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Reaching SMBs Through SMB Communities
Posted by Tim Harmon on July 30, 2010
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It's a well-established fact that social media is every bit as – if not more – influential for business decision-makers (B2B) as it is for consumers (B2C); Forrester clients can read more here. And SMBs are the most prolific of all business-size segments in utilizing social media and online communities to inform their technology purchase decisions. So where are SMBs turning to for that information? Where can you check the pulse of SMBs' thinking?
Using a couple of free Web tools, you can derive the relative popularity, if not the absolute Web site traffic volume, of various SMB-oriented online communities. Although their methodologies (and their numbers!) differ, Compete and Quantcast turn up the same results in terms of relative traffic volume. Here we use an average of the two, which indicates that, while community sites like Deluxe Corporations's PartnerUp, Sprint's and Microsoft's Business on Main, StartupNation, OfficeArrow, and YoungEntrepreneur.com are important sites for monitoring and participating in technology and business discussions, American Express' Open Forum is the granddaddy of them all:
Moreover, many of these communities have technology-specific discussion forums (e.g., Open Forum, PartnerUp, Small Business Brief).
There is debate, though, as to whether SMBs think of themselves in terms of an SMB or in terms of their vertical industry. The correct answer, of course, is both. As it applies to technology, SMBs will often identify with the SMB priority attributes of low cost, anti-complexity, and ease of sourcing. When it comes to functionality, they add their vertical industry relevancy into the decision process mix. So vertical communities need to be factored into the SMB marketing strategy as well:
These are representative examples. Let me know if you have other SMB-oriented online communities of interest that are bearing lead or insight fruit.
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by Fred Koch
Timeless tunes entertain the whole family
Too often we are lead to believe that "new is better." Sometimes it is true, but often times, at least in music, the reason so much great music has survived the test of time is simply because it is timeless. Generation after generation discovers the innate beauty and deep emotional feeling found in these classic songs and music. In this month's column, we will take a walk down memory lane as we revisit songs from classic movies and shows interpreted by Harry Connick Jr., sample some of Sir James Galway's favorite classical pieces for flute and hear about the music being performed by The von Trapp Children.
SONGS I HEARD, by Harry Connick Jr., Sony Records, $18.98, all ages; www.columbiarecords.com. "It's a fun record, but it's definitely for adults. I take these songs seriously," says Connick about "Songs I Heard," an ambitious effort on works from classic movies and shows. So does that mean that children might not enjoy this, too? I happen to believe that it is important for children to hear high-quality music, no matter what the genre. So, if Connick feels that this "adult-only" music is not appropriate for children, I think he's missing the point, as well as ignoring a potential fan base. If you are a Harry Connick Jr. fan, you will certainly look forward to playing this for your children.
The album is at times endearing, as when the familiar melody of the "Mary Poppins" classic "Supercalifragilisticexpialidocious" is infused with the energy of a Mardi Gras street band, and at times poignant, as on the "Annie" ballad "Maybe." Yes, the orchestrations and big band arrangements are musically complex and sometimes go on a little long, but I'm convinced that given the opportunity, children can relate to music on levels that might astound us.
I guess what impresses me most is that Connick not only is the marquee name and singer of all the material on "Songs I Heard," but he also arranged and orchestrated the music and conducted the musicians. The musical arrangements vary from lush and beautiful to quick and musically challenging, even for the most seasoned big band musicians. You will hear very tasty arrangements of "The Lonely Goathead," "Do-Re-Mi" and "Edelweiss" (The Sound of Music), "Ding-Dong! The Witch Is Dead," "Merry Old Land of Oz," "Somewhere Over the Rainbow" (Wizard of Oz) and "Jitterbug" (originally from Wizard of Oz, but omitted from the movie). Other highlights include a nice medley of "Pure Imagination" and "Candy Man," the upbeat "You're Never Fully Dressed Without A Smile" and one of my all-time favorite Disney songs, "Stay Awake" (Mary Poppins).
So if you enjoy the musical style of Harry Connick Jr., or are a big-band enthusiast or a movie music fan, you are sure to enjoy "Songs I Heard" and your children may pick up on your enthusiasm, too.
MUSIC FOR MY LITTLE FRIENDS, by James Galway, Sony Records, $17.98, ages 6-up; www.rcaredseal-rcavictor.com. Sir James Galway, one of the world's finest musicians, certainly understands the powerful effect that music has on children. Galway states, "Throughout my career, I have met, taught and played with thousands of children. Nothing gives me greater joy than being able to touch someone through music." On "Music For My Little Friends," Galway presents some of the most popular, as well as educational, works in the flute repertoire. His hope is that the music will be an inspiration to the young, budding flutist. Sure, the excerpts presented on this recording might serve as a concise collection of beautiful flute music available to the aspiring musician, but it also works as a wonderful introduction to classical music for the ears of young listeners and adults.
Galway is in superb form as he glides effortlessly from Mozart's "Rondo alla Turca" and Saint-Saéns' "The Swan" (The Carnival of the Animals) to Gabriel Fauré's "Pavanne" and "Sicilienne" to Maurice Ravel's "Pièce en forme de habeñera" and even the traditional "Danny Boy."
This 2002 Parents' Choice Recommended CD travels the emotional spectrum from sweet and carefree to playful and pensive. Galway, accompanied by the London Mozart Players and pianist Phillip Moll, has masterfully selected a set of flute-friendly pieces that is sure to please lovers of classical music.
THE VON TRAPP CHILDREN, VOL. 1, by The von Trapp Children, Rattlesby Records, $16, ages 6-up; www.vontrappchildren.com. If the name sounds familiar, you are right. These von Trapp children are the great-grandchildren of Captain von Trapp, father of the famous singing family that inspired the film "The Sound of Music." Now, the von Trapp family has returned to the spotlight with the release of their first CD. Singing an extensive repertoire of music including folk, classical and classic pieces from "The Sound of Music," the children, who range in age from 7 to 14, are becoming known in their own right for their effervescent voices and lovely harmonies. They have been performing live for the last five years, having made numerous television appearances and opening for such acts as George Winston and Peter, Paul and Mary.
The children's four-part harmony is showcased in 17 songs on the album, ranging from classical and traditional folk and sacred to contemporary pop tunes. Titles include "Edelweiss," "Amazing Grace," "Scarborough Fair," "Homeward Bound," "Blue Cheese" (an old camp favorite) and various traditional Austrian songs. Other hightlights include "Wayfaring Stranger," "Dona Nobis," "Children's Prayer" (from Hansel & Gretel), "All The Pretty Little Horses" and, probably my favorite, "Father's Eyes." The family especially likes to perform at benefits, such as the one earlier this year at Ground Zero that aided firefighter and police families. That led to a rebooking at a New York City firefighters picnic on Labor Day. By helping to raise money for others, the children are following in the footsteps of the original family, who collected blankets and other relief supplies during their concerts after the war and sent the items to refugees in Europe. The children's parents, Annie and Stefan, realize that the legacy is important and that their children are connected to something very special. "They've always loved singing, and we feel God has given them this special gift," Stefan said. "If we can give this gift to people and represent the family, we'll let them sing."
Here's hoping they find success, continue to sing and start to work on Volume 2.
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Recruitment of the cohort of families with hereditary deficiencies of protein S, protein C, or antithrombin.
Event-free survival in protein S–, protein C–, and antithrombin-deficient and nondeficient female relatives who ever or never used combined oral contraceptives and in deficient male relatives. The sample sizes represent women at risk. Group 1 indicates deficient men; 2, deficient ever users; 3, deficient never users; 4, nondeficient never users; and 5, nondeficient ever users.
van Vlijmen EFW, Brouwer JP, Veeger NJGM, Eskes TKAB, de Graeff PA, van der Meer J. Oral Contraceptives and the Absolute Risk of Venous Thromboembolism in Women With Single or Multiple Thrombophilic DefectsResults From a Retrospective Family Cohort Study. Arch Intern Med. 2007;167(3):282-289. doi:10.1001/archinte.167.3.282
© 2017
The risk of venous thromboembolism (VTE) in women taking combined oral contraceptives (COCs) is attributed to changes in coagulation and fibrinolysis. Their impact may be greater in women with preexistent thrombophilic defects.
