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stupid question: why do serum starving? - (Dec/15/2005 )
I know people normally do serum starving before treating the cells with certain enzyme inhibitors. I know that serum starving can cause all cells to enter G0 phase, and I would understand that if serum starving is used in cell cycle studies. However, for treatment of enzyme inhibitors, what is the point of serum starving the cells?
Serum is full of proteins that can inhibit enyme activity, hence why you use a serum-based media to wash cells after trypinising - to deactivate the trypsin.
When studying enzyme activity in cell culture, you want to eliminate the proteins contained in serum that deactivate the normal enzyme activity.
If you are adding enzyme inhibitors and want to see if they work specifically, removing the serum helps you verify that it is the inhibitor and not the serum proteins.
Hope this helps,
we need to synchronize the cells before this kind of experiment...
after O/N starvation, cells are cultured for some minutes (or hours) in normal medium in the presence of not of the inhibitor such as the initial enzymatic activity is null and do not increase significantly if inhibited, in contrary to control conditions in which the activity will reach the maximum in all the cells
we obtain a better shift in inhibition
imagine what append in a population of cells with a broad spectrum of activity: inhibitor will have more troubles to downregulate enzymes with high activity and will be very active on onzymes with low activity... very difficult to observe and to interprete
that's my point of view


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Europe's Morning MoneyBeat: France Falls Into Recession
European stocks are expected to open higher Wednesday, alongside a weaker euro, after the Dow Jones Industrial Average hit another record close on Wall Street and the Nikkei topped the 15,000 mark for the first time since January 2008 in Tokyo. However, the session is likely to be dominated by first-quarter euro-zone economic growth data, and gross domestic product figures for a raft of individual European countries.
German growth data has already disappointed Wednesday and French data have shown the country to be in technical recession.

subset: commoncrawl


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- News
- Betas
- Finals
- Systems
- Handhelds
- Divisions
- Browse
Amazon to increase Kindle Fire production due to pre-order demand
By News Division On October 29, 2011 · In News, Retail, Technology
Amazon.com Inc. said this week it is increasing production of the
Amazon in Nov. will sell the Kindle Fire tablet due to high pre-order demand.
The company said in a statement it is increasing production capacity to millions more units than originally forecast.
"…based on what we're seeing with Kindle Fire pre-orders, we're increasing capacity and building millions more than we'd already planned," said Jeff Bezos, founder and CEO of Amazon.com.
Amazon in Nov. will sell the Kindle Fire, a new 7-inch color tablet at $199.99.
Applications include the Amazon Silk Browser, E-Mail, Amazon Instant Video, Amazon Appstore, and Amazon Cloud Drive with unlimited cloud storage for Amazon content.
Finally, each Kindle Fire will include a free month of Amazon Prime membership.
Amazon in Sept. announced new Kindle models including the Kindle at $79.00, the Kindle Touch with touch display and built-in Wi-Fi at $99.00, and the Kindle Touch 3G which adds free 3G wireless functionality at $149.00.
Follow us on Twitter @PunchJump, @WeLoveHotDeals, @PreOrderBonus, @Punchissimo, and visit us at Facebook.
Comments are closed.


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Janet C. Lucas
Jan defines her practice through the scope of transactional law. That focus has led to a diverse experience of issues that has included negotiations, litigation, analysis, and policy for both public and private sectors. Having served her residential school district as a member of the board for over twenty years, she became especially concerned with education-related matters. That interest has developed into a significant emphasis of her practice, while she continues to serve her transactional matters.
Her litigation experience has included New Jersey Civil and Criminal courts, the New Jersey Appellate Division, Office of administrative Law, as well as various agencies and hearings in the public domain.
Attention Lawyers - sign up here to join the directory.


