text:
£10.00 - On Sale
For a bit of fun the other day i decided to draw some faces on some classic spray can brands - MTN, Montana, Kobra, Ironlak etc etc
..........anyway i had a huge response from the images - PEOPLE LOVED THEM! So after being asked about 3000000 times to make them into a print....i caved and made them into a HUGE A2 print!
Each print is signed and numbered by me! So support an artist - get some fresh affordable art onto your walls and ENJOY!
Below is all the boring stuff -
594 x 420 mm / 23.4 x 16.5 in
300 GSM WHITE RECYCLED FLECK CARD 1/4 (full colour) single-sided print.
Mailed items depend on postal service - all items sent first class via Royal mail.
Please also note it may take me up to 10 days to post things as i am all over the place doing artwork and sometimes im away when an order comes in - but it will 100% be sent and it will be worth the wait ;)
POSTING TO ANOTHER COUNTRY WILL TAKE EXTRA TIME - PLEASE BE AWARE - I DO POST THE DAY OF PURCHASE (or the day after if its ordered after 4pm) MAY TAKE UP TO 4 WEEKS.


text:
Gordon Brown last night avoided a damaging rebellion by Labour MPs over a windfall tax on energy companies.
A rebel MP leading calls for suppliers to be hit with a one-off tax said that he no longer regarded it a "deal-breaker" in helping poor families to meet the cost of rising energy bills.
Union leaders gathering at the TUC conference in Brighton tomorrow will press ahead with demands for energy firms to surrender a proportion of their huge profits.
But the retreat by Rob Marris, a ministerial aide, will come as a relief to the PM after his attempted "relaunch" last week was overshadowed by more questions over his leadership. Mr Brown faced the threat of cabinet resignations if the multibillion-pound tax had gone ahead. The Chancellor, Alistair Darling, and John Hutton, Secretary of State for Business, had warned that a windfall tax would damage the economy.
Mr Marris said yesterday: "The Government has made good progress in its negotiations with the energy companies. I still favour a windfall tax but it is not a deal-breaker for me. We have got to look at the whole package."
Mr Brown will continue his fightback tomorrow when the Cabinet decamps to the West Midlands for its first meeting outside London. The package to help families with fuel bills is expected on Wednesday, depending on talks between ministers and energy firms.
Mr Brown is counting on signs of an economic recovery to restore his political fortunes. But yesterday the head of Britain's largest mortgage provider warned that the credit crunch could last for another 18 months.
Andy Hornby, chief executive of HBOS, told the BBC that house prices were not likely to rise again until 2010, while lenders waited "to give the confidence back into the system for banks to start lending again".
The fuel package, details of which will be outlined this week, will include around £1bn towards the cost of insulating the homes of the poorest families. The Independent on Sunday understands the Government is also planning a series of measures, including helping poorer people use the internet so they can switch suppliers. Officials are working with suppliers to increase the use of "smart meters", to help cut bills for the poorest customers.
The proposals emerged after a series of stormy meetings between ministers and bosses of the "Big Six" suppliers, which failed to result in a significant cash boost to the most "fuel poor" members of society.
Minutes of one meeting, obtained by the IoS, reveal a fundamental disagreement over the impact of pre-paid meters (PPMs), which ministers claimed left some customers paying up to £140 a year more than those using other payment methods.
"They [the companies] emphasised the point that a small percentage of the fuel poor were on PPMs," a summary of one meeting in January stated. "Both ministers dismissed the point." Later in the meeting, the energy minister Malcolm Wicks raised concerns about the ability of poorer people to switch suppliers to get the best deal. "MW highlighted the difficulties of those who aren't computer literate," the minutes say.
A source at the Department for Business, Enterprise and Regulatory Reform said the energy firms had agreed to make it easier for customers to switch suppliers over the telephone and by other means.
Critics last night warned that £1bn on energy-efficiency measures was far short of what is needed to eradicate fuel poverty. Research by the Association for the Conservation of Energy found that it would take £9.2bn to make the homes of the poorest families in England energy efficient.
Tony Woodley, joint general secretary of Unite, warned that the poor and elderly would be "lagging their coffins" rather than their roofs if the Government did not force energy companies to do more.
The Liberal Democrat Treasury spokesman Lord Oakeshott said: "This pathetic gesture by the fuel fat cats won't warm poor families' hearts. It's like striking a match in a blizzard."
Caroline Lucas, newly elected leader of the Green Party, told her party conference yesterday: "Just three companies – BP, Centrica and Shell – together made £1,000 profit every second over the first six months of this year. These corporations are robbing from the poor to give to the rich and they know it. And it's about time they learned... there is no place for robber barons."
Compounding concerns about an apparently widening gulf between the rich and the rest of society in the UK, a report – Do the Super Rich Matter? – published by the TUC today warns that the "super-rich" are wealthier now than they were at the end of the 19th century.
Union leaders will call for those earning more than £100,000 a year to pay a minimum tax rate of 32 per cent, rising to 40 per cent for those on £200,000 or more.
TUC General Secretary Brendan Barber said: "The super-rich have not created much in the way of extra wealth – they have mostly taken it from the rest of us. It's Robin Hood in reverse."
- More about:
- Brendan Barber
- Tax
- The Super-Rich
- Trade Unions

subset: commoncrawl


text:
Elected in U.S. Rep. Chris Smith (R-Hamilton, N.J.) is currently in his 19th two-year term in the U.S. House of Representatives, and serves residents of the.
HC 26 Published on 1 July 2016 by authority of the House of Commons House of Commons Home Affairs Committee Prostitution Third Report of Session.
A brothel or bordello is a place where people may come to engage in sexual activity with a prostitute, sometimes referred to as a sex worker. Technically, any. Sherman Skolnick - Gay Prostitution in the White House Contact us in Nevada. This is because a lewd conduct charge requires the prosecutor to prove that your conduct took place in a public area where you knew or reasonably should have known that someone who may be offended by the conduct was present. Prostitutes were sometimes prohibited from having a special lover. Claim your free business listing. The Affective Turn: Theorizing the Social.


