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Rocky Men's Core Waterproof 800-Gram Insulated Hunting Boot
Prices, promotions, styles and availability may vary by store and online.
800-gram 3M Thinsulate Ultra Insulation for warmth
Guaranteed Rocky waterproof construction stays dry
Durable, full-grain leather + 900D Nylon upper
Padded collar & tongue + EVA midsole for comfort
Durable outsole w/ traction on icy, uneven terrain
An ideal choice for hunting, hiking, or working outside, the Rocky Men's Core Waterproof 800-Gram Insulated Hunting Boot is sure to keep you comfortable and moving forward. Light and flexible cement construction maintains maneuverability in the boot, while the guaranteed Rocky Waterproof construction keeps the foot dry, and 800 grams of 3M Thinsulate Ultra Insulation keeps it warm. The upper combines full-grain leather and 900-denier nylon for ultimate strength and durability, and also features Mossy Oak camouflage. Furthermore, the raised toe bumper and rubber on the heel and toe add more resistance to cuts and abrasions. With a padded collar, padded tongue, and removable EVA midsole inside, this boot provides just as much cushioning comfort as it does strength. The hard-wearing outsole keeps you surefooted, offering exceptional stability and traction underfoot over virtually any terrain, be it uneven, rough, or icy. Height: 8". Weight: 5 lbs. Imported.


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Female Reproductive Pathology
Umbilicated tan papule Intracellular inclusion
Embryo/Anatomy: - Paired Mullerian (paramesonephric) ducts form and fuse to make tubes, uterus, upper vagina (default) - Wollfian (mesonephric) ducts regress All have same mesothelial (coelemic origin) field defect Infections: Herpes (HSV2): active vesicles (painful), latent neonatal infections (eye, rash, GI, probably die) (spotaneous abortions) Do Csection Do Tzank smear: multinucleated cells with intra-nuclear, "ground glass" inclusions MolluscumContagiosum Vaginitis: Candida: Cottage Cheese, itchy (DM, ABX, prego, IC) Trichamonas: yellow frothy, strawberry cervix Gardnerella: green fishy, clue cells Umbilicated tan papule Intracellular inclusion Pelvic Inflammatory Disease:infection beyond uterine corpus - Usually N. gonorrhea/Chlamydia low ab pain, tender to cervical manipulation (adhesions) - Complications: tuboovarian abscess, tube scarring ectopic preg., GI obstruction Clue cell: squamous cell covered in coccobacilli
VULVA Bartholin Cyst (usually gonorrhea) Rx: marsupulization
VIN: Vulvar Intraepithelial Neoplasm Risks: old, lots o warts, IC Invasive SCC of Vulva Masses on background of leukoplakia (esp ulcerated) 2 types (same for VIN 3) Non-neoplastic Epithelial Disorders Lichen Planus(purple, polygonal, pruritic, patches) Reticular=Wickham's striae Lichen Sclerosis (LS&A) Pruritic, painful intercourse, NOT precancerous but ass. With increased risk of SCC Thinned epidermis, sclerotic stroma (homogenized Lichen Simplex Chronicus (LSC) Thickened epidermis from chronic scratching (no atypia) Hyperplasia/keratosis, acanthosis CondylomaAcuminata(HPV 6,11) Koilocytes: raisinoid nuclei with surrounding cleared area Frequently regresses HPV (+) HPV (-) Classic VIN Simplex/Differentiated VIN Reproductive age Elderly Warty/basaloid keratinizing Verrucous Variant: no infiltration, pushing margin. Make sure you biopsy deep enough
Vulva (cont.) Vagina Developmental Abnormalities
- Congenital: imperforate hymen, double vagina - Gartner duct cyst: Wolffian derived remnant Vaginal Adenosis: mothers take DES glandular epithelium (velvety red) replaces squamous (pink) = adenosis clear cell carcinoma of vagina Vaginal Neoplasm: - 80% metastatic SCC from cervix HPV 16 VaIN Dx: cytology Prog: size and nodes EmbryonalRhabdomyosarcoma: <5yrs Grape structure from vagina/ bleeding Histo: see Z lines High rate of surgical cure Glandular Lesions of Vulva Accessory Breast Tissue: along milkline, expands during pregnancy Papillary Hidradenoma: benign from apocrine gland Extramammary Paget: pruritic, red, crusted, sharply demarcated. No underlying Carcinoma Histo: halo cells (PAS+, CEA+, EMA+, Mucin +) Malignant Melanoma: poorer prognosis b/c late presentation (S100, keratin +)
Cervix Physiology: Squamocolumnar Junction
SCJ at osEversion (Puberty) Transformation zone (post adolescent) Inversion (Menopause) transformation zone moves back up endocx canal Neoplasms: Low Grade (CIN I) High Grade ( CIN II-III) Cancer (10 years) Premalignant - CIN (cervical Intraepithelial Neoplasia) CIN I: 1/3 basal cells and atypia CIN III: full thickness (CIS) Markers: Ki-67 (cell proliferation), p16 (unregulated cyclin E) see full thickness - Culposcopy: acetowhite (dysplasia), mosaic (full thickness dysplasia) - Adenocarcinomain situ: hard to find (path same as CIN) Cancer - SCC: S&S: bleeding after coitus, advanced local invasion. Prog depends on TNM - die by invasion obstruct ureters renal failure - Rx: radical hysterectomy -Adenocarcinoma (more aggressive) Pap smear (Sensitive) + HPV DNA after 30 (Specific) = 99.5% sensitivity Inflammations: Acute/Chronic Cervicitis: -Nonspecific: loss of acidosis (bleeding, sex, douching, ABX) - Specific: STDs Endocervical Polyps - common, benign, soft/mucoid - spotting or mass of cervical os (Rx: polypectomy) Nabothian Cysts: obstructed mucous gland HPV :Vaccine is 100% at 5 yrs (HPV 6/11/16/18) Risks: young age at 1st intercourse, multiple partners, IC, BCPs, smoking Infects immature, replicates mature (therefore, without transformation zone, need microtears to access immature cells) HPV 6/11: episome (condylomas) HPV 16/18: integrated into genome E6: p E7: Rb
Uterus Proliferative Phase: Estrogen (simple tubules)
Secretory Phase: Progesterone LH Surge: Ovulation Day 14 (subnuclear vacuoles) Late Secretory: everything in lumen Menstrual: stromal breakdown, hemorrhage DUB Unscheduled bleeding (usually anovulatory) Oligomenorrhea >35 days Polymenorrhea < 24 days Menorrhagia Regular, excessive blood Metrorrhagia Irregular, excessive blood MMR Irregular menses Withdrawal bleeding Bleeding after withdrawal of hormones Prepuberty Precocious puberty Adolescence Anovulatory cycle, coagulation Reproductive age Preg. Complications, Organic lesions, Anovulatory cycle, inadequate luteal Perimeno Anovulatory, Organic lesions (BIOPSY) Postmeno Endometrial atrophy, Organic lesions (BIOPSY) Anovulatory Cycle: unopposed estrogen, no progesterone - irregular, dilated glands follicular cysts Inadequate Luteal Phase: abnormal corpus luteum = low progesterone corpus luteum cyst - Infertility with meno/amenorrhagia - Biopsy is >2 days behind clinical date Oral contraceptives: break through bleeding
Uterus (cont) Endometrial Polyps:sessile/pedunculated
S&S: bleeding, benign Rx: surgery Endometrial Hyperplasia: Disordered proliferative pattern (us. Anovulatory) - Estrogen effect therefore diffuse EIN (Endometrial Intraepithelial Neoplasia): pre-neoplasia therefore focal (atypica) Lose PTEN Endometritis Acute (np): infections from delivery/miscarriage (GAS/staph) Rx: curette Chronic (PC): Chronic PID, IUD, Tb (3rd world), retained products of conception S&S: MMR, dysmeno, pain, infertility Cancer EndometrioidAdenocarcinoma (Type I) 45-55 yo fat women -unopposed estrogen (exogenous, endogenous, PCOD, infertility, DM, HTN) - S&S: DUB surgery - direct extension, late spread to nodes/ mets 2 pathways: PTEN mutation or microsatellite instability in KRAS (HNPCC/Lynch) Endometriosis:endometrial tissue outside of uterus (us. Ovary) Adenomyosis: endometriosis in myometrium (watered silk) Adenomyoma: discrete mass of adenomyosis S&S: dysmeno, pain, infertility, scarring 2 theories: - metastatic: implant tissue - metaplasitc: same mullerian origin Tissue cycles with hormones bleeding toxic Non-endometrioidAdenocarcinoma (Type II) old skinny sick women - EIC Grade 3 aggressive early spread through lymphatics - p53 Malignant mixed mullerian tumor (MMMT): - bulky polypoid mass Chocolate cyst and powder burn
Uterus: myometrium Fallopian Tubes Leiomyoma: Benign smooth mm
Symptoms by location Bleeding: submucosal - attenuation of endometrium Pain/ sense of pelvic fullness: infarction, large mass Urinary frequency: pressure against bladder Infertility: may treat with myomectomy Miscarriage: typically 2nd trimester Salpingitis: part of PID - Usually G/C - Pyosalpinx (pus), hydrosalpinx (fluid), tuboovarian abscess - Complications: adhesions, infertility, ectopic pregnancy Paratubal cysts:Mullerianremants at fimbriated end or in broad ligament -translucent, thin-walled Ectopic Pregnancy:Usually b/c of PID/adhesions, endometriosis DDx: torsion of ovary, appendicitis Measure hCG take out, if not may lead to fatal hemorrhage Adenocarcinoma:secondary tumor (esp serous ovarian) Leiomyosarcoma: 40-60yo Mass invading uterine wall OR polypoid mass in lumen Bad tumor (mitosis, atypic, necrosis) Metastasis by blood vessel invasion Endometrial biopsy: Aspirate : Pipelle tip Cut: curette tip Scrap: loop curette
Ovaries Surface Epithelial Tumors (65-70%)
60yo women, asymp (general symp) until late (cachexia) Hereditary associations: BRCA1/2, Lynch (HNCC)- MSH2 Bilateral: serous>endometrial>mucinous No screening, CA-125 to trend, seeding of peritoneum Decreased risk by tubal ligation, BCP Serous Tumors Cystadenoma: benign, common, single layer Borderline: excrescences (seaweed), no invasion Adenocarcinoma: 65% bilateral, aggressive, poor prognosis - May present with ascites - Histo: psammoma, cribiform with central necrosis Mucinous Tumors Cystadenoma: least likely to be bilateral, most are benign Pseudomyxomaperitonei(us. Appendix): mucin in peritoneum= jelly belly Endometrioid Tumors Adenocarcinoma: may arise from endometriosis Same as endometriod Type I (PTEN, kras) can be synchronous If young: check for colon cancer (could be RAS/Lynch) Benign Cysts: Follicular Cyst: - common, simple, no LH surge Corpus Luteum Cyst: - opening from released egg seals off, may hemorrhage/torsion Endometriosis: chocolate cyst Torsion of Ovary: (us. Cystic teratoma) S&S: sudden unilateral pain DDx: ectopic pregnancy Diagnose by US Polycystic Ovary Disease (PCOD; Stein-Leventhal Syndrome)commonest endocrine of repro age women - Oligomenorrhea(chronic anovulatory) -Virulization: hirsuite, muscley, bald, large clitoris - Polycystic ovaries: >12/ovary - obese, acanthosisnigricans, DM Rule out other endocrine
Ovaries (cont) Teratomas Germ Cell Tumors Sex Cord- Stromal Tumors
Dermoid (Benign Cystic Teratoma): repro age 2-3 cell lines. See hair/keratin/teeth Rokitanski nodule on cyst wall (all 3 layers) Immature Malignant Teratoma: girls/teens Immature tissue (fetal) Rapid growth and spread Monodermal (specialized) Teratomas: mainly 1 tissue Carcinoid: (primary= bilateral, mets = unilateral) serotonin flushing, diarrhea Struma ovarii: thyroid tissue weight loss, heart palpitations Germ Cell Tumors Dysgerminoma (seminoma): Highly sensitive to radiotherapy 1/3 aggressive salpingooopherectomy fried egg appearance Endodermal sinus (yolk sac) AFP, Schiller-Duval (glomeruloid) Choriocarcinoma (gestat/non) b-HCG, aggressive, hemorrhagic Sex Cord- Stromal Tumors Granulosa-Theca Cell Tumors - yellow, make estrogen - S&S: precocious puberty, endometrial hyperplasia and CA, proliferative breast disease - Diagnosis and monitoring: inhibin - Unpredictable Fibromas: common, white, hard, rubbery ball Associated with Meig's: ascites, pleural effusion, ovarian fibroma Rx: resectfibroma Thecoma: makes estrogen, plump spindle cells with lipid droplet (stained red) Sertoli-Leydig Cell: makes androgens virulization Metastatic Carcinomas: Usually from other mullerian organs Extra-mullerian: breast, GI Krukenberk tumor:bilatmets of mucin, signet ring cancer cell, usually from GI
Placenta Causes of abortion: 1st tri: chromosomal 2nd tri: mechanical
Umbilical vein: carries oxygenated blood to fetus Umbilical arteries: carries deoxygenated blood away from fetus Amnion: baby side Chorion: maternal side (monochorion= identical twin) twin twin transfusion syndrome 3rd trimester villi: more dilated capillaries and looser stroma Causes of abortion: 1st tri: chromosomal 2nd tri: mechanical 3rd tri: fetoplacental unit Placental infection/inflammation Chorioamnionitis, villitis, funisitis 2 routes of infection 1. Ascending from vagina/cervix (acute) GBS (agalactaie), 2. Hematogenous (transplacental) (chronic) Toxoplasmosis Other Rubella CMV HSV Placentation Problems Placenta previa: implantation over cervical os S&S: painless bleeding in 3rd trimester C section or death Abruptio placenta: premature separation of placenta c lot S&S: painful bleeding Complication of preeclapmsia More dangerous for the fetus Placenta accreta: attachment of placenta directly to myometrium therefore does not separate easily bleeding Asherman's syndrome: no basalis from surgery, c sections, endometrial inflammation Hypertensive Disorders Preeclamsia: HTN, edema, protenuria HELLP: hemolysis, elevated liver, low platlets Eclampsia: pre + seizures
Gestational Trophoblastic Disease
Invasive Hydatidiform Mole - Villi invades uterine wall and can embolize to distant organs (not mets) - If uterus ruptures life threatening - Chemo (if still want kids) or Hysterectomy Too much/too big Uterus too big Hyperemesis HTN Higher in teens, 50s, Asians S&S: painless bleeding during 4th month Complete Mole Partial Mole 46XX all sperm 69XXY sperm+Egg No fetal parts FETAL PARTS!!! Villous edema with diffuse trophoblastic proliferation Few edematous villi, slight tropho proliferation ChorioCA HIGH ChorioCA low Choriocarcinoma(us. African) - From complete mole (50%) abortion (25%) normal (22%) or ectopic pregnancy - bHCG (syncytiotrophoblasts) with no villous structures - Radiosensitive - Better behaved than non-gestational ones
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"This series is everything a true fan of romance would want or need." Sinfully Sexy Book Reviews
"K. Bromberg is nothing short of an absolute genius . . . so real and raw that you truly feel every single emotion." Romance Addiction
"An irresistibly hot romance that stays with you long after you finish the book." Jennifer L. Armentrout, # 1 New York Times bestselling author"


