text:
Tiddler is another gem of a book by the marvellous duo of Donaldson and Sheffler. It captured the imagination of our grade twos and had them wanting more.
Tiddler is a little fish who likes to tell big tales. Every day he arrives late for school and every day he has an elaborate excuse for his tardiness. These tales involve octopuses, shipwrecks and turtles and the stories spread like wildfire from one fish to another and another. One day, Tiddler is on his way to school when he is so distracted by his daydreaming that he gets caught up in the net of a fishing boat. He eventually gets thrown back in the water and finds his way back to school when he hears some anchovies talking about one of his stories. He tracks the story back home and arrives at school just as everyone else is leaving. Tiddler explains what happened and of course not everyone believes him, but still his story spreads until it is told to a writer, which is how the book is written.
This is a book which celebrates the power of storytelling. It would be great inspiration for a creative or imaginative writing session.


text:
A soundtrack album has been released for the thriller Bad Kids of Crestview Academy. The album features the film's original music composed by Jeff Cardoni (Mike and Dave Need Wedding Dates, Silicon Valley, CSI: Miami, Just Friends, Speechless). The soundtrack is now available to download on Amazon, where you can also listen to audio samples. Bad Kids of Crestview Academy is directed by Ben Browder […]
Posts Tagged 'Ben Browder'
'Bad Kids of Crestview Academy' Soundtrack ReleasedPosted: January 3, 2017 by filmmusicreporter in Film Music Albums
Tags: Bad Kids of Crestview Academy, Ben Browder, Jeff Cardoni, score, Soundtrack

subset: commoncrawl


text:
Last night I went to a high school football game for the first time since I was a sophomore in high school, back in Lake Havasu City, Ariz. I never attended a football game at the California school where I attended my last two years of high school, and haven't attended one since. Haven't had a reason to. But last night Pam's niece, Kelsey, was playing the sousaphone in the Whitco marching band, and since Pam's Mom and step-dad were out from California, we all went.
They honored the Whitco team that won the state championship 20 years ago. Probably 40 players from that team, along with coaches and various other personnel, including five cheerleaders, were lined up in front of the home crowd during halftime, and the announcer read off information about each one–name, the person's position/role in 1986, where the person lives now, and where he/she works. I was amazed that the vast majority of them still live in the general area, with a large number still in South Whitley. Interesting. Only one guy was wearing his letter jacket, or could fit into his letter jacket, and he was serving in the military in Alabama.
Beyond that, I have no great insights to share. No wise ruminations about then-and-now, how sports brings a small town together, kids today vs. in my era, and nonsense like that. So I'll stop.1 Comment


