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Angelos M. Stergiou, MD, ScD h.c., Chief Executive Officer & Vice Chairman of the Board
Angelos M. Stergiou, MD is Chief Executive Officer and Vice Chairman of SELLAS Life Sciences Group. He brings more than 15 years of experience in the global pharmaceutical industry, leading companies and people from scientific research through regulatory approval to develop medicines that address compelling medical needs.
Prior to joining SELLAS, Dr. Stergiou held positions of increasing responsibility in the United States and Europe in pharma and biotechnology companies including PAION AG, Accentia Biopharmaceuticals, BioVest International, Anavex Life Sciences as well as Clinical Research Organizations. Dr. Stergiou has held specific roles ranging from Medical Director, Head of Clinical Research, Vice President and President, Product Development, with responsibility for medical affairs, clinical research and development, pharmacovigilance, clinical operations, project management, regulatory affairs, biostatistics and chemistry, manufacturing and controls (CMC) as well as Chief Medical Officer and Chief Operating Officer. He also founded a boutique NY-based health economics and pricing-reimbursement and health access company, Genesis Life Sciences, and performed work for big pharma.
Dr. Stergiou is a Fellow of the Royal Society of Medicine (UK), active member of the World Medical Association, the American Academy of Pharmaceutical Physicians and Investigators, the Association of Clinical Research Professionals, International Society for Pharmacoeconomics and Outcomes Research, amongst others Dr. Stergiou holds a Doctor of Medicine degree and is a graduate of Kentucky Wesleyan (USA) and has done elective clinical work in interventional cardiology and surgery at the General Hospital Hagen and the University of Cologne. He is a frequent speaker and lecturer at renowned Universities in the US and Europe and has experience with all major global health authorities.
William Pollett, ACA, CFA, Chief Financial Officer
William (Bill) Pollett is the Chief Financial Officer of SELLAS Life Sciences Group. Mr. Pollett brings over 25 years of financial management and capital markets experience to the Company.
Prior to joining SELLAS in September 2016, Mr. Pollett was President and Chief Executive Officer of Blue Capital, the wholly-owned asset management company of Montpelier Reinsurance Holdings Ltd ("Montpelier"; NYSE: "MRH"). In that role he raised nearly one billion dollars of capital in various private and public investment vehicles, investing primarily in catastrophe reinsurance products, including the successful Initial Public Offering in 2012 of Blue Capital Global Reinsurance Holdings Ltd on the London Stock Exchange (LSE: "BCGR"), and Blue Capital Reinsurance Holdings Ltd in 2013 on the New York Stock Exchange (NYSE: "BCRH"). Mr. Pollett concurrently served as President, Chief Executive Officer and a Director of BCRH, President, Chief Executive Officer of Blue Water Re, a licensed reinsurance company, and Blue Capital Management Ltd., a registered investment advisor, and as Chief Corporate Development and Strategy Officer and Treasurer of Montpelier. Mr. Pollett resigned from all positions at Blue Capital and Montpelier following its acquisition by Endurance Specialty Holdings Ltd. (NYSE: "ENH") in 2015.
Prior to joining Montpelier in 2006, Mr. Pollett worked for five years with the ACE Group (now Chubb), initially as Chief Financial Officer of ACE Tempest Re, the reinsurance subsidiary and latterly as Senior Vice President and Senior Financial Analyst of ACE Limited, the holding company. Prior to the ACE Group, Mr. Pollett worked for the OIL Group of Companies for seven years in a number of roles including Controller and Treasurer and, prior to that, was an auditor with Coopers & Lybrand in London and Bermuda for five years. He holds a Bachelor of Commerce (Honours) degree from Edinburgh University, and is a Chartered Financial Analyst (CFA Institute) and Chartered Accountant (ICAEW).
Nicholas Sarlis, MD, PhD, FACP, SVP, Chief Medical Officer
Dr. Nicholas J. (Nick) Sarlis is an experienced clinician and recognized expert in the global pharmaceutical market with a focus in Oncology and Hematology. He has a deep understanding of the status of and emerging trends in clinical & translational research and patient care in Oncology at a global scale and specialized knowledge in medical affairs and late clinical development (US and EU).
As former Vice President and Head of Global Medical Affairs at Incyte Corporation, Dr. Sarlis led a global team supporting targeted and immuno-oncology pipeline agents. He led the integrated medical affairs plan to support the late clinical development of the innovative immuno-enhancer epacadostat and the original indoleamine 2,3-dioxygenase type-1 (IDO1) inhibitor. Dr. Sarlis and his team supported the highly successful successive launches of ruxolitinib [Jakafi®] – the original Janus kinase (JAK) inhibitor- in myelofibrosis and polycythemia vera. Prior to his time at Incyte, Dr. Sarlis held senior positions at Sanofi Aventis having led medical teams for launching key oncology and cancer supportive care products (US & EU).
He received his medical degree and doctorate from the University of Athens, and a Ph.D. in Molecular Biology/ Neuroendocrinology from the Imperial College in London. Sarlis is Board Certified by the American Board of Internal Medicine, and previously served as senior faculty at the National Institutes of Health and Associate Professor at MD Anderson Cancer Center.
Dr. Sarlis has published more than 130 articles (peer-reviewed papers, textbook chapters and monographs). He has received numerous awards, being most recently nominated as the recipient of the 2016 Annual Award by Cancer Research and Treatment Fund (CR&T). He is a Fellow of the American College of Physicians (FACP), the American College of Endocrinology (FACE), the Royal Society of Medicine (UK; FRSM), and the Molecular Medicine Society (FMMS).
Dr. Jonathan Eckard, Ph.D. Chief Business and Strategy Officer
Jonathan Eckard has over 10 years of Wall Street experience following the biotechnology sector, bringing to SELLAS both important industry insights and an understanding of the healthcare equity markets. During his time on Wall Street, he received several accolades including Institutional Investor "Best up-and-comer" and "Rising Star" in Biotechnology research.
Most recently Jonathan was a Director and Senior Equity Research Analyst at Barclays Capital Markets in New York covering the small- and mid-cap Biotechnology sector. Prior to joining Barclays, Jonathan worked for three years at Citi where he covered the Biotechnology and Specialty Pharmaceuticals sectors. Previously he spent five years at Leerink Swann and two years at HSBC working in Biotechnology equity research.
Prior to his career in financial services, Jonathan was in academia conducting cancer research and teaching at the NYU School of Medicine. He earned a BS in Biochemistry from Ohio University, an MS in Toxicology and a PhD in Toxicology and Carcinogenesis from NYU School of Medicine.
Martin G. Baum, Chief Operating Officer
Martin G. Baum brings to SELLAS over 25 years' experience building and leading global biopharmaceutical companies through continued growth and has held senior executive positions in commercialization, market access, sales and operations.
Most recently, Mr. Baum served as founding partner and Managing Director of Komedica, a healthcare consulting firm. Previously, he founded and served as President and Chief Executive Officer of Vestiq Pharmaceuticals, which was sold to a holding of Praelia Pharmaceuticals Inc. in 2013. Prior to this, Mr. Baum was the President and Chief Executive Officer of Turnberry Development and previously was Founder and Chief Executive Officer of TEAMM Pharma, a specialty pain company that he sold to Accentia Biopharma and took public in 2005. Prior to this, he held the position of Senior Vice President, Commercial Operations at DJ Pharmaceuticals, where he helped achieve profitability within two years and sold the Company to Biovail Corporation. He also was a founding member and served as Senior Vice President of Operations and BD at Skye Pharma PLC, an international company focused on generics and novel drug delivery technologies.
He began his career with Merrell Dow Pharmaceuticals and GlaxoSmithKline Pharmaceuticals. Mr. Baum is a founding member of Health Scape Data and sits on the board of Inno BioPharma, an early stage oncology development company spun out of the University of Iowa. Mr. Baum graduated from the University of Toledo, with BS degrees in Human Life Sciences and Business Administration.
Gregory M. Torre, PhD, JD, Chief Regulatory and Quality Control Officer and SVP, Technical Operations
Gregory M. Torre, PhD, JD, is a scientist-attorney with 35 years of hands-on international executive leadership experience in the pharmaceutical and biotech industries.
Prior to joining SELLAS, Dr. Torre served as Vice President, Worldwide Regulatory Strategy – Global Established Products at Pfizer, Inc. Prior to this, he was Vice President of Drug Development at Elusys Therapeutics Inc., and served as Pharmaceutical Science and Legal Consultant at Axiom Law/The Torre Group. Previously, Dr. Torre held senior positions at Alvogen, including Vice President, Regulatory Affairs and Quality; Chief Compliance Officer, and Intellectual Property and Regulatory Council. Prior to joining Alvogen, Dr. Torre was the Senior Vice President for Regulatory Affairs, Quality and Technical Operations at NPS Pharmaceuticals, and he also held positions at MannKind. Prior to this, at Biovest, he was instrumental in developing FDA-acceptable surrogate markers and endpoints for an autologous vaccine to treat non-Hodgkin lymphoma. During his career, Dr. Torre also held leadership positions at Bristol-Myers Squibb, Sanofi, Sankyo and Novartis.
Dr. Torre received his J.D. from Brooklyn Law School, and he is a member of the Bar in the State of New Jersey, the District of Columbia and the United States Supreme Court. He received his BS in Pharmacy from St. John's University, College of Pharmacy and Allied Health Professions and is a registered Pharmacist in the State of New York. He was also awarded an MS in Pharmacology/Toxicology and a PhD in Pharmacology/Toxicology from the same institution.
Laura M. Katz, MPH, VP, Clinical Operations & Biostatistics
Laura M. Katz, MPH, is the Director of Clinical Operations & Biostatistics at SELLAS Life Sciences Group. Laura brings extensive experience in clinical development and clinical and statistical consulting in the pharmaceutical and biotechnology industries.
Prior to joining SELLAS, Laura served as Senior Clinical Project Manager/Senior International Manager at Novo Nordisk in the biopharmaceutical group, where held leading roles on global teams with responsibility for international management of clinical trials in Phases II to IV. Laura was also responsible for the oversight of clinical activities across multiple portfolios in pediatric and adult populations, and directed trials out of both the US and European offices. Previously, Laura served as Associate Director of Biostatistics and Clinical Project Management at Accentia Biopharmaceuticals and as a Consultant at Analytica International and Columbia University.
Laura holds a Master of Public Health in Epidemiology and Biostatistics from Columbia University and a Bachelor of Science in Biostatistics from Cornell University. She has published in prominent journals including the American Journal of Hematology; the American Journal of Public Health; the Journal of the American Academy of Child and Adolescent Psychiatry; and the Annals of Allergy, Asthma, and Immunology.
David Moser, JD, VP, Legal Affairs
David Moser is VP of Legal Affairs at SELLAS Life Sciences Group. Mr. Moser has extensive experience in the biopharmaceutical industry spanning all fields of legal involvement.
Prior to SELLAS, Mr. Moser served as Director of Legal Affairs and Secretary of BioVest International, Inc. a subsidiary of Accentia Biopharmaceuticals, where he was responsible for the SEC reporting management for two public biotech companies, documentation and closing of multiple rounds of Private Placement financing, in-house legal oversight of all agreements, S-1 and S-3 drafting, IPO closing, insider trading compliance manager, negotiation, drafting and administration of contracts and more. He also has previously worked in brokerage, civil litigation and general corporate law.
Mr. Moser received a BA degree in Political Science & Economics from Columbia University, New York, and a JD degree from Harvard Law School, Cambridge, MA.