We assessed the effects of COCs on absolute VTE risk in women with single or multiple thrombophilic defects in a retrospective family cohort study. Female relatives of probands with VTE and hereditary deficiencies of protein S, protein C, or antithrombin were tested for known thrombophilic defects, including the index deficiency. Absolute incidences of VTE were compared in deficient vs nondeficient women, in deficient and nondeficient women who ever or never used COCs, and in deficient and nondeficient women with 0, 1, or more than 1 other thrombophilic defect during exposure to COCs.
Of 222 women, 135 (61%) ever used COCs. Overall, annual incidences of VTE were 1.64% and 0.18% in deficient and nondeficient women, respectively; the adjusted relative risk was 11.9 (95% confidence interval, 3.9-36.2). The risk was comparable in deficient ever and never users (1.73% vs 1.54%). Annual incidences during actual COC use were 4.62% in deficient women and 0.48% in nondeficient women; the relative risk was 9.7 (95% confidence interval, 3.0-42.4). The incidence increased by concomitant thrombophilic defects, from 3.49% to 12.00% in deficient women and from 0% to 3.13% in nondeficient women.
Women with hereditary deficiencies of protein S, protein C, or antithrombin are at high risk of VTE during use of COCs, particularly when other thrombophilic defects are present. They have VTE at a younger age, but the overall risk is not increased by COCs.
Since their introduction in 1960, combined oral contraceptives (COCs), containing a combination of ethinyl estradiol and a progestagen, are associated with an increased risk of venous thromboembolism (VTE).1,2 Despite an up to 10-fold reduction in the dose of both components, this risk, albeit lower, has persisted.3 Up to 1995, the risk of VTE was attributed to ethinyl estradiol, because this component is identical in all COCs, while the type of progestagen included may differ. It is the opinion that the type of progestagen may also influence the VTE risk, because the use of third-generation COCs (containing desogestrel or gestodene) in healthy women was reported to result in a higher risk than the use of second-generation COCs (containing levonorgestrel).4- 6 Nevertheless, because of the low baseline risk of VTE in healthy women of fertile age, ranging from 1 per 100 000 years at the age of 15 years to 10 per 100 000 years at the age of 44 years,7,8 the absolute risk of VTE in COC-using women is low (20-40 per 100 000 pill-years).4- 6
The biological background of this association is complex. Combined oral contraceptives induce changes in coagulation and fibrinolysis but, in healthy women, hemostatic variables remain within their normal ranges.9,10 It is likely that these changes may have more impact in women who are already at increased risk of VTE because of preexisting thrombophilic defects. Although several observational studies11- 17 reported on the interaction of COCs and various single thrombophilic defects, little is known about the absolute risk of VTE attributable to COCs in women with single or combined thrombophilic defects.16,17 Recently, aggregation of multiple thrombophilic defects in families with hereditary deficiencies of protein S, protein C, or antithrombin was demonstrated, and it was shown that the risk of VTE strongly depended on the presence of 1 or more other thrombophilic defects.18 In the present study, we analyzed the data from this large family cohort to assess the effects of COCs on the absolute risk of VTE in protein S–, protein C–, or antithrombin-deficient women and the contribution of other known thrombophilic defects.
The original retrospective study18 was performed in a cohort of protein S–, protein C–, and antithrombin-deficient families. Briefly, probands were consecutive patients with documented VTE, in whom 1 of these deficiencies was demonstrated. First-degree relatives older than 15 years were identified by pedigree analysis. Because the number of antithrombin-deficient probands was small, second-degree relatives with a parent who was deficient were also identified. Relatives were enrolled after informed consent was obtained. Information on previous episodes of VTE, exposure to exogenous risk factors for VTE, and anticoagulant treatment was collected by physicians at the thrombosis outpatient clinic of our hospital, using a validated questionnaire,19 and by reviewing medical records. In women, COC use and obstetric history were documented in detail. Blood samples were taken after collection of clinical data. All relatives were tested for additional thrombophilic defects, including a second deficiency of protein S, protein C, or antithrombin; factor V Leiden, or prothrombin G20210A; increased levels of factor VIII, IX, and XI; lupus anticoagulant; and hyperhomocysteinemia. In the present study, we analyzed female relatives of fertile age from the family cohort. Male relatives of comparable age were used as a reference group. The study was approved by the institutional review board of University Medical Center Groningen.
Venous thromboembolism was considered established when diagnosed by compression ultrasonography or venography (deep vein thrombosis) or by ventilation and perfusion lung scanning, spiral computed tomographic scanning, or pulmonary angiography (pulmonary embolism); or when the patient had received full-dose heparin and vitamin K antagonists for at least 3 months without objective testing when these techniques were not yet available. Venous thromboembolism was classified as secondary when occurring within 3 months after exposure to exogenous risk factors, including surgery, trauma, immobilization for 7 days or more, COC use, hormone therapy, pregnancy and puerperium, and malignancy. In the absence of these risk factors, VTE was defined as primary. Superficial phlebitis was not counted as a thrombotic event, because it was usually not confirmed by an objective technique and consequently might not be accurately classified in the setting of this retrospective study.
Protein S and protein C antigen levels were measured by enzyme-linked immunosorbent assay using reagents from DAKO, Glostrup, Denmark. The activity of protein C (Berichrom Protein C; Dade Behring, Marburg, Germany) and antithrombin (Coatest; Chromogenix, Mölndal, Sweden) was measured by chromogenic substrate assays. Levels of protein S, protein C, and antithrombin were expressed as percentages of the levels measured in pooled plasma set at 100%. Normal ranges were determined in 393 healthy blood donors without a (family) history of VTE, who were neither pregnant nor used COCs in the 3 months before blood sampling. Protein S deficiency type I was defined by total protein S levels below the lower limit of its normal range (<67%), and protein S deficiency type III by lowered free protein S levels (<65%), but normal total protein S levels. After we had demonstrated that protein S deficiency type III was not a risk factor for thrombosis in these families, we excluded families with this deficiency from the analysis.20 Protein C deficiency types I and II were defined by lowered levels of either protein C antigen (<63%) or activity (<64%), and antithrombin deficiency by lowered levels of antithrombin activity (<74%). Deficiencies were considered inherited when confirmed by measurement of a second sample collected after a 3-month interval and demonstrated in at least 2 family members. Factor V Leiden and prothrombin G20210A were demonstrated by polymerase chain reactions.21,22 Factors VIII:C, IX:C, and XI:C were measured by 1-stage clotting assays (Amelung, Lemgo, Germany) and considered increased at levels greater than 150%. Lupus anticoagulant was demonstrated by abnormal dilute Russell viper venom time and activated partial thromboplastin time or tissue thromboplastin inhibition, normalized by adding phospholipids.23 Fasting and post–methionine-loading levels of homocysteine were measured by high-performance liquid chromatography.24 Hyperhomocysteinemia was defined as a fasting homocysteine level greater than 2.50 mg/L (>18.5 μmol/L) and/or a postloading level greater than 7.95 mg/L (>58.8 μmol/L), as described in the Dutch population.25 In probands and symptomatic relatives, blood samples were collected at least 3 months after VTE had occurred. If they were then still treated with a short-acting vitamin K antagonist (acenocoumarol), samples were taken after temporary change of this therapy into subcutaneous nadroparin treatment for at least 2 weeks.
We compared the absolute risk of a first episode of VTE in deficient and nondeficient female relatives, who were divided into women who ever or never used COCs during their fertile lifetime. Probands were excluded from analysis to avoid bias. Annual incidences were calculated by dividing the number of first episodes of VTE by the number of person-years. Person-years were counted from the age of 15 years until the age of 50 years, the first episode of VTE, or the end of the study period. A minimum age of 15 years was chosen because VTE is rare at a younger age, and a maximum age of 50 years was chosen as the end of a fertile lifetime. Event-free survival was analyzed by the Kaplan-Meier method. In this analysis, male-deficient relatives were used as a reference group.
In addition to the overall risk of VTE during fertile lifetime in ever and never users, we calculated the risk of VTE related to actual COC exposure in deficient and nondeficient women. In this calculation, person-years was defined as the number of pill-years, including a 3-month exposure window after COC use was discontinued.
Moreover, we estimated the contribution of concomitant thrombophilic defects in deficient and nondeficient actual COC users. Concomitance was classified as no other thrombophilic defect, 1 other thrombophilic defect, and more than 1 other thrombophilic defect.
