text:
Doctor insights on:
Does Pink Eye Cause Pain In The Back Of The Eye
Does pink eye cause pain in the back of the eye?
Not usually: Pink eye pain is usually more surface irritation. There could be a sinus pain associated with pink eye or it could be something more serious that needs evaluating. ...Read moreSee 1 more doctor answer
Pink Eye (Conjunctivitis) (Definition)
"Pink eye" refers to a viral infection of the conjunctiva. These infections are especially contagious among children. Newborns can be infected by bacteria in the birth canal. This condition is called ophthalmia neonatorum, and it must be treated immediately to preserve eyesight. "Pink eye" refers to a viral infection of the conjunctiva. These infections are especially contagious among children. Newborns can be infected by bacteria in the birth canal. This condition is called ophthalmia neonatorum, and it must be treated immediately to preserve eyesight. ...Read more
What is my back pain from I have had a serious sinus infection for 3 weeks. Currently I am recovering from the sinus infection and pink eye. Since recovery my back has been in chronic pain. I know it is not from coughing or anything and it is not just in
Most : Most likely you have strained your back from being sick, but rarely infections may spread through your blood to your back and cause an infection in your back. I would recommend being checked out by your primary care doctor. ...Read more
What is a pink eye versus uveitis in the eye?
Totally different: Pink eye is the popular term for conjunctivitis which in adults is usually caused by a virus infecting the liniing of the eye similar to a cold infecting the lining of the throat. Most are self limited and need little care. Uveitis is a sterile inflammation of the inside of the eye causing pain, light sensitivity and a risk of internal eye damage. Treatment is with steroids; see an ophthalmolog ...Read moreSee 2 more doctor answers
What could I do to find out if its pink eye or a sty in the eye?
Different locations: Pink eye refers to an infection in the conjunctiva, the clear membrane over the white of your eye. A sty is an infection in one of the glands in the eyelid. ...Read more
Can you use neosporin around the eye; it has become raw from rubbing from pink eye?
Pink eye: Yes you can. Keep in mind..pink eye is a very very contagious viral infection. If your rubbing all the time, your spreading virus all over your hands..and then to everyone around you. You should avoid touching your eyes at all when this happens. ...Read moreSee 1 more doctor answer
How can I tell the difference between my daughter having pink eye, begin poked in the eye, or something irritating her eye......She's 11 months?
Exam: She needs an exam. Getting poked would typically only cause tearing, and then lead to possible redness. An infection would be red with possible discharge and tearing, irritation could be all of the above. ...Read moreSee 1 more doctor answer
What is wrong if the eye drops prescribed for pink eye make my child scream when we use them?
Burning: This eye drop may be causing a burning sensation upon instilling it on the eye. ...Read moreSee 1 more doctor answer
Is pink eye contagious as long as the eye is pink? Been on eye drops 24 hours but still pink
Pink Eye: Pink eye (conjunctivitis) is not contagious after you have used antibiotic eye drops for at least 24 hours. ...Read more
Currently on eye drops for pink eye. It went away but now I have redness just on the outside and inner corner. Still taking the eye drops?
See eye doctor: Sometimes once the virus clears, the immune system still fights and you may need to see an eye doctor to look for infiltrates that may require steroid drops to clear. ...Read moreSee 1 more doctor answer
Can a child have a pink eye infection even if the eye is not looking pink?
No: Redness and drainage characterize a "pink eye" infection. ...Read more
Conjunctivitis (Definition)
Conjunctivitis is an inflammation of the thin mucous membrane that lines the front surface of the eyeball and the inside of the eyelids. As the inflammation increases, it causes the tiny blood vessels in the conjunctiva to dilate, thus leading to a redness of the eye. Depending on the cause of the conjunctitis there can also be itching, irritation, and discharge ...Read more
Eye Health (Definition)
Eye health involves the function and vision of the eye and all ...Read more
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SAN FRANCISCO (MarketWatch) -- Asian shares trading in the United States Tuesday advanced, despite tepid gains among technology shares, as India's stocks and the financial sector blazed ahead.
The Bank of New York Asia American Depositary Receipt Index finished 0.43 points higher at 129.02, and the overall Composite Index gained 0.61 points to 133.52.
India's shares came alive and boasted some of the index's top gainers. Shares of Internet provider Sify SIFY, -2.15% jumped 52 cents, or 6.9%, to $8.02. Rediff.com REDF shares spiked 9.6% to $18.56. Icici Bank IBN, +1.42% shares jumped 77 cents, or 2.9%, to $27.
Other standouts included shares of Dr. Reddy's Laboratories RDY, +0.37% which gained 1% to $21.17 and computer-services company Wipro WIT, +0.20% which climbed 1.7% to $11.10.
In individual sectors, banking shares enjoyed solid gains. Shares of Mitsubishi UFJ Financial Group MTU, -1.86% rose 4% to $13.63. Shares of Korea's Kookmin Bank KB, -1.58% advanced 3% to $67.72. Shares of Woori Finance Holdings WF, +0.18% also of Korea, added 1.2% to $53.40. So far, those shares are up 111% for the year.
Taiwan's tech shares lost steam as investors consolidated gains picked up over the last week. Shares of Taiwan Semiconductor Manufacturing TSM, +0.15% ticked 9 cents higher to $9.94. Shares of United Microelectronics Corp. UMC, +0.52% inched 3 cents ahead to $3.33. Au Optronics AUO, +0.75% shares fell more than 4% for a second day, ending at $13.42.
Among the day's standout losers, shares of China Medical Technologies CMED, +1.05% dropped 4.4% to $31.75. LG Philips LPL, +0.16% shares lost 3.9% to $21.20.

subset: commoncrawl


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text: El Picudo/Image gallery < El Picudo 95,301pages on this wiki Add New Page Edit History Talk0 Share General Event history Image gallery The following is a collection of images featuring El Picudo. Image gallery Add a photo to this gallery Retrieved from "http://prowrestling.wikia.com/wiki/El_Picudo/Image_gallery?oldid=432373" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Image gallery Gallery


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At graduation, she gave me a poster, in the cartoon style of the day, that said, "Feet Don't Fail Me Now," and signed my yearbook, "I am sure that you will succeed in all that you do, and running will always be an extra pleasure." (She actually wrote that in French, which was another gift to me: the love of foreign language and cultures. The fact that my son's middle name is "Luc" is illustrative of how important that has been in my life as well.)
I never saw Mrs. Norton after graduation, as I left the state for college, my family moved to a different town, and I never came back. I did call her two years ago when in Maine, and we reminisced about the old days and caught up a bit on the ensuing years. I meant to visit her then, but didn't make it up to Bucksport.
When I googled "Anne Norton, Bucksport," one morning last week, the second result, after a notice of her death, was a race result listing for a 2004 Run for Hope 5K in Hermon, Maine. Mrs. Norton ran 44:23 at age 68. She ran for life.
As a high school coach myself for the past 7 years, I am learning that students come and go quickly. You pour yourselves into them, then they move on. You don't forget them — they continue to be important as they progress in their lives — but you have new kids to focus on as well. I know that Mrs. Norton impacted thousands of other lives, and that many other continued to be more a part of her life than I have been and can speak more eloquently about who she was and what she meant to the world. I can only say that I am very glad that she was a part of my life for a crucial four years at the end of the 1970s.
Jonathan Beverly is Running Times' editor-in-chief. He grew up in Verona Island, Maine.