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Al Arab News Channel: 2 Secretaries/ Administrators needed – Limassol
Vacancies have been filled
|Company name:
|Al Arab News Channel
|Mesa Geitonia Limassol
|Contact person:
|Joanna Lambri
|E-mail address:
|Job title :
|Secretary / Administrator
|Job description:
|Al Arab News Channel, a 24hr Arabic News station, dedicated and focussed on events occurring not only in the Middle East, but also worldwide, is looking to hire experienced and dedicated professionals for their new operations to be based in Limassol Cyprus.
JD – Secretary:-
A secretary provides both clerical and administrative support to the Executive Manager of HR and Admin, Employee will either be as part of a team or individually. The role plays a vital part in the administration and smooth-running of businesses. Secretaries/administrators are involved with the coordination and implementation of office procedures and frequently have responsibility for specific projects and tasks and, in some cases, oversee and supervise the work of junior staff.
Common tasks include:
1) word processing;
2) audio and copy typing;
3) letter writing;
4) dealing with telephone and email enquiries;
5) creating and maintaining filing systems;
6) scheduling and attending meetings, creating agendas and taking minutes – shorthand may be required;
7) keeping diaries and arranging appointments;
|Number of persons required:
|Qualifications required:
|In order to be successful in this role, you will need to be a keen multi tasker and able to take a hands on approach to make sure that everything is running smoothly at all times. Working to strict time constraints and showing dedication and working well under pressure are also good personal traits required for the role.
Excellent knowledge of the English language both written and spoken are an absolute must.A very attractive remuneration package is on offer to successful applicants, including an excellent rate of pay and a very comprehensive medical insurance scheme.
|Other requirements:
|Please send your CV to firstname.lastname@example.com . All applications shall be treated with complete confidentiality.
Although we aim to reply to all applicants, due to the large volume we receive, this is not always possible, however we thank you for your interest in our company and wish you all the very best of luck in your search.
|Employment conditions:
|Full Time
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Science - Earth
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Tracking Earth's Past Magnetic Moments
Science / Earth
Tuesday March 14, 2017
The key to understanding Earth's prehistoric magnetic field lies hidden in the rocks. Specifically, igneous rocks, basalts that cooled from liquid magma spewed out of volcanos. Geologist Lisa Tauxe of the University of California, San Diego, and her team, traveled to Antarctica to collect rock samples that can tell them more about the planet's magnetic field over the past few million years. The research was funded by the National Science Foundation, which manages the U.S. Antarctic Program.
The Polar Geospatial Center
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Wednesday November 30, 2016
The icy surface of Antarctica is a dynamic environment; and conditions can change drastically from year to year or even week to week. Because of these endless changes, making a map of the ever-changing ice cover can be like putting together a map of the clouds. The Polar Geospatial Center has been using satellite data to provide invaluable, up-to-date information about surface conditions across the continent for nearly a decade.
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Lawrence Benjamin, chief executive of sweeteners group NutraSweet, replaces Jim Miller, who quit in May. Foodservice is the second-biggest supplier of food to hotels, schools and caterers.
Earlier this month, Ahold reported a e3.2bn (£2.2bn) write-down, mainly due to overstated profits at Foodservice.
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Looking for a full time web designer in Pune
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Summary: What does Jessica think when she stumbles upon a wedding invitation during the course if a "normal" day? What is Mike thinking during the wedding, when Jessica is his date? Hilarity ensues when someone decides to stalk the Cullen house, looking for revenge. R & R
Chapter one: Outfits and invitations
A.N. Whenever there is a spelling mistake in this chapter, it is intentional. Like with her shoes, it's that way on purpose.
I skipped out of my parent's old, delopadated house in my sad hometown of Forks.
Awww man. Those prep classes were really helping surpass my already superior intelligence. I guess it was worth losing the nose job.
I mean, Gawd! I didn't have the perfect nose, but neither did Bella, and Edward still likes her doesn't he? My guess was that he liked his girls smart and sweet.
Lauren got a nose job, but her bleached hair obviously keeps the facts out of her brain. Edward has always hated her, she's a bitch and a ditz, plus that "visionary" haircut makes her look like a clown.
I snickered. 'Bitch Ditz.' I am too funny.
"Yaaahh!" I yelped, suddenly finding myself lying facedown on my parent's driveway. How embarassing! I quickly hopped up and smoothed out my simple, yet fashionable hot pants and punny tee, looking around to make sure no one saw that.
It seems as if no one did, so I checked my clothes one more time, just to make sure nothing was wrong. Money was tight, seeing as where I had applied to college, and I couldn't afford any new clothing or accessories.
My 'BCBG' knockoffs looked so real that even the Great Alice Cullen wouldn't be able to tell the difference. Unless she saw the tag, conviently reading 'BCBD.'
My shirt today was hilarious. It was a light grey, short sleeve t-shirt that said "Dracula Sucks." It looked like it was written in blood, and there was a picture of the actor below it, along with a few strategic rips. Punny, indeed.
I had on some blood red high heels to match the shirt that I bought from a street vendor in Port Angeles. The best part-THEY WERE REAL MARC JAKKOBS! I could not believe the deal I got. The vendor only charged me $125 dollars, while retail was at least three hundred.
All in all, the perfect look for me to go and talk with Edward. Sexy, yet smart and sweet. Perfect.
You see, a few months back, while we were still in high school, I heard from Lauren who heard from Tyler who heard from Mike who heard from Ben who heard from Angela who had heard from Bella herself, that she and Edward would both be, along with the rest of his family, attending Southeast Alaska University in the Fall.
The first thought on everyone's mind, naturally, was why? Bella hated the cold, and Alaska was twice as cold as Forks. Then, I realized what this would mean for me. I had applied to a party school in Florida, hence the new warmer wardrobe, but that would mean I would be all the way across the country from my beloved Edward. If that be the case, before I could do anything to make him finally acknowledge our mutual love, the little skank would have just sunk her claws in deeper.
That's right. You heard me. The bitch would have tricked him into marriage!
She would probably make up some ridiculous story about an unexpected pregnancy, and my sexy little Edward would feel so horrible, he would propose. I mean, that's what I would do if I was her, and we all know about the little weekend trips that they had. I'm not stupid. She would, coincedentally, "lose the baby." His Father is a Doctor, it shouldn't be that hard to convince them.
So I went and . . . Payed a visit to my old friend Mike.
Once I had convinced him, more or less, he agreed to help me. It seems as if my ex was equally disheartened by the news. It was obvious to anyone that he was completely obsessed.
Well, except to himself.
He had been accepted into the University of Seattle, but once he heard my plan, his changed dramatically.
We both applied to the University of Alaska, and we both got in.
The plan was to try and break the happy couple up as much as possible in Forks, then crush them in college.
And it would work. Mike would finally get Bella and my prescious Edward would at last be free of her. All would be happy, starting with my visit to Edward today.
Seduction was always one of my stronger points, not to braaaggg or anything.
Oh who I am I kidding! No one could resist my powers. Bella and Edward would never know what hit them.
Finally remembering why I even wasted the time to walk outside in the first place, I ended my ginormous rant, and went to grab the mail.
There wasn't that much. Looking through the stack quickly appeared to show housing bills, credit card bills, and student food plan bills. I smirked.
Allllllllllll me.
At the bottom of the stack was an envelope that was certainly not a bill. It was thick and stiff and expensive looking, adressed to 'Miss Jessica Stanely and Family.'
I quickly ran the way up the driveway and threw all the bills on our orange kitchen counter. Taking the thick one, I ran to my room and flung it on my bed, preparing to open it.
It was firstly addressed to me, right?
Following it's movements, I bounced onto the fluffy pink canopy bed I've had since I was nine. I always wanted to be a princess. Hmmmm. . . King Edward and his beautiful Queen Jessica with their adorable son, Prince Jasper Xavier and lovely Princess Esmerelda Daniellienda. I have such a way with names.
I wanted to be mindful of the paper, seeing as how it felt more expensive than my shoes, which was saying a lot.
But hell, when am I ever mindful of anything?
I ripped that sucker open faster than the time I had gone with Mike to Lookout Point and we had, ahem, "parked."
It read as so,
'You have been cordigially invited to the union of marriage of the children of:
Carlisle and Esme Cullen
Charles Swan and Renee Dywer
On the
date of August the
Thirteenth, two thousand and six
At the Cullen Estate
May God bless Edward and Isabella's souls for all of eternity'
Oh, that was nice. A wedding. I haven't been to a wedding sin--
Wait. Wait one second and Back. It. Up.
I quickly picked the invitation back up off where it had settled on the floor and read it again.
Yes, yes, Cullen, Swan, August. There. There it was. '--Edward and Isabella's souls for all of eternity.'
"WHAT!" I shrieked.
When did this happen?! That us supposed to be ME on that invitation! My name! Soon-to-be-Mrs. JESSICA Cullen.
Not Isabella. Sneer.
My plan. My future. My Edward. It was all supposed to be mine! And today was the day I was going to get it allllll! Not lose it!
What. The. Fuck.
Today was not going good for me. First, I fall flat on my face, almost ruining my new outfit, put together especially Edward.
Now! They're getting married. Sneer.
I have to stop this!
I have to.
A.N. Hope you liked first chapter. I am very interested in this story, so expect frequent updates. Next chapter-still Jessica, bit she confronts B/E and Mike. Ooooh. Stay tuned for the drama.