Crude relative risks (RRs) were based on annual incidences, and 95% confidence intervals (CIs) were calculated using the binomial probability model (conditional small sample approach).26 To account for clustering of women within families, outcome rates were analyzed by random-effects logistic regression with gaussian distribution, resulting in adjusted RRs and 95% CIs.
Continuous variables were expressed as mean values and standard deviation or median values and range, and categorical data as counts and percentages. Differences between groups were evaluated by the t test or the Mann-Whitney test, depending on the normality of data, for continuous data and by the Fisher exact test for categorical data. A 2-sided P<.05 indicated statistical significance.
Analyses were performed using SAS statistical software, version 8.2 (SAS Institute Inc, Cary, NC), and Stata software, version 9.1 (Stata Corp, College Station, Tex).
The original family cohort contained 91 unrelated families from 39 protein S–deficient probands, 40 protein C–deficient probands, and 12 antithrombin-deficient probands, including 263, 277, and 185 relatives, respectively (Figure 1). Seven families (19 relatives) were excluded because inheritance of the deficiency in the probands could not be established by testing their relatives. The mean (SD) age at the time of VTE was 29 (11) years in the 49 female probands and 38 (14) years in the 35 male probands. Of the female probands, 43 (88%) had secondary VTE (14 because of COC use, 6 because of pregnancy, 16 because of puerperium, and 7 because of trauma, surgery, or immobilization), compared with 8 (23%) of male probands (because of trauma, surgery, or immobilization). Overall, 343 relatives were female, of whom 121 could not be enrolled because of prior death (n = 50), being 15 years or younger (n = 59), no consent (n = 9), or geographic distance (n = 3). Death was possibly related to VTE in 5 women, of whom 2 died at a fertile age. The response rate of eligible women was 95%. The remaining 222 women were analyzed. Their characteristics are summarized in Table 1. One hundred one (45%) of these women were deficient. Fifty-six deficient and 79 nondeficient women had ever used COCs. The mean age at the start of COC use was 22 years. Most women (78%) had only 1 period of COC use. The median duration of COC use was 5 years (range, 0.03-27 years). Thirty-four events were reported, of which 31 (91%) were classified as secondary; 16 events were related to COC use, and 11 to pregnancy or puerperium.
Overall, the annual incidence of VTE was 1.64% vs 0.18% in deficient vs nondeficient women; the adjusted RR was 11.9 (Table 2). The highest risk of VTE was observed in antithrombin-deficient women (2.06%), compared with 1.89% in protein C–deficient women and 1.01% in protein S–deficient women. Antithrombin nondeficient women had the lowest risk (0%); the risk was 0.17% and 0.31% in protein C and protein S nondeficient women, respectively.
The annual incidences were 1.73% vs 0.16% in deficient vs nondeficient ever users of COCs, and 1.54% vs 0.21% in deficient vs nondeficient never users. There was no significant difference between deficient ever and never users (adjusted RR, 1.3; 95% CI, 0.5-3.8). Fifty-five percent of ever users and 58% of never users experienced 1 or more pregnancies. In deficient ever users, 80% of VTE episodes were related to use of COCs, whereas in deficient never users, 67% were related to pregnancy. Event-free survival analysis showed that there were no differences between deficient ever users, deficient never users, and deficient men at the age of 50 years. First events occurred earlier in deficient ever users and, although less pronounced, in deficient never users than in deficient men (Figure 2).
The annual incidence of VTE during actual COC use was 4.62% in deficient COC users, compared with 0.48% in nondeficient COC users (Table 2). The annual incidences were 2.42%, 7.06%, and 5.14% in protein S–, protein C–, and antithrombin-deficient women, respectively, compared with 1.01%, 0.29%, and 0% in nondeficient COC users, respectively (Table 2).
Details of the 16 women who experienced a first episode of VTE while using COCs are presented in Table 3. Thirteen women (81%) were protein S, protein C, or antithrombin deficient. Concomitance of 1 or more other thrombophilic defects was demonstrated in 10 (77%) of the 13 deficient women, and in all 3 nondeficient women. Thirteen women (81%) were first-ever users of COCs. The mean age at onset of VTE was 24 years. Of the women, 69% experienced their first event within 6 months of the start of COC use.
Exposure to third-generation COCs was associated with a higher risk of VTE than exposure to second-generation COCs. Overall, annual incidences were 5.43% vs 1.19%; the RR was 4.5 (95% CI, 1.4-15.7). In deficient women, these were 6.85% and 4.35%, respectively (RR, 1.6; 95% CI, 0.4-6.6); in nondeficient women, 3.57% and 0.31%, respectively (RR, 11.7; 95% CI, 0.9-344.4). However, risk estimates might not be accurate because of the inability to retrieve the brands used in 19 women.
Concomitance of other thrombophilic defects was demonstrated in 57% of deficient women and in 70% of nondeficient women (Table 1). Of these women, a second deficiency of protein S, protein C, or antithrombin, and lupus anticoagulant was not found. The remaining concomitant defects were equally distributed among deficient and nondeficient women. The annual incidences of VTE in deficient actual COC users with 0, 1, or more than 1 concomitant defects were 3.49%, 5.56%, and 12.00%, respectively, compared with 0%, 0.31%, and 3.13% in nondeficient actual COC users, respectively (Table 4).
This study shows a high absolute risk of VTE in protein S–, protein C–, and antithrombin-deficient women, compared with their nondeficient female relatives. Combined oral contraceptives hardly contributed to the overall risk during fertile lifetime. Cumulative event rates at the age of 50 years were similar in women, either ever or never users of COCs, and in men. However, event-free survival curves showed VTE to occur earlier in deficient ever users and, although less pronounced, in deficient never users than in deficient men. These differences between women and men are most likely because of COC use in deficient ever users and because of pregnancy in deficient never users. Therefore, COCs and pregnancy resulted in the occurrence of VTE in deficient women at a younger age, but did not increase the overall risk of VTE during fertile lifetime.
The absolute risk of VTE in deficient women during actual COC use was almost 10-fold higher than in nondeficient COC users (4.62% vs 0.48%). This risk is 115- to 230-fold higher than the published absolute risk in healthy women of fertile age during actual exposure to COCs (0.02%-0.04%).4- 6 The 12- to 24-fold higher risk in nondeficient COC users is explained by the presence of other thrombophilic defects (described later).
Several studies have evaluated the contribution of COC use to the risk of VTE in women with thrombophilic defects. Most studies were addressed to factor V Leiden or prothrombin G20210A, both more prevalent but milder risk factors for VTE than the previously mentioned deficiencies.11- 15 Only 2 studies16,17 reported on the absolute risk of VTE in protein S–, protein C–, and antithrombin-deficient women. The first, a retrospective case-control study,16 compared deficient females who used COCs with those who did not use COCs. The incidence of VTE was increased only in antithrombin-deficient COC users. A comparison with our results is hampered by differences in design because this study also included probands, who by definition had experienced VTE, and patients with prior VTE, whereas superficial phlebitis was counted as an event. The second, a family cohort study,17 reported incidences of 4.3% and 0.7% per year in deficient and nondeficient female relatives who used COCs, respectively, in line with our results.
We demonstrated 1 or more other thrombophilic defects in 57% of deficient and in 70% of nondeficient relatives. These prevalences were higher than is expected in the general population, particularly for factor V Leiden, prothrombin G20210A, increased factor VIII plasma levels, and hyperhomocysteinemia. Apparently, these defects aggregated in these families.
The risk of VTE in deficient women during COC use strongly increased in the presence of 1 or more other thrombophilic defects. The annual incidences of VTE increased from 3.49% (no defects) to 12.00% (>1 concomitant defect). In nondeficient women who used COCs, other thrombophilic disorders increased the risk from 0% (no defects) to 3.13% (>1 defect). The combination of a deficiency with more than 1 other thrombophilic defect exceeded the reported risk of VTE during COC use in healthy women up to 300- to 600-fold. This finding indicates a synergistic interaction of various thrombophilic defects and COC use. Two previous studies27,28 that evaluated the risk of multiple thrombophilic factors in carriers of factor V Leiden or prothrombin G20210A showed a similar effect.
