text: We're sorry, Cardamom Spiced Chocolate Coated Coffee Beans is no longer available Why not try one of these instead? Perfect Match Chocolates by Choc on Choc £8.99$15.42€10.77$11.51 Box Of Biscuit Shaped Chocolates by Choc on Choc £10$17.16€11.98$12.81 Chocolate Box With 'I Love You' And Name by Chocolate by Cocoapod Chocolate £9.95$17.46€12.13$13.13 We Make A Great Pear by Choc on Choc £9.99$17.14€11.97$12.80 Pinch to zoom Cardamom Spiced Chocolate Coated Coffee Beans by The Chocolatier £8.95$15.71€10.91$11.81 This item is no longer available Favourite Favourite View your favourites we're sorry we're sorry, This item is no longer available buy a gift voucher related categories weddings > more > food & drink > chocolates food & drink > tea time christmas > food gifts > sweet treats PRODUCT DETAILS ask seller a question save for later Served at the Le Meridien Hotel, Piccadilly - Slow roasted coffee beans coated in a cardamom spiked dark chocolate. This chocolate has been created to remind of a middle eastern coffee. Traditionally brewed with cardamom, the middle eastern coffee is quite magical. We slowly roast coffee beans so as to not bring out any bitterness and harness all the delicate flavour. These are then coated in a delicious cardamom infused dark chocolate. These chocolate dragees are perfect for sharing at dinner parties. Please see our full range on notonthehighstreet.com. made from: Coffee bean, dark chocolate, cardamom, soya lecithin, shellac. Dairy, gluten and nut free. Vegetarian. Made where dairy, nuts and gluten are present. dimensions: approx 135g 8x8x3cm product code: 291251 CUSTOMER REVIEWS 1 customer review read about our product rating system ratings guide trusted independent customer feedbackforum excellent bad good poor DELIVERY This product is dispatched to you by The Chocolatier. RETURNS You have 28 days, from receipt of cancellable goods, to notify the seller if you wish to cancel your order or exchange an item. Please note: goods that are personalised, bespoke or made-to-order to your specific requirements, perishable products and personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken are non-refundable, unless faulty. Read more about our returns policy.Should you choose to return or exchange your order you will need to deliver the item(s) to the UK, where this seller is based. The Chocolatier's return policy Please see notonthehighstreet.com's returns policy.


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- Condition: Used
- Make: Volkswagen
- Model: Beetle - Classic
- SubModel: Standard Beetle
- Type: Sunroof Coupe
- Trim: Factory Sunroof
- Year: 1974
- Mileage: 99,999
- Color: Blue
- Engine size: 1600cc
- Number of cylinders: 4
- Fuel: Gasoline
- Transmission: 4-speed
- Drive type: Manual
- Interior color: Blue and White
- Options: Sunroof
- Vehicle Title: Clear Want to buy? Contact seller!
1974 Volkswagen Beetle - Classic Standard Beetle
TWO FOR ONE SALE! I am including with "BUY IT NOW!" a second, rashed out 1974 Super Beetle as a parts car! All you need is a trailer to cart it away on. I am including the second car for free! If you do not desire the parts car, he price does not change.
1974 VW Beetle w/ rather rare operating factory sunroof. (NOT SUPER BEETLE!)
DRIVETRAIN: 1600cc engine and transmission are great. Like all carbureted Beetles, he starts hard when she's cold. You have to warm her up..and then she's good to go and runs like a bat out of hell. She drives out excellently, nd tracks true. EMPI "Monza"-type exhaust (rusty but solid).
BODY: Body is in very good condition. All four fenders were "smoothed" by a previous owner. This is a technique where body filler is added to "smooth" out, nd/or change the lines of the car, o there IS body filler on all four fenders. (Fender-top front turn signals were shaved by a previous owner.) Three small spots of surface rust are bubbling through the paint,and the point of the "trunk" lid, own below the latch, s completely rusted through, ut the door frames are solid as are the floor pans. Driver's door has some rust on the lower hinge, nd seems "sprung" and needs force to close properly. Rear, river's side fender has a small dent. Some body moldings were removed by a previous owner. Paint is decent other than the aforementioned bubbles. It appears thick to me; like it was applied by an amateur. Car was professionally lowered with coil-over shocks on all four corners. All the glass is good. Both sides roll down, ut need a guiding hand to do so. As I said, his model has the much-desired factory sunroof, nd it operates fine. The cables work PERFECTLY! When you crank it back, ou can see, rom the top, ome mild surface rust and the sealing gasket is missing. (I keep a tarp over it to keep it dry inside.) She has aluminum EMPI 8-Spoke Porsche wheels. No door keys! Headlight trim rings were sanded, rimed, nd painted flat black with clear satin topcoat. Tires have excellent tread on them, ut they are older.
INTERIOR: Carpet is good, rom EMPI. She has older EMPI racing seats installed, nd they are structurally great, ut the upholstery material is in poor condition. Front door panels are intact, ut rough. Rear side panels are missing. I was going to replace them all with diamond-plate, o I didn't sweat it. EMPI "T"-handle shifter installed. Headliner is mostly missing, ut what IS there is BAD!! It will need to be completely replaced. Dash was being prepped for a diamond-plate treatment, oo, o every dash-mounted item is simply hanging through the dash holes. NO SPEEDOMETER installed, ut with "BUY IT NOW!", will throw in one you can use when you get to that part of the project.
WIRING/ELECTRICAL: A previous owner rather hashed some of the electrical wiring, o it has headlights, ail lights, rake lights, ut no turn signals, o dash or interior lights, nd no hi-beams.
I bought this as a project, ut I have too many. Time to pare down a little and I've decided the bug is the one to go. I'm concentrating on my other projects, o my loss can be your gain.
Please note: This car runs and drives right now. You can hop in, ire it up, et her warm up, nd hit the road if you want, ut If it was me, 'd put it on a trailer because of the older tires, he lack of a speedometer and turn signals. That would, f course, e up to your good judgment.
I've been as completely honest and up front as I can be with my description, ut I implore you to come and inspect the car, r have an agent of your choosing to do so before you buy it. (I will do all that I can to accommodate any inspection avenue you choose.) I don't think I've missed anything, ut I'm only human. If you wish any additional pictures, r have any questions, lease post them and I will do my best to respond as promptly and as accurately as I can.
NOTE: This item is also offered for sale locally, o I reserve the right toend the saleif it sells to a local buyer.
1974 Super Beetle – It is a battered hulk, s you can see in the pictures, ut it has many parts that will interchange with the Standard Beetle, nd it is included in the sale, t no additional cost.
No engine, ransmission, pindles, uspension, heels, ires, tc. Does have Doors, indows, reastplate, runk lid, ll four fenders, urn signals, eadlight housings, eats, oor latches and handles, ront clip, tc. It will NOT roll, nd MUST be trailered! What parts you cannot use on the Standard beetle, ou can clean up and sell.
NOTE: Remember, he parts car is included for free. You can decline it, ut the price for the main vehicle will not change.

subset: commoncrawl


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Relevant offers
One of my responsibilities in the big picture was to encourage innovative, new industries to Invercargill, so it gave me great pleasure to open the new Taha Dross Recycling Plant at Tiwai Point last Wednesday, writes Tim Shadbolt this week.
OPINION: Not only were the representatives of this Bahrain company great hosts, but they are extracting more aluminium and producing environmentally friendly fertiliser from a product that has, in the past, caused this council huge headaches and heartaches.
In the 1980s, dross was recycled within the city by Haysom Metal Industries, but the plant caused vibrations and council was confronted by an ever-increasing army of angry Invercargill residents claiming that they couldn't sleep at night.
The council had no choice but to follow up these complaints, and when we outlined the problem to Haysom it simply closed up shop and walked away. Suddenly, the city inherited tons of "toxic waste". Then a ship full of dross in Sydney Harbour caught fire.
By the time I was elected in 1993, the warehouse at Bluff was in dire straits.
The roof was leaking and liquid dross was flowing on to the footpaths. A series of emotional and, at times, angry emergency meetings took place in Bluff.
These were chaired by me or Eric Roy and at one stage. Eric became so impatient about the exaggerated descriptions being circulated about this "toxic waste" that he offered to deposit it on his own farm.
The problem at Bluff was resolved when the city council decided to buy the warehouse and use it for the Bluff Oyster Festival.
The Richardson Group and the Tiwai Point Aluminium Smelter came to the party, and that problem was no longer a headache.
But we still have warehouses full of dross in the city and we do need a long-term answer. That's why it was good to see Invest South investing in the Taha project.
This local community investment agency is symbolic of the co-operation that can be developed by local trust money and international industries or international investors.
The new Taha recycling centre cost well in excess of $6 million and is ideally located within the Tiwai Point safety-security zone.
I'm always impressed by the rigorous safety regulations that are enforced whenever you visit the Tiwai smelter.
When I worked at Manapouri in 1967, we didn't get safety glasses or earmuffs and a man a mile got killed – there were 17 miles of tunnels and 17 men lost their lives. We were like Wild West cowboys compared with the strict health and safety regulations imposed by the Tiwai smelter. I call that progress.
Although I wasn't impressed by the role played by Mark Peck during the great Southland dross saga, I was impressed by his story of redemption featured in this newspaper.
Mark was Invercargill's MP for nine years, and during that time, he did what he thought was best for the city.
All right, he did fall flat on his face at the end of his term in office, but let's face it, we all have our moments.
Humans can be quite fragile at times. Perhaps we are not as clever as we like to think we are. I know that sounds like heresy, but let's just say that Mark has had a rough landing.
Then he picked himself up, dusted off his coat, and started again, this time in an inner-city Wellington coffee bar.
By coincidence, he ended up on the site of the student pub of the 1960s, The Duke.
It's great to see Mark get back on his feet. Let's face it, anyone can handle the sweet rose of triumph and success, but it takes real courage to handle the bitter lemon of defeat.
» Tim Shadbolt is the mayor of Invercargill.
- The Southland Times
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What do you want in a five star hotel?Related story: (See story)


