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Certificate of Excellence award 2012, 2013 and 2014 Read the Reviews
It can all be a little overwhelming, the city may not be huge but the culture, activities, events, eateries etc. is vast. So we have taken it upon ourselves to amalgamate our local 12 years experience in the city via our blog. Whether you are planning on coming over for the festivals, want to find out vegan eats or general insider information, we will keep you in the loop.
CaixaForum presents a wonderful exhibition that encourages one to evaluate the uncertainty that many undergo in life in general. Whether it is inequality, pressure of conformity amongst other things, they are things that many can identify with. The exhibition is centered around a space and rather spread out, perhaps representing the concept of freedom and loos at the pivotal role art can play during this state of affairs.
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If you like photography you will definitely appreciate this fine selection of winning photographs from the last 20 editions of LUX prizes (acclaimed reference for professional photography). Located and jointly organised by Palau Robert and the Association of Professional Photographers of Spain – the project went ahead with the view to capture strength and development during social and economical change.
Those that live in the city know just how much of an exciting technology hub Barcelona is. Not only is the city home to sun, sea and sand, it is also a leading place when it comes to technological innovation and start-ups. It is then no wonder that the Mobile World Congress, the world's largest exhibition hosts it's feria here, from the 25th to the 28th February.
Next month sees the return of one of the world's largest tradeshows, Cosmobelleza, due to take place on the 2,3 and 4 February. This 2013 edition is expected to be brimming with beauty, hair and other products, seminars, workshops, giveaways and more.
World Press Photo is one of the most established and prestigious photojournalism competitions in the world. Think – 156 award winning photos, eight cities of forty countries and I think you can understand the depth that much more. The exhibition is on in Barcelona at the CCCB until 6th January and is a sure hit in the city, last year saw 35,159 visitors attend.
El Parallel is the underground neighborhood that was once the go to place for sheer entertainment and marvels. Xavier Alberti and Eduard Molner attempt to rescue the cultural locality that sent tremors in what was the polite society during 1894-1939 with a curation of Parallel's theatrical, political and sexual world during the exhibition, aptly named ´El Paral•lel, 1894-1939, Barcelona and the Spectacle of Modernity´.
Now it is not hard to notice that there has been somewhat of an influx in bakeries offering more than just a magdalena. There has equally been a rise in baking at home with more people taking an interest and taking classes, offered by those such as Diary of a Cake Maker.
There is nothing like a visit to the museum to make you realize just how much talent one individual encompassed, in what was somewhat limited times. This is what can be seen from the multifaceted and talented Italian artist Giambattista Piranesi – who was an architect, etcher, and designer. Obra Social La Caixa Foundation presents The Arts of Piranesi an exhibition that brings extensive works such as engravings and sketchings from the artist.
Mapping Barcelona Public Art (MBPA) kickstarts the autumn with their first exhibit Las Calles Hablan (The streets speak). Created by Katrine Knauer, this exhibition is a collection of images of street art throughout Barcelona city to help redefine the importance of graffiti. Many tend to have an immediate reaction when it comes to street art, they either love it, hate it or perhaps simply don't understand it.
La Virreina´s current exhibition From the Factory to the World. Photography and the Warhol Community, examines the pivotal role played by photography in creating the Factory's elaborate bohemian culture. The Factory was Andy Warhol's New York studio, which, was renowned for it's huge parties and celeb musings. Here you can see printed works, polaroids and videos of this hectic lifestyle and artists and celebrities such as Edie Sedgwick, Cecil Beaton, Christopher Makos and Stephen Shore are just some of those that are included.
DestinationBCN Apartment Suites in Barcelona: firstname.lastname@example.com / www.destinationbcn.com / © 2012 DestinationBCN Apartment Suites in Barcelona


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Troy State University employment opportunities
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Information about Troy State University employment opportunities, and registering for elective seminars. Which college degrees give you the best chances of finding employment after graduation? There are a variety of accredited business programs that may appeal to you. Advertising, accounting, human resources, and business management are just a few options. Concentrating on Troy State University employment opportunities, for example, you may gain an advantage in corporate recruiting being done on-campus. Check with the workforce development department for course registration deadlines, and career training program requirements. Please use the form above to request admissions info for Troy State University.
As the economy improves, many firms are beginning to hire. Companies are in need of candidates that can fill a particular job position, so set up an introductory meeting to ask questions about the firm's history, and current business opportunities. Review your prior work experiences, internships, volunteer experience, interests and hobbies. For each item on your list, identify the skills and knowledge you developed, because many skills are transferable to the job you're applying for.
Before a first interview, analyze the open position that you are applying for. Review the job description carefully, and highlight both the employment qualifications and job responsibilities. At the same time, learn as much as you can about the company's mission, corporate services, product lists, and main competitors. Start your research on the company's website, then do an article search on Google, and attend career information sessions and job fairs that are held on campus. Beyond major requirements within the workforce development department, you may consider South Seattle Community College changing a course as a complementary elective to your primary course of study.
Financial Analyst, Federal
Anglin Consulting Group
Serves as a Financial Analyst with a group of analysts who are working in concert to systematically integrate business processes, especially pertaining to ..
3 days ago Front Office Operations Analyst Manager
Benchmark Physical Therapy
The Front Office Operations Analyst Manager ensures that there is effective coordination between the front office and other company organizational areas, such..
3 days ago Graduate Admissions Coordinator
Santa Clara University
Implement communications plan for prospective and admitted students (e.g., run email campaigns, send decision letters, send Student ID's, reminders to..
23 hours ago Site Office Coordinator
Kern Community College District
Business letter writing and report preparation. Letter of interest (Cover Letter). Compile data and maintain complex records and prepare reports.
1 day ago Payroll Technician/Accounting Technician...
Metro Finance and Regulatory Services is looking for a person who enjoys working in a collaborative environment to assist both the Payroll and Accounts Payable..
7 days ago Budget & Financial Management Analyst
Pinellas County, FL
Serves as a leader on assigned projects of research and analysis of financial data from complex data management systems..
1 day ago

subset: commoncrawl


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Planning to head to the Linc this fall? Then you'd better leave those handbags, diaper bags and seat cushions at home. The NFL announced new security measures purported to increase efficiency and security at stadiums around the country that require many football fans to leave much of their usual game day gear at home.
Fans will only be allowed to bring in small clear plastic, vinyl or PVC bags that do not exceed 12″ x 6″ x 12″. Or, you can make your stadium visit much like the pleasantness of going through airport security by bringing in a one-gallon clear plastic freezer bag or a small "clutch bag," about the size of a hand (with or without a strap).
Keep in mind that, once you enter the facility, there will be nowhere to conveniently place these items other than to lug that Ziploc bag around with you. Sounds entirely pleasant and suitable for most game day experiences, right (not at all)?
Prohibited items will now include: purses larger than a clutch bag (i.e. pretty much all of them), coolers, briefcases, backpacks, fanny packs, cinch bags, luggage of any kind, seat cushions, computer bags and camera bags or any bag larger than the permissible size.
Blankets will still be allowed for fans to bring in to stadiums.
In sum, bring as little as you can with you. Which will be a far easier task for some fans than others.
As the new policy was handed down by the league, all NFL stadiums must enact the new provisions. This means that the clear bag rule will be in effect for Philadelphia Eagles' five open practices at Lincoln Financial Field this summer (7/28, 8/5, 8/11, 8/17, 8/26), so be sure to take heed of the changes if you're planning to head to training camp.
It will be interesting to see if the policy remains as is or if fan feedback will cause for some modifications to the new security rules.
Follow Philly Sports Muse on Twitter at @sports_muse and on Facebook.


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MINKS offer up a strong measure of pop, subtle sass, movement, and atmosphere on their latest album, Tides End, released back in August. The record is easily one of my most played of the last couple months and I could tell you more, but what do words mean when no one listens anymore. All that aside, get to business with some music below.
"Everything's Fine"
"Painted Indian"


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Will this new expansion include new music? I was extremely disappointed that the last expansion did not include new themes for Rise of Isengard. Please Turbine, commission new music from Chance Thomas.
Will this new expansion include new music? I was extremely disappointed that the last expansion did not include new themes for Rise of Isengard. Please Turbine, commission new music from Chance Thomas.
There were plenty of new music themes in Isengard. Dunno how you managed to miss them.
No there weren't. All of it was reused music from other areas. There was nothing on the order of the themes in Rivendell, The Shire, Lothlorien or Moria.
Galtrev reused music from Bree. The area right outside Galtrev, an enemy logging camp, reused music from Winterhome (of all places). Many places had reused music from the skirmishes.
They definitely skipped the music in the budget in ROI. I hope it doesn't happen in next expansion.
Galtrev and Tur-Morva had re-used sound, fine. But Trum Dreng had a new theme, Carreglyn had a new theme, Grawenwood had a new there, Nan Curunir had a new theme, Fangorn's Edge instance has a new there and so forth. In general, RoI has been a steady mix of new and old themes and saying there were no new ones is very much incorrect.
I heard new music, too.
And there will be new music in Rohan.
Listen carefully.
Still it'll be great if they hire Chance Thomas or some other composer again. Rohan needs more than just synthesized music pieces.
"Aurë Entuluva!"
Yes, new music would be fabulous!
I vote for Ramin Djawadi, probably best known for his work on Game of Thrones, which has an amazing score in my opinion. I'd like to see what he can bring to the table. I've personally never felt overly compelled by the music of this game. The main theme has a really generic feel to it for me. But I agree either way, I'd like some new music for Rohan that definitely feels Rohirric. I thought it was a bit lazy of Turbine to reuse music, especially the Bree-theme in Galtrev which, honestly doesn't fit in there at all.
I second the motion! New music all around!
[SIZE=3][FONT=Book Antiqua][COLOR=Cyan]"If more of us valued food and cheer and song above hoarded gold, it would be a merrier world."[/COLOR]
~ JRR Tolkien[/FONT][/SIZE]
I hope they can get Jeremy Soule. His work on The Elder Scrolls series is awesome. I think I'm in love with him. <3
'A cage,' she said. 'To stay behind bars, until use and old age accept them, and all chance of doing great deeds is gone beyond recall or desire.'
New Music was in:
- Moria
- Lothlorien
- Mirkwood
- Enedwaith
- Isengart
In all new regions...
I should have thought it was obvious.
For what it's worth, I didn't notice any new tracks. If there were any in the questing areas, I've long forgotten about them. If anywhere, there should have been new tracks in Galtrev, not in the questing areas, considering that's where everybody is spending their time. It makes no sense to have new tracks in areas where people only spend, at most, a few days to a week, and then reuse tracks from Bree and Aughaire for the area people spend the majority of their time.
I agree. Mirkwood had memorable music in each zone, but from Dunland all I can remember is the Tal Mathedras music. I think another couple of new ones cropped up - one I thought was new was taken from skirmishes - but were pretty forgettable. It's not like Evendim, or the Shire, where the music is distinct and evokes emotions from the quests we did there.
'A cage,' she said. 'To stay behind bars, until use and old age accept them, and all chance of doing great deeds is gone beyond recall or desire.'
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All five editions of Schools Wikipedia were compiled by SOS Children. SOS Children's Villages helps more than 2 million people across 133 countries around the world. There are many ways to help with SOS Children.


