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Expert Service 1-661-257-9993 [Hours]
Crunch V1800 V-Drive V-1800
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They are designed to deliver big power on demand, V Drive offers incredible performance in a very sweet visual design including illuminated VU's monitoring power output, a nice mesh grille ventilation system to keep your system running cool, and very killer chrome finishing to top it off. Performance is earth shattering. These great fully bridgeable class A/B amplifiers come in a variety of power configurations including two, four, and mono channel designs.
The Crunch V-Drive amplifiers combine "state of the art" technology with revolutionary design parameters. You expect your amplifiers to sound awesome and look awesome, and these do. Our design is a culmination of sonic purity and industrial design; they're built for the road.
- 1 ohm stable Monoblock Subwoofer Amp
- RMS Power Output at 1 ohm: 1 x 1200 Watts
- RMS Power Output at 2 ohm: 1 x 800 Watts
- RMS Power Output at 4 ohm: 1 x 500 Watts
- Low pass adjustable crossover
- Subsonic filter
- Bass Boost: 0 - 12dB
- Separate bass and treble controls
- Thermal, overload and short-circuit protection
- Gold plated RCA Input/Outputs
- V-Drive Blue Anodized Inverted Heat Sink Design
- VU Metering System for power monitoring (Acrylic Lens for improved cosmetics)
- Mesh-Grille Ventilation Design
- Chrome Heat Sink Cover for sharp looks
- PWM Mosfet Power Supplys
- Fully Bridgeable Design quality
- Blue Very High Quality PCB Design
- Ultra - Drive High Speed Mosfet Output Devices
- On Board Tru Spec Capacitors
- Premium Hand Wound Torroid
- Dimensions: 16 1/2" L x 10 1/3" W x 2" H
- Fuse Rating: 4 x 40 amps (160 amps total)
- 1-year SonicElectronix.com warranty
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Warning: The image depicted shows the resistance change when wiring multiple subwoofer terminals. Please refer to your subwoofer's owner's manual for the proper wiring of its terminals. Sonic Electronix, Inc. is not responsible for damage caused to your audio system or vehicle due to improper installation. Please call tech support at 1-877-289-7664 if you require additional assistance.
Product Name: Crunch V1800 V-Drive V-1800
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Hi! This is my first aarmau story. hope you enjoy.
ToxicEclispe Dec 01, 2016
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subset: commoncrawl


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At any rate, no one here could confirm whether or not Kyran Bracken was about to step into Carling's shoes, least of all the scrum-half himself, who was keeping tight-lipped. Watch this space, as they say, though the hard news concerning Bracken was that he has given up the day job - legal training, that is - so you read what you like into that.
On the pitch, meanwhile, it was Bracken who reminded Carling of his presence with some fine support play as Bristol enjoyed fun in the sun after David Pears had missed a penalty attempt from 40 yards out. Too much chat from Quins and quick thinking by Bristol resulted in a lesson for the visitors and joy for the locals.
Having been marched back 10 yards by Daniel Gillett, a French referee who obviously had an ear for an English curse or two, Quins failed to contain a Bristol tap penalty move started on the right. Dean Wring made ground and, after Nick Smith and Ian Patten had played support roles, Bracken picked up and dived over on the left.
Bristol continued to pick up the points as Mark Tainton, looking over his shoulder now that Arwel Thomas has joined Bristol from Neath, converted Bracken's try and then landed a penalty.
The Quins answer followed a line-out, a big hole opening up in the middle of the Bristol defence and Daren O'Leary making good his escape to score on the left. Tainton and Pears next swapped penalties, which left Bristol to go into the break leading by 13-8.
Yet Carling and company had the last laugh, Carling in every sense, in a nail-biting finish once Will Greenwood and Martin Corry had had their tries converted. Two penalties from Pears and a Spencer Bromley try after Carling's long break put Quins 26-20 ahead.
Paul Hull, though, somehow weaved a path to the line and while there were groans when Tainton missed the conversion, it mattered little in the end. An interception try from O'Leary preserved Quins' all-conquering record.
Bristol: P Hull (capt); K Maggs, N Smith, D Wring, J Keyter; M Tainton, K Bracken; A Sharp, M Regan, D Hinkins, S Shaw, G Archer, R Armstrong, M Corry, I Patten.
Harlequins: J Staples; D O'Leary, W Carling, W Greenwood, S Bromley; D Pears, R Kitchin (capt); S Brown, B Moore, A Mullins, A Snow, P Thresher, M Russell, C Sheasby, R Jenkins.
Referee: D Gillett (France).
- More about:
- Bristol (england)
- Harlequin FC
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Under Armour CoolSwitch Thermocline Shirt for Men
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Trust modern Under Armour® performance and technology to keep you comfortable on your outdoors adventures this summer with the CoolSwitch Thermocline Shirt for Men. Lightweight 6.5 oz. polyester/elastane fabric features a 4-way stretch fabrication to give you greater mobility. Exclusive CoolSwitch coating on the inside of the shirt pulls heat away from your skin to help you feel cooler as temperatures rise, while the shirt's mesh underarm panels provide strategic ventilation. UA's Moisture Transport System wicks sweat and dries fast for greater comfort, while anti-odor technology prevents the growth of odor-causing microbes. Loose cut design for complete, non-restrictive comfort. Under Armour Fish Hook logo across the chest. Machine wash. Imported.
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1. Batman
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Global Debt Exploding, but G8 Leaders Fiddle with the Internet
With Europe facing a massive fiscal mess and the United States buried under $14.3 trillion in debt, one might think that the leaders of the world's eight major economies would get down to business to talk government overspending.
But as Heritage's Jim Roberts writes in The Christian Science Monitor, President Barack Obama and G8 leaders are meeting in France to discuss, among other things, proposed global regulations for the Internet. But debt won't be served up as a topic of conversation on the G8′s table, even though it's a major problem in the U.S. and Europe
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The lawsuit was filed by six plaintiffs led by Hempstead Village Trustee Donald Ryan.
Tagged with: downtown revitalization Hempstead IDA Renaissance Downtowns Village of HempsteadRead More »
January 27, 2017 1 Comment
The lawsuit was filed by six plaintiffs led by Hempstead Village Trustee Donald Ryan.
Tagged with: downtown revitalization Hempstead IDA Renaissance Downtowns Village of HempsteadRead More »
January 10, 2017 Comments Off on Huntington Station gets infrastructure funds
The $1.25 million funding from Suffolk County is for infrastructure design plans.
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December 20, 2016 Comments Off on Town transfers site to start Huntington Station reboot
The first project is a mixed-use building with 16 apartments over 6,500 square feet of retail space.
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December 13, 2016 Comments Off on Work begins on Hempstead's long-awaited downtown reboot
First project to bring 96 apartments and 5,500 square feet of restaurants and retail shops.
Tagged with: Renaissance Downtowns RXR Realty UrbanAmerica Village of HempsteadRead More »
March 26, 2015 1 Comment
An expert in selecting sites for companies says Long Island must find ways to attract and retain its talented workforce to stay competitive with other regions.
Tagged with: Association for a Better Long Island Long Island Long Island Builders Institute Melville Renaissance DowntownsRead More »
January 27, 2015 Comments Off on Arrested development
Builders trade in construction hats for marketing caps to push LI projects to completion
Tagged with: AvalonBay Communities development Hofstra University Long Island NIMBYs Renaissance Downtowns Town of Brookhaven Tritec Real Estate Co. WestburyRead More »
January 15, 2015 Comments Off on Town adopts Huntington Station public benefit plan
The Town of Huntington voted 5-0 to adopt a community benefit agreement with Renaissance Downtowns, master developer for revitalizing Huntington Station.
Tagged with: downtown revitalization Huntington Station Long Island Renaissance Downtowns Town of HuntingtonRead More »
November 12, 2014 1 Comment
An appellate court has upheld a lower court ruling, throwing out a case that could have blocked the redevelopment of property owned by the Village of Hempstead.
Tagged with: Curto Deegan downtown redevelopment Forchelli Harris Beach Mineo & Terrana Renaissance Downtowns SchwartzRead More »
November 7, 2014 Comments Off on Town safety plan could boost Huntington Station renewal
Huntington Station business leaders are optimistic that the Town of Huntington's new public-safety liaison will help promote the area as a downtown destination.
Tagged with: downtown revitalization Huntington Station Renaissance Downtowns Suffolk County Police Town of HuntingtonRead More »
October 8, 2014 Comments Off on Renaissance, RXR to rebuild another downtown
The City of New Rochelle has selected a partnership of Renaissance Downtowns and RXR Realty as master developer for revitalizing its downtown.
Tagged with: downtown revitalization Long Island master developer Renaissance Downtowns RXR RealtyRead More »


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SPRINGFIELD, Mass. – Just how easy did national powerhouse Findlay Prep of Henderson, Nev., make things look out there against Dallas Lincoln?
