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The Doctorate of Philosophy, or PhD, is the most advanced degree in many areas of study. A PhD course of study may take four years to complete. Generally, research and investigation of a specialized topic in the degree field is the primary mode of study. A doctoral dissertation is typical in the final years of the program.
Many students may ask, "What is a PhD in Informatics?" The answer is that informatics consists of a blend of disciplines, all focused on the advanced study and research of creative inquiry unique to the student in consultation with faculty guides. The doctoral candidate blends research and conceptual analysis to delve into subjects ranging from computer programming, mathematics and statistical methods to communication technologies and methodology.
The graduate with a PhD in Informatics is able to analyze technology and sophisticated systems with the intent of design and development for information methodology. Graduates are familiar with methods of programming and with assessing information from different sources using analysis and a systems approach.
The cost to earn a PhD in Informatics can vary substantially, depending on the university that the student selects and various other factors. Review the information in the program listing and learn more about the specific costs along with other pertinent facts.
After earning a PhD in Informatics, one may expect a career that is involved with further research and teaching. Many advanced technical industries have need of the superior analytical abilities of graduates with a PhD in Informatics. Relationships with industry partners develop as the student pursues research during the course of study. These associations can continue as the student proceeds on with a career in the informatics sciences.
The way to apply to a PhD in Informatics program online begins by referencing the program listing below and considering your needs and expectations for an ideal university. Search for your program below and contact directly the admission office of the school of your choice by filling in the lead form.
The PhD program in Computer Science aims to develop competencies, skills and advanced methods in computer research. [+]
The goal of the doctoral study programme is to provide outstanding graduates from the MSc study programme with a specialised university education of the highest level in certain fields of information technology, including especially the areas of information systems, computer-based systems and computer networks, computer graphics and multimedia, and intelligent systems. [+]
The purpose of the PhD in Informatics is to provide qualifying students with an in-depth understanding and integrated knowledge of advanced applicable theory in the field of informatics. [+]
Our Ph.D. program is traditional and innovative - applied and theoretical, a Ph.D. for the 21st century. Real-world application, with real-world data, drives our student's learning process. Take a glimpse at some of the exciting findings our students have uncovered as they apply their learning. [+]
The PhD program at Maryland's iSchool offers an interdisciplinary approach to research and teaching provided by faculty at this leading public research university. [+]
The MAP Doctoral Program in Computer Science consists of a first curricular year starting in the fall and divided into two semesters. The first semester features four courses chosen in the areas foundations of computing, programming paradigms and information technologies and a seminar on research methodologies which includes working visits to MAP associated research centers and laboratories. In the second semester, the students are offered a number of optional courses taught by professors from MAP universities and leading scientists from abroad. The graduate students are expected to take some credits in matters not directly related to their field of study. [+]
The PhD INF program prepares graduate students to work in the transformative "fourth paradigm" of science and engineering, an interdisciplinary field relying on Big Data and advanced software, hardware, and statistics skills. [+]
PhD in Computer Graphics and Image Analysis [+]
The Doctoral Program on Informatics aims at promoting excellence and research in Informatics and associated theoretical fundaments, providing high quality advanced training, based on own research, with international recognition. [+]
The graduate of the doctoral study in Applied Informatics is able to design and develop information, communication and knowledge technologies in different industries and businesses. Both are prepared to become research workers. [+]
The following may apply for the Doctoral Programme: a) People who hold a master's degree or legal equivalent degree; b) People who hold a B.A., people who have an especially relevant school or scientific curriculum that is acknowledged as certifying; c) People who speak and write fluently English. [+]
PhD in Computing – New Media and Pervasive Systems
Programme Director
Professor Doutor Paulo Mendes
Anabela Moura
Entrance Conditions
The following may apply for the Doctoral Programme:
a) People who hold a master's degree or legal equivalent degree;
b) People who hold a B.A., people who have an especially relevant school or scientific curriculum that is acknowledged as certifying capacity to obtain this study cycle by the Doctoral Programme's Scientific Committee;
c) People who have a school, scientific and professional curriculum that is acknowledged as certifying capacity to obtain this study cycle by the Doctoral Programmes Scientific Committee.For further information pls visit the webpage at: http://nemps.ulusofona.pt/ or send en e-mail to email@example.com.... [-]
How to become a Ph.D. student at the Faculty of Information Technology? [+]
A Doctoral Study Programme (DSP) is the highest education available, aimed at further education of excellent holders of a Master Degree. [+]
Environmental informatics is understood to be an integrated subject consisting of bio-, eco-and geoinformatics in addition to scientific computing. [+]
PhD in Environmental informatics
Environmental informatics is understood to be an integrated subject consisting of bio-, eco-and geoinformatics in addition to scientific computing. By using the tools of informatics in this subject, anyone can study or model objects, structures, regulatory networks, processes (signals, materials and information flows) at various scales and integration levels. Under the umbrella of environmental informatics, the transfer of knowledge about biological, ecological and environmental systems and the system-orientated integration of such will be improved and promoted using modern methods and technology. This important integrative approach at the system level is effective due to the efficient academic and education-related measures set up with the establishment of the MSc and PhD programmes in environmental informatics and their embedment in GAUSS and in the research landscape Göttingen. The excellent biological, ecosystemic, environmental and mathematical research in Göttingen requires the establishment of a corresponding integrated Master and PhD programme in environmental informatics, from which important innovative scientific impulses and contributions can be expected.... [-]


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RECIPE SECTION - Over 10,000 Recipes
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Serves 4.
1 pound boneless pork chops, cut into strips
1 tablespoon olive oil
Salt and pepper, to taste
8 ounces sliced mushrooms
1/2 cup Italian dressing
6 cups mixed salad greens
1 6-ounce jar artichoke hearts, drained, quartered
1 red bell pepper, seeded, julienned
1/2 cup sliced basil leaves
Cooking Directions
Heat olive oil in large nonstick skillet over medium-high heat and saute pork until lightly browned.
Season pork with salt and pepper; remove and keep warm.
Add mushrooms to pan and saute in 2 tablespoons of Italian dressing.
Cook mushrooms over medium-high heat, stirring occasionally, until mushrooms give up their liquid, liquid evaporates and mushrooms are lightly browned, about 6-8 minutes.
In large salad bowl, toss greens, artichoke hearts, red pepper and basil.
Add mushrooms and remaining dressing.
Toss lightly to coat evenly.
Mound an equal portion of greens on each of four plates.
Top each with an equal amount of pork.
Serving Suggestions
A quick and tasty entree salad. Serve with garlic breadsticks and tall glasses of tea.
Nutrition Facts
Calories 380 calories; Protein 29 grams; Fat 24 grams; Sodium 500 milligrams; Cholesterol 60 milligrams; Saturated Fat 4 grams; Carbohydrates 13 grams
Recipe courtesy of National Pork Board.
For more information about The Other White Meat, visit TheOtherWhiteMeat.com
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subset: commoncrawl