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- Crunch young children
- What states are accompanied by a crash in the joints
- Anomalies structure
- connective tissue Benign hypermobility
- Syndrome Marfan
- Syndrome Ehlers-Danlos
- «snapping hip" syndrome
- Osteoarthritis
- Symptoms of osteoarthritis
- patellar instability
- Tendonitis
- Gout
- Getting rid of crunch without drugs
- When should you seek medical advice
Probably everyoneat least once in my life I felt a fortune on "crunch".Some may make such sounds fingers, or knees with an enviable constancy.If this phenomenon is not accompanied by pain, swelling, limitation of movement, it is an absolute rule.
On the causes of a crunch in joints without pain, scientists have argued for a long time.Now there is a unified theory of the "cavitation bubbles".The fact that synovial fluid over the joints, a large amount of dissolved carbon dioxide.When excessive or sudden movements in the joint cavity portions are formed with different pressures, resulting in the dissolved car
Crunch young children
Many parents do not pay attention to other sounds in the hands and feet of their children.They appear almost immediately after the start of active operations, that is still in infancy.In 99% of cases, these sounds should not cause alarm.The fact is that young children are inherently hypermobility.These cartilages have not crystallized until the end, but because there is a crack on movement and clicking.If this does not cause pain crumbs and does not limit his desire to explore the world, something about the crunch in the joints of the child to forget and not to worry.
What states are accompanied by a crash in the joints?
Some features of the locomotor system and diseases can lead to the appearance of articulate sounds crisp.The main difference from the norm - the presence of other symptoms (pain, redness and swelling, limitation of movement, stiffness).
reasons crunch joints:
- Anomalies structure
- connective tissue "snapping hip" syndrome
- Osteoarthritis
- patellar instability
- Tendonitis
- Gout
Anomalies structure
connective tissue must have all seen in the circusor big sports people with a surprisingly supple body.During the presentation, they literally "twisted in a knot", causing the joints to bend to the limit.In addition to the rigorous training they have another secret - hypermobility or connective tissue dysplasia.Under this vague term hidden genetic syndrome, in which the joints and ligaments become very mobile and stretched here and crunchy sounds in them.On the one hand, it gives a chance to show their talents.On the other - could face some complications.
syndromes, accompanied by connective tissue dysplasia:
- benign hypermobility syndrome
- Marfan syndrome and marfanopodobnye state
- Ehlers - Danlos
Benign hypermobility
This is a relatively harmless ability to perform movements with large amplitude.This syndrome rarely leads to a decrease in quality of life.Children with this feature a bit more often get sprains and strains, but otherwise they are no different from their peers.Therefore, a large amount of movement and a crunch in joints are relatively safe.
Symptoms of hypermobility in points:
- Extension pinky 90 degrees - 1 point each side
- Bringing thumb sideways and back until it touches the forearm - 1 point each side
- elbow hyperextension at 10 degrees - for1 point each side
- hyperextension knee 10 degrees - 1 point each side
- ability to touch your palms to the floor without bending the knees - 1 point
in assessing 6 points more likely hypermobility.
Marfan Syndrome Marfan syndrome
and similar state - this is a rare, genetically caused connective tissue abnormality.Violations found in the musculoskeletal, cardiovascular system, skin and eyes.
Symptoms of Marfan syndrome:
- high growth, long and thin limbs
- cock or funnel chest
- flat
- low blood pressure
- hypermobility and crunch (the elbow movement may be limited)
- myopia
- smalllower jaw and narrow face
- scoliosis
Among the possible complications of the syndrome can be endocarditis, mitral valve prolapse, problems with vision, light, posture.Such children are in need of inspection at genetics and life-long observation by a doctor at least once a year.
Syndrome Ehlers-Danlos
By its nature, this syndrome is genetic and also very similar in features to the Marfan.There are several types of the disease.Some of them almost do not reduce the quality of life, manifesting only movable joints, stretch the skin soft and prone to scarring.Some forms can be dangerous, as it promotes the rupture of large vessels and internal organs.Symptoms of the most common forms are similar to Marfan syndrome.To diagnose need advice genetics, ultrasound of the heart.
«snapping hip" syndrome
Many probably know the feeling when you try to get up at the hip click is heard, thus there is a feeling of "jamming."This sound occurs when part of the muscle or tendon rubs against the projecting part of the femur.In most cases, these flicks are painless and harmless, although they can irritate their regularity.Particularly affected by this scourge of the people involved in dance or sports that require repeated bending legs.
reduce the appearance of the syndrome will help limit physical activity, stretching exercises muscles of the legs, cold packs and anti-inflammatory drugs.
chronic, relentlessly progressive disease of the joints, in which it occurs degenerative changes, called osteoarthritis.It is based on "blurring" of the articular cartilage with subsequent changes in bone and secondary inflammation in the surrounding tissues.These or other signs of osteoarthritis occur in almost 20% of people in the world, and women suffer more often than men.
The main reason for such a major change is considered a mismatch between the load on the joint and its ability to withstand such loads.Therefore, a greater risk of developing osteoarthritis experienced by people with obesity, occupational or household physical activity, injury, and other connective tissue diseases.Not the last role is played by age and genetic predisposition.
Symptoms of osteoarthritis
Onset goes unnoticed, with the light of changes in the affected joints.Most often suffer from hip, knee joint, fingers and toes.First symptoms appear in the same place, the progression of new fields are captured.
- Pain
- Crunch at the time of movement
- swelling in the joint, its deformation
- Stiff
- Fatigue of muscles near the joint
- Periodic flushing of the joint area, fever
- limited movement
pain in osteoarthritis maybe of different nature.Most often, they are mechanical, that is amplified by the end of the day and subside after sleep.If there is a secondary inflammation, the pain may be aggravated by motion, then subside and occur when excessive load.Often the pain is the result of muscle spasm.Sometimes the pain radiating.For example, in coxarthrosis they spread down to the knee (for details on the causes of pain in the knee joint).
Over time, the gentle crunch of coarsens, and the pain worse and more frequent.There is stiffness, limitation of movement.This reduces the quality of life and can lead to disability.
To diagnose the disease, there are several criteria:
- Clinical
- pain and a crunch in joints that occur in the late afternoon or in the first half of the night
- pain, worse after exercise and reduces alone
- deformation of joints due to growths ends of bones
- Radiographic (narrowing of the joint space, the presence of bony protrusions - osteophytes)
changes of cartilage in the spine (low back pain) is also referred to as arthritis group.In addition to pain and a crunch in certain spine can be identified additional symptoms.This radicular syndrome (sciatica), violation of the pelvic organs (problems with urination and defecation), dizziness, and blood pressure drops (with cervical osteochondrosis).By the time the clicks in the spine are other, more bright signs, there are quite a long time.
to treat most types of osteoarthritis using pain killers and anti-inflammatory drugs (Nise, Diclofenac, Tramal), the introduction of glucocorticoids into the joint area between the symptoms subsided - physiotherapy.It is important to observe the regime of work and rest, as well as engage in physical therapy to preserve joint mobility.(Read more about the treatment of osteoarthritis of the hip and the knee.)
patellar instability
patella, or kneecap, - it is a small bone on the anterior surface of the knee.It is located on the penny, the muscles attaching to the femur and tibia.This makes it possible to strengthen their cravings and reduce the pressure on the joint.
Normally, the patella is centered.Sometimes it is a little bit biased, or even completely out of his bed.This condition is called patellar instability.Its cause may be trauma, especially the legs and the structure of the connective tissue abnormalities.
- pain and crunch in the knee when moving
- pain when sitting
- Swelling knee
- Sensible displacement of the patella or out
confirm the diagnosis the doctor can during the inspection, X-rays are sometimes required.Treatment of patellar instability is usually conservative.Well help special exercises for flexion-extension legs, bandages and splints.
tendon inflammation or tendonitis usually occurs in the shoulder joint, elbow, knee, or ankle.The appropriateness of the term "tendinopathy", since the defeat of the tendon fibers are not always accompanied by inflammation.
Signs of tendonitis:
- With lateral or medial epicondylitis feels pain in his elbow on palpation, or is characterized by unpleasant sensations in bending arms at the elbow
- Inflammation of the tendons around the knee during active movements brush
- tenopathy biceps causes crunch and pain when trying to rotationleg in the joint, as well as palpation
- defeat tendons Ahhilova entails pain at 6 cm above the heel when trying to bend the leg at the ankle.
common symptom for all types of tendonitis will crepitus - a slight crunching feeling when the tendon, and sometimes even during movement.For diagnosis using X-ray, ultrasound and MRI, especially if there is a suspicion of injury.Treatment consists of rest, ice-cooling, the first 2-3 days, pain relief with analgesics and NSAIDs.In some cases, it helps physical therapy and the use of corticosteroids.
Argued that the crunch in the joints can be caused by the deposition of salts in them, and that this state is almost all, have stepped 50-year milestone.It is a myth not supported by scientific evidence.There is only one type of joint disease with deposition of salt crystals in them - this is gout (and pseudogout).
defeat salts of uric acid may not be noticeable, but can occur rapidly, exhausting the patient frequent gouty attacks.Risk factors for the disease are obesity, genetic predisposition, kidney disease, and eating habits.
gout begins with acute inflammation in the metatarsal phalanx of the big toe.Slightly less such an attack occurs in the ankle, knee and toes.Within 8-12 hours the pain reaches a maximum, the joint becomes red, swells, becomes hot.Even the touch of the sheets (and attack often occurs at night) causes increased attack.Over time, the symptoms subside until a new gouty attacks.In addition to pain may be a crunch in joints and accumulation of salts in the area of the eyelids and ear cartilage (called tophi).
for diagnostic tests used in the uric acid level (including in the periarticular fluid), X-ray or ultrasound joint, MRI.
Treatment of acute gout attack is carried out using NSAIDs (except aspirin) and corticosteroids.Chronic diseases are treated with allopurinol, febuxostat, uricase.To control the state need to follow a diet.We should avoid drinking alcohol, eating red meat, canned food, soft drinks and coffee (read more about the symptoms and treatment of gout).
Getting rid of crunch without drugs?
Massage Therapeutic massage is useful for almost all problems with joints.It is important to remember that acute inflammation - this is a direct contraindication to massage.A case of chronic processes, stroking, kneading, rubbing the feet and hands increases the blood flow, relaxes muscles, distributes the liquid inside the vessel.The main thing - to seek help from a professional masseur, who knows why crackle joints, so as not to aggravate their condition even more.
Proper nutrition
noted that obese people are more likely to suffer from osteoarthritis of the hip and knee joints, they more often gout.Therefore, normalization of weight, frequent small feedings useful products required for health promotion.
balance articular cavity in violation of its structure begins to actively lose moisture.It reduces the amount of synovial fluid.Therefore, sufficient intake of water is necessary for the patient's joint.No need to drastically increase the number of cups of tea or coffee - it just hurt.It is enough to drink a glass of water in the morning, at night and during meals.
Physical activity
Daily walks and physiotherapy - what you need for the treatment of a crunch in joints.If we add to this, and swimming, the improvement will not take long.But before the introduction of new exercise you should consult with your doctor, as some movements may be contraindicated.
Traditional recipes
effectiveness of treatment of folk remedies have not been confirmed.In most cases the improvement associated with the placebo effect, that is based on samoubezhdenie.If in this case there are no contraindications, such therapy is well suited, because the main thing - the result.
- Pour 5 g of dry birch buds with water (1 glass), bring to a boil, let it brew.Eat a third cup before each meal.
- 1 tablespoon celery root spoon to pour 2 cups boiling water, let it brew, strain.Take 3-4 tablespoons per half hour before meals.
When should you see a doctor?
- If a strong crunch arose suddenly after
- injury If there is pain
- If the joint is red and swollen
- If limb movements are limited or impossible
- If there is any deterioration of health (fever, muscle aches, and so on)


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Hand Hook
Now here is a weird one indeed. These guys are called hand hooks. Some are hookish in nature, all are very handish. There are five styles of hands to choose from, and I love the names. They are called C'mere, Grab, Offer, Bestow, and Om. Bestow and Om have pictures in the More Photos link over on the product page. Om is like an orchestra conductor's hand; wand and all. Bestow costs a bit more because it comes with a candle stick and a flower vase.
These are apparently casts of the hands of the fellow who designed these products. The site gives great use suggestions like soap container and coat hanger. I'll take the freedom to suggest a few more. Offer could be used for high-fiving practice. Om looks like it would be great for kids to use for sibling torment. C'mere could be used to scratch behind the ear. Another use for Offer could be a good solid facial slap.