As the final seconds of the third quarter ticked off in this Hoophall Classic matchup, Texas-bound point guard Myck Kabongo scooped up a loose ball and cut 45 degrees from the top of the key as he effortlessly lobbed up an underhanded alley-oop pass, which teammate Amir Garrett slammed easily as the buzzer sounded, finishing off an 18-6 run and giving the Pilots a comfortable 53-37 lead.
It was that kind of afternoon. Lincoln, ESPN Dallas' No. 2 Class 4A squad, boasts two of the state's elite forwards in seniors LeBryan Nash and Keaton Miles. But where the Tigers matched up favorably in the frontcourt, they struggled to match the speed to hang with the Pilots' rapid tempo for 32 minutes, as they fell 68-59 at Springfield College's Blake Arena.
"They played aggressive man (to man)," Nash said. "They've got a lot of kids from AAU. They're like an AAU team, and we weren't ready for them. We thought we could come in here and just play our game. We thought we could just walk away with a win."
Meanwhile, head coach Leonard Bishop was finding silver linings in the loss, which was televised nationally on ESPNU.
"They did a great job. I think we had a great game plan for them, and I think the only thing that hurt us was that we didn't run our offense a couple times, and they scored," Bishop said. "We knew they were going to be tough, and hard to beat, but we're pleased with the guys. I'm not satisfied, because of the third quarter, but overall I thought they played well."
Nash, an Oklahoma State recruit and the No. 12 player in the Class of 2011 in ESPN's latest rankings, did his part (23 points, eight rebounds). So did Miles, who racked up a double-double (15 points, 13 rebounds) and provided some early defensive spark in the paint. But while the Tigers excelled in the half-court, going toe to toe with bigs Garrett and Winston Shepard (16 points, 13 rebounds) and trailing 35-31 in the break, they stumbled once the Pilots turned up the pressure in the third quarter.
With Kabongo (14 points, 10 assists) leading the press, the Pilots forced the decision-making into the hands of the backcourt and used the suffocating pressure to create a series of easy transition baskets for high-flying Arizona recruit Nick Johnson (19 points).
Overall, Nash and Miles combined for 12 of the Tigers' 17 turnovers. So while the Pilots played just seven, one got the feeling these guys could run all night at that pace.
"That was one of the points of emphasis at halftime," Findlay head coach Michael Peck said. "We've got to come out, and instead of letting them walk the ball up the floor and initiate offense in a rested position, let them burn a little bit of that 30-second shot clock, so they're a little bit more scrambled and a little bit more hurried and rushed.
"And also, let's make conditioning a factor, because we think we have an edge there, so that's what we did in the second half. And over the course of time, I think it took its toll on them a little bit, and we were able to capitalize."


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Even the approach to the Finstertaler Scharte (2779 m) is a very satisfying day tour and the few meters of altitude to the Schartenkogel are easy for anyone. If the weather is good, the somewhat isolated Kraspesspitze is to be recommended – it gives one a good impression of the isolatedness, far from the "big trails" – and it shouldn't be forgotten that this is the third highest summit in the selection of marked Kühtai summit destinations. Follow, as on the second day, Trail No. 146 to the left, at first in steep hairpins over the uppermost grassy slope. A last beautiful mountain meadow at the foot of the cirque beckons one to enjoy a panoramic rest stop and listen to the bubbling of the brook. The very good markings now lead to the sunny eastern flank of a partly green rock spur. Two terraces on the slope in the far reaching cirque basin surprise the hiker with their crystal clear, tiny lakes created by melting mountain waters. In the middle of the otherwise unproblematic ascent, a steeper, extremely shady north face passage, with ice fragments or hard snow, may be somewhat unpleasant.But then comes the wide, flat saddle (2779 m), from which point Trail No. 146 winds down through the large cirque to the Guben Schweinfurter Hut. Perfect markings attract one to the only 75 meters higher Schartenkogel, which one reaches without any problem over a block ridge. Especially impressive is the view to the Sulzkogel from here, where you can see the entire ascent of yesterday.The Kraspesspitze is quite a bit longer and more complicated to climb. It should only be attempted in good weather, due to the sparse markings. The path leads just a few steps beyond the saddle eastwards and then descends towards the south beneath the ridge. After a short, flat traverse, one climbs through very steep switchback turns over a grassy ridge and on over rockfields and scree cirques until just beneath the scree pyramid of the summit. Here there is a well-marked variant of the Gubener trail leading right to the summit. The final segment of the trail to the summit cross is clearly marked.To the north, you see the reservoir and the approach route, especially instructive is the view down to Haggen over the Kraspesferner glacier and of course the wide silhouette of the nearby Zwieselbacher Rosskogel, which is inaccessible from here. Your gaze sweeps over the Horlachtal towards the icy giants to the south.Altitude difference: Sulzkogel 1000 meters, Kraspesspitze from Finstertaler Scharte, an additional 180 meters.Time: Sulzkogel 4 hours ascent, with Kraspesspitze and additional 2 1/2 hours.Back to list


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I'm not going to lie to you, I've been toying with the idea of writing a post like this for a while but I've never had the confidence. It is thanks to you and the kind, genuine comments I received on my Big Fat Truth post that I've been able to do this. Sandra of The Black Pearl Blog in conjunction with moneysupermarket.com and their Get Fit Feel Epic competition swayed me when I saw the great giveaway for blogging about this. There's nothing like an incentive when it comes to fighting insecurities.
As I've mentioned before I have been overweight for as long as I can remember. Being a UK 18-20 can be difficult but it's not my size that bothers me as much as how awful I feel. Most of this can be attributed to the fact that I have a condition called Fibromyalgia which affects the muscles causing chronic pain and fatigue among other things but I can't shy away from the fact that my weight contributes a huge amount. Pain while dragging yourself around is not helped by being six stone overweight. Due to the fact that gyms are a bad idea for me, I have decided to get fit at home for free doing the amount of exercise I can feasibly do every day. I'd love it if I lost a few inches, of course but the thing I really want to gain from this is to feel healthier.
I've already started and I am slowly losing 1-2 pounds a week. I eat 1500 calories a day including lots of fresh vegetables, less carbohydrates (I haven't cut them all out), less sugar and a serving of fruit. Since I physically can't exercise as much as I would love to I have to keep my calorie intake under control or else it could spiral very quickly from weight stabilisation to gaining weight. I still eat yogurt, eggs, meat etc but I use the whites of eggs instead of the whole thing in an omelette and cut the fat off meat before grilling it in my trusty George Foreman. I'm not saying I haven't wavered and eaten more than 1500 calories or haven't dipped my sticky fingers back into the chocolate drawer for a second helping of snack sized Malteasers but when I do I fully acknowledge that I've slipped and that it's okay. It's just a day and if I don't get results from my new habits I have nobody to blame but myself.
For exercise I use tins of beans as weights and exercise my arms in front of the TV. I walk at least 45 minutes a day to and from school and even if I walk slowly, I am still moving my body and I still count that as exercise. If I am well enough to walk the dog in the evenings I count that as exercise and I log it all in MyFitnessPal. I don't think of the estimated calories I burn as excess calories to eat whatever I want and because I eat big portions of healthy food I find that I rarely get hungry now or go over my calorie limit by more than 100.
My self-confidence is still low. I still wear Spanx, I still cry, I still get hurt when people comment saying I'm fat, ugly and beastly. I'm still not confident enough to do many outfit posts and I'm still learning but this attitude has got me this far. This honesty is what people tell me they enjoy most and if I told you all I'd lost a stone, eat well the entire time, felt completely fabulous about myself since doing X Y and Z I wouldn't be that person anymore. I have to say the first few weeks feel crap. I crave bread, I feel low, I hurt more than usual, I cry about how this is never going to work and how I will always be worthless in everyone's eyes.
They are low points. This blog post was difficult to write and those photos are difficult to share but I hope to feel epic. Maybe not now, maybe not in a month but when I reach my goal of feeling even slightly elated and on the path to epic? I'll let you know.


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This book discusses a case study that researched factors that have impeded English acquisition in twelve Mexican adults. In interviews, participants shared their experiences in trying to learn English and described how they have been able to survive in Anglo communities without knowing much English. Participant observation provided a view of their interactions and of the extent to which they use English in their daily lives. Participants also drew up a free list of factors which would help them learn English. Based on this data, conclusions are drawn about the factors that have prevented these Spanish-speaking adults from learning English.


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Authority Adult Large Breed with Real Chicken
December 6, 2010
Filed under Authority Dog Food, Dog Food Reviews, Latest Dog Food Reviews
This dog food starts out with 3 quality ingredients then quickly nose dives to the bottom of the barrel with the next 4 ingredients. Besides having low quality ingredients it is very grain heavy. Corn Gluten Meal is one of the lowest grade ingredients that can be put in a dog food. We do not recommend this dog food.