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2 Henrico delegates offer different plans for reducing gun violence
By Maria Rajtik, Capital News Service 01/18/13
Two Henrico delegates agree measures need to be taken to lessen gun violence, but offer different approaches to regulation.
Del. Joseph Morrissey, D-Henrico, is focusing on a bill that would ban assault weapons and high-capacity magazines that hold 20 or more rounds.
HB 2207 would make the import, sale, barter and transfer of assault firearms a Class 6 felony, and the import, sale, barter and transfer of high-capacity magazines a Class 1 misdemeanor, respectively. Law enforcement officers and military personnel would be exempt from this legislation.
"To me it's an absolute no-brainer to ban these assault weapons," said Morrissey, who has served as a delegate since 2008.
The federal ban on assault weapons expired in 2004, and now Congress is considering reintroducing this legislation in the wake of recent mass shootings.
President Obama and Vice President Biden spoke on Wednesday encouraging Congress to pass legislation to help reduce gun violence including: stronger background checks, bans on assault weapons and high-capacity magazines, increased safety measures at schools and greater access to mental health services.
"I think Virginia ought to act now," Morrissey said. "There is no use, legitimate use, for these automatic rifles and high capacity magazines, save causing mass carnage and destruction."
The gunmen used these weapons and magazines in the mass shootings at Virginia Tech, Aurora, Colo. and Newtown, Conn.
"There is no place for these weapons except for perhaps on the battlefield," Morrissey said.
These guns are not used for sport, for target practice or for defending yourself, he said.
"A blind person, pointed anywhere near it, could hit a target with 100 shots," he said.
Del. John O'Bannon, R-Henrico, does not believe that the best route for reducing gun violence is through changing the current laws regulating firearms, but instead the focus should be on offering more help to people with mental illness.
"Virginia's already had one terrible disaster in a school at Virginia Tech," he said, "and we actually learned a lot from that. We responded and did some things to try to improve the way we handle folks who have mental heath issues, mental illness. And I really think we have a lot more opportunity to make things safer and reduce the chance of that happening in that venue."
Gov. Bob McDonnell put together a school safety task force with a group focusing on education and another focusing on mental health. O'Bannon is a member of the mental health portion of the task force under Bill Hazel, Virginia secretary of health and human resources. The group is meeting this afternoon.
HB 2207 was assigned to the House Militia, Police and Public Safety subcommittee #1, which was set to meet Jan. 17.
New conservation easement creates wooded buffer for Bryan Park
Citizen Staff Reports 04/21/2017 Features
Five years ago, members of the Friends of Bryan Park were facing the apparently inevitable development of the Shirley subdivision in Henrico, adjacent to the forested section of the park near the Nature Center and Environmental Education Area.
As part of the Shirley subdivision, the land had been divided into 14 lots in 1924, but had remained mostly undisturbed through the decades. In 2012, however, developers proposed building 40 modular houses on roughly 6.5 acres, clear-cutting the forest there and creating a highly dense neighborhood tucked into a dead end. > Read more.
As part of the Shirley subdivision, the land had been divided into 14 lots in 1924, but had remained mostly undisturbed through the decades. In 2012, however, developers proposed building 40 modular houses on roughly 6.5 acres, clear-cutting the forest there and creating a highly dense neighborhood tucked into a dead end. > Read more.
Meet the men running for governor
By Megan Schiffres, Capital News Service 04/21/2017 Government
Virginia will elect a new governor this year.
The governor's position is one of great power and influence, as the current officeholder, Terry McAuliffe, has demonstrated by breaking the record for most vetoes in Virginia history.
However, during the last gubernatorial race in 2014, the voter turnout was less than 42 percent, compared with 72 percent during last year's presidential election. > Read more.
RISC to address reading, childhood trauma, job training at assembly
Citizen Staff Reports 04/21/2017 Features
On May 1, more than 1,700 community members representing Richmonders Involved to Strengthen our Communities will gather at St. Paul's Baptist Church (4247 Creighton Road) at 7 p.m. to address elementary reading, childhood trauma and job training in the greater Richmond region. Community members will speak about each issue and proposed solution.
For three years, the organization has sought implementation of a specific literacy program in Henrico County that it believes would help children who struggle with reading. > Read more.
For three years, the organization has sought implementation of a specific literacy program in Henrico County that it believes would help children who struggle with reading. > Read more.
Henrico to begin update of zoning, subdivision ordinances April 26
Citizen Staff Reports 04/21/2017 Government
Henrico County is beginning a comprehensive update of its zoning and subdivision ordinances — the first such effort in six decades — and will introduce the project as part of the April 26 meeting of the Henrico County Planning Commission.
The meeting will begin at 9 a.m. in the Board Room of the Henrico Government Center, 4301 E. Parham Road. The ordinance update project will be featured as the final item on the agenda. Project consultant Clarion Associates will give a presentation, and meeting participants will be able to ask questions and provide comments. > Read more.
HCPS to present three-day ARTS Festival, beginning April 21
Citizen Staff Reports 04/21/2017 Education
Henrico County Public Schools' annual spring arts festival will celebrate its fourth year with a weekend of music and fine art. ARTS Festival events – the acronym stands for Artists, Residents, Teachers and Students – will kick off with a musical performance Friday night, April 21 and events will run through Sunday, April 23. This year's festival will be held at Henrico High School, 302 Azalea Avenue.
Friday night at 7:30 p.m. the Center for the Arts at Henrico High School will hold the first of two weekend performances of its Musical Theatre Showcase, a selection of musical numbers performed by Center for the Arts students. > Read more.
Villa's Flagler Housing wins national NAEH award
St. Joseph's Villa's Flagler Housing & Homeless Services was one of three entities to earn the National Alliance to End Homelessness' Champion of Change Award. The awards were presented Nov. 17 during a ceremony at the Newseum in Washington, D.C.
NAEH annually recognizes proven programs and significant achievements in ending child and family homelessness.
Flagler completed its transition from an on-campus shelter to the community-based model of rapid rehousing in 2013, and it was one of the nation's first rapid re-housing service providers to be certified by NAEH. > Read more.
RIR's Christmas tree lighting rescheduled for Dec. 12
Richmond International Raceway's 13th annual Community Christmas tree lighting has been rescheduled from Dec. 6 to Monday, Dec. 12, at 6:30 p.m., due to inclement weather expected on the original date.
Entertainment Dec. 12 will be provided by the Laburnum Elementary School choir and the Henrico High School Mighty Marching Warriors band. Tree decorations crafted by students from Laburnum Elementary School and L. Douglas Wilder Middle School will be on display. Hot chocolate and cookies will be supplied by the Henrico High School football boosters. > Read more.
Weekend Top 10
For our Top 10 calendar events this weekend, click here! > Read more.
HCPS to present three-day ARTS Festival, beginning April 21
Henrico Police apprehend shooting suspect
Third annual 'Sharing Smiles Day' offers free dental care for kids
Henrico Extension to offer free financial workshop April 27
Henrico Doctors' Hospital locations receive safety excellence award
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Print Edition
Apr. 19, 2017Click here to read the print edition.
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Henrico's Rayvon Owen among headliners at Live Art June 11
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|April 2017
Place an Ad | More Classifieds
CalendarThe WAY, located at 2 E. Williamsburg Rd. in Sandston, will hold its first Easter Grand Gathering event from 7 a.m. to 2 p.m. There will be a yard sale, vendor sale, bake sale, community lunch with hamburgers and hot dogs, music and silent auction. Kid's activities starting at 11 a.m. include games, bounce house, arts and crafts, Easter egg hunts, face painting and more. Open to the community. Proceeds benefit The WAY. For details, call 737-3300 or search "The WAY" on Facebook. Full text


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Bozzuto launches fund to fuel D.C. and Baltimore housing projects
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Federal Capital Partners Joins Level 2, Clark's Union Market Project, Plans To Break Ground Soon


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Marketed By :
LAP LAMBERT Academic Publishing
Sold By :
Kamal Books International
Delivery in :
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Availability: Out of stock
(Notify me when this product is back in stock)
This book describes the synthesis and characterization of niobium-based metal complexes and their usefulness as catalysts for the polymerization of ethylene, norbornene, beta pinene and vinyl monomers. The polymerization of above described monomers was studied using niobium complexes based on N,N dialkylcarbamates, mixed chloro alkoxides, simple oxygen-containing ligands and the starting material for the preparation of such derivatives, i.e. NbCl5.Niobium N,N-dialkylcarbamates exhibited high activity for polymerization of ethylene when activated with TMA-depleted MAO and 1,2-dichloroethane as activator working at 1 bar ethylene pressure. These novel catalytic systems resulted very active in Ring-opening metathesis polymerization (ROMP) of norbornene (NBE)with the highest activity never reported up to now for any transition metal catalysts. The dinuclear niobium compounds and simple oxygen-containing derivatives of niobium pentachloride were tested for ethylene polymerization and produced satisfactory results.In this context, it was found that easily accessible NbCl5 works as an excellent catalyst for the polymerization of ?-pinene styrene and butylvinyl ethers.


text:
Piston fountain pens
While filling hold the pen and the ink pot together.
Instructions for filling your piston fountain pens using the Visconti portable ink well.
To practice filling your pen, it is recommended that you try the following operation once or twice with water.
- Remove the stopper, pulling gently
- Fill the ink well with the dropper, taking care not to stain the seal
- Do not overfill!! The correct level is about 1 cm (1/4 inch) below the seal
- Unscrew the blind cap of the pen allowing any remaining ink to drop in the ink well
- Press the pen firmly in into the ink well (the section must secure the seal)
- Upturn the ink well and the pen
- Fill the pen and screw the blind cap back into position
- To increase the capacity of the pen, repeat the filling operation (unscrew the blind cap and screw it back into position)
- Turn until the pen is in the 12 o'clock position and the ink well in the 6 o'clock position and gently remove the pen from the ink well
- Carefully dry the nib and the filler
- Inside the stopper there is a piece of cotton wool in case of emergency. Lift the stopper with a coin