text:
1.4 / November 24, 2016
App Information Đào Vàng Tây Du Ký
- App NameĐào Vàng Tây Du Ký
- Package Namecom.xsl.td
- UpdatedNovember 24, 2016
- File SizeUndefined
- Requires AndroidAndroid 4.0 and up
- Version1.4
- DeveloperĐào Vàng Cổ Điển
- Installs50,000 - 100,000
- PriceFree
- CategoryCasual
- Developer
- Google Play Link
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--> NOW WITH THE ROULETTE SYSTEM! <--Combination of counter strike case simulator with clicker.Click, buy keys and open cases! Be the best!What can be found in the game?— Arm deal contracts, just like in real Counter Strike!— Roulettes and Online Jackpot system!— Match betting system - place bets on real matches!— Jackpot & trading system!— Over 200 achievements— Rank system, from silver to global elite!— Mission system— Souvenir system— Capsules with stickers— Over 250 upgrades— Over 700 obtainable skins!— Over 600 obtainable stickers!— Ability to sell skins for real market pricesAnd much more!
Plants vs. Zombies™ 2 6.5.1 APK
Read on for important info below!"As beautifully presented as it is absorbing to play: 8.7 out of10." – ign.comPlay the award-winning hit action-strategy adventure where youmeet, greet, and defeat legions of hilarious zombies from the dawnof time, to the end of days. Amass an army of amazing plants,supercharge them with Plant Food, and devise the ultimate plan toprotect your brain.100 Million Downloads – This app has received more than 100 millionoverall downloads.Winner: Best Mobile Game at E3 – Game InformerWinner: Best Mobile Game 2013 – MashableWinner: Game of the Year 2013 – Slide to PlayDISCOVER HUNDREDS OF PLANTS AND ZOMBIESCollect your favorite lawn legends, like Sunflower and Peashooter,along with hundreds of other horticultural hotshots, includingcreative bloomers like Lava Guava and Laser Bean. Gotoe-to-missing-toe with a massive array of zombies at every turn,like Jetpack Zombie and Mermaid Imp – you'll even have to protectyour brain from rampant Zombie Chickens!GROW POWERFUL PLANTSEarn Seed Packets as you play and use them to fuel your plants likenever before. Power up attacks, double-down defenses, speed upplanting time, and even gain entirely new abilities. Boost yourplants to ensure those zombies are lawn-gone!JOURNEY THROUGH SPACE AND TIMEBattle across 11 crazy worlds, from Ancient Egypt to the FarFuture, and beyond. With more than 300 levels, ultra-challengingendless zones, fun mini-games, and daily Piñata Party events,there's always a new challenge to complete. Plus, ready your bestdefenses – Dr. Zomboss is waiting to take you on at the end ofevery world!EXPLORE MORE WITH THE TRAVEL LOGStumped about where to go next? Consult your Travel Log to embarkon exciting Quests created just for you. Complete Scheduled Questsbefore time runs out, or take on a series of Epic Quests and earnspecial rewards.Requires acceptance of EA's Privacy & Cookie Policy and UserAgreement.By installing this game, you consent to its installation and theinstallation of any game updates or upgrades released through yourplatform. You can turn off automatic updates through your devicesettings, but if you do not update your app, you may experiencereduced functionality.Some updates and upgrades may change the way we record usage dataand metrics, or change data stored on your device. Any changes willalways be consistent with EA's Privacy and Cookie Policy, availableat privacy.ea.com. You can withdraw your consent at any time byremoving or disabling this app, visiting help.ea.com forassistance, or by contacting us at ATTN: Privacy / Mobile ConsentWithdrawal, Electronic Arts Inc., 209 Redwood Shores Pkwy, RedwoodCity, CA, USA.
MegaN64 (N64 Emulator) 6.0 APK
MegaN64 is a very fast N64 emulator. Play yourfavorite N64 games on your phone!You need to place your own game files onto the SD card beforerunning this N64 Emulator.MegaN64 is a modified version of the Open Source projectMupen64+, which is licensed by GNU GPL v3. Modifications includeperformance enhancements for specific Phone Models such as theNexus 4 and the Galaxy S4 and small UI improvements.If you like MegaN64, please donate to the developers of Mupen64+by purchasing the app here:https://play.google.com/store/apps/details?id=paulscode.android.mupen64plusFor the license, visithttp://www.gnu.org/licenses/gpl-3.0.html
LINE Get Rich 2.2.0 APK
Pets in Get Rich?! Take the lead in the newPet Lead Map!Claim power and riches on a scenic beach!Become a pet owner on the map and take the advantage with yourpet's help!Construct extra buildings or make mini pets! Your pet will evenhelp you get Landmarks!Now with 14 maps to take on, and infinite ways to strategize andplay!Look out for hot beach battles on the all-new Pet Lead Map!- Travel virtually, and share exciting adventures with yourfriends! -Team up with your friends, and become financial masters!Are you ready for an exciting adventure?C'mon! Call your friends and family, and become the master of theboard!- Travel the World, discover Space, and have tea with the gods!-Construct Landmarks around the World!- Feel the thrill of taking over your rival's properties! -Roll the dice, and spread your empire to infinity and beyond!Choose your cards carefully, and roll the dice to become a real GetRich mogul!- Tons of unique, and awesome characters! -Meet Alice, the hot-headed warrior, Wolf Beauty Chihiro, the toughzombie hunter Fran, or Genie from the Lamp!Team up with these lovely characters to reach the top!- Fortune Cards! -With the help of Lady Luck, you may turn things around with justone Fortune Card!You can spread viruses on your rival's properties, decrease thevalue of their properties, or even force them to exchange theirpriced properties! Time to plot, you sneaky genius!- Travel virtually, and share exciting adventures with yourfriends! -Team up with your friends, and become financial masters!Are you ready for an exciting adventure?C'mon! Call your friends and family, and become the master of theboard!
My Talking Tom APK
Discover the #1 games app in 135 countries!Adopt your very own baby kitten and help him grow into a fullygrown cat. Take good care of your virtual pet, name him and makehim part of your daily life by feeding him, playing with him andnurturing him as he grows.Dress him up any way you like and pick from a wide selection of furcolors and other accessories. Decorate his home and travel theworld to meet other Toms. Play mini-games and watch as Talking Tombecomes part of your everyday life.FEATURES: - Play over 10 mini-games: Happy Connect, Bubble Shooter, BrickBlast and more! Earn gold coins and have fun!- Nurture your very own Tom: Play games with him, feed him hisfavorite foods, tuck him into bed. - Collect flight tickets and travel around the world to meet otherToms. Fill your album with postcards from different places andunlock clothes fit for a true adventurer.- Enjoy life-like emotions: Tom can be happy, hungry, sleepy,bored... his emotions change according to how you play withhim. - Unleash your creativity: Create your very own Tom by choosingfrom 1000's of combinations of furs, clothing andfurniture. - Get rewards as you progress: Help Tom grow through 9 differentstages and 999 levels unlocking new items and coins as yougo! - Interact with Tom: Talk and Tom still repeats everything you say.Poke, stroke and tickle him, and watch how he responds.This app is PRIVO certified. The PRIVO safe harbor seal indicatesOutfit7 has established COPPA compliant privacy practices toprotect your child's personal information. Our apps do not allowyounger children to share their information.This app contains:- Promotion of Outfit7's products and advertising- Links that direct customers to our websites and other Outfit7apps- Personalization of content to entice users to play the appagain- The possibility to connect with friends via social networks- Watching videos of Outfit7's animated characters via You Tubeintegration- The option to make in-app purchases- Items are available for different prices in virtual currency,depending on the current level reached by the player- Alternative options to access all functionalities of the appwithout making any in-app purchases using real moneyTerms of use: http://outfit7.com/eula/Privacy policy: http://outfit7.com/privacy-policy/
Angry Birds 2 2.17.2 APK
Get Ready for the Holidays with Google Play'sFestive Updates!Join hundreds of millions of players for FREE and start your AngryBirds slingshot adventure now! Team up with your friends, gather inclans and take on challenges and events in the all new game modes.Are you ready to evolve your birds and show your skills in the mostdaring Angry Birds game out there?CHOOSE YOUR BIRD!It's the ultimate slingshot strategy – YOU choose which bird tofling next! "But that makes it easier, right?" WRONG! You'll needto choose wisely if you're going to stop those eggs from gettingscrambled. Plus, destroy blocks to fill up the Destruct-O-Meter andearn extra birds!NEW MULTI-STAGE LEVELS!You've never seen Piggy Island like this – jaw-droppingly stunninglevels brimming with exotic plants, quirky details and plenty ofperil. And because those naughty porkies are building theirteetering towers right under your beak, many levels have multiplestages. Uh oh.SPECTACULAR SPELLS!Blizzards, Hot Chilis, Golden Ducks and other outrageous spellsgive you an added advantage against those swindling swine. And whenyou need some serious help, guess who's at hand to make apork-smashing cameo? That's right, it's the sardine loving MightyEagle. Oh yeah!CHALLENGE OTHER PLAYERS!Challenge players from across the world in the Arena to see who'sthe most hardcore bird flinger of them all. Play new tournamentsevery day, earn feathers to level up your birds and face offagainst the toughest competition on the planet. Game face!DEFEAT BOSS PIGGIES!There's some serious bad guys on Piggy Island, and your slingshotskills are needed to take them down. Foreman Pig, Chef Pig and theinfamous King Pig will stop at nothing to keep your eggs. Are yougonna let 'em get away with that? It's time to teach the pork alesson.-----------------------------Discover:https://www.angrybirds.com/Follow:https://www.facebook.com/angrybirdshttps://twitter.com/AngryBirds-----------------------------Angry Birds 2 is completely free to play, but there are optionalin-app purchases available. Either way, get ready to raindestruction on those swindling swine!This game may include:- Direct links to social networking websites that are intended foran audience over the age of 13.- Direct links to the internet that can take players away from thegame with the potential to browse to any web page- Advertising of Rovio products and also products from thirdpartiesThis game may require internet connectivity and subsequent datatransfer charges may apply. When the game is played for the firsttime, there is a one-off download of additional content.Terms of Use: http://www.rovio.com/eulaPrivacy Policy: http://www.rovio.com/privacy
Plants vs. Zombies 2 6.5.1 APK
"As beautifully presented as it is absorbingto play: 8.7 out of 10." – ign.comPlay the award-winning hit action-strategy adventure where youmeet, greet, and defeat legions of hilarious zombies from the dawnof time, to the end of days. Amass an army of amazing plants,supercharge them with Plant Food, and devise the ultimate plan toprotect your brain.100 Million Downloads – This app has received more than 100 millionoverall downloads.Winner: Best Mobile Game at E3 – Game InformerWinner: Best Mobile Game 2013 – MashableWinner: Game of the Year 2013 – Slide to PlayDISCOVER HUNDREDS OF PLANTS AND ZOMBIESCollect your favorite lawn legends, like Sunflower and Peashooter,along with hundreds of other horticultural hotshots, includingcreative bloomers like Lava Guava and Laser Bean. Gotoe-to-missing-toe with a massive array of zombies at every turn,like Jetpack Zombie and Mermaid Imp – you'll even have to protectyour brain from rampant Zombie Chickens!GROW POWERFUL PLANTSEarn Seed Packets as you play and use them to fuel your plants likenever before. Power up attacks, double-down defenses, speed upplanting time, and even gain entirely new abilities. Boost yourplants to ensure those zombies are lawn-gone!JOURNEY THROUGH SPACE AND TIMEBattle across 11 crazy worlds, from Ancient Egypt to the FarFuture, and beyond. With more than 300 levels, ultra-challengingendless zones, fun mini-games, and daily Piñata Party events,there's always a new challenge to complete. Plus, ready your bestdefenses – Dr. Zomboss is waiting to take you on at the end ofevery world!EXPLORE MORE WITH THE TRAVEL LOGStumped about where to go next? Consult your Travel Log to embarkon exciting Quests created just for you. Complete Scheduled Questsbefore time runs out, or take on a series of Epic Quests and earnspecial rewards.Requires acceptance of EA's Privacy & Cookie Policy and UserAgreement.
Stickman Warriors 1.5.3 APK
Stickman Warriors - fun and addictivebeat'em'up game with realistic physics and hardcore gameplay. Withsimple controls you can perform amazing stunts and blows to defeatyour opponents.Features:- amazing stuns- realistic ragdoll physics- several campaigns- exclusive soundtrack- hardcore gameplay for mature gamers