text:
We are grateful to these businesses and
program partners for their ongoing support for skilled trades education
and training.
We believe in the ability of every person to
find success when pathways are available to them. We strive to make
skilled trades education and training accessible to residents of
the District of Columbia.
Featured in the Catalogue for Philanthropy
since 2011, as "one of the best small nonprofits serving Greater
The JOBS Coalition raises awareness of workforce
challenges and solutions in greater Washington.
latest news >>
Janifer Memorial Scholarship Fund >>
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Join us at The Hamilton to celebrate outstanding student achievement
in the Academy of Construction and Design. Read
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trainees in Electrical, Carpentry, and other trade specialties.
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skilled trades training facility at IDEA PCS in Northeast Washington.


text:
1.0 / November 26, 2015
App Information Peg Solitaire Gold
- App NamePeg Solitaire Gold
- Package Namepeg.solitaire.gold
- UpdatedNovember 26, 2015
- File Size14M
- Requires AndroidAndroid 2.3 and up
- Version1.0
- DeveloperCyborgWorks
- Installs100 - 500
- PriceFree
- CategoryBoard
- DeveloperEmail firstname.lastname@example.com, Udupi-576102, Karnataka, India
- Google Play Link
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모두의마블 for Kakao 1.9.84 APK
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Posted by ESPN.com's Matt Mosley
ARLINGTON, Texas -- The Cowboys opened their brand new stadium with a bang Sunday night -- but it's not the kind they wanted. Cowboys quarterback Tony Romo put his team in a hole with three interceptions, but it appeared he had helped bail them out by engineering a late drive. But on this night, the Cowboys left the Giants way too much time on the clock.
The Cowboys gashed the Giants on the ground, with Marion Barber and Felix Jones combining for 220 yards. But it was the Giants' young receivers -- namely Steve Smith and Mario Manningham -- who upstaged the Cowboys on opening night at the stadium.
A crowd of 105,121 -- the biggest in NFL history -- witnessed a back and forth game that came down to the final drive. Forced into a first-and-20 hole at his 15-yard line, Eli Manning calmly led his team down the field. And like they had all evening, Smith and Manningham made play after play.
The Giants played most of the game without Pro Bowl defensive end Justin Tuck, and the Cowboys noticed. They repeatedly ran behind left tackle Flozell Adams against Tuck's replacement, Dave Tollefson. It truly was a game where the last team with the ball was going to win -- and the Giants had the last crack at it.
OK, I'm racing down to visit with both teams. I'll have a full column on the game in about two hours. An amazing way to open Cowboys Stadium -- especially if you're the Giants.


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Missed doseIf you missed a pill risk of becoming pregnant increases. If you forgot to take one 'active' pill, take two pills as soon as you remember then return to your schedule. If you miss two 'active' pills in a row in first or second week of treatment, take two pills a day for two days in a row. Then return to your schedule. Use birth control test during seven days if such a 'mistake' occurred. If you miss two 'active' pills in a row during third week, or if you miss three pills in a row during any of the first three weeks, you need to start a new pack of pills as if you are a First Day starter. If you did not take three 'active' pills in a row during any of the first three weeks, start a new pack on the same day as if you are a First Day starter. If you skipped intake of two or more pills, you may not have a monthlies during this month. If you miss a period for two months in a row you might be pregnant. If you miss any reminder pills, throw the missed pills away and return to your schedule.
OverdoseNotify your doctor immediately if you suppose that took too much of this medication. Symptoms of overdose may include vaginal bleeding, nausea, vomiting.
StorageStore at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.
DisclaimerWe provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
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text: Overcoming hindrances 3 by Sister Dipankara 34,338pages on this wiki Add New Page Edit History Talk0 Share {{#ev:youtube|kwDS0Mm1pEc}} Retrieved from "http://religion.wikia.com/wiki/Overcoming_hindrances_3_by_Sister_Dipankara?oldid=142375" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Meditation