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One of the more intriguing prospects in the Peach State is Devonta Bolton. Bolton is an athlete that could play on either side of the ball. He lines up at safety and wide receiver at Norcross and...
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So yesterday I had one of "those days." Not a red letter, life altering day, but the sort that makes you want to laugh and cry all at the same time because it just keeps taking a turn for the worse.
The sort when you want to tell total strangers that in light of your current circumstances you are terribly clever and intelligent.
The sort you want to tell a friend about, because it's hilarious so long as you're not in the middle of it. So let's have a coffee date shall we, and I'll tell you about "that day I had."
It will make you feel better about your life and I'm okay with this.
The day started with a marriage spat, which set both Kel and I on edge. He took the kids to the zoo and I headed off to the coffee shop to get some work done.
Afterwards I wanted to hit up Barnes and Noble to crack out on some new books. But, I knew that browsing would turn to buying, which wasn't in the budget.
But the library was free so I decided to head there.
But, wait. I didn't yet have an area library card and to get one I would need a new, Michigan driver's license. This would require a trip to one of the worst places in the world, the Secretary of State's Office (DMV).
So, I returned home to get the proper documents to get a new license so I could get a new library card.
There was a line out the door but I decided to brave it, I was kid free and I needed to jump this annoying hurdle so life could go on. So I waited in line to take a number. When I got up to the desk the lady checked over my documents and promptly told me that I lacked "proof of presence."
I almost sassed off and told her that I was present… and that was proof. But I refrained.
But she smugly sent me back home for either my original birth certificate or a passport, because my current documentation was inadequate.
I want to give up… but I was going to finish this dang it so I drove home to get my birth certificate, grabbed a little lunch and headed back with steely resolve.
Halfway there I realized that in the act of getting lunch I'd left the bloody birth certificate on the counter at home. I plopped my head on the steering wheel so loud that the horn made a short, angry honk.
I turned back around, AGAIN and walked back into the house AND grabbed my BC off the counter and drove back to the office…. again. Continue reading


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Apply for this job
Degree or equivalent in chemical, electrical, controls, or automation engineering
Experience of working within a manufacturing environment.
Technical expertise/ knowledge Control systems (PLC, DCS, PLC, SCADA)
In depth technical expertise/ knowledge in several scientific and automation engineering areas which will include a number of the following:-
-Instrumentation (sensors, actuators, PMT)
-Motion and control (invertors, servo)
-Electrical Design (control panel and field wiring)
-IT Infrastructure (network ,firewalls, data storage)
-Manufacturing Execution Systems (Data historians, EBR, OEE, SAP)
-ISA Standards (S95, S88)
-P&ID nomenclature and electrical wiring diagrams
-Communication networks and protocols (serial, Profibus, Ethernet)
-Integration technologies (OPC, XML, BatchML)
-Database knowledge (SQL, Oracle, data warehousing, architecture)
-EHS process and standards (CE, PUWER, HAZOP, CHAZOP)
Broad knowledge and practical experience of computer and application validation (preferably using GAMP methodology), cGMPs, and 21 CFR Part 11 in an FDA regulated environment
Working knowledge and understanding of current Good Manufacturing Practices including Good Documentation Practices
Working knowledge and understanding of EHS Practices with respect to the installation of automated plant.
Proven track record in providing automation support and maintenance for instrumentation, automation and controls
Capable of working in multi-disciplinary teams across engineering projects, new product introduction and technology projects.
Job Purpose and Key Responsibilities:
Provide technical expertise and implementation resource for a wide range of manufacturing automation and control systems activities on new and existing equipment and facilities.
Involved in all aspects of automation, instrumentation and control systems through from concept, system design, and implementation, validation and support transition.
Key Responsibilities
Leads improvement and technology projects and lead trouble shooting in response to identified needs.
Responsible for identifying technology related risks to project.
Would work in cross functional engineering teams, cross functional technical teams within site and cross functional project teams with R&D.
Own project teams and automation engineering team
Work within standards and operational policies / procedures for the automation systems on site.
Ensure all work executed is carried out in compliance with current legislation and policy
Provide second level support to the existing automation systems to ensure production targets are met.
Identify, develop and implement approved automation system changes to support manufacturing operations
Support the implementation of the site automation strategy
Identify external uncertainties that may affect their work and plans contingencies.
Support the NPI process by providing automation engineering and expertise
Keep up to date with technologies to ensure the appropriate solutions are utilised to maximise business benefits
Work at all times in line with current EHS legislation and the company policies and procedures to maintain own, team and public safety
Implement and manage coding standards for software changes under full change control.
Ensure site documentation is appropriately managed
Develop, implement, measure, report and enhance Service Level Agreements with Client departments.
Ensure that systems are maintained in a validated state using such approaches as Change Control and Configuration Management
Provide second line support as required to client groups in compliance with agreed SLAs
Implement and deliver training programmes for plant staff
Ensure critical spares coverage and lifecycle investment plans are developed for all automation systems
Vendor management including third party project resource and support agreements
Contribute to the design and development work in support of equipment selection, installation and validation (including business process change)
Provide training for other process or production engineers in the lead expert discipline
Assist with the improvement of process control systems and working practices, and improve process capability by working in Partnership with the Site's New Product Introduction and Technology Group.
Provide process automation expertise and lead safety assessments where appropriate e.g. CE, PUWER, HAZOP, CHAZOPS
Working to high standards of Quality and Safety in compliance with contemporary industry and internal standards.
Identify opportunities to improve manufacturing processes and support continuous improvement activities


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Date Created: 24/06/2013
Date Modified: 04/06/2015
Country: China
Genre: Action
Year: 2006
Runtime: 110 phút - Movies
Quality: HD
Director: Dennis Law
A young Chinese martial arts national champion, Kong, comes to Hong Kong on a short contract with a Chinese opera group. A small time gambling boss, Ma, is so impressed with Kong that he wants him to be his fighter in the underground all-contact boxing world. In need of money, Kong makes up his mind to enter the underground boxing scene with his girlfriend Tin, and together they are under control. Kong's fighting skills made him unbeatable in the arena, but after each win, he gets himself in too deep with the underground world.


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Aaron from Canada Looking for some coordinated games competitive or not.
No high level comp experience in mainstream games but have played a good bit of csgo and reached global elite, and have a lot of experience playing tracking based shooters with long TTK
Looking for players to learn the competitive scene with. Comfortable with: mercy/lucio 76/tracer/reaper/bastion winston/roadhogLate Afternoons Evenings Weekdays Weekends
AFRICAAAA has not set up his/her profile.


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What perk do today's workers appreciate most? According to 30 percent of chief financial officers (CFOs) polled recently by Accountemps, flexible schedules top the list. Retirement savings plans ranked second, cited by 17 percent of those surveyed, followed closely by extra time off with 16 percent of the response.
The national poll was conducted by an independent research firm and developed by Accountemps, the world's first and largest specialized staffing service for temporary accounting, finance and bookkeeping professionals. The survey includes responses from 1,400 CFOs from a stratified random sample of U.S. companies with 20 or more employees.
CFOs were asked, âWhich one of the following employee benefits do you feel workers value most?â Their responses:
|Flexible schedules
|Retirement savings plans
|Extra time off
|Spot bonuses
|Health care benefits/health insurance
|Equity incentives
|Don't know/other
âLean staffing levels mean many employees are working longer hours. At the same time, a growing number of professionals must meet mounting personal obligations, including caring for children and elderly relatives,â said Max Messmer, chairman of Accountemps and author of Motivating Employees For Dummies (John Wiley & Sons, Inc.). âFor this âsandwich generation' of employees, increased control of their time enables them to balance competing demands.â
Added Messmer, âNot all companies are able to provide flexible schedules; it depends on the nature of the business and the number of people employed. However, firms that can offer this benefit may have an advantage when recruiting and retaining staff.â
Messmer advised managers who are considering offering flexible work arrangements to ask themselves the following questions:
- How will it affect customer service? Staggering work hours might allow you to accommodate employee schedules while being more available to customers. However, if your business has certain peak periods, you may want to have all personnel available during those times.
- How strong is the employee work ethic? Flexible schedules work best for self-motivated professionals, particularly if they'll be doing their jobs when no one else is around.
- How dependent on teamwork is the organization? If impromptu meetings are where the best ideas are born, you'll want to ensure significant overlap in employee schedules.