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Nine die as landslide derails commuter train in Italy
NINE people were killed when a landslide derailed a commuter train in northern Italy yesterday.
The two-car train, filled with local commuters and students, was passing by at the exact moment that a large irrigation pipe on higher elevation burst near Merano, 300km north of Venice in the Italian Alps.
"A mass of mud and water knocked down the first car into the ditch," said local official Francesca De Carlini.
"All of the dead were in the first car, which was pulled down into the ditch."
She discounted earlier media reports of the possibility of three missing, saying that the death toll was definitive at nine.
There were also 28 injured, including seven hospitalised in serious condition, Ms De Carlini said.
A geologist was examining the terrain, but it was not clear why the pipe burst, she said. A magistrate has begun an investigation into the cause, but the rupture didn't appear to be due to cold weather.
Ms De Carlini said that the accident occurred shortly after 9am and that help arrived within a few minutes. Helicopters, ambulances and firefighters rushed to the scene.
The train had been nearing its destination of Merano after departing from the small town of Malles. The train line runs between the Adige river and mountains.
The accident is the biggest in Italy since 31 people died in June 2009 in the Tuscan city of Viareggio, after liquefied petroleum gas spilled by a derailed freight train exploded at a railway station.
Irish Independent


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Roasts are not just for special events or holidays. They can be a great dish that can spread across a couple of meals, especially if you're in a smaller household like we are. With Thanksgiving right around the corner, there's no better time like now to plan for how to deal with those leftovers! We've got a plan in place to make you go #OMGardein, using the Gardein Holiday Roast!
The Gardein Holiday Roast is one of the best vegan roasts we've had, and it's quick and easy to make! You can cook from frozen and all will be ready in about 60-75 minutes. The gravy packets only require steeping in hot water. Nothing more is needed, unless you want to do more.
What we really enjoy about the roast are the breadcrumb coating and the cranberry and wild rice stuffing. They really put the "holiday" in Gardein Holiday Roast. Not to mention, the roast itself is juicy and tender, which may seem odd for something made of soy protein and vital wheat gluten. There's a lot of flavor in there! Yup, #OMGardein
Sorry, if you're gluten-free, but Gardein does offer a number of gluten-free option in its line!
Gardein Holiday Roast nicely serves up to 8 and comes with 2 gravy packets! So, there may just be plenty for everyone to make your holiday compassionate and cruelty-free. If not, a second roast won't hurt you. Compared to others on the market and the animal kinds, you can't beat a price of around $14.99 for this roast!
If you're lucky to have leftovers (or have a second roast on hand), we found a great way to enjoy them in a fun way…DIY Holiday Leftovers Sandwiches. This may seem like a lazy recipe, which it is, but who wants to put in any additional effort after a busy week or a massive family feast? So, here we go! It really is an anything goes type of creation!
- 8 sandwich rolls or 16 hearty slices of bread
- 1 Gardein Holiday Roast, cooked according to package
- 2 pkts. Gardein Holiday Roast gravy, prepped according to package
- 2 c. whipped sweet potatoes* (Carlo has one for you, if you want to try!)
- 1 c. your favorite cranberry sauce
- 1 c. greens
- 1 c. vegan mac & cheese
- 2 medium sweet potatoes
- 1/4 c. vegan butter
- 1/4 c. maple syrup
- 1/4 tsp. dried sage
- Salt & black pepper to taste
- Toast your sandwich rolls or bread slices
- Slice Gardein Holiday Roast into 8 equal portions. Then slice each portion in half
- Assemble each sandwich as follow: 1/4 c. sweet potatoes, two slices of roast, spoonful(s) of gravy, cranberry sauce
- If adding other leftovers, be sure to add them before the cranberry sauce and top part of roll or slice of bread
- Enjoy, especially while in front of the TV in pajamas!
- Rinse potatoes and prick skin with a fork
- Microwave for approximately 7-10 minutes
- Push ends together of each potato to open them
- Scoop out the potato into medium bowl
- Add the remaining ingredients and whip with a fork or whisk until smooth
- You really can add anything you like to this. Carmella would highly recommend some mashed turnips. Carlo would throw in some spicy peppers (of course). Have fun!
- Playing with your food is always encouraged!
Need some ideas for your holiday feast…and leftovers…see what Gardein has to offer! There are some quick and easy meal ideas to go along with your Gardein Holiday Roast and other seasonal items!
Hungry for that sandwich? Yeah, us too! #OMGardein!
Question: What's your favorite way to enjoy the holidays…and the leftovers? Share with us in the comments!


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19 Items
- Solar Energy Science Kit Item # P6-7000$10.50 As low as $10.00QuickviewUse this simple apparatus to design an experiment to test the usefulness of solar energy cars in your climate! Kit includes 0.5V, 500mA photovoltaic cell, motor, and diffraction foil disk. Read More
- Photon Solar Racer Kit Item # 11-0048$24.95Quickview
This Solar Racer Kit can travel an average of 10-ft. in three seconds on a smooth, flat surface when exposed to full sunlight. Sleek, transparent body looks great as is, or add your own custom paint job.Read More
- Wind Turbine Kit Item # P6-7500$119.00Quickview
This wind Turbine Kit is a miniature real-working wind turbine (wind power generator) designed for students to evaluate the pitch (setting angle) of the profiled blades. Learn how the number and pitch of blades affect the power output of the wind turbine.Read More
- Horizon Energy Box Item # P8-3500$1,149.00Quickview
The Energy Box is full of topic-specific kits including the Wind Turbine Kit. More than 100 experiments, using 54 items, can be performedRead More
- Fuel Cell Car and Experiment Kit 10 Item # P6-6005$179.00 As low as $169.00Quickview
Fuel cells are one of the most promising means of producing energy in the future. Every major automaker is developing fuel cells. Now your students can experiment with this cutting-edge technology!Read More
- 6 In 1 Solar Kit Item # 11-0083$21.95Quickview
The 6 in 1 Educational Solar Kit teaches kids the benefits of solar energy while they create a toy that is great fun. An excellent beginner building kit designed to teach how solar power is used to drive a small motor.Read More
- Rocket Car Experiment Kit Item # P6-6024$19.95 As low as $17.95QuickviewFuel the Rocket Car Experiment Kit with baking soda and vinegar, insert the fueling module, and your land speed challenger will be ready to roar off. You'll see chemistry and physics in a new light after racing a Scientific Explore Read More
- Power House Item # P6-6014$99.00 As low as $89.00Quickview
The Power House provides an engaging introduction to alternative energy sources while demonstrating basic concepts and principles of physical science.Read More
- Snaptricity Item # P6-1555$42.95 As low as $38.65QuickviewLearn about the relationship between electricity and magnetic fields, how switches control the electricity to the lights in your home, how series and parallel circuits affect the flow of electricity, and so much more. 75+ experiments! Read More
- Renewable Energy Education Set Item # P4-2023$249.00QuickviewUse endlessly renewable solar power to create hydrogen fuel from water and learn the workings of a renewable energy system from start to finish. Explore clean energy sources and fuel cell technology. Read More
19 Items


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Good day to you!
Quick update.
I've finished the first draft of Part 1 of Space Danger! Hooray!
It took many days and many beers as I used my local pub The Tiger to write it in. A few hundred words at a time whenever I could. Took bloody ages! But now the slow process has finally succeeded and I am a solid quarter through the whole four part pulp space epic type thing.
Work has started on Part 2 already but Part 1 is going to go and sit in a dark place for a while before I smack it about with the editing sword.
Hopefully before too long it will be edited, proofed, beta read, smacked about a bit more and be out in the world ready for your electronic book reading device.
But for now… Be careful in space. There's danger in it.


text:
I am an engineer, tinkerer, ranter and an occasional complainer. Kuzyatech is a place where I show off my latest projects, "discoveries" in the world of electronics or simply rant on random topics. Vintage electronics, any kind of test gear, display technologies, solar and EVs are just some of my interests.
I do occasionally work on freelancing projects that are interesting for me personally. Here are some of the projects I've worked on in the past. If you need a design or layout done in Altium Designer or DipTrace- contact me.