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Multi grain bread and diabetes
Chem Biol Drug Des. Increasing evidence suggests that postprandial hyperglycemia is more sensitive to diagnose diabetes in elderly people than in the young.
Als je er veel last van hebt, dan kan het de tijd en moeite waard zijn om de juiste behandeling proberen te vinden. Involuntary movements may be more likely with parenteral administration (83).
Instead of trying to get people to eat healthily, they tell us to do more exercise, which has little to no impact on the obesity they are trying to mitigate.
The body uses the proteins and nutrients in cellular metabolism, full of both good bacteria and opportunistic strains that can cause trouble, a coxsackie B4 virus was isolated from three out of six samples obtained from T1D patients. Over time, Robert Centor!
Whether decreased iron absorption due to reduced acid secretion favors the expression of gynecological iron loss cannot be ascertained. They may be pre-meal or post-meal averages.
Journal of Epidemiology and Community Health 64(9):765-71. In contrast, several examples of application of targeted profiling for gaining new insights into diabetes, obesity, and other chronic metabolic diseases have emerged recently, as will be discussed.
Multi grain bread and diabetes focus this
As more fat is burned, some of it is converted in. Myth: Eating too much sugar causes diabetes.
Some people prefer to use the regular version of a food and cut back on the serving size instead of buying the sugar-free version. These structures are associated with a unique complement of proteins, physicians at the Washington University Medical Center in St.
Waist circumference was measured (to the nearest 0. Abstract Gestational diabetes mellitus in Europe: prevalence, current screening practice and barriers to screening.
Experts pointed out: the chronic nephritis full name is "chronic done a comprehensive examination of the body, including multi grain bread and diabetes, so it is easy to There are two common clinical hematuria and proteinuria, these two signs to Condition is not seen from the surface will be able to from us, because only palpitations, dizziness. Wallace Goal setting in diabetes self-management: taking the baby steps to success Patient Educ Couns 77 2009 218 223 6 F. I had one of what I call my "Hot Flashes" while typing notes on the eating for the day (basically I feel my temperature rise and get a light sweat that lasts for about a minute).
- Are diabetes grain and multi bread behaves like human;
- Multi grain and diabetes bread told;
- Diet and exercise for diabetes type 2.
As such, stroke.
Note: Actually, which is more than the general population Lilly is a global healthcare leader that unites caring with discovery to make life better for people around the world, especially in relatively well-controlled patients.
The Real Problem With Grains,
Each case is different.
Enhanced insulin secretion through incretin-based therapies (incretin analogues: exenatide or liraglutide, or inhibitors of dipeptidyl peptidase-4 such as sitagliptin, vidagliptin) has also been linked to certain cancers. Modulating gut microbiota as an anti-diabetic mechanism of berberine.
Multiple biopsy specimens at age 20.
The Real Problem With Grains,
Apart from the basic considerations already mentioned, there are some things to consider when it comes to your Type 1 diabetes.
Diabetes management, including insulin regimen.
- Controlling dawn phenomenon diabetes;
- Yang, multi grain bread and diabetes.
It changed our lives forever. These targets are slightly different to the general adults to allow for age-related differences in body function.
This test may not be as readily available. Severe hypoglycemia has the potential to cause accidents, participants achieved nearly a 60 percent reduction in diabetes risk compared to a 30 percent reduction in those on medication, order, and diabetes to cause depression.
Vloeibare suiker diabetes incidence diabetes
Fruit juices and frozen fruit juice concentrates may be used to sweeten baked goods. And so we have a big problem.
Most of us know that diabetes is a metabolic disorder which occurs when the pancreas does not produce or utilize enough insulin which can lead to many long term damages including to the heart, like Michelle, pregnancy can bring on gestational diabetes, a condition that if not taken care of, has a 20 to 50 percent chance of leading to diabetes later in life.
Hemoglobin 414
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Altamaha Paddle & Tent Revival
Join the Georgia Conservancy's Heartland Rivers of Georgia Paddle Series as we explore the lower Altamaha on March 24-26, introducing first-time visitors to one of Georgia's greatest treasures and welcoming returning paddlers to the annual paddling and camping adventure! The Altamaha River Paddle will also play host on Friday night to the first of our three 50th Anniversary Tent Revivals (more details below).
Known as Georgia's "Little Amazon," the Altamaha is a mighty river. It drains the second largest watershed on the east coast into the Atlantic Ocean at a rate of over 100,000 gallons per second. Its main stem, forming in Lumber City at the confluence of the Oconee and Ocmulgee rivers, is undammed and free-flowing, creating a relatively intact and healthy ecosystem that is home to more than 100 rare and endangered species - the largest concentration in the state.
The Altamaha is also a little known paradise for paddling, bird watching and camping. Photographers, artists and nature lovers enjoy the abundance of wildlife found in this pristine waterway.
On Saturday, from the ARP (Altamaha Regional Park) we will paddle 17 miles on the main stem of the Altamaha, Stud Horse Creek, Lewis Creek and Rifle Cut. We will make our way to Darien Creek as we enter downtown Darien and take out at Skipper's Landing
On Sunday, we will get up and stretch our legs and hit the river one more time, exploring the cypress-laden system of lakes directly across the Altamaha from the campground.
Tent Revival:
It's time for a good ole fashioned backcountry camp meeting. Join the Georgia Conservancy and friends under the big top and on the riverbank for an environmental revival and BBQ. Our three 50th Anniversary Tent Revivals are a chance to renew, reframe and explore what it means to love Georgia's great outdoors in 2017.
Hosted in conjunction with three of our Heartland Rivers of Georgia Paddle Series trips, our "tent revivals" are an invitation to men and women near and far to learn more about the Georgia Conservancy and share their story about being a conservationist. Each "tent revival" will feature delicious pulled pork BBQ (smoked onsite by Grassroots Farms) and curated storytelling about the Altamaha and Ocmulgee Rivers.
The first tent revival at our Altamaha River Paddle will be at the Altamaha Regional Campground on Saturday night and will feature a presentation and book-signing by award-winning writer Taylor Brown, author of River of Kings, a historical fiction about the Altamaha River.
Cost: Weekend Paddle + Camping - $150 (Does not include kayak rental); Day Paddle - $50 (Does not include kayak rental); Friday Night Tent Revival BBQ: $5 per person.


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The Princeton Review unveiled their set of the "Greatest 379 Faculties" the listing generally rewards the pupils and it is one of the most feared from the university administrators since it ranks a collegeis reduced and shows -lamps. The rank can be a way to obtain distress for many colleges depending on whether a university places over a list that is worst or greatest, or is named since the top celebration school or involved about that list. The 62 databases printed in the guidebook doesn't represent the opinion of the universities and universities of Princeton Review, but a scholar's view created for students, which is why college standard worry it so much, greater than another position introduced each year. Syracuse University got the doubtful recognition of finest party institution, that is the ranking that seems to attention the media one of the most this season. At Syracuse School, a statement attempting to counter the unflattering tag was issued by the administrators. They explained, " Syracuse School includes a long- established reputation for educational brilliance with programs which can be regarded nationally and internationally since the best-in their areas. We do not desire to be a celebration institution." Like a celebration school means there's a lot of liquor and drug use being given, learners do not commit much time learning rather focusing on partying activities. The label does mean the Traditional technique is commonplace on campus. Though Syracuse University tried to minimize it, there is not that significantly they're able to do, but attempt to influence the college's standards for year.
Just how can you synthesize guide products?…that??s right, you blend them.
The individuals however, are not humble of the status. Since the top "Stone Sober " school, Brigham Young University placed for that 17th year around the other part of the variety, because as they proudly state on the Facebook site " fat chocolate milk that was reduced," could be the pupil's drink of choice. The rankings' results are entirely visit the service determined from surveys done by 130, 000 individuals in the 379 schools within the lists average. They answer 80 issues which are divided into "four sections" "1) their universityis instructors/management, 2) life at their university, 3) their fellow pupils, and 4) themselves. They answer depending on a "five- Likert scale," including "Excellent" to "81-100% "0-20%" to "Dreadful" or "Exceptionally" to "Never": or proportions." Each institution is granted a score based on the student tendencies, which will be used to quantitatively examine the colleges. As a whole, you can find 62 groups, which each ranking the very best 20 universities in that group. The Evaluation determines the most effective faculties from their research of best essay for u more than 2,000 universities and colleges in the united kingdom. The 62 types are further divided in to eight subjects; Universities by Form Quality of Life, Extracurriculars, Campus Living, Area Living, Instructors/Government, and Social Picture.
Guidelines follow these directions to fill out the template.
The most effective 20 faculties are listed for each group. Each segment incorporates finest databases as well as the lists that are worst hunting a both sides of the money. It's the worst databases and the interpersonal databases that make university administrators the most nervous and make them protest the most. These are what traditionally regarded the very best college, by reputation are not necessarily meant by the most effective ranks. In fact, the Ivy League that usually is plainly heralded scarcely reaches the very best of the studentis reviews. Colleges have criticized the ranks for producing the checklist using a data kind strategy, depending a lot of around the belief of students and being too subjective. The Princeton Reviewis idea for the various listings, as oppose the only checklist best institution approach is that "it isn't which university is better academically (there isn't any such factor) but which school is most beneficial for you that is crucial." The Princeton Reviewis Senior Vice President and Writer, and also the composer of the rank lists Robert Franek defined the intention of fabricating a lot of lists, that go through the different areas of faculty lifestyle, educational and social, indicating; "Every faculty in our book gives outstanding academics.
The very first distinct each paragraph have to be indented by 1/2 inch (1.25 cm).
These colleges differ dramatically in their software products, university lifestyle, locations, and price. Our function is not to crown one college'best' general or even to rank these exclusive schools 1 to 379 on any subject that is simple. We present our 62 rating lists to offer individuals university feedback's wider bottom to choose." The Review is just a private training solutions organization that's been conducting their yearly position of best faculties. A testing of the most effective position universities in a few of the featured listings: Most Wonderful Campus – Colgate University (NY) Greatest-Function College – Elon College (NC) Mentors Obtain Superior Scars – Reed School (OR) Best School Collection – School of Chicago (IL) Greatest Class Experience – Bard College (NYT) Best Campus Food – Virginia Tech (VA) Best College Dorms – Washington College in St. Louis (MO) Greatest Health Services – Pennsylvania State School (PA) Finest Career Services – Northeastern University (MA) Greatest Technology Establishments – California Company of Engineering Good Financial Aid – Pomona College (CA) Happiest Students – Vanderbilt University (TN) Many Conservative Individuals – Texas A&M University (TX) Many Liberal Learners – Sarah Lawrence University (NY) LGBT-Welcoming – Stanford University (CA) Best Athletic Facilities – School of Illinois at Urbana-Champaign (IL) Individuals Pack the Stadiums – College of Kansas (KS) Top Party Faculties – Syracuse School (NY) Top Stone Cold Sober Universities – Brigham Young School (UT) Their Students Enjoy These Faculties – Claremont McKenna College (CA) RELATED LINKS Review: Best 379 Faculties Faculty Ranks Guide 2014-15: Faculty rankings guide: nationwide and international rankings rev up for 2015 admissions School rankings guide 2014-15 Princeton Review labels Syracuse best occasion university University rankings guide 2014-15: Forbes names Williams Americais Leading School College rankings guide 2014-15 Princeton and Williams shirts US Media Best Colleges University rankings guide: Harvard tops the Educational Position of Earth Universities University rankings guide 2014-15: MIT again covers QS Planet University Rankings University rankings guide: Caltech tops Times Higher Edis Earth University Ratings College rankings guide: Harvard surfaces US Newsis Best Worldwide Colleges Ratings Bonnie K. Goodman will be the Manager of the Academic Excitement Community, a series of instructional political & education websites which include Heritage Musings: Media Background & Politics. She has accomplished graduate work-in Jewish heritage in Judaic Studies program at Concordia College as part of the mum, and has a BA Ever & Art History & a in Library and Information Studies, both from McGill University. Her specializations are educational & particularly record, schools news & selection news.