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Biofreeze Cold Therapy Review
You step off a curb and twist your ankle. You bend over to pick up a heavy object and feel a weird twinge in your lower back.
Most of us know that we need to apply ice to muscle strains and sprains ASAP. But many tend to skip this important step that reduces swelling and speeds the healing time. Why do we do this?
Ice is cold, it is uncomfortable, and can often cause pain to intensify before numbing the area. No wonder you want to skip that ice pack!
Ice-o-phobes Let Me Introduce You To Biofreeze
BIOFREEZE Pain Relieving Gel is an analgesic cold gel or spray that can be used alone and in conjunction with ice therapy. A study conducted on people who had acute (sudden) non-complicated neck pain (pain was determined to be soft tissue) showed that Biofreeze decreased the pain nearly two times more than ice. Not only did it substantially decrease neck pain, but the diminished pain lasted 9 – 10 times longer than those people who were treated with ice.
Don't Throw Away The Ice Packs or Bags of Frozen Peas!
Although Biofreeze does relieve pain better than an ice pack, ice is still recommended if the injured area is experiencing swelling. It is not known if Biofreeze is as effective on swelling from an acute injury as the traditional ice pack.
But Don't Despair!
What Biofreeze will do is eliminate the shock of placing an ice pack on a new injury. Upon application, Biofreeze immediately goes to work cooling and numbing the area. Apply Biofreeze to the area first, wait 5 minutes and then apply the ice pack. Doing this will ease the discomfort of the ice pack. There is no longer reason to fear the ice!
Using Biofreeze In Massage Therapy and as a Massage Therapist
I often use Biofreeze in my massage therapy practice. When a client arrives complaining of sudden onset pain I immediately apply Biofreeze. This accomplishes two goals: First, it immediately relieves the pain making the client more comfortable. Secondly, it allows the area to be worked more comfortably to relieve the muscle spasm.
After a day of work as a massage therapist, I apply Biofreeze, wait 5 minutes and then ice my hands for 10 minutes. This helps reduce and eliminate achiness and inflammation in my hands allowing me to get up pain free the next day and massage again!
When To Use Biofreeze Cold Therapy:
- As soon as possible anytime there is a question of possible muscle strain or sprain. This will decrease the pain, help maintain mobility, reduce heat and may help reduce inflammation.
- It is great for weekend warriors, desk jockeys, people who are on their feet all day, anyone who suffers with daily or occasional muscle strain and overuse.
- Consider Biofreeze if you are arthritis suffer. Many people with arthritis claim that Biofreeze works better when joints are swollen. Once the swelling recedes they will switch to heat therapy. Remember if you try this to make sure to wait several hours and wash the area thoroughly to avoid a reaction.
- It can be used up to 4 times in a 24 hour period.
When Not To Use Biofreeze:
- If you are unsure if there is a broken bone or internal bleeding. Go to the doctor!
- Do not use on wounds, sores, rashes or burns
- Do not use around the eye or nose area
- NEVER EVER use with any type of heat therapy. At best the heat will null the cold therapy effect. At worst you could end up with a nasty rash or burn!
Recommended for Personal Use
Biofreeze in one product I think everyone should keep on hand for sudden muscle strains and injury. You will also find that if you apply Biofreeze before using ice, you will be much more likely to use ice!
Recommended for Professional Use
Clients love Biofreeze! It can be used to help immediately reduce pain from an acute muscle injury. It is also useful after some applications of deep tissue work, stretches or exercise to help relieve discomfort and sooth an overworked area. It is an item I recommend for every pro that works with soft tissues.


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Originally published Friday, June 29, 2012 at 2:31 AM
Eurozone inflation unchanged at 2.4 percent
Inflation in the 17 countries that use the euro was an annual 2.4 percent in June, a figure that leaves the door open for a possible interest rate cut by the European Central Bank.
The Associated Press
Inflation in the 17 countries that use the euro was an annual 2.4 percent in June, a figure that leaves the door open for a possible interest rate cut by the European Central Bank.
The figure was the same as in May and matched average market expectations.
Inflation has been gradually sinking in the eurozone thanks to a slack economy and lower oil prices, and the ECB expects it to fall to 2 percent sometime next year. Mario Draghi, the head of the European Central Bank, said June 15 that there was no threat of inflation in any eurozone country.
That was a telling remark because the bank's chief job is to keep inflation under control. Lower rates can stimulate growth but can worsen inflation, meaning the bank can only cut its benchmark refinancing rate if it can argue that inflation is under control.
Draghi's stance thus left the door open for a potential interest rate cut when the bank's governing council meets next week. A weakening eurozone economy puts pressure on the bank to cut to support growth and aid the eurozone in digging out of its crisis over too much government debt. The European Union's executive commission predicts the eurozone will shrink by a relatively mild 0.3 percent this year, and recent data have suggested the downturn could turn out worse.
Analyst Christoph Weil at Commerzbank said that there was "no obstacle to an ECB rate cut from the side of inflation." Inflation risks remained low because companies are finding it difficult to raise prices because of weak demand for their products. Commerzbank thinks the bank will cut the refinancing rate to 0.75 percent from its current 1.0 percent at next week's rate meeting.
The refinancing rate is what banks pay when they borrow from the ECB. It influences other interest rates that affect the cost of borrowing for banks, companies and consumers.


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The meeting will start promptly at 10:30.
Please note that this agenda is subject to change prior to the meeting.
Final Agenda
1. Welcome, introductions & apologies - Part 2 only (closed session)
2. Minutes of previous meeting - Part 2 only (closed session)
3. Matters arising - Part 2 only (closed session)
4. Announcing publicised decisions/ declarations of interest – Part 1 only (open session)
5. Accreditation decision making – Part 1 AND Part 2 (open and closed session)
• NICE - Multiple Technology Appraisal
• NICE - Interventional Procedures
• NICE – NICE guidelines
6. Process manual implementation - Review of renewal process - Part 2 only (closed session)
7. Any other business – Part 2 only (closed session)
8. Date and time of next meeting – Part 2 only (closed session)
9. Summary & close – Part 2 only (closed session)
Thursday 14 January 2015, 10:30am, NICE offices, Manchester
Please note all timings are approximate.
To print this agenda, please right click and select 'Print' from the menu
To register
You will receive an automated email response when you submit the registration form. If you do not receive this automated response your registration request has not been received, and you will need to complete and submit the registration form again.
The closing date for registration is Thursday 05 November 2015. Please note that it may not be possible to accept late registration requests.
Should you have any queries regarding attending this meeting, please contact the Meetings in Public Coordinator, Sandra Robinson, firstname.lastname@example.com
Please note that registrants wishing to conduct a research study on the committee meeting and/or NICE processes will require prior permission and should contact NICE Enquiry Handling by email email@example.com
Further information about conducting research is also available in our Common Questions and Answers about meetings in public document.


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Forex Mega Robot is the latest robot developed by Rita Lasker. Forex Mega Scalper Robot has been optimized to trade EUR/USD and GBP/USD pairs on M5 timeframe. From Sep 15 to Oct 17, this robot made 218 trades and won 203 trades losing only 15 trades. Take a look at the screenshot below.
Spreads are very important in scalping. This robot utilizes a Spread Control Option that helps to avoid opening trades when the market is moving sideways or during the night when the spreads are usually high. This robot also uses a Trend Filter that only trades in the direction of the trend on a higher timeframe. There is a Flat Filter as well that keeps the robot from opening trades during the time of high impact news release. It also has hedging on/off feature and a trailing stop loss
The robot runs on its own totally on autopilot once you are installed it and adjusted the settings according to your risk appetite.
You can try this robot on your demo account for 2 months. Just install it on the demo account and let it run uninterrupted for a period of at least one month. At the end of the month check the performance.


