text:
As I mentioned, I plan on adding some different content to the blog as my "search for balance" has been rocked with this new addition to our family. Enter...Life of a New Mama!
One of the first things that crossed my mind, once we were home from the hospital, was "How in the world am I going to maintain supper time?" Cooking and eating healthy are two very important components in my life. Cooking has always been a way for me to decompress, and being gluten free requires a lot more eating at home. How in the world do you do that with a newborn that wants to nurse at all hours of the day? Well, between Pinterest and my Slow Cooker we have had dinner every night.
Here are some of my favorite new recipes:
French Dip Sammies
Easy Peasy Pulled Pork
Sweet and Sour Chicken
Each of these recipes were easy to tweak to make gluten free. I just had to use tamari instead of soy sauce, gf rolls for the sammies, and double check things like the bbq sauce to make sure there were no sneaky ingredients.
What are your favorite slow cooker recipes?


text:
It's For You...
New episode of "The 40 Year Old Boy" podcast now empty and aching and I don't know why. Maybe it's the weather; as I type this it's 84º at 5:15 AM, with no real hope for relief later today. I should point out that I don't mind; if given the choice, I would absolutely die in a fire rather than freeze to death. Of course, that seems a little extreme here - why can't I just say "I like summer", and leave it at that?
Hey, have I mentioned my love of semi-colons? I really don't need to, as any entry I type will drive that message home with a vengeance. I need to get a new punctuation crutch - maybe brackets? Yeah, I never use fucking brackets. [They are definitely the move].
Special guest on this week's video, as I decided not to force you to observe me twisting in agony searching for the funny. Instead, meet Dog Puppet, one of the many magical creatures who reside in Lili Land. Next week we'll meet any number of wig heads, and about forty-five pictures of The Flash. The Clown is apparently a fan.

subset: commoncrawl


text:
We bring forth unparallel Diary Cover Printing services for the clients all over the country. Our Diary Cover Printing services are handled by skilled professionals who are working in the industry since long. Therefore, we can assure customers that our Diary Cover Printing services are completely as per their expectations. We take care of every minute detail in terms of content, paper quality or ink quality, etc. bef
Laxmi Press
Pankha Wala Bag, Kasganj, Uttar Pradesh , India
The clients can avail the best Pillow Printing Services in Agra through our company. The company has employed a team of trained & experienced designers that has years of experience in the domain of Pillow Printing Services. The high quality dyeing through modern dyeing techniques is the hallmark of our Pillow Printing Services, and the resulting patterns and multicolor combinations are simply unmatched. The Pillo
Tarun Video Graphics
D-715 Kalindi Vihar City - Agra State - Uttar Pradesh, Uttar Pradesh - 282006, India
Vama Industries
F-28, Sector 11, Uttar Pradesh - 201301, India
Geeta Prints
E-169b, 1st Floor, Sector-7, Gautam Budh Nagar, Uttar Pradesh - 201301, India


text:
Update (24/05/2014): I have recently discovered that Chromium (Desktop) has dropped support for the
text-size-adjust CSS property name rendering the original solution below invalid. The alternative solution is still functional. It is not a bug as far as I am concerned. It is related to the user's Chromium preferences, and it is not advisable to override them.
Why does my website's font-size appear larger on other screens? Or why does it not appear as intended?
A minimum font-size of 12px is set for Chrome users with a special, foreign UI locale (language) - e.g. Chinese, Korean, Japanese, Thai etc. If however, the font-size for any content on your website is set to a value that is less than 12px, it will automatically be resized to 12px. WebKit - the web browser engine behind Chrome which handles the parsing and layout of websites - however, does support font-sizes of 12px and under. Indeed, for most UI locales, Chrome has set the minimum font-size to 1px (simply: anything smaller will be resized to 1px). The way Chrome behaves when dealing with special UI locales may become problematic for web designs relying heavily on magic numbers or typography. Indeed, other users and developers seem to be raising similar concerns about this behaviour and its adverse impact:


text:
Editor's Note: TMJ received the following release about this promising young Breckinridge TX native.)
Sidewalk/Curb recording artist Morgan Frazier announces that her debut music video, "Hey Bully" world premiered on act.mtv.com. The video addresses tough, real world issues and does not shy away from the truth about bullying. Frazier, who was picked on herself, to the point where she was taken out of school and put in home school, co-wrote the impactful country tune with Sherrie Austin and Tiffany Goss.
"I am so glad that MTV is helping to bring this issue to the forefront, and I applaud act.mtv.com for encouraging folks to truly act on this and to join Stand For The Silent and myself. "I've had the pleasure of working with Kirk and Laura Smalley of Stand For The Silent everywhere from middle and high schools to major corporate headquarters to address bullying head on. The effects of bullying and the tragedies it can leave behind in today's world must end. We made this video in an effort to get parents, kids and educators talking about the reality of this issue and to teach kids that suicide is not an option. One child lost is one too many," says Frazier.
View the World Premiere of the video at: http://bit.ly/HEYBULLY
Frazier has partnered with Stand for the Silent (SFTS), whose mission it is to bring global awareness to the disturbing issue of bullying in today's society. SFTS has been a part of Director Lee Hirsch's feature film, Bully, as well as The Bully Effect, a documentary on CNN's AC360. SFTS was started after Kirk and Laura Smalley's son Ty committed suicide in May of 2010 following a school suspension for defending himself against a bully. In their pledge to never stop the fight against school bullying, Kirk and Laura conduct Stand for the Silent presentations at middle and high schools all across the world.
According to Stand For The Silent, the statistics on bullying are alarming:
•Every 7 seconds a child is bullied in this world
•160,000 kids stay home from school every day due to fear of bullying
•25% of high school students in America will actually have a plan to take their own life before they graduate
"Hey Bully" is available now on iTunes: http://bit.ly/heybully
Kids and adults alike can take the SFTS pledge to stop bullying at: www.standforthesilent.org
About Morgan Frazier:
Recognized in Country Weekly's "Ones To Watch in 2013," Morgan Frazier's remarkable journey began in a small Texas town where she made her way to Nashville by literally going door-to-door. At just nine years old, Morgan recorded her first CD in her hometown of Breckenridge, Texas. Although they had no formal plans to market or sell the CD's, Morgan's family believed in their little girl's talent and ordered one thousand copies. For the next two years, Morgan and her family traveled all over the South and Southwest selling over thirty thousand copies of her album. At the age of sixteen, Morgan followed her dream to Nashville where she perfected her songwriting craft and honed her chops at the legendary Tootsie's Orchid Lounge. Not long after, she signed a publishing and recording contract with Curb Records' imprint Sidewalk Records. Having experienced bullying first hand, Morgan co-wrote her latest single, "Hey Bully" to bring awareness to the growing epidemic.
About Stand for the Silent:
Stand for the Silent exists as a platform to allow Kirk and Laura Smalley to share their story and offer education and tools that will prevent their tragedy from happening to another child and family. Kirk and Laura's mission is to continue to change kids' lives and bring awareness to bullying and the real devastation it causes. Since May 2010, Kirk and Laura Smalley have traveled to hundreds of schools and spoken with more than 700,000 kids. In March 2011, Kirk and Laura met privately with President Obama and First Lady Michelle Obama in The White House prior to attending the first ever White House conference on bullying. Their story is featured in Director Lee Hirsch's feature film, Bully. Kirk and Laura have been invited to a number of conferences on bullying and met with Lady Gaga this spring at the launch of the Born This Way Foundation.
Posted by: Sam Moore
Tags: Morgan Frazier, Texas music
You must be logged in to post a comment.


text:
This workshop is an introduction to the neo-classical devotional dances of Persia. Many dances have been inspired by Sufi poetry as well as depicted from miniature art. The depth of feminine grace can be discovered in this beautiful ways a women articulates her wrists, body gestures as well as angles of the body.
Contact the organizer for latest event info. Kodoom.com is not responsible for any changes made in the above information. Report or Flag this event


text:
How it works
We research your business, your competitors businesses, your industry and your target audience.
Using this knowledge we craft a design that is, simple, memorable, timeless, versatile and appropriate for more information on this see our 5 simple rules for great logo design.
We apply your new branding consistently in print and online so every aspect of your business is unmistakeably 'you'. More customers want to know about you, more customers learn to trust you and more customers buy your products. Mission complete.
"If you're going to develop your brand, the last thing you want to do is follow the beaten path. You want to head down your own road. Your brand has to plant itself in the hearts and minds of customers."
Lois Geller – Forbes Magazine
What is branding anyway?
What a brand is not_
Your brand is not just your logo,
your identity or your product.
What a brand is_
It is the feeling a person experiences when they come into contact with your product or service.
Why you need good branding_
People are bombarded with similar looking, similar featured and similar priced products. They have too many choices and too little time. How do they decide which one to buy? They do it on trust.
Branding that people trust
Building trust is a tale of two halves- reliability and delight.
You create reliability_
Your business must provide a consistently high quality product or service.
Gorilla creates the delight_
We craft well considered, visually appealing design that creates a positive feeling whenever a customer comes into contact with your brand. People who trust your brand, buy your brand- every time.


text:
China's Ming Yang To Build 2,500 MW Of Wind Power In India
Under the agreement, Ming Yang will handle engineering, procurement and construction of the projects. Reliance Power, India's biggest power producer, will help market the power.
China Development Bank will act as the coordinating bank and potentially the lead lender for the projects.
"We are very pleased to work with Reliance...
To view the full article, register now.
Try Law360 FREE for seven days
Already a subscriber? Click here to login


text:
Interested in receiving support from the CSHF? We may be able to support your research efforts financially and/or by providing you with DNA from Clumber Spaniels.
The Clumber Spaniel Health Foundation accepts proposals all year long. All applications will be reviewed by our Scientific Advisory Committee and our Boad, a decision will be made within 45 days.
Submissions should be sent electronically to the Foundation Secretary at .
As we are a small foundation, it is important for us to focus on studies that either have an important incidence rate in Clumber Spaniels or in dogs in general, and that also have the potential to move science in a direction that will allow for screening, prevention or treatment.
Proposals should be a maximum of 12 pages and include:
Please be advised that we strictly fund data gathering, clinical scientific research per se.


text:
Download War Tank Racing apk 1.0 free for Android smartphone
23 May
War Tank Racing
Posted by Ginger Games in Racing | May 23, 2014 | 0 Comments
Apk file size: 33.0 MB
Are you crazy about army and defense games ?Then this is the game for you!
Drive and destroy your way to glory...
Get ready, it's time to challenge the players that rule the game.
War Tank Racing combines stunning, high-fidelity graphics with addictive gameplay.
Ginger Games part of our Racing and have average installs from 1 to 5. Last Update May 23, 2014. Google play rating is 100.0. Current verison is 1.0. Actual size 33.0 MB.