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Suite Bettie Jean Bed & Breakfast
Guthrie, OK 73044
The Suite Bettie Jean Bed & Breakfast in Guthrie is a Guthrie Retreat property housed on the second story of a...Learn More
The Suite Bettie Jean Bed & Breakfast in Guthrie is a Guthrie Retreat property housed on the second story of a...Learn More
The Cottages at Willow Pond are located in the countryside just outside of Guthrie in central Oklahoma. This property is...Learn More
Close to I-35 and less than four miles from the center of Guthrie, the Cedar Valley RV Park boasts 91 full service,...Learn More
Rosa Bella Guest Rooms will make you feel right at home with 1,100 sq feet of living space in historic downtown...Learn More
Addison Suites is located in the downtown district in Guthrie. Guests will find all the modern conveniences of home...Learn More
Comfortable rooms with cable TV and telephones. First floor rooms include microwaves and mini fridges. Iron/board...Learn More
Located in downtown Guthrie in the historic Sneed-Coffin building, Jaded Getaway offers three modern suites with...Learn More
Pembroke Cottage is a charming bed and breakfast located in a quiet wooded neighborhood in historic Guthrie. Built in...Learn More
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Peace, Comfort, Beautiful Beach, Magic & Wi-Fi!(70 Reviews)
The owner has been emailed.
To book this property, you need to complete your booking through checkout on the VRBO website. We can't protect your payment if we don't know you've booked through us. Learn more
- Minimum stay:1-7 nights
- Sleeps:8
- Bedrooms:3
- Bathrooms:2
- Property type:House
- Internet:Yes
- Pets considered:Yes
- Wheel chair accessible:N/A
About the Property
House, 3 Bedrooms + Convertible bed(s), 2 Baths, (Sleeps 8)
All the comforts of home is this tried and tested beautifully furnished beach house.
High Speed WIFI so you can keep in touch with the outside world!
Come and find out why so many of our guests return year after year. The kitchen is fully equipped, with everything you can think of. In addition we have digital cable, DVD player, picnic table, landscaping and under-house patio, children's playground on corner, and enclosed wet weather entrance.
Please read GUEST COMMENTS.
Comfortable, clean and beautifully decorated family, beach house in quiet residential neighborhood. The property is less than a two minute walk from the beach. Restaurant, lounge, and convenience store are all a minute away.
Bedroom one is equipped with a European pillow top queen bed, Bedroom two also has a European pillow top queen bed, and upstairs there is a large bedroom with a brand new twin bed and a comfy Queen; and ocean view balcony. There is a queen sleeper in the living room; modern appliances, and all the conveniences of home in the kitchen.
WE PROVIDE LINENS, feather or synthetic pillows to choose from; games for children, chairs to take to the beach . We keep our Non-Smoking home immaculate for you to enjoy. Well-behaved pets are welcome.
Topsail Island is a low-key, family island with an exquisite beach. Visit the unique Sea Turtle Hospital, the museum which shows the military history of Operation Bumblebee and the petrified shark's teeth found all over the island, rent 4-seater bicycles, take a boat-tour and see where Dawson's Creek was filmed, catch the plentiful fish, canoe through the marshlands, and best of all, swim in the ocean and relax on the clean, uncrowded, white sand beach! Sunrises and sunsets are spectacular, as is the abundance and variety of birds.
North Shore Country Club's excellent golf course is open to the public and just off the north end of the island.
There is even an old time roller rink in Topsail Beach!
Visit historic Poplar Grove Plantation nearby, Tour Wilmington and the retired US Battleship North Carolina.
Keywords: Beach House
When you're ready to book, here are some tips to keep in mind.
Paying with a credit card on VRBO protects your payment for up to $10,000 against listing fraud. We recommend completing your booking on VRBO.Learn more
Member since: 2004
Property Type
- House
House Rules
- Max. occupancy 8
- Minimum Age Limit For Renters
- Children Welcome
- Non Smoking Only
- Pets Considered
Accommodation Type
- Vacation Rental
- Guests Provide Their Own Meals
Onsite Services
- Housekeeper Included
Bedrooms: 3 Bedrooms, Sleeps 8, Beds for 8
Bedroom 3: 1 queen, 1 twin/ single
Beautiful and spacious upstairs room with ocean view balcony...moreless
- Bedroom 1: 1 queen
- Bedroom 2: 1 queen
- Convertible bed(s): 1 queen
- Queen size Beds (1) Two comfortable queen sized beds on first floor. Queen and single bed upstairs , Queen sleeper sofa in living room...moreless
Bathrooms: 2 Bathrooms
Other Amenities
- Books
- CD Player
- DVD Player
- Games
Satellite / Cable:
Digital cable with maximum channels in living room and expanded cable in two bedrooms....moreless
- Stereo
- Family
- Restaurants
Local Services & Businesses
- Groceries
Leisure Activities
- Boating
- Horseback Riding
- Miniature Golf
- Paddle Boating
- Shelling
- Shopping
- Sight Seeing
- Walking
- Wildlife Viewing
Sports & Adventure Activities
- Basketball Court
- Cycling
- Fishing
- Golf
- Jet Skiing
- Kayaking
- Pier Fishing
- Sound/Bay Fishing
- Surfing
- Swimming
- Dining
- Dining Area
- Seating for 8 people
- Air Conditioning
- Broadband Access
- Clothes Dryer:
Covered Parking:
Wet weather entrance, so no worries there. Also keeps vehicles out of the heat....moreless
- Hair Dryer
- Heating
- Internet
- Linens Provided:
- Living Room
- Parking For RV/Boat/Trailer
- Balcony
Deck / Patio:
Upper balcony with lovely ocean views and covered patio under house with picnic table...always a breeze and out of the sun!...moreless
House Cleaning
- Housekeeper Included
RatesCurrency Conversion
|Weekend Night
|Monthly *
off peak
Oct 1 - May 4, 2017
2 night min stay
mid season
May 5 - May 25, 2017
2 night min stay
May 26 - Sep 8, 2017
7 night min stay
mid season
Sep 9 - Sep 29, 2017
2 night min stay
Additional information about rental rates
- departure cleaning $95
- Refundable Damage Deposit $200
- Pet Fee $100
- Tax Rate 12.5%
Your security deposit is not cashed and will be torn up after your stay if it is not needed for anything.
Owner's cancellation policy:
50% refund for cancellations more than 30 days before check-in date.
100% refund for cancellations more than 60 days before check-in date.
Don't forget your vacation protection! Get protected now
Adding our Vacation Protection services can make sure your getaway goes smoothly, no matter what. We offer Cancellation Protection and Damage Protection so you can truly relax.
Beach, Day Spa, Go-carts, Water Park, Canoeing, Free Youth group activities for teens in summer, Roller Skating, Jet-ski lessons
Owner info
About the owner: Our family spent many summers staying in other people's homes on Topsail Island, until one year our dream came true. Now we love to share our home with others....and want you to feel at home while you are here. Welcome to Easy Street!
Why the Owner Chose Surf City, NC, USA:
We love the Island. It is quiet, residential and simple. The beaches are magnificent and the ocean is very friendly most of the time. Water temperature is in the 80s in the summer and early fall, so you can float to your heart's content!
The Unique Benefits at this House:
We are very close to the beach, a small grocery store, children's playground and even public rest room, if needed...
Contact us
Send email
- Primary: +001 9196975837
Links to more information:
Fully equipped spacious kitchen
Queen pillow top
Newly updated upstairs room with single and Queen beds
brand new carpeting!
Beautiful beach is a two minute walk. Public shower, toilets and play ground/
dining table seats 8 comfortably
Queen pillow top bedroom 2
Upstairs room with access to ocean view balcony
This listing was first published here in 2004.
Date last modified - Tuesday, April 25, 2017
Partner Offers
Enter dates to see accurate pricing
Peace of mind when checking out through VRBO
- We'll back you with our Book With Confidence GuaranteeTM
- You'll get comprehensive payment protection when checking out on our website
- We're always here for you with customer service available 24/7
Read more about our Book with Confidence GuaranteeTM
Send a Message
Contact the owner or see rate notes on this listing for additional information and fees
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Shakespeare Little Princess Tackle Box for Kids
Sale price: Clearance price: Starting at: Sale starting at: Clearance starting at: Reg. price:
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A two-judge vacation bench of the Supreme Court today declined to hear a petition filed by shareholders of the Bank of Rajasthan, who were objecting to the financial institution's merger with ICICI Bank.
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On May 23, the ICICI Bank had approved the merger of the Bank of Rajasthan through share-swap in a non-cash deal that valued BoR at about Rs 3,000 crore. Though 25 ICICI shares would be offered with every 118 shares of BoR, promoters Tayal family -- which have over 50 per cent stake -- would not get a seat on the amalgamated entity's board. The proposed merger is being opposed by BoR employees.