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Top 5 Bodybuilding Movies Every Bodybuilder Should Watch
As you may already know, bodybuilding isn't just a sport or a mere hobby, it's a way of life. The diets, workouts plans, and free time are devoted to the desire to build a perfect physique. Some professional bodybuilders ultimately won Mr. Olympia titles such as Arnold, Coleman, and Ferrigno. The media has paid more attention to the industry over the years brining more awareness to the sport. In this post, we will share with you the list of documentaries and movies featuring bodybuilding. These films will inspire you regardless of who you are.
Pumping Iron (1977)
Arnold Schwarzenegger is no.1! Pumping Iron was one of earliest bodybuilding documentaries. The film both entertains and education the insanely competitive world of bodybuilding. It gives viewers a glimpse of how hard the athletes train physically and mentally and the pressure they face before and during the competition. Pumping Iron features the then full-time bodybuilder, Arnold Schwarzenegger, and the rivalry fellow, Lou Ferrigno.
Standing Tall (1997)
The film takes place in the mid 1970's when Lou Ferrigno retired from the bodybuilding world to become an actor. Lou eventually landed a famous role in The Incredible Hunk TV show. Although most believe that if he stayed in the bodybuilding world, he would be unbeatable. Standing Tall is about Lou Ferrigno's incredible journey back to competing in Mr. Olympia after nineteen years of retirement to win back his title.
Generation Iron (2013)
Similar to Pumping Iron, Generation Iron features some of the most well-known bodybuilders in the world as they train for Mr. Olympia competition. If you have seen Pumping Iron, you will notice that the sport has changed a little bit. The film is a combination of inspiration and realism. It reveals one of the toughest discipline that bodybuilders like Branch Warren and Dennis Wolf have to embrace to make it to the top.
Fittest on Earth (2016)
Fittest on Earth is one of the newest documentaries featuring the 2015 Reebox CrossFit Games. You will witness both male and female athletes compete with each other through aggressive physical challenges. "Fittest on Earth" is the title for the winner. Although, this film is not specifically for bodybuilding, it shows an aspect of the world of elite athletes.
Bigger, Stronger, Faster (2008)
In the bodybuilding world, the most negative light is shed on performance enhancing drugs, steroid. Bigger, Stronger, Faster features three bodybuilding brothers and their personal experiences with steroid. While one brother is openly against using steroid, the other two talk about how much pressure they felt to use it due to the intense pressure to win a competition. You will see an insight into the ramification each of them face as a consequence of their choices.
There are many notable elite bodybuilders who are sharing tips and techniques to build muscle mass. Our favorite is Ben Pakulski, the creator of MI40 and MI40X. If you're an aspired to gain muscle check out MI40X Review: bodybuilding workout sheets. That's it! Tell us what some of your favorite bodybuilding TV shows are movies are.