text:
How to remove your Experian Credit Expert account
From their FAQ (http://experian.metafaq.com/help/CreditExpertBRS/Cancel_and_duration/CancelBRS):
To cancel your membership please call us on free phone 0800 561 0083 (Monday – Friday 9am until 6pm and Saturday 9am until 1pm).
Helpful Trick: Removing online data
Publicly visible text/images often aren't properly removed even when you succeed in removing an account. Try editing or removing them manually before removing the account itself. If you're unsure what happens to your tracks: this can be found mostly in the Terms of Service/Privacy Policy; otherwise you can always contact Experian Credit Expert and ask personally. By the way, removal requests don't necessarily mean your data will actually be removed (e.g. due to legal obligations).
Helpful Trick: Remove third-party logins
If you signed up for Experian Credit Expert using a third-party login such as Facebook or Twitter, you probably want to revoke all access from Experian Credit Expert. Click here to find out how.


text:
Please enter your username or email address. You will receive a link to create a new password via email.
Your password reset link appears to be invalid. Please request a new link below.
Username or E-mail:
Username or E-mail
Remember Me
Hockomock Area YMCA
Contact us about being a Partner!
Home Depot
Paradise Valley Dermatology
S. R. Construction
Contact us about being a Sponsor!
Copyright 2016. RWL Weightlifting, 72 Grove Street, Franklin, MA 02038 a 501c(3) non-profit. Building Strong PEOPLE Through Weightlifting. All Rights Reserved.
Get every new post on this blog delivered to your Inbox.
Join other followers:


text:
You've probably heard for a while now that programmable thermostats save you money. In fact, Energy Star estimates that you can save approximately $180 each year in energy costs when you switch to a programmable thermostat. But these thermostats have a catch. You have to use them correctly to see the savings. Use the following guide to get the most out of your thermostat.
Pick the Right Model
If you have yet to buy a programmable thermostat, be careful with the model you buy. Although these thermostats offer more environmentally friendly benefits than their traditional partners, you still need to select a model that best suits your home and lifestyle.
5+2 Model
This model allows you to set one program for the week (5 days) another for the weekend (2 days). If you keep a consistent schedule, and your weekends don't differ too much from each other, you'll want to stick to this simpler model.
5+1+1 Model
With this model, you can set a program for the week, as well as two separate schedules for each of your weekend days. For example, if you typically run errands on Saturday, you might not want as much heating as you would when you stay home on Sunday.
7 Model
When you pick this model, you enjoy the most flexibility. It allows you to create a different program for each day of the week. If no two days feel the same in your home, you may wish to select this model to accommodate your busy schedule.
Install the Model Correctly
Now that you have a new thermostat, take the time to consider its installation. Where you put your new thermostat and how you install it has just as much effect on your savings as how you use it.
Choose the Appropriate Location
To maximize savings, you want your thermostat to take accurate temperature readings in your home. If your thermostat sits next to a drafty window or sunny skylight, it may read the room's temperature as lower or higher by a few degrees. Place your thermostat in an area where natural air currents (cool air sinking and warm air rising) occur. Avoid placing furniture near your thermostat, as it will block these currents.
Follow the Manual
Although installation may seem simple at first, you'll want to carefully read the manual in its entirely before you mount the thermostat on your wall. If installation involves more than 10 wires, contact a professional to install it for you.
Consider Zoning Your Home
Your home likely has inconsistent temperatures throughout the building. For example, your living room with its large bay windows likely has more light and heat than your bedroom shaded by those gorgeous pines. Although a single thermostat can measure the temperature in your main room, it might have difficulty accounting for those other rooms.
To save more energy, have an expert zone your home, dividing it into two or more sections with a thermostat in each section and dampers in the ducts. This division allows you to send heated or cooled air where you want it the most.
Choose Appropriate Settings
Everything installed correctly? Good. Now you feel ready to use your thermostat. Use these tips as a general rule of thumb.
Select Reasonable Temperatures
Many homeowners misunderstand how thermostats work. They crank the temperature to 50 degrees a few minutes before they arrive home in hopes that the cooling will work faster. However, most heating and cooling units require at least an hour to reach a set temperature, and some require even longer.
If you require precise temperature control, consider a thermostat with adaptive recovery technology. These devices learn how your unit takes to cool your home so they can reach an ideal temperature in the most efficient time.
Avoid the Temptation to Override Manually
Programmable thermostats have a manual override button, which offers a great deal of convenience. However, you'll want to avoid this button as much as possible to ensure the most savings.
On particularly hot or cold days, don't give into the temptation to temporarily interrupt or adjust your settings. Each time you do so, you'll spend more money on utilities. Some experts estimate that if you run your heater one degree warmer over the course of a month, it will raise your heating by at least 3% for that month.
Plan for Vacation Time
If you plan to leave for a few days, don't waste energy heating or cooling your empty home. Instead, use your thermostat's hold/permanent/vacation setting to manage the temperature when you're gone. Set it to an efficient temperature for the season (several degrees warmer in summer or cooler in winter).
Need More Tips?
With the above tips and techniques, you'll see more savings on your monthly utilities. However, this list is far from comprehensive. For more ways to save, talk to your local HVAC technician. He or she can assess your home and recommend ways to improve energy efficiency.


text:
This website uses cookies to improve your shopping experience. For more information, click here. By clicking "OK" or by continuing using this website, you agree to our cookies policy.
76 High Street - WR1 2ET Worcester
Monday : 09:00-17:30Tuesday : 09:00-17:30Wednesday : 09:00-17:30Thursday : 09:00-17:30Friday : 09:00-17:30Saturday : 09:00-17:30Sunday : 10:30-16:30
Use the search engine to know if your product is available in this store
Or check if the product is eligible for Click and Collect
Sign Up to Our Newsletter!


text:
Unilever Wins Bid To Transfer Breyers Suit To Calif.
Unilever had moved to dismiss, stay or transfer the suit, and Judge William H. Walls of the U.S. District Court for the District of New Jersey granted the motion to transfer the case to the U.S. District Court for the Northern District of California.
Judge Walls...
To view the full article, register now.
Try Law360 FREE for seven days
Already a subscriber? Click here to login


text:
Grazing on "Jesus and the Jewish Roots of the Eucharist" – Foreword
Me vida commented the other day that I am a gluttonous reader.
She's right.
Most of the time I read greedily. I shovel down page after page with hardly a pause, as if fearful that Adam will drink the last Miller Light, or Samuel will snag the last slice of pizza. Some books (e.g. The Stainless Steel Rat) deserve to be enjoyed this way. Others should be savored, pausing frequently to consider the interplay of scents, flavors, and lingering tones. The art of reading well is to know the author, genre, and style well enough to enjoy each book appropriately. It would be just as wrong to attempt to savor a can of Miller Light as to chug a malt glass of Laphroaig 30 Cask Strength.
An old gospel preacher once commented that we are indeed sheep: we trample more green pasture (Psalm 23) than we ever graze . I picked up Dr. Brant Pitre's excellent Jesus and the Jewish Roots of the Eucharist this morning, and decided to re-read it grazingly instead of gluttonously. Rather than speed-read my way through, eager to move on to the next in my enormous backlog of books, I'm going to force myself to stop when something strikes me, meditate upon it, then consider whether I should continue reading immediately, or set it aside to allow time to savor the goodness.
I made it to page x of the foreword.
Scott Hahn writes in the foreword that "Love transforms suffering into sacrifice."
He goes on to say
Saint Paul preached: "I appeal to you therefore, brethren, by the mercies of God, to present your bodies as a living sacrifice, holy and acceptable to God, which is your spiritual worship" (Romans 12:1). Note that he speaks of "bodies" in the plural, but "sacrifice" in the singular. For we are many, but our sacrifice is one with Jesus' own, which is once for all. (Heb 7:27, 912, 9:26, 10:10)
Love transforms suffering into sacrifice.
- Discovery – David Clayton, artist and lecturer at Thomas More College of Liberal Arts
- Review on The Great Divorce by C. S. Lewis


text:
flickr photostream
TagsArt BARS beer cheapoair christmas cocktails coffee competition Drink east london Food free freebies Graffiti hackney hotels LDP London London blog London Daily Photo Londonist london photographer luxury mayfair OneTravel Photography photography blog restaurant restaurants review reviews Shopping soho south london SPONSORED POST street art street photography Travel twitter competition W1 wine Лондон لندن ロンドン 伦敦
Tag Archives: The Olive Exclusive
Best Hotels and Resorts of 2016
Nicest digs on the planet? Here are a few of 'em! 2016 was one of the best years of travel for me yet. What made the year such an amazing time to ramble was, in large part, where I got to lay my head at night. Continue reading
Posted in Best of 2016, Best of the Best, California, Hotels, Jamaica, Luxury, Namibia, Samoa, Travel, USA Tagged africa, Andersson's Camp, Best of 2016, Best of Hotels of 2016, Best of Resorts of 2016, Best of the Best, california, California 92648, California 94108, Damaraland, Doro Nawas, Doro Nawas Camp, Etosha, Half Moon Hotel, Half Moon Montego Bay, Hoanib Skeleton Coast Camp, hotels, Huntington Beach, jamaica, Kimpton Shorebreak Hotel, Lefaga, Little Kulala, luxury, Matautu, Montego Bay, Namibia, Ongava Game Reserve, Orange County, Pacific Coast Highway, Promenaden Road, resorts, Return to Paradise Resort, Rose Hall, safari, Samoa, san francisco, Skeleton Coast, sossusvlei, The Fairmont San Francisco, The Fairmont San Francisco Mason Street, The Olive Exclusive, The Royal Villas at the Half Moon Hotel, Travel, USA, Wexas Travel, Wilderness Safaris, windhoek Leave a comment
Namibia | Etosha
Thoroughly well rested from my relaxing stay in Windhoek and more than ready for some serious safari action, I hit the road en route to the first lodge one my itinerary: Andersson's Camp, set within Ongava Game Reserve on the border of (and with its own private gate to) Etosha National Park. Continue reading
Posted in Hotels, Luxury, Namibia, Namibia 2016, road trip, Travel Tagged africa, Andersson's Camp, Etosha, Etosha National Park, Etosha Pan, hotels, luxury, Namibia, Namibia 2016, Namibia in Style, Namibia in Style Self-Drive, Ongava, Ongava Game Reserve, road trip, safari, southern africa, The Olive Exclusive, Travel, Wexas Travel, windhoek 2 Comments
This was my first time in Namibia, but not the greater southern Africa region. I've been heading down to this gorgeous part of the world since the mid 90s (and even lived in Mozambique for about a year) – always encountering enthusiastic folks insistent that I get to Namibia but never quite being able to take them up on their advice. But now I've finally made it, and I can see what the fuss had been all about it. Continue reading
Posted in Cars, Design, Hotels, Luxury, Namibia, Namibia 2016, road trip, Shopping, Travel Tagged addison lee, addison lee app, addison lee minicabs, africa, binoculars, cars, CL Pocket, design, Europcar, Groov-e, Groov-e Power Pack, hotels, luxury, Namibia, Namibia 2016, Namibia in Style, Namibia in Style Self-Drive, Nissan X Trail, Nisson, road trip, safari, Shopping, South African Airways, southern africa, Swarovski binoculars, Swarovski Optik, Swarovski Optik binoculars, Swarovski Optik CL CL Pocket, Swarovski Optik CL Pocket binoculars, The Olive Exclusive, Travel, Wexas Travel, windhoek, X Trail 2 Comments


text:
The playground situated in the Acacia Street in Den Haag required a "facelift". The existing play units were old and had to be replaced.
A working group from the local neighborhood and the town chose play equipment made of robinia wood from eibe's new product line of paradiso.
In addition to a great climbing device, there is a bird's nest swing, a three-level horizontal bar, and a sand and water-play area. The playground is located in a semi-public neighborhood and is very well received.