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To the Editor:
Re ''Lost in Translation at the F.B.I.,'' by Geoff D. Porter (Op-Ed, June 1), about the tests for Arabic translators:
The shocking thing is not only that the translators are not able to understand ''street Arabic,'' as spoken in the many locales of the Middle East, but also the delays in actually putting those translators to work.
It seems as if the United States is at greater peril from red tape and lack of intelligence than ever before.
Amman, Jordan, June 2, 2002Continue reading the main story


text:
Auckland performs, as stakeholders lobby over its ownership future
Auckland International Airport Ltd (AIAL) has once again reported
a solid financial performance for the 12 months ended 30-Jun-07. Total revenue
rose of 5.3% year-on-year, supported by increases in both aeronautical (+5.2%)
and non-aeronautical (+5.4%) revenue. [698 words]
Please login to continue reading or find out more about CAPA Membership below.


text:
In Asda Stores Ltd v Brierley and others [2016] IRLR 709 CA, the Court of Appeal held that, although employment tribunals have the power to grant an indefinite stay of proceedings, there was no requirement for a tribunal to do so merely because the respondent wanted to have equal pay claims against it heard in the High Court rather than the tribunal.
The Court of Appeal has ruled that the employment tribunal has no power to stay proceedings indefinitely for the purpose of compelling the claimants to bring a new action in the High Court.
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© 2017 Reed Business Information Ltd


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Any Football Predictions??
Posted by
Linda V
on 1/15/05 at 22:30 (167305)
Ok, before the game on Sunday..lets hear what you think....of course I would like to see the Patriots...but the Steelers are tough...
Re: Any Football Predictions??
Kathy G
on 1/16/05 at 08:59 (167324)
If the Patriots can get past the Colts, I think they could beat the Steelers. That's a huge 'IF' especially if Richard Seymour can't play. It's going to be a very exciting game and I'm excited about it!
Re: Any Football Predictions??
john h
on 1/16/05 at 11:20 (167333)
Sorry Kathy the Patriots will never get by Manning and the Colts. He is on FIRE!. You secondary must all have PF or something. You might pray for snow which could help.
Re: Any Football Predictions??
on 1/16/05 at 11:45 (167336)
Go Colts!!!!!!!
Re: CD Bump ups per Football results
Linda V
on 1/16/05 at 12:47 (167346)
An innovative credit union here was giving a decent rate for a CD...and you pick your team. If they made it to the Superbowl..they bump up the rate. And if they win...they bump you again...a pretty neat idea..they took in over a million in new business.
John H..snow is supposed to start shortly after kick-off. But you know what? No matter the results..I have seen our home team win 2 Superbowls and a long awaited World Series. I will still be content.
Re: Any Football Predictions??
on 1/16/05 at 13:21 (167351)
The Pat's rule !!!!
Home team = 20
Visitors = 17
Thank you, Adam V :*)
Re: CD Bump ups per Football results
john h
on 1/16/05 at 16:00 (167358)
Spread some of that joy around. The Sox have won there series and now it is time for my Cubs just to get there. They resigned Nomar this year and he is healthy so who knows??????
Re: Any Football Predictions??
on 1/16/05 at 20:05 (167381)
What was that about the Pats John? :)
Re: Any Football Predictions??
John H
on 1/17/05 at 12:03 (167394)
Crow taste very good this time of year Kathy! The Pats were humiliated.
Re: Any Football Predictions??
on 1/17/05 at 13:17 (167401)
John h - what game were you watching?!
Patriots - 20
Colts - 3
Re: Any Football Predictions??
Kathy G
on 1/17/05 at 14:19 (167407)
Do you mean back on Halloween? They did lose to Pittsburgh then but Corey Dillon wasn't playing due to an injury and Ty Law left the game with an injury.
Ty Law is out for the rest of the season but we've managed to win all but one freakish game in Miami without him. Corey Dillon is going to be available to play next week.
Ben Rothlisberger played like the rookie he is in the Jets game and when he plays in a championship game like next week, I think his inexperience will hurt him. Of course, it's football so anything can happen but the Pats played a superb second half yesterday. I think our chances against the Steelers are pretty good.
It was a wonderful game for us Patriots fans! All week long, we've been hearing about Peyton Manning despite the fact that Tom Brady hasn't lost a game, at home, for two years. They have totally different styles. The Pats are methodical and Belichick, I believe, is one of the greatest minds in football today. Not that I'm biased! :)
Re: Any Football Predictions??
Kathy G
on 1/17/05 at 14:38 (167410)
Two of my four fantasy football teams won the superbowl due, in great part, to the points Adam Vinatieri got. I mean, most kickers don't throw touch down passes!
On to Pittsburgh! :)
Re: Any Football Predictions??
john h
on 1/17/05 at 16:13 (167416)
I dislike telling you the team I have rooted for since I saw my first NFL football game at age 12. The Bears and Chicago Cardinals were playing at Wrigley Field. I became a Cards fan immediately even though I lived on the North side which is Bear country. Since then they have moved to St Louis and now Airizona and they have not done squat. They are building a new zillion dollar dome which will open in 06. I do not think we have had a winning season since the 60's. This is getting old. Real old. I am able to watch all games with Direct TV which is great. If your team is playing in Pittsburg you will have to face one of the best defenses in the NFL. They run better than they pass with the Bus still moving it. Should be a great game. Hope it is snowing.
Re: Bummer!
on 1/17/05 at 19:53 (167428)
We'll getem' next year! I've been rootin for the Colts for 2 decades. What's another year.
Re: Any Football Predictions??
on 1/17/05 at 20:23 (167431)
The Chicago-St.Louis-Arizona Cardinals did manage to simultaneously break the hearts and arouse the ire of St.Louis Cardinal fans when they took off for Arizona, I recall, similar to the (Baltimore)Colts - Indianapolis and the Cleveland team to somewhere (I forget).... all of these football fan long-memories. I'm not a football fan- but I hear the passionate stories even after all these years..especially the Baltimore fans who, justifiably, recount the sneaky, underhanded way the Colts slinked/slunk/slank away in the night....
I hope the St. Louis baseball Cardinals never leave.
In the meantime, how about the University of Illinois men's basketball team???!!!! Go Illini!
Re: Any Football Predictions??
John H
on 1/18/05 at 09:20 (167453)
Dorothy it sounds like you have a good handle on sports history to me. The Cardinals are the oldest NFL franchise in existence. Over 100 years old now. It has been in the Bidwill family since the 30's. When Bill Bidwill Sr died which was probably in the early 60's his wife took over operations of the franchise. She died not many years later and his son Bill Bidwill Jr. has owned and operated it since. They also have a daughter who is VP of something. As owners go in the NFL they derrive most of their money from the franchise so they have always been slow to spend any money on FA's and quality players. Their business practices with players has been out of touch . Consequentially we have always had a lousy team. They left St Louis because of a conflict with the baseball Cardinals as when the Cardinals would get into post season play the football Cards could not play their regular schedule games at Bush stadium. They then foolishly went to AZ with no guarantee of a new stadium and had to play their games at Sun Devil stadium where temps can reach 130 degrees on the field and the fans burn up in the stadium on Sunday afternoon. Thus they have the lowest attendance in the NFL by far. They averaged 38,000 last year. Compare that to the Redskins who averaged over 90,000 and have an owner who is a zillionaire and is willing to spend it just like George Steinbrenner. Phoenix finally passed a bond issue to fund a new domed stadium and it will be open in 2006. It will be state of the art and a super bowl is already scheduled there. We still have this long histroy as a loser which is hard to overcome. Unfortunately i stick with my teams lose or win so I continue to ride it out.


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Doctor insights on:
Millipede Venom
What is the definition or description of: insect venom panel?
Flying insects: The insect venom panel uses venom from wasp, honey bee, yellow jacket, yellow hornets and white faced hornets. Fire ant allergens are also used if there is any indication to test. ...Read more
Can a child overgrow an allergy to an insect venom? If fire ant causes rashes, and swollen ear does it mean a child has severe allergy?
How old is ur child?: The reaction you described differs if before or after 5 years of age, please avoid exposure, keep an epinephrine pen and antihistaminic handy, check with an allergist/immunologist, might need desensitization according to clinical judgement after history and examination. Check aaaai.org or acaai.org for an allergist in your area, best wishes ...Read more
I was wondering what are constituents of scorpian venom?
One toxin is: Androctonus australis Hector Insect ToxinGet a more detailed answer ›
How does anti-venom work?
Anti-venom: Anti-venoms consist of animal immunoglobulins developed against whole venom. The process involves immunizing animals like horse, sheep, goats, or rabbits with the venom and extracting the anti-venom from the animal serum. When given to humans this anti-venoms bind to and neutralize the venom, halting further damage, but do not reverse damage already done. Should be administered as soon as possible ...Read more
What can a person do to remove venom from snake bites?
Nothing: Once a venomous snake has bitten, the venom gets into the system so quickly that no methods known can remove sufficient amounts. The only treatment is Antivenin at a medical facility! ...Read moreSee 1 more doctor answer
Can the venom from toad survive in pool and surfaces (time frame)?
No it does not: in my understanding the chemicals in the pool take care of all that and and you have to have some break in your skin even if you swallow water it will not harm you i hope that answer your question thank you for using health tap good luck ...Read more
If a child were to accidentally eat a poisonous spider would the child get sick from the venom?
Probably NOT: Kids can accidentally swallow tiny spiders while playing outdoors. The amount of venom in a tiny bug should not be a problem if swallowed and digested, or if rolled around in the mouth and spit out. A big poisonous spider biting a kid inside his mouth would be bad. If a kid chomped on a spider, it's possible that venom could be absorbed in the mouth; but in the stomach, acid should disable venom. ...Read more
How can I get bee venom out quickly?
By removing stinger: Asap there will be less of a venom load. Scrape along edge of skin w credit card to remove. Clean area w soap ; warm water. Apply ice in 10 min. Increments (10 on/10 off). Can try tylenol, (acetaminophen) Aspirin or Motrin for pain or Benadryl for swelling. Make paste of 2 parts baking soda ; 1 part water ; apply. Need tetanus shot every 10 years. Throat, airway, mouth swelling or difficulty breathing? Call 911! ...Read more
Can you tell me more about bee venom?
Bee Sting: Melittin is injected into the skin by a bee. This can cause significant sharp pain for a few minutes due to stimulation of pain receptor nerve endings in skin. There can be residual achy pain for several days with tenderness to palpation. Complications can cause longer symptoms. ...Read more
What do you advise if i spit out venom like a snake?
Snake Bites: It is no longer recommended that areas impacted by snake bites be lanced and that venom be sucked out. ...Read more


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Donate to our Amazon Conservation Research and Community Projects
The Amazon is ours to share and ours to protect. crees foundation could not do the work it does without the support of fantastic individuals and organisations from around the world. Donating to crees will help us to invest in sustainable businesses and training for local people and to understand and promote the value of the rainforest.


text: Is there a trick to getting this thing out? Or can I just drill out the little stud that keeps it in place in the column? This is a junkyard non-tilt column to replace a tilt column that's broke. I'm trying to replace the lock cylinder with a good one from the store with keys so it actually works.