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At a time when many U.S. schools are failing students of color, one school stands out as an unusual success.
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Education has always been a bit of a black box. Before the uniform administration of state assessments, even teachers and schools who were doing truly astounding work were often only known to their students and their students' parents.
Kids will try anything to not start homework. And who can blame them? Starting is hard. In fact, it's the hardest part.
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Well-meaning liberal academics are attempting a magic solution to what is indeed a heartbreakingly enduring reality: Social inequality is inherited -- not biologically, but socially.
One of the most important California Senate Bills will be voted on soon as hearings continue this week.
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The debate surrounding the so-called broken education system in the U.S. has drawn input from leaders across industrial sectors, and in a conversation...
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You're almost in the TrainingTraders room
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Is this an Italian restaurant?
Does this restaurant have tables with seating?
Is this restaurant good for lunch?
Can a vegetarian person get a good meal at this restaurant?
Is this a seafood restaurant?
Is this restaurant good for breakfast?
Is this restaurant good for dinner?
Are the prices at this restaurant mid-range / moderate?
Is this restaurant good for dining on a budget?
Is this restaurant family-friendly?
Thanks for helping!
3 Days in Turin
Romantic Guide to Turin
Museum Guide for Turin
Small local runs by two young brothers and they do one of the most good (and natural) pizza in Torino. honest price.
I have tried a lot of pizzas in Italy, but this was definitely the best pizza I´ve ever eaten!!!
The quality of the cheese and tomate sauce were top!
We were there because we read The good reviews on TripAdvisor. The waiter took a lot until coming to serve us, did not speak English, but with the help of a local, we managed to get a translation of the menu.
However, what was described to us did not get its way onto our plates. The pasta sauce was nothing...
Saturday lunch not serve pasta dishes ever, You have been presented at 14:45 and we have made you sit, as regards the gnocchi sorry but they were not in the menu of the day which was exhibited at the entrance translated into English. .. that to which she refers is the dinner menu will be ... one of our sins,...
Enjoyed the gnocchi with mozzarella. Nice presentation. Focaccia was not as good. Too thin and overcooked. Will return and try the pizza next time!
We had good pizza there. The service was also good. A positive sign was that the other evenings we tried to go it was full. It means that place is well known and appreciated by the locals. My advise, make a reservation before going.
The pizza is extraordinary - very good and a lot of diverse choices. In addition it is very reasonably priced.
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.


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Rob Crudup (6'2"-280lbs, 5.2 forty) Plainsfield H.S in Plainfield, NJ is among the best offensive line prospects in the state of New Jersey. He is a player with raw ability (quickness, strength, and good feet).
Who has been contacting him?
Crudup has been fielding calls from Rutgers, Hofstra,Virginia, and Texas,
Who are his favorites?
Crudup stated that Rutgers
is his favorite. If they offer, there is a good chance he will commit. He likes
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He stated that Rutgers wants to review more film before making a decision.
Plainfield has lost to Union, beaten Eastside and loss to Ivrington in the final 7 second of the game. In his three games, he has 20 pancake blocks.