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An elderly couple goes to Burger King, where they carefully split a burger and fries. A trucker takes pity on them and offers to buy the wife her own meal. "It's all right," says the husband. "We share everything." A few minutes later, the trucker notices that the wife hasn't taken a bite. "I really wouldn't mind buying your wife her own meal," he insists. "She'll eat," the husband assures him. "We share everything." Unconvinced, the trucker implores the wife, "Why aren't you eating?" The wife snaps, "Because I'm waiting for the teeth!"
Doctor: Have you taken my advice and slept with the window open? Patient: Yes. Doctor: So your asthma disappeared completely? Patient: No, but my watch, TV, iPod, and laptop have. 3A business executive visits his dear Chinese friend in the hospital. "Li kai yang qi guan," says the sick man feebly. The executive desperately wants to help him, but he doesn't speak Mandarin. "Li kai yang qi guan!" says the patient, as he draws his last breath. Later that year, the executive is in Shanghai on business when he finally learns the meaning of Li kai yang qi guan: "Get off my oxygen tube."
某商业主管去探访生病住院的中国朋友,"Li kai yang qi guan," 病人微弱地说,商业主管很想帮助他,但不知他说的什么意思。"Li kai yang qi guan," ,咽气之前,病人再次这么说。那年年末,该主管去上海出差,最后终于明白了"Li kai yang qi guan" 就是"离开氧气管"的意思。
Indians ask their new chief whether the winter will be cold or mild. Since the young chief never learned the ways of his ancestors, he tells them to collect firewood, then he goes off and calls the National Weather Service. "Will the winter be bad?" he asks. "Looks like it," is the answer. So the chief tells his people to gather more firewood. A week later, he calls again. "Are you positive the winter will be very cold?" "Absolutely." The chief tells his people to gather even more firewood, then calls the Weather Service again: "Are you sure?" "I'm telling you, it's going to be the coldest winter on record." "How do you know?" "Because the Indians are gathering firewood like crazy!"
A neighbor finds a young boy sitting on the stairs crying. "What's the matter, honey?" she asks him. "It's my father," the boy sobs. "He hit his finger with a hammer." "Then why are you crying?" "Because first I laughed!"
Wife: Honey, did you notice? I bought a new toilet brush. Husband: Yes, I did. But I still prefer the paper.
In surgery for a heart attack, a middle- aged woman has a vision of God by her bedside. "Will I die?" she asks.God says, "No. You have 30 more years to live." With 30 years to look forward to, she decides to make the best of it. So since she's in the hospital, she gets breast implants, liposuction, a tummy tuck, hair transplants, and collagen injections in her lips. She looks great! The day she's discharged, she exits the hospital with a swagger, crosses the street, and is immediately hit by an ambulance and killed. Up in heaven, she sees God. "You said I had 30 more years to live," she complains. "That's true," says God. "So what happened?" God shrugs. "I didn't recognize you."
2010-03-14 11:05 编辑:kuaileyingyu
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Topic closed. 17 replies. Last post 3 years ago by Blackapple.
My study of Pick3 theory is large,
but application creates the hit.
New York. lottery has four Root sum ready
Root sums 4-9-5-7
I know they will release two of these.
Digit 3 & 8 as a key digit here
could mean 32x,34,36x,87x,89x or 18x plays...fact
OPTIMAL SUMS..8 ,12,15, or 17 DUE
Root sums 4-5-9-7
I know they will release two of these
One of the hits will employ
two of these digits 4-5-7-9-0
Root Sums:
4 067 013 112 157 256 679 148 238 346 5 068 014 122 158 167 356 266 023 239 347 7 016 124 115 178 556 367 268 223 034 349 9 036 018 126 135 117 567 189 234 369
Call it trap building
Thanks for the post BA!
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great posting Blackapple would i be understanding correctly by assuming the 6 digit still need to come in first or second position before this post is done? Thanks
Digit 8 stole the thunder,the advantage,
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The Facebook COO on navigating a new book, a new life, and a falling-out with her followers. Read More »
In Fort Bragg, one obsessed diver is trying to save the kelp forests by hoovering up purple urchins—one at a time. Read More »
A one-man play at the Curran Theater sends the audience into an altered reality with tricks of sound. Read More »
Bottega Veneta celebrates its 50th anniversary with the reissue of the Lauren bag—first seen on the legendary model-cum-actress in American Gigolo. Read More »
Riding along with the armed scientists and Forest Service commandos who hunt down California's toxic pot grows. Read More »
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That's the number of acres set aside for open space in the Bay Area—the most comprehensive land-conservation effort in the United States. And more is on the way. Read More »
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Environmentalists, ranchers, hikers, tule elk, and red-legged frogs fight for a permanent place in Point Reyes National Seashore. Read More »


