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Town Square
Freeway noise in Canyon Creek Cir
Original post made by Jenny, Canyon Creek, on Jul 15, 2012
Also, this house has been sitting in the market for a month now even though many other houses receive multiple offers. We are afraid that it will be difficult to sell.
Is Canyon Creek a desirable community? Can anyone tell us more about this community? Are there many small kids? What is the demographic diversity?
Thank you very much.
Comments (28)
a resident of another community
on Jul 15, 2012 at 10:41 am
Jenny, You are probably not wealthy enough to buy in Ruby Hills or the Preserves, and this on account of the miserable Obama administration, its unwillingness to give people better jobs, and its shameful attacks upon by record. But given all these unfortunate considerations, I'd buy the Canyon Creek house and regard the car and truck noises outside as the Sounds of Freedom.
Unfortunately, there are those who want public transportation projects to take precedence over privately owned autos and corporate owned trucks. But when you hear those cars and trucks humming along behind your new home at 3 AM, and you open your bedroom window for you and the kids to suck that great American exhaust into your lungs, just give thanks we don't live in a socialist society with its leveling public works projects.
a resident of Ruby Hill
on Jul 15, 2012 at 3:02 pm
Ruby Hill was built before Obama was in office. Good luck, Jenny, people can be rude sometimes. You might want to reconsider and buy a house in Livermore.
a resident of Oak Hill
on Jul 15, 2012 at 10:51 pm
Yes, a house that close to the freeway will be more difficult to sell when you move someday in the future, so the current listing price of the house should reflect that. Also, in addition to the noise you should consider air pollution issues associated with houses that close to the freeway. The neighborhood is a small, rather isolated group of about 30 houses on the western edge of Pleasanton, so I think you really need to knock on the doors of some of the houses there and talk to your prospective neighbors to get a better idea of what life in that neighborhood is like.
a resident of Valencia
on Jul 16, 2012 at 8:18 am
I see listings for that area periodically...and the price is usually attractive but not worth it! You will be contending with the noise as you try and relax and BBQ in your yard, when it is a beautiful day out and you rather have the windows open vs. air conditioning, etc. Not only the noise, but I commute past there on the canyon road and it looks challenging trying to exit out of that complex - I see cars waiting trying to take a left which is where you will be wanting to go the majority of the time. Somewhat of a blind curve there. Don't do it!
a resident of Another Pleasanton neighborhood
on Jul 16, 2012 at 8:38 am
What is the deal with the PW selecint postings for the main page from people wanting to know if the noise or smell is excessive in a neighborhood? Has this site degraded to the point that they have to select this stuff for the main page?
a resident of Castlewood Heights
on Jul 16, 2012 at 8:58 am
Maggie, now after you have wrecked one small community by giving your primitive opinion. Check out your own community. And don't forget the Freeway #580. You may not hear it due to the wind generated noise by the Dublin wind corridor.
a resident of Another Pleasanton neighborhood
on Jul 16, 2012 at 9:48 am
Do posters who complain about pollution from the freeways not own a car/vehicle - you get pollution from the car sitting in your garage/driveway - cars are everywhere - so it doesn't necessarily have to be any different whether you live near a freeway or not - your neighbour might have a gas guzzler/turbo charged/suped up car etc and then you complain about freeway pollution - get over it! But I suppose your responses are that you ride a bicycle everywhere so you don't add to the pollution but somehow I doubt it.
a resident of another community
on Jul 16, 2012 at 9:53 am
If you have traffic noise a great way to disguise it is to purchase a water fountain - we back onto the 680 and prior to owning the water fountain you could hear the traffic clearly but the noise of the water deafens the traffic sounds - just a thought! If this is the house you can see becoming your home I say go for it, Pleasanton is a lovely place to live.
a resident of Ponderosa
on Jul 16, 2012 at 11:40 am
Jenny, Don't listen to most of these people. None of them live there and have only their own fears to offer. And pay not attention to the mentally disturbed 'Mittens'. If it rains its Obama's fault. If it doesn't rain its Obama's fault. It's pretty much a one trick pony with that one.
Here is some information that may be more helpful. I live on the other side of the freeway from where you are looking. I'm five houses from the freeway. Before making our decision we did talk with the people at the freeway side. They have a two-story home. They told us that the sound wall blocks out most of the noise and they hardly hear it. And as we stood outside talking, it was indeed less noisy than standing in my new front yard. We moved into the house in the early 90's. As the high-tech boom moved forward there was more traffic on the road which created more noise. But as the commute hours ended, the noise level dropped correspondingly.
Since these houses were built post freeway construction, the houses sit adjacent to the freeway with a wide open space separating the road from the sound wall. This is better that the other way around where existing homes were 'cleared' in order to make way for the road, with the remaining houses sitting 5 feet off the freeway edge.
After a while we actually stopped hearing the roadway. This doesn't mean that it went away. It just means that after a time it pretty much disappeared from our personal perspective. We have enjoyed living where we do and have no regrets. I don't hear many 'big trucks' late at night. Maybe a few. I guess we haven't noticed.
Also, where the houses are further away from the actual roadway (as in your case and ours), the concern over road pollution turns out to be not much of one. Be prepared for people to start screaming that I said it's not a concern. They're right and wrong at the same time. However, I'll say once again that they do not live here and speak from fear (or sometimes made up statistics). They don't want this in their Back Yard. They don't want anything in their Back Yard. They are afraid and therefore give you their fears as 'Good' advice, without considering all the points.
I think I'm a little more pragmatic. And pragmatically speaking, this is the Bay Area. We have Spare The Air Days all the time. There is no place you can live in the Bay Area where you will not be exposed to air pollution. The concern here is not that you may be exposed. You will be exposed. The point is how much exposure. In your case, the freeway is not right next to you, as with older construction. The predominate winds blow from the West. You are upwind from the roadway. And on a personal basis, according to our doctor, we have never experienced and medical problem related to the freeway. We moved from the LA area. Talk about daily exposure to pollution. Next to a freeway or no, that was bad. Pragmatically speaking, things are pretty good here in Pleasanton and we've had a good life.
Houses near a freeway generally are lower priced, but not greatly 'discounted'. Many people enjoy the easy freeway access (it beats driving across town to go and return from work, as I have had to do in the past). That could be a benefit for you at the moment. As business continues to improve I think the house will increase in value, just like all of the other houses in the area. The only houses that are not increasing at the moment are in the hills and priced over $1M. They seem to remain in a slump. The neighborhood that your looking at was middle management income level family neighborhood that last I saw. It may have changed. Drive by after work and take a look.
Jenny, I think that's all I can offer. I wouldn't be afraid to buy the house. If it's in your budget, and you like it, it could become a great home for you. But don't take my word for it. I'm sure there will be plenty of people willing to chime in with their advice.
Weight the pros and cons for yourself. Good Luck.
a resident of Another Pleasanton neighborhood
on Jul 16, 2012 at 1:16 pm
Jenny: You obviously need professional help -- i.e., a good Realtor! You also need to take a good look at a map; if freeway noice is a problem for you and your family, then you can easily see the neighborhoods that you might wish to overlook. We have NO "bad" neighborhoods in Pleasanton -- just different prices, ages, amenities. Good luck in your home search.
A retired Realtor.
a resident of Another Pleasanton neighborhood
on Jul 16, 2012 at 1:27 pm
I think Bob has a well written post.
I do suggest that if you are concerned about noise, you visit the house as many times as you reasonably can (Not sure if it is occupied) at different times of the day, but that still doesn't always tell you everything. We moved near downtown a few months ago and I never would have guessed that I would be roused from my sleep by a train at 530 am every weekday. But you get used to it, I guess. I have also noticed that for us (near Bernal) road noise can vary greatly from front to back of the house, depending on which side faces the freeway.
Having moved a few times, I agree that one of my concerns would be that the house you are interested in is sitting while other have multiple offers. My agent/friend told me that most things that are sitting, are doing so for a reason. I guess it depends on how long you plan to stay and if you are able to make changes (for example, if a house is sitting because it is outdated... you can change that. But you can't change a location). If you plan to stay a long time or if the market turns around, you will probably realize some gains anyways or will be able to sell for less than others around you.
If you are going to be here a shorter time, I would consider resale value more seriously, as you will want to be able to sell quickly at a good price. Commuting and proximity to freeway is good too. I would also consider the age of your children, if you have them. If your neighborhood is more remote, you will be driving further to friend's houses/activities/school, etc. That doesn't bother some people. Some people it does.
That's my two cents.