text:
You can liven up a trip to the store considerably – and create some mental images you may never be able to get out of your brain – if, as you walk through the store, you ask yourself:
What three things should never be on the checkout lane at the same time?
Let your creativity flow! Bonus points if you check out with #threethings and the clerk gives you a funny look.
Note: Rubber gloves are always funny.


text:
Woods Wire 7-Outlet Surge Protector Power Strip with 10-Foot Cord – Link
Amazon has this currently at $12.99. Plus, clip the 15% off coupon below the price, bringing the total to just $11.04.
- 1250 Joules of protection
- 7-outlet
- Cord length is 10-Feet.
- Premium protection for sensitive electronics.
- Long cord gets outlets where you need them.
- Sliding safety covers prevents accidental contact and keeps dust and debris away from unused outlets.
- $150,000 connected equipment warranty.


text:
Watch video: Drunk dance with builders on beach costs 12 Vasai-Virar civic engineers dear
The Vasai-Virar municipal commissioner has suspended 12 officials of the encroachment department, including the chief engineer, for allegedly attending a party thrown by a builder and even getting drunk and dancing
Vasai-Virar Municipal Corporation engineers dance at the party thrown by a builder at Vasai beach
The Vasai-Virar municipal commissioner has suspended 12 officials of the encroachment department, including the chief engineer, for allegedly attending a party thrown by a builder and even getting drunk and dancing.
The commissioner cracked the whip after a video of the party, where the civic officials can be seen drinking and dancing, went viral.
Chief engineer Swaroop Khanolkar was among the 12 who were suspended
Cracking the whip
The video of the party at Vasai beach arranged by some builders and contractors to celebrate the birthday of chief engineer Swaroop Khanolkar went viral yesterday. Officials can be seen dancing to item numbers, with firecrackers being burst at the end.
Municipal commissioner Satish Lokhande suspended Khanolkar, Narendra Sankhe, Roshan Bhagat, Pravin Mulik, Yuvraj Patil, Indrajit Patil, Keyur Patil, Yogesh Sawant, Parmjit Vartak, Nilesh Kore, Kaustubh Tamore and Ninad Samant.
These engineers have been accused of helping the builders to carry out illegal construction and of providing the contractors with JCB and pokelane machines for demolition.
Khanolkar has landed in a soup in the past too - he was suspended in 2015 for not demolishing an illegal building.
Civic chief speaks
"I saw the video in the morning. On inquiring, I was told that this party had happened a month ago. I also found out that the organisers of the party were related to some builders and were the ones helping them carry out unauthorised construction. These engineers brought disrepute to the corporation with their action. Hence, I ordered their immediate suspension till the inquiry gets completed," said Lokhande.
mid-day tried getting in touch with Khanolkar, but he remained unavailable for comment.
Watch video here


text:
Build Guide by KALUHS
Not Updated For Current Season
This guide has not yet been updated for the current season. Please keep this in mind while reading. You can see the most recently updated guides on the browse guides page.
Thank You!
Your votes and comments encourage our guide authors to continue
creating helpful guides for the League of Legends community.
Jax Build
Top Lane
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Hey I've played Jax to an extensive amount and just like his character bio says I find him unbeatable allowing me to achieve many win streaks.
Pros / Cons
Unbeatable Toe to Toe against any champion (yes Jax is #1)
High Dodge
High Burst
High DPS
Very GOOD escape/chase skill
Amazing low cool down Stun
BRUISER (tanky/dps)
Hard to Counter
The only thing that can stop Jax is CC, skill spam, and focus fire but that would kill any other champion rite?
Early Game Strategy
Take mid lane
-Depending on who u may face in mid lane ur starter items can vary from Long Sword+hp pot (to get ahead on building that phage), Cloth armor+5hp pot(vs heavy harassers , Vamp Scepter (vs hp restoring champs such as vlad)
-Focus on last hitting if the enemy champion makes u fall back just be patient and tower hug
-Once u have all 3 skills empower+leap+Stun(if available)+echaust+ignite this should surely get u a kill or make them return home.
-Get ur Ninja Tabi and Vamperic Scepter Asap as these 2 items will give u a much stronger laning power
-Phage+bilgewater+exhaust will allow u to chase and kill targets
-once you build ur rageblade ur set on the path of destruction
Mid/Late Game team fight Strategy
-If ur not being focused then they are allowing u to be jax gaining attk speed stax and bursting down champs
-if they all focus u leap away and get rite back in the fight the moment they switch target
-u can take a hit but it be best to burst down a champ lose the attention and continue.
-if ur being focused by auto attackers ur in the green, stun and demolish them all


text:
could anyone tell me if Neimans or Nordstroms carry mulberry bayswater bags? thanks
Good question! I'd like to know the answer to that! There are two Mulberry stores in New York City. I've seen Mulberry in Saks in New York, but nowhere else. Hard to find these days.
That is very true, if you are in NY or LA, apparently there are Mulberry stores and Netaporter has the Bayswater right now, but otherwise, you order from Mulberry online via UK. I have seen Mulberry in Nordstrom, but only the new styles, not the classics which are the ones I want, i.e. Bayswater and Roxanne. Someone said they saw Bayswater at Nordstrom but that's not the case where I am. I was also in Nordstrom and Bloomingdales in SF and there weren't any there either. I am planning on Netaporter in a few weeks.:s
thanks, gatsby i've never seen the bag. i guess if i had to, i would purchase from netaporter...just didn't want to return to netaporter and settle with a store credit due to the no refund policy.
Gatsby, the Nordstrom in Valley Fair San Jose has (or used to have) Mulberry. It might be a bit far for you to drive down to the South Bay. I should go check them out tomorrow, haven't been there for a while.
The Bayswater is a great choice, i got mine last year in the Darwin leather, and it looks amazing now.
I'm in England, so don't have trouble finding a store, but hey... you have Macys, Bloomingdales, Abercrombie... oh and great boutiques. which really is far better..
Net a porter is a great suggestion though.
I'd love to know if anyone has found Milberry in any US outlet stores?/
Someone posted about finding a couple of them at Nordstrom Rack, in San Leandro, CA. Any NR near you?
i think mulberry hasn't sold well in the us so neiman's has stopped carrying it and some nordstroms carries a limited selection. i believe saks has stopped too -- all the bags at my store went on sale and i haven't seen new ones.
Mulberry is opening their own stores in the US, that's why they no longer selling to the other department stores here, or not as many as before. There is a thread on that...
You could always order direct from www.mulberry.com
They have their flaghsip Mulberry stores in Ny- in or near Bleeker Street and on Fifth Ave
When I last checked a couple of months ago, Mulberry was no longer carried in Neiman Marcus, Saks, or Bloomingdale's in San Francisco and there was a small selection at Nordstrom in SF. But on a more recent visit to Nordstrom I see that they've put more Mulberrys out for display, especially the newer styles like the green Smithfield. A sales associate also told me that they have more styles in the back but they rotate them because there isn't enough room to display everything.
I saw a few Mulberry at Nordstrom today too. Some with snakeskin look, or real snakeskin. But no Bayswater.
In the UK they could always be bought in high end department stores: Selfridges, Harrods, John Lewis, House of Fraser etc as well as lots of little shops but from what I gather Mulberry is not going to be supplying any of these shops anymore. I must say I always thought Mulberry didn't have the exclusivity of say Chloe or Balenciaga because you could just buy them in John Lewis or your local travel goods shop amongst Radley bags etc but I think that it is a shame for all the shops that have been loyal to Mulberry and sold it for years. As Mulberry has taken off over the last few years I think they want it yo become more exclusive and are going to soon just be selling it from their own stores.