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|Re: [jira] Updated: (COCOON-2059) ajax/common.js makes use of deprecated dojo.animation.Timer
|Sat, 21 Jul 2007 02:34:36 GMT
On 20.07.2007 22:04, Antonio Gallardo wrote: > I did not explained myself pretty well. It is supposed that all the > fixes from a previous version are included in all future releases. > Hence, an issue fixed in 2.1.11 is assumed to be fixed in 2.2. or not? Ah, that's different :-) No, we don't set all future versions, only the first one it is fixed in - but per branch. Maybe we have 2.2 before 2.1.11. Is the issue supposed to be not fixed in 2.2 then? So setting both versions adds additional and useful information. I think we have always handled it the per-branch way. Joerg
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A phase II study of concurrent chemoradiotherapy combined with a weekly paclitaxel and 5-fluorouracil regimen to treat patients with advanced oesophageal carcinoma
DOI: 10.1186/s13014-017-0785-0
© The Author(s). 2017
Received: 12 July 2016
Accepted: 22 February 2017
Published: 7 March 2017
A phase II study was performed to investigate the safety and efficacy of weekly doses of combined paclitaxel and 5-fluorouracil (5-FU) with concurrent radiation therapy, followed by 2 cycles of consolidation chemotherapy to treat patients with advanced oesophageal carcinoma.
The eligibility criteria included local, advanced, newly diagnosed and postoperative local regional lymph node metastasis; an Eastern Cooperative Oncology Group (ECOG) score of ≤ 2; and adequate organ function. Patients received chemoradiotherapy consisting of radiotherapy (50.4 Gy/28 Fx or 61.2 Gy/34 Fx) and concurrent paclitaxel (50 mg/m2) and 5-FU (300 mg/m2) for 96 h on days 1, 8, 15, 22, and 29. The two-cycle consolidation chemotherapy protocol included paclitaxel (175 mg/m2) plus continuously infused 5-FU (1800 mg/m2) for 72 h administered on days 57 and 85, after concurrent chemoradiotherapy.
Between February 2012 and August 2013, 53 patients with oesophageal carcinoma were enrolled in the study. Among these patients, 33 (62.2%) were newly diagnosed and 20 (37.7%) had postoperative local regional lymph node metastasis. The median overall survival (OS) time was 17.9 months (95% CIs = 11.9-23.9), and the median progression-free survival (PFS) time was 12.4 months (95% CIs = 8.6-16.1). Approximately 84.9% (45/53) and 50.9% (27/53) of the patients completed ≥ 5 cycles and all 7 cycles of chemotherapy, respectively. Approximately 86.7% (46/53) of patients completed radiation therapy. The 1-, 2-, and 3-year OS rates were 66.0%, 37.7%, and 35.8%, respectively. The 1-, 2-, and 3-year local control rates were 76.9%, 66.4%, and 66.4%, respectively. Seventeen patients (32%) experienced grade 3 or higher toxicity. Grade 3 to 5 toxicity during chemoradiotherapy included neutropaenia (7.5%), thrombocytopaenia (1.8%), fatigue (7.5%), anaemia (1.8%), dermatitis radiation (1.8%), pneumonitis (5.6%), oesophagitis (9.4%) and vomiting (3.7%).
The combination of weekly doses of paclitaxel and 5-FU was well tolerated and produced comparable results among patients with locally advanced oesophageal cancer. A randomised phase III trial (NCT01591135) comparing paclitaxel plus 5-FU with cisplatin plus 5-FU is on-going at our hospital.
KeywordsOesophageal carcinoma Paclitaxel 5-Fluorouracil Chemoradiotherapy
Oesophageal cancer is the fifth most common type of cancer and fourth most common cause of cancer-related death in China. This cancer is highly malignant because of high rates of local recurrence and metastasis. Definitive concurrent chemoradiotherapy is the standard treatment for non-surgery patients with oesophageal cancer, and the use of cisplatin with 5-fluorouracil (PF) is the most common chemotherapy regimen [1]. However, 5-year survival rates are poor (26%) following definitive chemoradiation therapy [2]. Thus, more sensitive, less toxic chemotherapy regimens are urgently needed.
Paclitaxel is a promising agent with regard to oesophageal cancer, with response rates of approximately 32% via single-drug treatment in locally advanced and metastatic patients [3]. Paclitaxel is a mitotic inhibitor that blocks cells during the G2M-phase of the cell cycle (i.e., the most radiosensitive phase), with a sensitising enhancement ratio of 1.48 [4]. The combination of paclitaxel and cisplatin (TP) is the most commonly used regimen, and the response rates among advanced and metastatic patients with oesophageal cancer are approximately 46%–59% [5–7], with a median survival of 6.9 to 13 months [5, 6, 8]. Radiotherapy concurrent with a monthly schedule of TP resulted in 3-year overall survival (OS) and local failure rates of 41% and 27.6% but a relatively higher haematological toxicity, resulting in neutropaenia grades 3 and 4 in 30.3% and 31.6% of cases, respectively [9]. Increased toxicity with no improvement in OS compared with the PF regimen was associated with the TP regimen for advanced oesophageal cancer [10].
The investigation of a new paclitaxel-based regimen and administration route is important for improving survival and reducing side effects. Effective and well-tolerated chemotherapy can prolong OS and improve quality of life. A pilot study of concurrent paclitaxel and 5-FU plus radiotherapy was developed for patients with localised oesophageal cancer at the University of Texas MD Anderson Cancer Center [11]. In that study, the continuous infusion of 5-FU and paclitaxel combined with radiotherapy 5 times was well tolerated; toxicities included mild vomiting, nausea, oesophagitis, and abdominal pain. The combination of paclitaxel and 5-FU was tolerated and effective. Based on these data, we began a phase II feasibility study to evaluate the failure-free local control rate, OS, and toxicities in patients with advanced oesophageal cancer treated with weekly paclitaxel and 5-FU.
Patient selection
The eligibility criteria for the study were as follows: (1) age ≤ 75 years; (2) Eastern Cooperative Oncology Group (ECOG) score 0–2; (3) cytologically or histologically confirmed oesophageal cancer; and (4) locally advanced, newly diagnosed patients with T2-4NxM0-1a or TxNxM1b (supraclavicular lymph node metastases for middle and lower thoracic oesophageal cancer or mediastinal lymph node metastases for cervical oesophageal cancer without organ metastases according to the 6th edition of UICC) or postoperative patients with local regional lymph node metastasis who did not receive chemotherapy or radiotherapy. Lymph nodes found via imaging increased gradually over the follow-up period, and the diameters of these nodes were more than 1 cm. This sign was considered to indicate postoperative lymph node relapse. Not all patients required a PET scan.
Patients were required to meet the following laboratory criteria: adequate bone marrow function (neutrophil count > 2.0*109/L, white blood cell count > 4.0*109/L, and platelet count > 100*109/L), normal renal function, and normal liver function. Patients with tracheoesophageal fistula, organ metastasis, or complete obstruction were not eligible for this study. All patients underwent a complete examination and nutritional assessments. The disease evaluation included an upper endoscopy, chest and abdominal computed tomography (CT), ultrasonography, and barium oesophagram examination to eliminate distant organ metastasis.
Ethical Considerations
Written informed consent was obtained from all patients before pre-study assessments, and the Ethics Committee of the Cancer Hospital Affiliated to Fudan University approved the study protocol.
Treatment schedule
Radiation therapy was administered using 3-dimensional conformal radiation therapy (3DCRT) or intensity-modulated radiation therapy (IMRT). Planning was performed using a Megavoltage simulator with a photon energy of 6 MV. For previously untreated diagnosed patients and recurrent patients, the gross tumour volume (GTV) was defined as the volume of the primary tumour observed on the oesophageal barium exam, upper digestive endoscopy and CT. Metastatic lymph nodes were defined as lymph nodes ≥ 1 cm in the shortest axis and ≥ 5 mm in the tracheoesophageal groove. The clinical target volume (CTV) was defined by adding 3-cm margins of proximally and distally uninvolved oesophagus without including the lateral margins and lymph nodes. The planning target volume (PTV) was calculated by adding 1-cm margins around the CTV, but the margins were reduced when the PTV recovered the spinal cord. All patients were treated with a total dose of either 61.2 Gy in 34 fractions or 50.4 Gy in 28 fractions. The lower dose was used when patients had abdominal lymph nodes metastasis or tumour in excess of the limitations of normal organs such as the lungs, spiral cord, or intestines.
The plan optimisation was as follows: (1) 99% of the PTV was covered by 95% of the prescribed dose; (2) 95% of the PTV volume was covered by the prescribed dose; (3) the maximum dose did not exceed 110% of the prescribed dose in a continuous volume of < 1 cm3 in the PTV; and (4) the maximum dose of the PTV did not exceed 110% of the prescribed dose in a continuous volume of < 1 cm3. The normal tissue constraints of the critical organs were as follows: a maximum spiral cord point dose of ≤ 45 Gy; a percentage of total lung volume receiving ≥ 20 Gy (lung V20) of ≤ 30% and a mean lung of ≤ 16 Gy, mean heart dose of ≤ 30 Gy, and maximum intestine dose of ≤ 50 Gy.
Assessment of primary tumour response
The response of the primary tumour was determined 3 months after the last cycle of chemotherapy was completed. Patients were scheduled to have CT scans and barium oesophagrams. If no obvious disease progression or symptoms were present, then the disease was considered to be controlled. If the disease progressed, then patients were scheduled to have endoscopy/biopsy, needle biopsy, or endobroncheal ultrasonography (EBUS). However, some of the patients who showed disease progression could not be given a clear pathological diagnosis because of the location of the tumour; these patients were diagnosed via imaging.
Follow up
Over the first year after treatment completion, the patients returned to the outpatient clinic every 3 months for a history and clinical examination. During the second year after treatment, the follow-up assessments occurred every 6 months and then every year until year 5. When applicable, disease recurrence, late toxic effects, and death were documented. Adverse reactions to chemoradiotherapy were evaluated according to the National Cancer Institute Common Toxicity Criteria version 3.0 (NCI-CTC 3.0).
Statistical methods
The primary end point of this study was the failure-free local control rate. The secondary end points included assessments of safety and compliance, OS, and progression-free survival (PFS). Local failure was defined as the recurrence or persistence within the radiation therapy PTV. Recurrence outside the treatment volume was defined as distant. OS was calculated from the first day of chemoradiation therapy to the time of the last follow-up assessment or death. PFS was defined as the time from chemoradiotherapy day 1 to progression, death, or last follow-up assessment. We hypothesised that the addition of paclitaxel and 5-FU would increase the failure-free local control rate. A sample size of 53 was required to detect an increase in the local control rate from 48% to 65% with a power of 80% and a standard error of 0.05. The data were analysed according to the intention-to-treat model. Kaplan-Meier curves were fit to estimate the OS and failure-free local control rates. Median survival estimates were calculated. Statistical analyses were performed using SPSS 20.0.
Patient characteristics
Patient characteristics (N = 53)
No.of patients (%)
Age (years)
46 (87.8)
7 (13.2)
50 (94.3)
3 (5.7)
Tumor location of newly diagnosed
33 (62.2)
2 (3.8)
Upper thoracic
7 (13.2)
Middle thoracic
9 (17.0)
Lower thoracic
9 (17.0)
Synchronous multiple primary
6 (11.3)
ECOG a score
48 (90.6)
5 (9.4)
Stage (UICC b 6 th edition)
Newly diagnosed
33 (62.2)
9 (17.0)
17 (32.0)
7 (13.2)
Postoperative LNMc
20 (37.7)
Planned dose of radiation
61.2 Gy
41 (77.4)
50.4 Gy
12 (22.6)
Local control and OS rates
Patterns of failure
Any failure
Locoregional failure only
Distant failure only
Locoregional plus distant
Feasibility and toxicity
Of all patients, 41 had a planned radiation dose of 61.2 Gy, and 38 (92.6%) completed radiotherapy treatment. Of the 12 patients with a planned radiation dose of 50.4 Gy, 8 (66.6%) finished the complete radiotherapy regimen. A total of 46 patients (86.7%) completed treatment based on our definition for completing the radiotherapy regimen. Seven (13.2%) patients did not finish radiotherapy because of grade II toxicity to the skin (1 patient), grade III cough and haemoptysis (1), fever lasting 10 days (1), grade III vomiting (1), obstruction of the oesophagus (2), or death from gastrointestinal bleeding (1). A ≥ 5-cycle dose of concurrent chemotherapy combined with paclitaxel and 5-FU during radiotherapy was administered to 45 patients (84.9%), and a full dose of 7 cycles of chemotherapy was administered to 27 patients (50.9%). Eight patients (15.1%) did not finish the 5-cycle dose of concurrent chemotherapy because of obstruction of the oesophagus (2), disease progression (1), adverse reactions (4), or death from gastrointestinal bleeding (1). The gastrointestinal bleeding was considered to be caused by a tumour.
Treatment toxicitya
No. (%)
No. (%)
No. (%)
No. (%)
No. (%)
21 (39.6)
8 (15.0)
3 (5.6)
1 (1.8)
9 (16.9)
4 (7.5)