Based on our results, we recommend that the use of COCs be strongly discouraged in women with inherited deficiencies of protein S, protein C, or antithrombin. Even in their nondeficient female relatives, this might be considered, unless they have negative test results for all known thrombophilic defects. Because 45% of female relatives were deficient and 70% of nondeficient women had 1 or more other thrombophilic defects, one might suggest not to use COCs to all female relatives of patients with deficiencies, without further testing. Despite an excessive risk of VTE during the use of COCs in women with deficiencies, the impact of this finding is limited because the prevalence of these deficiencies is low. However, it is likely that COCs will also increase the risk of VTE in women with other single or combined thrombophilic defects.27,28 Although the latter are milder risk factors, their contribution to the risk of VTE in the female population may be greater because they are more prevalent. We speculate that COC-related VTE observed in a small proportion of the female population might be attributed to a preexistent higher risk of VTE as a result of single or combined thrombophilic defects. If so, COCs can safely be prescribed to the remaining majority of women without these defects. We agree that it is neither feasible nor cost-effective to test all women before the use of COCs. In clinical practice, however, testing for hereditary deficiencies of protein S, protein C, and antithrombin should be considered in women with a family history of VTE, especially when VTE had occurred at a young age and was related to the use of COCs.29
This retrospective study has several limitations. The small sample size resulted in wide CIs and unstable estimates. Several events were not established by objective techniques, because these were not available yet. Several relatives were not tested for all concomitant thrombophilic defects, mainly because of insufficient amounts of plasma collected at enrollment. The concomitance of thrombophilic defects was classified by the number of defects, although the thrombotic potency of different defects may vary. However, subgroups of relatives with specific combinations were numerous and consequently too small to allow accurate estimates. We tested 1600 patients to obtain 91 probands, corresponding with a prevalence of hereditary deficiencies of 5.7%, in line with previous series30 of unselected patients with VTE. Therefore, referral bias seems unlikely. Selection bias was avoided by testing consecutive patients with VTE and an extraordinarily high response rate of relatives. Because only a few women died of VTE at a fertile age, the results of this study will not be influenced by an excess of fatal events in deficient relatives. Finally, the risk of VTE might have been overestimated by selecting symptomatic deficient patients, but asymptomatic deficient subjects and their relatives are not identified in clinical practice. Despite these limitations, to our knowledge, this is the first study to address the multicausality of VTE in COC-using women, including all known thrombophilic defects and deficiencies. Further studies are warranted to establish our findings.
In conclusion, the high risk of COC-related VTE in women with hereditary deficiencies of protein S, protein C, or antithrombin strongly depends on frequent concomitance of other thrombophilic defects. These women have VTE at a younger age, but COCs do not increase the overall absolute risk of VTE over fertile lifetime.
Correspondence: Jan van der Meer, MD, PhD, Division of Haemostasis, Thrombosis and Rheology, Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, the Netherlands (email@example.com).
Accepted for Publication: October 12, 2006.
Author Contributions:Study concept and design: van Vlijmen and van der Meer. Acquisition of data: van Vlijmen and Brouwer. Analysis and interpretation of data: van Vlijmen, Veeger, Eskes, de Graeff, and van der Meer. Drafting of the manuscript: van Vlijmen. Critical revision of the manuscript for important intellectual content: Brouwer, Veeger, Eskes, de Graeff, and van der Meer. Statistical analysis: Veeger. Administrative, technical, and material support: van Vlijmen, Brouwer, and van der Meer. Study supervision: van der Meer.
Financial Disclosure: None reported.


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Im sorry I posted here but no one ever looks in the wanted thread and i need the part in NY ASAP.
those with upgarded brakes maybe you want to part out your stock brakes.
I stripped the threads on the braket that holds the brakes.
I need that peace ASAP Its the drivesr side bracket that looks like a this L_____I. Brake pads go inside of it.. Im in NY. WILL PAY!!!!!!!!!


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Are you a ConvergeCFD user with EnSight?
Do you have a Single Dataset, but multiple time periods which you translated to Case Format? Ie you export results from Time T = 0 to T1 in one operation, then later exported from Time T2 to Time T3, and then again exported reults from Time T4 to T5?
If so, then currently you have multiple different time 'sets' or 'periods', which can't easily read into a single session of EnSight (other than using Multiple Cases, but that is not what Cases are meant for).
Would you then like to be able to operate on this solution as though it were one complete time period from T = 0 to T5? Well, I think we have a little tool for you. This tool should provide you back with a single coherent time period (From T = 0 to T = T5) as a single case.
This little python tool takes a look at all of the .case files in your current directory, and gathers up a list of all of the files that are referenced, constants written, and time values. In then creates a internal global list of all of that infomation, and sorts it in ascending time order. It then renames all of the associated files so that they fall into a single progression in time order, and generates a NEW case file, referencing the global total time, global total constants, and the newly renamed set of variable and geometry files. The routine takes only a second to run (renames are quick), and you should be able to load up the NEW case file into EnSight.
As renaming files is perhaps a dangerous thing, the routine also writes an "undo" file as well. You can run the "undo", and you will get back to your original set of files (if you need to for some reason).
As with any routine, there are some assumptions, limitations, and caveats. They shouldn't be too restrictive, but here they are, so you have a better idea about what the routine is expecting:
a. All of the case files are in the same directory (the routine doesn't go rooting around in sub directories looking for .case files to merge).
b. All the .case files in the current directory are meant to be "merged" into one. If there are some which aren't meant to be merged, just move them temporarily to somewhere else.
c. When you exported the results (using post_convert), you ALWAYS exported the same variables. No exceptions allowed, no if's, but's, no coconuts. (EnSight can't deal with some variables existing at some times, and not others…. rules are rules).
d. The time values can overlap, and be of varying delta T. The routine should handle that okay.
e. The routine assumes you have measured data (default for converge post_convert us).
f. Due to internal coding assumptions/methods, this routine is for CONVERGE users only. If you have results from OpenFOAM, or Fluent, CFx, or other solvers, please contact CEI (email@example.com) separately. We have some prototypes for other solvers.
To run the routine, simply download the python file, and place it into the directory you want to merge Converge .case files together. Then, type :
cpython31 merge_time_case.py
After running, should you need to undo, there will be a new python file created in your directory, and that can be run via:
cpython31 merge_time_UNDO.py
This works for MAC/Linux/Win. Use a cmd shell in Windows to run the python routine.
As always, please contact if you have questions, comments, requests. We'd love to hear from you, and work with you to provide you with the best post processing experience.
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Once downloaded, simply unzip the file to find the python .py routine.


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E63 / E64 6 Series (2004 - 2010)
The E63/E64 BMW 6 Series builds on BMW's sporty heritage with aggressive lines and an incredible motor to back the design up. Available in coupe and convertible trims with a standard 4.8 liter engine producing 360 horsepower and 360 lb-ft of torque, the 6-series is a popular choice that exceeds expectations.
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pre-purchase questions on a 645
Hello all - I'm new to the forum but not to BMWs (have had them since '97, when I graduated from driving exclusively VW Bugs...) Have since turned my husband on to them (he used to be a big truck guy) and now he's upgrading to a 6-series convertible. Done a fair amount of research on cars.com, autotrader, edmunds, and now the forums, where the real nitty gritty details are! Bimmerfest seems like one of the most active forums (at least for 6ers) - I've already learned a ton from the "what did you learn after you bought your 6" thread - very cool.
We've been shopping around, and found what seems to be a good deal on a 2005 645 convertible - less than $15k miles, under $40k, although a little stripped down on options (no seat heaters!!). Here are some questions I have before we pull the trigger - hope you guys can help!
- seller says it has "premium sound" - how can I tell? It has 6 speakers, but no 6-disc changer. If its the Logic 7 speaker where is the 7th speaker (or how many speakers are the)? I didn't see this in the downloadable owner's manual. Also, where would it be branded "Logic" (if anywhere)?
- The production date is October 2004 - so it is an early 2005. In your experience, will we still encounter electrical bugs, i.e. with the iDrive? Anything we should test for or have a mechanic check during our prepurchase inspection?
- We actually did take it to get inspected at a separate dealer; unfortunately they found a leaky transmission pan and a "noise" coming from the front, a "possible strut brace" or something. The seller (also a dealer, but independent) is fixing these problems and we'll have it re-inspected again by the non-selling dealer. However, would these issues on a 15k mile car worry you?