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Above Rubies Daily Encouragement Blogs
Through the weekly and daily devotionals you can be constantly encouraged in your great role of parenting, the highest career in the nation. You can also stay updated on what's happening with the Above Rubies ministry.
How do people around you describe you as a family? How do the people in your community describe the church you go to?
In the early church Christians were known as the people who "call upon the name of Jesus Christ." Saul, "breathing out threatenings and slaughter" sought to arrest and imprison all those who called upon the name of the Lord.
This should be the lifestyle of every believer and the testimony of every God-fearing family.
Is it your habit to gather your family each day to call upon the name of the Lord? Jeremiah 10:25 is a big challenge to families: "Pour out thy fury upon the heathen that know thee not, and upon the families that call not on thy name." This Scripture says that if we are not families who call upon the name of the Lord, we may as well be heathen families.
There is so much for which we need to call upon the Lord. For our own family. For this nation. The nations of the world. For Israel. For the persecuted church. How can we forget about our fellow brothers and sisters who are being persecuted around the world? We dare not forget them in prayer. Hebrews 13:3 9 (NLT) says: "Remember those in prison, as if you were there yourself. Remember also those being mistreated, as if you felt their pain in your own bodies." Is this how you pray for them each day?
What is another priority in prayer? 1 Timothy 2:1-3 says: "I exhort therefore, that, FIRST, supplications, prayers, intercessions, and giving of thanks, be made for all men: for kings and for ALL THAT ARE IN AUTHORITY: that we may lead a quiet and peaceable life in all godliness and honesty." Therefore, we have a responsibility to pray for our president and those in authority. Do your hold them up in prayer each day as a family?
Recently my husband was speaking to a group of men—good, upstanding, faithful Christian men. And yet when he asked who prayed for President Trump in their home each day, only one man put up his hand.
It's time to take up our responsibility. We are obligated to hold up Trump's hands. Remember the story of Joshua fighting the Amalekites? When Moses held up his hand, Israel prevailed, but when his hand got tired and he let it down, the Amalekites prevailed. Therefore, his brothers, Aaron and Hur stood either side of him and held up his hands and they wasted the Amalekites!
We now have Trump's slogan to make America great again. But this can't happen without prayer. The prayers of God's of families. Because if families are not praying together, churches will not be praying. Everything starts in the home.
Can you imagine what could happen in our nation if every God-fearing family prayed daily for our president and those in authority? We miss so much of God's blessings because we do not pray.
I am challenged by the words of Norman V. Williams: "God didn't make the course and destiny of nations and of individuals dependent on the decisions of Congresses and Parliaments, nor did He lay this power in the hands of rulers and kings; but rather God placed it in the praying family! Therefore, the devil cannot ruin nations of men until he has destroyed the homes of prayer! That's why Satan hates the family altar."
Praying families have the power to turn the tide in this nation. But will we, do it?
Blessings from Nancy Campbell
Calling on the name of the Lord, OT: Genesis 4:26; 1 Kings 18:24; Psalm 116:17; Joel 2:32; and Zephaniah 3:9.
Calling on the name of the Lord, NT: Acts 9:14, 21; 22:16; 1 Corinthians 1:2; Romans 10:13; and 2 Timothy 2:22.


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Last updated August 31 at 2:50 p.m.
During the summer of 2016, the Illinois State Board of Education announced that the SAT has replaced the PARCC test for high school students. As a result, Glenbard East juniors will take the SAT with Essay on Wednesday, April 5, 2017 during the school day for free. Juniors will be able to send their SAT score reports to colleges for admissions purposes.
The PSAT/NMSQT on October 19, 2016 is designed to match the SAT. Therefore, Glenbard East High School encourages our students to register for this optional exam. Check out the "PSAT/NMSQT Benefits" below for additional reasons to take the PSAT/NMSQT.
Please note that this is the official guide from 2015. Please check back for the official guide from 2016. We will provide a link once College Board makes it available.
6. Test Prep
7. If you need to cancel an exam, log into your online PSAT Registration account.


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Bangkok - The official death toll from months of flooding in Thailand rose above 800 on Saturday, as the country's king said the damage caused by the waters was the "worst ever".
Late reporting of deaths from the inundations in central and northern provinces - now largely receded - have seen fatality numbers continue to rise, the interior ministry said.
A total of 823 flood-related deaths have now been recorded, including 10 in heavy November monsoon rains in the south of the kingdom, since the crisis began in July.
Three people are still missing.
In his annual New Year speech, King Bhumibol Adulyadej regretted the devastation caused by the deluge and sent his sympathy to those affected.
"The damage from the flood is the worst ever. It will serve as a reminder to people to be prepared because life is not always happy and people sometimes have to face hardship," he said.
At their height Thailand's worst floods in half a century affected 65 of 77 provinces in the low-lying nation, deluged hundreds of thousands of homes and forced the closure of large industrial parks, disrupting global supply chains.
The waters have since receded significantly, but more than two million people in five provinces continue to be affected and many areas still face a major clean-up operation.


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Living Well, Longer
About this Challenge
By 2050, the number of Australians aged 50 and over will have increased by more than 80 per cent - that's 6.4 million.
This Challenge headed up by Professor Lorna Moxham (pictured right) aims to examine how to live well throughout the course of our lives and what is needed to ensure a better quality of life in later years. Two of the major themes that inform Living Well, Longer are ageing and mental health. The Challenge brings together experts from a range of fields, including health, engineering, design, social science, and finance, who will address one of the key questions of Living Well, Longer:
· What do we require to maximise the mental and physical health of Australians?
· What do we need to make people mentally healthy?
· What contributes to quality of life as we age?
· What do Australians want in order to Live Well, Longer?
· What do we mean by healthy ageing?
Active Projects
Lorna and the Global Challenges team are currently working with Researchers and Stakeholders on the following projects.
Examination of the effect of a TR intervention on people's engagement with mental health services
This project will further research of Therapeutic recreation (TR) by studying the effect of a TR intervention on people's engagement with mental health services.
International Early Years Accelerometer Database – International Leadership Workshop
The project aims to utilise the International Early Years Accelerometry Database to address questions of global importance to public health policy and practice, focusing more specifically on children.
This project brings together people with mental health issues and mental health students for bush camp with the aim of providing increased support and understanding.
Research and Action to Pioneer Dementia-Friendly Communities and Organisations in Australia
The project, in conjunction with Alzheimer's Australia, will focus on the implementation of two pilot dementia-friendly communities and organisations in Australia during 2014.
University of Wollongong researchers have teamed up with The Movember Foundation to address mental health issues, such as depression, among adolescent males who play organised sport.
The project examines the interaction of the person, the environment and food & beverage packaging. This will ultimately inform the design of hospital food and beverage, as well as health policy regards food service delivery and nutrition support in healthcare.
Antimicrobial Resistance: a global challenge and a campus-wide call to arms
This project explores how we as a university community can become a centre for integrative research and policy on antimicrobial resistance.
A Pilot Study of the Relationship Between Interaction of the Caregivers and the Care Recipients of Dementia and their Anxiety in Residential Aged Care.
Disclosing invisible alcohol-related morbidity
This project aims to identify the gaps in effective assessment of alcohol related morbidity in Emergency Department at the Wollongong Hospital.
The Enablise project aims to understand the mobility issues experienced by people over the age of 55 not being adequately serviced by existing assistive mobility aids.
The Milky Way Program: a program to promote prolonged breastfeeding
This project will deliver research designed to build a mobile app that promotes and supports breastfeeding.
Dementia knowledge, Art, Research and Education (DARE)
This project utilises art as a medium by which children can express their knowledge and perception of dementia.
A practical solution to assessing future cardiovascular risk in children
This project will produce user-friendly software to implement a locally developed algorithm to pre-process hand held mobile camera images for analysis of the retinal vasculature health in children.
Increasing physical activity in ageing adults through open goals: A pilot study
This project investigates the efficacy of setting open goals to increase enjoyment, motivation, and adherence to physical activity in inactive, ageing adults.
Managing Medicines for People with Dementia
This project will pilot and evaluate a bilingual, online medication management resource designed for Italian, Macedonian and English speaking family caregivers of people living with dementia.
Medication Management Information System
This project will develop a Principled Framework for investigating Medication Management Information Systems (MMIS) for Consumers.
This project will test a UOW Developed Driving and Dementia Decision Aid (DDDA) for Consumers in the USA.
This research project aims to capture retirees' knowledge and share it with the local community through interaction between retirees, current workforce and future workforce.
Illawarra Born: Cross Generation Health Study
Illawarra Born aims to gain an insight into the health and wellbeing of a community by examining the lifespan of three generations: the pre-born baby, the parents, and the grandparents.
Health Buddy - a drone that cares
This project looks at drone-based technology to assist individuals living with chronic conditions to be able to self-manage their condition and remain at home.