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Letrozole in Preventing Breast Cancer in Postmenopausal Women With a BRCA1 or BRCA2 Mutation
This trial is active, not recruiting.
|brca1 mutation carrier, brca2 mutation carrier, breast cancer, hereditary breast/ovarian cancer (brca1, brca2)
|letrozole, placebo
|phase 3
|Start date
|May 2008
|End date
|February 2017
|Trial size
|386 participants
|Trial identifier
RATIONALE: Letrozole may prevent breast cancer in postmenopausal women with a BRCA1 or BRCA2 mutation.
PURPOSE: This randomized phase III trial is studying letrozole to see how well it works compared with a placebo in preventing breast cancer in postmenopausal women with a BRCA1 or BRCA2 mutation.
|United States
|No locations recruiting
|Other countries
|No locations recruiting
|Avignon, France
|Institut Sainte Catherine
|no longer recruiting
|Caen, France
|Centre Regional Francois Baclesse
|no longer recruiting
|Clermont-Ferrand, France
|Centre Jean Perrin
|no longer recruiting
|Lille, France
|Centre Oscar Lambret
|no longer recruiting
|Lyon, France
|Centre Leon Berard
|no longer recruiting
|Marseille, France
|Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes
|no longer recruiting
|Montpellier, France
|Hopital Arnaud de Villeneuve
|no longer recruiting
|Nantes, France
|Centre Catherine de Sienne
|no longer recruiting
|Nice, France
|Centre Antoine Lacassagne
|no longer recruiting
|Niort, France
|Centre Hospitalier General de Niort
|no longer recruiting
|Paris, France
|Hopital Saint Michel
|no longer recruiting
|Paris, France
|Hotel Dieu de Paris
|no longer recruiting
|Paris, France
|Institut Curie Hopital
|no longer recruiting
|Poitiers, France
|CHU Poitiers
|no longer recruiting
|Reims, France
|Polyclinique De Courlancy
|no longer recruiting
|Rennes, France
|Centre Eugene Marquis
|no longer recruiting
|Rouen, France
|Centre Henri Becquerel
|no longer recruiting
|Saint Cloud, France
|Centre Rene Huguenin
|no longer recruiting
|Sainte-Etienne, France
|CHU Sainte-Etienne - Hopital Nord
|no longer recruiting
|Strasbourg, France
|Centre Paul Strauss
|no longer recruiting
|Toulouse, France
|Institut Claudius Regaud
|no longer recruiting
|Vandoeuvre-les-Nancy, France
|Centre Alexis Vautrin
|no longer recruiting
|Villejuif, France
|Institut Gustave Roussy
|no longer recruiting
Study Design
|Endpoint classification
|safety/efficacy study
|Intervention model
|parallel assignment
|double blind (subject, caregiver, investigator, outcomes assessor)
|Primary purpose
Letrozole, 1 tablet
(Placebo Comparator)
Comparator, 1 tablet
Primary Outcomes
Survival without contralateral or unilateral invasive breast cancer at 5 years (prior breast cancer)
time frame: 2017
Survival without invasive breast cancer at 5 years
time frame: 2017
Secondary Outcomes
Invasive cancer-free survival at 10 years
time frame: 2022
Breast cancer in situ-free survival at 5 and 10 years
time frame: 2022
Relapse-free (local or metastatic disease) survival in patients with history of breast cancer at 5 and 10 years
time frame: 2017 and 2022
Second cancer-free survival at 5 and 10 years
time frame: 2017 and 2022
Event- free (local relapse or metastatic, contralateral, or second cancer) survival at 5 and 10 years
time frame: 2017 and 2022
Overall survival at 5 and 10 years
time frame: 2017 and 2022
Toxicity according to CTCAE version 3.0
time frame: 2017 and 2022
Lipid tolerance or cardiovascular or bone event
time frame: 2017 and 2022
Quality of life according to MRS and SF36 questionnaires
time frame: 2017 and 2022
Eligibility Criteria
Female participants from 40 years up to 69 years old.
DISEASE CHARACTERISTICS: - Must meet the following criteria: - With or without invasive unilateral breast cancer more than 5 years ago, with no recurrence - No evidence of breast cancer by mammography or MRI within the past year - Carrier of the BRCA1/BRCA2 deleterious mutation (nonsense mutation or stop) - Refused preventive mastectomy - No prior bilateral breast cancer - No prior bilateral mastectomy - Hormone receptor status not specified PATIENT CHARACTERISTICS: Inclusion criteria: - Menopausal status as indicated by 1 of the following criteria: - Age > 60 years - Bilateral oophorectomy - Age ≤ 60 years with no hysterectomy or amenorrhea within the past 12 months - Age ≤ 60 years with prior hysterectomy or FSH > 20 IU/L - Eastern Cooperative Oncology Group (ECOG) or WHO performance status 0-1 - absolute neutrophil count (ANC) > 2,000/mm^3 - Platelet count > 100,000/mm^3 - Hemoglobin > 10 g/dL - Bilirubin normal - ALT and AST < 2.5 times upper limit of normal - Creatinine clearance ≥ 60 mL/min - Adequate cardiovascular function (e.g., no history of myocardial infarction, angina pectoris, or heart failure) - No osteoporosis by bone density scan (DEXA) within the past 2 years or prior osteoporotic fracture (femur, lumbar spine T score > -2 DS) Exclusion criteria: - Invasive cancer diagnosed in the past 5 years, except for basal cell or squamous cell skin cancer or carcinoma in situ of the cervix - Prior cerebrovascular accident - Prior cardiac ischemia - Hypersensitivity to letrozole or its excipients, especially titanium oxide - Renal or hepatocellular insufficiency, cholestasis, or cytolysis - Geographical, social, or psychological reasons that preclude medical monitoring in this study - Deprived of liberty or guardianship PRIOR CONCURRENT THERAPY: - See Disease Characteristics - At least 3 months since prior and no concurrent hormone replacement therapy (e.g., thyroid-stimulating hormone) - No prior hormonal therapy in the past year - No concurrent participation in another therapeutic study with an experimental drug
Additional Information
|Official title
|Prevention of Breast Cancer by Letrozole in Post-menopausal Women Carrying a BRCA1/BRCA2 Mutation
|OBJECTIVES: Primary - Evaluate the reduction of the incidence of invasive breast cancer in postmenopausal women with the BRCA1/BRCA2 mutation treated with letrozole. Secondary - Determine the reduction of the incidence of in situ breast cancer in these women. - Determine the recurrence rate of local or metastatic disease in women who have had breast cancer. - Determine the incidence of non-breast cancer, especially ovarian, colon, or endometrial cancer. - Assess the tolerance of this drug in terms of lipid, cardiovascular, and bone effects. - Determine the quality of life of women treated with this drug. - Identify serological markers that allow early diagnosis of hereditary predisposition for breast cancer. - Conduct pharmacogenetic analysis. - Identify biomarkers or genes involved in the occurrence of cardiovascular and rheumatologic metabolic aromatase inhibitors. - Study the phenotypic characteristics of cancers that occur during treatment with letrozole, in particular hormonal markers (estrogen and progesterone receptor) and expression profiles of resistance to therapy. OUTLINE: This is a multicenter study. Patients are stratified according to nature of mutation (BRCA1 vs BRCA2), oophorectomy in premenopausal state (yes vs no), and prior breast cancer (yes vs no). Patients are randomized to 1 of 2 treatment arms. - Arm I: Patients receive oral letrozole once daily. - Arm II: Patients receive oral placebo once daily. Treatment in both arms continues for 5 years in the absence of unacceptable toxicity or development of cancer or recurrent disease. Blood samples are collected periodically for pharmacogenetic studies and analysis of biomarkers or genes associated with hereditary predisposition for breast cancer, toxicities, and resistance to therapy. After completion of study treatment, patients are followed for 5 years.
Call for more information
|Principal Investigator
|Trial ID