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Boeing Phantom Ray. Specifications. A photo.
Boeing Phantom Ray - American military multipurpose unmanned aerial vehicle developed in 2011, the company «Boeing Integrated Defense Systems».
Boeing Phantom Ray photo
Work on the creation of an unmanned Boeing Phantom Ray aircraft models have become a means carried by American engineers and scientists in the design of aerospace systems and aircraft, even in 2007 year. The new project was positioned as a promising military development, minimizes manned air assets in service with the US. With its broad functionality, an unmanned aerial vehicle can be used not only as an independent combat unit, but also as a means of intelligence, as well as to carry out patrol and observation and special operations.
The first flight of an unmanned aircraft model Boeing Phantom Ray funds held in 2011 year, however, despite the fact that most of the tests have been successfully completed, the project continued to improve. According to preliminary data, the final test of the new UAV Boeing Phantom Ray models are planned for the year 2017, while expect the drone in the armed forces of the USA should be no earlier than 2020 years, and it is provided that the UAV successfully pass all the tests set.
A photoBoeing Phantom Ray
Four high-precision missiles were armed drone Boeing Phantom Ray, allowing to destroy both ground and air targets, as well as two bombs, making it possible to deal with fortified ground targets.
Powerplant drone Boeing Phantom Ray presented a turbojet engine of the brand General Electric F404-GE-102D, whose power is 48,9 kN, which in turn provides the drone overclocking up to speed in 1020 km \ h., While the effective radius of the unmanned action means the order of kilometers 2400.
Specifications Boeing Phantom Ray.
- Length: 11 m .;
- Wingspan: 15 m .;
- Height: 3 m .;
- Maximum takeoff weight: 16550 kg .;
- Cruising flight speed: 990 km \ h .;
- Maximum flight speed: 1020 km \ h .;
- Maximum flight distance: 2400 km .;
- Maximum flight height: 12200 m .;
- aircraft engine type: turbojet;
- Powerplant: General Electric F404-GE-102D;
- Power: 48,9 hp
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House: Spacious kitchen, in-house laundry, parking, beautiful garden. Ducted heating with adjustable vents in each room. Logistics: 7 min walk to Macleod train station, 30 min on train drive to city centre. Bus 561 at your doorstep, bus 548 stops 5 min away. Very close to La Trobe University Bundoora campus (5 min on bus or 20 min walk, 10min on bike). Neighbourhood: Peaceful neighborhood, perfect if you want to be away from the bustle of the city, without being too far out. Green parks nearby, perfect for jogging. Rent includes: all bills, unlimited Telstra internet, laundry, basic household items and parking. House rules: 1) females only, 2) no smoking, no alcohol, no pets, 3) room is for one person. Guests are welcome but not for staying over on regular basis, 4) respect your housemates, care for each other's needs, 5) everyone cleans their own room and follows the cleaning roster for common-use areas. I am a European Russian Muslim, working full time as IT & tech copywriter. I don't drink, smoke or party. I am friendly and sociable in more meaningful ways. Love science & tech, enjoy reading, writing, going out in the nature. I speak English, Russian, German, Polish and Latvian. Second housemate is an Indonesian veterinary student at La Trobe University. Loves reading, watching movies and socializing, is friendly and respectful. Third housemate is a German student of Education at La Trobe. Works as a coach for children, loves to travel and learn new things. Friendly and responsible. Looking to share our place with mature and friendly girls who value clean, quiet and respectful housemates.
House: Spacious kitchen, in-house laundry, parking, beautiful garden. Ducted heating with adjustable vents in each room. Logistics: 8 min walk to Macleod train station, bus 561 at your doorstep. Very close to La Trobe University Bundoora campus (5 min on bus or 20 min walk, 10min on bike). 40 min train drive to city centre. Neighbourhood: Peaceful neighborhood, perfect if you want to be away from the bustle of the city, without being too far out. Green parks nearby, perfect for jogging. Rent includes: all bills, unlimited Telstra internet, laundry, basic household items and parking. House rules: 1) females only, 2) no smoking, no alcohol, no pets, 3) room is for one person. Guests are welcome but not for staying over on regular basis, 4) respect your housemates, care for each other's needs, 5) everyone cleans their own room and follows the cleaning roster for common-use areas. I am a European Russian Muslim, working full time as IT & tech copywriter. I don't drink, smoke or party. I am friendly and sociable in more meaningful ways. Love science & tech, enjoy reading, writing, going out in the nature. I speak English, Russian, German, Polish and Latvian. Second housemate is a Biotechnology Masters student at La Trobe University. Loves reading and watching movies, is friendly and respectful. Third housemate is a Veterinary Bachelor student at La Trobe University. Enjoys reading, watching movies and socializing. Looking to share our place with mature and friendly girls who value clean, quiet and respectful housemates.
Have a lovely room to rent in a friendly share-house with a long lease. There are currently two guys living in the other rooms who you would be sharing with, tidy, respectful and financially responsible. Pets welcome, smokers welcome. Have plenty of space to use or store your stuff if you have extra we have two sheds in the large backyard that is great for pets, plants and you. We also have a brand new shower. Any inquiries welcome, happy to help out.Pets Welcome New Shower and Toilet, Ducted Heating, Evaporative cooling
Hi there, I got a room to rent out in Macleod. It is a 2-bedroom 3-story townhouse (terrance) with 1 bathroom and 1 powder room. The house is fully furnitured but you feel free to bring your own if necessary. The house is located in a most convenient place in Macleod with doorstep access to cafes, restaurants, grocery shops, parklands, and train station (1 min walk). By train it takes about 30 min to the city in weekdays. La Trobe University is about 2 km away. I got a domestic shorthair cat. So if you are a cat person, that will be perfect. There are also cafes, restaurants, grocery shops just downstairs and the train station is only 3-min walk away. Let me know if you like to know more. The rent is $195/w and shared bills.
• Single furnished or unfurnished room to rent in Macleod for long term • $180 pw+ bills. Internet is included with unlimited data. • Walking distance to train station and bus stop. • Off-street parking available. I have a very clean, beautiful and comfortable room to rent in a two-bedroom stand-alone unit in Macleod. The house is located in a quiet and convenient area. It is approximately 10 min walk to the Macleod train station and 3min walk to the nearest bus stop. The house is about 3km to Latrobe University and it takes roughly 10 min to Latrobe Uni by bus. This is a newly purchased house and has been recently renovated. The house is spacious and the appliances in the kitchen and laundry are all new and available for your use. The room itself is tidy and nice. You can easily put either a double or queen size bed, plus a study desk. It also comes with a big built-in robe and plenty of room for storage. The room currently has a double size bed and mattress, a study desk/chair and a book shelf. These are all for your use. You can also bring in your own furniture if you prefer to have an unfurnished room.
The house is in a perfect location for someone studying at La Trobe University, Bundoora, as it is only an 8 minute drive away. 10 minute walk and 3 minute drive to supermarket, shops, and the nearest train station. Your bedroom has built-in robes, a double bed and plenty of privacy. The bedroom joins onto a separate living area, which you will have primary access to. There are 2 bathrooms, and you will have primary access to 1 of them. Kitchen is shared. Priced at $150 per week; including bills and superfast, unlimited internet. Off-street parking is available, and there is a massive backyard. I'm open to pets but we would have to discuss first :)
Great location very quiet fairly new houses Veet friendly mates
We have a Townhouse to rent of 8 huge rooms. 4 Timbertglades Drive Bundoora Includes washing machine, dish washer, oven, fridge, huge living area and a big lawn back side, whole house is fully furnished. Parking both off site and on site. - one huge SUIT mainly for couple, if single person want to move we dont mind ($270-300 p/w including bills) Includes personal big toilet, own store room or wardrobe room, king size bed,wardrobe, seating area, study table and fully furnished - one huge room ($200 p/w including bills) Includes king size bed, big wardrobe, seating area, study table and fully furnished. 10mins walking from the tram stop 86 8-9 mins walk from the public bus and la trobe glider stop. More convenient for la Trobe Uni and RMIT students. Feel free to contact me.
The perks of this house include it being situated on a quiet street, inbetween both RMIT and La Trobe University and is friendly for students, as well as being close to the Watsonia train station and shops. The house and room is fully furnished - however the bed can be removed if you wanted to bring your own.
Affordable two large bedrooms available for Students or Working Professionals. Close to uni, shops and public transport. Perfect location, walking distance to La Trobe Uni and only a few minutes' walk to the tram stop. Close to shopping centres. Equipped with central heating and cooling in each room, the accommodation is comfortable and safe. Bedrooms are fully furnished with beds, chairs and desks. The home comprises of a big living area including lounge suite and dining table. Kitchen includes large fridge, stove and microwave. Laundry is fitted with washing machine and dryer. Home features include: • Unlimited high speed cable internet (30 mbps) • Smoking allowed outside only • Fridge, lounge and dining setting • Lockable bedrooms and bathrooms • Newly refurbished bedrooms • New family sized washing machine • Off street parking • Queen sized bed / Double bed • Desk and study chair provided • Large built in wardrobe in room • 5 minutes walking distance to public transport • 10 minutes walking distance to Uni and shops Looking for friendly, clean, respectful house mates. If this sounds like the perfect home for you, please feel free to Message or SMS to organise an inspection.
Typical 3 bedroom house in Bundoora. Great property with backyard and large garage available. Air conditioning and heating. Off street parking is available. Great house and close to Plenty rd tram line. There are 2 rooms available for inspection, but I am only looking for one person to share with. Furnished or not. Comfy couch and and sunroom out the back.
Best location in Bundoora with great neighbours. Close to Plenty Rd tram, Bundoora shopping precinct, La Trobe University & RMIT University. 4 bedrooms, study, 2 bathrooms, 2 toilets, kitchen, meals, living, dining, lounge and retreat Heating, Cooling, solar electricity and double garage. Long drive to fit half a dozen cars. Great outdoor undercover entertaining area.