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Cardiac glycosides (CG) are traditionally known as positive cardiac inotropes that inhibit Na+/K+‐ATPase‐dependent ion transport. CG also trigger‐specific signaling pathways through the cardiac Na+/K+‐ATPase, with beneficial effects in ischemia/reperfusion (I/R) injury (e.g., ouabain preconditioning, known as OPC) and hypertrophy. Our current understanding of hypersensitivity to CG and subsequent toxicity in the ischemic heart is mostly based on specific I/R‐induced alterations of the Na+/K+‐ATPase enzymatic function and has remained incomplete. The primary goal of this study was to investigate and compare the impact of I/R on Na+/K+‐ATPase enzymatic and signaling functions. Second, we assessed the impact of OPC on both functions. Langendorff‐perfused rat hearts were exposed to 30 min of ischemia and 30 min of reperfusion. At the inotropic concentration of 50 μmol/L, ouabain increased ERK and Akt phosphorylation in control hearts. In I/R hearts, this concentration did not induced positive inotropy and failed to induce Akt or ERK phosphorylation. The inotropic response to dobutamine as well as insulin signaling persisted, suggesting specific alterations of Na+/K+‐ATPase. Indeed, Na+/K+‐ATPase protein expression was intact, but the enzyme activity was decreased by 60% and the enzymatic function of the isoform with high affinity for ouabain was abolished following I/R. Strikingly, OPC prevented all I/R‐induced alterations of the receptor. Further studies are needed to reveal the respective roles of I/R‐induced modulations of Na+/K+‐ATPase enzymatic and signaling functions in cardiomyocyte death.
Cardiac glycosides (CG) such as ouabain or digoxin are specific inhibitors of Na+/K+‐ATPase activity, which results in subsequent increase in intracellular Na+, increased Na+/Ca2+ exchange, and cardiac‐positive inotropy (Lee and Klaus 1971; Schwartz et al. 1988). Ouabain binding to the α‐subunit of Na+/K+‐ATPase also initiates specific intracellular signaling pathways, most notably PI3K/Akt and c‐Src/ERK in the cardiac tissue of various species (Mohammadi et al. 2001, 2003; Liu et al. 2007; Morgan et al. 2010; Bai et al. 2013; Duan et al. 2015). Based on experimental evidence reported in recent years, the concept that these intracellular events occur at low (subinotropic) concentration and lead to additional cardiac actions of CG such as hypertrophic growth, prevention of cardiac hypertrophy and failure, and protection against ischemia‐reperfusion injury has emerged (Liu et al. 2007; Pasdois et al. 2007; Pierre et al. 2007; D'Urso et al. 2008; Morgan et al. 2010; Bai et al. 2013; Belliard et al. 2013; Duan et al. 2015; Wu et al. 2015). The most documented example of protection against ischemia‐reperfusion injury by a CG is ouabain preconditioning (OPC). OPC can be triggered by a transient exposure to a low concentration of ouabain prior to a sustained ischemia, and provides a protection against infarction and contractile defects comparable to that observed for ischemic preconditioning. Known signaling events downstream from Na+/K+‐ATPase that are critical to OPC include the activation of Src kinase and PKCε, opening of mitoK‐ATP channels, production of ROS, and activation of PI3K‐IA.
The alteration of cardiac Na+/K+‐ATPase enzyme function during ischemia and reperfusion injury is well documented (Beller et al. 1976; Kim et al. 1983; Maixent and Lelievre 1987; Lynch et al. 1988; Schwinger et al. 1999; Kjeldsen and Bundgaard 2003; Belliard et al. 2013) and is detected before cell death occurs (Inserte et al. 2005). In a model of simulated I/R in cultures of rat neonatal cardiac myocytes, we found that OPC protected Na+/K+‐ATPase catalytic properties (Belliard et al. 2013) and prevented I/R‐induced cell death. In this cell model, intrinsic Na+/K+‐ATPase enzymatic activity was protected by OPC, but the cellular uptake of the K+ congener 86Rb+ remained reduced. As potential explanations for this observation, we proposed the persistence of ouabain binding to the high‐affinity α3 isozyme expressed in rat neonatal cardiac myocytes and/or the inhibition of catalytically competent Na+/K+‐ATPase by the labile cytosolic compound described by Fuller et al. (2003). As an important implication of this finding, the fact that protection of Na+/K+‐ATPase‐mediated ion‐transport was not critical for OPC‐mediated cell survival during I/R in this model led us to propose that alteration of Na+/K+‐ATPase signaling function during I/R and protection by OPC could be involved. As a follow up, this study was undertaken to thoroughly assess how I/R and OPC impact Na+/K+‐ATPase enzymatic and signaling functions in the whole heart. The results obtained in Langendorff rat heart preparations exposed to 30 min of global ischemia followed by 30 min of reperfusion revealed marked functional changes of α2‐containing Na+/K+‐ATPase isoenzymes, with concomitant blunt of both contractile and signaling responses to ouabain but not dobutamine or insulin. Preconditioning using a subinotropic concentration of ouabain prevented ischemia‐induced alterations of Na+/K+‐ATPase enzymatic and signaling properties.
Rat heart Langendorff preparation
Experimental procedures were conducted in accordance with the Guide for the Care and Use of Laboratory Animals (NIH Publication, 8th Edition, 2011). A rat heart preparation perfused at constant flow in the Langendorff mode was used as previously described (Pierre et al. 2007). Male Sprague–Dawley rats (320–350 g, strain code 001) were anesthetized by intraperitoneal injection of sodium pentobarbital (80 mg/kg). Hearts were excised and rapidly placed into ice‐cold Krebs–Henseleit (KH) buffer. Within 40 sec, hearts were perfused in the Langendorff mode with oxygenated KH buffer containing (in mmol/L) NaCl (118.0), KCl (4.0), CaCl2 (1.8), KH2PO4 (1.3), MgSO4 (1.2), Ethylene glycol bis (2‐aminoethylether)‐N, N, N′, N′‐tetraacetic acid (0.3), NaHCO3 (25), D‐glucose (11). Isovolumic left ventricular developed pressure (LVDP) as well as end diastolic pressure (EDP) were continuously monitored during the experiment through a water‐filled latex balloon inserted into the left ventricle and analyzed subsequently using Lab Chart software (ADInstruments, Colorado Springs, CO). Hearts were paced at 4.5 Hz with bipolar electrodes attached to the left ventricle using a Grass SD9 stimulator, and pacing was maintained throughout all protocols. EDP was adjusted initially at 4–8 mmHg. After 20 min of equilibration, one of the two protocols described in the next section was initiated.
Experimental protocols
Protocol A.
To document the effect of ischemia and reperfusion on cardiac function, tissue viability, and Na+/K+‐ATPase structure and enzyme function, hearts were subjected to the 80 min‐long protocol A shown in Figure 1. Control hearts (C) were perfused with KH buffer for 80 min. Ischemia/reperfusion (I/R) hearts were perfused for 20 min with KH, then subjected to 30‐min zero‐flow (global) ischemia followed by 30 min of reperfusion. Ouabain preconditioning (OPC) hearts were perfused with KH for 8 min followed by ouabain (10 μmol/L) for 4 min and KH for 8 min before 30 min of global ischemia and 30 min of reperfusion as previously described (Pierre et al. 2007). At the end of 30 min of reperfusion, left ventricles were snap frozen in liquid nitrogen and stored at −80°C for Na+/K+‐ATPase activity measurement and western blot analysis of α1, α2, and β1 isoforms of Na+/K+‐ATPase.
Protocol B.
To investigate the effect of ischemia and reperfusion on ouabain‐induced positive inotropy and signaling, a 15 min exposure to KH or 50 μmol/L ouabain was added to one of the 80 min protocols described above (i.e., C, I/R, or OPC). A subset of hearts was exposed to 15 min dobutamine (75 nmol/L) or insulin (0.3 mU/mL) after the initial 80 min period as shown in Figure 1, and used as controls in inotropy and signaling studies.
Lactate dehydrogenase activity measurement
Coronary effluents were collected for 30 sec at time 0, 1, 2, 3, 4, 5, 10, 15, 20, and 30 min of reperfusion. Lactate dehydrogenase (LDH) activity was determined colorimetrically using a standard assay kit (Cytotoxicity detection kit (LDH), Version 8.0; Roche Diagnostics, Indianapolis, IN), according to manufacturer recommendation.
Crude heart homogenates (KCl‐enzyme preparations)
Sample preparation was performed following a tissue homogenization protocol modified from (Huang et al. 1979). Briefly, 200 mg of left ventricular liquid‐nitrogen processed tissue powder were dissolved in 10 mL of 1 mol/L KCl solution and homogenized with a Polytron PT‐10/ST for 30 sec. This method of homogenization coupled with a KCl treatment allows the disruption of the myofilament contractile proteins present in the fraction. The homogenate was passed through a double‐layered cheese cloth and centrifuged at 1000 g for 10 min. The pellet was suspended in 14 mL of 50 mmol/L KCl and 50 mmol/L Tris HCl (pH 7.4) and centrifuged again. This washing procedure was repeated twice with 50 mmol/L Tris‐HCl (pH 7.4). The final pellet was suspended in 1 mL of 1 mmol/L Tris‐EDTA (pH 7.4) and the suspension was homogenized with a Potter‐Elvehjen homogenizer. All procedures were conducted on ice and using a refrigerated centrifuge at 4°C.
Na+/K+‐ATPase activity
Na+/K+‐ATPase activity was measured by colorimetric determination of inorganic phosphate released from ATP. To insure access of substrates and inhibitor to both the ATP‐ and ouabain‐binding sites of Na+/K+‐ATPase enzymes in closed membrane vesicles that may have formed during the procedure, KCl‐enzyme preparations were pretreated with alamethicin (0.05 mg/mg of protein) for 10 min at room temperature as described previously (Xie et al. 1989). The reaction mixture for the activity assay contained 20 mmol/L Tris‐HCl (pH. 7.2), 3 mmol/L MgCl2, 100 mmol/L NaCl, 20 mmol/L KCl, 1 mmol/L EGTA‐Tris, 5 mmol/L NaN3, 2 mmol/L ATP, the KCL‐enzyme preparation, and 1 mmol/L ouabain when indicated. After addition of Mg2+/ATP, the enzymatic reaction was allowed to run for 10 min. The reaction was terminated by addition of 1 mL cold 8% trichloroacetic acid and rapid placement of each test tube on ice. Using an inorganic phosphate detection kit (Biomol Green; Enzo Life Sciences, Farmingdale, NY), released phosphate was quantified spectrophotometrically at 620 nm. For each sample, the assay was done in the presence or absence of 1 mmol/L ouabain to determine ouabain‐insensitive and total Na+/K+‐ATPase activity, respectively. Ouabain‐sensitive Na+/K+‐ATPase activity was then calculated as the difference between ouabain‐insensitive and total Na+/K+‐ATPase activity.
Effect of various concentrations of ouabain on Na+/K+‐ATPase activity
Ouabain‐sensitive Na+/K+‐ATPase activity was determined in KCL‐enzyme preparation in the presence of 10−8 to 10−3 mol/L ouabain in the reaction mixture. IC50 (50% inhibitory constant) and relative proportion of α1 and α2 isoform of Na+/K+‐ATPase was inferred from ouabain‐sensitive Na+/K+‐ATPase activity, as estimated from dose–response curves on permeabilized crude heart homogenate preparations using GraphPad PRISM Software (Version 4.00). Curves were fit to experimental data by a nonlinear regression model using GraphPad PRISM Software (San Diego, CA).
Tissue preparation, SDS‐PAGE, and Western blots
One hundred milligram of powdered left ventricle was added to an ice‐cold buffer containing 1 mmol/L EDTA, 1 mmol/L phenylmethylsulfonyl fluoride, 1 mmol/L sodium orthovanadate, 1 mmol/L NaF, 10 μmol/L okadaic acid, 10 μg/mL aprotinin, 10 μg/mL leupeptin and homogenized in a 30 mL homogenizer by repeating five times a series of eight up‐and‐down strokes separated by 30 sec intervals, and rotating for 90 min at 4°C. Lysates were then centrifuged at 16,000 × g for 15 min, and supernatants were used. Equal amount of proteins were loaded and separated by 10% SDS‐PAGE, transferred onto nitrocellulose membrane (Optitran BA‐ S 83, 0.2 μmol/L, GE Healthcare Life Sciences, Pittsburgh, PA), and immunoblotted with antibodies against Na+/K+‐ATPase α1 (α6F; Developmental studies hybridoma bank, University of Iowa, Iowa), α2 (HERED primary‐antibody; a gift from Dr T. A. Pressley, Texas Tech University HSC, Lubbock, TX), and β1 (05‐382, Upstate, CA) of Na+/K+‐ATPase subunits, phosphorylated and total Akt (T‐Akt: #9272, Cell Signaling Tech., Danvers, MA; PAkt: S 473, Cell Signaling Tech.), ERK1/2 (pERK1/2: Sc‐7383, Santa Cruz, Santa Cruz, CA; T‐ERK1/2: Sc‐94, Santa Cruz) and Src (C‐Src: Sc‐8056, Santa Cruz; pSrc: 44660G, Thermofisher Scientific, Waltham, MA). GAPDH (Sc‐20357; Santa Cruz) was probed as a loading control. Rabbit (Sc‐2004; Santa Cruz), goat (Sc‐2020; Santa Cruz), and mouse (Sc‐2005; Santa Cruz) secondary antibodies were used in this study. Protein bands were detected using chemiluminescence and enhanced chemiluminescence, and quantified using Image J software (NIH, Bethesda, DC).
Statistical analysis
All values are expressed as mean ± SEM. Comparisons between groups were conducted using a one‐way ANOVA followed by a multiple comparison post hoc test. When two groups were compared, unpaired bilateral Student's t test was used. P < 0.05 was considered statistically significant.
Impact of I/R and OPC protocols on contractile function and tissue injury
The contractile performance of control hearts assessed by real‐time recording of LVDP and EDP was stable over 80 min of protocol A (Fig. 1), as shown in Figure 2A and B. In contrast, 30 min of ischemia followed by 30 min of reperfusion resulted in a 68% decrease in LVDP at 80 min compared to preischemic value (106 ± 7 mmHg vs. 35 ± 3 mmHg, P < 0.001), and a significant increase in EDP (3 ± 2 mmHg vs. 71 ± 5 mmHg, P < 0.001). OPC resulted in a significantly better recovery of LVDP (76 ± 5 mmHg vs. 35 ± 3 mmHg; P < 0.001) and EDP (34 ± 5 mmHg vs. 71 ± 4 mmHg; P < 0.001) at 80 min compared to I/R. As shown in Figure 2C, the protective effect of OPC was also associated with a 70% reduction in LDH release (0.08 ± 0.03 U/mL vs. 0.18 ± 0.03 U/mL; P < 0.05). Taken together, the above findings were consistent with our early report of OPC‐induced protection in this model (Pierre et al. 2007).
Na+/K+ ATPase structure and enzyme function
As shown in Figure 3A, the ouabain‐sensitive activity corresponding to Na+/K+‐ATPase in alamethicin‐treated KCl preparations from control hearts was 7.4 ± 0.8 μmol Pi/h/mg of protein. After 30 min of ischemia and 30 min of reperfusion, Na+/K+‐ATPase was decreased by 66% (2.5 ± 0.6 μmol Pi/h/mg of protein; P < 0.001 vs. control) and significantly protected by OPC (P < 0.05 vs. I/R). Na+/K+‐ATPase in adult rat hearts typically exhibit a biphasic dose–response curve to ouabain, with a low‐affinity site attributed to α1‐containing isoenzymes, and a high‐affinity component attributable to α2‐containing isoenzymes (Maixent et al. 1999). As expected, the log concentration–effect curves were biphasic for control hearts in this study, as shown in Figure 3B (C). As represented by the solid line, dose–response curves were best modeled assuming two computed IC50 (ouabain concentration leading to 50% inhibition) of 5.9 × 10−8 mol/L and 9.1 × 10−5 mol/L, with respective contributions of 33% and 67% (Table 1). In contrast, dose–response curves from I/R hearts were best fitted assuming one IC50 rather than two, resulting in a monophasic curve (I/R). The computed IC50 of the remaining site was 1.8 × 10−5 mol/L, suggesting a loss of the high‐affinity site. OPC protected the activity of the site of high affinity, as suggested by the biphasic curve. Contributions of the two isoenzymes were 64% for the site of low affinity (α1) and 36% for the site of high affinity (α2). As shown in Figure 4, I/R‐induced alterations of Na+/K+‐ATPase activity and loss of high‐affinity enzymatic site or OPC protection were not accompanied by any detectable change in total cardiac Na+/K+‐ATPase α1, α2 or β1 protein contents as determined by Western blot analysis.
Effect of ouabain 50 μmol/L on contractility and signaling
We next evaluated the impact of I/R on positive inotropy and signaling induced by 50 μmol/L of ouabain. This relatively high concentration was selected because it is known to trigger a robust‐positive inotropic effect without signs of toxicity, as well as a clear activation of Na+/K+‐ATPase signaling in Langendorff preparations of rat hearts (Mohammadi et al. 2003). The effects in control, I/R, and OPC hearts were compared on LVDP to monitor changes in the force of contraction, and ERK and Akt phosphorylation as markers of activation of Na+/K+‐ATPase‐mediated signaling. As expected, a 15 min exposure to ouabain 50 μmol/L according to protocol B (Fig. 1) induced a robust and significant increase in LVDP in control hearts (95 ± 6 mmHg to 126 ± 3 mmHg; P < 0.05 vs. C, Fig. 5). Also expected, the I/R protocol resulted in a significant decrease in LVDP compared to control. After I/R, exposure to ouabain 50 μmol/L for 15 min failed to induce positive inotropy (Fig. 5). Exposure to 75 nmol/L of the β1 adrenergic agonist dobutamine, which produced a positive inotropic response comparable to ouabain 50 μmol/L in control hearts (136 ± 1 mmHg), still produced a significant increase in contractility in the I/R hearts (56 ± 4 mmHg; P < 0.05 vs. 38 ± 2 mmHg in I/R), suggesting that the contractile apparatus of myocytes in I/R hearts was able to respond to inotropic stimuli other than ouabain.
As shown in Figure 6A (left panel), ouabain 50 μmol/L resulted in a robust increase in Akt Ser‐473 phosphorylation in control hearts (2.44 ± 0.29 in OUA vs. 1.04 ± 0.11 in C; P < 0.01), but not in I/R hearts (Fig. 6A, right panel). Similarly, ouabain 50 μmol/L significantly increased ERK1/2 phosphorylation in control hearts (1.00 ± 0.07 vs. 2.77 ± 0.17; P < 0.05), but not in I/R hearts. To test whether the lack of Akt response to ouabain in I/R hearts resulted from a general defect of Akt pathway after I/R, insulin 0.3 mU/mL was used according to Protocol B (Fig. 1). As shown in Figure 5 (blue bars), this treatment did not significantly affect LVDP in control or I/R hearts, but induced a robust activation Akt Ser‐473 phosphorylation in both control and I/R hearts (Fig. 6C). OPC preserved inotropic and signaling response to ouabain 50 μmol/L. Indeed, a significant increase in LVDP was observed (64 ± 7 mmHg vs. 100 ± 11; P < 0.05; Fig. 5), which was accompanied by a significant increase in pAkt/Akt and pERK1/2/ERK1/2 ratios (Fig. 7).
In Langendorff‐perfused rat heart preparations, we examined how I/R impacts Na+/K+‐ATPase‐mediated signaling in response to 50 μmol/L of the CG ouabain. Na+/K+‐ATPase structure, signaling and enzyme function, as well as cardiac contractile function were evaluated. The results suggest that I/R induces isoform‐specific Na+/K+‐ATPase alterations, which in turn modulate ouabain inotropic and signaling response in the ischemic heart. They further revealed that OPC provides protection against all I/R‐induced alterations of Na/K‐ATPase functions.
I/R‐induced alteration of Na+/K+‐ATPase isoenzymes and protection by OPC
Numerous studies including ours have shown decreased sodium pump activity in cardiac tissue subjected to I/R (Beller et al. 1976; Inserte et al. 2005; Singh et al. 2012; Belliard et al. 2013). In this study, Na+/K+‐ATPase in crude homogenates was reduced by over 60%, without detectable changes in total protein expression of Na+/K+‐ATPase α1, α2 or β1 (Figs 3A and 4). This is in keeping with results from our recent study in rat neonatal cardiac myocytes (Belliard et al. 2013), as is the complete protection provided by OPC. In the adult rat cardiac tissue, it is well established that α1 represents 80% of the Na+/K+‐ATPase catalytic‐subunit expressed, and has a low affinity for ouabain. Na+/K+‐ATPase α2 represents the remaining 20%, with a higher affinity (Lucchesi and Sweadner 1991; Gerbi et al. 1997). Consistently, ouabain dose–response curves were best fitted to a model with two phases of inhibition in control hearts, with a major contribution of the component of low affinity (Table 1). Strikingly, ouabain inhibition curves were no longer biphasic in postischemic hearts (Fig. 3B). The unique inhibitory constant was of low affinity, and the function of the high‐affinity component related to α2‐containing isoenzymes was no longer detected. Mechanistically, a combined exposure to high levels of reactive oxygen species (ROS) and Ca2+ during I/R could explain these isoenzyme‐specific alterations without change in total protein expression. Indeed, ROS preferentially alter α2‐mediated Na+/K+‐ATPase activity compared to α1 (Xie et al. 1990, 1995) a selectivity that is most likely based on structural features. It has also been known since the 1980s that Ca2+ levels critically affect ouabain dose–responses of cardiac Na+/K+‐ATPase. Specifically, the function of the component of high affinity is lost at supraphysiological concentrations (Mansier and Lelievre 1982; Lelievre et al. 1984). While all preparations were perfused using a physiological concentration of 1.5 mmol/L Ca2+ in this study, a substantial I/R‐induced increase in Ca2+ likely explains, at least in part, the monophasic ouabain dose–response in I/R hearts. Irrespective of the mechanism involved, this study also revealed that OPC prevented these I/R‐induced isoform‐specific alterations.
Contractility and signaling response to CG in the I/R heart
After I/R, positive inotropy was observed in response to dobutamine but not ouabain (Fig. 5). Rather, ouabain 50 μmol/L further reduced LVDP, an adverse effect suggestive of toxicity. Indeed, although arrythmogenic effects of toxic concentrations of CG after I/R (Kim et al. 1984; Lynch et al. 1986) were not observed in our electrically paced preparations, an increase in EDP was frequently observed upon addition of ouabain in I/R hearts, suggestive of Ca2+ overload (not shown). Since LVDP was calculated as the difference between LVSP and EDP, this in turn contributed to a decrease in LVDP compared to I/R alone (Fig. 5). According to the model proposed by Maixent and Lelievre (1987) the loss of inotropic response and the toxic effect of 50 μmol/L ouabain after I/R are direct consequences of I/R‐induced alterations of Na+/K+‐ATPase enzymatic properties. In their model, the component of high affinity for ouabain (α2) is responsible for the inotropic response, whereas inhibition of the component of low affinity (α1) mediates the toxic effect. Consequently, the I/R‐induced loss of function of α2 with increased contribution of α1 (see Table 1) led to the observed ouabain‐specific loss of inotropic effect and toxicity (Maixent and Lelievre 1987; Maixent et al. 1987). In terms of signaling, Akt phosphorylation persisted in response to insulin (Fig. 6C), but Akt and ERK phosphorylation no longer occurred upon exposure to 50 μmol/L ouabain after I/R (Fig. 6B), suggesting that ouabain signaling was specifically altered. OPC effectively protected Akt and ERK responses to ouabain (Fig. 7).
Taken together, these findings indicate that both enzymatic and signaling functions of Na+/K+‐ATPase are specifically altered in the ischemic heart, and that OPC preserves all parameters. Two main questions remain to be addressed. First, further studies are needed to assess the role of Na+/K+‐ATPase nonenzymatic function in I/R‐induced cardiac myocyte cell death. Indeed, our previous study in rat neonatal cardiomyocytes provided indirect evidence that I/R‐induced disruption of Na+/K+‐ATPase ‐driven ion transport may not be the primary cause of I/R‐induced cell death (Belliard et al. 2013). This was based on the observation that OPC decreased I/R‐induced cardiomyocyte death without observable protection of Na+/K+‐ATPase‐mediated ion transport (assessed by ouabain‐sensitive 86Rb+ uptake), and led us to propose that an I/R‐induced effect on the nonenzymatic function of Na+/K+‐ATPase may occur. This study provides the first evidence that at least some of Na+/K+‐ATPase‐mediated signaling pathways are indeed specifically disrupted by I/R and protected by OPC, which warrants further studies of possible mechanism involved.
Conflict of Interest
None declared.
Funding Information
This work was supported by National Heart, Lung, and Blood Institute Grant HL‐36573 and by the Marshall Institute for Interdisciplinary Research.
- Manuscript Received: August 16, 2016.
- Manuscript Revised: September 9, 2016.
- Manuscript Accepted: September 12, 2016.
- © 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.