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Our newest creation and latest addition to our Etsy Shop, Bedtime Sleep Masks ! These are fun and addicting to create, easy and addicting to use :) Quality 100% cotton prints are lined with a slim batting for light-blocking properties. These first sleep masks have a plush, soft backing that cushions and pampers. I will be making some with satin backing soon so buyers can have a choice. I'm using soft lingerie elastic for a comfy fit. Read the rest of this entry
More about Pirate and Princess Camps….
I survived my presentation of my Pirate and Princess Camp to the Parks and Rec. folks. Our meeting went well (whew!). The Camp proposals were presented and approved at the next council meeting (yeah !). Then I got word that I 'passed muster' personally (this included references and background check) (so officially I'm not as crazy as my kids may think).
Pirate woes; Arrrrrr~ I can't even get dressed..
Here's my morning of Pirate woes…. Woke too early with coughing; sore throat and congestion. Drank tea with lemon and honey. Went back to blessed sleep :)
Late morning, got up, took shower, got dressed for the day. Opened the front door to warmer weather than anticipated. Upstairs to rethink outfit. Changed shirt. Changed into nice pair of lightweight jeans. Jeans too long (have avoided hemming prior~). Took off jeans, cut off hem, turned up twice, sewed new hem :)
Ate light lunch in anticipation of noon meeting. I'm to present details of a week-long Summer Pirate Camp I intend to teach at the Parks and Rec. Department. I love kids, I love pirates; win-win situation :)
Cleaning up my dishes, I manage to splash the front area of my newly hemmed pants (okay, crotch actually). Arrrrrr~ Thinking it might look bad for the meeting I go upstairs to re-rethink outfit. Too cool out for a skirt, too warm for heavier jeans. Can't go naked, so resigned to use hair dryer on the worst of it. Use of hair dryer in close contact creates hot flash and red face :( Do not wish to appear for interview red-faced. or wet. or the appearance of embarrassed red face due to appearing to having just wet, if you follow.
I don't have time for Pirate woes !
Idea: Meeting is close enough to walk :)
Bad Idea: Don't wish to walk red-faced and wet through neighborhood. School holiday, kids playing outside…
New Idea: Wait a bit longer, do a few jumping jacks, drive with air conditioner on and arrive on time, mostly dry.
Wish me luck !
P.S. The photo above is not myself. Don't you just love her ? She does not look like she's got Pirate woes !
P.P.S. I invite you to visit our two Etsy shops, nothing Pirate-y at the moment, but you never know.
https://www.etsy.com/shop/OodlesOfWhimsy > Sewing Goodies, Pincushions, Crafty Fun
https://www.etsy.com/shop/OodlesOfVintage > Antique and Vintage Goodies
Blog trials and tribulations…and a Call to Crafters !
I just want to be left in peace to sew..and then to write about what I sew or to write about what I read about sewing. I like sewing. I think there are other people who also like sewing and reading about sewing. It's who we are, what we do :)
So imagine my surprise when I started blogging and receiving messages from people who don't care about sewing. They spam me with info that will "change your life" and "make your blog profitable". They offer amazing writing help with low-cost options such as the services of a proof-reader (I already have spell-check for free, Thanks). They want me to sign up with their bot-service so it will 'beef up' my readership (real people actually read this already). I'm offered tips on how to improve my writing with messages full of typos and broken English (I'm fluent in English). I get promises of time-saving apps I should be using (and spend precious time deleting the spam). Web builders push their services (our son, who builds websites, created our amazing business website).
Anytime you put yourself out in public, you open yourself up to the trials and tribulations of the public. If you are timid, this will startle and scare you. If you are a seasoned Grandma-lady, you know you must let it roll of your back and move on :) Lots of people want to tell you what you're doing wrong. They will attempt to show you/share their opinion about what you need to improve. You can try to remain your usual polite-self and spend time responding to those who 'know better' or you can ignore them and push forward, doing your own thing :)
Yes, I put spam filters in place. And no, I don't get bogged down by bots. Nor do I spend a lot of time on spam-mail and bogus comments.
I just want to say, I've met the nicest people online. Real kindred spirits. People who create awesome things with their bare hands. I'm awed and impressed. THAT'S who I respond to :) Those are the folks I connect with and enjoy. They are inspiring to me ! I love to read about what they are up to and see what sparks their creativity. I'm in awe to read about moms of young kids who carve out enough time daily/weekly to run a business while donating time to their favorite charity. You go, Girl ! I don't know how you manage it, but Kudos to you for doing it :)
So now that you've read thus far, here's my "Call to Crafters"… I know you're out there, toiling away on your projects. ~Making messes and creating crafty things. I'd love to hear from you ! I'd be honored to share some stories of crafters; what inspires you, what frustrates you, what challenges you to continue. Do you have any tips of the trade to share with others ? Do you like what you do or is it simply what helps pay bills ? How do you store your supplies ? Where do you show or sell items ? Does your family understand or are you alone in your passion ? I'd love to see some photos of your creations :) Please leave a message here or email me some info and let's schedule a time to chat ! firstname.lastname@example.com Thank you.
Our Traditional Thanksgiving Meal…
Thanksgiving has recently passed, I realize. But I thought I would take this post to share a little bit about our "traditional" Thanksgiving meal. Most families have hand-me-down recipes from previous generations that are brought out, prepared and celebrated at Thanksgiving.
DIY Sew a Memory or Keepsake Pillow Tutorial
Memory or Keepsake Pillow to Sew
Christmas is coming :) Here is a great gift to consider for a family member; a Memory or Keepsake Pillow. Both terms are for the same type of craft but come from different angles. Typically a "Memory Pillow" refers to someone or something from the past. Perhaps a family member has died. This project is a nice way to honor that person by using an article of clothing or other textile they once owned and used. Maybe you have one of Grandpa's favorite fishing shirts or Great Aunt Bessie's famous Thanksgiving Apron. It could be you want to save a section of a relative's antique wedding dress or tattered heirloom quilt.
A "Keepsake Pillow" is a usually a way to preserve something often connected to an event. Items such as a sports jersey, Scout's uniform, band jacket, beloved baby blankie or epic concert t-shirt can be used to make a pillow. It could also be a combination of pieces or graphics from several items in a patchwork design to accommodate more than one sports jersey or concert t-shirt.
The possibilities are endless. Lots of themes, patterns, designs, color-matching may be involved. Upcycle a garment or several, into a fun accent pillow !
Finger Pincushion; smallest item, biggest seller
My husband and I create literally OODLES of pincushions, selling to quilt shops across the U.S. We have our own wholesale website and work with another distributor as well. In addition, we sell them in our crafty Etsy shop (https://www.etsy.com/shop/OodlesOfWhimsy) and at the local Farmer's Market. We offer a variety of shapes and sizes in every color of the rainbow :) Without a doubt, our smallest item is definitely our biggest seller !
So what is a Finger Pincushion ? And what's the big deal about it ? Well, it's a mini pincushion that you wear on your finger or thumb while hand sewing. It's tiny and portable; doesn't take up much room so you can tuck one in your travel sewing kit, car glove box, purse or overnight bag. You can keep one stashed in your office drawer for those little emergencies like repairing a sagging hem or replacing a popped-off button. You can hem curtains while they are hanging and this little pincushion moves along with you so you aren't tempted to stick a pin or needle in a nearby chair cushion or (heaven forbid~) in your mouth. When the phone or doorbell rings, your pincushion stays safely with you keeping pets and toddlers away from pointy pins and needles while your attention is elsewhere. Read the rest of this entry
Farmer's Market update; Selling Crafts
We're tweaking some of the products for our Farmer's Market booth. We have added new crafts for selling there that are not even offered in our Etsy shop just to test the waters a bit. I don't usually put many seasonal items on Etsy because buyers often wait until the last minute to order and it's a bit hectic hoping USPS will get the item to them in time for a Holiday. Also, it's no fun to store any unsold seasonal crafts (and remember where I stored them!). But we are enjoying having a format/guinea pigs/testing grounds to introduce new items to sell :) I will include some photos of the new crafts within this post for you to peruse…
Selling at the Farmer's Market is Fun!
Ever wonder what it's like to sell at the local Farmer's Market ? Here is some basic information and a mini How-To based on our experience so far.
We've started selling at the local Farmer's Market this month, Saturdays only. We have met the nicest folks ! If you're in the area, please come visit us. The space we have is a combination of crafts and upcycled vintage from our two Etsy shops (Oodles of Whimsy, Oodles of Vintage). There are tie dye garments, quilt pillows, pincushions, silver plate key rings, dyed vintage doilies and more :)
If you mention you read about our Farmer's Market space in this Blog, we'll give you 20% your entire purchase !
Here is some information about the market and how we came to be here….
Oodles of Whimsy Etsy Shop SALE :) Now through August 31 ! Use code: PINCUSHION20
Check out the Shop Sale now ! Get 20% of anything and everything !
Oodles of Whimsy is having a whole shop sale. Shop now, use the coupon code and get 20% off your order :) Enter the code at checkout to get the discount on your entire purchase during my Etsy Shop Sale.
Code: PINCUSHION20 Code discount good through August 31, 2016.
Buy Fun and FuNky Earrings; $8 earrings are $6.40 on sale ! **Shop early for Christmas and get a discount !
There is a large variety of goodies in the shop; handcrafted earrings, necklaces, tie-dyed garments, an assortment of pincushions, Keepsake pillows and bears, crafting books and supplies, handwritten letter services and more. Click to visit the Etsy shop sale now: www.etsy.com/shop/OodlesOfWhimsy