Good luck!
a resident of Valley Trails
on Jul 16, 2012 at 1:37 pm
Pleasanton offers more than what you are reading in this blog. Please ignore those who have nothing but negative information to share.
We have lived in several neighborhoods in Pleasanton since moving here about 12 years ago. I would say they all had pros and cons and no matter where you decide to settle down here in Pleasanton you will never be 100% satisfied, even my friends who live in the high end neighborhoods like Ruby etc. aren't happy with one thing or another its just what are your willing to live with and live without.
I'm sure once you find the home for you and you're family you will make it work. I currently live next to the sound wall whre 680 runs and when we first moved in I could hear it, now its just part of my daily living, turn up the music in the backyard plus screams and happy sounds from your kids will help all that fade away.
Good Luck.
Being Nice
a resident of Another Pleasanton neighborhood
on Jul 16, 2012 at 2:45 pm
The actual term in Ca. and most states is "Real Estate Agent".
"Realtors" are just members of a private association.
Sounds like "Doctor", doesn't it?
(but not the kind that's good for anyone? :-)
The term was in general use to describe salespeople, brokers, etc, when it was "trademarked" in the '50's by an Ass'n, called the NAR- who now set the terms for most Multiple Listings, controls the data, and issues the title to people who apply and pay them.
Their control of the listings is one reason they have been so effective at keeping their commissions so high. Now that the Internet can provide the same information to anyone, this should change.
I've bought several houses without a Real Estate professional, for less and without hassle. You don't need to know that much to point and say: "And this is the kitchen"-while pointing to the den!
Mostly Realtors try to keep their members from selling services at a reasonable price, or charging by the hour for work that is actually done.
In California, the state licenses brokers, agents, salespeople. Make sure your professional is state licensed - and you can check their status on-line.
"Realtors" have no more standing than any others.
Also see:
Web Link
a resident of Oak Hill
on Jul 16, 2012 at 5:14 pm
resident said: "Do posters who complain about pollution from the freeways not own a car/vehicle - you get pollution from the car sitting in your garage/driveway - cars are everywhere - so it doesn't necessarily have to be any different whether you live near a freeway or not - your neighbour might have a gas guzzler/turbo charged/suped up car etc and then you complain about freeway pollution - get over it! "
It's been well documented that pollution levels near a freeway can be relatively high due to the high volume of high speed traffic with car and truck engines operating at high rpm. Your "cars are everywhere" argument is a bit simplistic.
a resident of Another Pleasanton neighborhood
on Jul 17, 2012 at 1:29 pm
@Sam - I wasn't trying to suggest living near a freeway is just as healthy as living in a field in the country - just stating it's hard to get away from traffic pollution in Pleasanton period no matter where you live. There's simply not many neighborhoods in Pleasanton that you can live where there aren't many cars driving on the roads nearby - whether it's Hopyard, Santa Rita, Valley, Foothill, Stanley, etc - all these roads lead to the sub-division housing developments - there's no getting away from it - cars are everywhere - yes I agree more are on the freeway but to the posters who constantly complain about freeway pollution, you're likely to still get high levels on the other main roads where there are thousands of cars everyday.
a resident of Oak Hill
on Jul 17, 2012 at 4:54 pm
resident said: "yes I agree more are on the freeway but to the posters who constantly complain about freeway pollution, you're likely to still get high levels on the other main roads where there are thousands of cars everyday."
I understand your point. There's no escaping some degree of air and noise pollution living in this area. I never understood why pollution from a freeway was any worse than that from a heavily traveled city street (e.g., Hopyard) but, on reflection, I think that I do see one big problem with freeways over heavily traveled city streets from an air pollution standpoint: The cars are traveling much faster on freeways. Why is this significant? Because the force required for a car to overcome air drag increases greatly with increasing speed. If the speed of a car doubles from, say, 30 mph to 60 mph, then the amount of air drag on the car approximately quadruples. That means that the engines in all those cars you see whizzing by on I-580 or I-680 are working much, much harder than cars rolling down Hopyard and, consequently, each of those cars on the freeway are putting out a lot more air pollution per mile than the typical car on a Pleasanton street.
In addition to that, there's the traffic makeup: Heavy trucks tend to be much more common on I-580 than on the typical Pleasanton city street.
a resident of another community
on Jul 17, 2012 at 5:37 pm
With all due respect, Sam, aren't you being a bit dramatic? I realize you may have some limited knowledge on this matter, but you must realize there are other perspectives. I mean, for gosh sakes, isn't it a bit elitist to use your knowledge to spoil American's God-given right to inhale petroleum fumes that are at the basis of our modern economy? Next you'll likely be preaching at us about the horrors of global warming, something that scientists and corporate spokespeople have had many good conversations about. But as far as petroleum fumes, purchased fairly on an open capitalist market, I've never worried about them myself because my magic happy underpants has always afforded me much protection.
a resident of another community
on Jul 17, 2012 at 6:03 pm
Let me also add, retroactively, that my party does not dote on little people with their little afflictions like cancer and black lung. Why only today my party is sending a message that profits for our wealthy campaign contributors are far more important than the lungs and lives of America's coal miners. The recent investigative reports by several biased left-wing news organizations on the devastating impact of black lung and the lengths that some mine operations go to circumvent their responsibility to protect miners has been meant as "a wakeup call." But, as only fitting, voices wealthier than coal miner families have successfully drowned out that message. [...] Blocking efforts by the Mine Safety and Health Administration to modernize miner protections may cost a few lives, careers, and family income for those who go underground every day, but that is piddling compared to the profits our job creating heroes in the mining industry stand to lose if further state mandated regulations go into effect.
Mitt -- I'm for freedom. Freedom to make a profit. Freedom to drown out voices of the little people.
a resident of Downtown
on Jul 17, 2012 at 6:06 pm
I live downtown and have no problem with the road noise, the trains or the concerts in the park. My previous home, in another town, had none of those things. What it had was a neighbor with two pre-teen girls and a swimming pool. Absolute hell on earth. Little girls scream, their friends scream and they never stop. There were sleepovers with 20 kids nearly every weekend. Then the other neighbor would turn up his backyard stereo speakers.
Yup, I'll take freeways, trains and live bands any day to a couple of screaming brats.
a resident of Another Pleasanton neighborhood
on Jul 17, 2012 at 7:46 pm
Thank you for the input. Interestly since the first poster mention ruby hill , we actually live in Ruby Hill currently. It's a nice neighborhood but it is far from everything. We looked at many houses, from east Dublin to San Ramon, and finally back to Pleasanton. This is only the second time we are looking for a house, but we learned that no matter where you choose, there are alway some compromises, be it small lot, floor plan, age of the house, commute, neighborhood, hight tax and hoa etc. We decided out of everything, noise is the easier to take. At least the house itself is very nice and it is easier to commute to work. And the noise inside the house is very minimal. Except the noise from the freeway, the whole neighborhood itself is pretty quiet, not a lot of traffic and people.
People live in places like New York, LA , Tokyo, Hong Kong etc deal with noises everyday and houses next to a busy street or highway don't sell less... Sometime even more. So after all people's tolerant of noise is more than most people think.
a resident of Vintage Hills
on Jul 18, 2012 at 3:16 pm
AS you can see from these posts this is not the nicest city to live in. I moved here 2 years ago and regret my decision every day. Hopefully, I can escape this hellhole and move to San Jose where people are nicer, more tolerant and there are people who don't blame everything on the democrats or obama. Good luck with your search!
a resident of Another Pleasanton neighborhood
on Jul 18, 2012 at 10:59 pm
I'm with you Chris.... I've moved here recently and I hate it here everyday. People are miserable and snobby. I WISH I could leave... can't afford to sell my house and hubby won't go. Do I stay and be miserable or do I leave divorced.... it's a hard decision.
a resident of West of Foothill
on Jul 19, 2012 at 11:27 pm
Used to live a street up from 680. If you like noise and dust then go for it. It was a long and difficult house to sell. Buyers were turned off by constant noise. Good luck with your decision.
a resident of Canyon Creek
on Sep 6, 2012 at 10:52 am
About a year ago, and after seven years of living in a very large beautiful custom home in Ruby Hill - in south east Pleasanton, to this three times smaller home on Canyon Creek Circle - in north west Pleasanton. But to say the least we are far more happier here despite the freeway noise and a non-gated community. All amenities are within a five minutes drive and the culturally diverse community here is wonderful with kids of all ages. Traffic, pollution, noise, etc. are a given and pretty much anywhere in our bay-area, but Pleasanton has a lot of better schools and living to offer than most other cities. You have to weigh the pros and cons. Good luck on your search, Jenny!
a resident of Canyon Creek
on Jan 27, 2014 at 10:02 am
SO I guess this topic has been dead for the better part of many months. But if some one else lands up here you should know the facts.