Edited to add that the seller-dealer is now "replacing the front arm bushings" - does that change anything? (can you tell I'm a researcher but not a mechanically-inclined person.... )
(possibly related, when we tried out another 2005 645, it had major creaking when turning tightly - not sure if this is strut related also, but might front-end noise/clunks/creaks be a common problem in 6s?)
Anything else we should know?
Thanks so much for your collective knowledge - looking forward to browsing around! This car is our first step out of the 3series and it seems to be a whole different animal!
Last edited by Beemie; 04-14-2010 at 03:13 PM.
I should add that regarding the sound system, I found this very useful thread here: http://www.bimmerfest.com/forums/pri...d.php?t=374584 but unsure if it also applied to 2005 645s... Thanks.
too expensive... for that price you can get an 06 if you look hard enough... I'd go with something around 30K miles as in a year or so warranty will be gone and miles won't matter. 06's are 650i vs 645 and just a bit different in power.. (nothing against our beloved 645 owners)...
also these are driving cars, so if they're not driven much, some of the problems may not have showed up until the warranty is gone... (warranty is worth a lot as these can be expensive to fix)... also there are some convertible unlocked problems that are just more common in the 645's...
the 7th speaker is on the dash behind the navigation.. it's a center speaker...
if you can find one with HUD... get it... until you'e driven with HUD you won't know what you're missing... I really don't even know how to read my gauge cluster as I'm so dependent on HUD...
either way good luck... others will chime in
07 650i Cabrio CPO, Titanium Silver
Black Matte Grill
Dark Birch Wood Interior and Shifter
HUD, Cold Weather and Sports Package
Logic 7 Sound
Aluminum Racing Pedals
K&N Air Filters
Rays Master Piece REM 20" Forged wheels w/ Conti Extreme DWS
You should get the build sheet and it will tell you what the vehicle has. The car that you're looking at doesn't have the premium sound system; if it did there would be a disc changer in the glove box. It also doesn't have the cold weather package. Also make sure that you have the sport package. The resale value on the six series is awful if it is a stripped example.
Do NOT buy one of these cars if there is anything wrong with it. You are looking at a lot of money to start fixing and chasing things. Also, do yourself a favor: get an expert pre purchase inspection, spend the money, it is well worth it.
I'd highly recommend purchasing a warranty for it as well... and make sure the one you are looking has full electronics coverage and a low per visit deductible. As others have stated, repairs (and maintenance) on these cars can be very spendy.
Mileage is one thing to worry about, but age of the car is also a big factor.
2004 645ci - SOLD
It seems you have been doing your home work on the 6. Good. Now try and get a detailed vehicle maintenace history. Pull the VIN and call any dealership and they can give you details over the phone or if there is a dealer close by, go there and see the folks in the service department. They will also let you know if that particular 6 came with the premium system because sometimes the previous owner might have removed the 6 disc changer to put in a ipod interface. you never know. Depending on who you deal with, they can be very helpful. You are doing the right thing by having the inspection done. You mentioned dealer but was it a BMW dealer doing the inspection? Also, look for any reoccurring maintenace issues. On some of the earlier models, some folks have issues with the convertible top sensors. The price to me seems a bit high if this car is the basic version. Get sport package, bigger wheels and better seats as well. Unless you are in a very warm area, the heated package is very nice to have.
2012 650-xDrive Convertible. Titanium Silver Metallic - M Package - Driver assist package- Cold weather package - luxury seating package - Bang & Oulfsen system.
Previous Cars:
2008 650 Convertible 6 speed manual
2004 645 Convertible 6 speed manual
1994 540 6 speed manual
Wow, thanks so much for your helpful responses! Good points re warranties and repairs (vs. just considering low miles). I wonder if a higher mileage car (30k miles) that had BMW's 6 year, 100k mile extended warranty would be wiser? We have seen a couple of those. It really seems owning a 6 is like owning a horse - the purchase price is by far the LEAST of the expenses you will incur.
The car we're looking at is at an indepdent dealer that sells a variety of luxury car makes. Presumably they do some dealer reconditioning, although the fact that the car had a leaky transmission pan and something wrong with the suspension makesme wonder how carefuly they check the cars before putting them on the lot.
The prepurchase we did was at an official BMW dealership down the road (Sterling BMW in Newport Beach) - they did their standard 31-point inspection and turned up those two issues. The independent dealer is fixing those problems using their preferred mechanic, so we are going to have Sterling BMW re-inspect today make sure the work was done.
You guys are right - no cold weather package; also no HUD, no wood trim (only the aluminum looking stuff). The premium sound question is still being debated. My husband said he DID find 11 speakers afterall (versus 8, I think, based on the info in the thread I linked to above). But there's no 6-disc changer (and no mp3 alternative there). It does have the sport package and chromed stock rims. In fact, it seems the main reason my husband likes this particular so much is the color combo of GRAY soft top (plus silver gray metallic paint), beige int., and the chromed rims. The starting price was $39,900 - dealer is willing to go down only to $38,500 - is that still high and should we push for lower? Of course, the dealer has just completed repairs like replacing the bushing arms (or something like that) and repairing the leaky pan - which I think they'd have done before placing the car on the sales floor...
I'm personally a little hesitant on this particular car based on all you've said and all of the above, but I also don't want to rain on my husband's parade since it's really going to be his car.
Thanks so much again for your thoughtful responses!
Last edited by Beemie; 04-15-2010 at 07:50 AM.
If the car doesn't have the sport package it is WAY TOO expensive. Also a 39 point inspection won't scratch the surface of all the items that need to be checked.
One of the few options it DOES have is the sport package (phew) - does that change thoughts on the $38,500 price?
chasz17 - this is good to know! An official BMW dealer is doing the prepurchase inspection we're for a re-inspection today - what else should we ask them to check aside from their standard 31-points?
car is way overpriced, for a maintnance extensive car, regardless of miles, with no warrenty or maintnance plan, i would go low blue book/trade in value, knowing the maintnace and issues are going to be comming out of the owners pocket. remeber this is a down economy and its a depreciating asset
i payed $29.5k for my fully loaded 2006 650, with 60,000 miles on it, with CPO and maintnance plan, for an 04, i would go 22k-25k, there is no way i would pay 3 to 5 thousand over blue book excelent value
my advice go to BMW ask for a maintnace schedule for the potential car, as the service advisor if you could get an estimate for what each maintnance would cost and factor that into your decision,
look around and you will find somthing
Last edited by m4hk33; 04-15-2010 at 08:30 AM.
Good suggestion re asking for a maintenance schedule from the dealer - will definitely do that, thanks.
Sounds like you got an amazing deal on your 650! I agree we could find a lower price, especially as this car is a bit stripped. (My personal fave so far was a stratus gray 2005 645 that was loaded -HUD, heated seats, wood trim, 6-disc and 30k miles - the private seller dropped the price to $36k on the spot so I'm sure he'd go lower.) Docpaulo made a good point that these are dirving cars and problems show up when you drive them (not when it's resting in the garage) - so the low miles could almost be a liability...
Problem is, the hubby is now set on silver/grey top color combo and low miles....and I'm sure you guys don't like your wives nagging you re car choices...ARGH! But I'm a lawyer and very risk-averse, and I patiently and compulsively research things before making any decision. He just wants to find a car, strike a bargain, and drive off the lot - he initially didn't even want a prepurchase inspection!
somthing to consider, are you looking local only what is your search region? when i was looking for mine, i opened it to a nationwide search for the car that i wanted at a the price that i wanted, i.e,low blue book/trade in value, with CPO, it took about 6 moths but i found the exact car i wanted on the other side of DC.
basically find the car you absolutly love, options, miles, warrenty, color, coverage, what ever, at a great deal. when you find that car, that is thousands less then local, you can pay carchex or some other car evaluation firm a couple hundred bucks to verify its condition, and put it on a flat bed and have it delivered for less then a thousand bucks.
average nationwide price on autotrade is 31,k
the money save on finding the perfect car can buy a lot of maintnace down the road if you guys are going for an 04
m4hk33 - really good point also. That's how I bought my 325 wagon - I had to have manual trans. and heated seats, and ended up finding The One through a broker/auction in San Diego while we were living in Houston. I'd do the same for my next upgrade (which will be a 5-series manual, heated seats, HUD wagon - even if it takes 6 mos to find).