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At 32-years-old, Swedish rider Daniel Zetterman has already experienced the resounding success of a rider many years his senior. Born and raised in a family of horsemen, Zetterman and his brother Alexander came up through the Swedish pony, junior and young rider ranks before turning professional, and both brothers have successfully competed in the United States.
But it's Daniel who is taking the step forward of basing himself full time in the USA as he comes back into the profession with new goals after four years training privately for Swedish young rider Viggo Björklund.
Zetterman, who was not yet out of his 20s when he rose to international fame with the Swedish warmblood gelding Glory Days (Cardento 993 x Diamond Serpent), guided Björklund to young rider success through his junior years, and with Björklund now transitioning to university, Zetterman sees the chance to establish himself as an independent trainer and rider.
With plans to spend his first summer season in the States under the new shingle of his own Zetterman Equestrian LLC, he is excited about what the future holds:
Noelle Floyd: The international show jumping community knows you best from your record with Glory Days, but you have in no way been resting on your laurels since that partnership. Can you catch us up on your current situation?
Daniel Zetterman: After training privately for a Swedish family for four years, I started my own business last fall together with my American girlfriend Aly Rodriguez. With Zetterman Equestrian LLC, I'm riding for horse owners, training clients—and using my experience with everything from educating young horses all the way up to five star grand prix classes. I have the whole package really with all my experience. I'm really excited now to spread my wings here in America.
NF: And what's your plan for the coming season?
DZ: This will be my first summer here in America. The last two years I've been in Kentucky for the spring with my Swedish clients, and then Europe. But now I'm very excited to stay in America and be based here. I'm really looking forward to going to New York, I've heard a lot of good things about it—Old Salem, and also Saugerties, Lake Placid and perhaps The Hamptons. In my East Coast summer tour will also include Upperville, Virginia and Tryon, North Carolina. I'm looking forward to connecting people with very nice horses that we can find in Europe and bringing them over to good clients. I do a lot of sales and want to continue with that as well.
NF: For someone whose home circuit is on the European continent, what appeal do you find in being based in the USA?
DZ: Bringing up young horses and doing the shows in Europe is cheaper than in America, but over here in the USA, you're right in the business. It's a better setup, I think, also with the competitions. When I'm in Sweden, or a national show in Holland or Belgium, you've got a mix of classes with juniors and young riders, with amateurs and professionals. I really love the system here in America because when you're training people and bringing them up, they are in their own division. They have their own courses that are accustomed to their skills and their knowledge and will have a chance of being successful without having to race against all the top professionals.
NF: And what does your own string of horses look like right now?
DZ: For the moment right now, I sold all my horses when I came over to America so I have no horses of my own at the moment. I've formed good partnerships with other horse owners and investors and also built good relationships with clients. Right now, I have two seven year olds with clients that I'm educating. I'm just really getting started, not a lot of people know my position and what I can offer, and I hope to change that.
NF: So your take on the American system is that it does a good job to set amateurs up for success.
DZ: Yes, what I'm really impressed with in America, is that in general the American amateur is very good over here, very very good. Americans have a great start with their system; they focus very much on the trainers teaching the riders very good position and feeling and rhythm, and that's something that's different than in Europe. Our advantage in Europe is that we are probably better at developing flatwork and taking care of young horses—we focus more on the horse.
Over here, the students get more focus on themselves and the horse is bought to do the job, so you don't have to teach the horse as much. There's good and bad on both sides, really.
But if you combine that, I think that's going to be my advantage being European, to have the whole art of how to do everything from scratch and being very good at training—that's why I think I've been very popular in my country and also it's coming along here in America, people are starting to see that.
NF: That's right! You and your brother Alexander have experienced widespread recognition and we have to say—fame—in your home country. Can you talk a little about that?
DZ: Well already, as a young kid, my father was very well known in Sweden and Europe for being a top rider and having a big sales barn where we sold a lot of horses to America in the 80s and 90s and early 2000s. Our family name in Sweden and in Europe became bigger because both my brother and I were on all the Swedish teams for ponies, juniors, young riders, and all the way up. That really expanded our business because it wasn't only our father anymore, now it was the two boys taking up the sport.
We got very successful—in Sweden, there are nine million people and riding is the second largest sport in the country—so we got very well known. We really took off when we were on a TV show–we got one million views on the TV show, so it was a really good thing for us, plus it was a big kick. I think me and my brother, we still have a huge fan base of young people in Sweden.
NF: Glory Days was such a pivotal horse for your career. What did you learn from him?
DZ: I was relatively young when I started riding him because we had bred him ourselves. I broke him in when he was a young horse, and I did everything with him all the way up.
He was a fantastic horse. I was very successful with him in all the National Championships for young horses all the way up. We were finalists over two years in the 6 and 7 Year Old World Championship, and I won my first ranking class with him, and we won the Swedish Championships together. He taught me everything. We went to all the big shows—Aachen, Dublin, Hickstead, Barcelona, you name it. I was the standing reserve for the Olympics in London. He's the kind of horse that made my name internationally, but also I learned so much from educating and bringing him up. He led me to develop my riding on making other horses better.
NF: And coming back to where you are now, what do you think your biggest challenge will be for this upcoming year?
DZ: Probably to get everything set up the way I would like to have it. I know I have the time and potential to take care of more clients at the very high level for training and riding and also the biggest challenge for me as a rider, is to really get back into the sport with some good partnerships with horse owners and sponsors.
It's a challenge to get introduced to that kind of market and for people to get to know me and see my work because, like I said, I would have a greater value just staying in Europe and Sweden. Over here, people kind of know me, but they don't really know exactly what I've done and how I work. I'm really looking forward to showing that and working hard and try to establish what I've done in Europe, over here in America.


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Ramat Gan House
- by Michael Dachstein
- Nov 24th, 2011
- Architecture
Tel-aviv-based studio pitsou kedem architects has designed 'ramat gan house', a single family residence in ramat gan of haifa, israel. Projecting itself as a solid white cube to the street, this structure opens itself to three internal levels as well as a wrap around veranda and pool which wraps two sides of the dwelling. as inhabitants pass through the entrance within the solid elevation, an open floor plan with views to a perimeter green space is revealed. beginning at the basement level and connecting to the ground and first levels, a focal staircase comprised of slender steel treads maintains its presence without obstructing views to the patio and outdoor area.


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Let's Get Started Clinic
(ages 6 - 12) 4 hours of instruction
The most affordable way to get your young golfer started off on the right foot. In four 1 hour sessions new junior golfers will learn the basics of the golf swing. Our highly trained staff of PGA of Canada Professionals will teach juniors basic swing fundamentals. Focus will be placed on the starting position, the backswing and the finish position. At the end of these sessions your junior will be able to swing the golf club with a balanced, athletic motion.
2018 Group Schedule will be available February 15th 2018
4 X 1 Hour: $100.00 CAD (+hst) per person
Parent Junior Clinic
(Ages 5 - 11) 4 1/2 hours of instruction
The same program as our Junior "Let's Get Started" Clinic but with mom or dad to make the learning more fun and lasting. These three 1 1/2 hour sessions teach your child the basics of golf in a fun learning environment. Parents will benefit from the instruction as they help their child learn the fundamentals of golf.
If your child is older than 10 years old please call one of our lesson consultants to discuss if this is the best program for your family.
2018 Group Schedule will be available February 15th 2018
3 x 1 1/2 Hour: $175.00 CAD (+hst) (87.50 per person)


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Alia gives Catt Sadler and Giuliana Rancic the inside scoop on how to wear the season's biggest red carpet trend to all your holiday events (for under $100!)
Forget the traditional GIFT GUIDE- Alia and ELLE teamed up to create the first ever, GIF GUIDE...May every gift you choose evoke exuberant joy- no matter what your age. See the whole guide here
SEEING RED/ Alia gets you in the know on the latest trends with easy ideas and insider tips on how to wear the color of the season.
THE STYLE SCOUT x EMIRATES AIRLINES
Chic travelers don't pack light- they pack smart. Whether you're traveling across the state or over an ocean, Alia's easy packing tips guarantee a stylish trip- with options for any adventure that could come your way.
ELLE STYLE CORRESPONDENT, Alia Ahmed-Yahia shares her inside fashion and beauty secrets to a stylish life "on-the-go"
Alia accepted TODAY's style challenge: create chic looks under $100 (that don't look inexpensive) You'll be just as shocked as Willie and Tamron were at these chic, summer style ideas.


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Family business
Family firms represent two-thirds of businesses in the UK and account for approximately half of the economic activity and private employment. The picture is similar in most countries throughout the world.
The diversity of family businesses and their behaviour make them an important field of study and one which is naturally multidisciplinary, involving sociology, economics, management theories, culture and history. Understanding family firms requires the analysis of the complex interaction of family and firm, the forces underlying family values and the way these shape the business culture, behaviour, and capabilities of firms.
Our research has shown that different types of family firms can be identified and that high-performing family firms are an outlier group that differ in size, ownership and management structures from the stereotypical 'average' family firm.
Family firms tend to be older than non-family firms and many of the longest surviving firms are family-owned or controlled. It is often said that innovation is crucial to the survival of firms. These longstanding family firms provide interesting lessons for others on how to sustain innovation across generations. Intergenerational succession lies at the heart of the longstanding family firm. Succession has in it the potential for change and regeneration of the firm, based upon a bedrock of shared experience and history.
It is this potential for change and regeneration described as 'interpreneurship … intergenerational entrepreneurship leading to transformation' which powerfully links family business with the study of entrepreneurship. The future prosperity of any family business, and indeed its ability to survive, is inextricably linked to the succession process and the way it is handled.
This interplay between the continuities of past experience and the need for change lie at the heart of the family business. They mean that the decisions to innovate and change, made by later generations, are every bit as entrepreneurial as the original decision to found the business.