Authority Adult Large Breed with Real Chicken Ingredient Analysis
Chicken is a good meat for dogs, but after processing it could lose up to 70% of its mass.
Chicken meal is an excellent ingredient in a dog's food.
Brown rice is a very high grade of grain.
Corn is a terrible ingredient in a dog's food. Corn causes skin, coat, eye and ear issues in most dogs. It also is the cause of allergies in many dogs.
Oat groats are whole, minimally processed oats.
Authority Adult Large Breed with Real Chicken Ingredient List
Chicken, Chicken Meal, (Source of Glucosamine and Chondroitin) Brown Rice, Corn, Oat Groats, Corn Gluten Meal, Dried Beet Pulp, Chicken Fat (Preserved with Mixed Tocopherols), Natural Flavor, Dicalcium Phosphate, Dried Egg Product, Canola Oil, Potassium Chloride, Choline Chloride, Vitamin and Mineral Supplements (Zinc Sulfate, Ferrous Sulfate, Vitamin E Supplement, L-Ascorbyl-2-polyphosphate (source of Ascorbic Acid), Copper Sulfate, Vitamin A Supplement, Manganese Sulfate, Niacin, D Calcium Pantothenate, Vitamin D3 Supplement, Riboflavin, Calcium Iodate, Pyridoxine Hydrochloride, Thiamin Mononitrate, Folic Acid, Sodium Selenite, Biotin, Vitamin B12 Supplement), Dried Chicken Cartilage (Source of Glucosamine and Chondroitin).
Authority Adult Large Breed with Real Chicken Guaranteed Analysis
Guaranteed Analysis describes the nutrient content required by AAFCO labeling standards to be identified on every product package. Since these are guarantees, pet food manufacturers work to formulate diets that meet or exceed the minimum requirements.
|Crude Protein not less than……. 25.0%
Crude Fat not less than…….. 12.0%
Crude Fiber not more than……. 4.0%
Moisture not more than…… 10.0%
Calcium not less than….. 1.1%
Phosphorus not less than…..0.90%
Zinc not less than…..175mg/kg
Selenium not less than …..0.15mg.kg
|Vitamin A not less than …..15,000 IU/kg
Vitamin E not less than….. 225 IU/kg
Omega-6 Fatty Acids not less than….. 2.8%*
Omega-3 Fatty Acids not less than….. .20%*
Glucosamine not less than ….. 400mg/kg*
Chondroitin not less than….. 300mg/kg*
Vitamin C not less than….. 20 mg/kg*
Calorie Content: 3,635 kcal/kg metabolizable energy (calculated)
*Not recognized as an essential nutrient by the AAFCO Dog Food Nutrient Profile.
Authority Adult Large Breed with Real Chicken Recommended Daily Feeding Guidelines
|Dog's Size
|Dog's Weight
|Amount to Feed Per Day
|21-50 lbs
|1 1/2 – 3 cups
|51-90 lbs
|3 – 4 3/4 cups
|90 – 120 lbs
|4 3/4 – 5 3/4 cups
|120+ lbs
|5 3/4 cups +1/3 cup (for every 10 lbs. over 120 lbs.)


text: TechAppleNews Digital Camera Raw Compatibility Update 4.03 released by Apple By Andrew Edney - Dec 17, 2012 Apple has just released a Digital Camera Raw Compatibility update – version 4.03. This update adds RAW image compatibility for a number of cameras to Aperture 3 and iPhoto '11. It's a small download so go update now! RELATED ARTICLESMORE FROM AUTHOR Call of Duty: WWII revealed and yes the Zombies are back!!! Little Nightmares launch trailer revealed Release Date Set for Marvel Vs Capcom: Infinite STAY CONNECTED6,743FansLike9,052FollowersFollow21,005SubscribersSubscribe LATEST REVIEWS Review: The Walking Dead – A New Frontier Episode 4 Sean McCarthy - Apr 25, 2017 Quicker than I had expected and just one week after the launch of Telltale Game's newest series in MARVEL's Guardians of the Galaxy, Episode... Review: Ultimate MARVEL Vs Capcom 3 – Xbox One Apr 25, 2017 Review: Is Huawei back with the P10 after last years P9? Apr 25, 2017 Review: Ghost Recon Wildlands – Narco Road DLC Apr 25, 2017 Review: The Disney Afternoon Collection Apr 21, 2017 Review: MARVEL's Guardians of the Galaxy: A Telltale Series Episode 1 Apr 20, 2017 Review: BT Whole Home Wi-Fi Apr 19, 2017 Review: LEGO Worlds Apr 18, 2017


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I was very happy with the service time was t on time also he and his wife made us very comfortable while taking the photos and being very professional and the price was right i will be recommending him to my friends
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Europe and the United States account for more than 80% of global sales of new medicines, 75% of global R&D in life sciences, and create and sustain over 1.5 million direct jobs.1 The Transatlantic Trade and Investment Partnership (TTIP) could significantly boost the world's largest trading relationship, spur transatlantic investment in life sciences, and foster research cooperation, resulting in improved healthcare and enhanced patient access to innovative medicines on both sides of the Atlantic. TTIP also has the potential to set global standards in key areas.
Despite the potential benefits of this opportunity, questions have been raised about the TTIP, its provisions relating to life sciences, and the role of the pharmaceutical industry. This document aims to address some of the myths, and to highlight the benefits of increased transatlantic cooperation through the TTIP.


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As expected, GM's announced to dealers a limited Chevy Camaro Bumblebee Edition will be available to order beginning June 1st. Production will run from June 24th through December. Expected upgrades will be only what meets the eye — rally yellow coloring, black stripes and Transformers badging inside.
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Adipose derived stem cells (ADSCs) are a somatic stem cell population contained in fat tissue that possess the ability for self-renewal, differentiation into one or more phenotypes and functional regeneration of damaged tissue, which will benefit the recovery of erectile function by using a stem cell based therapy.
To review available evidence concerning adipose derived stem cell availability, differentiation into functional cells, and the potential of these cells for the treatment of erectile dysfunction (ED).
We examined the current data associated with the definition and characterization of adipose derived stem cells, including the differentiation of these cells and the initial effects of adipose derived stem cell therapy in a rat model of erectile dysfunction.
There is strong evidence supporting the concept that ADSCs are a potential stem cell therapy source for treatment of erectile dysfunction.
The adipose derived stem cells are paravascularly localized in the adipose tissue. Under specific induction medium conditions, these cells differentiated into neuron-like cells, smooth muscle cells and endothelium in vitro. The insulin-like growth factor/insulin-like growth factor receptor (IGF/IGFR) pathway participates in neuronal differentiation while the fibroblast growth factor 2 (FGF2) pathway is involved in endothelium differentiation. In addition, the internal ribosomal entry sites (IRES) regulated gene translation is related to these types of differentiation. In a preliminary in-vivo experiment, the adipose derived stem cells functionally recovered the damaged erectile function. Therefore, the underlying mechanism needs be further examined.
The adipose derived stem cells are a potential source of stem cells for treatment of erectile dysfunction, which highlights the possibility of an effective clinical therapy for ED in the near future.
Stem cells (SC) are endowed with the capacity to self-renew and differentiate into various cell types, depending on the stimuli or signals that they receive. While embryonic stem cells (ESC) have greater differentiation potential than adult stem cells (ASC), the former will most likely take years to reach clinical application due to ethical concerns and governmental restrictions associated with its use. Since firstly reported in 1998[1], the human stem cell researches have attracted thousands of scientists worldwide. Actually, the wide range of uses for treatment of multitude of human diseases is the major argument in favor of human stem cell research [2,3].
Adipose-derived stromal cells (ADSCs) [4] have previously been shown to possess stem cell properties such as transdifferentiation and self-renewal. They are a somatic stem cell population contained in fat tissue and posses the properties of self-renewal, differentiation into one or more phenotypes and functional reproduction of damaged tissue [5,6]. ADSCs share the same properties of all stem cells, such as the ability to divide and renew themselves for long periods, and differentiate into specialized cells. Right now, the sources of adipose derived stem cells include three types of adipose tissues, including brown adipose tissue (BAT), white adipose tissue (WAT), and bone marrow adipose tissue.
ADSCs are virtually identical to Bone marrow stem cells (BMSC) in differentiation and therapeutic potential and are much easier and safer to obtain in large quantities. ADSCs therefore appear to be a better choice for future clinical application within the stem cell field[7]. Meanwhile, the ADSCs have many advantages compared to BMSCs, including the ability to isolate many more stem cells using a minimally invasive surgical procedure for extraction of the adipose tissue. Although the isolation and characterization of ADSCs have been well documented, the in-situ localization of ADSCs in BAT / WAT is poorly understood. By applying an extensive scan of the stem cell markers with immunohistology, it was shown that CD34+ cells, the well described progenitor/stem cell in adipose tissue, were clearly localized perivascularly [8]. Also, the isolated and purified ADSCs have successfully differentiated into neuron-like cells, smooth muscle cells, and endothelium in vitro [9–11].