1 (1.8)
21 (39.6)
8 (15.0)
1 (1.8)
9 (16.9)
3 (5.6)
1 (1.8)
7 (13.2)
1 (1.8)
14 (26.4)
3 (5.6)
3 (5.6)
1 (1.8)
9 (16.9)
6 (11.3)
7 (13.2)
2 (3.7)
9 (16.9)
3 (5.6)
1 (1.8)
16 (30.1)
11 (20.7)
1 (1.8)
Dermatitis radiation
10 (18.8)
5 (9.4)
1 (1.8)
25 (47.1)
16 (30.1)
5 (9.4)
6 (11.3)
2 (3.7)
1 (1.8)
2 (3.7)
2 (3.7)
3 (5.6)
2 (3.7)
2 (3.7)
3 (5.6)
Peripheral sensory neuropathy
13 (24.5)
4 (7.5)
5 (9.4)
1 (1.8)
2 (3.7)
3 (5.6)
1 (1.8)
5 (9.4)
Ventricular arrhythmia
1 (1.8)
Creatinine increased
1 (1.8)
Pericardial effusion
2 (3.7)
In our phase II study, the regimen of concurrent weekly paclitaxel, 5-FU, and radiotherapy showed promise for treating advanced oesophageal cancer in terms of the local control rate, OS, and low rate of side effects. Seventeen patients (32%) experienced grade 3 or higher sever events in this study. The common adverse reactions were bone marrow suppression, oesophagitis, fatigue, and pneumonitis. The 1- and 3-year local control rates were 76.9% and 66.4%, respectively. The median OS time was 17.9 months. The 1- and 3-year OS rates were 66.0% and 35.8%, respectively, although 69.8% (37/53) of the patients in this study were stage IV and showed recurrence.
Based on the 3-year follow-up results of our study and compared with other studies of PF concurrent radiotherapy, the paclitaxel and 5-FU regimen might have produced less toxicity and increased local control. In the RTOG 8501 study [2], local disease failure was the greatest cause of treatment failure and comprised 54% of the PF combined regimen therapy group. The median survival duration was 14.1 months with a 5-year survival rate of 26% in the chemoradiotherapy treatment group. In addition, grades 3 and 4 adverse reactions occurred in 42% and 4% of the patients, respectively. In the RTOG9405 study [12], patients were treated with radiotherapy doses of 64.8 and 50.4 Gy with DDP plus 5-FU, and the median survival times were 13.0 and 18.1 months, respectively. The incidence of local failure was 56% in the high dose group and 52% in the standard dose group. The RTOG9405 study was composed of 7.7% T4 patients and 21.5% N1 patients, and the incidences of grade 3 to 5 acute toxicity in the high-dose/low-dose groups were 76% and 71%, respectively. In our study, however, all patients had non-resectable or recurrent oesophageal cancer, including 17/33 (51.5%) previously untreated patients diagnosed with stage IV disease. Ohtsu et al. reported the use of chemoradiotherapy for oesophageal cancer with T4, M1 lymph node involvement, or both. In this study, the pattern of first failure was 57.4% (31/54) locoregional and 38.8% (21/54) distant, and the treatment resulted in a median survival duration of 9 months with a 3-year survival rate of 23% [13]. In our study, the median OS was 17.9 months, and the 1- and 3-year failure-free local control rates were 76.9% and 66.4%, respectively, which represented an improvement compared with the results reported in the PF regimen study.
Paclitaxel and cisplatin (TP) regimens are the most commonly reported paclitaxel-based regimens. The grade ≥ 3 haematological toxicity rates of TP are 30.6-73.7% [5, 9, 14]. In our study, the grade ≥ 3 haematological toxicity rate was 11.3%, which was lower than the results reported in a TP-based group study. Adelstein et al. reported the use of TP in a phase II study [10]. The median survival was 15 months for patients with stage T3, N1 or M1 (nodal) oesophageal cancer, which was lower than that observed in our study. Neutropaenia (95%) and nausea (95%) were the most frequent grade III/IV toxicities, and 16 patients (40%) experienced neutropaenic fever, which must be addressed. This toxicity is significant and was higher than that in our study. Tu et al. reported a retrospective study of combined-modality therapy consisting of the TP regimen with a concurrent IMRT of 60 Gy [14]. The median OS was 18.0 months, and grade 3 haematological and radiodermatitis toxicities were observed in 11 (30.6%) and 8 (22.2%) patients, respectively. That study was composed of 66.7% stage II-III patients. By contrast, all patients in the present study had non-resectable or recurrent oesophageal cancer, and only 16/53 (30.1%) patients were stage II-III. Tang et al. reported a phase II study of concurrent chemoradiotherapy with a 3-week schedule of TP for oesophageal cancer [9]. The median OS was 28.5 months; however, neutropaenia grade 3-4 occurred in 61.9% of the patients, with relatively higher haematological toxicity. In the RTOG 0113 study, one group was treated with TP and a radiotherapy dose of 50.4 Gy, and grades 3 and 4 adverse reactions occurred in 43% and 40% of the patients, respectively [15]. However, another group was treated with paclitaxel and 5-FU and exhibited lower treatment-related mortality and less grade 4 toxicity than a group treated with TP. These results suggest that compared with the cisplatin and 5-FU regimen containing paclitaxel, the adverse reactions in our study associated with paclitaxel and 5-FU were relatively low. The TP regimen might have higher haematological toxicity, similar to the results of a previous phase II study of concurrent chemoradiotherapy with TP for patients with inoperable oesophageal cancer [9].
The Chemotherapy for Oesophageal Cancer Followed by Surgery Study (CROSS) showed that neoadjuvant chemoradiation combined with carboplatin and paclitaxel concurrent with radiation significantly prolonged OS compared with surgery alone. Neoadjuvant chemoradiotherapy combined with a paclitaxel and carboplatin regimen did not increase surgery-related mortality. Thus, preoperative chemotherapy combined with carboplatin and paclitaxel followed by surgery should be considered as a standard of care among patients with resectable oesophageal cancer. A randomised phase III trial (NCT02459457) with a larger sample size is currently examining the efficacy of paclitaxel plus 5-FU compared with paclitaxel plus carboplatin concurrent with radiotherapy among patients with local advanced oesophageal cancer at our hospital.
While undergoing chemoradiotherapy in our study, 8 patients experienced fever, and 3 of these patients experienced febrile neutropaenia. The rate of fever was higher than expected and higher than the rates reported in other studies [9, 16, 17]. We do not have a reasonable explanation for this discrepancy, and the patient with a fever caused by pneumonitis without additional symptoms was treated with a similar approach as the fever patients and was not evaluated via chest CT. The grade 5 radiation pneumonitis rate was 3.7% (2/53), which was higher than that in other studies [9, 17, 18]. The 2 patients with grade 5 radiation pneumonitis completed concurrent chemotherapy, and both died within 3 months of undergoing the radiotherapy regimen; one patient with T4 received 61.2 Gy of radiation therapy, and the another with M1 received 50.4 Gy of radiotherapy. The lung doses associated with the two deaths were within the normal constraints. The lung V20 and mean lung dose of the two deaths were 19.1% and 23.4%, 11.6 Gy and 15.2 Gy, respectively. We do not have a reasonable explanation for this finding, which might be attributable to the small number of patients or the late stage of cancer. We believe that the lung dose was only one of the factors that affected the occurrence of radiation pneumonia. One study reported that 7% of patients with late-stage cancer succumbed to treatment-related death after chemoradiotherapy [13]. Similar to other reports [19, 20], 84.9% (45/53) of the patients in our study completed a concurrent chemoradiotherapy regimen. However, 18 patients did not complete the consolidation chemotherapy because they were unwilling (5) or experienced disease progression (5) or an adverse reaction (8). The completion rate of the full dose of 7 cycles of chemotherapy was lower than previous reports [19, 20]. Compared with patients in the later stages, their tolerance was poor.
The limitations of our study are as follows. 1) The homogeneity of the patients in the group was low; patients in phases II-III and IV were included, and postoperative recurrence was present. 2) The radiation dose was not uniform. Although the standard radiotherapy dose is 50.4 Gy in Europe and the United States, the radiotherapy dose for oesophageal cancer in China is often 60–70 Gy. Normal tissue could not tolerate the use of 50.4 Gy in our study. Wang et al. reported that patients who received a radiation dose of ≥ 50 Gy showed a better outcome than those who received < 50 Gy [20]. Regarding the limitations of our study, a randomised phase III trial (NCT01591135) with a larger sample size is currently examining the efficacy of paclitaxel plus 5-FU compared with cisplatin plus 5-FU with concurrent radiotherapy employing a unified dose of 61.2 Gy at our hospital. In that study, the patient inclusion criterion was local advanced oesophageal squamous cell carcinoma (T2N0M0-TxNxM1a, AJCC 2002). Any patients with exploratory thoractomy, radiotherapy, chemotherapy or targeting therapy were excluded.
In conclusion, our study indicates that weekly infused paclitaxel and continuously infused 5-FU for 72 h, followed by 2-cycle consolidation chemotherapy, is a promising regimen with good tolerability for patients with oesophageal cancer. Our study is limited by the small sample size. A current analysis of the efficacy of paclitaxel plus 5-FU compared to cisplatin plus 5-FU is ongoing at our hospital.
3-dimensional conformal radiation therapy
Computed tomography
Clinical target volume
Eastern cooperative oncology group
Gross tumour volume
Intensity-modulated radiation therapy
National cancer institute common toxicity criteria
Overall survival
Cisplatin with 5-fluorouracil
Progression-free survival
Planning target volume
Paclitaxel and cisplatin
Not applicable.
The National Natural Science Foundation of Chinese Research financially supported this study (Grants No. 21172043 and No. 21441010).
Availability of data and material
Our data were collected from patients treated at the Department of Radiation Oncology, Fudan University, Shanghai Cancer Center from February 2012 to August 2013. The inclusion criteria were as follows: (1) patient age ≤ 75 years; (2) ECOG score = 0-2; (3) cytologically or histologically confirmed oesophageal cancer; (4) newly diagnosed patients with local advanced cancer (T2-4NxM0-1a, or TxNxM1b; supraclavicular lymph node metastases for middle and lower thoracic oesophageal cancer or mediastinal lymph node metastases for cervical oesophageal cancer without organ metastases; 6th edition of UICC), or postoperative patients with local regional lymph node metastasis who did not receive chemotherapy or radiotherapy. The datasets analysed in the current study are available from the corresponding author (Kuaile Zhao) on request.
Authors' contributions
Kuai-le Zhao, Jian-hong Fan and Harun Badakhshi designed the study and performed the experiments; Yi Xia and Yun-hai Li performed the experiments, analysed the data, and wrote the manuscript; Yun Chen, Jun-hua Zhang, Qi Liu, Jia-ying Deng, Ta-shan Ai and Han-ting Zhu performed the experiments. All authors read and approved the final manuscript.
Competing interests
The authors declare that they have no competing interest.
Consent for publication
Not applicable.
Ethics approval and consent to participate
The Ethics Committee of the Cancer Hospital of Fudan University approved the study protocol.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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- Ohtsu A, Boku N, Muro K, Chin K, Muto M, Yoshida S, et al. Definitive chemoradiotherapy for T4 and/or M1 lymph node squamous cell carcinoma of the esophagus. J Clin Oncol. 1999;17:2915–21.View ArticlePubMedGoogle Scholar
- Tu L, Sun L, Xu Y, Wang Y, Zhou L, Liu Y, et al. Paclitaxel and cisplatin combined with intensity-modulated radiotherapy for upper esophageal carcinoma. Radiat Oncol. 2013;8:75.View ArticlePubMedPubMed CentralGoogle Scholar
- Ajani JA, Winter K, Komaki R, Kelsen DP, Minsky BD, Liao Z, et al. Phase II randomized trial of two nonoperative regimens of induction chemotherapy followed by chemoradiation in patients with localized carcinoma of the esophagus: RTOG 0113. J Clin Oncol. 2008;26:4551–6.View ArticlePubMedPubMed CentralGoogle Scholar
- Mariette C, Dahan L, Mornex F, Maillard E, Thomas PA, Meunier B, et al. Surgery alone versus chemoradiotherapy followed by surgery for stage I and II esophageal cancer: final analysis of randomized controlled phase III trial FFCD 9901. J Clin Oncol. 2014;32:2416–22.View ArticlePubMedGoogle Scholar
- Bedenne L, Michel P, Bouché O, Milan C, Mariette C, Conroy T, et al. Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol. 2007;25:1160–8.View ArticlePubMedGoogle Scholar
- El-Rayes BF, Shields A, Zalupski M, Heilbrun LK, Jain V, Terry D, et al. A phase II study of carboplatin and paclitaxel in esophageal cancer. Ann Oncol. 2004;15:960–5.View ArticlePubMedGoogle Scholar
- Chiu PW, Chan AC, Leung SF, Leong HT, Kwong KH, Li MK, et al. Multicenter prospective randomized trial comparing standard esophagectomy with chemoradiotherapy for treatment of squamous esophageal cancer: early results from the Chinese University Research Group for Esophageal Cancer (CURE). J Gastrointest Surg. 2005;9:794–802.View ArticlePubMedGoogle Scholar
- Wang S, Liao Z, Chen Y, Chang JY, Jeter M, Guerrero T, et al. Esophageal cancer located at the neck and upper thorax treated with concurrent chemoradiation: a single-institution experience. J Thorac Oncol. 2006;1:252–9.View ArticlePubMedGoogle Scholar