For the 6 we have primarily been looking locally for test drives, although have not ruled out looking further afield. I don't think Mr. Beemie could be as patient as you were, and there's obviously a trade-off in dollars for instant gratification... That's why I was trying to see if there were red flags raised with this particular car that would allow him to move on for the moment - or at least dig for more bargaining chips!
Thanks again for your thoughts - it's helpful to hear from others who are enthusiastic but also very calculated and deliberate in their purchases.
I looked for a long time and finally found mine, the perfect car. I'll explain why: The car was purchased from a local independent dealer whom I know. He was able to supply me with the complete history of the car from the day it was ordered, the two previous owners names, telephone numbers and addresses (granted very unusual), the entire service history of the vehicle, all the paperwork including windown stickers, the reason the right front fender was replaced, and a decent number on my trade in. The purchase price, as is, was $31,900 with 34500 miles on the car and is in pristine condition and needs nothing as I just replaced the horrible RFT's. It is a 2005 645Cic with the sports package, cold weather package, and premium stereo system. I added an Easy Care warranty and am all set.
The advantage that I had in this is that I purchased a convertible in November in New Hampshire. I also work as a senior manager at a major car dealership and "have been around the block."
Please take your time to locate the perfect example of one of these. Make sure that you have a PPI done by a BMW dealership whom you trust. If you are paying a premium price, as your car is, it should be flawless, that is no known issues at all!!
you should test drive a local car (which you did) to know you like it, then go nationwide and buy there... I would walk away (no run) from this car and dealer... you're getting an awful deal (not just average - awful)
I got my CPO from a BMW dealer in the east coast (I'm in WA state) and paid about 47K with CPO shipped to me... you can see my sig for the package I got...
for an 05 nothing more than 38K for fully loaded... for what you're looking 32-34K sounds about right...
dont' discount looking at BMW's website as that's where I found mine and we talked the price down a bit from their number...
get CPO if you can... it's worth the peace of mind...
you're hubby's a man... tell him he needs 360hp and 360 torque.. (650i) so he can go find an 06 or 07 even... we guys like HP so I'm sure he'll agree...
don't discount flying in to an out of state dealer and shipping or driving the car back... for the savings you'll be a few grand ahead...
07 650i Cabrio CPO, Titanium Silver
Black Matte Grill
Dark Birch Wood Interior and Shifter
HUD, Cold Weather and Sports Package
Logic 7 Sound
Aluminum Racing Pedals
K&N Air Filters
Rays Master Piece REM 20" Forged wheels w/ Conti Extreme DWS
I wudnt..
Greg A
650i on 22's Asanti, mtec v3 angel eyes, Custom exhaust...(retired)
2000 GS300 heavily modded(retired) gone but never forgotten
1998 LS400 Daily driver (retired)
2005 Range Rover HSE (family car) Lost in Divorce
BK650 and Docpaulo - thanks for your thoughts. Consensus definitely seems to be that we should not pay $38.5k for this car, which I suspected but didn't have a basis for. Sometimes it's hard to figure out what cars hav actually *sold* for (versus what the average asking prices are...) so your personal experiences help there. I know for the same asking price there is at least one '06 650 , still under factory warranty (for a few months anyway), better equipped in our area ... not the right color, but it shows they're out there, as you all know. And yeah.. I suspect that since he's a man, he secretly would prefer more HP, even though he's being impatient - I mean, he was talking about removing the 645 badge from the car already!!
Try cars.com i looked up there too...and if you are planning on spending $35K, i am sure you can get a 650i within 40K miles but depends on what color and if you are going for a Coupe or Vert may increase the miles a bit but definitely don't go over 50K miles.
And also don't try to spend everything on the car because you will need to buy the Extended maintenance and Warranty
2006 650i-Blk on Blk
I know about being impatient.... it took 14 days for them to deliver my car and I couldn't wait... but he'll be stuck with the car for a few years and getting the perfect one up front will make more long term sense...
must have's in my opinion...
1. cold weather package, the heated steering wheel is wonderful... since you're in SoCal, this may not be important for you... but it is to me
2. HUD - unless your near vision is bad (when you're in your 60's) then it's an awesome feature... once you have it, you can't go without it...
3. I like the dark birch color - but titanium silver is fine and others prefer the metal vs wood... it's a personal taste thing (light birch goes well with lighter leather color)
4. sports package is optional really as honestly you'll likely replace the tires and rims eventually and the M6 replicas look great and tire/wheel will run 2K+ and the shadowline trim vs chrome will make your car unique as well all have the dark trim but chrome's not bad...
5. 360hp/360ftlbs torque -- sorry to the 645 folks but a bit more power is just awesome - when you hit pedal to metal (plastic in reality) while in sport mode... snapping your head back to the headrest just reminds you why you're paying a lot for this car...
6. wind screen - runs about 450$ - tampamark will talk you into it if you're undecided...
7. comfort access although not a must is too convenient to pass up... start the car and leave the keys in your pocket... no more fumbling around... my keys are in a vest pocket of my coat and has been there for 3 mos without seeing daylight...
8. CPO or some BMW warranty keeps you sleeping better.. or a cash fund to offset repairs
9. rims are optional, but a man's gotta have new shoes sometime... so he's going to want some rims down the road... plan for it... the stock rims/tyres are not bad but could be better....
10. clean service history and preferrably brakes that got serviced/replaced just before warranty expired.
post pics when you eventually get on board and have him browse through the "what did you discover after buying your car" thread to see what other nifty features this car has...
07 650i Cabrio CPO, Titanium Silver
Black Matte Grill
Dark Birch Wood Interior and Shifter
HUD, Cold Weather and Sports Package
Logic 7 Sound
Aluminum Racing Pedals
K&N Air Filters
Rays Master Piece REM 20" Forged wheels w/ Conti Extreme DWS
I just bought my 650 convert three weeks ago.
2006 Dark Grey/ Black Top
41K Miles
Sports Package
Logic 7 System (does not have CD changer in glove box, but has I Pod adapter)
Metal Trim
Illuminated Door Sills (looks great at night when I open the doors)
Cold Package
3M protection on front and side of vehicle
Lojack system
Asking Price 45,000
Priced Paid $38,500.00 (however, have to pay additonal cost for extended warranty and BMW maintenance warranty)
I was also looking on ebay today, looks like your dealer is asking a little too much for this 645i, my advise would be to go on ebay print out some comparable prices and show it to the dealer. They will come down in price if they want your business. Good luck
here are the latest 06 650 conv sales sold at auction
Date Location Sales Price Mileage condition clr
You have received alot of great advice. Just for a comparison, I purchased my 05 645 Vert 8 months ago. It is a CPO car so I have plenty of warranty left if there are any problems. It had 49K miles on it when purchased. Options are Sport Pkg and Logic 7 system, wood trim package. Purchase price was $32,500...I feel very good with the deal I got although I did have to travel about 400 miles to get the car. The car has been great and I've not had any issues. Keep looking, you will find what you want at a fair price.
I'd consider this over the 645 you saw... the miles should not scare you as both are out of warranty...
just to give you and idea of what's available... but ultimately buy what makes you happy...
07 650i Cabrio CPO, Titanium Silver
Black Matte Grill
Dark Birch Wood Interior and Shifter
HUD, Cold Weather and Sports Package
Logic 7 Sound
Aluminum Racing Pedals
K&N Air Filters
Rays Master Piece REM 20" Forged wheels w/ Conti Extreme DWS
dunno if you found one but this may be what you're looking for...
other than brakes, I wouldn't worry too much about the miles.. and I'm sure that price is negotiable... and if you really want to you can spend more money on a BMW warranty...
shipping should be less than 1500$...
07 650i Cabrio CPO, Titanium Silver
Black Matte Grill
Dark Birch Wood Interior and Shifter
HUD, Cold Weather and Sports Package
Logic 7 Sound
Aluminum Racing Pedals
K&N Air Filters
Rays Master Piece REM 20" Forged wheels w/ Conti Extreme DWS
Last edited by docpaulo; 04-21-2010 at 11:55 AM.