In recent years, there has been much interest surrounding adipose derived stem cells, but the ADSCs field of research has actually been around for a long time. In 1964 [12], Rodbell developed the method of isolation of the stromal vascular fraction (SVF) from adipose tissue. In 1978, Bjontorp [13] found that periadipocytes have the ability for differentiation, which is defined as one of the properties of stem cells. It wasn't until 2001 that Zuk [4] first purified and named the adipose derived stem cells. Since their official inception, the adipose derived stem cells have been extensively studied from basic science to clinical research. In 2004, a German group successfully transplanted adipose derived stem cells to repair the cranium of a 7-year-old girl [14]. In 2005, an experiment for the treatment of incontinence using the adipose derived stem cells was also implemented [11]. The ADSCs have also been shown to improve erectile function in neurogenic and diabetic animal models [15].
Compared to other kinds of adult stem cells, such as bone marrow-derived mesenchymal stem cells, ADSCs possess a clear advantage due to easy and repeatable access to subcutaneous adipose tissue and the simple isolation procedure. Nevertheless, limitations on the purification of ADSCs and the lack of knowledge regarding their molecular characterization are the major hindrances associated with the use of ADSCs.
Despite the importance of ADSCs and many publications on their characterization, the molecular characterization of ADSCs is not well established. By employing flow cytometry [16], histology [8] and other methods [17,18], several candidate cellular markers and genes have been screened (Table). Meanwhile, the cellular origin of ADSCs within adipose tissue remains unknown. Recently, Yamamoto et al [19] used immunofluorescence (IF) staining of mouse adipose tissue to identify cells expressing CD90, CD105, Sca-1, and/or p75NTR. The results showed widespread distribution of each of these markers, suggesting that they are not specific for ADSCs. In another recent study by Zannettino et al [20] attempted to identify ADSCs in human adipose tissue by employing IF staining for cellular markers 1A6.12, 1B5, STRO-1, CD146, and 3G5. While these markers were detected in two large blood vessels of unknown identity, their location in the adipose tissue cannot be inferred due to the lack of adipocytes or any other landmarks in the neighborhood of these two blood vessels. Furthermore, the study did not examine the small vessels (arterioles, venules, or capillaries) in adipose tissue, although the authors did acknowledge that mesenchymal stem cells (MSC), such as ADSCs, likely reside in specialized niches within the micro-vascular networks.
Actually, several lines of evidence suggest that ADSCs are vascular precursor cells. Many studies have shown that SVF contains progenitor cells that are able to differentiate into endothelial cells and participate in blood vessel formation. Also, a recent study demonstrated that SVF cells expressing both pericyte and mesenchymal markers reside in a periendothelial location and stabilize endothelial networks [21]. Another recent study showed that ADSCs transplanted into ischemic cortex preferentially migrate toward micro-vessels where they differentiate into vascular smooth muscle cells [2]. By extensive histology, flow cytometric assay, an updated results show that smooth muscle actin (SMA) and CD31 localized within smooth muscle and endothelial cells, respectively, in all blood vessels examined. CD34 localized to both the intima (endothelium) and adventitia, neither of which expressed SMA. The niche marker Wnt5a was confined exclusively to the vascular wall, within mural smooth muscle cells. Surprisingly, the widely accepted mesenchymal stem cell marker STRO-1 was expressed exclusively in the endothelium of capillaries and arterioles but not in the endothelium of arteries. The embryonic stem cell marker SSEA1 localized to a pericytic location in capillaries and in certain smooth muscle cells of arterioles. Cells expressing the embryonic stem cell markers telomerase and OCT4 were rare and observed only in capillaries. Tang et al also identified the progenitor cells in white adipose tissue within the adipose vasculature [18]. Notably, Matthew S. Rodeheffer reported a similar result by employing a variety of approaches [17]. Based on these findings and evidence gathered from the existing literature, it has been proposed that ADSCs are vascular precursor (stem) cells at various stages of differentiation [8]. These studies serve to solidify the idea that adipose derived stem cells are in fact derived from the adipose vasculature where the stem cells reside in a microenvironment that has been hypothetically named as the adipose derived stem cell niche (Fig 1).
In recent years, the adipose derived stem cells as a new source of adult stem cells has been extensively explored [14,22,23]. The adipose derived stem cells can be developed with a series of steps including isolation, sorting, culture, differentiation and application. Firstly, the adipose tissue need be digested with collagenase type IA, sorted by a cell strainer and specific stem cell markers. These cells can be cultured in regular culture medium and can be induced into different cell types using induction medium. After described steps, the cells can be used for many different purposes. Using flow cytometric sorting, these adipose derived stem cells have been shown to share many of the same cellular markers with the Bone marrow stem cells, such as CD9, CD10, CD13, CD29, CD117, CD34, CD90, CD105 and STRO-1 (Table ).
The ADSCs display multipotency by retaining the ability to differentiate into cell types of different lineages, including neurogenic, chondrogenic, ostogenic, adipogenic, myogenic, cardiomyogenic, vascular/endothelial, hepatic, and pancreatic differentiation (Fig. 2). In the current review, we mainly focus on neurogenic differentiation, smooth muscle differentiation, and endothelial differentiation, which encompass the dominant differentiation pathways for functional cells located within the penile erectile tissue.
It has been shown that ADSCs can be induced by isobutylmethylxanthine (IBMX) to differentiate into neuron-like cells in vitro [5,10,24]. This IBMX-induced neuronal differentiation was mediated by the IGF-I signaling pathway. The significance of these studies is that ADSCs has the potential to treat degenerative neurological diseases including neurogenic ED, which frequently occurs in patients who have undergone pelvic floor surgeries or radiation.
Due to the fact that future clinical applications will likely to use these adult stem cells in an autologous fashion, ADSCs could be induced to differentiate into neuron-like cells which expressed neuronal markers S100, nestin, and NF70. Isobutylmethylxanthine (IBMX), indomethacin (INDO), and insulin were the active ingredients in a previously established neural induction medium (NIM). It was also found that IBMX alone was as effective as NIM in the induction of morphological changes as well as neuronal marker expression. The cellular signaling pathways involved in this neuron differentiation were studied by treating ADSCs with IBMX in the presence or in the absence of each of eight specific inhibitors of different signaling pathways (JAK/STAT, PKA, PI3K, MEK, Wnt/Frizzled, ERK/MAPK, TGF-b, and insulin growth factor [IGF]- I). PPP, a specific inhibitor of IGF-I signaling, was the only inhibitor that showed significant inhibition of IBMX-induced ADSCs neuronal differentiation, as determined by changes in cell morphology in the initial screening. Further examination by immunofluorescence staining showed that the neuronal marker, β-III-tubulin, was highly induced in IBMX-treated ADSCs, and the induction was significantly suppressed by PPP. Western blotting followed by densitometry showed that PPP suppressed IBMX-induced β-III-tubulin expression by 43%, 88%, and 84% when used to treat the cells for 1, 3, and 24 hr, respectively. Treatment of ADSCs with IBMX also led to the phosphorylation of IGF-I receptor at tyrosine 1136 (Y1136), as determined by immunofluorescence staining with an antibody that reacts specifically with Y1136. This effect was also abrogated by PPP. Thus, the IBMX-induced neuron-like differentiation of ADSCs is mediated by IGF signaling through the phosphorylation of IGF-IR at Y1136 [25].
The smooth muscle is a major component of erectile tissues and essential for the normal erectile function. The use of adipose derived stem cells for cell-based tissue engineering and regeneration strategies represents a promising alternative for the treatment of erectile dysfunction. For such strategies to succeed, a reliable source of smooth muscle precursor cells must be identified. In 2006 [11], Rodríguez LV et al checked the capacity of adipose-derived stem cells to differentiate into phenotypic and functional smooth muscle cells in vitro. The cells were cultured in smooth muscle differentiation medium for the differentiation. Smooth muscle differentiation of ADSCs induced genetic expression of all smooth muscle markers and further confirmed by increased protein expression of smooth muscle cell-specific alpha actin (ASMA), calponin, SM22, myosin heavy chain (MHC), and smoothelin. Clonal studies of adipose derived multipotent cells demonstrated differentiation of these cells into smooth muscle cells in addition to trilineage differentiation capacity. Importantly, smooth muscle-differentiated cells, but not their precursors, exhibit the functional ability to contract and relax in direct response to pharmacologic agents. From their result, it has been demonstrated that the adipose-derived cells have the potential to differentiate into functional smooth muscle cells and thus, adipose tissue can be a useful source of cells for treatment of injured tissues where smooth muscle plays an important role.