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Category:Nations at the 1952 Winter Olympics
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Unique Sculptural Art Glass Makes The Perfect Statement
Our unique sculptural art glass makes the perfect statement in an overall project. Many clients contact us for one or two 'key' pieces they need to complete a larger project. The impact of one or two well chosen works of art can be the perfect solution to elevate the ambiance of an environment. We worked with ArtLink, an international art consultancy located in Tel Aviv, for their art design project on-board Holland American Line's newest and largest cruise ship – MS Koningsdam. The photos from their project show work from our Blue Color Collection of glass sculpture,...Read More
Vilano in jade
An asymmetrical yet balanced approach with the Vilano in jade is used when incorporating the visual elements. The transparent portion of this glass sculpture has been sandblasted to create a translucent look. shown in jade color size: 23″ x 9″ x 5″ $2650.Read More
Vilano in yellow
The Vilano in yellow retains the qualities of glass through the capture of the surrounding light. Sandblasting is the process that is used to achieve the translucent quality within this hand blown glass work. shown in yellow color size: 23″ x 9″ x 5″ $2650.Read More
Vilano in red
The Vilano in red displays a combination of a textured opaque color and the glow of the translucent segment creating a dynamic contrast within this glass sculpture. The translucent scarlet color is created by sandblasting the surface during the cold working process. shown in red color size: 23″ x 9″ x 5″ $2650.Read More
Vilano in cinnamon
The Vilano takes an asymmetrical yet balanced approach incorporating its visual elements in this hand blown glass sculpture. This bipartite color scheme incorporates a translucent sandblasted area to compliment the opaque cinnamon glass color. shown in the cinnamon color size: 23″ x 9″ x 5″ $2650.Read More