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|Professional Automotive Repair Technical Discussions for February 2, 2012
International Automotive Technicians' Network (iATN) - Members Only
|(Also Available: All, Asian, Chrysler, European, Ford, GM.)
|Vehicle Owners: If you are seeking an automotive repair professional to service your vehicle, visit the iATN Repair Shop Finder.
Open Help Requests for Asian
|Help Request
|1999 Honda Odyssey EX 3.5L traction contrl VIN: 2HKRL1863X
traction control light on scanned for codes ...have code # 31-02 PFINH signal failure ??? can any one explain this i have no reference material for this thanks
|2002 Hyundai XG350 3.5L Hesitation VIN: KMHFU45E82
Thanks for everyones help in advanced. We had this car origonaly for replacing timing belt did that car left everything good about 2 months later customer took in to diff. shop complaining car would just die periodicly but allways restart that shop looked at i...
|2000 Isuzu NPR 5.7L Hesitation, Cuts out, Misfire VIN: 4KLC4B1R3Y
I don't have any wiring diagrams for the fuel pump circuit, so that's a problem. The vehicle just came back, same complaint, hesitates under load, can't maintain freeway speeds. Ran a new power supply from battery to relay box (on driver's side), and from rela...
|2004 Kia Amanti 3.5L Speedo VIN: KNALD12434
This car came in with speedo and cruise inop. No speed signal to computer. I raised the car and checked the power and ground to the VSS Sensor both good. No output from VSS. The VSS is gear driven. I pulled the sensor to check the drive gear. Good. Turned it b...
|2008 Kia Rondo LX 2.7L Misfire VIN: KNAFG52658
I am looking for firing order for the number 5 cylinder alldata tells you the firing order but not give location thanks for your help
|2002 Lexus RX300 3.0L MIL Lamp on, p0440 VIN: JTJGF10U02
Hi guys, Thank you in advance for any help that you can give. This one is kicking my but and I really need some advise. Car came in with a p0440 and a p0446. I found a bad vsv on the canister, So I replace canister. Mistake 1, did not smoke. Car came back 3 d... Trouble codes: P0440
|2005 Lexus GX470 4.7L MIL Lamp on VIN: JYJBT20X45
Cleared codes. [...] back days later. Can't test any other parts without removing upper intake. Is there a common problem in this system such as the air switching valve no 2 (asv no 2) (bank 2) that is possible stuck? Dealer wants to replace 3 valves, gask... Trouble codes: P1442, P1445
|1997 Mazda 626 DX 2.0L Poor Idle Quality, Surge, Stall VIN: 1YVGE22C9V
This car came to me from a used car lot after another shop put a head gasket in it. They don't know how it was running before the repair because they bought the car with the "headgasket problem" so I don't know how it was running before that repair. I have got...
|2000 Mazda Protege ES 1.8L MIL Lamp on VIN: JM1BJ2211Y
Need some help guys, p0401 keeps comming on, first checked passages and checked ok, found faulty egr and replaced. Light came back on 2 days later same code. Have checked boost sensor and boost sensor solenoid and both check ok. wiring to ecm are good.When i l... Trouble codes: P0401 (EGR insufficent)
|2001 Mitsubishi Eclipse GT 3.0L p1603 VIN: 4A3AC84H31
Vehicle has come back twice with a check engine light and code P1603 Battery Backup Circuit Malfunction (Mitsubishi) P1603, We have check all fuses and ground to the battery. Car runs fine but does seem to idle higher than normal.
|1996 Nissan Altima GLE 2.4L stuck in 2nd VIN: 1N4BU31D1T
hi all.got this altima in for a shifting problem.it takes off in second gear and stays there.even if you try to manually shift it stays in second gear.no passing gear.had code po1605 for a/t comm line error.tested comm line for continuity between the ecm and p...
|2000 Nissan Xterra SE 3.3L Oil Leak VIN: 5N1ED28T9Y
Vehicle was brought in with oil pouring out on the ground. The valve cover gaskets were obviously leaking. After replacing them (they were hard and broken), it still leaked on the left side. And if you let it run for a while, it started smoking out the exhaust...
|2004 Nissan Patrol 3.0L pipes
The ABS system on this car has been removed. Need a diagram (plumbing map?) to refit the system
|2001 Toyota Celica GT 1.8L MIL Lamp on
car came in with cel on and code p0171 system lean.see freeze frame data is in "testing and results" below.i know these maf's can have issues with codes and no symptom, so after checking for intake leaks and 02 sensor i replaced it with a toyota oe maf sensor ... Trouble codes: P0171
|2001 Toyota Sequoia SR5 4.7L converter? VIN: 5TDBT44A91
As soon as it is put into reverse or foward the engine dies. Almost feels like if you let the clutch out to fast, (this is an automatic). Are these known for torque converter problems. There are no codes for engine or trans. Are these known for this, I found n...
|2003 Toyota Sequoia Limited 4.7L starter VIN: 5TDBT48A93
Hello there I have this Sequoia here and the cust was towing a dump trailer and the batt was installed incorectly and when he stopped and went into a lumber store and came back out he saw the utility box smoking from the battery touching the metal sides of the...
|2007 Toyota Matrix XR 1.8L tachometer VIN: 2T1KR32E27
Tach had been intermittantly fluctuating from 0 to 8000 rpm at idle. After cluster replacement now fluctuates 0 to 3000 rpm while engine is at idle when first started hot or cold. Scanner shows rpm around 900 rpm with little fluctuation. very little info on ta...
Fixes & Summaries for Asian
|1990 Acura Legend LS 2.7L No Start, Stall VIN: JH4KA4673L
It's been over a week since I informed the owner of what I found and haven't heard a thing from them. I did check for codes and it only has code 14 (Idle Control) I did check the crank / cam sensor and found no signal coming from it. I informed the owner an...
|2006 Hyundai Santa Fe GL 2.4L Hesitation, Cuts out, Stall VIN: KM8SB12B86
Thanks for all the replies. It was the Crank sensor, I put my voltmeter on a few circuits to see in any dropped out on a test drive. Got about 2 minutes into my drive when it stalled at a light and wouldn't re-start. Got code P0338 for crank position sensor... Trouble codes: P0134.
|2004 Infiniti G35 X 3.5L power window
The re-set procedure that was suggested by Luke fixed the problem. Thank you!
|2007 Infiniti FX35 3.5L No Start, Cuts out, runs on ether VIN: JNRAS08W07
Thanks for the replies guys, got the flu this week, but managed to fix this one, just hadn't logged on here yet. Had I been more on the ball I would have unplugged the MAF before I thought I needed help. As it turns out Chris' is spot on. Put in a new MAF and ...
|2007 Nissan Versa SL 1.8L speedometer not working. uses CAN & ECM. VIN: 3N1BC13E37
thank you guys, really appreciate the quick responses! Closed with fix. Suggestions were to scan while driving, checking vehicle speed: there was none, 0 mph. I checked wiring again and found the problem. FIX was the harness connector at left fender above whee...
|2004 Subaru Outback 2.5L Mechanical VIN: 4S3BH67574
So the consensus was that it was an axle problem, well the customer is gonna tolerate it until it gets worse so I do not have a fix because at this time it has not been fixed. Thanks to all who replied.
|2006 Subaru Outback 2.5i 2.5L parking lights VIN: 4S4BP61C16
The parking light switch was faulty. I found the Mitchell electrical diagrams difficult to follow and the Subaru ones were worse. At the parking light switch I had 12v at the white wire and turning on the switch gave me 12v to the orange wire and 12v at fuse ...
|1998 Toyota Tacoma DLX 2.7L starts hard cold VIN: 4TAPM62N9W
Customer took the truck, when I get it back I will go back to the basics and test compression. thanks for your help everyone!