Furthermore, Lee WC et al [26] explored the regulation of smooth muscle cell (SMC) marker α-smooth muscle actin (α-SMA) during the differentiation of ADSCs to smooth muscle cell. The ADSCs differentiated toward the SMC lineage under the exogenous biochemical stimulation. The immunofluorescence staining and Western blot analysis detected protein expression of the early SMC marker α-SMA in both control and experiment groups. Expression of α-SMA in ADSCs significantly increased when treated with transforming growth factor-β1, while α-SMA expression only slightly increased in the presence of retinoic acid (RA), β-mercaptoethanol and ascorbic acid. Treatment with platelet-derived growth factor-BB, RA and dibutyryl-cyclic adenosine monophosphate decreased the expression of α-SMA significantly.
More interestingly, in 2008, Andersen DC [27] found a non-haematopoietic "side population" of CD45(−) cells within ADSCs possessing the ability to differentiate into smooth muscle cells. Simultaneous qRT-PCR of 64 genes revealed that the freshly isolated CD45(−) was highly enriched for cells expressing genes related to stem cells, the Notch pathway, and early vascular precursors. Notably, the expression of smooth muscle actin, C-met and CD34 together with Angpt2, Flk1, VE-cadherin, and CD31 suggested a phenotypic resemblance to pericytes. It has been observed in vitro myogenic specification of CD45(−) cells when co-cultured with myoblasts. Furthermore, immediate intramuscular engraftment of non-cultured CD45(−) cells gave rise to myofibres and cells lining blood vessels.
Endothelial dysfunction is a prominent feature of a wide variety of diseases including ED, and therapeutic angiogenesis is one of the strategies that have been considered for the restoration of endothelial function. Earlier efforts of this therapeutic strategy largely focused on injection of proangiogenic proteins or vectors expressing such proteins. These efforts were fruitful in pre-clinical studies but encountered obstacles in clinical trials. Growth factor therapy for ED has also been successfully demonstrated in animal models but has not reached clinical trials [28]. On the other hand, recent studies have shifted to cell-based therapies, such as using progenitor and stem cells [29–31].
It has been previously shown that ADSCs were localized within the vasculature of adipose tissue [8] and displayed multipotency, as witnessed by the ability of ADSCs to differentiate into endothelial cells. It has been hypothesized that ADSCs could be used to restore the endothelial function in vasculogenic ED. As a first step, we demonstrated that indeed ADSCs differentiated into endothelial cells in the penile sinusoids. We then sought to identify the mechanism underlying ADSCs endothelial differentiation. Using cell cultures we first tested whether ADSCs could differentiate into endothelial cells when grown in Endothelial Growth Medium 2 (EGM2), a commonly used endothelial growth medium. We observed that switching ADSCs from DMEM to EGM2 for approximately 7 days was sufficient to induce expression of endothelial markers, LDL-uptake, and endothelial tube formation. We also observed that this endothelial differentiation was reversible because switching ADSCs back to DMEM resulted in the disappearance of all of the above-mentioned endothelial characteristics. Upon returning to EGM2, the endothelial characteristic reappeared, albeit at reduced levels. Thus, EGM2 did contain factors necessary and sufficient to induce ADSCs endothelial differentiation. Subsequent experiments led to the identification of FGF2 and vitamin C as the only two plausible factors.
A central question in stem cell research is how stem cells maintain the ability to self-renew and replicate while producing differentiated daughter cells, in addition to which signaling events control stem cell proliferation and differentiation [1,3,7,32,33]. Meanwhile, much research effort has been implemented in manipulating stem cells into desired cell types for use in clinical application. Studies have revealed that stem cells use evolutionarily conserved molecular pathways and machinery for their differentiation and self-renewal. Genes that participate in these events are regulated at different levels, such as transcription, translation, and protein modification.
Initiation of translation of most eukaryotic mRNAs commences with 5' end–dependent recruitment of 40S ribosomal subunits to the mRNA. The 40S subunit carrying the initiator methionine-tRNA and certain eukaryotic initiation factors (eIFs) are thought to scan the mRNA in a 5' to 3' direction until an appropriate start codon is encountered, at which stage a 60S subunit joins to form an 80S ribosome that can decode the RNA into protein. A subset of mRNAs contain internal ribosomal entry sites (IRES), usually in the 5' UTR, enable end-independent initiation to occur and has been recruited as a major translational format under certain stimuli (i.e. stress) which is an initial step in activation of stem cells for differentiation [34,35].
Recently, it has been demonstrated that translational regulation of fibroblast growth factor 2 (FGF2) plays a critical role in maintaining self-renewal and differentiation of ADMSC [36–39]. The human FGF2 mRNA is one of the most striking systems of translational regulation. Its highly structured 5′ leader region contains 5 initiation codons; an AUG coding for an 18 KDa isoform and 4 noncanonical CUGs, coding for high-molecular-weight isoforms (HMW) of 22, 22.5, 24 and 34 KDa. It was shown previously that translation initiation (except for the 34 kDa FGF2 isoform) could be driven by IRES located in the mRNA 5′ untranslated region, allowing translation to occur by a non-classical cap-independent mechanism [36,40]. These different FGF2 isoforms have different localizations and functions. The AUG-initiated 18 kDa isoform is cytoplasmic, and it is secreted and acts by the classical para- or autocrine way involving membrane receptor recognition. In contrast, the CUG initiated FGF-2 isoforms are nuclear and have an intracrine action that involves interaction with nuclear partners. FGF2 IRES activity is regulated in a developmental and tissue-specific manner. It was also noted that FGF2 is the key molecule for maintenance of stemness in ADSCs [41]. In this regard, FGF2 appears to be of similar importance for hADSCs self-renewal as leukemia inhibitory factor (LIF) is for mouse ESCs.
In 2003 Deng et al showed that bone marrow stem cells (BMSC) transduced with eNOS were able to improve the erectile function of aged rats [42]. In 2004 our research showed that ESC transfected with brain-derived neurotrophic factor (BDNF) could restore the erectile function of rats whose cavernous nerves were experimentally damaged [31]. Bivalacqua et al [29,30] showed that BMSC alone or transduced with eNOS were able to reverse age-associated ED. Song et al [43] showed that magnetic resonance could be used to non-invasively evaluate human BMSC in corpus cavernous of rats and rabbits. Also, Song et al showed that immortalized human BMSC (by v-myc transfection) transplanted into rat corpus cavernosum could differentiate into endothelial and smooth muscle cells.
Also, the skeletal muscle-derived stem cells (MDSCs) have been converted into smooth muscle cells (SMCs) both in vitro and in vivo, and were shown to recover erectile function in the aged rats [44]. Although these results suggest exogenous stem cell implantation and/or endogenous stem cell modulation might be a viable therapeutic approach for age-related ED, the application of MDSCs obtained from muscle is limited due to the source and number of this kind of stem cell.
Song et al investigated the feasibility of applying neural crest stem cells (NCSCs) to repair injury in the penile cavernosum and found that these stem cells differentiated into either endothelial cells or smooth muscle cells, as shown by their expression of cell type-specific markers. However, the function of these differentiated cells had not been explored in their experiment [45].
Garcia et al isolated human ADSCs from a liposuction procedure, and administered according to a strict protocol that involves infusion of the cells into the target lesion along with fibrin glue in a human phase IIb clinical study [46]. The clinical results satisfied the effectiveness to induce healing in a complex of perianal fistulas, though the underling mechanism needs to be further explored.
Also, human ADSCs have been successfully applied to reverse urethral incontinence in an animal model in 2005 [47]. The ADSCs were also isolated from human lipoaspirate, labeled with a fluorescent tag and suspended in Hanks' balanced salt solution. The multiple animal models, including 8 Rnu athymic rats and 6 SCID mice underwent laparotomy and injection of ADSCs into the bladder and urethra. The ADSCs remained viable for up to 12 weeks in the lower urinary tract and differentiated into smooth muscle cells, which implies that ADSCs may provide a feasible and cost-effective cell source for urinary tract reconstruction. The major defect of this study is the lack of functional studies on those animals.
In our laboratory, a pilot experiment has been conducted [15]. Thirty 3-month old Sprague-Dawley male rats were randomly divided into three groups, including the sham, control and ADSCs injection groups. Following bilateral cavernous nerve crush injury in the control and ADSCs injection groups, the autologous adult ADSCs were isolated from the rats. The ADSCs were cultured in vitro and then transplanted back into the rat penis in the ADSCs injection group, while the sham and control group were injected with PBS into the penis. Five weeks later, the erectile function of each group was checked by measuring the intracavernosal pressure (ICP), and the fate of transplanted ADSCs was assayed by immunochemical histology. The results indicated that the mean increase in ICP for animals in the sham vs. untreated crush injury groups was 106.2 ±14.1cmH2O versus 18.0 ±8.0 cmH2O, respectively (p<0.05). Rats treated with ADSCs after crush injury significantly demonstrated greater ICP responses relative to untreated controls (p<0.05) with ICP values at 85.1 ±7.5cmH2O. There was evidence that some stem cells labeled with BrdU appeared to differentiate into endothelial cells and smooth muscle cells within the erectile tissue.