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What Is Reputation Management?
Reputation management is a way to stay in control of your online persona. It is mainly used to erase or downplay any bad reviews or negative comments made to disparage a business or individual. This includes information on legal matters such as bankruptcies or arrests with no convictions, unflattering photos or mug shots and video leaks. It works to eliminate or devalue any counterproductive online information. Reputation management incorporates several different approaches to accomplish this.
Most businesses and individuals can be found online and there is typically an ample amount of information available. When a searcher needs to find a specific business or person, they will almost always make use of a search engine like Google. Unfortunately, some adverse evaluations may appear ahead of any positive information about a business or person and to make matters worse, it may not even be accurate. This can cost individual jobs or can affect relationships and a business can lose customers and a substantial amount of money.
If these bad reviews or comments are not true, reputation management can make the web page take the information down. If there is no way to do this, they can make the content less noticeable. They do this by consistency adding new uplifting and accurate material to make the negative content less apparent. For example, if a company has a bad review reputation management may highlight several good reviews and place them on a review web page. Or, if an individual has a less than favorable photo that is online, they can present the person's accomplishments or proficiencies in other areas, to counteract the unflattering photo. This forces the negative content to be pushed back in the search engine rating, so that it is virtually unseen.
By doing this, an individual or business can fully recover from the online attack and have a more favorable reputation. Agents working for OvernightReputation.com will almost always continue to monitor their client online making sure that their reputation stays intact. They can also give businesses tips on how to present themselves in a more positive way and even how to monitor them selves. This gives an individual or businesses complete control over their online profile.


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Today, I'm hanging out over at Brenda Cothern's blog. She's having a special Sizzling July series and... she had me over for an interview.
I had a nervous. I've never been interviewed before. Teehee, it's kinda cool. Lil'ol'me, being interviewed. That rocks.
I'm over there from July 1st-3rd. Come visit me :D :D
My Freia me is having a jewelry anniversary sale in my Etsy store. It's my 6 month, I mean my 7 month, anniversary so I made a sale. :D
It's 15% off of all my in Etsy stock (excludes custom/made to order pieces) with the coupon code 6moyayme.
Tomorrow, Tal Valante is coming over to mah Place to visit for her All My Crimes tour.
Sittin' for a chitchat and bringing a cool giveaway.
Aaaaand... I think that's all for now.
Oh! No. Wait. Mah Scarlet & the White Wolf by Kirby Crow giveaway. That's still going on too.
It closes the 3rd, so if you've not yet entered, you totes should. That book is fantabulous!
'k. I think that's all. For now.
Later taters!


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Blue Crow Media have teamed up with the Twentieth Century Society and photographer Simon Phipps to bring you the Brutalist London Map. The guide features over 50 leading examples of Brutalist architecture from the National Theatre and Southbank Centre, the Barbican and Trellick Tower to lesser known buildings like the Elephant and Rhinocerous Pavilion at London Zoo, Hyde Park Barracks and Keeling House in Bethnal Green. Details for each building include the location, date, the architect or practice responsible and listing status.
Henrietta Billings, Senior Conservation Adviser, Twentieth Century Society said:
"This map is a fantastic opportunity to highlight some of London's boldest and exciting post war buildings. Ten years ago this style of architecture was completely out of fashion, but now more and more people can see what's great about these buildings. The map will help you find more examples than you ever knew existed."
Two sided with a map on one side and text and photos on the other, it opens to 420mm x 600mm and folds down to 210mm x 150mm, and is protected by wide band. Priced at £8 plus shipping, it is available to buy online and at Foyles, RIBA's shop and Stanfords.
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Special guest host, Dr. Amir Barzin, Resident Physician at UNC Family Medicine, will join Cristy to talk with Chair of the Department of Health Law, Bioethics & Human Rights of Boston University School of Public Health, Professor George Annas about Life at Guantanamo: the Unspoken Truth.
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Listen to the show!