We're looking for a third housemate in our lovely home in Bundoora! The house is 3 bedrooms, with a decent sized lounge room and kitchen, shared bathroom with a separate toilet. We have a large backyard including two sheds and plenty of car parking space. We are super close to the 86 tram stop and walking distance to Bundoora Square shops and transport! Your unfurnished room is located at the back of the house and could easily fit a double bed, drawers and has a built in robe. Your monthly third of rent will be about $520, and then bills split evenly between us (Internet, gas, water, electricity). We are two easy-going and friendly girls, Shenae is 23 and studying at La Trobe and Chelsea is 20 and works full time. We're looking for someone of similar age, preferably female, but ultimately someone who is respectful, clean and trustworthy. Looking for someone who will be willing to sign on the lease. The availability date for this room is not super definite yet, however will be around June at the latest.. but we're happy to work something out with you. *room currently occupied by current housemate - but we are more than happy to organise an inspection time that works for everyone! Get in contact if you have any questions at all, or would like to meet up with us to discuss anything!
10mins walking to La Trobe Uni. (Save $40 myki cost weekly ) 500m to Polaris Shopping Centre, Woolworth, Subway, Cafe, Chemist Warehouse, Pizza Hut, Bottle Shop, Chinese restaurant, grocery, Viet restaurant etc 500m to Officeworks 2 mins walking to Tram 86 stop 62 4km to RMIT Bundoora campus, 6mins by driving Unlimited Wifi. 65' satellite TV No need to do your dishes here, as we have a DISHWASHER $190/week, big bedroom with single bed, and all furniture, available from 04 April 2017 All rooms are for one person, no couples. Clean, responsable, and honest people needed!. All rooms are for one person, NOT for COUPLES or 2 PPL. A reference letter from former landlord is preferred. Shortest lease is 1 month! Please tell me a bit about yourself FIRST. Such as where you are from, age, gender, studying or working, when to move in and out, etc PLEASE! Read the AD before contacting. People with fancy way of using toilets, like flooding toilets, please do not contact! (cdma.liXhoXXXXX.XXX)
Three years old apartment on top floor, fully equipped and furnished, NBN internet connected. Looking for a male roommate to SHARE my apartment , looking for quiet, extremely clean, responsible and friendly student or professional. I enjoy cultural exchange with international students and professionals. Not comfortable with partners sleeping over... Non smoker and a person who takes pride in both physical hygiene and house standards. Private room available from 30th of March 2017 price is $230.00 per week bills included, unlimited NBN internet also included. Total amount per calendar month is $920.00. Room ready for immediate move in. If you are looking for a clean and safe place to live in and study you will love this one. New Polaris estate 3083 Downstairs you are presented with new shopping complex with cafes supermarket, chemist, take away food stores and restaurants. Walking distance to Latrobe uni. .. Tram line opposite estate, with routes directly to CBD or surrounding areas and markets. Also less then 15 minutes to RMIT Bundoora by tram. All interested applicants/ candidates must have a profile on flatmates.com.au.
large fully furnished rooms close to Latrobe and RMIT, Bundoora sqaure only 2 minutes walk, 86 tram stop 2 minutes walk, Grimshaw street bus stop 200 meters from the house, very close to Watsonia station by bus or car,
One or two bedrooms available! (3 bedroom house) House is located in the lusciously green north east suburbia. Heaps of parks, rivers and bike tracks around. Huge kitchen and front garden, it's a lazy 5 mins on foot to Watsonia Station and Bus 566 and super close to the ring road. Perfect for those around the Austin/Mercy Hospital, Latrobe Uni or RMIT Bundoora (post grad preferable).
A Bedroom with Own Bathroom is available in Bundoora for Students, Professionals, Work & Holiday Visa Holders & Travelers. $45 for a single $75 for a couple (per night) or $250 single $330 couples if you stay more than a week 7min Walking to Polaris Shopping Centre, Cafes & Restaurants, 2min walk to the Tram Stop to the City. Walking Distance to LaTrobe Uni. The Oval is at the door & just a walking distance to GYM & Pool. The Room is full of Light through the French Window toward the Park View. You will have lots of Privacy as the kitchen & living room are downstairs. You will have your Bright & Modern Bathroom. Bills, Linen, Toileteries & Cleaning are Included. Breakfast is Included. Dinner could be available in Extra Charge. Long or Short Term, up to you. Minimum 3nights Maximum 3months. The Payment (first week rent + the security bond) is Upfront. You will be required your Passport & Driving Licence while you stay with us.
Hi there! We are a young, friendly couple offering one bedroom to you. We both work full time, easy going, considerate and easy to get along with. We love to get out and about with our dog "Missy". We love the occasional chat but also respect one's privacy. We also have a small dog and a indoor cat, so need to be pet friendly. Our house is 4 Bedroom, 2 Bathroom, 2 Living Area. Kitchen has recently been renovated and a spacious Alfresco Decking Area. There's secure off street parking if you have a car or a short walk to tram 86 and close to Bundoora Plaza. What we are looking for either female professional working full-time or female student. who is easy going, Independent, clean and can respect other peoples space. We're looking for a min stay of 6 months. If that sounds like you, feel free to give us a call for an inspection. Looking forward to meeting you!Spacious Pergola and Decking Area
The whole apartment is available and you will be taking over the lease!! This fully furnished near new apartment boasts an open plan lounge/meals area, with split system conditioning followed by two double sliding doors that open to your own private balcony. It has two generous sized bedrooms both with robes, modern kitchen with stainless steel appliances, bathroom and laundry facilities. It is situated across the road from La Trobe University and La Trobe Medical Centre. Its is also close to public transport, RMIT, Polaris Town Centre, Northland Shopping Centre, Uni Hill Shopping Centre, parks, schools, Metropolitan Ring Road and local supermarkets. Extra features include: entry intercom, remote secure parking, lockup storage cage, fridge and washing machine. Be quick as this opportunity it is too good to miss.
Light and spacious double bedroom available in two bedroom townhouse. Bedroom measures approximately 3.9 x 3.3m and includes built in wardrobe, ceiling fan and reverse cycle heating/cooling. Upstairs bathroom with bath and seperate shower. Downstairs kitchen, living, dining, laundry and second toilet. House is fully furnished including appliances - washing machine, dryer, fridge, dishwasher. Bedroom is furnished as shown. Courtyard compelte with BBQ, outdoor furniture and clothesline. Street parking only. Minutes walk to La Trobe University and Tram 86 (stop 60). Easy access to buses and equal distances from Reservoir and Macleod train stations. Close to Polaris and Summer Hill shopping centres. Bills addional and to be split equally between two. To share with 27 year old female working professional and 2 year old Jack Russell. Looking for single tenant, preferable female, must love dogs and respect space. Easy going, cleans without asking, respectful and sociable but appreciates personal space. Happy to share a meal and willing to walk Lulu every now and then would be a bonus.
This clean and tidy home is conventially located within 5 minutes walk to Plenty Road, Bundoora Shopping Centre, with easy access to tram or bus public transport which will take you to R.M.I.T or Latrobe University or into the city. This is a friendly household which will appeal to either full time students or professionals. The Lounge room has a comfy couch, TV and dvd player. The kitchen is has all amenities and the spacious laundry caters for all tenants. The first listed room has an ensuite bathroom, wardrobe and private access for the exclusive use of the tenant. PLEASE NOTE: MOBILE CONTACT PREFERRED . FEEL FREE TO CALL ROB WITH ANY QUESTIONS.. THANKYOU
We are looking for a fabulous person to join us in this beautiful leafy suburb of Bundoora . The house is located in a great location with something for everyone. Easy walking distance to public transport. Bus takes you direct to Reservoir train station and Northland Shopping Centre. Access into the city by train. My house only 8 minutes walking to Latrobe university and 1 minuet walk to the tram stop number 60. I have master room. Rent includes unlimited internet. Gas, electricity and water.
Room available in big house at panorama close Bundoora. Your bedroom is a double bedroom with single bed in it. Property has multiple bathroom and toilet. RMIT is 7 min from car and 15 min with public transport. La Trobe Uni is 6 min from car and 15 min with public transport $ 650 Monthly rent. includes, electricity, water, High speed Internet, Gas. Your room will be private. we prefer Indian student or professional person, but no couple. Woolworth, Aldi, Coles, Bundoora square at walking distance. Closest bus stop is 2 min walk, closest tram station within 5-6 min walk. Closes train station is Keon Pde, 7 min vis bus. Ample off street parking. Viewing available weekdays after 5pm and weekend anytime.
Great central location - close to buses, trains, and relatively close to two major shopping centres (Greensborough Plaza and Warringal). Quiet house with a large backyard in a leafy area. The room will fit a double bed, desk and shelves as well has having a built in robe and three speed ceiling fan.
Very comfortable house with all mod-cons in Bundoora - to share with 2 others. Features include; air-conditioning, living area heating, internet, dishwasher, clothes washer, storage room, BBQ facilities, neighbourhood views, electronic security. Private rear garden. Quiet location. Close to Parks. Darebin Creek and bike trail at rear. Very close to RMIT and LaTrobe Uni
Available for rent is the 1 bedroom in a fully furnished townhouse in Greensborough The house is in the best location. A couple of minutes walk to bus , train stations and Greensborough shopping centre. The bedroom features a double built in robes. The house has heating and cooling in each room. The whole house is fully furnished which includes a queen bed and bedside table in your room. shared bathroom also car park available in the lane way Must be employed or studying with a secure income. Cost is $180 per week includes bills Please inbox me for an inspection. I'm looking for someone who is clean, happy and likes dogs!
2 Large rooms available in share house. Both are partially furnished and needs can be met or removed if necessary. 4 bedroom house with ducted Heating Large back yard Off street parking (see above) 1 minute Drive from Latrobe Uni, 4 minute Drive from Austin Hospital, 5 minute Drive from Northland Shopping centre 4 minute Drive from Olympic Village Small Shopping Village 200m away Public Transport across the Road EVERYTHING is so Close.