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An introduction to maximum parsimony and compatibility
Trevor Bruen PhD Candidate McGill Centre for Bioinformatics
Overview The point of this talk is to give a sense how discrete mathematics enters into phylogenetic and genetic inference. I will illustrate these ideas by describing two approaches in detail namely maximum compatibility and maximum parsimony. I will also show how ideas from these two criteria can be used to develop applications such as bounds and tests for recombination. My goal is to give the basis for further study in this type of area and to give greater insight into these methods.
Outline Introduction to compatibility and parsimony
Overview of basic notation/concepts Compatibility Compatibility as a graph theory problem Compatibility for pairs of characters Interpretation of compatibility Parsimony Parsimony score with connections to graph theory Connections between parsimony and compatibility Homoplasy Parsimony for pairs of characters Connections between SPRs/TBRs and parsimony Applications to recombination Parsimony as a consensus method
Introduction Maximum parsimony and maximum compatibility that are used in phylogenetics, linguistics and population genetics Phylogenetics goal is to infer an evolutionary tree Linguistics often the same Population genetics uses compatibility for recombination For general phylogenetic inference with molecular data, likelihood (probability based) methods are generally preferred. BUT compatibility and parsimony are computationally tractable. ALSO the mathematics behind parsimony and compatibility is very well developed. We can show that parsimony=likelihood in certain circumstances (Tuffley and Steel 1997). This gives us insight in where to go in terms of research.
Formalism A character is a mapping from a set of taxa to a set of states. In this case, X={S1,S2,S3,S4} Also, C={A,C} Informally, a character is a "column" in a multiple sequence alignment
Binary Character / Splits
If character has two states then it induces a split of the taxa set. Example: Let X be the taxa set {S1,S2,S3,S4}. Let C be the state set {A,C}. Then {S1,S2} | {S3,S4} is the split induced by the first character. In general a character induces a set of equivalence classes
Tree and Labeling Informally we would like to be able to mathematically describe a tree and a labeling structure. In graph theory a tree T=(V,E) consists of a graph with no cycles. Informally, we would also like to be able to add taxa (members of X) to our tree (actually the leaves). Define a labeling function (such that leaves of V(T) are labeled by members of X):
X-Trees An X-tree consists of pair: (T, phi) where phi is a labeling function that labels the leaves of T. Recall:
Extensions Informally, we have an X-tree consisting of the pair (T,phi). We also have a character chi. We need to relate the character to the tree. Define an extension of character as a function (which is consistent at the leaves with chi): Informally, an extension provides a description of how the internal vertices are labeled.
Quick Summary Summary so far:
X-tree are trees along with functions labeling the leaves with members of X A character is a function from X into a state set C An extension is a labeling of the vertices of T with states of C
Compatibility - Definition
A character is compatible with a tree if and only if there exists an extension of the character to the tree so that the subgraphs induced by each of the states are connected. Example: First tree character is compatible with tree Second tree character is incompatible since both A's are disconnected
Compatibility Problem definition: Given a sequence of characters
determine whether there exists a tree on which all character are compatible. Related problem: Given a sequence of characters determine largest set of characters that are compatible with some tree
Intersection Graph Suppose we have sequence of characters where
Then each character induces a partition of X - I.e. Create a graph where the vertex set consists of There is an edge between two vertices iff only the intersection of the two subsets are non-empty
Intersection Graph To figure out whether the sequence of characters
are compatible, we will be able to determine this directly from the intersection graph. First we need to define two concepts: a chordal graph and a restricted chordal completion of the intersection graph.
Chordal Graphs A graph G=(V,E) is chordal graph if every cycle with at least four vertices contains a chord (an edge connecting two non-consecutive vertices). A chordalization of graph is a graph G'=(V,E') where such that G' is chordal
Restricted Chordal Completions
Imagine the vertices of our graph G=(V,E) are colored. Then a restricted chordalization of G is a graph G'=(V,E'), where G' is chordal but all edges of G connect vertices of different colors.
Restricted chordal completions
A restricted chordal completion of the intersection graph is a chordalization where there is no edge between vertices that share the same character. In this case, the "colors" correspond to characters
Main Theorem for Compatibility
Let be a collection of characters. Then is compatible if and only if there is a restricted chordal completion of the intersection graph.
Pairs of Characters A simple corollary of main theorem arises when we restrict our attention to two characters. Corollary: Two characters are compatible if and only if the intersection graph, G for both characters is acyclic Proof: (backwards direction) If graph is acyclic then it is chordal so the characters are compatible. (forward direction) OTOH Suppose G contains a cycle. Then any chordal completion of G must contain a three cycle. But no restricted completion of G can contain a three cycle! So G is acyclic.
Interpretation Recall: a set of characters are compatible with a X-tree if and only if there exists an extension of the character to the tree so that the subgraphs induced by each of the states are connected. Informally speaking this is a very strict condition. This corresponds to an "all or nothing" condition - either a character is compatible with a tree or it isn't. Relaxing this condition is the subject of the next section.
Parsimony Informally: given an leaf labeled tree and a character, how can we define the fit of the character to the tree? Consider a character, along with an extension to a leaf labeled tree. Then the length of the extension is the number edges where Define the parsimony score of a character on a tree as the length of a minimal extension of the character to the tree. Denote this value by
Parsimony Then the maximum parsimony score for a set of characters
on a tree is defined as: The tree that minimizes this score is referred to as the maximum parsimony tree.
Parsimony and graph theory
A minimal cut-set for a leaf-labeled tree T=(V,E) and a character is a minimal set of edges whose removal ensure that if that x and y are in different components. Claim: There is a bijection between the set of minimal cut sets and minimal extensions. So the cardinality of the minimal cut set is equal to the parsimony score.
Parsimony and Graph Theory
Recall Menger's Theorem (1927): Let G=(V,E) be a graph with V1 and V2 as two disjoint subsets of V. Then the minimum number of edges whose removal from G leaves vertices of V1 and V2 in different components is equal to the maximum number of edge disjoint paths between V1 and V2. Corollary: For a binary character, the maximal number of edge disjoint paths corresponds to the parsimony score.
Compatibility and parsimony
Recall: let be a collection of characters. Then is compatible if and only if there is a restricted chordal completion of the intersection graph. Question: How can characterize parsimony with respect to an intersection graph?
Compatibility Graph Recall: Each character induces a partition of X - I.e. A block for a character is a subset taxa on which is constant. Thus we may identify the blocks of with the vertices of the intersection graph.
Character Refinement A character refines another character if implies
Thus characters that refine other characters correspond to refinements of the partition
Compatibility and Parsimony
Recall: Let be a collection of characters. Then is compatible if and only if there is a restricted chordal completion of the intersection graph. Main:
Special Case: Two characters
Recall: Two characters are compatible if and only if the intersection graph, G for both characters is acyclic Using the previous theorem we can show that the parsimony score for two characters corresponds to: where k is the number of components in the graph. Note: This score corresponds to the maximum parsimony score over all trees.
Homoplasy Recall: The parsimony score of a character on a tree, corresponds to minimum number of changes of a character on a tree. Informally: What is an intuitive way to think about the parsimony score? Define the homoplasy of character on a tree as
Homoplasy Note that with equality if and only if is convex on T
Informally: Homoplasy corresponds to the number of "extra" mutations of the character on the tree. These "extra" mutations correspond to recurrent mutations Informally: Thus a character is not compatible on a tree iff it cannot be placed on a tree without "extra" mutations.
Homoplasy For Two Characters
Recall: The parsimony score for a pair of characters can be found directly from the bipartite intersection graph. Recall: This score corresponds to an optimum over all trees. Thus for two characters, we can define a pairwise homoplasy score as Recall: Up to now homoplasy refers to "extra" mutations on a tree.
A second look at homoplasy
Example: Two characters with a pairwise homoplasy score equal to one. Informally: We have seen that the homoplasy corresponds to the number of "extra" mutations on a tree. But in certain situations, this is biologically implausible. The state 1 may correspond to a mutation that has only arisen once. In this case, the fact that the pairs of characters are incompatible can be explained by a recombination event. This will be defined more precisely later.
A quick aside - tree distances.
Differences between leaf labeled trees can be defined using various metrics - e.g. Subtree Prune and Regrafts A "subtree prune and regraft" corresponds to a specific re-arrangement of a tree. For two leaf-labeled trees, dSPR(T1, T2) is minimum #SPRs between T1 and T2
Homoplasy for two characters
Theorem: If and are two characters then corresponds to the minimum number of SPRs from any leaf-labled tree on which is compatible to any leaf labeled tree on which is compatible! Informally: Thus we have a whole new interpretation of homoplasy.
Application - Testing for Recombination
If recombination has occurred sites will have different histories Nearby sites will tend to have "greater" genealogical correlation than distant sites Idea: If recombination has occurred, genealogical correlation will be partially reflected by a tendency for pairs of closely linked sites to have than less homoplasy than distant sites
Test for Recombination
Idea: We would like to distinguish between two possibilities - recurrent mutation and recombination. Idea: Use previous observations to develop test for recombination. H0: Single history describe all sites. H0 ' : Nearby sites share no more compatibility than arbitrary pairs of sites Use statistic to capture information and solve analytically for p-values
Application: Parsimony and supertrees
Supertree: MRP - parsimony with characters that represent trees. What does homoplasy mean in this context? Courtesy of TREE 12:
Parsimony as a consensus tree
Recall: If and are two characters then corresponds to the minimum number of SPRs from any leaf-labeled tree on which is compatible to any leaf labeled tree on which is compatible. Informally: This can be generalized to show that the maximum parsimony tree for a set of charaters minimizes the SPR distance to each of the set of tree on which each character is compatible…
Acknowledgements Thanks for listening! Background and further reading:
Phylogenetics, Semple and Steel (book 2003) Some results I presented are not on this book - they are from work I have worked on. Please talk to me if you are interested. I have many other references- please see me if interested.
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The banknote printer De La Rue has said that the weak euro had handed its European competitors a price advantage as it revealed sharply lower annual profits.
Its shares dropped by 9 per cent as De La Rue revealed that pre-tax profits nose-dived by 35 per cent to £38.9m in the year to March on revenues down from £513m to £472m. It is cutting its dividend by 41 per cent to 16.7p.
Martin Sutherland, De La Rue's chief executive, said profits were being hurt in the short-term as competitors benefited from the weak euro.
"These results are in line with our revised expectations and include the benefit of further operational efficiencies," he said. "However, these have been outweighed by the impact of the challenging market conditions."
Jobs cuts at its Overton and Gateshead plants have helped make £7m savings.
While pricing pressures hit its banknote printing business, which prints 150 national currencies, returns at its microchip and passport processing systems unit were "lower than expected".
Mr Sutherland, who was presiding over his first full-year of results, faces a stiff challenge in turning around the business, which has issued three profits warnings in the past two years.
Mr Sutherland, who previously ran BAE's cyber business, said: "I have completed a review of the business and formulated a clear strategic plan to deliver growth and improve profitability in the long term."
De La Rue has won a 10-year contract with the Bank of England to print sterling at the Bank's printing plant at Debden in Essex.
This includes next year's new notes featuring Winston Churchill and Jane Austen.
Its shares fell by 49.5p to 504p.Reuse content