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Doctor insights on:
Lung Cancer Xrays
Can lung cancer ever appear on an xray, be diagnosed as pneumonia and then not appear on two subsequent xrays or was it really pneumonia.
Why do you ask?: i am glad it is gone. I would trust the imaging specialist especially if there are two films without cancer after the pneumonia is gone. ...Read more
Cancer (Definition)
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
I just had an angio pulmonary cat scan with contrast to rule out a pulmonary embolism. Can that detect lung cancer? Chest xray normal. 42 years old.
Depends on size: Many patients who undergo a ct scan of the chest will have small or medium size nodules that are non-specific. A radiologist will document the size, and depending on the patients age and risk factors for developing lung cancer will recommend appropriate followup studies or sometimes even recommend a biopsy. We can suspect, but not diagnose lung cancer without a tissue diagnosis. ...Read moreSee 2 more doctor answers
What does lung cancer in an xray look like?
White round circle: Lung cancer tumors look like white round circles on cxr. ...Read moreSee 1 more doctor answer
Can shortness of breath be the only symptom of lung cancer...had clear chest xray and 2 negative d dimers (all 3 in December)...scared!
More info needed: Shortness of breath can have many causes, including heart disease,lung disease, clot in the lung, and anemia. it does not necessarily indicate lung cancer. Your doctor can help sort this out. ...Read more
Liklihood of a 25 yr old having lung cancer after clear chest xray, lungs sound clear, coughed up decent streak of blood, clearing throat alot?
Near about Zero!: Lung Cancer is extremely rare before the age of 40. If you lung symptoms persist or get worse go see a pulmonologist to check you thoroughly. ...Read moreSee 2 more doctor answers
What does lung cancer look like on an xray?
May vary: It may look like a small round nodule with smooth or spiculated edges. In some instances, it may have the appearance of ground glass or pneumonia. The clinical situation must be evaluated by your doctor. ...Read moreSee 1 more doctor answer
What does lung cancer look like on an x-ray?
It varies: It can be a mass, or unusual calcifications, or an unusual "infiltrate" on a chest x-ray. In other words, it can have many different appearances. A chest x-ray is a great tool, but it takes skill to interpret. I do not recommend you try to interpret your films, but your doc can review it with you to give insights. Hope this helps. ...Read moreSee 1 more doctor answer
Small cell lung cancer. How long was it there when you can see it on x-ray?
Weeks to months: There is no hard and fast rule. In studies that tried to detect lung cancer early using a chest x-ray, almost half of the cancers appeared within a year of a normal x-ray. Taking into account the rate of growth of a cancer cell, and the minimum size needed for detection on x-ray, a good estimate for small cell is a few weeks to a few months. ...Read moreSee 2 more doctor answers
Could lung cancer (of any type) not show up on an X-ray after 14 months of symptoms?
(Theoritical question not for diag.)
Yes: Especially, adenocarcinomas in the apex can be very small and hide behind other structures. ...Read more
What does lung cancer " mass" look like on an xray?
Density: The tumor is dense so it blocks x-rays and shows up as a white circular mass on x-ray. ...Read moreSee 1 more doctor answer
Lung (Definition)
Deoxygenated blood enters the lungs from the right side of the heart and travels to the lungs. When you inspire, oxygen flows into the lungs, transverses the capilliares and attaches to hemoglobin down a gradient. At the same time, co2 diffuses into the capilaries and is expelled with exhalation. Oxygen rich blood then flows to the left side of the heart and into the ...Read more
Lung Cancer (Definition)
From national cancer institute: "cancer that forms in tissues of the lung, usually in the cells lining air passages. The two main types are small cell lung cancer and non-small cell lung cancer. These types are diagnosed based on how the cells ...Read more
- Talk to a doctor live online for free
- Will chest xray show lung cancer
- Can a xray show lung cancer?
- Can a xray miss lung cancer?
- Ask a doctor a question free online
- What does an xray look like for lung cancer?
- Lung xray shows pleural thickening is that precursor to cancer
- What does lung cancer look like on chest xrays?
- What does lung cancer look like on a chest xray?
- Talk to a oncologist online for free