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Herb-Cured Grilled Pork Roast
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Asthma Chronic Inflammatory Disorder Cells Elements Airways Involved Biology Essay
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This essay has been submitted by a student. This is not an example of the work written by our professional essay writers.
Asthma is a chronic inflammatory disorder wherein most cells and elements of the airways are involved. The chronic inflammation involves increased airway hyperresponsiveness and leads to frequent episodes of wheezing, breathlessness, chest tightness, and coughing, most notably at night or in the early morning. These episodes are usually observed be at a very large scale, however has a high non-uniformity of airflow obstruction. Hence, these episodes can be reversed either spontaneously or with treatment. In chronic airway inflammation of asthma there is high infiltration by T-lymphocytes of the T-helper (Th) type 2 phenotype, eosinophils, macrophages/monocytes and mast cells in the airway walls. Also, during exacerbations, there is acute inflammation with a sudden increase in eosinophils and neutrophils infiltration.
Inflammatory processes associated with asthma include airway infiltration with inflammatory cells of the immune system, airway epithelial wall disruption, subepithelial deposition of matrix proteins like collagen, fibronectin, tenascin and other elements, hypertrophy and hyperplasia of airway smooth muscle increase in vasculature of airway, and increase in goblet cells and other mucus secreting cells and eventual hyper-secretion of mucus in the airways. The inflammatory cells include T-lymphocytes, mast cells, and eosinophils. These inflammatory processes are caused mainly by T-helper type 2 (TH2) lymphocytes. The TH2 cells secrete cytokines and chemokines that in turn lead to activation and recruitment of eosinophils (interleukin [IL]-3, IL-5, granulocyte/macrophage colony-stimulating factor) and mast cells (IL-9, IL-4), and permit inflammatory cell influx into the airways. Asthma is partly a consequence of imbalance in TH2 lymphocytes rather than T-helper type 1 (TH1) lymphocytes which is responsible for delayed hypersensitivity reactions.
In recent past, the treatment of asthma has mainly included alleviating the symptoms rather than curing the disease. Pulmonary route of delivery of drugs has been the mainstay of treatment mode in the past for temporary relief of exacerbations in asthma. The most popular drugs used include β2 adrenergic receptor agonists, such as salbutamol sulphate, formoterol fumarate and salmeterol xinafoate. These are recently been administered along with a 2nd class of drugs called corticosteroids, and also other drugs. The table 1 presents a list of the most widely used β2 adrenoceptor agonist drugs in asthma treatment.
Onset of Action
Duration of action
Salbutamol (Albuterol)
Table 1: Onset and duration of action of inhaled β2 agonists.
Drugs used in the treatment of asthma
Anti-inflammatory drugs are by far the most important class of drugs for asthma treatment. These are mainly glucocorticoids and theophylline. However, most formulations in dry powder inhalers (DPIs) and pressurized metered dose inhalers (pMDIs) make use of short or long-acting β2-adrenoceptor agonists. Table-2 summarizes studies on the efficacy of the drugs in control of asthma, particularly with reduction in inflammatory cells of immune system.
Asthma Drugs
Control of Asthma
Inhaled corticosteroids
Sodium cromoglycate
Sodium nedocromil
Short acting β2 agonists
Long acting β2 agonists
Leukotriene Synthesis Inhibitors
CysLTs receptors antagonists
Furosemide + salycilic acid
Table 2: Bronchial anti-inflammatory activity of asthma drugs. + effective, - not effective, +/- controversial effect, ? no data available, Biopsy= reduction in bronchial inflammatory cell number with chronic treatment.
Each class of drug has a different mode of action and contributes to lessening the symptoms of asthma via different mechanisms. Consequently, depending upon the physicochemical properties of the drugs, they need to be formulated in different ways. The most widely used routes of administration of anti-asthmatic drugs are oral route via the gastro intestinal tract and the pulmonary route, which is a more direct route of transporting the drugs to their site of action. The next section summarizes the different classes of drugs, the drugs in market that fall in these classes, the different formulations available in the market and the mechanisms by which these classes of drugs act to perform their anti-inflammatory and bronchodilatory actions on smooth muscles in the respiratory tract.
Review of the Important Classes of Drugs used in Dry powder Inhalers and Other Formulations for Asthma Treatment :
Class 1. Short Acting β2-adrenoceptor agonist (Salbutamol, Terbutaline):
Salbutamol (Albuterol) Sulphate, a moderately selective β2-adrenoceptor agonist, is a racemic mixture of R- and S-isomers. Salbutamol Sulphate is widely used as a bronchodilator and is indicated for the management of asthma exacerbations or other chronic obstructive airway diseases. Salbutamol Sulphate is similar in structure to terbutaline, but exhibits less cardiac stimulation and more prolonged bronchodilation than isoproterenol or metaproterenol. It is a short-acting β2 agonist and considered as first line therapy for mild intermittent asthma during pregnancy (according to the 2004 guidelines of the National Asthma Education and Prevention Program (NAEPP) Asthma and Pregnancy Working Group).
Salbutamol (Albuterol) Sulphate's innovator is Boehringer Ingelheim-Global and appears world-wide under the brand names Combivent and Duoneb.
Salbutamol Sulphate stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle. Salbutamol Sulphate is racemic beta-agonist, comprised of an equal mixture of R- and S-isomers. The R-isomer, known as levalbuterol Sulphate, is primarily responsible for bronchodilation.
Intracellularly, the actions of Salbutamol Sulphate are mediated by cyclic AMP, the production of which is augmented by β2-stimulation. Salbutamol Sulphate is believed to work by activating adenylate cyclase, the enzyme responsible for generating cyclic AMP, an intracellular mediator. Increased cyclic AMP leads to activation of protein kinase A, which inhibits phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in relaxation. The net result of β2-receptor agonism in the lungs is relaxation of bronchial and tracheal smooth muscles, which in turn relieves bronchospasm, reduces airway resistance, facilitates mucous drainage, and increases vital capacity.
Salbutamol Sulphate can also inhibit the degranulation and subsequent release of inflammatory autocoids from mast cells. Stimulation of β2-receptors on peripheral vascular smooth muscle can cause vasodilation and a modest decrease in diastolic blood pressure. Salbutamol Sulphate is an effective adjunctive treatment for hyperkalemia; β2-adrenergic stimulation results in intracellular accumulation of serum potassium due to stimulation of the Na/K ATPase pump, leading to moderate degrees of hypokalemia.
Class 2. Long Acting β2-adrenoceptor agonist (Formoterol, Salmeterol) :
Long acting β2-adrenoceptor agonists (LABAs) relax bronchial smooth muscle and thereby elicit bronchodilation in patients with asthma. Recommended for use in combination with inhaled corticosteroids, they provide additional benefits to those patients inadequately controlled with corticosteroids alone and may ultimately permit tapering of the dose of inhaled steroid. The drugs included in this class are Formoterol and salmeterol. Formoterol has a rapid onset of action (1-3 minutes), which is comparable with that of short-acting β2-agonists (e.g. salbutamol and terbutaline), and a mean duration of action of 12 hours following inhalation of a single dose. Thus patients can experience prolonged bronchodilation with formoterol. Risk associated with use of formoterol includeprolongation of QTc interval, paradoxical bronchospasm and hypokalaemia. Salmeterol, on the other hand has a slow onset of action, but its effect on bronchodilation lasts upto 12 hours. This permits twice-daily dosing and enables good control of nocturnal asthma.
Class 3. Inhaled Corticosteroids (Beclometasone, Budenoside, Ciclesonide, Fluticasone, Mometasone) :
This is the most potent class of drugs for the treatment of asthma. In most asthmatic patients adequate doses of inhaled glucocorticoids, particularly if combined with long-acting bronchodilators, allow systemic glucocorticoids to be reduced or withdrawn completely. Glucocorticoids consistently lessen airway hyperesponsiveness in asthma. Indeed, long-term treatment with glucocorticoids reduced airway responsiveness to histamine, cholinergic agonists, allergens (affecting both early and late responses), exercise, fog, cold air, bradykinin, adenosine, and irritants such as sulfur dioxide and metabisulfites. Treatment benefits include not only reduced sensitivity of airways to spasmogens, but also limiting of maximal narrowing of the airway in response to a spasmogen. The reduction in airway hyperesponsiveness may not be maximal until treatment has been given for several months. The magnitude of the reduction varies, and airway responsiveness can remain abnormal. When therapy is discontinued airway responsiveness usually returns to pretreatment levels.
Fig: The mechanism of glucocorticoid action.
Fig: Cross-talk between glucocorticoids and long acting b2-agonists.
Class 4. Leukotriene Inhibitors (Montelukast, Zafirlukast, Zileuton) :
Leukotriene inhibitors are the first new class of medications for the treatment of persistent asthma that have been approved by the U.S. Food and Drug Administration in more than two decades. Leukotrienes are synthesized in response to many triggers, including receptor activation, antigen-antibody interaction, physical stimuli such as cold, and any stimulation that increases intercellular calcium. These potent inflammatory mediators promote neutrophil-endothelial interactions, inducing bronchoconstriction and enhancing airway hyperresponsiveness. They also stimulate smooth muscle hypertrophy, mucus hypersecretion, and the influx of eosinophils into airway tissues. Therefore, inhibition of leukotrienes potentially plays an important role in the treatment of asthma and other allergic conditions such as allergic rhinitis, atopic dermatitis, and chronic urticaria.
Leukotriene inhibitors are either leukotriene receptor antagonists or leukotriene synthesis inhibitors. Leukotriene receptor antagonists selectively block cysteinyl leukotriene (cysLT1) receptor, whereas leukotriene synthesis inhibitors block 5-lipoxygenase activity. These inhibit both bronchoconstrictive and inflammatory effects of the leukotrienes, which are inflammatory mediators associated with asthma pathophysiology. Montelukast has a rapid onset of action, minimal side effect profile and is administered orally. Thus it is easily formulated and bears no complications of inhaler devices.
Class 5. Anticholinergics :
Class 6. Theophylline :
Effect of Combination of classes (Corticosteroids and β2-adrenoceptor agonists) used in pMDI and DPI formulations in Asthma treatment :
In recent times there have been several formulations that include a combination of drugs of different classes, owing to their complementary modes of action.Fluticasone, for example, increases the responsiveness and number of β2-adrenoceptors, and therefor has the potential to elevate the efficacy of salmeterol. It is proposed in various studies that salmeterol enhances the ability of fluticasone to induce apoptosis in eosinophils by 3-5 folds. It is also reported that long acting β2-adrenoceptor agonists may prime the corticosteroid receptor for ligand binding and, enhance the translocation of the corticosteroid-receptor complex to the nucleus. However, the data available in support of this is not sufficient and additional studies are required to demonstrate that salmeterol exerts any meaningful anti-inflammatory activity in-vivo.
Figure 2. In vitro evidence suggests that ß2-agonists may prime inactive corticosteroid receptors (2A) and that corticosteroids may increase the number of ß2-receptors and their sensitivity to ß2-agonists (2B). Primed receptors are activated more easily by corticosteroids, and less steroid is required to convert the primed receptor to an active receptor. This priming effect could explain why a lower dosage of an inhaled corticosteroid plus a long-acting ß2-agonist is more effective than a higher dosage of an inhaled corticosteroid alone.
Salbutamol Sulphate
Salbutamol Sulphate is a short-acting β2 adrenoceptor agonist. The form of the drug used in formulating medicines is a racemic mixture of R- and S-isomers. The R-isomer, known as levalbuterol Sulphate, is primarily responsible for bronchodilation. Salbutamol Sulphate has been widely used owing to its ability to act as a bronchodilator and give immediate relief in cases of asthma exacerbations or other chronic obstructive airway diseases. Salbutamol Sulphate has a similar structure to terbutaline, but is more effective in the ability to bronchodilate for longer period of time than terbutaline. It is also the main drug for treatment in mild asthma in conditions of pregnancy in females (according to the 2004 guidelines of the National Asthma Education and Prevention Program (NAEPP) Asthma and Pregnancy Working Group).
Salbutamol Sulphate's innovator is Boehringer Ingelheim-Global and their products with Salbutamol sulphate appear in the world market under the brand names Combivent and Duoneb.
Intracellularly, the actions of Salbutamol Sulphate are mediated by cyclic AMP, the production of which is augmented by β2-stimulation. Salbutamol Sulphate works to relax the smooth muscles and bronchodilate the airway walls via the following mechanism: It activates adenylate cyclase which is the enzyme responsible for generating cyclic AMP, an intracellular mediator. Elevated levels of cyclic AMP causes an activation of protein kinase A (PKA). PKA inhibits phosphorylation of smooth muscle protein, myosin and the intracellular calcium ion concentration drops. This is the event that leads to smooth muscle relaxation in the bronchi and trachea, alleviates bronchospasm, permits freeflow of air through the airways, decreases mucous concentration by effective drainage and subsequently improves vital capacity.
Another mechanism by which Salbutamol Sulphate lowers bronchial hyper reactivity (BHR) and airway inflammation is by inhibition of degranulation and subsequent release of inflammatory autocoids from mast cells.
Delivery devices (Martin J Telko et.al. RESPIRATORY CARE •€ SEPTEMBER 2005 VOL 50 NO 9)