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Your On-Line Guide to
The Healing Energies, Metaphysical Properties,
Legendary Uses and Meaning
Introduction to the Meaning and Uses of Amethyst
Purple Amethyst has been highly esteemed throughout the ages for its stunning beauty and legendary powers to stimulate, and soothe, the mind and emotions. It is a semi-precious stone in today's classifications, but to the ancients it was a "Gem of Fire," a Precious Stone worth, at times in history, as much as a Diamond. It has always been associated with February, the month the Romans dedicated to Neptune, their water-god, and is the traditional birthstone of that month. It is the stone of St. Valentine and faithful love, and signifies ecclesiastical dignity as the Bishop's Stone. It carries the energy of fire and passion, creativity and spirituality, yet bears the logic of temperance and sobriety. [Fernie, 170-171][Mella, 73][Eason, 212]
Whether its crystals are left natural, polished as tumblestones, or faceted into magnificent jewels, Amethyst is a gem whose beauty transcends its commonality. It is a variety of Quartz found in many locations around the world, and forms as transparent, terminated crystals of all sizes in geodes, clusters and as long single terminations. It is also found in vitreous masses and polished into wonderful specimens and personal talismans. The presence of manganese in clear Quartz produces Amethyst, while additional amounts of iron vary the purple coloration. Amethyst ranges in hue from pale red-violet to deep violet, and may be transparent or opaque. It is sometimes layered with white Quartz as Chevron Amethyst, found in combination with Cacoxenite, mixed with Citrine as Ametrine, or in rare cases, "rutilated" with Goethite. (See paragraphs below.) [Melody, 109][Hall, 53]
The name Amethyst derives from the Greek word ametusthos, meaning "not intoxicated," and comes from an ancient legend. The wine god Bacchus, angry over an insult and determined to avenge himself decreed the first person he should meet would be devoured by his tigers. The unfortunate mortal happened to be a beautiful maiden named Amethyst on her way to worship at the shrine of Diana. As the ferocious beasts sprang, she sought the protection of the goddess and was saved by being turned into a clear, white crystal. Bacchus, regretting his cruelty, poured the juice of his grapes over the stone as an offering, giving the gem its lovely purple hue. [Megemont, 24][Kunz, 58-59][Simmons, 28] (See the Legends and Lore section for an alternate version.)
Throughout history the special virtue of Amethyst has been that of preventing drunkenness and overindulgence. Ancient Greeks and Romans routinely studded their goblets with Amethyst believing wine drunk from an Amethyst cup was powerless to intoxicate, and a stone worn on the body, especially at the navel, had a sobering effect, not only for inebriation but in over-zealousness in passion. Catholic bishops also wore Amethyst in a ring to protect from mystical intoxication. Kissing the ring kept others from similar mystical intoxication and kept them grounded in spiritual thought. [Fernie, 169-170][Kunz, 58][Mella, 73][Megemont, 24-25]
Amethyst was also reputed to control evil thoughts, increase intelligence and render men shrewd in business matters. For travelers it was worn as a protection from treachery and surprise attacks, kept soldiers from harm and gave them victory over their enemies. It lent assistance to hunters in the capture of wild beasts and fowl, and was considered to be a powerful psychic stone of protection against witchcraft and black magic. Like other royal stones it protected its wearer from disease and contagion. [Kunz, 58][Fernie, 170][Mella, 72-73]
In the spiritual world, Amethyst provided a connection to the Divine. To the Hebrews, it was Ahlamah, the ninth stone in the breastplate of the High Priest, engraved with the tribe of Dan, as well as the twelfth foundation stone for the New Jerusalem. To the Egyptians, it was Hemag, listed in the Book of the Dead to be carved into heart-shaped amulets for burial. In Eastern cultures, it was listed in descriptions of sacred "gem-cities," "trees of life," and used in temple offerings for worship, and to align planetary and astrological influences. It was popular in rosaries and prayer beads, credited with creating an atmosphere of pious calm, imbuing a sense of mental peace and quietude. [Kunz, 236-243, 297, 302-202][Fernie, 169]
In today's world, Amethyst is still a remarkable stone of spirituality and contentment, known for its metaphysical abilities to still the mind and inspire an enhanced meditative state. Its inherent high frequency purifies the aura of any negative energy or attachments, and creates a protective shield of Light around the body, allowing one to remain clear and centered while opening to spiritual direction. Amethyst stimulates the Third Eye, Crown and Etheric Chakras enhancing cognitive perception as well as accelerating the development of intuitive and psychic ability. It initiates wisdom and greater understanding, and is a stone of comfort for those grieving the loss of a loved one. [Melody, 109][Simmons, 28][Ahsian, 29][Raphaell, 80]
Amethyst's ability to expand the higher mind also enhances one's creativity and passion. It strengthens the imagination and intuition, and refines the thinking processes. It helps in the assimilation of new ideas, putting thought into action, and brings projects to fruition. It is a talisman of focus and success. [Megemont, 25]
In nature, Amethyst at times forms in combination with other minerals. In addition to the properties of Amethyst outlined in this article, the following varieties possess additional qualities.
Chevron Amethyst displays v-shaped chevrons of deep purple and white Quartz that "seep" into beautiful layers. It is one of the finest Third-Eye stones for stimulating vision within the self as well as the physical world, filtering the life force from the cosmos via the Crown in its white layers and opening up spiritual and psychic channels through the purple. It has a strong, focused energy for dissipating and repelling negativity, and is the perfect crystal for learning any form of spiritual healing. Hold one in each hand for powerful but safe out-of-body travel, shamanic journeying or pathworking, and between the hands while praying or reciting mantras. [Eason, 310][Hall, 56][Melody, 112]
Cacoxenite in Amethyst mingles dark brown to yellow tufts of Cacoxenite, a phosphate mineral and major component in the Super Seven crystal, with the host crystal Amethyst. This combination brings a high level of creativity and new ideas to humanity by fostering thoughts that have never been thought of before. It is a calming stone, good in times of upheaval, and raises spiritual awareness of the creator essence in the beauty of nature and the kindness in people. Carry on the night of the crescent and full moon to transfer healing energy to the Earth and create an ethereal connection between all of the universe. [Eason, 105][Melody, 177]
Ametrine is a combination of Amethyst and Citrine within the same crystal, a harmonious blend of the two energies. It brings spirituality into harmony with the intellect and inspires a profound flow of creativity, new ideas and insights. It is a remarkable healing stone, removing pain and tension while bringing energy and a sense of well-being to the mind and body. It brings greater focus in meditation, protection in astral travel and is a gateway crystal for opening angelic or spirit guide contact. Leave in natural light from noon on the day of a full moon and through the night to catch lunar rays then carry on the person to bring luck in money ventures. [Simmons, 30][Eason, 311][Melody, 114]
"Rutilated" Amethyst is a rare form of Amethyst which appears to contain Rutile, but actually contains brownish crystals of Goethite, an iron hydroxide mineral also found in the Super Seven crystal. Goethite is a stone for finding the link between the deep self and Earth, and together with Amethyst clears the Earth and Base Chakras, aligning the whole chakra system to the higher mind. It purifies the emotional body and is particularly helpful in grief work. It facilitates clairaudience, communion with angels, and connections with other worlds. To program as a wishing stone or with intentions, messages, and prayers, simply hold the stone with the intent in mind. [Melody, 111, 297][Hall II, 143][Ahsian, 178]
Amethyst is an exceptional crystal for wearing on the body, for use in healing rituals, and for enhancing one's environment. It has been known to fade in direct sunlight and care should be taken. It is also good to clear its energies from time to time by holding the stone under running water for a short period while affirming that the stone be cleared. Keep unpolished Amethyst near other crystals to recharge them. [Hall, 55][Ahsian, 28][Eason, 212]
Amethyst Uses and Purposes – Overview
Amethyst is a wonderful talisman for use in the creative arts, especially in darker shades. It assists endeavors where new, original results need to be created using tools and methods of the past. It is often used as the Artist's Stone, the Composer's Stone, the Inventor's, Poet's and Painter's Stones. Keep an Amethyst crystal or cluster in the area to focus and amplify the creative elements of the Universal Life Force.
Called the "All-healer," Amethyst is one of the most effective crystals for healing people, plants and animals. Natural unpolished Amethysts or geodes are particularly helpful placed where plants will not grow or animals refuse to sit. It also counteracts negative earth energies beneath buildings or anywhere that feels hostile. [Eason, 212][Hall, 54]
Amethyst protects against psychic attack, paranormal harm or ill-wishing, and returns the energy back to the universe after being transformed into positive, loving energy. To increase this power and attract good luck, draw an image of the sun and the crescent moon over an Amethyst in lavender incense smoke. [Melody, 110][Eason, 212]
Referred to as "nature's tranquilizer," Amethyst calms and soothes, assisting the transmission of neural signals through the brain. It relieves obsessive compulsive disorder and hyperactivity in children and animals. Place under the pillow or mattress, or rub the center of the forehead counter-clockwise to cure insomnia and stimulate pleasant dreams. It is especially effective for children's recurring nightmares and fears of the dark, and may help alleviate homesickness. [Eason, 212][Hall, 54][Megemont, 25]
Amethyst is an excellent stone for diplomats, negotiators and business people. It calms angry temperaments and gives a distinct advantage in situations where debating is required. Wear or hold Amethyst to bring in spiritual insights coupled with intellectual reasoning. [Megemont, 26][Melody, 111] As a luck and prosperity crystal, Amethyst is good for reducing the tendency to overspend, gambling addictions or unwise investments.[Eason, 44]
Amethyst is connected to the Temperance card in the tarot, representing balance. It is a stone dedicated to curbing overindulgence and bad habits, and is an excellent aid to quitting smoking, drinking and drug use, as well as unhealthy physical passion. It also provides the strength needed to obtain freedom from addictive personalities, one's own or another's. Placing an Amethyst on the navel is believed to protect a person from intoxication, and in conjunction with other treatments such as counseling, helps cure addictions. A naval piercing makes it possible to always keep an Amethyst in this spot. [Megemont, 25][Simmons, 28][Melody, 110]
Amethyst is the stone of St. Valentine and of faithful lovers because St. Valentine was thought to have worn an Amethyst ring engraved with the image of Cupid. It is also referred to as the "couple's stone" and gives meaning to relationships that over time, transcends the carnal union and gives way to deeper connection and a more soulful communion. Wear as an engagement or eternity ring for fidelity, or as a locket to call back lost love. [Eason, 212][Megemont, 25]
Amethyst Healing Therapies – Overview
(Please note: Information on this web site is no substitute for consulting a health care professional. All information contained on this web site, including information relating to medical and health conditions, products and treatments, is for informational purposes only. Please see your doctor or health care professional before starting any alternative treatments, diets, supplements or exercise programs.)
Amethyst has healing powers to help with physical ailments, emotional issues, and in Energy Healing and Chakra balancing. Amethyst crystal therapies are primarily associated with physical ailments of the nervous system, the curing of nightmares and insomnia, and balancing the crown chakra. The therapeutic uses of Amethyst have a long and well-documented history.
Amethyst Physical Healing Energy
Amethyst boosts the production of hormones, and stimulates the sympathetic nervous system and endocrine glands to optimum performance. It supports oxygenation in the blood, and aids in treatments of the digestive tract, heart, stomach, and skin. Amethyst also strengthens the immune system and reduces bruising, pain and swellings. It has been used with excellent results as an elixir in the treatment of arthritis. [Melody, 111][Hall, 55][Gienger, 13]
Amethyst is thought to relieve the symptoms of tinnitus and other hearing disorders, and is highly beneficial in treating insomnia, especially when caused by an overactive mind. It is calming and soothing to the neural impulses in the brain. Its energy ameliorates the pain of headaches and migraines, and reduces stress and nervous tension. It may be used to treat psychic disturbances and to stabilize brain imbalances, but should not be used in cases of paranoia or schizophrenia. [Hall, 54-55][Melody, 111][Megemont, 25][Ahsian, 30]
Amethyst Emotional Healing Energy
Amethyst is especially supportive of the emotional body, bringing those who are overworked, overstressed, or overwhelmed back to center. It eases the mental anxieties that lead to physical tension and headaches, and is a great crystal to calm those who tend to be hot-headed and easily angered. [Raphaell, 80][Gienger, 13]
Amethyst helps in identifying the root causes behind one's negative behaviors, habits and emotional patterns that create imbalance and disease. It also helps one understand the reality of cause and effect in behavior, and assists in better decision making. Amethyst is a marvelous aid in overcoming addictions by counteracting the effects of drugs and alcohol on brain function, while imparting its own peaceful sustaining energy.[Ahsian, 29][Hall, 54]
Because Amethyst initiates wisdom and greater understanding, it is a comforting crystal for those grieving the loss of a loved one. Its presence communicates that there is no death, only transitioning and changing of forms. It encourages the release of sorrow, and rejoicing in a loved one's spirit being freed from the confinement of the physical body. Called "the soul stone," Amethyst assists in understanding and connecting to the eternal existence of the soul and initiates one's own deep soul experiences. It is an ideal crystal to hold or meditate upon during the death experience, of another or oneself, allowing the release of the temporal physical body with more ease, assuredness and peace. It is a perfect stone to gift to those with terminal illnesses or to use in preparation for a conscious death experience. [Raphaell, 80][Gienger, 13]
Amethyst Chakra Healing and Balancing Energy
Amethyst carries a high, sweet energy, particularly stimulating to the Third Eye, Crown and Etheric Chakras. [Ahsian, 29]
The Brow Chakra, also called the Third Eye, is the centre of our perception and command. It directs our sight and everyday awareness of the world. Our consciousness is located here, and we relate to ourselves through this chakra. When the Brow Chakra is in balance our thoughts and internal communications within ourselves are healthy and vibrant. We are open to new ideas, dreams, and visions, and can control the flow of energy within all the chakras. The dark blue/purple crystals of indigo are used to treat imbalances of the Brow Chakra. It is a quiet color, one of mystery and wisdom and judgment.
The Crown Chakra is located at the top of the head, and is our gateway to the expanded universe beyond our bodies. It controls how we think, and how we respond to the world around us. It is the fountainhead of our beliefs and the source of our spirituality. It connects us to the higher planes of existence and is the source of universal energy and truth. When the Crown is in balance, our energies are in balance. We know our place in the universe and see things as they are. We are unruffled by setbacks, knowing they are an essential part of life. Imbalances of the Crown Chakra are treated with Light Violet crystals. Their violet rays have the universal life force of magic, dreams, inspiration, and destiny.
The higher vibrational White and Lavender/White crystals are associated with the Higher Crown, Soul Star and Stellar Gateway Chakras. They are attuned to higher, more spiritually enlightened things, and embody true humility. They provide a soul connection and the highest self-illumination, as well as a cosmic doorway to other worlds. [Hall II, 366] They represent personal identification with the Infinite, and oneness with God, peace and wisdom. [Raphell, 164]
Amethyst in Ancient Lore and Legend
According to Ovid, the Roman poet, Amethyst was a nymph pursued by Bacchus. Desperate to escape him, she called on the goddess Diana who rescued her by transforming her into a shiny stone of "pure, cold crystal." Furious, Bacchus threw his glass filled with wine on the stone giving it its purple color. [Megemont, 25] There are various stories and sources for this legend, sometimes with Bacchus, the Roman god of wine, sometimes with Dionysus, the Greek god of intoxification. All credit wine as the reason for the crystal's hue.
The use of Amethyst can be traced as far back as 25,000 B.C. to the Neolithic people in Europe. Its spiritual and legendary energies made it popular for beads and amulets in many cultures, and later as a stone of royalty it was utilized in crowns, scepters and jewelry. Ancient Egyptians used Amethyst as a healing stone to ease fears and guilt, and as a strong protector while traveling. Greeks and Romans used it constantly to protect themselves from excesses of overindulgence with food and drink, and its powerful healing effect upon the mind made it valuable for placement under the pillow at bedtime to cure insomnia and induce pleasant dreams. For headaches it was warmed and placed on the forehead or temples to reduce throbbing. [Simmons, 28][Mella, 72-73]
Amethyst was considered a powerful psychic stone of protection against witchcraft and black magic, and was said to lose its color and turn pale when placed near an angry attacker. [Mella, 73]
The Peruvians held a belief that if the names of the sun and the moon were engraved on an Amethyst and hung around one's neck with a baboon's hair, or a swallow's feather, it would act as a spell against witchcraft. [Fernie, 170] The ancient philosopher Pliny the Elder claimed an Amethyst engraved with figures of the sun and the moon immunized people against poisons. [Megemont, 25]
A bear engraved on an Amethyst had the virtue of putting demons to flight, and defended and preserved the wearer from drunkenness. [Kunz, 134]
In folklore, Amethyst was thought to deter animal fleas. [Eason, 5]
It was once believed a person could summon any love by speaking his or her name in an Amethyst, even if the person was committed to another. [Eason, 212]
Amethyst, listed as the twelfth foundation stone of the New Jerusalem, was considered by some to be inscribed with the name of the apostle Matthew, and was emblematic of his conversion and sobriety. [Fernie, 44] Andreas, bishop of Caesarea, in the tenth century believed the Amethyst, with its fiery aspect, signified Matthias, who in the gift of tongues was so filled with celestial fire and zeal to please God who had chosen him, that he was found worthy to take the place of Judas. [Kunz, 313]
The Rosicrucian society, who combined pagan with Christian types and figures, saw Amethyst and its color as a symbol of the divine male sacrifice, since the stone and color were typical of love, truth, passion, suffering and hope. The love of Christ led him to make the ultimate sacrifice and suffer the agony of the cross, and the crucifixion was followed by the resurrection; thus came the hope of mankind to enjoy eternal happiness in heaven. [Kunz, 269-270]
Amethyst, the stone of February, should also be worn on Thursdays, "Thor's Day." [Fernie, 171] It is considered a Gem of Spring, and though historically given as a gift on the seventeenth wedding anniversary, it is now listed as the official anniversary gemstone for the sixth anniversary.[Kunz, 326, 337][Eason, 45]
Footnote References
The symbols [ ] enclose the author's name and a page number for a reference cited from the following books:
[Ahsian, pp.] Robert Simmons & Naisha Ahsian, The Book of Stones (Berkley, CA: North Atlantic Books, 2007).
[Eason, pp. ]Cassandra Eason, The New Crystal Bible (London: Carlton Books Ltd., 2010).
[Fernie, pp.] William T. Fernie, The Occult and Curative Powers of Precious Stones (Blauvelt, NY: Rudolph Steiner Publications, 1973).
[Gienger, pp.] Michael Gienger, Healing Crystals (Scotland: Earthdancer Books, 2009).
[Hall, pp.] Judy Hall, The Crystal Bible (Cincinnati, OH: Walking Stick Press, 2003).
[Hall 2, pp.]Judy Hall, The Crystal Bible 2 (Cincinnati, OH: Walking Stick Press, 2009).
[Kunz, pp.] George Frederick Kunz, The Curious Lore of Precious Stones (New York: Dover Publications, 1971).
[Megemont, pp.] Florence Megemont, The Metaphysical Book of Gems and Crystals (Rochester, VT: Healing Arts Press, 2008).
[Mella, pp.] Dorothee L. Mella, Stone Power II (Albuquerque, NM: Brotherhood of Life, Inc., 1986).
[Melody, pp.] Melody, Love Is In The Earth (Wheat Ridge, CO: Earth-Love Publishing House, 1995).
[Raphaell, pp.] Katrina Raphaell, Crystal Enlightenment (Santa Fe, NM: Aurora Press, 1985)
[Simmons, pp.] Robert Simmons & Naisha Ahsian, The Book of Stones (Berkley, CA: North Atlantic Books, 2007).