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:)<quoted text>Bwaaahahahaha You got that right baby I might be getting along in the years but I would absolutely turn her every which way but loose.
Right turn Clyde.
Mercy, mercy miss Percy, I'd love to be behind the bushes when she took that midnight dip.
Hundreds of birds die in western Ky.
There are 81698 comments on the The Cincinnati Enquirer story from Jan 5, 2011, titled Hundreds of birds die in western Ky.. In it, The Cincinnati Enquirer reports that:
MURRAY, Ky. - State wildlife officials say "several hundred" dead birds were found near the Murray State University campus last week.
Join the discussion below, or Read more at The Cincinnati Enquirer.
#89451 May 15, 2013
#89452 May 15, 2013
You stay busy I know and that is good for your heart and soul with your work on the homestead, your chickens, helping neighbors, your boys, and those ladies you go see with the eggs. You have date nights and stay active on a level I will eventually get to. You are right that sitting around was the worst. You can only clean house and work in the yard for so long and all my family and friends were always at work. Since I don't have any grandchildren I had too much time on my hands. I decided to go work 5 hours a day for something to do and make some new friends. Plus, add a little to that retirement check I earned. Who can't use extra money huh? I bet you put that Stetson hat on and two step now and then don't you? I can see you doing that. You aren't over the hill yet, and when you get there you will enjoy the view at your family homestead you worked so hard to get and make your own. You need to send us some new pictures. OJG too!
Hope you enjoyed the beautiful day!
#89453 May 15, 2013
Off to dreamland. I hope you had a great day. Sorry I missed you guys. Check with you tomorrow.
Sweet dreams!!!
"Is who I am"
Since: Aug 08
#89456 May 16, 2013
Well, cloudy this morning. Hope the rain holds off for just a bit. Hope you all have a good day!! Got to go feed the birds!
#89458 May 16, 2013
Moratorium here?
"Is who I am"
Since: Aug 08
#89459 May 16, 2013
It's been kinda dead in here today I see.
I guess with this nice weather, people had to be outside in it. I was too. Mowed my lawn with the push mower and threw out my back. LOL!!
#89460 May 16, 2013
O no, hope you're okay. I fell assbackward on a large stone. Kids across the street must've thought I was drunk. Your back, my hip. Is it something about getting older you reckon? or maybe were too vigorous;) Lol. Rained here. Will get mine in a few days.
Since: Mar 11
Location hidden
#89461 May 16, 2013
Good evening, my fine feathered friends. I will never consider myself over the hill. When you get to the top, and make your way down, you find that there is always another hill to climb. Staying physically active is always important, but the key is to stay mentally active. If you can manage that, you have conquered getting old.
#89462 May 16, 2013
my peas have little white flowers on them now...... right on schedule (i think) and i think i should be harvesting in another two or three weeks..... beans are about a week behind thanks to the late frosting we had but they are getting there... and coming back stronger than they were.
hubby registered for his summer and fall classes:
math 110 and keyboarding this summer, then in he fall he is taking another keyboarding, intro to something (idk), writing 101, and war of the worlds.... he is really excited about that last one lol. if they gave out credit hours based on much much your nelson box says you watch the military channel and history channel.... he would have a degree by now.
very proud of him :)
#89463 May 17, 2013
Two older men repaired siding on an old lady's house yesterday and she fixed us a really great chicken pot pie for our pay. The best part is that the IRS don't get any of it. LOL
How can I NOT stay active? Too many people need me to stop and the CREATOR lets me keep going for now. If the rains hold off, I will be mowing again today. I had planned to mow yesterday until I found out that the old lady needed help.
#89464 May 17, 2013
The more of those blackbirds gone, the better.
"Is who I am"
Since: Aug 08
#89465 May 17, 2013
Well, here comes the rain! Glad I got the lawn done for the most part. Durn head cold is killing me though. I have NO clue where it came from, but I wish it would go away!
#89466 May 17, 2013
Could it be Paradise coal? That coal burn off has been around for many years now.
"Is who I am"
Since: Aug 08
#89467 May 17, 2013
It could be a lot of things that kill the birds. We may never really know.
Since: Nov 12
Location hidden
#89469 May 17, 2013
We helped a lady out for years after years, she and her sisters and
in-laws stuck us with 30,000 dollars.
Since: Nov 12
Location hidden
#89470 May 17, 2013
Just don't watch the poor birds die. Speak up!
"Is who I am"
Since: Aug 08
#89471 May 17, 2013
I, personally haven't seen anything, but who should I speak TO exactly?
United States
#89472 May 17, 2013
#89473 May 17, 2013
You are not that old AW, and I hope you don't think I was implying you were. I am just not at the stay at home stage you are and you are not that far ahead of me. I know you are a good looking man and with that stetson hat those ladies couldn't resist you either. Any one of them would be lucky to have time with you. You know how your email fan club feels about you. Right, lala?
Bet that pot pie was better than KFC could offer. Hope you got to mow today before the rain set in. It has just sprinkled here off and on.
#89474 May 17, 2013
Speaking of KFC, did you all see this on the news..haha
KFC smuggled through tunnels to Gaza 'dream come true'
In a testament to the Colonel's power, a fast food smuggling service sneaks KFC all the way from Egypt to the Gaza Strip for customers who pay triple the price just to get their hands on those secret herbs and spices. The 35-mile long journey through underground tunnels takes three hours from the Al-Arish KFC to Gaza and the company who supplies this vital service advertises, naturally, on Facebook. "It has been a dream, and this company has made my dream come true," said happy customer Rafat Shororo, an accountant who had tasted KFC in Egypt six long years ago and lusted for it ever since.
News video is great, this is what was on the news:
KFC smugglers deliver fast food the hard way
KFC meals are being ordered from Egypt and delivered via smuggling tunnels to the besieged Gaza Strip. Lily Grimes reports.
That is too funny.
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Evaluation of the Antibacterial Activity of the Traditional Medicinal Plant, Astragalus membranaceus Katrina Cheung Biology Department, Skyline College, San Bruno CA Acknowledgements Dr. Christine Case, Skyline College Professor of Biology Patricia Carter, Skyline College Biology Lab Technician Stephen Fredricks, Skyline College MESA Director Ken Louie, Chinese Herbalist Casey Fortier, Skyline College Student Researcher Skyline College SACNAS Chapter Literature Cited 1.Cowan, M. 1999. "Plant Products as Antimicrobial Agents" Clinical Microbiology Reviews 12(4): 564-582. 2.Tan, B. et al. 2004. "Immunomodulatory and antimicrobial effects of some traditional Chinese medicinal herbs: A review" Current Medicinal Chemistry 11: 1423-1430. 3.Yu, Q. et al. 2007. "Determination of seventeen main flavonoids and saponins in the medicinal plant Huang-qi (Radix Astragali) by HPLC-DAD-ELSD" Journal of Separation Science 30: 1292-1299. 4.Ma, X. et al. 2002. "Chemical analysis of radix Astragali (Huangqi) in China: A comparison with its adulterants and seasonal variations" Journal of Agriculture and Food Chemistry 50: 4861-4866. 5.Gao, X. et al. 2009. "Saponin fraction from Astragalus membranaceus roots protects mice against polymicrobial sepsis induced by cecal ligation and puncture by inhibiting inflammation and upregulating protein C pathway" Journal of Natural Medicines 63: 421-429. 6.Wong, C. et al. 1988."Immunotherapy with Chinese medicinal herbs II. Reversal of cyclophasphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo." Journal of Clinical Laboratory Immunology 25: 125-129. 7.Xu, H. et al. 2007. "Effects of Astragalus polysaccharides and astragalosides on the phagocytosis of Mycobacterium tuberculosis by macrophages" The Journal of International Medical Research 35: 84-90. 8.Louie, Ken. Chinese Herbalist. Personal Interview. 2 February 2010. 9.Mead P. et al. 1999. "Food-Related Illness and Death in the United States." Emerging Infectious Diseases 5(5): 608-625. Methods Extract Preparation 1.Dried root of Astragalus membranaceus was obtained from Mt. Hengshan, Shanxi province (China). 2.Root was ground into fine pieces using scissors, mortar, and pestle. 3.Ground root was mixed with alcohol (95% methanol or 95% ethanol), to a final concentration of 143 mg/mL. 4.Mixture was heated to boiling (65°C or 78°C) for 60 minutes, to a final concentration of 166.67 mg/mL. 5.Root extracts were filtered through two layers of cheesecloth and then dried by evaporation. Well Diffusion Assay 1.Nutrient agar or Tryptic soy sgar plates were inoculated with test bacteria: Escherichia coli (ATCC 11775), Staphylococcus aureus (ATCC 27659), Mycobacterium phlei (Wards 85 W 1691), and mannitol-positive, coagulase-positive staphylococci isolated from human skin. 2.6-mm wells were made in the agar with a cork borer. 3.Wells5 were filled with 40 µL extract or solvent (negative control). 4.Antibiotic disks were placed on each plate as positive controls. Penicillin and Streptomycin, 10 µg/disk (Hardy Diagnostics) 5.Plates were incubated at 37°C for 24-72 hours. Minimal Inhibitory (MIC)/Bactericidal Concentration (MBC) 1.Serial dilutions (166.67-16.67 mg/mL) of extracts were made in sterile water. 2.Dilutions were placed in separate wells in a tissue culture plate along with nutrient broth or tryptic soy broth. 