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Michael Ferrier writes: Stop the insanityPOSTED: 10/5/15 6:08 PM
Five governments in five years – that is Country St. Maarten's claim to fame, and all because we keep trying to work an electoral system that does not and will not function. As long as there are politicians who enter the political arena, who do not mean what they say, do not keep their word, do not know how to practice country above self and who will do whatever it takes to get into and stay in one of the 15 coveted parliamentary seats that come with a handsome salary and a gorgeous benefit package, the insanity will continue.
I speak from experience, having run on the DP slate in 2014 and as such, I feel I can comment with authority about the type of people described above. For instance: MP Van Hugh Cornelius de Weever.
This politician hijacked the second DP parliamentary seat earned through party votes, including my 129 and started the new 2014/2018 cycle of "I-am-going-to-throw-down-Government-if-I-do-not-get-what-I-want-notwithstanding-the-fact-that-I-am-not-popular-enough-to-get-elected-on-my-own."
To me it is obvious that our system of government, our very democracy is rapidly becoming the subject of ridicule within the Kingdom, the region and the world. But forget what the rest of the world thinks of us. What do we think of ourselves? Why is it that, up to now, we the people accept that a small group of politicians only pay lip-service to the problems of our electoral system, but do nothing to give up their lucrative payday as Members of Parliament and Ministers of Government. I challenge any one to show me one single concrete action that has been taken to stop the insanity where a single politician is elevated to Parliament on the coat-tails of a party leader, or combined party votes, to then promptly bolt (jump) across the aisle with "his/her" seat.
Regardless now of how this latest session of political musical chairs plays out, the result will likely be that the usual suspects return in some form or the other. So why have new elections? Just so that the same bunch of politicians will be able to make even more promises, while pledging their loyalty to party and party leader as a convenient way to hop on to that particular party train to the promised land of a lucrative parliamentary seat? Or is it to have Christmas come early for those that collect money and favors in return for their vote?
I think it is time to face facts St. Maarten. Our system is broken. Reality is, that we vote for people, not for parties. And only a limited few candidates get the majority of all votes. Their political coat tails are such that other (obscure, little known, or unpopular) political candidates are swept into office. Once in the seat, having taken the oath of office, a Member of Parliament, is given a huge amount of authority and power, irrespective of how much public support they personally had. So, where is the democracy in this? Why is it that politicians running on a party slate do not actually have to share that party's principles, values and vision? The ease with which members of parties, once elected to office, can switch loyalty is proof that there is no party loyalty or shared party principles or beliefs! It is pretty sad that we have (and keep) a system in which a candidate, who is unable to earn the required preferential votes from the electorate, can hijack an entire government. Such a candidate must not be able to trade his/her seat.
If a candidate becomes an MP on the popularity of the party, and down the line they cannot, for whatever reason, remain loyal to that party, they should have two options: resign and vacate the seat, making it again available to the party, or alternatively, stay with the party, vote their conscience and let the chips fall where they may (or as they say in USA Politics: Put on your big-boys' pants). A Member of Parliament takes an oath of office to represent all of the people and not to be obliged to any individual or entity. Not towing the party line is allowed, but it takes guts, principles and values. If a politician is sincere in working in the best interest of the people and also wants to stay true to principles of integrity, then he/she should be able to defend his/her view and stand up to his/her party. Trading, or otherwise negotiating deals with a seat in Parliament, for personal gain, is not acceptable. It simply has to stop. Let us eliminate the not-empowered jumper.
This means our electoral laws have to change and it will not happen without public pressure. The next government must make this change a priority.
For now, just as in 2013, 8 is more than 7 and as long as there is a majority in parliament (unfortunately, no matter the characters), ministers (in this case, a majority of whom did not run for office) should not be able to cause the dissolution of a parliament that just gave them (the ministers) a vote of no confidence (fired them).
Michael J. Ferrier