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Links of London Wimbledon Script Bangle
Product code: 5012.0379
"If you can meet with triumph and disaster and treat those two impostors just the same"... This meaningful quote engraved on a classic bangle is inscribed above the entrance to centre court. A timeless piece, this silver bangle can be worn casually during the day or dressed up in the evening.
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Hugh Rice the Jewellers was established in 1971 as a family-owned and run business. From humble beginnings as a basement workshop to a chain of thriving high-street jewellery stores, including our new St Stephens store which is the largest in the region, we now stock some of the biggest concessions of fashion and exclusive brand names. As a specialist in diamond jewellery, the Hugh Rice brand has been famous for its value and classic beauty. We offer a comprehensive in-house jewellery design service to all our customers and our diamond jewellery is handmade and assembled in our open viewing workshop.


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From the classroom to the courtroom to a candidate for Nassau County's 19th District Legislator; Steve Rhoads got his first taste of politics when he was thirteen years old. Hoping to gain five extra credit points on his social studies grade and impress his homeroom teacher he decided to volunteer for her husband, state assemblyman Fred Perolla.
After volunteering in seventh grade, Rhoads found a future in local politics. He worked under Perolla for four more sessions in the state assembly in Albany before returning to Long Island to become a local committee person. Today he is running for Nassau County Legislator of the 19th district which runs from Freeport to Seaford, using many of the same techniques he learned from Perolla's campaign.
"I made the decision to run, to be perfectly honest, because I am tired of seeing all the gridlock," said Rhoads.
"I am tired of seeing all the Democrats refuse to work with Republicans, Republicans refuse to work with Democrats. People who are part of the middle, who are the ones that are paying the taxes, really need their government to work for them."
Dave Denenberg has had control over the 19th district of Nassau County for the past 14 years and has easily become a household name. Rhoads, the underdog in the election, has had the difficult task of not only introducing his policies but enforcing his credibility as a politician.
"He doesn't have the experience," said Claudia Borecky, the Public Relations Manager for Dave Denenberg.
"You need to work with government, and in government, to understand people's needs, the community's needs, your constituent's needs."
Rhoads may not have 14 years as a legislator to tote on his resume, but he is not unfamiliar with holding leadership roles in the community. Rhoads was the former Deputy Bureau Chief of the Nassau County Attorney's Bureau of Tort and Civil Rights Litigation. He currently practices law for Grey and Grey L. L. P. and is responsible for the firm's Long Island personal injury matters.
Rhoads was also captain of the Wantagh Volunteer Fire Department for five years, where he has served since 1992.
20 year old James Holman, a fellow Volunteer Firefighter for Nassau County and four year employee for Grey and Grey L.L.P. describes working with Rhoads as an enjoyable and learning experience.
"I believe that Steve's friendship with myself and the other clerks in the office has opened his eyes to the problems us young people will face in the future," said Holman.
"Housing in Nassau County is extremely expensive and the prospect of buying a house in the future for young people looks quite dim."
Lowering property taxes is just one of the policies Rhoads would like to implement if he receives Election this Tuesday night. His primary goal is to ease the burden on taxpayers by controlling county spending, reducing the size of government, and using industrial development agencies to bring business into Nassau County so that the economy can be expanded and jobs created.
"I think what gives me an advantage over Denenberg is I am trying to apply common sense solutions to a very real problem for homeowners," said Rhoads.
"Which is that between taxes, in every level of government, between increased expenses, it is getting very hard for them to be able to stay here in Nassau County. What's the point of having one of the nicest counties in the world to live in if nobody can afford to stay here."
The 19th district of Nassau County covers the towns of North Bellmore, Bellmore, Merrick, and parts of Freeport. Joan Brady, 55, has been a resident of the area of Freeport that runs under the 19th district for over 10 years. Her biggest problem with her district is the high taxes.
"God Almighty, the taxes are just so high! The school taxes, the real estate taxes, it just doesn't stop. When will it be easier for the middle class?" said Brady.
"14 years is just too long of a time, for Denenberg. I think it's time to get some new blood in the political scene."
Whether or not Rhoads wins the 19th District Nassau County Legislative Race or not, he will continue to serve Nassau County like he has for over the past twenty years.
"I have a career I am perfectly happy with, I didn't intend to run this year, "said Rhoads. "But I am because I'm frustrated with what I see and I'm trying to be part of the solution instead of part of the problem," concluded Rhoads.


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Author has written 1 story for Harry Potter.
Hi :) I LOVE Fanfiction! and am one of those people that has more favorites than personal storys : )
-Harry Potter (Hermione with Harry, Draco, Cedric, Oliver, George, and Fred (JK never should have killed him :.( )
-Smallville (Chloe and Oliver) and some Crossovers with Supernatural (Chloe and Dean) and with Batman (Chloe and Bruce)
-Stargate SG-1 (Sam and O-Neal)
-Stargate Atlantis (John and Teala)
-Southern Vampire Mysteries (Sookie and Eric)
-Vampire Diaries (Caroline and Tyler), (Caroline and Klaus) and (Damon and Elena) totally want them to end up together :)
-Some Glee (St- Berry)
-The Secret Circle (Cassie and Jake)
-Leverage (Parker and Eliot)
I hope to try out writing but we will see : )


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|Feb 2
|Toyotomi Hideyoshi regarded as Japan's second "great unifier." He succeeded his former liege lord, Oda Nobunaga, and brought an end to the Sengoku period. The period of his rule is often called the Momoyama period, named after Hideyoshi's castle. After his death, his young son Hideyori was displaced by Tokugawa Ieyasu
|Feb 2
|Piotr Skarga a Polish Jesuit, preacher, hagiographer, polemicist, and leading figure of the Counter-Reformation in the Polish-Lithuanian Commonwealth. Due to his oratorical gifts, he has been called "the Polish Bossuet"
|Feb 6
|Sassa Narimasa a Japanese samurai of the Sengoku through Azuchi-Momoyama period. Narimasa was born in what is now Nishi-ku, Nagoya , He became a retainer of Oda Nobunaga in 1550 and was granted Etchū Province as a reward for helping Shibata Katsuie fight the Uesugi clan. After Nobunaga's death, in 1584 he joined Tokugawa Ieyasu in unsuccessfully challenging Toyotomi Hideyoshi. He submitted to Hideyoshi and was spared his life. In 1587, he was given a fief in Higo Province in Kyushu. However, due to difficulties in suppressing a local revolt, he committed suicide by Hideyoshi's instruction in 1588. His daughter married kuge Takatsukasa Nobufusa and they had a son Nobuhisa
|Feb 24
|Pope Clement VIII Pope from 30 January 1592 to his death in 1605.
|Mar 10
|Thomas Howard 4th Duke of Norfolk an English nobleman.
|Mar 31
|Ashikaga Yoshiteru the 13th shogun of the Ashikaga shogunate who reigned from 1546 to 1565 during the late Muromachi period of Japan. He was the eldest son of the 12th shogun, Ashikaga Yoshiharu; and his mother was a daughter of Konoe Hisamichi. When he became shogun in 1546 at age 11, Yoshiteru's name was Yoshifushi ; but some years later in 1554, he changed his name to the one by which he is conventionally known today. His younger brother Ashikaga Yoshiaki would become the fifteenth shogun
|Aug 10
|Caspar Olevian a significant German Reformed theologian during the Protestant Reformation and along with Zacharius Ursinus was said to be co-author of the Heidelberg Catechism. That theory of authorship has been questioned by some modern scholarship
|Oct 21
|Joachim Ernest Prince of Anhalt a German prince of the House of Ascania, ruler of the principality of Anhalt-Zerbst from 1551, and from 1570 sole ruler of all the Anhalt lands.
|Oct 28
|Felix Plater a Swiss physician, professor in Basel, well known for his classification of psychiatric diseases, and was also the first to describe an intracranial tumour. He was born and died in Basel
|Nov 11
|Marcantonio Memmo the 91st Doge of Venice, reigning from July 24, 1612 until his death.
|Dec 26
|Yi I one of the two most prominent Korean Confucian scholars of the Joseon Dynasty, the other being his older contemporary, Yi Hwang. Yi I is often referred to by his pen name Yulgok. He is not only known as a scholar but also as a revered politician and reformer. He was academical successor of Jo Gwang-jo


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Numbness, Pain or discomfort, Unable to grip (palm) and Weakness from last month, Please advice.
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Frothy Melon Juice
READY IN: 5mins
Recipe by dimply dots
I heart my new juicer! Here is a super healthy and refreshing frothy melon-orange juice recipe for your juicer. Tastes like a melon smoothie!
Top Review by JanuaryBride
Fresh and light juice. My juicer recommends peeling cucumbers too. I love my juicer too :)
See Discussion:1 Review
Ingredients Nutrition
- 1⁄2 ripe cantaloupe, skin and seeds removed
- 4 -5 oranges, peeled
- 1 piece ginger, peeled (whatever size suites your taste, I use about 1 inch)
- 1 small cucumbers or 2 baby cucumbers
Directions See How It's Made
- After peeling all fruits whose skin can not be eaten, simply juice everything on low speed and enjoy. (Juice is even better when the fruit is cold before juicing). Feel free to substitute with other fruits and veggies of your choice.