text:
Ferroportin (Fpn), a ferrous iron Fe(II) transporter responsible for the entry of iron into plasma, is regulated post‐translationally through internalization and degradation following binding of the hormone hepcidin. Cellular iron export is impaired in mice and humans with aceruloplasminemia, an iron overload disease due to mutations in the ferroxidase ceruloplasmin (Cp). In the absence of Cp Fpn is rapidly internalized and degraded. Depletion of extracellular Fe(II) by the yeast ferroxidase Fet3p or iron chelators can maintain cell surface Fpn in the absence of Cp. Iron remains bound to Fpn in the absence of multicopper oxidases. Fpn with bound iron is recognized by a ubiquitin ligase, which ubiquitinates Fpn on lysine 253. Mutation of lysine 253 to alanine prevents ubiquitination and maintains Fpn‐iron on cell surface in the absence of ferroxidase activity. The requirement for a ferroxidase to maintain iron transport activity represents a new mechanism of regulating cellular iron export, a new function for Cp and an explanation for brain iron overload in patients with aceruloplasminemia.
Ferroportin (Fpn) is the only known mammalian cellular iron exporter and is present on most cell types that deliver iron into plasma (Ganz and Nemeth, 2006). Expression of Fpn leads to export of iron and a decrease in the cellular iron storage protein ferritin (Nemeth et al, 2004). Fpn is regulated by several mechanisms, but particularly through its interaction with hepcidin, a peptide produced by the liver in response to iron stores, erythropoiesis, hypoxia and inflammation. Hepcidin binds to Fpn, resulting in its internalization and degradation. The removal of Fpn from the cell surface completes a homeostatic loop in which iron transport is coordinated with iron need. Most hereditary iron overload diseases can be explained by inadequate production of hepcidin in response to iron stores or by mutations in Fpn (Pietrangelo, 2006). Conversely, increased expression of hepcidin as a result of inflammatory mediators leads to the clearance of cell surface Fpn. This decrease in Fpn prevents iron export, leading to a precipitous drop in plasma iron (hypoferremia), which if persistent results in an iron‐deficient anemia referred to as the anemia of chronic disease or chronic inflammation. Thus, the presence of cell surface Fpn may be the critical determinant in mammalian iron homeostasis.
In humans and mice, loss of function mutations in the multicopper oxidase ceruloplasmin (Cp) lead to excessive iron accumulation in the liver and in various regions of the brain (Harris, 2003), as well as hypoferremia and iron‐limited erythropoiesis. Multicopper oxidases, which catalyze the oxidation of four atoms of Fe(II) to Fe(III), have essential roles in iron metabolism in all eukaryotes. In Saccharomyces cerevisiae, the high‐affinity iron transport system consists of the multicopper oxidase Fet3p and the transmembrane iron permease Ftr1p. Both proteins must be synthesized together for either to be targeted to the cell surface (Van Ho et al, 2002). In vertebrates, Cp and hephaestin generate Fe(III), which binds to the plasma protein transferrin, enabling delivery of iron to developing red blood cells and other tissues (Shim and Harris, 2003). Here, we show that an additional function of multicopper oxidases is to stabilize Fpn on the cell surface. Inhibition of Cp activity or synthesis prevents stable expression of Fpn on the surface of glioma cells, astrocytes and macrophages and leads to decreased iron export.
Loss of Cp activity prevents Fpn‐mediated iron export
We examined the requirement of Cp for Fpn function in C6 glioma cells, which express a glycosylphosphatidylinositol (GPI)‐linked Cp (Patel and David, 1997). Vertebrate genomes contain a single gene for Cp, but cells can synthesize either a secreted form of Cp or a GPI‐linked Cp anchored to the external surface of the plasma membrane. Incubation of C6 glioma cells with the copper chelator bathocuproine disulfonate (BCS) prevented expression of Cp on the cell surface and led to a decrease in cellular Cp (Figure 1A). Assay of the media did not show the presence of Cp, indicating that GPI‐apoCp is not cleaved from the cell surface. Our results, which do not distinguish between increased degradation and decreased synthesis of GPI‐Cp in BCS‐treated cells, show that BCS treatment prevents the accumulation of cell surface GPI‐Cp.
Incubation of C6 glioma cells with iron leads to an increase in ferritin (Figure 1B). Upon incubation in iron‐free medium, ferritin levels decrease due to export of iron by Fpn. Incubation of C6 glioma cells with BCS reduced the ability of cells to lower their ferritin levels. The decreased ability to export iron was seen even in BCS‐treated cells transfected with plasmids expressing Fpn‐GFP (Supplementary Figure 1). Addition of copper to BCS‐incubated cells led to loss of ferritin, indicating that BCS‐induced copper depletion was responsible for the high levels of ferritin (data not shown). Transfection of C6 glioma cells with a plasmid containing Fpn‐GFP led to the presence of cell surface Fpn (Figure 1C), whereas in cells incubated with BCS, there was a dramatic decrease in Fpn‐GFP. The effect of BCS was specific for Fpn, as transfection of cells with a plasmid containing Divalent Metal Transporter1 (DMT1‐GFP) led to the expression of DMT1‐GFP regardless of whether BCS was present or not (Figure 1C). These results show that copper deprivation does not affect transfection frequency or expression from the CMV promoter.
To confirm the requirement of Cp for cell surface localization of Fpn, we examined the effect of silencing GPI‐Cp. Transfection of C6 glioma cells with RNAi oligonucleotide pools specific for GPI‐Cp led to decreased levels of GPI‐Cp (Figure 2A) but did not affect accumulation of ferritin, when cells were incubated with iron (Figure 2B, left panel). Cells silenced for GPI‐Cp did not decrease ferritin to the levels seen in control cells, when iron‐loaded cells were incubated in iron‐free medium (Figure 2B, right panel). When GPI‐Cp‐silenced cells were transfected with an Fpn‐GFP plasmid, there was no expression of Fpn on the cell surface or within cells (Figure 2C), while transfection with a plasmid containing DMT1‐GFP lead to abundant expression of endosomal DMT1‐GFP, both in GPI‐Cp‐silenced cells and in cells transfected with nonspecific oligonucleotide pools. C6 glioma cells were isolated from a glial tumor and the cells have been maintained in culture for years. The loss of Cp also affects Fpn expression in primary cells. Astrocytes isolated from wild‐type mice have cell surface Fpn, whereas astrocytes isolated from homozygous Cp−/− mice have no detectable Fpn on the cell surface (Figure 2D). Bone marrow macrophages also express GPI‐Cp. A similar failure to localize Fpn on the cell surface was seen in BCS‐treated bone marrow macrophages transfected with an Fpn‐GFP plasmid (Supplementary Figure 2). These results indicate that the absence of Cp leads to the loss of cell surface Fpn in primary as well as cultured cell types. The loss of Fpn due to the absence of Cp is however cell type dependent. HEK293 cells do not express Cp, and in the absence of serum, both endogenous Fpn and transfected Fpn‐GFP in HEK293 cells showed a reduced ability to export iron, yet there was no degradation of cell surface Fpn‐GFP (Supplementary Figures 3 and 4). These results suggest that the Cp‐dependent loss of Fpn may be restricted to cell types that synthesize Cp or GPI‐Cp.
To confirm that loss of expression of Fpn was due to the absence of GPI‐Cp, C6 glioma cells silenced for GPI‐Cp were transfected with a plasmid that contained secreted human Cp under the control of the CMV promoter. This construct was not affected by the silencing oligonucleotide pools, which are specific for rat GPI‐Cp. Cells silenced for rat GPI‐Cp, transfected with the secreted human Cp, showed cell surface Fpn‐GFP (Figure 2E). Transfection of cells with a membrane‐bound multicopper oxidase hephaestin also resulted in the accumulation of Fpn‐GFP on the surface of GPI‐Cp‐silenced cells (data not shown). These results show that the loss of cell surface Fpn‐GFP can be rescued by multicopper oxidases, although there appears to be little specificity in the multicopper oxidase, as both secreted and membrane‐bound multicopper oxidases can restore cell surface Fpn‐GFP.
The absence of Cp increases the internalization of Fpn
We determined that Fpn does not accumulate on the cell surface in the absence of multicopper oxidases, because it is rapidly internalized and degraded. This was shown through the use of mutant dynamin. Dynamin is a GTPase required for the internalization of coated pits and caveolae (Damke et al, 1994). Transfection of cells with a wild type dynamin had no effect on the loss of expression of Fpn‐FLAG in cells silenced for GPI‐Cp (Figure 3A). Expression of a mutant dynamin(K44A) that is unable to hydrolyze GTP leads to an inhibition in membrane internalization. Expression of dynamin(K44A)‐GFP in cells silenced for GPI‐Cp led to accumulation of Fpn‐FLAG on the cell surface. This result demonstrates that the presence of GPI‐Cp stabilizes Fpn‐FLAG on the cell surface. While GPI‐Cp‐silenced cells transfected with dynamin(K44A)‐GFP had accumulated cell surface Fpn‐FLAG, there was no recovery of GPI‐Cp (data not shown). This result confirms that Fpn‐FLAG does not require simultaneous synthesis of GPI‐Cp for Fpn to accumulate at the cell surface. To determine if Fpn is degraded in the lysosome or by the proteasome, cells silenced for GPI‐Cp were transfected with an Fpn‐GFP containing plasmid. The transfected cells were then incubated in the presence or absence of the lysosome inhibitor chloroquine or the proteosomal inhibitor MG132. Cells incubated with chloroquine showed levels of Fpn similar to non‐silenced cells, whereas MG132‐treated cells showed decreased amounts of Fpn (Figure 3B). These data indicate that once internalized, Fpn is degraded in the lysosome.
Addition of multicopper oxidases to Cp‐deficient cells restores cell surface Fpn
Iron transport can be promoted in astrocytes obtained from Cp‐deficient mice by the addition of Cp to the medium (Jeong and David, 2003). Addition of exogenous Cp led to expression of Fpn‐GFP on the surface of C6 cells that were silenced for GPI‐Cp, suggesting that formation of an Fpn–Cp complex in the secretory apparatus is not required for Fpn to accumulate on the cell surface (Figure 4A). An active multicopper oxidase is required for Fpn to accumulate at the cell surface, as addition of human Cp that had been treated with azide to inactivate catalytic activity did not lead to Fpn accumulation (data not shown). Fet3p is a cell surface multicopper oxidase found in fungi, and there is little structural homology between Cp and Fet3p, apart from the amino acids that ligate copper (Askwith et al, 1994). A secreted form of Fet3p, injected into aceruloplasminemic mice, can induce tissue iron release (Harris et al, 2004). Similarly, addition of secreted Fet3p to C6 glioma cells silenced for GPI‐Cp led to the accumulation of cell surface Fpn‐GFP (Figure 3A).
Ferroxidases prevent Fpn internalization by lowering extracellular Fe(II)
We next determined how Cp stabilizes Fpn on the cell surface. Previous work showed that GPI‐Cp and Fpn can be co‐immunoprecipitated (Jeong and David, 2003), suggesting that binding of Cp to Fpn promotes Fpn stability on the cell surface. Co‐immunoprecipitation experiments using C6 glioma cells, however, failed to show any evidence of a complex between transfected Fpn‐GFP and either human secreted Cp or secreted Fet3p (data not shown). It is possible that multicopper oxidases, by promoting iron oxidation, increase iron transport activity and active transport of iron leads to Fpn stabilization on the cell surface. To determine if multicopper oxidases stabilize cell surface Fpn by reducing extracellular Fe(II) concentration, we incubated GPI‐Cp‐silenced C6 glioma cells with bathophenanthroline disulfonate (BPS), an impermeable Fe(II) chelator or desferrioxamine (DFO) conjugated to dextran to ensure that DFO is not permeable. While DFO is an Fe(III) chelator, its affinity for iron is so high (1033) that it alters the Fe(II)/Fe(III) equilibrium and will deplete free Fe(II). Addition of either chelator to GPI‐Cp‐silenced cells led to accumulation of Fpn‐GFP on the cell surface (Figure 4B). This result suggests that the ability of multicopper oxidases to lower extracellular ferrous iron stabilizes Fpn on the cell surface.
Hepcidin, a peptide produced by the liver in response to inflammation and iron stores, regulates iron entry into plasma by binding to Fpn and effecting its internalization and degradation (Nemeth et al, 2004). Hepcidin binding to Fpn induces the phosphorylation of either of two adjacent tyrosine residues (Y302,Y303) (De Domenico et al, 2007). Mutation of both resides to phenylalanine prevents hepcidin‐mediated internalization. Fpn(Y302‐303F)‐GFP, however, is rapidly internalized in GPI‐Cp‐silenced cells (data not shown). This result demonstrates that internalization in the absence of Cp is independent of hepcidin.
Internalization of Fpn in the absence of Cp leads to increased Fpn‐associated iron
We identified two Fpn mutations that are not internalized when expressed in HEK293T cells exposed to hepcidin (De Domenico et al, 2005, 2006a, 2006b). Fpn mutant (N174I) is unable to export iron while Fpn mutant (N144H) is transport competent. Fpn(N144 H)‐GFP expressed in GPI‐Cp silenced C6 glioma cells was not found at the cell surface, whereas Fpn(N174I)‐GFP accumulated at the cell surface (Figure 4C–E). Transport‐incompetent Fpn(N174I)GFP is stable on the cell surface of GPI‐Cp silenced cells while transport‐competent Fpn‐GFP is not stable. This result suggests that some aspect of the transport process, which is not completed in the absence of Cp activity, is responsible for the loss of Fpn.