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Endometrial serous carcinoma (ESC) is the most aggressive subtype of endometrial cancer. Its aggressive behavior and poor clinical outcome may be partially attributed to lack of early diagnostic markers and unclear patho-genesis. The transcription factor Erythroid–E2-related factor 2 (Nrf2) is a recently identified protein marker, which plays a role in carcinogenesis as well as responsible for poor prognosis of many human cancers. The aim of this study is to determine the Nrf2 expression in benign endometrium (n=28), endometrial cancers (n=122) as well as their precursor lesions (n=81) trying to see whether Nrf2 has any diagnostic usage and is potentially involved in endometrial carcinogenesis. The level of Nrf2 was evaluated by immunohistochemical (IHC) and verified by using Western blots. Among the malignant cases, Nrf2 was positive in 28 (68%) of 50 ESCs, which was significantly more than in 3 (6%) of 50 endometrioid carcinomas (p < 0.001) and 2 (13%) of 15 clear cell carcinomas (p = 0.001) and other histologic types of endometrial cancers. Among endometrial precursor lesions, both serous endometrial glandular dysplasia (EmGD, 40%) and serous endometrial intraepithelial carcinoma (EIC, 44%) showed a significantly higher Nrf2 expression than that in atypical endometrial hyperplasia or endometrial intraepithelial neoplasia (0%), clear cell EmGD (10%), and clear cell EIC (25%), respectively. We conclude that Nrf2 overexpression is closely associated with endometrial neoplasms with serous differentiation. Alteration of Nrf2 expression may represent one of the early molecular events in ESC carcinogenesis and overexpression of Nrf2 may used as a diagnostic marker in surgical pathology.
Endometrial cancer, the most common gynecologic malignancy [1, 2], has been divided into two major categories: type I and type II [3, 4]. Endometrial endometrioid adenocarcinoma (EEC), the prototype of the Type I carcinoma has a fairly good prognosis, while endometrial serous carcinoma (ESC) or uterine papillary serous carcinoma, a prototype of Type II, bears a significantly worse prognosis. The dismal outcome of ESC was mainly attributed to lack of diagnostic markers as well as inadequately defined carcinogenesis.
Erythroid–E2-related factor 2 (Nrf2), is a significant nuclear transcription factor maintaining intracellular redox homeostasis through regulating the transcription of a series of target genes [5-7]. The main biologic function of Nrf2 is antioxidant insult [8-10]. It is known that activation of Nrf2 confers protection against many chronic diseases including cardiovascular diseases, lung inflammation, and diabetic nephropathy [5, 6, 11-18]. Mechanistic studies of Nrf2 showed that it is generally maintained in a low basal level and constantly regulated at the protein level by a negative regulator named Keap1 through ubiquitination and proteasomal machinery [19]. Chemopreventive compounds are able to stabilize Nrf2 through inhibition of Nrf2 degradation, thus enhancing the protein level of Nrf2 and activating the Nrf2-dependant antioxidant response [20, 21]. However, the dark side of Nrf2 has recently been revealed [22, 23]. Mutations or change of Nrf2 expression levels have been identified in many cancers [24-27] including endometrial cancers [28]. Deregulation of Nrf2 by its regulatory genes results in overexpression of its downstream genes that intensify the Nrf2-dependent protective mechanism and provide cancer cells with a growth advantage [24-27] and chemoresistance to many chemotherapeutic drugs in common human cancers [23, 29-31]. Addionally, Nrf2 may play a role in initiation of cancer development. It was demonstrated that increased Nrf2 and GSTP1 were closely associated with the early hepatocarcinogenesis [32] and arsenic induced skin cancer [33]. Based on above understanding, we suspected that, among the perplexing role in many human cancers, constitutive Nrf2 activation or overexpression may be involved in the process of endometrial serous carcinogenesis.
In this study, we investigated the level of Nrf2 protein expression in a large number of pathological endometrial samples including benign endometrial, precancerous lesions, and different type of human endometrial cancers to determine whether Nrf2 is differentially expressed in the endometrial tissues and whether expression differences among the different types of endometrial samples including those precancers could be exploited to facilitate our understanding of type II endometrial carcinogenesis and to serve as an additional diagnostic marker.
All endometrial samples were retrospectively retrieved from the Department of Pathology at the University of Arizona from 1996 to 2009 under the approval of the Institutional Review Board for human tissue usage. Among all the studied cases, no malignancies with a history of prior radiation or chemotherapy were included; while benign cases with personal cancer history or transplantation therapy were excluded. Case review was accomplished under the light microscopy using corresponding hematoxylin and eosin-stained slides to reconfirm the endometrial histogical types (Olympus BX41). Carcinomas with more than 10% mixed histological component were ruled out. A total of 231 specimens were studied which included benign endo-metrium (n=28), atypical endometrial hyperpla-sia or endometrial intraepithelial neoplasia (n=18), serous endometrial glandular dysplasia (EmGD) (n=20), serous endometrial intraepithelial carcinoma (EIC) (n=25), clear cell EmGD (n=10), clear cell EIC (n=8), endometrioid carcinoma (n=50), serous carcinoma (n=41), clear cell carcinoma (n=15), mucinous carcinoma (n=8), and other malignancies (n=8). Cancers grouped in the other category included those undifferentiated carcinoma (n=3), carcinosarcoma (n=3), squamous cell carcinoma (n=2).
Cases matched both atypical hyperplasia or EIN were included into the hyperplasia/EIN category [34-37]. EmGD was diagnosed as defined by Zheng et al [38, 39] and the diagnostic criteria for serous EIC were based on Ambros et al [40]. Clear cell EmGD and EIC were diagnosed according to previously described morphologic criteria [41]. All malignant cases were diagnosed, graded and staged using criteria of the International Federation of Gynecology Oncology (FIGO)[42, 43].
Tissue sections were all derived from hysterectomy specimens. All uteri obtained were processed for 10% formalin fixation and paraffin embedding. Paraffin sections were cut at 5-um thickness and placed on Super Plus slides (Fisher Scientific, Pittsburgh, PA). For every case, one section was stained with H&E and examined microscopically to confirm the pathologic diagnosis.
A rabbit monoclonal antibody (EP1808Y) specifically reacted with human Nrf2 (IgG2) was purchased from Abcam, Inc. (Cambridge, MA). The antibody and IHC has been successfully used in previous studies [28]. Sections of ESC (known to express Nrf2) served as positive controls [28]. The staining reaction was evaluated only in epithelial cells. For those cases containing multiple lesions (such as EmGD or EIC in cases of ESC), each of the foci was separately evaluated. All IHC slides were reviewed independently by two investigators (N.C. and W.Z.). The percentage and intensity were arbitrarily divided into 5 and 4 tiers, respectively (see Table 1). For the purpose of better description and statistical analysis, we created positive score index which represented a sum of total Nrf2 expression in each category. Majority Nrf2 expression was observed in cytoplasm, while only small percentage of cases showed nuclear staining. Therefore, no data were analyzed for nuclear staining.
Twenty frozen endometrial tissues and endometrial cancer cell lines (Ishkawa and SPEC-2) were homogenized and the samples were loaded in SDS gels and subjected to im-munoblot analysis as previously reported [44]. Intensity of the signal was measured by densi-tometry software (NIH Image 1.61). Relative expression of Nrf2 was normalized by the amount of the β-actin in every lane (calculated as the ratio of Nrf2 to β-actin).
Comparison of IHC Nrf2 expression in different status of the endometrium was assessed by Chi-squares and Fisher's exact test when an expected cell value was 5 or less. Nrf2 immunoreactivity index between type I and type II endometrial cancers including their putative precursor lesions were calculated by paired-comparisons t test by PROC MEANS in the SAS system.
Most of the benign endometria showed a non-detective level of Nrf2 expression. Only a few showed weak positive staining of Nrf2 in a small percentage of the cells. Of the 28 tested benign cases, 1 (4%) atrophic, 2 (7%) proliferative, and 1 (4%) secretory endometria showed weak Nrf2 staining in less than 25% of the cells. The Nrf2 staining index overall was 30 or less for the staining extents and 20 or less for the intensity in the benign endometrial glandular cells. Detailed data are summarized in Table 1.
A total of 81 precursor lesions studied, the extent of Nrf2 (score index) was the highest in serous EIC (204), followed by serous EmGD (190), clear cell EIC (114), clear cell EmGD (100), and AEH/EIN (33). The score index for the staining intensity among the above lesions showed a similar order with the highest in serous EIC (164), followed by serous EmGD (125), clear cell EIC (100), clear cell EmGD (60), and AEH/EIN (50). Detailed data are summarized in Table 1. Representative pictures displaying Nrf2 expression in endometrial precursor lesions are presented in Figures 1 and and22.
Among all 122 studied endometrial cancers, Nrf2 expression was the highest in cases of ESC with the extent and intensity score index of 279 and 189, respectively. This was followed by other carcinoma category (113 and 125), clear cell carcinoma (96 and 81), endometrioid carcinoma (62 and 44), and mucinous carcinoma (13 and 13).
In cases of ESC, 37 (90%) of 41 had Nrf2 expression with 37% showing staining in more than 80% of the tumor cells and at least moderate intensity in more than 80% of the cases. This was dramatically different from endometrioid carcinomas, which only had 1 (2%) of 50 with more than 80% cells and 5 (10%) cases with moderate intensity of Nrf2 expression. Overall there were 17 (44%) of 50 endometrioid carcinomas showed various levels of Nrf2 expression in cytoplasm. Based on FIGO grade, the distribution of FIGO grades in the 17 endometrioid carcinomas with Nrf2 staining was as follows: grade 3 (n=7), grade 2 (n=9), and grade 1 (n=1). The mucinous carcinoma showing Nrf2 staining was a FIGO grade 2 tumor. Since there were not enough cases of type I endometrial cancer that showed any Nrf2 expression, the relationship between Nrf2 staining and tumor grade and the depth of myometrial invasion were notevaluable.
The level of Nrf2 expression was intermediate in other carcinoma category. This was probably due to the mixture of cancers including undifferentiated carcinomas and squamous cancers in this category. The level of Nrf2 expression in clear cell carcinomas was similar to those cancers in the other category, while the lowest expression was seen in mucinous carcinomas.
Nrf2 immunoreactivity was negative in stromal cells, myometrium and vascular endothelia among all cases studied. The summarized data are presented in Table 1. Representative images displaying Nrf2 expression patterns in endometrial cancers are presented in Figure 3.
Nrf2 expression was mainly in cytoplasm and the level of expression was heterogeneous. If positivity for Nrf2 is defined as ≥50% staining, irrespective of intensity of staining, the results can be summarized as follows: Of all endometrial cancer precursors, Nrf2 staining was positive in none of AEH or EIN cases, 40% serous EmGDs, 44% serous EICs, 20% clear cell EmGDs, and 25% clear cell EICs. Among all endometrial cancers, we observed that Nrf2 was positive in 6% EECs, 68% ESCs, 14% CCCs, none of mucinous carcinomas, and 25% of other endometrial cancers. The data are summarized in Figures 4 and and55 and corresponding statistical comparison results are listed in Table 2
Overall, ESCs including their precursor lesions showed a significant different staining pattern for Nrf2 compared with type I cancers and their precursor lesions (p < 0.001). Both ESC and CCC are classified into type II cancers, however, ESC showed a significantly higher frequency of Nrf2 expression (68%) than CCC (13%) (p = 0.001). Although CCCs showed a higher Nrf2 friequency (13%) than EECs (6%), the difference was not statistically different (p = 0.325). When comparison was carried out inside those serous subgroups, Nrf2 expression was significantly higher in ESCs than that in lesions of serous EmGD (p = 0.035) and serous EIC (p = 0.052). However, there were no significant differences for serous EIC when compared with serous EmGD. For all clear cell lesions, no statistical differences were found among EmGD, EIC and CCC. Among all EIC lesions, the difference of Nrf2 expression approached a statistical significance between serous and clear cell EICs (p = 0.05). Within the category of EmGD, there were no significant differences of Nrf2 expression between serous EmGD and clear cell EmGDs (p = 0.119). Compared with both serous and clear cell EIC, AEH or EIN showed less Nrf2 positive cases (p < 0.001) than the former but no difference than the later. The similar findings were observed in the corresponding type II precancerous lesions. The above data are summarized in Table 3.
We also used western blots to measure the reactivity of Nrf2 antibody with Nrf2 protein produced by endometrial cancer cell lines and neoplastic endometrial tissues. Nrf2 antibodies reacted with a protein at about 110 kD, the expected molecular weight for Nrf2 (Figure 6). Nrf2 was highly expressed in SPEC-2 cells, an endometrial carcinoma cell line derived from tumor tissue of ESC. In contrast, marginal expression of Nrf2 was detected in Ishikawa cells, which was derived from a well differentiated EEC. Among the endometrial tissues tested, the highest level of Nrf2 was seen in cases of ESC and serous EIC. The level of Nrf2 expression in a case of EmGD was comparable to a case of endometrioid carcinoma. No Nrf2 was detected in cases of mucinous carcinoma or AEH/EIN or benign proliferative endometrium. The cases with highly expressed Nrf2 detected by western blot also showed high level of expression in IHC slides, while the lower or none expression cases were negative on IHC slides. Therefore, the results of IHC and western blot were correlated to each other.
In the last 2 decades, there have been great progress in the study of carcinogenesis of type I endometrial cancer [45]. However, studies on type II carcinogenesis have been remarkably limited until recently. Type II endometrial cancer represents only about 15% of the endometrial cancers but accounts for approximately 80% of endometrial cancer-related deaths [46]. In contrast, type I cancers constitute up to 85% of all endometrial cancers which are typically with a good prognosis. Therefore, the development of molecular markers specific for the different histologic types would provide useful adjuncts to the morphologic assessment of endometrial lesions and thus facilitate patient care. Meanwhile, it is clinically important if the molecular markers actually play a role in carcinogenesis so that an effective therapeutic intervention may be administered.
In this report, we examined the expression of Nrf2 in a large number of endometrial tissue samples. We found that Nrf2 is an excellent cytoplasmic marker by immunohistochemistry to differentiate ESC from other endometrial cancers. Nrf2 was expressed in a significantly higher proportion of ESC (68%), as compared with endometrioid carcinomas (6%) (p < 0.001), clear cell carcinoma (13%) (p = 0.001), and other endometrial cancers (Tables 1 and and2).2). Mucinous carcinoma showed negative staining in 7 of the 8 cases tested. Non-neoplastic endometrial tissues were mostly negative. Therefore, assimilation of entire data indicates that Nrf2 expression pattern appears to be completely different between ESC and other endometrial cancers. Nrf2 seems to be a highly sensitive and specific cytoplasmic marker for the serous type of endometrial cancers. Positive staining, particularly in more than 50% of the neoplastic cells with at least moderate staining intensity, may lead us toward the diagnosis of an endometrial serous neoplasm, which has a serious impact in clinic [47, 48].
Furthermore, Nrf2 protein expression was dramatically different among the endometrial precursor lesions. EmGD including both serous and clear cell types are recognized precancers of ESC and CCC, respectively [38, 39, 49, 50]. Serous EIC, although develops earlier than ESC, is considered an early form of ESC due to its high association of extra uterine disease [47, 51, 52]. AEH and/or EIN are well recognized type I pre-cancer [50]. Nrf2 was negative in such lesions (Table 2), whereas it was positive in a substantial number of precursor lesions of type II cancer, which illustrated an interesting contrast. The expression rates of Nrf2 were dramatically increased in both serous EmGD (40%) and EIC (44%) as compared with lesions of AEH/EIN (0%) or corresponding clear cell precursors (10% and 25%, respectively) (Table 2). In our opinion, the congruence in the expression rates between serous EmGD and serous EIC suggests that endometrial neoplasia with serous differentiation is not only different from those with endometrioid as previously known [45] but also different from those with clear cell differentiation. Moreover, the high level of Nrf2 expression in serous EmGD is a solid line of evidence linking this precancer to the full-blown ESC.
More evidence has indicated a positive role of Nrf2 in carcinogenesis and chemoresistance. The first evidence came from the finding that Nrf2 was elevated during hepatocarcinogenesis [32]. Its elevation was then found in many cancers including lung, ovary, and breast when the Nrf2 negative regulator Keap1 lost function [23-27, 30, 31]. Using genetic manipulation, Zhang's group and others have demonstrated a strong positive correlation between Nrf2 levels and resistance to chemotherapeutic drugs such as cisplatin in both endometrial and ovarian cancer cells [23, 31]. Furthermore, we have recently shown that reduced levels of Nrf2 (either directly or via manipulation of its negative regulator) significantly sensitized SPEC-2 cells and its xenografts to chemotherapeutic drugs [28]. Collectively, these findings may explain why Nrf2 is associated with tumor progression and the aggressiveness of ESC. Further studies are required to investigate how the level of Nrf2 is regulated in ESC and its precancers.
It is interesting to note that Nrf2 expression in CCC and its precursors was closer to that in EEC, rather than that in ESC. There is, thus far, no molecular study on endometrial cancer that included a sufficient number of clear cell carcinoma has been published. In various studies, a small number of CCCs were analyzed, mostly together with ESC. Thus, it has been speculated that CCC is similar to ESC. However, evidence supporting that they have different molecular pathogenesis pathways does exist. Compared to ESC, alterations of p53, PTEN, K-Ras, and EGFR were significantly different in CCC [53, 54]. Therefore, it is not clear if pathogenesis of CCC is similar to ESC. Significantly different Nrf2 expression between CCC and ESC and their precursors is supportive of a different pathogenetic mechanism in these type II endometrial cancers.
In summary, our results in this study indicate that expression of Nrf2 is closely associated with endometrial serous cancer, while it seems not related to type I endometrial cancer. Importantly, strong and diffuse Nrf2 cytoplasmic expression is highly sensitive for ESC including its early and pre-cancers. As a result, Nrf2 may serve as a useful diagnostic marker in the assessment of endometrial cancers and their precursor lesions, particularly when the amount of available tissue material is limited and morphology is ambiguous. Alteration of Nrf2 expression may represent one of the early molecular events in the neoplastic transformation of endometrial serous cancers. Furthermore, overexpression of Nrf2 may be partially responsible to the aggressive biological behavior and dismal clinical outcome of ESC due to its known effect of increased resistance to chemotherapeutic drugs. The findings may also provide an opportunity for therapeutic intervention against chemoresistancevia applications of either Nrf2 inhibitors or gene knockdown approaches for ESC.
The project was supported in part by Better Than Ever Fund, P30 CA23074 from Arizona Cancer Center and Department of Pathology, University of Arizona Startup fund to WZ. Dr. Ning Chen is a Ph.D. candidate of Shandong University, Jinan, China. Partial funding of her training was supported by Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Click to visit our new site, www.prolifepulsela.com, to apply for PLI!
(Application will be available online and to download on April 1, 2016).
The PULSE Leadership Institute will be held from June 19-24, 2016. Applications will be accepted online until June 12, 2016 or until event is filled. After that, please call us at 1-866-463-5433.