1. There is some amount of noise through the day.
2. Through the night, there isnt as much noise but you will hear the occasional 18 wheeler trying to slow down on the slope- it doesnt really bother us and we sleep with the windows open.
3. Canyon Creek is surrounded by greenery and hills on all sides- the additional Oxygen from the trees should count to offset some part of the added pollution.
4. Inside the house, there is almost zero noise.
5. The community is wonderful and the houses are premium quality.
6. Getting in an out of this community has never been a problem. Id like to call Maggie's bluff here. The only way she would ever know if there was a problem getting out is if she lived here. Driving past the community on Dublin Canyon Road typically will take her 3 seconds to pass the waiting cars. She has no idea how long they wait or if they wait even.
7. Every house has a price- the freeway noise will account for it when you buy it and it will be accounted for when you sell it. The house you mentioned sold for 70k above asking inspite of a small size layout and the concerns you mentioned.
Overall, great community with the minor distraction that is the Freeway noise and it sounds more like a beach with constant waves :P
a resident of Oak Hill
on Jan 27, 2014 at 12:26 pm
Every house in Pleasanton has its plusses and minuses. I'll freely admit and tally some of the ones my west Pleasanton (Oak Hill) neighborhood has:
- Nice view of the hills on the west side of Pleasanton.
- Easy access to both 580 and 680.
- Fairly convenient access to both the Mall and to Main Street by means of Foothill and Bernal roads.
- Far from the train tracks and midnight train whistles (can hear them sometimes at night, though - how do people who live downtown deal with that? :-) ).
- Being partially on a hillside at higher elevation, will probably be one of the last locations in Pleasanton that will be underwater in the event of a 500-year flood.
- Some freeway noise from I-680.
- Close to the Calavaras fault running up Foothill Road.
- Close to Foothill High School's football field with their Tuesday afternoon marching band practices.
- Close to a high school which holds an annual "Battle of the Marching Bands" event lasting until about 10pm. (move this item and the previous item to the 'plusses' category if you love marching bands).
- Next to Cody Hall's favorite drag-racing strip (Foothill Road).
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|Topic Review (Newest First)
Good choice on the food switch!
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|It likely just built up. When he gets older, he'll have the muscle in that area that it will expel naturally for the most part when he defecates, but as puppies they have less muscle mass in that area and sometimes need help expressing it. If he is to the point that he seems uncomfortable, I would definitely get them expressed either by you, a vet, or a groomer. It's a simple process, but if you put it off and let that fluid build up, it can get impacted in the anal gland and cause more serious problems.
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|I agree with you that is not the new food. Probably his anal glands need to be expressed. This explains how to do it: How to Express a Dog's Anal Gland: 7 Steps (with Pictures) Or the vet can do it instead.
Anal Gland issue Is it the Orijen?!
I just switched my 4 month old pup, Loki from Diamond Naturals LPB to Orijen LBP 10 days ago within the next few days I started to notice he had that fishy anal gland smell, has been licking his butt, and squeezing liquid out before he eliminates.. (yukk sorry, tmi) Its been more noticeable the last few days The only other thing thats been different diet wise is i have been giving him carrot for treats he goes nuts over them! Also stopped giving a small spoonful of greek yogurt per day.
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And also, should I take him to the vet to expel it or see if it resolves? It doesn't seem to bother him so much at this point.
Any input would be greatly appreciated
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The National Weather Service in Salt Lake City issued a winter storm watch Sunday for much of Utah ahead of the next wintry blast expected to sweep into the state.
The winter storm watch, which begins Monday night and will last through Wednesday afternoon, is in play for southwest Wyoming and the western two-thirds of Utah, except along the Arizona border.
The snow will begin Monday night along the Idaho border and move south into central Utah during the day Tuesday, the weather service said.
The snow is expected to pick up Tuesday night into Wednesday.
It wasn't known Sunday how much snow is expected to fall, but the storm is expected to grow stronger as it moves into central and southern Utah.
Temperatures are also expected to plummet starting Tuesday. Tuesday's high is expected to be 34 degrees while Wednesday's is expected to be 25 in Salt Lake City.
The weather service said even light snow with this system will probably accumulate on roadways since it will be so cold. Travel will be "significantly affected" Tuesday and Wednesday, the weather service warned.
But for those looking to enjoy the sunny skies and more moderate temperatures ahead of the storm, Sunday marked a good day for outdoor enthusiasts looking to tackle the slopes.
There is a low risk of avalanches along all of Utah's northern and central mountain ranges, according to the Utah Avalanche Center.
The only downside is the air quality, which was listed at a "moderate" level both Sunday and Monday.
But the wintry blast was expected to fix that too. By Tuesday, the air quality is expected to return to "green" or "good."
Reporter Michael McFall contributed to this story.
Twitter @sltribjanelle


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Has the death of newspapers been exaggerated?
November 19, 2012 , 5:33 PM by Patrick Mitchell
After graduating from University, Emily Gash took a job as a reporter for Nhill Free Press in the Wimmera.
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Emily and her partner Daniel Gladdis purchased Nhill Free Press from Craig Wilson, who also owns a number of rural newspapers including the Pyrenees Advocate.
It comes amid difficult times for the media industry with Fairfax and News Ltd forced to cut costs as new media eats into their advertising revenue.
But Emily Gash says the future is bright for country newspapers.
The paper is searching for a new reporter and Ms Gash says advertisers remain committed to the paper.
"I think it will make money," Ms Gash said.
"The towns of Nhill and Kaniva love their local paper."
Listeners from other parts of Victoria agree that country newspapers will survive.
Alan from Hopetoun called in, he says his town's local paper was saved by a co-op of loyal readers.
Have a listen to today's interview with Emily Gash and some of the talkback calls we received.
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This was an issue during my first outing with my full costume on at my local con: My back plate and the attached collar plate rides up between the jetpack and the jetpack harness as I walk around. I use a Kcrp7r harness (V1.0, I think), a Fett Seven fiberglass jetpack, and RKD vac-formed armor. I think that the round cutout at the bottom of the backplate is too small for the harness to properly protrude through. Because it is such a tight fit (even tighter once the jetpack is mounted) the backplate gets pushed upwards as I walk around and gets pinched in place. It creates a ridiculous 'no-neck' look. To top it off, my neckseal dickie gets all untucked when this happens. :facepalm
I am considering widening the hole at the bottom of the backplate. I am hoping that the harness will fit through the wider gap without the jetpack mounting tabs pinching themselves against the backplate.
I am also considering putting a couple carriage bolts through the harness' tube frame and through the backplate to prevent the backplate from moving upward. I cut out the access panel on the back of the jetpack and haven't found a good way to mount it back in place. This big hole in the jetpack would be an ideal spot for the bolts to protrude through the backplate.
I am also considering shortening the harness' lower mounting tabs at the bottom. Shorter tabs should mean that they won't get pinched between the backplate and my back. No pinching should mean no need for the backplate to push up to relieve the force.
Solving the neckseal problem is a no-brainer. Velcro, snaps, or outright sewing it to the flight suit is a solution I've heard mentioned many times. I simply thought it frivolous and unnecessary until now. :rolleyes I'll be taking care of that tomorrow.
However, I'd like to hear the community's experience and ideas before cutting away parts of this rather expensive costume. ;)


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CSF glucose
This test measures the amount of glucose, or blood sugar, in your cerebrospinal fluid (CSF), the fluid that surrounds the brain and spinal cord. People with serious infections that have reached the brain or spinal cord usually have lower glucose levels in their CSF than healthy people do.
This test is usually part of an overall look at CSF to help diagnose a central nervous system disorder or infection. Normally, your brain is protected from any germs in your bloodstream by a thin barrier. But when you're sick, this blood-brain barrier can become leaky, allowing bacteria and other substances to pass through. Bacteria, viruses, and other germs can then reach your spinal cord and brain, which could cause brain swelling and nervous system infection.
You are likely to have this test if you have symptoms of a possible brain or central nervous system infection. These include:
Severe headache
Sensitivity to light
Changes in consciousness
Neck so stiff that it's difficult to bend forward
Babies also often have their CSF tested if a healthcare provider suspects they have a serious infection that could cause swelling and damage the brain.