We considered the possibility that Cp or an Fe chelator affects iron transport by promoting loss of iron from Fpn. We tested this hypothesis by incubating GPI‐Cp‐silenced C6 glioma cells with Tf(59Fe)2 and then examining immunoprecipitated Fpn for 59Fe. There was no detectable immunoprecipitation of 59Fe‐Fpn from cells transfected with nonspecific oligonucleotide pools (Figure 5A, column 1). This is expected, as the retention time of 59Fe in transport‐competent Fpn is likely to be low. There was little 59Fe associated with immunoprecipitated Fpn in GPI‐Cp‐silenced cells, as there is little Fpn (Figure 5A, column 3). There was, however, appreciable 59Fe‐Fpn in GPI‐Cp‐silenced cells expressing dynamin(K44A)‐GFP that traps Fpn on the cell surface (Figure 5A, column 4). No 59Fe was found to be associated with DMT1‐GFP in GPI‐Cp‐silenced cells, indicating that the association of 59Fe with Fpn is not an artifact of immunoprecipitation (data not shown). Addition of Cp or impermeable iron chelators permitted Fpn to accumulate at the cell surface of GPI‐Cp‐silenced cells (Figure 5A, column 5). Similarly, addition of Cp to 59Fe‐labeled GPI‐Cp‐silenced cells expressing dynamin(K44A)‐GFP led to loss of Fpn‐associated 59Fe. No 59Fe was found to be associated with transport‐incompetent Fpn(174I)‐GFP in GPI‐Cp silenced cells (Figure 5B).
We examined if Cp or DFO could promote the loss of iron from 59Fe‐Fpn in cell extracts. Addition of Cp or DFO promoted loss of 59Fe from Fpn, but azide‐inactivated Cp or iron saturated DFO did not effect the loss of 59Fe. These results suggest that the lack of Cp leads to the retention of iron on Fpn (Figure 5C). These data suggest that iron is not irreversibly bound to Fpn.
Internalization of Fpn in the absence of GPI‐Cp results from increased ubiquitination
Transporters are often regulated by their substrates and there is a precedent for transport‐incompetent metal transporters not being degraded (Hettema et al, 2004). Conformational changes that occur during transport may signal degradation by exposing buried residues, which may be recognized by a ubiquitin ligase. Addition of ubiquitin targets the protein for lysosomal degradation. We examined whether Fpn‐FLAG was ubiquitinated in GPI‐Cp‐silenced cells expressing dynaminK44A‐GFP. Little ubiquitin was found on Fpn‐FLAG immunoprecipitated from cells that had been transfected with nonspecific oligonucleotide pools (Figure 6A). The amount of Fpn‐FLAG was decreased in GPI‐Cp‐silenced cells and immunoprecipitated Fpn was ubiquitinated. Fpn was also ubiquitinated in GPI‐Cp‐silenced cells transfected with dynamin K44A‐GFP, which traps Fpn at the cell surface. These results suggest that ubiquitination at the cell surface may lead to Fpn internalization. We previously identified lysine residue K253 in Fpn, which is ubiquitinated following hepcidin‐mediated internalization (De Domenico et al, 2007). Mutation of lysine 253 to alanine resulted in an Fpn that was predominantly on the cell surface in GPI‐Cp‐silenced cells (Figure 6B). (Equivalent immunoprecipitation of Fpn‐GFP represents saturation of antibody.) Western analysis confirmed that Fpn(K253A)‐GFP was not ubiquitinated or degraded. We speculate that transport‐dependent changes in Fpn conformation increase the probability that the K253 will be accessible to an ubiquitin ligase.
Fpn is the only identified iron transporter that exports iron from cells to plasma and as such the presence on cell surface Fpn is the critical feature in regulating plasma iron concentration. In most physiological conditions, the transport of iron by Fpn is regulated by hepcidin, a peptide synthesized by the liver in response to inflammation and hepatic iron load. Hepcidin binds to Fpn and does not inhibit transport activity directly, but rather induces the internalization of Fpn from cell surfaces (Nemeth et al, 2004). Once internalized, Fpn is degraded in the lysosome. The species of iron transported by Fpn is thought to be Fe(II), which is converted to Fe(III) by the multicopper oxidases, ceruloplasmin or hephaestin, which function as ferroxidases. The absence of either multicopper oxidase results in decreased plasma iron and increased iron retention in normally iron exporting cells. Mutations in hephaestin, as seen in the SLA mouse, result primarily in an iron‐limited erythropoiesis (Vulpe et al, 1999). Mutations in ceruloplasmin lead to decreased plasma iron and increased iron retention in a variety of cell types (Harris et al, 1998). Patients with aceruloplasminemia present with adult‐onset neurological disease, retinal degeneration and diabetes mellitus. Massive iron accumulation and extensive loss of neurons are observed in the basal ganglia. The mechanism leading to cellular iron overload has been unclear. Iron may be exported from cells as Fe(II), and a failure to convert that Fe(II) to Fe(III,) due to the lack of Cp loading iron on for transferring, may lead to Fe(II) being accumulated in cells by non‐transferrin transport systems.
In the absence of transferrin, both humans (Hamill et al, 1991) and mice (Bernstein, 1987; Huggenvik et al, 1989) develop a severe anemia due to iron‐limited erythropoiesis. Atransferrinemia also leads to severe iron overload in parenchymal tissues such as liver and pancreas. Yet, atransferrinemic humans or mice do not show evidence of neural or cognitive dysfunction as seen in patients with aceruloplasminemia. This observation suggests a function for Cp independent of its ability to load iron onto transferrin. Here, we demonstrate that Cp is responsible for generating an iron gradient, leading to the loss of Fpn‐bound iron (Figure 6C). In the absence of Cp, iron bound to Fpn results in Fpn internalization. Thus, removal of Fpn‐bound iron is an essential function of Cp, and by extension hephaestin. The conclusion that Cp lowers Fe(II) bound to Fpn is supported by the finding that impermeable iron chelators can lead to the cell surface expression of Fpn in the absence of Cp. This observation indicates that in addition to generating iron bound to transferrin, Cp is required to lower extracellular Fe(II) concentration. Reduced extracellular Fe(II) may create a gradient driving Fpn‐mediated iron transport and in the process, remove iron bound to Fpn. In the absence of that gradient, iron bound to Fpn increases the probability that Fpn will be internalized and degraded.
Mutation of residue Fpn K253 prevents ubiquitination and internalization, maintaining Fpn on the cell surface in Cp‐negative cells. We hypothesize that an E3‐ubiquitin ligase recognizes a conformational state of Fpn resulting from the presence of bound iron. This conformation state might reflect an intermediate in the transport process (Figure 6C). As suggested by Pelham and co‐workers, conformational changes in a transporter due to transporter activity might be expected to lead to perturbation of lipid bilayer, or exposure or normally lipid buried amino‐acid residues in the aqueous cytosol (Hettema et al, 2004). These altered conformations might be recognized by a ubiquitin ligase, leading to decreased transporter degradation. Under normal transport conditions, the probability of that altered conformation being recognized by the ubiquitin ligase might be low, but would increase with extended transport activity. Continued transport activity would lead to a shorter transporter half‐life. Studies with a number of yeast metal transporters have shown that increased transport leads to an increased rate of internalization and degradation (Gitan and Eide, 2000; Hettema et al, 2004; Felice et al, 2005). Internalization and degradation result from the addition of ubiquitin to the transporter. Mutations in the transporter that prevent substrate transport prevent both ubiquitination and degradation.
The requirement for an external ferroxidase to maintain surface Fpn is cell type dependent and appears specific to cells that express GPI‐Cp. Transfected Fpn is stable in the absence of a ferroxidase in a variety of cultured cells (HeLa, HEK293, FMA3) that do not express GPI‐Cp. Fpn is not internalized in the absence of Cp but iron transport activity is reduced. This observation suggests that even in these cell types the ferroxidase activity of Cp promotes iron transport. We speculate that the expression of the specific E3 ligase, which recognizes the altered Fpn conformation, is restricted to those cell types that express GPI‐Cp. That there is a specific E3 ligase is suggested by the observation that hepcidin‐induced Fpn internalization can occur in all (tested) cultured mammalian cells. Once internalized, Fpn is ubiquitinated on K253 and ubiquitination is required for degradation. Mutation of K253 does not prevent hepcidin‐meditated internalization, but prevents the entry of internalized Fpn into the multivesicular body. This result implies that all cells are capable of ubiquitinating Fpn once it is internalized, but that only GPI‐Cp producing cells are capable of recognizing the iron‐bound form of cell surface Fpn.
The results reported here suggest that Fpn internalization may be regulated by factors other than hepcidin. Fpn levels in astrocytes and glioma cells are particularly affected by the loss of GPI‐Cp and this may contribute to the excessive iron overload in the brain seen in aceruloplasminemia. In the absence of endogenous GPI‐Cp, external ferroxidase(s) can promote retention of Fpn on cell surface, leading to cellular iron export. This observation suggests that iron chelation therapy for aceruloplasminemia may decrease cellular iron burden by increasing the expression of Fpn.
Materials and methods
Cells and media
Rat C6 glioma cells were maintained in Dulbecco's minimal essential media (DMEM) with 10% fetal bovine serum. Mouse bone marrow macrophages, isolated from mouse femurs, were grown in RPMI 1640 with 20% equine serum for 6 days and adherent cells were further cultured in RPMI 1640 with 20% fetal bovine serum and 30% L cell‐conditioned medium. Cells were iron loaded by addition of FAC (10 μM iron) for 18 h.
Transient transfection
All mouse Fpn‐GFP constructs (wild type or mutant) or Fpn‐FLAG were generated as previously described (De Domenico et al, 2005), and pDynamin‐EGFP, pDynaminK44A‐EGFP (a generous gift from Dr Matt Mulvey), pDMT1‐EGFP‐C1 (a generous gift from Dr Hiroshi Gunshin) or pCMV‐Tag4b‐FLAG‐HsecretedCp were transfected using Nucleofector technology (Amaxa, Gaithersburg, MD), according to the manufacturer's instructions.
siRNA transfection
siRNA oligonucleotide pools, nonspecific and rat GPI‐Cp specific, were obtained from Dharmacon. C6 cells were transfected using Oligofectamine reagent (Invitrogen), with siRNAs at a final concentration of 100 nM. Eighteen hours post‐transfection, cells were trypsinized and plated onto 60‐mm plates. Eighteen hours after plating, cells were transfected with pFpn‐EGFP‐N1, pCMV‐Fpn‐FLAG, pDynamin‐EGFP, pDynaminK44A‐EGFP, pDMT1‐EGFP‐C1 or pCMV‐Tag4b‐FLAG‐HsecretedCp, using the Nucleofector. Cells were grown for 18–24 h and then processed for immunofluorescence microscopy, Western blot analysis or incubated with FAC for 18 h before determining ferritin levels.
Other procedures
Cells were solubilized in 1.0% Triton X‐100, 150 mM NaCl, 10 mM EDTA and 10 mM Tris, pH 7.4 with a protease inhibitor cocktail (Roche). Fpn‐GFP was immunoprecipitated using rabbit anti‐GFP (1:1000, Abcam) and protein A/G Agarose at 4°C overnight. Fpn‐FLAG was immunoprecipitated using FLAG beads (Sigma) at 4°C overnight. Total protein concentrations were determined using BCA reagent (Pierce). Protein samples were separated on 4–20% gels (Tris–Glycine) (BioRad) and transferred in Hybond‐ECL (Amersham Biosciences). Western analysis was performed using goat anti‐Cp antibody (1:1000, Sigma), goat anti‐actin (1:1000, Santa Cruz), rabbit anti‐GFP (1:10 000, Abcam #ab6556), goat anti‐tubulin (1:1000, Gene Tex) or mouse anti‐ubiquitin (1:1000, Covance), followed by treatment with peroxidase‐conjugated goat anti‐rabbit IgG (1:10 000, Jackson ImmunoResearch Labs) and peroxidase‐conjugated goat anti‐mouse IgG (1:10 000, Jackson ImmunoResearch Labs), or peroxidase‐conjugated donkey anti‐goat IgG (1:5000, Santa Cruz Biotechnology). Immunofluorescence was performed as described previously (De Domenico et al, 2005), in non‐permeabilized cells, using either donkey anti‐Cp antibody (1:100, Abcam) or mouse anti‐FLAG antibody (1:750, Sigma), followed by treatment with Alexa 594‐conjugated goat anti‐donkey IgG (1:750, Molecular Probes) or Alexa 594‐conjugated goat anti‐mouse IgG (1:750, Molecular Probes) as the secondary antibody. Astrocyte immunofluorescence was performed using astrocytes purified from dissociated cell cultures of the neonatal mouse cerebral cortex from Cp−/− and Cp+/+ mice, as described previously (Jeong and David, 2003). Cells were plated on poly‐l‐lysine‐coated round glass coverslips and cultured in DMEM containing 10% fetal bovine serum. Cells were washed in Hank's balanced salt solution (HBSS) and live cultures incubated with anti‐FPN1 polyclonal antibody (1:100, Alpha Diagnostics) for 30 min at room temperature. Cells were washed, and then incubated with Alexa‐Fluor 488‐conjugated goat anti‐rabbit IgG (1:200, Molecular Probes) for 30 min. Cells were fixed and permeabilized in acetic acid/ethanol (5:95 (v/v)) at −20°C for 20 min. Cells were then incubated with a monoclonal anti‐glial fibrillary acidic protein (GFAP, an astrocyte marker, 1:100, Zymed Laboratories) for 30 min at room temperature and visualized with a rhodamine‐conjugated goat anti‐rat IgG (1:200, Jackson Immunoresearch). Nuclei were labeled with 100 ng/ml 4′‐6‐diamidino‐2‐phenylindole (DAPI, Vector Laboratories) and viewed with a Zeiss Axioskop 2 plus microscope. MG132 and chloroquine (Sigma) were used as described previously (De Domenico et al, 2006a, 2006b). DFO‐dextran was a generous gift from Dr Bo Hedland (Biomedical Frontiers). Ferritin analysis was performed as described (De Domenico et al, 2005). Human apo‐Tf was iron loaded as described previously (Nemeth et al, 2004). Human ceruloplasmin (Sigma) was inactivated by incubation with 100 μM azide and then extensively dialyzed against PBS before use.
Supplementary data
Supplementary data are available at The EMBO Journal Online (http://www.embojournal.org).
Supplementary Information
Supplementary Figure 1 [emboj7601735-sup-0001.tiff]
Supplementary Figure 2 [emboj7601735-sup-0002.tiff]
Supplementary Figure 3 [emboj7601735-sup-0003.tiff]
Supplementary Figure 4 [emboj7601735-sup-0004.tiff]
Legend to Supplementary Figures [emboj7601735-sup-0005.doc]
We thank Dr JP Kushner for help in preparing the manuscript and Dr J Gitlin for useful conversations. This work was supported by a grant from the NIH DK079047 to JK and a grant from the Canadian Institutes of Health Research to SD and a Center of Excellence in Hematology Award (NIH CA43014). The financial support of Telethon‐Italy GGP06173 to GM is gratefully acknowledged.
- Copyright © 2007 European Molecular Biology Organization