3.Each set of dilutions were inoculated with E. coli, S. aureus, or M. phlei and incubated for 24-48 hours at 37°C. 4. Dilutions with no growth were then subcultured. Bacterial Growth in Cottage Cheese 1.10 g cottage cheese was placed into sterile Petri dishes. 2.Two plates were inoculated with 100 µL of a 24-hour E. coli culture and two plates with 100 µL of a 24-hour S. aureus culture. 3.Methanolic extract (16.67 mg/mL) was added to one plate of each organism. 4.Plates were incubated at 37°C for 25 hours. 5.Plate counts were used to determine the number of bacteria. Results 1. Alcoholic extracts of A. membranaceus inhibited gram-positive (S. aureus and M. phlei) and gram-negative (E. coli) bacteria. 2. The MIC and MBC against these organisms were determined (Figure 1). 3. The inhibitory effect of the ethanolic extract against S. aureus is comparable to that of a 10-µg streptomycin disk (Table 2). 4. The extracts were especially effective against M. phlei (Figure 2, Table 2). 5.The ethanolic extract is 50% more effective at inhibiting E. coli than a 10-µg penicillin disk (Table 2). 6. The bacterial doubling time in the control cottage cheese was 30 min. The death rate of S. aureus growth in the methanolic extract-cottage cheese was 13 min (Figure 3). The death rate of E. coli in the methanolic extract-cottage cheese was 46 min (Figure 4). 7. Both alcoholic extracts inhibited S. aureus harvested from human nose and ears (Table 2). Discussion & Conclusions 1.Mycobacterium is difficult to kill because of the cell wall mycolic acids. Low concentrations (33.33 mg/mL) of both alcoholic A. membranaceus extracts were bactericidal against M. phlei. 2. Traditional medicine utilizes A. membranaceus to treat patients infected with M. tuberculosis. Further testing needs to be done to determine whether A. membranaceus is bactericidal against M. tuberculosis, and whether it can be used to treat multi-drug resistant M. tuberculosis. 3. E. coli is a causative agent in foodborne illness (9). The methanolic extract significantly decreased E. coli growth in cottage cheese (Figure 3). 4. S. aureus is a common cause of foodborne intoxication (9). The methanolic extract prevented growth of S. aureus in cottage cheese (Figure 4). 5. There is potential for alcoholic A. membranaceus extract to be used as a disinfectant, a food preservative, and tuberculocide. Figure 2. Ethanolic Astragalus extract strongly inhibited the growth of M. phlei. Control well contains 95% ethanol. Penicillin disk (10 µg) had no effect on M. phlei growth. Background 1.Humans have used plants for medicinal purposes since the Neanderthals, 60,000 years ago (1). 2.The use of Chinese plants as medicine is believed to have first started over 4000 years ago during the Xia dynasty (2). 3.Astragalus membranaceus (Figure 1) is utilized by Chinese herbalists to treat a variety of infections (2,6,8). 4.Previous studies have shown that the plant has immune-enhancing effects (6). 5.Four medicinally beneficial components can be separated from the plant: flavonoids, saponins, polysaccharides, and gamma amino butyric acid (3,4). 6.Observed success of A. membranaceus against a number of infections in vivo has been attributed to the saponin component (5,7). 7. Five different A. membranaceus saponins (AMS) can be extracted from the root of the plant using methanolic and ethanolic solvents (3,4). 8. A. membranaceus is used to treat Mycobacterium tuberculosis in China. AMS has been shown to have macrophage-promoting effects in tuberculosis patients (7). Abstract Astragalus membranaceus (Fabaceae) is commonly used in Chinese medicine to treat a wide variety of infections. However, there is a lack of information on the effectiveness of A. membranaceus against microorganisms. The purpose of this research is to determine whether A. membranaceus inhibits bacterial growth in vitro. Methanolic and ethanolic extracts were prepared using dried root from Mt. Hengshan, Shanxi Province (China). The extracts were heated to boiling, dried by evaporation, and resuspended in sterile distilled water. The 167-mg/mL extracts were tested in well diffusion assays against gram-negative Escherichia coli and gram-positive Staphylococcus aureus and Mycobacterium phlei bacteria. Both alcoholic extracts inhibited bacterial growth. The inhibitory effect of methanolic Astragalus extract against gram-positive organism is comparable to streptomycin (10 µg disk). The ethanolic extract is 50% more effective at inhibiting E. coli than penicillin (10 µg disk). Microdilutions were performed to determine the minimal inhibitory concentrations and minimal bactericidal concentrations of the methanolic Astragalus extract against E.coli (150.00-mg/mL, 166.70-mg/mL), S. aureus (83.33- mg/mL, 166.700mg/mL), and M. phlei (16.67-mg/mL, 33.33-mg/mL). The minimal inhibitory concentrations and minimal bactericidal concentrations of the ethanolic Astragalus extract against E.coli (100.00-mg/mL, 116.67-mg/mL), S. aureus (50-mg/mL, 100-mg/mL) and M. phlei (16.67-mg/mL, 33.33-mg/mL) were determined using the same technique. Methanolic Astragalus extract inhibited the growth of E. coli and S. aureus in cottage cheese. The use of Astragalus membranaceus as a disinfectant or sanitizer will be discussed. Hypothesis Extracts prepared from the root of Astragalus membranaceus will inhibit bacterial growth. Figure 1. Sliced roots of Astragalus membranaceus (huang-qi, 黃耆 ) (Fabaceae) are sold as herbal remedies. This plant is grown commercially in China's Shanxi, Gansu, and Hellongjiang provinces. Common names include locoweed and milk vetch. Table 1. MIC and MBC of Astragalus extracts Bacterium Ethanolic ExtractMethanolic Extract MIC (mg/mL)MBC (mg/mL)MIC (mg/mL)MBC (mg/mL) E. coli100.00116.67150.00166.70 S. aureus 50.00100.00 83.33166.70 M. phlei 16.67 33.33 16.67 33.33 Figure 4. Methanolic Astragalus extract (166.7 mg/mL) prevented growth of E. coli in cottage cheese. Figure 3. Methanolic Astragalus extract (166.7 mg/mL) prevented growth of S. aureus in cottage cheese. Error bars=1 S.E. Table 2. Inhibition by Astragalus extracts in the well diffusion assay. Zone of inhibition (mm) Astragalus extractsAlcohol controlsAntibiotic disks BacteriumMethanolEthanolMethanolEthanolPenicillinStreptomycin S. aureus15.020.00.0 47.020.0 E. coli 9.015.00.0 10.018.0 M. phlei27.037.00.0 10.0 Wild-type S. aureus 13.015.07.08.043.019.0 0 S.E.
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Party affiliation: Democratic Party
Joseph Christopher O'Mahoney
Son of Denis and Elizabeth (Sheehan) O'M.; student Columbia, 1905-07, LL.D., 1938; LL.B., Georgetown U., 1920, LL.D., 1941; De Paul U., 1946; LL.D., U. Wyo., 1947; D.Sc. in Bus. Adminstrn., Hill Coll., 1948; married Agnes V. O'Leary, June 11, 1913. Editor Cheyenne State Leader, 1916; began law practice at Cheyenne, Wyo., and Washington, D.C., 1920; 1st asst. postmaster gen. of U.S., 1933; U.S. senator, 1934-53, 54—. Vice chmn. Democratic State Com., Wyo., 1922-30, mem. Nat. Com., 1930-34, vice chmn. nat. campaign com., 1932. Mem. Am. Bar Assn., Phi Kappa Sigma. Catholic. Home: 502 E. 22d St., Cheyenne, Wyo. Office: Senate Office Bldg., Washington.
attended the parochial and public schools
Columbia University, New York City; moved to Boulder, Colo., in 1908 and engaged as a reporter on the Boulder Herald; moved to Cheyenne, Wyo., in 1916 and served as city editor of the Cheyenne State Leader; executive secretary to Senator John B. Kendrick 1917-1920; graduated from the Georgetown University Law School, Washington, D.C., in 1920;
- Appointed First Assistant Postmaster General in 1933, and served until December 31, 1933, when he resigned to become a Senator; appointed on December 18, 1933, as a Democrat to the United States Senate to fill the vacancy caused by the death of John B. Kendrick, and elected on November 6, 1934, to fill this vacancy and also for the term commencing January 3, 1935; reelected in 1940 and again in 1946, and served from January 1, 1934, to January 3, 1953; chairman, Committee on Indian Affairs (Seventy-eighth and Seventy-ninth Congresses), Committee on Interior and Insular Affairs (Eighty-first and Eighty-second Congresses), co-chairman, Joint Committee on the Economic Report (Eighty-first and Eighty-second Congresses); unsuccessful candidate for reelection in 1952; elected on November 2, 1954, to fill the vacancy caused by the death of Lester C. Hunt, and also elected for the full term commencing January 3, 1955, and served from November 29, 1954, to January 3, 1961; was not a candidate for renomination in 1960; resumed the practice of law in Washington, D.C., and Cheyenne, Wyo.;
bioligical mother: Elizabeth E. Sheehan
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Top seed Li Na of China won the WTA Birmingham title at Edgbaston and returned to the world's top 10 after beating second-seeded Russian Maria Sharapova 7-5, 6-1 here on Sunday.
It was a repeat of last year's semi-final, where Li also beat Sharapova before losing to Slovak Magdalena Rybarikova in the final.
In a close first set Li found herself 1-3 down but rallied before taking the second set in just 24 minutes for what was the 24-year-old's third career title.
She has also won in Guangzhou, in her native China, in 2004 and at Australia's Gold Coast two years ago.
Li was the first Chinese woman to break into the Top 10 earlier this year, reaching No.10 after a run to the semi-finals of the Australia Open, before dipping out of the elite group after a seven-week stay and dropping to as low as No.16.
But some solid performances on clay and this victory on the grass at Edgbaston, which acts as a warm-up event for Wimbledon, now the last of the four tennis Majors to be played on grass, have seen Li rise back up the global rankings.
Former Wimbledon, Australia and US Open champion Sharapova was bidding for a third Edgbaston title.
And had she won on Sunday, Sharapova would have been the first female player this year to take three tour events following wins in Memphis and Strasbourg.