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This is the full research report for 126.96.36.199, which is an IP address.
Bulsatcom AD
Stara Zagora
Bulgaria, Dynamic DHCP DDNS pool Stara Zag
Nikolay Hristov
bul.Carigradsko shose 7km, ZIT2, Fl.2, 1000 Sofia
Telephone: 359 2 4119646
Fax: 359 2 4119459
Blagovest Lazarov
Bulsatcom EAD.
Bul. Carigradsko Shosse 7km, ZIT 2, 1784, Sofia
Telephone: 359 2 4119646
Fax: 359 2 4119459
220.127.116.11 is the IP address you have a ran a report for on April, 30, 2017.
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text:
My City: Home (2)
Jena: Next Stop Paradise
Early in 2006, the headline of the British newspaper The Economist already read "If you seek paradise, go to Jena". In Germany, however, people aren't so sure about that. Wrongly so, thinks Ariane Kovac.
When I tell strangers which city I'm from, chances are that in 95%, they start to sing 'Bochum, I come from you!' ('Bochum' is a song by Herbert Grönemeyer, a popular German musician). That can be great, or not. The song is from 1984 and not everyone necessarily remembers the melody.
'Deep down in the west, where dust masks the sun, it's much much better than one might have known.' Great! Not even 10 seconds into the song, and one is already told that Bochum's reputation is the pits.
In fact, even if this usually entails a lot of sympathetic looks: there are people who come from Bochum, and there are even people who still live there. And even like living there.
And I dare to claim: there is culture in Bochum! Just now they are building a new concert hall – in which case one could ask if we really need it. In state of a musical emergency, all we'd have to do is take a left or a right on the A40 (Autobahn) and in 15 minutes either be in the concert hall in Dortmund or in Essen.
But hey, we want something of our own!
Inferiority complexes of a big city which is sandwiched between two even bigger cities. Bochum is the venue of the Ruhrtriennale, an international art festival. Bochum also hosts various music festivals, which are so highly frequented that the population density rivals that of Bangladesh. And since 1999, 'Bang Boom Bang' is screened every Friday in a movie theater in Bochum, without having been canceled once (negative record of visitors: 1).
In terms of culture, those who are unfamiliar with the place rather associate the city with 'Starlight Express'. A musical on roller-skates about the turbulent life of trains. Now, it's disputable whether this can already (or still?) be considered culture, but could 15 million visitors in 27 years be wrong? Perhaps one or the other musical tourist could be convinced to roll into the theater. Just once.
Into one of Germany's most renowned spoken theaters, where you are so warmly welcomed that you never want to leave. It's in this wonderfully consistent architecture of the 50s where they all get together in the evening: students, subscribers, honor classes in German from all Bochum high schools, parents in dating mood. A friend from the Rhineland once asked me if she should wear something fancy to the theater in Bochum. I would assume that since the wild directorship of a certain Leander Haußmann, the audience would probably be glad if someone wore clothes at all. Everyone may and should come. For a long time, there were company arrangements at the theater: discounted ticket fees for workers and employees of the big industries such as Krupp and Opel. Today, students in Bochum get a theater flat-rate of one (ONE!) Euro per semester. Structural change, mirrored: Opel shut down, Bochum's biggest employer is now the university.
Another interesting association that Bochum arouses in people is 'Bochum??? With the suicide uni?!'. Who ever it was who published this suicide statistics, it has certainly left a lasting impression. So it is hypothesized that people here jump to their death because the uni is sooo ugly. I find that exaggerated. It's just a concrete beauty, a jungled maze of rattling paving tiles, with underground parking landscapes and an incredibly lovely view of the Ruhr Valley. As the uni is situated on a hillside it lacks a classic ground floor which makes orientation in the multidimensional space extremely difficult. In case you get lost: just ask. Everyone on campus helps at least three lost souls a day find their way. We like to help.
Other than that, gender might offer a clue: an accumulation of men can be found in the eastern part of the uni (science and engineering), of women in the western wing (humanities and medicine). Should anyone happen to venture into the respectively other part, you know what he/she is probably up to.
Tinder was thus declared superfluous and abolished at the Ruhr-University Bochum.
Instead, after – Attention! – two decades of scent research, this ongoing courtship dance of young people has spawned the world's first uni perfume, 'Knowledge'. I am still strongly convinced that the buildings' significant asbestos and PCB pollution is in no way related to certain research output…
In addition to the theater and the uni, the republic's finest soccer stadium is the third architectural gem in Bochum, that's for sure. Understandably, people who are not as well-versed in the pettiness of the second division usually ask 'Ahm, so the VfL Bochum ranks where in the standings?'
Typically, the fan then hems and haws, mumbling something like 'difficult season' and 'lots of cheating'. But, right now, the ignorant inquirer will get an enthusiastic
'Front-runner, front-runner, hey, hey!'.
Problem: the club doesn't have any money to buy players. So, we either take the ones nobody else wants, or we hatch our own. Once they're really good, we sell them so we can buy new jerseys for the remaining players.
The evil capitalism of soccer prevents us from playing good soccer. Every two weeks, we drown our sorrows in the world's best beer (Fiege, of course) and fervently sing in the East Curve
'Here, where the heart still counts,
not the big bucks!'
* * *
Early in 2006, the headline of the British newspaper The Economist already read "If you seek paradise, go to Jena". In Germany, however, people aren't so sure about that. Wrongly so, thinks Ariane Kovac.
Da ist in der Erziehung offensichtlich vieles richtig gelaufen, liebe Tochter! Seit Deiner Geburt habe ich keine Gelegenheit ausgelassen, Deine Geburtsstadt bei Dir gefühlsmäßig zu implantieren. Selbst der frühe Wegzug – Du warst nicht einmal drei Jahre alt – in das Vor-Sauerland hat nicht nachhaltig geschadet. Du hast nach mehreren Stationen im In- und Ausland spät, aber nicht zu spät, den Weg an den Startpunkt zurückgefunden. Nur wer Bochum wirklich gerne hat, kann eine solche Hommage schreiben.Vielleicht finden Mechthild und ich auch nochmal den Weg zurück an den Ort, der uns fast vier Jahrzehnte geprägt hat. Wie sagt man bei uns: "Nichts ist unmöööchlich!"
Oh ja, Bochum ist völlig unterschätzt. Ich habe gerne dort gelebt, auch studiert, viel erlebt, das Schauspielhaus genossen (noch unter Zadek und Peymann, was jetzt Rückschlüsse auf mein Alter zulässt), erinnere mich noch an eine sehr beeindruckende Inszenierung von Brechts Johanna, habe GC und Audimax gehasst, im Unicenter eingekauft und das Cinema zur Rocky Horror Picture Show besucht… im Lottental entspannt, im Kemnader See gebadet und bin im Bermuda Dreieck versumpft. Schön wars und eigentlich sollte ich mal wieder zu Besuch kommen!
Herzerwärmend und sehr treffend beschrieben. Habe mich in vielem wiedererkannt. Bin vor 13 Jahren der Liebe wegen nach Ostfriesland "ausgewandert". Allerdings zieht es mich mehrfach im Jahr für Kurztrips immer wieder in meine Heimat zurück. Am schönsten ist für mich der Weihnachtsmarkt. Bochum ist die schönste Stadt der Welt.
Glück auf!
Schöne Zeilen zu meiner alten Heimat! Ich bin nebenan in Herne gross worden, verbrachte aber den grössten Teil meiner Freizeit im benachbartem Bochum ;)
Uganda The Long Road to WaterKongo Crossing CongoSouth Africa: Kruger NP The Big FiveSomalia Welcome to Somalia
USA: Alaska Big RiverNicaragua The Magic of the Corn IslandsUSA: Alaska Alone in the WildernessUSA: Colorado Rocky Mountain High
Antarctic Happy Antarctica
Kirgisistan Die Flügel des MenschenRussland Couchsurfing in RussiaThailand Der Pfad der ErleuchtungAfghanistan KabulChina K2Pakistan Hitchhiking Through Pakistan On the Road of LifePhilippinen Me, Love and Other CatastrophesIran Kids of TehranBangladesh Life and Death in the Empire of the TigerIran Couchsurfing in IranBurma Road to MandalayVietnam Lost in Vietnam
Germany Towards WinterGermany Das blaue ParadiesSchweiz Zur grünen StundeNorwegen The Rest is Silence Germany ZauberlandSpanien Mrs. Müller Drops OutNorwegen Ultimate FreedomSpanien Into the Heart of the PyreneesFinnland Wandering CosmosGermany The Bundesliga village Germany Under The DomePoland Warszawa rzucająca na kolana On the Road of LifeGermany Munich: Oh well, I live here. So?Germany Jena: Next Stop ParadiseGermany Bochum: Steel HeartbeatsTürkei Arrival in Istanbul Italy Dear Dolomites, I'm BackTürkei Floodlights in the ForestCroatia Ambuscade at the BorderGermany The Bavarian OlympicsAustria Across (Goat) CountryLatvia Somewhere up thereGermany The Big GoalGermany My Loveletter to LangeoogGermany The End of a Journey
New Zealand Speed Dating with New Zealand
Welt Six Pairs of Shoes
Russland Couchsurfing in RussiaGermany Das blaue ParadiesSchweiz Zur grünen StundeNicaragua The Magic of the Corn IslandsKongo Crossing CongoNorwegen Ultimate FreedomSpanien Into the Heart of the Pyrenees On the Road of LifePhilippinen Me, Love and Other CatastrophesTürkei Arrival in Istanbul Türkei Floodlights in the ForestCroatia Ambuscade at the BorderAustria Across (Goat) CountryGermany The Big GoalNew Zealand Speed Dating with New ZealandAntarctic Happy AntarcticaBurma Road to MandalayVietnam Lost in Vietnam
USA: Alaska Big RiverUganda The Long Road to WaterAfghanistan KabulNorwegen The Rest is Silence Germany Under The DomeChina K2USA: Alaska Alone in the WildernessPakistan Hitchhiking Through PakistanIran Kids of TehranUSA: Colorado Rocky Mountain HighBangladesh Life and Death in the Empire of the TigerIran Couchsurfing in IranSomalia Welcome to Somalia
Germany Towards WinterKirgisistan Die Flügel des MenschenThailand Der Pfad der ErleuchtungWelt Six Pairs of ShoesGermany ZauberlandSpanien Mrs. Müller Drops OutFinnland Wandering CosmosGermany The Bundesliga village Poland Warszawa rzucająca na kolanaGermany Munich: Oh well, I live here. So?Germany Jena: Next Stop ParadiseGermany Bochum: Steel HeartbeatsItaly Dear Dolomites, I'm BackGermany The Bavarian OlympicsLatvia Somewhere up thereSouth Africa: Kruger NP The Big FiveGermany My Loveletter to LangeoogGermany The End of a Journey