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Chat Room
We have a chat room at firstname.lastname@example.com. To join it using your browser, click here. This is the preferred way of contacting the developers. If you ask question there, stay in the room for a while. We have also our own life and we are not paying attention to the room 24 hours per day.


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Indian Boiled Rice
|Raw rice
|2 1⁄2 Cup (40 tbs)
|Boiling water
|2 Quart
|2 Tablespoon
|1⁄2 Cup (8 tbs)
1. Rinse the rice and add it a little at a time to two quarts of violently boiling salted water. Cook over high heat, stirring occasionally, until the rice is tender, ten to fifteen minutes. Drain.
2. Melt the butter in a heatproof casserole and spoon the rice over it. Cover and place over the lowest heat possible, or place in the oven. Cook ten to fifteen minutes, or until the rice is fluffy and dry. The rice may be kept hot in a slow oven for nearly an hour.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 2471 Calories from Fat 824
% Daily Value*
Total Fat 94 g144.5%
Saturated Fat 58.5 g292.6%
Trans Fat 0 g
Cholesterol 241.9 mg80.6%
Sodium 227.9 mg9.5%
Total Carbohydrates 367 g122.3%
Dietary Fiber 0 g
Sugars 0.1 g
Protein 32 g63%
Vitamin A 56.2% Vitamin C
Calcium 12.5% Iron 20.7%
*Based on a 2000 Calorie diet


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The admission policy of the school is determined by the School Governing Body, in terms of the South African Schools Act, Act 84 of 1996, and may be revised from time to time. At present it is as follows:
First time admission for Grade R learners:
Grade R learners admission age: A child must be 6 years (e.g. born November / December) or turn 6 between January and September in the year of admission.
First time admission for Grade 1 learners:
Grade 1 learners will only be admitted in the year in which they turn seven. Children who turn six before the end of June will be placed on a waiting list and will need to produce a school readiness certificate before being admitted to the school. Seven year old children will receive preference.
Placement Assessment:
Grade 1: Placement assessments will be done for all applicants to determine the entry level of the learners, thereby ensuring a fair distribution of abilities within the grade.
Other Grades: Placement assessments are needed on occasion to determine in which grade the learner must be placed.
Documentation Required (for all admissions):
- Unabridged Birth Certificate or identity document of learner
Glenstantia Primary has adopted a policy of open education, but as the medium of instruction is ENGLISH, a learner's command of the English language must be of an acceptable standard. The learner must be in a position to benefit from the education provided by the school.
A learner's education will be maximized by parent support of the school and communication between parents, educators and learners is encouraged.
Emphasis is placed on the partnership between all those involved with the education of the child. Enrolment at the school implies unconditional acceptance of the rules and criteria within this document, including the obligation to pay school fees in terms of Section 39 ' 54 of the South African Schools Act, Act 84 of 1996.


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One of the largest neighborhoods in Brooklyn, Williamsburg has undergone a major metamorphosis in the last decade.
It's transforming from a traditionally working-class neighborhood to a veritable embodiment of gentrification and urban rebirth. These days, tourists and day-trippers flock to Williamsburg for a little slice of cosmopolitan bohemia.learn more about this neighborhood
#20Neighborhood popularity:based on Naked Apartments searches
Building Mix
- 24% New Building
- 14% Walk-Up
- 12% Luxury Highrise
- 8% Pre War
- 8% Loft Building
Legal Disclosure: Neighborhood descriptions and data are created exclusively by Naked Apartments without contributions or approval from the agents listed on this page.
The Bedford Cheese Shop by 86688834@N00 is licensed under CC BY 2.0
Amazing studio with massive private deck with NYC views. The apartment features a modern kitchen with granite countertops, stainless steel appliances, and dishwasher. Striking light through out the unit. An absolute must see. Just 2 blocks from the Bedford L train!
Apartment Details
$2,700, Studio, 1.0 Bathroom
No feeExclusive
Last Updated 2 Months
Listed For 2 Months
Available Immediately
Pets: Pets Allowed
- Elevator/Laundry Building
- 475 sq. ft.
- Web ID: NKA_DreamSpace_2179
Balcony, Dishwasher, Elevator, Laundry Room, Outdoor Space, Outdoor Space, Outdoor Space, Terrace
Nearby Subway Stations
G LMetropolitan Av (0.14 mi)
G LLorimer St (0.24 mi)
LBedford Av (0.28 mi)
LGraham Av (0.49 mi)
J M ZMarcy Av (0.49 mi)
J MHewes St (0.55 mi)
GNassau Av (0.62 mi)
North 5th Street Ferry landing (0.63 mi)
GBroadway (0.7 mi)
LGrand St (0.73 mi)


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Home Concert Tickets Country and Folk Kacey Musgraves
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The trainer certification process prepares a designated credit union employee to effectively and confidently train the CUNA Creating Member Loyalty™ process. These 5-day sessions provide the content clarity, practice and one-on-one coaching designed to produce measurable results in your credit union.
To register, please select your preferred date from the list below and enter your contact information at the bottom of the form. You will receive a confirmation upon submitting the form.
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text: your probably doing this right now Click to block a category:GamingPoliticsNewsComicsAnimeOther FATasHELL next random Comment Top NextComment this is a repost next Tags: your doing this NO . I am going to study super? hard for my test tonight. I will know this stuff inside and out: by . Doing practice promblems* I actually got: t: his one right!! BREAK TIME!!!! ... +8 Views: 938 Submitted: 04/03/2011 Facebook Twitter Google+ Tumblr Pinterest


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76 Sebastopol Hill Road, Omeo VIC 3898
- Land area 1416 sqm
- Can I afford this property?
Beautiful Views of Surrounding Mountains
2 bedroom brick home, open plan living/dinning. Very comfortable easy maintenance home that also has wood heater, split system, solar hot water and powered BBQ area. There is built in wardrobes in both bedrooms and plenty of cupboard space in the laundry. Plenty of shedding with power connected set in lovely established gardens. The home is connected to mains power, phone line, town water and town sewerage system. Located walking distance from Omeo township, 40mins from Mt Hotham ski fields, this property offers terrific views of surrounding mountains and countryside. There is also an opportunity to take over lease of adjoining block of crown land (grazing licence)
- Property type: House


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A prisoner at the Calgary Remand Center is on life support today after being attacked by his cell mate on Saturday.
Emergency crews were dispatched to the Center around 9:50 Saturday morning where they found a man who had been beaten.
It's believed the attacker was the man's cellmate.
Charges are pending in the attack .


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|Reviews for Breaking the Spell
| PIKKKKKKA chapter 54 . 10/20/2014
Love this fic sooo much! Just so adorable and shippy and just yaaaaaas
| PokemonRangerFan chapter 54 . 5/30/2014
Wow, this story was truly amazing! I honestly really loved it! Thankyou!
| Random person chapter 24 . 5/28/2014
Teehee thats kind of cute!
| PokemonRangerFan chapter 9 . 5/27/2014
This was great so far but im sad they had to split up. The trio that we know and love and are inseparable, just got separated...
| PokemonRangerFan chapter 3 . 5/26/2014
Wow I didnt see that coming!
Awesome plot twist!
| fennikenfan chapter 16 . 9/15/2013
or Kate would be hit by a metal chair. That's writing for ya.
i loved that felt bad for Kate but still That's writing for ya.
| fennikenfan chapter 13 . 9/15/2013
What a beautiful day! The sun is shining, the wind is calm, the air is pleasant…..LETS SPEND IT PLAYING VIDEO GAMES AND WATCHING CARTOONS!
i do that ALL the time
| fennikenfan chapter 8 . 9/15/2013
*gives chocolate* for rhythmi hinting and being hilarious
pfft! the hair i can only imagine!
| fennikenfan chapter 7 . 9/15/2013
*gives electronic ice cream* for a great story
| Redest Crimson chapter 54 . 9/7/2013
This whole story reminded my of Fruit Basket and I LOVE it one of my top anime! Love the soft and peaceful ending...One of my favorites from you
| Guest chapter 54 . 8/29/2013
It was so *sniff* beautiful!
| sk8boards4ever chapter 54 . 7/16/2013
| Mickyg Luvs Most Stuff chapter 10 . 4/8/2013
Wasn't Kate born and raised in Songtown, not Vientown? And isn't Vientown in Almia as well?
| izzy2498 chapter 54 . 3/9/2013
again *sniff* so beautiful u rock! if i had a gracidea flower i give a bouquet
bravo cant wait 4 the next one send me the link
| izzy2498 chapter 53 . 3/9/2013
i...i...*cries* l love this part it so beautiful u rock girl
dont give up on these stories there my favs u rock x2
im ur biggest fan