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Dave Peter Mason
- 35 years old
- Date of birth: Jun 30, 1974
- Date of passing: Feb 14, 2010
|Let the memory of Dave be with us forever
This memorial website was created in memory of our loved one, Dave Mason, 35, born on June 30, 1974 and passed away on February 14, 2010. We will remember him forever.
Memorial Tributes
"Always missed every minute of the day xxxx"
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KXCR Florence's public community radio station invites all dancers to get on their blue suede shoes and enjoy an evening of the best music of the 1950's. It's happening on the back dance floor at the Elks Club on Saturday, October 22, 7PM.
DJ James Bonisteel's amazing collection of discs and vintage vinyl will keep the joint jumpin' and memories flowing. If you remember the 50s you'll know Chuck Berry's 'Johnny Be Goode', The Everly Brothers' 'Bye Bye Love' and Buddy Holly's 'That'll Be The Day' not to mention classics like Nat Cole's 'When I Fall In Love', The Platters' 'Only You', Sam Cooke's 'You Send Me' and, of course, Elvis' 'Heart Break Hotel'. And the list goes on: James Brown, Bo Diddley, Ray Charles, Little Richard, Patsy Cline, Richie Valens, The Coasters and more.
Show up and show off your ducktail and pegged pants or party dress and beehive hair to enter and win costume party prizes. Dance contest and free food treats round out the evening's activities.
$5.00 Door. Beverages sold at the Elks bar.


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Pacific Palisades, California Clinical Trials
A listing of Pacific Palisades, California clinical trials actively recruiting patient volunteers.
Found (3) clinical trials
Study of the application of an investigational device (a suspension of silver pigments) to the skin followed by laser treatment for facial acne
This is a multicenter clinical study to learn about the safety and efficacy of the application of a silver suspension to the skin prior to laser treatment to improve facial acne. One side of your face will have the silver suspension applied before laser treatment, and the other side will ...
2.5 miles
FLUTicasone in Eosinophilic Esophagitis (FLUTE): A Randomized, Double-blind, Placebo-controlled, Dose-ranging, and Maintenance Study of APT-1011 in Subjects With Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is an inflammatory disease of the esophagus, characterized by eosinophilic infiltration and gastrointestinal symptoms. Swallowed, topically acting corticosteroids, such as fluticasone, appear to be effective in resolving acute clinical and pathological features of EoE. APT-1011 is an orally disintegrating tablet (ODT) formulation of fluticasone propionate. This study ...
8.61 miles
Do you have high-risk, localized or locally advanced prostate cancer that requires radiation therapy?
The ATLAS clinical research study is being conducted to assess the safety and efficacy of an investigational medication plus gonadotropin releasing hormone agonist (GnRHa) in subjects with high-risk, localized or locally advanced prostate cancer receiving treatment with primary radiation therapy. The study will enroll 1,500 patients with high-risk, localized or ...
8.63 miles


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"I'm off the Santan…I'm off the Santan…call my b*tch & she gone call her girlfriend…she get off the Santan…can't get off the Santan…all this money, you can call me Band Man…"
King Deazel has released the official visual for his single, Santan. Apparently there's a new substance that helps get the party going called a Santan & King Deazel & his crew enjoys ever bit of it. In the visual, King Deazel & his crew appear to be on some sort of vacation as they enjoy themselves on the beach – with Santans of course.
Watch Santan video directed by Will Gates of Open World Films below:


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Product Controller (Hedge Fund, 3-6 months renewable contract)
Hong Kong
Bullet points
Great working environment
Great training
About Our Client
Our client is a Hong Kong-based hedge fund, established for 10 years in the market. They are looking for a product controller to join their office in Hong Kong.
Job Description
- Responsible for daily P&L (profit and Loss) reconciliation in supporting sales and trading
- Preparing daily reports for Front Office
- Conduct cash reconciliation and provide other operational support
- Handle ad-hoc tasks
The Successful Applicant
- Bachelor degree in Business/Finance or related discipline
- At least 1 year of experience working in Big 4 / Financial institutions
- Must have product control experience
- Immediately available will be considered first Fluent in English, Cantonese, Mandarin would be a bonus
What's on Offer
Potential extension, temp to perm opportunity


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This hotel is situated in the steeply riven Ourika valley, surrounded by Berber villages from which you can hear periodic calls to prayer. The dining is traditional, uncomplicated and yet generally excellent - the couscous was the best we tasted. The Moroccan salad platter was perfectly sufficient for lunch.
We took several short walks (2-3h), guided, at the recommendation of the manager, by Omar, a young man who lives across he road. He speaks very little English and intermediate French but his warm character communicated all that was needed. We visited him at his home which was fascinating - they seemed to be having a lot of fun! Lives are simple in terms of technology but rich in community and landscape. It was interesting to see the women in their domain. Generally your dealings are with men. You'll really miss out of if you don't visit the villages.
The hotel is quite rustic - not a luxury establishment but something more fitting to its mountain environment. We decided the furnishings were "Flintstonesque". The staff were incredibly friendly and concerned for our comfort but also gave plenty of "space". The patron said on our arrival "we are family here, not commercial like Marrakech" and frankly I was sceptical. But in fact it was true! Our bill at the end was exactly correct but they had not charged us for upwards of 20 mint teas, two loads of laundry and even a packed lunch for our trip to Siti Fatma.
The garden is very pleasant as is the pool. In our trips up and down the valley we noticed nowhere nicer. You can pop over the road to buy water and snacks so you don't have to buy everything at hotel prices. We were there in Ramadan and this didn't adversely effect our stay. The hotel is a little rough round the edges but for friendliness, traditional food and mountain location I would highly recommend Ourika Garden.
- Official Description (provided by the hotel):
- Nestled along the valley of Ourika, this intimate inn offers breath-taking views, native-styled guest suites which feature, mountain views, fireplaces, sunset setting, soothing sounds of nature. Looking for a romantic weekend or family adventure, this warm guesthouse combine a heavenly experience with modern amenities. Using vegetables grown in our own organic garden, our skilled chef will custom-make delightful meals, along with serenity and warm set up will ensure you can resource yourself. ... more less


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DETROIT (WOOD) — The Detroit baby for whom an Amber Alert was issued Tuesday has been found.
Eleven-month-old Savannah Rayford is safe, according to Detroit police.
Police say that Savannah's mother, Marquita Dupree, took the baby from her foster parent around 3 p.m. Tuesday. Dupree does not have custody of Savannah.
The National Center for Missing and Exploited Children said that Savannah has sickle-cell anemia and needed her medication. The center also said Dupree has mental health issues.


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Johannesburg - An advisory award for Cricket SA (CSA) indicated that the disciplinary hearing against suspended chief executive Gerald Majola would likely go in its favour, it was reported on Saturday.
The Saturday Star reported that Advocate Johann Myburgh SC, chairman of the disciplinary hearing, provided the award, which implied that he would likely rule against Majola if the case continued.
Mojola, however, wants the process to continue.
CSA acting president Willie Basson told the newspaper that the body now "hold[s] the moral highground."
CSA acting chief executive Jacques Faul stressed Myburgh's findings were not binding.
"The advisory award only gives an indication, and it gives both parties an opportunity to decide whether to withdraw or to go ahead with the full hearing," he said.
"Majola could have resigned, but he has chosen to go ahead and continue with the legal process."
Faul said on Friday he had the backing of the CSA board after he rescinded his resignation.
He initially tendered his resignation last week, citing differences in opinion regarding the roles and responsibilities of the board.
Faul took office after Majola was suspended in March for failing to declare R4.7m in bonuses, which were paid to CSA staff without clearance from the board or the remuneration committee.
Out with Majola
He is just like all the thieving blacks in the country.Corrupt and just here to enrich themselves.
How the hell is it that this ignorant fool just does not understand and wont give up and go fall on his sword somewhere nice and public. Is he that thick skinned or just plain stupid? That he does not realise the cookie has crumbled eventually after all the time he was raping cricket for whatever benefits he could derive for himself. Let's get this over and done with as well and we can move on and try to rebuild after all the harm he has left behind.
Gerald, can you please just quietly piss-off now. You are not WANTED anymore and your 'services' are not needed.
You've already seen to your own golden hand-shake so don't expect any more free handouts.
The cricketing fraternity is way past being gatvol with you. Every time that you attempt to defend yourself, you either pass the buck or blatantly lie.
You will forever be remembered as the midget who stole money and lied to try and cover it up.
What does this stupid Majola think is going to happen?
That a decision will go in his favour or is he hoping that he will be able to use the race card like all bloody thieving ANC members and get away with it by prolonging the inevitable result.


text: By travelling by boat on the Napo there are so much opportunities for visiting distant nature and for enjoying sun and birds while transferring from one place to the other; this is not what you can get in a jungle lodge. The price is equivalent and probably the service as well, but the nature encountering is terrific. The food at... More