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My name is Mrs Neze-Bassey from Nigeria I took a chemical called JIK thinking I was pregnant, just to abort. Please I need an advice on what to do. I took the chemical since 2010 July since then I have been trying to get a child.
Comments for Natural Fertility Drugs
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Comments are posted only after approval. For medical related questions, please talk to your health care practitioner. I will not answer questions on conventional fertility medications. If you are taking any prescription drugs for fertility talk to your doctor. With this website my job is to educate and support you in learning more about natural therapies that can help boost your fertility and prepare for a healthy pregnancy. Please do not submit medical tests or results. If you have questions on your fertility or medical results talk to your doctor. Those questions will not be answered.
Emotional Detox for Fertility
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Natural fertility expert and emotion code practitioner, Maria Gioia Atzori explains how the energy of negative emotions can affect your ability to conceive. Learn how you can release your emotional baggage to get pregnant.


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Tag Archives: health
Chia Pudding Parfait RecipeLeave a comment
January 16, 2017 by Living Girl Living Foods
These out of the mug treats are becoming more popular within the last three years or so. I have a …
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August 25, 2016 by Living Girl Living Foods
Today's post is in dedication to all of us happily overwhelmed with the bounty of tomatoes from this summers harvest. …
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I shared a Matcha post not too long ago with information on what Matcha is, where to find it, how …
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For years now the most viewed articles on this site have been; Seeded v.s Seedless Grapes , Red Beets v.s Golden …
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Did you know? Roughly 71 percent of the Earth's surface is water-covered. The oceans hold about 96.5 percent of all Earth's …
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Aopen Com4824 Driver Download
Aopen Com4824 Driver Details:
Aopen Com4824 File Name: aopen_com4824.zip
Aopen Com4824 Driver Version: 119B1
Aopen Com4824 ZIP Size: 109.kb
Manufacturer: Aopen
Scan Status: OK
Aopen Com4824 special revision for: Windows 7 Enterprise (Microsoft Windows NT) 64 bit, Windows 10 64 bit, Windows 7 Home Premium 64 bit, Windows 7 Service Pack 1 (Microsoft Windows NT) 64 bit, Windows XP Media Center Edition 2003 64 bit, Windows XP Home Edition N 64 bit, Windows 7 Ultimate 64 bit, Windows XP Professional x64 Edition 32 bit, Windows XP Media Center Edition 2005 32 bit
Aopen Com4824 Download Stats:
Direct Downloads: 104
Most Recent Download: 4/23/2017
Managed Downloads: 3062
Most Recent Download: 4/24/2017
Download Mirrors: 2
Current Delay: 15 Seconds
Driver License: GPL
Direct Download Success Stats:
Reports Issued By 78/104 Users
Success Reported By 10/78 Users
Driver Download Score67/100
Driver Installation Score68/100
Overall preformance Score72/100
Installation Manager Success Stats:
Reports Issued By 2419/3062 Users
Success Reported By 1936/2419 Users
Driver Download Score95/100
Driver Installation Score87/100
Overall preformance Score83/100
1. Direct DownloadSelect your OS and press "Download".
This option requires basic OS understanding.
Select Your Operating System, download zipped files, and then proceed to
manually install them.
Recommended if Aopen Com4824 is the only driver on your PC you wish to update.
2. Driver Installation Manager
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Automatically scans your PC for the specific required version of Aopen Com4824 + all other outdated drivers, and installs them all at once.
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Don't keep foods in the living room, bedroom, or den. Most of the seeds started growing within 20-40 days including the ones in agar. Another study on Garcinia Cambogia, this one conducted by the University of Kerala, in Kariavattom, Thiruvananthapuram, India found that the flavonoids in Garcinia Cambogia caused lower lipid levels as well as lower cholesterol. Using my DMD standard Diet Mountain Dew, this drink rates exactly the same as a small Red Bull. Imagine feeling happy, at peace, in control and energetic in your body. This is usually noticed in older adults who have diabetes and have not managed their diabetic diet very well. Effects of garcinia cambogia Hydroxycitic Acid on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial. The new diabetic diet may be the best diet for everyone even if you don't have diabetes. It is up to you if you wish to add spices and onion to the baked potato.
Every HCG diet menu has its own benefits from which you can advantage over Garcinia Cambogia 60% HCA online the time.
Locaserin break through news could be just what dieters and the doctor ordered because it looks to one of the Garcinia first 4.95 diet pills that will possibly gain FDR approval, being as strong as the now tabooed 'fen-phen' and working as quickly with the same appetite strength without the dangers and in a more natural way. Truthfully, excess weight does disappear with most diets.
Bearded dragons, which are omnivores meaning they eat both animal HCA Cambogia Garcinia elgin and plant, require a specific diet in which to function properly. The Jenny Craig company began in Australia, began offering Garcinia Cambogia HCA citrimax extract its diet pure health Garcinia Cambogia reviews funny program in America in 1985, and was purchased by Nestl in 2006. It is found to be very beneficial for improving the strength and length of bones.
All liquid food like milk, juice of vegetables or fruits, etc. Remember, you still eat foods that you like, you get cheat days, and you have your meal plans designed for you; that's why I highly recommend Fat Loss 4 Idiots as the easiest and fastest way to go in losing weight.
If you're looking for foods that cause you to lose weight, the negative calorie food diet is absolutely one that you should take a look at considering. If you have a lot of weight to lose and nothing seems to be working, try the HCG diet plan. I also don't know what would happen once a person stops taking the supplement. A low sodium diet usually allows a daily sodium intake of 2,000 mg of Garcinia Cambogia HCA elgin sodium or less, per day. But vegetables and fruits, a plant-based diet with some fish, work better to keep your arteries cleaner of fat and calcium build-up over the decades. It's probably best to wait for a day or two, then begin. They are looking for a quick fix, instead of building on development once diet is established. It takes a little more energy to digest raw foods, but it s a healthy process. It's not true that our organs want our assistance to purify the body. Try to stick to low sugar carbs and decrease on caffeine. These are the three major things that you need to consider while taking Dallas HCG diet. Remember, you should try to choose the foods you love when you are designing your own diet plan. This means that people who eat it will not store that many calories in their body making them not gain so much. Chose whole grains: Whole grains have twice as much fiber as breads made with white and refined fiber.
A diet that works just a little higher with livewell Garcinia Cambogia reviews helping individuals preserve weight off longer is the metabolic diets that you'll find available. Over the course of two weeks, gradually reduce the amount of the original diet and slowly increase Garcinia Cambogia extract 60% HCA potassium the food for the new diet. John McDougall has been studying, writing and speaking out about the effects of nutrition on disease for over 36 years. Rice, oatmeal, whole wheat pasta, and northern fruits are excellent sources. No exercise advice, no calorie or carb counting, no fuss.
They merely join in a health club and work their bodies through a tough program. These are few of the common symptoms of kidney stones. Eating foods that have some complex carbs can help reduce your tiredness and staying away from fatty foods will help with the heartburn. Only recently that it was discovered as a potential weight loss tool thus it has been studied to processed it further to become supplement and used worldwide especially on western countries where obesity is a disease. As with many leaders of public opinion, he often finds it necessary to challenge the accepted wisdom of the time, and was one of the first traditional physicians of the medical establishment to assert that adoption of a vegetarian diet can reverse unfavorable medical conditions such as heart disease. IgE vs IgG Allergy ResponsesOccasionally you might come in contact with a substance that your body tells you it doesn't like. Start your weight loss journey by eliminating some unhealthy foods from your diet. Cheese and creams will have a high unwanted fat; therefore, you should be cautious when looking for those specifically. What you are really losing during those Garcinia Cambogia with HCA initial few days is body fat but that is only because the drastic change in calorie level sends your body into starvation mode, which is when your body, without enough calories to keep you going, begins to use or burn your body fat as an energy source. Red meats, sugars, sodium and other sweets are out in this diet, while whole grains, nuts, fish and poultry are. I used to need six or seven hours and now I need four or five and am much more mentally alert." Meanwhile, celebrities such as singer Chaka Khan has credited a vegan diet for her dramatic 60-pound weight loss, and MSNBC host Al Sharpton has gushed how energetic he feels after he stopped eating animal protein. Some time ago looked at on country wide tv, Healthcare professional. So, with their editors blessing, they decided to go out and put the product to the test. Difference in ApproachOur body stores fat to protect itself from impurities. What are some of the reasons a fad diet is not good for you.
Combining this with American Ginseng has been shown to help symptoms of ADHD in children in several studies.