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Even people who live in modern, first world countries are aware of the fact that providing clean and drinkable water is a huge problem in many parts of the world. With pollution, natural catastrophes and lack of care for the Earth, this is slowly becoming a problem even in developed societies.
The Katadyn Pocket Water Filter can resolve a number of drinkable water supply issues, and one of its advantages is definitely that it is applicable to outdoor activities such as camping, trekking, hiking and other activities that require spending time in nature where you are far from clear water sources, as well as in situations when people need to survive in nature due to the unpredictable circumstances.
The Katadyn Pocket Filter works as a water filtration system, and it is able to filter particles up to 0.2 nanometers. It is intended to remove all parasites, viruses, bacteria and fungi from water, without using chemicals, boiling, UV power – or anything other than their filtration system.
Katadyn Water Filter
Knowing that the smallest known virus in the world is 25 nanometers and the Katadyn is able to filter particles up to 0.2 microns, we can say that the bar is set high for the water filtration system and technology.
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The bottle holds 750 ml of water at a time, and there are two models: LifeSaver 4000 and LifeSaver 6000. The difference between the two is that the first one gives you 4000 liters of clan water before the filter needs to be replaced, while the second one gives you as much as 6000 liters. This makes the LifeSaver Bottle ideal for long expeditions and for unpredictable situations that require survival in nature.
LifeSaver Bottle is very simple to use. First, you need to unscrew the base of the bottle and dip it into the water source, such as stream, river, lake or even a puddle. After this, replace the cap and pump the piston on the bottle several times in order for the water to pass through the filter. After doing this, you will have clean water which is safe to be consumed. When the filter is near the end of its usability, there will be more pumps needed to filter the water. When the water stops flowing through the system, it is time for changing the filter. This is a mechanism created on purpose, in order to prevent the users from drinking water that has not been filtrated.
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This Saturday, October, 15th from 11am - 5pm, Alternate Reality Comics will be hosting an artist / cosplay event benefiting The Boys & Girls Club of Las Vegas! Visiting artists from Arizona include Andy Bohn (creator, writer, artist of The Elvatron Chronicles) and Michael Stewart (who has penciled Magdalena for Top Cow), who will be joining local artist, Brice Gielgens, in sketching as well as having exclusive prints for sale! For eye candy in fabulous copsplay costumes, local favorite and Zenescope Girl of the Year, Brieanna Brock, will be joined by Agelica Virgie and Anna Von Winter!
There'll be a raffle for original art and other fabulous prizes (including gift certificates) and a HUGE .25 back issue sale, with the money raised from the raffle (raffle tickets only $1.00 each) and the back issue sale being donated to The Boys and Girls Club of Las Vegas to raise money for their art program.
We'll also be providing free snacks and beverages, so we hope to see a lot of our friends (and your friends and neighbors!) this Saturday, October, 15th from 11am-5pm for a fun time with some great up and coming artists and cosplay performers, raffles, and a back issue sale benefiting a great local organization, The Boys and Girls Club of Las Vegas!
And if you want to kick off the fun that Saturday will be, tonight (Thursday) over at Buffalo Wild Wings (190 West Craig Road, close to Craig and Commerce) from 8:30pm until whenever, there will be a drink and draw with the whole gang! You can come to drink, draw, and or just socialize!
Thursday, October 13, 2011
Saturday Boys & Girls Club benefit / artist event!
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Happy New Comics Wednesday 1/17/18 - James Robinson's Trinity, an EXCELLENT issue of Kill Or Be Killed, a great new odd tiitle, Ice Cream Man!, Batman, Superman edition!
And a great Superman tear-jerker!
Tomorrow, Saturday, November 5th, from 10-4pm, the fourth annual Vegas Valley Comic Book Festival will be happening and it won't be as ...
I'm thankful for many things, not just today, but every day. I'm thankful for Kate, my wife, my many friends outside of my store a...
Happy New Comics Wednesday 2/22/17 - Jamses Robinson's last issue of Scarlet Witch!, Justice League of America #1, new Rucka Image title, Old Guard, Wonder Woman, Fix, Thanos, IVX edition!BIG SALE on Marvel Omnibuses!! Bonus Shade photo, he's five months old!