Your healthcare provider may also order other tests on the CSF sample, depending on what condition you have. These tests include:
Bacterial Gram stain and culture. The laboratory grows a culture from a CSF sample to find out whether you have an infection.
Viral culture of CSF
CSF-blood glucose ratio
CSF protein concentration
CSF leukocyte , or white blood cell, count. It's usually high if you have an infection.
Blood culture
Many things may affect your lab test results. These include the method each lab uses to do the test. Even if your test results are different from the normal value, you may not have a problem. To learn what the results mean for you, talk with your healthcare provider.
Results are given in milligrams per deciliter (mg/dL) or millimoles per liter (mmol/L). Normal levels of glucose in the CSF are 50 to 80 mg/dL, or 2.8 to 4.4 mmol/L. If your levels are different, you may have an infection.
Your healthcare provider will look at your CSF glucose level along with the other CSF tests, and possibly other tests, to better understand what your results mean.
This test requires obtaining a sample of your cerebrospinal fluid. Your healthcare provider will take the sample through a lumbar puncture, using a thin needle. The needle will be pushed into your lower back, and fluid will be removed.
A lumbar puncture carries these possible risks:
Some medicines, foods, and beverages may affect the results.
Your healthcare provider may ask you not to eat or drink for four hours before the test. Be sure your healthcare provider knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illicit drugs you may use.


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Travel Blog Some Tips on your Next Vacation.
1. Check in a day early. Online check-ins should be done 24 hours prior to your flight's departure. Don't forget to include emergency contact information.
2. Catch a ride. If possible, have a friend or relative drop you off at the airport to avoid paying parking fees. Also, be sure to work around your driver's schedule and consider the time of day in order to beat rush hour traffic.
3. Be on time. For domestic flights, it's a good idea to arrive at the airport at least two hours in advance. If you're flying internationally, plan on showing up at the airport at least three hours in advance. Remember that during peak travel times, there will usually be lines for both luggage check-ins and security screenings.
4. Avoid peak travel times. If you can, avoid booking flights on Fridays, Sundays and on Monday mornings, which are peaks times for business travelers and those returning from vacation. Other peak travel periods include on weekend evenings.
5. Make a copy. When traveling out of the country, make sure to keep your passport locked safely in your hotel room. When away from your room, carry a photocopy of the identification section with your picture in case you lose the original. Having this copy can also expedite replacement if your passport becomes lost or stolen.
6. Slip past detectors. To get through security screenings quickly, it's a good idea to wear slip-on shoes such as flip-flops or sandals and avoid wearing metal belts or excessive amounts of metal jewelry.
7. Bring it on board. To avoid a hassle if your checked luggage gets lost or delayed, your carry-on luggage should include a clean change of clothes, pajamas, a toothbrush, toiletries (under three ounces) any necessary medications and, if you're staying at a resort or near a beach, a swimsuit.
8. Pack lightly. To avoid paying more for checked luggage, travel light and pack smart. Roll your clothing to save more space in your bag. Only pack three pairs of shoes at most, two casual and one dressy, as well as clothing of similar or neutral colors that can be easily combined to make multiple outfits.
9. Avoid a decline. When traveling far from home and especially when traveling internationally, make sure to call your bank and credit card companies to let them know where you'll be to avoid having a credit or debit card locked due to a fraud alert. If you are traveling overseas, order a Travelex or similar card to easily convert U.S. dollars to foreign currency.
10. Know where you're going. Travel agents said one of the most important keys to avoiding a hassle when traveling to an unfamiliar place is to educate yourself on local culture, custom and etiquette, as well as tipping policies.
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Posts Tagged 'Amanda Field'
Brooklyn + Poets + Moms! April 5, 2013: The doorbell rings. Amanda's here, with Beckett (4) and Scarlett (3 months). We lug the kids and their attendant gear up three flights of stairs. As soon as we're all settled inside, the [...]


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|Topic Review (Newest First)
|I'm with 4 Jaw....not because he's a moderator but because I'm a 30 year machinist and have been there done that. The lathe I have now is a 15" Leblond Regal and really like to have one a bit bigger one but that's what I have. It was 6000.00 back when machines were bringing decent money (early 90's) and the same machine today might only bring 3000. Once the economy takes off again, and it will, machines will go up again. The Regal isn't a heavy duty machine but it's a good precision unit and does well and has been reliable. It does all I ask of it and more. I just hope it doesn't break down because it won't be cheap to fix lol
|4 Jaw Chuck
The countershaft plate and motor mount has the second set of gearing so you can just shift the belt from pulley to pulley to get different speeds, typically this is done by releasing the pressure on the belt by pulling a lever and then moving the belt on the countershaft to another pulley. Have a look at this forum page for pictures of other lathes, all lathes do the same thing so will see how other manufacturers build their machines.
I don't want to discurage you but what you have there is someones attempt to turn the lathe into a wood lathe, hence why the bull gear and countershaft plate is gone...seen it before. The amount of money spent trying to find parts (the shipping is what kills ya, its heavy!) and restoring the unit is not worth it.
However if all you intend to do is turn at one speed and one feed, then what you have will work...especially if you don't have the feed gearing stack. Having worked with the exact unit you have there I can tell you trying to accomplish work with such an old style lathe is an exercise in frustration, you will forever be working around its shortcomings.
I suggest you take a course at your local college and work with their modern machinery and get some experience, learning how not to lose fingers will be one of the more valuable lessons you will learn. They will have an old unit some where you can try out and you will see how much hassle it is to work with.
If you need to polish a shaft or just turn a diameter what you have will work just fine, many shops I worked in had an old lathe in the corner (just like what you have) for polishing since the abrasive is hard on the lathe ways of the good equipment.
Just be realistic about what to expect from what you have there, it needs a lot of work, it is missing most of the parts that make a lathe useful, the spindle won't have a large through hole so what you can chuck is limited, and you have no tooling to start with.
Take a course, once you do I think you will see what you have is largely a heavy chunk of iron.
Good forum for machine tools, nice guys, lots of knowledge..
There is a forum for antique machines and a Southbend specific forum too.
You might be able to find the gears for your lathe there too, or at least get an idea what they look like...
When I bought my 14x48 Graziano the folks there were very helpful in filling in some of the blanks.
Learning lathework is fun, even if the machine is a million years old...
I had a 1922 Lodge & Shipley 14 x 60 and was going to restore it, but lost interest when I got my 59 Sheldon and spent my time making chips instead of fixing machinery...
A while back a guy offered me a fairly large Leblond, ( all he said was it was WAY bigger than my 14x48 ),all in pieces, ready to restore...All I had to do was go pick it up, but I really don't need another 6000 pound jigsaw puzzle...
Ebay is a good place to pick up tooling, with a bunch of surplus machinery and tooling out there it sells for almost pennies on the dollar.
Later, mikey
Considering you don't have anything in it you should not be at all disappointed. Sure it will be limited as to what you can do but it will be far from useless and you can learn the basics plus you do have a valuable antique, not worth a large sum but not at all worthless either. This thing can truly be a learning experience and as long as you don't invest a lot of money in parts/tooling that would be specific to that model what you do spend will transfer over to that newer lathe that I am confident you are going to be looking for soon!
Whatever you decide don't trash that old machine as there definitly are people out there that would love to have it, just as we here like to work with old cars there is a fairly large group that is dedicated to old shop machinery.
It is starting to sound like I would be better off without this thing, which is disappointing, but I am sure another one will come along at some point.
Thank you for all of the helpful information.
- Josh
lathe stuff
I can't see who wrote this but someone mentioned that you would be better off w/a modern lathe...we'll, yeh..And more monetarily challenged too!..No fooling, the modern lathe would be mo-betta, but which one....I suggest you get the small lathe going and maybe even practice w/it on the nights when your not in your Basic Machining class..Once you have a clue about what the lathe will do and what you wanna do w/it {comes w/time on the lathe} you will be better equiped to make a informed decision...In a machining class you'll be surrounded w/people who will challenge and inform you..You'll probably be rubbing shoulders w/people who work in machine shops and ,just by assoication,will open new doors for you.Knowledge {like a dumb question} is cheap...dumb mistakes {unlike dumb questions} are expensive.
Someone said machining is addictive...yes it is..it's alot like having a bottomless toybox out in the garage..