After analyzing our results, several possible mechanisms underlying the treatment were proposed. First, the cell-based mechanism indicated that ADSCs differentiated into local functional cells, including smooth muscle cells and endothelium. Second, the growth factor-based mechanism indicated that the growth factors secreted from the ADSCs underwent one of the following situations: (1) Recruit local stem cells and activity to differentiation; (2) attract the systemic stem cells to the penis by homing effect; (3) IGF-1 promote local functional cell growth; (4) the neurotrophic effect to promote nerve regeneration, which need to be confirmed by further studies.
The adipose-derived stem cells are regarded as candidates for the treatment of erectile dysfunction due to many factors. These stem cells can easily be obtained in large quantities under local anesthesia, they possess the potential to undergo long-term proliferation, self-renewal and multipotent differentiation, and they can serve as a vehicle for release of neurotrophins, such as nerve growth factor, to repair damages due to diabetes or pelvic surgery.
In addition to using adipose derived stem cells for treatment of erectile dysfunction, there are several other kinds of andrology disorders that can benefit from stem cell therapy, including the reconstruction of penile tissue, enlargement of the penis, and strengthening of the vaginal muscle. There is also the potential application for use of adipose derived stem cells in steroid hormone therapy.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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This is an India-inspired restaurant which you can tell from the smell, décor and food served. Thinking that they serve Italian food, we mistakenly went here and ended up ordering the most Italian food they have – mozzarella, basil and tomato on chapatti. Lol. They have a good selection of cakes so we ordered the banana-caramel chiffon and also a... More
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ConnecT1D Teen Group / Teen Leadership Camp
ConnecT1D is hosting its first Teen Leadership Camp this summer from August 7-10. This first of its type camp will be a three-day / three-night program held at Warm Beach Camp in Stanwood.
This Camp is specifically for T1 teens between the ages of 15 and 18. It will emphasize personal independence, managing transitions to life beyond high school and of particular excitement to us at ConnecT1D, build leadership skills for campers. We expect an outcome from Camp to be a newly revitalized year round teen program at ConnecT1D, run by teens, led by teens, managed by teens and built by teens.
That's right. Anyone can go to camp and do a ropes course. But at the ConnecT1D Teen Leadership Camp, you get the ropes course AND the chance to build a sustainable teen program under the guidance and mentorship of other Type 1 mentors.
With that, here's what you can do!
- Save the Dates August 7-10, 2017 for the Teen Leadership Camp. Sign up below to get notified when registration opens up.
- Join the Planning Committee! We are looking for teens and young adults to help build this Camp. Read below for more info and to apply.
- Be a mentor! We are also recruiting college age and young adults with T1D to serve as mentors to build this program and volunteer at Camp. Read below for more info and to apply.
- Spread the Word. Send this website to other teens with T1D! We're so excited to be building another great program for the T1D community and can only reach the people that you help us to. Let's do this!
Join the Planning Committee
ConnecT1D is actively recruiting teens and young adults to serve on the planning committee for the Teen Leadership Conference.
This committee is led by Jake Johnston and Jamie Elzea and will meet monthly via Skype. The first meeting is scheduled for Monday, March 6 at 6:30 PM.
Committee members are asked to commit to monthly meetings and to take on additional projects and provide input as needed. This is expected to require 1-3 hours per week. All tasks can be done electronically and remotely and we use a collaboration platform called BaseCamp to make sure we're all on the same page with our work.
You do not need to have any specific background in order to be a part of this committee. Instead, we are looking for smart, motivated, collaborative people that believe in our vision for a teen camp and program.
For some high school age students, this work may contribute to your volunteer or community service requirements.
About the Teen Leadership Camp
ConnecT1D is hosting the first Teen Leadership Camp for teens with Type 1 Diabetes ages 15-18 August 7-10, 2017 at Warm Beach Camp in Stanwood, Washington.
Camp will be three days and three nights and include all linens, meals, snacks and materials. Camp will be staffed by ConnecT1D volunteers and have on site medical support.
We expect an outcome from Camp to be the creation of a year-round teen program for ConnecT1D, led and managed by teens. We further expect to elect one or more teens to a leadership council that will work with the ConnecT1D Board of Directors to give a voice to teens for all of ConnecT1D's activities and to serve as a liaison to the Board for the teen program.
At other camps, you get lifetime memories, a friendship bracelet and a merit badge. At the ConnecT1D Teen Leadership Camp, you get all that and the chancee to serve on the Board of Directors with the training and mentorship needed to be an effective force!


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Situated in Jefferson City, this hotel is within a 15-minute walk of Missouri State Capitol, Miller Performing Arts Center, and Cole County Historical Society. ...
This was a very nice and quiet hotel stay at I will do it again soon sometime
This family-friendly Columbia hotel is located in the historical district, within 1 mi (2 km) of Stephens College and Columbia College. Museum of Art and Archaeology ...
I loved this hotel! The room was spacious and comfortable. The bar and restaurant on the property are also highly recommended! The front desk staff were also very accommodating and friendly.
Situated near the airport, this hotel is within 3 mi (5 km) of Lazer Lanes, Mizzou Arena, and Faurot Field. University of Missouri is 3 mi (4.8 km) away.
Great place - conveniently located a few miles from the University of Missouri. Great staff.
Located in the heart of Columbia, this hotel is within a 10-minute walk of Stephens College and Columbia College. University of Missouri and Museum of Art and ...
I travel tonColumbia on business regularly. Sometimes I stay at the Broadway because they have an airport shuttle so I don't need a rental car.
Situated in Columbia, this hotel is 0.7 mi (1.1 km) from Columbia Mall and 2.8 mi (4.5 km) from Columbia College. Shelter Gardens and Museum of Anthropology ...
This was a fine hotel for what we needed, which was one night in Columbia. The bed was comfortable, but I wish there had been 4 pillows on the bed and not just 3. The shower was nice, but it would have been nice to have a hair dryer in the bathroom. Unfortunately, we booked a non-smoking room, but ...
Situated in Columbia, this hotel is 2.7 mi (4.3 km) from Stephens College and 2.9 mi (4.7 km) from Columbia College. University of Missouri and Museum of Art ...
Absolute oasis after driving 15 hours! I wish we could have just stayed there!
Situated in Columbia, this hotel is 2.6 mi (4.1 km) from Stephens College and 3.1 mi (4.9 km) from University of Missouri. Columbia College and Museum of Art ...
the sheets smelled very fresh, the room looked recently renovated, a nice stay for a good price for the night.
Situated in Columbia, this inn is within 1 mi (2 km) of Columbia Mall and Shelter Gardens. Museum of Anthropology is 2.3 mi (3.8 km) away.
Friendly staff accommodated our needs. Room was clean but hall ways and elevators weren't the cleanest. Breakfast was reasonable as well and it was nice and quiet when it needed to be. Would stay there again.
Situated in the business district, this hotel is 1 mi (1.7 km) from Mizzou Arena and 2.8 mi (4.5 km) from Columbia College. Faurot Field and Museum of Art and ...
Stoney Creek is a good, clean hotel that is about 1 mile for Mizzou.
Situated in Columbia, this hotel is 2.4 mi (3.9 km) from Stephens College and 2.8 mi (4.5 km) from Columbia College. University of Missouri is 2.9 mi (4.7 km) ...
This hotel was close to I70 and easy to get to with our truck and trailer. The staff was friendly. We picked it for being pet friendly and was a good choice.
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Edmonton International Street Performers Festival
You are invited to Sir Winston Churchill Square in downtown Edmonton for another Hysterical & Hilarious Edmonton International Street Performers Festival. Home to over 1500 Exciting & Entertaining outdoor performances by musicians, jugglers, acrobats and unicyclists, StreetFest is proud to present another ten days of international street artists.
Children of all ages will enjoy the Colourful & Comical face-painters and rovers, as well as the Be Your Own Busker Workshops and Kids World activities. Riproarin & Rambunctious good times flow into the evening with Indoor Late Night Madness performances and daily Troupe du Jour group shows.
- Sir Winston Churchill Square Address: Downtown Edmonton AB
Location Information


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"The summer is going great, we are just working out," Hampton said. "I am going to spend some time some time working on leg strength this summer.
"I really want to improve that area of my game so when I have to take on the double-teams, I can disengage and chase the ball from the inside.
"I am also hoping to improve on my speed. I am quick on the interior, but I would really like to make more plays outside the tackles."
Hampton plays the end position now, and could probably play that at the next level, but is really being looked at to play inside. With his size and speed, 4.89/40-yard dash, he creates some mismatch problems.
"I play defensive end now, but we play a 3-4 so I am either lined up as a 5 or a 7 usually. All of the teams recruiting me like me to play defensive tackle in college.
"As a defensive tackle now, I think that I am able to get around the bigger guys now. I am not that big really and am able to get around.
"Also, the offensive lineman that I have to engage, I can get them up top and get away from them because I am stronger than them."