I purchased a 2005 645 coupe, 23k miles in Oct. 08. I had a trade in which came from another dealer that I made the deal with and brought with me so I know figures are 100%. Black/Black, sport package, premium sound, satellite radio built in on I drive in factory radio which I love, wood trim, 6 CD in Glove, Cold weather, heated steering wheel, run flats, extended BMW 6yr/100K warranty, full maintenance, Road hazard wheel insurance, paid off the $825 it cost 2 tires 1 rim later, clean car fax, Illuminated door sills, Standard blacked out chrome around windows as with all BMW sport packages, New rubber, Every option available I think except HUD which I wish it had but car was so flawless I had to do it. It is absolutely perfect and aside from the tires and rim that I hit something that fell off a truck in the road (his exhaust system) The car, knock wood has been excellent with not one problem. Anyway my point, Oct, 08 about $42,000.00 and change from a BMW dealer certified pre owned with everything out the door including any taxes DMV Extended warranties, wheel insurance, 1 year satellite, the works and again had 23k miles so back then with everything mentioned from a dealer I think not a bad deal. I'm listing this for you to use as a reference. I think with what I got I paid high but it was a justifiable price, not too high and I need piece of mind so had to use BMW dealer with all available protection.
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I just got my third Olive Drab firearm. I like it, especially when you have a similar model eg. Glock 19, Glock 23 etc. It makes it more difficult to use the wrong ammo for a given firearm. I think it also gives the gun a kind of "military" look.
The only down side I see is maybe in resale, (some just have an aversion to cocky) but I don't buy a gun to trade it off.


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Digital Advertising + Marketing Summit (3/19)
Marquette University Diederich College of Communication
Wednesday, March 19, 2014 from 8:00 AM to 5:00 PM (CDT)
Who's Going
San Francisco, California
London, United Kingdom
Florence, Italy
Event Details
The 2nd annual Digital Advertising + Marketing Summit -- part of Marquette's Insight Summit Series -- will feature 14 sessions with speakers sharing their insights, expertise and experience on how to take your digital marketing to the next level.
Brought to you by the Diederich College of Communication at Marquette University and Laughlin Constable, the Digital Advertising + Marketing Summit is designed to cover the topics that matter to you most. We believe in case studies and actionable data. Explore the latest trends and tactics to help better engage with your customers.
Proceeds from the event benefit a scholarship fund for students of the Diederich College of Communication at Marquette University.
What you will learn. You will have the opportunity to listen to industry leaders discuss the strategies and frameworks used to best create, measure and optimize the digital advertising experience.
From planning digital marketing campaigns, through their execution, and measurement – attendees will walk away with an understanding of what's coming and how to begin to prepare for it now.
Who should attend? This conference is open to professionals and students. You can register for the student rate with a valid .edu email address.
Whether you are a veteran or new to digital marketing, the Insight Summit Series is a welcoming experience. Our sessions will provide the strategies, frameworks, and thinking behind the most pressing challenges organization face today.
Who will be there? The lineup features digital thought leaders from brands and organizations such as Rockwell Automation, Harley-Davidson Motor Company, Turner Broadcasting, CUNA Mutual Group, the Interactive Advertising Bureau (IAB), Advertising.com / AOL, Millenial Media and agencies such as Goodby Silverstein and Partners, Laughlin Constable and Raidious.
What topics will be discussed? Our speakers will discuss digital strategy, user-experience (UX), digital advertising, mobile, content marketing, ecommerce, SEO, data measurement, and more.
Looking to network? Last year's Digital Summit was a sold-out event, drawing over 500 attendees. Don't miss out on the opportunity to network and brainstorm with our speakers and attendees. We will also host a networking and cocktail event that evening at the Ambassador Hotel immediately following the conference.
We've got you covered. Attendees will enjoy a FREE continental breakfast, lunch and on-site parking.
Supporting students. Proceeds from the event benefit a scholarship fund for students of the Diederich College of Communication at Marquette University.
Register soon. The first 200 people to register will receive a free copy of the book "The Owned Media Doctrine," by Taulbee Jackson, one of our speakers.
Looking for updated information? Check out our Facebook and Twitter for the latest on the event. Join the conversation on Twitter, hashtag #MUISS.
Thank you to our sponsors: Marquette University and the Diederich College of Communication, Laughlin Constable, the Eisner Creative Foundation and the Big Shoes Network.
For more information, visit insightsummitseries.com
When & Where
Marquette University - Alumni Memorial Union & Weasler Auditorium
1442 W. Wisconsin Ave.
Wednesday, March 19, 2014 from 8:00 AM to 5:00 PM (CDT)
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Easy, but wrong. Why pick on the Roundtable? Why not the Agenda for Change Central Negotiating Group, which was wound up two years ago and rolled into the NHS Staff Council? The Northern Lighthouse Board, whose responsibilities include buoys? The defunct Activities for Managing Life Working Group, set up to tweak the "gateways" to the disability living allowance? The fabulously opaque National Network Forum? The Interchange Steering Council, which in a charmingly roundabout way "addresses barriers to interchange" between public and private sector employers? Or the Workforce Taskforce? Or the Poisons Board?
Keeping track of the hundreds of British quangos is a job so expensive and tiresome that even the Cabinet Office's Agencies and Public Bodies Team - "quangos" is not a term the government likes to use - doesn't want it any more. "It wasn't cost-effective," says a spokeswoman when asked why the official directory was taken off-line this year. So it is only by venturing deep into the department's archives that the dead and living branches of the UK's quasi-governmental bureaucracy are laid bare.
Here lies the Futurebuilders Reference Group, culled after it successfully delivered Futurebuilders - nothing to do with trainee brickies - to the Treasury; PHorum (the PH stands for Public Health) which the Cabinet Office says was renamed the NGO Forum, but on its own website insists that it is still and always PHorum; and the Urban Gull Leaflet Steering Group, which duly dropped its leaflet and flew off.
The naming of quangos is a difficult matter, and the Cabinet Office leaves individual government departments to do it. Understandably, the job of coming up with a title that implies both decisive action and bureaucratic rigour is often beyond the wit of civil servants. And paying M&C Saatchi to come up with a better moniker for the Retained Organs Commission would hardly go down well.
Once established, however, a public body or agency can rename itself, and the more active quangos like to do so regularly. It doesn't do to imply that your job is the same as it always was. The model to follow is the Ofwat National Customer Council, which rebranded itself as WaterVoice four years ago.
Sceptics take a dim view of this kind of rebranding. "What [quangos] are trying to do is essentially brand the public body with a name," explains Dan Lewis, the author of the Essential Guide to British Quangos 2005, "and in so doing you can demand more money."
It all made perfect sense to WaterVoice. "Our new name and separate voice will provide a clearer distinction between WaterVoice as the customers' representative and Ofwat as the industry regulator," explained its Yorkshire chairman. Not for long, though. The Water Act 2003 cut off the flow. On October 1 2005, WaterVoice was silenced and the Consumer Council for Water replaced it. Water palaver! The moral? You can lead a civil servant to a silly name, but even he won't necessarily swallow it.


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MRI will process games, sweepstakes, and contest winners, handline all prize fulfillment and making sure that prizes are distributed according to the Official Rules. We will work with your support vendors, tie-in partners, co-sponsors, and prize suppliers to ensure trouble-free prize fulfillment. We will also handle consumer inquiries and prize delivery, allowing you the freedom of knowing that you will have a satisfied consumer at the end of your promotion.
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Banned Members
Unfortunately the moderators have decided that member moamps should be banned. He has never been happy with the way this place is run and it seems never will be.
He has committed rules-breaking, threats and offensive e-mails to moderators, spread false information, and engaged in behind the scenes manipulation.
This was a majority decision of the moderators
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HOPEWELL,PATROLLED, IS LIKE AN ARMY BASE; Villagers, Aiding Baby Hunt, Are Hospitable to Crowds That Swarmed In.
HOPEWELL, N.J., March 5 (AP). -- The kidnapping of the Lindbergh baby has thrown this out-of-the-way hamlet of 1,800 persons into adventure and drama that grow more fantastic as the mystery drags on.
March 06, 1932
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Self Care for Older Persons in Singapore: An Intervention Study (SCOPE)
This study has been completed.
National University, Singapore
Information provided by (Responsible Party):
Dr. David Matchar, National University, Singapore
ClinicalTrials.gov Identifier:
First received: August 8, 2012
Last updated: April 15, 2015
Last verified: April 2015
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Show Detailed Description
The main aim of the project is to evaluate a self-care intervention program aimed at enhancing the ability of mildly disabled and healthy older persons in Singapore to manage their health.