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PlayStation 4™ | Playstation Vita™ | PlayStation 3™ | Xbox One™ | Xbox 360™ | Nintendo Switch™ | Nintendo 3DS™ | PC Games | Other systems
Top Spin 3
D3 PublisherCompatible with Nintendo™ Wii (Wii™)
For JPN/Asian systems only.
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- Compete in addictively fun multi-player mini-games or rise through the ranks in Career Mode to become the #1 player in the world
descriptionFor the 1st time ever on the Wii, play with or against 16 of the world's top tennis pros at 10 real-life courts. Take advantage of complete Wii Remote™ functionality to perform forehands, backhands and serves exactly as you would swing a real racquet. Compete in addictively fun multi-player mini-games or rise through the ranks in Career Mode to become the #1 player in the world.
The gameplay in Top Spin Tennis will feature an array of modes including singles, doubles, mixed and non-mixed matches, exhibition, tournament and more, with four levels of difficulty and ten international venues. It will also feature more than a dozen licensed tennis stars as well as ten original characters. Up to four players can play Top Spin Tennis using as many as four sets of controllers. To add to the group fun, there are a collection of party games included.
further info
|Official Release Date
|Sep 03, 2009
|CERO A (Free)
|Catalog No.
|Item Code
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Have a good time but keep an eye on the crumb-snatchers. There are places and things that can cause serious injury, be sure to bring along the camera. Go in Spring thru late Fall... read more
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Is this attraction good for big groups (greater than 5)?
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Would this be a good sunny day activity?
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Thanks for helping!Share another experience before you go.
Have a good time but keep an eye on the crumb-snatchers. There are places and things that can cause serious injury, be sure to bring along the camera. Go in Spring thru late Fall... read more
Have a good time but keep an eye on the crumb-snatchers. There are places and things that can cause serious injury, be sure to bring along the camera. Go in Spring thru late Fall. Allow 2-4 hours. Wheelchairs/Crutches not advised.
As State Parks go this one was run Fantastic. With Full hook ups. Sites we a little small, but doable. Only one issue I didn't like was each road had Rv only on one side and tents only across the street from you. Kinda odd, but not a real issue. Having the river right next us was a Huge plus.... More
We stopped here for an overnight stay in our VW Weekender camper. We had the trip planned ahead of time and used the online booking service to reserve a spot in the campground / rv park that is part of this park. The campground/park is nestled in the trees and is very clean. You can tell that it is well-kept.... More
This was a very enjoyable walk (stretch of the legs from long drive). Myself and family have all been loggers. This is set up well for telling the history of logging, clearly for all to appreciate. Plus there is a walk by the river for nature lovers.
Then realized what the museum was and we had been wanting to see it for a long time. I have logging in my family although my husband doesn't. The two retired loggers in the gift shop were fun to talk to and very knowledgeable. This outdoor museum is in amazing condition. I recommend it for all ages:)
This campground is a very nice campground for families, couples and single campers with rvs or tent camping. There are lots of hiking, fly fishing in Williamson River, and on the weekends activities for children or young adults. Across the Hwy 97 is the logging museum where there is a small gift shop, museum and pioneer village that is great... More
Collier State Park is overall a good camping destination, but has some definite pros and cons. Visiting in the summer means temperatures in the 90s, though it is dry and still and does cool off overnight. The driveways are paved and easy to angle into, and the huge sites are a combination of dirt, gravel, and pine needles. Despite not... More
Beautiful site with two small rivers, a logging museum, and lots of country to explore. For many this is a one night stop as a good campground near Crater Lake, but it is more than that. Three major fishing rivers nearby. Two of them run through the park. Lots of trails.
We spent 4 days at this state park, and like every state park in Oregon, it did not disappoint. The location is great, between beautiful Spring Creek and the Williamson River. While entering the park, one of the camp hosts stopped us and pleasantly assisted us to our space. The spaces our fairly open, but almost all of the fellow... More
Nice park, but sites are very open to each other. 1 washer & 1 dryer (Technically 2 dryers, but 1 is out of order. Most likely because they're vented together and the duct hasn't been cleaned) small machines and many times a wait to get your laundry in. The logging museum was very cool. An easy walk from the campground.... More
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If we are staying at the campground in our RV for the weekend, do our friends have to pay to visit us during the day on Saturday?


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Aside from the historical and emotional significance of the South Africans' return to the cathedral of Welsh rugby after 25 years, it was neither the venue nor the opposition the tourists would have chosen for their opening match. They seemed in awe of both.
When the heavens opened just after the kick-off, the Springboks must have already been homesick. In the days when the river Taff was diverted through the Arms Park once a week and twice on Saturday afternoons, the ground would have been a quagmire. But although not ideal for adventurous rugby, the conditions alone could not be held responsible for the poverty of imagination and initiative displayed by both sides. The South Africans have the greater cause for concern.
Their line-out was a mess and their scrummage bereft of menace. As a result we saw little of their speed behind the scrum - the backs preferring the shelter of the forward flock to which they returned time and again.
Dredging the memory, it is hard to recall a game with so little worthy incident. There was the line-out graft of Stuart Roy and Derwyn Jones, the honest endeavour of Hemi Taylor and Mike Hall, while the Springboks were well enough served by their captain, Rudolf Straeuli, and Mark Andrews, who took what worthwhile ball the tourists snaffled at the line-out. Andre Joubert was the outstanding performer, and one tackle by Joel Stransky on Nigel Walker in full flight was the only moment to savour.
For the rest, it was two poor packs on a off day, midfield muddle, a rising penalty count - another worry for the tourists - and handling which would have disgraced the Tooting Bec Heavies. Even the solitary try was scarcely notable, being the result of lamentable defence when Joost van der Westhuizen was allowed to run 40 yards almost unhindered from a ruck. That brought the tourists to within a point of Cardiff, for whom Adrian Davies and Chris John had kicked penalties. How sorely the home side missed the cutting edge which Mike Rayer would have supplied from full- back.
One mistake followed another until Stranksy's penalty put the tourists into the lead midway through the second half. His second, in injury time, gave the Springboks undeserved respectability.
As a serious contest, it finished some way short of the long-distance war of words conducted between the International Board currently meeting in Canada and the South African Rugby Football Union or, to be more precise, its president, Dr Louis Luyt. There have been some viperish exchanges in the last 24 hours. The IB opened with an instruction to Sarfu to conduct an investigation into remarks made by Luyt in last month's issue of Rugby World magazine which, say the Board, have brought the game into disrepute. In the article, Luyt was critical of the organisation of the World Cup and demanded that the game recognise the fact that it was no longer amateur.
Luyt has countered with a statement in which he regrets that the Board should concern itself with the trivia of a magazine article when there were so many topics of major importance to be covered. 'Although I accept the tone of my remarks in Rugby World may not have been to everyone's taste, I think the message was clear - the great issue now confronting the sport is not whether rugby union should stay amateur or turn professional, but whether we should admit what everyone knows is happening in every major country or whether we should sustain the amateur pretence.' Fair enough.
Slightly less fair, however, is the fact that, ludicrously, Dr Luyt, the great dictator, will be conducting the investigation into himself. Any bets on the outcome?
Cardiff: C John; S Ford, M Hall (capt), C Laity, N Walker; A Davies, A Moore (A Booth 30-35); M Griffiths, J Humphreys, L Mustoe, S Roy, D Jones, H Taylor, E Lewis, O Williams.
SOUTH AFRICA: A Joubert (Natal); C Williams (Western Province), B Venter (Orange Free State), P Muller (Natal), C Badenhorst (Orange Free State), J Stransky (Western Province), J Van der Westhuizen (Northern Transvaal), B Swart, U Schmidt, I Hattingh (all Transvaal), M Andrews (Natal), H Hattingh, R Kruger (both Northern Transvaal), G Teichmann (Natal), R Straeuli (Transvaal, capt).
Referee: J Fleming (Scotland).
- More about:
- Rugby Union
- Shane Williams
- Springboks
- Tourism


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Cream Stereo Lounge Premieres Tomorrow Night
It's been a busy time for debuting Valley nightspots.
Within just the past six weeks, not only did American Junkie and The Lodge pop up in Scottsdale, but the long-awaited SideBar finally opened its doors to the public.
Add Cream Stereo Lounge (4252 North Drinkwater Boulevard, Scottsdale, 602-222-9922) to the list, as the swanky new Scottsdale nightlife destination bows tomorrow night. And it's doing so in style with an elegant New Year's Eve Masquerade Ball (entitled "COME celebrate THE BEGINNING") that's almost certain to one of the hotspots for Auld Lang Syne.
According to its MySpace page, Cream (which is housed a few doors down from the equally-chic Pearl Sushi and Jackrabbit Lounge) is promising a mix "European vibe" with a rather refined style of ambience and entertainment. (By the way, is the URL for the joint some kind of catty swipe at Myst?)
Upcoming Events
Roger Waters
TicketsWed., Jun. 14, 8:00pm
TicketsFri., Jun. 23, 7:30pm
Gordon Lightfoot
TicketsSat., Jun. 24, 8:00pm
Brad Paisley
TicketsSun., Jun. 25, 7:00pm
TicketsWed., Jun. 28, 7:00pm
Besides an array of DJs spinning high-energy tracks from around the world, patrons will be treated to "romantic and symphonic sounds of live brass, strings, percussionists, and woodwinds" every night. Various "themed events" in the spirit of Cirque du Soleil will also take place, as well as a "nightclub bathtub show" (think Dita von Teese or other burlesque-style starlets).
If you're interested in attending tomorrow night's ball, visit this web site for $25 pre-sale tickets or call 480-717-6000 for table and bottle reservations. - Benjamin Leatherman
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A refreshing and uplifting choice! Smooth lemon ice cream with a zesty lemon ripple and a citrus burst. New for the Scooping trade for 2015.
Please note this flavour is only currently available to the Scooping trade (parlours, pubs, restaurants) in 4L and 5L tubs. It is not currently available in the take-home 1L sized tubs. If you live near the farm then why not visit our farm ice cream parlour to try some!
Typical values per 100g (via calculation)
For allergens please see ingredients listed in bold
Fresh farm milk (50%), double cream (milk)(17%), sugar, lemon crunch (6%) [sugar, water, glucose syrup, natural colour (curcumin), natural lemon flavour, acidity regulator (citric acid), coconut oil, glazing agent (beeswax)], lemon ripple (6%) [sugar, lemon juice (20%), water, maize starch, concentrated lemon juice (4%), natural flavouring, natural colour (lutein)], lemon juice compound (3%) [water, lemon juice concentrate (32%), acidity regulators (citric acid, sodium citrate), natural flavouring], milk solids, dextrose, emulsifier (mono and diglycerides of fatty acids), stabilisers (locust bean gum, guar gum, carrageenan), glycerine.
Made in a factory which uses Soya, Wheat gluten, Egg and Milk.
Our suppliers cannot guarantee that their ingredients are free from traces of Nuts