text:
Regina Dawn Akers guides a group of committed students who would like to make consistent, gentle progress toward genuine peace, joy and love. This group meets weekly and all members are committed to specific assignments and practices between group meetings. Everyone who is willing to make a commitment to healing/awakening is invited to join this group.
Homework for the upcoming week:
Homework Assignment A: Workbook lessons 153-159. Practice daily awareness-watching-awareness meditation for 15-20 minutes each day. Practice the "Loving All" Method.
Homework Assignment B: Watch the movie, 'Little Buddha.' You will find it in the The Gentle Healing Playlist.


text:
What does DBDB stand for?
DBDB stands for Digital Bathymetric Database (US DoD)
This definition appears very rarely and is found in the following Acronym Finder categories:
- Military and Government
- Science, medicine, engineering, etc.
See other definitions of DBDB
Other Resources:
We have 1 other meaning of DBDB in our Acronym Attic
- Abbreviation Database Surfer
- « Previous
- Next »
- Death Before Dishonor 2 (gaming)
- Data Base Design Aid
- David Bailey Design + Advertising
- Dawn Boyfield Design Associates (UK)
- Day by Day Armageddon (zombie fiction)
- Design Basis Depressurization Accident
- Downtown Boone Development Association
- 1,4-Di-T-Butyl-1,4-Diazabutadiene (paramagnetic aluminium)
- Drifting Buoy Data Assembly Center
- DNA Barcode Data Analysis Initiative
- Don't Be a Douchebag
- Du Bruit dans le Bourg (French: Noise in the Village)
- Digital Bathymetric Data Base - Variable resolution
- Digital Bathymetric Data Base-5 Minute
- Digital Bathymetric Data Base - Variable Resolution
- Defence Business Development Consulting (Belgium)
- Des Bruits de Casseroles (French: Sound of Pots)
- Distal Bile Duct Carcinoma
- Double Barrel Design Consultancy (London, England, UK)
- Double-Bounded Dichotomous Choice


text:
Contractors' confidence sinks to near record low
Driven by Brexit and government policy, the confidence of the UK's two million contractors has fallen to the second lowest level on record, says IPSE.
The contracting trade body found its members to be the least optimistic since the second quarter of last year, and their outlook has generally remained in negative territory since.
"This indicates that freelancers continue to expect a medium-term decline in their business performance," said the Association of Independent Professionals and the Self-Employed (IPSE).
In human terms, the index means that fewer than one in three contractors between January and March had "confidence" in their business performance for the subsequent 12 months.
And it means that the confidence in their prospects over the same period has abated among four in 10 of them, in line with most of the contractors also having a bleaker three-month outlook.
The only bright spot, it seems, is that confidence in their own one-person business -- despite being at a near record low, is still higher than their confidence in the economy.
This is despite the "relatively strong performance" of the economy since Brexit, which itself is serving to sap freelancer' confidence.
"Alongside Brexit, those surveyed listed government policy as one of the two primary causes for their downturn in confidence," added IPSE's chief executive Chris Bryce, who described the findings as 'concerning.'
"Maintaining the current rate of NICs, simplifying the over-complicated new Making Tax Digital rules and giving greater powers to the small business commissioner would go a long way to alleviating their frail confidence levels."
Contractor's Question
If you have a question about contracting please feel free to ask us!


text:
The public is invited to a free event from 2 pm to 4 pm on Saturday, October 26 celebrating the Battle of Ridgeway, at the Battle of Ridgeway Park, 3388 Garrison Road, Ridgeway.
Back in 1866, all eyes were on Ridgeway and Fort Erie Museum Services brings a new look to the Battle of Ridgeway through an dynamic exhibit located right on the battlefield. This exhibit traces the origin of the conflict to its result – the creation of Canada.
Visitors to the battlefield will gain insight into what happened and appreciate the sacrifices made here almost 150 years ago.
To mark this occasion the museum is hosting a free, special event on October 26 from 2-4 p.m. at the battlefield Activities for all ages will provide a hands-on look at 1866. A working telegraph will demonstrate
the power of instant messaging. Participants can try their hand at being a
war artist, like Alexander Von Erichsen who followed the Fenians and painted the invasion. Many of his watercolour images from the museum collection are included in the exhibit. Members of the Queen's Own
Rifles and the Welland Field Artillery will be on site.
Museum Administrator Jane Davies acknowledged that this exhibit was made possible through the generous support of the Bertie Historical Society,Farm Credit Canada, donations in memory of Victor Miller, Fort Erie Bingo, and the Capern family. Davies noted that the national spotlight will be focused on Ridgeway with the 150th anniversary of confederation fast approaching. The events on this battleground played an important role in the formation of our country.
Local visitors to the park have enjoyed seeing the exhibit installed over the month of September. Museum Board Chair Charlie Capern said "This should help people to realize what this park is actually about
and we will be all be that much richer for understanding our local heritage."
There will be a souvenir shop associated with this event along with the sights and sounds of 1866.
Bring your camera and capture all the action. Public parking will be available at All Nations Church at 3397 Garrison Road across from the battlefield.
*for further information from the Greater Fort Erie Chamber of Commerce visit www.FortErieChamber.com