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Update Received November 2009: Anuk is the best puppy ever. He has fit seamlessly into my household. Axel, my GSD, loves him, and finally has someone who will play with him! He's a pro at adjusting his play style to whomever he's playing with. He plays gently with smaller or shy dogs, but will rough and tumble with the rowdys, no problem! I take him to both of my jobs with me, and everybody is totally in love with him. He's everyone's friend - human and dog alike. I absolutely LOVE HIM! Thank you, All Dog Rescue.
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Last Wednesday, BMW accepted two Ward's Automotive Group awards for its engines: both are twin-turbo inline sixes, one powered by gasoline and the other by ultra-low sulfur diesel. Direct injection, low-mass twin turbochargers, and high-strength aluminum construction enable both powerplants to offer unparalleled levels of power, efficiency, and refinement.
The twin-turbo gasoline unit finds its way into eleven BMW models for the 2009 U.S. market including the 135i, 335 sedan and coupe models, the 535i sedan, and the X6 xDrive 35i SAV. The twin sequential turbocharged 3.0-liter diesel six is new to the U.S. for 2009, and will be featured in the 335d sedan and the somewhat awkwardly-named X5 Xdrive35d. Performance figures for these diesels are far from pokey, thrusting the 3-series sedan from rest to 60 mph in 6.0 seconds flat, the X5 in 6.9. And even with 425 lb-ft on tap, the 335d manages 36 mpg and the X5 Xdrive35d 26 mpg, both highway figures.
In a world where packaging efficiency has led most automakers, even Mercedes, to abandon the lengthy inline-six in favor of a more compact V-6 layout, BMW has stuck resolutely to its legendary inline six. One of the smoothest engine configurations possible due to evenly-spaced power pulses at the crankshaft, BMW inline sixes love to rev and do not require counter-rotating balance shafts for silky smooth operation.
2009 BMW 335dEnlarge Photo


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Aisha: The Beloved of Mohammed
1985 · London
by Abbott, Nabia
London: Al Saqi Books, 1985. Paperback. Near Fine. Paperback, 1985, octavo, 230pp., illustrated with one b&w map at rear. Book near fine with hint of shelfwear and soil to wrap, binding tight, text clean and unmarked. No DJ. (Inventory #: B35831)


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Due to restrictions by my previous employer I was force to stop my blogging. As per their policies we should NOT do lot of things, which includes Blogging too. It was literally irritating to me. But I was enjoyed Life @ there. It was brilliant. I have done lots of things. But I forget my favorite hobby. I was force to shutdown my blog http://subin.info.
Now I left them and I started missing my hobby. Ultimately my blog too. So I decided to come with a new me domain, which I feel more personal or at least more close me 🙂
Now I am planning to come out this BLOG as a platform to express my thoughts, my ideas and to share my knowledge, thoughts and thirst.
I am welcoming you all to this blog and expressing my thanks to all of you for the support.
Disclaimer:- All the information/content posted here is NO WHERE related to my current employer or any of my previous employers. This is purely my asset and I am posting them with personal experience. This is applicable to all the blogs/pages/comments and all the upcoming blogs in the subin.me


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In this webinar we discuss how brands should pick their content creator partners in order to become effective members of digital communities.
The rules have changed. Content creators are everywhere, and you need to decide which ones you, as a brand, want to work with. How should you work with them in a way that respects the creator but also helps you achieve your objectives?
Brands need to add value to the digital communities they're part of, and be respected by those communities. This is where the Digital Social Contract comes into play, a brand new Ogilvy Red Paper that discusses how brands should work within the confines of the social rules of our new world. On this webinar, we unveil proprietary research and analysis and share key takeaways from the study. We answer the following questions:
- How should brand decide which content creators to partner with?
- What are the 6 articles of the Digital Social Contract?
- What is the superfan phenomenon?
- What is the Ogilvy Creator Community 30 list?
- What 4 actions does a brand need to take in order to be a respected and effective member of digital communities?
View a recording of the session and read or download The Digital Social Contract paper below:


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20 / Female / Straight / Single
Wonderland – US
Hai! My name is Sin. I suck at talking about myself, so this won't be too long. Well, one thing is for certain, I'm in love with anime. Anime is life. Heh, yeah.. I'm a pretty laidback person. I have an open mind, & I'm not judgemental. Although, I will not tolerate perverted pigs. So watch yourself. Anyway, that's enough about me. If you wanna know more, you'll have to talk to me.😁
Current Status View All Statuses
I need new friends. Actual friends. Ones that won't just vanish one day.
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justjames asked
why are you such a wonderful person0 Comments
I honestly don't know... I personally think I'm not that great, just, non-existent. So yeah.. but thanks love.