G-luck, Randy
|4 Jaw Chuck
It was free for a reason.
|Imo, that lathe will only frustrate you. If it were me, I'd clean it up, make it operational and sell it and then go look for a more modern machine. With the weak economy, there's lots of deals to be had but there might be someone that is out looking for a collectors piece and will buy yours. I have no idea if a collector's market even exists but a modern machine has so much more to offer and will be much easier to operate and consume less time doing it. But if you decide to keep it, read up on lathe safety so you will at least be aware of the dangers. Even a small lathe can do major bodily damage. No loose clothing, no long sleeves, gloves or long hair. Learning how to run a lathe is a long time experience and some old timers will say they have forgotten more than a newbie will ever learn lol
Tool prices can be rough and the initial cost of the lathe can be the cheapest part.
I bought a new Chinese Lathe (14x40) rather than try to rebuild my well used older 16" machine and so far it is doing just fine, I have found that the larger import machines from 12x36 on up are not at all bad, certainly not even in the same ballgame as the old American/European iron but quite usable (and affordable) anyway. I kind of figured 4 Jaw would weigh in on this one and sure enough his usual wealth of knowledge put everything in a much clearer perspective! There is more info in that one post than I have seen on these old machines anywhere and as common as they seem to be we need to save this post for possible future reference.
|Try Wholesale Tool at www.wttool.com many of their prices are good.
I was really shocked when i went out to buy tooling for my Lathe, I paid $400 for it (12x36 Taiwan made , but pretty nice for 4K) and almost that much for the quick change tool post..... Prices are horrid.... I look at the on-line auctions for tooling now, much better......
|4 Jaw Chuck
Thats a South Bend, prewar...if I had to guess I would say circa 1911.
I used one identical to her (all lathes are women BTW), the shaft below is for bench mounting with a countershaft...back in the days when shops had powered countershafts running through them from an outside steam or electric motor.
She needs a lot of TLC before I would even put power to it, those babbit bearings won't take carbide speeds so stick to HSS. Hope you got the gears with it so you can change feed, kinda limits the usefulness without them. It needs a good cleaning, when adjusting the gears on the feed use a strip of paper to get the clearance right, those old gears tend to not run true on the pitch diameter so don't run it too tight.
A quick change tool post is nice but on these old lathes the carriage keeps the original post bolt so far from the spindle centerline you will need special holders for the tool blanks. With this lathe we just used the original tool holders and just inverted the cup under the post to hold the tool flat, you need to be able to reach out with the tool holder and need the length given with the original tool holders.
Don't go nuts with power, they don't have the rigidity for over 2HP...remember in the old days they used light cuts and slow feeds, flat belts slip at high horsepowers so even though the vee belt retrofit you have already is capable of transmitting more power don't do it.
My eye twitches when I see this old beauty because I spent more time playing with them than I ever wanted to, keep the spindle bearings well lubricated and adjusted properly (its shimmed), get it mounted straight and clean it up and she will turn lots of work for you.
BTW STP mixed 50/50 with 10wt mineral oil works great for a spindle oil and helps with vibration, we replaced the drip feed cups with felt wicks in the headstock to extend the time between lubricating the spindle...constant squirts from the oil can to fill the cup are a PITA once the spindle babbit is worn.
Here's a similar one.
|406 bug
I just looked at what seems to be the oldest Clausing model. They say it has roller bearings on the spindle. Mine has Babbitt bearings. Do you know if they had different options or if I need to keep looking?
Speed Ranger
Style #112774
Size 742Q
Const. orque 7.5 Inch-Pounds
The bottom plate is the list of approved oils and some cautions
On top of the motor:
Master AC Motor
Type RA
Cont. Duty 40 (degrees) C
1/2 Horse
Also, on the underside of the table it has 13 190 cast into it. The 3 is difficult to read and could be a different number.
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News Release
Media Contact: TPWD News, email@example.com, 512-389-8030
Feb. 10, 2009
Texas Independence Day Celebration Slated Feb. 28-March 1 at Washington-on-the-Brazos State Historic Site
WASHINGTON, Texas — The 173rd anniversary of the signing of the Texas Declaration of Independence will be commemorated Feb. 28 and March 1 at Washington-on-the-Brazos State Historic Site. The free, two-day celebration, held from 10 a.m. to 5 p.m. daily, brings to life the early 1800s Republic of Texas era.
The two-day celebration at the 293-acre park along the Brazos River transports visitors back to the time when Texas was a sovereign nation. Costumed re-enactors and members of the Texas Army, along with skilled craftsmen and talented musicians, fill the park as Texas commemorates its inception. Re-enactors portraying statesmen of the era, such as Sam Houston, Stephen F. Austin and Anson Jones, will be on hand to explain the importance of Texas independence. On both days, vendors will be selling a variety of festival foods and drinks.
The Washington-on-the-Brazos Park Association's new Web project, the Spirit of Independence, will be previewed at the park's Visitors Center. The interactive Web site is being constructed to allow teachers and students access to the historic site's wealth of information and primary sources. The Spirit of Independence project is designed to increase awareness of the unique place Washington-on-the-Brazos holds in Texas history.
Also on Independence Day weekend, the Star of the Republic Museum at Washington-on-the-Brazos will open a new exhibit titled "Texas Transformed: Early Maps of Texas." On display will be the largest map of Texas, measuring roughly eight feet square, on loan from the Texas General Land Office. Charles W. Pressler, who worked for GLO for 50 years, drafted the map in 1879. The Pressler map will be exhibited through March 22. Other rare maps, including the first to identify "Tejas" as a place, will be on display through Aug. 31.
At 11 a.m. on Sunday, the park association and the Ron Stone Foundation will dedicate a marker and rose garden to the late Ron Stone, an ardent supporter of Washington-on-the-Brazos. The Antique Rose Emporium will unveil Ron's Vision, its newest yellow rose.
Dr. Stephen L. Hardin, professor of history at Victoria College, author, and widely acclaimed expert on the Texas Revolution will be the guest speaker at 2 p.m. Sunday in the park amphitheater. Following will be a performance by the Tanner Family Minstrel Show. In keeping with the celebration's tradition, a Texas-sized birthday cake will be served to concert-goers with the help of the Washington County Historical Society Heritage Belles.
Washington-on-the-Brazos State Historic Site features three attractions that are open year round: Independence Hall, the Star of the Republic Museum and the Barrington Living History Farm. Admission fees to all attractions will be waived during the celebration weekend thanks to support from the WOB State Park Association, Exxon/Mobil Corporation and Bluebonnet Electric Co-op.
Washington-on-the-Brazos State Historic Site is located between Brenham and Navasota off State Hwy. 105 and FM 1155, approximately one hour northwest of Houston.
For directions or more information, call (936) 878-2214.
On the Net:
- http://www.birthplaceoftexas.com/
- http://tpwd.texas.gov/spdest/findadest/parks/washington_on_the_brazos/
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|Topic Review (Newest First)
Thanks, Dan!
I'll be sending you a sample of both buffalo colors I'm going to be using in the interior; Dark Chocolate (which they call "black") and Cream (which they call "palomino"). If you can hook me up with matches for making buttons, it sure will help me out.
I'll be using the larger 3/4" buttons on the backs of the seats.
Alan: You should be pleased, they turned out great! I love the way you're doing the back of the seat backs with the buttons. Send me a piece of the buffalo hide that you want to match, and I'll see what I have in my arsenal to make buttons out of. What size buttons are you going to use?
I can't tell you how good it makes me feel that you guys are succeeding at doing this!
I'm finished with my seats -- I wound up using buffalo hides and I couldn't be more pleased!
Here's a picture of the Before & After:
And here's the whole photo-tutorial, from start to finish:
The whole project spanned a period of ten days and I found a whole new level of respect for you pro's! Man, I'm tellin' ya ... I'm real pleased with the way they came out, considering this was my first time and I didn't make any serious blunders, but I wouldn't want to do it a second time. LOL! My hands are killing me! This is, seriously, TOUGH work!!! Sewing those French seams around the parameters of the seat backs and bottoms was nearly impossible!
Anyway, the best part is, I did it and I did it well ... buffalo hides have the most beautiful grain on the planet ... and the most difficult part of doing my truck interior is behind me.
Special thanks goes out to you, Dan D., for all your wonderful help and support.
Well, my project is moving along.
Here's the start:
Then, a couple of days ago, I covered the seat-back handles:
And yesterday I covered the seat side control modules:
Merry Christmas everyone!
Thanks, Dan. I'm psyched! This is gonna be such a fun project.
Now I need to calculate how many hides I'm gonna need to do the whole interior.
|Yes, the sew foam will keep the leather parts from stretching. That's why I sew the perimeter parts to 1/4" sew foam too. I used to do that just for leather, but now I do it for everything. It just makes a higher quality job, keeps the parts from stretching too much, and pads the parts that touch the seat frame to prevent the seat cover from being cut if bumped.