text:
Angular Core Dependency: 1.2.0-rc.1
Added by: Sam Deering
Stars: 138
Watchers: 138
Forks: 32
I don't have much time to work on this project and I no longer use it for anything.
I'd love it if I could work with somebody to get v1.0.0 out the door. I have refactors, bug fixes, and new tests in the pipeline, but there's more work to do.
If any user of this library wants to assist me, I'll happily answer any questions, provide tasks, and discuss direction.
Once we release v1.0.0, I could potentially transfer ownership of this project to another collaborator.
Please comment in issue #48 if you are interested!
Pure AngularJS tagging widget with typeahead support courtesy of ui-bootstrap.
bower install angular-tags
Clone this repo and execute:
npm install
to grab the dependencies. Then execute:
grunt test
to run the tests. This will grab the test deps from bower, and run them against QUnit in a local server on port 8000.
angular-tags comes in two versions; one with embedded templates and another without. Without templates:
<script src="/path/to/angular-tags-VERSION.js"></script>
With templates:
<script src="/path/to/angular-tags-VERSION-tpls.js"></script>
You will also want to include the CSS if you are using this version:
<link rel="stylesheet" href="/path/to/angular-tags-VERSION.css"/>
Templates are included in the
templates/ directory if you want to load them manually and/or modify them.
You'll also need to make sure you have included the ui-bootstrap source.
Finally, include the module in your code, and the required
ui.bootstrap.typeahead module:
angular.module('myModule', ['decipher.tags', 'ui.bootstrap.typeahead'];
This is a directive, so at its most basic:
<tags model="foo"></tags>
This will render the tags contained in
foo (if anything) and provide an input prompt for more tags.
foo can be a delimited string, array of strings, or array of objects with
name properties:
foo = 'foo,bar';
foo = ['foo', 'bar'];
foo = [{name: 'foo'}, {name: 'bar'}];
All will render identically. Depending on the format you use, you will get the same type back when adding tags via the input. For example, if you add "baz" in the input and your original model happened to be a delimited string, you will get:
Likewise if you had an array of strings:
['foo', 'bar', 'baz']
The above directive usage will not use the typeahead functionality of ui-bootstrap. To use the typehead functionality, which provides a list of tags from which to choose, you have to specify some values to read from:
<tags model="foo" src="b as b.name for b in baz"></tags>
The value of
src is a comprehension expression, like found in ngOptions.
baz here should resemble
foo as above; a delimited string, an array of strings, or an array of objects. See Tag Objects below.
Note: Here we're using
b (the entire object) for the value; feel free to use something else, but if we use
b, the directive will retain any extra data you have put in the tag objects:
baz = [
{foo: 'bar', value: 'baz', name: 'derp'},
{foo: 'spam', value: 'baz', name: 'herp'},
<tags model="foo" src="b.value as b.name for b in baz"></tags>
The resulting source tags will look like this:
baz = [
{value: 'baz', name: 'derp'},
{value: 'baz', name: 'herp'},
Basically, whatever you set here will become the
value of these tags unless you specify an entire object.
You can pass options through to the typeahead module. Simply pass a
typeahead-options attribute to the
<tags> element. Available options are shown here:
$scope.typeaheadOpts = {
inputFormatter: myInputFormatterFunction,
loading: myLoadingBoolean,
minLength: 3,
onSelect: myOnSelectFunction, // this will be run in addition to directive internals
templateUrl: '/path/to/my/template.html',
waitMs: 500,
allowsEditable: true
<tags typeahead-options="typeaheadOpts" model="foo" src="b.value as b.name for b in baz"></tags>
Tag objects have three main properties:
name The name (display name) of the tag
group (optional) The "group" of the tag, for assigning class names
value (optional) The "value" of the tag, which is not displayed
Tag objects can include any other properties you wish to add.
To set defaults module-wide, inject the
decipherTagsOptions constant into anything and modify it:
myModule.config(function(decipherTagsOptions) {
decipherTagsOptions.delimiter = ':';
decipherTagsOptions.classes = {
myGroup: 'myClass',
myOtherGroup: 'myOtherClass'
addable whether or not the user is allowed to type arbitrary tags into the input (defaults to
false by default if a
src is supplied, otherwise defaults to
true; see Adding Tags below.
delimiter what to use for a delimiter when typing or pasting into the input. Defaults to
classes An object mapping of group names to class names
templateUrl URL to the main template. Defaults to
tagTemplateUrl URL to the "tag" template. Defaults to
If you neglect to supply a
src (thus not using typeahead) you will be able to enter whatever you like into the tags input, adding tags willy-nilly. If you do supply a
src, by default the user will be limited to what's in the list. You can override this by passing an
addable property to the options:
<tags options="{addable: true}" model="foo" src="b as b.name for b in baz"></tags>
If you specify classes, your tags will each be assigned a class name based on the group. For example:
<tags options="{classes: {myGroup: 'myClass'}}" model="foo" src="b as b.name for b in baz></tags>
Now when a tag is added to the list, and that tag has the
group of
myGroup, it will receive the
myClass class. This is useful if you want to change the color of certain tags or something.
The directive will emit certain events based on what's going on:
decipher.tags.initialized: Emitted when the directive is linked. Data will include a unique
$id value of the directive and the original
model value.
decipher.tags.keyup: Emitted when the user types something into the input. Data will include the unique
$id and the
value, which is what the user has typed so far. You can attach to this to do validation or anything else.
decipher.tags.added: Emitted when the user has successfully added a tag. Data will include the unique
$id and a
tag object representing the tag added.
decipher.tags.addfailed: Emitted when the user tries to add a tag that is not available for whatever reason. This will occur if the user attempts to add a duplicate tag, or if they attempt to add a tag that is not in the supplied
src list. Data will include the unique
$id and a
tag object representing the tag that failed to be added.
decipher.tags.removed: Emitted when the user removes a tag, either via backspacing or clicking on the little
x in the tag. Data will include the unique
$id and a
tag object representing the tag removed.
Carl Dougan (@carlsgit) and Christopher Hiller (@boneskull)
Module stats last updated: 2018-01-12 15:00:07
Disclaimer: Some data on this page may have been gathered from the authors GitHub respository. If you see any mistakes or outdated information please let us know. Thanks!


text:
Excellent carrier! Great for newborns and young infants. My baby loved it and always fell asleep in it. Comfy to wear, and super easy to put on, like a tshirt with the comfort of a moby or kangaroo wrap. Totally reccommend it. Watch the sizing, I am 5'0" and 100lbs and the size small fit me perfectly.
Perfect baby carrier to wear around the house! I find it very comfortable and my daughter loves it!
These reviews are the subjective opinions of ChickAdvisor members and not of ChickAdvisor Inc.


text:
Wedding Minister in and around La Jara, New Mexico.
Life's Moments are those times in life that we choose to make a special acknowledgment of life altering occasions. Weddings are celebrations, weddings are events, yet most of all weddings are a new beginning, a minute in time to be treasured. Having the best Minister is very important.
For these moments, we offer thorough Wedding Minister solutions, Justice Of The Peace Wedding officiating, and wedding event services. From the very traditional to contemporary services, our wedding celebrations and officiating solutions are designed to show your wants, dreams and needs. We can assist you to craft an occasion, nonreligious or spiritual that will be a valued memory for many years to come.
Ministerial solutions and wedding celebration officiating in the La Jara, New Mexico area is our specialty, yet we could travel if the requirement arises. We give a full range of Justice Of The Peace Wedding plans; from elopement on the courthouse steps to the most elaborate formal wedding you might want.
We also offer the finest in Justice of the Peace or secular weddings. These civil ceremonies provide their very own form of celebration, whether it be with family or simply a couple as well as a couple of witnesses, your wedding event is an unique moment to be valued.


text: Seller: matzoll (1,371) 100%, Location: Waterford, Michigan, Ships to: US & many other countries, Item: 252646562781 Lot of 2 Antique Brass Dresser Back Plates For Pulls-No Eye Bolts No Pulls-H0126 Nice heavy brass dresser back plates for pulls need cleaning. Non Magnetic. Missing eye bolts and pulls. Wear appropriate for age. No dents or deep scratches/marks. Looks like blue paint that has worn mostly off over time. Measurements: Back Plate: 3 7/8 L x 1 3/8 W Protrusion: 1/16 Holes: 3 on center All items are sold as is as found with no warranties expressed or implied. Please look at the pics closely as they are an integral part of my description. All questions welcome as something important to you I may not have mentioned. Please ask questions before bidding/buying. YES! I do combine shipping on compatible items. Send me a message on multiple purchases and I will refund the over payment on shipping once packaged. Hey! Thanks for looking! Check out my other items ... You never know what you might find! Condition: Need cleaning. No cracks or breaks. Missing eye bolts and pulls. Looks to have been painted blue which most of has been lost over time., Color: Blue paint loss, Material: Brass


text:
NY Tower Developer Wins Approval For Bankruptcy Exit Plan
Following an hour-long hearing, U.S. Bankruptcy Judge Stuart M. Bernstein confirmed the amended plan, which was filed just Tuesday, after making minor changes.
Under the plan, First Manhattan will receive the glass-clad condominium that it had held as security for a note purchased from...
To view the full article, register now.
Try Law360 FREE for seven days
Already a subscriber? Click here to login


text:
Campaign launched to reduce gum waste in Limerick
A MAJOR awareness campaign has been launched in an effort to reduce the amount of chewing gum being dumped on city streets.
The local campaign, which was launched by the Mayor of Limerick, Cllr Gerry McLoughlin, aims to reduce gum litter by raising public awareness that dropping gum on the ground is a littering offence which attracts a €150 on-the-spot fine.
Last year, the Gum Litter Taskforce (GLT) campaign achieved a 28% reduction in gum litter nationally.
"It is heartening to see local authorities, industry and the general public working together to make a tangible difference to Limerick city streets," said Mayor McLoughlin at the Limerick launch of this year's campaign.
James Ryan of the Limerick city Tidy Towns committee, which is supporting the campaign is calling on the public to support the campaign.
"I would like to encourage everyone to get behind this campaign. Bin your gum litter and keep our City streets clean."
The theme of the campaign is "Bin It Your Way" and it features a series of professionally choreographed and highly innovative dance moves which communicate the responsible disposal of gum litter in an engaging way.
For more information, log onto gumlittertaskforce.ie


text:
March 3, 2009
It was an escape.
No two ways about it, what happened Saturday between Georgetown and Villanova was not a pretty game of basketball. The teams combined for 40-plus turnovers, with the Hoyas supplying 25. With the score 52-50 with five minutes remaining, you'd expect a tight finish. What you wouldn't expect is that four minutes and about fifteen possessions later, you'd be looking at the exact same score. But when the defensive slugfest came to an end, the Hoyas were 56-54 victors. And, fittingly, for all the complaining by Villanova fans about last year's game—when Corey Stokes was called for a bump on Jon Wallace 80 feet from the basket with 0.1 second remaining in a tied game—this year, they would have been desperate to foul the Georgetown point guard as he pushed the ball up the sideline.
While the debate over the merits of 07-08 Jon Wallace vs. 08-09 Chris Wright as the Hoyas' main facilitator continues, one common theme is that Chris shows a second gear that the walkon from Alabama never had. And it showed Saturday afternoon.
With 3.5 seconds left on the clock, Chris did what needed to be done. He escaped.
And with that the Hoyas got out of Wachovia with a surprising win. And maybe started their own Great Escape.
As a current senior whose Georgetown basketball historical frame of reference is the last three seasons, this year has been a little hard to wrap my head around. Based off previous years, I—and probably the rest of the Class of 2009—figured a Sweet Sixteen was a nice bar to set for the season, challenging for the Big East regular season or Tournament championships a reasonable expectation, and an NCAA Tournament berth a given.
Now that's all been thrown out the window, I'm trying to find a decent corollary to explain this year. The best one I can think of is—wait for it—Fulham F.C.'s 2007-2008 season in the English Premier League. Entering the last month of the season, the Cottagers had taken only 24 points from 33 matches, managing only four wins and enduring a 12-match winless streak. Relegation to the lower-level Championship was a mathematical near-certainty. And yet, over five weeks, Fulham put together four wins, three away from home, and when Danny Murphy headed home a 76th-minute winner at Portsmouth, Fulham managed to stay up in the Premiership for another season (and probably earned themselves another $60 million in TV revenue, but that's neither here nor there.)
The Great Escape, as the season has come to be known, is not only evidence of the excitement throughout the league when the prospects of being relegated are just as pressing as those of winning a championship—although that's a discussion for another forum—but proof that on occasion, a team can reverse a bad stretch, grit out a victory (in each victory, the game-winner was scored in the last 15 minutes), and make it back to their rightful spot: the Premier League, or the NCAA Tournament.
One further corollary: Over the course of the five-week stretch, had Fulham started Carlos Bocanegra instead of leaving him on the bench, they would have had four Americans in the starting lineup, just like the Hoyas.
We're not there yet. There are a number of things that still must be fixed in the Hoyas' remaining two games against St. John's and DePaul. But Saturday afternoon, as we left Wachovia to board the buses back to D.C., visions of turnovers and Wildcat trips to the free-throw line still swirling in my head, only one thing really mattered:
We escaped.
Hoya Saxa,
Paul Campbell (MSB 09)
Generation Roy


text:
It's been six years, but Seattle TV station KIRO 7 still hasn't gotten over the SuperSonics' move to Oklahoma City to become the Thunder. In protest of this fait accompli, they've resolved never to say the words "Oklahoma City Thunder," and instead are only referring to the team as the Former SuperSonics.
Also on Extra Mustard: Kyle Lowry Brings His Son to a Press Conference, Cuteness Ensues
According to KIRO 7's Facebook page, "The former Seattle SuperSonics are in the NBA playoffs. Throughout their run, KIRO 7 promises you we won't say OKC or their team name in our newscasts."
Look, I get it, Seattle. Breakups are always hard. But you need to move on. Show the Thunder that you don't need them anymore. When you bump into the Thunder at the supermarket, you don't want to come off as desperate and clingy, you know? So get out there, take some classes, maybe finish your novel. And then, when the time is right, a new basketball team will come into your life, and you two can ride off into the sunset together.
Follow Extra Mustard and Nicole Conlan on Twitter.