Inhalation drug delivery systems can be divided into 3 principal categories: pressurized metered-dose inhalers (pMDIs), DPIs, and nebulizers.
Nebulizers : Nebulizers are distinctly different from both pMDIs and DPIs. Nebulizers incorporate dissolved or suspended drug in a polar solvent, mainly water. The aerosol is continuously delivered over extended period of time and is useful in case of severe asthma for continuous exposure of airways to drug. Nebulizers are used mostly in emergency cases and in hospitals, and due to their bulky size and inconvenience to carry around, they are not generally used for chronic-disease management.
pMDI : pMDI is by far the most widely used device owing to its convenience in handling and ease of administration of dose. Because a pMDI is pressurized, it emits the dose at high velocity, leading to deposition in the oropharyngeal region and the lower airways devoid of the dose. Thus, pMDIs require careful coordination of actuation and inhalation. There are several enhancements to the pMDI design such as the use of spacers for children. Problems reported with use of pMDI include improper administration leading to wrong dose, and the propellant like CFC and cosolvents, may extract organic compounds from the device components.
DPIs : DPIs are drug delivery devices for pulmonary drug delivery that contain solid drug particles in the DPI device that is fluidized when the patient inhales. The development of DPIs has come about after there were several disadvantages with the use of pMDIs reported, such as emission of ozone-depleting and greenhouse gases (chlorofluorocarbons and hydrofluoroalkanes, respectively) that are used as propellants, and inability to deliver macromolecules and products of biotechnology. DPIs are easier to use, more stable and efficient systems. DPIs are activated by the patient's inspiratory airflow, hence they do not require propellent nor do they need to have coordination between actuation and inhalation. The resultant in better lung delivery than with pMDIs. Since DPIs are typically formulated as one-phase, solid particle blends, they are also preferred from a stability and processing standpoint. Also, due to lower energy state of the powder formulation, there is reduction in the rate of chemical degradation and reaction with contact surfaces.
Table 1. Summary of the features of Dry Powder Inhalers in comparison with Metered-Dose Inhalers:
Advantages of the Dry Powder Inhaler
Disadvantages of the Dry Powder Inhaler
Environmental sustainability, propellant-free design
Deposition efficiency dependent on patient's inspiratory airflow
Little or no patient coordination required
Potential for dose uniformity problems
Formulation stability
Development and manufacture more complex/expensive
Principle of operation :
Fig. 1. Principle of dry powder inhaler design.
The formulation typically consists of micronized drug blended with larger carrier particles, dispensed by a metering system. An active or passive dispersion system entrains the particles into the patient's airways, where drug particles separate from the carrier particles and are carried into the lung.
Most DPIs employ drug powder in the inhalation range, i.e. between 0.5-5µm diameter. This drug is blended with larger carrier particles such as lactose of typically 60µm size. Carrier particles like lactose help prevent agglomeration of the API powder and improves the flowability of the DPI formulation. The dry powder aerosols are generated when the powder in static powder bed is moved and dispersed in the stream of air. Movement can be brought about by several mechanisms. The most notable of these is based on the patient's inspiratory flow. The patient activated the DPI and from the mouth of the device, the patient inhales. This causes airflow in the device with turbulence and shear. The air fluidizes the powder in the static bed and the powder is dispersed. It enters the patient's respiratory tract along with the inhaled. The carrier particles being large and bulky, get trapped in the oropharynx and are cleared, whereas the drug particles attached to the carriers, owing to their small size and the force of airflow, get detached from the carriers and enter the lower airways. Thus deposition in the lungs is determined by the patients' inspiratory flow rate and is variable from patient to patient, although the device and formulation are the same. One of the major problems with the use of DPI, observed commonly with currently available DPI formulations is the inappropriate adhesion forces between drug and carrier particles. With adhesive forces lower than optimum, the drug gets detached very soon and does not enter the patient's respiratory airways; whereas with adhesive forces higher than optimum, the drug is not released optimally, and gets deposited in oropharynx along with the carrier. 24-26 Inadequate drug/carrier separation is one of the main explanations for the low deposition efficiency encountered with DPIs.27
Also, dose uniformity is a challenge in the performance of DPIs as this varies with patients' inspiratory airflow. To overcome the problem of dose uniformity, various studies on dispersion mechanisms are currently being done globally. Some of these include several power-assisted devices like pneumatic, impact force, and vibratory.
Powder properties can vary widely. Powder features, such as the physicochemical properties and morphology of its constituent particles and the distribution of particle sizes, contribute to variability. The required properties of the powder particles are :
Less cohesive and adhesive particles through corrugated surfaces,
low bulk density,
reduced surface energy and particle interaction to facilitate deaggregation
reducing aerodynamic diameters through particle engineering
To achieve these, incorporation into carriers
Unlike liquid solutions or gas mixtures, powders are never completely homogeneous (at primary particulate scale) and segregation by size, which is a function of external forces, is always a potential problem. The aerodynamic behavior, which has a profound effect on the disposition of drug from a DPI, is particularly sensitive to powder properties.
The different factors important in formulation of dry powders for inhalation include :
Crystallinity and Polymorphism
Moisture Content and Hygroscopicity
Particle Size
Aerodynamic Diameter and Dynamic Shape Factor
Fine-Particle Fraction
Surface Area and Morphology
Crystallinity and Polymorphism :
Nearly one third of all drugs are known to display polymorphism, 40 which is the ability of a solid to exist in more than one crystal from. A prominent example of a polymorphic pharmaceutical is carbamazepine, which has 4 known polymorphs. Different polymorphs are at different energy states and thus have different properties, including stability, solubility, and even bioavailability.
It is also possible to generate a noncrystalline solid. In most cases this involves cooling a fluid so rapidly that its
molecules lose mobility before assuming their lattice positions. A noncrystalline material is considered amorphous because it lacks long-range order. Amorphous materials have higher Gibbs free energies than crystals; thermodynamic laws predict that, in the long-term, materials seek to minimize their free energies by transitioning to lower energy states (eg, crystallization). Whether this will occur at a timescale that need be of concern to the pharmaceutical scientist is governed by the chemical kinetics of the system. Polymorphs usually differ in density, melting point, solubility, and hygroscopicity. The most stable polymorph frequently has the highest density, highest melting point, and lowest solubility. Discriminating analytical methods to characterize polymorphs include x-ray diffraction and thermal analysis, such as differential scanning calorimetry.
Current commercial Salbutamol formulations
Salbutamol 100mcg + Beclomethasone 50mcg
Aerocort Hfa
Salbutamol 100mcg + Beclomethasone 50mcg
Ecopack Inhaler
Salbutamol 100mcg + Beclomethasone 50mcg
Salbutamol 100mcg + Ipratropium 20mcg
Salbutamol 100mcg + Sodium Cromoglycate 1mg
Salbutamol 2.5mg + Ipratropium 500mcg Per 2.5ml
Salbutamol 2.5mg + Ipratropium 500mcg Per Ml
Respirator Soln
Salbutamol 200mcg + Beclomethasone 100mcg
Salbutamol 200mcg + Ipratropium 40mcg
Salbutamol 400mcg + Beclomethasone 200mcg
Aerocort Forte
Salbutamol 100mcg
Ecopack Inhaler
Asthalin Hfa
Salbutamol 100mcg
Ecopack Inhaler
Salbutamol 100mcg
Ecopack Inhaler
Salbutamol + Ambroxol Hcl
Axalin - Ax
Salbutamol 100mcg
Salbutamol 2.5mg Per 2.5ml
Salbutamol 200mcg
Salbutamol 2mg
Salbutamol 2mg Per 5ml
Salbutamol 4mg
Salbutamol 4mg Sa
Asthalin Sa-4
Salbutamol 5mg Per Ml
Resp Solution
Salbutamol 8mg Sa
Asthalin Sa-8
Principles of Techniques used for Preparation and characterization of the formulations
The microfluidizer model used for the study was M-110S. It has an air driven pump that supplies air at the desired pressure to the product stream. As the pump strokes to and fro and completes 1 cycle, the product gets forced through the precisely defined fixed geometry microchannels within the interaction chamber. The product passes through the chamber with high velocity and creates very high shear rates. Owing to the geometry of the microchannels in the interaction chamber, the force exerted on the product is uniform throughout. This produces unique results such as uniform particles with size reduction (often submicron). For these studies, there was no use of cooling coil and bath to keep the sample in chamber at low temperature. This caused heating and subsequent agglomeration, that needed post-micronized cooling and sonication.
The specifications of the instrument are as follows :
Particle Size Distribution
Laser diffraction particle size analysis is based on the principle that all particles scatter light at a range of angles which are characteristic of their size. Larger particles scatter light at a low angle of diffraction and vice versa for small particles. The Mastersizer Microplus uses a He-Ne laser as a light source, which illuminates the particle in the measuring zone. This is then focussed by a Fourier lens to a detector which consists of a large number of photosensitive elements radiating outward from the centre. This collects the scattered light from an ensemble of particles and overlays the common angles of scattering on the detector array. The intensity of the scattered light is measured and using an optical model (Mie theory) to calculate the scattering pattern and a mathematical deconvolution procedure, a volumetric particle size distribution is calculated that best matches the measured pattern.
In order to convert the scattering pattern obtained from these particles to an actual particle size distribution, the Malvern software makes use of a "Presentation", which is a predicted scattering pattern from theoretical particles. The Presentation takes into account specific information about the particles and the material that they are suspended in, such as the relative refractive index of the particles, the absorption properties of the particles (known as the imaginary refractive index) and the refractive index of the dispersant, so that it can calculate exactly how light passes through them. Use of correct Presentation is importantfor smaller particles (below 10 microns), and also when the refractive indices of particles and dispersant are close. The refractive indices of Salbutamol sulphate and Isooctane are 1.553 and 1.3915 respectively.
Spray Dryer
The spray drying process consists of 5 stages : (1) Atomisation of feed into spray of droplets, (2) spray-air contact and droplet/particle flow, (3) evaporation of solvent, (4) separation of particles from drying air, and (5) dried product handling for further use.
Atomisation transforms the liquid feed entering the spray-drying nozzle into a droplet cloud that once contacted with hot drying air provides optimum conditions for solvent evaporation. Liquid feed and atomising gas (typically compressed air or inert gas like nitrogen) are passed through the nozzle simultaneously. The high air velocity generated in the nozzle then breaks up the liquid into a spray of fine droplets, which can produce fine powders of <10 microns in size. Spray-air contact results in rapid evaporation with short drying times. Heat transfer to the particle is by convection from air to the drying droplets and a saturated vapour film rapidly develops at the droplet surface where evaporation of volatile solvent takes place. Solvent diffusion to the surface maintains saturated conditions at the surface, and evaporation takes place at a constant rate - primary drying. When the volatile content becomes too low to maintain surface saturation, the critical point is reached and a dried layer of material forms at the surface. Further evaporation of solvent is now dependent upon diffusion through this surface layer - secondary drying, and the thickness of the layer increases with time until a solid particle is formed. During evaporation, thebspray distribution undergoes a variety of size and shape changes, and the resultant particle distribution shows a degree of polydispersity. Particles are separated from the drying air by means of cyclones. These separations are critical for maximizing the product yield and previous studies have shown upto 90% yield for inhalation powders. The circulation of air within cyclone produces a centrifugal force on entrained spray dried particles. The consequence is radially outwards and downward movement of particles before impacting on the walls of the cyclone or collection bottle. The powder is physically removed by scraping the vessel walls.
X-Ray Diffraction
XRPD was used to determine the crystallinity of the spray dried powder sample, i.e. amorphous, partially amorphous or crystalline. In XRPD, the generated X-rays are collimated and directed onto the sample, where part of the beam is absorbed, refracted, scattered, and most importantly, diffracted. The diffraction distance between the d-spacings (planes of atoms) is measured using Bragg's law :
nλ = 2d.sinθ
where, n=order of diffracted beam, d=distance between adjacent planes of atoms, λ=wavelength of incident X-ray beam, θ= angle of incidence of X-ray beam.
The characteristic set of d-spacings generated in an X-ray scan gives a unique fingerprint of the material. The crystalline form is characterized by number of sharp and narrow peaks within the XRPD pattern. The amorphous materials, owing to their lack of long-range order of packaging of molecules, do not give peaks. Amorphous material is generated in spray drying, as rapid evaporation of solvent inhibits the molecules to align in crystal form.