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Added to Shopping Bag
Abercrombie & Fitch & Sweatshirt
Listed by DENISE
Size: 4 (S)
Price: $49.50
Returnable for Site
You can request a return for Tradesy Site Credit within 4 days of delivery. FREE return shipping.
If your item was misrepresented in any way, you can file a misrepresentation claim. Tradesy will investigate and you'll be eligible for a Full Refund.
Shopping Bag :
Reserved for -:--
& Sweatshirt
Shipping Included
Pay with Credit Card, PayPal, or Affirm.
2 people saved this item
This item may have been worn but has no visible signs of wear.
Vintage, thick and cozy hoodie. Like New.
*** Check out other items in my closet** I am listing new things all the time~! Thank you. :)
Style Tags:
Hoodie, ambercrombie, vintage, sweatshirt, white, logo, Abercrombie & Fitch Sweatshirts & Hoodies
Mon 5/1/17 - Thu 5/4/17 (4-7 days)
Feel free to return this item for any reason and get Tradesy Credit. Use your credit to buy something that makes you happy. Just a heads-up, purchases outside the U.S. are Final Sale.
Submit a return request within 4 days of delivery
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The four bedroomed house has been built around a frame of wild wood with ferro walls following the natural lines of the branches. All the furniture in the sitting room has been carved from a single fallen winterthorn tree and colored pebbles from the river decorate the ceilings. Nature has been brought into the house. On entering the house, the main room is open to the spectacular view and with a tinkling water feature, brings the sense of the River indoors. From this room you look out over the deck and pool to the river and mountains beyond.
The bedrooms, equipped with either king-size or twin beds under huge mosquito nets, are arranged on two floors and have their own private outdoor sitting area.
Bathtubs on the upper floor, allow bathers to completely immerse themselves in the wilderness experience. Innovative 'waterfall' showers on the upper floor echo the waterfalls of the upper river, whilst guests on the lower floor can enjoy the experience of 'rainfall' showers.