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Definition from Wiktionary, the free dictionary
Proper noun[edit]
- (paganism) The goddess of the night in Heathenry.
- (pagan goddess) "In this prayer, Sigdrifa calls upon powers of Nature - Day, Night, Earth - and the gods and goddesses as a group." Our Troth, Ring of Troth and other True Folk, Ring of Troth, ISBN 0-962357-8-1, 1993, page 383.
- (pagan goddess) "Hail to Night and her daughters. Teutonic Religion, Kveldulf Gundarsson, Llewellyn Publications, 1993, ISBN 0-87542-260-8, page 316.
- (pagan goddess) "In another story, the Allfather, the original sky god from early Wyrd culture, took Night and her son Day, and gave to each of them a horse and chariot and put them in the sky, so that they should ride around the world every twenty-four hours. The Wisdom of the Wyrd, Brian Bates, Rider, 1996, ISBN 0-7126-7277-X, page 48.


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Heimtextil 2017
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Zebra Textile Company, SL was created in 1994. It is a young company with great prospects located in the industrial area of Ontinyent, a major textile hubs in Europe.
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Our designer lines include woven fabrics for decorating: curtains, upholstery and made products, having a stock of all references.
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From Our Editors
A variety of healthy pet food, toys, and bedding stock New Age Pet Supply's wide aisles—just wide enough, in fact, for a pup to follow behind as his owner sniffs around the shelves. The independent pet store's staff dispenses advice on animal ownership and helps visitors select the right gear for their pets, from cat strollers and dog bowties to bird feeders and heating pads for reptiles. New Age also keep critters healthy with grooming services, vaccinations, and teeth-cleaning that doesn't use anesthesia and forges the bonds between man and beast with its own adoption program and an in-house photography studio.


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MOLECULES ARCHITECTURE www.molecules-project.eu ETRA - M.José Durà 27th – 28th March
Objectives Open Architecture for smart connected electro-mobility Objectives: To define a reference architecture and principles common for the three pilot sites, considering the requirements and use cases specified in the project. Identify a common Information Model. Specify ICT Services granting integration of the electro-mobility modes of transport with the rest of public transport systems. 2
Objectives Open architecture Specifications are public Easy add-on products: Allow third-parties to evolve the application Common terminology Interoperability Availability of data: Standard (open) interfaces 3
Approach Bottom-up approach Piecing together of systems to give rise to grander systems, thus making the original systems sub-systems of the emergent system. 4 Individual base elements already developed Scenarios: Use cases Link together these elements to form larger subsystems
Approach Starting from the use cases in each pilot site. 5 General Open electromobility Architecture Molecules Open Architecture Molecules Barcelona Architecrure Molecules Grand Paris Architecrure Other CIP projects Molecules Berlin Architecrure
Work flow 6 Business analysis RequirementsDesign Implementation and integration TestingDeployment
Work flow 7 UML diagram types Static model Dynamic model Components diagram Deployment diagram Use cases diagram Sequence diagram
Principles The architecture is a high level structure of the system, specifying the diferent commponents, its properties and the external relationships between them. BASIC PRINCIPLES TO CONSIDER: Hide complexity. Separate concerns. Design using interfaces. Separate / distribute responsibilities. 8
Thanks for your attention. Any questions? 9 email@example.com firstname.lastname@example.com
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Student Alumni Relations Cell
The Student Alumni Relations Cell works towards achieving a meaningful relationship between the Alumni and the institution. The students being the most important part of the institute graduate into alumni and become the most important long term stakeholders of their Alma matter. The club provides an opportunity for the alumni to interact with the faculty and the students and helps build a relationship which lasts for many years. It helps the Alumni to stay updated on different activities conducted by the college.
Few Prominent Activities:
- Grand Alumni Meet is conducted every year at Goa campus, the association also holds summer meets in few of the major cities of India like Delhi, Mumbai, Chennai, Bengaluru and Pune. These meets helps in bringing alumni together and serves as a platform for alumni to catch up with their batch mates and professors.
- "Summer Solstice", an event aimed to encourage students to excel in their Summer Internships. The event is judged by the prominent Alumni from the institute and a gold medal is rewarded to the student for best summer internship project.
- "Hangout" - A recent initiative by the Alumni Association focuses on making students of the institute industry ready. Alumni are invited to share their industry
Contact Us
Student Committee
|Aditi Khandal
|Arpit Madan
|Jubin Mathews
|Shashank Krishnan
|Sherry Mathew
|Soumya Jain
Standing (L to R): Arpit Madan,Shashank Krishnan,Sherry Mathew
Seating (L to R): Soumya Jain,Jubin Mathews,Aditi Khandal