Hampton committed about a month and a half ago. But, that was when Hampton just had two offers. That number has risen, sharply, since committing.
"I committed to Stanford. I think that I committed to them a month and a half ago when I went up there on an unofficial visit.
"I was really only holding one other offer from Northwestern. I have picked up some other offers since then. I have 16 offers now.
"I picked offers from Nebraska, Texas Tech, Wake Forest, Duke, Colorado, Missouri and there are some others. Notre Dame is close."
That sharp rise in offers is cause for Hampton to remain committed, but keep some options open. He is going to continue to evaluate other offers.
"Honestly, yes I am. I am going to continue to evaluate my options as I go forward, but I am still committed to Stanford as of right now."
It's not decided yet if Hampton will take any other official visits this fall. But, if he had to, there are three schools right now that he would consider taking one to.
"I am still debating on taking some other official visits besides the one to Stanford. If I were to take some other visits it would have to be to Nebraska, Texas Tech and Wake Forest."
Hampton is interested in the tradition at Nebraska; the tradition and a head coach that came from a school that he knows a little something about.
"It would have to be their tradition. It would be their tradition and their coaching staff. Bo Pelini came from LSU and I am originally from Louisiana.
"I kept up with following Bo since he left LSU and went to Nebraska. He has the ability to produce the type of talent that goes onto the next level."


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Survivors 20 Years Later, Alberto
Print advertisment created by Basevich, Argentina for Embassy of Israel, within the category: Public Interest, NGO.
March 17, 1992-2012. Terrorist attack against the Embassy of Israel in Argentina. Terrorism. Zero tolerance.
Highest Rated
If a brand's advertising and it's behavior don't line up, people will (and should) reject it. So no.
mr.Creative dir. forgetting something about terrorist attacks and genocide against Palestine. Terrorism. Zero tolerance
Creativity is a natural extension of our enthusiasm
If a brand's advertising and it's behavior don't line up, people will (and should) reject it. So no.
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We love to see so many from the SOS Radio community stepping up to serve! Earlier this year we celebrated Shrove Tuesday (aka International Pancake Day) in partnership with The Las Vegas Metropolitan Police Department and Beth Fisher from Channel 13 Action News! Scott Herrold, JD Smith & Dan Young raced Metro Police Officers in a pancake race for Hope for Prisoners! (It's an amazing ministry helping ex-offenders get plugged back into jobs and society)
Author Lori Wilhite talks about the challenges that pastor's families face. She talks about leading past an empty tank and how to finish strong. This will help you better understand what pastor's families deal with.
It's Pastor Appreciation Month! Lori is founder of LeadingAndLovingIt.com and is part of the team at Central Christian Church.
Jose Boveda & Nyla Christian are part of the Mayor's Faith Initiative in Las Vegas. It's a collective of people from the faith community who are working to tackle our city's biggest challenges. Click www.LVmayorsFaithInitiative.com if you're interested in reading more!
Matt Redman talks about the true heart behind worship to God. He talks about managing a schedule with 5 kids vs rationing your emotional energy. He also talks about how culture and faith are moving in the UK!
Here's a chat with music industry exec and artist manager Keith Stancil about pushing back against pride, fame & ego. His new book is called Creating Monsters!
Scott Herrold had Sean Astin on his show this week. You'll remember Sean from Lord of the Rings, Goonies & Rudy. He's in the new film Woodlawn and it's powerful! You know I had to ask him about Goonies right???
Tim Timmons talks about how we indirectly teach our kids horrible prayers sometimes. He talks about what the kingdom of God actually is and why Jesus talked so much about it. Tim also shares the story about his cancer diagnosis 14 years ago where he was given 5 years to live.
Author Lori Wilhite talks about building into the families of our local pastors! She shares some insight into what most people don't know about their pastor's families. Lori is one of the founders of LeadingAndLovingIt.com. It's a resource for the wives of pastors all over the country!
Best selling author Jen Hatmaker was on SOS Radio with Scott Herrold recently. You might know her from some of her books like Seven or Interrupted or maybe you've seen her family on HGTV. This discussion about parenting, faith, American worldview and fashion is hilarious! Click here for the audio!
Susan Mackert from Child Evangelism Fellowship talks about the rights that students have in public school to live out and share their faith. She talks about how Good News Clubs are being planted in schools across the country!


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Korean master illustrator Kim Jung Gi has freehand ability at one of the highest levels in the world. Mindblowing.
Adam Rifkin stashed this in Penmanship
Stashed in: Art!, Korea, Best Videos, Mind Blown!, woahdude
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Adverse Events |BENICAR (olmesartan medoxomil) HCP
Banner - Safety
Safety - BENICAR adverse reactions
The only adverse reaction that occurred in more than 1% of patients treated with BENICAR and at a higher incidence versus placebo was dizziness (3% vs 1%).
The following adverse reactions occurred in placebo-controlled clinical trials at an incidence of more than 1% of patients treated with BENICAR, but also occurred at about the same or greater incidence in patients receiving placebo: back pain, bronchitis, creatine phosphokinase increased, diarrhea, headache, hematuria, hyperglycemia, hypertriglyceridemia, influenza-like symptoms, pharyngitis, rhinitis, and sinusitis.
In clinical studies, treatment with BENICAR and BENICAR HCT was well tolerated. Events generally were mild, transient, and had no relationship to the dose of BENICAR or BENICAR HCT.
The withdrawal rates due to adverse reactions for BENICAR or BENICAR HCT were similar to placebo: BENICAR (2.4% vs 2.7%, respectively); BENICAR HCT (2.0% vs 2.0%, respectively).
Safety - BENICAR HCT adverse reactions
Adverse reactions reported in >2% of patients taking BENICAR HCT and more frequently than placebo included:
Selected Safety Information: IMPAIRED RENAL FUNCTION
Monitor for worsening renal function in patients with renal impairment while on BENICAR, BENICAR HCT, AZOR, or TRIBENZOR.
Please see Important Safety Information on this page for more information on impaired renal function regarding BENICAR, BENICAR HCT, AZOR, and TRIBENZOR.
- When pregnancy is detected, discontinue BENICAR, BENICAR HCT, AZOR, or TRIBENZOR as soon as possible
- Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See WARNINGS AND PRECAUTIONS: Fetal Toxicity
Please see Important Safety Information on this page for BENICAR, BENICAR HCT, AZOR, and TRIBENZOR.
Please see Full Prescribing Information for BENICAR and BENICAR HCT, including Boxed WARNINGS regarding Fetal Toxicity.
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4 Prod - Important Safety Information
BENICAR (olmesartan medoxomil), BENICAR HCT (olmesartan medoxomil-hydrochlorothiazide), AZOR (amlodipine and olmesartan medoxomil), and TRIBENZOR (olmesartan medoxomil, amlodipine, hydrochlorothiazide) are indicated for the treatment of hypertension to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including the class to which these drugs principally belong. There are no controlled trials demonstrating risk reduction with BENICAR, BENICAR HCT, AZOR, or TRIBENZOR.
Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals.
BENICAR, BENICAR HCT, AZOR, and TRIBENZOR can be used alone or with other antihypertensive agents.
AZOR is indicated as initial therapy in patients likely to need multiple antihypertensive agents to achieve their blood pressure goals.
Initial therapy with AZOR is not recommended in patients ≥75 years of age or in hepatically impaired patients.
BENICAR HCT and TRIBENZOR are not indicated for the initial therapy of hypertension.
Important Safety Information for BENICAR®, BENICAR HCT®, AZOR®, and TRIBENZOR®
- When pregnancy is detected, discontinue BENICAR, BENICAR HCT, AZOR, or TRIBENZOR as soon as possible
- Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See WARNINGS AND PRECAUTIONS: Fetal Toxicity
Do not co-administer aliskiren with BENICAR, BENICAR HCT, AZOR, or TRIBENZOR in patients with diabetes.
BENICAR HCT and TRIBENZOR are contraindicated in patients with anuria. BENICAR HCT is contraindicated in patients with hypersensitivity to any component of BENICAR HCT. TRIBENZOR is contraindicated in patients with hypersensitivity to other sulfonamide-derived drugs.
Morbidity in Infants: Children <1 year of age must not receive BENICAR for hypertension. Safety and effectiveness of AZOR, BENICAR HCT or TRIBENZOR have not been established in pediatric patients.
Fetal Toxicity: BENICAR, BENICAR HCT, AZOR, and TRIBENZOR are Pregnancy Category D.
Hypotension in Volume- or Salt-Depleted Patients: In patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients (eg, those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with BENICAR, BENICAR HCT, AZOR, or TRIBENZOR.
Impaired Renal Function:
Patients whose renal function may depend in part upon the activity of the renin-angiotensin-aldosterone system (eg. patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion), may be at particular risk of developing acute renal failure on BENICAR, BENICAR HCT, AZOR and TRIBENZOR. Monitor renal function periodically in these patients. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on BENICAR, BENICAR HCT, AZOR and TRIBENZOR.