A secondary aim of the study is to evaluate the effectiveness of training community health workers located within Senior Activity Centres in Singapore to support the self-care capacity development amongst older persons in the locale.
|Health Services, Geriatric
|Behavioral: Chronic disease self-management training
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Health Services Research
|Official Title:
|Self Care for Older Persons in Singapore: An Intervention Study
Resource links provided by NLM:
MedlinePlus related topics: Coping with Chronic IllnessU.S. FDA Resources
Further study details as provided by Dr. David Matchar, National University, Singapore:
Primary Outcome Measures:
- Clinical Measures [ Time Frame: 18 months ]The primary outcome measure is a composite of the change in the following measures: 1)Systolic BP; 2)HbA1C; and 3)normalized peak flow. The null hypothesis is that there is no difference between intervention and control in any of the measures.
Secondary Outcome Measures:
- Improved Quality of Life [ Time Frame: 18 months ]Improve quality of life of participants and their caregivers using a validated measure (EQ-5D).
- Community Health Trainer [ Time Frame: 18 months ]Develop a community health trainer capacity in low-income settings as assessed by numbers of individuals who successfully complete the health trainer education.
- Healthcare Utilization [ Time Frame: 18 months ]Reduce the number of hospitalizations, outpatient and emergency visits in the intervention group vs control.
|Estimated Enrollment:
|Study Start Date:
|August 2011
|Study Completion Date:
|October 2014
|Primary Completion Date:
|October 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
No Intervention: Control
Individuals in the control group will not receive any training.
Experimental: Intervention
Individuals in the intervention group will receive two hour long weekly training sessions for seven to eight months. The content of the training focuses on health promotion, health seeking behaviours and chronic disease management.
Behavioral: Chronic disease self-management training
Those in the intervention group will receive two hour long weekly training sessions for seven-eight months (a total of 56 hours of training).
Show Detailed Description
|Ages Eligible for Study:
|55 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age 55 and above
- Age 21 or above for CHTs
- No cognitive impairment as justified by AMT
- No Activities of Daily Living (ADL)Limitations preventing them from coming to questionnaire interviews, health screenings, and/or weekly health trainings.
- Not severely ill ; not on dialysis, chemotherapy or psychiatric medication
Exclusion Criteria:
- Below 55 years of age
- Cognitively impaired
- Severely depressed
- With ADLs preventing them from coming to questionnaire interviews, health screenings, and/or weekly health trainings.
- Severely ill ; on dialysis, chemotherapy or psychiatric medication
- Those who refused to have their biomarkers taken (applies to both intervention and non-intervention group)
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01672177
Please refer to this study by its ClinicalTrials.gov identifier: NCT01672177
|Redhill SilverACE
|Singapore, Singapore, 150071
|Moral Seniors Activity Centre (Redhill)
|Singapore, Singapore, 150089
|Moral Neighbourhood Link Bukit Merah View/Tanjong Pagar FSC
|Singapore, Singapore, 150118
|Kreta Ayer Seniors Activity Centre (Chin Swee)
|Singapore, Singapore, 160051
|Sarah Seniors Activity Centre
|Singapore, Singapore, 160105
|Kreta Ayer Senior Activity Centre (Jalan Kukoh)
|Singapore, Singapore, 162008
|AWWA Seniors Activity Centre
|Singapore, Singapore, 560123
|Ang Mo Kio Family Services Centre
|Singapore, Singapore, 560230
|Community Care Network Senior Activity Centre @Teck Ghee 420
|Singapore, Singapore, 560420
|Care Corner Toa Payoh
|Singapore, Singapore
|Lion Befrienders/TOUCH
|Singapore, Singapore
|Moral Neighbourhood Link Telok Blangah
|Singapore, Singapore
Sponsors and Collaborators
National University, Singapore
|Principal Investigator:
|David B Matchar, MD
|DUKE NUS Graduate Medical School Singapore
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by Dr. David Matchar, National University, Singapore:
ClinicalTrials.gov processed this record on June 23, 2017
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Chan A, Matchar DB, Tsao MA, Harding S, Chiu CT, Tay B, Raman P, Pietryla Z, Klein MK, Haldane VE. Self-Care for Older People (SCOPE): a cluster randomized controlled trial of self-care training and health outcomes in low-income elderly in Singapore. Contemp Clin Trials. 2015 Mar;41:313-24. doi: 10.1016/j.cct.2015.01.001. Epub 2015 Jan 10.
|Responsible Party:
|Dr. David Matchar, Professor and Director, Program in Health Services and Systems Research, National University, Singapore
|ClinicalTrials.gov Identifier:
|NCT01672177 History of Changes
|Other Study ID Numbers:
|Study First Received:
|August 8, 2012
|Last Updated:
|April 15, 2015
Keywords provided by Dr. David Matchar, National University, Singapore:
Chronic disease
Self management
ClinicalTrials.gov processed this record on June 23, 2017


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I feel like I've grown up...... and as a flashback to my early days here:
hopeful fett said:
Anyone else rememebr those days? It seems like so long ago to me, but I remember it so vividly.
Even if I never get my Boba or Jango started, I still found an awesome community here.
Thanks guys for making me feel welcome even during my more *ahem* stubborn times.


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Garlic-Rubbed Spareribs
Patricia Quintana loves to roast meat and fish in banana leaves, which add flavor and keep food moist and succulent. She cooks pork spareribs that way, then serves them with warm tortillas and bowls of garnishes alongside. You can also shred the sparerib meat, mix it with the onions it was roasted with and the pan juices and use the combination as a filling for the tortillas.
- Active:
- Total Time:
- Servings: 6
- 1/4 cup plus 2 tablespoons annatto (achiote) seeds
- 16 garlic cloves, 10 halved
- 1 medium onion, coarsely chopped
- 2 tablespoons dried oregano, preferably Mexican
- 2 tablespoons freshly ground pepper
- 1/2 cup fresh grapefruit juice
- 1/2 cup fresh orange juice
- 1/2 cup vegetable oil
- 3 racks large pork spareribs (about 3 1/2 pounds each), trimmed of excess fat
- Kosher salt
- 6 banana leaves, about 12 by 18 inches each (optional; see Note), thawed and patted dry
- 18 bay leaves
- 3 small red onions, thinly sliced
- Two dozen 6-inch corn tortillas
- Pickled Red Onions
- Yucatán Table Sauce
How to make this recipe
In a small saucepan, cover the annatto seeds with water, bring to a boil and simmer over moderate heat for 3 minutes. Remove from the heat and let stand for 2 hours. Drain the seeds and pat dry with paper towels. Transfer to a spice grinder and grind to a paste.
Preheat the oven to 500°. Put the 6 whole garlic cloves in a pie plate and roast on the top rack of the oven for about 10 minutes, or until blackened on top. In a food processor, puree the roasted garlic with the halved garlic cloves and the onion. Add the annatto paste, oregano, pepper, grapefruit and orange juices and oil and process until blended.
Rub the spareribs with 2 tablespoons of kosher salt. Set 1 of the racks in a large roasting pan and coat with one-third of the annatto marinade. Repeat with the remaining ribs and marinade, stacking the racks on top of each other. Cover with plastic wrap and refrigerate for at least 4 hours or overnight.
Preheat the oven to 350°. Line each of 3 large rimmed baking sheets with a banana leaf. Set a rack of ribs on each leaf, meaty side up. Arrange 6 bay leaves and one-third of the red onion slices on each rack and cover with a second banana leaf. Cover each pan tightly with foil and bake for about 2 1/2 hours, or until the ribs are very tender; shift the pans halfway through cooking. Remove the spareribs from the oven and let cool, covered, for 15 minutes. Meanwhile, wrap the tortillas in foil and warm in the oven for about 10 minutes.
Preheat the broiler. Uncover the ribs and discard the banana leaves, onions and bay leaves. Broil the ribs, 1 rack at a time, 8 inches from the heat, for about 4 minutes, until crispy; baste occasionally with the pan juices.
Cut the racks into ribs and serve with the warm tortillas and bowls of Pickled Red Onions and Yucatán Table Sauce.
Make Ahead
The recipe can be prepared through Step 3; refrigerate overnight.
Banana leaves are available in the freezer section of Latin and Asian markets and in the fresh produce section of some supermarkets.
Suggested Pairing
A spicy, fruity California Zinfandel will have the intensity to balance the meaty ribs. A dark Mexican beer is also fruity enough to stand up to the hearty grilled flavors.


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