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|Transact Technologies Inc
|Computer Systems
|Tact Home Co Ltd
|Real Estate Services
|Tactical Air Defense
|Aerospace & Defense
|Tac Tarim Urunleri Hayvancilik Gida Sanayi ve Tica
|Farm Products
|Tactile Systems Technology Inc
|Medical Devices
|Tactex Controls Inc
|Computer Systems
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Research article
Study of carrier concentration profiles in Al-implanted Ge by micro-Raman spectroscopy under different excitation wavelengths
Version of Record online: 14 MAR 2013
DOI: 10.1002/jrs.4249
Copyright © 2013 John Wiley & Sons, Ltd.
Journal of Raman Spectroscopy
Volume 44, Issue 5, pages 665–669, May 2013
Additional Information
How to Cite
Sanson, A., Giarola, M., Napolitani, E., Impellizzeri, G., Privitera, V., Carnera, A. and Mariotto, G. (2013), Study of carrier concentration profiles in Al-implanted Ge by micro-Raman spectroscopy under different excitation wavelengths. J. Raman Spectrosc., 44: 665–669. doi: 10.1002/jrs.4249
Publication History
- Issue online: 10 MAY 2013
- Version of Record online: 14 MAR 2013
- Manuscript Accepted: 11 DEC 2012
- Manuscript Revised: 14 NOV 2012
- Manuscript Received: 12 OCT 2012
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So our bathroom was pink.... pink walls, pink curtains... very pink. now don't get me wrong I like pink, but not in my bathroom, not in that quantity anyway.
Here's the result of a couple cans of paint:
sorry, this ones dark... but it give a fuller view of the bubbles.
Here's a
before/during in which you can still see the pink:
this is as finished as the bathroom will get for a while. I just really couldn't stand the pink bathroom... next redo we will have the tub and toilet moved, and a new vanity and new floors... Good thing my hubbys a plumber.... But for now a couple cans of paint will do. And belive you me, there will be bubbles in the next re-do too!


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Last week I wrote up a brief introduction to the doctrine of the Trinity. Over the next several Thursdays I'll tackle some of the different misconceptions and myths about the Trinity. Up first: Modalism.
One of the ways that people talk (incorrectly) about God is to say that just as one man can be a father, a son, and a husband, for instance, God also reveals Himself as Father, Son, and Spirit. The result of this analogy is Modalism: The belief that there is one God who reveals Himself in three different modes. It is as if God plays three different roles; in Modalism, the Father, the Son, and the Spirit are all the same person.
Modalism is also known as Sabellianism, as Sabellius espoused the doctrine in the third century. In fact, it found its origin in earlier teachers, such as Praxeas [see especially Tertullian, Adversus Praxeas, ch. 1]; Sabellius simply popularized it.
In contrast to Arianism, which also taught that there was only one God but denied that Jesus was divine, Modalism does teach that Jesus Christ is fully divine. What Modalism denies is that there are distinct divine Persons. Modalism is also sometimes referred to as Patripassianism (the belief that the Father was crucified in the Son) because Modalists deny that the Father and Son are co-existent persons; thus they teach that the Father is incarnate in the mode of the Son and suffers on the Cross.
The closest modern expression of modalism is found in the Oneness Pentecostal movement. There are some significant differences, but they both deny the persons of the Trinity.
The Athanasian Creed (the best explanation of the Trinity, bar none) shows us the two errors one may fall into regarding the Trinity: "[W]e worship one God in Trinity, and Trinity in Unity; Neither confounding the Persons, nor dividing the Substance." All Trinitarian heresies have their root in one of these two errors. In the case of Modalism, the Persons are confounded – they are not seen as distinct from each other.
To refute Modalism, all that must be demonstrated from Apostolic teaching is that the three Persons of the Trinity are co-existent; that is, that the Father, Son, and Spirit exist side by side at the same time. This is done simply: At the Baptism of Jesus, the Father speaks from heaven with approval of the Son, who is standing in the water, and the Spirit descends in the form of a dove (Matthew 3:13ff; Luke 3:21-22). Thus all three persons, Father, Son, and Spirit, are present (i.e. they exist) at the same time. The alternative, if Modalist doctrine is upheld, is that Christ was throwing His voice to speak from heaven!
You may not run into Modalism tomorrow (unless you're reading the Book of Mormon), but it certainly functions as a good example of bad teaching. It's still useful to us because it helps us to dig into Scripture and see what God reveals about Himself.
Next week I tackle Arianism. If you haven't subscribed yet, please do! Also, check out the blog on Facebook or follow me on Twitter for updates.


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ScanOps is based on Google Books images in which software distortions, the scanning site, and the hands of the book-scanning "ScanOps" employees are visible. Through varied analog presentations, the aesthetics of the images and the apparatuses that produced them are foregrounded over the originally intended content. These re-materializations are treated as photography— taking the form of framed image-sculptures, compiled in a mobile book-sculpture, and presented in a performance-lecture.
The project is an extension of Wilson's project Workers Leaving the GooglePlex, which investigates the marginalized, yellow badge-wearing class of ScanOps workers at Google's international corporate headquarters in Silicon Valley. Wilson documents the ScanOps workers, while simultaneously chronicling the complex events surrounding his own dismissal from the company. The reference to the Lumière Brother's 1895 film Workers Leaving the Factory situates the video within motion picture history, suggesting transformations and continuities in arrangements of labor, capital, media, and information.
Wilson's performance-lecture, Movement Materials and What We Can Do, will be held at Prarie Production in July. In the presentation, Wilson employs corporate, academic and artistic lecture techniques to the intertwining concerns of his projects Workers Leaving the GooglePlex and ScanOps. Medium-specific considerations and various histories of film/video, photography and publishing media are addressed, emphasizing the materiality of both analog and digital media and the labor processes they entail.Read more about ScanOps and Workers Leaving the Googleplex on Rhizome and Buzzfeed. Andrew Norman Wilson is an Artist Based in Brooklyn.
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Paul Cowan and Michael Hunter


text:
Topics List
Book 4: Act 2 - Plot Thread
(4)"since when did we have the trip of Agatha to Paris as being Agatha's second trip"? Second Journey is the name that Phil and Kaja have given to the set of
Alice Bentley
Apr 28
van Rijn's dilema
(7)... Fun Fact: All Jaegers have personally-engraved hand mirrors. How else can you tell if your hat is straight? ... Ha! I didn't notice the engraving until you
Apr 20
Collette getting Sparky?
(5)You may be right! I had forgotten the dangers there were to sparky girls, and it would make sense that Colette would feel the need to hide her spark. Good
Apr 16
Fetching Sponsored Content...
It's Anevka all over again.
(5)Nice comments Steve, and I was unclear. If all the time had passed and the up-to-date and modern state of our generation of heroic spark knowledge is still
Mar 28
Jumping Jagers
(7)Vell, ve do haf Oggie. Iz dat goot enuf?
Mar 27
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text: Vintage cotton tee in sea horse Item 01062 Size: Size Charts Quantity: 1 2 3 4 5 6 7 8 9 Add to Bag Wishlist Add to Bag Add To Wishlist share: Find In Store Please select a size above. size & fit Product Details Our superfine vintage cotton provides the perfect backdrop for a watercolor sea horse screen print painted by our graphic guru, Grace. Back in 2004, our design team set out to replicate a favorite worn-to-threads thrift-store tee. Years later, its gently heathered texture and covetable softness are legendary. Slim fit. Cotton. Body length: 24 1/4". Machine wash. Import. Item 01062.


text:
Yesterday I was surprised to learn I had been nominated for a blogging award by my incredible sister, Mara Rutherford. Although Mara is quite a bit younger than I, she's years ahead in the writing game and a huge inspiration to me. She has not one, but two great blogs: Scribble Babble (about writing) and Most Eligible Family (about her experiences with the US foreign service). And although this isn't really a writing blog (and it's pretty debatable how 'inspiring' it is), I am happy to play along.
The rules for the award are:
- Display the award on your blog
- Link back to the person who nominated you
- State 7 things about yourself
- Nominate 15 bloggers, link to them, and notify them about their nominations
Mara herself was nominated by the Sub It Club, a virtual support group for writers, which would have been at the top of my list. They also have a great list of blog nominees on their site, which I could have just copied here. But in the interest of not repeating previous nominees (as far as I know), here's a list of blogs that inspire me as an aspiriting writer:
And here are 7 things about me:
I used to work in film development and sometimes regret leaving that job.
I could not live without dark chocolate, café au lait and beurre Bordier.
Although I write middle grade, I probably read more YA.
Teleportation would totally be my superpower.
I am addicted to comedy podcasts.
I think about giving up writing at least once a day.
I love naps.
Now I just have to figure out how to notify these people that I nominated them. I think I still have a lot to learn about this blogging thing...