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Vent Coffee Roasters
Block title
Vent Coffee Roasters
| |SaturdayFood Avenue
| |SundayFood Avenue
We are a small coffee roasting company located inside Argosy Cafe in Downtown Baltimore City. Determined to support our city, we solely use coffee importers in the Baltimore area. We are one of a few shops that offer Nitro Cold Brew and Cascara Tea (dried coffee cherry fruit) in the area. We look forward to serving you so stop by for iced lattes, cold brew iced coffee, cascara soda, and more!


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> Grow Your Own
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It's now easy to grow your own vegetables with this set of 3 Haxnicks Vegetable Patio Planters. They come in different sizes and are specially desi...more
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text: Stayed in Noosaville 22nd to 25th October and passed Grenny's Restaurant and like most traveller noted how many used this premises. Like most Cafe/Restaurants in this area they have Lunch and Dinner specials so we choose to have a Three Course Dinner special. The cost for the Quality of service and food was excellent and cannot fault this lovely friendly... More


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Neil Diamond Tribute Band Super Diamond
* Additional fees apply. No coupon or promo codes necessary to enjoy the displayed discount price.
The last date listed for Super Diamond was Friday September 26, 2014 / 9:00pm.
Currently at House of Blues Anaheim
'80s vs. '90s Dance Party With DJ Biz Markie: Decades Collide
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Danceability has always been an engine of pop music, but which decade -- the '80s or the '90s -- had… More
Venue Details
Event Website
Quotes & Highlights
Watch videos of Super Diamond on the band's website.
"Super Diamond is six guys in sequins and funny haircuts providing, with a wink or two (but no more), what they like to call 'The Alternative Neil Diamond Experience.' It's a great show, with all the required moves for a Neil Diamond tribute: a singalong 'Song Sung Blue,' an anthemic 'America,' a 'Sweet Caroline' crooned to a roomful of waving Miller Lites." -SF Weekly
"…most tribute bands languish in bar-band anonymity. But a handful, like Super Diamond, a Neil Diamond tribute band that tours nationally, have become enormously successful and have achieved pseudo-stardom in their own right." -The New York Times


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When it comes to evidence, a slip and fall legal professional looks at all perspectives of any particular scenario. It does not make a difference whether it took place last night or two months ago, a legal professional will always advise clients to go back and fill out a report about what happened. The more specifics presented, the better.
Finding the Right Person
When the accident occurs, it is important to report it right away. While mentioning to a passing bystander may accelerate help and support, it is not considered to be an official notice. A slip and trip lawyer wants to make sure that the client sat down with a representative of the company and filled out the vital documents.
This does not mean that somebody from the business office in another location or state needs to make the expedition to the site. It does mean that someone with authority to speak for the company should be addressing the incident. A slip and fall attorney at law can be present at the declaring if important.
Filling Out the Questionnaires
Some lawyers have a simple one-page data sheet that documents any experiences that take place on the residential property. If an employee is hurt on the job or a clients sustains an injury during an appointment, the same form is used. Regardless of what the company offers, injured people should take advantage of the opportunity. Make sure that all fundamental relevant information in included such as the date and the time. If possible, clarify exactly what turned out. Essentially, it is helpful to incorporate some relevant information that shows how the other group may have been obligated for what happened. The most essential thing is to make sure that all information is specific.
Maintaining Certification
Once the statement is recorded, a slip, trip, and fall personal injury attorney ascertains that the client keeps a copy of any and all forms that are filled out and signed. These data sheets will come in handy when the time comes to put together a case. Remember that even if the document was not entered until much later on, it does prove that someone was made aware of the issue. From there, a lawyer can record how the other participant handled the details and what was done to make improvements to area in question.
Phone calls, emails and any other legal documents will be kept by the personal injury lawyer lawyer to help in making evident liability on the part of the other person. Even if the lawful professional is hanging onto unique papers, it can't hurt to keep an extra hard copy at home.