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Download The Number Game apk Varies with device free for Android smartphone
Posted by Apps Are Easy in Arcade | March 26, 2015 | 6 Comments
Apk file size: 0 bytes
The Number Game is the ultimate reaction test. Think you know your numbers? Do you have the reaction time to beat your friends? Do you have the endurance to get a high score? The Number Game is a fast paced challenge based strictly on those two skills.
This endless survival game lets you punch in numbers as they come across the screen. At first, things will be easy going and slow. Watch your score climb to 5.. 10.. 15.. but the speed of the numbers will slowly increase. When the numbers hit their top speed, you will struggle to hit the right button. Your mind will be in a frenzy as you see a number and try to remember where the right button is. By the time you remember it?
You're OUT of time.
---How To Play---
*Watch the numbers coming across the screen
*Tap the right tile corresponding to the number
*Don't let the numbers exit the screen
*Don't touch the wrong tile
"This game might be the most fun game I've played in all of 2015. Easy 10/10 in my book. A great training of my reaction skills!" - Made This Up
"Seriously. Play The Number Game. My high score is only about 27, but I promise I'm not gonna let my friends outscore me" - Made This Up Too
"*5*STARS! The Number Game completely blew my expectations out of the water. I played for hours and hours. Crazy test of endurance. Can you beat my high score of 88?" - Made This Up Also
As you can see, people LOVE The Number Game. It's fun, addicting, and really competitive. Don't be that guy who hasn't played it before. Don't show up to school or work and be the only person with no high score on the leaderboards.
What are you waiting for? Hit download!
Whats new
Minor glitch fixes
Apps Are Easy part of our Arcade and have average installs from 50 to 100. Last Update March 26, 2015. Google play rating is 90.0. Current verison is Varies with device. Actual size 0 bytes.
Similar applications
6 Comments
Can't stop playing Once you get past the splash screen issue, it's a great game and I get worked up about it whenever I play. Good game.
David Langbehn
Best game ever Graphics are uber realistic, better than crisis 3 on ultra high with antialiasing on. 9/11 would number again
Bill Hitt
Big Bill Loved game have to be fast n remember where numbers r at very addicting
Mark Wilson
Great game! Very addicting and fun!
Willow Crouch
Keeps saying package file was not signed correctly won't install
Matthew Colburn
Fun and addicting as hell!!!


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- March 2015 (2)
- February 2015 (1)
- January 2015 (5)
What is a Champion Entrepreneur?
About six months ago I had what some might call an epiphany regarding my understanding of success and the implementation of daily activities needed to achieve success. In order to fill my desire to answer the question as to what the difference was between a successful and non successful business man or what we call champions versus non-champions.
I began to heavily research the topic and came across what I consider a startling discovery. There are at least three primary elements which make a Champion and give an individual the ability to become a champion.
These elements are:
- First: Attitude or the mindset and belief structure which individuals have.
- Second: The ability to take action and consistently continue to move forward through actual activities.
- Third: The support and ongoing principle of partnerships through accountability and other person-to-person interactions.
I have come to call these principles: Attitude, Action and Accountability. (I really do not like the fact that they all start with "A" but I keep saying it this way so it has began to stick)
I have found that there is a large amount of resources available to individuals who are looking to take their dreams or beliefs and convert them into motivation, and inspiration as a driving force in their lives. In much the same way, I also found several places where individuals can become connected socially and better their understanding and grow positively through coaches, mentors, mastermind group, partners, business partners, and other person-to-person interaction. The resource I found lacking was that of actionable steps (or the Action) that individual should take to become a Champion in business and in life.
Because of the lack of resources in respect to actionable steps needed to become a champion entrepreneur I decided to launch a podcast dedicated specifically to the ACTION STEPS needed and used to become a champion. I believe that learning from successful and Champion Entrepreneurs is pivotal for achieving success in the business world. By interviewing today's most successful entrepreneurs and asking them what ACTION steps they used to become a champion, you will be prepared to take your inspiration and motivation and put it into ACTION.
I have developed a five day week business podcast that is focused on the action steps individuals have and are you using to move forward. I ask questions such as How to set goals and achieve them? How to finance, market, and organize your new company? What it takes to push through the roadblocks and come out better on the other side? What attitudes and behaviors are key components to achieving long lasting success?
In the words of Stephen Pressfield and his book the War of Art:
"Nothing else matters except sitting down EVERY DAY and trying."
― Steven Pressfield,
I believe wholeheartedly that there's so much more to becoming successful and a Champion BUT don't underestimate the importance taking action! By no means does action equal accomplishment or success yet we will never achieve accomplishment without first taking action.
One Day. One Step.
I really appreciate that you are reading this post.


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It has been seven months since RIM's co-founder, Mike Lazaridis to bring Angry Birds to their PlayBook tablet. Now, the PlayBook has Angry Birds in it. The popular and widely played game, in which the birds attack and destroy the pigs who had stolen eggs with a slingshot.
This game is available on iOS and Android based devices since a long time. The absence of this game in the RIM tablet, PlayBook is the was a sad issue and was a failure to have the customer-friendly apps in it. The PlayBook is actually a device mainly focused on business and it powered by the QNX software.
This tablet from RIM got blistering reviews when it was launched way back in April 2011 but still less then a million units were sold but Apple iPad achieved more than 11 million units sales.
Angry Birds developer, Rovio says that this game has been downloaded over 600 million times despite its absence in the RIM's lineup of smartphones that use the old version of operating system.
The game is available for free in the Apple AppStore and Android Market for the respective devices but when it comes to the Blackberry app world, there are three versions of the game and all the three are available only for a price of $4.99.


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The UpGarden leadership submits the following proposal. This proposal will be voted on by UpGarden plot-holders. Voting starts 9/18 and ends 9/28. An email ballot will be sent 9/18 and paper ballots will be in the trailer/toolshed.
September 18, 2013
Background: During the last months starting on 6-27-2013 there have been several operational meetings discussing open projects from the original build. After working with Laura from the Department of Neighborhoods, it was decided that we still have $11,000 that needs to be spent. Laura wants us to submit the request as one proposal that has been voted on by our garden. The process that we have established is that a proposal is put before the garden and the vote is open for 10 days. Below, you will find the final worksheet that has been put together. Laura has gone over this worksheet and agrees that it would fall under the original plans and could be approved by the Department of Neighborhoods. This work would be funded from the original grant for our build and would not come out of the trust fund. You will notice that the largest allocation is for soil amendment. Laura is very knowable on this issue and will work closely with the garden to meet our needs. The results of the soil testing that has been done will be used in the planning. Laura is also aware that we cannot finish this work by the October 31st deadline, but if we get started by then, that will fulfill that requirement. Also, this is a one year only project, after that any of this type of work will come out of our trust funds are need to be raised. But the cost after this large project is done should not be as high.
If we do not pass this proposal and submit it to Laura by October 15th, we will lose the money. All the project managers on this proposal have been notified that they will need to at least get started and have a working plan by the time. We need a project lead for the cold frame/green house project. The green house or cold frames can be bought if they fit into the budgeted amount and the ascetics of the garden.
Updated: 9-15-13
|Project Name
|Project Description
|Project Lead(s)
|Project Cost
|Soil Ammendment
|Ammend UpGarden soil with needed minerals (loamed soil) and other deficient nutrients, based on soil test results and recommendations; 2X per year, one year only
|Nancy Coe
|Cold Frame/Green House
|NEW cold frame/green house with garden benches for gardeners to grow and protect starts in colder seasons located in one of the original picnic table locations
|Compost Bins Coverings & Worm Bins
|Build compost bin covers for Fall/Winter season to shield compost and support decomposition during cooler months; two composting areas with worm bins
|Julie Sands
|Fall Balance of Plants for Common Beds
|Complete the planting of Fall plants in common beds
|Bonnie Hedman
|Last Raised ADA Bed
|Create one (last) ADA bed utilizing current lumber; may need additional materials (limited lumber, screws, soil cloth lining)
|Raised Common Bed w/ Pollinators
|Create one raised common bed near the picnic table area using any leftover materials from the last ADA bed; may require additional
|Bonnie Hedman
|Bulletin Board & Guest Book
|Outdoor bulletin board to communicate garden news; part of the original plan; materilas include guest book, paint
|Scott Mills
|SPRING 2014; Create and manage bee area, per original plan, includes: building bee enclosure, purchasing bees and bee materials
|Sharon Chan
|Spring Gates & Trellis' Plants
|Plant perenial trellis plants and other filler plants
|Bonnie Hedman
|Sink Installation
|Install sink behind the trailer shed for gardener use
|Scott Mills
|Picnic Tables
|ONE picinic table for one the picnic areas; two picnic tables per original plan