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Even an "avid Facebook fan" is now angry with the company's
silence on Beacon. Nick O'Neill on allfacebook:
After talking with some large agency representatives tonight, I'm realizing that Facebook has been damaging their momentum with brands over the past week. One person that I spoke with informed me that a number of their larger clients were extremely hesitant about any advertising or marketing campaign that involves Facebook due to the negative press that has been going around.
O'Neill recommends a public statement. So does
Robert Scoble. So
do we. And Josh Quittner over at Fortune has even written the
company's obituary.
(It's true, though: We're going to get bored of this issue pretty
soon--as, we imagine, will everyone else).
See Also:
How Mark Zuckerberg Can Save His Sinking Reputation
Two More Advertisers Say No to Facebook's Beacon
NYT: Zuckerberg Misled Us; Coke: Ditto


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The sun at odds with Pluto on your birthday means you will face many challenges, but never doubt you have what it takes to fight and win. As an Aries, you're at your best when your back is to the wall.
ARIES (March 21 – April 20):
Take what you desire rather than wait for someone to offer it to you. Whatever your number one ambition in life happens to be, that is what you should now be aiming for. Your dreams will all come true.
TAURUS (April 21 – May 21):
Usually you get your way through sheer force of personality, but cosmic activity in the most sensitive area of your chart makes that more difficult now. If you want something you'll have to offer something in return.
GEMINI (May 22 – June 21):
Requests for help of a financial nature will come your way, but if you are smart you will turn them all down. The best way to help others is to show them how to help themselves. Most won't want to know.
CANCER (June 22 – July 23):
Someone in a position of authority is about to offer you the chance to move several rungs up the ladder of success. Before you proceed ask yourself a serious question: Do you really want this level of responsibility?
LEO (July 24 – Aug. 23):
Your confidence may be soaring now, but don't go to extremes. At best you will make a fool of yourself; at worst others will expect you to be like that all the time. Try not to forget it's only an act. Isn't it?
VIRGO (Aug. 24 – Sept. 23):
You may feel irrationally jealous today, which is not like you at all. The fact is, your nerves are still on edge from the effects of the recent full moon, so stay calm and try to take nothing too seriously.
LIBRA (Sept. 24 – Oct. 23):
The best way to avoid confrontation is to remove yourself from areas where it is most likely to take place. Everything will be fine if everyone respects your space – and, of course, you must respect theirs.
SCORPIO (Oct. 24 – Nov. 22):
You may have a lot of practical issues on your plate at the moment, but don't neglect your feelings – or the feelings of those you love. Make time for others today – and even more time for yourself.
SAGITTARIUS (Nov. 23 – Dec. 21):
The sun in Aries is bringing all sorts of opportunities your way – all you have to do is reach out and grab them. But don't be greedy: there is plenty of good stuff to go around. Strive for quality work, not quantity.
CAPRICORN (Dec. 22 – Jan. 20):
You may have to hide your true feelings if you want to avoid a scene. If you fall out with someone today they will be in a huff for weeks, so bite your lip and focus on things you can agree on.
AQUARIUS (Jan. 21 – Feb. 19):
Seek out people who are fun, people who make you laugh when you are feeling down. And don't think of it as wasting time, because it's nothing of the sort. Happiness is worth making an effort for.
PISCES (Feb. 20 – Mar. 20):
You may be tempted to rush around today and finish all those half-completed jobs you think are so important. Don't bother. If they really were that important you would have done them all by now.
For your extended forecast, call 1-900-783-8333, or 1-877-976-1414 for credit-card access. Calls cost $1.49 per minute. www.sallybrompton.com
Visit Sally at www.sallybrompton.com
For your extended forecast, call 1-900-783-8333, or 1-877-976-1414 for credit-card access. Calls cost $1.49 per minute.


text:
"Tourism that involves travelling to relatively undisturbed natural areas with the specified objectives of studying, admiring and enjoying the sceneries and its wild plant and animals as well as in existing cultural aspects"-Defined by WTO.
Key elements of Eco-Tourism:
- Existence of National Park/ Sanctuary/ Nature of prime attraction.
- The area should be ecologically, socially, culturally and economically sustainable.
- Tourism sector should have participation of local stakeholders.
- Ecologically sustainable infrastructure should be developed.