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Imagine you're playing a video game, but instead of getting frustrated by waiting while the game catches up with you, it keeps pace. It learns your behaviors and suggests weapons that you want, or tips that you need (because you can't get past that type of puzzle without a cheat).
It's like playing with your best friend, the one that actually knows you.
Welcome to the era of learning. It's an era powered by the IBM cognitive cloud. Cognitive gaming goes beyond artificial intelligence or rote machine learning. It gives developers insights in near real-time to make your experience better than you anticipated. These games anticipate your moves and help you level up faster.
To speed along advancements in this era, I am excited to announce three developments aimed to empower cognitive developers.
Partnership with PlayFab
Our first announcement is a new partnership with PlayFab, which will bring Watson's analytical abilities to the gaming industry. PlayFab is the most complete backend platform built exclusively for live games. In live gaming, factoring imagery and making real-time decisions is table stakes, that's why a game that learns with you cognitively is essential.
IBM Cloud for financial services
Next up is fintech. Fintech companies succeed when their services can draw deep insights while remaining secure. That's why we are excited to announce a new financial services platform. Newly available APIs for investment analysis and pricing that lets developers add better insights and recommendations to their financial applications.
Infrastructure for cognitive made easy
Finally, we focus on infrastructure. Competing in the cognitive era means creating and deploying secure apps quickly. That's why we're launching a new Bluemix container service that creates the first native Kubernetes experience to automatically dedicate and manage infrastructure needed to create, run, and secure an app with containers.
The only cloud built for the cognitive era
Diagnosing diseases. Predicting monsoons. Discovering patterns in human behavior — our needs, our frustrations, our aspirations — that call for a new app. One insight makes all the difference. We're proud to make the cognitive era a reality for more people developers every day. Join us in the cognitive era for free by trying Bluemix, and let me know how it goes @swaneroo.
I can't wait to play the next cognitive experience that you've built.
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245 Sierra Loop, Sartell, MN 56377
About the Listing
This model home is loaded with features, professionally built by Infinity Homes one of areas most trusted builders, upper level has 3 BRs & 2 BAs, irrigation/seeded/landscaped. HERS Energy score of 50. Desirable Sierra Cove Location.
Share Listing
Property Details for 245 Sierra Loop, Sartell, MN 56377
Bedrooms: 4
Bathrooms: 2 Full | 1 Three-Qtr | 1 Half
Lot Size: 0.32 Acres
Lot Dimensions: 160x92
Year Built: 2014
Garage Dimensions: 3 car
Garage: Attached Garage, Insulated Garage, Driveway - Concrete
Style: (SF) Four or More Level Split
Water: City Water/Connected
Sewer: City Sewer/Connected
Square Feet: 2454
Above Ground Sq Ft: 1608
Below Ground Sq Ft: 846 (approx)
Room Information for 245 Sierra Loop, Sartell, MN 56377
Main Floor
Living Room: 13x15
Dining Room: 10x11
Kitchen: 10x15
Lower Floor
Family Room: 34x14
Upper Floor
Bedroom 1: 12x14
Bedroom 2: 13x11
Bedroom 3: 13x11
Bedroom 4: 13x11
Dining Room Description: Kitchen/Dining Room
School Information for 245 Sierra Loop, Sartell, MN 56377
School District: Sartell-St. Stephens
School District Phone: 320-656-3715
Interior Features for 245 Sierra Loop, Sartell, MN 56377
Appliances: Range, Microwave, Dishwasher, Refrigerator, Freezer, Washer, Dryer, Air-To-Air Exchanger, Furnace Humidifier
Air Cond: Central
Heating: Forced Air
Fireplaces: Yes
Basement: (846 sq Finished) Walkout, Partial Finished, Drain Tiled, Drainage System, Sump Pump, Day/Lookout Windows, Concrete Block
Exterior Features for 245 Sierra Loop, Sartell, MN 56377
Lot Description: Irregular Lot
Lot Dimensions: 160x92
Roof: Asphalt Shingles, Pitched, Age 8 Years or Less
Zoning: Residential-Single
Financial Considerations for 245 Sierra Loop, Sartell, MN 56377
Tax Amount: $1,250
Taxes w/Assessments: $1,250
Tax/Property ID: 92571050367
Tax Year: 2015
Monthly Payment = $0
INRIX Drive Time
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The data relating to real estate for sale on this web site comes in part from the Broker Reciprocity Program of the Regional Multiple Listing Service of Minnesota, Inc. Real estate listings held by brokerage firms other than the owner of this website are marked with the Broker Reciprocity logo or the Broker Reciprocity thumbnail logo and detailed information about them includes the name of the listing brokers.