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Daily Dose of Grammar
The Grammar Devotional, the latest book by Mignon Fogarty (AKA Grammar Girl), is a helpful tool for learning grammar painlessly.Read More
Learn About Ebooks at PodCampAZ
Let me whet your appetite for my PodCampAZ session all about using ebooks to give your business superhero powers. It's Saturday, November 14, 2009 in Tempe, AZ.Read More
Visit Twitter School
Are you looking for information to help you begin using Twitter or master its features for your business? Then look no further. Twitter School is in session.Read More
Twitter School
No matter how much or how little experience you have with Twitter, here are some blog posts and ebooks to help you move to the next level.Read More
Multiple (Twitter) Personalities
Are you considering multiple Twitter accounts? Or do you have multiple account and find it a challenge? Here's some practical advice.Read More
Twooting: Twitter & Text Messages
Watch today's Twooting podcast with video shot live in the studio. I'm interviewed and we talk about using Twitter with text messages.Read More
Twooting It Up!
See and hear my interview on the Twooting.com podcast today where I talk about my recent blog post, Twitter New User Checklist.Read More
Twitter New User Checklist
If you are new to Twitter or are considering joining, review my list of ten common mistakes made by new users so you can have the best experience possible from the start.Read More
Tell Me A (Back)Story
If you create content, you have backstory that you can also share with your audience. Use the backstory as content to build personal relationships and customer loyalty.Read More


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While many marvelled at the novelty of a new £1 coin last week, pier bosses have been reminding the public of the burden it has
Gala's commercial director Andy Goram explains how multiplayer community games compliment the company's bingo offering to help foster a 'friendly, social gaming environment'. How
The Irish Gaming Show, which took place between 7th and 8th March, was a key success for GeWeTe with local operators in the region's market.
TouchTunes' Nick Hardy highlights how Playdium smart jukebox forecasts are ahead of pre-launch figures. On the back of what he described as a 'hugely positive and
Brigid Simmonds, Chief Executive for the BBPA, has responded to Theresa May's Brexit speech welcoming the PM's focus on business tax rates. The BBPA's
The story of Britain's inbound tourism industry is a confused one, with different bodies indicating conflicting trends for the leisure industry in 2017. The recently
Members of the industry interested in sharing knowledge with their American and worldwide colleagues in the FEC sector may enjoy a trip to Georgia for
Contactless transactions in the UK rose by 166 percent during 2016, according to the latest Barclaycard Contactless Spending Index. Almost half of all eligible transactions
In September, Merlin warned of lay offs at its flagship Alton Towers and a decline in revenue of over 10 percent. However, having weathered the
Manufacturers of Category C gaming machines have been urged to develop more products that target the millennial generation. The call came from James Sharpe, national


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APEX Plugin – Ext.tree.TreePanel (RC1 Release)
I'm very proud to announce the first public release of a new commercial APEX plugin based on the tree widget from the Ext JS library developed by Sencha. It's jam-packed full of functionality and customisation ability. It's simple to use with predefined defaults "Out of the Box", but also allows you to use every config parameter, method, and event documented in the Ext JS API.
Here's a list of the plugin's features:
- AJAX enabled with the choice of loading the entire tree in one call or on node by node or X many levels expanding ability
- Search: Dynamic filtering of the tree contents
- Customisable Expand & Collapse & Refresh buttons
- Tree drill down capability
- Drag & Drop Reordering Support
- Tree Label Editing
- Checkbox Nodes with state saving using an existing APEX item
- Context Menu with complex object Support (from a single SQL Query)
- Cookie based state saving for expanded nodes.
- Order by "Display Sequence" support
- Fully integrated into dynamic actions. Bind click, drag & drop, edit complete, expand, collapse, context menu selection etc. events
- In it's basic form opens URL targets
- Tree config is fully customizable with application level defaults
- Support for node by node custom config, e.g. enableDrag = false
- Full support for replacing substitution strings in both config & data
- Custom icon support
- Help Text/Quick Tip support
- Supports unlimited tree's on a single page
- Theme changing support
and here's where you can find the documentation, demo's, and download.
I'm hoping to get some feedback and enhancement requests over the next few weeks before releasing the final production version towards the end of May. One point to note: it does require the purchase of a plugin license and that you also hold/purchase a license from Sencha to use the Ext JS library; but before this changes your mind you may want to consider the following:
- It's simple to use. All you need to define is a simple flat SQL query, no CONNECT BY needed.
- It will save you time every single time. You can create an AJAX enabled tree with context menu support in a couple of minutes. It's arguably the fastest way to create a complex Ext JS tree end to end, thanks to the RAD architecture of APEX.
- With AJAX node by node expanding capability you can create a tree based on large datasets, it's been tested on 20,000+ record hierarchical tree's.
- It provides feature rich options not available in the standard APEX jsTree. Such as checkboxes, label editing, drag & drop reordering, AJAX fetching by X many levels, searching, the list goes on… all within the one plugin.
- It's integrated into Dynamic Actions, which means it's easy to bind events and actions within the actual APEX framework/IDE. Refreshing standard APEX reports via AJAX on different tree events is simple.
- It's fully supported, will stay actively developed, and you can file enhancement requests.
- Once you choose Ext JS you're opening up endless of possibilities for developing feature rich applications, whilst safely knowing you can still use standard APEX components and jQuery. It's the best of both worlds!
- Ext JS provides cross browser support, it's built on Web Standards, which translates into reduced maintenance & troubleshooting.
- This is the first of many plugins in the pipeline. The license revenue will fund future plugin development, so your support is essential. I'm passionate about bringing as much Ext functionality to APEX as possible in a future proof, maintainable approach so "we all" can build amazing web applications, amazingly fast.
Test it out, I'm positive you won't be disappointed….. and if you are let me know, I want your feedback good or bad.


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This practice doesn't provide this information.
I would definitely recomend Dr. Inglis. She made it a pleasure to visit the dentist
If I can help it I will never use another dentist again. I was terrified but this dentist is excellent! no pain at all and very patient
This Practitioner has not published any rates.


text: Must see brewery with excellent beer, great food, and killer atmosphere! We are regulars! The brewery is off the beaten path, but easy to find. The Out of Order ipa is one of my favs, as well as the Cream Ale and seasonal pumpkin. Thursday night weekly trivia and live music on some weekends! Biker garage theme!!


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Chairman of the Board of Aquaporin A/S
Søren Bjørn Hansen
M.Sc. (Economics), Chief Investment Officer of M. Goldschmidt Holding A/S. Chairman of the Board of Aquaporin Asia Pte. Ltd., Chairman of the Board of Danish Aerospace Company ApS, Chairman of the Board of erik bagger a/s, Chairman of the Board of Golgi ApS, Deputy Chairman of the Board of Imerco Holding A/S.
Deputy Chairman of the Board of Aquaporin A/S
Niels Heering
Partner at Gorrissen Federspiel. Chairman of the boards of NTR Holding A/S, Civ.ing.N.T.Rasmussens Fond, Ellos Denmark A/S, Helgstrand Dressage A/S, Nesdu A/S, Henning Stæhr A/S, M. Goldschmidt Holding A/S, M. Goldschmidt Capital A/S, M. Goldschmidt Ejendomme A/S, MGE Bolig Hillerød Holding A/S and Imerco A/S. Deputy Chaiman of the boards of J. Lauritzen A/S and 15. juni Fonden. Member of the Boards of Scandinavian Private Equity A/S, Ole Mathiesen A/S and Lise og Valdemar Kählers Familiefond.
Member of the Board of Aquaporin A/S
Jens Lage Hansen
Started Aquaporin A/S with the CEO in 2005, Deputy Chairman of Aquaporin Asia Pte. Ltd., co-founder and Chairman Intomics A/S. Formerly, an international career in marketing, general management and board representations at Novo Nordisk A/S, Novozymes A/S, Foss A/S, Danisco A/S and Grundfos A/S. Core competences are business strategy and general management
Member of the Board of Aquaporin A/S
Michael Frank
Responsible for the portfolio and investment company of Syddansk Innovation A/S. Formerly Chief Financial Adviser and Analyst with a history in several foreign investment companies. Offers a strong financial network into the Nordic capital and venture market.
Member of the Board of Aquaporin A/S
Cai Jianwen
President of Interchina Water Treatment HK Co., Ltd. Formerly, CFO of Interchina Water. Mr. Cai Jianwen previously worked in in Vanke, Johnson Control and Deloitte.
Member of the Board of Aquaporin A/S
Lei Zhang
Master of law, Peking University & Université Paris I – Panthéon-Sorbonne, National Legal Profession Qualification of P.R.China. Director of the Board, Senior Vice President of Poten Environment Group Co., Ltd., CEO of Poten Environment Group (HK) Limited. Formerly legal counsel at French law firm Gide Loyrette Nouel.
Member of the Board of Aquaporin A/S
Lars Hansen
CEO of the Villum Foundation. Formerly with Danish Biotech company Novozymes as Corporate Vice President in various functions and with regional responsibilities in North America and across Asia.
Member of the Board of Aquaporin A/S
Torsten Freltoft
CEO of Freltec ApS. Former Chief Executive Officer and co-founder of Sophion Bioscience, a leading provider of automated patch clamp screening systems for the pharmaceutical industry. Former Deputy Director of NKT Research. Besides a long industrial experience, Torsten Freltoft has a strong scientific background – amongst others in numerous biotech start-ups.
Member of the Board of Aquaporin A/S
Daniel Goldschmidt
Founder and CEO of DG Invest. Member of the boards of M. Goldschmidt Holding, Danish Aerospace Company, Danish Aerospace Medical Company, Aquaporin Space Alliance, Imerco Holding and Imerco A/S.