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|1,678 sq. ft.
|Property type
|Minimum Stay
|7 nights
Experience Florida at its best! Apollo Beach is a quiet waterfront boating community where the locals love to relax and watch the sunsets. While beach is in the name the best Florida beaches are a short 45 minute drive south or south and west.
We have three bedrooms, two baths, two car garage, and a huge lanai with a pool. Most of the rooms in the house (even the kitchen) have sliding glass doors which lead to the pool area and offer relaxing views of the water. We have 160' of waterfront with a large dock.
Our home has water views from almost every room. It is at the end of a quiet cul-de-sac. Swim in our 8ft deep pool or just enjoy our 61' screened in lanai over looking the water. The master bedroom has a King sized bed, walk in closet, private bath, TV, and a private entrance to the pool area. Bedroom two has a King bed with
a TV and DVD player and private entrance to the pool. The last bedroom has a Queen bed.
All bedrooms have ceiling fans. The leather couch folds out for extra sleeping space.
We loved the location of the villa. My Husband spent hours fishing off the dock. Of course, the biggest fish got away. Thanks, Jodi for an awesome visit.
This house, location, and amenities were top notch. The kids loved kayaking and fishing from the dock. The adults loved the back porch and the wonderful pool. The location to town was so handy as well. We could not have asked for a better vacation. We look forward to staying with you again.
We had 4 generations staying the first week of August 2013, the house was clean and the kitchen was well stocked. We all loved kayaking in the bay. The pictures are an accurate view of the property. We've stayed in this neighborhood several times, this is a very nice, quite locations.
Still waiting to hear back about our security deposit, other than that we had a great time in Apollo Beach and would recommend the house to others.
What a Great House, Pool and waterway. Only 14 Miles to Down town Y'Bor we went once because the house was so nice just laid around in the pool watching the boats go bye, we had great weather too, found Circles down the Blvd half a mile, Great Food and nice Tiki bar, Bartender, Capt Lori runs a 22 foot boat for fishing charters, great for Thursdays=Sundays. We totally enjoyed our stay and look forward to coming back next year with the Grandkids and my Boat. Jodi I'm glad I got to meet you that one day, Thank You so Much for providing my family and friends such a nice home with a great view and a very nice pool. We'll see you again. Ken, June and Skipper too!
Manatee Viewing, Fishing, swimming, sunbathing, boating, walking (we
have a great neighborhood), ping-pong, golfing, shopping, and so
much more.
We are located just a few minutes from I-75, 10 min from the
beach, 30 min. from Busch Gardens, and 1 hour from Orlando.
Shopping, movies, and a large selection of restaurants are just 15
min. away. If you choose to remain in the area, you can find
fabulous food and harborside dining at Circles, our favorite
waterfront indoor/outdoor
dining spot in Apollo Beach.
|Pet Fee
|Cleaning Fee
|Refundable damage deposit
|Tax Rate


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Is this girl fat?
Have an opinion?
What Guys Said 30
little chubby but not fat55|01|0
definitely chubby. on the edge in my opinion.33|00|0
yes, she's fat.42|20|0
Not fat but if cardio isn't done soon she could end up "fat". My term for fat is when you can't normally see your toes standing up and looking down.00|03|0
She looks fine. 🙂11|00|0
No I don't think about other people.11|00|0
She is not bad just needs toning more than anything else00|01|0
Hella fat, yep21|10|0
Yes, she is.11|00|0
Yes, chubby need to improve unless she is very athletic or body builder00|00|0
Yes, but all she has to do is loose weight and she will be even more confident of she's lacking self confidence :))))00|00|0
Yes she is overweight00|00|0
PC version: She's plump.
Non-PC version: fat.00|00|0
She could do with losing some weight00|00|0
No she is chubby.00|00|0
A bit. So?00|00|0
On the verge of being fat, but really chubby00|00|0
Yes, definitely.00|00|0
Yes she is00|00|0
Yes she is00|00|0
No no no no!00|00|0
In all honesty, yes00|00|0
Yes she's fat.00|00|0
Her top half is fine just a bit chubby, but I think she could lose some weight around her thighs and bum :p Seems that's where most of her weight has gone.00|00|0
Goddamn so many white knights on this site. She's overweight, fat. Not chubby. Not chunky. Not thick.62|41|0
No. To me, she is not skinny, but not fat either. I like that body shape personally. Sexy hips and curvature from what I can see. Not skinny does not mean fat. Medium build=hot to this guy.11|02|1
What Girls Said 23
No she isn't.11|00|0
She's chubby but she looks okay..11|00|0
No, she's just chubby. I don't think anyone is fat until they need to pay for an extra seat on a plane so the other half of their body can fit.11|00|0
very chunky..00|00|0
She's chunky but not fat yet.00|00|0
She's fat
chubby I say00|00|0
Yes she is overweight00|00|0
Kind of. I think she's more chubby than really fat.00|00|0
Pretty heavy set. So.. yea.11|00|0
Looks a little over weight maybe, wouldn't call her fat though.00|00|0
I wouldn't say fat, but not skinny either00|00|0
She almost is, but very chubby00|00|0
Nope 😜😜😜00|00|0
I dont know about fat because her body type is wide00|00|0
Yes maybe...00|00|0
Yes she is00|00|0
More cushion for the pushin.
More to love.
She's not obese or anything but she's definitely on the chunky side. But she has a super cute outfit on.00|00|0
I would say she is curvy. she's not enormous but definitley not skinny00|00|0
Yes, she is fat.11|00|0
Eh, she's definitely a bit overweight. But that's ok :)00|00|0
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Colorful Shell Note Cards
Beautiful water colored sea shell on a pastel background graces the front of these note cards. There is a small copy of the shell on the lower right on the inside with plenty of room for letter writing. Our note cards measure 4 1/4 inches by 5 1/2 inches and are printed on 100% eco friendly card stock. Perfect for letter writing and also makes a great gift!
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Weird Ways to Save Money
You always hear of the conventional ways to save money, but what about the unconventional ways? I mean we all know we will save money if we stay in our houses and do not leave, but we want to live, right? I was thinking of some unconventional ways to save money, so we can enjoy our budget a little more and stop stressing about money.
K is for Kicking Back and Relaxing to Rejuvenate Yourself
In order for you not to become burned out, you have to incorporate time for kicking back and relaxing to rejuvenate yourself. Work at home mothers are in no way immune to the stresses of a work environment, such as deadlines and a heavy workload. In fact, they may become more stressed and overwhelmed at times, because they are working and providing their own childcare. Try these simple relaxing tips and unwind for a while.
You Are Never Too Old For a Bubble Bath
Categories: All Blog Posts, Our A-Z Posts Tags: family, fun, getting relaxing, refreshing, rejuvenation, spending time together, spending time with family
A Few Gardening Tips From the Mum
Gardening time is here, well in most parts of the world. If you are anything like me, then you appreciate fresh fruits and vegetables from you own garden. It is one thing to grow a garden, but it is another to actually produce consumable vegetables and fruits. One of my ultimate past times is to see pictures of other people's gardens. There is something invigorating and refreshing to know that people are getting back to growing their own food. Are you an avid gardener or do you think you will ever garden?
Categories: All Blog Posts, Garden Tags: family, flowers, Garden, gardening, gardening and fun, gardening in the summer, grass, husband, kids, permission, spending time with family, vegetables, yard
J is for Just Spending Time With Your Children
One of the great things about being a work at home mom is just spending time with your children. This is truly a luxury many moms that have out of the home traditional job simply do not have. This is the main reason there are more and more WAH professionals: Family. Mothers and fathers that are out of the home and have to rely on daycare and babysitters miss out on most of their children's first milestones, such as walking and their first words. In addition, the cost of childcare has not gotten any cheaper even though the economy is poor. So, when you combine the two, many mothers are left with only one logical option and that it to work and be at home with their children.
I is for Initializing a Conversation with Other Work at Home Professionals
As a work at home mom, it is important to have contacts who are other work at home professionals. You may need to have assistance with a project or need a reference for one of your clients. These contacts are also a great place to ask about new leads or advice. There are several places to get in touch and start initializing a conversation with other work at home professionals. There are all sorts of online places you can go to get in touch with the work at home community and several are dedicated to mothers. The following are three places to initializing a conversation.


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electronic card
- A digital greeting card sent over the Internet. There are many applications and Web sites which can be utilized to prepare such cards, and such greetings may incorporate text, still images, video, animation, audio, and so on, and can be chosen for virtually any occasion or purpose. Its abbreviation is e-card. Also called electronic postcard, digital postcard, or virtual card.
- abbreviation e-card
- abbreviation ecard
- synonym electronic postcard
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