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Event: Vivek Oberoi alongwith wife Priyanka, Eesha Koppikhar, filmmaker Bunty Walia, Rahul Dev and many others graced A. Lange and Sohne party held at Aurus, Mumbai.
Guest List: Vivek Oberoi, Priyanka Oberoi, Isha Koppikar, Deepti Gujral, Aanchal Kumar, Juhi Babbar, Anoop Soni
Venue: Aurus, Mumbai
Date: 17-Nov-2011
Bollywood celebs Athiya Shetty, Ileana D'Cruz and Arjun Kapoor were snapped at mehboob studio.
Bollywood celebs-singers-directors Amitabh Bachchan, Abhishek Bachchan, Rishi Kapoor, Kabir Bedi, Gulzar, Saroj Khan, Subhash Ghai, Jackie Shroff, Randhir Kapoor, J.P.Dutta, Udit Narayan, Ramesh Sippy...
Bollywood actress Katrina Kaif was spotted with her family at Bandra.
Bollywood actress Tisca Chopra was snapped for 'She The People TV' book store at Bandra.
Bollywood celebs Sidharth Malhotra, Alia Bhatt, Karan Johar, Sanjay Kapoor, Punit Malhotra among others were snapped at the special screening of BAAHUBALI 2: THE CONCLUSION


text:
My wife and I opted for a couple of one day excursions with Alain in Provence. We had communicated via email prior to leaving for France and had made preliminary plans to meet in... read more
Provence tours as you wish from Avignon, Arles, Aix en Provence and...
Provence tours as you wish from Avignon, Arles, Aix en Provence and Marseille.
Provence offers a big diversity of tourist sights, an old history, culture and traditions.
We would be very happy to show you Provence and to take you to nice places and areas we just love by taking remote routes aboard a comfortable and air-conditionned minibus.
We do pick up from your hotel in Avignon, Aix en Provence, Arles... or from your cruise ship in the port of Marseille.


text:
The State Liberals are demanding that the new Chief Executive of the Department of the Premier and Cabinet Don Russell choose to either reside permanently in South Australia or resign from the high-powered position.
Read more >
Education Minister Susan Close has confirmed in correspondence to the State Liberals that the STEMWorks School Infrastructure project will see major portions of grants to schools eaten up in 'project costs', 'professional fees' and other non-building related costs.
On the second anniversary of the release of Transforming Health the State Liberals are calling on the Weatherill Government to abandon its dangerous downgrading of Adelaide's hospital network.
National data released today confirms that emergency health services in metropolitan Adelaide are deteriorating under Transforming Health.
The new Royal Adelaide Hospital lurched further into crisis today when the Weatherill Government sacked Julia Squire, one of the key project leaders.
The Productivity Commission's Report on Government Services has today revealed that South Australia recorded the second highest road death rate in the nation in 2015, only behind the Northern Territory.
State Liberal Leader Steven Marshall today announced plans to boost the South Australian economy with construction of a new heavy freight corridor and freight-only airport.
The Weatherill Labor Government's crazy shop trading laws have forced some stores to install roller doors because they are prohibited from selling some of their goods on public holidays.
Violent offenders continue to menace commuters on Adelaide's public transport network, as figures reveal weapons offences and assaults have again risen under Labor.
South Australia needs a focused state government to meet today's challenges and tomorrow's opportunities.