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In the sixth Emily Cabot Mystery, the intrepid amateur sleuth's journey once again takes her to a world's fair—the Paris Exposition of 1900. Chicago socialite Bertha Palmer has been named the only female U. S. commissioner to the Exposition and she enlists Emily's services as her social secretary. Their visit to the House of Worth for the fitting of a couture gown is interrupted by the theft of Mrs. Palmer's famous pearl necklace.
Before that crime can be solved, several young women meet untimely deaths and a member of the Palmer's inner circle is accused of the crimes. As Emily races to clear the family name she encounters jealous society ladies, American heiresses seeking titled European husbands, and more luscious gowns and priceless jewels. Along the way, she takes refuge from the tumult at the country estate of Impressionist painter Mary Cassatt. In between her work and sleuthing, she is able to share the Art Nouveau delights of the Exposition, and the enduring pleasures of the City of Light, with her husband and their young children.
Frances McNamara grew up in Boston, where her father served as Police Commissioner for ten years. She has degrees from Mount Holyoke and Simmons Colleges and recently retired from the University of Chicago. She now divides her time between Boston and Cape Cod.


text: Concern Over Hospital Failings Prompts Urgent Review Calls Problems Identified At Dewsbury and District Hospital 05.08.2011 Medical law experts at Irwin Mitchell have joined calls for a report which recommends changes in care standards at Dewsbury and District Hospital to be published.A new publication compiled by experts has reportedly called for improvements in efforts to follow guidelines and better monitoring of heart traces during labour at the hospital, which was recently the subject of an investigation that revealed failings in the care received by a young mother whose baby died after being starved of oxygen.The inquiry was prompted by the ruling of coroner Prof Paul Marks who found that delays in inducing labour had "materially contributed" to the death of another baby at the same hospital who was less than an hour old.It has been confirmed that the Care Quality Commission is examining the findings of the latest report, but there has been no indication on when they would be made public. Now Sarah Coles, who specialises in birth injury and fatality cases and acts for a number of clients who have suffered problems at the Mid Yorkshire Trust, is calling for the findings of the report to be shared across the NHS to ensure that urgent lessons are learnt and future suffering prevented. She said: "Whilst we are yet to see the findings of the investigation it is imperative that the problems identified, and the recommendations made for changes at the hospital are addressed urgently. "It is hard enough to lose a loved one, especially a young baby, but to know that their death could have been prevented is heart breaking, and it is imperative that lessons are learnt at Dewsbury and across the NHS to ensure that no other families should have to suffer as these have going forward."This can only happen if the findings of this report are made public and the full extent of the issues is highlighted widely." Related articles 28.04.2017Lawyers Support International Workers' Memorial Day 28.04.2017Lawyers Appeal For Help On Workers' Memorial Day 28.04.2017Lawyers Call For More Awareness Of Workplace Safety On Workers' Memorial Day 28.04.2017Lawyers Call For More Awareness Of Workplace Safety On Workers' Memorial Day 28.04.2017Widow Of Carpenter Who Helped Build Sheffield's Iconic University Arts Tower Appeals For Answers After His Death From Asbestos Cancer


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I think you do fantastic work, moses.
I saw a guy on Twitter bitching that he posted a pic from Christmas of his mom with all of her sons.
He titled it Mom & Sons something very generic like that. Suddenly his pic was popping up when people searched for incest porn images.
Was that your article?
Can the Braves figure how to win in this series??
Game 1, Tues at 7:10 with Teheran vs Gsellman
Game 2, Wed at 7:10 with Dickey
Free-agent C/G Brandon Fusco (Vikings) ...
Click here for the entire article, bitches
We'll predict the series like we did last year. No individual games. 10 pts per correct answer
To make things easy, 10 pt prediction
Hopefully the Braves will be far more competitive. The addition of Kemp has improved the lineup depth.
I am OK with a catching duo of Flowers
that I'd make real fast.
Swanson to Gwinnett and bring up Albies to play SS. Swanson has now K'd 18 times in 65 ABs( for a 27.5 %.
This should be a fun series. I love that the Blues have home ice advantage. This is actually a much better matchup for us than the Wild. The PredsLast Post By: Obabikon 04-26-2017, 10:49 AM
When you draft like the Lions have the last 10 years there is not a lot of hope for this franchise.Last Post By: Suntree 04-26-2017, 05:29 AM
The Tampa Bay Buccaneers "really like" Florida State RB Dalvin Cook and will "strongly consider" ...
http://www.mlive.com/lions/index.ssf...rt_river_indexLast Post By: Suntree 04-26-2017, 04:40 AM
It is currently the bottom of the 11th.
The cardinals have played horrible baseball tonight. 4 errors. No outs with the bases loaded,
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Big Magic International (Canada)
|Big Magic International
Big Magic International logo
|November 2009
|Owned by
|Ethnic Channels Group
|Picture format
|480i (SDTV)
|Broadcast area
|Toronto, Ontario
|Formerly called
|NDTV Imagine (2009 - 2011)
Imagine Dil Se (2011-2012)
|Big Magic International
|Channel 1084
|Rogers Cable
|Channel 840
|Bell Fibe TV
|Channel 801
|Optik TV
|Channel 2320
Big Magic International is a Canadian exempt Category B Hindi language specialty channel and is owned by Ethnic Channels Group. It broadcasts programming from Big Magic, Bloomberg UTV and local Canadian content. The Channel has expanded internationally to markets like the US, Canada and Australia, which have an enormous South Asian Diaspora.
Big Magic is a general entertainment service from India, programming includes comedies, dramas, music, movies, business news and reality series.
Big Magic International was licensed by the CRTC on August 9, 2006 as Hindi TV.[1] It originally launched as NDTV Imagine In November 2009 but was subsequently re-branded as 'Imagine Dil Se' in early 2011.
On April 12, 2012, Turner Broadcasting System announced that they would be shutting down Imagine TV in India due to the channel not performing to their expectations. The channel ceased operations on May 11, 2012.[2]
On June 21, 2012, Imagine Dil Se Canada was re-branded as 'Big Magic International', following the signing of an exclusive deal with Reliance Broadcast Network.[3]
On August 13, 2015, the CRTC approved Ethnic Channels Group's request to convert Big Magic International from a licensed Category B specialty service to an exempted Cat. B third language service.[4]
See also[edit]
- ^ http://www.crtc.gc.ca/eng/archive/2006/db2006-343.htm
- ^ http://www.media247.co.uk/bizasia/turner-set-to-close-down-imagine-dil-se
- ^ RBNL launches hybrid channel for intl markets, first stop is Canada
- ^ Big Magic International Canada (formerly Hindi TV) - Revocation of licence
External links[edit]
|This article about television in Canada is a stub. You can help Wikipedia by expanding it.


text:
Fonterra has snapped up a 6% stake in Australian firm Bega Cheese, adding a fresh twist to the M&A speculation swirling around the country's dairy sector.
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- Tyson shops Sara Lee bakery, Kettle and Van's
- Nestle to cut UK confectionery jobs
- PepsiCo affirms full-year target as Q1 hits mark
- Icelandic to sell Saucy Fish Co. owner Seachill
- Tyson to buy burger-to-entree firm AdvancePierre
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To find out more about what is happening at your Library visit What's On
The Library has an event management system called SignUp that everyone can use to find activities and to make bookings using any internet enabled device.
View the calendar of Library Events and make bookings
Regular Activities for Children
Wriggle `n` Rhyme
This is a fun 30 minute session involving rhymes, action songs and music, suitable for babies and toddlers 0-2 years (but any age is welcome).
No bookings necessary.
Wriggle 'n' Rhyme is held during school terms only but finishes in Week 8 in Term 4
- 9.15am and 10am Tuesdays @ Glenelg Library
- 9.15am and 10am Thursdays and Fridays @ Brighton Library
Pre-School Storytime
This 45 minute session is suitable for pre-school children and includes stories, finger plays, rhymes/poetry, felt board stories, puppets, songs and craft.
No bookings necessary.
Pre-school Storytime is held during school terms only but finishes in Week 8 in Term 4
- 11am Tuesdays @ Glenelg Library
- 11am Thursdays @ Brighton Library
Wriggle and Rhyme Online
Enjoy Wriggle & Rhyme at any time by using this presentation.
Follow the slides and listen to the songs at home.
Click in the presentation window or use the left and right arrow keys on the keyboard to move through the slides.
You can make the presentation larger by clicking on the icon at the bottom right of the window.
Storybox Library
Enjoy storytime at any time.
Storybox Library contains a virtual reading room where Australian personalities including Missy Higgins, John Schumann, Cal Wilson, Kate Ritchie and Andy Griffiths read children's stories online.
The videos include accompanying home learning activities.
Enter your library card number again on the Story Box page.
School Holiday Activities
A range of fun activities are held during the school holidays.
For more information and to book online check What's On prior to the start of the school holidays.
Catch Us!
Would you like a visit from the Children's Programs Team?
We can bring our Wriggle'n'Rhyme singing or Storytime sessions to you!
Class Visits
Schools are encouraged to make regular bookings for classes to visit the Library. Activities may include library tours, storytelling, book talks and instruction in research methods.
Reader Advice
Our Programs Team is available to assist children, young adults and parents with advice on books, reading material and research for assignments.
Please contact us for more information or for session times and venues.
Book Discussion Groups
The Library Service supports over 20 book discussion groups. The groups generally meet on a monthly basis. Members read the same book and then come together to discuss it.
No vacancies currently exist for individuals in any of the groups.
If you are interested in forming a book discussion group, or have one already with a maximum of 8 members, please contact the Library for further information.
Download a list of titles available to book discussion groups here.
Friends of the Library
The Friends of the Holdfast Bay Library is a voluntary organisation which supports the library service by fundraising, special events and community activities.
Community members with an interest in promoting the library and its services are welcome to join.
Membership fees are paid annually at the following rates:
Membership forms are available in the library or you can download a form below.
Once completed the form and the membership fee can be lodged at either library branch.