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Marc Anthony Comes Close, but is no Lavoe
Not even the shorest glimpse of the movie El Cantante is not necessary to understand Marc Anthony is no Hector Lavoe.
Short on schooling but long on raw ability and bravado, Lavoe had a unique propensity – unlike Anthony whose antics at times seem forced – to grasp a stage with his austere voice and gloomy, elongated improvisations.
Whether or not Anthony hits the target of depicting the famed Puerto Rican/Fania All-Stars vocalist in the biographical movie being released next month remains to be seen – although early reviews haven't been very glowing.
But Anthony does a credible job of interpreting "Mi Gente" (My People), the just released single of the movie soundtrack and one of Lavoe's biggest hits over 30 years ago.
Upcoming Events
South Florida JAZZ presents: Christian McBride Trio
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TicketsWed., Jul. 26, 7:30pm
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TicketsMon., Aug. 28, 7:00pm
Despite experiencing an obvious strain in trying to hit the downtrodden tone of the opening verses of the song, Anthony makes up for it by soaring above the rumbling of trumpet and timbales with audacious calm and authority.
Unlike in some of his original material, Anthony does the smart thing and backs away as the intermix of instruments – including a Willie Colon trumpet solo - carries the latter half of the song and lends it the very vibe that made the song a classic years ago.
Anthony's improvisational skills are sharp as he pays homage to Johnny Pacheco – the song's author – with a call out asking him if he knows where his grandmother is before answering his own question. His voice hops from the lyrical improvisation to a high-energy pitch drawing out of notes, a staple in most of his songs.
The only downside is that the remake is significantly shorter than the original, which obviously didn't allow such a masterpiece the justice it truly deserves. -- Fernando Ruano Jr.
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Jammu, Nov 6 (UNI) Terming the developments in Pakistan as a cause of concern, Peoples Democratic Party (PDP) patron Mufti Mohammad Sayeed today said New Delhi can send a positive message across the border by strengthening the ''forces of peace'' in the sub-continent.
The former chief minister, while addressing a public rally at bordering R S Pura sector, said without diluting its agreed national policy of not interfering in the internal affairs of the neighboring countries, India could seize the situation by taking ''certain politically courageous steps'' towards the peaceful and ultimate settlement of the Kashmir issue.
''Facilitating the political forces to take full control of the state's affairs by strengthening and consolidating the democratic and the civil society institutions would have a visible impact on the fast-changing situation in the state,'' he said.
Such steps, Mr Sayeed said, would also provide a space to the forces of peace across the borders, who have been piloting peaceful and amicable settlement of the Kashmir issue.
He said the emerging situation in Pakistan, instead of decelerating the peace efforts, might provide an opportunity to New Delhi to accelerate, both reconciliation and resolution process within the state in the larger interest of the region's peace and stability.
The PDP patron said such measures should also send a signal to those who had taken up the gun in their belief to resolve a political problem through it.
''They must be made to realise that the gun has lost its impact and ability to achieve political objectives and dialogue is the only recourse,'' he said, adding that all this needs a political will and the trust in the people of Jammu and Kashmir to consolidate the peace process.
He said the successful ceasefire along the borders and the Line of Control (LoC) holding for the past couple of years has heightened the hopes of peace among the people and the two countries should extend this bonhomie to the plains as well.
''With Afghanistan already on the boil, destabilisation and worsening of the security situation in Pakistan would only breed new alarming dangers in the region,'' he said and added that a discreet approach to the situation by New Delhi would not only signal India's positive support for Pakistan's territorial integrity but would also send to the people of neighboring country a message of goodwill.


text: Category : Sewing and Knitting The Domesticated Engineer Releases Oven Fresh Collection Sewing and Knitting Mark 0 Apr 06, 2017 Andrea Kjorlaug, the owner and designer of The Domesticated Engineer, is a structural engineer by day whose creative side has caused her to become sought after for wedding and home decor. Her Oven Fresh Collection is highly anticipated as it… 1 san2016 Twice Sheared Sheep Announces Their New Spring / Summer Recycled Yarn Line "The Cotton Collection" Sewing and Knitting Mark 0 Apr 04, 2017 Twice Sheared Sheep invites yarnies everywhere to 'welcome back the sun" with their new cotton recycled yarn line. Just in time for warmer weather, the respected yarn recycling company has announced the release of their first ever cotton yarn collection.… 1 san2016 Storybook Blankie Utilizes Equipment Financing to Launch Unique Embroidery Business Sewing and Knitting Mark 0 Nov 30, 2016 In March 2016, Beacon Funding helped Sydney Allen finance a 15-needle, single-head embroidery machine allowing her to establish Storybook Blankie, a home-business producing highly customizable baby blankets. Allen planned to change the way stories are told to children by embroidering… 1 Denise Fitzgerald Purposeful Indulgence Announces Exciting Launch of "Brilliant Memories", a Handmade Collection Featuring Kitchen & Dining Essentials that can be Creatively Personalized with Markers Sewing and Knitting Mark 0 Nov 03, 2016 Personalized gifts are often the most thoughtful, memorable, and unique – especially ones that allow the whole family to participate. 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Inspired by those crystal clear winter skies and the feathered friends… 1 Denise Fitzgerald Brie & Vessie is Set to Take Center Stage With Their Huggable Harvest Collection Sewing and Knitting Mark 0 Oct 10, 2016 Brie & Vessie is proud to announce the Huggable Harvest Collection, set to premiere October 18, 2016. This 10-piece collection features cozy and warm clothing that will keep your little one cute, and comfy this coming season. Designer Kathy Terry meticulously… 1 Denise Fitzgerald Herdoso Holiday Collection Makes Gift Giving Easy Sewing and Knitting Mark 0 Oct 10, 2016 Herdoso, a handmade business located in Minneapolis, Minnesota, is pleased to announce the Herdoso Holiday Collection, a selection of ten linen tissue box covers ideal for gift giving. Whether you're looking for that perfect gift for a friend or loved… 1 Denise Fitzgerald Twice Sheared Sheep Announces Their First Ever Hand Dyed Recycled Yarn Line Titled "Hidden Forest" Sewing and Knitting Mark 0 Oct 10, 2016 Twice Sheared Sheep is set to release stunning new line of hand dyed recycled yarns to the delight of their eagerly awaiting fans. The respected yarn recycling company invites knitters to experience the beauty of an enchanted forest this fall… 1 Blakelee Midyett Wilcom Launches Hatch Embroidery Software for the Home Market and Announces Partnership With Adorable Ideas Sewing and Knitting Mark 0 Sep 19, 2016 Wilcom today announces their new flagship product for the home embroidery market – Hatch Embroidery Software. It is the first home embroidery software solution sold exclusively online and designed by a team of professionals who have been at the forefront… 1 Alicia Perry Miaba Introduces New Constant Comfort and Garden Collections to Lavish Your Little Ones With Luxury Sewing and Knitting Mark 0 Aug 23, 2016 Celebrate the little loves in your life with gorgeous heirloom quality gifts worthy of any expectant mother's adoration and which any child will cherish. Miaba, a brand known for lovely knit and crochet blankets which please babies, toddlers, and parents… 1 Amena Hunt Sewn Lakeside Announces Launch of the Small Fry Collection, Kid's Bags That Are Ready for Adventure Sewing and Knitting Mark 0 Jul 19, 2016 Sewn Lakeside is proud to announce the release of its latest ten piece line, fittingly named The Small Fry Collection, designed and made with kid's needs in mind. The collection includes the kid sized, fun yet functional Small Fry Messenger… 1 Amena Hunt 'Tis the Season to Create New Holiday Memories and Traditions With the Sugar House Shop Sewing and Knitting Mark 0 Jul 18, 2016 The holiday season is a time to honor family traditions, create new memories, and share the joy of the birth of Jesus Christ with friends and family. What better way to start building the anticipation for this glorious season than… 1 Amena Hunt Kari's Kits Debuts Hand Knit Fall 2016 Line With Cabled Kitten Collection Sewing and Knitting Mark 0 Jun 27, 2016 Kari's Kits developed the new product line in response to customer demand for playful knit pieces that are finely made, sumptuous to touch, and most importantly – already made. The collection features hand-knit sweaters, hats, and headbands, as well as… 1 Kari Capone Studio TKB Presents Sewing Patterns 'For Grown Ass Women' Sewing and Knitting Mark 0 Jun 21, 2016 Tina Kim, Sewist and Owner of Studio TKB is launching the inaugural Galaxy Whisper Collection of Yoga & Activewear sewing patterns 1 JULY 2016 | ST. SIMONS ISLAND, GEORGIA Created for women of all ages and sizes, Studio TKB's Galaxy… 1 Kari Capone Sweet Peony Studio Is Primed to Sell Out of Their Newest Pregnancy Reveal Collection. Sewing and Knitting Mark 0 Jun 21, 2016 The new collection, launching July 1st 2016, captures the trendiness of your own adult footwear fashion but in a baby shoe. Styles including a slouchy boot, boat shoe and petite peep toe pump are just a few of the adorable… 1 Amy Kunz Twice Sheared Sheep Announces New Luxury Recycled Yarn Line Dubbed "Color Play" Sewing and Knitting Mark 0 Jun 06, 2016 The respected yarn recycling company, Twice Sheared Sheep, invites knitters to effortlessly play with color in their new yarn line entitled "Color Play." The line includes professionally coordinated hues to take the guess work out of color selection and lay the… 1 Kelly-Anne Shoaf Adwoa Design Launches the 80's Royalty Amigurumi Doll Collection Sewing and Knitting Mark 0 Jun 02, 2016 Adwoa Design's new Amigurumi Doll Collection will consist of dolls resembling popular celebs. To include: Whitney Houston, Michael Jackson, Prince, Bob Ross, The Golden Girls, Madonna, David Bowie, Cyndi Lauper, Billy Idol, Boy George and LL Cool J, and others.… 1 Adwoa Grier Renae Christine Presents Her New Handmade Titan Planner Collection: The Ultimate Planner for Your Handmade Business Sewing and Knitting Mark 0 May 24, 2016 Intricate product planning and time management are now a piece of cake for handmade entrepreneurs more so, work at home moms. Leading online entrepreneur Renae Christine has launched her own new product line collection specifically meant for handmade entrepreneurs. The… 1 Jamie Anderson This Spring Is All About Baby! Sewing and Knitting Mark 0 Apr 18, 2016 Celebrate the arrival of a new little one with simply luxurious heirloom quality gifts that any expecting mother would adore receiving at her baby shower. Spring is here and with its arrival the Earth begins to blossom in all its… 1 Adwoa Grier Load more Posts


