Walking
- Wildlife Viewing
Location Type
- Beach View
- Beachfront
Sports & Adventure Activities
- Basketball Court
- Cycling
- Deepsea Fishing
- Fishing
- Fly Fishing
- Freshwater Fishing
- Golf
- Hunting
- Jet Skiing
- Kayaking
- Parasailing
- Pier Fishing
- Sailing
- Scuba Diving Or Snorkeling
- Snorkeling
- Snorkeling/Diving
- Sound/Bay Fishing
- Surf Fishing
- Surfing
- Swimming
- Tennis
- Water Skiing
- Water Tubing
- Wind-Surfing
Indoor table seats 8 comfortably, breakfast bar seats 6, back porch table seats 4 and front screened porch table seats 10. ...moreless
- Dining Area
- Seating for 8 people
- Air Conditioning
- Clothes Dryer
- Hair Dryer
- Heating
- Coffee Maker:
- Dishes & Utensils:
- Dishwasher
- Kitchen
- Microwave
- Oven
- Balcony:
Deck / Patio:
front porch is screened in overlooking bay, back porch is open overlooking dock, creek and swimming area. ...moreless
- Golf:
Kayak / Canoe:
3 youth size kayak and one adult tandem available fee may apply...moreless
RatesCurrency Conversion
|Weekend Night
|Monthly *
Spring 2017
Mar 20 - May 25, 2017
3 night min stay
summer 2017
May 26 - Sep 3, 2017
3 night min stay
Fall 2017
Sep 4 - Nov 26, 2017
3 night min stay
Winter 2017
Nov 27 - Mar 4, 2018
3 night min stay
Additional information about rental rates
- Refundable Damage Deposit $300
- Pet Fee $250
- cleaning fee $200
- Tax Rate 10%
Prices subject to higher rate during holidays and special events.
Note: Until confirmed, rates are subject to change without notice.
Check with owner on monthly rate discount. Snowbirds welcomed!
Boathouse and slips subject to availability. Check with owner.
Owner's cancellation policy:
50% refund for cancellations more than 14 days before check-in date.
100% refund for cancellations more than 30 days before check-in date.
Don't forget your vacation protection! Get protected now
Adding our Vacation Protection services can make sure your getaway goes smoothly, no matter what. We offer Cancellation Protection and Damage Protection so you can truly relax.
Car: Recommended
Owner info
Contact us
Send email
- Primary: 9045373260
Links to more information:
- Click Here to see All My Rental Listings
another beautiful sunrise
Back porch
Kitchen with everything you need to cook with.
Dining area seats 8-10
Screened in front porch overlooking Perdido Bay.
Master bathroom
Boathouse and dock
a little time for fishing, crabbing and exploring
another beautiful sunset
Back porch grilling area
Eat at bar seats 6
Open living area
Laundry room and extra freezer
Eating area on front screened porch
Guest room
A little time for swimming and having fun off the dock
Master bedroom
This listing was first published here in 2014.
Date last modified - Friday, April 28, 2017
Partner Offers
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California Wild Rice and Zucchini Pancakes
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text: Australia Underwater Hockey 61,318pages on this wiki Add New Page Edit History Talk0 Share ????–present Retrieved from "http://logos.wikia.com/wiki/Australia_Underwater_Hockey?oldid=738521" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Australia Underwater Hockey


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Published on July 14th, 2016 | by Manisha Surange0
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The demise of the humble house sparrow, whose plight has been highlighted by The Independent and is now cited by the Government as an example of environmental degradation, appears to have been reversed in Scotland.
As numbers of the once common bird continue to fall across most of the UK, a new survey by the British Trust for Ornithology has discovered a surprising rise in the species' fortunes north of the border.
In the past 25 years house sparrow numbers in the UK have fallen by about two-thirds with many populations completely vanishing from large cities. In 1925, one of the 20th century's leading ornithologists, Max Nicholson, recorded 2,603 sparrows in Kensington Gardens, London. Fifty years later a similar survey found numbers had fallen to about 500 and by 1995 that was further reduced to 81. When Mr Nicholson returned last year for the 75th anniversary of his first count, no sparrows were found,
There has been increased pressure on sparrow populations across Europe but many of Britain's biggest cities seem to have been hardest hit.
Reasons for the decline are unknown but theories on why the bird most associated with human habitation and activity should be disappearing include the increased use of pesticides, traffic pollution, climate change and even modern building techniques, which leave no holes or crevices for the birds to nest.
The new survey by the trust's Garden Bird Watch programme suggests that efforts can be made to ensure the species does not disappear altogether.
One possible reason for the rise in numbers in Scotland last year may be down to greater awareness by the public and increased efforts to help the birds. Many home-owners have responded to pleas for help by building nesting boxes, providing bird feeders full of peanuts and seeds, cutting down on pesticides and growing plants that attract small insects, thereby giving the sparrows a breeding boost.
Andrew Cannon, of the Garden Bird Watch programme, said: "There is still a lot to be done. There has been a fall of 5 per cent in sparrow populations across most of the UK between 1994 and last year.
"Only in Scotland has there been a slight upsurge, with a 17 per cent rise in numbers over the last year. However much good news it is, it does not even begin to compensate for the decline of the last 30 years."
The trust's scheme, which relies on the observations of volunteer bird watchers across the country, is anxious to discover at which point during the sparrow's life cycle the bird begins to suffer so that causes and solutions can be identified.
Mike Raven, the national organiser of the trust's Breeding Birds Survey, said: "Between 1994 and 2000, there was a 50 per cent decrease in sparrows in London and a 20 per cent decrease in other regions of England." Scientists are studying the house sparrow's decline as part of a government research contract announced late last year.
"During the same time, there has been a total 27 per cent increase in numbers in Scotland. We don't know why Scottish numbers are increasing while the South is losing its sparrows but the picture is the same for many birds.
"Overall, in the last six years, there have been more species showing an increase in numbers than those decreasing. But over the longer term, say the last 40 years, the figures show otherwise.
"Obviously a change in farming practices can account for much of the damage done to species such as the partridge, lapwing or skylark, but we can't so easily identify the problems faced by the sparrow."
* The Independent continues to offer a prize of £5,000 for the first paper published in a peer-reviewed reputable scientific journal, which, in the opinion of our referees, convincingly accounts for the disappearance of the house sparrow from Britain's towns and cities.Reuse content


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