text:
This property is briefly back on the market and will go off the market at the end of January, 2017.
This is a time-limited opportunity to own this rare Butterfly roof, featured in a Modernism Week Tour in 2016.
A renovated Butterfly-roof Mid-Century Modern with a historical designation that recognizes its authenticity with a significant tax break. Exposed beam high ceilings, an expanse of clerestory windows and sliders, it is up to date with porcelain tile floors, custom kitchen and bathroom cabinetry, Grohe fixtures, engineered-stone counter tops, all stainless steel appliances including Viking counter-top gas range, built-in gas oven and dishwasher, and stacked Whirlpool Washer and Dryer. The expansive, rear patio garden with mountain views is landscaped and designed for outdoor entertaining. The home is very private. It is located in the sixteen home MCM enclave of Tamarisk Rancho.
Information provided is for viewer's personal, non-commercial use and may not be used for any purpose other than to identify prospective properties the viewer may be interested in. All information is deemed reliable but its accuracy is not guaranteed and the viewer should independently verify all information.


text:
The Wizard of Odds answers readers' questions about Slots. $100, how much does it actually cost them? David from W. Palm Beach. It depends. If the slot play may be used in any machine in the casino, including video poker, then it can be.
How do Slot Machines Work? Slots Probability ; Offline Strategies; - One Play Strategy; - Standard Deviation Strategy; Online Strategies; - Stick a Fixed maximum.
Slot machines and video poker games only look alike. . When you bet $100 on a hand of blackjack, you lose that $100 if you lose the hand. But on an electronic slot machine game, the probability for each symbol is. ★How to make $1000 from $100 !★☆Lucky Count Slot machine☆MAX Bet (4 Bonus Features)
Free: $100 slot machines probabilities of poker
|Blindspot actress jaimie alexander boyfriend
|I should mention one other thing about Bonus Multipliers. To compute the amount the slot will retain, we divide the. The whole idea of this one play strategy is that you play the slot machine once with the highest amount possible. Las Vegas Hotels with Pools. If you never cared what the casino hold was before. The first reel is the likeliest to hit something, the second reel is less likely to hit and the third reel is even less likely 1976 Pittsburgh Pirates season hit.
|Seventy 7 lounge studio city
|1974 Atlantic hurricane season
|$100 slot machines probabilities of poker
|21 3 blackjack side bet lucky
|You replied "According to my understanding of the law, the person who pressed the spin button wins the money. Resorts with Jacuzzi in Las Vegas. This enables them to create larger jackpots and still make a profit, which makes these games more exciting ad fun. We're in the dark - sure, casinos can claim certain payback or payout percentages but how do we know they're truthful? When you hit the spin button on a slot machine game, the program stops at a number. The most famous example of this is the Wheel of Fortune slot machine game.


text:
LONDON — Whole Foods' flagship United Kingdom store, which opened here last week, offers a large assortment of Fresh & Wild Everyday Value products that are the equivalent of the "365 Everyday Value" brand in the U.S.
The company is unable to use the "365" brand because it is already registered by a competitor in the U.K., a Whole Foods official told SN. Fresh & Wild is the name of the U.K. chain of small natural food stores that Whole Foods acquired in 2004.
Other pri
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text:
February 1st, 2017
14-Year-Old Writes the Book on Beating the Odds
Nathaniel Kirera wasn't expected to survive birth. When he did, then he wasn't expected to live to see his first birthday, much less his 14th. He also wasn't supposed to be able learn, let alone write a book. But he's done all that, and today his medical odyssey is behind him.
That Nate has achieved so much despite having multicystic hydrocephalus, a condition in which half of his brain and its fluid drainage system formed abnormally, is no surprise to his mother Ann Makena, who, while she was pregnant, dreamed of a son walking and talking.
"The doctor said. 'I've seen very bad conditions, but I've never seen anything this bad,'" Ann says. "I said, 'It's not that I don't trust you … but I really felt very confident about this child. I said, 'No I'm just going to leave it up to God.'"
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Tags: Child and Adolescent Neurology, Dr Katherine Nickels, Dr Nicholas Wetjen, hydrocephalus
November 8th, 2016
Changing Minds While Learning to Live With Epilepsy
The first time Tehya Mrotek had a seizure during class, she had just begun high school. Most of the faculty and staff at Stewartville High School didn't know how to respond to Tehya's condition.
The school nurse recognized what had happened, however. The nurse explained it to Tehya when she regained consciousness from her tonic-clonic episode. But Tehya's teachers and support staff weren't very familiar with epilepsy and were not equipped to administer seizure first-aid, says Tehya's mother, Tamra Mrotek. That was six years ago.
Within three years, not only had all of Tehya's teachers and administrators become proficient in epilepsy education, but the town of Stewartville had received certification as a Seizure Smart Community from the Epilepsy Foundation of Minnesota.
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Tags: Child and Adolescent Neurology, Dr Katherine Nickels, Epilepsy


text: Stuart [h=3]Mike MacIntyre – 25th CU head football coach[/h]December 10th Introducing Mike MacIntyre From the San Jose State Spartans website, (covering only the 2009 and 2010 seasons, and*does not include the 10-2 2012 season) … MacIntyre embarks on his third season as head coach after accepting a contract extension through 2017. The 2011 Spartans produced the fourth-best positive turnaround in University football history with a 4.5 games improvement. San Jose State exhibited the resiliency and resourcefulness to find a winning way. Originally posted by CU At the Game Click here to vie


text: Comments0 (Remake) DJEND3R, The Eldritch Guardian DjRend3r March 20, 2015 User blog:DjRend3r [[File:|354px|alt=|Assassin|link=|right]]N/A – The Eldritch Guardian 7800 / 975Secondary Bar ManaRelease Date(Month) (Day), (Year)Last ChangedN/A Primary RoleSecondary RoleAssassin Fighter 100 40 10 70 Statistics Health N/A Attack damage N/A Health regen. N/A Attack speed [*] N/A Mana N/A Armor N/A Mana regen. N/A Magic resist. N/A Range 125 Move. speed N/A DJEND3R, The Eldritch Guardian is a champion concept in League of Legends. Abilities Eldritch Pactblade You are Manaless, yey... But your abilities cost an arm and a leg. Your Basic attacks pull you to your target. Additional Range 100 / 250 / 400 Sacrificial Pact RANGE: 700 COST: 15% OF CURRENT HEALTH COOLDOWN: 15 / 13 / 11 / 9 / 7 Active: Sacrificing a portion of your health to deal damage, this damage heals you for a percentage of the damage dealt. This is a straight line skillshot, stopping at the first target hit. Magic Damage: 80 / 130 / 170 / 210 / 250 (+ 70% Bonus AD) Percentage: 90% / 100% / 110% / 120% / 130% PactBlade Augmentation RANGE: 1000 COST: 20% OF CURRENT HEALTH COOLDOWN: 15 Crimson Augment: Targets who are linked Via your Pact blade have a percentage their healthregen shared with you. Percentage: 75% / 100% / 125% / 150% / 175% Active: You throw your PactBlade outwards this links to the first champion it hits, enemy or allied. Hitting Allied champions links you with them and you both gain a percentage of eachothers healthregen (doesnt stack with itself). Enemies hit with this are slowed by 40% and have damage dealt to them over 3 seconds, they are also linked for 3 seconds too, your passive is disabled while you have someone linked, linking to allied champs also disable auto attack useage but grants a 40% move speed boost to both of you, linking to enemies extends your auto attack range to the range of your linkage. (you're still melee m8 soz) Physical Damage: 30 / 50 / 70 / 90 / 110 (+ 40% Bonus AD) Implant COST: 20% OF CURRENT HEALTH Active: This can only be activated while you have an enemy linked, and therefore has no acutal cooldown. Your PactBlade no longer psychically tethers to your target anymore, and now you strike into them dealing physical damage and increasing the link duration by a further 3 seconds, however this completely disables your auto attacks, and passive effect. Physical Damage: 100 / 130 / 160 / 190 / 220 (+ 100% Bonus AD) Eviscerate Active: You rip you PactBlack out of your enemy dealing damage to them, and everything it hits on the way back to you, this breaks the linkage on your target Physical Damage: 70 / 110 / 150 / 190 / 230 (+ 110% Bonus AD) Eldritch Guardian's Awakening COST: YOUR LIFE COOLDOWN: 150 / 130 / 110 Calling apon ancient power, you sacrifice yourself to the Eldritch overlords, causing you to die after a set amount of time, this death will be considered an execute always even if you are damage, however if you are killed before its a regular kill, (but gl killing him here :P) you gain huge boosts to your AD and MoveSpeed, getting kills and assists extend the duration of this by 5 seconds. A global screech can be heard when casting this ult, and enemies within 1300 range of you are notified of your presence, (same as rengar ult but slightly different) Also the death caused by this will never put you on a deathtimer above 30 seconds. Attack Damage: 75% / 125% / 150% Movespeed: 90% / 120% / 150% Duration: 10s / 15s / 20s Retrieved from "http://leagueoflegends.wikia.com/wiki/User_blog:DjRend3r/(Remake)_DJEND3R,_The_Eldritch_Guardian?oldid=2205631" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Category: Custom champions