text:
User summary:
Presents a vampire spawn template, a vampire spawn prestige class, a vampire template, and a vampire prestige class. These allow any creature to be turned into a vampire using the standard game rules and the templates. Creatures thus changed can then be advanced to significant power levels by using the prestige classes.


text:
Thieves have stolen a white twin-axle box trailer Boston Road Industrial Estate in Horncastle.
The theft took place on the afternoon of Tuesday, December 31. The trailer was bearing the registration plate 4 RSM. It had a large picture of a skip lorry and crane on the side. The trailer was fitted with a crane and was virtually brand new.
Police enquiries have revealed that the trailer was removed by a white car-derived van, possibly a Vauxhall.
If you see the trailer or registration plate (as it may have been removed and discarded), please call 101 quoting incident 262 31/12/13.
PC Andrew Price said: "Please may I use this opportunity to advise all trailer owners to keep them secure and ensure that the serial numbers are recorded.
"Having a photograph available is also useful in case it is ever stolen. As usual, please report any suspicious persons/vehicles via 101 or 999 as appropriate.
"If you need any crime reduction advice, please contact 101 and ask for your local Neighbourhood Policing Team."


text:
Cotswolds Gin
A new premium Gin and also Premium Vodka is being sold by the Cotswold Brewing Company. Oozing with a premium quality taste, it sits deservingly alongside their range of Cotswold lagers and Beers.
Inspired from the beauty of the Cotswolds this can be seen as an ideal gift for friends or to sit and relax at the end of a hard day.
Cotswold Brewing are based in Bourton on the Water and a very popular brewing company amongst many of the local pubs and restaurants.
The new Cotswolds Gin and Cotswolds Vodka will add to their already growing range of products.
Both of the products are now available to purchase online.


text:
Savannah State Women's Basketball Individual Camp, June 23-27 at Wilcox Gymnasium on SSU campus. For ages 7-17, 8 a.m. to 4 p.m. Fundamentals will be taught by SSU staff, including head coach Cedric Baker. Academic counseling and health-related issues will also be targeted. Campers will receive a free T-shirt and basketball. Fee: $65. Contact: Julie Johnson at 353-2386 or 478-494-1751.
Registration for middle school, high school girls and boys summer basketball, Islands YMCA. Team registration continues through June 30. Games will run July 7-Aug. 4. Divisions are: middle school, 12-13 years old; junior varsity, 14-15; varsity, 15-18. Birth certificates and picture ID required. Fee: $300 per team. Information: 897-1192.
The third annual Summerfest Half-Rubber Tournament, June 21 at the Ambuc Sports Complex. The event is for teams of three to four players. Fee: $30 per player. Check-in is at 8:30 a.m. on the 21st, and the format is four-inning, double-elimination. Entry forms are available at Thompson's Sporting Goods and Russell's Sporting Goods, or online at www.halfrubber.com. Contact: Paul Redmond at 272-3562.
Liberty County Recreation Department summer programs: day camp, swim lessons, swim team, sports camps, tae kwon do, golf, tennis, track and field, and weight training. Registration will be accepted at the LCRD office, which is located in Shuman Recreation Center at James Brown Park, Monday through Friday, from 10 a.m.-6 p.m. Online registration available at www.lcrd.net. Information: 876-5359.
Bulloch Academy in Statesboro will host the Gator FUNdamental football day camp with assistant head coach Ronnie Hodges. The June 16-19 camp is for boys and girls going into grades 2-5. Fee: $75 by June 1, $85 afterward. Campers need to bring cleats and a water bottle. Information: 912-764-0718 or 587-5070.
Kem Dennard and Kim Burnette will run the cheerleading camp for girls going into grades K5 (age 5) to fifth on June 9-12. Fee: $85. Contact: 764-6297.
The BC Sports Camp for children ages 9 and older will focus on the following sports: football I and II, soccer, wrestling, baseball, softball and girls and boys basketball.
The camp is held at Benedictine from 9 a.m. to noon each day in three one-week sessions June 9-13, June 16-20 and June 23-27. Week One football, Week Two baseball and Week Three basketball is for grades 6-9. Fee: $50 for one week, $95 for two weeks and $140 for three weeks. Contact: Tommy Cannon at 644-7003 or firstname.lastname@example.com.
Also at the school is the BC Cheerleading Mini Camp for girls 5 and older. The hours are 9 a.m. to noon on July 21-25. The cost is $75 and includes a T-shirt. Contact: Pam Veiock at 644-7008 or firstname.lastname@example.com.
The Richmond Hill Soccer club invites players from southeast Georgia to tryouts for two Select teams: a girls U-19 and a boys U-13/14 team. Girls tryouts will be Monday at 9 a.m. and the boys tryouts will be June 12-13 from 6:30-8 p.m. All tryouts will be held at Richmond Hill Elementary. Fee: $75 is payable after being selected. Contact: Darrell Snider at 727-2775 or firstname.lastname@example.com for boys team; firstname.lastname@example.com for girls team.
Armstrong Atlantic State will host three soccer camps this summer. Each will be directed by AASU women's soccer coach Eric Faulconer. The 4v4 Skills Camp is set for June 16-20 for boys/girls ages 8-12. The camp will run from 8:30-11:30 a.m. The Finishing/Goalkeeping Camp is scheduled to run June 29-30 for boys/girls 10-18. The camp will run from 8:30 a.m. to 4:30 p.m. Also, the Girls Elite Camp is set for July 20-23 for ages 13-18. The camp will run from 4:30-7:30 p.m. Contact: 344-3095 or e-mail firstname.lastname@example.com.
Select tryouts for U14 and U15 boys and girls, Effingham County Recreation and Parks. The age-control date is Aug. 1, 2008. Tryouts dates: June 10, June 12, June 17 and June 19 from 6:30-8 p.m. at Sand Hill Complex. Players should attend two tryout sessions. A registration form signed by a parent or guardian must be filled out the day of the tryout. Upon notification of making the team, each player must submit a registration fee of $60 to ECRP. Contact: Araya D. Araya at 754-2105, extension 4504.
Coastal Triathlon has weekly Tuesday class at Lake Mayer. Runners train from 5-6 p.m., meeting at the Chatham County Aquatic Center. Swimmers train from 6-7 p.m. Cost: $15 for one session, $55 for four, $90 for eight. Swimming lessons are $50 per hour for one, $74 per hour for two swimmers. Information: firstname.lastname@example.com.


text:
Earn 5 Together Rewards points on this item
Jellyfish Are Disgusting
Format: Paperback Author: Joshua George
Free Click & Collect
Check availability in your local store
Free Delivery Available
- Free Standard over £20
- Standard delivery £2.99
- Next working day £4.99
Product Information
Details:
 Everybody knows turtles eat jellyfish! Well, everyone except a little turtle called Burt who thinks that they are stingy, and stringy and disgusting!

 Join Burt as he travels the ocean making friends...but will his tastes ever change?

 Ideal for:
 A hilarious picture book with wonderful illustrations, a must for little ones.

 This paperback b
Stress-Free Returns
Subject to exceptions, we are happy to exchange or refund your purchase within 28 days of delivery. You can return items by post or to one of our stores.Go to full returns information
Together Rewards
5 points for every pound you spend
Rewards Points PLUS Great Prices - YES! We're proud to give even more back to you and reward all Together Rewards Card members with 5 points for every £1 spent, along with exclusive offers, bonus points promotions, member exclusive gifts and more! Interested? Order a card with your purchase and once you've registered and linked your Card, you'll receive 50 FREE points (worth 50p) and you'll receive Reward Vouchers every 3 months to spend on anything you like in-store and online! Click here to find out how to get your Together Card.


text:
Late Cuban salsa singer Celia Cruz was honored on the Walk of Legends at New York City's Apollo Theater. The "Queen of Salsa" is the first Latin artist to be honored with a place at the Apollo's Walk of Legends.
She was honored on March 22, which marked the 50th anniversary of her first appearance at the legendary New York theater. Cruz performed there in 1964, sharing the now iconic stage with Cuban musician Machito and Puerto Rican musician Joe Cuba. During Saturday's event, Cuban singer Lucrecia and Dominican salsa musician Jose Alberto, known as "El canario," performed some of Cruz's most famous songs, reports Fox News Latino.
Cruz also has a star on the Hollywood Walk of Fame.
PS: I'm absolutely obsessed with Celia! So glad she continues to be recognized for her tremendous contributions to the music business.


text:
Blogging from A to Z Challenge. For those unfamiliar with the concept, it's basically about 26 posts (we don't post Sundays), preferably on a theme, blogging our way through the alphabet from A to Z. My theme this year is all about TV Tropes, celebrating random tropes with some sort of weird, odd, unusual, controversial, or taboo element that appeals to my warped sense of literary adventure.
Continuing the theme, we have Brains and Bondage (check out the page for a complete definition, but your first guess is probably pretty close to the mark). After a quick perusal of the Literature examples provided, I've gotta go with:
"Kushiels Legacy is made of this trope. Terre D'Ange is by and large highly accepting of any sexual kinks, and while there's less talk among the general public about the S&M practices, they're also considered sacred. This view is magnified exponentially by the main character, who experiences pain as pleasure (the mark of her patron god). She is a high class prostitute, and engages in a wide range of masochistic sexual encounters. Many of these are portrayed as loving, cleansing, or just downright fun. The negative BDSM scenes are a result of true malice on the part of her client, and are portrayed as perversions of the kink, rather than the entirety of it. Moreover, Phedre is extremely intelligent, and the books often wax philosophical on the nature of pain, pleasure, and sexuality."
Thursday, April 2, 2015
A to Z Challenge: Brains and Bondage
4 comments:
Pain as pleasure. I never understood that.ReplyDelete
I sort of understand the psychology of it all. Very interesting! It is nice to meet you I am one of Lisa's Live Wires!ReplyDelete
Finally found a few moments to visit my fellow Live Wires! Interesting theme for the challenge. Being a Stephen King, Dean Koontz, Clive Barker, etc. fan, odd, weird and creepy are good. LOL.ReplyDelete
Have a great night! Eva
I am with Alex on this one. I don't even read these kinds of book. Good "B" however, as it's interesting.ReplyDelete
~Rhonda, a fellow LiveWire
Subscribe to: Post Comments (Atom)