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Signs Your Ex Is Over You
Signs Your Ex Is Over You
Learn To Read The Signs The Right Way – Not Everything Is As It Seems
Whenever the break up happens people are often curious to know if their exes are still interested in them or if they have moved on. When you know how to read the signs you will have a better grasp of the reality of your own situation.
There is nothing worse than trying to get your ex back when they have long gotten over you and have moved on, it is humiliating. That is why it is a good idea to arm yourself with as much knowledge as possible so that you can read the signs yourself and prevent this from happening.
We are going to discuss what you should be looking out for and why everything is not always as it seems. You have to delve a little deeper if you want to know the truth about how your ex really feels. It is important that you don't go rushing in full steam ahead before reading these signs, you could end up making a fool or yourself and pushing your ex even further away. So let's get started.
Sign 1 – They Refuse To Talk To You
When your ex is still interested in getting back together they will want to leave the lines of communication open. However, if they are adamant that they do not want you back in their lives it will often come across that they do not want to talk to you and are ignoring you. This is not always a bad sign though. It depends upon when you broke up. You see, when your ex is still hurting from the break up they will want to retaliate in any way that they can and hurt you back, just to get a reaction out of you. The best way that they can do this is by refusing to talk to you. It doesn't necessarily mean that they do not like you anymore or that all of their feelings have dissipated. You have to judge your own personal situation to know exactly how to read the signs.
Your ex could be angry that you cheated on them for example and want to teach you a lesson. They also may not really know what to say to you. Break ups are awkward and having to adjust to a new platonic relationship with you can be confusing. They might just need some time to make sense of it before they approach you again. Look at how long ago you broke up to guage whether or not your ex is over you or not. If you broke up a short time ago then your ex refusing to talk to you is not necessarily a bad thing. However, if it has been some time since the break up and your ex still doesn't talk to you, it is a sure sign that they are over you or at the very least, do not want you in their lives anymore.
Sign 2 – Your Ex's Body Language
Look at your ex's body language when you are with them. Even if they do not say anything to you, there are still ways for you to figure out if they are over you or not. A positive sign is when your ex leans towards you an has 'open body language'. Also look out for your ex staring at you or trying to catch your attention. These are sure signs that they still are interested in you. Bad signs are when your ex crosses their arms in your presence. This is closed body language and means that your ex is kind of hostile towards you or is trying to protect themselves.
Read Her Body Language
When girls like a guy they will be flirtatious and giggle. This may be subtle, but look out for it if you are in her company again. Likewise, when a girl flutters her eyelids, plays with her hair, or pouts, they are trying to be more attractive to you. Other signs to look out for is her touching you or sitting close beside you. Conversely, if she doesn't seem bothered about how she looks in front of you, this normally means that she isn't trying to impress you. When she avoids being anywhere near you or sits as far away from you as possible, it usually means that she does not want to engage with you. Find out how to get my girlfriend back.
Read His Body Language
Men will often stand up tall to portray the more masculine side of their personality if they are interested in you. Watch out for him being protective towards you like he was when you were together. For example, does he pull seats out for you or put a protective arm around your shoulder? If so, it shows that he still cares for you. He may also be trying to show off in front of you to get your attention. This is a very masculine trait, rather like the mating game. It is him trying to appeal to you and display his credentials. Watch out for this. Conversely, if your ex boyfriend pays you no attention whatsoever, is constantly looking at other girls or seems distracted, it is a clear sign that he is over you. Find out how to get my boyfriend back.
Sign 3 – They're Going Out With Someone Else
This again depends on how recent your break up was. If it has been a long time since you broke up and your ex is in a new relationship, the chances are that they have moved on and have no residual feelings left for you.
On the other hand, if you have both just broken up and you find that your ex has suddenly jumped into a new relationship, there is a huge chance that this is a rebound. Your ex will be consciously trying to get over you and this will be a desperate attempt on their part to make it happen. They could also be wanting to teach you a lesson, wanting to hurt you as much as you hurt them.
You cannot just take things at face value here, you might be completely heartbroken when you find out that your ex has started to date someone, but read between the lines, it doesn't necessarily mean that they are over you, they could be trying to provoke a reaction in you and this is a very effective way of doing so.
You can change how your ex feels about you and make them realise that they are with the wrong person. Surprisingly it is rather straightforward to do, you just have to plug into some human psychology to know exactly what buttons to push in your ex. Find out more about this here.
Sign 4 – No Contact With You For Months
Again, look at how long ago the break up was. Did it happen a few days ago? Don't take no contact as a sign that your ex is already over you if this is the case. Your ex will be trying to work out how they feel and deal with the break up on their own terms. The best way for them to do this is to cut contact with you. They will also not know what to say to you and will be frightened of sparking a negative reaction in you.
Another thing that your ex may be trying to do with no contact is to provoke you in some way or prove a point. If you were the one that broke up with them then they will want to cause you pain too. Their pride will be at stake here so they do not want to appear desperate and contact you just to be rejected again. If they were the one that broke up with you then they will just want their space, so give it to them initially anyway.
The longer the no contact phase goes on, the more you should start to worry. If there has been no sort of contact from your ex for months it is clearly a bad sign. They will have wanted to see how you are or at least craved any kind of communication with you if they still had feelings. Your ex could be incredibly stubborn and determined, either that or they have just moved on and do not feel the need to stay in touch with you.
Look out for signs that your ex is enjoying themselves and getting on with their lives. When they are not looking back over their shoulders at you and reminiscing at the good times, it means that they have put it all behind them and do not want to go there again. Don't let this dishearten you though, you have to keep in mind that relationships are only over when both partners have already given up.
How To Turn This Around And Make Your Ex Interested Again
There are ways that you can reverse this process though and make your ex sit up and take notice of you again. One way that you can do this is by taking a leaf out of their books. When you start to get back out there and live your life again, your ex will surely notice it and maybe feel pangs of jealousy or regret. This is also a highly attractive trait and will subconsciously make your ex warm towards you again.
When you dwell on your ex and the break up you will not be taking a positive step towards your own future and happiness. You can't control what your ex thinks and feels about you, but there are things that you can do to encourage them to think positively about you again and start seeing you as a potential partner. The key here is to identify what psychological buttons to push in your ex to make them want you back. When you understand something about male and female psychology, you will have a very good chance of making your ex want you and chase you again. Even when your ex is showing you all the above signs that they are over you, it is not necessarily too late to do something about it. The guide below will go into more detail about what exactly these specific techniques are.
The Ex Back Guide
Learn how to make your ex crave you like they once did, even if they are already going out with someone new , if it has been months since the break up and even if they are refusing to talk to you. There are proven psychological techniques that you can implement today to make your ex regret the break up and start seeing you as desirable and attractive again.
It will go into depth about becoming the person that your ex first loved again with the audio and pdf system. Tap into their mind and learn why they are acting the way they are towards you. These techniques work and have been very successful in getting back thousands of exes all over the world.


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September 15, 2010
German footwear giant Puma just dropped these Hussein Chalayan high tops and it is looking really nice and clean. The sneaker comes with two velcro straps in an all black premium leather version, featuring the Puma logo embossed on the tongue, patent leather ankle padding and an invisible Puma stripe logo on the side-panels. Hit the jump to view more images of the Puma Hussein Chalayan High Top now.


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APHA, AQHA, breeding showing, lessons, colt starting, Advanced training.
Rehabilitation and lay-ups offered. Specializing in race and show horse injuries.
Offer Farrier Services, Boarding and training. Also have hay for sale.
Multi-discipline Horses. We train our horses to do many events. We show Dressage, Eventing, Jumping, Pleasure, Reining, Trail, Driving and Gaming…
Beautiful 10 stall Barn with H/C wash rack, tack room and 2, 10 ft concrete aisles. Wooded 16 acres includes 50 ft round pin and 100x200 ring. Room…
Selling quality horses and ponies in the Aiken area. Riding lessons also available.
Therapeutic Small Family Farm Educational Programs for Children of all ages and abilities.
Carlsbad, NM


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Manilla & Cartridge Pads
Manilla paper pad is creamy yellow, light weight paper for all dry media. The creamy colour makes this paper great for conte and or pastel as well as graphite.
Cartridge paper pad is white drawing paper with a slight tooth. It is an affordable choice for students, schools and artists. Great for charcoal, graphite stick sketches, markers, and more.
These pads are ideal for gestures in figure drawing or for planning out a composition in your painting


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Negotiations aimed at averting a Chicago teachers strike continued into the early hours Sunday, as union leaders reported slight progress but maintained that if no settlement with the school board were reached overnight, a walkout would be inevitable.
``We`re moving slowly toward making some progress,`` said teachers union President Jacqueline Vaughn.
Salary remained the sticking point in the talks. The union has been pressing for a two-year contract, but Vaughn said late Saturday that the negotiations then were focused on a one-year contract.


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Serge Reding
Balance Number 1
Serge Reding is a male celebrity.
He was born on Tuesday December 23rd 1941, in Auderghem, Belgium,.
Serge Reding can very well draw strength from himself, but he has to be more willing to share his troubles with friends and family.
Serge can be a loner in the face of problems. This can isolate him during troubled times. Once Reding is open to the advice of others, it will widen his perspective on the problem and give him new information on which to base his approach.
Strength, creativity, and courage are the arms with which Serge Reding will win the war.
You and Serge
About Serge's Balance number
Maturity and self-development help us to learn new and more effective methods of handling our world and the problems we confront, and Serge Reding's Balance number provides him with the guidance on how best to deal with difficult or threatening situations.
Read more about our numerological interpretation of Serge Reding's balance