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Dresses Stunning Womens Dresses Online Lipsy.
Dress to impress in our latest collection of stylish dresses available in our new season colour palette. Create a flawless silhouette for parties with our stunning lace bodycon ladies dresses and flirty prom dresses or make a glamorous entrance at those extra special events in our sweeping floor-length lace detail womens dresses. Discover the perfect dress for all occasions in our latest season collection. Fitted dresses in short midi and long lengths give you plenty of options for every party invite.
Dresses Online Shop Women's Dresses Ladies Dress Pink Boutique.
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|Publication number
|Publication type
|Application number
|Publication date
|Dec 4, 1990
|Filing date
|Jun 16, 1989
|Priority date
|Jun 16, 1989
|Fee status
|Also published as
|Publication number
|Craig E. Jahr, Robin Lester, Eckard Weber
|Original Assignee
|The State Of Oregon Acting By And Through The State Board Of Education On Behalf Of The Oregon Health Sciences University
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (1), Non-Patent Citations (16), Referenced by (28), Classifications (4), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
The invention relates to therapeutics useful in neurologic diseases. More particularly, it concerns the use of nitroquinoxaline-2,3-diones in the treatment of degenerative diseases of the nervous system.
It has been recognized for some time that the transmission of signals through the nervous system is mediated by a variety of neurotransmitters, each of which has a complementary receptor in the neuron. A substantial number of classes of neurotransmitters and their receptors have been recognized.
One important excitatory neurotransmitter is the amino acid L-glutamate. Receptors which respond to this amino acid have been divided into NMDA and non-NMDA receptors; NMDA, N-methyl-D-aspartate, is an additional neurotransmitter which has its own class of receptors. NMDA receptors are known to be regulated by a glycine binding site which regulates the ability of the neuron to respond to NMDA; glycine in nanomolar concentrations potentiates the NMDA receptor-induced current in a strychnine insensitive manner. Substances which behave as agonists or antagonists with respect to NMDA receptors can therefore interact either with the receptor site for NMDA or the receptor site for glycine or both. Antagonists for these NMDA receptors ameliorate the effects of L-glutamine and are therefore beneficial in the treatment of degenerative neural diseases which are characterized by abnormal neuronal stimulation, such as epilepsy, brain degeneration due to stroke or heart attack, Alzheimer's disease, Lou Gehrig's's disease, and Huntington's disease.
The compound 6-cyano-7-nitroquinoxaline 2,3-dione (CNQX) and the related compound 6,7-dinitro-quinoxaline-2,3-dione (DNQX) are known to depress the excitation of spinal cord neurons which are induced by the stimulation of non-NMDA receptors. See U.S. Pat. No. 4,812,458. However, it was also reported that these compounds had little or no effect on responses produced by NMDA (Honore, T. S. et al., Science (1986) 241:701-703; Blake, J. F. et al., Neuro Sci Let (1988) 89:182-186; Fletcher, E. J., Brit J Pharmacol (1988) 586-587; Dryer, J. et al., Neuro Sci Let (1988) 87:104-108).
Although others have shown that CNQX and DNQX do not interfere with the action of NMDA itself, it has been shown that DNQX produces a shift to the right in the NMDA concentration response curve and a decrease in maximal response at high antagonist concentrations (Birch, P. J. et al, Eur J Pharmacol (1988) 151:313-315. A similar result was noted when DNQX was replaced in these assays by compounds known to displace labeled glycine from the strychnine insensitive binding site (Kemp, J. A. et al., Proc Natl Acad Sci USA (1988) 85:6347-6350; Kestler, M. et al., Soc Neuro Sci Abst (1987) 13:760. As stated above, it is known that binding glycine to a regulatory site potentiates the response of these receptors to NMDA.
It has now been found that despite its apparent inability to interfere with NMDA stimulation, CNQX, DNQX and their analogs behave as antagonists with respect to stimulation to the NMDA receptor.
The invention provides useful compounds for therapeutic prevention and treatment of neuronal diseases which are mediated through stimulation of the NMDA receptor. Such diseases include Alzheimer's disease, Lou Gehrig's disease, Huntington's disease, epilepsy, and brain damage due to stroke.
Thus, in one aspect, the invention is directed to a method to prevent, ameliorate, or otherwise treat these diseases by administration of effective amounts of CNQX or DNQX or their analogs. In another aspect, the invention is directed to pharmaceutical compositions in unit dosage form which are useful in this method.
FIG. 1 shows the effect of two concentrations of CNQX on the response curve for the NMDA receptor in the presence of various concentrations of glycine.
FIG. 2 shows the effect of increased glycine concentration and increased NMDA concentration on CNQX antagonism.
FIG. 3 shows the inhibition of binding of labeled glycine to membranes in the presence of increasing concentrations of CNQX.
FIG. 4 shows a Scatchard plot of labeled glycine binding in the presence and absence of CNQX.
As used herein, CNQX and DNQX and their analogs refers to compounds of the formula: ##STR2## each X is independently nitro or cyano and each Y is independently a non-interfering substituent selected form the group consisting of H, lower alkyl(1-4C), CF3, and lower alkoxy(1-4C). Lower alkyl refers to a straight or branched chain hydrocarbyl substituent such as methyl, ethyl, isopropyl, or isobutyl. Lower alkoxy is a substituent of the formula -OR wherein R is lower alkyl as above defined. Particularly preferred are embodiments of the compound of formula (1) wherein both Y are H and both X are nitro or wherein both Y are H and one X is nitro and the other cyano, i.e., DNQX and CNQX respectively. Other preferred embodiments include those wherein both Y are methyl or wherein one Y is methyl and the other Y is H, and wherein X is as described above.
The compounds of formula (1) are useful in the treatment of conditions of the nervous system which are mediated by the NMDA receptor. It is understood currently that among diseases affected by the NMDA receptor simulation are epilepsy, Alzheimer's, Lou Gehrig's disease, Huntington's disease and brain degeneration caused by stroke or trauma. However, any disease currently understood to be a function of NMDA receptor stimulation or subsequently shown to be thus mediated is a suitable substrate condition for the administration of the compound of formula (1).
In the method of the invention, the compounds of formula (1) are administered to subjects showing the above-mentioned indications in suitable pharmaceutical compositions and by routes of administration ordinarily used for simple compounds which target the nervous system. A preferred mode of administration is by injection, either intravenous, intramuscular, or subcutaneous, particularly subcutaneous injection in areas, such as immediately behind the ear, wherein the neuronal system can be reasonably directly addressed. Other routes of administration are also possible, such as application across membranes, e.g., transmucosal administration or transdermal administration. Oral administration can also be used.
The formulation and dosage range depend on the route of administration, the condition of the subject, and the judgment of the physician, and can be optimized using standard procedures for designing dosage. For administration systemically through injection, a suitable dose is in the range of 0.1 ug/kg-1 mg/kg. However, smaller and larger doses may be required depending on the specific situation.
For administration by injection, the compounds of formula (1) are administered in solution or suspension in suitable excipient, such as Hank s solution, Ringer's solution, physiological buffer in general, or water for injection. For transmucosal administration, suitable excipients include membrane penetrants such as bile salts and the fusidates. The materials for transmucosal administration can be formulated as sprays or suppositories. For oral administration, the compounds of formula (1) are administered in capsule, tablet, or liquid form. Suitable methods for formulation and administration are understood in the art, and an encyclopedia of such approaches can be found in Remington's Pharmaceutical Sciences, Mack Publishing Company, Easton, Pa., (latest edition).
The compounds of formula (1) are generally available commercially.
The following examples are intended to illustrate but not to limit the invention.
In a modification of the method of Jahr, C. E. et al., Nature (1987) 325:522-525, hippocampi were dissected from brains of 1-3 day old Long-Evans rats, chopped into blocks of less than 1 mm3 and transferred into a papain solution (20 units/ml) in which they were incubated with constant agitation for 30 min at 37� C. The tissue was dissociated into a single cell suspension in complete growth medium (minimum essential medium with Earle's salts, 20 mM glucose, 50 units/ml penicillin/streptomycin, 5% host inactivated fetal calf serum and 1:1000 serum extender) that contains 2.5 mg/ml bovine serum albumin and 2.5 mg/ml trypsin inhibitor using a fire-polished Pasteur pipette.
The suspension was plated onto glass cover slips coated with poly D-lysine (0.1 mg/ml) and collagen (0.5 mg/ml). One-half of the growth medium was exchanged every 2-3 days, and when the astrocytes were 80% confluent (4-7 days) 5 mM cytosine arabinoside was added to prevent further division of glial cells. After 7 days in culture, neurons were killed by incubation for 30 min in a balanced salt solution containing 100 mM glutamate. This provided a confluent non-neuronal background feeder layer on which newly dissociated neurons could be plated at low density, thereby minimizing synaptic contacts and reducing transmitter release resistant to tetrodotoxin (TTX).
Neurons maintained in culture for 1-3 weeks were dissociated and plated on the confluent layer for electrophysiology experiments.
The frontal cortex from frozen guinea pig brains was homogenized in 10 volumes (w/v) of 0.32M sucrose. The homogenate was centrifuged (1000 x g, 10 min, 4� C.). The supernatant was recovered and centrifuged at 20,000 g, 20 min, 4� C. The resulting pellet was resuspended to a protein concentration of 2.5 mg/ml using the method of Bradford, M. A., Anal Biochem (1976) 72:248-254 and stored at 20 ml aliquots at -70� C. for at least 45 hours before use.
For assay, the crude membranes were thawed the same day and resuspended in assay buffer (50 mM tris/citrate, pH 7.2). The membranes were then centrifuged at 20,000 x g for 20 min and resuspended in assay buffer to a protein concentration of 2.5 mg/ml. The preparation was treated with 0.1% Triton X-100 and 0.1% EDTA on ice for 20 min to remove endogenous ligands. The suspension was centrifuged for 20 min at 20,000 x g to recover the membranes. The membranes were washed before the assay an additional 3 times with assay buffer.
NMDA receptor-mediated currents were measured using tight seal whole cell patch recordings at room temperature (25� C.) using the dissociated neurons prepared as described in Preparation A. The recordings were made using an Axoclamp to an amplifier in discontinuous voltage clamp mode (switching frequency 10-15 Hz) or an Axopatch 1B patch clamp amplifier. The currents were low pass filtered (300-1000 Hz) and recorded on a Gould chart recorder or digitally sampled at 50-200 Hz. The cells were voltage-clamped at -60 mV.
In the assay, patch pipettes were filled with an intracellular solution containing 160 mM calcium gluconate, 10 mM CsCl, 1 mM EGTA, 1.5 mM Mg-ATP, 5 mM HEPES, adjusted to pH 7.4 with CsOH. During recording, the cells were continuously superfused (2-5 ml/min) with an external solution containing 165 mM NaCl, 3 mM KCl, 2 mM CaCl2 and 5 mM HEPES adjusted to pH 7.4 with NaOH. A 0.5 uM solution of TTX was added to reduce spike-triggered synaptic activity, and 100 uM picrotoxin in 1 μM strychnine were added to the external medium. Solutions containing test materials were prepared in the external medium and applied close (less than 10 um) to the cell under study through multi-barreled perfusion pipettes which enable rapid switching between solutions as described by Johnson, J. W. et al., Nature (1987) 325:529-531. One of the barrels always contained external buffer alone which provided rapid washout after application of the test substance. Solution changes were complete in less than 200-250 msec as judged by the time to peak response to a non-desensitizing concentration of NMDA/ glycine.
NMDA receptor currents were measured in the presence of varying concentrations of glycine in the presence and absence of CNQX. Solutions containing NMDA and the designated glycine concentration were added with and without CNQX as described above. The effect of CNQX on NMDA receptor mediated currents are shown in FIG. 1. In the experiment there shown, the neurons were voltage-clamped as described at 60 mv in each cell, 3-5 separate points were obtained with reference to a standard and the data were fitted to a logistic equation by the least squares method. The error bars indicate the standard deviation.
In FIG. 1, the solid squares show the effect of varying concentration of glycine on the receptor-mediated currents stimulated by NMDA in the absence of CNQX. The solid circles show this effect in the presence of 10 uM CNQX; the solid triangles in the presence of 30 uM CNQX. As the results in FIG. 1 indicate, higher concentrations of glycine are necessary to obtain potentiation of the receptor-mediated currents in the presence of higher concentrations of CNQX, and complete potentiation is not achieved in the presence of this compound.
Receptor-mediated currents were measured as in Example 1 in the presence of 30 uM NMDA. In the presence of 1 uM glycine, as shown in FIG. 2A, the presence of 10 10 uM CNQX suppresses the response. However, when the glycine concentration is elevated to 100 uM, the addition of 10 uM CNQX has substantially no effect. The relatively low suppression shown by 30 uM CNQX in the presence of 30 uM NMDA and 200 uM glycine can be reversed as shown in FIG. 2B by enhancing the concentration of NMDA to 500 uM. Thus, the effect of CNQX antagonism can be reversed by very high concentrations of either NMDA or glycine.
The effects of CNQX as described in this example and Example 1 were not dependent on membrane potential as currents recorded at +40 mv and -40 mV were substantially identical.
In an additional control experiment, the effect of CNQX on stimulation of the non-NMDA receptor for kainate, known to be antagonized by CNQX, could not be reversed by glycine. In this experiment, the neuron preparation described in Preparation A was treated with 20 uM kainate and 1 uM glycine in the presence and absence of 10 uM CNQX. As expected, the CNQX resulted in a complete suppression of the kainate-mediated current. A glycine concentration of 1000 uM had no effect on this suppression.
Washed membranes prepared as described in Preparation B (150-200 ug) were incubated with 4 nM 3-H-glycine (43.5 Ci/mmol) and unlabeled test substance or buffer in a final volume of 0.2 ml. After incubation on ice for 30 min, the reaction was terminated by rapid filtration at 4� C. using no. 32 glass filters (Schleicher and Schuell) pretreated with 0.05% polyethyleneamine. The filters were washed with 5 ml cold assay buffer and radioactivity was measured by liquid scintillation counting. Nonspecific binding measured in the presence of 1 mM glycine varied between 5-10% of the total 3H glycine binding. Saturation data were evaluated by Scatchard analysis using EBDA and LIGAND data analysis programs.
The effect of CNQX on the binding of labeled glycine is shown in FIG. 3. As shown, CNQX has an IC50 value of 5.7 uM for displacement of glycine. A Scatchard plot of these data is shown in FIG. 4.
An injectable preparation buffered to pH 7 is prepared having the following composition:
______________________________________Ingredients______________________________________CNQX 0.2 gKH2 PO4 buffer (0.4 M solution) 2 mlKOH (1 N) q.s. to pH 7Water (distilled, sterile) q.s. to 20 ml______________________________________
A pharmaceutical preparation for transmucosal delivery has the following composition:
______________________________________Ingredients______________________________________CNQX 0.1 gphosphate buffer (0.2 M, pH 7.4) 4 mlbile salts 0.1 gwater (distilled, sterile) q.s. to 20 ml______________________________________
A pharmaceutical preparation for oral delivery has the following composition:
______________________________________Ingredients______________________________________DNQX 0.1 gfumaric acid 0.5 gsodium chloride 2.0 gmethyl paraben 0.1 ggranulated sugar 25.5 gsorbitol (70% solution) 12.85 gflavoring 0.035 mlwater (distilled) q.s. to 100 ml______________________________________
|Cited Patent
|Filing date
|Publication date
|Sep 2, 1987
|Mar 14, 1989
|A/S Ferrosan
|6,7-disubstituted-2,3-dihydroxyquinoxaline compounds, pharmaceutical compositions thereof, and their use as neuroleptics
|Birch et al., Eur. J. Pharmacol. (1988) 151:313 315.
|Birch et al., Eur. J. Pharmacol. (1988) 151:313-315.
|Blake et al., Neuro Sci. Let. (1988) 89:182 186.
|Blake et al., Neuro Sci. Let. (1988) 89:182-186.
|Chem. Abst. 109:14034u (1988).
|Drejer et al., Neuro Sci. Let. (1988) 87:104 108.
|Drejer et al., Neuro Sci. Let. (1988) 87:104-108.
|Fletcher Brit. J. Pharmacol. (1988) pp. 586 587.
|Fletcher Brit. J. Pharmacol. (1988) pp. 586-587.
|Honore et al., Science (1986) 241:701 703.
|Honore et al., Science (1986) 241:701-703.
|Kemp et al., Proc. Natl. Acad. Sci. U.S.A. (1988) 85:6347 6350.
|Kemp et al., Proc. Natl. Acad. Sci. U.S.A. (1988) 85:6347-6350.
|Kestler et al., Soc. Neuro. Sci. Abstr. (Abstr. (1987) 13:760.
|Lester et al., Mol. Pharmacol. (1989) pp. 1 6.
|Lester et al., Mol. Pharmacol. (1989) pp. 1-6.
|Citing Patent
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|Triazolo quinoxalines and their preparation and use
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|The State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University
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|State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon
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|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification
|Jul 17, 1989
Owner name: STATE OF OREGON ACTING BY AND THROUGH THE STATE BO
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:JAHR, CRAIG E.;LESTER, ROBIN;WEBER, ECKARD;REEL/FRAME:005101/0900
Effective date: 19890621
|May 16, 1994
|Fee payment
Year of fee payment: 4
|Jun 30, 1998
|Maintenance fee reminder mailed
|Dec 6, 1998
|Lapse for failure to pay maintenance fees
|Feb 16, 1999
|Expired due to failure to pay maintenance fee
Effective date: 19981204