Report on Buying Hides: I called both leather suppliers (listed/linked to above) and The Hide & Leather House had the best prices by far! Elk hides, being approximately 20 square yards, are $160.00 each at The Tannery compared to only $100.00 at The Hide & Leather House ... and The Hide & Leather House assured me that these were top-grade hides (the Tannery did not)!
Also, The Hide & Leather House seemed to be much more knowledgeable ... he was concerned that I was using elk hides for seats and said the elk hides, like deer hides, stretch too much for this type of use. I told him I would be using sew-foam to compensate for that and he didn't say any more.
Is the sew-foam going to help keep the elk hides from stretching too much? Or is it possible I'm making a mistake here?
Thanks, Dan. I hadn't thought about condensation -- that's another *really* good reason not to do that bagging routine.
Honestly, I didn't think it would come to that because, like you pointed out, these seat backs are obviously not going to be a battle; they are, from top to bottom, a straight run that gets wider as it goes down.
PS - I bought a compressor yesterday so I'm ready to use my glue gun!
No problem with using a strip of plastic on the edge of the seat back. I'm talking about covering the whole thing in plastic which isn't necessary. I also know from experience and the style of Alan's seats that they will go together with no problem without using any plastic at all. Remember, the seats you are copying were made on a production line where speed is just as important as quality. I'm trying to get you guys to think in terms of making custom seats, where "good enough" isn't good enough and taking any extra 10 minutes to put a seat cover on will teach you a lot more than slamming something together as fast as you can.
What I'm trying to get across to you guys is that if you do the seat covers right in the first place, you won't need to heat anything or steam anything. The only thing I use my steamer for in my shop is to form carpet. I use my heat gun to make vinyl repairs.
Mark: I'm sure when you worked on dental chairs you were using contract grade vinyl like Naugahyde Spirit Milenium which is very heavy, stiff, and hard to work with, and made to take a beating and be impervious to staining and yes, steam and or heat would help with that situation. The modern vinyls, 100% polyurethanes like Ultraleather, and leather are soft and pliable, and don't need heat or steam.
|From the factory my seats came with a 5" strip of plastic all along the outside edge. I cut a heavy-duty garbage bag down the middle, 5" wide and about 55" long. Slight mist of foam spray on the plastic and installed it by following the outside edge of the seat top and wrapping all 3 sides. I am not recommending this to anyone. I did it because that is the factory way for my seats. Made things very easy to slide on and allowed lots of foam to foam contact so things wont shift, also no condensation problem.
See Alan? I told you Dan would have some input...
No offense taken, Dan. I wondered about that as I was typing it, and that's why I mentioned you, and the fact that I hadn't worked with leather yet. I was hoping you'd say something if I had some bad advice.
I do have a comment though. I did upholstery in a factory setting, as I may have told you - I upholstered dental chairs. We used steamers and heat guns all the time to get the vinyl (Naugahyde) to conform to the contours of the seat forms. Now please understand that I'm not questioning you, but isn't the use of a steamer and/or heat gun considered 'par for the course' when it comes to upholstery? Some corners are pretty tricky, and sometimes you don't want a wrinkle where it seems to want to be - you get my drift. Steamers and heat guns softened up the vinyl enough to kind of trick it into doing what you wanted it to do, whether it wanted to or not.
As far as a steamer 'reviving' seat foam is concerned, no - it'll still be 20 year old foam. But it'll sure be softer, puffier, easier to handle, and won't have that 'nasty old foam' smell. It'll also bring the foam back a lot closer to it's original shape.
Let me throw this one out into the universe.........plastic encourages condensation with temperature changes, and would trap any moisture that might develop. I've had this discussion before when someone asked if you'd need plastic under a seat cover in an open roadster that may get trapped out in the rain, and also in a thread about cleaning seat covers....... Look at post #18 in THIS THREAD to see some pictures of why I don't like plastic under seat covers. Also read post #20.
I love Hotrodders.com -- it's great to be back and into a good thread again!
Barry: LOL! Let me tell you ... if it was necessary, I would take up tanning!
Pope: That's a great link! Thanks! Dan also sent me one:
The Tannery: http://www.thetanneryinc.com/leather.html
Dusty: Thanks, Bro'. I was thinking about the inside-out routine and I will try that first.
Dan: Thanks for the heads up! PS - Have you ever heard of using bags from the cleaners before? I never tried it ... but it's something I heard a long, long time ago and filed it in the back of my head. It does make sense that sliding one of those bags over the seat before slipping your cover on would make things go easier ... I've just always wondered if you might hear crinkley-noises every time you shifted in the seat (THAT would suck!).
I have never heated or steamed a car seat cover to get it on in my life. If it doesn't look good after the first time you put the seat cover on, there is another problem that needs to be addressed. Steaming or heating is not a substitute for cutting and sewing the seat cover correctly.
Steaming seat foam may get indentations out of a piece of foam, but steaming will not completely revive old foam. Even the best seat foam loses its density over time, and nothing will make it come back.
I'm not trying to preach, and I'm also not trying to criticize you, Mark.
Welcome back Alan! Good to see you!
I checked out your site, and have a couple of suggestions for you. First would be to get hold of a steamer and go over your seat foam with it. It'll soften and puff up the foam and remove some of the dimples and divots left by the old upholstery.
Take care of that foam, BTW - it's expensive to replace. (I checked into new foam for the Chevy truck seat I did in class, and the cheapest I found was $300 - and that was just for the seat bottom!)
The steamer also sometimes helps out when it comes time to pull the finished covers over the seat. Heating up the corners of the new cover softens everything up and helps it to form around the contours of the foam. (Dan may have some input on this too. I have to say that I haven't worked with leather yet, so I don't know if steaming it is necessary when it comes time to pull a leather cover over the seat.)
The picture is the steamer I have, and I use it quite a bit for a number of things.
You may or may not need any of that plastic film to pull your seat back cover over the seat foam. I was going to use it on the Chevy bench seat, but Dan told me to give it a try without it first, and I didn't need it. The way I did my seat back was to turn the cover inside out, steam the corners, line up the top of the cover on the seat foam, then start pulling the cover down over the foam, turning it right side out as you go. (Does that make sense?) Remember that I was using vinyl and cloth with no sew foam sewn onto the back of it. I know that foam against foam doesn't slide much at all, but the fabric backing on the sew foam should help.
Welcome back Alan, and good luck on your seats!
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Scientists know that Alzheimer's disease begins to take root decades before its initial symptoms appear. One of the great challenges for researchers is to pinpoint the earliest signs of Alzheimer's before it can start to devastate a person's brain structure, memories, and reasoning. After years of collecting data, the NIA-supported Alzheimer's Disease Neuroimaging Initiative (ADNI) is yielding promising results about the structural and biochemical changes in the brain and the genetic variations that mark the onset and progression of Alzheimer's disease.
Launched in October 2004, this landmark study and public-private partnership has gathered and analyzed thousands of brain scans, genetic profiles, and biomarkers in blood and cerebrospinal fluid (CSF) in an ongoing effort to find more sensitive and accurate methods to detect Alzheimer's disease at earlier stages and mark its progress. (Biomarkers are proteins and other substances in the body that can be used to measure the progress of disease or the effects of treatment.)
"We're trying to understand this disease at earlier and earlier stages so that we can provide patients with a therapy that will slow or halt the disease process," says Dr. Neil Buckholtz, chief of the Dementias of Aging Branch in the NIA's Division of Neuroscience [1]. Although such a therapy may be years away, ADNI is working now to standardize the procedures and measures that scientists will use as they search for and test treatments that target the underlying disease.
The original goal of ADNI was to define biomarkers for use in clinical trials, specifically to determine the best way to measure treatment effects in Alzheimer's disease, says Principal Investigator Dr. Michael W. Weiner. "However, as the field has evolved, the goal has now extended to the use of biomarkers to detect Alzheimer's at a pre-dementia stage." Dr. Weiner directs the Center for Imaging of Neurodegenerative Diseases at the Veterans Affairs Medical Center in San Francisco and is a professor at the University of California, San Francisco.
Preliminary data from ADNI are yielding some exciting results. For example, Weiner and colleagues found that structural magnetic resonance imaging (MRI), [2] a technique that can determine, noninvasively, the detailed three-dimensional anatomy of the brain, has "huge potential" as a way to identify brain changes that are associated with Alzheimer's disease onset and progression. Another promising outcome is the development of a possible cerebrospinal fluid biomarker profile [3] (pattern of biomarkers) for the onset of mild Alzheimer's disease. ADNI researchers are also examining variations in genetic profiles that may be related to Alzheimer's risk.