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This is the place to post that hilarious irreligious YouTube video, an irreverent, anti-religious cartoon, or other humorous bit of media. Posts that do not reflect an atheist/irreligious theme will be deleted. (Don't make me go Old Testament.)
Members: 2103
Latest Activity: yesterday
A slightly longer version of the clip that used to be here.
Started by Loren Miller. Last reply by Grinning Cat Aug 6, 2016. 21 Replies 6 Likes
Started by Gary Canup. Last reply by Joseph P Sep 29, 2015. 7 Replies 1 Like
Spud, that is great. The Wile E. Coyote was done by Seth McFarland. And, is fantastic.
An unemployed Wile E. Coyote. It went right to the heart of existential angst. Chortle.
Watch to the end.
Spud, I LOVE it! Thanks!
Great cartoons to start off a morning. Thanks for the laughs Bertold and Patricia,
Oh - Maybe it's not in the snow, but the mud!
I cook tortillas every day. I keep looking for Hitch's image, but so far, no dice. I guess my non faith is not strong enough.
© 2017 Atheist Nexus. All rights reserved. Admin: Richard Haynes. Powered by


text:
Re: [ksurfschool] land practice?great idea!!!!
Expand Messages
- hey there,
Its how I learned b4 getting in the water...
I think that on land you have only the kite to worry about and this allows
you to concentrate on kite-control without the added burden of hazards,
water and boards....It also gives you a good feel for the power window...
Remember that on land you are"glued down" so to speak and so it gets way
tiring, way fast. Once you break that friction , either body dragging or
boarding you are flowing with the force and it will take substantially
less effort to "hold on".
Anyway...have fun but BE SAFE......(-:
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Send instant messages & get email alerts with Yahoo! Messenger.
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text: New year, new season. Going to fire up the thread to see what everyone else is up to. My Blood Bowl box came in today, so I'll have that spiffy new jersey on my next team. I've made a couple of teams and I'm not sure which I want to focus on this season. Anyone noticing trends this season? I know a lot of Nurgle showed up last season. I was contemplating grinding a human team, but I'm not sure I could hang at higher TV's with them, Norse are in the same boat. Lizards maybe? I'll figure it out on my next day off. See a lot of the more experienced coaches already have Dark Elves up and running, could be a B**tard and roll some Dwarves . I do have one serious question to ask: Have they changed the ranking formula at all, or does it appear to be the same as season II?


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Published byIsaias Mentor Modified over 2 years ago
AHRQ Annual Conference Patient-Reported Outcomes for Adverse Event Monitoring in Clinical Research Ethan Basch, M.D., M.Sc. Memorial Sloan-Kettering Cancer Center September 28, 2010 No Financial Disclosures
Essential activity in Clinical Research To ensure patient safety To provide data about drug effects –Trialists, regulators, payors, clinicians, patients Core activity in routine care To guide therapy and supportive care Adverse Event Monitoring
Data Sources Differ By Type of AE CATEGORYEXAMPLEDATA SOURCE Laboratory valueAnemiaLab report Clinical observation/measurementRetinal tearClinical staff SymptomNauseaClinical staff vs. patients
Basch: NEJM, 2010 Nausea Fatigue Months Anorexia Vomiting DiarrheaConstipation Months Patient- reported Clinician- reported Clinicians systematically downgrade symptoms compared with patients
Patient adverse symptom reports better correlate with functional status than clinician reports Basch: JNCI, 2009
N=393 Seen by 1 st clinician in office, then 2 nd clinician ~15 minutes later Atkinson: SBM, 2010 Clinician Adverse Symptom Reporting is Unreliable
Patient Experiences Symptom Clinician Interprets Symptom Clinician interviews patient at visit Chart Representation of Symptom Clinician writes in chart Data Manager Interpretation of Symptom Data manager Abstracts chart, converts findings to standardized terminology Research Database Manual data entry Current Model for Adverse Symptom Reporting in Clinical Trials
Patient Experiences Symptom Research Database Patient direct reporting of symptoms
Patient Experiences Symptom Research Database Clinician Patient direct reporting of symptoms
Web-based Handheld devices IVRS Paper Text messaging Interviewer Mixed methods/modes catering to patients Available Technologies
Patient Experiences Symptom Research Database Clinician Patient direct reporting of symptoms Assign attribution; initiate expedited reporting
Patient Experiences Symptom Research Database Clinician Assign attribution; initiate expedited reporting Enhance clinical care Patient direct reporting of symptoms
Patient Self-Reporting is Already Standard in Closely-Related Areas HRQL and symptom efficacy endpoints in cooperative group trials Gold standard for symptom endpoints in drug applications and labeling claims submitted to FDA http://www.fda.gov/downloads/ Drugs/GuidanceComplianceR egulatoryInformation/Guidance s/UCM193282.pdfz
Criticisms of Patient-Reported AEs Not feasible –Patients not willing or able to report –Missing data when patients become ill –Too logistically cumbersome/expensive Will generate "noise" –Patients will broadly endorse symptoms if asked, making it impossible to distinguish AEs between study arms –Will not be helpful in unmasking serious or unexpected AEs
Feasibility High rates of adherence in multi-center industry trials for patient-reported symptoms (IVRS) Meacham & Wenzel (Perceptive Informatics/ClinPhone): ISPOR, 2008
Feasibility Little attrition over time (web-based) –Including non-web avid, elderly, end-stage with high symptom burdens Basch: JCO, 2005; 2007 Velikova: JCO, 2002 Farnell: Eur J Cancer, 2010
PROs Can Distinguish between Study Arms and Identify Serious AEs NCCTG 9741: Phase III trial comparing three chemotherapy regimens for metastatic colorectal cancer Closed after 841/1,125 patients enrolled due to unexpected excess of early deaths in Arm 1 ("IFL") –Associated with "GI syndrome" including severe diarrhea Diarrhea reporting: –Clinicians reported toxicities at each cycle (diarrhea required) –Patients reported diarrhea via in HRQL (SDS) every other cycle Rothenberg: JCO, 2001
Clinician-Reported Diarrhea Dueck: Unpublished Data, 2010
Patient-Reported Diarrhea Dueck: Unpublished Data, 2010
Patient vs. Clinician Diarrhea in Arm 1 (IFL) Dueck: Unpublished Data, 2010
Adverse Symptoms Are Common Indication # of U.S. Approved Drug Labels Average # of AEs per Label Total # of Unique AEs across Labels Proportion of AEs which Are Symptoms Breast Cancer 3278616 36% (223/616) Asthma 3554368 49% (180/368) GERD 18115472 45% (213/472) Hyperlipidemia 2882365 43% (158/365) Osteoarthritis 3994684 41% (278/684) Many adverse reactions in drug labels are symptoms
Docetaxel Drug Label
Development of the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) Initiated October 2008 NCI Contract HHSN261200800043C
Mission Develop a system for patient electronic self-reporting of adverse symptoms in cancer trials, which is widely accepted and used; generates useful data for investigators, regulators, clinicians and patients; and is compatible with existing adverse event reporting software systems
PRO-CTCAE Network NCI ADVISORS TECHTECH NETWORKNETWORK NCCCPNCCCP MSKCC Coordinating Center Dana-Farber MD Anderson Mayo Duke Penn FDA Cooperative Groups Industry Christiana Hartford OLOL Spartanburg St. Joseph - Orange SemanticBits Perceptive Patient Advocates DCPDCCPSDCTD CBIIT
Item Development Evaluated the standard lexicon for adverse event reporting in oncology (CTCAE) –Currently reported by clinicians Of 790 CTCAE items, 81 are amenable to patient self-reporting ("symptoms") –To create patient versions of these items, generic question structures were developed based on existing questionnaires Removed medical jargon Attention to cultural literacy
Example: Mucositis CTCAE v4 TermGrade 1Grade 2Grade 3Grade 4 Mucositis oral Asymptomatic or mild symptoms; intervention not indicated Moderate pain; not interfering with oral intake; modified diet indicated Severe pain; interfering with oral intake Life-threatening consequences; urgent intervention indicated Two PRO-CTCAE v1 ItemsResponses What was the severity of your MOUTH OR THROAT SORES at their worst? None Mild Moderate Severe Very Severe How much did MOUTH OR THROAT SORES interfere with your usual activities? Not at all A little bit Somewhat Quite a bit Very much
Item Refinement Multicenter "cognitive interviewing" study to assure comprehension across diverse patient populations National "validation" study underway to evaluate measurement properties of items Hay: ASCO, 2010 Dueck: ASCO, 2010
Software Platform
Survey 729 Stakeholders in Cooperative Groups QUESTIONAGREENEUTRALDISAGREE Systems to collect PROs in trials should be developed89%5%6% In trials, adverse events should be reported by patients88%8%4% POTENTIAL BARRIERSAGREENEUTRALDISAGREE Lack of computers69%15%16% Limited personnel57%18%25% SOLUTIONS TO OVERCOME BARRIERSAGREENEUTRALDISAGREE Funding (for personnel, dedicated space, training)79%13%8% Computers72%21%7% Bruner et al: ISOQOL, 2010
Electronic patient-reporting of adverse symptoms in clinical trials is feasible and clinically valuable –Improve quality and efficiency of safety data collection –Enhance understanding of patient experience with treatment –Alert investigators and clinicians to issues meriting attention Appropriate for multiple contexts –Preapproval clinical trials –Postmarket surveillance –Comparative effectiveness research –Clinical practice Ongoing efforts to operationalize and pilot systems Conclusions
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Dr. James Hansen, the former director of NASA and one of the country's top climate scientists, has issued a stern warning for both the United States and the rest of the world: We aren't doing nearly enough to combat the effects of climate change, and the solutions to the problem could now be far too costly to fully negate global warming. The Ring of Fire's Farron Cousins discusses this.
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