text:
Cooler Pacific Ocean May Explain Climate Change Paradox
Geege Schuman stashed this in Climate Change
Stashed in: Ecology!, Science!, Music Videos!, Weather!, Climate Change!
But overall, it's warming. "The Reality of Climate Change: 10 Myths Busted" (below) is a nice link.
The findings suggest that the flattening in the rise of global temperatures recorded over the past 15 years are not signs of a "hiatus" in global warming, but are tied to cooling temperatures in the tropical or equatorial Pacific Ocean. When the tropical Pacific naturally switches back into a warm phase, the long-term trends in global warming, including more steeply rising global temperatures, will likely increase, said study co-author Shang-Ping Xie, a climate scientist at the University of California, San Diego.
"The engine driving atmospheric circulation on global scales resides in the tropical Pacific," Xie told LiveScience. "When the natural cycle shifts the next time to a warmer state, we're going to see more extreme warming on the global scale." [The Reality of Climate Change: 10 Myths Busted]
I seriously don't understand why we're arguing over the Pacific Decadal Oscillation and somehow acting like we don't know what's going on?
8 ways climate change is already changing the world:


text:
You've probably heard on the news something about ICANN and its "cozy relationship with the United States." So how does that affect both you and me?
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Vax Car Wash & Protect pressure washing detergent is for use with all Vax pressure washers. It aids the removal of tough dirt and oil from the exterior of all kinds of vehicles. The concentrated formula is diluted to give 5 litres of detergent.
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Date: Tuesday, 9th May 2017
Fasting till dusk
Nrsimha Chaturdasi is the divine appearance day of Nrsimhadeva, Lord Krishna's man-lion incarnation, who removes all obstacles on the path of devotional service out of His great compassion.
We are delighted to introduce the first edition of our monthly ISKCON-London newsletter.
This edition covers updates on events and activities that took place in January and February 2017 at the Temple.
We hope you enjoy reading it and please do share this with your teams and other contacts. We will be grateful if you could send us your feedback and comments at email@example.com.
Govinda's Restaurant Kitchen is looking for a Cake Baker and Porter.
Hours: Vary; Wage: Minimum
Govinda's Restaurant is looking for a volunteer Social Media Assistant to assist in marketing the restaurant.
Join us every Thursday from 6pm onwards in the Seminar Room for an evening of meditation, reading philosophy, singing, dancing and making new friends! (For ladies only). Dates and details for April are now available.
Dates: Every Saturday, 20th May - 10th June
Have you ever felt the need to approach a spiritual master? Am I ready to accept a higher authority? Who is a spiritual master? What are his qualifications? Is he God?
We are seeking a Temple & Restaurant Security Guard.
Days: Friday, Saturday & Sunday
Hours: 12pm - 9pm
Salary: Minimum Wage
ISKCON Founder-Acarya
His Divine Grace A.C. Bhaktivedanta Swami Prabhupada
If you would like us to keep you updated on the monthly happenings at ISKCON-London subscribe here.
Click here to go to the Temple Camera Video Stream page.


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Students, in teams, spread out on their half of the playing area and pass the ball from teammate to teammate, until the team goalie catches the ball. The goalies are placed on the opposite ends of where their teamates are.
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Meld is a visual diff and merge tool. You can compare two or three files and edit them in place (diffs update dynamically). You can compare two or three folders and launch file comparisons. You can browse and view a working copy from popular version control systems such such as CVS, Subversion, Bazaar-ng and Mercurial.
30 Day SummaryFeb 18 2017 — Mar 20 2017
12 Month SummaryMar 20 2016 — Mar 20 2017


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Stan Caldwell[Subject Prev][Subject Next][Thread Prev][Thread Next]
- To: <seaint(--nospam--at)seaint.org>
- Subject: Stan Caldwell
- From: "Brian K. Smith" <smithegr(--nospam--at)bellsouth.net>
- Date: Thu, 7 Apr 2005 15:47:39 -0500
I am looking for a bolt product you used on a roof retrofit a number of years ago. Please email me privately.
Brian K. Smith, P.E.
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