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Sets up easy and heats up to 500 square feet.
Mr. Heater Vent-Free Radiant Propane Heater, 18,000 BTU
Item # WX2-651031
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- Don't suffer the cold any longer. With a Mr. Heater® 18,000 BTU Vent-free Radiant Heater, warm comfort is a simple button-push away. It fills a room up to 500 square feet with radiant heat and can be mounted to the wall, fastened to the floor or stand on its feet to remain portable. And with the safety features that come standard on Mr. Heater® products, rest assured you'll have a safe heat source to last for years!
- Heats up to 500 sq. ft.
- Radiant heat burner
- Automatic low-oxygen shutoff system (oxygen-depletion sensor)
- High-limit safety shutoff
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- Piezo ignition
- Includes legs and wall-mounting hardware
- Safe for indoor use
Note: Heater does not come with blower. Integrated blower sold separately. Turn up the heat and order today!
Please Note: Once items have contained gas, kerosene, butane, lighter fluid, diesel, or oil they cannot be returned to The Sportsman's Guide.Key Specifications
- Item Number: 651031
- BTU Rating: 18,000
- Burn Rate: .926 lb./hr.
- Variable Output: No
- Heating Area: 500 sq. ft.
- Fuel: Propane
- Min. Tank Size: 20lb.
- Certified: Yes
- Low Oxygen Shut-off Switch: Yes
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- Wall Mount Hardware Included: Yes
- Ignition: Electronic
- Integrated Blower Fan: Sold separately (item #651020)
- Thermostat: Yes
- Measures 19" x 8" x 24TMh. without removal legs
- Weighs 33 lbs.
- MFG Number: F299820
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6 Do's and Do-Not's for Naturally Beautiful Skin
9th August, 2016 - Posted by Victoria Girard
The key to healthy skin lies beyond the products you use. It depends on what you eat, your physical activity, stress you're under and the environment in which you work and live. All these factors decide how fast your skin ages. Apart from these determinants, there are some skin care dos and don'ts you need […] Read More


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Inkjet refills for Epson T0734 (73 Yellow) cartridge at discounted price! Whether you want to refill your empty Epson T0734 (73 Yellow) ink cartridge using our refill kit or just looking for ready-to-use cartridge replacement, - we can satisfy everyone!
We offer the following compatible inkjet refills for Epson T0734 (73 Yellow) ink cartridge:
Inkjet Refill Kit
Compatible/Remanufactured ink cartridges
Original OEM ink cartridges
Remanufactured Epson T0731 Black ink cartridge
Remanufactured Epson T0732 Cyan ink cartridge
Remanufactured Epson T0733 Magenta ink cartridge
Remanufactured Epson T0734 Yellow ink cartridge
PLEASE NOTE: Unfortunately we don't have the refill instructions for Epson T0734 (73 Yellow).
The following bulk printer ink is compatible with all cartridges, but we unable to assist you with refilling Epson T0734 (73 Yellow) cartridges.
We recommend ready-to-use cartridges above.
Yellow - DuraFIRM Bulk printer ink - 60ml - 2oz
Injector Kit for Inkjet Cartridge Refills
Inkjet Cartridge and Printhead Cleaner - 60ml - 2oz
Postcard Size Satin Photo Paper (4 x 6 inches, 50 sheets / pack)
Glossy 9mil Photo Printer Paper (40pcs / pack)


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Have you noticed a foul odor in your yard? Does that odor seem to get worse when water is running your house? Are your toilets and sinks backing up, and does that backup smell horrible and look like it contains sewage? If answered 'yes' to any of these questions, there's a good chance that you need to have your cesspool replaced.
Replacing a cesspool is a big job, but with the right knowledge and the right company, the task can be a lot less stressful for you. Here's a look at some important things that you should know before you have your cesspool replaced.
The Size and Cost of the Cesspool
The cost of the cesspool is directly related to its size, and the size of the cesspool that you need depends on the size of your home. Typically, an average three-or four-bedroom house will need a 1,000 gallon cesspool, which costs approximately $8,000 to $15,000. If your house has five bedrooms or more, you will likely need 1,500 gallon cesspool, which costs between $15,000 and $25,000.
In addition to the cost of the cesspool itself, you also need to factor in the cost of the work that is involved with installation. The cost of installation will depend on certain factors, including the complexity of the job. On average, it will cost between $3,000 and $7,000 to replace an existing cesspool.
Construction Considerations
Heavy machinery and large equipment is needed to pull out your old cesspool and install a new one. To prevent damage to your property, make sure that the tools and equipment that need to be used can easily access the area. For example, if you just had a new driveway or walkway installed, the machinery could cause damage.
You also want to make sure that no heavy traffic goes over the area where the new cesspool is installed, as it could compact the soil and impact the function of the cesspool. Make sure that cars or other heavy items will not be passing over the area after installation.
Permits, Inspections and Tests
Permits and inspections will be necessary before removing your old cesspool and installing a new one. Environmental testing may also need to be done. Contact your local health department to find out exactly what permits, inspections and tests are required.
The time it takes to attain permits and have inspections and testing done can impact the amount of time it takes to have a new cesspool installed.
Finding a Reliable Cesspool Professional
When choosing a an emergency cesspool pumping company, make sure that you choose a licensed expert. Also, if you want to make sure that you get bids from several companies to make sure that you get the best price. It's also wise to ask about warranties and guarantees the companies offer before making your final decision. Consider reviews from past customers and the experience the company has, too.
Installing a new cesspool for your home can be an overwhelming task, but this information can help to simplify the process and make it a more successful one.


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A typography piece that praises womenhood.
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