Much recent work has focused on developing reliable ways to identify people with mild cognitive impairment (MCI) who will progress to Alzheimer's disease, so that we can determine the kinds of disease changes that warrant further investigation. People with MCI often progress to Alzheimer's—but they sometimes revert to normal cognition.
An assessment of multiple measures helps to identify Alzheimer's disease. These may include, for example:
The challenge for clinicians and researchers is to determine the specific combination of images and biomarkers that best predicts the development and progression of MCI and Alzheimer's disease.
ADNI Study Cores and Substudies
ADNI involves dozens of scientists at 59 study sites—54 in the United States and 5 in Canada—and is organized around eight core and two substudy areas (see box). The 821 ADNI participants include about 200 older adults with Alzheimer's, some 400 individuals with MCI, and about 200 cognitively normal people. Scientists have followed the participants with Alzheimer's disease through visits every 6 months for 2 years and have followed the other participants for 3 years.
Some of the leading-edge technologies under study are brain-imaging techniques, such as positron emission tomography (PET), including FDG-PET (which measures glucose metabolism in the brain); PET using a radioactive compound (PiB) that measures brain beta-amyloid; and structural MRI. Brain scans are showing scientists how the brain's structure and function change as Alzheimer's disease starts and progresses.
Biomarkers in cerebrospinal fluid are revealing other changes that could identify which patients with MCI will develop Alzheimer's. Scientists are looking at levels of beta-amyloid and tau in cerebrospinal fluid. (Abnormal amounts of the amyloid and tau proteins in the brain are hallmarks of Alzheimer's disease.)
According to Dr. Buckholtz, the idea is to correlate the cognitive assessments and other methods currently used to diagnose and follow the disease with precise brain scan results, measurements of fluid biomarkers, and genetic analyses. This would relate the results of these tests to the symptoms a person may be having. Current evaluation methods alone cannot tell doctors and researchers whether a beneficial cognitive effect in an individual with Alzheimer's or MCI results from the drug having a purely symptomatic benefit or whether it is actually slowing the progression of the disease, he says. It's hard to say without additional data. ADNI is designed to help researchers overcome that limitation.
"In medicine, there is almost never one best way," Dr. Weiner says. "I think that as we learn more about Alzheimer's disease biomarkers, different methods will be useful for different purposes."
Dozens of early studies based on ADNI data have already been published, with many more to come as further data are collected and analyzed. These early findings have generated excitement among researchers. For example, a structural MRI study of 449 participants by Weiner and colleagues found that people with Alzheimer's and MCI lost more volume in the hippocampus more quickly than did cognitively normal people, as shown by results of MRI scans at 6 and 12 months after obtaining baseline data. (The hippocampus, which plays a major role in learning and memory, is one of the first areas of the brain affected by Alzheimer's. disease.)
These losses were associated with deteriorating scores on cognitive assessments. In people with Alzheimer's, higher rates of loss in hippocampal volume also correlated with the presence of the apolipoprotein E (ApoE) ε4 gene, a risk factor for Alzheimer's. In people with MCI, higher rates of hippocampal loss were associated with lower levels of the peptide amyloid-beta 1-42 (Aβ1-42) in the cerebrospinal fluid.
"The finding of accelerating hippocampal loss is important for understanding the natural history of the disease and emphasizes the need for early diagnosis and therapeutic intervention," the researchers write.
Other ADNI studies, including one published by Jack and colleagues [4], have shown that PET imaging holds potential for a different use: the identification of people with Alzheimer's pathology who have not yet developed dementia. Weiner notes, "Detection of brain beta-amyloid can be used as a risk factor to predict future decline to Alzheimer's disease."
In another recently published ADNI study [3] by Dr. Leslie Shaw and colleagues at the University of Pennsylvania Medical School, cerebrospinal fluid samples from 410 volunteers showed lower levels of beta-amyloid, especially the insoluble type Aβ1-42, and higher levels of tau in people with the disease than in people with MCI. Likewise, people with MCI had lower Aβ1-42 and higher tau levels than did cognitively normal controls. These findings confirm the results of previous smaller studies.
Of the 37 volunteers with MCI at the start of the study, 33 were diagnosed with probable Alzheimer's a year later, while the other 4 were not. Regardless of outcome, cerebrospinal fluid biomarkers correlated well with those changes. Biomarkers in individuals who progressed from MCI to Alzheimer's disease were similar to those of participants with Alzheimer's disease, while biomarkers for people who reverted to normal were similar to those of normal participants.
"We're very keen on the idea of testing the use of biomarkers for grouping study participants into those at highest risk of developing Alzheimer's disease and those at least risk," says Dr. Shaw. This stratification could help identify the best candidates for future clinical trials, he explains.
Another major ADNI contribution to the field has been the creation of a publicly accessible database [5]. As it moves into the third year of data collection, the database contains more than 3,200 MRI scans, about 1,600 FDG-PET scans, about 960 cerebrospinal fluid measurements, genetic information, and other information, all maintained by the Laboratory of Neuro Imaging (LONI) at UCLA.
"One of the successes of ADNI is that these data are freely available," Buckholtz says. "The data are posted in real time. Any qualified researcher can request a password to access the data." So far, thousands of researchers worldwide have accessed the data.
Pharmaceutical companies also are starting to incorporate ADNI techniques into their trials, says Holly Soares, director of translational medicine at Pfizer Global Research and Development in Groton, CT, and chair of the ADNI industry scientific advisory board, which represents ADNI's private partners.
The value of the ADNI results lies in their utility for clinical trials of new drugs. Biomarker-based clinical trials will broaden the types of trials that drug makers conduct, Soares says. Some companies are beginning to plan for prevention studies, and having biomarkers that reliably predict who will progress to Alzheimer's disease will help researchers identify ideal study participants.
This ability to identify the best candidates for drug trials is perhaps ADNI's greatest contribution to clinical-trial design, Soares adds. Biomarkers will help pinpoint people in the early stages of disease, define differences in the way the disease progresses, and reduce the number of participants needed to gain statistically powerful results. Smaller samples mean lower costs, too.
A more targeted study population makes it easier to show whether new treatments work, says Dr. Russell Katz, director of the U.S. Food and Drug Administration's Division of Neurology Products: "You can better focus your study on participants who are more likely to respond to your drug."
"Eventually," Dr. Katz says, "we want to be able to say that when we fix the marker, we are likely to be helping the patient." He adds, "The hope is that we'll be able to treat people earlier and earlier. ADNI is laying the groundwork to do that."
As scientists collect and analyze more data, conferences are in the works to help reach a consensus on ways to standardize ADNI methods for clinical trials, according to Dr. Weiner.
October 1, 2009, marks the start of the sixth and final year of ADNI under current funding. Investigators are hoping to obtain funding to continue the study for 5 more years. ADNI is currently supported by a $67 million public-private partnership. The Federal Government's $40 million comes from the NIA primarily and the National Institute of Biomedical Imaging and Bioengineering, both parts of the National Institutes of Health. ADNI was recently awarded a Grand Opportunities grant from NIH as part of the American Recovery and Reinvestment Act.
As a major aspect of this study, the researchers will add people with early-stage MCI to the study population, says Dr. Buckholtz. Dr. Shaw adds that investigators would like to continue to analyze the thousands of cerebrospinal fluid and plasma samples collected, testing the performance of amyloid and tau to predict conversion from MCI to Alzheimer's, and looking to other biomarkers to refine the biomarker profile for Alzheimer's.
Jack, C.R., et al. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain. 2009. 132(5):1355-65.
Schuff, N., et al. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain. 2009. 132(4):1067-77.
Shaw, L.M., et al. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects. Ann Neurol. 2009. 65:403-13.


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Well Poacher and I have been doing a bit of cross training since the waterfowl has been a bit slow. This is the third weekend chasing Chucker but the first i've had my camera with me.
We only got 2 birds between 3 of us but the pup had a ball, don't know why but he seems to like to like chucker hunting as much as he likes ducks and geee.


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Fantasy Baseball Morning Update: Kemp, Tulowitzki injured
The Rangers allowed 21 runs last night. To the Mariners. That's like giving up 100 against a real lineup, right?