Safety and effectiveness of BENICAR HCT in patients with severe renal impairment (CrCl ≤ 30 mL/min) have not been established. Avoid use of TRIBENZOR in patients with severely impaired renal function (creatinine clearance ≤30 mL/min). If progressive renal impairment becomes evident, consider withholding or discontinuing TRIBENZOR.
Sprue-like Enteropathy: Severe, chronic diarrhea with substantial weight loss has been reported in patients taking olmesartan months to years after drug initiation. Intestinal biopsies of patients often demonstrated villous atrophy. If a patient develops these symptoms during treatment with olmesartan, exclude other etiologies. Consider discontinuation of BENICAR, BENICAR HCT, AZOR, or TRIBENZOR in cases where no other etiology is identified.
Hepatic Impairment: Initial therapy with AZOR or TRIBENZOR is not recommended in hepatically impaired patients. In patients with severe hepatic impairment, exercise caution with AZOR and avoid use of TRIBENZOR. Thiazides (a component in BENICAR HCT and TRIBENZOR) may cause minor alterations of fluid and electrolyte balance that may precipitate hepatic coma in patients with impaired hepatic function or progressive liver disease.
Electrolyte and Metabolic Imbalances: BENICAR HCT and TRIBENZOR contain hydrochlorothiazide which can cause hypokalemia and hyponatremia. Hypomagnesemia can result in hypokalemia which may be difficult to treat despite potassium repletion. BENICAR, BENICAR HCT, AZOR and TRIBENZOR also contain olmesartan, a drug that inhibits the renin-angiotensin system (RAS). Drugs that inhibit the RAS can cause hyperkalemia. Monitor serum electrolytes periodically.
Hydrochlorothiazide may alter glucose tolerance and raise serum levels of cholesterol and triglycerides.
Hypersensitivity Reaction: Hypersensitivity reactions to HCTZ (a component in BENICAR HCT and TRIBENZOR) may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history.
Systemic Lupus Erythematosus: Thiazides (a component in BENICAR HCT and TRIBENZOR) have been reported to cause exacerbation or activation of systemic lupus erythematosus.
Acute Myopia and Secondary Angle-Closure Glaucoma: Thiazides can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Discontinue HCTZ (a component in BENICAR HCT and TRIBENZOR) as rapidly as possible in these patients.
Vasodilation: Although vasodilation attributable to amlodipine (a component in AZOR and TRIBENZOR) is gradual in onset, acute hypotension has rarely been reported after oral administration. Patients with severe aortic stenosis may be at particular risk.
Increased Angina and/or Myocardial Infarction: Patients taking AZOR or TRIBENZOR, particularly those with severe obstructive coronary artery disease, may develop increased frequency, duration, or severity of angina or acute myocardial infarction on starting calcium channel blocker therapy or at the time of dose increase.
Laboratory Tests: There was a greater decrease in hemoglobin and hematocrit with AZOR compared to either component alone. Other lab abnormalities may include increased blood creatinine levels and hyperkalemia (olmesartan medoxomil), hepatic enzyme elevations (amlodipine), and increased cholesterol and triglyceride levels (HCTZ).
Non-Steroidal Anti-Inflammatory Agents: Concurrent administration of non-steroidal anti-inflammatory drugs (NSAIDs) may lead to increased risk of renal impairment (including possible acute renal failure) and loss of antihypertensive effect of BENICAR, BENICAR HCT, AZOR, and TRIBENZOR.
Dual Blockade of the Renin-Angiotensin System (RAS): Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Most patients receiving the combination of two RAS inhibitors do not obtain any additional benefit compared to monotherapy. In general, avoid combined use of RAS inhibitors. Closely monitor blood pressure, renal function, and electrolytes in patients on BENICAR, BENICAR HCT, AZOR, or TRIBENZOR and other agents that affect the RAS.
Do not co-administer aliskiren with BENICAR, BENICAR HCT, AZOR, or TRIBENZOR in patients with diabetes. Avoid use of aliskiren with BENICAR, BENICAR HCT, AZOR, or TRIBENZOR in patients with renal impairment (GFR <60 mL/min).
Concurrent Use with Colesevelam Hydrochloride: Concurrent administration of colesevelam hydrochloride with BENICAR, BENICAR HCT, AZOR, or TRIBENZOR reduces the systemic exposure and peak plasma concentration of olmesartan. Consider administering olmesartan at least 4 hours before the colesevelam hydrochloride dose.
Effect of Amlodipine on Simvastatin: Due to increased exposure to simvastatin, when co-administered with amlodipine (a component in AZOR and TRIBENZOR), do not exceed doses of greater than 20 mg daily of simvastatin.
Lithium: Increases in serum lithium concentrations and lithium toxicity have been reported with concomitant use of olmesartan or thiazide diuretics. Monitor lithium levels in patients receiving BENICAR, BENICAR HCT, AZOR, or TRIBENZOR and lithium.
Antidiabetic drugs: Dosage adjustment of the antidiabetic drug may be required due to hydrochlorothiazide (a component of BENICAR HCT and TRIBENZOR).
Cholestyramine and colestipol: Reduced absorption of thiazides. Consider administering BENICAR HCT 4 hours before or 4-6 hours after the administration of the resin.
Corticosteroids, ACTH: Intensified electrolyte depletion, particularly hypokalemia due to hydrochlorothiazide (a component of BENICAR HCT and TRIBENZOR).
BENICAR: The only adverse reaction that occurred in >1% of patients treated with BENICAR and more frequently than placebo was dizziness (3% vs 1%).
BENICAR HCT: Adverse reactions reported in >2% of patients taking BENICAR HCT and more frequently than placebo included nausea (3% vs 0%), hyperuricemia (4% vs 2%), dizziness (9% vs 2%), and upper respiratory tract infection (7% vs 0%).
AZOR: The most common adverse reaction (incidence ≥3%) in patients treated with AZOR was edema.
TRIBENZOR: The most frequently reported adverse reaction was dizziness (5.8% to 8.9%). The other most frequent adverse reactions occurring in ≥2% of patients treated with TRIBENZOR were peripheral edema (7.7%), headache (6.4%), fatigue (4.2%), nasopharyngitis (3.5%), muscle spasms (3.1%), nausea (3.0%), upper respiratory tract infection (2.8%), diarrhea (2.6%), urinary tract infection (2.4%), and joint swelling (2.1%).
Nursing Mothers: Avoid use while nursing; discontinue either nursing or the drug.
Please see Full Prescribing Information for BENICAR, BENICAR HCT, AZOR, and TRIBENZOR.


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Tooth Sensitivity and How to Remedy It
Sensitive teeth can be the cause of sudden, sharp, and often searing pain that can radiate deep into the jaw. Those with sensitive teeth may be affected in their daily activities. Pain may become so severe that these individuals avoid brushing for fear of the pain. However, this can lead to even more problems with the teeth.
Teeth that are considered to be sensitive cause pain to the sufferer. The most common triggers for this type of pain include exposure to hot or cold or and by eating foods that are sweet. Some individuals have additional triggers, such as eating food or drinking liquids that are sour. Breathing in air that is cold can sometimes trigger the pain of sensitive teeth.
Teeth become sensitive when underlying dentin is exposed. To combat this problem, you can take supplements that include Vitamin B1, calcium, and Vitamin D to help strengthen teeth. Avoid acidic foods and drinks which can cause weakening of the tooth surface. Try not to grind your teeth. Be sure to brush teeth gently and use a soft toothbrush to avoid wearing away the protective tooth enamel.
It is important to use oral hygiene products that contain fluoride to strengthen tooth enamel. The dentist might even recommend a toothpaste that is designed specifically for sensitive teeth. If you feel you might suffer from tooth sensitivity, make an appointment with Dr. Frame, Santa Clara dentist, to determine a treatment plan that is right for you.
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People who are looking for real estate opportunities within unique South Florida communities will find Hollywood real estate options to be one of today's best that today's property market has to offer, especially for those who are looking for more affordable homes and condos which are located within a city that has great beaches and so much more.
Hollywood real estate options are located within a community located north of the city of Aventura and south of Fort Lauderdale. Residents of the community come to find a touch of convenience as the Fort Lauderdale International Airport is situated minutes away.
One of the strongest points of the community is its arts scene as there are several art galleries which accommodate to the growing number of artists who thrive within the area. Furthermore, there are outstanding boutiques, shopping centers, cafeterias and other dining options available all throughout the community.
Of course, the community's excellent beaches which showcase the natural beauty of South Florida are one of the major attractions that make Hollywood real estate options so attractive to people from all around the world.
If you would like to find out about the availability of Hollywood real estate options on today's property market, you are welcome to browse through our online listings for details on Hollywood homes, Hollywood condos, and other real estate options within the community. If you would like to receive personal assistance, you may contact our team of professional agents for more information.