text:
Kokeile nopeaa ja turvallista Microsoft Edgeä, joka on suunniteltu Windows 10:lle Aloita
After his girlfriend is kidnapped, Wei must fight through an invasion of hopping vampires, demons, and the ghosts of his past who are threatening to take over the city. Luckily, Wei has new moves and weapons at his disposal to make it through this nightmare.
Luo napsauttamalla ja lähetä linkki sähköpostiohjelmallasi


text:
Or telephone ...
Rebecca Infield
0798694 8886
Friday 28 October | Time: 11am
Running time: Approximately 1 hour
Suitable for children in Years 1, 2 and 3
Tickets: Children £5 Accompanying teachers FREE
A lonely boy finds a stranded baby whale on a beach and takes it home to look after it. The heart-warming story of The Storm Whale has received huge critical acclaim and was shortlisted for the Best Books Award. Join us to discover the story behind The Storm Whale as author Benji Davies shares his love of drawing and painting and talks about his work. See Benji draw live on stage, get a sneak preview of his latest picture book, and be inspired to create your own amazing stories.
To book tickets and have the chance to claim one of our three free school workshops with Benji Davies call Rebecca Infield on 0798694 8886 or email firstname.lastname@example.com
For information about the theatre, parking facilities etc, please visit: www.curveonline.co.uk


text: Drugs for Relapse Prevention of Alcoholism by Rainer Spanagel English | 15 Dec. 2004 | ISBN: 3764302143 | 244 Pages | PDF | 1 MB Alcoholism is a pathological behavioural syndrome, characterised by comp- sive alcohol use, craving and relapses, even recurring after many years of abstinence. It is suggested that chronic alcohol abuse leads to persistent changes within several neurochemical pathways in the brain and furthermore that an imprinted drug and addiction memory may scarcely be extinguished. Buy Premium From My Links To Get Resumable Support,Max Speed & Support Me Code: Download ( NitroFlare ) http://nitroflare.com/view/6263D25C3606CFB/sllfn.Drugs.for.Relapse.Prevention.of.Alcoholism.by.Rainer.Spanagel.rar


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glass art work approx 120cmx80cm


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If you are looking for golf gifts for dad for his birthday or Christmas, you have a wide range of usual and unusual products to choose from. The obvious place to look is a general sporting goods shop that sells a range of products for all the popular sports. However, you may find that your selection in this type of store is limited, with only a small section devoted to golfing products.
Find stores dedicated to selling golfing items in close proximity or attached to popular and famous golf courses. They tend to cater for a more up-market clientele who are serious golfers. They stock well-known brands that have links to the game of golf. In addition to selling equipment, clothing and golfing memorabilia they help to promote businesses in their local area by providing them with advertising opportunities within the store. Golf is an expensive hobby and it can be difficult to find something within your budget unless you are lucky enough to pick up something suitable in a sale. The alternative is to use the internet to search for your dads present. The internet introduces you to a worldwide market place where you can source golfing products to fit your budget.
Ordering products on the internet is quite straightforward, but you will need a debit or credit card to pay for your goods. Before you place your order, check the delivery timescales to ensure you will receive it in time. If there is a delivery charge to be paid, you should compare the total cost, with buying the same item in store. Check the returns policy in case the item is damaged, or is not what you thought it would be, and you need to send it back. Whether you are buying in-store or on the internet, you can customize most gifts with a name or a message at the point of purchase. Charges for names and messages are a set cost for each letter or per phrase, and you will need to allow for the additional cost in your budget. Alternatively, you can buy a wide range of novelty gifts with printed names or messages as standard.
If your dad does not get to spend as much time on the course as he would like, a mat with accessories will allow him to practice his putting at home or in the office. This type of product allows him to practice downhill and uphill putts and improve his ability to estimate distance. For something that is going to keep him warm and comfortable on the green, there are some stylish and colorful golf shirts. The materials used for golfing shirts are lightweight, crease resistant and quick drying if they get caught in the rain. Alternatively, you can choose other items such as gloves, socks and footwear for the golf course.
In a lower budget bracket, there are novelty items that can have a practical use, such as mugs or glasses that depict golfing scenes. Alternatively, you can buy golf gifts for dad that can be shared by all the family such as a jigsaw puzzle featuring a golfing theme. There are selections of themed computer games that are fun and aim to improve golfing skills.


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Island City Picture Co. "Mom and Her Cubs" Framed Print
Item # WX2-168058
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Island City Picture Co. "Mom and Her Cubs" Framed Print. All set for a playful day in the forest!
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Serbian Association of Anti-Aging Medicine was established in 2008 as a non-profit organization based in the Serbia. The president of association is dr Liliana Goliani.
Members of SAAAM are doctors, dentists, pharmacists, biochemists, health workers, cosmeticians, nutritionists, fitness instructors, scientists and other experts interested in anti-aging in Serbia.
External links
Source: http://en.wikipedia.org/wiki/Serbian_Association_of_Anti-Agi...
Try to find answer in other search engines: Yandex, Google,


text:
RE: [XP] DTSTTCPW/YAGNI dilemma
Expand Messages
- Your original object C had n+1 jobs to do - handling n different protocols plus
deciding which one of them to use. You split the object into separate parts each
of which does something different. You proved it by coming up with a meaningful
name for each object. Your original object can't be named as easily. You can use
some meaningless abstraction, or you can call it LCP+CHAP+.....+Handler.
So I'd say it all comes under the heading of communicating intention.
Charlie Poole
> -----Original Message-----
> From: Ron Crocker [mailto:crocker@...]
> Sent: Wednesday, January 30, 2002 5:51 PM
> To: firstname.lastname@example.com
> Subject: [XP] DTSTTCPW/YAGNI dilemma
> Ok, I'm struggling with a problem here that I just can't convince my
> little mind to glom onto. Here's the problem, in a nutshell:
> Two parts of the system communicate through a third part, like this.
> +---+ +---+ +---+
> | A |<== protocol X ==>| C |<== protocol Y ==>| B |
> +---+ +---+ +---+
> This third part provides a set of services between these parts, so
> simply eliminating it is not an option. There's three kinds of services,
> two of which are truly between parts A and B, and another that's between
> A and C. The protocol used between A and C (X) carries the information
> that ultimately will be relayed to B (from C via protocol Y). A simple
> concrete example similar to my problem (that may be out of your area of
> expertise but is nonetheless accurate enough and simple) is that C is a
> router, protocol X is PPP, and protocol Y is IP. The messages between A
> and C include LCP (that terminates at the router) and those between A
> and B would be standard IP packets, carried from A to C as PPP frames,
> and then relayed by C to B as IP packets (in some other link layer
> protocol).
> Continuing with the PPP example, PPP frames contain a "protocol
> identifier" field that tell the router if the packet contained within is
> a LCP packet or a UDP or TCP packet. LCP packets terminate at C, while
> UDP and TCP packets are sent onward (ostensibly to B). I could envision
> code to handle this as follows:
> ...
> if (PID_LCP == pkt->protocolID) {
> // route packet to LCP handler
> } else {
> // route packet to IP forwarder
> }
> ...
> Ok, so let me further complicate the matter. TCP packets in PPP can have
> header compression applied to them (it's a fairly normal thing, really.
> goes by the moniker Van Jacobson Header Compression, aka VJ compression,
> as defined by, well, Van Jacobson, in RFC 1144). It turns out that C has
> to process these packets before it can simply forward them, so the code
> now becomes
> ...
> if (PID_LCP == pkt->protocolID) {
> // route packet to LCP handler
> } else {
> // route packet to IP forwarder
> if (PID_VJCOMP == pkt->protocolID) {
> // handle compressed header stuff before forwarding
> } else {
> // just ship it baby!
> }
> }
> ...
> Ok, so now let's authenticate PPP initiations via CHAP, which is also
> between A and C. More code changes, but its still pretty simple...
> ...
> if (PID_LCP == pkt->protocolID) {
> // route packet to LCP handler
> } else if (PID_CHAP == pkt->protocolID) {
> // authenticate this alleged subscriber
> } else {
> // route packet to IP forwarder
> if (PID_VJCOMP == pkt->protocolID) {
> // handle compressed header stuff before forwarding
> } else {
> // just ship it baby!
> }
> }
> ...
> So far, I think I'm still in the "DTSTTCPW" arena, but the code is
> starting to smell "icky." I can see where this is going, that I'm going
> to have a whole bunch of if statements to deal with the A<->C cases and
> then one last one to deal with all the A<->C<->B cases. I'd much rather
> look at this as:
> (code in packet receiver/dispatcher loop)
> ...
> // Let a handler deal with this packet
> PacketHandler.factory(pkt->protocolID).handlePacket(pkt);
> ...
> (code near packet handlers)
> ...
> public abstract class PacketHandler {
> public abstract void handlePacket(Packet _pkt);
> public static PacketHandler factory(ProtocolID _pid) {
> switch (_pid) {
> case PID_CHAP:
> return new CHAPhandler();
> case PID_LCP:
> return new LCPhandler();
> case PID_VJCOMP:
> return new VJhandler();
> default:
> return new DefaultHandler();
> }
> }
> }
> ...
> So my dilemma is understanding a) should I make this "leap" to a
> friendlier structure, b) how do I know when to make this leap -- more
> specifically, what did I do when that caused me to want to go to this
> other place, and c) how can I argue that the final answer isn't really
> the "simplest thing that could possibly work" -- for me, I naturally
> went there, well not first maybe, but surely second, and it is the
> simplest thing for me. The other one isn't simple, its only ugly.
> Encapsulation, compartmentalization, a single handling mechanism, ...
> all of those things feel simple to me. What exactly makes the last one
> simpler???
> Help me resolve my dilemma.
> Thanks!
> Ron C.
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