Dillon Gee's solid effort raised our streaming starter record to 36-22 for the season. We're going to take today off, as the three-game schedule includes five good, widely owned starters along with the terrible Jeremy Guthrie. Friday's selection is Felipe Paulino (owned in 10.3 percent of FOXSports.com leagues) against the A's.
On to the news:
- Dodgers OF Matt Kemp left last night's game after re-injuring his left hamstring, and will have an MRI today. A trip to the DL is a near-certainty, and Kemp thinks he'll miss a month. If you own Kemp, get your replacement immediately. The red-hot Dexter Fowler is owned in just 40.5 percent of FOXSports.com leagues, while further down the totem pole are Alex Rios (15.7 percent owned) and Colby Rasmus (4.8 percent owned). There are also plenty of speed demon types widely available, if that interests you. Rajai Davis (2.1 percent owned) has an everyday job, at least for a little while.
- Rockies SS Troy Tulowitzki suffered a strained groin during last night's game, and might be headed for the DL. We should know more today. Check out Elliot Johnson's (2.5 percent owned) numbers if you need a Tulo replacement, especially in deeper leagues.
- Dustin Pedroia's strategy to avoid the DL includes waiting for the swelling in his thumb to go down before trying to hit with a protective brace. He might still be disabled, but we probably won't know for a couple of days.
- Tigers SP Doug Fister is headed back to the DL with a strained left side.
- Blue Jays SP Brandon Morrow took a nasty line drive off his right shin last night (video here), but X-rays were negative and he's listed as day-to-day. Morrow's next start is scheduled for Wednesday, so we'll need to wait and see on his availability.
- The Indians have pushed Ubaldo Jimenez's next start from Saturday to Tuesday. They should have pushed it to December or January so we wouldn't have to see him again this season. Have I mentioned how horrible he is?
- Braves 1B Freddie Freeman finally got his new goggles yesterday. His first day of adjusting to them produced three hits with a homer, along with three RBI and two runs scored. I need to get a pair of those things to help my peripheral blogging vision.
- Back to Dexter Fowler: I expected a nice season from him, but not with all the production in one week. After last night's game, Fowler is 10-for-15 with three home runs, seven RBI and eight runs scored over his last four games.
- Diamondbacks closer J.J. Putz was unavailable last night due to a stiff neck, which is why David Hernandez got a four-out save. Don't read anything else into this.
- The Braves are making a change at shortstop, replacing rookie Tyler Pastornicky with prospect/gloveman Andrelton Simmons. The 22-year-old Simmons was batting .292 with three homers, 10 stolen bases and a .794 OPS before his promotion, but this is a big jump for him, so don't expect much offense other than maybe a steal per week. He's apparently amazing to watch in the field, though.
- This article suggests that Cubs 1B prospect Anthony Rizzo will get called up in late June. Unless they plan to DH Reed Johnson or Tony Campana against the Twins at Target Field from June 8-10, I still think we might see Rizzo then.
- Check out this story about Aroldis Chapman's Pittsburgh hotel room getting robbed on Tuesday. I don't know the details, but is trouble starting to follow this guy around? If he continues to strike out everyone, do you care?
- Listen to me, and listen good: Francisco Liriano's six shutout innings and nine strikeouts against the A's on Wednesday were just another part of his devious plot to suck you into his neverending web of fantasy disappointment. Just. Say. No.
- Do the Mets have any healthy shortstops left? Maybe, but none that you should pick up.
- Yoenis Cespedes' anticipated Friday return is a bigger deal for the A's than the upcoming decision on Manny Ramirez, who went oh-for-four with three whiffs in his Triple-A game on Wednesday. There's no word on when Ramirez will get the call.
- Look at A.J. Burnett's game-by-game stats when you get a chance. Other than a 12-run stinkbomb against the Cardinals on May 2, he hasn't allowed more than two runs in a game, and he's inducing boatloads of ground balls. I think Burnett is worthy of standard mixed-league rosters (if you can't stream him, anyway). He's owned in 8.5 percent of FOXSports.com leagues.
- Tim Lincecum gave up one run in seven innings last night, but the five walks mean there's still a dark cloud surrounding that silver lining. It wasn't a "He's back!" kind of start.
- Cardinals 2B Skip Schumaker (hamstring) appears headed to the DL. The Cards and Brewers are having quite the injury competition in the NL Central.
- There's a chance that the Nationals will activate Michael Morse in time for Friday's game. Check here tomorrow for an update.
- Indians DH Travis Hafner will miss 4-6 weeks with a knee injury. The Tribe will use a mishmash of DHs in Hafner's absence.
See you back here tomorrow morning.
Check out more Fantasy Baseball News and Notes.
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Would you like to save as your currency permanently or for this visit only?
Hotel Dubrovnik
Top Business Hotel
Gajeva 1, Zagreb
0.0 km from
Rp 1,026,667+
Exelent location,very good rooms, Parking for car is not near by.
Nice rooms in good repair. Air conditioning only cooled to 23 C. I asked reception 3 times to come to the room and check it out. I was largely ignored and the young guy on duty I asked for help went off duty late that night. Finally at 10:30 pm someone came, showed me how to set the thermostat, which I had allready done, and set the temp at 17 C. Did no good. The room temperature remained at 23 to 24 degrees all day and night. Nice hotel, excellent location, nice rooms, and very poor staff.
The hotel is OK, but KAYAK service is terrible, I sent you several e mails that I need invoice from you for my staying in hotel Dubrovnik, becouse I paid to you, not to hotel. Without invoice, I can't refund monay from the company where I work. I now understood that Kayak is not correct with their customers, you don't care about them.. Regards Davor Kostelic
Perfectly located in the very center of the city, it has complete facilities for everything needed.... and the price was very good!
hotel dubronki was centrally located but not noisy--the staff was effecient and pleasant..the rooms were nicely furnished--we stayed in a standard and there was a desk,,small table and chairs and two twin beds--traveling with adult child...the bathrooms were spacious and clean--there was no coffee in the rooms but otherwise everything you wanted was there--i would definitely recommend this hotel for anyone wanting to explore zagreb old town--we loved it.... the breakfast that comes with the room is very nice with large selection of meats/cheeses/grilled veggies/stuckli/ breads etc etc we ate breakfast here four times and was never disappointed...yum only thing was no coffee in rooms--but we did not find this in any room in croatia except one that came with a kitchenette and then that was instant--even thoough croatia has a coffee culture it is cafe oriented.
Excellent location - best in the city, good breakfast, the size of the hotel guarantees a lot of privacy In the end I was chared a price bigger than the one guaranteed on this site.
Hotel is situated exactly in the centre of Zagreb. Very clean and well furnished. Price reasonable. Personnel very friendly (very good English). Breakfast-very good choice of self-service bar.
Best location in the city for a hotel Nice large rooms Helpful staff Bathroom could have been cleaner
Excellent location for everything except arriving by personal car.
The location of the hotel is excellent and some of the rroms is refurbished
Good breakfast and location I had to pay 20€ per night for my dog. Small room.
location, every day cleanliness, breakfast noisy at night in the street, cold inside as window isolation is not good
The location was perfect, just below the old town. The staff were pleasant and helpful and we were given a small suite, although we only booked a double room. Excellent value. The guide book recommended the hotel restaurant, but unfortunately this has now closed.
The location is superb and the staff (almost all of them) extremely helpful! The facilities are a bit worn, but if you don't expect luxury it's ok. And the location makes up for any defects!
Very warm and attencious staff Nothing in the mini-bar; old beds.
It would be hard to be more central Zagreb than that... and the staff, in our case anyway, were not simply staff, they became friends.
The place where the hotel is great Everything was fine.
The staff is very friendly and helpful, they are really very nice people. The hotel is in the center of Zagreb.
If I am correct the hotel is the oldest hotel of Zagreb. The hotel is clean and the people are friendly but for me it was not what I expected as I was looking more for a business hotel. The hotel did not have an elevator, the parking is 5 minutes walking and you cannot get to the hotel with your car as the street is a walking street. Also the hotel is hard to find as it is located in a old shopping mall. Personally I would advice this hotel to tourists who want to be in the centre of the city without having to pay a high cost.
the breakfast saloon is decorated very nice; breakfast meal was good and various the hotel is situated on a pedestrian street / no auto access; a little bit of distance for carrying the luggage from the parking
Good location if travelling without car Room had unpleasant smell coming from bathroom and flooring was noisy. No possibility to alter heating of room - sometimes it was cold. Possibly due to cold weather outside dining-room was wintery as well.
Close to the sights we wanted to see. Nice and helpful staff.