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The Movenpick Amsterdam Centre Hotel is in the city centre overlooking one of the many waterways just a few minutes from Central Station. There is also a tram stop right outside the Movenpick Hotel although many of Amsterdam's most famous sights and attractions are within walking distance.
Each of the 408 spacious guestrooms is equipped with modern fixtures and fittings and enjoys great views of the city and the river. Rooms have wi-fi internet access, satellite television and 24 hour room service.
In addition to an excellent bar and restaurant, guests staying at the Movenpick Amsterdam Centre Hotel can also make use of the 'lifestyle studio' which offers holistic treatments for the body and mind as well as a range of beauty treatments, a cardio fitness area, a traditional sauna, a bio-sauna and a relaxation room.
Distance from Airport:
10 miles - Amsterdam Schiphol
All have - bathroom/shower - WC - satellite TV - wi-fi internet access - minibar- safe - (certain amenities may be payable locally)
Transfer time:
20 minutes
Eating and Drinking:
The Movenpick Amsterdam has several exciting options for wining and dining. Breakfast is served in the Silk Road Restaurant where you can also enjoy a superb east meets west menu for lunch and dinner. In good weather there is an outdoor terrace and for drinks head for the trendy Silk Bar on the ground floor. If you prefer to stay in the comfort of your own room then 24 hour room service is available.
Swimming pools:
The hotel does not have a swimming pool.
Right choice:
Centrally positioned, the Movenpick Amsterdam Hotel is ideal for couples, friends and families in search of comfortable accommodation, with its own restaurant and bar and superb wellness facilities, from which to enjoy the lively Dutch city of Amsterdam.
Suitable for:
Friends, Families and Couples
Hotel 24 Hour Reception
Hotel A La Carte restaurant
Hotel Air Conditioning Public Areas
Hotel Bar
Hotel Couples
Hotel Families
Hotel Gym
Hotel Laundry Service
Hotel Lifts
Hotel Lounge
Hotel Luggage Storage
Hotel Luxury
Hotel Porter
Hotel Sauna
Hotel We Recommend


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E3 2016 – Trials of the Blood Dragon Announced, Out Now
It's as crazy as it sounds!
It's as crazy as it sounds!
Watch the debut trailer, learn more about the new protagonist.
Sequel all but confirmed with…sunglasses?
So much to love about this game.
Spoilers: It's not Aiden Pearce.
Primal glory!
And the follow-up: Far Rainbow Recon: Creed Watch 6
But who watches the Watch Dogs?
A long, long, time ago, in a world not so far away…
Watching fires and dogs, but not at the same time.
Fighting For Honor.
Information on Viking characters also inbound.
It takes five to Siege tango.
The need to eat. The need to stay warm. The need to survive.
Learning curve, balancing and diversity all discussed.
Giant list of tweaks!
It actually works.
DLC Runaway Train and The Dreadful Crimes are free.
And there's a special playable character, too.
That's not too bad!


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C. Label Liberty 21 High Heels
$38.46 Original Price $54.95
Savings: $16.49 (30%)
Upgrade your look with these fashionable high heels! Designed with a tie closure, this trend-right pair is essential to your collection.
- 4-in. heel
- Tie closure
- Polyurethane
- Imported
Shipping & Returns
Shipping your purchase is easy on belk.com. Depending on the destination of your package, you can expect it to arrive within 4-7 business days. Shipping Information
Returns are easy on belk.com. Easy returns
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